## Fri Jan 3 23:52:34 2025 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA757625/SRR15614349/SRR15614349_p_cluster_rep_seq.fasta --output PRJNA757625_SRR15614349 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k59_983077_15 1532557.JL37_15595 5.85e-122 368.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,3T1IK@506|Alcaligenaceae 28216|Betaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_983077_16 1049564.TevJSym_ar00070 3.45e-153 436.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1J4MN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO2768,iUTI89_1310.UTI89_C2601 Carboxyl_trans k59_133548_2 720554.Clocl_0046 4.62e-59 207.0 COG0457@1|root,COG0457@2|Bacteria,1UY9T@1239|Firmicutes,24BEA@186801|Clostridia,3WHTM@541000|Ruminococcaceae 186801|Clostridia S Oxygen tolerance - - - - - - - - - - - - BatD k59_950704_1 929558.SMGD1_0321 1.96e-75 253.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2YMRQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_819778_1 566466.NOR53_631 1.08e-80 256.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins - - 1.1.99.3 ko:K06151 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_983084_1 387093.SUN_0031 2.85e-10 60.8 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE k59_329730_1 864069.MicloDRAFT_00047570 2.6e-44 150.0 COG0782@1|root,COG0782@2|Bacteria,1RHU5@1224|Proteobacteria,2U95I@28211|Alphaproteobacteria,1JTCS@119045|Methylobacteriaceae 28211|Alphaproteobacteria K PFAM Transcription elongation factor, GreA GreB greB - - - - - - - - - - - GreA_GreB k59_721830_1 1449065.JMLL01000010_gene988 7.82e-11 65.5 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,43H8C@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_721830_2 1294273.roselon_01048 2.82e-05 46.2 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_983090_1 1358423.N180_10995 4.67e-07 57.0 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1IPF5@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_852704_1 990073.ATHU01000003_gene1825 1.56e-117 353.0 COG2223@1|root,COG2223@2|Bacteria,1QVWW@1224|Proteobacteria,43CKR@68525|delta/epsilon subdivisions,2YN1B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_166259_1 1123400.KB904816_gene1606 4.64e-41 147.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,46067@72273|Thiotrichales 72273|Thiotrichales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_166259_2 551789.ATVJ01000002_gene2866 1.43e-32 120.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria,43WQM@69657|Hyphomonadaceae 28211|Alphaproteobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner lolD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0031224,GO:0032991,GO:0033036,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_34923_1 572544.Ilyop_1840 2.7e-60 187.0 COG1939@1|root,COG1939@2|Bacteria,37AAB@32066|Fusobacteria 32066|Fusobacteria J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) mrnC - - ko:K11145 - - - - ko00000,ko01000,ko03009 - - - Ribonuclease_3 k59_34923_2 572544.Ilyop_1841 8.84e-44 154.0 COG0215@1|root,COG0215@2|Bacteria,378N1@32066|Fusobacteria 32066|Fusobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_460503_1 1379270.AUXF01000005_gene406 4.88e-29 117.0 COG1232@1|root,COG1232@2|Bacteria,1ZUZT@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_100737_1 118005.AWNK01000003_gene2209 6.21e-39 146.0 COG0513@1|root,COG0513@2|Bacteria 2|Bacteria L helicase activity rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_918205_1 1249627.D779_2839 3.91e-86 278.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1SYHR@1236|Gammaproteobacteria,1WZZ5@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_819800_2 1234364.AMSF01000085_gene2863 4.1e-35 127.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1X3PE@135614|Xanthomonadales 135614|Xanthomonadales F Belongs to the SAICAR synthetase family purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_198663_1 1387312.BAUS01000007_gene2230 1.9e-35 137.0 COG4943@1|root,COG4943@2|Bacteria,1MVTH@1224|Proteobacteria,2VNSA@28216|Betaproteobacteria 28216|Betaproteobacteria T signal transduction protein containing sensor and EAL - - - - - - - - - - - - CSS-motif,EAL k59_558553_1 56780.SYN_01264 1.22e-51 167.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MQJI@213462|Syntrophobacterales 28221|Deltaproteobacteria Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_884930_1 1165841.SULAR_02653 1.18e-65 218.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42NK1@68525|delta/epsilon subdivisions,2YMHN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the AAA ATPase family ftsH1 - - - - - - - - - - - AAA,Peptidase_M41 k59_819802_1 720555.BATR1942_06410 5.02e-48 176.0 COG1020@1|root,COG1028@1|root,COG3321@1|root,COG4221@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HTBC@91061|Bacilli,1ZS7J@1386|Bacillus 91061|Bacilli IQ polyketide synthase - - - ko:K13611,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_623692_1 563040.Saut_0525 1.91e-54 191.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2YMB3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB1 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_427383_1 525904.Tter_0051 3.09e-113 349.0 COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria 2|Bacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_950745_1 931626.Awo_c10950 8.78e-73 234.0 COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,25VYV@186806|Eubacteriaceae 186801|Clostridia S Psort location - - - - - - - - - - - - AATase k59_787139_1 1168034.FH5T_12310 2.22e-43 156.0 COG3968@1|root,COG3968@2|Bacteria,4NG2B@976|Bacteroidetes,2FMC9@200643|Bacteroidia 976|Bacteroidetes S Glutamate--ammonia ligase, catalytic domain protein glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C k59_394949_1 1380394.JADL01000010_gene4344 4.01e-67 214.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria,2JPM9@204441|Rhodospirillales 204441|Rhodospirillales EP N-terminal TM domain of oligopeptide transport permease C - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_590986_1 3649.evm.model.supercontig_514.3 1.17e-55 186.0 COG0126@1|root,KOG1367@2759|Eukaryota,37R6T@33090|Viridiplantae,3GA5G@35493|Streptophyta,3HW57@3699|Brassicales 35493|Streptophyta G Phosphoglycerate kinase - GO:0002237,GO:0003674,GO:0003824,GO:0004618,GO:0004672,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005829,GO:0005886,GO:0005911,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006464,GO:0006468,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009314,GO:0009408,GO:0009416,GO:0009506,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009743,GO:0009746,GO:0009749,GO:0009987,GO:0010033,GO:0016020,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0030054,GO:0031090,GO:0032787,GO:0034284,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036211,GO:0042221,GO:0042866,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048046,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0055044,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0098588,GO:0098805,GO:0140096,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901700 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_819814_1 1041139.KB902668_gene2894 5.85e-127 373.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TU6U@28211|Alphaproteobacteria,4B7QK@82115|Rhizobiaceae 28211|Alphaproteobacteria E glutamine synthetase glnA2 - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_67858_1 519989.ECTPHS_14156 9.7e-69 211.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_133596_1 1049564.TevJSym_aj00730 2.02e-09 60.8 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1J4N6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_9,Response_reg k59_133596_2 1255043.TVNIR_3194 6.07e-45 164.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_263894_1 1304284.L21TH_0369 9.5e-178 508.0 COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia,36F5C@31979|Clostridiaceae 186801|Clostridia S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_525816_1 1055815.AYYA01000071_gene2243 2.59e-19 87.4 COG4929@1|root,COG4929@2|Bacteria,1MZW2@1224|Proteobacteria,1S96E@1236|Gammaproteobacteria,3NK4X@468|Moraxellaceae 1236|Gammaproteobacteria S GDYXXLXY protein - - - - - - - - - - - - DUF2157,DUF4401,GDYXXLXY k59_460539_1 1168034.FH5T_07515 3.27e-91 282.0 COG3595@1|root,COG3595@2|Bacteria,4NJCC@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - DUF4097 k59_34958_1 406818.XBJ1_1968 2.97e-75 252.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_656783_1 1165841.SULAR_09214 4.07e-56 179.0 COG1585@1|root,COG1585@2|Bacteria,1QAJG@1224|Proteobacteria,43AB2@68525|delta/epsilon subdivisions,2YQRB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria OU Membrane protein implicated in regulation of membrane protease activity - - - ko:K07340 - - - - ko00000 - - - NfeD k59_656783_2 1165841.SULAR_09219 7.33e-57 184.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2YMHX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Membrane protease subunits - - - - - - - - - - - - Band_7 k59_590996_1 1408164.MOLA814_02467 1.29e-21 101.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria 28216|Betaproteobacteria M transglycosylase slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_558585_1 187272.Mlg_0956 3.38e-76 253.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales 135613|Chromatiales F PFAM glycosyl transferase family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_950764_1 1121895.Q765_08825 1.89e-06 52.0 COG1404@1|root,COG1572@1|root,COG3291@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,COG3291@2|Bacteria,4NDZC@976|Bacteroidetes,1I0G4@117743|Flavobacteriia,2NT7Y@237|Flavobacterium 976|Bacteroidetes M Pkd domain containing protein - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - CHU_C,He_PIG,fn3 k59_950764_2 794903.OPIT5_30725 1.75e-09 58.2 2DN84@1|root,32W19@2|Bacteria,46W13@74201|Verrucomicrobia,3K9NJ@414999|Opitutae 414999|Opitutae - - - - - - - - - - - - - - - k59_231598_1 1089551.KE386572_gene3544 5.19e-20 89.7 COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,2TU5N@28211|Alphaproteobacteria,4BQ0A@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_231598_3 935840.JAEQ01000001_gene3117 5.45e-14 75.5 28Q4X@1|root,2ZCN0@2|Bacteria,1RA2A@1224|Proteobacteria,2U5RP@28211|Alphaproteobacteria,43JRF@69277|Phyllobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_296805_1 665571.STHERM_c17680 5.89e-64 210.0 COG3693@1|root,COG4733@1|root,COG3693@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity xynB3 - 3.2.1.78,3.2.1.8 ko:K01181,ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - Alginate_lyase,CBM_3,CBM_6,Cytochrom_NNT,Dockerin_1,Glyco_hydro_10,Laminin_G_3,Paired_CXXCH_1,fn3 k59_525836_1 749222.Nitsa_0406 7.19e-56 192.0 COG2195@1|root,COG2195@2|Bacteria,1MUWK@1224|Proteobacteria,42PS0@68525|delta/epsilon subdivisions,2YMQC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Dipeptidase pepD - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M20 k59_787166_1 702450.CUW_1104 4.68e-19 90.1 2AYHW@1|root,31QMC@2|Bacteria,1VJHN@1239|Firmicutes,3VRZJ@526524|Erysipelotrichia 526524|Erysipelotrichia S TraX protein - - - - - - - - - - - - TraX k59_721890_1 530564.Psta_1856 1.69e-88 283.0 COG1166@1|root,COG1166@2|Bacteria,2IX6P@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_296812_2 987059.RBXJA2T_07573 9.26e-53 181.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VMJK@28216|Betaproteobacteria,1KNFI@119065|unclassified Burkholderiales 28216|Betaproteobacteria I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_918268_1 203124.Tery_4209 8.69e-87 281.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1G0GP@1117|Cyanobacteria,1H9GG@1150|Oscillatoriales 1117|Cyanobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_525842_1 187272.Mlg_2533 1.2e-51 182.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales 135613|Chromatiales E PFAM peptidase M3A and M3B, thimet oligopeptidase F - - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_134408_1 7213.XP_004528046.1 1.49e-77 256.0 COG0488@1|root,KOG0927@2759|Eukaryota,3AHX4@33154|Opisthokonta,3BYSV@33208|Metazoa,3DFWV@33213|Bilateria,42B08@6656|Arthropoda,3SQIT@50557|Insecta,459C0@7147|Diptera 33208|Metazoa S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_134408_2 1415778.JQMM01000001_gene1460 2.76e-10 57.4 COG2900@1|root,COG2900@2|Bacteria 2|Bacteria S Belongs to the SlyX family slyX - - ko:K03745 - - - - ko00000 - - - SlyX k59_559447_1 561229.Dd1591_0606 7.29e-64 212.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,2JDYK@204037|Dickeya 1236|Gammaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008766,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0047480,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iB21_1397.B21_00086,iEC042_1314.EC042_0087,iEC55989_1330.EC55989_0082,iECBD_1354.ECBD_3531,iECB_1328.ECB_00087,iECD_1391.ECD_00087,iECIAI1_1343.ECIAI1_0085,iECO103_1326.ECO103_0088,iECO111_1330.ECO111_0089,iECO26_1355.ECO26_0089,iECSE_1348.ECSE_0088,iECW_1372.ECW_m0085,iEKO11_1354.EKO11_3828,iEcE24377_1341.EcE24377A_0088,iEcHS_1320.EcHS_A0092,iEcolC_1368.EcolC_3571,iSBO_1134.SBO_0074,iSSON_1240.SSON_0094,iSbBS512_1146.SbBS512_E0079,iUMNK88_1353.UMNK88_86,iWFL_1372.ECW_m0085,iYL1228.KPN_00090 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_820566_2 543728.Vapar_3546 8.25e-09 53.1 2AGAH@1|root,316G1@2|Bacteria,1N2FZ@1224|Proteobacteria,2WDAY@28216|Betaproteobacteria,4AIKB@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_657645_1 439235.Dalk_3613 6.45e-92 278.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MMPC@213118|Desulfobacterales 28221|Deltaproteobacteria NU PFAM Type II IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_754921_2 1236514.BAKL01000006_gene761 1.58e-13 68.6 COG4409@1|root,COG4409@2|Bacteria,4PKIP@976|Bacteroidetes,2G19F@200643|Bacteroidia,4AVHB@815|Bacteroidaceae 976|Bacteroidetes G BNR repeat-like domain - - - - - - - - - - - - BNR_2 k59_657647_1 1415780.JPOG01000001_gene525 7.49e-16 73.9 2CJPW@1|root,32SAH@2|Bacteria,1NAJ3@1224|Proteobacteria,1SAPE@1236|Gammaproteobacteria,1XAMU@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_657647_2 756272.Plabr_0485 1.83e-07 51.6 COG1932@1|root,COG1932@2|Bacteria,2IYR7@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_35712_1 1226994.AMZB01000122_gene2768 9.74e-95 290.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1YDY0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - iEC55989_1330.EC55989_0819,iECO111_1330.ECO111_0837,iECO26_1355.ECO26_0902,iSDY_1059.SDY_0830 Aminotran_1_2 k59_919113_1 1049564.TevJSym_aj00350 4.71e-51 177.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1J4PM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_722513_1 398720.MED217_06676 1.35e-156 449.0 COG1064@1|root,COG1064@2|Bacteria,4NFGP@976|Bacteroidetes,1HXI9@117743|Flavobacteriia,2XHZS@283735|Leeuwenhoekiella 976|Bacteroidetes S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953,ko:K13979 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1016674_1 1121094.KB894650_gene2398 6.66e-86 269.0 COG3119@1|root,COG3119@2|Bacteria,4NEFN@976|Bacteroidetes,2FQ6F@200643|Bacteroidia,4APGW@815|Bacteroidaceae 976|Bacteroidetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - DUF4994,Sulfatase k59_167236_1 929556.Solca_3513 2.82e-38 135.0 COG1595@1|root,COG1595@2|Bacteria,4NMAK@976|Bacteroidetes,1ISGD@117747|Sphingobacteriia 976|Bacteroidetes K PFAM RNA polymerase sigma factor 70, region 4 type 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_330585_1 1128398.Curi_c25460 4.32e-11 63.5 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,24CES@186801|Clostridia,26900@186813|unclassified Clostridiales 186801|Clostridia HP ATPases associated with a variety of cellular activities - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_559475_2 366394.Smed_5626 5.68e-61 196.0 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,4BAX2@82115|Rhizobiaceae 28211|Alphaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl k59_1016676_1 1249480.B649_02835 2.16e-168 487.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42M1K@68525|delta/epsilon subdivisions,2YMKR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the peptidase M24B family pepQ - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C k59_232301_1 1249480.B649_03350 5.98e-74 227.0 COG0454@1|root,COG0456@2|Bacteria,1NPCX@1224|Proteobacteria,42ZWJ@68525|delta/epsilon subdivisions,2YRWX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_7 k59_232301_2 760154.Sulba_0437 1.09e-41 141.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2YPJX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_657670_1 1265313.HRUBRA_02746 1.65e-98 296.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria 1236|Gammaproteobacteria G glucose sorbosone yliI - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH k59_2368_2 1165841.SULAR_00050 4.79e-50 160.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,42SEH@68525|delta/epsilon subdivisions,2YPE2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FG Hit family - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_493905_1 1198452.Jab_2c20530 2.18e-63 218.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,472ZI@75682|Oxalobacteraceae 28216|Betaproteobacteria U Efflux pump acrB - - ko:K03296,ko:K18138,ko:K18322 ko01501,ko01503,ko02020,map01501,map01503,map02020 M00645,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.41 - - ACR_tran k59_264596_1 986075.CathTA2_1529 8.58e-43 154.0 COG0683@1|root,COG0683@2|Bacteria,1V4XA@1239|Firmicutes,4HYGJ@91061|Bacilli 91061|Bacilli E Receptor family ligand binding region - - - - - - - - - - - - Peripla_BP_6 k59_758756_3 572544.Ilyop_2826 1.86e-10 57.4 COG3462@1|root,COG3462@2|Bacteria 2|Bacteria S membrane protein (DUF2078) - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_335009_1 1278073.MYSTI_07741 9.83e-16 82.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria 1224|Proteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX,MacB_PCD k59_954885_2 1049564.TevJSym_aq00040 8.52e-27 109.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1J4NI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction histidine kinase, nitrogen specific glnL GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_790941_1 748449.Halha_2503 1.04e-05 47.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,24B6F@186801|Clostridia,3WBC8@53433|Halanaerobiales 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_790941_2 1123274.KB899419_gene1907 6.28e-41 154.0 COG1609@1|root,COG1609@2|Bacteria,2J6Q3@203691|Spirochaetes 203691|Spirochaetes K PFAM Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_758762_1 199310.c3203 2.05e-09 61.2 2E3KU@1|root,32YJ4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_758762_2 1165841.SULAR_01988 1.05e-11 63.9 COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,42QNP@68525|delta/epsilon subdivisions,2YR5C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of dihydroorotate to orotate - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_498169_1 1158165.KB898871_gene2178 4.27e-86 261.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1WVZH@135613|Chromatiales 135613|Chromatiales F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_4768_1 525898.Sdel_0460 9.25e-212 592.0 COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,42P1X@68525|delta/epsilon subdivisions,2YR03@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K PFAM Filamentation induced by cAMP - - - - - - - - - - - - Fic,HTH_24 k59_138857_1 395493.BegalDRAFT_2147 2.89e-151 465.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1MVG5@1224|Proteobacteria,1SZ1A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L TaqI-like C-terminal specificity domain - - - - - - - - - - - - Eco57I,TaqI_C k59_335011_1 395493.BegalDRAFT_1422 5.07e-68 231.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,45ZPA@72273|Thiotrichales 72273|Thiotrichales F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_367290_1 391623.TERMP_01467 5.89e-13 68.6 COG0778@1|root,arCOG00288@2157|Archaea,2XXW2@28890|Euryarchaeota,242IJ@183968|Thermococci 183968|Thermococci C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_367290_2 404380.Gbem_1758 1.81e-11 64.3 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,42URP@68525|delta/epsilon subdivisions,2WQFZ@28221|Deltaproteobacteria,43UTN@69541|Desulfuromonadales 28221|Deltaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_203564_1 219305.MCAG_05171 3.35e-09 60.1 COG4275@1|root,COG4275@2|Bacteria,2IK0B@201174|Actinobacteria,4DIR5@85008|Micromonosporales 201174|Actinobacteria S Chromate resistance exported protein - - - - - - - - - - - - Chrome_Resist k59_171203_1 933262.AXAM01000046_gene132 6.52e-38 143.0 COG1404@1|root,COG1404@2|Bacteria,1NR78@1224|Proteobacteria 1224|Proteobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - - k59_367303_1 1168034.FH5T_14935 5.72e-97 304.0 COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,2FWMX@200643|Bacteroidia 976|Bacteroidetes E Amino acid permease - - - - - - - - - - - - AA_permease k59_824644_1 1187851.A33M_1808 1.64e-34 124.0 COG3692@1|root,COG3692@2|Bacteria,1N3PG@1224|Proteobacteria,2VG74@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PemK-like, MazF-like toxin of type II toxin-antitoxin system - - - - - - - - - - - - PemK_toxin k59_824644_2 1033802.SSPSH_001661 4.31e-18 94.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_465554_1 572544.Ilyop_0357 2.42e-62 211.0 COG0249@1|root,COG0249@2|Bacteria,378K4@32066|Fusobacteria 32066|Fusobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_465554_2 572544.Ilyop_0356 1.48e-159 454.0 COG0042@1|root,COG0042@2|Bacteria,3796Y@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - - - - - - - - - - Dus k59_465554_3 1238184.CM001792_gene1771 8.46e-13 70.5 COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,4HH8Z@91061|Bacilli,23NG3@182709|Oceanobacillus 91061|Bacilli J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_432332_1 264198.Reut_A3256 5.82e-11 61.2 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,1K982@119060|Burkholderiaceae 28216|Betaproteobacteria C cytochrome C - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_596453_1 472759.Nhal_0533 8.22e-16 77.4 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales 135613|Chromatiales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_596453_2 1235457.C404_08075 5.48e-44 150.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,1K0K6@119060|Burkholderiaceae 28216|Betaproteobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_923893_1 1117647.M5M_12075 2.12e-05 48.9 2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria,1S3S1@1236|Gammaproteobacteria,1JAD6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_923893_2 1278307.KB907040_gene1962 1.05e-32 116.0 COG1550@1|root,COG1550@2|Bacteria,1NGDU@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF503) - - - ko:K09764 - - - - ko00000 - - - DUF503 k59_236899_1 1380391.JIAS01000015_gene154 8.64e-54 182.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,2JQNS@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_139588_2 1165841.SULAR_05593 8.85e-43 149.0 COG2177@1|root,COG2177@2|Bacteria,1R85B@1224|Proteobacteria,42PX3@68525|delta/epsilon subdivisions,2YQ4H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Cell division protein ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - k59_531729_1 291112.PAU_00306 1.61e-62 195.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases crp GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007584,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0030551,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0035438,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045013,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045990,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140110,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,cNMP_binding k59_5209_1 330214.NIDE3498 3.44e-59 205.0 COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria 2|Bacteria KT transcription factor binding fhlA GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009 ko02020,ko02025,ko05132,map02020,map02025,map05132 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,GAF_3,HTH_8,Sigma54_activat k59_236900_1 648757.Rvan_0234 1.14e-116 346.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,3N6EK@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_726866_1 439235.Dalk_1519 9.02e-128 378.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,42MMI@68525|delta/epsilon subdivisions,2WJZI@28221|Deltaproteobacteria,2MJBI@213118|Desulfobacterales 28221|Deltaproteobacteria C molybdenum-iron protein alpha chain nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_368030_1 2340.JV46_14610 2.02e-115 344.0 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_988874_1 1300345.LF41_1087 4.42e-22 98.2 COG5505@1|root,COG5505@2|Bacteria,1MW87@1224|Proteobacteria,1RQPZ@1236|Gammaproteobacteria,1X4GS@135614|Xanthomonadales 135614|Xanthomonadales S membrane - - - - - - - - - - - - DUF819 k59_432348_1 997884.HMPREF1068_02505 2.08e-53 179.0 COG0566@1|root,COG0566@2|Bacteria,4NG1U@976|Bacteroidetes,2FNE2@200643|Bacteroidia,4AN33@815|Bacteroidaceae 976|Bacteroidetes J RNA methyltransferase, TrmH aviRb - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind k59_368035_1 926550.CLDAP_31170 7.11e-14 76.3 COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,2G7PG@200795|Chloroflexi 200795|Chloroflexi T ATP-binding region, ATPase domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,HisKA_7TM,PAS_4,PAS_8,Response_reg k59_629510_1 746697.Aeqsu_1224 6.33e-72 243.0 COG1196@1|root,COG1196@2|Bacteria,4NF7P@976|Bacteroidetes,1HYD4@117743|Flavobacteriia 976|Bacteroidetes D ATPase involved in DNA repair - - - - - - - - - - - - DUF4175 k59_988880_1 649638.Trad_0096 1.24e-67 219.0 COG1282@1|root,COG1282@2|Bacteria,1WICZ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_923907_1 929558.SMGD1_2652 5.57e-79 253.0 COG2025@1|root,COG2086@1|root,COG2025@2|Bacteria,COG2086@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2YQDA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Electron transfer flavoprotein FAD-binding domain - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_531740_1 497965.Cyan7822_0733 2.88e-43 151.0 29Z9K@1|root,30M7T@2|Bacteria,1GM3Q@1117|Cyanobacteria,3KJ43@43988|Cyanothece 1117|Cyanobacteria S Protein of unknown function (DUF3592) - - - - - - - - - - - - DUF3592 k59_73821_1 243233.MCA0195 5.23e-103 312.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1XE7S@135618|Methylococcales 135618|Methylococcales S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_498952_1 929558.SMGD1_2861 5.3e-150 445.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2YMN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA_synt_2f k59_498952_2 1537917.JU82_01275 5.08e-27 108.0 COG0665@1|root,COG0665@2|Bacteria,1Q0BQ@1224|Proteobacteria,42RXA@68525|delta/epsilon subdivisions,2YP66@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E COGs COG0665 Glycine D-amino acid oxidase (deaminating) - - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO k59_39638_1 1123373.ATXI01000019_gene736 5.43e-21 102.0 COG2199@1|root,COG2905@1|root,COG2905@2|Bacteria,COG3706@2|Bacteria,2GHH1@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T diguanylate cyclase - - - - - - - - - - - - CBS,GGDEF,PAS_9 k59_5219_1 1499680.CCFE01000021_gene2313 2.95e-85 275.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4HCEP@91061|Bacilli,1ZBU0@1386|Bacillus 91061|Bacilli C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_564234_1 572544.Ilyop_0737 0.0 878.0 COG0481@1|root,COG0481@2|Bacteria,37898@32066|Fusobacteria 32066|Fusobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_564234_3 861452.HMPREF9093_00361 1.07e-86 265.0 COG0157@1|root,COG0157@2|Bacteria,378A3@32066|Fusobacteria 32066|Fusobacteria H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767,ko:K03813 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_662482_1 1046714.AMRX01000007_gene1962 1.03e-14 73.9 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,1RSM7@1236|Gammaproteobacteria,4661S@72275|Alteromonadaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_662482_2 553220.CAMGR0001_2258 5.03e-40 139.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2YP63@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_791321_1 1168034.FH5T_20460 1.21e-182 527.0 COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,2FR3B@200643|Bacteroidia 976|Bacteroidetes O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Glyco_hydro_127,Glyco_hydro_76,Thioredox_DsbH k59_466172_1 572544.Ilyop_0361 2.47e-81 264.0 COG0013@1|root,COG0013@2|Bacteria,378SD@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_857798_1 1415756.JQMY01000001_gene2873 1.5e-41 148.0 COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2TQYX@28211|Alphaproteobacteria,2PCF0@252301|Oceanicola 28211|Alphaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family oxyS - - - - - - - - - - - HTH_1,LysR_substrate k59_955546_1 347834.RHE_CH01212 8.81e-54 183.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,4B8TA@82115|Rhizobiaceae 28211|Alphaproteobacteria G Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system - - - ko:K17215 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - ABC_tran k59_955546_2 347834.RHE_CH01211 5.14e-145 419.0 COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2U0D6@28211|Alphaproteobacteria,4BARC@82115|Rhizobiaceae 28211|Alphaproteobacteria G Ribose xylose arabinose galactoside ABC-type transport systems, permease components - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - ko:K02057,ko:K10440,ko:K17206,ko:K17214 ko02010,map02010 M00212,M00221,M00591,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.15,3.A.1.2.19 - - BPD_transp_2 k59_955546_3 1041138.KB890221_gene1039 9.81e-112 331.0 COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TW5I@28211|Alphaproteobacteria,4BIEQ@82115|Rhizobiaceae 28211|Alphaproteobacteria G Periplasmic binding protein-like domain MA20_14320 - - ko:K10439,ko:K17202,ko:K17205,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00590,M00591,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.15,3.A.1.2.16,3.A.1.2.19 - - Peripla_BP_4 k59_236939_2 1121929.KB898665_gene2730 9.9e-70 216.0 COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,4H9W0@91061|Bacilli,470I5@74385|Gracilibacillus 91061|Bacilli G Class II Aldolase and Adducin N-terminal domain araD GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_759543_1 1150621.SMUL_2783 1.13e-27 116.0 COG2215@1|root,COG3683@1|root,COG2215@2|Bacteria,COG3683@2|Bacteria,1MX4D@1224|Proteobacteria,42PHI@68525|delta/epsilon subdivisions,2YM9S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the NiCoT transporter (TC 2.A.52) family - - - - - - - - - - - - DUF1007,NicO k59_171944_1 1168034.FH5T_21805 4.67e-41 146.0 COG1726@1|root,COG1726@2|Bacteria,4NEDQ@976|Bacteroidetes,2FN6J@200643|Bacteroidia 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA - 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_171944_2 1168034.FH5T_21810 3.62e-129 376.0 COG4658@1|root,COG4658@2|Bacteria,4NFGW@976|Bacteroidetes,2FMD0@200643|Bacteroidia 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_1021450_1 882378.RBRH_02573 4.07e-86 285.0 COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2VP69@28216|Betaproteobacteria,1KC4Z@119060|Burkholderiaceae 28216|Betaproteobacteria Q PKS_DH rhiE - - ko:K15678 - - - - ko00000,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_629563_1 338963.Pcar_1849 4.48e-21 90.1 COG3216@1|root,COG3216@2|Bacteria,1QEG2@1224|Proteobacteria,42VUY@68525|delta/epsilon subdivisions,2WRD1@28221|Deltaproteobacteria,43SKM@69541|Desulfuromonadales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_335855_1 713586.KB900536_gene2727 1.4e-242 685.0 COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_368093_1 536227.CcarbDRAFT_3665 8.14e-31 123.0 COG2006@1|root,COG2006@2|Bacteria,1USN4@1239|Firmicutes,24ZG7@186801|Clostridia,36QA0@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 k59_694649_1 385682.AFSL01000089_gene926 2.68e-94 291.0 COG0702@1|root,COG0702@2|Bacteria,4PMK7@976|Bacteroidetes,2G0EJ@200643|Bacteroidia 976|Bacteroidetes GM SusD family - - - - - - - - - - - - SusD-like_3,SusD_RagB k59_694649_2 385682.AFSL01000089_gene927 4.45e-22 94.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FW53@200643|Bacteroidia,3XJUV@558415|Marinilabiliaceae 976|Bacteroidetes H TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_791340_1 207954.MED92_04649 5.19e-67 221.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1XHQ8@135619|Oceanospirillales 135619|Oceanospirillales CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases ubiH - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_335866_1 84531.JMTZ01000096_gene709 3.46e-62 208.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1X3M4@135614|Xanthomonadales 135614|Xanthomonadales F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004721,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009987,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_368101_1 318161.Sden_0415 1.38e-23 102.0 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria,2Q8I2@267890|Shewanellaceae 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family ybaL - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_825361_1 646529.Desaci_1877 1.61e-102 318.0 COG2185@1|root,COG2185@2|Bacteria,1UJHA@1239|Firmicutes,25F35@186801|Clostridia 186801|Clostridia I D-Lysine 5,6-aminomutase alpha subunit - - 5.4.3.5 ko:K17898 ko00472,map00472 - R02461 RC00719 ko00000,ko00001,ko01000 - - - B12-binding,Lys-AminoMut_A,OAM_dimer k59_204417_1 1165841.SULAR_07820 5.34e-47 154.0 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,42SKN@68525|delta/epsilon subdivisions 1224|Proteobacteria U PFAM Biopolymer transport protein ExbD TolR exbD - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_106917_1 1217718.ALOU01000052_gene3074 5.99e-56 191.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,1K3VG@119060|Burkholderiaceae 28216|Betaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG2 - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_531806_2 765914.ThisiDRAFT_2568 3.49e-40 139.0 COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,1S8TQ@1236|Gammaproteobacteria,1WYGU@135613|Chromatiales 135613|Chromatiales N flagellar protein FliS - - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k59_531806_3 754477.Q7C_2340 2.53e-12 69.7 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,1RS2S@1236|Gammaproteobacteria,460Z0@72273|Thiotrichales 72273|Thiotrichales N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end - - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_791342_1 399739.Pmen_0154 1.26e-93 300.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1YD1K@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_39694_1 385682.AFSL01000026_gene683 1.5e-97 296.0 COG0621@1|root,COG0621@2|Bacteria,4NZXZ@976|Bacteroidetes,2FX31@200643|Bacteroidia,3XJK6@558415|Marinilabiliaceae 976|Bacteroidetes J TRAM domain - - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_432418_1 1319815.HMPREF0202_01984 3.82e-226 663.0 COG0086@1|root,COG0086@2|Bacteria,378G7@32066|Fusobacteria 32066|Fusobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_432418_2 861452.HMPREF9093_00864 1.08e-37 137.0 COG1561@1|root,COG1561@2|Bacteria,379A0@32066|Fusobacteria 32066|Fusobacteria S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N k59_73899_2 706587.Desti_1944 7.24e-22 92.4 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,2MS9G@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_39695_1 1278307.KB906972_gene1203 2.63e-48 162.0 COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,1RQ60@1236|Gammaproteobacteria,2QIHC@267894|Psychromonadaceae 1236|Gammaproteobacteria L AP endonuclease family 2 nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_335884_1 493475.GARC_1218 1.2e-11 70.1 COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,1RRNT@1236|Gammaproteobacteria,464BN@72275|Alteromonadaceae 1236|Gammaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_212988_3 1151122.AQYD01000005_gene3279 1.29e-30 121.0 28HD0@1|root,2Z7PR@2|Bacteria,2IB30@201174|Actinobacteria,4FTA4@85023|Microbacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_275837_1 273068.TTE1214 4.45e-46 162.0 COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,247UX@186801|Clostridia,42FVS@68295|Thermoanaerobacterales 186801|Clostridia U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltT - - ko:K03309,ko:K11102,ko:K11103 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.23,2.A.23.1.1,2.A.23.1.2,2.A.23.1.3,2.A.23.1.6,2.A.23.1.7 - - SDF k59_114207_1 1380600.AUYN01000009_gene1444 9.44e-96 302.0 COG1554@1|root,COG1554@2|Bacteria,4NEWW@976|Bacteroidetes,1HXGZ@117743|Flavobacteriia 976|Bacteroidetes G Pfam Glycosyl hydrolase family 65, N-terminal domain - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2 k59_148035_1 926562.Oweho_2794 5.59e-16 82.4 COG2304@1|root,COG2911@1|root,COG3291@1|root,COG3420@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,4PPAE@976|Bacteroidetes,1IKH4@117743|Flavobacteriia,2PBVP@246874|Cryomorphaceae 2|Bacteria P alginic acid biosynthetic process - - 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - CHU_C,DUF642,Laminin_G_3,PKD k59_244623_2 1249627.D779_2665 3.08e-38 139.0 COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_637682_1 1121928.AUHE01000001_gene1679 2.85e-118 380.0 COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4GANM@85026|Gordoniaceae 201174|Actinobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_114211_1 1321774.HMPREF9108_02095 8.64e-115 342.0 COG1219@1|root,COG1219@2|Bacteria,378UC@32066|Fusobacteria 32066|Fusobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_114211_2 572544.Ilyop_0577 2.34e-38 142.0 COG0466@1|root,COG0466@2|Bacteria,3789S@32066|Fusobacteria 32066|Fusobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_114213_1 631362.Thi970DRAFT_01166 2.27e-84 261.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1WX2W@135613|Chromatiales 135613|Chromatiales J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_1028658_1 83406.HDN1F_14630 4.91e-38 138.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874 - ko:K13283 - - - - ko00000,ko02000 2.A.4.7.1 - - Cation_efflux,ZT_dimer k59_865375_1 1121440.AUMA01000010_gene389 6.97e-24 96.7 2E8Z0@1|root,3338K@2|Bacteria,1NA5U@1224|Proteobacteria,42VST@68525|delta/epsilon subdivisions,2WRG6@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF3783) - - - - - - - - - - - - DUF3783 k59_865375_2 525897.Dbac_0668 1.44e-17 79.7 COG4122@1|root,COG4122@2|Bacteria 2|Bacteria E O-methyltransferase activity - - - - - - - - - - - - Methyltransf_24,Methyltransf_3 k59_702526_1 472759.Nhal_2491 4.21e-104 330.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales 135613|Chromatiales G alpha amylase catalytic - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_1028661_1 1226994.AMZB01000138_gene5564 2.86e-42 142.0 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,1YGEY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P arsenate reductase arsC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_1028661_2 709032.Sulku_2374 4.87e-30 108.0 COG2841@1|root,COG2841@2|Bacteria,1NGDM@1224|Proteobacteria,42V3Q@68525|delta/epsilon subdivisions,2YQ8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF465) - - - ko:K09794 - - - - ko00000 - - - DUF465 k59_1028661_3 1537917.JU82_02440 1.52e-104 303.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,42MV8@68525|delta/epsilon subdivisions,2YMAE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_81222_1 642492.Clole_2855 1.95e-52 179.0 COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia 186801|Clostridia E Belongs to the alpha-IPM synthase homocitrate synthase family leuA3 - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_81222_2 526218.Sterm_0110 5.03e-96 291.0 COG0065@1|root,COG0065@2|Bacteria,379KW@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_767778_1 1249480.B649_10720 4.9e-56 176.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2YNWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_767778_2 1537917.JU82_01695 1.54e-104 304.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2YMJK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_767778_3 367737.Abu_1890 8.57e-10 55.8 COG0690@1|root,COG0690@2|Bacteria,1N8YN@1224|Proteobacteria,42VP0@68525|delta/epsilon subdivisions,2YQ7E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_767778_4 709032.Sulku_2277 3.45e-29 103.0 COG0267@1|root,COG0267@2|Bacteria,1NJ67@1224|Proteobacteria 1224|Proteobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_309421_1 326298.Suden_1707 5.17e-122 372.0 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,43BND@68525|delta/epsilon subdivisions,2YN2R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter transmembrane region - - - ko:K16299 ko02010,map02010 M00571 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110.10 - - ABC_membrane,ABC_tran k59_833190_1 553219.CAMSH0001_1682 7.43e-55 186.0 COG0614@1|root,COG0614@2|Bacteria,1NVK4@1224|Proteobacteria,42MBT@68525|delta/epsilon subdivisions,2YMTN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_407978_1 869213.JCM21142_93474 1.29e-39 144.0 COG0523@1|root,COG0523@2|Bacteria 2|Bacteria P cobalamin synthesis protein - - - - - - - - - - - - CobW_C,cobW k59_244639_1 1367491.BN865_06850c 4.27e-28 118.0 COG0463@1|root,COG1887@1|root,COG0463@2|Bacteria,COG1887@2|Bacteria,1MU66@1224|Proteobacteria,42NYK@68525|delta/epsilon subdivisions,2YMXQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - - - - - - - - - - - Glycos_transf_2,Glyphos_transf k59_997196_2 395493.BegalDRAFT_2838 2.79e-13 64.7 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,46133@72273|Thiotrichales 72273|Thiotrichales J Sigma 54 modulation protein yhbH - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_244641_1 1235790.C805_03116 2.95e-156 452.0 COG3547@1|root,COG3547@2|Bacteria,1TP4A@1239|Firmicutes,24A2F@186801|Clostridia,25VFW@186806|Eubacteriaceae 186801|Clostridia L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_931842_1 1168034.FH5T_08815 1.17e-95 308.0 COG1729@1|root,COG1729@2|Bacteria,4PKGA@976|Bacteroidetes,2G3G6@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 k59_309433_1 1278309.KB907100_gene2322 2.54e-82 257.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XHXR@135619|Oceanospirillales 135619|Oceanospirillales Q TRAP-type mannitol chloroaromatic compound transport system, large permease component gtrB - - - - - - - - - - - DctM k59_865394_1 1237149.C900_04559 0.000221 42.7 COG0745@1|root,COG0745@2|Bacteria,4NIQC@976|Bacteroidetes,47PDQ@768503|Cytophagia 976|Bacteroidetes T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_865394_2 97137.C821_00188 3.06e-36 143.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,3F45G@33958|Lactobacillaceae 91061|Bacilli T Histidine kinase vicK - 2.7.13.3 ko:K07652 ko02020,map02020 M00459 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_9 k59_375737_1 1168034.FH5T_14340 7.54e-82 254.0 COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,2FMB0@200643|Bacteroidia 976|Bacteroidetes G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos k59_309447_1 1249627.D779_3942 2.52e-18 84.7 COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria 1224|Proteobacteria M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_309447_2 323261.Noc_2665 1.01e-49 177.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_180613_2 1500281.JQKZ01000006_gene3697 1.4e-22 96.3 COG2755@1|root,COG2755@2|Bacteria,4NEG4@976|Bacteroidetes,1HYWW@117743|Flavobacteriia,3ZRAC@59732|Chryseobacterium 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_572043_1 1168034.FH5T_16860 1.57e-50 173.0 COG2986@1|root,COG2986@2|Bacteria,4NE0D@976|Bacteroidetes,2FMCF@200643|Bacteroidia 976|Bacteroidetes E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_507917_1 1041146.ATZB01000008_gene2192 1.28e-66 223.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_997221_1 572544.Ilyop_0628 3.91e-278 773.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,378BF@32066|Fusobacteria 2|Bacteria C PFAM hydrogenase large subunit domain protein hndD - 1.12.1.2,1.12.1.3,1.6.5.3 ko:K00336,ko:K18006,ko:K18332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iHN637.CLJU_RS07205 Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3 k59_507920_1 351016.RAZWK3B_19111 4.02e-65 220.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,2P2HK@2433|Roseobacter 28211|Alphaproteobacteria P COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1028706_1 1537917.JU82_01815 8.2e-37 126.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2YP73@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_997974_1 768671.ThimaDRAFT_1430 4.39e-109 323.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1WW7U@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_213834_1 768671.ThimaDRAFT_3029 4.71e-107 331.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1X2UG@135613|Chromatiales 135613|Chromatiales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_833925_1 880072.Desac_0166 2.93e-61 204.0 COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MRHT@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit - - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Prismane k59_1029454_1 472759.Nhal_1062 1.85e-47 164.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1WW1A@135613|Chromatiales 135613|Chromatiales S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_734904_1 1249480.B649_10915 2.86e-89 272.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2YMXT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_734904_2 1249480.B649_10910 4.62e-19 85.9 COG2857@1|root,COG2857@2|Bacteria,1PX4N@1224|Proteobacteria,42MFF@68525|delta/epsilon subdivisions,2YMBA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C ubiquinol cytochrome c oxidoreductase, cytochrome c1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - iIT341.HP1538 Cytochrom_C,Cytochrom_C1 k59_797774_1 572480.Arnit_2986 9.47e-116 341.0 COG0338@1|root,COG0338@2|Bacteria,1P85S@1224|Proteobacteria,42RAF@68525|delta/epsilon subdivisions,2YP2J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Site-specific DNA-methyltransferase (Adenine-specific) - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_797775_1 314278.NB231_11094 4.75e-39 140.0 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,1S24F@1236|Gammaproteobacteria,1X0ME@135613|Chromatiales 135613|Chromatiales S phospholipase Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_82088_1 1245469.S58_22090 1.23e-08 57.0 COG1116@1|root,COG1116@2|Bacteria,1R53G@1224|Proteobacteria,2U0HV@28211|Alphaproteobacteria,3JV4G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P ABC transporter atsC - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_82088_2 626887.J057_08586 5.46e-31 122.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,1S25T@1236|Gammaproteobacteria,46AP6@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes blaB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B,NUDIX k59_605995_1 765911.Thivi_1380 5.91e-18 84.7 COG1639@1|root,COG1639@2|Bacteria,1MXVB@1224|Proteobacteria,1RMNV@1236|Gammaproteobacteria,1WZ5H@135613|Chromatiales 135613|Chromatiales T Signal transduction protein - - - - - - - - - - - - HDOD k59_671574_1 985255.APHJ01000039_gene145 1.09e-47 162.0 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1HX46@117743|Flavobacteriia,2P6F3@244698|Gillisia 976|Bacteroidetes M Peptidase family M23 mepM_1 - - - - - - - - - - - Peptidase_M23 k59_671574_2 746697.Aeqsu_1803 1.14e-27 111.0 COG0013@1|root,COG0013@2|Bacteria,4NFHW@976|Bacteroidetes,1HXDT@117743|Flavobacteriia 976|Bacteroidetes J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_671576_1 1267005.KB911257_gene1029 1.35e-98 299.0 COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,2V700@28211|Alphaproteobacteria,3N8NH@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria L Helicase - - - - - - - - - - - - Herpes_Helicase,PIF1 k59_671577_1 153948.NAL212_2955 2.61e-95 285.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,372VZ@32003|Nitrosomonadales 28216|Betaproteobacteria L PFAM Integrase, catalytic - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_408788_1 990073.ATHU01000001_gene1798 4.15e-27 101.0 COG0633@1|root,COG0633@2|Bacteria,1PSR6@1224|Proteobacteria,42XGK@68525|delta/epsilon subdivisions,2YQWI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - Fer2 k59_408788_2 709032.Sulku_1304 1.23e-56 176.0 COG0633@1|root,COG0633@2|Bacteria,1NJF0@1224|Proteobacteria,42U1V@68525|delta/epsilon subdivisions,2YQ25@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - Fer2 k59_276724_2 97139.C824_02518 2.46e-05 51.2 COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,36E95@31979|Clostridiaceae 186801|Clostridia J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_638464_1 1168034.FH5T_09980 6.65e-56 181.0 29A93@1|root,32UVK@2|Bacteria,4NTR2@976|Bacteroidetes,2G3DP@200643|Bacteroidia 976|Bacteroidetes S Psort location OuterMembrane, score - - - - - - - - - - - - Gcw_chp k59_181407_2 746697.Aeqsu_0635 1.33e-42 142.0 COG0526@1|root,COG0526@2|Bacteria,4NQ50@976|Bacteroidetes,1I2VW@117743|Flavobacteriia 976|Bacteroidetes CO Thiol-disulfide isomerase - - - - - - - - - - - - Thioredoxin_7 k59_734922_1 56780.SYN_01028 6.27e-10 64.7 COG2197@1|root,COG2197@2|Bacteria,1R3YQ@1224|Proteobacteria,42WAE@68525|delta/epsilon subdivisions,2WRWH@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM regulatory protein LuxR - - - - - - - - - - - - GerE,PAS_9 k59_345091_1 1121918.ARWE01000001_gene2982 3.83e-72 245.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,43TI4@69541|Desulfuromonadales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_932677_1 96561.Dole_0439 1.96e-58 191.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,42P1T@68525|delta/epsilon subdivisions,2WKZB@28221|Deltaproteobacteria,2MI0P@213118|Desulfobacterales 28221|Deltaproteobacteria F TIGRFAM deoxyguanosinetriphosphate triphosphohydrolase - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_11675_2 306263.Cla_a025 1.64e-31 121.0 2AJFB@1|root,31A1K@2|Bacteria,1Q4P0@1224|Proteobacteria,42ZJ3@68525|delta/epsilon subdivisions,2YRPF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_998014_2 29581.BW37_04142 2.44e-41 143.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VJMC@28216|Betaproteobacteria,472YT@75682|Oxalobacteraceae 28216|Betaproteobacteria S Belongs to the WrbA family wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_606030_1 1317122.ATO12_24585 1.34e-15 75.5 COG1988@1|root,COG1988@2|Bacteria,4NPMW@976|Bacteroidetes,1I2P2@117743|Flavobacteriia,2YIQT@290174|Aquimarina 976|Bacteroidetes S LexA-binding, inner membrane-associated putative hydrolase - - - ko:K07038 - - - - ko00000 - - - YdjM k59_577356_2 1476390.A0A060RFK4_9CAUD 7.09e-42 142.0 4QCR9@10239|Viruses,4QZ7A@35237|dsDNA viruses no RNA stage,4QT36@28883|Caudovirales,4QKZZ@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_577356_3 1132026.I6NQ53_9CAUD 3.38e-11 62.4 4QGHF@10239|Viruses,4QSX2@28883|Caudovirales,4QMFB@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_802304_1 941449.dsx2_0705 3e-60 200.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,42S77@68525|delta/epsilon subdivisions,2X5PF@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Biotin-lipoyl like - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_D23 k59_380970_1 927658.AJUM01000042_gene1731 5.94e-46 166.0 COG2207@1|root,COG2207@2|Bacteria,4NIIK@976|Bacteroidetes,2G2V3@200643|Bacteroidia,3XKFN@558415|Marinilabiliaceae 976|Bacteroidetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18,Reg_prop,Y_Y_Y k59_707748_1 563040.Saut_0376 2.59e-77 251.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2YNGB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member recD - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2,Viral_helicase1 k59_772987_1 1121403.AUCV01000014_gene4632 4.41e-106 313.0 COG0535@1|root,COG0535@2|Bacteria,1R6IV@1224|Proteobacteria,42YE7@68525|delta/epsilon subdivisions,2WU7H@28221|Deltaproteobacteria,2MMU0@213118|Desulfobacterales 28221|Deltaproteobacteria S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12 k59_16346_1 930169.B5T_02239 6.11e-80 249.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria,1XIW9@135619|Oceanospirillales 135619|Oceanospirillales OU peptidase sohB - - ko:K04774 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49,Peptidase_S49_N k59_281107_1 572544.Ilyop_1880 1.09e-91 288.0 COG0210@1|root,COG0210@2|Bacteria 2|Bacteria L ATP-dependent DNA helicase activity - - 3.1.11.5,3.6.4.12 ko:K03582,ko:K03657 ko03420,ko03430,ko03440,map03420,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_642883_1 1165841.SULAR_08107 8.18e-11 68.2 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind k59_707754_1 760154.Sulba_1013 7.22e-42 140.0 COG0633@1|root,COG0633@2|Bacteria,1PSR6@1224|Proteobacteria,42XGK@68525|delta/epsilon subdivisions,2YQWI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - Fer2 k59_707754_2 1123326.JFBL01000001_gene1341 2.08e-57 178.0 COG0633@1|root,COG0633@2|Bacteria,1NJF0@1224|Proteobacteria,42U1V@68525|delta/epsilon subdivisions,2YQ25@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - Fer2 k59_51992_1 1269813.ATUL01000021_gene748 5.16e-59 191.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales 135613|Chromatiales C PFAM Phosphoribulokinase uridine kinase - - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_314592_1 765912.Thimo_1053 7.99e-65 218.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_478415_1 1249480.B649_02015 2.92e-52 182.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2YMEZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thiol disulfide interchange protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7 k59_937031_1 1121920.AUAU01000006_gene396 1.2e-94 295.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria 57723|Acidobacteria EU Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 k59_413129_1 1172190.M947_09110 4.04e-62 196.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2YNC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U MotA TolQ ExbB proton channel family tolQ - - - - - - - - - - - MotA_ExbB k59_413129_2 1172190.M947_09105 2.91e-57 181.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2YPZU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U transport protein tolR - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_413129_3 1172190.M947_09100 6.7e-29 116.0 COG0810@1|root,COG0810@2|Bacteria,1QAAM@1224|Proteobacteria,42X9R@68525|delta/epsilon subdivisions,2YQQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2 k59_413129_4 929558.SMGD1_2277 1.06e-19 89.4 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2YMQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_772996_1 1049564.TevJSym_bn00090 4.43e-59 192.0 COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Periplasmic protein TonB links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_185845_1 572544.Ilyop_1477 6.4e-88 266.0 COG4974@1|root,COG4974@2|Bacteria,379Q6@32066|Fusobacteria 32066|Fusobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_676252_1 713587.THITH_03075 8.21e-28 105.0 2D6KW@1|root,32TMI@2|Bacteria,1QVSZ@1224|Proteobacteria,1SIEK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF4255) - - - - - - - - - - - - DUF4255 k59_676252_2 498211.CJA_3055 3.04e-40 144.0 2EETY@1|root,338MF@2|Bacteria,1NEVS@1224|Proteobacteria,1SQ3Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_250752_2 864069.MicloDRAFT_00007220 6.93e-206 582.0 COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,1JT4U@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_281832_1 1121011.AUCB01000027_gene3026 2.18e-43 155.0 COG3344@1|root,COG3344@2|Bacteria,4NHMS@976|Bacteroidetes,1HZPH@117743|Flavobacteriia,23GCY@178469|Arenibacter 976|Bacteroidetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_153990_1 1242969.ATCC51562_1727 1.22e-43 155.0 COG0614@1|root,COG0614@2|Bacteria,1NVK4@1224|Proteobacteria,42MBT@68525|delta/epsilon subdivisions,2YMTN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_937871_1 1120970.AUBZ01000019_gene3563 3.4e-178 506.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,465AR@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nrtC - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_17056_1 877415.JNJQ01000009_gene983 4.81e-38 146.0 28HFK@1|root,2Z7RM@2|Bacteria,1TP86@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_904622_2 1249627.D779_0601 2.75e-68 222.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_413881_1 1123261.AXDW01000005_gene2602 6.98e-08 53.5 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1X45G@135614|Xanthomonadales 135614|Xanthomonadales E Acetolactate synthase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_413881_2 388401.RB2150_05143 8.17e-82 259.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,3ZGX4@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria P COG2059 Chromate transport protein ChrA - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_87444_1 288000.BBta_1460 4.59e-280 782.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_937877_1 880073.Calab_1879 1.85e-07 50.1 COG0432@1|root,COG0432@2|Bacteria,2NPSI@2323|unclassified Bacteria 2|Bacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_937877_2 96561.Dole_0464 1.08e-53 172.0 COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,42RM4@68525|delta/epsilon subdivisions,2WNU8@28221|Deltaproteobacteria,2MJYM@213118|Desulfobacterales 28221|Deltaproteobacteria K AsnC-type helix-turn-helix domain nirD - - - - - - - - - - - HTH_AsnC-type k59_740041_1 1172190.M947_02140 4.01e-25 100.0 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2YNYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Hemolysin tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_740041_2 1249480.B649_08015 5.52e-56 182.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2YMFH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_871330_2 1155718.KB891855_gene92 2.33e-15 82.8 COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria 201174|Actinobacteria E asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_315339_1 944547.ABLL_2114 1.14e-85 278.0 COG4774@1|root,COG4774@2|Bacteria,1QU2Y@1224|Proteobacteria,43CFU@68525|delta/epsilon subdivisions,2YTF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M PFAM TonB-dependent Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - TonB_dep_Rec k59_350315_1 880073.Calab_1598 2.19e-67 228.0 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria 2|Bacteria P Prokaryotic cytochrome b561 cbcY - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese k59_446288_1 1265490.JHVY01000030_gene4503 1.45e-52 177.0 28M6B@1|root,2ZAJZ@2|Bacteria,1NY46@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_514066_1 566466.NOR53_1509 1.02e-97 306.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1S0CZ@1236|Gammaproteobacteria,1J9C3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C related to penicillin acylase - - 3.5.1.97 ko:K07116 - - - - ko00000,ko01000 - - - Penicil_amidase k59_677060_1 457424.BFAG_03036 7.55e-21 94.7 COG0167@1|root,COG0167@2|Bacteria,4NF4D@976|Bacteroidetes,2FM0X@200643|Bacteroidia,4AKRJ@815|Bacteroidaceae 976|Bacteroidetes F Catalyzes the conversion of dihydroorotate to orotate preA - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_578117_1 580332.Slit_0818 3.98e-23 97.4 COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,2VWPY@28216|Betaproteobacteria 28216|Betaproteobacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_578117_2 1049564.TevJSym_bn00220 2.51e-14 72.4 COG1638@1|root,COG1638@2|Bacteria 2|Bacteria G carbohydrate transport - - - ko:K11688,ko:K21395 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_1034544_1 479437.Elen_3114 6.51e-43 153.0 COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4CU9A@84998|Coriobacteriia 84998|Coriobacteriia F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_446297_1 631362.Thi970DRAFT_02916 7.79e-103 315.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales 135613|Chromatiales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_970162_1 1500890.JQNL01000001_gene2666 2.5e-30 119.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,1X5C9@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_970162_2 868864.Dester_1083 7e-05 47.0 COG0340@1|root,COG0340@2|Bacteria,2G45T@200783|Aquificae 200783|Aquificae H biotin acetyl-CoA-carboxylase ligase birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_381751_1 1121459.AQXE01000012_gene2300 1.25e-63 211.0 COG3075@1|root,COG3075@2|Bacteria,1MU3K@1224|Proteobacteria,42Q09@68525|delta/epsilon subdivisions,2WKE0@28221|Deltaproteobacteria,2M7WY@213115|Desulfovibrionales 28221|Deltaproteobacteria E Glycerol-3-phosphate dehydrogenase, anaerobic, B subunit glpB - 1.1.5.3 ko:K00112 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_250785_1 1537917.JU82_07125 1.93e-64 204.0 COG1413@1|root,COG1413@2|Bacteria,1NMDT@1224|Proteobacteria,42WYR@68525|delta/epsilon subdivisions,2YQSX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C lyase activity - - - - - - - - - - - - - k59_446301_1 1116472.MGMO_8c00260 1.18e-36 134.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1S0QX@1236|Gammaproteobacteria,1XGCX@135618|Methylococcales 135618|Methylococcales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_578122_2 1537917.JU82_09915 7.5e-12 64.7 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2YMIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LU DNA processing protein dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_643742_1 1449350.OCH239_20365 3.27e-49 167.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_186627_1 572544.Ilyop_1339 6.93e-117 351.0 COG1283@1|root,COG1283@2|Bacteria,378CQ@32066|Fusobacteria 32066|Fusobacteria P Na Pi-cotransporter II-like protein - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_1003295_1 768670.Calni_0147 1.19e-77 254.0 COG0326@1|root,COG0326@2|Bacteria,2GF3F@200930|Deferribacteres 200930|Deferribacteres O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c_3,HSP90 k59_1003295_2 1232446.BAIE02000031_gene2726 3.93e-26 119.0 COG0840@1|root,COG2199@1|root,COG0840@2|Bacteria,COG3706@2|Bacteria,1V1RJ@1239|Firmicutes,24G3N@186801|Clostridia 186801|Clostridia T Single cache domain 3 - - - - - - - - - - - - GGDEF,sCache_3_3 k59_1003295_3 1392491.JIAE01000001_gene1689 3.87e-27 105.0 COG0494@1|root,COG0494@2|Bacteria,1UHVA@1239|Firmicutes,24PC0@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_1003295_4 519441.Smon_0949 5.32e-78 251.0 COG0692@1|root,COG0692@2|Bacteria,37911@32066|Fusobacteria 32066|Fusobacteria L K03648 uracil-DNA glycosylase - - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_87478_1 1121875.KB907556_gene591 8.08e-74 237.0 COG1473@1|root,COG1473@2|Bacteria,4NEKH@976|Bacteroidetes,1HZT3@117743|Flavobacteriia 976|Bacteroidetes S PFAM Peptidase M20 - - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 k59_514100_1 1300345.LF41_3143 3.43e-53 183.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X393@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the cysteine synthase cystathionine beta- synthase family - - - - - - - - - - - - PALP k59_611127_1 1453505.JASY01000001_gene3646 3.12e-40 143.0 COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,1HZ28@117743|Flavobacteriia,2NZZR@237|Flavobacterium 976|Bacteroidetes L Integrase core domain - - - - - - - - - - - - rve,rve_3 k59_514102_2 768066.HELO_4002 2.18e-47 169.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_281893_1 1165841.SULAR_10644 8.43e-110 325.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2YNZT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_281893_2 1150621.SMUL_0133 2.09e-41 141.0 COG0597@1|root,COG0597@2|Bacteria,1Q1GU@1224|Proteobacteria,42TMD@68525|delta/epsilon subdivisions,2YPZS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_17135_1 926550.CLDAP_31450 1.38e-36 139.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G5Y5@200795|Chloroflexi 200795|Chloroflexi M PFAM sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_839257_1 1168034.FH5T_11385 2.1e-124 362.0 COG0196@1|root,COG0196@2|Bacteria,4NEI9@976|Bacteroidetes,2FM7A@200643|Bacteroidia 976|Bacteroidetes H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_839257_2 1168034.FH5T_11380 5.53e-34 125.0 COG3568@1|root,COG3568@2|Bacteria,4NGUV@976|Bacteroidetes,2FNIX@200643|Bacteroidia 976|Bacteroidetes S endonuclease exonuclease phosphatase family protein - - - - - - - - - - - - Exo_endo_phos k59_545731_1 469610.HMPREF0189_01553 7.72e-118 363.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1KK29@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_871382_1 42565.FP66_16150 2.05e-48 160.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XJQK@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_871382_2 519989.ECTPHS_12983 1.86e-38 135.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1WWNN@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine - - 2.4.2.28,2.4.2.44 ko:K00772,ko:K19696 ko00270,ko01100,map00270,map01100 M00034 R01402,R09668 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_315407_1 472759.Nhal_0545 1.11e-181 520.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales 135613|Chromatiales J TIGRFAM ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_677116_1 1121403.AUCV01000013_gene3911 1.1e-13 73.9 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_677116_2 1163617.SCD_n02930 1.91e-15 74.7 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2VRJN@28216|Betaproteobacteria 28216|Betaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_937925_1 1537917.JU82_01000 2.63e-163 470.0 COG1956@1|root,COG3604@1|root,COG1956@2|Bacteria,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2YNEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF_2,HTH_8,Sigma54_activat k59_803150_1 1121430.JMLG01000001_gene2336 1.04e-32 131.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,263P9@186807|Peptococcaceae 186801|Clostridia E Pyridine nucleotide-disulphide oxidoreductase sfrB - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2 k59_479319_1 1545915.JROG01000004_gene1986 1.24e-06 53.1 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria,2K0DH@204457|Sphingomonadales 204457|Sphingomonadales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23 k59_281914_1 1158345.JNLL01000001_gene1255 2.56e-107 336.0 COG0243@1|root,COG0243@2|Bacteria,2G4F5@200783|Aquificae 200783|Aquificae C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.7.2 ko:K00367,ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530,M00531 R00791,R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_250832_1 1303692.SFUL_850 2.17e-36 133.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Methyltransf_25 k59_52839_1 598659.NAMH_0996 7.55e-73 239.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2YMVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_545748_1 177437.HRM2_01750 8.8e-90 278.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MHPU@213118|Desulfobacterales 28221|Deltaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_803154_1 1172190.M947_00620 7.64e-101 301.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2YMA2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L hydrolase, TatD tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_578150_1 399549.Msed_1939 4.87e-20 89.7 COG2096@1|root,arCOG00489@2157|Archaea,2XQXF@28889|Crenarchaeota 28889|Crenarchaeota H PFAM Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_942196_1 768671.ThimaDRAFT_2793 4.31e-114 340.0 COG3039@1|root,COG3039@2|Bacteria,1P2FY@1224|Proteobacteria,1SRZF@1236|Gammaproteobacteria,1X1EC@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_582892_1 572544.Ilyop_0009 6.04e-47 162.0 COG0589@1|root,COG0589@2|Bacteria,37A4M@32066|Fusobacteria 32066|Fusobacteria T Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_582892_2 572544.Ilyop_0007 3.52e-53 187.0 COG0188@1|root,COG0188@2|Bacteria,3787P@32066|Fusobacteria 32066|Fusobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_615507_1 1537917.JU82_00535 1.46e-88 273.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2YMNB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_615507_2 1172190.M947_11200 9.34e-15 70.1 COG0597@1|root,COG0597@2|Bacteria,1Q1GU@1224|Proteobacteria,42TMD@68525|delta/epsilon subdivisions,2YPZS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_354337_1 1172190.M947_02715 1.5e-119 355.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2YMUF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_354337_2 929558.SMGD1_1220 2.35e-11 63.5 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2YMWQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_354354_2 358220.C380_01315 1.31e-24 104.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,4ABCX@80864|Comamonadaceae 28216|Betaproteobacteria V TIGRFAM type I secretion system ATPase - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_57435_1 1454004.AW11_00535 1.38e-70 233.0 COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,2VKTF@28216|Betaproteobacteria 28216|Betaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_1007347_1 1168034.FH5T_07405 3.72e-71 237.0 COG0038@1|root,COG0038@2|Bacteria,4NZYS@976|Bacteroidetes,2G0DB@200643|Bacteroidia 976|Bacteroidetes P Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 k59_648375_1 572544.Ilyop_1571 1.42e-101 311.0 COG1866@1|root,COG1866@2|Bacteria 2|Bacteria H phosphoenolpyruvate carboxykinase (ATP) activity pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_159231_1 1347368.HG964403_gene4506 4.5e-06 50.8 COG0515@1|root,COG0642@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1UNM0@1239|Firmicutes,4IUHS@91061|Bacilli,1ZSGA@1386|Bacillus 91061|Bacilli KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_807379_1 471854.Dfer_4443 1.29e-05 49.3 COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,47PZA@768503|Cytophagia 976|Bacteroidetes L Integrase core domain - - - - - - - - - - - - rve,rve_3 k59_451379_1 977880.RALTA_A3035 1.85e-58 187.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VHMC@28216|Betaproteobacteria,1K2Q4@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM beta-lactamase domain protein ycbL - - - - - - - - - - - Lactamase_B k59_418055_1 1168034.FH5T_15200 6.7e-34 132.0 2DM3I@1|root,31JQ3@2|Bacteria,4NRM4@976|Bacteroidetes,2FM1R@200643|Bacteroidia 976|Bacteroidetes S Psort location OuterMembrane, score - - - - - - - - - - - - - k59_223415_1 977880.RALTA_A0875 1.39e-49 168.0 COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,2VJMU@28216|Betaproteobacteria,1JZRF@119060|Burkholderiaceae 28216|Betaproteobacteria EG EamA-like transporter family eamA1 - - - - - - - - - - - EamA k59_582917_1 472175.EL18_01955 8.31e-09 62.8 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U0ME@28211|Alphaproteobacteria,43QDB@69277|Phyllobacteriaceae 28211|Alphaproteobacteria N Integrin alpha (beta-propellor repeats). exsH - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Glyco_hydro_16,HemolysinCabind,W_rich_C k59_518893_2 42256.RradSPS_2936 1.6e-35 134.0 COG1156@1|root,COG1156@2|Bacteria,2I4C0@201174|Actinobacteria 201174|Actinobacteria C ATP synthase alpha/beta family, beta-barrel domain - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_974154_1 187272.Mlg_0587 2.87e-36 139.0 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_942218_1 395493.BegalDRAFT_1645 1.08e-29 115.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,460FP@72273|Thiotrichales 72273|Thiotrichales F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1039655_1 765914.ThisiDRAFT_2568 7.51e-18 80.1 COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,1S8TQ@1236|Gammaproteobacteria,1WYGU@135613|Chromatiales 135613|Chromatiales N flagellar protein FliS - - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k59_1039655_2 228410.NE1595 7.77e-19 88.6 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,2VHMK@28216|Betaproteobacteria,371U5@32003|Nitrosomonadales 28216|Betaproteobacteria N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_681289_1 765913.ThidrDRAFT_2991 2.19e-19 79.7 2AJN3@1|root,31A9F@2|Bacteria,1QMVM@1224|Proteobacteria,1TK62@1236|Gammaproteobacteria,1WZRM@135613|Chromatiales 135613|Chromatiales S Cysteine-rich CPXCG - - - - - - - - - - - - Cys_rich_CPXG k59_681289_2 314345.SPV1_09583 1.41e-97 308.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria 1224|Proteobacteria P ATPase, P-type transporting, HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_57483_1 572477.Alvin_2057 7.02e-74 234.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1WY1X@135613|Chromatiales 135613|Chromatiales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_92344_1 1198232.CYCME_1560 1.17e-27 106.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria,460JP@72273|Thiotrichales 72273|Thiotrichales S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_92344_2 1121935.AQXX01000123_gene226 1.47e-24 103.0 COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1XJ9X@135619|Oceanospirillales 135619|Oceanospirillales DM COG0739 Membrane proteins related to metalloendopeptidases nlpD - - ko:K06194 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_57489_1 545276.KB898727_gene381 1.79e-07 52.8 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales 135613|Chromatiales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_57489_2 1411685.U062_00212 4.04e-36 132.0 COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,1SA30@1236|Gammaproteobacteria,1J6NG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog rpoE1 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_286720_1 1121439.dsat_2181 2.42e-64 206.0 COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria,2MBMN@213115|Desulfovibrionales 28221|Deltaproteobacteria C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_681301_1 1168034.FH5T_07345 1.37e-89 272.0 COG1215@1|root,COG1215@2|Bacteria,4PKM6@976|Bacteroidetes,2FTHH@200643|Bacteroidia 976|Bacteroidetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_57505_1 1349822.NSB1T_01635 1.48e-37 142.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,2FMQ9@200643|Bacteroidia,22WY7@171551|Porphyromonadaceae 976|Bacteroidetes G Glycosyl hydrolase family 92 - - - - - - - - - - - - Glyco_hydro_92 k59_713046_1 631362.Thi970DRAFT_03602 4.3e-141 409.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales 135613|Chromatiales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_1039672_1 335543.Sfum_1435 6.12e-69 229.0 COG1032@1|root,COG1032@2|Bacteria,1R52J@1224|Proteobacteria,42P9G@68525|delta/epsilon subdivisions,2WKFU@28221|Deltaproteobacteria,2MRU9@213462|Syntrophobacterales 28221|Deltaproteobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM k59_354402_1 1265502.KB905944_gene699 4.41e-28 106.0 COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2VQBI@28216|Betaproteobacteria,4AEP7@80864|Comamonadaceae 28216|Betaproteobacteria S NnrU protein nnrU - - - - - - - - - - - NnrU k59_1039676_1 929558.SMGD1_0870 5.9e-118 351.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2YM91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_386869_1 1411123.JQNH01000001_gene2252 1.55e-74 230.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_550442_1 879212.DespoDRAFT_01244 1.61e-58 185.0 COG0432@1|root,COG0432@2|Bacteria,1N5SN@1224|Proteobacteria,42SJC@68525|delta/epsilon subdivisions,2WP9F@28221|Deltaproteobacteria,2MK51@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_57525_1 395493.BegalDRAFT_1422 1.87e-13 70.5 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,45ZPA@72273|Thiotrichales 72273|Thiotrichales F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_57525_2 519989.ECTPHS_06997 1.6e-47 156.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales 135613|Chromatiales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_518914_1 886379.AEWI01000208_gene2428 1.1e-07 52.8 COG0454@1|root,COG0456@2|Bacteria,4NNUU@976|Bacteroidetes,2FSZA@200643|Bacteroidia,3XJ5B@558415|Marinilabiliaceae 976|Bacteroidetes K Acetyltransferase (GNAT) family - - 2.3.1.264 ko:K21935 - - R11701 - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_10 k59_518914_2 1319815.HMPREF0202_00070 4.12e-21 91.7 COG0010@1|root,COG1982@1|root,COG0010@2|Bacteria,COG1982@2|Bacteria,379MA@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Arginase,OKR_DC_1,OKR_DC_1_C k59_57533_1 694427.Palpr_1531 6.44e-62 201.0 COG1575@1|root,COG1575@2|Bacteria,4NGCJ@976|Bacteroidetes,2FMMX@200643|Bacteroidia,22XUQ@171551|Porphyromonadaceae 976|Bacteroidetes H Belongs to the MenA family. Type 1 subfamily menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_1007405_1 857087.Metme_3833 2.38e-95 286.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1XDXQ@135618|Methylococcales 135618|Methylococcales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_778375_1 517417.Cpar_1412 5.66e-38 145.0 COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1FEI6@1090|Chlorobi 1090|Chlorobi C PFAM NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - - ko:K05565 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,Proton_antipo_M,Proton_antipo_N k59_713070_1 1049564.TevJSym_ad01710 6.03e-76 233.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,1J6FA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479 ABC_tran k59_159309_1 1168034.FH5T_04315 1.94e-106 311.0 COG0545@1|root,COG0545@2|Bacteria,4NDW4@976|Bacteroidetes,2FNCK@200643|Bacteroidia 976|Bacteroidetes O Peptidyl-prolyl cis-trans isomerase fklB - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_159309_2 1168034.FH5T_04320 4.42e-62 197.0 COG0545@1|root,COG0545@2|Bacteria,4NDW4@976|Bacteroidetes,2G31Y@200643|Bacteroidia 976|Bacteroidetes M Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_681345_1 326298.Suden_0409 2.47e-50 174.0 COG4968@1|root,COG4968@2|Bacteria,1QUIY@1224|Proteobacteria,42S53@68525|delta/epsilon subdivisions,2YPC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prepilin-type N-terminal cleavage methylation domain - - - - - - - - - - - - N_methyl k59_807447_1 391616.OA238_c43530 6.95e-54 193.0 COG1404@1|root,COG1404@2|Bacteria,1RCVP@1224|Proteobacteria,2UK1F@28211|Alphaproteobacteria 28211|Alphaproteobacteria MO outer membrane autotransporter barrel domain protein - - - - - - - - - - - - - k59_843305_1 629265.PMA4326_02112 1.68e-21 95.1 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,1S0UK@1236|Gammaproteobacteria,1Z5WK@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_843307_1 2340.JV46_29200 2.68e-64 206.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1J4GM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_778405_1 1158318.ATXC01000001_gene1083 3.93e-36 137.0 COG3303@1|root,COG3303@2|Bacteria,2G4ZH@200783|Aquificae 200783|Aquificae P Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto k59_908823_1 1150469.RSPPHO_00678 8.38e-52 184.0 COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2TU5K@28211|Alphaproteobacteria,2JQRQ@204441|Rhodospirillales 204441|Rhodospirillales J Specifically methylates the adenine in position 2030 of 23S rRNA rlmJ - 2.1.1.266 ko:K07115 - - - - ko00000,ko01000,ko03009 - - - RsmJ k59_908836_1 1437882.AZRU01000012_gene3504 3.4e-87 277.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1YF1J@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_125138_1 1500894.JQNN01000001_gene1158 7.33e-68 223.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,472TV@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain alkK - 6.2.1.44 ko:K00666,ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_908838_2 523845.AQXV01000027_gene1199 0.000122 43.9 COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,23Q91@183939|Methanococci 183939|Methanococci S CBS domain containing protein - - - - - - - - - - - - CBS,HcyBio k59_57563_1 765913.ThidrDRAFT_1560 1.79e-81 258.0 COG0772@1|root,COG0772@2|Bacteria,1R537@1224|Proteobacteria,1RR9J@1236|Gammaproteobacteria,1WWS3@135613|Chromatiales 135613|Chromatiales D Belongs to the SEDS family - - - - - - - - - - - - FTSW_RODA_SPOVE k59_778429_1 388399.SSE37_03005 4.72e-31 120.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2U450@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG0631 Serine threonine protein phosphatase - - 3.1.3.16 ko:K01090,ko:K11915,ko:K20074 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01009,ko02044 - - - PP2C,PP2C_2 k59_191127_2 156889.Mmc1_1698 7.33e-27 109.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - 2.4.1.266 ko:K09118,ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - Usp k59_319519_1 715451.ambt_14275 5.97e-21 93.2 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RSG9@1236|Gammaproteobacteria,464W2@72275|Alteromonadaceae 1236|Gammaproteobacteria E aminopeptidase pepN - - - - - - - - - - - Leuk-A4-hydro_C,Peptidase_M1 k59_319519_2 566466.NOR53_3178 4.23e-28 105.0 2E4PM@1|root,32P93@2|Bacteria,1N4SK@1224|Proteobacteria,1SEXN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_681382_1 314345.SPV1_09518 9.61e-19 82.8 COG2905@1|root,COG2905@2|Bacteria 2|Bacteria T signal-transduction protein containing cAMP-binding and CBS domains kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_615639_1 1123073.KB899242_gene917 6.06e-55 187.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1X41G@135614|Xanthomonadales 135614|Xanthomonadales L Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates sbcB - 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_582967_1 1487953.JMKF01000025_gene2357 4.75e-90 268.0 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1H72I@1150|Oscillatoriales 1117|Cyanobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_319525_1 1537917.JU82_02410 2.17e-131 384.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2YMAG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_319525_2 1244531.CIG1485E_1407 3.5e-22 95.9 COG3660@1|root,COG3660@2|Bacteria,1RC47@1224|Proteobacteria,42R32@68525|delta/epsilon subdivisions,2YNVT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mitochondrial fission ELM1 - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_92407_1 1122201.AUAZ01000012_gene1414 1.3e-41 154.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,464U2@72275|Alteromonadaceae 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_354434_1 454957.IA64_05125 2.67e-13 76.3 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales 135614|Xanthomonadales T Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_57574_1 1537917.JU82_07115 5.15e-152 455.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,43BQI@68525|delta/epsilon subdivisions,2YRHF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K17050 - - - - ko00000,ko02000 5.A.3.8 - - Molybdopterin,Molydop_binding k59_482974_1 1318628.MARLIPOL_11111 2.44e-12 68.9 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria,46A3S@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG1126 ABC-type polar amino acid transport system, ATPase component tcyC - 3.6.3.21 ko:K02028,ko:K02029,ko:K10010,ko:K16960,ko:K16963 ko02010,map02010 M00234,M00236,M00585,M00586 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.13,3.A.1.3.14 - - ABC_tran k59_582973_1 414684.RC1_1041 1.06e-28 107.0 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,2JT97@204441|Rhodospirillales 204441|Rhodospirillales U Preprotein translocase subunit YajC yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_582973_2 34506.g3105 8.02e-14 71.6 COG0343@1|root,KOG3908@2759|Eukaryota,38H9M@33154|Opisthokonta,3BB83@33208|Metazoa,3CT6A@33213|Bilateria,40C8R@6231|Nematoda,1KUK2@119089|Chromadorea,414R9@6236|Rhabditida 33208|Metazoa A Queuine tRNA-ribosyltransferase - - - - - - - - - - - - TGT k59_1040595_1 1046714.AMRX01000001_gene1218 3.6e-67 221.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,4641Y@72275|Alteromonadaceae 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_519854_1 455436.DS989810_gene21 9.53e-86 279.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,464J4@72275|Alteromonadaceae 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_256223_1 208596.CAR_c20850 4.75e-93 280.0 COG0546@1|root,COG0546@2|Bacteria,1V1RB@1239|Firmicutes,4HGQW@91061|Bacilli,27GPI@186828|Carnobacteriaceae 91061|Bacilli S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_256223_2 208596.CAR_c21150 6.09e-178 510.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,27H8H@186828|Carnobacteriaceae 91061|Bacilli G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_682226_1 1121403.AUCV01000016_gene4413 2.19e-24 94.4 2C06Z@1|root,3335S@2|Bacteria,1NI0C@1224|Proteobacteria,42X3F@68525|delta/epsilon subdivisions,2WT33@28221|Deltaproteobacteria,2MP40@213118|Desulfobacterales 28221|Deltaproteobacteria S Nif11 domain - - - - - - - - - - - - Nif11 k59_909706_1 886293.Sinac_7422 5.46e-166 478.0 COG3344@1|root,COG3344@2|Bacteria,2IZGP@203682|Planctomycetes 203682|Planctomycetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_808258_1 1341181.FLJC2902T_14840 1.92e-47 160.0 COG4152@1|root,COG4152@2|Bacteria,4NEJE@976|Bacteroidetes,1HXY0@117743|Flavobacteriia,2NSC2@237|Flavobacterium 976|Bacteroidetes S ABC transporter, ATP-binding protein natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_975077_1 443143.GM18_0785 3.85e-16 79.7 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42QU4@68525|delta/epsilon subdivisions,2WMRQ@28221|Deltaproteobacteria,43SHI@69541|Desulfuromonadales 28221|Deltaproteobacteria M Domain amino terminal to FKBP-type peptidyl-prolyl isomerase - - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_975974_1 485915.Dret_1447 2.82e-93 284.0 COG0436@1|root,COG0436@2|Bacteria,1MX43@1224|Proteobacteria,42Q5H@68525|delta/epsilon subdivisions,2WKW4@28221|Deltaproteobacteria,2M80H@213115|Desulfovibrionales 28221|Deltaproteobacteria E Aminotransferase, class I - - - - - - - - - - - - Aminotran_1_2 k59_23523_1 749222.Nitsa_0045 1.29e-206 587.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE k59_23523_2 2340.JV46_18860 1.09e-06 53.5 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J7Q2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Bacterial type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_59490_1 379066.GAU_2396 4.25e-57 188.0 COG1005@1|root,COG1005@2|Bacteria,1ZUSH@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_59490_2 713587.THITH_10355 1.94e-40 147.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,NADH-G_4Fe-4S_3 k59_161096_1 563040.Saut_0894 4.86e-97 291.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,42KZ6@68525|delta/epsilon subdivisions,2YMPZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S hmm pf04305 - - - - - - - - - - - - DUF455 k59_389323_1 283699.D172_2203 1.06e-66 214.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN2K@1236|Gammaproteobacteria,2PZXT@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K COG1609 Transcriptional regulators - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_321006_1 326297.Sama_1420 2.05e-30 121.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q9NW@267890|Shewanellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_321006_2 861299.J421_0337 0.000933 42.7 COG0841@1|root,COG0841@2|Bacteria,1ZTEK@142182|Gemmatimonadetes 142182|Gemmatimonadetes V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1009233_1 1313421.JHBV01000032_gene1631 1.64e-162 472.0 COG2304@1|root,COG2304@2|Bacteria,4NFX3@976|Bacteroidetes,1IP2T@117747|Sphingobacteriia 976|Bacteroidetes P von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - CarbopepD_reg_2,DUF3520,VWA,vWF_A k59_389324_1 469618.FVAG_00645 4.54e-152 438.0 COG1004@1|root,COG1004@2|Bacteria,379NW@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_780398_1 1157708.KB907463_gene707 4.82e-33 124.0 COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2VPNT@28216|Betaproteobacteria,4ABJK@80864|Comamonadaceae 28216|Betaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,PGAP1 k59_1041487_1 1121406.JAEX01000002_gene890 1.9e-86 265.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MR6@68525|delta/epsilon subdivisions,2WITP@28221|Deltaproteobacteria,2MAK6@213115|Desulfovibrionales 28221|Deltaproteobacteria S TIGRFAM TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_714854_2 652103.Rpdx1_2138 4.37e-22 95.5 COG1309@1|root,COG1309@2|Bacteria,1MY9K@1224|Proteobacteria,2U3PH@28211|Alphaproteobacteria,3JXKW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_419853_1 395019.Bmul_0674 1.11e-15 73.9 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2VQ1I@28216|Betaproteobacteria,1K2BA@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_419853_2 765911.Thivi_4149 5.97e-151 431.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1WVZH@135613|Chromatiales 135613|Chromatiales F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_419853_3 713587.THITH_05085 6.78e-56 177.0 COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,1SCFP@1236|Gammaproteobacteria,1WZCF@135613|Chromatiales 135613|Chromatiales S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_683109_1 1165841.SULAR_04673 8.06e-59 211.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions 1224|Proteobacteria D biosynthesis protein - - - ko:K16554,ko:K16692 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,Wzz k59_910723_1 439235.Dalk_3423 6.5e-76 241.0 COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria,2MHYD@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF3390) - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_419854_1 264203.ZMO0107 0.000489 46.6 COG0746@1|root,COG0746@2|Bacteria,1QWF1@1224|Proteobacteria,2TXF5@28211|Alphaproteobacteria,2KEHV@204457|Sphingomonadales 204457|Sphingomonadales H MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_419854_2 1265313.HRUBRA_01474 3.5e-99 300.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,1RS1U@1236|Gammaproteobacteria 1236|Gammaproteobacteria K acetyltransferase yghO GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - - k59_714858_1 1172190.M947_04210 2.59e-51 185.0 COG4783@1|root,COG4783@2|Bacteria,1QZ2M@1224|Proteobacteria,43CEP@68525|delta/epsilon subdivisions,2YTC5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S chaperone-mediated protein folding - - - - - - - - - - - - - k59_910733_1 1380394.JADL01000005_gene5530 6.7e-10 64.3 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2TS8U@28211|Alphaproteobacteria,2JPQ0@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_193251_1 572544.Ilyop_0012 6.38e-261 739.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,378F8@32066|Fusobacteria 32066|Fusobacteria J Phenylalanyl-tRNA synthetase beta pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_193251_2 572544.Ilyop_0011 4.72e-156 443.0 COG0016@1|root,COG0016@2|Bacteria,378EX@32066|Fusobacteria 32066|Fusobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_780421_1 1120950.KB892779_gene942 4.59e-37 134.0 COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4DNJ4@85009|Propionibacteriales 201174|Actinobacteria E ATPases associated with a variety of cellular activities - - 3.6.3.21 ko:K02028,ko:K02029 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_780421_2 1304865.JAGF01000001_gene3885 7.08e-09 56.6 COG0765@1|root,COG0765@2|Bacteria,2GM0I@201174|Actinobacteria 201174|Actinobacteria E amino acid ABC transporter - - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_161129_1 357804.Ping_2217 6.43e-16 71.6 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,2QIDF@267894|Psychromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_161129_2 1123399.AQVE01000025_gene1967 1.29e-50 165.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,460MP@72273|Thiotrichales 72273|Thiotrichales J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_1009256_1 1223410.KN050846_gene2325 7.03e-86 264.0 COG0772@1|root,COG0772@2|Bacteria,4NDZD@976|Bacteroidetes,1HXI4@117743|Flavobacteriia 976|Bacteroidetes D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1009256_2 997884.HMPREF1068_01982 0.00029 43.1 COG1864@1|root,COG1864@2|Bacteria,4NFYJ@976|Bacteroidetes,2FNBK@200643|Bacteroidia,4AMSR@815|Bacteroidaceae 976|Bacteroidetes F Psort location Extracellular, score nucA_1 - - ko:K01173 ko04210,map04210 - - - ko00000,ko00001,ko03029 - - - Endonuclease_NS k59_1009259_1 338966.Ppro_0375 9.92e-41 141.0 2C0BR@1|root,32Z3H@2|Bacteria,1RKTR@1224|Proteobacteria,43DNX@68525|delta/epsilon subdivisions,2X6PK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF4255) - - - - - - - - - - - - DUF4255 k59_683131_1 596151.DesfrDRAFT_0930 1.42e-50 184.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X7E0@28221|Deltaproteobacteria,2MHE4@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_321036_1 1565314.OA34_06400 2.16e-29 109.0 2EPCY@1|root,33GZK@2|Bacteria,1NIMP@1224|Proteobacteria,42VZ6@68525|delta/epsilon subdivisions,2YQ6H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_93784_1 768671.ThimaDRAFT_3618 1.29e-214 598.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales 135613|Chromatiales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_93784_2 1269813.ATUL01000045_gene1265 6.34e-27 102.0 COG1366@1|root,COG1366@2|Bacteria,1MZ5N@1224|Proteobacteria,1S9QR@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) - - - ko:K20978 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - STAS,STAS_2 k59_93784_3 1316927.ATKI01000048_gene203 3.76e-26 101.0 COG1366@1|root,COG1366@2|Bacteria,1MZ5N@1224|Proteobacteria,1S9QR@1236|Gammaproteobacteria,1YQRR@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T STAS domain rsbV - - ko:K20978 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - STAS_2 k59_93784_5 1123279.ATUS01000001_gene1468 2.74e-130 384.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,1J5DG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_93784_6 765914.ThisiDRAFT_0315 2.14e-77 238.0 COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,1S41X@1236|Gammaproteobacteria,1WVY2@135613|Chromatiales 135613|Chromatiales NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_93784_7 1049564.TevJSym_aa01040 5.44e-115 339.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria,1J5X9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006935,GO:0008022,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0008983,GO:0009605,GO:0009987,GO:0010340,GO:0016020,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0032991,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051998,GO:0071704,GO:0071944,GO:0098561,GO:0140096,GO:1901564 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_93784_8 1168067.JAGP01000001_gene740 1.16e-08 56.6 2ER53@1|root,33IQN@2|Bacteria,1QVWM@1224|Proteobacteria,1T2KX@1236|Gammaproteobacteria,4634N@72273|Thiotrichales 72273|Thiotrichales S STAS domain - - - - - - - - - - - - STAS_2 k59_93784_9 1385515.N791_14380 2.48e-45 153.0 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,1S26J@1236|Gammaproteobacteria,1X6CY@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis signal transduction protein cheW1 - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_93784_10 1049564.TevJSym_bh00210 4.4e-154 470.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1J4C5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_8 k59_93784_11 1415780.JPOG01000001_gene851 6.52e-34 125.0 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,1S26J@1236|Gammaproteobacteria,1X6CY@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis signal transduction protein cheW1 - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_93784_12 686340.Metal_1751 4.06e-250 716.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XDPM@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, phosphotransfer (Hpt) region - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_93784_13 1219375.CM002139_gene1926 2.05e-55 175.0 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,1S67R@1236|Gammaproteobacteria,1X6J2@135614|Xanthomonadales 135614|Xanthomonadales KT Fis family transcriptional regulator cheY1 - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_93784_14 631362.Thi970DRAFT_04263 2.44e-36 132.0 COG3023@1|root,COG3023@2|Bacteria,1N0IM@1224|Proteobacteria,1S959@1236|Gammaproteobacteria,1WZ3E@135613|Chromatiales 135613|Chromatiales V N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2 k59_93784_15 765911.Thivi_0235 6.7e-78 264.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1WW1M@135613|Chromatiales 135613|Chromatiales S ErfK YbiS YcfS YnhG family protein - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_93784_17 1121937.AUHJ01000026_gene36 3.02e-112 333.0 COG0582@1|root,COG0582@2|Bacteria,1MXUB@1224|Proteobacteria,1RPVR@1236|Gammaproteobacteria,46BJA@72275|Alteromonadaceae 1236|Gammaproteobacteria L Phage integrase, N-terminal - - - - - - - - - - - - Integrase_1,Phage_int_SAM_2 k59_93784_18 232346.JHQL01000004_gene1683 1.53e-07 51.6 2EE35@1|root,33E1B@2|Bacteria,1NKKN@1224|Proteobacteria,1STR1@1236|Gammaproteobacteria,1XQGA@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_649983_1 572544.Ilyop_0294 7.26e-35 132.0 COG5016@1|root,COG5016@2|Bacteria,378IQ@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score pycB - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - HMGL-like,PYC_OADA k59_225471_1 572544.Ilyop_0180 0.0 1097.0 COG0086@1|root,COG0086@2|Bacteria,378G7@32066|Fusobacteria 32066|Fusobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_552847_1 1095769.CAHF01000011_gene2568 6.84e-13 73.9 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS,PAS_3 k59_683132_1 1168034.FH5T_00790 8.2e-121 374.0 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_683132_2 1168034.FH5T_00795 6.72e-07 52.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,2FWS8@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_584789_1 709032.Sulku_2060 1.32e-39 133.0 COG0852@1|root,COG0852@2|Bacteria,1Q346@1224|Proteobacteria,42WRC@68525|delta/epsilon subdivisions,2YQIS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - - - - - - - - - - - Complex1_30kDa k59_584789_2 1249480.B649_09690 8.35e-110 317.0 COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2YMSW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NADH ubiquinone oxidoreductase, 20 Kd subunit - - - - - - - - - - - - Oxidored_q6 k59_584789_3 709032.Sulku_2062 7.8e-17 78.6 COG0650@1|root,COG0650@2|Bacteria,1QUK1@1224|Proteobacteria,42PHN@68525|delta/epsilon subdivisions 1224|Proteobacteria C PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - ko:K14087 - - - - ko00000 - - - NADHdh k59_746028_1 1268240.ATFI01000009_gene1952 8.22e-58 202.0 2DBE2@1|root,2Z8QB@2|Bacteria,4NK8H@976|Bacteroidetes,2FR3H@200643|Bacteroidia,4AVAR@815|Bacteroidaceae 976|Bacteroidetes - - - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_910756_1 1168034.FH5T_17615 4.53e-97 294.0 28H5M@1|root,2Z7I7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_780438_1 1380391.JIAS01000013_gene3781 5.7e-53 188.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,2JUYT@204441|Rhodospirillales 204441|Rhodospirillales S Alpha-2-Macroglobulin - - - - - - - - - - - - A2M,A2M_N,A2M_N_2 k59_617892_1 387093.SUN_1621 6.93e-61 201.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,42NTK@68525|delta/epsilon subdivisions,2YNFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_257165_2 469616.FMAG_01332 3.67e-71 227.0 COG1082@1|root,COG1082@2|Bacteria,37AGP@32066|Fusobacteria 32066|Fusobacteria G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_257165_3 305900.GV64_23840 5.92e-08 52.8 COG3717@1|root,COG3717@2|Bacteria,1MU9D@1224|Proteobacteria,1RPDB@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008697,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016860,GO:0016861,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042802,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046872,GO:0071704,GO:0072329,GO:1901575 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_649993_1 1123392.AQWL01000009_gene1115 8.46e-124 363.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VR2T@28216|Betaproteobacteria 28216|Betaproteobacteria H PUA-like domain sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PK,PUA_2 k59_1010006_1 1168034.FH5T_03600 2.61e-153 442.0 COG0488@1|root,COG0488@2|Bacteria,4NF6E@976|Bacteroidetes,2FNX4@200643|Bacteroidia 976|Bacteroidetes S ATPase components of ABC transporters with duplicated ATPase domains - - - - - - - - - - - - ABC_tran k59_521478_1 709032.Sulku_1505 9e-10 66.6 COG2199@1|root,COG3706@2|Bacteria,1R1K2@1224|Proteobacteria,42YWW@68525|delta/epsilon subdivisions,2YR1I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Double sensory domain of two-component sensor kinase - - - - - - - - - - - - GGDEF,dCache_3 k59_127521_1 1123073.KB899242_gene1352 6e-71 229.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,1RNV5@1236|Gammaproteobacteria,1X4BD@135614|Xanthomonadales 135614|Xanthomonadales I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_24382_1 1049564.TevJSym_ao00610 1.56e-95 293.0 COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1J4M1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S glutamate--cysteine ligase ybdK_1 - - - - - - - - - - - GCS2 k59_226369_1 1278307.KB907022_gene821 1.11e-52 172.0 COG0813@1|root,COG0813@2|Bacteria,1MUW6@1224|Proteobacteria,1RMMA@1236|Gammaproteobacteria,2QHIQ@267894|Psychromonadaceae 1236|Gammaproteobacteria F Phosphorylase superfamily deoD - 2.4.2.1 ko:K03784 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_226369_2 1408444.JHYC01000011_gene994 3.68e-05 46.2 COG1015@1|root,COG1015@2|Bacteria,1MVN8@1224|Proteobacteria,1RQ6W@1236|Gammaproteobacteria,1JCTU@118969|Legionellales 118969|Legionellales G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme k59_321845_1 387093.SUN_1922 2.2e-55 182.0 2ENEN@1|root,33G25@2|Bacteria,1NIJM@1224|Proteobacteria,42U7Y@68525|delta/epsilon subdivisions,2YPT3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_257951_2 1121935.AQXX01000100_gene1272 6.46e-79 246.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria,1XJCP@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126,SHOCT k59_60404_1 1121468.AUBR01000012_gene2601 1.79e-77 233.0 2F0YS@1|root,33U0E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_60404_2 880072.Desac_0499 1.78e-37 137.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales 28221|Deltaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_715654_1 1408473.JHXO01000017_gene2951 8.56e-70 225.0 2CESB@1|root,2Z8UZ@2|Bacteria,4NJSJ@976|Bacteroidetes,2FXQC@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - DUF481 k59_781298_1 1249627.D779_3974 5.3e-06 50.4 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1WX92@135613|Chromatiales 135613|Chromatiales D probably involved in intracellular septation - - - ko:K06190 - - - - ko00000 - - - IspA k59_781298_2 1182590.BN5_02037 6.53e-22 90.9 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1YDT7@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Belongs to the SUA5 family yciO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Sua5_yciO_yrdC k59_618650_1 1168034.FH5T_10560 1.59e-61 191.0 COG0792@1|root,COG0792@2|Bacteria,4NS7E@976|Bacteroidetes,2FSN9@200643|Bacteroidia 976|Bacteroidetes L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_162001_1 1218075.BAYA01000009_gene2925 5.01e-65 218.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,1K2QA@119060|Burkholderiaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_60414_1 290340.AAur_3400 1.17e-21 98.6 COG3266@1|root,COG3266@2|Bacteria 2|Bacteria GM domain, Protein pcm - 2.1.1.77,2.7.7.7 ko:K00573,ko:K02335,ko:K03980,ko:K20541,ko:K21397 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko01011,ko02000,ko03032,ko03400 2.A.66.4,3.A.1,4.D.3.1.6 - - - k59_323391_2 857087.Metme_2449 4.88e-88 262.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1XDP9@135618|Methylococcales 135618|Methylococcales I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1043873_2 1168034.FH5T_04810 1.92e-132 377.0 COG0221@1|root,COG0221@2|Bacteria,4NGBU@976|Bacteroidetes,2FRF9@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the hydrolysis of ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_620156_1 1168034.FH5T_19500 3.99e-49 177.0 COG1470@1|root,COG1470@2|Bacteria,4NFPN@976|Bacteroidetes,2FMUB@200643|Bacteroidia 976|Bacteroidetes S COG NOG25960 non supervised orthologous group - - - - - - - - - - - - CarbopepD_reg_2 k59_1043877_1 1035196.HMPREF9998_01870 7.18e-42 157.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,25QN0@186804|Peptostreptococcaceae 186801|Clostridia L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_227923_1 242619.PG_2215 1.81e-49 174.0 COG0836@1|root,COG0836@2|Bacteria,4NE1Y@976|Bacteroidetes,2FNHF@200643|Bacteroidia,22X4P@171551|Porphyromonadaceae 976|Bacteroidetes M mannose-1-phosphate guanylyltransferase manC - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_227923_2 572544.Ilyop_0813 5.45e-67 214.0 2AKF7@1|root,31B6Q@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_227923_3 153948.NAL212_1243 1.34e-25 107.0 2DDZV@1|root,32U2A@2|Bacteria,1MZU0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_61908_1 1049564.TevJSym_ag00460 2.07e-102 301.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1J6IW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G HAD-hyrolase-like gph GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756 HAD_2 k59_227929_1 1172190.M947_04155 1.14e-35 122.0 2AITQ@1|root,319AS@2|Bacteria,1Q26T@1224|Proteobacteria,42V2V@68525|delta/epsilon subdivisions,2YQFN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S putative NADH-ubiquinone oxidoreductase chain E nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADH-UOR_E k59_227929_2 1249480.B649_01165 4.5e-139 411.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2YM9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase - - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 k59_25852_1 1168034.FH5T_20035 2.55e-92 279.0 COG2502@1|root,COG2502@2|Bacteria,4NFZA@976|Bacteroidetes,2FMP0@200643|Bacteroidia 976|Bacteroidetes E aspartate--ammonia ligase asnA - 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 - R00483 RC00010 ko00000,ko00001,ko01000 - - - AsnA k59_978592_1 1218075.BAYA01000008_gene2764 1.8e-28 113.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VZEK@28216|Betaproteobacteria,1K56M@119060|Burkholderiaceae 28216|Betaproteobacteria J tRNA synthetases class I (C) catalytic domain - - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1e k59_847463_1 387093.SUN_1607 9.18e-42 145.0 COG0731@1|root,COG0731@2|Bacteria,1QG36@1224|Proteobacteria,42M82@68525|delta/epsilon subdivisions,2YN42@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM k59_391770_2 945713.IALB_0545 4.08e-11 62.8 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion - - - - - - - - - - - - Band_7 k59_227930_1 477228.YO5_02633 1.59e-25 103.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1Z1TM@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_227930_2 243233.MCA1746 5.95e-19 81.6 COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1XFS7@135618|Methylococcales 135618|Methylococcales K Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters - - - ko:K03557 ko05111,map05111 - - - ko00000,ko00001,ko03000,ko03036,ko03400 - - - HTH_8 k59_358765_1 1166948.JPZL01000002_gene1795 1.16e-48 176.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,1XKSS@135619|Oceanospirillales 135619|Oceanospirillales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_129411_1 1249480.B649_08005 6.28e-126 361.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2YN03@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1011633_1 556269.ACDQ01000017_gene934 1.01e-26 108.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,4728K@75682|Oxalobacteraceae 28216|Betaproteobacteria P Ferrous iron transport protein B C terminus feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_1011633_2 556269.ACDQ01000017_gene935 1.99e-13 67.8 COG1918@1|root,COG1918@2|Bacteria 2|Bacteria P iron ion homeostasis feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_129413_1 1033802.SSPSH_000458 1.15e-40 154.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_323435_2 1196028.ALEF01000025_gene1733 8.1e-25 98.6 2AFC0@1|root,315BI@2|Bacteria,1V6Y8@1239|Firmicutes,4HJ3Q@91061|Bacilli,4C6TG@84406|Virgibacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_422187_1 1121013.P873_05470 9.06e-55 188.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1X3E2@135614|Xanthomonadales 135614|Xanthomonadales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_812032_1 1121937.AUHJ01000005_gene2319 1.05e-51 169.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,466DN@72275|Alteromonadaceae 1236|Gammaproteobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_812032_2 351348.Maqu_1612 1.86e-34 120.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,4683K@72275|Alteromonadaceae 1236|Gammaproteobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363 - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_685940_1 754477.Q7C_1290 4.25e-06 49.3 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,45ZWJ@72273|Thiotrichales 72273|Thiotrichales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_323446_2 1415780.JPOG01000001_gene2740 1.4e-53 187.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1XCEY@135614|Xanthomonadales 135614|Xanthomonadales C Molydopterin dinucleotide binding domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_812036_1 1005395.CSV86_14169 2.15e-05 45.4 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1YW9F@136845|Pseudomonas putida group 1236|Gammaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2564,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390 PdxJ k59_812036_2 768671.ThimaDRAFT_4258 1.64e-50 171.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1WY02@135613|Chromatiales 135613|Chromatiales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_422199_1 588581.Cpap_0079 9.17e-78 265.0 COG2227@1|root,COG2230@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG2230@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia 186801|Clostridia Q Beta-ketoacyl synthase - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_487265_1 1168034.FH5T_12425 3.85e-47 164.0 COG1215@1|root,COG1215@2|Bacteria,4NESG@976|Bacteroidetes,2FN9E@200643|Bacteroidia 976|Bacteroidetes M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_391797_1 335543.Sfum_2689 7.66e-102 320.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MQ5F@213462|Syntrophobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1011645_1 1174528.JH992890_gene527 5.13e-79 250.0 COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_422200_1 479434.Sthe_0681 3.39e-20 91.7 COG2186@1|root,COG2186@2|Bacteria,2GBBV@200795|Chloroflexi,27YQ1@189775|Thermomicrobia 189775|Thermomicrobia K FCD - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR k59_748264_2 933262.AXAM01000010_gene1402 3.52e-46 159.0 COG0484@1|root,COG0705@1|root,COG0484@2|Bacteria,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2MI6P@213118|Desulfobacterales 28221|Deltaproteobacteria O Rhomboid family - - - ko:K07059 - - - - ko00000 - - - DnaJ_C,Rhomboid k59_978617_1 870187.Thini_4460 5.42e-38 135.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,460E1@72273|Thiotrichales 72273|Thiotrichales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_978617_2 1120953.AUBH01000005_gene2198 1.22e-64 204.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,466EI@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily yrdA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840 - - - - - - - - - - Hexapep k59_259491_1 749222.Nitsa_1912 1.34e-40 150.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2YMVT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FP Guanosine pentaphosphate phosphohydrolase gppA - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_422211_1 1211817.CCAT010000084_gene1855 1.65e-06 51.6 COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_9 k59_422211_2 381666.H16_A0680 2.23e-18 84.0 COG3613@1|root,COG3613@2|Bacteria,1N0AK@1224|Proteobacteria,2VRQT@28216|Betaproteobacteria,1K7XQ@119060|Burkholderiaceae 28216|Betaproteobacteria F Nucleoside 2-deoxyribosyltransferase - - 2.4.2.6 ko:K08728 ko00240,map00240 - R02806 RC00063 ko00000,ko00001,ko01000 - - - Nuc_deoxyrib_tr k59_749370_1 1123371.ATXH01000009_gene1096 5.98e-68 232.0 28N6D@1|root,2ZBB9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_979714_1 387093.SUN_1873 4.97e-55 179.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2YPMC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_423312_1 1168034.FH5T_13810 1.53e-66 214.0 COG0498@1|root,COG0498@2|Bacteria,4NEAA@976|Bacteroidetes,2FMPH@200643|Bacteroidia 976|Bacteroidetes E Threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_synth_N k59_423312_2 1168034.FH5T_13805 2.82e-62 202.0 COG3635@1|root,COG3635@2|Bacteria,4NH0F@976|Bacteroidetes,2FMC7@200643|Bacteroidia 976|Bacteroidetes G homoserine kinase - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_914060_1 1131462.DCF50_p933 1.61e-43 156.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,2610M@186807|Peptococcaceae 186801|Clostridia C iron hydrogenase, small subunit - - 1.12.1.3,1.6.5.3 ko:K00336,ko:K18332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_9,NADH-G_4Fe-4S_3 k59_291880_1 1121396.KB892990_gene4509 5.49e-10 60.1 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,42PXB@68525|delta/epsilon subdivisions,2WJKN@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sh3 type 3 domain protein - - - - - - - - - - - - - k59_291880_2 1122179.KB890463_gene2117 6.03e-08 57.4 COG1309@1|root,COG1309@2|Bacteria,4NIBT@976|Bacteroidetes,1IS9H@117747|Sphingobacteriia 976|Bacteroidetes K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_718409_1 1208323.B30_03967 4.21e-19 86.3 COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2TU43@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria yedI - - ko:K09781 - - - - ko00000 - - - DUF808 k59_718409_2 1353537.TP2_12985 9.9e-72 219.0 COG2214@1|root,COG2214@2|Bacteria,1MXTG@1224|Proteobacteria,2TRZH@28211|Alphaproteobacteria,2XMSE@285107|Thioclava 28211|Alphaproteobacteria O molecular chaperone - - - - - - - - - - - - DnaJ k59_260604_1 933262.AXAM01000034_gene1559 4.64e-43 155.0 COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales 28221|Deltaproteobacteria T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - - - - - - - - - - - k59_130363_1 1328313.DS2_11448 2.47e-13 70.9 COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,466VV@72275|Alteromonadaceae 1236|Gammaproteobacteria C glycerophosphoryl diester phosphodiesterase ugpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_130363_2 1123399.AQVE01000006_gene3442 2.06e-21 88.2 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria,4619K@72273|Thiotrichales 72273|Thiotrichales S PFAM Sulphur oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_130363_3 90813.JQMT01000001_gene1383 9.45e-10 57.4 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S4ZT@1236|Gammaproteobacteria,461A3@72273|Thiotrichales 72273|Thiotrichales S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY,TAT_signal k59_26782_1 749222.Nitsa_0820 5.78e-34 133.0 COG2172@1|root,COG3153@1|root,COG2172@2|Bacteria,COG3153@2|Bacteria,1QXS5@1224|Proteobacteria,43CKS@68525|delta/epsilon subdivisions,2YNB9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase-like ATPase domain - - - - - - - - - - - - Acetyltransf_1,HATPase_c_2 k59_718423_1 1395571.TMS3_0115630 1.74e-101 309.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria 1236|Gammaproteobacteria E alanine symporter dagA - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_260623_1 572544.Ilyop_1352 3.89e-99 295.0 COG0483@1|root,COG0483@2|Bacteria 2|Bacteria G inositol monophosphate 1-phosphatase activity - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_260623_2 509191.AEDB02000073_gene1998 2.05e-240 686.0 COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,3WG9Y@541000|Ruminococcaceae 186801|Clostridia P Psort location CytoplasmicMembrane, score cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase k59_979746_1 1049564.TevJSym_ad00530 6.67e-92 273.0 COG0377@1|root,COG0377@2|Bacteria,1Q273@1224|Proteobacteria,1S0ZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM NADH Ubiquinone - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_324806_1 527002.yaldo0001_37630 6.92e-90 292.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,41E53@629|Yersinia 1236|Gammaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_749441_1 909663.KI867150_gene87 9.43e-28 113.0 COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions,2WNJZ@28221|Deltaproteobacteria,2MR4S@213462|Syntrophobacterales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE4,HAMP,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9 k59_749441_2 999541.bgla_2g14040 1.52e-14 72.4 COG2197@1|root,COG2197@2|Bacteria,1RENN@1224|Proteobacteria,2VR4J@28216|Betaproteobacteria,1K03Q@119060|Burkholderiaceae 28216|Betaproteobacteria K regulator - - - - - - - - - - - - GerE,Response_reg k59_653323_1 580332.Slit_0783 3.86e-25 96.7 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,44W0K@713636|Nitrosomonadales 28216|Betaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_653323_2 765912.Thimo_2843 1.49e-82 248.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,1WX2D@135613|Chromatiales 135613|Chromatiales J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_653323_3 948565.AFFP02000030_gene1192 9.47e-20 80.9 COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,1Y992@135625|Pasteurellales 135625|Pasteurellales J Ribosomal protein L30 rpmD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_653323_4 998674.ATTE01000001_gene4300 9.59e-45 148.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,460T4@72273|Thiotrichales 72273|Thiotrichales J binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_260639_1 929558.SMGD1_2746 1.36e-77 241.0 COG2301@1|root,COG2301@2|Bacteria,1NUDQ@1224|Proteobacteria,42QUW@68525|delta/epsilon subdivisions,2YNZV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the HpcH HpaI aldolase family citE - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_324815_1 1120999.JONM01000008_gene1992 7.46e-15 76.3 COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,2VRKF@28216|Betaproteobacteria,2KRPU@206351|Neisseriales 206351|Neisseriales S Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - CbiM k59_1012517_1 713587.THITH_03095 2.66e-62 208.0 28MDZ@1|root,2ZARR@2|Bacteria,1R681@1224|Proteobacteria,1SJTA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_423356_1 554065.XP_005850091.1 1.31e-10 61.2 2D09G@1|root,2S4T9@2759|Eukaryota,380ZY@33090|Viridiplantae 33090|Viridiplantae - - - - - - - - - - - - - - - k59_749457_1 631362.Thi970DRAFT_01435 3.51e-66 206.0 COG4636@1|root,COG4636@2|Bacteria,1RCFH@1224|Proteobacteria,1S3NE@1236|Gammaproteobacteria,1X0P4@135613|Chromatiales 135613|Chromatiales S Putative restriction endonuclease - - - - - - - - - - - - Uma2 k59_324818_1 387092.NIS_0542 5.5e-18 83.2 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2YM9G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_324818_2 1172190.M947_11555 1.21e-48 164.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2YMHT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D rod shape-determining protein mreB mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_813291_1 243159.AFE_2393 5.66e-06 47.0 COG3415@1|root,COG3415@2|Bacteria,1RFNA@1224|Proteobacteria,1S5WD@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2963 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_23,HTH_Tnp_1 k59_813291_2 448385.sce6613 6.19e-141 409.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,42MUE@68525|delta/epsilon subdivisions,2WJFZ@28221|Deltaproteobacteria,2YWD1@29|Myxococcales 28221|Deltaproteobacteria L High confidence in function and specificity - - - - - - - - - - - - HTH_23,HTH_32,rve,rve_3 k59_425365_1 469618.FVAG_02963 3.04e-88 273.0 COG0285@1|root,COG0285@2|Bacteria,378AP@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_425365_2 572544.Ilyop_0837 9.5e-119 344.0 COG0775@1|root,COG0775@2|Bacteria,3784Q@32066|Fusobacteria 32066|Fusobacteria E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively mtnN - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_131157_2 1121456.ATVA01000015_gene2309 7.68e-29 105.0 2C396@1|root,3304Q@2|Bacteria,1NAD5@1224|Proteobacteria,42W3F@68525|delta/epsilon subdivisions,2WRWB@28221|Deltaproteobacteria,2MCQZ@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_915740_1 794903.OPIT5_30560 3.52e-95 309.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,46U8Q@74201|Verrucomicrobia,3K77Q@414999|Opitutae 414999|Opitutae F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_719632_1 983328.AFGH01000033_gene809 5.64e-21 94.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2YNF8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains flgR - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_719632_2 1355374.JARU01000013_gene54 1.29e-13 69.7 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2YMIV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_784934_1 1249480.B649_00070 2.7e-124 358.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2YMQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_163928_1 469616.FMAG_02176 1.08e-60 225.0 COG1452@1|root,COG1452@2|Bacteria,37983@32066|Fusobacteria 32066|Fusobacteria M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - k59_261976_1 1158318.ATXC01000002_gene1547 3.79e-26 111.0 COG4147@1|root,COG4147@2|Bacteria,2G4IH@200783|Aquificae 200783|Aquificae S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_229323_1 1304885.AUEY01000018_gene1098 6.45e-51 176.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2MHMC@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_588907_1 929558.SMGD1_1183 6.69e-80 253.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2YMSH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c oxidase accessory protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_458148_1 1488328.JMCL01000014_gene362 2.78e-32 122.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria 1236|Gammaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_883094_1 572544.Ilyop_1381 3.44e-05 45.1 COG0496@1|root,COG0496@2|Bacteria,37BZU@32066|Fusobacteria 32066|Fusobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_883094_2 469616.FMAG_00126 1.47e-106 315.0 COG1692@1|root,COG1692@2|Bacteria,378NB@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - ko:K09769 - - - - ko00000 - - - YmdB k59_458151_1 1517416.IDAT_03570 4.59e-82 269.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2QEY1@267893|Idiomarinaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_915757_1 1331060.RLDS_11435 1.24e-81 260.0 COG4938@1|root,COG4938@2|Bacteria,1NEEG@1224|Proteobacteria,2UAZA@28211|Alphaproteobacteria,2KBCU@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF3696) - - - - - - - - - - - - AAA_15,DUF3696 k59_163937_1 1121481.AUAS01000004_gene1302 1.18e-48 175.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,47QEI@768503|Cytophagia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - ANAPC3,Guanylate_cyc,HTH_18,TPR_8 k59_392773_1 1298867.AUES01000051_gene4506 2.5e-70 234.0 COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria,3K33G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Peptidase, M50 family - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3,PqqD k59_360085_1 1168034.FH5T_11750 6.09e-256 713.0 COG0173@1|root,COG0173@2|Bacteria,4NECY@976|Bacteroidetes,2FMCA@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_360085_2 1168034.FH5T_11745 7.84e-91 267.0 COG0590@1|root,COG0590@2|Bacteria,4NNJ2@976|Bacteroidetes,2FSMJ@200643|Bacteroidia 976|Bacteroidetes FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k59_425386_1 595537.Varpa_4005 3.05e-59 198.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria,4AAZA@80864|Comamonadaceae 28216|Betaproteobacteria V secretion protein HlyD family emrA - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23 k59_686951_1 1537917.JU82_10455 9.7e-37 128.0 COG1433@1|root,COG1433@2|Bacteria,1N05Z@1224|Proteobacteria,42VFK@68525|delta/epsilon subdivisions,2YQG3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Dinitrogenase iron-molybdenum cofactor biosynthesis protein - - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_686951_2 944547.ABLL_0008 6.07e-68 207.0 COG1145@1|root,COG1145@2|Bacteria,1QZ2K@1224|Proteobacteria,42SFI@68525|delta/epsilon subdivisions,2YPQC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7 k59_588923_1 345073.VC395_1641 2.18e-13 71.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XTA5@135623|Vibrionales 135623|Vibrionales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_588923_2 62928.azo3490 4.13e-23 97.4 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,2VQMC@28216|Betaproteobacteria,2KWA2@206389|Rhodocyclales 206389|Rhodocyclales P Helix-turn-helix domain - - - - - - - - - - - - HTH_17,PBP_like k59_523498_1 321332.CYB_0235 1.8e-89 268.0 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1GYT4@1129|Synechococcus 1117|Cyanobacteria C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_1013828_1 644282.Deba_0035 3.09e-32 125.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJKZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1013828_2 1049564.TevJSym_aa01830 5.38e-19 86.7 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SNU0@1236|Gammaproteobacteria 1236|Gammaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_359_1 195250.CM001776_gene3991 3.93e-47 169.0 COG2217@1|root,COG2217@2|Bacteria,1G05S@1117|Cyanobacteria,1GZRH@1129|Synechococcus 1117|Cyanobacteria P P-type ATPase copA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_131586_1 1037409.BJ6T_47450 6.48e-06 46.6 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2TR5M@28211|Alphaproteobacteria,3JV9B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_131586_2 388401.RB2150_09129 2.01e-99 298.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,3ZGWS@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria C Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_671_1 1537917.JU82_03530 1.09e-198 562.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2YN13@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_671_3 1249480.B649_08920 1.46e-26 104.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2YMSY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Co-chaperone-curved DNA binding protein A cbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_981477_3 765913.ThidrDRAFT_2381 4.17e-71 233.0 COG3203@1|root,COG3203@2|Bacteria,1RH1J@1224|Proteobacteria,1S06S@1236|Gammaproteobacteria,1WWT7@135613|Chromatiales 135613|Chromatiales M PFAM porin Gram-negative type - - - - - - - - - - - - Porin_4 k59_589362_1 1105367.CG50_16105 1.93e-87 277.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_360569_2 713587.THITH_13850 2.59e-27 103.0 COG0662@1|root,COG0662@2|Bacteria,1QUHG@1224|Proteobacteria,1T1Z6@1236|Gammaproteobacteria,1WZ1B@135613|Chromatiales 135613|Chromatiales G PFAM Cupin 2, conserved barrel - - - ko:K11312 - - - - ko00000 - - - Cupin_2 k59_720068_1 1121403.AUCV01000019_gene3261 1.64e-56 176.0 COG0831@1|root,COG0831@2|Bacteria,1RGXE@1224|Proteobacteria,42QQW@68525|delta/epsilon subdivisions,2WPBR@28221|Deltaproteobacteria,2MNPS@213118|Desulfobacterales 28221|Deltaproteobacteria E Urease, gamma subunit ureA - 3.5.1.5 ko:K01430,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_beta,Urease_gamma k59_720068_2 595494.Tola_1620 1.86e-49 159.0 COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,1S8UP@1236|Gammaproteobacteria,1Y5UY@135624|Aeromonadales 135624|Aeromonadales E Belongs to the urease beta subunit family ureB - 3.5.1.5 ko:K01429 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_beta k59_687401_1 387092.NIS_1384 5.13e-59 197.0 COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2YNE2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_425787_1 1172190.M947_00070 3.28e-23 96.7 COG2836@1|root,COG2836@2|Bacteria,1QZ1V@1224|Proteobacteria,430HB@68525|delta/epsilon subdivisions,2YRZU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Cytochrome C biogenesis protein transmembrane region - - - - - - - - - - - - DsbD_2 k59_850821_2 246195.DNO_0173 4.23e-220 637.0 COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,1RXXN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DEAD DEAH box helicase - - - - - - - - - - - - DEAD,Helicase_C k59_393236_1 572544.Ilyop_1757 5.09e-126 369.0 COG0162@1|root,COG0162@2|Bacteria,378M9@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_197001_1 1392502.JNIO01000008_gene2979 3.82e-18 83.6 COG1879@1|root,COG1879@2|Bacteria,1TSBH@1239|Firmicutes 1239|Firmicutes G Periplasmic binding protein LacI transcriptional regulator - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_197001_2 765913.ThidrDRAFT_1929 9.04e-115 333.0 COG3897@1|root,COG3897@2|Bacteria,1MUWA@1224|Proteobacteria,1RRAF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Lysine methyltransferase - - - - - - - - - - - - Methyltransf_16 k59_360576_1 713586.KB900536_gene1569 5.99e-76 237.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria,1WWYR@135613|Chromatiales 135613|Chromatiales S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_654775_1 96561.Dole_2243 7.49e-46 157.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MHV8@213118|Desulfobacterales 28221|Deltaproteobacteria H aminotransferase class V - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_948879_1 1382306.JNIM01000001_gene2905 9.9e-42 151.0 COG2225@1|root,COG2225@2|Bacteria,2G63R@200795|Chloroflexi 200795|Chloroflexi H Belongs to the malate synthase family aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_948879_2 1504672.669783421 1.26e-77 243.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,4AA00@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM isocitrate lyase and phosphorylmutase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_491165_1 1410653.JHVC01000008_gene2996 1.07e-53 178.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,36DTB@31979|Clostridiaceae 186801|Clostridia F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_66167_1 1196324.A374_16013 1.71e-15 77.0 COG0745@1|root,COG0745@2|Bacteria,1TQ0D@1239|Firmicutes,4HDH2@91061|Bacilli 91061|Bacilli T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain resD1 - - ko:K20488 ko02020,ko02024,map02020,map02024 M00816 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_948881_1 563040.Saut_1189 6.87e-21 90.5 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2YNC5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_654785_1 1094980.Mpsy_1207 3.38e-22 95.5 COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,2N9QC@224756|Methanomicrobia 224756|Methanomicrobia L COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins - - - ko:K07466 ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460 M00288 - - ko00000,ko00001,ko00002,ko03000,ko03032,ko03400 - - - - k59_654785_2 797114.C475_12260 4.58e-19 87.8 COG3390@1|root,arCOG02257@2157|Archaea,2Y7XR@28890|Euryarchaeota,240ZD@183963|Halobacteria 183963|Halobacteria S protein conserved in archaea - - - ko:K09746 - - - - ko00000 - - - - k59_850841_1 686340.Metal_1019 6.03e-41 142.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1XDXU@135618|Methylococcales 135618|Methylococcales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_850841_2 697282.Mettu_2578 3.66e-13 63.9 COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,1XFW4@135618|Methylococcales 135618|Methylococcales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes - - - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - - CcmD k59_131619_1 1121405.dsmv_3234 1.93e-76 247.0 COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MHP4@213118|Desulfobacterales 28221|Deltaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_752775_1 572480.Arnit_0696 1.12e-05 47.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2YMV8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10 ko:K00795 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364 R01658,R02003 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_393249_1 387093.SUN_2203 2.5e-205 576.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2YMDF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_393249_2 1449345.JHWC01000005_gene1072 3.75e-26 103.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2YNW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_295106_2 1313304.CALK_1038 6.68e-29 106.0 COG0776@1|root,COG0776@2|Bacteria 2|Bacteria L regulation of translation hup_1 - - ko:K03530,ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_654794_1 96561.Dole_3159 1.92e-107 322.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2MHP1@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_589387_1 713586.KB900536_gene1841 7.83e-50 179.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_981505_1 749222.Nitsa_0641 7.72e-45 157.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2YMDM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H dihydropteroate synthase folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_425818_1 1319815.HMPREF0202_00144 9.73e-06 44.7 COG3952@1|root,COG3952@2|Bacteria,37AN1@32066|Fusobacteria 32066|Fusobacteria S Lipid A Biosynthesis N-terminal domain - - - - - - - - - - - - LAB_N k59_752780_1 1123392.AQWL01000001_gene1321 3.17e-30 110.0 COG0464@1|root,COG0464@2|Bacteria,1RIMZ@1224|Proteobacteria 1224|Proteobacteria O growth - - - - - - - - - - - - AAA k59_752780_2 1123392.AQWL01000001_gene1322 8.74e-46 147.0 COG3311@1|root,COG3311@2|Bacteria,1N779@1224|Proteobacteria,2VW5C@28216|Betaproteobacteria 28216|Betaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_17 k59_752780_3 643562.Daes_1650 2.26e-49 160.0 COG2105@1|root,COG2105@2|Bacteria,1R92V@1224|Proteobacteria,42QI0@68525|delta/epsilon subdivisions,2WKGE@28221|Deltaproteobacteria,2MAXV@213115|Desulfovibrionales 28221|Deltaproteobacteria S Gamma-glutamyl cyclotransferase, AIG2-like - - - - - - - - - - - - GGACT k59_818115_1 1168034.FH5T_17500 2.31e-37 139.0 COG3422@1|root,COG3422@2|Bacteria,4NHE4@976|Bacteroidetes,2G18X@200643|Bacteroidia 976|Bacteroidetes S double-strand break repair - - - - - - - - - - - - - k59_818115_2 1168034.FH5T_17495 2.84e-51 183.0 COG3299@1|root,COG3299@2|Bacteria,4NF69@976|Bacteroidetes,2FN8K@200643|Bacteroidia 976|Bacteroidetes S homolog of phage Mu protein gp47 - - - - - - - - - - - - Baseplate_J k59_164440_1 331678.Cphamn1_1670 2.11e-119 348.0 COG1397@1|root,COG1397@2|Bacteria 2|Bacteria O ADP-ribosylglycohydrolase draG - - - - - - - - - - - ADP_ribosyl_GH,Inositol_P k59_729836_1 1223410.KN050846_gene1529 5.49e-49 164.0 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1HYE4@117743|Flavobacteriia 976|Bacteroidetes T Universal stress protein uspA - - - - - - - - - - - Usp k59_240329_1 1191523.MROS_0889 2.15e-26 105.0 COG0546@1|root,COG0546@2|Bacteria 2|Bacteria S glycolate biosynthetic process cbbZp - 1.17.99.6,3.1.3.18 ko:K01091,ko:K18979 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000,ko03016 - - - HAD,HAD_2 k59_42811_1 313603.FB2170_07959 8.56e-35 122.0 COG0377@1|root,COG0377@2|Bacteria,4NFKT@976|Bacteroidetes,1I0R8@117743|Flavobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_42811_2 313603.FB2170_07964 8.46e-65 199.0 COG0838@1|root,COG0838@2|Bacteria,4NQET@976|Bacteroidetes,1IJ1X@117743|Flavobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_666232_1 1117315.AHCA01000002_gene3493 1.02e-08 55.8 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,2PZWV@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - iPC815.YPO1056 Acetyltransf_11,Hexapep k59_666232_2 1121013.P873_09715 3.7e-47 163.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1X349@135614|Xanthomonadales 135614|Xanthomonadales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_469383_2 1165841.SULAR_08060 1.89e-60 192.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,42V1Y@68525|delta/epsilon subdivisions,2YQ5Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Metal-dependent hydrolase - - - ko:K07043 - - - - ko00000 - - - DUF45,WLM k59_1024528_1 754476.Q7A_2991 2.88e-103 305.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,4600Q@72273|Thiotrichales 72273|Thiotrichales O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_600542_2 102232.GLO73106DRAFT_00031370 1.06e-64 199.0 COG1917@1|root,COG1917@2|Bacteria,1G7K6@1117|Cyanobacteria 1117|Cyanobacteria S ChrR Cupin-like domain - - - - - - - - - - - - Cupin_7 k59_143580_1 1236542.BALM01000005_gene2607 1.83e-25 108.0 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,2Q9BP@267890|Shewanellaceae 1236|Gammaproteobacteria T PFAM UspA domain protein uspE GO:0000302,GO:0001539,GO:0006928,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0034599,GO:0034614,GO:0034644,GO:0035690,GO:0040011,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071478,GO:0071482,GO:0071973,GO:0097237,GO:0097588,GO:0104004,GO:1901700,GO:1901701 - ko:K14055 - - - - ko00000 - - - Usp k59_7431_1 709991.Odosp_0033 2.47e-89 279.0 COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,2FNXT@200643|Bacteroidia,22X3P@171551|Porphyromonadaceae 976|Bacteroidetes S Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_698048_1 1249480.B649_11780 1.3e-127 384.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2YN94@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_861068_2 572544.Ilyop_1359 1.65e-52 168.0 COG0640@1|root,COG0640@2|Bacteria,37A93@32066|Fusobacteria 32066|Fusobacteria K Psort location Cytoplasmic, score 8.96 - - - ko:K21903 - - - - ko00000,ko03000 - - - HTH_5 k59_403589_1 96561.Dole_0203 1.36e-81 257.0 COG1960@1|root,COG1960@2|Bacteria,1R59X@1224|Proteobacteria,42P22@68525|delta/epsilon subdivisions,2WKQN@28221|Deltaproteobacteria,2MJCR@213118|Desulfobacterales 1224|Proteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_403589_2 96561.Dole_1472 2.55e-61 199.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42QX5@68525|delta/epsilon subdivisions,2WJVI@28221|Deltaproteobacteria,2MJ7U@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the thiolase family bbsB - - ko:K07550 ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220 M00418 R05587 RC00004,RC01428,RC02904 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_271896_1 751994.AGIG01000008_gene1128 5.42e-40 150.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_2673 ACT_4,HD_4,RelA_SpoT,TGS k59_371597_1 1443122.Z958_08380 1.95e-92 284.0 COG1301@1|root,COG1301@2|Bacteria,1TP4N@1239|Firmicutes,2494N@186801|Clostridia,36EQH@31979|Clostridiaceae 186801|Clostridia C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_371597_2 1123274.KB899410_gene3507 9.17e-47 172.0 COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,2J6QT@203691|Spirochaetes 203691|Spirochaetes EGT Amino acid permease - - - - - - - - - - - - AA_permease,PTS_EIIA_2 k59_894180_1 1168034.FH5T_05405 2.74e-68 216.0 COG0252@1|root,COG0252@2|Bacteria,4NE2Z@976|Bacteroidetes,2FM3E@200643|Bacteroidia 976|Bacteroidetes EJ L-asparaginase, type I ansA - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_503078_1 999419.HMPREF1077_00435 4.63e-36 124.0 COG1846@1|root,COG1846@2|Bacteria,4PKFS@976|Bacteroidetes,2FTYE@200643|Bacteroidia,22YI4@171551|Porphyromonadaceae 976|Bacteroidetes K Winged helix DNA-binding domain marR - - - - - - - - - - - HTH_34 k59_894181_2 243231.GSU0068 6.62e-55 177.0 2EE9W@1|root,3384B@2|Bacteria,1NCE1@1224|Proteobacteria,42VUH@68525|delta/epsilon subdivisions,2WSA1@28221|Deltaproteobacteria,43V30@69541|Desulfuromonadales 28221|Deltaproteobacteria C Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - - - - - - - - - - Cytochrom_c3_2 k59_793640_1 1049564.TevJSym_am00060 2.96e-54 184.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1J4KE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_271898_1 1537917.JU82_07845 5.11e-123 380.0 COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2YMXW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cytochrome c biogenesis protein ccsBA - - - - - - - - - - - Cytochrom_C_asm,ResB k59_861077_2 1488328.JMCL01000055_gene3279 1.22e-68 223.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1RRMI@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_240340_1 1319815.HMPREF0202_00126 1.54e-13 70.5 COG3833@1|root,COG3833@2|Bacteria,37C67@32066|Fusobacteria 32066|Fusobacteria G Binding-protein-dependent transport system inner membrane component - - - ko:K15772 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 k59_829342_2 479431.Namu_5171 3.44e-99 303.0 COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4ERRJ@85013|Frankiales 201174|Actinobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_861643_1 1460634.JCM19037_4689 2.07e-21 92.4 COG1280@1|root,COG1280@2|Bacteria,1V4T5@1239|Firmicutes,4HHK9@91061|Bacilli 91061|Bacilli E Lysine transporter LysE - - - - - - - - - - - - LysE k59_861643_3 1391647.AVSV01000007_gene146 1.65e-18 85.1 COG4565@1|root,COG4565@2|Bacteria,1V3PK@1239|Firmicutes,25B6C@186801|Clostridia,36WH6@31979|Clostridiaceae 186801|Clostridia KT cheY-homologous receiver domain - - - ko:K11615 ko02020,map02020 M00490 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg k59_861643_4 469618.FVAG_00037 1.42e-29 111.0 29IC7@1|root,3059E@2|Bacteria,37AAR@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_861643_5 572544.Ilyop_0031 6.56e-190 540.0 COG2610@1|root,COG2610@2|Bacteria,379II@32066|Fusobacteria 32066|Fusobacteria EG GntP family permease - - - ko:K03299 - - - - ko00000,ko02000 2.A.8 - - GntP_permease k59_861643_6 572544.Ilyop_0476 3.46e-151 436.0 COG1929@1|root,COG1929@2|Bacteria,379HN@32066|Fusobacteria 32066|Fusobacteria G Belongs to the glycerate kinase type-1 family - - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase k59_829343_1 298655.KI912266_gene4525 1.1e-30 123.0 28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria,4EU62@85013|Frankiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_793985_1 1168034.FH5T_18270 2e-89 275.0 COG0362@1|root,COG0362@2|Bacteria,4NG05@976|Bacteroidetes,2FMFW@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_601177_1 1123256.KB907926_gene1020 1.16e-89 278.0 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1X5U1@135614|Xanthomonadales 135614|Xanthomonadales EGP Acetyl-coenzyme A transporter 1 - - - - - - - - - - - - MFS_1 k59_928211_1 1168034.FH5T_06780 3.63e-78 256.0 COG0058@1|root,COG0058@2|Bacteria,4NGR1@976|Bacteroidetes,2FNN5@200643|Bacteroidia 976|Bacteroidetes G alpha-glucan phosphorylase glgP - 2.4.1.1,2.4.1.11,2.4.1.8 ko:K00688,ko:K00691,ko:K16153 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R00292,R01555,R02111 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003 - GH65,GT3,GT35 - DUF3417,Glycogen_syn,Phosphorylase k59_305506_1 886379.AEWI01000013_gene2151 6.53e-156 463.0 COG0542@1|root,COG0542@2|Bacteria,4NE1J@976|Bacteroidetes,2FNNW@200643|Bacteroidia,3XJJ6@558415|Marinilabiliaceae 976|Bacteroidetes O AAA ATPase domain clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_601182_1 991905.SL003B_0079 5.83e-20 88.2 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,4BPR9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria D PFAM CobQ CobB MinD ParA nucleotide binding domain parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_503724_1 1286632.P278_09360 1.27e-56 199.0 COG0526@1|root,COG0526@2|Bacteria,4NKFI@976|Bacteroidetes,1HZXV@117743|Flavobacteriia 976|Bacteroidetes CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,DUF4369 k59_536125_1 96561.Dole_0815 9.2e-127 368.0 COG5340@1|root,COG5340@2|Bacteria,1RDP9@1224|Proteobacteria,43BEB@68525|delta/epsilon subdivisions,2X6ST@28221|Deltaproteobacteria 28221|Deltaproteobacteria K AbiEi antitoxin C-terminal domain - - - - - - - - - - - - AbiEi_1 k59_536125_2 96561.Dole_0814 1.31e-182 523.0 COG2253@1|root,COG2253@2|Bacteria,1R66E@1224|Proteobacteria 1224|Proteobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - ko:K09144 - - - - ko00000 - - - AbiEii,WYL k59_536125_3 1123368.AUIS01000004_gene107 5.03e-97 297.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,1S4PB@1236|Gammaproteobacteria,2NE5E@225057|Acidithiobacillales 225057|Acidithiobacillales L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_436374_1 981384.AEYW01000001_gene1490 1.12e-38 142.0 COG1234@1|root,COG1234@2|Bacteria,1RIJP@1224|Proteobacteria 1224|Proteobacteria S Metallo-beta-lactamase superfamily - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_4 k59_568387_1 435837.HMPREF0798_02183 1.41e-24 94.0 2DMNG@1|root,32SP1@2|Bacteria,1VAXC@1239|Firmicutes,4HM1Q@91061|Bacilli,4H16H@90964|Staphylococcaceae 91061|Bacilli S COG NOG14552 non supervised orthologous group - - - - - - - - - - - - - k59_633838_1 298653.Franean1_1095 1.2e-13 73.2 COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4ERVK@85013|Frankiales 201174|Actinobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_305508_2 880071.Fleli_2541 1.01e-36 151.0 COG2425@1|root,COG2425@2|Bacteria,4NJ1T@976|Bacteroidetes 976|Bacteroidetes S protein containing a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - VWA_2,VWA_CoxE k59_763636_2 1265313.HRUBRA_02309 1.29e-63 212.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_959933_1 653733.Selin_0242 1.24e-11 61.6 COG1669@1|root,COG1669@2|Bacteria 2|Bacteria S nucleotidyltransferase activity - - - ko:K07075 - - - - ko00000 - - - NTP_transf_2 k59_959933_2 653733.Selin_0241 5.05e-16 73.9 COG2361@1|root,COG2361@2|Bacteria 2|Bacteria S Protein of unknown function DUF86 - - - - - - - - - - - - DUF86 k59_144201_1 439235.Dalk_0307 7.93e-64 202.0 COG0045@1|root,COG0045@2|Bacteria,1REBV@1224|Proteobacteria,42S1F@68525|delta/epsilon subdivisions,2WNW1@28221|Deltaproteobacteria,2MJUN@213118|Desulfobacterales 28221|Deltaproteobacteria C ATP-grasp domain - - - - - - - - - - - - ATP-grasp_5 k59_503746_1 566466.NOR53_2673 3.24e-72 232.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1J849@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes clsC GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0090483,GO:1901576 - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_894852_1 1499502.EV12_0302 4.61e-48 173.0 28HMZ@1|root,2Z7WD@2|Bacteria,1G31X@1117|Cyanobacteria 1117|Cyanobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1024943_1 338969.Rfer_2864 6.02e-252 715.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,4A9TI@80864|Comamonadaceae 28216|Betaproteobacteria KQ GAF modulated sigma54 specific transcriptional regulator, Fis family - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_1024943_2 305700.B447_20106 0.0 882.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,2KUIG@206389|Rhodocyclales 206389|Rhodocyclales C belongs to the aldehyde dehydrogenase family - - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh k59_1024943_3 243159.AFE_1743 2.46e-65 201.0 COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,1S7GJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF779) - - - ko:K09959 - - - - ko00000 - - - DUF779 k59_1024943_5 1298593.TOL_1181 1.35e-103 306.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,1XPIB@135619|Oceanospirillales 135619|Oceanospirillales F COG0518 GMP synthase - Glutamine amidotransferase domain - - - - - - - - - - - - GATase k59_1024943_6 1266908.AQPB01000060_gene186 1.76e-64 231.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RSH7@1236|Gammaproteobacteria,1WXXW@135613|Chromatiales 135613|Chromatiales NT HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_1024943_7 1123518.ARWI01000001_gene544 6.34e-35 125.0 COG0607@1|root,COG0607@2|Bacteria,1R2IR@1224|Proteobacteria 1224|Proteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_1024943_10 1121878.AUGL01000013_gene2931 4.6e-52 168.0 COG3431@1|root,COG3431@2|Bacteria,1N4JH@1224|Proteobacteria,1T11Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphate-starvation-inducible E - - - - - - - - - - - - PsiE k59_1024943_11 445335.CBN_1041 6.55e-49 161.0 COG3467@1|root,COG3467@2|Bacteria,1V7MR@1239|Firmicutes,25B09@186801|Clostridia,36W93@31979|Clostridiaceae 186801|Clostridia S Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_1024943_12 991.IW20_09940 1.63e-72 239.0 COG4487@1|root,COG4487@2|Bacteria,4NGZ9@976|Bacteroidetes,1HZ50@117743|Flavobacteriia,2NV85@237|Flavobacterium 976|Bacteroidetes S Uncharacterized protein conserved in bacteria (DUF2130) - - - - - - - - - - - - DUF2130 k59_1024943_13 1286106.MPL1_09597 4.59e-172 489.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,4602Y@72273|Thiotrichales 72273|Thiotrichales C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_1024943_16 1049564.TevJSym_ap00410 0.0 1075.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1J4NM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1024943_17 1248232.BANQ01000005_gene1966 4.8e-35 121.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,1XXSE@135623|Vibrionales 135623|Vibrionales J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_1024943_18 1049564.TevJSym_ap00430 3.61e-143 412.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1J4X5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_1024943_19 1182590.BN5_03089 3.16e-39 135.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1YGFI@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_1024943_20 1049564.TevJSym_ap00450 0.0 966.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_1024943_21 1049564.TevJSym_ap00460 7.79e-242 678.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1J4C0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1024943_22 765911.Thivi_3166 1.04e-51 169.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1WY8Z@135613|Chromatiales 135613|Chromatiales S Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_1024943_24 290317.Cpha266_2198 3.07e-159 454.0 COG2301@1|root,COG2301@2|Bacteria 2|Bacteria G Belongs to the HpcH HpaI aldolase family citE - 4.1.3.25,4.1.3.34 ko:K01644,ko:K18292 ko00660,ko01100,ko02020,map00660,map01100,map02020 - R00237,R00362 RC00067,RC00502,RC01118,RC01205 ko00000,ko00001,ko01000 - - - C-C_Bond_Lyase,HpcH_HpaI k59_1024943_25 631362.Thi970DRAFT_04512 4.28e-78 246.0 COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,1RY54@1236|Gammaproteobacteria,1WWFU@135613|Chromatiales 135613|Chromatiales O peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase k59_1024943_26 519989.ECTPHS_05210 8.99e-55 176.0 COG0760@1|root,COG0760@2|Bacteria,1QUCX@1224|Proteobacteria,1S6X5@1236|Gammaproteobacteria,1WY5W@135613|Chromatiales 135613|Chromatiales O PFAM NifZ - - - ko:K02597 - - - - ko00000 - - - NifZ k59_1024943_27 768671.ThimaDRAFT_2945 2.01e-30 112.0 2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,1S999@1236|Gammaproteobacteria,1WYNZ@135613|Chromatiales 135613|Chromatiales J May protect the nitrogenase Fe-Mo protein from oxidative damage nifW - - ko:K02595 - - - - ko00000 - - - NifW k59_1024943_28 1249627.D779_3155 5.19e-166 476.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RRGA@1236|Gammaproteobacteria,1WX0C@135613|Chromatiales 135613|Chromatiales E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_179576_2 1049564.TevJSym_ad00270 7.38e-112 340.0 COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,1S0HQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C overlaps another CDS with the same product name - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_636689_1 425104.Ssed_3344 1.88e-27 117.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q8QJ@267890|Shewanellaceae 1236|Gammaproteobacteria T SMART PAS domain containing protein - - - - - - - - - - - - CHASE,EAL,GGDEF,MASE1,PAS,PAS_4,PAS_9,Response_reg k59_374682_1 1121943.KB899991_gene2402 7.09e-93 293.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1XI6C@135619|Oceanospirillales 135619|Oceanospirillales I acetoacetyl-CoA - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_343334_1 323261.Noc_0961 3.83e-53 189.0 COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,1RP2H@1236|Gammaproteobacteria,1WWY9@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_539140_1 335543.Sfum_1941 9.52e-118 345.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2MR9Y@213462|Syntrophobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_374689_1 1122179.KB890459_gene985 7.92e-65 217.0 COG0642@1|root,COG2205@2|Bacteria,4NGAS@976|Bacteroidetes,1IUW2@117747|Sphingobacteriia 976|Bacteroidetes T HAMP domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,TPR_8 k59_147099_1 768671.ThimaDRAFT_1462 6.54e-71 239.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T23Q@1236|Gammaproteobacteria,1WXM7@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_796042_1 1168034.FH5T_02920 2.94e-113 334.0 COG1894@1|root,COG1894@2|Bacteria,4P09J@976|Bacteroidetes,2FXDI@200643|Bacteroidia 976|Bacteroidetes C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - - - - - - - - - - - Complex1_51K,NADH_4Fe-4S k59_931010_1 1122149.BACN01000037_gene985 1.37e-07 56.2 COG0818@1|root,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,4HNKN@91061|Bacilli,3F7DC@33958|Lactobacillaceae 91061|Bacilli M Diacylglycerol kinase dgkA - 2.7.1.107,2.7.1.66 ko:K00887,ko:K00901 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240,R05626 RC00002,RC00017 ko00000,ko00001,ko01000 - - iSB619.SA_RS07900 DAGK_prokar k59_343345_1 1168034.FH5T_07815 6.57e-133 394.0 COG0445@1|root,COG0445@2|Bacteria,4NFNH@976|Bacteroidetes,2FMA5@200643|Bacteroidia 976|Bacteroidetes D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_669812_1 1306174.JODP01000004_gene1043 2.51e-06 50.1 COG0605@1|root,COG0605@2|Bacteria,2GJV8@201174|Actinobacteria 201174|Actinobacteria P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodA GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0010035,GO:0016020,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0020012,GO:0030682,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052059,GO:0052173,GO:0052200,GO:0052385,GO:0052550,GO:0052564,GO:0052567,GO:0052572,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:0072593,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - iNJ661.Rv3846 Sod_Fe_C,Sod_Fe_N k59_9929_1 862965.PARA_18730 5.26e-87 286.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1Y7XT@135625|Pasteurellales 135625|Pasteurellales EGIPQ Phosphate acyltransferases - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_733499_1 1168034.FH5T_05055 1.87e-86 260.0 COG1043@1|root,COG1043@2|Bacteria,4NEBA@976|Bacteroidetes,2FKYH@200643|Bacteroidia 976|Bacteroidetes M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_733499_2 1168034.FH5T_05060 1.58e-124 362.0 COG0611@1|root,COG0611@2|Bacteria,4NDUT@976|Bacteroidetes,2FN7K@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_180070_1 1121035.AUCH01000017_gene2261 1.52e-60 191.0 COG2259@1|root,COG2259@2|Bacteria,1RDRZ@1224|Proteobacteria,2VS2G@28216|Betaproteobacteria,2KYXS@206389|Rhodocyclales 206389|Rhodocyclales S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_180070_2 526225.Gobs_2965 3.84e-90 284.0 COG0508@1|root,COG1249@1|root,COG0508@2|Bacteria,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria 201174|Actinobacteria C Dehydrogenase lpdA_1 - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_275375_1 177437.HRM2_45610 2.15e-133 389.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2MISS@213118|Desulfobacterales 28221|Deltaproteobacteria P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_539579_1 1215092.PA6_006_02450 6.29e-34 129.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1YCWG@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_539579_2 309807.SRU_2221 6.68e-101 313.0 COG0165@1|root,COG0165@2|Bacteria,4NFCY@976|Bacteroidetes,1FJSI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Lyase_1 k59_832658_1 1125863.JAFN01000001_gene1984 1.76e-09 56.6 COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2WPQC@28221|Deltaproteobacteria 28221|Deltaproteobacteria EJ PFAM Asparaginase aspG - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_832658_2 713586.KB900536_gene934 3.85e-44 158.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1WXRD@135613|Chromatiales 135613|Chromatiales O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD k59_963363_2 1123236.KB899391_gene3394 1e-63 201.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,466EY@72275|Alteromonadaceae 1236|Gammaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_733515_2 572544.Ilyop_1427 3.87e-224 628.0 COG2211@1|root,COG2211@2|Bacteria,3783P@32066|Fusobacteria 32066|Fusobacteria G Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_46385_1 1178482.BJB45_03810 1.24e-43 154.0 COG3181@1|root,COG3181@2|Bacteria,1R5C8@1224|Proteobacteria,1S1K9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ABC transporter substrate-binding protein - - - - - - - - - - - - - k59_244120_1 489825.LYNGBM3L_19950 2.02e-24 107.0 COG0668@1|root,COG0668@2|Bacteria,1G1N6@1117|Cyanobacteria,1H8JA@1150|Oscillatoriales 1117|Cyanobacteria M mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_407482_1 314270.RB2083_2750 3.68e-98 304.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria 1224|Proteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component MA20_18685 - - - - - - - - - - - DctM k59_963368_1 83219.PM02_17630 2.07e-68 208.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,3ZY1Y@60136|Sulfitobacter 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_963368_2 1123247.AUIJ01000043_gene803 1.55e-104 310.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_32,rve,rve_3 k59_767257_2 1128421.JAGA01000003_gene3714 3.93e-24 105.0 COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria 2|Bacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K03694,ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_375253_2 1123502.AQXD01000003_gene1619 1.97e-32 127.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1X3IQ@135614|Xanthomonadales 135614|Xanthomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1028277_1 472759.Nhal_3892 1.09e-61 212.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_407495_1 572544.Ilyop_1346 2.79e-38 144.0 29XI0@1|root,30J8T@2|Bacteria,37929@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_507418_2 572544.Ilyop_0348 4.52e-166 473.0 COG1186@1|root,COG1186@2|Bacteria,378NM@32066|Fusobacteria 32066|Fusobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1028280_1 322710.Avin_44850 6.08e-48 164.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria 1236|Gammaproteobacteria M lipopolysaccharide heptosyltransferase I rfaC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107 Glyco_transf_9 k59_1028280_2 395961.Cyan7425_3345 2.96e-31 116.0 COG0529@1|root,COG0529@2|Bacteria,1G21C@1117|Cyanobacteria,3KGJR@43988|Cyanothece 1117|Cyanobacteria F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_244143_1 572477.Alvin_1919 5.57e-74 239.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales 135613|Chromatiales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_702064_1 1249627.D779_2607 1.6e-25 108.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WXNX@135613|Chromatiales 135613|Chromatiales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_439706_1 335543.Sfum_3425 6.72e-36 129.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria 1224|Proteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway - - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23 k59_539600_1 979556.MTES_3479 1.43e-53 181.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FKH2@85023|Microbacteriaceae 201174|Actinobacteria I Thiolase, C-terminal domain fadA - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_308950_2 96561.Dole_3044 1.69e-60 211.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_539604_1 543728.Vapar_0725 2.01e-65 211.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VRHD@28216|Betaproteobacteria,4AJA6@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_733540_1 991905.SL003B_1030 1.75e-12 67.4 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_733540_2 1121033.AUCF01000016_gene5531 1.22e-26 109.0 COG0845@1|root,COG0845@2|Bacteria,1Q10W@1224|Proteobacteria,2TSC8@28211|Alphaproteobacteria,2JRIP@204441|Rhodospirillales 204441|Rhodospirillales M HlyD family secretion protein - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_604742_1 1163617.SCD_n00877 5.07e-05 53.9 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria 28216|Betaproteobacteria NU pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - LysM k59_275399_1 425104.Ssed_1524 5.34e-60 198.0 COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria,2QAN2@267890|Shewanellaceae 1236|Gammaproteobacteria C TIGRFAM cytochrome C family protein - - - - - - - - - - - - Cytochrome_C554,Paired_CXXCH_1 k59_702079_1 314345.SPV1_08461 6.92e-85 263.0 COG3395@1|root,COG3395@2|Bacteria 2|Bacteria S kinase activity - - - - - - - - - - - - DUF1357_C,DUF1537 k59_10383_1 572480.Arnit_1513 2.58e-78 257.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,42MP9@68525|delta/epsilon subdivisions 1224|Proteobacteria V ABC transporter, transmembrane region cydC - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran k59_931407_2 667632.KB890177_gene4318 8.98e-06 51.6 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VR7H@28216|Betaproteobacteria,1K1TE@119060|Burkholderiaceae 28216|Betaproteobacteria M repeat-containing protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 k59_931408_1 1408439.JHXW01000003_gene1552 3.97e-58 183.0 COG1803@1|root,COG1803@2|Bacteria,37A6J@32066|Fusobacteria 32066|Fusobacteria G MGS-like domain mgsA - 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - - MGS k59_343810_1 1165841.SULAR_04417 4.69e-86 272.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2YMEF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M penicillin-binding protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_963407_1 1123248.KB893318_gene4111 2.32e-43 147.0 COG2010@1|root,COG2010@2|Bacteria,4NQXA@976|Bacteroidetes,1IT61@117747|Sphingobacteriia 976|Bacteroidetes C PFAM Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_472687_1 765913.ThidrDRAFT_2226 2.06e-57 189.0 COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,1RSB2@1236|Gammaproteobacteria,1WX39@135613|Chromatiales 135613|Chromatiales O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureD - - ko:K03190 - - - - ko00000 - - - UreD k59_604753_1 571166.KI421509_gene1179 5.38e-70 228.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_539625_1 258533.BN977_04931 1.1e-20 95.5 COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,232YE@1762|Mycobacteriaceae 201174|Actinobacteria H biotin lipoate A B protein ligase birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB k59_796570_1 1049564.TevJSym_af00510 3.64e-76 236.0 COG4122@1|root,COG4122@2|Bacteria,1RASF@1224|Proteobacteria,1S38Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_796570_2 289376.THEYE_A1138 6.82e-11 62.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3J101@40117|Nitrospirae 40117|Nitrospirae G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_963419_1 709032.Sulku_1839 1.62e-149 436.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2YMWQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_832703_1 1463858.JOHR01000001_gene6802 1.76e-36 142.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria 201174|Actinobacteria C CoA-binding domain protein acdA1 - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_733560_1 1249627.D779_1371 1.63e-131 388.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_439736_1 1049564.TevJSym_ao00100 4.48e-98 296.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1J4IQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0303 Molybdopterin biosynthesis enzyme moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_796577_1 1123253.AUBD01000008_gene518 4.68e-74 248.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1X3T3@135614|Xanthomonadales 135614|Xanthomonadales EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_407535_1 765914.ThisiDRAFT_0694 2.76e-24 101.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1WXCW@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_407535_2 477228.YO5_08018 1.84e-95 295.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1Z0DM@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 GATase,GMP_synt_C,NAD_synthase k59_637232_2 563040.Saut_0542 2.43e-35 126.0 2AVG9@1|root,31M8F@2|Bacteria,1QJ39@1224|Proteobacteria,42W1H@68525|delta/epsilon subdivisions,2YQB8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_604761_1 563040.Saut_1880 1.09e-94 297.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,43BJ8@68525|delta/epsilon subdivisions,2YMMJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M penicillin-binding protein pbpA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_963422_1 56110.Oscil6304_6055 6.24e-52 177.0 COG3335@1|root,COG3335@2|Bacteria,1G4FA@1117|Cyanobacteria,1HBRR@1150|Oscillatoriales 1117|Cyanobacteria L K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_472719_1 675635.Psed_4004 1.17e-91 285.0 COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4EAET@85010|Pseudonocardiales 201174|Actinobacteria I Acetyl-CoA dehydrogenase C-terminal like - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_80778_1 1249480.B649_05400 5.01e-91 281.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2YMGS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_80778_2 521460.Athe_1405 5.11e-17 80.5 COG0126@1|root,COG0149@1|root,COG0126@2|Bacteria,COG0149@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales 186801|Clostridia F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_733578_1 768671.ThimaDRAFT_1156 9.49e-20 90.9 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales 135613|Chromatiales D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_733578_2 765911.Thivi_3765 7.17e-14 69.7 COG4313@1|root,COG4313@2|Bacteria,1ND6Y@1224|Proteobacteria,1RYD3@1236|Gammaproteobacteria,1WW33@135613|Chromatiales 135613|Chromatiales C Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_80793_1 1168034.FH5T_05930 9.86e-80 262.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,2FMH3@200643|Bacteroidia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran,OEP k59_113810_1 243233.MCA0817 1.16e-97 303.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1XDS0@135618|Methylococcales 135618|Methylococcales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_767313_1 1232410.KI421426_gene1416 1.83e-41 155.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,43S1D@69541|Desulfuromonadales 28221|Deltaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_180154_2 85643.Tmz1t_0176 4.57e-06 49.3 COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,2VKDX@28216|Betaproteobacteria,2KUVK@206389|Rhodocyclales 206389|Rhodocyclales Q depolymerase - - 3.1.1.75 ko:K05973 ko00650,map00650 - R05118 - ko00000,ko00001,ko01000 - - - - k59_767323_1 426114.THI_3123 4.01e-29 118.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VWKV@28216|Betaproteobacteria,1KP44@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_113829_1 379731.PST_2365 1.19e-54 182.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1Z122@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iJN746.PP_2469 Phe_tRNA-synt_N,tRNA-synt_2d k59_610033_2 572544.Ilyop_0995 1.05e-36 134.0 COG1376@1|root,COG1376@2|Bacteria,378W6@32066|Fusobacteria 32066|Fusobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - SH3_3,YkuD k59_119345_1 314285.KT71_02627 1.69e-83 272.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_1002094_1 1288826.MSNKSG1_04136 7.31e-33 122.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,46796@72275|Alteromonadaceae 1236|Gammaproteobacteria L Belongs to the DnaA family. HdA subfamily hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_968944_1 1232410.KI421418_gene2422 3.69e-20 88.6 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,43VZ4@69541|Desulfuromonadales 28221|Deltaproteobacteria O SelR domain msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_152911_1 931276.Cspa_c10110 3.49e-119 357.0 COG4412@1|root,COG4935@1|root,COG4412@2|Bacteria,COG4935@2|Bacteria,1UIJ6@1239|Firmicutes,24BZI@186801|Clostridia,36HGY@31979|Clostridiaceae 186801|Clostridia G M6 family metalloprotease domain protein - - - - - - - - - - - - Big_4,CW_binding_1,F5_F8_type_C,Laminin_G_3 k59_445148_1 492774.JQMB01000011_gene4527 7.79e-115 335.0 COG3739@1|root,COG3739@2|Bacteria,1PMEC@1224|Proteobacteria,2TRGD@28211|Alphaproteobacteria,4BBTW@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF817) - - - - - - - - - - - - DUF817 k59_675803_1 1120953.AUBH01000008_gene197 3.29e-05 51.6 COG2199@1|root,COG2199@2|Bacteria,1NV1F@1224|Proteobacteria,1T5PE@1236|Gammaproteobacteria 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF k59_577035_1 1335757.SPICUR_08030 6.75e-29 124.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales 135613|Chromatiales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_512796_1 1041147.AUFB01000011_gene1618 6.02e-24 106.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase cyaF - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_19,TPR_2,TPR_8 k59_478081_2 713586.KB900536_gene633 1.15e-28 106.0 2ECSY@1|root,336QI@2|Bacteria,1N9AZ@1224|Proteobacteria,1S9XM@1236|Gammaproteobacteria,1WYWD@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_349225_2 311402.Avi_1833 1.7e-19 84.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,4BE2N@82115|Rhizobiaceae 28211|Alphaproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_51677_1 1319815.HMPREF0202_00212 0.0 1053.0 COG0466@1|root,COG0466@2|Bacteria,3789S@32066|Fusobacteria 32066|Fusobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_738739_2 99598.Cal7507_2751 9.93e-46 165.0 COG0187@1|root,COG0187@2|Bacteria,1G139@1117|Cyanobacteria,1HIZ3@1161|Nostocales 1117|Cyanobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Intein_splicing,Toprim k59_544631_1 1167006.UWK_00104 4.14e-65 211.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MIG5@213118|Desulfobacterales 28221|Deltaproteobacteria E Bacterial transferase hexapeptide (six repeats) cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_801957_1 391603.FBALC1_09167 6.01e-26 102.0 COG0074@1|root,COG0074@2|Bacteria,4NE6B@976|Bacteroidetes,1HX04@117743|Flavobacteriia 976|Bacteroidetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA,Succ_CoA_lig k59_801957_2 411154.GFO_1767 1.65e-42 147.0 COG1028@1|root,COG1028@2|Bacteria,4NEAI@976|Bacteroidetes,1HXDZ@117743|Flavobacteriia 976|Bacteroidetes IQ reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_314224_1 933262.AXAM01000003_gene2868 4.11e-66 216.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2WIM5@28221|Deltaproteobacteria,2MI7T@213118|Desulfobacterales 28221|Deltaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_445164_2 226186.BT_2202 4.03e-06 48.1 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FKYX@200643|Bacteroidia,4AK5Y@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_936602_1 1123253.AUBD01000005_gene224 6.08e-46 154.0 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1X6EJ@135614|Xanthomonadales 135614|Xanthomonadales K Ribosomal-protein-alanine acetyltransferase rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_936602_2 631362.Thi970DRAFT_01911 0.0 901.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_936602_3 1121403.AUCV01000008_gene1627 4.11e-114 342.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42RAU@68525|delta/epsilon subdivisions,2WNNR@28221|Deltaproteobacteria,2MJSQ@213118|Desulfobacterales 28221|Deltaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_936602_4 1249627.D779_3750 1.09e-294 812.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1WWUB@135613|Chromatiales 135613|Chromatiales C Catalyzes the reversible hydration of fumarate to (S)- malate - - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_936602_7 765910.MARPU_10495 1.78e-07 53.1 2DQWF@1|root,3392H@2|Bacteria,1N93V@1224|Proteobacteria,1SFNS@1236|Gammaproteobacteria,1WZ6Y@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF2934) - - - - - - - - - - - - DUF2934 k59_349234_1 1208321.D104_04500 3.56e-27 102.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1XJHH@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_642600_1 1049564.TevJSym_aq00440 2.02e-227 636.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_544641_1 1232683.ADIMK_1018 8.6e-70 222.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,466W8@72275|Alteromonadaceae 1236|Gammaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_1033479_1 1121405.dsmv_2147 8.07e-34 124.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WN1U@28221|Deltaproteobacteria,2MICR@213118|Desulfobacterales 28221|Deltaproteobacteria P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_577048_1 1189619.pgond44_02298 1.63e-19 93.2 COG3547@1|root,COG3547@2|Bacteria,4NF2F@976|Bacteroidetes,1HXCM@117743|Flavobacteriia,4C2NG@83612|Psychroflexus 976|Bacteroidetes L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_51689_1 96561.Dole_1063 2.43e-79 249.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2MHQF@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the citrate synthase family citZ - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,HTH_17 k59_1002122_1 266264.Rmet_1281 3.17e-26 104.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2VH3K@28216|Betaproteobacteria,1K3J9@119060|Burkholderiaceae 28216|Betaproteobacteria O hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_1002122_2 266264.Rmet_1541 4.62e-51 176.0 COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,1KBJJ@119060|Burkholderiaceae 28216|Betaproteobacteria IJ Formyl transferase hoxX - - ko:K19640 - - - - ko00000,ko02022 - - - ECH_1,Formyl_trans_C,Formyl_trans_N k59_936620_1 631362.Thi970DRAFT_03306 1.54e-97 308.0 COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales 135613|Chromatiales M sucrose synthase - - 2.4.1.13 ko:K00695 ko00500,ko01100,map00500,map01100 - R00806 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000,ko01003 - GT4 - Glycos_transf_1,Sucrose_synth k59_738753_2 1496688.ER33_14805 1e-23 99.0 COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,22TKK@167375|Cyanobium 1117|Cyanobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_903480_1 1200792.AKYF01000017_gene5567 3.11e-36 143.0 COG0236@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksJ - - ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_968977_1 1168034.FH5T_04150 6.68e-105 318.0 COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,2FM28@200643|Bacteroidia 976|Bacteroidetes C Acyl-CoA dehydrogenase, C-terminal domain acd - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_dehyd_C k59_968977_2 1168034.FH5T_04155 8.54e-83 253.0 COG2025@1|root,COG2025@2|Bacteria,4NFSE@976|Bacteroidetes,2FMEK@200643|Bacteroidia 976|Bacteroidetes C Electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_280796_1 1120951.AUBG01000012_gene1528 1.11e-82 249.0 COG0806@1|root,COG0806@2|Bacteria,4NQF0@976|Bacteroidetes,1I17F@117743|Flavobacteriia 976|Bacteroidetes J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_280796_2 867900.Celly_1695 1.34e-27 106.0 COG4123@1|root,COG4123@2|Bacteria,4NG1X@976|Bacteroidetes,1HWPP@117743|Flavobacteriia,1F7R4@104264|Cellulophaga 976|Bacteroidetes J Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) smtA GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016430,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.223 ko:K15460 - - - - ko00000,ko01000,ko03016 - - - MTS k59_15943_2 1415780.JPOG01000001_gene2740 1.05e-56 198.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1XCEY@135614|Xanthomonadales 135614|Xanthomonadales C Molydopterin dinucleotide binding domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_445192_1 396588.Tgr7_2914 1.27e-27 111.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales 135613|Chromatiales F TIGRFAM dihydroorotase, multifunctional complex type - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_445192_2 1042375.AFPL01000046_gene2006 2.7e-29 113.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,465UN@72275|Alteromonadaceae 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_642616_1 946077.W5A_12861 9.38e-27 105.0 2E4QW@1|root,32ZJG@2|Bacteria,4NVXI@976|Bacteroidetes,1I36D@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF3995) - - - - - - - - - - - - DUF3995 k59_1033496_1 159087.Daro_0568 7.93e-22 95.9 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,2KVU3@206389|Rhodocyclales 1224|Proteobacteria C COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1033496_2 1049564.TevJSym_ad00270 3.26e-27 111.0 COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,1S0HQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C overlaps another CDS with the same product name - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_610075_1 641107.CDLVIII_4027 1.48e-16 77.4 COG0596@1|root,COG0596@2|Bacteria,1TSPF@1239|Firmicutes,24AD1@186801|Clostridia,36FJN@31979|Clostridiaceae 186801|Clostridia S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_936642_1 1267535.KB906767_gene5393 6.97e-19 82.0 COG3415@1|root,COG3415@2|Bacteria,3Y8WI@57723|Acidobacteria 57723|Acidobacteria L Winged helix-turn helix - - - - - - - - - - - - HTH_33 k59_969654_1 981384.AEYW01000001_gene1490 1.17e-62 205.0 COG1234@1|root,COG1234@2|Bacteria,1RIJP@1224|Proteobacteria 1224|Proteobacteria S Metallo-beta-lactamase superfamily - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_4 k59_610683_1 1120966.AUBU01000008_gene2552 1.62e-97 305.0 COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes,47NUP@768503|Cytophagia 976|Bacteroidetes V Domain of unknown function (DUF3471) - - - - - - - - - - - - Beta-lactamase,DUF3471 k59_250346_1 56107.Cylst_1517 3.36e-32 130.0 COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,1G1WS@1117|Cyanobacteria,1HMY3@1161|Nostocales 1117|Cyanobacteria IQ TIGRFAM amino acid adenylation domain mcyC - - ko:K16132 ko01054,map01054 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_545372_1 709032.Sulku_2157 2e-81 251.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2YMJU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_545372_2 563040.Saut_0511 7.9e-48 153.0 COG1145@1|root,COG1145@2|Bacteria,1QUJB@1224|Proteobacteria,42TSI@68525|delta/epsilon subdivisions,2YPU2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin fdxA - - - - - - - - - - - Fer4,Fer4_7 k59_904243_1 314345.SPV1_12250 3.84e-23 103.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria 1224|Proteobacteria O Highly conserved protein containing a thioredoxin domain yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_513617_2 1121374.KB891590_gene1719 1.7e-25 100.0 29R72@1|root,30C8E@2|Bacteria,1RE0P@1224|Proteobacteria,1S53D@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_802729_1 1223410.KN050846_gene1268 5.05e-77 238.0 COG4874@1|root,COG4874@2|Bacteria,4NFG3@976|Bacteroidetes,1HX0R@117743|Flavobacteriia 976|Bacteroidetes S protein conserved in bacteria containing a pentein-type domain - - - - - - - - - - - - Amidinotransf k59_802729_2 1123060.JONP01000002_gene1079 0.000175 44.7 COG0110@1|root,COG0110@2|Bacteria,1RA2T@1224|Proteobacteria,2U5F8@28211|Alphaproteobacteria,2JRP5@204441|Rhodospirillales 204441|Rhodospirillales S Maltose acetyltransferase - - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2,Mac k59_969661_2 765910.MARPU_03360 1.06e-99 301.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales 135613|Chromatiales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_1002859_1 443143.GM18_2977 5.11e-164 469.0 COG3177@1|root,COG3177@2|Bacteria,1MVW0@1224|Proteobacteria,42PZR@68525|delta/epsilon subdivisions,2WJCM@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Filamentation induced by cAMP - - - - - - - - - - - - Fic k59_349915_2 426114.THI_1623 1.7e-34 141.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,1KJZ4@119065|unclassified Burkholderiales 28216|Betaproteobacteria M TIGRFAM sugar transferase, PEP-CTERM system associated wcaJ - 2.7.8.40 ko:K21303 - - - - ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3 k59_349915_3 1038869.AXAN01000054_gene6174 3.85e-85 270.0 COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,2VK05@28216|Betaproteobacteria,1K33H@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_2,Glycos_transf_1 k59_577791_1 1121396.KB893069_gene1379 7.53e-06 48.5 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,42NKR@68525|delta/epsilon subdivisions,2WJIQ@28221|Deltaproteobacteria,2MISK@213118|Desulfobacterales 28221|Deltaproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_577791_2 177437.HRM2_37140 2.44e-24 100.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,42NX7@68525|delta/epsilon subdivisions,2WQ35@28221|Deltaproteobacteria,2MIN6@213118|Desulfobacterales 28221|Deltaproteobacteria N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_478762_1 1121472.AQWN01000004_gene835 1.59e-61 206.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,260H6@186807|Peptococcaceae 186801|Clostridia IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_349918_1 1265503.KB905168_gene1326 1.11e-61 200.0 COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,1RR06@1236|Gammaproteobacteria,2Q6JA@267889|Colwelliaceae 1236|Gammaproteobacteria K helix_turn_helix isocitrate lyase regulation Z012_01460 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K21602 - - - - ko00000,ko03000 - - - HTH_IclR,IclR k59_904257_1 1300345.LF41_2071 8.58e-51 183.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1X3V7@135614|Xanthomonadales 135614|Xanthomonadales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_413457_1 96561.Dole_2481 4.23e-77 252.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2MHMB@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent Clp protease ATP-binding subunit ClpA clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_281520_1 1158182.KB905024_gene114 7.67e-40 137.0 COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,1SAXA@1236|Gammaproteobacteria 1236|Gammaproteobacteria P belongs to the Fur family - - - ko:K09826 - - - - ko00000,ko03000 - - - FUR k59_513632_1 97138.C820_01473 7.53e-79 247.0 COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,36DHK@31979|Clostridiaceae 186801|Clostridia E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_643351_1 1304885.AUEY01000009_gene1952 3.93e-21 96.7 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42MBK@68525|delta/epsilon subdivisions,2WKDV@28221|Deltaproteobacteria,2MINH@213118|Desulfobacterales 28221|Deltaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_478771_1 1121935.AQXX01000085_gene5320 4.65e-133 395.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1XHWC@135619|Oceanospirillales 135619|Oceanospirillales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_577799_1 533240.CRC_02763 1.57e-24 105.0 COG1055@1|root,COG1055@2|Bacteria,1G0JP@1117|Cyanobacteria,1HIXI@1161|Nostocales 1117|Cyanobacteria P COGs COG1055 Na H antiporter NhaD and related arsenite permease - - - - - - - - - - - - CitMHS k59_250373_1 335543.Sfum_1994 2.16e-19 90.5 COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,43C2J@68525|delta/epsilon subdivisions,2X7D5@28221|Deltaproteobacteria,2MQEP@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_381420_1 1226994.AMZB01000082_gene284 7.38e-28 111.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1YDCF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_381420_2 1122197.ATWI01000009_gene1675 0.000859 42.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,4649H@72275|Alteromonadaceae 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_153630_1 1232437.KL662006_gene4371 2.35e-13 64.3 2CGS2@1|root,32S4H@2|Bacteria,1N2GM@1224|Proteobacteria,42TM5@68525|delta/epsilon subdivisions,2WQTK@28221|Deltaproteobacteria,2MKF0@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_153630_2 525897.Dbac_2078 7.31e-52 180.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2M8QF@213115|Desulfovibrionales 28221|Deltaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_478778_1 1415779.JOMH01000001_gene188 6.87e-37 132.0 COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,1RMVD@1236|Gammaproteobacteria,1X39H@135614|Xanthomonadales 135614|Xanthomonadales G Inositol monophosphatase family - - 3.1.3.15 ko:K05602 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_478778_2 330214.NIDE3598 7.85e-148 425.0 COG0702@1|root,COG0702@2|Bacteria 2|Bacteria GM epimerase - - - - - - - - - - - - NmrA k59_319736_1 522306.CAP2UW1_3313 2.41e-71 226.0 COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2VRBW@28216|Betaproteobacteria 28216|Betaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_876243_1 469618.FVAG_00534 3.18e-19 89.4 COG2148@1|root,COG2148@2|Bacteria,37984@32066|Fusobacteria 32066|Fusobacteria M Bacterial sugar transferase - - 2.7.8.6 ko:K00996 - - - - ko00000,ko01000,ko01005 - - - Bac_transf,CoA_binding_3 k59_876243_2 340177.Cag_0645 2.09e-33 125.0 2DQMF@1|root,337KW@2|Bacteria,1FESM@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - k59_159684_1 572544.Ilyop_0740 5e-99 300.0 COG1105@1|root,COG1105@2|Bacteria,3795W@32066|Fusobacteria 32066|Fusobacteria H Belongs to the carbohydrate kinase PfkB family pfkB - 2.7.1.56 ko:K00882 ko00051,map00051 - R02071 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_943450_1 756272.Plabr_3518 5.96e-19 87.0 COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,2IX8E@203682|Planctomycetes 203682|Planctomycetes O PA domain - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 k59_943450_2 384765.SIAM614_11768 2.11e-23 100.0 COG4625@1|root,COG4625@2|Bacteria 2|Bacteria T pathogenesis Z012_00010 - - - - - - - - - - - Autotransporter,Peptidase_S8 k59_388091_1 106370.Francci3_4220 1.7e-17 86.3 COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria 201174|Actinobacteria L required for the transposition of insertion element IS2404 - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_808339_2 455436.DS989815_gene2231 3.86e-81 248.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,464QZ@72275|Alteromonadaceae 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 ATP-synt_A k59_93169_1 469616.FMAG_00497 5.31e-89 282.0 COG1200@1|root,COG1200@2|Bacteria,378RT@32066|Fusobacteria 32066|Fusobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_93169_2 572544.Ilyop_1698 3.65e-158 455.0 COG2805@1|root,COG2805@2|Bacteria,379F6@32066|Fusobacteria 32066|Fusobacteria NU COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_93169_3 572544.Ilyop_1699 1.32e-268 752.0 COG0442@1|root,COG0442@2|Bacteria,378BI@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_93169_4 572544.Ilyop_1696 8.12e-23 91.7 COG0716@1|root,COG0716@2|Bacteria,37A1T@32066|Fusobacteria 32066|Fusobacteria C Low-potential electron donor to a number of redox enzymes - - - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 k59_452775_1 1168034.FH5T_01700 6.56e-38 140.0 COG1748@1|root,COG1748@2|Bacteria,4NFM8@976|Bacteroidetes 976|Bacteroidetes E Saccharopine dehydrogenase - - 1.5.1.10 ko:K00293 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R02315 RC00215,RC00225 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_452775_2 1168034.FH5T_01695 2.23e-60 202.0 COG1509@1|root,COG1509@2|Bacteria,4NI73@976|Bacteroidetes,2G2FN@200643|Bacteroidia 976|Bacteroidetes E lysine 2,3-aminomutase activity - - - - - - - - - - - - - k59_483955_1 1121923.GPUN_2639 5.13e-82 265.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,464P1@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG0514 Superfamily II DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_160374_1 1122169.AREN01000014_gene2740 1.07e-104 338.0 COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1MVGH@1224|Proteobacteria,1RQXN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L dEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_256320_1 743299.Acife_0035 2.8e-11 68.6 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,2NBRW@225057|Acidithiobacillales 225057|Acidithiobacillales O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_320313_1 582744.Msip34_2182 7.36e-34 125.0 COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,2VSGZ@28216|Betaproteobacteria,2KMRU@206350|Nitrosomonadales 206350|Nitrosomonadales S Belongs to the UPF0307 family - - - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_943472_1 572544.Ilyop_1118 1.07e-119 355.0 COG2239@1|root,COG2239@2|Bacteria,378KN@32066|Fusobacteria 32066|Fusobacteria P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_745256_1 1121007.AUML01000033_gene2787 2.49e-40 146.0 COG2367@1|root,COG2367@2|Bacteria,4NHT5@976|Bacteroidetes,1HWY4@117743|Flavobacteriia 976|Bacteroidetes V Beta-lactamase enzyme family - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_483974_1 700598.Niako_3608 6.44e-128 381.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1IRQA@117747|Sphingobacteriia 976|Bacteroidetes G Pectate lyase - - - - - - - - - - - - - k59_93181_1 457396.CSBG_01119 2.62e-08 54.3 COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,36I75@31979|Clostridiaceae 186801|Clostridia L Belongs to the DNA glycosylase MPG family - - 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco k59_93181_3 665571.STHERM_c04630 1.17e-97 303.0 COG0613@1|root,COG0613@2|Bacteria 2|Bacteria Q PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - DUF5001,PHP k59_808356_1 1165841.SULAR_05818 1.23e-83 260.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2YMZK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_355529_1 243233.MCA2691 1.23e-05 48.1 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales 135618|Methylococcales EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_584099_1 290317.Cpha266_2625 1.39e-17 80.1 COG3335@1|root,COG3335@2|Bacteria,1FEWD@1090|Chlorobi 1090|Chlorobi L Winged helix-turn helix - - - - - - - - - - - - HTH_32 k59_909879_1 290397.Adeh_2927 8.85e-55 191.0 COG5492@1|root,COG5492@2|Bacteria,1QY8X@1224|Proteobacteria,43CAR@68525|delta/epsilon subdivisions,2X7M8@28221|Deltaproteobacteria 28221|Deltaproteobacteria C domain, Protein - - - - - - - - - - - - - k59_452823_1 933262.AXAM01000005_gene2502 4.15e-41 136.0 COG3514@1|root,COG3514@2|Bacteria,1NA6F@1224|Proteobacteria,42WIF@68525|delta/epsilon subdivisions,2WR86@28221|Deltaproteobacteria,2MNZJ@213118|Desulfobacterales 28221|Deltaproteobacteria S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_452823_2 697282.Mettu_0807 1.35e-29 106.0 2E3EN@1|root,32YDN@2|Bacteria,1N7N7@1224|Proteobacteria,1SCSD@1236|Gammaproteobacteria,1XGTV@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF4160) - - - - - - - - - - - - DUF4160 k59_551942_1 1149133.ppKF707_3043 1.31e-114 340.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1YIDJ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_192370_1 768671.ThimaDRAFT_2764 6.18e-40 140.0 COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,1S3FR@1236|Gammaproteobacteria,1X02B@135613|Chromatiales 135613|Chromatiales E PFAM N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_551944_1 1168034.FH5T_17190 3.97e-26 102.0 COG0330@1|root,COG0330@2|Bacteria,4NFNB@976|Bacteroidetes 976|Bacteroidetes O COG0330 Membrane protease subunits stomatin prohibitin homologs - - - - - - - - - - - - Band_7 k59_551944_2 1168034.FH5T_17195 3.53e-62 193.0 COG2050@1|root,COG2050@2|Bacteria,4NRF7@976|Bacteroidetes,2G31E@200643|Bacteroidia 976|Bacteroidetes Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_22823_1 596315.HMPREF0634_1199 1.14e-09 59.3 COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,248XD@186801|Clostridia,25RJ1@186804|Peptostreptococcaceae 186801|Clostridia S Cobalamin synthesis protein cobW C-terminal domain cobW - - - - - - - - - - - CobW_C,cobW k59_22823_2 1235788.C802_02883 1.85e-45 162.0 COG0526@1|root,COG0526@2|Bacteria,4NH2A@976|Bacteroidetes,2FQU3@200643|Bacteroidia,4AQ2Y@815|Bacteroidaceae 976|Bacteroidetes CO Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin k59_779415_1 1168034.FH5T_11400 3.42e-25 102.0 COG0332@1|root,COG0332@2|Bacteria,4NEZE@976|Bacteroidetes,2FRWR@200643|Bacteroidia 976|Bacteroidetes I 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_779415_2 742817.HMPREF9449_02638 3.04e-51 172.0 COG2908@1|root,COG2908@2|Bacteria,4NEF1@976|Bacteroidetes,2FM2C@200643|Bacteroidia,22W7E@171551|Porphyromonadaceae 976|Bacteroidetes S UDP-2,3-diacylglucosamine hydrolase lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_22825_1 518766.Rmar_1593 3.69e-78 249.0 COG2987@1|root,COG2987@2|Bacteria,4NF2P@976|Bacteroidetes 976|Bacteroidetes E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_58762_1 1537917.JU82_10180 6.03e-71 221.0 COG0697@1|root,COG0697@2|Bacteria,1PIFB@1224|Proteobacteria,42QAN@68525|delta/epsilon subdivisions,2YNGI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG integral membrane protein (DUF6 domain protein) - - - - - - - - - - - - EamA k59_58762_2 1288963.ADIS_1013 4.9e-05 46.6 COG0679@1|root,COG0679@2|Bacteria,4NIQF@976|Bacteroidetes,47Q60@768503|Cytophagia 976|Bacteroidetes S PFAM Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_745285_1 1410622.JNKY01000018_gene664 9.59e-22 100.0 COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,27J0Y@186928|unclassified Lachnospiraceae 186801|Clostridia D Peptidase family M23 - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_616718_1 1121405.dsmv_0001 7.15e-57 181.0 COG4843@1|root,COG4843@2|Bacteria,1REIP@1224|Proteobacteria,42S29@68525|delta/epsilon subdivisions,2WNWG@28221|Deltaproteobacteria,2MKCT@213118|Desulfobacterales 28221|Deltaproteobacteria S protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 k59_224650_1 1049564.TevJSym_ab01230 1.43e-114 335.0 COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1040755_1 1095772.CAHH01000042_gene1214 7.72e-98 293.0 COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria 201174|Actinobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_419097_1 765913.ThidrDRAFT_1210 6.35e-63 200.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1WX9X@135613|Chromatiales 135613|Chromatiales O PFAM Peptidase M22, glycoprotease - - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_388191_1 1283300.ATXB01000001_gene2098 7.94e-112 332.0 COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1XGAT@135618|Methylococcales 135618|Methylococcales G Glycosyl hydrolase family 57 - - - - - - - - - - - - Glyco_hydro_57 k59_682370_1 926561.KB900618_gene449 1.09e-15 81.3 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia 186801|Clostridia S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_192396_1 1236542.BALM01000002_gene795 3.58e-67 207.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 ko:K00611,ko:K09065 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01398,R07245 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_192396_2 1408473.JHXO01000004_gene101 1.2e-121 355.0 COG0549@1|root,COG0549@2|Bacteria,4NITW@976|Bacteroidetes,2FNTV@200643|Bacteroidia 976|Bacteroidetes E Amino acid kinase family - - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k59_808388_1 96561.Dole_2310 3.54e-122 362.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2MHWE@213118|Desulfobacterales 28221|Deltaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_452860_1 313612.L8106_14590 1.16e-06 57.8 COG2730@1|root,COG2931@1|root,COG3386@1|root,COG2730@2|Bacteria,COG2931@2|Bacteria,COG3386@2|Bacteria,1G3DW@1117|Cyanobacteria,1HAZM@1150|Oscillatoriales 1117|Cyanobacteria Q Domain of unknown function (DUF4347) - - - - - - - - - - - - Calx-beta,DUF4114,DUF4347,HemolysinCabind k59_419101_1 640513.Entas_2802 1.27e-28 114.0 COG0438@1|root,COG0438@2|Bacteria,1QU2N@1224|Proteobacteria,1RYA1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0438 Glycosyltransferase - - - - - - - - - - - - Glyco_trans_1_4 k59_355591_1 929558.SMGD1_2646 6.64e-80 249.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2YMKF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M ABC-type transport system involved in lipoprotein release permease component lolC - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_616734_1 1384056.N787_03745 1.4e-67 228.0 COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,1SHAC@1236|Gammaproteobacteria,1X3IB@135614|Xanthomonadales 135614|Xanthomonadales S Dak2 - - - ko:K07030 - - - - ko00000 - - - Dak2,DegV k59_484042_2 472759.Nhal_3454 5.23e-46 156.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales 135613|Chromatiales O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_584130_1 1165841.SULAR_08142 7.9e-37 136.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,42MWP@68525|delta/epsilon subdivisions,2YNEC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Oxidoreductase - - 1.1.99.3 ko:K06151 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_584130_2 1165841.SULAR_08137 6.35e-08 54.7 COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1N0EE@1224|Proteobacteria,43AQ7@68525|delta/epsilon subdivisions,2YSYN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Lysin motif - - - - - - - - - - - - LysM,NLPC_P60 k59_616737_1 1300345.LF41_1218 2.45e-35 127.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1X4J2@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_616737_2 1158165.KB898874_gene1596 2.35e-26 105.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1WXRN@135613|Chromatiales 135613|Chromatiales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_287858_1 387093.SUN_0142 1.95e-75 236.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2YMXF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_745297_1 1123020.AUIE01000016_gene1982 7.57e-63 209.0 29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1040772_1 1121937.AUHJ01000003_gene3176 3.5e-34 126.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2,Polysacc_deac_1 k59_1040772_2 638302.HMPREF0908_1278 1.11e-23 96.3 COG1898@1|root,COG1898@2|Bacteria,1V3X4@1239|Firmicutes,4H53U@909932|Negativicutes 909932|Negativicutes M WxcM-like protein - - - - - - - - - - - - FdtA k59_909947_1 314278.NB231_07352 1.07e-51 176.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales 135613|Chromatiales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_355596_1 572544.Ilyop_0372 2.95e-52 175.0 COG0772@1|root,COG0772@2|Bacteria,3783Y@32066|Fusobacteria 32066|Fusobacteria D Belongs to the SEDS family mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_355596_3 572544.Ilyop_0401 1.23e-132 384.0 COG0777@1|root,COG0777@2|Bacteria,378WG@32066|Fusobacteria 32066|Fusobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_355596_4 1408287.AXUR01000049_gene936 2.22e-73 229.0 COG0825@1|root,COG0825@2|Bacteria,378KC@32066|Fusobacteria 32066|Fusobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_419113_1 94624.Bpet3416 7.35e-99 305.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,3T23H@506|Alcaligenaceae 28216|Betaproteobacteria IQ Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_714186_1 387092.NIS_0929 1.08e-26 111.0 COG3174@1|root,COG3174@2|Bacteria,1RA19@1224|Proteobacteria,42PB8@68525|delta/epsilon subdivisions,2YNQN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010 k59_58795_1 160799.PBOR_24275 1.19e-27 120.0 COG1196@1|root,COG1196@2|Bacteria,1TQY7@1239|Firmicutes,4HCRF@91061|Bacilli,26W4B@186822|Paenibacillaceae 91061|Bacilli D nuclear chromosome segregation - - - - - - - - - - - - AAA_23,AAA_27 k59_93234_1 936589.HMPREF1521_0197 1.1e-70 238.0 COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,4H27V@909932|Negativicutes 909932|Negativicutes P Potassium transporter peripheral membrane component trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_93234_2 1121451.DESAM_22277 1.11e-101 313.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2M8CP@213115|Desulfovibrionales 28221|Deltaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_419121_1 1134474.O59_001948 1.68e-44 158.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1FG97@10|Cellvibrio 1236|Gammaproteobacteria C FAD dependent oxidoreductase eryB - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO k59_1040787_1 1150621.SMUL_2788 4.96e-76 236.0 COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2YNXM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Epimerase - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_1008496_1 1168034.FH5T_01625 2.54e-36 135.0 COG5557@1|root,COG5557@2|Bacteria 2|Bacteria C Polysulphide reductase, NrfD hmcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - NrfD k59_808423_1 203119.Cthe_1246 1.96e-72 234.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,3WHMW@541000|Ruminococcaceae 186801|Clostridia F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS04230 AICARFT_IMPCHas,MGS k59_320373_2 1134474.O59_002517 1.79e-195 543.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1S1B0@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives - - 2.5.1.15 ko:K18974 ko00790,ko01100,map00790,map01100 - R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko01000,ko01504 - - - Pterin_bind k59_320373_3 1177594.MIC448_1230003 5.97e-75 224.0 COG2076@1|root,COG2076@2|Bacteria 2|Bacteria P Multidrug Resistance protein emrE - - ko:K03297,ko:K18975 - - - - ko00000,ko02000 2.A.7.1,2.A.7.1.11 - - Multi_Drug_Res k59_457890_1 883.DvMF_1251 4e-19 89.7 COG0642@1|root,COG2984@1|root,COG0642@2|Bacteria,COG2984@2|Bacteria,1NXDJ@1224|Proteobacteria,43BMJ@68525|delta/epsilon subdivisions,2WUEV@28221|Deltaproteobacteria,2MH9E@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_457890_2 1190603.AJYD01000033_gene1815 9.62e-31 117.0 COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,1RR7M@1236|Gammaproteobacteria,1XUEH@135623|Vibrionales 135623|Vibrionales P ABC-type phosphate phosphonate transport system, periplasmic component - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_980883_1 1173029.JH980292_gene2882 7.01e-56 177.0 28N0M@1|root,2ZB6Z@2|Bacteria,1G4ZR@1117|Cyanobacteria 1117|Cyanobacteria S Toxin with endonuclease activity, of toxin-antitoxin system - - - ko:K19155 - - - - ko00000,ko01000,ko02048 - - - Toxin_YhaV k59_980883_2 644801.Psest_0883 1.14e-38 132.0 COG2002@1|root,COG2002@2|Bacteria,1RIAX@1224|Proteobacteria,1SC9R@1236|Gammaproteobacteria,1Z3NB@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K prlF antitoxin for toxin YhaV_toxin sohA GO:0001558,GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0040008,GO:0042802,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K19156 - - - - ko00000,ko02048 - - - PrlF_antitoxin k59_948212_1 272134.KB731324_gene4538 2.23e-08 59.3 COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,1G09B@1117|Cyanobacteria,1H7T9@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_523269_1 96561.Dole_2104 5.55e-71 223.0 COG1145@1|root,COG1145@2|Bacteria,1PW12@1224|Proteobacteria,42MZ9@68525|delta/epsilon subdivisions,2WN0W@28221|Deltaproteobacteria,2MHYH@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Fer4_6 k59_32960_1 269797.Mbar_A3489 7.83e-48 167.0 COG3385@1|root,arCOG04496@2157|Archaea,2Y7GJ@28890|Euryarchaeota,2N9SD@224756|Methanomicrobia 224756|Methanomicrobia L Transposase DDE domain - - - ko:K07495 - - - - ko00000 - - - DDE_Tnp_1 k59_980892_1 1122137.AQXF01000001_gene2623 7.16e-66 218.0 COG2268@1|root,COG2268@2|Bacteria,1P50K@1224|Proteobacteria,2TTVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria MA20_13940 - - - - - - - - - - - Band_7,Flot k59_196394_1 929558.SMGD1_1612 7.4e-32 117.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2YMQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_261789_1 1341157.RF007C_06135 4.26e-12 69.3 COG0454@1|root,COG0456@2|Bacteria,1V1WF@1239|Firmicutes,24N1J@186801|Clostridia,3WIN7@541000|Ruminococcaceae 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_130995_3 1537915.JU57_04560 1.02e-84 254.0 2ANB7@1|root,31D9H@2|Bacteria,1QADX@1224|Proteobacteria,42WGM@68525|delta/epsilon subdivisions,2YQM8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_294472_1 697329.Rumal_2918 1.46e-08 55.8 COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,3WGVS@541000|Ruminococcaceae 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_294472_2 1476973.JMMB01000007_gene162 2.33e-155 476.0 COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,25QJF@186804|Peptostreptococcaceae 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_32982_1 1255043.TVNIR_1681 4.91e-188 539.0 COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,1RNHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Ribonucleoside-triphosphate reductase nrdD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019001,GO:0019103,GO:0019438,GO:0019637,GO:0019692,GO:0030554,GO:0031250,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032556,GO:0032558,GO:0032559,GO:0032560,GO:0032564,GO:0032567,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0046872,GO:0046914,GO:0051065,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_4713,iPC815.YPO3454 ATP-cone,NRDD k59_850213_1 1499967.BAYZ01000048_gene2693 9.86e-42 154.0 COG0488@1|root,COG0488@2|Bacteria 2|Bacteria L (ABC) transporter - - - ko:K15738,ko:K18231 ko02010,map02010 - - - br01600,ko00000,ko00001,ko01504,ko02000 3.A.1.120.6,3.A.1.121.1,3.A.1.121.3 - - ABC_tran k59_556007_1 1458427.BAWN01000012_gene708 3.29e-12 66.6 COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,4AJCJ@80864|Comamonadaceae 28216|Betaproteobacteria K WYL domain - - - - - - - - - - - - HTH_11,WYL k59_556007_2 1384054.N790_05765 5.06e-10 59.3 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1X3W3@135614|Xanthomonadales 135614|Xanthomonadales L Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_392575_1 1168034.FH5T_12035 6.77e-43 156.0 COG4447@1|root,COG4447@2|Bacteria,4NEZQ@976|Bacteroidetes,2FVX6@200643|Bacteroidia 976|Bacteroidetes S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 k59_817480_1 1038858.AXBA01000007_gene1057 5.09e-16 78.2 COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,2U84T@28211|Alphaproteobacteria,3EZR4@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_359864_1 1168034.FH5T_04080 4.08e-107 339.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FM37@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_588716_1 525898.Sdel_1163 2.89e-86 267.0 COG2207@1|root,COG2207@2|Bacteria,1MUEM@1224|Proteobacteria,42PBT@68525|delta/epsilon subdivisions,2YN9A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - AraC_N,HTH_18 k59_588716_2 1121904.ARBP01000030_gene1961 5.15e-69 220.0 COG1064@1|root,COG1064@2|Bacteria,4NFGP@976|Bacteroidetes,47K0T@768503|Cytophagia 976|Bacteroidetes S alcohol dehydrogenase - - - ko:K13979 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_457941_1 620914.JH621246_gene2748 4.02e-05 46.2 COG0464@1|root,COG0464@2|Bacteria,4NFWG@976|Bacteroidetes,1HZA4@117743|Flavobacteriia,2YI1T@290174|Aquimarina 976|Bacteroidetes O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_457941_2 344747.PM8797T_07534 4.39e-31 122.0 COG1073@1|root,COG1073@2|Bacteria,2IWT8@203682|Planctomycetes 203682|Planctomycetes S alpha beta - - - - - - - - - - - - - k59_784788_2 216142.LT40_09675 1.66e-54 179.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Exodeoxyribonuclease III xthA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008853,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_163748_1 1349822.NSB1T_13700 8.75e-45 156.0 COG2871@1|root,COG2871@2|Bacteria,4NFKC@976|Bacteroidetes,2FN44@200643|Bacteroidia,22WRI@171551|Porphyromonadaceae 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF - 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_98365_1 396588.Tgr7_2113 1.23e-41 156.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_654102_1 552811.Dehly_1677 1.54e-115 366.0 COG0507@1|root,COG0782@1|root,COG1112@1|root,COG0507@2|Bacteria,COG0782@2|Bacteria,COG1112@2|Bacteria 2|Bacteria L Superfamily I DNA and RNA helicases and helicase subunits - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,DUF559,GreA_GreB k59_425235_1 1168034.FH5T_00875 3.03e-54 181.0 COG0657@1|root,COG0657@2|Bacteria,4PKDQ@976|Bacteroidetes,2G2RJ@200643|Bacteroidia 976|Bacteroidetes I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 k59_457947_1 95619.PM1_0206665 3.34e-13 68.6 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_457947_2 1260251.SPISAL_06805 1.77e-79 248.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales 135613|Chromatiales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_327229_4 498761.HM1_0076 1.4e-30 124.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia 186801|Clostridia G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C k59_621395_1 713587.THITH_10390 9.18e-82 265.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WWIV@135613|Chromatiales 135613|Chromatiales G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_457949_1 1168034.FH5T_12460 4.76e-128 379.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,4NEXG@976|Bacteroidetes,2G2WR@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_196425_1 443254.Marpi_1198 1.04e-84 265.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2GE5D@200918|Thermotogae 200918|Thermotogae M sugar transferase - - 2.7.8.6 ko:K00996 - - - - ko00000,ko01000,ko01005 - - - Bac_transf,CoA_binding_3 k59_392594_1 387093.SUN_2119 2.49e-39 132.0 COG3077@1|root,COG3077@2|Bacteria,1NGDT@1224|Proteobacteria,42WTT@68525|delta/epsilon subdivisions,2YQYH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L RelB antitoxin - - - ko:K07473 - - - - ko00000,ko02048 - - - RelB k59_392594_2 90813.JQMT01000001_gene852 1.94e-26 100.0 2EJQ5@1|root,33DEZ@2|Bacteria,1NGE9@1224|Proteobacteria,1SI4D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4282) - - - - - - - - - - - - DUF4282 k59_719484_1 338969.Rfer_2799 1.96e-35 136.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,4A9VY@80864|Comamonadaceae 28216|Betaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_490621_1 1168034.FH5T_07460 1.96e-98 300.0 COG4623@1|root,COG4623@2|Bacteria,4NHFW@976|Bacteroidetes,2FN2R@200643|Bacteroidia 976|Bacteroidetes M Transglycosylase SLT domain protein mltF - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_654120_1 522306.CAP2UW1_3471 1.8e-48 158.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2VR2K@28216|Betaproteobacteria,1KQ02@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_654120_2 34506.g5327 2.99e-10 60.5 COG0097@1|root,COG0098@1|root,COG0099@1|root,COG0100@1|root,COG0200@1|root,COG0522@1|root,KOG0408@2759|Eukaryota,KOG0846@2759|Eukaryota,KOG0877@2759|Eukaryota,KOG3254@2759|Eukaryota,KOG3301@2759|Eukaryota,KOG3311@2759|Eukaryota,3A0A4@33154|Opisthokonta,3BPCP@33208|Metazoa,3D14Y@33213|Bilateria,40D5S@6231|Nematoda,1KVYK@119089|Chromadorea,40TQD@6236|Rhabditida 33208|Metazoa J Ribosomal protein S11 MRPS11 GO:0000028,GO:0000313,GO:0000314,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006414,GO:0006415,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0019866,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032543,GO:0032984,GO:0032991,GO:0033554,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0042769,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0050896,GO:0051606,GO:0051716,GO:0065003,GO:0070013,GO:0070125,GO:0070126,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0098798,GO:0140053,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_262344_10 1168289.AJKI01000011_gene504 1.5e-07 63.2 COG3291@1|root,COG3291@2|Bacteria,4PHVT@976|Bacteroidetes,2FUHU@200643|Bacteroidia,3XIYY@558415|Marinilabiliaceae 976|Bacteroidetes S PKD domain - - - - - - - - - - - - CHU_C,PKD k59_262344_11 269797.Mbar_A1800 1.43e-20 102.0 COG1520@1|root,COG3291@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02482@2157|Archaea,arCOG02510@2157|Archaea,arCOG02550@2157|Archaea,arCOG03991@2157|Archaea,2XUI1@28890|Euryarchaeota,2NBKW@224756|Methanomicrobia 2157|Archaea S Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - CARDB,CBM_6,DUF3344,NosD,PKD,PQQ_2,PQQ_3,Pkinase k59_916308_1 1049564.TevJSym_ao00370 5.35e-101 303.0 COG0720@1|root,COG0720@2|Bacteria,1MXVT@1224|Proteobacteria,1RN6H@1236|Gammaproteobacteria,1J648@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H 6-pyruvoyl tetrahydropterin synthase SO2179 - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - PTPS k59_916308_2 1049564.TevJSym_aj00200 9.45e-190 538.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1J4SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_916308_3 1049564.TevJSym_aj00210 0.0 1326.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1J56C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_916308_4 435908.IDSA_00450 1.02e-48 171.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,2QFD2@267893|Idiomarinaceae 1236|Gammaproteobacteria M membrane - - - - - - - - - - - - Peptidase_M23 k59_916308_5 243233.MCA2421 1.6e-06 52.8 COG4701@1|root,COG4701@2|Bacteria,1NHRC@1224|Proteobacteria,1SDJY@1236|Gammaproteobacteria,1XFP6@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 k59_916308_6 1049564.TevJSym_aj00230 2.02e-181 509.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1J54C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_916308_7 713586.KB900536_gene1367 4.53e-185 525.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales 135613|Chromatiales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_916308_8 1335757.SPICUR_07610 3.67e-241 669.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales 135613|Chromatiales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_916308_9 472759.Nhal_0494 9.83e-55 184.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1X2GI@135613|Chromatiales 135613|Chromatiales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_916308_10 765913.ThidrDRAFT_1633 2.37e-145 418.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales 135613|Chromatiales M Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_916308_11 1049564.TevJSym_aj00280 2.45e-128 374.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1J4D5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_916308_12 1049564.TevJSym_aj00290 1.27e-190 542.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1J4RF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_524130_1 717774.Marme_3487 1.28e-53 170.0 COG4737@1|root,COG4737@2|Bacteria,1NAIM@1224|Proteobacteria,1SAPB@1236|Gammaproteobacteria,1XKQ4@135619|Oceanospirillales 135619|Oceanospirillales S RelE toxin of RelE / RelB toxin-antitoxin system - - - - - - - - - - - - RelE k59_524130_2 313606.M23134_01874 4.28e-06 48.5 COG0546@1|root,COG0546@2|Bacteria,4NPRI@976|Bacteroidetes 976|Bacteroidetes S HAD-hyrolase-like - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_164583_1 436114.SYO3AOP1_1033 4.35e-44 158.0 COG0119@1|root,COG0119@2|Bacteria,2G3JA@200783|Aquificae 200783|Aquificae E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_164583_2 553217.ENHAE0001_2114 2.55e-09 57.8 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,3NKCG@468|Moraxellaceae 1236|Gammaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_981620_1 1469607.KK073768_gene1009 1.27e-42 156.0 COG3039@1|root,COG3039@2|Bacteria,1G3YX@1117|Cyanobacteria 1117|Cyanobacteria L COG3039 Transposase and inactivated derivatives, IS5 family - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_916313_1 96561.Dole_2701 2.82e-58 202.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MIS4@213118|Desulfobacterales 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC ctpF - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_262352_2 709032.Sulku_1516 1.53e-26 106.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42NSY@68525|delta/epsilon subdivisions,2YNJN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP - - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_524139_1 224324.aq_1798 3.59e-19 89.4 COG0491@1|root,COG0491@2|Bacteria,2G4R1@200783|Aquificae 200783|Aquificae S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_720244_1 598659.NAMH_0989 1.35e-66 214.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2YN4Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_720244_2 929558.SMGD1_2482 2.46e-43 146.0 COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2YQ4W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM amino acid-binding ACT domain protein - - - - - - - - - - - - ACT k59_811_1 397290.C810_02110 6.45e-87 270.0 COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,27JB9@186928|unclassified Lachnospiraceae 186801|Clostridia S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_589517_1 1123400.KB904750_gene664 6.71e-08 52.8 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins iscR - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_687559_1 926550.CLDAP_35600 4.2e-83 259.0 COG1653@1|root,COG1653@2|Bacteria,2G8XC@200795|Chloroflexi 200795|Chloroflexi G COGs COG1653 ABC-type sugar transport system periplasmic component - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 k59_262360_2 563040.Saut_1382 5.12e-41 140.0 2AIVI@1|root,30TB8@2|Bacteria,1PD2X@1224|Proteobacteria,42TB3@68525|delta/epsilon subdivisions,2YPG6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_33724_1 1321778.HMPREF1982_01428 3.45e-53 179.0 COG1349@1|root,COG1349@2|Bacteria,1UDSK@1239|Firmicutes,24C0M@186801|Clostridia 186801|Clostridia K transcriptional regulator DeoR family - - - - - - - - - - - - DeoRC,HTH_DeoR k59_366931_2 765913.ThidrDRAFT_1741 2.63e-51 162.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1WYHJ@135613|Chromatiales 135613|Chromatiales J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_334628_1 944547.ABLL_0539 8.21e-87 279.0 COG2010@1|root,COG2010@2|Bacteria,1NG71@1224|Proteobacteria,42P5C@68525|delta/epsilon subdivisions,2YNRE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_889042_1 572544.Ilyop_0592 1.24e-137 401.0 COG0154@1|root,COG0154@2|Bacteria,3783S@32066|Fusobacteria 32066|Fusobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_758453_1 1294143.H681_21025 2.46e-10 62.8 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1RZ5Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane protein (homolog of Drosophila rhomboid) - - - - - - - - - - - - Rhomboid k59_758453_2 313606.M23134_01137 1.56e-07 52.8 COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,47P5J@768503|Cytophagia 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_138494_1 29730.Gorai.001G177200.1 8.23e-60 186.0 COG0852@1|root,KOG1713@2759|Eukaryota,37QGD@33090|Viridiplantae,3GGF5@35493|Streptophyta 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhJ GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0006950,GO:0007154,GO:0008137,GO:0008150,GO:0008152,GO:0009267,GO:0009507,GO:0009536,GO:0009605,GO:0009970,GO:0009987,GO:0009991,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0050896,GO:0051716,GO:0055114,GO:0071496 1.6.5.3 ko:K05581 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Complex1_30kDa,Oxidored_q6 k59_138494_2 4155.Migut.D01428.1.p 3e-144 410.0 COG0377@1|root,KOG1687@2759|Eukaryota,37QTD@33090|Viridiplantae,3GHED@35493|Streptophyta,44RGU@71274|asterids 35493|Streptophyta C NADH ubiquinone oxidoreductase, 20 Kd subunit ndhK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.6.5.3 ko:K05582 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_q6 k59_138494_3 981085.XP_010109401.1 7.33e-28 101.0 COG0838@1|root,KOG4662@2759|Eukaryota,37UN0@33090|Viridiplantae,3GISB@35493|Streptophyta,4JUVD@91835|fabids 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008137,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0015979,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K05574 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_q4 k59_987767_1 1408473.JHXO01000010_gene3623 7.37e-66 211.0 COG3301@1|root,COG3301@2|Bacteria,4NITJ@976|Bacteroidetes 976|Bacteroidetes P Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_824327_1 1168034.FH5T_21785 1.44e-30 110.0 COG2919@1|root,COG2919@2|Bacteria,4NURQ@976|Bacteroidetes 976|Bacteroidetes D Septum formation initiator - - - - - - - - - - - - DivIC k59_726510_1 1121918.ARWE01000001_gene3105 1.8e-110 346.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_629074_1 1121405.dsmv_1537 5.48e-40 145.0 COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MJD6@213118|Desulfobacterales 28221|Deltaproteobacteria C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k59_629074_2 177437.HRM2_40610 3.03e-41 142.0 COG1418@1|root,COG1418@2|Bacteria,1R60M@1224|Proteobacteria,42NFJ@68525|delta/epsilon subdivisions,2WIJT@28221|Deltaproteobacteria,2MJ3J@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM metal-dependent phosphohydrolase HD sub - - - - - - - - - - - - HD k59_596025_1 573413.Spirs_3480 4.22e-29 122.0 COG0840@1|root,COG0840@2|Bacteria,2J6A4@203691|Spirochaetes 203691|Spirochaetes NT methyl-accepting chemotaxis protein mcp-5 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_889732_1 944547.ABLL_1447 7.75e-99 304.0 COG0348@1|root,COG0348@2|Bacteria,1PYK0@1224|Proteobacteria,42Y5A@68525|delta/epsilon subdivisions,2YRHT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 k59_889732_2 1499685.CCFJ01000014_gene1456 2.78e-19 97.1 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1ZAVY@1386|Bacillus 91061|Bacilli T Diguanylate cyclase - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GAF_2,GGDEF,MASE3,PAS,PAS_9 k59_367642_2 742727.HMPREF9447_05290 1.42e-12 70.1 COG3654@1|root,COG3943@1|root,COG3654@2|Bacteria,COG3943@2|Bacteria,4NEGN@976|Bacteroidetes,2FQB8@200643|Bacteroidia,4APN9@815|Bacteroidaceae 976|Bacteroidetes S Virulence protein RhuM family - - - - - - - - - - - - Fic,Virulence_RhuM k59_889736_1 1122986.KB908321_gene1250 9.94e-21 93.6 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_889736_2 760192.Halhy_1380 2.37e-12 68.6 COG2133@1|root,COG3391@1|root,COG3511@1|root,COG2133@2|Bacteria,COG3391@2|Bacteria,COG3511@2|Bacteria,4NEFM@976|Bacteroidetes,1IVVM@117747|Sphingobacteriia 976|Bacteroidetes M Phosphoesterase family - - - - - - - - - - - - Phosphoesterase k59_923550_1 1123354.AUDR01000015_gene442 4.46e-52 179.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,1KS7T@119069|Hydrogenophilales 119069|Hydrogenophilales O Bacterial membrane protein N terminal - - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_857401_1 1537917.JU82_10945 2.61e-133 392.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2YNBN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_399895_1 931276.Cspa_c40780 8.21e-143 420.0 COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,36F7N@31979|Clostridiaceae 186801|Clostridia C Belongs to the NiFe NiFeSe hydrogenase large subunit family hupL - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_399895_2 1120985.AUMI01000015_gene1718 2.49e-21 91.7 COG0680@1|root,COG0680@2|Bacteria,1V7KQ@1239|Firmicutes,4H4NS@909932|Negativicutes 909932|Negativicutes C hydrogenase expression formation protein hybD - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_399895_3 1407650.BAUB01000006_gene1485 6e-18 80.1 COG0375@1|root,COG0375@2|Bacteria,1G89Y@1117|Cyanobacteria,1H1N4@1129|Synechococcus 1117|Cyanobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_399895_4 1487921.DP68_01155 8.03e-99 293.0 COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia,36E69@31979|Clostridiaceae 186801|Clostridia KO Hydrogenase accessory protein HypB ureG - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_399895_5 1280390.CBQR020000147_gene3826 1.78e-12 63.9 COG1826@1|root,COG1826@2|Bacteria,1VFP2@1239|Firmicutes,4HNM7@91061|Bacilli,26ZSU@186822|Paenibacillaceae 91061|Bacilli U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_399895_6 1047013.AQSP01000099_gene1495 4.02e-32 125.0 COG0805@1|root,COG0805@2|Bacteria,2NPGB@2323|unclassified Bacteria 2|Bacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_399895_7 1410653.JHVC01000003_gene3974 3.88e-21 93.2 COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,36EAU@31979|Clostridiaceae 186801|Clostridia O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_988485_1 1121904.ARBP01000042_gene4910 1.03e-28 125.0 COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,47M35@768503|Cytophagia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_39275_1 1319815.HMPREF0202_01413 2.73e-17 76.6 COG0756@1|root,COG0756@2|Bacteria,37A2G@32066|Fusobacteria 32066|Fusobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_39275_2 572544.Ilyop_1136 1.5e-309 863.0 COG0209@1|root,COG0209@2|Bacteria,378A9@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC k59_236545_1 367737.Abu_2028 2.99e-118 364.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,42M8I@68525|delta/epsilon subdivisions,2YN4J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 k59_367657_1 1168034.FH5T_19750 2.99e-121 359.0 COG0527@1|root,COG0527@2|Bacteria,4PKFA@976|Bacteroidetes,2G3F2@200643|Bacteroidia 976|Bacteroidetes E Amino acid kinase family - - 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_726537_1 1045856.EcWSU1_00127 1.18e-86 272.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,3X0ID@547|Enterobacter 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_923562_2 1168034.FH5T_08405 7.72e-32 112.0 2EG8Z@1|root,33A0S@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_106512_1 207559.Dde_3424 1.03e-55 192.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42M86@68525|delta/epsilon subdivisions,2WIT1@28221|Deltaproteobacteria,2M8F1@213115|Desulfovibrionales 28221|Deltaproteobacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_106512_2 481448.Minf_0320 5.74e-22 95.5 COG1743@1|root,COG1743@2|Bacteria,46W8J@74201|Verrucomicrobia 74201|Verrucomicrobia H DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_301278_1 1408439.JHXW01000003_gene1542 6.41e-121 353.0 COG2070@1|root,COG2070@2|Bacteria,3789E@32066|Fusobacteria 32066|Fusobacteria S Nitronate monooxygenase - - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_301278_2 1121121.KB894290_gene1862 1.8e-129 380.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4HATK@91061|Bacilli,26QJP@186822|Paenibacillaceae 91061|Bacilli I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_301278_3 572544.Ilyop_1512 1.81e-19 86.7 COG0416@1|root,COG0416@2|Bacteria,3791E@32066|Fusobacteria 32066|Fusobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_268452_1 350058.Mvan_3505 3.12e-22 100.0 COG2730@1|root,COG3469@1|root,COG2730@2|Bacteria,COG3469@2|Bacteria,2GJTU@201174|Actinobacteria,2384A@1762|Mycobacteriaceae 201174|Actinobacteria G Belongs to the glycosyl hydrolase 18 family chiA2 - 3.2.1.14,3.2.1.4 ko:K01179,ko:K01183 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R01206,R02334,R06200,R11307,R11308 RC00467 ko00000,ko00001,ko01000 - GH18,GH5,GH9 - CBM_2,CBM_4_9,Glyco_hydro_18,Ricin_B_lectin,fn3 k59_399915_1 1049564.TevJSym_bn00120 3.45e-60 190.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1JAMF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosyl transferase domain pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_399915_2 76114.ebA1756 5.36e-05 45.4 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2VUH0@28216|Betaproteobacteria,2KWP7@206389|Rhodocyclales 206389|Rhodocyclales J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_629114_1 484770.UFO1_0163 2.26e-169 486.0 COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,4H2AQ@909932|Negativicutes 909932|Negativicutes G glucuronate isomerase uxaC - 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - - UxaC k59_629114_2 526218.Sterm_0701 4.92e-47 163.0 COG0246@1|root,COG0246@2|Bacteria,379RH@32066|Fusobacteria 32066|Fusobacteria G Mannitol dehydrogenase Rossmann domain - - 1.1.1.58 ko:K00041 ko00040,ko01100,map00040,map01100 M00631 R02555 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_139225_1 4572.TRIUR3_00083-P1 5.37e-102 312.0 28Q3A@1|root,2QWRZ@2759|Eukaryota,37IKA@33090|Viridiplantae,3GANT@35493|Streptophyta,3KWRZ@4447|Liliopsida,3IFBD@38820|Poales 35493|Streptophyta J Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns matK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - ko:K20000 - - - - ko00000,ko03016 - - - Intron_maturas2,MatK_N k59_399917_1 316067.Geob_0131 1.12e-27 110.0 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,42TV7@68525|delta/epsilon subdivisions,2WRW0@28221|Deltaproteobacteria,43TY1@69541|Desulfuromonadales 28221|Deltaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - TPR_6,YkuD k59_662090_1 414684.RC1_0760 6.61e-36 126.0 COG1522@1|root,COG1522@2|Bacteria,1RI7R@1224|Proteobacteria,2U9CC@28211|Alphaproteobacteria,2JTN8@204441|Rhodospirillales 204441|Rhodospirillales K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_24 k59_662090_2 715226.ABI_46200 1.96e-05 50.8 COG3577@1|root,COG3577@2|Bacteria,1MYAD@1224|Proteobacteria,2UDTN@28211|Alphaproteobacteria,2KH1B@204458|Caulobacterales 204458|Caulobacterales S gag-polyprotein putative aspartyl protease - - - - - - - - - - - - Asp_protease_2 k59_726551_1 1163407.UU7_07173 2.1e-67 214.0 2A5P5@1|root,30UDZ@2|Bacteria,1RHAP@1224|Proteobacteria,1SXHY@1236|Gammaproteobacteria,1X69H@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_923574_1 1122185.N792_06140 5.05e-78 243.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1X3RU@135614|Xanthomonadales 135614|Xanthomonadales E lysine 2,3-aminomutase - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM k59_596073_1 706587.Desti_5586 2.63e-62 197.0 COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WJJB@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Methylene-tetrahydrofolate reductase C terminal - - - - - - - - - - - - MTHFR_C k59_596073_2 1232437.KL662031_gene2576 4.19e-07 50.4 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,2MJC0@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Methylenetetrahydrofolate reductase - - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - CdhD,MTHFR k59_335422_1 572544.Ilyop_0757 1.73e-87 270.0 COG1295@1|root,COG1295@2|Bacteria,3787Z@32066|Fusobacteria 32066|Fusobacteria K Psort location CytoplasmicMembrane, score 10.00 - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_694263_1 768671.ThimaDRAFT_4797 1.51e-116 353.0 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1WWX7@135613|Chromatiales 135613|Chromatiales U Type II secretory pathway component ExeA - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_301297_1 1191523.MROS_0573 1.18e-44 151.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_C_10,TetR_N k59_399924_1 1033802.SSPSH_003367 2.45e-79 253.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the pyruvate kinase family pykA GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740 PK,PK_C k59_399924_2 1485545.JQLW01000009_gene47 3.03e-89 274.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria 1224|Proteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSbBS512_1146.SbBS512_E3351 PGK k59_106540_1 1249627.D779_3727 3.64e-81 253.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales 135613|Chromatiales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_923578_1 1321779.HMPREF1984_01795 3.35e-06 47.8 COG0050@1|root,COG0050@2|Bacteria,3784P@32066|Fusobacteria 32066|Fusobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_923578_2 572544.Ilyop_1811 3.52e-57 178.0 COG0051@1|root,COG0051@2|Bacteria,37AGY@32066|Fusobacteria 32066|Fusobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_923578_3 572544.Ilyop_1810 1.3e-123 355.0 COG0087@1|root,COG0087@2|Bacteria,3783B@32066|Fusobacteria 32066|Fusobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_923578_4 572544.Ilyop_1809 1.13e-116 337.0 COG0088@1|root,COG0088@2|Bacteria,379E3@32066|Fusobacteria 32066|Fusobacteria J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_923578_5 1319815.HMPREF0202_01267 1.23e-42 141.0 COG0089@1|root,COG0089@2|Bacteria,37AUM@32066|Fusobacteria 32066|Fusobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_923578_6 190304.FN1642 1.89e-88 266.0 COG0090@1|root,COG0090@2|Bacteria,379DG@32066|Fusobacteria 32066|Fusobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_662103_1 491915.Aflv_2449 1.06e-93 285.0 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,4HDK4@91061|Bacilli 91061|Bacilli L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_662103_2 1003195.SCAT_1376 2.04e-05 47.0 COG2963@1|root,COG2963@2|Bacteria,2IQ8F@201174|Actinobacteria 201174|Actinobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_629146_1 1249480.B649_07770 1.01e-39 144.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2YMFX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N_3 k59_629146_2 697282.Mettu_1623 7.81e-67 216.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XEFM@135618|Methylococcales 135618|Methylococcales H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_791126_1 571.MC52_09110 8.83e-171 501.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold nfdA_2 - - - - - - - - - - - Amidohydro_3 k59_563908_2 929558.SMGD1_0097 7.88e-39 132.0 2BQJ4@1|root,32JEZ@2|Bacteria,1Q29Y@1224|Proteobacteria,42V8X@68525|delta/epsilon subdivisions,2YQIT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_335444_1 1305737.JAFX01000001_gene3128 1.18e-54 185.0 COG0624@1|root,COG0624@2|Bacteria,4NJEK@976|Bacteroidetes,47N41@768503|Cytophagia 976|Bacteroidetes E Peptidase family M20/M25/M40 - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_73460_2 1410619.SRDD_17490 9.04e-27 111.0 COG2213@1|root,COG4668@1|root,COG2213@2|Bacteria,COG4668@2|Bacteria,1MUPU@1224|Proteobacteria,1RNAG@1236|Gammaproteobacteria,4004K@613|Serratia 1236|Gammaproteobacteria G catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane mtlA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015166,GO:0015318,GO:0015575,GO:0015791,GO:0015797,GO:0015850,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090565,GO:1901618 2.7.1.197 ko:K02798,ko:K02799,ko:K02800 ko00051,ko02060,map00051,map02060 M00274 R02704 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5 - iAPECO1_1312.APECO1_2858,iEC042_1314.EC042_3906,iECIAI39_1322.ECIAI39_4114,iECOK1_1307.ECOK1_4040,iECS88_1305.ECS88_4012,iECUMN_1333.ECUMN_4110,iUMN146_1321.UM146_18140,iUTI89_1310.UTI89_C4137 PTS_EIIA_2,PTS_EIIC,PTS_IIB k59_629160_1 396588.Tgr7_2396 4.82e-32 127.0 COG1716@1|root,COG3267@1|root,COG1716@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1WWX7@135613|Chromatiales 135613|Chromatiales U Type II secretory pathway component ExeA - - - ko:K02450,ko:K12283 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22 k59_367712_1 572544.Ilyop_0750 1.04e-15 77.0 COG2188@1|root,COG2188@2|Bacteria,37A4Y@32066|Fusobacteria 32066|Fusobacteria K PFAM UbiC transcription regulator-associated domain protein - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k59_73465_2 1463900.JOIX01000058_gene1551 5.42e-05 47.4 COG0406@1|root,COG0406@2|Bacteria,2I9GN@201174|Actinobacteria 201174|Actinobacteria G phosphoglycerate mutase - - 3.1.3.85,5.4.2.12 ko:K15634,ko:K22306 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_79197_8 572477.Alvin_2711 7.42e-271 763.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1WWEX@135613|Chromatiales 135613|Chromatiales S PFAM ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_79197_9 1123020.AUIE01000003_gene466 1.19e-06 56.6 COG0515@1|root,COG0515@2|Bacteria,1RAG3@1224|Proteobacteria,1SZS9@1236|Gammaproteobacteria,1YDJ4@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria KLT Lipopolysaccharide kinase (Kdo/WaaP) family - - - - - - - - - - - - Kdo k59_79197_11 1049564.TevJSym_at00540 4.81e-193 543.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1J50S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein, ATPase PilU uptC - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_79197_12 765912.Thimo_0103 0.0 1229.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WVYX@135613|Chromatiales 135613|Chromatiales G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_79197_13 237368.SCABRO_02305 1.4e-42 160.0 COG2206@1|root,COG2206@2|Bacteria,2J3D3@203682|Planctomycetes 203682|Planctomycetes T signal transduction HD GYP protein - - - - - - - - - - - - HD,HD_5 k59_79197_14 1049564.TevJSym_ag00510 7.3e-107 317.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1J4SR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_79197_15 1049564.TevJSym_ag00550 4.79e-32 114.0 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SD3Y@1236|Gammaproteobacteria,1J6YA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_79197_17 1121374.KB891576_gene773 8.21e-51 189.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVK@1236|Gammaproteobacteria 1236|Gammaproteobacteria D PFAM Sulphatase-modifying factor - - - ko:K20333 ko02024,map02024 - - - ko00000,ko00001 - - - FGE-sulfatase,Pkinase k59_79197_18 768671.ThimaDRAFT_1447 9.17e-181 525.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1SMH6@1236|Gammaproteobacteria,1X0JB@135613|Chromatiales 135613|Chromatiales E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_79197_19 1042876.PPS_4756 8.7e-41 142.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S60F@1236|Gammaproteobacteria,1YYGY@136845|Pseudomonas putida group 1236|Gammaproteobacteria S gag-polyprotein putative aspartyl protease orf - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_668756_1 247634.GPB2148_950 5.8e-119 358.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1J5CM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_700408_1 1117647.M5M_04685 3.33e-11 67.4 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1J6WD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat-like domain yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_961860_1 360104.CCC13826_0806 3.5e-25 95.9 COG4679@1|root,COG4679@2|Bacteria,1MZ3N@1224|Proteobacteria,42U5T@68525|delta/epsilon subdivisions 1224|Proteobacteria S Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 k59_961860_2 360104.CCC13826_0807 4.6e-26 99.4 COG1396@1|root,COG1396@2|Bacteria,1QWDJ@1224|Proteobacteria,42VA9@68525|delta/epsilon subdivisions,2YQCH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_765551_1 439235.Dalk_3080 1.96e-47 158.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,2MJMY@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_831103_1 1168034.FH5T_11730 5.32e-91 276.0 COG0337@1|root,COG0337@2|Bacteria,4NGSS@976|Bacteroidetes,2FNVM@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_210896_1 1168034.FH5T_02000 2.63e-48 167.0 COG2942@1|root,COG2942@2|Bacteria,4NEH7@976|Bacteroidetes,2FM9N@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) bfce - 5.1.3.11 ko:K16213 - - R01445,R10810 RC00289 ko00000,ko01000 - - - GlcNAc_2-epim k59_668770_1 1121405.dsmv_0624 1.04e-77 242.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,42P1T@68525|delta/epsilon subdivisions,2WKZB@28221|Deltaproteobacteria,2MI0P@213118|Desulfobacterales 28221|Deltaproteobacteria F TIGRFAM deoxyguanosinetriphosphate triphosphohydrolase - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_863262_1 1168034.FH5T_08895 2.83e-86 260.0 COG3828@1|root,COG3828@2|Bacteria,4NFYI@976|Bacteroidetes,2G2RZ@200643|Bacteroidia 976|Bacteroidetes CG Trehalose utilisation - - - ko:K09992 - - - - ko00000 - - - CARDB,Copper-bind,ThuA k59_505818_1 1260251.SPISAL_00960 1.72e-32 119.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1WWGA@135613|Chromatiales 135613|Chromatiales P TIGRFAM Molybdate ABC transporter - - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_112170_1 207559.Dde_2310 1.37e-28 104.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,42SJJ@68525|delta/epsilon subdivisions,2WP4E@28221|Deltaproteobacteria,2MBZ0@213115|Desulfovibrionales 28221|Deltaproteobacteria K Belongs to the P(II) protein family glnB-1 - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_863268_1 266265.Bxe_A0277 2.33e-59 194.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,1K233@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh k59_537975_2 526218.Sterm_1014 2.73e-117 348.0 COG2073@1|root,COG2073@2|Bacteria,378UN@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score 8.96 - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid k59_146016_1 929558.SMGD1_0378 7.89e-77 261.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2YMB9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T chemotaxis protein cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_210913_1 1396141.BATP01000001_gene5330 1.97e-74 244.0 28HMZ@1|root,2Z7WD@2|Bacteria,46TFX@74201|Verrucomicrobia,2IVCD@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_178474_1 452652.KSE_22420 6.86e-17 84.3 COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,2M2M0@2063|Kitasatospora 201174|Actinobacteria L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_146018_3 218851.Aquca_023_00090.1 1.7e-15 80.1 28ZYQ@1|root,2R6TI@2759|Eukaryota,37R3C@33090|Viridiplantae,3GH9I@35493|Streptophyta 35493|Streptophyta L DNA-directed DNA polymerase activity - - - - - - - - - - - - DNA_pol_B_2 k59_995136_2 546275.FUSPEROL_01396 8.37e-05 54.7 COG3210@1|root,COG3210@2|Bacteria,379BK@32066|Fusobacteria 32066|Fusobacteria U domain, Protein - - - - - - - - - - - - Autotransporter k59_537983_1 869213.JCM21142_62446 9.43e-60 205.0 COG4677@1|root,COG4733@1|root,COG4677@2|Bacteria,COG4733@2|Bacteria,4NEEI@976|Bacteroidetes,47M0T@768503|Cytophagia 976|Bacteroidetes G Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pectinesterase k59_112180_1 65093.PCC7418_3230 4.8e-15 81.6 COG1523@1|root,COG1523@2|Bacteria,1G1EG@1117|Cyanobacteria 1117|Cyanobacteria G Domain of unknown function (DUF3372) - - - - - - - - - - - - CBM_48,DUF3372 k59_1026675_1 945713.IALB_0943 2.82e-45 160.0 COG1015@1|root,COG1015@2|Bacteria 2|Bacteria G phosphopentomutase activity deoB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165 Metalloenzyme k59_112187_1 1158756.AQXQ01000009_gene1193 6.77e-113 339.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1WWC6@135613|Chromatiales 135613|Chromatiales M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_961885_1 1408439.JHXW01000013_gene1073 2.27e-82 264.0 COG0826@1|root,COG0826@2|Bacteria,3791B@32066|Fusobacteria 32066|Fusobacteria O Psort location Cytoplasmic, score 8.96 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 k59_961885_2 1444310.JANV01000124_gene2938 7.72e-29 122.0 COG0371@1|root,COG0371@2|Bacteria,1TQFU@1239|Firmicutes,4HC8K@91061|Bacilli,1ZDR5@1386|Bacillus 91061|Bacilli C COG0371 Glycerol dehydrogenase and related enzymes ypjH - - ko:K08317 - - - - ko00000,ko01000 - - - Fe-ADH k59_961885_3 572479.Hprae_1491 7.34e-135 399.0 COG0025@1|root,COG0025@2|Bacteria,1UHUI@1239|Firmicutes,25E2Y@186801|Clostridia 186801|Clostridia P Transporter, CPA2 family - - - - - - - - - - - - Na_H_Exchanger k59_961885_4 1196031.ALEG01000064_gene3626 2.2e-44 153.0 COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,1ZFSI@1386|Bacillus 91061|Bacilli F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08510 CoaE k59_505852_1 426368.MmarC7_1594 1.1e-45 156.0 COG0500@1|root,arCOG01786@2157|Archaea,2XYF4@28890|Euryarchaeota 28890|Euryarchaeota Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_438134_1 765420.OSCT_0473 1.89e-148 441.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G5QP@200795|Chloroflexi,3770F@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_273971_1 1485544.JQKP01000001_gene889 7.35e-34 136.0 COG3203@1|root,COG3203@2|Bacteria,1RH1J@1224|Proteobacteria,2WGFH@28216|Betaproteobacteria,44WPI@713636|Nitrosomonadales 28216|Betaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_995157_1 749222.Nitsa_0338 1.38e-63 199.0 COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,42RGX@68525|delta/epsilon subdivisions,2YPA8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TIGRFAM DJ-1 family protein thiJ - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_995157_2 387093.SUN_0556 4.47e-54 173.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2YM7S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_146043_2 1173029.JH980292_gene1414 2e-61 195.0 COG4122@1|root,COG4122@2|Bacteria,1G2Y6@1117|Cyanobacteria,1H74J@1150|Oscillatoriales 1117|Cyanobacteria S PFAM O-methyltransferase - - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 k59_603188_1 1168034.FH5T_03865 2.25e-125 389.0 COG2352@1|root,COG2352@2|Bacteria,4NFC0@976|Bacteroidetes,2FSEF@200643|Bacteroidia 976|Bacteroidetes C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_210966_1 1151127.KB906326_gene53 6.53e-66 213.0 COG2227@1|root,COG2227@2|Bacteria,1MWY9@1224|Proteobacteria,1TCHF@1236|Gammaproteobacteria,1YNMG@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria H C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_14,Methyltransf_23 k59_210966_2 640081.Dsui_0067 4.99e-126 365.0 COG3510@1|root,COG3510@2|Bacteria,1MWJ8@1224|Proteobacteria,2WA6U@28216|Betaproteobacteria,2KZJY@206389|Rhodocyclales 206389|Rhodocyclales V Cephalosporin hydroxylase - - - - - - - - - - - - CmcI k59_732095_1 525898.Sdel_1501 1.97e-160 483.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,43BP0@68525|delta/epsilon subdivisions,2YTEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LV TaqI-like C-terminal specificity domain - - - - - - - - - - - - N6_Mtase,TaqI_C k59_538026_2 1397527.Q670_02310 6.28e-07 50.8 COG0517@1|root,COG0517@2|Bacteria,1N2TU@1224|Proteobacteria,1S9T1@1236|Gammaproteobacteria,1XRFP@135619|Oceanospirillales 135619|Oceanospirillales S COG0517 FOG CBS domain - - - - - - - - - - - - CBS k59_438163_1 187303.BN69_2478 3.92e-38 143.0 COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2TQRV@28211|Alphaproteobacteria,36Y60@31993|Methylocystaceae 28211|Alphaproteobacteria S CHAD - - - - - - - - - - - - CHAD,CYTH k59_765635_1 1168034.FH5T_16455 6.59e-87 278.0 COG0072@1|root,COG0072@2|Bacteria,4NF5B@976|Bacteroidetes,2FNBF@200643|Bacteroidia 976|Bacteroidetes J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_112212_1 859657.RPSI07_2292 1.92e-119 382.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria,1K20Q@119060|Burkholderiaceae 28216|Betaproteobacteria E NAD-glutamate dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_438982_2 1122604.JONR01000030_gene1314 2.08e-27 103.0 COG3686@1|root,COG3686@2|Bacteria,1MZP7@1224|Proteobacteria,1SADS@1236|Gammaproteobacteria,1X806@135614|Xanthomonadales 135614|Xanthomonadales S MAPEG family - - - - - - - - - - - - MAPEG k59_80070_1 762903.Pedsa_0610 1.37e-44 153.0 COG0463@1|root,COG0463@2|Bacteria,4NEVT@976|Bacteroidetes,1IPAW@117747|Sphingobacteriia 976|Bacteroidetes M glycosyl transferase family 2 arnC - - - - - - - - - - - Glycos_transf_2 k59_80070_2 1349785.BAUG01000012_gene1018 1.46e-10 62.0 2DM6B@1|root,31WK9@2|Bacteria,4NQK1@976|Bacteroidetes,1I2ZA@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF4199) - - - - - - - - - - - - DUF4199 k59_897294_2 1049564.TevJSym_ad00110 5.33e-199 556.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1J559@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSSON_1240.SSON_1444,iYL1228.KPN_02176 Phe_tRNA-synt_N,tRNA-synt_2d k59_897294_3 1049564.TevJSym_ad00120 0.0 1042.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_897294_5 1249627.D779_3759 1.43e-60 188.0 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,1S6Y1@1236|Gammaproteobacteria,1WYCP@135613|Chromatiales 135613|Chromatiales K PFAM regulatory protein, MerR - - - - - - - - - - - - MerR_1 k59_45712_1 1121396.KB893001_gene3993 1.06e-28 118.0 COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,42N70@68525|delta/epsilon subdivisions,2WR7I@28221|Deltaproteobacteria,2MM57@213118|Desulfobacterales 28221|Deltaproteobacteria U Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - - - - - - - - - - POTRA_2,ShlB k59_930853_1 552811.Dehly_0447 1.45e-96 293.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia 301297|Dehalococcoidia L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_930853_2 552811.Dehly_0278 7.53e-10 56.6 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_897306_1 563040.Saut_1066 3.77e-124 377.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43CE4@68525|delta/epsilon subdivisions,2YTBQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM EAL domain - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_995997_1 318996.AXAZ01000010_gene5546 4.91e-113 336.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,3JTT2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G pfkB family carbohydrate kinase pfkB - 2.7.1.20,2.7.1.4 ko:K00847,ko:K00856 ko00051,ko00230,ko00500,ko00520,ko01100,map00051,map00230,map00500,map00520,map01100 - R00185,R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_243422_1 387093.SUN_2223 3.92e-88 264.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,43B19@68525|delta/epsilon subdivisions,2YT52@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_701348_2 1125863.JAFN01000001_gene3064 2.61e-18 89.0 COG0407@1|root,COG0407@2|Bacteria,1MZ5P@1224|Proteobacteria,42TMK@68525|delta/epsilon subdivisions,2WR32@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_438991_2 1217705.F900_02105 1.9e-37 143.0 2DB8F@1|root,2Z7RQ@2|Bacteria,1NA57@1224|Proteobacteria,1RQ25@1236|Gammaproteobacteria,3NM3Z@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_795880_1 439235.Dalk_2933 3.48e-54 187.0 COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MHP3@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 k59_996011_1 519989.ECTPHS_06637 7.19e-24 107.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales 135613|Chromatiales M PFAM Lytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_538941_1 1408473.JHXO01000006_gene1237 1.06e-108 321.0 COG1082@1|root,COG1082@2|Bacteria,4NJ3Z@976|Bacteroidetes,2FX90@200643|Bacteroidia 976|Bacteroidetes G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_113048_1 1266845.Q783_06895 9.33e-90 277.0 COG0707@1|root,COG0707@2|Bacteria,1VC9P@1239|Firmicutes,4HN9C@91061|Bacilli,27H3Q@186828|Carnobacteriaceae 91061|Bacilli M Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C,Glyco_trans_1_3 k59_113048_3 926561.KB900618_gene233 9.02e-105 318.0 COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,24B2N@186801|Clostridia,3WB9Z@53433|Halanaerobiales 186801|Clostridia S Pfam:UPF0118 - - - - - - - - - - - - AI-2E_transport k59_113048_6 1042877.GQS_00110 1.25e-18 89.7 COG0631@1|root,arCOG05302@2157|Archaea,2XX93@28890|Euryarchaeota,243N4@183968|Thermococci 183968|Thermococci T Sigma factor PP2C-like phosphatases - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_732927_1 1123060.JONP01000016_gene5488 1.31e-67 223.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,2JPU2@204441|Rhodospirillales 204441|Rhodospirillales E ABC transporter, substrate-binding protein, family 5 - - - - - - - - - - - - SBP_bac_5 k59_185567_1 556263.FSEG_00069 2.7e-39 144.0 COG0859@1|root,COG0859@2|Bacteria,3786E@32066|Fusobacteria 32066|Fusobacteria M Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Glyco_transf_9 k59_185567_2 469617.FUAG_00359 1.4e-28 111.0 COG3642@1|root,COG3642@2|Bacteria,37CHU@32066|Fusobacteria 2|Bacteria T lipopolysaccharide core region biosynthetic process rfaY GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 - ko:K02850 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005 - - - Kdo,WaaY k59_903572_1 1089548.KI783301_gene2503 1.51e-19 92.4 COG3039@1|root,COG3039@2|Bacteria,1TS6Q@1239|Firmicutes,4HD8C@91061|Bacilli 91061|Bacilli L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_577173_1 1165841.SULAR_05243 3.14e-71 227.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2YN9H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Ammonium Transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_642714_2 247639.MGP2080_06282 2.09e-75 230.0 COG3516@1|root,COG3516@2|Bacteria,1RAZQ@1224|Proteobacteria,1RY42@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Type VI secretion sciH - - ko:K11901 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_VipA k59_642714_3 497964.CfE428DRAFT_2863 1.65e-15 77.4 COG3515@1|root,COG3515@2|Bacteria,46WW4@74201|Verrucomicrobia 74201|Verrucomicrobia S ImpA, N-terminal, type VI secretion system - - - - - - - - - - - - ImpA_N k59_412941_1 1499967.BAYZ01000118_gene3302 3.12e-68 216.0 COG0697@1|root,COG0697@2|Bacteria,2NRS8@2323|unclassified Bacteria 2|Bacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1002241_2 349124.Hhal_1725 2.35e-16 81.3 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales 135613|Chromatiales S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_349363_1 326298.Suden_0839 3.78e-19 80.9 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,42TWY@68525|delta/epsilon subdivisions,2YPX1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_349363_3 498211.CJA_2093 2.92e-18 90.1 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_51816_1 1268240.ATFI01000001_gene3276 3.5e-103 324.0 COG3345@1|root,COG3507@1|root,COG3345@2|Bacteria,COG3507@2|Bacteria,4PKXQ@976|Bacteroidetes,2FNWV@200643|Bacteroidia,4AMQ8@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family xynD_2 - 3.2.1.55 ko:K15921 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - CBM6,GH43 - CBM_6,Glyco_hydro_43 k59_903589_1 1485544.JQKP01000011_gene736 7.71e-29 118.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,44V2C@713636|Nitrosomonadales 28216|Betaproteobacteria I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_802114_1 748727.CLJU_c02840 1.74e-42 156.0 COG0441@1|root,COG0572@1|root,COG0441@2|Bacteria,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,36DT4@31979|Clostridiaceae 186801|Clostridia F uridine kinase udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK k59_119534_1 1297863.APJF01000025_gene2983 3.14e-75 250.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3JV04@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V Efflux pump membrane transporter - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_512981_1 1249627.D779_1500 3.49e-21 94.7 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVZ6@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_512981_2 1049564.TevJSym_ax00160 2.66e-46 158.0 COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,1J9DV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase sqr - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_478271_2 485915.Dret_1753 5.04e-13 64.7 COG0724@1|root,COG0724@2|Bacteria,1N0P8@1224|Proteobacteria,43B6G@68525|delta/epsilon subdivisions,2WQ1E@28221|Deltaproteobacteria,2MH3Y@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM RNP-1 like RNA-binding protein - - - - - - - - - - - - RRM_1 k59_642728_1 1173022.Cri9333_1511 1.5e-11 62.0 COG0614@1|root,COG0614@2|Bacteria,1G73G@1117|Cyanobacteria,1HFHX@1150|Oscillatoriales 1117|Cyanobacteria P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_642728_2 1279038.KB907338_gene979 0.0 877.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,2JQVU@204441|Rhodospirillales 204441|Rhodospirillales I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_839089_2 187272.Mlg_2624 1.32e-22 99.4 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_1034382_1 387093.SUN_1659 3.79e-48 174.0 COG0068@1|root,COG0068@2|Bacteria,1Q0S6@1224|Proteobacteria,42SF1@68525|delta/epsilon subdivisions,2YPJ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O HypF finger - - - - - - - - - - - - zf-HYPF k59_708412_1 1168034.FH5T_12605 9.7e-114 350.0 COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,4NGX5@976|Bacteroidetes,2FMKY@200643|Bacteroidia 976|Bacteroidetes C phosphate acetyltransferase pta - 2.3.1.8 ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,DRTGG,PTA_PTB k59_513844_1 1395587.P364_0119595 6.55e-102 331.0 COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4I2RT@91061|Bacilli,26UUG@186822|Paenibacillaceae 91061|Bacilli Q Belongs to the beta-ketoacyl-ACP synthases family - - - - - - - - - - - - KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt k59_186465_1 484018.BACPLE_01787 1.03e-07 52.8 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,2FN30@200643|Bacteroidia,4AKPU@815|Bacteroidaceae 976|Bacteroidetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrd - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_186465_2 745718.JADT01000021_gene2645 1.92e-21 91.3 COG3137@1|root,COG3137@2|Bacteria,4NGB2@976|Bacteroidetes,1HY5S@117743|Flavobacteriia 976|Bacteroidetes M Protein of unknown function (DUF3078) - - - - - - - - - - - - DUF3078 k59_610903_1 1249480.B649_05815 4.94e-99 300.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42NHA@68525|delta/epsilon subdivisions,2YMYU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX1 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_610904_1 398580.Dshi_2295 3.81e-22 96.7 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_250593_1 439235.Dalk_2485 4.44e-91 271.0 COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2MI9K@213118|Desulfobacterales 28221|Deltaproteobacteria S Gtr1/RagA G protein conserved region mglA GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - ko:K06883 - - - - ko00000 - - - Arf,Ras k59_479023_2 1565314.OA34_00580 2.17e-16 74.3 COG0735@1|root,COG0735@2|Bacteria,1PU7E@1224|Proteobacteria,42TR2@68525|delta/epsilon subdivisions,2YPVY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the Fur family - - - ko:K03711,ko:K09823 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - FUR k59_708417_1 472759.Nhal_3687 5.67e-137 403.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_676885_1 746697.Aeqsu_1901 1.93e-85 278.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1HWYV@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_446120_1 311402.Avi_3060 2.44e-10 62.4 COG4382@1|root,COG4382@2|Bacteria,1N8KH@1224|Proteobacteria,2UBCX@28211|Alphaproteobacteria,4BF2E@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1018) - - - - - - - - - - - - DUF1018 k59_937719_1 1172190.M947_02865 3.27e-94 285.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2YMW7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1034402_1 768671.ThimaDRAFT_3655 4.68e-69 230.0 COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1WW3V@135613|Chromatiales 135613|Chromatiales J Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA rlmL - 2.1.1.173,2.1.1.264 ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_871161_1 930166.CD58_01735 2.42e-29 117.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction histidine kinase, nitrogen specific glnL GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_52679_1 1122604.JONR01000004_gene890 1.36e-86 269.0 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria,1X80N@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_904458_1 879212.DespoDRAFT_03615 5.74e-05 50.1 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_1003092_1 589873.EP13_01415 2.01e-21 94.4 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,464X2@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23,HlyD_D4 k59_1003092_2 305900.GV64_09500 4.36e-14 75.1 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,1XHHM@135619|Oceanospirillales 135619|Oceanospirillales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_413649_2 906968.Trebr_1048 1.67e-24 103.0 COG0500@1|root,COG2226@2|Bacteria,2J8C7@203691|Spirochaetes 203691|Spirochaetes Q Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_413649_3 426368.MmarC7_1765 1.13e-108 318.0 COG2364@1|root,arCOG05100@2157|Archaea,2XY4B@28890|Euryarchaeota,23RG1@183939|Methanococci 183939|Methanococci - - - - - - - - - - - - - - - k59_413649_4 931626.Awo_c08590 9.15e-39 140.0 COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24HZR@186801|Clostridia,25ZEB@186806|Eubacteriaceae 186801|Clostridia S haloacid dehalogenase-like hydrolase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_839116_1 1168034.FH5T_09280 2.36e-71 218.0 COG2391@1|root,COG2391@2|Bacteria,4NGS1@976|Bacteroidetes 976|Bacteroidetes S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_839116_2 1265313.HRUBRA_00421 4.03e-05 46.6 COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,1S48Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_446134_1 1168034.FH5T_01100 4.45e-140 406.0 COG1228@1|root,COG1228@2|Bacteria,4NE6C@976|Bacteroidetes,2FNW2@200643|Bacteroidia 976|Bacteroidetes Q Imidazolone-5-propionate hydrolase hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_446134_2 1168034.FH5T_01095 2.91e-11 62.8 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia 976|Bacteroidetes E Glutamate formimidoyltransferase ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N k59_186493_1 1168034.FH5T_10090 6.5e-176 520.0 COG0458@1|root,COG0458@2|Bacteria,4NEQ0@976|Bacteroidetes,2FMKD@200643|Bacteroidia 976|Bacteroidetes EF Carbamoyl-phosphate synthase (glutamine-hydrolyzing) carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_739860_1 886379.AEWI01000029_gene201 8.88e-12 68.6 COG4775@1|root,COG4775@2|Bacteria,4NF38@976|Bacteroidetes,2FRYR@200643|Bacteroidia,3XJC0@558415|Marinilabiliaceae 976|Bacteroidetes M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_708438_1 395495.Lcho_1729 5.52e-48 164.0 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2VHCA@28216|Betaproteobacteria,1KIVF@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_871168_1 1410626.JHXB01000006_gene1812 3.68e-73 237.0 COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,27J7N@186928|unclassified Lachnospiraceae 186801|Clostridia S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_381618_1 1408473.JHXO01000004_gene31 6.28e-11 62.0 COG0775@1|root,COG0775@2|Bacteria,4NQVQ@976|Bacteroidetes 976|Bacteroidetes F Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnB - 3.2.2.26 ko:K11783 ko00130,ko01110,map00130,map01110 - R08587 RC00063,RC00318 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_381618_2 1168034.FH5T_01430 2.11e-65 207.0 COG0451@1|root,COG0451@2|Bacteria,4NIZG@976|Bacteroidetes 976|Bacteroidetes GM Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_250619_1 1168034.FH5T_03830 3e-46 157.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - OMP_b-brl k59_446144_2 1122201.AUAZ01000019_gene1741 2.95e-05 50.4 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria,4676I@72275|Alteromonadaceae 1236|Gammaproteobacteria KLT Sel1-like repeats. ybeQ - - ko:K07126 - - - - ko00000 - - - Sel1 k59_871170_1 768671.ThimaDRAFT_3391 1.58e-46 156.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,1WX61@135613|Chromatiales 135613|Chromatiales S PKHD-type hydroxylase - - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_969913_1 1476973.JMMB01000007_gene2120 1.18e-56 200.0 COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,25QNC@186804|Peptostreptococcaceae 186801|Clostridia L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity - - 3.1.11.5 ko:K01144,ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,UvrD_C_2,Viral_helicase1 k59_545559_1 1123393.KB891326_gene42 9.59e-121 386.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,1KSRI@119069|Hydrogenophilales 119069|Hydrogenophilales G Glycosyl hydrolase 36 superfamily, catalytic domain - - - - - - - - - - - - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_52697_1 573370.DMR_36450 1.26e-33 135.0 COG0457@1|root,COG0457@2|Bacteria,1QY6N@1224|Proteobacteria,42XBU@68525|delta/epsilon subdivisions,2WT6X@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_643560_1 1027292.HMPREF9372_1940 2.76e-18 91.3 COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,4HA11@91061|Bacilli,26E23@186818|Planococcaceae 91061|Bacilli P Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain cdr - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_413675_1 883080.HMPREF9697_02831 2.61e-102 316.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,3JSWQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_350149_1 1147.D082_04290 2.84e-50 184.0 COG0823@1|root,COG2373@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4932@1|root,COG0823@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,1G689@1117|Cyanobacteria 1117|Cyanobacteria Q Domain of unknown function (DUF4114) - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Calx-beta,DUF4114,DUF4347,HemolysinCabind,VCBS k59_186502_1 387093.SUN_0222 1.47e-81 248.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42MZF@68525|delta/epsilon subdivisions,2YMQX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_1034431_1 1165841.SULAR_04147 3.16e-88 263.0 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,42QSH@68525|delta/epsilon subdivisions,2YNVB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_1034431_2 749222.Nitsa_1122 4.83e-70 214.0 COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,42SAN@68525|delta/epsilon subdivisions,2YPGI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_1034431_3 749222.Nitsa_1121 1.79e-15 74.3 COG1994@1|root,COG1994@2|Bacteria,1N531@1224|Proteobacteria,43AZN@68525|delta/epsilon subdivisions,2YP0U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_676925_1 240016.ABIZ01000001_gene3227 6.95e-95 286.0 COG1077@1|root,COG1077@2|Bacteria,46SAA@74201|Verrucomicrobia,2ITYI@203494|Verrucomicrobiae 203494|Verrucomicrobiae D Actin - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_545569_1 563040.Saut_0949 2.56e-84 251.0 COG0537@1|root,COG0537@2|Bacteria,1RHYQ@1224|Proteobacteria,42SEG@68525|delta/epsilon subdivisions,2YNWN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FG HIT family - - - - - - - - - - - - HIT k59_545569_3 123214.PERMA_1600 3.16e-22 89.4 COG0011@1|root,COG0011@2|Bacteria,2G43G@200783|Aquificae 200783|Aquificae S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP k59_578000_1 553973.CLOHYLEM_07707 3.94e-31 122.0 COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes 1239|Firmicutes G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 k59_1034434_1 1049564.TevJSym_af00710 3.4e-32 121.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1J6D1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_1034434_2 658088.HMPREF0987_02666 2.96e-08 57.4 COG1194@1|root,COG1489@1|root,COG1194@2|Bacteria,COG1489@2|Bacteria,1TPUT@1239|Firmicutes,25E4K@186801|Clostridia,27K05@186928|unclassified Lachnospiraceae 186801|Clostridia L NUDIX domain mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4,SfsA k59_802940_1 1049564.TevJSym_af00840 1.56e-33 129.0 COG3249@1|root,COG3249@2|Bacteria,1N0PD@1224|Proteobacteria,1S9C4@1236|Gammaproteobacteria,1J69V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria VV2512 - - ko:K09938 - - - - ko00000 - - - DUF2066 k59_87313_1 1254432.SCE1572_17565 7.03e-50 177.0 COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin k59_545575_1 1122135.KB893134_gene3729 9.66e-31 115.0 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome b561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB,YceI k59_186507_1 63737.Npun_F5035 3.18e-44 164.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3290@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3290@2|Bacteria,1G09B@1117|Cyanobacteria,1HRFM@1161|Nostocales 1117|Cyanobacteria T response regulator, receiver - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_839161_1 411465.PEPMIC_01625 2.74e-18 79.0 COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,22HB9@1570339|Peptoniphilaceae 186801|Clostridia J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_839161_2 309803.CTN_1002 1.07e-20 85.9 COG0186@1|root,COG0186@2|Bacteria,2GD97@200918|Thermotogae 200918|Thermotogae J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_1034439_1 1454202.PPBDW_90321___1 4.54e-92 279.0 2DBB6@1|root,2Z85M@2|Bacteria,1QMDX@1224|Proteobacteria,1RZPX@1236|Gammaproteobacteria,1XW23@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_969953_1 1121396.KB892951_gene2951 0.000133 46.6 2DG6F@1|root,2ZUQJ@2|Bacteria,1Q849@1224|Proteobacteria,433EQ@68525|delta/epsilon subdivisions,2WY72@28221|Deltaproteobacteria,2MP42@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_186509_1 1313304.CALK_0611 9.26e-85 264.0 COG0527@1|root,COG0527@2|Bacteria 2|Bacteria E aspartate kinase activity lysC GO:0000166,GO:0003674,GO:0003824,GO:0004072,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017076,GO:0019202,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU03790 AA_kinase,ACT,ACT_7 k59_718751_2 760154.Sulba_0090 4.36e-45 154.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2YMC6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0566 DAP_epimerase k59_947944_1 216142.LT40_13290 2.51e-17 87.8 2DBQ2@1|root,2ZABR@2|Bacteria,1R4SC@1224|Proteobacteria,1SF73@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_130637_1 1121396.KB893108_gene1856 3.37e-87 274.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2MI2W@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_1434 Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1012735_1 1121468.AUBR01000040_gene1730 2.02e-07 49.7 COG1908@1|root,COG1908@2|Bacteria,1V638@1239|Firmicutes,24J0E@186801|Clostridia,42IDY@68295|Thermoanaerobacterales 186801|Clostridia C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_1012735_2 1167006.UWK_01658 6.88e-21 90.9 2E6WH@1|root,331G1@2|Bacteria,1NCI3@1224|Proteobacteria,42V38@68525|delta/epsilon subdivisions,2WRZD@28221|Deltaproteobacteria,2MKW9@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_783965_1 382464.ABSI01000002_gene4373 2.04e-58 197.0 COG4656@1|root,COG4656@2|Bacteria,46W83@74201|Verrucomicrobia 74201|Verrucomicrobia C RnfC Barrel sandwich hybrid domain - - - - - - - - - - - - Complex1_51K,Fer4_17,RnfC_N,SLBB k59_848682_1 195250.CM001776_gene952 1.23e-86 267.0 COG4974@1|root,COG4974@2|Bacteria,1G4JW@1117|Cyanobacteria,1GZF3@1129|Synechococcus 1117|Cyanobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_62993_1 502025.Hoch_6187 6.65e-58 199.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 k59_783968_1 933262.AXAM01000001_gene340 1.81e-78 253.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHT0@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_97582_1 709032.Sulku_1358 6.5e-36 132.0 COG3076@1|root,COG3076@2|Bacteria,1N195@1224|Proteobacteria,430TX@68525|delta/epsilon subdivisions,2YS1B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Family of unknown function (DUF695) - - - - - - - - - - - - DUF695,RraB k59_97582_3 929558.SMGD1_0003 1.26e-73 242.0 2AJGC@1|root,31A2T@2|Bacteria,1Q4TA@1224|Proteobacteria,42ZUH@68525|delta/epsilon subdivisions,2YRV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_423598_1 1379270.AUXF01000006_gene147 9.94e-66 203.0 COG1762@1|root,COG1762@2|Bacteria,1ZTIY@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_813653_1 929558.SMGD1_0554 4.82e-88 263.0 COG3381@1|root,COG3381@2|Bacteria,1N4MX@1224|Proteobacteria,42RVB@68525|delta/epsilon subdivisions,2YP5X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S component of anaerobic - - - - - - - - - - - - Nitrate_red_del k59_813653_2 1172190.M947_10890 3.21e-62 206.0 COG1143@1|root,COG2768@1|root,COG1143@2|Bacteria,COG2768@2|Bacteria,1N7HT@1224|Proteobacteria,42RFF@68525|delta/epsilon subdivisions,2YP9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 k59_718806_1 1168034.FH5T_18935 1.02e-126 379.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE71@976|Bacteroidetes,2FQB7@200643|Bacteroidia 976|Bacteroidetes C dehydrogenase E1 component bfmBAB - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_718806_2 1168034.FH5T_18930 1.94e-33 125.0 COG0508@1|root,COG0508@2|Bacteria,4NED0@976|Bacteroidetes,2FNQF@200643|Bacteroidia 976|Bacteroidetes C COG COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes bfmBB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_653655_1 563040.Saut_0697 6.8e-88 273.0 COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2YMT7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_27049_1 331678.Cphamn1_2249 5.91e-72 228.0 COG3177@1|root,COG3177@2|Bacteria,1FE4V@1090|Chlorobi 1090|Chlorobi S PFAM filamentation induced by cAMP protein Fic - - - - - - - - - - - - Fic,Fic_N k59_881303_2 1118057.CAGX01000047_gene819 1.28e-05 48.9 COG0071@1|root,COG0071@2|Bacteria,1VG0E@1239|Firmicutes,24SVC@186801|Clostridia,22HT8@1570339|Peptoniphilaceae 186801|Clostridia O Belongs to the small heat shock protein (HSP20) family - - - - - - - - - - - - HSP20 k59_423617_1 929558.SMGD1_0785 4.45e-135 404.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2YMHD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_488461_2 435591.BDI_3148 5.97e-88 270.0 COG1108@1|root,COG1108@2|Bacteria,4NH3D@976|Bacteroidetes,2FNK0@200643|Bacteroidia,22W1V@171551|Porphyromonadaceae 976|Bacteroidetes P ABC 3 transport family protein znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_488461_3 709991.Odosp_2169 4.5e-81 250.0 COG1121@1|root,COG1121@2|Bacteria,4NHZ9@976|Bacteroidetes,2FM2P@200643|Bacteroidia,22VV3@171551|Porphyromonadaceae 976|Bacteroidetes P ABC transporter, ATP-binding protein znuC - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_488461_4 572544.Ilyop_0639 1.5e-148 447.0 COG0616@1|root,COG0616@2|Bacteria,378X9@32066|Fusobacteria 32066|Fusobacteria OU signal peptide peptidase SppA, 36K type sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_488461_6 702450.CUW_0583 7.37e-07 53.1 COG1585@1|root,COG1585@2|Bacteria,1VAS9@1239|Firmicutes,3VQSA@526524|Erysipelotrichia 526524|Erysipelotrichia OU COG COG1585 Membrane protein implicated in regulation of membrane protease activity - - - - - - - - - - - - NfeD k59_292258_1 349124.Hhal_1227 3.79e-24 101.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales 135613|Chromatiales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_813667_1 563040.Saut_1008 3.01e-101 324.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2YMA1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_783991_2 469618.FVAG_02227 1.08e-18 82.8 COG1475@1|root,COG1475@2|Bacteria,37AG9@32066|Fusobacteria 32066|Fusobacteria K ParB-like nuclease domain - - - - - - - - - - - - ParBc k59_653673_1 746697.Aeqsu_2110 0.000623 47.8 COG0739@1|root,COG0739@2|Bacteria 2|Bacteria M heme binding - - - ko:K08642 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002 - - - GBS_Bsp-like,OapA,Peptidase_M23,SH3_3,VCBS k59_947978_1 1408473.JHXO01000001_gene2266 1.24e-64 202.0 COG1670@1|root,COG1670@2|Bacteria,4NQ4Z@976|Bacteroidetes,2FSTX@200643|Bacteroidia 976|Bacteroidetes J Acetyltransferase, gnat family - - - ko:K03817 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_3 k59_63004_2 439235.Dalk_0217 1.16e-21 95.9 COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2WJPG@28221|Deltaproteobacteria,2MI4A@213118|Desulfobacterales 28221|Deltaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_63005_1 1168034.FH5T_05235 2.85e-72 234.0 COG5010@1|root,COG5010@2|Bacteria,4PMJW@976|Bacteroidetes,2G0E2@200643|Bacteroidia 976|Bacteroidetes U COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_8 k59_947983_1 443144.GM21_0370 7.52e-07 48.9 COG2963@1|root,COG2963@2|Bacteria,1R0AN@1224|Proteobacteria 1224|Proteobacteria L transposase activity - - - - - - - - - - - - HTH_Tnp_1 k59_947983_2 76114.ebA5932 7.79e-60 195.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,2VKPT@28216|Betaproteobacteria,2KYCX@206389|Rhodocyclales 206389|Rhodocyclales L Homeodomain-like domain - - - - - - - - - - - - HTH_32,rve k59_718832_1 880070.Cycma_3448 2.9e-64 212.0 COG5421@1|root,COG5421@2|Bacteria,4NK89@976|Bacteroidetes,47U0X@768503|Cytophagia 976|Bacteroidetes L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_27065_1 563040.Saut_0866 3.57e-26 104.0 COG3267@1|root,COG3267@2|Bacteria,1QUIM@1224|Proteobacteria,42NAC@68525|delta/epsilon subdivisions,2YNHY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U ATPase (AAA - - 4.3.3.7 ko:K01714,ko:K12283 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000,ko02044 - - - AAA_22 k59_27065_2 1249480.B649_08735 8.07e-100 310.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,43BJ2@68525|delta/epsilon subdivisions,2YN49@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II and III secretion system protein ctsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - STN,Secretin,Secretin_N_2 k59_261001_1 335543.Sfum_2956 6.11e-120 363.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,2MQ9F@213462|Syntrophobacterales 28221|Deltaproteobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_980057_1 1123326.JFBL01000015_gene2424 1.81e-30 110.0 COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,42SAN@68525|delta/epsilon subdivisions,2YPGI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_30452_2 1168034.FH5T_07260 9.41e-67 205.0 COG0864@1|root,COG0864@2|Bacteria,4NTBC@976|Bacteroidetes,2FUBM@200643|Bacteroidia 976|Bacteroidetes K transcriptional regulator - - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_30454_2 1172190.M947_04120 1.2e-112 329.0 COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,42N9F@68525|delta/epsilon subdivisions,2YNBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_816948_1 391615.ABSJ01000026_gene84 4.21e-116 346.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1J4Z7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Isocitrate icd GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh k59_817044_1 396588.Tgr7_3302 3.63e-94 293.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales 135613|Chromatiales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_817052_1 1168034.FH5T_12730 1.31e-33 122.0 COG0007@1|root,COG0007@2|Bacteria,4NFVR@976|Bacteroidetes,2G3DU@200643|Bacteroidia 976|Bacteroidetes H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.107,4.2.1.75 ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,NAD_binding_7,Porphobil_deam,TP_methylase k59_817052_2 1168034.FH5T_12725 7.16e-38 134.0 COG0451@1|root,COG0451@2|Bacteria,4NMWC@976|Bacteroidetes 976|Bacteroidetes GM epimerase yeeZ - - - - - - - - - - - Epimerase,NAD_binding_10,NAD_binding_2 k59_30617_1 909663.KI867150_gene332 3.37e-38 140.0 COG0845@1|root,COG0845@2|Bacteria,1RC4B@1224|Proteobacteria,42T2B@68525|delta/epsilon subdivisions,2WPEV@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_817073_1 981085.XP_010089870.1 1.85e-113 328.0 COG1290@1|root,KOG4663@2759|Eukaryota,37QS7@33090|Viridiplantae,3GHBB@35493|Streptophyta,4JPQB@91835|fabids 35493|Streptophyta C cytochrome b6 petB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0016020,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 - ko:K02635,ko:K02704 ko00195,ko01100,map00195,map01100 M00161,M00162 - - ko00000,ko00001,ko00002,ko00194 - - - Cytochrom_B_C,Cytochrome_B k59_30724_1 1122226.AUHX01000005_gene2472 3.46e-21 94.4 COG0739@1|root,COG0739@2|Bacteria,4NED7@976|Bacteroidetes,1HXKD@117743|Flavobacteriia 976|Bacteroidetes M peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_30768_1 530564.Psta_3128 8.66e-14 73.2 COG0149@1|root,COG0149@2|Bacteria,2IXV9@203682|Planctomycetes 203682|Planctomycetes G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_30768_5 926560.KE387023_gene3245 3.36e-64 216.0 COG1459@1|root,COG1459@2|Bacteria,1WIU3@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus NU PFAM Bacterial type II secretion system protein F domain pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_30784_1 926556.Echvi_0496 2.63e-122 355.0 COG3507@1|root,COG3507@2|Bacteria,4NDUM@976|Bacteroidetes,47KAS@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 k59_31068_1 765911.Thivi_1704 4.74e-104 332.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_31184_1 1165841.SULAR_07770 9.93e-282 785.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,42P71@68525|delta/epsilon subdivisions,2YNAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Phospholipid glycerol acyltransferase - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_31184_2 1165841.SULAR_07790 2.45e-28 107.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42PA1@68525|delta/epsilon subdivisions,2YNMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_31381_1 1384056.N787_13430 1.66e-53 182.0 COG0451@1|root,COG0451@2|Bacteria,1RBSM@1224|Proteobacteria,1SBZE@1236|Gammaproteobacteria,1X8QV@135614|Xanthomonadales 135614|Xanthomonadales GM NAD dependent epimerase/dehydratase family - - 1.3.1.45 ko:K05281 ko00943,ko01110,map00943,map01110 - R06562,R06563,R07747,R07751 RC00805 ko00000,ko00001,ko01000 - - - Epimerase k59_31406_1 563040.Saut_1576 2.07e-20 93.2 COG2165@1|root,COG2165@2|Bacteria,1NC62@1224|Proteobacteria,42SHI@68525|delta/epsilon subdivisions,2YPH0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU general secretion pathway protein - - - - - - - - - - - - N_methyl k59_31536_1 1121403.AUCV01000016_gene4398 4.59e-82 265.0 COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,42SXG@68525|delta/epsilon subdivisions,2WP6Y@28221|Deltaproteobacteria,2MNMK@213118|Desulfobacterales 28221|Deltaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C,PAP2,SNARE_assoc k59_31552_1 1095767.CAHD01000011_gene826 3.91e-78 242.0 COG0524@1|root,COG0524@2|Bacteria,2GYHF@201174|Actinobacteria,4F15D@85016|Cellulomonadaceae 201174|Actinobacteria G PFAM PfkB domain protein cscK - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_31552_2 471853.Bcav_1094 2.55e-06 48.1 COG0288@1|root,COG0288@2|Bacteria,2GT5H@201174|Actinobacteria 201174|Actinobacteria P reversible hydration of carbon dioxide cynT GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_31564_1 1167006.UWK_01153 1.91e-94 291.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria,2MI2D@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_31726_1 1236959.BAMT01000002_gene2168 2.43e-38 136.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2WHA3@28216|Betaproteobacteria,2KNEB@206350|Nitrosomonadales 206350|Nitrosomonadales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_31726_2 768671.ThimaDRAFT_1693 1.11e-104 314.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,1WXRH@135613|Chromatiales 135613|Chromatiales S PFAM Bile acid sodium symporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_31755_1 335543.Sfum_0103 2.24e-36 132.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,42PX9@68525|delta/epsilon subdivisions,2WIPW@28221|Deltaproteobacteria,2MQSZ@213462|Syntrophobacterales 28221|Deltaproteobacteria S SMART Elongator protein 3 MiaB NifB yhcC-1 - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_31762_2 1283300.ATXB01000001_gene1421 1.47e-75 243.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,1XDP1@135618|Methylococcales 135618|Methylococcales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA - 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_31788_1 247639.MGP2080_08144 2.65e-108 330.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria 1236|Gammaproteobacteria EQ COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_31851_1 572544.Ilyop_0454 7.33e-180 513.0 COG1027@1|root,COG1027@2|Bacteria,3799E@32066|Fusobacteria 32066|Fusobacteria E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 k59_31851_3 574966.KB898646_gene2864 1.75e-41 144.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1XKE3@135619|Oceanospirillales 135619|Oceanospirillales H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_31851_4 1278306.KB906926_gene1660 0.000129 43.5 COG1309@1|root,COG1309@2|Bacteria,37ACT@32066|Fusobacteria 32066|Fusobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_31851_5 582515.KR51_00029930 3.02e-27 109.0 COG0797@1|root,COG0797@2|Bacteria,1G0XF@1117|Cyanobacteria 1117|Cyanobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1 k59_31851_6 572544.Ilyop_0455 7.21e-233 648.0 COG0486@1|root,COG0486@2|Bacteria,378H3@32066|Fusobacteria 32066|Fusobacteria S 50S ribosome-binding GTPase hydF - - - - - - - - - - - MMR_HSR1 k59_31851_7 1128398.Curi_c06800 6.16e-149 427.0 COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia,268W2@186813|unclassified Clostridiales 186801|Clostridia S Nitronate monooxygenase - - - - - - - - - - - - NMO k59_31851_8 469617.FUAG_01128 2.84e-27 107.0 COG1399@1|root,COG1399@2|Bacteria,37A8U@32066|Fusobacteria 32066|Fusobacteria S Uncharacterized ACR, COG1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_31851_9 1319815.HMPREF0202_02158 8.26e-28 101.0 COG0333@1|root,COG0333@2|Bacteria,37AZ8@32066|Fusobacteria 32066|Fusobacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0003674,GO:0003735,GO:0005198 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_31851_10 1319815.HMPREF0202_02157 2.68e-106 318.0 COG0416@1|root,COG0416@2|Bacteria,3791E@32066|Fusobacteria 32066|Fusobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_31955_2 396588.Tgr7_0692 1.5e-67 218.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_32052_1 469616.FMAG_01500 3.58e-09 56.6 COG0191@1|root,COG0191@2|Bacteria,378NH@32066|Fusobacteria 32066|Fusobacteria G Fructose-bisphosphate aldolase class-II gPI - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_32052_2 1278306.KB906913_gene926 9.98e-25 99.4 2DU41@1|root,32UWJ@2|Bacteria,37AUF@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - CbiQ k59_32197_1 1172190.M947_06995 1.16e-44 160.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2YMZ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M N-acetylmuramoyl-L-alanine amidase amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_952396_1 452637.Oter_1466 1.64e-266 749.0 COG0243@1|root,COG0243@2|Bacteria,46U1H@74201|Verrucomicrobia 74201|Verrucomicrobia C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_331715_1 156889.Mmc1_2259 3.25e-49 169.0 COG1077@1|root,COG1077@2|Bacteria,1PNT2@1224|Proteobacteria,2UQZ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria D MreB/Mbl protein - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_298338_2 572544.Ilyop_0815 2.69e-30 118.0 COG1232@1|root,COG1232@2|Bacteria 2|Bacteria H protoporphyrinogen oxidase activity - - 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 - R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 - - - Amino_oxidase,NAD_binding_8 k59_298338_3 572544.Ilyop_0815 2.04e-116 346.0 COG1232@1|root,COG1232@2|Bacteria 2|Bacteria H protoporphyrinogen oxidase activity - - 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 - R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 - - - Amino_oxidase,NAD_binding_8 k59_69740_1 509635.N824_24620 1.01e-35 132.0 COG2354@1|root,COG2354@2|Bacteria,4NG5M@976|Bacteroidetes,1IPWV@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF808) yedI - - ko:K09781 - - - - ko00000 - - - DUF808 k59_298340_1 688245.CtCNB1_4431 3.37e-18 78.2 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2VR2K@28216|Betaproteobacteria,4AE45@80864|Comamonadaceae 28216|Betaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_298340_2 243233.MCA2351 1.01e-16 71.6 COG0257@1|root,COG0257@2|Bacteria,1PUHG@1224|Proteobacteria,1THVP@1236|Gammaproteobacteria,1XFUJ@135618|Methylococcales 135618|Methylococcales J Belongs to the bacterial ribosomal protein bL36 family rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 k59_495053_1 1384056.N787_00920 1.25e-83 274.0 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1X3P0@135614|Xanthomonadales 135614|Xanthomonadales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_527894_1 572544.Ilyop_R0032 4.3e-12 65.5 COG1292@1|root,COG1292@2|Bacteria,37AIW@32066|Fusobacteria 32066|Fusobacteria M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K02168 - - - - ko00000,ko02000 2.A.15.1.3,2.A.15.1.4 - - BCCT k59_428989_1 398580.Dshi_3330 2.41e-13 70.5 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_428989_2 237368.SCABRO_01291 3.51e-56 192.0 COG2987@1|root,COG2987@2|Bacteria,2IYV3@203682|Planctomycetes 203682|Planctomycetes E Urocanase C-terminal domain - - - - - - - - - - - - Urocanase,Urocanase_C,Urocanase_N k59_396808_2 214092.YPO0047 9.62e-80 239.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,41EZ8@629|Yersinia 1236|Gammaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_592443_2 1121875.KB907546_gene2203 6.91e-08 54.3 COG2367@1|root,COG2367@2|Bacteria,4NE3C@976|Bacteroidetes,1HZYJ@117743|Flavobacteriia 976|Bacteroidetes V beta-lactamase per1 - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_658737_1 690850.Desaf_0899 6.61e-26 100.0 COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,42TPF@68525|delta/epsilon subdivisions,2WR03@28221|Deltaproteobacteria,2MDNU@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_364091_1 7070.TC014826-PA 1.41e-08 64.3 COG0666@1|root,KOG4177@2759|Eukaryota 2759|Eukaryota I spectrin binding - - - - - - - - - - - - Ank,Ank_2 k59_364091_2 589924.Ferp_2200 1.87e-26 104.0 COG2062@1|root,arCOG01992@2157|Archaea,2Y26Y@28890|Euryarchaeota,24776@183980|Archaeoglobi 183980|Archaeoglobi T Histidine phosphatase superfamily (branch 1) - - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_364091_3 945713.IALB_0068 1.87e-16 84.0 COG0514@1|root,COG1040@1|root,COG0514@2|Bacteria,COG1040@2|Bacteria 2|Bacteria K competence protein comF - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - Pribosyltran k59_396810_1 335543.Sfum_1359 1.82e-18 84.7 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJN6@28221|Deltaproteobacteria,2MQ5G@213462|Syntrophobacterales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_298349_2 1168034.FH5T_06465 1.47e-137 392.0 COG3340@1|root,COG3340@2|Bacteria,4NEXW@976|Bacteroidetes,2FQTC@200643|Bacteroidia 976|Bacteroidetes E Belongs to the peptidase S51 family pepE - 3.4.13.21 ko:K05995 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S51 k59_723525_1 325452.fgenesh_scip_prom.46568.2276 1.1e-24 106.0 COG0339@1|root,COG0363@1|root,COG0464@1|root,KOG0741@2759|Eukaryota,KOG2089@2759|Eukaryota,KOG3147@2759|Eukaryota,3Q96E@4776|Peronosporales 4776|Peronosporales O AAA domain (Cdc48 subfamily) - - 3.6.4.6 ko:K06027 ko04138,ko04721,ko04727,ko04962,map04138,map04721,map04727,map04962 - - - ko00000,ko00001,ko01000,ko04131 1.F.1.1 - - AAA k59_102938_1 526218.Sterm_2584 4.18e-17 81.6 2EUJY@1|root,33N1W@2|Bacteria,37B89@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_102938_2 572544.Ilyop_0767 2e-58 186.0 COG4122@1|root,COG4122@2|Bacteria,379F0@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score - - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 k59_265588_1 348824.LPU83_1088 6.58e-12 68.9 COG1011@1|root,COG1011@2|Bacteria,1RHAB@1224|Proteobacteria,2U7PV@28211|Alphaproteobacteria,4B9YU@82115|Rhizobiaceae 28211|Alphaproteobacteria S Hydrolase - - 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_265588_2 156889.Mmc1_0128 2.86e-32 115.0 COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2U9M1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria - - - ko:K09922 - - - - ko00000 - - - DMT_6 k59_69760_1 1123256.KB907940_gene199 7.45e-89 270.0 COG0596@1|root,COG0596@2|Bacteria,1N252@1224|Proteobacteria,1T5N0@1236|Gammaproteobacteria,1XDFW@135614|Xanthomonadales 135614|Xanthomonadales S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_821787_1 879212.DespoDRAFT_00885 6.4e-23 103.0 COG0840@1|root,COG0840@2|Bacteria,1RFH2@1224|Proteobacteria,42YXY@68525|delta/epsilon subdivisions,2WUDW@28221|Deltaproteobacteria,2MMQN@213118|Desulfobacterales 28221|Deltaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,Hemerythrin,MCPsignal k59_690920_1 686578.AFFX01000004_gene3682 5.47e-23 102.0 28IAG@1|root,2Z8D2@2|Bacteria,1P5EH@1224|Proteobacteria,1RYCA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF4129 k59_723536_1 709032.Sulku_0999 8.46e-82 250.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,42R50@68525|delta/epsilon subdivisions,2YNX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - - - - - - - - - - MoCF_biosynth k59_265598_1 694427.Palpr_0868 5.6e-63 207.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,4NDVS@976|Bacteroidetes,2FWNG@200643|Bacteroidia 976|Bacteroidetes CO L-lysine 6-monooxygenase (NADPH-requiring) - - - - - - - - - - - - Fer4_10,Pyr_redox_3 k59_200464_1 709032.Sulku_2135 1.66e-10 60.5 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2YMID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_364120_1 1168034.FH5T_10930 4.65e-36 131.0 COG0045@1|root,COG0045@2|Bacteria,4NFHA@976|Bacteroidetes,2FNFG@200643|Bacteroidia 976|Bacteroidetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_364120_2 1168034.FH5T_10935 5.64e-90 270.0 COG0074@1|root,COG0074@2|Bacteria,4NE6B@976|Bacteroidetes,2FM2M@200643|Bacteroidia 976|Bacteroidetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA,Succ_CoA_lig k59_886530_1 506534.Rhein_1402 1.02e-25 96.7 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1WZ2Z@135613|Chromatiales 135613|Chromatiales K PFAM Cold-shock protein, DNA-binding - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_985016_1 572544.Ilyop_0607 1.41e-142 458.0 COG2911@1|root,COG2911@2|Bacteria,3792H@32066|Fusobacteria 32066|Fusobacteria S Psort location OuterMembrane, score - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_723542_1 66874.JOFS01000092_gene8388 2.89e-30 120.0 COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_854456_1 203122.Sde_2846 1.2e-24 107.0 COG0725@1|root,COG4149@1|root,COG0725@2|Bacteria,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,465C4@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG4149 ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_3080_1 471853.Bcav_3816 2.26e-93 287.0 COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria 201174|Actinobacteria CP Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit mrpD - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_233464_1 1116375.VEJY3_18826 1.71e-76 236.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XVRQ@135623|Vibrionales 135623|Vibrionales Q COG4663 TRAP-type mannitol chloroaromatic compound transport system, periplasmic component - - - - - - - - - - - - DctP k59_625583_1 333138.LQ50_14500 6.93e-161 457.0 COG1082@1|root,COG1082@2|Bacteria,1VCQ8@1239|Firmicutes,4IF2R@91061|Bacilli,1ZE41@1386|Bacillus 91061|Bacilli G Xylose isomerase-like TIM barrel - - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_985022_1 1168034.FH5T_05115 4.7e-11 62.0 COG0466@1|root,COG0466@2|Bacteria,4NE1G@976|Bacteroidetes,2FNKR@200643|Bacteroidia 976|Bacteroidetes O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_985022_2 1168034.FH5T_05100 1.34e-60 187.0 COG2151@1|root,COG2151@2|Bacteria,4NSA9@976|Bacteroidetes,2FT2N@200643|Bacteroidia 976|Bacteroidetes S FeS assembly SUF system protein yitW - - - - - - - - - - - FeS_assembly_P k59_985022_3 1168034.FH5T_05095 4.46e-82 244.0 COG2166@1|root,COG2166@2|Bacteria,4NM9N@976|Bacteroidetes,2FSRV@200643|Bacteroidia 976|Bacteroidetes S Fe-S metabolism associated domain protein sufE - - ko:K02426 - - - - ko00000 - - - SufE k59_135749_1 1217718.ALOU01000007_gene1227 1.45e-70 241.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria 28216|Betaproteobacteria M surface antigen variable number repeat protein - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_1017839_1 29176.XP_003881893.1 7.25e-10 58.9 COG2110@1|root,KOG2633@2759|Eukaryota,3YC53@5794|Apicomplexa,3YMBU@5796|Coccidia,3YT8N@5809|Sarcocystidae 5794|Apicomplexa BK Appr-1'-p processing enzyme - - - - - - - - - - - - Macro k59_1017839_2 1168034.FH5T_13490 2.07e-59 197.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_168552_1 399739.Pmen_3841 6.51e-16 77.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1YD08@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispA GO:0003674,GO:0003824,GO:0004161,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - iPC815.YPO3176,iSFV_1184.SFV_0386 polyprenyl_synt k59_168552_2 1249627.D779_3800 3.12e-69 218.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales 135613|Chromatiales S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_788974_1 526218.Sterm_1028 6.08e-19 85.1 COG2099@1|root,COG2099@2|Bacteria,3792A@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score 8.96 cobK - 1.3.1.106,1.3.1.54 ko:K05895 ko00860,ko01100,map00860,map01100 - R05150,R05812 RC01280 ko00000,ko00001,ko01000 - - - CbiJ k59_298387_1 96561.Dole_3004 7.19e-77 234.0 COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,42QVP@68525|delta/epsilon subdivisions,2WMT7@28221|Deltaproteobacteria,2MJKZ@213118|Desulfobacterales 28221|Deltaproteobacteria C Prokaryotic cytochrome b561 cbcB - - - - - - - - - - - Ni_hydr_CYTB k59_788976_1 314285.KT71_01620 2.56e-39 147.0 COG4805@1|root,COG4805@2|Bacteria,1R4HM@1224|Proteobacteria,1SKZF@1236|Gammaproteobacteria,1J9TG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - - k59_233475_1 572544.Ilyop_1803 7.35e-93 271.0 COG0197@1|root,COG0197@2|Bacteria,37A0T@32066|Fusobacteria 32066|Fusobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_233475_2 1278306.KB906913_gene960 2.76e-28 102.0 COG0255@1|root,COG0255@2|Bacteria,37B2D@32066|Fusobacteria 32066|Fusobacteria J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_560662_1 469617.FUAG_01614 3.47e-105 308.0 COG0800@1|root,COG0800@2|Bacteria,378RP@32066|Fusobacteria 32066|Fusobacteria G PFAM KDPG and KHG aldolase eda - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_854476_1 504487.JCM19302_2860 1.6e-58 197.0 COG3004@1|root,COG3004@2|Bacteria,4NFC4@976|Bacteroidetes,1HXXZ@117743|Flavobacteriia 976|Bacteroidetes P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_495634_2 398720.MED217_06691 2.68e-44 147.0 COG4334@1|root,COG4334@2|Bacteria,4NU8F@976|Bacteroidetes,1I8NU@117743|Flavobacteriia 976|Bacteroidetes S Uncharacterized protein conserved in bacteria (DUF2255) - - - - - - - - - - - - DUF2255 k59_593118_1 1168034.FH5T_03820 7.41e-132 379.0 COG0741@1|root,COG0741@2|Bacteria,4NH4W@976|Bacteroidetes,2FM9R@200643|Bacteroidia 976|Bacteroidetes M Transglycosylase SLT domain mltD_2 - - - - - - - - - - - SLT k59_103603_1 1260251.SPISAL_04345 5.42e-09 56.2 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1WWV0@135613|Chromatiales 135613|Chromatiales E aminotransferase class I and II - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_103603_2 1562701.BBOF01000044_gene1230 6.56e-22 91.3 COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2VUF2@28216|Betaproteobacteria,1K7NX@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 k59_103603_8 1532557.JL37_06780 1.65e-10 62.4 2AGS9@1|root,31706@2|Bacteria,1PY8A@1224|Proteobacteria,2WDGQ@28216|Betaproteobacteria,3T8ES@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_103603_9 1049564.TevJSym_au00360 0.0 908.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1J5M4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region gsiA - - ko:K02031,ko:K02032,ko:K13896 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_103603_10 1049564.TevJSym_au00350 2.38e-230 647.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1J5IT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Binding-protein-dependent transport system inner membrane component oppC - - ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_103603_11 572477.Alvin_1058 4.64e-76 236.0 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,1WWCR@135613|Chromatiales 135613|Chromatiales K response regulator receiver - - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_103603_12 935567.JAES01000020_gene576 6.38e-80 257.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1X4F0@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_103603_13 1049564.TevJSym_ax00440 1.1e-47 155.0 COG1974@1|root,COG1974@2|Bacteria,1QUQ8@1224|Proteobacteria,1T20V@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_103603_14 1049564.TevJSym_ac00480 1.04e-220 621.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4I6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_103603_15 1049564.TevJSym_ac01690 2.63e-124 360.0 COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1JA86@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 k59_103603_16 1049564.TevJSym_ac01700 8.98e-126 384.0 COG5607@1|root,COG5607@2|Bacteria,1R5I1@1224|Proteobacteria,1S0QK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T pfam chad - - - - - - - - - - - - CHAD,His_Phos_1 k59_103603_17 1123355.JHYO01000012_gene708 2.71e-192 586.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,36XKH@31993|Methylocystaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg k59_103603_18 1049564.TevJSym_aw00020 0.0 1150.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1J4SD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0308 Aminopeptidase N pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042 DUF3458,DUF3458_C,Peptidase_M1 k59_103603_19 876044.IMCC3088_1706 2e-27 102.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1J6Z4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_103603_20 572477.Alvin_1022 2.14e-39 136.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1WYI6@135613|Chromatiales 135613|Chromatiales J Belongs to the HSP15 family - - - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_103603_21 1049564.TevJSym_am00690 1.09e-36 128.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1J6I8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein conserved in bacteria - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - DUF971 k59_103603_22 1163617.SCD_n02705 1.97e-23 94.0 COG0316@1|root,COG0316@2|Bacteria,1N8ZN@1224|Proteobacteria,2W5FR@28216|Betaproteobacteria 28216|Betaproteobacteria S Iron-sulphur cluster biosynthesis - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_103603_23 1163617.SCD_n02706 2.1e-200 571.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_103603_24 1049564.TevJSym_aw00090 2.4e-202 568.0 COG5557@1|root,COG5557@2|Bacteria 2|Bacteria C Polysulphide reductase, NrfD dsrP - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_103603_25 1249627.D779_2153 1.62e-116 341.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_7 k59_103603_26 1049564.TevJSym_aw00110 8.15e-41 139.0 2E6CU@1|root,3310G@2|Bacteria,1NBK1@1224|Proteobacteria,1S5EP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - dsrJ - - - - - - - - - - - - k59_829867_3 926692.AZYG01000036_gene2463 0.000126 43.5 COG1775@1|root,COG1775@2|Bacteria,1TSHM@1239|Firmicutes,249WE@186801|Clostridia 186801|Clostridia E PFAM 2-hydroxyglutaryl-CoA dehydratase D-component - - - - - - - - - - - - HGD-D k59_469998_1 1216932.CM240_0258 3.74e-37 131.0 COG0144@1|root,COG0144@2|Bacteria,1UHQD@1239|Firmicutes,25EJT@186801|Clostridia,36UVV@31979|Clostridiaceae 186801|Clostridia J Putative rRNA methylase - - - - - - - - - - - - rRNA_methylase k59_469998_2 1286171.EAL2_808p07660 7.6e-58 188.0 COG1878@1|root,COG1878@2|Bacteria,1TSXB@1239|Firmicutes,24B80@186801|Clostridia,25WY2@186806|Eubacteriaceae 186801|Clostridia S Putative cyclase - - - - - - - - - - - - Cyclase k59_469998_3 1499967.BAYZ01000028_gene1265 9.58e-60 201.0 COG1509@1|root,COG1509@2|Bacteria,2NNY6@2323|unclassified Bacteria 2|Bacteria E lysine 2,3-aminomutase activity kamA - 5.4.3.2 ko:K01843,ko:K19810 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000,ko03012 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_993905_1 933262.AXAM01000169_gene586 5.93e-53 175.0 2BIP4@1|root,32CWB@2|Bacteria,1R1ZD@1224|Proteobacteria,42SG9@68525|delta/epsilon subdivisions,2WPAA@28221|Deltaproteobacteria,2MK5A@213118|Desulfobacterales 28221|Deltaproteobacteria S RepB DNA-primase from phage plasmid - - - - - - - - - - - - RepB_primase k59_634430_1 1279019.ARQK01000031_gene1201 5.98e-39 149.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales 135613|Chromatiales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_145660_1 930169.B5T_04446 1.05e-72 233.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1XI7M@135619|Oceanospirillales 135619|Oceanospirillales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_373392_1 97139.C824_03345 1.71e-39 143.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,36E4H@31979|Clostridiaceae 186801|Clostridia J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_929645_1 933262.AXAM01000018_gene1016 2.71e-142 406.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42PYM@68525|delta/epsilon subdivisions,2WJ37@28221|Deltaproteobacteria,2MIP8@213118|Desulfobacterales 28221|Deltaproteobacteria C Electron transfer flavoprotein - - - ko:K03521 - - - - ko00000 - - - ETF k59_569645_1 768671.ThimaDRAFT_3833 5.6e-59 187.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1WW9M@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_569645_2 768671.ThimaDRAFT_3832 2.64e-62 197.0 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1WW5Q@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_896452_1 768706.Desor_2230 1.67e-46 158.0 COG1573@1|root,COG1573@2|Bacteria,1VGX6@1239|Firmicutes,25DJZ@186801|Clostridia 186801|Clostridia L Uracil DNA glycosylase superfamily - - - - - - - - - - - - UDG k59_896452_3 1121396.KB893095_gene4395 9.95e-78 241.0 28P1J@1|root,2ZBXX@2|Bacteria,1REYC@1224|Proteobacteria,42RM0@68525|delta/epsilon subdivisions,2WNN9@28221|Deltaproteobacteria,2MJS1@213118|Desulfobacterales 28221|Deltaproteobacteria S Pyrimidine dimer DNA glycosylase - - - - - - - - - - - - DUF1722,Pyr_excise k59_896452_4 1005995.GTPT_1221 1.13e-06 51.2 COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,1RQ95@1236|Gammaproteobacteria,4BTS6@82986|Tatumella 1236|Gammaproteobacteria S Sugar fermentation stimulation protein sfsA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044238,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K06206 - - - - ko00000 - - - SfsA k59_668402_1 381666.H16_A1172 2.44e-28 119.0 COG4255@1|root,COG4255@2|Bacteria,1Q1JF@1224|Proteobacteria,2WGEG@28216|Betaproteobacteria,1KG39@119060|Burkholderiaceae 28216|Betaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_862920_1 744872.Spica_2524 3.4e-125 381.0 COG3039@1|root,COG3039@2|Bacteria,2J9MX@203691|Spirochaetes 203691|Spirochaetes L Transposase - - - - - - - - - - - - DDE_Tnp_1_2,DUF772 k59_830763_1 742766.HMPREF9455_02483 0.000184 44.3 COG1595@1|root,COG1595@2|Bacteria,4NR0P@976|Bacteroidetes,2FN1H@200643|Bacteroidia,230AH@171551|Porphyromonadaceae 976|Bacteroidetes K RNA polymerase sigma-70 factor, Bacteroides expansion family 1 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_830763_2 1168034.FH5T_07755 2.28e-44 155.0 COG3712@1|root,COG3712@2|Bacteria,4NICU@976|Bacteroidetes,2FPP5@200643|Bacteroidia 976|Bacteroidetes PT Sigma factor regulatory protein, FecR PupR family - - - - - - - - - - - - DUF4974,FecR k59_731734_1 713586.KB900536_gene3064 1.65e-111 344.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_145672_1 1121957.ATVL01000008_gene4117 2.71e-82 255.0 COG1649@1|root,COG1649@2|Bacteria,4NGFW@976|Bacteroidetes,47T3X@768503|Cytophagia 976|Bacteroidetes S PFAM Uncharacterised BCR, COG1649 - - - - - - - - - - - - CBM9_1,GHL10 k59_111874_1 768671.ThimaDRAFT_0873 9.74e-16 77.4 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales 135613|Chromatiales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_111874_2 395964.KE386496_gene571 5.25e-10 62.0 COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,2U5WE@28211|Alphaproteobacteria,3NB7S@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_537618_1 1094715.CM001373_gene2411 2.29e-21 102.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1JC4N@118969|Legionellales 118969|Legionellales T sensory box histidine kinase response regulator - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_668418_1 1033802.SSPSH_001221 6.61e-89 266.0 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis rnt GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T k59_668418_2 1112274.KI911560_gene729 5.28e-13 68.2 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KKH8@206350|Nitrosomonadales 206350|Nitrosomonadales F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_307013_1 1385935.N836_13420 7.61e-12 70.5 COG0367@1|root,COG0367@2|Bacteria,1G3S7@1117|Cyanobacteria,1H8UK@1150|Oscillatoriales 1117|Cyanobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_794935_1 1168034.FH5T_15490 2.45e-181 511.0 COG1063@1|root,COG1063@2|Bacteria,4NHCK@976|Bacteroidetes,2FM1Q@200643|Bacteroidia 976|Bacteroidetes E Psort location Cytoplasmic, score 9.97 yjmD_1 - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_8724_1 1168034.FH5T_14755 1.21e-133 380.0 COG0177@1|root,COG0177@2|Bacteria,4NFF3@976|Bacteroidetes,2FM8U@200643|Bacteroidia 976|Bacteroidetes L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_8726_1 717772.THIAE_01395 2.13e-06 48.9 COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,462SR@72273|Thiotrichales 72273|Thiotrichales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_8726_2 1035191.HMPREF0185_01574 2.88e-07 52.0 COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,2TVBG@28211|Alphaproteobacteria 28211|Alphaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_668426_1 929558.SMGD1_1972 2.67e-144 425.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2YMF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_794945_1 313606.M23134_00483 8.36e-25 104.0 COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes,47MZ0@768503|Cytophagia 976|Bacteroidetes E Pyridoxal-dependent decarboxylase conserved domain - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC k59_794945_2 1408473.JHXO01000012_gene382 1.23e-31 121.0 COG2160@1|root,COG2160@2|Bacteria,4NHGG@976|Bacteroidetes,2FMIU@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the conversion of L-arabinose to L-ribulose araA - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Iso_C,Arabinose_Isome k59_178107_1 297246.lpp0997 5.88e-25 99.0 COG0589@1|root,COG0589@2|Bacteria,1RHE6@1224|Proteobacteria,1S9IV@1236|Gammaproteobacteria,1JE97@118969|Legionellales 118969|Legionellales T Universal stress protein uspA - - ko:K06149 - - - - ko00000 - - - Usp k59_178107_2 391615.ABSJ01000022_gene306 2.72e-48 164.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1J50Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S related to Ser Thr protein kinases - GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_307034_1 1307759.JOMJ01000004_gene2546 1.5e-24 110.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2WMD9@28221|Deltaproteobacteria,2M8AQ@213115|Desulfovibrionales 28221|Deltaproteobacteria Q Hemolysin-type calcium-binding region - - - - - - - - - - - - Cadherin_3,HCBP_related,He_PIG,HemolysinCabind,Peptidase_M91,VWA,VWA_2 k59_470853_1 1304275.C41B8_18104 5.17e-21 92.8 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_602768_1 1313301.AUGC01000019_gene737 1.42e-10 60.5 COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes 976|Bacteroidetes O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_79070_1 519989.ECTPHS_08783 6.46e-20 86.7 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1WX04@135613|Chromatiales 135613|Chromatiales D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_79070_2 1249627.D779_3083 1.4e-101 305.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales 135613|Chromatiales K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_145699_2 443143.GM18_2495 5.38e-70 223.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,43TBZ@69541|Desulfuromonadales 28221|Deltaproteobacteria U PFAM type II secretion system pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_44633_1 1168034.FH5T_12385 2.76e-101 319.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,4NEDE@976|Bacteroidetes,2FKZJ@200643|Bacteroidia 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_470855_2 1163409.UUA_10596 9.21e-51 166.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1X6H1@135614|Xanthomonadales 135614|Xanthomonadales S Glutamyl-tRNA amidotransferase - - - ko:K09117 - - - - ko00000 - - - YqeY k59_405631_1 640081.Dsui_0006 2.85e-12 63.9 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,2KX4B@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_405631_2 768671.ThimaDRAFT_0728 1.46e-31 115.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S2ZH@1236|Gammaproteobacteria,1WXZY@135613|Chromatiales 135613|Chromatiales S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_929690_1 338963.Pcar_0509 4.42e-70 218.0 COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,43U8B@69541|Desulfuromonadales 28221|Deltaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_242312_1 765912.Thimo_0535 1.77e-96 298.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RZWQ@1236|Gammaproteobacteria,1WW2K@135613|Chromatiales 135613|Chromatiales M PFAM Transglycosylase SLT domain - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_929692_1 396588.Tgr7_1508 3.75e-97 293.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1WWDK@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family - - 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - - Citrate_synt k59_961579_1 1453501.JELR01000002_gene164 4.91e-72 223.0 COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,466DA@72275|Alteromonadaceae 1236|Gammaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_111904_1 1168034.FH5T_07025 3.9e-67 228.0 COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,2FM0P@200643|Bacteroidia 976|Bacteroidetes G beta-galactosidase - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_668452_1 1479237.JMLY01000001_gene464 1.23e-23 99.8 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,465IU@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase IS116/IS110/IS902 family Z012_08285 - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_961584_1 1121413.JMKT01000005_gene999 7.44e-53 177.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42SM4@68525|delta/epsilon subdivisions,2WPVD@28221|Deltaproteobacteria,2MGHY@213115|Desulfovibrionales 28221|Deltaproteobacteria L Integrase core domain - - - - - - - - - - - - rve k59_994843_1 1168034.FH5T_10755 8.15e-173 513.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,4NE1X@976|Bacteroidetes,2FMPX@200643|Bacteroidia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_765256_1 1511.CLOST_0749 1.1e-90 277.0 COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,25SKH@186804|Peptostreptococcaceae 186801|Clostridia C Flavodoxin norV - - - - - - - - - - - Flavodoxin_1,Lactamase_B k59_437819_1 272559.BF9343_0943 7.1e-84 276.0 COG0653@1|root,COG0653@2|Bacteria,4NF7C@976|Bacteroidetes,2FMVF@200643|Bacteroidia,4AMYA@815|Bacteroidaceae 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_79091_1 572544.Ilyop_1194 1.1e-121 356.0 COG1135@1|root,COG1135@2|Bacteria,378UV@32066|Fusobacteria 32066|Fusobacteria P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system metN - - ko:K02071 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - ABC_tran,NIL k59_731789_1 83219.PM02_11095 2.43e-28 114.0 COG2755@1|root,COG2755@2|Bacteria,1RE1B@1224|Proteobacteria,2U779@28211|Alphaproteobacteria,3ZWY1@60136|Sulfitobacter 28211|Alphaproteobacteria E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_994847_2 1137799.GZ78_18715 8.26e-15 77.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1XI8J@135619|Oceanospirillales 135619|Oceanospirillales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_505474_2 251221.35213029 4.02e-19 84.7 COG2020@1|root,COG2020@2|Bacteria,1GB2G@1117|Cyanobacteria 1117|Cyanobacteria O Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - - - - - - - - - - PEMT k59_373454_1 929558.SMGD1_0288 5.32e-132 407.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YMMN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_79097_1 1165841.SULAR_10119 1.19e-28 109.0 COG3705@1|root,COG3705@2|Bacteria,1QV6Q@1224|Proteobacteria,43BNS@68525|delta/epsilon subdivisions,2YT9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - - - - - - - - - - tRNA-synt_His k59_79097_2 1165841.SULAR_10124 3.98e-67 213.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2YN1J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase - - - - - - - - - - - - Aminotran_5 k59_862990_1 421052.F945_02345 5.4e-15 80.5 COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,1RMKH@1236|Gammaproteobacteria,3NIWV@468|Moraxellaceae 1236|Gammaproteobacteria J Amidase nylA - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_273723_3 563040.Saut_2070 3.64e-62 194.0 COG2259@1|root,COG2259@2|Bacteria,1RKEE@1224|Proteobacteria,42SF5@68525|delta/epsilon subdivisions,2YPGK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DoxX family - - - ko:K15977 - - - - ko00000 - - - DoxX k59_731801_1 396588.Tgr7_2896 1.49e-87 264.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1WW0T@135613|Chromatiales 135613|Chromatiales E PFAM Methylenetetrahydrofolate reductase - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1026374_1 765911.Thivi_1397 2.39e-75 251.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJE@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_178150_1 749222.Nitsa_0432 8.77e-14 67.0 2B3E9@1|root,31W34@2|Bacteria,1MZ95@1224|Proteobacteria,42U85@68525|delta/epsilon subdivisions,2YQ41@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_765270_1 768670.Calni_1110 8.82e-50 172.0 COG1690@1|root,COG1690@2|Bacteria,2GFUG@200930|Deferribacteres 200930|Deferribacteres S tRNA-splicing ligase RtcB - - - - - - - - - - - - RtcB k59_111923_1 314230.DSM3645_23671 2.97e-24 107.0 COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,2IXQA@203682|Planctomycetes 203682|Planctomycetes NT Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_4,PAS_9 k59_210612_1 1125863.JAFN01000001_gene771 2.84e-69 234.0 COG0464@1|root,COG0466@1|root,COG0464@2|Bacteria,COG0466@2|Bacteria,1R9P6@1224|Proteobacteria,42PYU@68525|delta/epsilon subdivisions,2WJW7@28221|Deltaproteobacteria 28221|Deltaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,Lon_C k59_635376_1 377629.TERTU_2092 2.27e-84 271.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,1RMP7@1236|Gammaproteobacteria,2PMRK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S HipA-like C-terminal domain - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_635376_2 563192.HMPREF0179_03345 6.7e-09 57.4 COG1396@1|root,COG1396@2|Bacteria,1NGG5@1224|Proteobacteria,42XQ8@68525|delta/epsilon subdivisions,2WT94@28221|Deltaproteobacteria,2MFMH@213115|Desulfovibrionales 28221|Deltaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_635376_3 1123326.JFBL01000020_gene2659 1.01e-74 230.0 COG3467@1|root,COG3467@2|Bacteria,1NEP5@1224|Proteobacteria,42TH0@68525|delta/epsilon subdivisions 1224|Proteobacteria K Putative FMN-binding domain - - - ko:K07005 - - - - ko00000 - - - Acetyltransf_1,Pyridox_ox_2 k59_635376_4 1122134.KB893650_gene512 8.33e-34 119.0 COG2329@1|root,COG2329@2|Bacteria,1N062@1224|Proteobacteria,1S9PR@1236|Gammaproteobacteria,1XKPX@135619|Oceanospirillales 135619|Oceanospirillales H enzyme involved in biosynthesis of extracellular polysaccharides - - - - - - - - - - - - ABM k59_405669_2 1046627.BZARG_1772 3.98e-17 82.0 COG2132@1|root,COG2132@2|Bacteria,4NE3N@976|Bacteroidetes,1HWXY@117743|Flavobacteriia 976|Bacteroidetes Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_307085_1 879212.DespoDRAFT_00374 2.49e-25 102.0 COG0420@1|root,COG0420@2|Bacteria,1MVV6@1224|Proteobacteria,42PFX@68525|delta/epsilon subdivisions,2WJS3@28221|Deltaproteobacteria,2MHR3@213118|Desulfobacterales 28221|Deltaproteobacteria L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,SbcD_C k59_307085_2 1156937.MFUM_310009 4.25e-104 323.0 COG0433@1|root,COG0433@2|Bacteria,46WEP@74201|Verrucomicrobia 74201|Verrucomicrobia S Domain of unknown function DUF87 - - - - - - - - - - - - DUF87 k59_669295_2 323848.Nmul_A0724 2.31e-46 162.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2VJGZ@28216|Betaproteobacteria,372GB@32003|Nitrosomonadales 28216|Betaproteobacteria M Transglycosylase SLT domain mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_700913_1 1121904.ARBP01000017_gene5079 5.69e-23 98.6 COG3507@1|root,COG3507@2|Bacteria,4NGA5@976|Bacteroidetes,47K5U@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0046556,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 k59_217606_28 1049564.TevJSym_ba00350 0.0 1050.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_217606_29 1337093.MBE-LCI_3049 1.36e-05 45.4 COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,2UJFJ@28211|Alphaproteobacteria,2P98P@245186|Loktanella 28211|Alphaproteobacteria P Cytochrome oxidase maturation protein cbb3-type - - - - - - - - - - - - FixS k59_217606_30 1049564.TevJSym_ba00330 1.47e-57 189.0 2DB6R@1|root,2Z7I2@2|Bacteria,1R7AG@1224|Proteobacteria,1RQ0D@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_217606_33 1049564.TevJSym_af00690 0.0 891.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,1RNTD@1236|Gammaproteobacteria,1J9TP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short_C2 k59_217606_34 1297863.APJF01000010_gene3239 4.41e-12 66.6 COG5342@1|root,COG5342@2|Bacteria,1R6BT@1224|Proteobacteria,2U1ZG@28211|Alphaproteobacteria,3JTCZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Invasion associated locus B (IalB) protein ialB - - - - - - - - - - - IalB k59_217606_35 641526.ADIWIN_1217 4.27e-35 134.0 COG0398@1|root,COG0398@2|Bacteria,4NIT2@976|Bacteroidetes,1HY5E@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_217606_36 1049564.TevJSym_au00430 2.3e-204 589.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1J524@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_217606_37 396588.Tgr7_0954 9.04e-54 181.0 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1WXQH@135613|Chromatiales 135613|Chromatiales Q PFAM methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_217606_38 322710.Avin_29600 9.3e-72 219.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_217606_39 1268239.PALB_26090 1.06e-97 291.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,2Q0H4@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.1.26.4 ko:K02342,ko:K14159 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_H,RNase_T k59_217606_40 491952.Mar181_1722 1.85e-68 218.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1XHPV@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator anr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_217606_41 1049564.TevJSym_au00490 2.28e-312 860.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1J4XM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3323,iPC815.YPO3377 CTP_synth_N,GATase k59_217606_42 187272.Mlg_1840 3.46e-154 437.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_119027_1 1168034.FH5T_20490 2.97e-95 296.0 COG1629@1|root,COG4771@2|Bacteria,4PKB3@976|Bacteroidetes 976|Bacteroidetes P receptor - - - - - - - - - - - - TonB_dep_Rec k59_675516_1 709032.Sulku_0109 5.09e-27 100.0 COG0291@1|root,COG0291@2|Bacteria,1QDQ4@1224|Proteobacteria,42VSG@68525|delta/epsilon subdivisions,2YQAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_675516_2 367737.Abu_0074 5.62e-63 194.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,42REF@68525|delta/epsilon subdivisions,2YP4V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_675517_1 1121405.dsmv_0649 4.25e-70 226.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2MI9P@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM,DctQ k59_576661_1 580332.Slit_0815 2.37e-103 314.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VMTA@28216|Betaproteobacteria 28216|Betaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM,DctQ k59_675529_1 1121405.dsmv_0951 3.71e-117 354.0 COG0318@1|root,COG0318@2|Bacteria,1R5I6@1224|Proteobacteria,42MKC@68525|delta/epsilon subdivisions,2WK3U@28221|Deltaproteobacteria,2MI82@213118|Desulfobacterales 28221|Deltaproteobacteria IQ AMP-binding enzyme - - 6.1.3.1 ko:K22319 - - - - ko00000,ko01000 - - - AMP-binding k59_801647_1 1453505.JASY01000010_gene4008 1.16e-15 81.6 COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,1HZEZ@117743|Flavobacteriia,2NS9E@237|Flavobacterium 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_869932_1 1165841.SULAR_07765 2.14e-98 295.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2YMMK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_185155_1 1033730.CAHG01000012_gene2233 6.81e-16 82.4 COG3250@1|root,COG3250@2|Bacteria,2I8XI@201174|Actinobacteria,4DVDQ@85009|Propionibacteriales 201174|Actinobacteria G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_380337_1 631362.Thi970DRAFT_01115 5.29e-76 241.0 28HU5@1|root,2Z80X@2|Bacteria,1R55N@1224|Proteobacteria,1RMAG@1236|Gammaproteobacteria,1WWIS@135613|Chromatiales 135613|Chromatiales S TIGRFAM TIGR03790 family protein - - - - - - - - - - - - - k59_85979_1 314254.OA2633_11575 8.62e-41 156.0 COG3210@1|root,COG3468@1|root,COG3210@2|Bacteria,COG3468@2|Bacteria,1MVQ6@1224|Proteobacteria,2UAUP@28211|Alphaproteobacteria,43X79@69657|Hyphomonadaceae 28211|Alphaproteobacteria MU TIGRFAM outer membrane autotransporter barrel domain - - - - - - - - - - - - Autotransporter,Calx-beta k59_576697_1 1168034.FH5T_06625 4.04e-130 399.0 COG2197@1|root,COG2197@2|Bacteria,4PKSX@976|Bacteroidetes,2FMGR@200643|Bacteroidia 976|Bacteroidetes KT COG NOG11230 non supervised orthologous group - - - - - - - - - - - - GerE,Y_Y_Y k59_869945_1 491205.JARQ01000002_gene53 7.01e-77 254.0 COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,1HWMP@117743|Flavobacteriia,3ZQI6@59732|Chryseobacterium 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_477809_1 526218.Sterm_0694 5.04e-63 202.0 COG1802@1|root,COG1802@2|Bacteria,37AT1@32066|Fusobacteria 32066|Fusobacteria K Transcriptional regulator, GntR family - - - - - - - - - - - - FCD,GntR k59_642304_1 1408473.JHXO01000006_gene1133 7.38e-101 310.0 COG0443@1|root,COG0443@2|Bacteria,4NERF@976|Bacteroidetes,2FMNH@200643|Bacteroidia 976|Bacteroidetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_738439_1 459495.SPLC1_S371110 3.52e-37 143.0 COG0438@1|root,COG0457@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,1FZUY@1117|Cyanobacteria,1HI7Q@1150|Oscillatoriales 1117|Cyanobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,TPR_11,TPR_2,TPR_7,TPR_8 k59_348965_1 488538.SAR116_2366 1.53e-56 186.0 COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,2VAXC@28211|Alphaproteobacteria,4BR8Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Phytanoyl-CoA dioxygenase (PhyH) - - 1.14.11.18 ko:K00477 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - PhyH k59_152639_1 1123399.AQVE01000019_gene1570 5.78e-63 215.0 COG4191@1|root,COG4191@2|Bacteria,1R969@1224|Proteobacteria 1224|Proteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_8 k59_576706_2 349124.Hhal_2433 4.46e-26 101.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1WY1N@135613|Chromatiales 135613|Chromatiales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_119069_2 1388763.O165_028780 5.33e-150 437.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1YXP5@136845|Pseudomonas putida group 1236|Gammaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_801671_2 394503.Ccel_1332 5.67e-42 144.0 COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,36ECT@31979|Clostridiaceae 186801|Clostridia H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK k59_642317_1 398767.Glov_1680 1.44e-19 91.7 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria 28221|Deltaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_544325_1 519989.ECTPHS_06212 3.4e-105 325.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1WWEX@135613|Chromatiales 135613|Chromatiales S PFAM ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_544325_2 395494.Galf_0785 1.86e-61 203.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,44WBE@713636|Nitrosomonadales 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_642319_1 519989.ECTPHS_05561 1.71e-91 302.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1001826_1 1392486.JIAF01000001_gene326 9.91e-11 65.9 COG2214@1|root,COG2214@2|Bacteria,4NZST@976|Bacteroidetes,2FQX2@200643|Bacteroidia 976|Bacteroidetes O DnaJ molecular chaperone homology domain - - - - - - - - - - - - - k59_968653_1 765913.ThidrDRAFT_0290 4.5e-69 234.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_119085_1 883.DvMF_1486 1.96e-51 177.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,42MQV@68525|delta/epsilon subdivisions,2WIZC@28221|Deltaproteobacteria,2MA57@213115|Desulfovibrionales 28221|Deltaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_772493_1 78245.Xaut_4315 1.25e-84 276.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3EYWG@335928|Xanthobacteraceae 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_478674_1 305900.GV64_22810 3.76e-89 282.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1XHJZ@135619|Oceanospirillales 135619|Oceanospirillales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_773343_1 1123373.ATXI01000010_gene1044 8.14e-86 265.0 COG0082@1|root,COG0082@2|Bacteria,2GGRE@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_513476_1 709032.Sulku_1568 3.2e-130 385.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2YMS0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_153522_1 889378.Spiaf_1745 5.53e-61 197.0 COG1018@1|root,COG1018@2|Bacteria 2|Bacteria C nitric oxide dioxygenase activity fpr GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364,iYL1228.KPN_04002 FAD_binding_6,NAD_binding_1 k59_478675_1 1168034.FH5T_04195 8.58e-78 233.0 COG0080@1|root,COG0080@2|Bacteria,4NM60@976|Bacteroidetes,2FRYX@200643|Bacteroidia 976|Bacteroidetes J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_478675_2 1168034.FH5T_04190 3.08e-61 193.0 COG0081@1|root,COG0081@2|Bacteria,4NEIC@976|Bacteroidetes,2FNKI@200643|Bacteroidia 976|Bacteroidetes J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_870837_1 1056820.KB900633_gene2106 1.03e-41 146.0 COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,1S4JK@1236|Gammaproteobacteria,2PQ94@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_870837_2 1255043.TVNIR_0150 4.29e-36 127.0 COG0599@1|root,COG2146@1|root,COG0599@2|Bacteria,COG2146@2|Bacteria,1RCCG@1224|Proteobacteria 1224|Proteobacteria P Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD,Rieske k59_1002754_1 1123257.AUFV01000001_gene1466 1.11e-47 172.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1X3BD@135614|Xanthomonadales 135614|Xanthomonadales E Transglutaminase/protease-like homologues - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_802650_1 1041930.Mtc_2360 5.56e-30 118.0 COG0002@1|root,arCOG00495@2157|Archaea,2XTC1@28890|Euryarchaeota,2N9EF@224756|Methanomicrobia 224756|Methanomicrobia E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_773351_1 391009.Tmel_0306 4.03e-99 296.0 COG0863@1|root,COG0863@2|Bacteria,2GDZW@200918|Thermotogae 200918|Thermotogae L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_838701_1 1123511.KB905839_gene353 9.98e-54 182.0 COG1653@1|root,COG1653@2|Bacteria,1TS9Z@1239|Firmicutes,4H53C@909932|Negativicutes 909932|Negativicutes G Bacterial extracellular solute-binding protein - - - ko:K17234 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - SBP_bac_1 k59_86935_1 439235.Dalk_0385 1.22e-25 107.0 COG1148@1|root,COG1148@2|Bacteria,1R9EV@1224|Proteobacteria,42PIR@68525|delta/epsilon subdivisions,2WK4U@28221|Deltaproteobacteria 2|Bacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein hdrA - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388,ko:K16885,ko:K16886 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Pyr_redox_2 k59_904121_1 326298.Suden_0006 4.48e-102 312.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_120135_1 1266914.ATUK01000015_gene884 3.17e-101 308.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_86936_1 351348.Maqu_2228 1.06e-86 279.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,464AD@72275|Alteromonadaceae 1236|Gammaproteobacteria I Belongs to the GPAT DAPAT family plsB GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - iECs_1301.ECs5024,iG2583_1286.G2583_4866 Acyltransferase k59_478698_1 768671.ThimaDRAFT_0670 2.9e-75 240.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,1WXKJ@135613|Chromatiales 135613|Chromatiales S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 k59_52396_1 1123234.AUKI01000011_gene1473 1.35e-12 73.2 COG2382@1|root,COG2382@2|Bacteria,4NF50@976|Bacteroidetes,1HWW6@117743|Flavobacteriia 976|Bacteroidetes P esterase - - - ko:K07214 - - - - ko00000 - - - Esterase,SASA k59_86939_1 1121012.AUKX01000005_gene3602 1.6e-16 80.9 COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,1HZEZ@117743|Flavobacteriia,23FQF@178469|Arenibacter 976|Bacteroidetes T Y_Y_Y domain - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_1034108_1 1121121.KB894309_gene1756 1.41e-36 142.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae 91061|Bacilli Q Non-ribosomal peptide synthetase modules and related proteins nrsB - - ko:K16094,ko:K16095 ko01054,map01054 - - - ko00000,ko00001 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_838709_1 748247.AZKH_1105 1.81e-50 171.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,2VKYR@28216|Betaproteobacteria,2KW1I@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HDOD k59_838709_2 1238182.C882_2377 1.89e-33 121.0 COG2010@1|root,COG2010@2|Bacteria,1NAGW@1224|Proteobacteria,2UCCK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG2010 Cytochrome c, mono- and diheme variants - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_870863_1 866775.HMPREF9243_0176 5e-171 506.0 COG1061@1|root,COG3587@1|root,COG1061@2|Bacteria,COG3587@2|Bacteria,1UQNX@1239|Firmicutes,4HBXT@91061|Bacilli 91061|Bacilli KL type III restriction enzyme, res subunit - - 3.1.21.5 ko:K01156 - - - - ko00000,ko01000,ko02048 - - - Helicase_C,ResIII k59_478706_2 637910.ROD_30631 8.3e-61 192.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,3WVKU@544|Citrobacter 1236|Gammaproteobacteria H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016849,GO:0030145,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3360 YgbB k59_1034112_1 1267534.KB906754_gene3219 1.8e-15 81.6 COG0421@1|root,COG0421@2|Bacteria,3Y6UP@57723|Acidobacteria 57723|Acidobacteria E Spermine/spermidine synthase domain - - - - - - - - - - - - Spermine_synth k59_86948_1 1168067.JAGP01000001_gene1843 3.48e-26 104.0 COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,1S2AY@1236|Gammaproteobacteria,461E6@72273|Thiotrichales 72273|Thiotrichales T Phosphoglycerate mutase family - - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_86948_2 644076.SCH4B_2808 5.91e-41 148.0 COG0391@1|root,COG0391@2|Bacteria,1NW3K@1224|Proteobacteria,2U1VR@28211|Alphaproteobacteria,4NDAG@97050|Ruegeria 28211|Alphaproteobacteria S Uncharacterised protein family UPF0052 - - - - - - - - - - - - UPF0052 k59_1034114_1 709032.Sulku_0437 2.64e-29 108.0 COG1539@1|root,COG1539@2|Bacteria,1RHII@1224|Proteobacteria,42V1R@68525|delta/epsilon subdivisions,2YQ8Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H dihydroneopterin aldolase folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_1034114_2 1537917.JU82_08000 1.76e-103 303.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,42QQP@68525|delta/epsilon subdivisions,2YNZZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_16651_1 903818.KI912268_gene685 3.35e-137 415.0 COG3968@1|root,COG3968@2|Bacteria,3Y9EM@57723|Acidobacteria 57723|Acidobacteria S Glutamine synthetase type III N terminal - - - - - - - - - - - - GSIII_N,Gln-synt_C k59_16651_2 290397.Adeh_3508 7.29e-19 84.7 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,42S1N@68525|delta/epsilon subdivisions,2WNUH@28221|Deltaproteobacteria,2Z1FH@29|Myxococcales 28221|Deltaproteobacteria O Thioredoxin trx-3 - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin k59_513536_1 762963.HMPREF9056_00526 6.9e-06 50.1 COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4D3KS@85005|Actinomycetales 201174|Actinobacteria E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_513536_2 1499967.BAYZ01000029_gene1212 4.38e-54 181.0 COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria 2|Bacteria E Arginosuccinate synthase argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.argG,iSB619.SA_RS04675 Arginosuc_synth k59_381354_1 550540.Fbal_1135 4.24e-73 233.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E oxidoreductase ordL GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO k59_1034123_1 944547.ABLL_0012 2.3e-106 320.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions 1224|Proteobacteria KT PFAM sigma-54 factor interaction domain-containing protein nifA - - ko:K02584,ko:K12266 ko02020,ko05132,map02020,map05132 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_513543_1 1165841.SULAR_07460 1.1e-97 296.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,42MQ3@68525|delta/epsilon subdivisions,2YMPC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_315003_1 536233.CLO_0467 5.28e-17 84.0 COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1TRZ0@1239|Firmicutes,25EW7@186801|Clostridia,36US9@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_186194_1 1267533.KB906733_gene3283 5.6e-21 99.0 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - FMN_bind,PG_binding_1 k59_455473_2 1280001.BAOA01000048_gene1854 4.24e-05 47.4 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1XXWR@135623|Vibrionales 135623|Vibrionales J COG1544 Ribosome-associated protein Y (PSrp-1) yhbH - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_455473_3 572544.Ilyop_1107 7.11e-154 436.0 COG0428@1|root,COG0428@2|Bacteria,379W9@32066|Fusobacteria 32066|Fusobacteria P ZIP Zinc transporter - - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - Zip k59_455473_4 1123274.KB899432_gene2918 2.83e-35 126.0 COG1762@1|root,COG1762@2|Bacteria,2J5KE@203691|Spirochaetes 203691|Spirochaetes G DNA-binding protein PTS system, IIA component - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - HTH_17,PTS_EIIA_2 k59_455473_5 158190.SpiGrapes_2308 3.35e-63 211.0 COG0475@1|root,COG0475@2|Bacteria,2J5WC@203691|Spirochaetes 203691|Spirochaetes P Sodium hydrogen exchanger family - - - - - - - - - - - - CBS,Na_H_Exchanger k59_1042821_2 1265505.ATUG01000001_gene4389 3.15e-36 130.0 COG1595@1|root,COG1595@2|Bacteria,1PEU8@1224|Proteobacteria,42T76@68525|delta/epsilon subdivisions,2WPVH@28221|Deltaproteobacteria,2MM35@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_554203_1 876044.IMCC3088_2044 1.07e-133 396.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,1J4SZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_258353_1 987059.RBXJA2T_15488 1.3e-93 278.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,1KK3M@119065|unclassified Burkholderiales 28216|Betaproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_684598_1 580332.Slit_1609 4.58e-117 340.0 COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria,2VI6U@28216|Betaproteobacteria,44W9N@713636|Nitrosomonadales 28216|Betaproteobacteria C PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding hoxU - 1.12.1.2 ko:K18006 - - - - ko00000,ko01000 - - - Fer2_4,Fer4_15,NADH-G_4Fe-4S_3 k59_684599_1 1417296.U879_20705 1.72e-58 189.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,2UIT4@28211|Alphaproteobacteria 28211|Alphaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_810821_1 363253.LI0135 2.4e-08 57.0 COG4641@1|root,COG4641@2|Bacteria,1R4AN@1224|Proteobacteria,42PZP@68525|delta/epsilon subdivisions,2WJGG@28221|Deltaproteobacteria,2M8D1@213115|Desulfovibrionales 28221|Deltaproteobacteria S DUF based on E. rectale Gene description (DUF3880) - - - ko:K06320 - - - - ko00000 - - - DUF3880,Glyco_trans_1_2 k59_357626_1 1235457.C404_08795 1.06e-45 155.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,1K0NX@119060|Burkholderiaceae 28216|Betaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_945627_2 644107.SL1157_1941 4.26e-25 96.7 COG3062@1|root,COG3062@2|Bacteria,1NGMR@1224|Proteobacteria,2UJYV@28211|Alphaproteobacteria,4NCJA@97050|Ruegeria 28211|Alphaproteobacteria P NapD protein napD - - ko:K02570 - - - - ko00000 - - - NapD k59_945627_3 1238182.C882_3696 5.68e-18 80.1 COG1145@1|root,COG1145@2|Bacteria,1N09Y@1224|Proteobacteria,2UD4I@28211|Alphaproteobacteria,2JTKZ@204441|Rhodospirillales 204441|Rhodospirillales C 4Fe-4S dicluster domain - - - - - - - - - - - - - k59_651084_1 1415780.JPOG01000001_gene875 6.85e-82 270.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5MD@135614|Xanthomonadales 135614|Xanthomonadales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_60931_1 1537917.JU82_08650 1.2e-105 317.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2YN6C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidase U32 family prtC - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_846458_1 338969.Rfer_1353 1.81e-147 426.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,4ABMU@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_226745_1 402881.Plav_2126 3.51e-72 236.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,1JNCB@119043|Rhodobiaceae 28211|Alphaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_651087_1 765912.Thimo_2109 3.06e-102 323.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_322142_1 1031711.RSPO_c02847 3.59e-69 228.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae 28216|Betaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_977605_2 555778.Hneap_1360 1.39e-11 71.2 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,1S5E8@1236|Gammaproteobacteria,1WYJF@135613|Chromatiales 135613|Chromatiales Q PFAM Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_322146_1 452637.Oter_0509 5.31e-29 119.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - - - - - - - - - - OEP k59_619097_1 1123354.AUDR01000013_gene634 2.28e-89 267.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,1KS0G@119069|Hydrogenophilales 119069|Hydrogenophilales F Queuosine biosynthesis protein QueC - - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_486100_1 870187.Thini_2547 7.02e-74 247.0 COG4188@1|root,COG4188@2|Bacteria,1QUVG@1224|Proteobacteria,1T22C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1073 Hydrolases of the alpha beta superfamily - - - - - - - - - - - - Lipase_bact_N,PAF-AH_p_II k59_162415_1 349124.Hhal_0004 5.33e-24 100.0 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1WXUQ@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k59_162415_2 454957.IA64_19085 2.68e-64 209.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X55Q@135614|Xanthomonadales 135614|Xanthomonadales EH component I pabB - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_95018_1 1121937.AUHJ01000009_gene1506 8.36e-65 212.0 COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,1RNBE@1236|Gammaproteobacteria,469FG@72275|Alteromonadaceae 1236|Gammaproteobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_95018_2 1049564.TevJSym_bc00390 1.54e-179 514.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Nickel-dependent hydrogenase hydB - 1.12.5.1,1.12.99.6 ko:K05922,ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_322161_1 1049564.TevJSym_ab00790 9e-54 184.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RPMH@1236|Gammaproteobacteria,1J85K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_619107_1 1123326.JFBL01000022_gene2633 1.31e-146 432.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2YP81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_226786_1 382464.ABSI01000011_gene2618 2.38e-78 245.0 COG0668@1|root,COG0668@2|Bacteria,46V1Y@74201|Verrucomicrobia,2IUI5@203494|Verrucomicrobiae 203494|Verrucomicrobiae M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel,TM_helix k59_810862_1 913325.N799_00765 4.86e-59 194.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1X3FF@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mexA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD,HlyD_D23 k59_810862_2 762983.HMPREF9444_00493 0.00016 43.1 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1Y3W3@135624|Aeromonadales 135624|Aeromonadales V Efflux pump membrane transporter - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_846499_1 1121405.dsmv_2119 3.14e-70 234.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_128048_1 616991.JPOO01000001_gene4607 2.1e-42 159.0 COG3264@1|root,COG3264@2|Bacteria,4PMEF@976|Bacteroidetes,1IJXV@117743|Flavobacteriia 976|Bacteroidetes M Ion channel - - - - - - - - - - - - MS_channel k59_651114_1 179408.Osc7112_3096 4.63e-63 218.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_3,Pkinase,Response_reg k59_322174_1 1242864.D187_006660 1.77e-77 243.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales 28221|Deltaproteobacteria H Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_60977_1 1165841.SULAR_05463 5.03e-110 322.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,42MPM@68525|delta/epsilon subdivisions,2YMX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_619124_1 1122134.KB893650_gene477 5.94e-53 187.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_619124_2 1255043.TVNIR_3739 7.27e-36 128.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria,1WXV0@135613|Chromatiales 135613|Chromatiales S Cytokinin riboside 5'-monophosphate phosphoribohydrolase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_194657_2 1122983.BAJY01000019_gene1109 2.46e-05 53.9 2DRII@1|root,33BYB@2|Bacteria,4PNVB@976|Bacteroidetes,2G0YP@200643|Bacteroidia 976|Bacteroidetes S WG containing repeat - - - - - - - - - - - - WG_beta_rep k59_522165_1 525256.HMPREF0091_10455 1.07e-17 86.3 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CUWF@84998|Coriobacteriia 84998|Coriobacteriia D Belongs to the 'phage' integrase family. XerC subfamily xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_945685_1 1410618.JNKI01000017_gene363 4.98e-25 103.0 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4H466@909932|Negativicutes 909932|Negativicutes T phosphatase prpC - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_289627_1 768671.ThimaDRAFT_0945 6.13e-156 443.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1WWM1@135613|Chromatiales 135613|Chromatiales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_289627_2 2340.JV46_16710 4.14e-76 237.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1J5FZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_289627_3 357804.Ping_2411 3.16e-174 515.0 COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,1RRCA@1236|Gammaproteobacteria 1236|Gammaproteobacteria T EAL domain - - - - - - - - - - - - CBS,EAL,GGDEF k59_289627_4 690850.Desaf_2167 5.12e-38 133.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42RQI@68525|delta/epsilon subdivisions,2WNEC@28221|Deltaproteobacteria,2MBFG@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM Protein-tyrosine phosphatase, low molecular weight arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_289627_6 1123514.KB905902_gene298 1.09e-38 136.0 COG3431@1|root,COG3431@2|Bacteria,1NJ7G@1224|Proteobacteria,1SPW3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphate-starvation-inducible E - - - - - - - - - - - - PsiE k59_289627_7 765913.ThidrDRAFT_2111 6.98e-101 297.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1WWJX@135613|Chromatiales 135613|Chromatiales F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_289627_8 765912.Thimo_1358 1.49e-95 284.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,1WXQD@135613|Chromatiales 135613|Chromatiales O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_289627_9 159087.Daro_3992 1.46e-92 277.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,2KW4C@206389|Rhodocyclales 206389|Rhodocyclales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_289627_10 640081.Dsui_1169 2.01e-136 390.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,2KV1K@206389|Rhodocyclales 206389|Rhodocyclales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_289627_11 557598.LHK_02089 4.72e-09 54.3 COG3114@1|root,COG3114@2|Bacteria 2|Bacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmD GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735 CcmD k59_289627_12 977880.RALTA_B0644 9.94e-43 145.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1K8MK@119060|Burkholderiaceae 28216|Betaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_289627_13 2340.JV46_18390 1.92e-302 844.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cytochrome c-type biogenesis protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_289627_14 1238182.C882_3282 6.21e-44 151.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,2JSVQ@204441|Rhodospirillales 204441|Rhodospirillales CO Redoxin ccmG - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_289627_15 349521.HCH_04362 4.05e-34 124.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1XKQE@135619|Oceanospirillales 135619|Oceanospirillales P subunit of a heme lyase ccmH - - ko:K02200 - - - - ko00000 - - - CcmH k59_289627_16 686340.Metal_1029 4.16e-48 172.0 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1XE56@135618|Methylococcales 135618|Methylococcales O TIGRFAM Cytochrome c-type biogenesis protein CcmI - - - ko:K02200 - - - - ko00000 - - - - k59_289627_17 1278309.KB907099_gene2470 3.83e-91 281.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XH2W@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_289627_18 1049564.TevJSym_bi00080 0.0 1086.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - DUF3365,EAL,GGDEF,PAS_3,PAS_9,Response_reg k59_289627_19 754476.Q7A_3058 1.11e-125 362.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,45ZZN@72273|Thiotrichales 72273|Thiotrichales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_289627_20 1049564.TevJSym_as00350 1.57e-83 260.0 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,1SZE9@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_289627_21 1049564.TevJSym_as00340 8.59e-131 382.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria KLT serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_289627_22 765910.MARPU_16140 1.01e-88 273.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1WX83@135613|Chromatiales 135613|Chromatiales S PFAM YicC-like - - - - - - - - - - - - DUF1732,YicC_N k59_289627_23 243277.VC_2708 3.77e-66 209.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XSI2@135623|Vibrionales 135623|Vibrionales F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_289627_24 768671.ThimaDRAFT_2736 1.9e-32 115.0 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales 135613|Chromatiales K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_289627_25 1049564.TevJSym_ai00970 0.0 903.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J53A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_289627_26 572477.Alvin_2537 1.26e-61 191.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales 135613|Chromatiales J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_289627_27 1049564.TevJSym_ai00880 1.64e-67 207.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1J6EU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein family UPF0047 yjbQ - - - - - - - - - - - UPF0047 k59_289627_28 768671.ThimaDRAFT_1849 7.75e-10 56.2 COG0011@1|root,COG0011@2|Bacteria,1N2GU@1224|Proteobacteria,1S9DG@1236|Gammaproteobacteria,1WYXR@135613|Chromatiales 135613|Chromatiales S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP k59_322200_1 556263.FSEG_00242 1.7e-32 125.0 COG4658@1|root,COG4658@2|Bacteria,378EB@32066|Fusobacteria 32066|Fusobacteria C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_586208_1 1168034.FH5T_00310 8.99e-25 99.0 COG0782@1|root,COG0782@2|Bacteria,4NQAD@976|Bacteroidetes 976|Bacteroidetes K Transcription elongation factor - - - - - - - - - - - - GreA_GreB k59_586208_2 1453505.JASY01000001_gene3618 9.63e-185 518.0 COG3940@1|root,COG3940@2|Bacteria,4NGA6@976|Bacteroidetes,1I0X8@117743|Flavobacteriia,2NZWQ@237|Flavobacterium 976|Bacteroidetes G Glycosyl hydrolases family 43 - - - - - - - - - - - - Glyco_hydro_43 k59_322201_1 1172562.HCN_1491 8.9e-40 146.0 COG0464@1|root,COG0464@2|Bacteria,1N4ZI@1224|Proteobacteria,42NGJ@68525|delta/epsilon subdivisions,2YMAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATPase (AAA - - - - - - - - - - - - AAA k59_716114_1 572477.Alvin_2064 3.22e-82 265.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_357667_1 1168034.FH5T_11585 2.91e-107 317.0 COG5383@1|root,COG5383@2|Bacteria,4NGFT@976|Bacteroidetes 976|Bacteroidetes S DUF1338 - - - - - - - - - - - - DUF1338 k59_289635_1 525146.Ddes_2231 1.1e-109 338.0 COG3972@1|root,COG3972@2|Bacteria,1R42E@1224|Proteobacteria,42VFZ@68525|delta/epsilon subdivisions,2WU2H@28221|Deltaproteobacteria,2MB05@213115|Desulfovibrionales 28221|Deltaproteobacteria S UvrD-like helicase C-terminal domain - - - - - - - - - - - - UvrD_C_2 k59_847168_8 223283.PSPTO_4055 4.29e-05 44.3 2AU6T@1|root,31JTU@2|Bacteria,1QHKP@1224|Proteobacteria,1TFA8@1236|Gammaproteobacteria,1ZADN@136849|Pseudomonas syringae group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_879761_1 1380358.JADJ01000003_gene4715 4.38e-95 288.0 COG3181@1|root,COG3181@2|Bacteria,1R5C8@1224|Proteobacteria,1S1K9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ABC transporter substrate-binding protein - - - - - - - - - - - - - k59_782507_1 1002672.SAR11G3_01390 5.28e-55 180.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,4BQAI@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid k59_227696_1 929558.SMGD1_1222 5.87e-154 449.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,42MYF@68525|delta/epsilon subdivisions,2YMXD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Single-stranded-DNA-specific exonuclease (RecJ) recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_460422_2 572544.Ilyop_0368 8.79e-10 59.3 COG0795@1|root,COG0795@2|Bacteria,378KF@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_656657_1 1537917.JU82_08090 1.44e-46 159.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2YM8W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_656657_2 1123326.JFBL01000001_gene1285 2.42e-204 576.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,42MNG@68525|delta/epsilon subdivisions,2YNM4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation - - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_918125_1 713586.KB900536_gene2985 1.14e-65 215.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1S14K@1236|Gammaproteobacteria,1X0FN@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX2 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_884860_1 765912.Thimo_0093 6.48e-56 195.0 COG0784@1|root,COG4251@1|root,COG0784@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - 4HB_MCP_1,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg k59_754167_1 500635.MITSMUL_05393 1.17e-31 121.0 COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,4H1ZZ@909932|Negativicutes 909932|Negativicutes I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_525722_1 1168034.FH5T_18920 1.47e-84 255.0 COG0543@1|root,COG0543@2|Bacteria,4NE35@976|Bacteroidetes,2FN69@200643|Bacteroidia 976|Bacteroidetes C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_525722_2 1168034.FH5T_18925 3.53e-95 284.0 COG0167@1|root,COG0167@2|Bacteria,4NDVB@976|Bacteroidetes,2FPMW@200643|Bacteroidia 976|Bacteroidetes F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14,1.3.98.1 ko:K00226,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_852665_1 709032.Sulku_1100 5.39e-26 107.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42RH7@68525|delta/epsilon subdivisions 1224|Proteobacteria N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_623630_1 674977.VMC_04800 4.61e-24 100.0 COG0560@1|root,COG0560@2|Bacteria,1RKIX@1224|Proteobacteria,1S7JP@1236|Gammaproteobacteria,1XX2B@135623|Vibrionales 135623|Vibrionales E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD k59_166212_1 765912.Thimo_0894 3.68e-59 199.0 28MTB@1|root,2ZB1J@2|Bacteria,1MWD0@1224|Proteobacteria,1RSK4@1236|Gammaproteobacteria,1WVV5@135613|Chromatiales 135613|Chromatiales S PFAM Type IV conjugative transfer system protein TraH - - - ko:K12072 - - - - ko00000,ko02044 3.A.7.11.1 - - TraH k59_166212_2 1127673.GLIP_0774 3.84e-08 53.9 COG4678@1|root,COG4678@2|Bacteria,1MXCR@1224|Proteobacteria,1RPZR@1236|Gammaproteobacteria 1236|Gammaproteobacteria G PFAM TraG-like protein, N-terminal region - - - ko:K12056 - - - - ko00000,ko02044 3.A.7.11.1 - - TraG_N k59_492951_3 1121935.AQXX01000135_gene3743 1.64e-25 103.0 COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,1S5K2@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methyltransferase type 11 pmtA - 2.1.1.17,2.1.1.71 ko:K00570 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00091 R01320,R02056,R03424 RC00003,RC00060,RC00181,RC00496 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_263828_1 439235.Dalk_2714 1.62e-24 94.0 COG1146@1|root,COG1146@2|Bacteria,1NJJD@1224|Proteobacteria,42VKY@68525|delta/epsilon subdivisions,2WRXE@28221|Deltaproteobacteria,2MKYB@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S ferredoxin, iron-sulfur binding - - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7 k59_263828_2 1121405.dsmv_1296 3.31e-49 166.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MI7P@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Pyruvate flavodoxin ferredoxin oxidoreductase korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_721790_1 1150621.SMUL_2280 3.45e-23 97.1 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,42SQE@68525|delta/epsilon subdivisions,2YPHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0003674,GO:0003824,GO:0004141,GO:0016874,GO:0016879,GO:0016882 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_721790_2 1249480.B649_09230 9.43e-20 87.4 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,42MVB@68525|delta/epsilon subdivisions,2YNU4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E O-acetylhomoserine sulfhydrylase - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_166214_1 99598.Cal7507_4444 6.1e-80 261.0 COG0491@1|root,COG4529@1|root,COG0491@2|Bacteria,COG4529@2|Bacteria,1G0CZ@1117|Cyanobacteria,1HMAK@1161|Nostocales 1117|Cyanobacteria S Hydrolase - - - - - - - - - - - - Lactamase_B,NAD_binding_9 k59_950675_1 1123401.JHYQ01000018_gene2373 9.63e-40 147.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,45ZVB@72273|Thiotrichales 72273|Thiotrichales S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 k59_852667_2 999419.HMPREF1077_02014 2.44e-65 211.0 COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,2FMX2@200643|Bacteroidia,22W77@171551|Porphyromonadaceae 976|Bacteroidetes D Chromosome partitioning protein ParA soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_852667_3 596323.HMPREF0554_0661 1.19e-23 105.0 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_852667_4 596323.HMPREF0554_1155 2.37e-10 60.8 2EMHA@1|root,33F5X@2|Bacteria,37B58@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_918148_1 1453501.JELR01000002_gene344 3.06e-25 101.0 COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,1S3TB@1236|Gammaproteobacteria 1236|Gammaproteobacteria U biopolymer transport protein - - - - - - - - - - - - ExbD k59_100694_1 1165841.SULAR_10539 9.93e-82 264.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2YMH2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_623641_1 1049564.TevJSym_ag00510 7.85e-51 169.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1J4SR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_558498_1 572544.Ilyop_1410 6.1e-176 493.0 COG1348@1|root,COG1348@2|Bacteria,37A8Z@32066|Fusobacteria 32066|Fusobacteria D 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family - - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_558498_2 572544.Ilyop_1409 1.05e-54 172.0 COG0347@1|root,COG0347@2|Bacteria 2|Bacteria K Belongs to the P(II) protein family glnBA - - ko:K02589,ko:K02590,ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_525741_1 96561.Dole_1849 1.33e-95 298.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WJ0I@28221|Deltaproteobacteria,2MIAG@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_133535_1 700598.Niako_1345 3.89e-41 155.0 COG4625@1|root,COG4625@2|Bacteria,4PNU8@976|Bacteroidetes 976|Bacteroidetes S pathogenesis - - - - - - - - - - - - - k59_492964_1 641524.ADICYQ_0219 1.9e-24 104.0 COG4942@1|root,COG4942@2|Bacteria,4NMI2@976|Bacteroidetes 976|Bacteroidetes D peptidase - - - - - - - - - - - - - k59_689104_1 4081.Solyc06g060030.1.1 1.01e-42 157.0 COG2801@1|root,KOG0017@2759|Eukaryota,37THH@33090|Viridiplantae,3GG2K@35493|Streptophyta,44UC5@71274|asterids 35493|Streptophyta L Mitochondrial protein - - - - - - - - - - - - RVT_2,Retrotran_gag_2,Retrotran_gag_3,Retrotrans_gag,gag_pre-integrs,rve,zf-CCHC k59_296736_1 1168034.FH5T_17480 5.76e-109 331.0 COG3501@1|root,COG3501@2|Bacteria,4NFPB@976|Bacteroidetes,2FPUE@200643|Bacteroidia 976|Bacteroidetes S Rhs element Vgr protein - - - - - - - - - - - - Phage_GPD k59_656708_1 933262.AXAM01000015_gene75 5.64e-74 229.0 COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,42QAW@68525|delta/epsilon subdivisions,2WIXS@28221|Deltaproteobacteria,2MIY5@213118|Desulfobacterales 28221|Deltaproteobacteria D Belongs to the ParA family minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_656708_2 1304885.AUEY01000002_gene328 2.63e-29 107.0 COG0851@1|root,COG0851@2|Bacteria,1N0Z7@1224|Proteobacteria,42TYJ@68525|delta/epsilon subdivisions,2WQAJ@28221|Deltaproteobacteria,2MKG6@213118|Desulfobacterales 28221|Deltaproteobacteria D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE k59_329716_1 1121403.AUCV01000041_gene158 3.41e-90 283.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.12.1.3,1.6.5.2,1.6.5.3 ko:K00124,ko:K00335,ko:K00355,ko:K18331 ko00130,ko00190,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,ko05200,ko05225,ko05418,map00130,map00190,map00630,map00680,map01100,map01110,map01120,map01200,map05200,map05225,map05418 M00144 R00519,R02964,R03643,R03816,R11945 RC00061,RC00819,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_590940_1 1123257.AUFV01000014_gene3362 7.36e-17 74.3 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria,1X6Y2@135614|Xanthomonadales 135614|Xanthomonadales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control ihfA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_590940_2 187272.Mlg_0763 2.83e-53 189.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales 135613|Chromatiales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_35542_2 1121405.dsmv_3080 7.28e-21 88.6 COG5403@1|root,COG5403@2|Bacteria,1PY2R@1224|Proteobacteria,42Y17@68525|delta/epsilon subdivisions 1224|Proteobacteria S PFAM Bacterial protein of - - - - - - - - - - - - DUF937 k59_330377_1 1168034.FH5T_04460 2.82e-105 311.0 COG0324@1|root,COG0324@2|Bacteria,4NFJY@976|Bacteroidetes,2FM0H@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA2 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_722383_1 326427.Cagg_2702 3.91e-66 222.0 COG0205@1|root,COG0205@2|Bacteria,2G62R@200795|Chloroflexi,375FT@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis - - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_167030_1 1123326.JFBL01000006_gene982 9.67e-34 131.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2YMFV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_167030_2 1242969.ATCC51562_1822 5.66e-32 122.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2YMAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_493687_2 1232437.KL662015_gene1255 1.03e-26 110.0 COG2909@1|root,COG3187@1|root,COG2909@2|Bacteria,COG3187@2|Bacteria 2|Bacteria O response to heat - - - ko:K03668,ko:K03929 - - - - ko00000,ko01000 - CE10 - GerE,META k59_722385_1 1168034.FH5T_09470 2.21e-36 134.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,2FQ0Q@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_722385_2 869213.JCM21142_104363 7.42e-87 265.0 2CJZ2@1|root,32SB4@2|Bacteria,4NSR3@976|Bacteroidetes 976|Bacteroidetes S non supervised orthologous group - - - - - - - - - - - - NigD_C,NigD_N k59_297303_1 1202962.KB907172_gene2562 6.06e-223 629.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria 1236|Gammaproteobacteria E alanine symporter agcS_1 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_885448_1 134676.ACPL_3498 3.23e-41 158.0 COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria,4DAHT@85008|Micromonosporales 201174|Actinobacteria U Type IV secretory pathway, VirB4 - - - - - - - - - - - - AAA_10,DUF87,PrgI k59_461220_1 1168034.FH5T_09310 3.19e-121 355.0 COG0451@1|root,COG0451@2|Bacteria,4NFZH@976|Bacteroidetes,2FS6N@200643|Bacteroidia 976|Bacteroidetes M NAD(P)H-binding - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase,NAD_binding_4 k59_983743_1 1168034.FH5T_12060 1.23e-103 314.0 COG3104@1|root,COG3104@2|Bacteria,4NE8R@976|Bacteroidetes,2FNB6@200643|Bacteroidia 976|Bacteroidetes P amino acid peptide transporter - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_657477_2 1168034.FH5T_06740 9.2e-118 345.0 COG0438@1|root,COG0438@2|Bacteria,4NETA@976|Bacteroidetes,2FPWJ@200643|Bacteroidia 976|Bacteroidetes M Psort location Cytoplasmic, score - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1016521_1 1165841.SULAR_06858 4.1e-35 132.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2YNTT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,TPR_8,VWA_2 k59_526500_1 1094508.Tsac_0168 7.99e-100 302.0 COG4225@1|root,COG4225@2|Bacteria,1TRJ7@1239|Firmicutes,24806@186801|Clostridia,42I40@68295|Thermoanaerobacterales 186801|Clostridia S PFAM glycosyl hydrolase family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_526500_2 1319815.HMPREF0202_02216 1.87e-104 317.0 COG1653@1|root,COG1653@2|Bacteria,379A1@32066|Fusobacteria 32066|Fusobacteria G Bacterial extracellular solute-binding protein - - - ko:K10192 ko02010,map02010 M00202 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.11 - - SBP_bac_8 k59_134284_1 411902.CLOBOL_07079 3.69e-74 240.0 COG2211@1|root,COG2211@2|Bacteria,1TSEH@1239|Firmicutes,25MPI@186801|Clostridia,21YWX@1506553|Lachnoclostridium 186801|Clostridia G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_167061_1 768671.ThimaDRAFT_1692 2.74e-104 312.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,1WWQR@135613|Chromatiales 135613|Chromatiales E PFAM Cys Met metabolism - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_362741_1 765910.MARPU_07530 5.37e-30 125.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2RK@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - CHASE,HAMP,HATPase_c,HisKA,Hpt,MASE1,PAS_3,PAS_9,Response_reg k59_526505_1 13333.ERN02872 1.08e-193 545.0 COG0055@1|root,KOG1350@2759|Eukaryota,37K5M@33090|Viridiplantae,3GCIP@35493|Streptophyta 35493|Streptophyta C ATP synthase subunit beta atpB - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_885468_1 1397666.RS24_01767 2.51e-88 278.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,4BPNS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_820456_1 1168034.FH5T_10865 1.01e-100 309.0 COG0187@1|root,COG0187@2|Bacteria,4NF18@976|Bacteroidetes,2FMMD@200643|Bacteroidia 976|Bacteroidetes L DNA topoisomerase parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_820456_2 1168034.FH5T_10870 7.32e-121 369.0 COG0188@1|root,COG0188@2|Bacteria,4NERI@976|Bacteroidetes,2FPAU@200643|Bacteroidia 976|Bacteroidetes L Belongs to the type II topoisomerase GyrA ParC subunit family parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_topoisoIV k59_1016534_1 351348.Maqu_2844 1.69e-73 228.0 COG1024@1|root,COG1024@2|Bacteria,1R3Q4@1224|Proteobacteria,1RQ45@1236|Gammaproteobacteria,46CP5@72275|Alteromonadaceae 1236|Gammaproteobacteria I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_624344_1 272942.RCAP_rcc00179 9.73e-109 323.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TTE1@28211|Alphaproteobacteria,1FB1M@1060|Rhodobacter 28211|Alphaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_2267_1 709032.Sulku_2223 1.51e-12 66.2 COG1123@1|root,COG1123@2|Bacteria,1QXRI@1224|Proteobacteria,43CKN@68525|delta/epsilon subdivisions,2YTDT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Abc transporter - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran k59_2267_2 387093.SUN_0349 1.22e-46 162.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2YN3A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E 8-amino-7-oxononanoate synthase bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_493715_1 768671.ThimaDRAFT_3701 1.33e-10 61.2 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1X0CI@135613|Chromatiales 135613|Chromatiales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_493715_2 62928.azo2353 3.43e-80 239.0 COG0394@1|root,COG0394@2|Bacteria,1REU2@1224|Proteobacteria,2VS5B@28216|Betaproteobacteria 28216|Betaproteobacteria T Low molecular weight phosphatase family - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_493715_3 1123393.KB891329_gene945 1.98e-224 622.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,1KSTF@119069|Hydrogenophilales 119069|Hydrogenophilales P Sodium Bile acid symporter family - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_134286_1 1168034.FH5T_11660 6.11e-74 233.0 COG2866@1|root,COG2866@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity - - - - - - - - - - - - DUF2817,Peptidase_M14 k59_134286_2 1168034.FH5T_11665 8.06e-162 468.0 COG5505@1|root,COG5505@2|Bacteria,4NPE1@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF819) - - - - - - - - - - - - DUF819 k59_232168_1 1193729.A1OE_1496 3.39e-05 54.3 COG0236@1|root,COG0300@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG0300@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3321 Polyketide synthase modules and related proteins - - - ko:K04786,ko:K13613,ko:K13614 ko01053,map01053 - - - ko00000,ko00001,ko01004,ko01008 - - - ACPS,AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,NMO,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_890359_2 1117319.PSPO_03675 6.65e-12 63.2 COG0236@1|root,COG0236@2|Bacteria,1NEMA@1224|Proteobacteria,1T0FU@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_955703_2 1122951.ATUE01000006_gene1471 1.15e-93 293.0 COG0477@1|root,COG0477@2|Bacteria,1QU36@1224|Proteobacteria,1T2WT@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP TIGRFAM Drug resistance transporter Bcr CflA subfamily bcr - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_139841_1 883.DvMF_1160 1e-28 119.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,42MP9@68525|delta/epsilon subdivisions,2WJWN@28221|Deltaproteobacteria,2M98S@213115|Desulfovibrionales 28221|Deltaproteobacteria V PFAM ABC transporter - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_336035_1 1168034.FH5T_05710 2.83e-22 95.5 COG0617@1|root,COG0617@2|Bacteria,4NF1S@976|Bacteroidetes,2FNMZ@200643|Bacteroidia 976|Bacteroidetes J tRNA nucleotidyltransferase poly(A) polymerase cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_336035_2 944481.JAFP01000001_gene707 2.02e-16 73.2 COG3118@1|root,COG3118@2|Bacteria,1NXN2@1224|Proteobacteria,430GJ@68525|delta/epsilon subdivisions,2WVXE@28221|Deltaproteobacteria,2M79Y@213113|Desulfurellales 28221|Deltaproteobacteria O Thioredoxin - - - - - - - - - - - - Thioredoxin k59_172150_1 999419.HMPREF1077_00256 2.7e-30 115.0 COG1082@1|root,COG1082@2|Bacteria,4NGBE@976|Bacteroidetes,2FNN2@200643|Bacteroidia,22ZAK@171551|Porphyromonadaceae 976|Bacteroidetes G AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N k59_172150_2 1168034.FH5T_08025 3.37e-181 513.0 COG0673@1|root,COG0673@2|Bacteria,4NGGS@976|Bacteroidetes,2FTQH@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_499193_1 572477.Alvin_1352 2.24e-38 134.0 COG1390@1|root,COG1390@2|Bacteria,1R8BT@1224|Proteobacteria,1S1WN@1236|Gammaproteobacteria,1WXX4@135613|Chromatiales 135613|Chromatiales C V-type proton ATPase subunit E - - - ko:K02121 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_E k59_499193_2 713587.THITH_17470 1.28e-15 73.2 COG1436@1|root,COG1436@2|Bacteria,1MZUE@1224|Proteobacteria,1SATX@1236|Gammaproteobacteria,1WYZV@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane - - - - - - - - - - - - ATP-synt_F k59_432567_1 1454004.AW11_03580 8.58e-69 224.0 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria 28216|Betaproteobacteria S Phospholipase, patatin family - - - ko:K07001 - - - - ko00000 - - - Patatin k59_629745_1 1249627.D779_1402 1.32e-83 275.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1WW9S@135613|Chromatiales 135613|Chromatiales E Bacterial transglutaminase-like N-terminal - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_791428_1 1123503.KB908058_gene955 1.66e-39 142.0 COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,2KH9F@204458|Caulobacterales 204458|Caulobacterales O PFAM OsmC family protein - - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4,OsmC k59_791428_2 270374.MELB17_23420 1.32e-29 118.0 COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,466VR@72275|Alteromonadaceae 1236|Gammaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_694822_1 396588.Tgr7_0584 7.96e-125 368.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1WWN2@135613|Chromatiales 135613|Chromatiales O PFAM peptidase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_596731_1 1168034.FH5T_11070 2.2e-70 217.0 COG1595@1|root,COG1595@2|Bacteria,4NETF@976|Bacteroidetes,2FNPY@200643|Bacteroidia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily sigG - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_172166_1 234267.Acid_6122 2.23e-50 172.0 2DB88@1|root,2Z7QT@2|Bacteria,3Y61J@57723|Acidobacteria 57723|Acidobacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_336053_1 1165841.SULAR_00505 2.95e-75 240.0 COG0348@1|root,COG0348@2|Bacteria,1N605@1224|Proteobacteria,42XAR@68525|delta/epsilon subdivisions,2YR2P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 k59_400220_1 1187851.A33M_2286 0.000383 47.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,3FCMN@34008|Rhodovulum 28211|Alphaproteobacteria I Methylmalonyl-CoA mutase bhbA - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_139864_1 572544.Ilyop_1381 9.64e-123 353.0 COG0496@1|root,COG0496@2|Bacteria,37BZU@32066|Fusobacteria 32066|Fusobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_532002_1 1122986.KB908323_gene889 6.92e-06 50.1 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_532002_2 700598.Niako_6193 3.76e-20 94.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,4PKV1@976|Bacteroidetes,1IQ5A@117747|Sphingobacteriia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HNOBA,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg k59_432583_1 1049564.TevJSym_ac00170 7.4e-50 173.0 COG1165@1|root,COG1165@2|Bacteria,1MVMZ@1224|Proteobacteria,1RNRS@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD GO:0003674,GO:0003824,GO:0005488,GO:0006732,GO:0008150,GO:0008152,GO:0008683,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016833,GO:0019842,GO:0030976,GO:0036094,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070204,GO:0071704,GO:0097159,GO:1901363,GO:1901576,GO:1901661,GO:1901663,GO:1901681 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_2301 TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_989123_2 572544.Ilyop_1363 1.23e-79 249.0 COG2035@1|root,COG2035@2|Bacteria,37A41@32066|Fusobacteria 32066|Fusobacteria S Domain of unknown function (DUF368) - - - ko:K08974 - - - - ko00000 - - - DUF368 k59_989123_3 1319815.HMPREF0202_02330 2.5e-66 205.0 COG1327@1|root,COG1327@2|Bacteria,379YX@32066|Fusobacteria 32066|Fusobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_989123_4 1095747.HMPREF1049_1145 1.86e-61 193.0 COG1762@1|root,COG1762@2|Bacteria,379WR@32066|Fusobacteria 32066|Fusobacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 - - 2.7.1.202 ko:K02768,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2 k59_989123_5 1408439.JHXW01000015_gene1713 1.32e-49 169.0 COG1381@1|root,COG1381@2|Bacteria,379B9@32066|Fusobacteria 32066|Fusobacteria L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_139872_1 504487.JCM19302_415 4.04e-83 266.0 COG1629@1|root,COG4771@2|Bacteria,4NFKZ@976|Bacteroidetes,1HY23@117743|Flavobacteriia 976|Bacteroidetes P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_596748_1 471854.Dfer_0312 7.83e-26 110.0 COG3250@1|root,COG3250@2|Bacteria,4NEDP@976|Bacteroidetes,47JV2@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - Glyco_hydro_2_N,SASA k59_596748_2 925409.KI911562_gene1205 1.27e-29 108.0 COG1846@1|root,COG1846@2|Bacteria,4PKFS@976|Bacteroidetes,1IZ1N@117747|Sphingobacteriia 976|Bacteroidetes K Winged helix DNA-binding domain marR - - - - - - - - - - - HTH_34 k59_825512_1 1123518.ARWI01000001_gene94 1.1e-24 108.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,MASE1,MASE3,PAS,PAS_4,PAS_9,Phosphonate-bd,dCache_1 k59_955734_1 448385.sce6263 1.8e-27 116.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales 28221|Deltaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - - k59_368299_1 1165841.SULAR_00190 2.4e-97 293.0 COG1565@1|root,COG1565@2|Bacteria,1QNDB@1224|Proteobacteria,42MQ8@68525|delta/epsilon subdivisions,2YNBU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_368299_2 1165841.SULAR_00180 2.02e-14 72.4 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2YMRT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_237164_1 869213.JCM21142_104438 1.68e-87 264.0 COG1028@1|root,COG1028@2|Bacteria,4NFDX@976|Bacteroidetes,47JV9@768503|Cytophagia 976|Bacteroidetes IQ with different specificities (related to short-chain alcohol idnO - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 k59_662728_1 1168034.FH5T_01815 4.75e-101 299.0 COG3717@1|root,COG3717@2|Bacteria,4NDUV@976|Bacteroidetes,2FMP5@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_269015_1 1442599.JAAN01000032_gene1550 9.94e-10 57.4 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1X3RF@135614|Xanthomonadales 135614|Xanthomonadales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_269015_2 1049564.TevJSym_aa00130 2.06e-48 156.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1J6C1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_989146_1 519989.ECTPHS_00894 1.52e-38 138.0 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1WY2X@135613|Chromatiales 135613|Chromatiales S Protein of unknown function, DUF484 - - - ko:K09921 - - - - ko00000 - - - DUF484 k59_989146_2 1232683.ADIMK_0902 1.8e-05 45.8 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,464H0@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_139885_1 439235.Dalk_2981 4.03e-36 135.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42Q2C@68525|delta/epsilon subdivisions,2WKNN@28221|Deltaproteobacteria,2MN1W@213118|Desulfobacterales 28221|Deltaproteobacteria C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_139885_2 439235.Dalk_2980 7.88e-50 164.0 COG1014@1|root,COG1014@2|Bacteria,1RJBM@1224|Proteobacteria,42T3A@68525|delta/epsilon subdivisions,2WPV1@28221|Deltaproteobacteria,2MNCY@213118|Desulfobacterales 28221|Deltaproteobacteria C indolepyruvate ferredoxin oxidoreductase, beta subunit - - 1.2.7.8 ko:K00180 - - - - br01601,ko00000,ko01000 - - - POR k59_336083_1 1123393.KB891327_gene305 2.78e-55 175.0 COG5485@1|root,COG5485@2|Bacteria,1RBA1@1224|Proteobacteria 1224|Proteobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_336083_2 62928.azo2621 8.02e-51 165.0 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2VSHT@28216|Betaproteobacteria,2KWE3@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial protein of unknown function (DUF924) - - - - - - - - - - - - DUF924 k59_336085_1 1328313.DS2_00015 5.7e-87 276.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,1RSM7@1236|Gammaproteobacteria,4661S@72275|Alteromonadaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_955745_1 1288963.ADIS_4778 2.36e-25 110.0 COG3209@1|root,COG3291@1|root,COG4733@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,4NTHZ@976|Bacteroidetes 976|Bacteroidetes M 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - - k59_499245_1 1415755.JQLV01000002_gene234 5.35e-49 160.0 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,1SABV@1236|Gammaproteobacteria,1XM0E@135619|Oceanospirillales 135619|Oceanospirillales L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_532036_1 498761.HM1_2880 7.8e-56 189.0 COG4653@1|root,COG4653@2|Bacteria,1TS6A@1239|Firmicutes,24994@186801|Clostridia 186801|Clostridia S phage major capsid protein, HK97 family - - - - - - - - - - - - Phage_capsid k59_336086_1 983917.RGE_27120 1.06e-20 93.6 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,1KKDN@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_989152_2 2325.TKV_c06760 9.79e-76 239.0 COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,42F1C@68295|Thermoanaerobacterales 186801|Clostridia M PFAM NAD-dependent epimerase dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_107107_1 29581.BW37_02218 6.21e-49 176.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,472YU@75682|Oxalobacteraceae 28216|Betaproteobacteria I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_139894_1 1489678.RDMS_03930 1.73e-23 103.0 COG0147@1|root,COG0147@2|Bacteria,1WI8S@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_301817_2 1540257.JQMW01000011_gene2012 2.31e-79 241.0 COG0127@1|root,COG0127@2|Bacteria,1UBM7@1239|Firmicutes,24CWC@186801|Clostridia,36FSM@31979|Clostridiaceae 186801|Clostridia F Ham1 family - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_727137_2 387093.SUN_0252 9.26e-21 89.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,42ME8@68525|delta/epsilon subdivisions,2YN4W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_890431_1 96561.Dole_0036 3.16e-14 76.3 COG3018@1|root,COG3018@2|Bacteria,1R9S8@1224|Proteobacteria,42RI7@68525|delta/epsilon subdivisions,2WP0N@28221|Deltaproteobacteria,2MIVN@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - LPP20 k59_955752_1 519989.ECTPHS_08443 5.41e-59 204.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_564493_1 765912.Thimo_2826 1.64e-22 88.2 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1WZBU@135613|Chromatiales 135613|Chromatiales J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_564493_2 661367.LLO_0340 7.53e-55 174.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1JEHD@118969|Legionellales 118969|Legionellales J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_139897_1 767434.Fraau_1089 6.22e-132 390.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1X3B2@135614|Xanthomonadales 135614|Xanthomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1021668_1 1265505.ATUG01000002_gene1832 4.37e-61 197.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42NHU@68525|delta/epsilon subdivisions,2WIZ1@28221|Deltaproteobacteria,2MIQ6@213118|Desulfobacterales 28221|Deltaproteobacteria I acyl-CoA dehydrogenase - - 1.3.99.32 ko:K16173 ko00362,ko01120,map00362,map01120 - R05579 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1022112_2 1094184.KWO_0103135 1.64e-56 179.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,1X6EI@135614|Xanthomonadales 135614|Xanthomonadales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_466827_1 1319815.HMPREF0202_01457 5.81e-32 126.0 COG4772@1|root,COG4772@2|Bacteria,378UD@32066|Fusobacteria 32066|Fusobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_695111_1 1123326.JFBL01000005_gene1102 3.84e-199 558.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2YNA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C alanine dehydrogenase ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_956195_1 879212.DespoDRAFT_02543 3.8e-51 169.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42PYM@68525|delta/epsilon subdivisions,2WJ37@28221|Deltaproteobacteria,2MIP8@213118|Desulfobacterales 28221|Deltaproteobacteria C Electron transfer flavoprotein - - - ko:K03521 - - - - ko00000 - - - ETF k59_956195_2 1121396.KB893101_gene476 4.03e-13 68.9 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2WK12@28221|Deltaproteobacteria,2MIA2@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Electron transfer flavoprotein alpha - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_532557_1 1537917.JU82_05655 4.66e-98 291.0 COG0433@1|root,COG0433@2|Bacteria,1Q4H7@1224|Proteobacteria,42Z6M@68525|delta/epsilon subdivisions,2YR7W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0433 Predicted ATPase - - - - - - - - - - - - - k59_40282_1 1453505.JASY01000005_gene1419 7.14e-47 164.0 COG0141@1|root,COG0141@2|Bacteria,4NFPZ@976|Bacteroidetes,1HZ69@117743|Flavobacteriia,2NSJG@237|Flavobacterium 976|Bacteroidetes E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_432978_1 1122179.KB890447_gene241 4.14e-27 102.0 COG0662@1|root,COG0662@2|Bacteria 2|Bacteria G Cupin 2, conserved barrel domain protein - - - ko:K14673 - - - - ko00000,ko01008 - - - Cupin_2 k59_432978_2 439235.Dalk_0147 4.17e-69 222.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2MKKR@213118|Desulfobacterales 28221|Deltaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Hydrolase_4 k59_432978_3 765912.Thimo_0296 8.88e-77 232.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales 135613|Chromatiales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_432978_4 1049564.TevJSym_ap00720 0.0 1798.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1J5E8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_432978_5 396588.Tgr7_0976 6.16e-10 57.4 COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,1S6E7@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_432978_6 1049564.TevJSym_ap00730 3.35e-226 629.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1J4TG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the CarA family carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040 CPSase_sm_chain,GATase k59_432978_7 1123355.JHYO01000004_gene2561 2.2e-77 236.0 COG0703@1|root,COG0703@2|Bacteria 2|Bacteria F shikimate kinase activity aroK - 2.7.1.71,4.2.3.4 ko:K00891,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_432978_8 1049564.TevJSym_bc00280 0.0 1019.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1J4UC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Domain of unknown function (DUF1974) fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_432978_9 396588.Tgr7_1566 2.34e-56 184.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S66F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_432978_10 717774.Marme_0503 2.16e-66 206.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1XJWN@135619|Oceanospirillales 135619|Oceanospirillales I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_307182_1 411901.BACCAC_02303 2.19e-27 106.0 COG1051@1|root,COG1051@2|Bacteria,4NE29@976|Bacteroidetes,2G31G@200643|Bacteroidia,4AMFI@815|Bacteroidaceae 976|Bacteroidetes F Hydrolase, NUDIX family - - - - - - - - - - - - NUDIX k59_44749_1 2340.JV46_08270 5e-65 211.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1J4T3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Mg2 and Co2 transporter CorB yfjD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_700224_1 572544.Ilyop_0176 3.86e-61 193.0 COG0081@1|root,COG0081@2|Bacteria,3783W@32066|Fusobacteria 32066|Fusobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_700224_2 572544.Ilyop_0177 8.24e-84 251.0 COG0244@1|root,COG0244@2|Bacteria,378JA@32066|Fusobacteria 32066|Fusobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_700224_3 1278306.KB906918_gene1246 2.6e-56 177.0 COG0222@1|root,COG0222@2|Bacteria,37AD0@32066|Fusobacteria 32066|Fusobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_700224_4 572544.Ilyop_0179 0.0 1956.0 COG0085@1|root,COG0085@2|Bacteria,3785D@32066|Fusobacteria 32066|Fusobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_700224_5 469617.FUAG_02275 7.72e-154 469.0 COG0086@1|root,COG0086@2|Bacteria,378G7@32066|Fusobacteria 32066|Fusobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_795042_1 387093.SUN_1906 4.51e-102 318.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2YMNT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1026480_1 261292.Nit79A3_1075 2.71e-19 87.8 COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_242436_1 86416.Clopa_4711 9.34e-175 499.0 COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia,36DFN@31979|Clostridiaceae 186801|Clostridia G glucuronate isomerase uxaC - 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - - UxaC k59_178260_1 929558.SMGD1_2396 2.75e-92 282.0 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,42MB5@68525|delta/epsilon subdivisions,2YMRI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E phospho-2-dehydro-3-deoxyheptonate aldolase aroG - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0134 DAHP_synth_2 k59_112020_1 1242864.D187_010454 1.51e-64 213.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2YYTV@29|Myxococcales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_437940_1 1122614.JHZF01000013_gene3336 2e-10 64.7 COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,2PCEW@252301|Oceanicola 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain gst - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_C_3,GST_N_3 k59_437940_2 1122970.AUHC01000019_gene2094 1.36e-07 50.1 COG5470@1|root,COG5470@2|Bacteria,1PJI1@1224|Proteobacteria,2VAQF@28211|Alphaproteobacteria,2KB8A@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF1330) - - - - - - - - - - - - DUF1330 k59_210726_1 396588.Tgr7_2903 2.93e-08 52.4 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria,1WYZY@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_210726_2 187272.Mlg_0355 4.96e-55 176.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_342067_1 1537917.JU82_11805 2.21e-57 185.0 COG0115@1|root,COG0115@2|Bacteria,1N3ZD@1224|Proteobacteria,42TNN@68525|delta/epsilon subdivisions,2YPU5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH Branched-chain amino acid aminotransferase - - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k59_8831_1 572480.Arnit_0211 2.33e-139 403.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,42PX0@68525|delta/epsilon subdivisions 1224|Proteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis gpgS - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_307202_2 62928.azo2871 1.72e-65 204.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VQTQ@28216|Betaproteobacteria,2KW1F@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_178271_1 1168034.FH5T_13995 5.57e-83 266.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,4NGJ4@976|Bacteroidetes,2FN4R@200643|Bacteroidia 976|Bacteroidetes G trehalose-phosphatase otsB - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase k59_929834_1 391598.FBBAL38_01755 3.03e-70 218.0 COG0664@1|root,COG0664@2|Bacteria,4NNT7@976|Bacteroidetes,1I1XI@117743|Flavobacteriia 976|Bacteroidetes K CRP FNR family transcriptional regulator - - - ko:K01420 - - - - ko00000,ko03000 - - - Crp,HTH_Crp_2,cNMP_binding k59_929834_2 313596.RB2501_09420 7.33e-19 79.0 2DI4K@1|root,3020V@2|Bacteria,4NV1J@976|Bacteroidetes,1I507@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_929834_3 153721.MYP_3170 6.8e-08 57.0 COG3794@1|root,COG3794@2|Bacteria,4NXN9@976|Bacteroidetes 976|Bacteroidetes C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind k59_961719_1 443143.GM18_2244 8.1e-44 157.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_961719_2 747365.Thena_0855 9.05e-51 176.0 COG4424@1|root,COG4424@2|Bacteria,1V5ZE@1239|Firmicutes,25053@186801|Clostridia 186801|Clostridia S PFAM Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_505622_1 1502850.FG91_00593 0.000255 50.4 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2K0YG@204457|Sphingomonadales 204457|Sphingomonadales Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind k59_44769_1 525904.Tter_0374 4.18e-147 428.0 COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria 2|Bacteria S Belongs to the RtcB family rtcB GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_700252_1 1172190.M947_03970 5.44e-131 389.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H ATP citrate synthase - - 2.3.3.8 ko:K15230 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,Ligase_CoA k59_765406_1 1232437.KL661963_gene3380 5e-66 213.0 COG1148@1|root,COG1148@2|Bacteria,1N26U@1224|Proteobacteria,43BRX@68525|delta/epsilon subdivisions,2WKFG@28221|Deltaproteobacteria,2MJAN@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 k59_44772_1 1121887.AUDK01000017_gene66 1.05e-108 332.0 COG0702@1|root,COG0702@2|Bacteria,4NG5U@976|Bacteroidetes,1I0T9@117743|Flavobacteriia,2NSG8@237|Flavobacterium 976|Bacteroidetes GM PFAM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_732635_1 1168034.FH5T_08155 6.07e-80 249.0 COG0589@1|root,COG0589@2|Bacteria,4NHBB@976|Bacteroidetes,2FPV4@200643|Bacteroidia 976|Bacteroidetes T universal stress protein uspA - - - - - - - - - - - DUF2007,Usp k59_243138_1 556267.HWAG_00659 7.35e-78 241.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2YN11@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_179048_2 1173024.KI912149_gene5995 5.35e-98 302.0 COG2805@1|root,COG2805@2|Bacteria,1G0HI@1117|Cyanobacteria,1JJJN@1189|Stigonemataceae 1117|Cyanobacteria NU Type II/IV secretion system protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_795559_1 326298.Suden_0430 7.21e-111 335.0 COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,42YRS@68525|delta/epsilon subdivisions,2YRD3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF808) - - - ko:K09781 - - - - ko00000 - - - DUF808 k59_79801_3 1089121.G8I4P7_9CAUD 5.23e-10 56.2 4QHNZ@10239|Viruses,4QYHF@35237|dsDNA viruses no RNA stage,4QRCH@28883|Caudovirales,4QM3K@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_732638_1 439235.Dalk_1330 4.86e-51 174.0 COG3464@1|root,COG3464@2|Bacteria,1PFY7@1224|Proteobacteria,4377W@68525|delta/epsilon subdivisions,2X29U@28221|Deltaproteobacteria,2MP93@213118|Desulfobacterales 28221|Deltaproteobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3 k59_795562_1 1123399.AQVE01000031_gene206 2.52e-54 194.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,45ZNT@72273|Thiotrichales 72273|Thiotrichales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_406539_1 1278306.KB906918_gene1248 6.81e-55 177.0 COG0081@1|root,COG0081@2|Bacteria,3783W@32066|Fusobacteria 32066|Fusobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_406539_2 1319815.HMPREF0202_01989 4.29e-85 252.0 COG0080@1|root,COG0080@2|Bacteria,379YU@32066|Fusobacteria 32066|Fusobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_406539_3 572544.Ilyop_0174 7.64e-95 281.0 COG0250@1|root,COG0250@2|Bacteria,379ET@32066|Fusobacteria 32066|Fusobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_701032_1 886293.Sinac_7468 1.64e-52 186.0 COG0515@1|root,COG0515@2|Bacteria,2IXG3@203682|Planctomycetes 203682|Planctomycetes KLT Serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_146569_1 1140.Synpcc7942_0781 4.63e-89 287.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1G0GP@1117|Cyanobacteria,1GYTG@1129|Synechococcus 1117|Cyanobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_930591_1 511062.GU3_06610 1.42e-13 73.6 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1Y4GC@135624|Aeromonadales 135624|Aeromonadales S Tetratricopeptide repeat-like domain - - - - - - - - - - - - TPR_21 k59_930591_2 1283300.ATXB01000001_gene1612 3.68e-15 77.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1XE8E@135618|Methylococcales 135618|Methylococcales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_146570_1 572544.Ilyop_0691 1.84e-86 257.0 COG1905@1|root,COG1905@2|Bacteria,37A55@32066|Fusobacteria 2|Bacteria C PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit nuoE - 1.12.1.3,1.6.5.3 ko:K00334,ko:K18330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_146570_2 572544.Ilyop_0690 5.76e-43 155.0 COG1894@1|root,COG1894@2|Bacteria,378S3@32066|Fusobacteria 32066|Fusobacteria C PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit hymB - 1.12.1.3 ko:K18331 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_374297_1 572544.Ilyop_0873 2.5e-55 186.0 COG0845@1|root,COG0845@2|Bacteria,379D4@32066|Fusobacteria 32066|Fusobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_308026_1 765912.Thimo_2345 1.36e-60 196.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1WXMF@135613|Chromatiales 135613|Chromatiales O PFAM Thioredoxin - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_570484_1 207559.Dde_1891 6.02e-112 335.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42SS8@68525|delta/epsilon subdivisions,2WPMH@28221|Deltaproteobacteria,2MAUU@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Metallophosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_9418_1 177437.HRM2_25900 7.67e-72 239.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42NQG@68525|delta/epsilon subdivisions,2WJXC@28221|Deltaproteobacteria,2MJBJ@213118|Desulfobacterales 28221|Deltaproteobacteria L TIGRFAM DNA topoisomerase III, bacteria and conjugative plasmid topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - DEAD,HRDC,Helicase_C,RecQ_Zn_bind,Topoisom_bac,Toprim,Toprim_Crpt,zf-C4_Topoisom k59_732655_1 335543.Sfum_3750 1.41e-53 188.0 COG0673@1|root,COG3494@1|root,COG0673@2|Bacteria,COG3494@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,2MR8J@213462|Syntrophobacterales 28221|Deltaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold gnnA - - ko:K09949 - - - - ko00000 - - iAF987.Gmet_2352 GFO_IDH_MocA,GFO_IDH_MocA_C k59_471694_1 1410612.JNKO01000007_gene2016 1.04e-08 59.7 COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,24ADG@186801|Clostridia,2PRZ4@265975|Oribacterium 186801|Clostridia S Putative glycosyl hydrolase domain - - - - - - - - - - - - DUF4015 k59_506502_1 563040.Saut_1149 1.73e-71 219.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2YN3P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Imidazoleglycerol-phosphate dehydratase hisB - 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD,PNK3P k59_506502_2 709032.Sulku_1432 7.94e-16 75.1 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2YMTU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_863860_1 1122947.FR7_2367 9.89e-14 72.0 COG1418@1|root,COG1418@2|Bacteria,1UIP0@1239|Firmicutes,4H9CH@909932|Negativicutes 909932|Negativicutes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_342895_1 1165841.SULAR_03327 2.59e-31 121.0 COG1721@1|root,COG1721@2|Bacteria 2|Bacteria E protein (some members contain a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - DUF58 k59_438739_1 765911.Thivi_1765 4.92e-17 79.7 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_438739_2 314278.NB231_05531 1.54e-22 96.3 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1WWH6@135613|Chromatiales 135613|Chromatiales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_538629_1 1370121.AUWS01000033_gene4155 5.42e-62 214.0 COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,233CA@1762|Mycobacteriaceae 201174|Actinobacteria P thought to play an important role in the mineralization of sulfates catalytic activity a phenol sulfate H2O a phenol sulfate atsB GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - DUF1269,Sulfatase k59_863863_1 981384.AEYW01000018_gene3284 1.1e-13 70.9 COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,2TTSD@28211|Alphaproteobacteria,4NCZM@97050|Ruegeria 28211|Alphaproteobacteria L RNase_H superfamily - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,RNase_H_2 k59_471703_1 522373.Smlt0906 1.67e-70 219.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1X36G@135614|Xanthomonadales 135614|Xanthomonadales J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_342898_1 879212.DespoDRAFT_00863 3.25e-34 117.0 2C06Z@1|root,3335S@2|Bacteria,1NI0C@1224|Proteobacteria,42X3F@68525|delta/epsilon subdivisions,2WT33@28221|Deltaproteobacteria,2MP40@213118|Desulfobacterales 28221|Deltaproteobacteria S Nif11 domain - - - - - - - - - - - - Nif11 k59_795598_1 876044.IMCC3088_2535 1.76e-49 175.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3IM@1236|Gammaproteobacteria,1J9GH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_732671_1 1196028.ALEF01000017_gene2486 9.36e-16 77.0 COG0591@1|root,COG0591@2|Bacteria,1UZ0Z@1239|Firmicutes,4HCWG@91061|Bacilli,4C4I6@84406|Virgibacillus 91061|Bacilli E Sodium:solute symporter family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_732671_2 1168034.FH5T_19560 2.41e-88 268.0 COG1284@1|root,COG1284@2|Bacteria,4NG9F@976|Bacteroidetes,2FS6Q@200643|Bacteroidia 976|Bacteroidetes S protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179,YitT_membrane k59_243179_1 1410608.JNKX01000020_gene73 1.79e-26 112.0 2CF1V@1|root,2Z9BC@2|Bacteria,4NHGM@976|Bacteroidetes,2FNUI@200643|Bacteroidia,4AN3Z@815|Bacteroidaceae 976|Bacteroidetes S Protein of unknown function (DUF4876) - - - - - - - - - - - - DUF4876 k59_308049_1 1121405.dsmv_1018 2.92e-57 195.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2MHX2@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_863873_1 273121.WS0543 1.12e-07 53.9 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_863873_2 565045.NOR51B_2657 3.81e-12 69.3 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1J8NV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG1459 Type II secretory pathway, component PulF xpsF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_45470_1 472759.Nhal_1755 2.61e-93 289.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1WWK2@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_374324_1 1537917.JU82_05210 5.27e-145 411.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2YN5T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the SAICAR synthetase family purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_342900_1 1230341.MJ3_01817 1.01e-06 57.4 COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,4HB35@91061|Bacilli 91061|Bacilli L Transposase IS116 IS110 IS902 - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_438751_1 2340.JV46_19290 0.0 947.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_962517_2 1168034.FH5T_22020 3.61e-22 95.5 COG2972@1|root,COG2972@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - 2TM,His_kinase k59_636320_1 582402.Hbal_2617 9.33e-165 487.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,2U0EP@28211|Alphaproteobacteria,43W6Q@69657|Hyphomonadaceae 28211|Alphaproteobacteria P TIGRFAM TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_506536_3 525898.Sdel_0190 2.42e-09 56.6 COG0009@1|root,COG0009@2|Bacteria,1Q1KW@1224|Proteobacteria,42TY2@68525|delta/epsilon subdivisions,2YPSU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J L-threonylcarbamoyladenylate synthase tsaC - - - - - - - - - - - - k59_374331_1 926562.Oweho_2151 4.93e-07 52.8 COG0272@1|root,COG0758@1|root,COG0272@2|Bacteria,COG0758@2|Bacteria,4NF7T@976|Bacteroidetes,1HXG0@117743|Flavobacteriia,2PAKJ@246874|Cryomorphaceae 976|Bacteroidetes L DNA recombination-mediator protein A dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A,HHH_5 k59_538660_1 1123377.AUIV01000026_gene572 3.1e-17 80.1 COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S2VT@1236|Gammaproteobacteria,1XCIY@135614|Xanthomonadales 135614|Xanthomonadales M COG0810 Periplasmic protein TonB, links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_538660_2 1500890.JQNL01000001_gene1935 8.94e-14 71.2 COG0811@1|root,COG0811@2|Bacteria,1RDJF@1224|Proteobacteria,1T1A5@1236|Gammaproteobacteria,1XD3P@135614|Xanthomonadales 135614|Xanthomonadales U Biopolymer transporter ExbB - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_701086_1 879212.DespoDRAFT_03549 6.42e-44 148.0 COG1983@1|root,COG1983@2|Bacteria,1PWDN@1224|Proteobacteria,42TA8@68525|delta/epsilon subdivisions,2WPVU@28221|Deltaproteobacteria,2MKDS@213118|Desulfobacterales 28221|Deltaproteobacteria KT PspC domain pspC - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC k59_215211_1 572544.Ilyop_1339 1.44e-82 260.0 COG1283@1|root,COG1283@2|Bacteria,378CQ@32066|Fusobacteria 32066|Fusobacteria P Na Pi-cotransporter II-like protein - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_377816_1 395493.BegalDRAFT_0441 7.09e-30 119.0 COG0845@1|root,COG0845@2|Bacteria,1MWZ9@1224|Proteobacteria,1RM91@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_D23 k59_769912_1 768671.ThimaDRAFT_0124 2.05e-40 147.0 COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,1RMZV@1236|Gammaproteobacteria,1X2SU@135613|Chromatiales 135613|Chromatiales O OsmC-like protein - - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4,OsmC k59_966148_1 1038869.AXAN01000057_gene6014 9.95e-53 189.0 COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,1JZSA@119060|Burkholderiaceae 28216|Betaproteobacteria T catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg k59_510050_1 67356.KL575649_gene7528 6.11e-41 147.0 COG3533@1|root,COG3533@2|Bacteria,2GM60@201174|Actinobacteria 201174|Actinobacteria G protein conserved in bacteria - - - ko:K09955 - - - - ko00000 - - - DUF1793,DUF4964,DUF4965,DUF5127,Glyco_hydro_127,Laminin_G_3,RicinB_lectin_2 k59_799295_1 1121937.AUHJ01000010_gene1753 3.75e-32 129.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,464AD@72275|Alteromonadaceae 1236|Gammaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_736192_1 273121.WS1759 2.07e-05 47.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,42MPN@68525|delta/epsilon subdivisions,2YMHV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar basal body protein flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_13684_1 745310.G432_03260 3.45e-33 127.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria,2K1FH@204457|Sphingomonadales 204457|Sphingomonadales U alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_378517_1 1236541.BALL01000041_gene3868 1.62e-22 92.4 COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria,2QAUH@267890|Shewanellaceae 1236|Gammaproteobacteria K Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C k59_278742_1 1415780.JPOG01000001_gene27 5.42e-219 615.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1X3KV@135614|Xanthomonadales 135614|Xanthomonadales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_278742_2 519989.ECTPHS_06512 1.42e-13 69.3 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,1X2NE@135613|Chromatiales 135613|Chromatiales S mRNA catabolic process - - - - - - - - - - - - - k59_117158_1 555779.Dthio_PD0329 1.53e-89 274.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2M88A@213115|Desulfovibrionales 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_640535_1 1168034.FH5T_03540 5.13e-116 340.0 COG0223@1|root,COG0223@2|Bacteria,4NE8U@976|Bacteroidetes,2FN5I@200643|Bacteroidia 976|Bacteroidetes J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_607935_1 1247649.D560_0881 1.36e-18 80.1 COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,2VTX1@28216|Betaproteobacteria,3T4KU@506|Alcaligenaceae 28216|Betaproteobacteria D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE k59_607935_2 1158756.AQXQ01000012_gene1313 2.61e-26 103.0 COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,1RNJ0@1236|Gammaproteobacteria,1WWCA@135613|Chromatiales 135613|Chromatiales D Belongs to the ParA family - - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_673668_1 314345.SPV1_11011 1.32e-49 169.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria 1224|Proteobacteria P COG0530 Ca2 Na antiporter yrbG GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0008150,GO:0008273,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015085,GO:0015267,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022803,GO:0022804,GO:0022821,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030955,GO:0031224,GO:0031226,GO:0031402,GO:0031420,GO:0034220,GO:0035725,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070588,GO:0070838,GO:0071804,GO:0071805,GO:0071944,GO:0072503,GO:0072507,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516 - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - iAPECO1_1312.APECO1_3239,iECABU_c1320.ECABU_c36110,iECNA114_1301.ECNA114_3275,iECOK1_1307.ECOK1_3617,iECS88_1305.ECS88_3578,iECSF_1327.ECSF_3028,iUMN146_1321.UM146_00400,iUTI89_1310.UTI89_C3632,ic_1306.c3956 Na_Ca_ex k59_640539_1 187272.Mlg_2195 2.44e-73 235.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_673675_1 768670.Calni_1141 7.29e-70 224.0 COG1373@1|root,COG1373@2|Bacteria,2GG7K@200930|Deferribacteres 200930|Deferribacteres S AAA domain - - - ko:K07133 - - - - ko00000 - - - AAA_14 k59_247596_1 713587.THITH_06650 1.55e-25 110.0 COG2202@1|root,COG3221@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3221@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_3,PAS_9,Phosphonate-bd,Response_reg k59_13704_1 1168034.FH5T_10880 6.98e-70 228.0 COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,2FMMH@200643|Bacteroidia 976|Bacteroidetes H acetolactate synthase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_312221_1 713587.THITH_06805 1.26e-94 301.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1WX2T@135613|Chromatiales 135613|Chromatiales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_770659_1 977880.RALTA_A1692 1.52e-32 120.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,1K0W5@119060|Burkholderiaceae 28216|Betaproteobacteria E Methionine aminopeptidase map GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_49663_1 882.DVU_1298 4.93e-71 215.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,42RDQ@68525|delta/epsilon subdivisions,2WND8@28221|Deltaproteobacteria,2MBJ6@213115|Desulfovibrionales 28221|Deltaproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_476073_1 926569.ANT_04100 1.14e-34 133.0 COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi 200795|Chloroflexi K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_117195_1 425400.LS65_05595 3.93e-32 120.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,42M0Q@68525|delta/epsilon subdivisions,2YMXU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_117195_2 990073.ATHU01000001_gene1706 4.41e-15 76.6 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42MS0@68525|delta/epsilon subdivisions,2YMTX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,dCache_3 k59_347219_1 1249627.D779_4191 3.77e-80 249.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RQ04@1236|Gammaproteobacteria,1WXUZ@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_770664_1 1385517.N800_06035 6.75e-55 190.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales 135614|Xanthomonadales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_13722_1 768671.ThimaDRAFT_4443 9.16e-45 166.0 COG0457@1|root,COG0457@2|Bacteria,1R3SH@1224|Proteobacteria,1S6CN@1236|Gammaproteobacteria,1WYE5@135613|Chromatiales 135613|Chromatiales O Tetratricopeptide repeat - - - - - - - - - - - - TPR_12,TPR_7 k59_278779_1 387631.Asulf_01109 8.34e-15 74.7 COG1055@1|root,arCOG00238@2157|Archaea,2XTRK@28890|Euryarchaeota,245XT@183980|Archaeoglobi 183980|Archaeoglobi P Sodium:sulfate symporter transmembrane region - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_1000011_1 1049564.TevJSym_ab01780 1.03e-200 588.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMFB@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_1000011_2 768671.ThimaDRAFT_0914 1.58e-98 294.0 COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria,1S0NK@1236|Gammaproteobacteria,1WWZZ@135613|Chromatiales 1236|Gammaproteobacteria C PFAM Cytochrome C - - - - - - - - - - - - Cytochrom_C k59_1000011_3 765914.ThisiDRAFT_2784 2.37e-129 380.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1WW21@135613|Chromatiales 135613|Chromatiales M UTP-glucose-1-phosphate uridylyltransferase - - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1000011_4 697282.Mettu_0417 6.44e-189 543.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1XDQU@135618|Methylococcales 135618|Methylococcales G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_1000011_5 1049564.TevJSym_ac01020 1.85e-270 756.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_1000011_6 1049564.TevJSym_ac01030 3.01e-252 698.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1J9BP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_1000011_7 1049564.TevJSym_ac01040 0.0 1084.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1J8KX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941 Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1000011_8 1049564.TevJSym_ac01050 3.18e-292 811.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1J4P5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the GPI family pgi GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcSMS35_1347.EcSMS35_4486 PGI k59_1000011_9 1249627.D779_1588 2.21e-193 556.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1WWCY@135613|Chromatiales 135613|Chromatiales G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_1000011_10 519989.ECTPHS_00335 7.69e-65 199.0 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1WY82@135613|Chromatiales 135613|Chromatiales H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_1000011_11 765912.Thimo_3513 1.49e-113 336.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_1000011_12 2340.JV46_18470 2.3e-110 326.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1J4P1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00132,iE2348C_1286.E2348C_0137,iECBD_1354.ECBD_3485,iECB_1328.ECB_00133,iECD_1391.ECD_00133,iPC815.YPO3401 Pantoate_transf k59_1000011_13 1121937.AUHJ01000012_gene2769 6.27e-80 245.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,464II@72275|Alteromonadaceae 1236|Gammaproteobacteria F Deoxynucleoside kinase dgk - - - - - - - - - - - dNK k59_1000011_14 1255043.TVNIR_2815 6.1e-54 176.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1WYQM@135613|Chromatiales 135613|Chromatiales H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_1000011_15 1249627.D779_1592 1.28e-177 508.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_868276_1 765910.MARPU_04975 7.48e-58 192.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1WY1X@135613|Chromatiales 135613|Chromatiales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_705458_1 1537917.JU82_08270 1.2e-152 443.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2YMUF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_84155_1 525257.HMPREF0204_10150 1.93e-16 80.9 COG4748@1|root,COG4748@2|Bacteria,4NDZX@976|Bacteroidetes,1HXGR@117743|Flavobacteriia,3ZPWW@59732|Chryseobacterium 976|Bacteroidetes L Restriction endonuclease or methylase - - - ko:K07504 - - - - ko00000 - - - HSDR_N,HSDR_N_2 k59_49691_1 1165841.SULAR_08904 3.68e-78 238.0 COG3381@1|root,COG3381@2|Bacteria,1N4MX@1224|Proteobacteria,42RVB@68525|delta/epsilon subdivisions,2YP5X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S component of anaerobic - - - - - - - - - - - - Nitrate_red_del k59_117211_1 864069.MicloDRAFT_00002930 8.24e-47 158.0 COG3335@1|root,COG3335@2|Bacteria,1MXYQ@1224|Proteobacteria,2TSX4@28211|Alphaproteobacteria,1JYEX@119045|Methylobacteriaceae 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_934652_1 1123230.ARQJ01000003_gene1063 1.65e-17 75.5 2DQE0@1|root,33689@2|Bacteria,1VH8J@1239|Firmicutes,4I062@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_575012_1 1168034.FH5T_06140 7.8e-17 79.7 COG2067@1|root,COG2067@2|Bacteria,4NEP1@976|Bacteroidetes,2FN33@200643|Bacteroidia 976|Bacteroidetes I Psort location OuterMembrane, score - - - - - - - - - - - - Toluene_X k59_575012_2 1168034.FH5T_06145 1.71e-53 174.0 COG1521@1|root,COG1521@2|Bacteria,4NE9E@976|Bacteroidetes,2FMPK@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_770677_1 2340.JV46_21960 3.75e-105 333.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_705474_1 765914.ThisiDRAFT_2315 3.77e-117 371.0 COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_673713_1 1005048.CFU_0494 1.92e-52 182.0 COG0526@1|root,COG0526@2|Bacteria,1MWU8@1224|Proteobacteria,2VPNK@28216|Betaproteobacteria,475CR@75682|Oxalobacteraceae 28216|Betaproteobacteria M Thioredoxin-like - - - - - - - - - - - - Thioredoxin_2,Thioredoxin_7 k59_150842_1 105559.Nwat_0563 2.35e-105 313.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_13753_2 1122179.KB890447_gene255 1.57e-30 121.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IWHI@117747|Sphingobacteriia 976|Bacteroidetes M Tricorn protease PDZ domain - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_216021_1 387093.SUN_1302 3.77e-26 111.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,43AER@68525|delta/epsilon subdivisions,2YR8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M TIGRFAM YD repeat protein - - - - - - - - - - - - RHS_repeat k59_510758_1 1168034.FH5T_06485 3.05e-121 369.0 COG3291@1|root,COG4447@1|root,COG3291@2|Bacteria,COG4447@2|Bacteria,4NGJJ@976|Bacteroidetes,2FRXF@200643|Bacteroidia 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - - k59_1031536_1 1230341.MJ3_09313 5.26e-56 184.0 COG1215@1|root,COG1215@2|Bacteria,1V1CB@1239|Firmicutes,4HHH7@91061|Bacilli 91061|Bacilli M Glycosyl transferase family 2 wcaA - - - - - - - - - - - Glycos_transf_2 k59_575032_2 572480.Arnit_2408 1.97e-30 119.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2YMW2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_117227_2 160488.PP_4928 9.85e-35 131.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1YWN9@136845|Pseudomonas putida group 1236|Gammaproteobacteria M glycosyl transferase group 1 waaA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 iECNA114_1301.ECNA114_3778,iUMNK88_1353.UMNK88_4417 Glycos_transf_1,Glycos_transf_N k59_967003_1 997829.HMPREF1121_01762 2.44e-22 95.1 COG0484@1|root,COG0484@2|Bacteria,4NF41@976|Bacteroidetes,2FPHH@200643|Bacteroidia,22WBJ@171551|Porphyromonadaceae 976|Bacteroidetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_967003_2 754477.Q7C_2144 9.7e-41 151.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,45ZPN@72273|Thiotrichales 72273|Thiotrichales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_13783_1 640081.Dsui_1454 9.16e-17 86.7 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,2VQGZ@28216|Betaproteobacteria,2KYI0@206389|Rhodocyclales 206389|Rhodocyclales PT Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese,cNMP_binding k59_443044_2 572477.Alvin_1885 2.69e-66 218.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1WW0S@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, delta' - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_84192_1 326298.Suden_0799 1.39e-183 546.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YMMN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_183524_1 765914.ThisiDRAFT_2714 5.18e-15 81.3 COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1WXWT@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_347269_1 177437.HRM2_10270 2.53e-99 315.0 COG0531@1|root,COG0531@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease,SLC12 k59_183530_1 65393.PCC7424_0176 3.73e-50 173.0 COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria,3KH6U@43988|Cyanothece 1117|Cyanobacteria E PFAM amino acid permease-associated region - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_183530_2 977880.RALTA_A2260 3.38e-25 100.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHZW@28216|Betaproteobacteria,1K11F@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM band 7 protein - - - - - - - - - - - - Band_7 k59_312277_1 314278.NB231_16013 5.53e-28 113.0 2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1WXMV@135613|Chromatiales 135613|Chromatiales S membrane - - - - - - - - - - - - DUF2232 k59_510775_1 1121930.AQXG01000004_gene2982 1.17e-34 127.0 COG0657@1|root,COG0657@2|Bacteria,4NGAF@976|Bacteroidetes 976|Bacteroidetes I Protein of unknown function (DUF1460) - - - - - - - - - - - - DUF1460 k59_410936_1 331678.Cphamn1_2543 6.47e-106 333.0 COG0610@1|root,COG0610@2|Bacteria 2|Bacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_640620_1 62928.azo2323 6.42e-21 92.4 COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,2WEG0@28216|Betaproteobacteria,2KYGY@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_640620_2 388051.AUFE01000003_gene666 1.8e-11 65.5 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the DegT DnrJ EryC1 family wlbC - 2.6.1.98 ko:K13017 ko00520,map00520 - R10141 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_1000055_1 563040.Saut_1407 4.46e-22 95.1 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2YN93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH anthranilate synthase component trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP1282 Anth_synt_I_N,Chorismate_bind k59_1000055_2 563040.Saut_1406 2.61e-50 169.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,42W4N@68525|delta/epsilon subdivisions 1224|Proteobacteria D Sporulation related domain ftsN - - ko:K03591,ko:K03749 - - - - ko00000,ko03036 - - - SPOR k59_1000055_3 709032.Sulku_1162 8.77e-83 247.0 COG4951@1|root,COG4951@2|Bacteria,1PC94@1224|Proteobacteria,42NUB@68525|delta/epsilon subdivisions,2YMWW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Domain of unknown function (DUF1882) - - - - - - - - - - - - DUF1882 k59_312280_1 1165841.SULAR_00205 2.58e-245 683.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2YMAP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_934679_1 1454004.AW11_02489 2.7e-41 144.0 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,2VTJU@28216|Betaproteobacteria 28216|Betaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_312282_1 1042377.AFPJ01000015_gene1595 1.95e-63 211.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,46C30@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Flavin containing amine oxidoreductase - - 1.3.99.23 ko:K09516 ko00830,map00830 - R07163 RC01835 ko00000,ko00001,ko01000 - - - Amino_oxidase,FAD_binding_6,NAD_binding_1,NAD_binding_8 k59_1000060_1 709032.Sulku_1143 4.45e-93 295.0 COG1629@1|root,COG4771@2|Bacteria,1MXY7@1224|Proteobacteria,42MSN@68525|delta/epsilon subdivisions,2YN7D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_575067_1 1385513.N780_05125 1.52e-76 241.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,4HAIV@91061|Bacilli,2YA39@289201|Pontibacillus 91061|Bacilli O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11,1.8.4.12 ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_608023_1 1288494.EBAPG3_1320 0.000229 44.7 COG1205@1|root,COG1205@2|Bacteria,1QDCY@1224|Proteobacteria,2WA1A@28216|Betaproteobacteria,374J9@32003|Nitrosomonadales 28216|Betaproteobacteria L DEAD-like helicases superfamily - - - ko:K06877 - - - - ko00000 - - - DEAD k59_608023_2 2340.JV46_25240 1.71e-30 113.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RXB4@1236|Gammaproteobacteria,1JAMN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - - - - - - - - - - - LexA_DNA_bind,Peptidase_S24 k59_839833_2 795666.MW7_0779 8.97e-18 76.3 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2VVV9@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfurtransferase - - - - - - - - - - - - DUF2892 k59_251397_1 439235.Dalk_1508 9.53e-65 207.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,42NJR@68525|delta/epsilon subdivisions,2WKAM@28221|Deltaproteobacteria,2MJHK@213118|Desulfobacterales 28221|Deltaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_578690_2 660470.Theba_1526 4.09e-25 95.9 COG0695@1|root,COG0695@2|Bacteria,2GD7W@200918|Thermotogae 200918|Thermotogae O glutaredoxin-like protein, YruB-family - - - - - - - - - - - - Glutaredoxin k59_514668_1 1121448.DGI_2643 4.68e-81 253.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_350892_1 1192034.CAP_0825 4.25e-30 122.0 COG2133@1|root,COG3055@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - - k59_88103_2 631362.Thi970DRAFT_03961 4.49e-155 444.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1WWNM@135613|Chromatiales 135613|Chromatiales H Belongs to the FPP GGPP synthase family - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_88103_3 1049564.TevJSym_aa00520 8.93e-56 175.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1J6G6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_316008_2 159087.Daro_2402 4.29e-80 250.0 COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,2WFJ1@28216|Betaproteobacteria,2KVGN@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the UDP-N-acetylglucosamine 2-epimerase family mnaA - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_740771_1 33035.JPJF01000024_gene3211 2.04e-67 220.0 COG1609@1|root,COG1609@2|Bacteria,1VT4I@1239|Firmicutes,24YJ2@186801|Clostridia 186801|Clostridia K Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_4 k59_740771_2 1173027.Mic7113_4114 1.2e-25 105.0 COG2755@1|root,COG2755@2|Bacteria,1G31T@1117|Cyanobacteria,1HBTP@1150|Oscillatoriales 1117|Cyanobacteria E GDSL-like lipase acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 k59_740771_3 572544.Ilyop_1209 1.11e-12 65.5 COG1550@1|root,COG1550@2|Bacteria,37CJB@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF503) - - - ko:K09764 - - - - ko00000 - - - DUF503 k59_740771_4 350688.Clos_0675 3.53e-70 216.0 COG2077@1|root,COG2077@2|Bacteria,1V474@1239|Firmicutes,24HUY@186801|Clostridia,36IGK@31979|Clostridiaceae 186801|Clostridia O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k59_514688_1 709032.Sulku_1004 5.49e-41 139.0 COG0347@1|root,COG0347@2|Bacteria 2|Bacteria K Belongs to the P(II) protein family glnB - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_514688_2 1249480.B649_06945 2.26e-12 65.9 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2YMXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins - - - ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N k59_970710_3 526218.Sterm_1008 3.11e-106 311.0 COG2082@1|root,COG2082@2|Bacteria,3784W@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score 8.96 cbiC - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiC k59_938507_1 1120999.JONM01000005_gene3938 2.71e-43 149.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,2KQHE@206351|Neisseriales 206351|Neisseriales G Psort location Cytoplasmic, score 8.96 suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_938507_2 1469245.JFBG01000061_gene2329 4.64e-07 51.6 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1WVWE@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_282579_1 1168034.FH5T_18330 1.2e-64 218.0 COG0457@1|root,COG0457@2|Bacteria,4P3PK@976|Bacteroidetes 976|Bacteroidetes S Tetratricopeptide repeats - - - - - - - - - - - - - k59_154681_1 1121887.AUDK01000002_gene2149 3.02e-11 64.7 2C3R6@1|root,32RCN@2|Bacteria,4NRA0@976|Bacteroidetes,1ICW1@117743|Flavobacteriia,2NVFH@237|Flavobacterium 976|Bacteroidetes S RagB SusD family protein - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_88122_1 1537917.JU82_09145 1.21e-43 156.0 COG1256@1|root,COG1749@1|root,COG1256@2|Bacteria,COG1749@2|Bacteria,1MV2M@1224|Proteobacteria,42PBN@68525|delta/epsilon subdivisions,2YMGR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_88122_2 1172190.M947_03930 1.57e-53 172.0 2AIM0@1|root,32I9V@2|Bacteria,1Q1S6@1224|Proteobacteria,42U9Z@68525|delta/epsilon subdivisions,2YPXP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_88122_3 1249480.B649_03455 4.1e-11 59.7 2AK6X@1|root,31AX3@2|Bacteria,1Q6DV@1224|Proteobacteria,432YY@68525|delta/epsilon subdivisions,2YSIQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Anti-sigma-28 factor, FlgM - - - - - - - - - - - - FlgM k59_479956_1 371731.Rsw2DRAFT_3297 9.94e-100 301.0 COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_350930_1 469618.FVAG_02115 1.17e-85 257.0 COG1898@1|root,COG1898@2|Bacteria,379FK@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_514715_1 563040.Saut_1266 1.35e-90 282.0 COG0668@1|root,COG3206@1|root,COG0668@2|Bacteria,COG3206@2|Bacteria,1PMY3@1224|Proteobacteria,42M4K@68525|delta/epsilon subdivisions,2YMAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_382344_1 709032.Sulku_0245 3.64e-140 400.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,42M1Y@68525|delta/epsilon subdivisions,2YMJA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hydrolase aguB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_546317_1 709032.Sulku_1514 3.31e-09 56.6 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,42Z77@68525|delta/epsilon subdivisions,2YRAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_546317_2 1537917.JU82_10395 1.68e-109 318.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2YMBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins - - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_121141_1 50960.LS81_11980 6.57e-117 355.0 COG3505@1|root,COG3505@2|Bacteria,1MV1G@1224|Proteobacteria,42MMN@68525|delta/epsilon subdivisions,2YMAB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U COG3505 Type IV secretory pathway, VirD4 components - - - ko:K03205,ko:K12090 ko03070,ko05120,map03070,map05120 M00333,M00564 - - ko00000,ko00001,ko00002,ko02044 3.A.7,3.A.7.12.1 - - T4SS-DNA_transf k59_382345_1 1385517.N800_07390 2.38e-55 185.0 COG1609@1|root,COG1609@2|Bacteria,1MW7E@1224|Proteobacteria,1RNKJ@1236|Gammaproteobacteria,1X470@135614|Xanthomonadales 135614|Xanthomonadales K LacI family - - - - - - - - - - - - LacI,Peripla_BP_3 k59_282599_1 765911.Thivi_2702 1.3e-75 242.0 COG0772@1|root,COG0772@2|Bacteria,1R537@1224|Proteobacteria,1RR9J@1236|Gammaproteobacteria,1WWS3@135613|Chromatiales 135613|Chromatiales D Belongs to the SEDS family - - - - - - - - - - - - FTSW_RODA_SPOVE k59_282599_2 713587.THITH_06730 1.44e-28 108.0 COG0664@1|root,COG0664@2|Bacteria,1RD80@1224|Proteobacteria,1S4Q2@1236|Gammaproteobacteria,1WY7A@135613|Chromatiales 135613|Chromatiales T PFAM Cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding k59_774472_1 1408473.JHXO01000013_gene505 1.86e-113 338.0 COG2407@1|root,COG2407@2|Bacteria,4NFGS@976|Bacteroidetes,2FMDZ@200643|Bacteroidia 976|Bacteroidetes G L-fucose isomerase, C-terminal domain - - - - - - - - - - - - Fucose_iso_C k59_316044_1 765911.Thivi_0273 1.43e-101 320.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales 135613|Chromatiales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_53519_1 1172190.M947_01595 6.31e-68 218.0 COG2265@1|root,COG2265@2|Bacteria,1MY45@1224|Proteobacteria,43BHX@68525|delta/epsilon subdivisions,2YMEI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA) trmA - 2.1.1.35 ko:K00557 - - - - ko00000,ko01000,ko03016 - - - tRNA_U5-meth_tr k59_219748_1 1191523.MROS_1676 6.28e-12 65.9 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_219748_2 481448.Minf_1859 2.98e-10 63.5 COG0763@1|root,COG0763@2|Bacteria,46SSG@74201|Verrucomicrobia,37GGI@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_872070_1 1449050.JNLE01000003_gene750 7.71e-30 124.0 COG0209@1|root,COG0209@2|Bacteria,1TT3U@1239|Firmicutes,24C4U@186801|Clostridia,36G9Z@31979|Clostridiaceae 186801|Clostridia F TIGRFAM ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC k59_774485_1 1285586.H131_21892 7.92e-06 52.4 COG0740@1|root,COG0740@2|Bacteria,1TR2H@1239|Firmicutes,4HBZH@91061|Bacilli,3IYGP@400634|Lysinibacillus 91061|Bacilli OU Belongs to the peptidase S14 family clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_709331_1 86106.I862_06625 7.7e-27 111.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,47FGA@766|Rickettsiales 766|Rickettsiales H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_350960_2 1323663.AROI01000006_gene3000 1.14e-70 224.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_514736_1 395964.KE386496_gene3173 3.27e-28 116.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3NC5Q@45404|Beijerinckiaceae 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_514736_2 1210884.HG799462_gene8829 1.77e-14 69.3 COG0560@1|root,COG0560@2|Bacteria,2IXZ0@203682|Planctomycetes 203682|Planctomycetes E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD k59_546351_1 96561.Dole_0645 5.86e-80 270.0 COG0515@1|root,COG2199@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1R7HC@1224|Proteobacteria,43BQW@68525|delta/epsilon subdivisions 1224|Proteobacteria T PFAM GGDEF domain containing protein - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - AAA_16,CHASE2,GAF,GAF_2,GGDEF,Hpt,PAS,Pkinase,Response_reg,SBP_bac_3 k59_414515_1 1238190.AMQY01000023_gene331 8.32e-43 158.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1XI0M@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_414515_2 223283.PSPTO_1548 1.02e-34 125.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,1Z5DM@136849|Pseudomonas syringae group 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_803831_1 1415779.JOMH01000001_gene1954 3.4e-102 306.0 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1X31N@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_187259_1 1283300.ATXB01000001_gene388 2.03e-141 423.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_774503_1 572544.Ilyop_1689 2.03e-57 186.0 COG3713@1|root,COG3713@2|Bacteria,37CA2@32066|Fusobacteria 32066|Fusobacteria M MltA-interacting MipA family protein - - - - - - - - - - - - - k59_1003994_1 452637.Oter_3859 0.000963 48.1 COG2804@1|root,COG2804@2|Bacteria,46XYI@74201|Verrucomicrobia,3K8MN@414999|Opitutae 414999|Opitutae NU General secretory system II protein E domain protein - - - - - - - - - - - - T2SSE,T2SSE_N k59_316681_2 1123228.AUIH01000002_gene1604 8.44e-16 77.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1XIEV@135619|Oceanospirillales 135619|Oceanospirillales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_88896_1 220341.16503842 1.21e-05 55.5 COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,1T2KS@1236|Gammaproteobacteria,3ZM43@590|Salmonella 1236|Gammaproteobacteria M Domain of unknown function - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3 k59_741391_1 96561.Dole_0407 4.25e-84 266.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,42N0P@68525|delta/epsilon subdivisions,2WJCQ@28221|Deltaproteobacteria,2MI60@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_939060_1 709032.Sulku_1845 1.24e-294 832.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2YMHU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_939060_2 563040.Saut_1478 5.98e-22 91.7 COG1792@1|root,COG1792@2|Bacteria,1QB26@1224|Proteobacteria,42MF4@68525|delta/epsilon subdivisions,2YNT9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Rod shape-determining protein MreC mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_88901_1 1172190.M947_02965 5.69e-82 256.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2YN9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_252223_1 243233.MCA1301 7.17e-05 44.7 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1XEGQ@135618|Methylococcales 135618|Methylococcales H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_252223_2 1125973.JNLC01000010_gene1224 3.72e-24 104.0 COG0802@1|root,COG3178@1|root,COG0802@2|Bacteria,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,3JTQ1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Threonylcarbamoyl adenosine biosynthesis protein TsaE MA20_24090 - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH,TsaE k59_872755_1 1121405.dsmv_0071 3.13e-79 251.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,2MHP6@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Pyridine nucleotide-disulphide oxidoreductase, FAD NAD(P)-binding domain, pyridine nucleotide-disulfide oxidoreductase dimerization region, FAD-dependent pyridine nucleotide-disulfide oxidoreductase lpdA-1 - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_612598_1 190486.XAC2796 2.95e-46 167.0 COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X3WH@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_447585_1 1537917.JU82_01915 1.24e-126 377.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,42KZC@68525|delta/epsilon subdivisions,2YM82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_515416_2 1280689.AUJC01000002_gene823 5.88e-14 71.2 COG5652@1|root,COG5652@2|Bacteria,1VF6Q@1239|Firmicutes,24QQ8@186801|Clostridia,36N1D@31979|Clostridiaceae 186801|Clostridia S PFAM VanZ family protein - - - - - - - - - - - - VanZ k59_480586_1 1165841.SULAR_05588 1.16e-69 226.0 COG4942@1|root,COG4942@2|Bacteria,1QV6K@1224|Proteobacteria,42M9V@68525|delta/epsilon subdivisions,2YMS7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_54211_1 1168034.FH5T_18905 6.61e-62 197.0 COG5523@1|root,COG5523@2|Bacteria,4NM5R@976|Bacteroidetes 976|Bacteroidetes S integral membrane protein - - - - - - - - - - - - DUF975 k59_54211_2 1168034.FH5T_18910 3.04e-25 104.0 COG0823@1|root,COG0823@2|Bacteria,4NGPR@976|Bacteroidetes,2FNGJ@200643|Bacteroidia 976|Bacteroidetes U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - - k59_872764_1 1150469.RSPPHO_03163 2.04e-97 291.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,2TQUF@28211|Alphaproteobacteria,2JQGV@204441|Rhodospirillales 204441|Rhodospirillales E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metAA - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_1004614_2 287.DR97_2870 2e-52 172.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1YEDQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_316701_1 1454007.JAUG01000063_gene261 3.49e-19 89.0 COG0438@1|root,COG0438@2|Bacteria,4NITH@976|Bacteroidetes,1ITVN@117747|Sphingobacteriia 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_121936_1 1283300.ATXB01000001_gene2403 6.9e-70 228.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales 135618|Methylococcales S AAA-like domain - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 k59_316706_1 929558.SMGD1_0934 5.23e-17 80.1 COG0667@1|root,COG0667@2|Bacteria,1RHYD@1224|Proteobacteria,42SEU@68525|delta/epsilon subdivisions,2YT8N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_316706_2 1537917.JU82_01800 7.49e-65 199.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2YPKU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_316706_3 1537917.JU82_01805 1.01e-166 472.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2YM93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_612630_1 713587.THITH_10605 3.19e-42 147.0 COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,1S4JK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C fumarate reductase respiratory complex transmembrane subunit - - - ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_159393_1 1185766.DL1_04075 4.49e-58 194.0 COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,2TR44@28211|Alphaproteobacteria,2XKMY@285107|Thioclava 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain regM - - - - - - - - - - - HATPase_c,HisKA k59_223540_2 880072.Desac_0816 2.55e-70 224.0 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Cysteine-rich - - - - - - - - - - - - CCG,Fer4_17 k59_57645_1 207559.Dde_1858 6.34e-113 332.0 COG1715@1|root,COG1715@2|Bacteria,1R4NQ@1224|Proteobacteria,43B1F@68525|delta/epsilon subdivisions,2X6FN@28221|Deltaproteobacteria,2MH2I@213115|Desulfovibrionales 28221|Deltaproteobacteria L HB1, ASXL, restriction endonuclease HTH domain - - - ko:K07448 - - - - ko00000,ko02048 - - - HARE-HTH,Mrr_cat k59_191199_1 1265505.ATUG01000002_gene2570 4e-57 194.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2MI2W@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_1434 Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_21889_1 999141.GME_10146 2.26e-74 229.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1XHIV@135619|Oceanospirillales 135619|Oceanospirillales T phosphate regulon transcriptional regulatory protein PhoB phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_550547_2 754476.Q7A_1253 2.4e-49 159.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,460ZG@72273|Thiotrichales 72273|Thiotrichales S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_550547_3 187272.Mlg_1508 4.97e-105 307.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1WY1A@135613|Chromatiales 135613|Chromatiales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_319578_1 1049564.TevJSym_bc00360 8e-75 233.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1JB7M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NiFe/NiFeSe hydrogenase small subunit C-terminal - - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_319578_2 1049564.TevJSym_bc00370 9.47e-17 77.4 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_319579_1 385682.AFSL01000035_gene2929 1.95e-34 135.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FM3B@200643|Bacteroidia,3XIKJ@558415|Marinilabiliaceae 976|Bacteroidetes V MMPL family czcA - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_583021_1 933262.AXAM01000010_gene1402 3.01e-58 190.0 COG0484@1|root,COG0705@1|root,COG0484@2|Bacteria,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2MI6P@213118|Desulfobacterales 28221|Deltaproteobacteria O Rhomboid family - - - ko:K07059 - - - - ko00000 - - - DnaJ_C,Rhomboid k59_286872_1 1122212.AULO01000010_gene210 3.1e-42 150.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XHMY@135619|Oceanospirillales 135619|Oceanospirillales IQ catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP fabB - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_286872_2 1042375.AFPL01000006_gene2978 9.01e-90 266.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,4657R@72275|Alteromonadaceae 1236|Gammaproteobacteria I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_681462_1 981384.AEYW01000028_gene4249 1.21e-71 228.0 COG1409@1|root,COG1409@2|Bacteria,1NI34@1224|Proteobacteria 1224|Proteobacteria S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_843404_1 234267.Acid_1972 2.02e-23 105.0 COG1028@1|root,COG2070@1|root,COG3266@1|root,COG3321@1|root,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3266@2|Bacteria,COG3321@2|Bacteria,3Y347@57723|Acidobacteria 57723|Acidobacteria Q Acyl transferase domain - - - - - - - - - - - - ADH_zinc_N,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_354475_1 97139.C824_02320 1.4e-16 84.0 COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,249VZ@186801|Clostridia,36EYU@31979|Clostridiaceae 186801|Clostridia P Belongs to the bacterial solute-binding protein 9 family - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_159410_1 177437.HRM2_19670 6.45e-55 193.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,42M2D@68525|delta/epsilon subdivisions,2WJU6@28221|Deltaproteobacteria,2MIV6@213118|Desulfobacterales 28221|Deltaproteobacteria M Lipopolysaccharide biosynthesis protein - - - - - - - - - - - - GNVR,Wzz k59_843408_1 262768.PAM_492 4.2e-08 53.1 2B9ZZ@1|root,323DM@2|Bacteria,3WUUY@544448|Tenericutes 544448|Tenericutes S COG NOG15344 non supervised orthologous group - - - - - - - - - - - - - k59_615717_1 1123487.KB892868_gene1204 8.36e-97 305.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KUY0@206389|Rhodocyclales 206389|Rhodocyclales S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yheS - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_713198_1 709032.Sulku_0666 4.33e-148 427.0 COG0045@1|root,COG0045@2|Bacteria,1PYM0@1224|Proteobacteria,42NR1@68525|delta/epsilon subdivisions,2YMG6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the succinate malate CoA ligase beta subunit family - - 2.3.3.8 ko:K15231 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Citrate_bind k59_648532_1 395963.Bind_0957 6.54e-57 191.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TT6V@28211|Alphaproteobacteria,3NAEW@45404|Beijerinckiaceae 28211|Alphaproteobacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_451562_3 690850.Desaf_2292 3.42e-08 55.5 COG4625@1|root,COG4625@2|Bacteria,1N0QY@1224|Proteobacteria,4314D@68525|delta/epsilon subdivisions,2WWK5@28221|Deltaproteobacteria 28221|Deltaproteobacteria S pathogenesis - - - - - - - - - - - - - k59_354480_2 1410624.JNKK01000032_gene42 1.32e-57 189.0 COG0673@1|root,COG0673@2|Bacteria,1UZEK@1239|Firmicutes,24AR9@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_483015_1 2340.JV46_27140 9.24e-78 244.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0006457,GO:0008150,GO:0009987 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_57681_2 572544.Ilyop_1780 4.55e-184 520.0 COG0502@1|root,COG0502@2|Bacteria,379SY@32066|Fusobacteria 32066|Fusobacteria C Elongator protein 3, MiaB family, Radical SAM hydE - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - Fer4_12,Radical_SAM k59_57681_3 469618.FVAG_01745 6.99e-158 454.0 COG0482@1|root,COG0482@2|Bacteria,378H6@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA GO:0002097,GO:0002098,GO:0002143,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_57681_4 515635.Dtur_0719 1.45e-100 307.0 COG1104@1|root,COG1104@2|Bacteria 2|Bacteria E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_615729_1 326298.Suden_0242 2.06e-92 289.0 COG3550@1|root,COG3550@2|Bacteria,1RHBA@1224|Proteobacteria,42MXT@68525|delta/epsilon subdivisions,2YMIQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - HipA_C k59_778565_1 886379.AEWI01000210_gene2492 5.81e-83 273.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,2FWS8@200643|Bacteroidia,3XJF3@558415|Marinilabiliaceae 976|Bacteroidetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_387664_1 1198232.CYCME_2297 5.05e-122 363.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,460AZ@72273|Thiotrichales 72273|Thiotrichales C Cytochrome bd terminal oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_942936_1 572544.Ilyop_1516 1.26e-79 251.0 COG0696@1|root,COG0696@2|Bacteria,378G0@32066|Fusobacteria 32066|Fusobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_713710_3 1292373.H640_01111 2.41e-40 139.0 COG3727@1|root,COG3727@2|Bacteria,2IKPY@201174|Actinobacteria,4DSJ6@85009|Propionibacteriales 201174|Actinobacteria L DNA mismatch endonuclease Vsr vsr - - ko:K07458 - - - - ko00000,ko01000,ko03400 - - - DUF559,NUDIX,Vsr k59_713710_4 1121448.DGI_2027 4.41e-48 170.0 2ANHD@1|root,31DG6@2|Bacteria,1NTZK@1224|Proteobacteria,436Q8@68525|delta/epsilon subdivisions,2X1CI@28221|Deltaproteobacteria,2MESC@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of unknown function (DUF3883) - - - - - - - - - - - - DUF3883 k59_583557_1 1296415.JACC01000036_gene1133 2.82e-30 127.0 COG3266@1|root,COG3420@1|root,COG5492@1|root,COG3266@2|Bacteria,COG3420@2|Bacteria,COG5492@2|Bacteria 2|Bacteria N domain, Protein - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Beta_helix,CBM_2 k59_287385_1 398720.MED217_03055 9.07e-23 89.4 2DQQE@1|root,3382S@2|Bacteria,4NVGH@976|Bacteroidetes,1I5JM@117743|Flavobacteriia,2XKBU@283735|Leeuwenhoekiella 976|Bacteroidetes S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N k59_287385_2 1279009.ADICEAN_01323 5.75e-50 173.0 COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes,47MXY@768503|Cytophagia 976|Bacteroidetes V Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase,DUF3471 k59_22468_1 999547.KI421500_gene3533 9.2e-72 240.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria 28211|Alphaproteobacteria HJ Cyanophycin synthetase - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - CPSase_L_D2,Dala_Dala_lig_C,Mur_ligase_C,Mur_ligase_M,PGA_cap,RimK k59_843869_1 765913.ThidrDRAFT_2502 2.33e-114 335.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1WXW8@135613|Chromatiales 135613|Chromatiales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_287393_1 1121939.L861_20435 1.4e-82 256.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1XI9B@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_355070_1 395494.Galf_1437 4.69e-10 67.8 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,44W46@713636|Nitrosomonadales 28216|Betaproteobacteria Q Hemolysin-type calcium-binding region cyaA GO:0001906,GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005576,GO:0006873,GO:0006874,GO:0006875,GO:0007204,GO:0008150,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0019725,GO:0019835,GO:0030003,GO:0031640,GO:0035821,GO:0042592,GO:0044179,GO:0044364,GO:0044419,GO:0044764,GO:0048878,GO:0050801,GO:0051480,GO:0051704,GO:0051715,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0072503,GO:0072507,GO:0098771 4.6.1.1 ko:K11005,ko:K11029 ko00230,ko05133,map00230,map05133 M00575 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko02000,ko02042 1.C.11 - - Anthrax_toxA,DUF4214,HCBP_related,He_PIG,HemolysinCabind,RTX k59_287397_1 323261.Noc_0637 6.64e-37 126.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,1S9EI@1236|Gammaproteobacteria,1X1AH@135613|Chromatiales 135613|Chromatiales L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_287397_2 1250232.JQNJ01000001_gene346 2.78e-124 360.0 COG2801@1|root,COG2801@2|Bacteria,4NI3F@976|Bacteroidetes,1HZU9@117743|Flavobacteriia 976|Bacteroidetes L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_287409_1 439496.RBY4I_3468 1.14e-19 80.5 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Cold shock - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1008053_1 325777.GW15_0219020 4.74e-26 104.0 2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,1RNI9@1236|Gammaproteobacteria,1X3V8@135614|Xanthomonadales 135614|Xanthomonadales S 5'-nucleotidase - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5-nucleotidase k59_1008053_3 1115512.EH105704_14_00380 1.4e-18 81.6 COG1451@1|root,COG1451@2|Bacteria,1RDJ9@1224|Proteobacteria,1S45M@1236|Gammaproteobacteria,3XNWK@561|Escherichia 1236|Gammaproteobacteria S Specifically catalyzes the hydrolysis of UTP to UMP and diphosphate in vitro, albeit at apparently slow rate. Shows no activity towards ATP, GTP, CTP, dTTP and ITP as substrates ygjP - - ko:K07043 - - - - ko00000 - - - DUF45 k59_92875_1 929558.SMGD1_0168 3.62e-172 496.0 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2YMQS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_92875_2 1172190.M947_09410 1.14e-62 200.0 COG0212@1|root,COG0212@2|Bacteria,1RDZJ@1224|Proteobacteria,42SXM@68525|delta/epsilon subdivisions,2YPJD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_191836_1 1408439.JHXW01000003_gene1647 6.46e-84 268.0 COG0037@1|root,COG0037@2|Bacteria,378IX@32066|Fusobacteria 32066|Fusobacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS_C k59_191836_2 572544.Ilyop_1333 1.46e-182 534.0 COG0465@1|root,COG0465@2|Bacteria,378CN@32066|Fusobacteria 32066|Fusobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_909438_1 1005048.CFU_2163 9.78e-09 59.7 COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2VIDH@28216|Betaproteobacteria,4734H@75682|Oxalobacteraceae 28216|Betaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_974861_1 879212.DespoDRAFT_00037 8.18e-119 364.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2MIEG@213118|Desulfobacterales 28221|Deltaproteobacteria GT pyruvate phosphate dikinase - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_191848_1 1121459.AQXE01000017_gene2148 2.12e-41 140.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria,2MB9Y@213115|Desulfovibrionales 28221|Deltaproteobacteria H Molybdopterin guanine dinucleotide synthesis protein B mobB - 2.7.7.77 ko:K03753,ko:K13818 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - MobB,NTP_transf_3 k59_744924_1 929703.KE386491_gene1496 1.37e-23 91.3 COG0184@1|root,COG0184@2|Bacteria,4NS7U@976|Bacteroidetes,47R7H@768503|Cytophagia 976|Bacteroidetes J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_744924_2 1168034.FH5T_04590 3.11e-170 498.0 COG1185@1|root,COG1185@2|Bacteria,4NE4Q@976|Bacteroidetes,2FN5H@200643|Bacteroidia 976|Bacteroidetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_583619_1 1453503.AU05_06525 2.6e-10 67.0 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1YFEW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T 7TM diverse intracellular signalling mmoS - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,CHASE5,HATPase_c,HisKA,Response_reg k59_713751_1 1565314.OA34_09085 7.72e-106 321.0 COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,42N2D@68525|delta/epsilon subdivisions,2YNAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_483541_1 319003.Bra1253DRAFT_00068 2.44e-53 183.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3JTRC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_583621_1 926550.CLDAP_13750 4.66e-59 206.0 COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi 200795|Chloroflexi M LPXTG-motif cell wall anchor domain - - - - - - - - - - - - DUF4397 k59_191851_1 349521.HCH_02524 7.17e-75 243.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1XI2V@135619|Oceanospirillales 135619|Oceanospirillales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_320010_1 293826.Amet_4230 6.26e-41 150.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE k59_320010_2 572544.Ilyop_1345 8.97e-109 322.0 COG2374@1|root,COG2374@2|Bacteria,3789V@32066|Fusobacteria 32066|Fusobacteria S Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_287447_1 1121405.dsmv_0948 5.37e-46 169.0 COG0764@1|root,COG3321@1|root,COG0764@2|Bacteria,COG3321@2|Bacteria,1QUWM@1224|Proteobacteria,43BRB@68525|delta/epsilon subdivisions,2WJJ6@28221|Deltaproteobacteria,2MI1Q@213118|Desulfobacterales 28221|Deltaproteobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family - - - - - - - - - - - - Acyl_transf_1,Acyltransferase,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt k59_255986_1 546414.Deide_17930 4.83e-38 143.0 COG0606@1|root,COG0606@2|Bacteria,1WI18@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O ATPase with chaperone activity - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_779055_1 96561.Dole_0415 1.67e-84 262.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MWV@68525|delta/epsilon subdivisions,2WJJZ@28221|Deltaproteobacteria,2MMNZ@213118|Desulfobacterales 28221|Deltaproteobacteria S filamentation induced by cAMP protein Fic - - - - - - - - - - - - Fic,Fic_N,HTH_24 k59_682003_1 1537917.JU82_04710 3.29e-12 65.1 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,42MMC@68525|delta/epsilon subdivisions,2YMS8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the TtcA family ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_682003_2 929558.SMGD1_2399 4.61e-76 254.0 COG0674@1|root,COG1014@1|root,COG4244@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,COG4244@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2YRFR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Cyt-b5,POR,POR_N k59_519595_1 903818.KI912268_gene2385 3.42e-28 115.0 COG0277@1|root,COG0277@2|Bacteria 2|Bacteria C FAD linked oxidase domain protein - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_519595_2 909663.KI867150_gene1519 1.8e-08 54.7 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2MQT7@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.19,1.2.1.20,1.2.1.3,1.2.1.79,1.2.1.8 ko:K00128,ko:K00130,ko:K00135,ko:K00137 ko00010,ko00053,ko00071,ko00250,ko00260,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00260,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00027,M00135,M00555 R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_583643_2 1121013.P873_03705 3.8e-33 130.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1X5AZ@135614|Xanthomonadales 135614|Xanthomonadales S MMPL family - - - - - - - - - - - - MMPL k59_452348_1 1123261.AXDW01000003_gene1861 9.6e-30 122.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1X3SF@135614|Xanthomonadales 135614|Xanthomonadales U Type II secretory pathway, component HofQ pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_583644_1 1168034.FH5T_17845 1.22e-59 204.0 COG4251@1|root,COG4251@2|Bacteria,4PMMC@976|Bacteroidetes 976|Bacteroidetes T N-terminal 7TM region of histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_7TM,PAS_9 k59_355113_1 2340.JV46_14280 2.03e-163 471.0 COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - - - - - - - - - - ATP-synt_ab k59_355113_2 765912.Thimo_2264 3.49e-19 89.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales 135613|Chromatiales F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_452354_1 7070.TC012843-PA 7.8e-14 78.2 COG2114@1|root,KOG1023@2759|Eukaryota,38E22@33154|Opisthokonta,3B9DY@33208|Metazoa,3CT6K@33213|Bilateria,41UY7@6656|Arthropoda,3SI34@50557|Insecta 33208|Metazoa T Guanylate cyclase - GO:0000902,GO:0000904,GO:0001653,GO:0001763,GO:0002009,GO:0002164,GO:0003674,GO:0003824,GO:0004383,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005929,GO:0006139,GO:0006163,GO:0006164,GO:0006182,GO:0006355,GO:0006357,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0006935,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007409,GO:0007411,GO:0007424,GO:0007428,GO:0007431,GO:0007435,GO:0007525,GO:0007526,GO:0008037,GO:0008038,GO:0008045,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009605,GO:0009628,GO:0009651,GO:0009653,GO:0009791,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009975,GO:0009987,GO:0010468,GO:0010556,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0016198,GO:0016199,GO:0016829,GO:0016849,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0019932,GO:0019934,GO:0019935,GO:0022008,GO:0022612,GO:0023051,GO:0023052,GO:0030030,GO:0030154,GO:0030182,GO:0030198,GO:0030215,GO:0030425,GO:0030510,GO:0031175,GO:0031224,GO:0031226,GO:0031323,GO:0031326,GO:0032501,GO:0032502,GO:0032989,GO:0032990,GO:0034641,GO:0034654,GO:0035239,GO:0035272,GO:0035295,GO:0035556,GO:0036477,GO:0038023,GO:0040008,GO:0040011,GO:0040012,GO:0040014,GO:0040015,GO:0042221,GO:0042330,GO:0042995,GO:0043005,GO:0043025,GO:0043062,GO:0043204,GO:0043226,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044297,GO:0044425,GO:0044459,GO:0044463,GO:0044464,GO:0045926,GO:0046068,GO:0046390,GO:0046483,GO:0048468,GO:0048513,GO:0048519,GO:0048569,GO:0048580,GO:0048581,GO:0048583,GO:0048638,GO:0048640,GO:0048666,GO:0048667,GO:0048699,GO:0048729,GO:0048731,GO:0048732,GO:0048754,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050896,GO:0051093,GO:0051171,GO:0051239,GO:0051241,GO:0051252,GO:0051716,GO:0052652,GO:0055086,GO:0060089,GO:0060255,GO:0060429,GO:0060446,GO:0060541,GO:0060562,GO:0061061,GO:0061062,GO:0061064,GO:0061065,GO:0061067,GO:0061138,GO:0061564,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090092,GO:0090287,GO:0090325,GO:0090407,GO:0097447,GO:0097458,GO:0097485,GO:0097730,GO:0120025,GO:0120036,GO:0120038,GO:0120039,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000026,GO:2000112,GO:2001141 4.6.1.2 ko:K01769,ko:K12323,ko:K16573 ko00230,ko04022,ko04024,ko04270,ko04714,ko04921,ko04923,ko04924,ko04925,map00230,map04022,map04024,map04270,map04714,map04921,map04923,map04924,map04925 M00694 R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko01001,ko03036,ko04812 - - - ANF_receptor,Guanylate_cyc,Pkinase_Tyr k59_287467_1 1089439.KB902271_gene1988 2.36e-12 69.3 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,461BG@72273|Thiotrichales 72273|Thiotrichales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_846165_1 1249480.B649_11010 3.94e-94 277.0 COG1854@1|root,COG1854@2|Bacteria,1MWQF@1224|Proteobacteria,42QP7@68525|delta/epsilon subdivisions,2YNWJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) luxS - 4.4.1.21 ko:K07173 ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 M00609 R01291 RC00069,RC01929 ko00000,ko00001,ko00002,ko01000 - - - LuxS k59_846165_2 1249480.B649_11005 2.4e-20 83.6 2AK1R@1|root,31ARC@2|Bacteria,1Q601@1224|Proteobacteria,42WMW@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - k59_485851_1 1249627.D779_1368 1.87e-105 317.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_258201_1 96561.Dole_2773 1.43e-46 160.0 COG1614@1|root,COG1614@2|Bacteria,1PASY@1224|Proteobacteria,433D6@68525|delta/epsilon subdivisions,2WXEC@28221|Deltaproteobacteria,2MP32@213118|Desulfobacterales 28221|Deltaproteobacteria C CO dehydrogenase/acetyl-CoA synthase complex beta subunit - - - - - - - - - - - - CdhC k59_226581_1 1249627.D779_4003 3.88e-06 53.1 2DS07@1|root,33DXS@2|Bacteria,1QWHF@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_226581_2 1049564.TevJSym_ab01230 3.51e-37 134.0 COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_485863_1 713586.KB900536_gene1715 2.44e-42 142.0 COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1S5GE@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the bacterial histone-like protein family VL23_14575 - - - - - - - - - - - Bac_DNA_binding k59_846862_2 1353531.AZNX01000001_gene2329 1.04e-33 127.0 COG0583@1|root,COG0583@2|Bacteria,1MV06@1224|Proteobacteria,2TT94@28211|Alphaproteobacteria,4BM7A@82115|Rhizobiaceae 28211|Alphaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_421437_1 768671.ThimaDRAFT_0865 7.19e-47 169.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WZYR@135613|Chromatiales 135613|Chromatiales U Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_912372_1 382245.ASA_0173 3.47e-43 153.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1Y586@135624|Aeromonadales 135624|Aeromonadales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.113 ko:K12256 ko00330,ko01100,map00330,map01100 - R08714 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_912372_2 1469245.JFBG01000030_gene1535 6.58e-64 209.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1X0BG@135613|Chromatiales 135613|Chromatiales E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1043303_1 323261.Noc_0510 1.95e-65 213.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_227228_1 1121918.ARWE01000001_gene3375 1.42e-156 473.0 COG0323@1|root,COG0323@2|Bacteria,1R4RY@1224|Proteobacteria 1224|Proteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex - - - - - - - - - - - - HATPase_c_3 k59_455941_1 929558.SMGD1_0621 1.07e-202 594.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YNB5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_977996_1 1195236.CTER_4448 3.4e-38 135.0 COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,248EQ@186801|Clostridia,3WGNP@541000|Ruminococcaceae 186801|Clostridia S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_486603_1 864565.HMPREF0379_0292 6.2e-78 256.0 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,25R5S@186804|Peptostreptococcaceae 186801|Clostridia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_619528_1 1168034.FH5T_01555 2.04e-114 338.0 COG0348@1|root,COG0348@2|Bacteria,4NPVD@976|Bacteroidetes,2FTEY@200643|Bacteroidia 976|Bacteroidetes C FMN-binding domain protein - - - - - - - - - - - - Fer4_5 k59_289974_1 1354722.JQLS01000004_gene4190 9.88e-63 206.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria,46RN8@74030|Roseovarius 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_879361_1 929558.SMGD1_2447 1.58e-88 286.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2YMQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_322717_1 1303518.CCALI_00738 2.78e-10 60.5 2EHSB@1|root,33BI2@2|Bacteria 2|Bacteria S SdpI/YhfL protein family - - - - - - - - - - - - SdpI k59_25272_2 1319815.HMPREF0202_00594 8.52e-22 90.9 COG2121@1|root,COG2121@2|Bacteria,379T5@32066|Fusobacteria 32066|Fusobacteria S K02527 3-deoxy-D-manno-octulosonic-acid transferase - - - ko:K09778 - - - - ko00000 - - - DUF374 k59_811357_1 360107.CHAB381_0430 1.79e-32 118.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2YP63@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_811357_2 1056495.Calag_1329 3.83e-06 50.4 COG0456@1|root,arCOG00833@2157|Archaea,2XQJH@28889|Crenarchaeota 28889|Crenarchaeota S TIGRFAM ribosomal-protein-alanine acetyltransferase - GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_195028_1 1163407.UU7_02432 1.03e-60 199.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1X3SR@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_619540_1 572544.Ilyop_1415 9.67e-63 212.0 COG0058@1|root,COG0058@2|Bacteria,378HK@32066|Fusobacteria 32066|Fusobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_163024_1 563040.Saut_0568 4.73e-21 90.9 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2YMR3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_163024_2 990073.ATHU01000001_gene651 9.42e-32 112.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2YPX3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_163024_3 929558.SMGD1_0666 2.43e-22 92.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2YMN0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_811359_2 1123502.AQXD01000001_gene1101 1.64e-35 129.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1X73J@135614|Xanthomonadales 135614|Xanthomonadales Q ABC-type transport system involved in resistance to organic solvents auxiliary component - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_128538_1 388739.RSK20926_00490 8.5e-72 228.0 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,2U1PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_128538_2 1131553.JIBI01000051_gene966 2.55e-91 280.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2WBWD@28216|Betaproteobacteria,373ZW@32003|Nitrosomonadales 28216|Betaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_486638_1 765912.Thimo_3317 7.03e-122 363.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales 135613|Chromatiales G PFAM glycoside hydrolase, family 77 - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_358196_1 927658.AJUM01000047_gene2997 1e-16 80.1 29A93@1|root,2ZX9Y@2|Bacteria,4NNMP@976|Bacteroidetes,2FN4N@200643|Bacteroidia 976|Bacteroidetes S non supervised orthologous group - - - - - - - - - - - - Gcw_chp k59_358196_2 1168034.FH5T_09985 7.47e-31 110.0 COG0347@1|root,COG0347@2|Bacteria,4NQG9@976|Bacteroidetes,2FSGK@200643|Bacteroidia 976|Bacteroidetes K Belongs to the P(II) protein family glnB - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_879385_1 1121456.ATVA01000019_gene1218 2.06e-85 267.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,42KZU@68525|delta/epsilon subdivisions,2WJ6T@28221|Deltaproteobacteria,2M7RJ@213115|Desulfovibrionales 28221|Deltaproteobacteria P drug resistance transporter, EmrB QacA subfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_289998_1 1168034.FH5T_19660 4.83e-104 306.0 2BNB7@1|root,32GYU@2|Bacteria,4NQDS@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_716619_1 498211.CJA_3387 3.25e-36 140.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RXW2@1236|Gammaproteobacteria,1FHYK@10|Cellvibrio 1236|Gammaproteobacteria E Sodium:solute symporter family - - - - - - - - - - - - SSF k59_747718_1 768671.ThimaDRAFT_4053 6.54e-110 318.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1WWRN@135613|Chromatiales 135613|Chromatiales P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_811374_1 1121405.dsmv_0278 2.31e-61 204.0 COG3943@1|root,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,42MTT@68525|delta/epsilon subdivisions,2WJAP@28221|Deltaproteobacteria,2MI6M@213118|Desulfobacterales 28221|Deltaproteobacteria S Virulence protein RhuM family - - - - - - - - - - - - Fic,Virulence_RhuM k59_61382_1 395019.Bmul_5358 5.37e-40 141.0 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2VJTG@28216|Betaproteobacteria,1K25X@119060|Burkholderiaceae 28216|Betaproteobacteria K Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C k59_163042_1 472759.Nhal_2771 2.29e-21 101.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_163042_2 1144325.PMI22_00504 2.48e-14 72.8 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_486667_2 1049564.TevJSym_ac01570 1.97e-05 45.8 COG3160@1|root,COG3160@2|Bacteria 2|Bacteria K Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase rsd GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - ko:K07740 - - - - ko00000 - - - Rsd_AlgQ k59_716638_1 595460.RRSWK_00666 3.55e-25 106.0 COG0457@1|root,COG0457@2|Bacteria,2IXP3@203682|Planctomycetes 203682|Planctomycetes C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,TPR_16 k59_747732_1 944481.JAFP01000001_gene1532 1.83e-09 58.9 COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,2M713@213113|Desulfurellales 28221|Deltaproteobacteria CH Oxidoreductase NAD-binding domain nfnB - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_747732_2 1235835.C814_00686 2.41e-33 127.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WGEA@541000|Ruminococcaceae 186801|Clostridia C glutamate synthase gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_358211_2 452662.SJA_C1-23840 6.21e-62 203.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2K2E1@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the HpcH HpaI aldolase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_651588_1 1121405.dsmv_0215 2.19e-63 204.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,2MIJI@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kpsF - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_912430_1 292415.Tbd_2647 9.2e-34 118.0 COG4576@1|root,COG4576@2|Bacteria,1N7B1@1224|Proteobacteria,2VX39@28216|Betaproteobacteria,1KTBA@119069|Hydrogenophilales 119069|Hydrogenophilales CQ Ethanolamine utilisation protein EutN/carboxysome - - - - - - - - - - - - EutN_CcmL k59_912430_2 1458427.BAWN01000011_gene680 1.16e-49 158.0 COG4576@1|root,COG4576@2|Bacteria,1MZNS@1224|Proteobacteria,2VUR7@28216|Betaproteobacteria 28216|Betaproteobacteria CQ Ethanolamine utilisation protein EutN/carboxysome - - - - - - - - - - - - EutN_CcmL k59_912430_3 243159.AFE_1688 5.86e-18 84.0 28K6U@1|root,2Z9V7@2|Bacteria,1MYVN@1224|Proteobacteria,1S0GU@1236|Gammaproteobacteria,2NCI3@225057|Acidithiobacillales 225057|Acidithiobacillales S carboxysome shell carbonic anhydrase - - - - - - - - - - - - CsoSCA k59_946179_1 1255043.TVNIR_1952 1.35e-82 256.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_946179_2 713587.THITH_10365 1.74e-10 58.9 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, E subunit - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_619578_2 1123279.ATUS01000001_gene2236 8.89e-09 58.2 28PZQ@1|root,2ZCIX@2|Bacteria,1RA7M@1224|Proteobacteria,1S25R@1236|Gammaproteobacteria,1JBES@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S EF hand - - - - - - - - - - - - EF-hand_5 k59_912441_2 525898.Sdel_0381 1.89e-15 74.7 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2YMV6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_195083_1 1123277.KB893197_gene6104 4.94e-10 66.6 COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,47KTR@768503|Cytophagia 976|Bacteroidetes T Y_Y_Y domain - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_486697_3 749222.Nitsa_1766 9.99e-33 124.0 COG3409@1|root,COG3409@2|Bacteria,1R4RS@1224|Proteobacteria 1224|Proteobacteria M CHAP domain - - - - - - - - - - - - CHAP,PG_binding_1 k59_391156_1 987059.RBXJA2T_12477 1.85e-38 142.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,1KJ4K@119065|unclassified Burkholderiales 28216|Betaproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_522674_1 402612.FP2403 5.79e-35 138.0 COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes,1HYW1@117743|Flavobacteriia,2NSB2@237|Flavobacterium 976|Bacteroidetes MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_522674_2 1121896.JMLU01000040_gene2923 3.97e-14 75.5 COG1309@1|root,COG1309@2|Bacteria,4NQ99@976|Bacteroidetes,1I3T6@117743|Flavobacteriia,2NU2D@237|Flavobacterium 976|Bacteroidetes K tetR family - - - - - - - - - - - - TetR_N k59_358231_1 706587.Desti_0497 2.01e-67 219.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_1011122_1 395493.BegalDRAFT_1170 2.42e-57 180.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,46106@72273|Thiotrichales 72273|Thiotrichales P ApaG domain apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_1011122_2 395494.Galf_2812 4.55e-30 114.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,44VCX@713636|Nitrosomonadales 28216|Betaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_651617_1 521719.ATXQ01000004_gene1743 1.88e-07 55.1 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1YED4@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345 SBP_bac_3,SLT k59_486705_1 472759.Nhal_3769 2.65e-164 482.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales 135613|Chromatiales L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_554787_1 660470.Theba_2670 1.68e-24 112.0 COG0419@1|root,COG0419@2|Bacteria,2GC4P@200918|Thermotogae 200918|Thermotogae L PFAM SMC domain protein - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15,AAA_23,SbcCD_C k59_128593_1 709032.Sulku_0921 3.58e-105 333.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2YMA1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_163074_1 1476973.JMMB01000007_gene827 7.33e-73 236.0 COG3275@1|root,COG3275@2|Bacteria,1VTXF@1239|Firmicutes,25E5Z@186801|Clostridia,25S69@186804|Peptostreptococcaceae 186801|Clostridia T 5TMR of 5TMR-LYT - - 2.7.13.3 ko:K02478,ko:K07704 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 5TM-5TMR_LYT,GAF_3,HATPase_c,His_kinase k59_163074_2 1319815.HMPREF0202_00537 8.39e-43 147.0 COG3279@1|root,COG3279@2|Bacteria,378PP@32066|Fusobacteria 32066|Fusobacteria KT LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_619595_1 1537917.JU82_02585 2.34e-96 288.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2YN1U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_619595_2 1537917.JU82_03470 3.43e-12 65.1 28QM5@1|root,319KE@2|Bacteria,1Q3DZ@1224|Proteobacteria,42X5X@68525|delta/epsilon subdivisions,2YQT9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - Cytochrome_CBB3 k59_1043362_2 572544.Ilyop_1511 1e-93 282.0 COG0332@1|root,COG0332@2|Bacteria,37953@32066|Fusobacteria 32066|Fusobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_290044_1 1168034.FH5T_17495 1.57e-45 167.0 COG3299@1|root,COG3299@2|Bacteria,4NF69@976|Bacteroidetes,2FN8K@200643|Bacteroidia 976|Bacteroidetes S homolog of phage Mu protein gp47 - - - - - - - - - - - - Baseplate_J k59_879428_1 1385517.N800_06495 1.17e-05 53.1 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1X3S1@135614|Xanthomonadales 135614|Xanthomonadales H receptor btuB - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_879428_2 1172190.M947_03105 3.39e-14 71.2 COG0348@1|root,COG0348@2|Bacteria,1Q4BA@1224|Proteobacteria,42Q02@68525|delta/epsilon subdivisions,2YR7B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_10,Fer4_5 k59_522689_1 59689.scaffold_201045.1 0.0 999.0 COG0085@1|root,KOG0214@2759|Eukaryota,37HVP@33090|Viridiplantae,3G72V@35493|Streptophyta,3I0YM@3699|Brassicales 35493|Streptophyta K rna polymerase rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_522689_2 3702.ATCG00170.1 7.89e-97 312.0 COG0086@1|root,2QPYA@2759|Eukaryota,37HSD@33090|Viridiplantae,3GDVE@35493|Streptophyta,3I12Y@3699|Brassicales 35493|Streptophyta K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC2 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009295,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_290050_1 1168034.FH5T_04250 4.5e-87 280.0 COG4775@1|root,COG4775@2|Bacteria,4NE80@976|Bacteroidetes,2FM1J@200643|Bacteroidia 976|Bacteroidetes M Outer membrane protein, OMP85 family - - - - - - - - - - - - Bac_surface_Ag,POTRA k59_358245_1 279010.BL02940 2.03e-279 795.0 COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,4HB5N@91061|Bacilli,1ZART@1386|Bacillus 91061|Bacilli C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate citB GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0050789,GO:0050793,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0065007,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS06730 Aconitase,Aconitase_C k59_811426_1 1336243.JAEA01000017_gene597 3.3e-153 441.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,1JSX5@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, middle domain ivd2 - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_486732_1 247634.GPB2148_1892 1.68e-48 171.0 COG3202@1|root,COG3202@2|Bacteria,1QXXQ@1224|Proteobacteria,1S2KU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TLC ATP/ADP transporter - - - - - - - - - - - - TLC k59_912472_1 765912.Thimo_2434 1.01e-62 209.0 COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2FP@1236|Gammaproteobacteria,1WWXW@135613|Chromatiales 135613|Chromatiales C PFAM 2Fe-2S iron-sulfur cluster binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2 k59_914859_2 1165841.SULAR_00620 2.41e-32 127.0 COG4664@1|root,COG4665@1|root,COG4664@2|Bacteria,COG4665@2|Bacteria,1R4MZ@1224|Proteobacteria,42MQU@68525|delta/epsilon subdivisions,2YMC7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q TRAP transporter, DctM subunit - - - - - - - - - - - - DctM,DctQ k59_1013175_1 1278309.KB907103_gene1050 1.85e-09 60.1 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1XK1Y@135619|Oceanospirillales 135619|Oceanospirillales T Universal stress protein UspA and related nucleotide-binding ydaA - - ko:K14055 - - - - ko00000 - - - Usp k59_292681_1 1049564.TevJSym_ad01320 1.91e-78 248.0 COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,1RN2Q@1236|Gammaproteobacteria,1J5M2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S A domain family that is part of the cupin metalloenzyme superfamily. ycfD GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564 1.14.11.47 ko:K18850 - - - - ko00000,ko01000,ko03009 - - - Cupin_4 k59_750347_1 626418.bglu_1g09730 1.31e-09 58.5 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,1K2QA@119060|Burkholderiaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_750347_2 396588.Tgr7_1908 4.05e-60 192.0 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria,1X0E4@135613|Chromatiales 135613|Chromatiales L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_261447_1 1122611.KB903985_gene3791 1.93e-66 214.0 COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria,4EPFD@85012|Streptosporangiales 201174|Actinobacteria M RmlD substrate binding domain - GO:0000166,GO:0003674,GO:0003824,GO:0003854,GO:0004769,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016020,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016853,GO:0016860,GO:0016863,GO:0030283,GO:0033764,GO:0036094,GO:0043167,GO:0043168,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901360,GO:1901363 1.1.1.145,1.1.1.412,5.3.3.1 ko:K16045,ko:K22320 ko00984,ko01120,map00984,map01120 - R09920 RC00146 ko00000,ko00001,ko01000 - - - 3Beta_HSD,Epimerase k59_489036_1 667632.KB890168_gene5142 7.78e-10 65.1 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VMX9@28216|Betaproteobacteria,1K0PN@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_63556_1 382245.ASA_3761 1.86e-06 55.5 COG0583@1|root,COG0583@2|Bacteria,1MWUP@1224|Proteobacteria,1RNIC@1236|Gammaproteobacteria,1Y5G8@135624|Aeromonadales 135624|Aeromonadales K transcriptional regulator, ArgP - - - ko:K05596 - - - - ko00000,ko03000,ko03036 - - - HTH_1,LysR_substrate k59_98048_1 1168034.FH5T_08910 4.13e-81 244.0 COG0712@1|root,COG0712@2|Bacteria,4NSNF@976|Bacteroidetes,2FQZ5@200643|Bacteroidia 976|Bacteroidetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_98048_2 1168034.FH5T_08915 2.08e-52 171.0 COG0711@1|root,COG0711@2|Bacteria,4NQKA@976|Bacteroidetes,2FQWH@200643|Bacteroidia 976|Bacteroidetes C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_914885_1 452637.Oter_2949 2.45e-22 99.8 COG3292@1|root,COG3292@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_784463_1 43229.XP_007727667.1 1.37e-11 64.7 COG0151@1|root,KOG0237@2759|Eukaryota,38BPB@33154|Opisthokonta,3NXWQ@4751|Fungi,3QPMK@4890|Ascomycota,20DTU@147545|Eurotiomycetes,3MS73@451870|Chaetothyriomycetidae 4751|Fungi F Phosphoribosylamine-glycine ligase ade1 GO:0003674,GO:0003824,GO:0004637,GO:0004641,GO:0006139,GO:0006144,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046112,GO:0046148,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GARS_A,GARS_C,GARS_N k59_784475_2 1165841.SULAR_07835 8.18e-61 198.0 2F58Z@1|root,33XV7@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 k59_849152_1 1217718.ALOU01000010_gene899 1.4e-21 99.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPYJ@28216|Betaproteobacteria,1KGU9@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_849155_1 1249480.B649_08370 1.09e-33 127.0 COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,43D9T@68525|delta/epsilon subdivisions,2YPAD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C FAD binding domain - - 1.3.1.111,1.3.1.83 ko:K10960 ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110 - R02063,R08754,R08755,R08756,R11226,R11518 RC00212,RC00522,RC01823 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_784497_1 675812.VHA_001654 4.07e-62 205.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XUVI@135623|Vibrionales 135623|Vibrionales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_784498_1 1423748.BALB01000005_gene643 1.06e-08 63.9 COG1404@1|root,COG1404@2|Bacteria,1TPH1@1239|Firmicutes,4HBQH@91061|Bacilli,3F3M5@33958|Lactobacillaceae 91061|Bacilli O Belongs to the peptidase S8 family prtB - 3.4.21.96 ko:K01361 - - - - ko00000,ko01000,ko01002,ko03110 - - - Inhibitor_I9,PA,Peptidase_S8,SLAP,fn3_5 k59_325592_1 1210884.HG799464_gene10405 0.000742 47.4 COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes 203682|Planctomycetes KLT Protein kinase domain - - - - - - - - - - - - Pkinase,WD40 k59_489133_2 243365.CV_0464 5.01e-07 52.0 COG2911@1|root,COG2931@1|root,COG3210@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2VIZZ@28216|Betaproteobacteria,2KRIE@206351|Neisseriales 206351|Neisseriales MQU Domain of unknown function (DUF4347) - - - - - - - - - - - - DUF4214,DUF4347 k59_424221_1 329726.AM1_2780 0.000734 41.2 COG0500@1|root,COG2226@2|Bacteria,1G0W5@1117|Cyanobacteria 1117|Cyanobacteria Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_424221_3 935863.AWZR01000006_gene1343 3.34e-07 52.8 COG2945@1|root,COG2945@2|Bacteria,1RM5Q@1224|Proteobacteria,1S4TS@1236|Gammaproteobacteria,1X5YD@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - UPF0227 k59_914931_2 765913.ThidrDRAFT_3979 9.34e-22 92.4 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales 135613|Chromatiales CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_849197_1 1274374.CBLK010000019_gene2802 1.33e-18 84.3 COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,4HAK7@91061|Bacilli,26SCJ@186822|Paenibacillaceae 91061|Bacilli C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k59_814171_1 1165841.SULAR_00425 4.91e-105 322.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2YN0E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the UbiD family menA - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0396 UbiD k59_914938_1 257363.RT0752 1.1e-24 103.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_914938_2 148304.MAPG_09972T0 1.51e-09 60.5 COG0194@1|root,KOG0707@2759|Eukaryota,38FKZ@33154|Opisthokonta,3P1VP@4751|Fungi,3QU73@4890|Ascomycota,212C4@147550|Sordariomycetes,41MU9@639021|Magnaporthales 4751|Fungi G Guanylate kinase GUK1 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046710,GO:0046711,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_849202_1 1232437.KL662077_gene1866 1.14e-125 372.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MIPI@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM carboxyl transferase - - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_27689_1 946483.Cenrod_2383 8.34e-20 93.6 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,4AIZF@80864|Comamonadaceae 28216|Betaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_27689_2 1049564.TevJSym_bd00190 8.63e-89 267.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RPKN@1236|Gammaproteobacteria,1JBV7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulatory protein, C terminal ompR GO:0000156,GO:0000160,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0035556,GO:0043565,GO:0044212,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K07659 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_489184_1 869213.JCM21142_3907 9.54e-98 293.0 COG0798@1|root,COG0798@2|Bacteria,4NFG7@976|Bacteroidetes,47M0B@768503|Cytophagia 976|Bacteroidetes P PFAM Sodium Bile acid symporter family arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_914950_1 192952.MM_1863 7.57e-25 100.0 COG1846@1|root,arCOG03177@2157|Archaea,2Y0R4@28890|Euryarchaeota,2NAYX@224756|Methanomicrobia 224756|Methanomicrobia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k59_914950_2 572544.Ilyop_1870 3.18e-176 508.0 COG0534@1|root,COG0534@2|Bacteria,3784J@32066|Fusobacteria 32066|Fusobacteria V Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - MatE k59_27715_1 1049564.TevJSym_bc00190 1.73e-73 230.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1J56S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564 - ko:K07082 - - - - ko00000 - - - YceG k59_881836_1 1049564.TevJSym_at00030 4.71e-39 141.0 28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_914981_1 1168034.FH5T_05555 9.15e-53 176.0 COG4447@1|root,COG4447@2|Bacteria,4PHZF@976|Bacteroidetes,2FZYK@200643|Bacteroidia 976|Bacteroidetes S cellulose binding - - - - - - - - - - - - - k59_292826_1 746697.Aeqsu_2340 8.56e-172 501.0 COG0210@1|root,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,1HWYD@117743|Flavobacteriia 976|Bacteroidetes L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_489223_1 3847.GLYMA15G39780.2 3.06e-29 108.0 2E7A8@1|root,2SDX2@2759|Eukaryota,37XKS@33090|Viridiplantae,3GZAY@35493|Streptophyta,4JV9P@91835|fabids 35493|Streptophyta S One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation psbK - - ko:K02712 ko00195,ko01100,map00195,map01100 - - - ko00000,ko00001,ko00194 - - - PsbK k59_849241_1 2880.D8LKC3 4.79e-07 51.6 COG4770@1|root,KOG0238@2759|Eukaryota 2759|Eukaryota I CoA carboxylase activity MCCC1 GO:0002169,GO:0003674,GO:0003824,GO:0004075,GO:0004485,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005840,GO:0006082,GO:0006520,GO:0006551,GO:0006552,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009081,GO:0009083,GO:0009374,GO:0009507,GO:0009536,GO:0009987,GO:0016043,GO:0016054,GO:0016421,GO:0016874,GO:0016879,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0022607,GO:0022626,GO:0031406,GO:0031974,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050897,GO:0051186,GO:0051259,GO:0051291,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0097159,GO:0098798,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681,GO:1902494,GO:1905202,GO:1990904 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_849241_2 522306.CAP2UW1_0728 1.69e-39 140.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2VMGA@28216|Betaproteobacteria,1KQX6@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_489227_1 876044.IMCC3088_2535 4.1e-90 286.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3IM@1236|Gammaproteobacteria,1J9GH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_489227_2 1150469.RSPPHO_00811 1.95e-09 59.7 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TRT9@28211|Alphaproteobacteria,2JPUI@204441|Rhodospirillales 204441|Rhodospirillales E Oxidative deamination of D-amino acids dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_292848_2 765912.Thimo_1128 3.14e-45 155.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria,1WWKB@135613|Chromatiales 135613|Chromatiales S PFAM Radical SAM - - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_489247_1 999541.bgla_1g35570 3.74e-54 171.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1K7MM@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the P(II) protein family glnK - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_489265_1 1415778.JQMM01000001_gene29 8.46e-61 199.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1J4SK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_325703_1 1168034.FH5T_19515 9.24e-14 69.7 2E5XB@1|root,330M9@2|Bacteria,4NW0P@976|Bacteroidetes,2FS56@200643|Bacteroidia 976|Bacteroidetes S COG NOG30135 non supervised orthologous group - - - - - - - - - - - - DUF4251 k59_63732_1 1286106.MPL1_02603 1.4e-115 346.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,4608H@72273|Thiotrichales 72273|Thiotrichales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_849283_1 360107.CHAB381_1289 6.11e-07 51.6 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2YMBD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1013366_1 1449337.JQLL01000001_gene1460 2.39e-26 112.0 COG1461@1|root,COG1461@2|Bacteria,1TR6J@1239|Firmicutes,4HC2T@91061|Bacilli,27FTN@186828|Carnobacteriaceae 91061|Bacilli S Dak2 yfhG - - ko:K07030 - - - - ko00000 - - - Dak2,DegV k59_489306_2 1313421.JHBV01000031_gene1345 1.84e-27 107.0 COG3967@1|root,COG3967@2|Bacteria,4NJDN@976|Bacteroidetes,1IS2M@117747|Sphingobacteriia 976|Bacteroidetes M Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K14189 - - - - ko00000,ko01000 - - - adh_short k59_27814_1 709032.Sulku_1209 3.12e-29 120.0 COG0419@1|root,COG0419@2|Bacteria,1Q57D@1224|Proteobacteria,42NIY@68525|delta/epsilon subdivisions,2YNHQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L P-loop containing region of AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_814280_1 56780.SYN_01419 9.17e-42 150.0 COG0301@1|root,COG1293@1|root,COG0301@2|Bacteria,COG1293@2|Bacteria,1N1R1@1224|Proteobacteria,42MQ9@68525|delta/epsilon subdivisions,2WJPN@28221|Deltaproteobacteria,2MR7P@213462|Syntrophobacterales 28221|Deltaproteobacteria H Domain of unknown function (DUF814) - - - - - - - - - - - - DUF814,ThiI k59_915091_1 296591.Bpro_1513 9.05e-13 68.9 COG3971@1|root,COG3971@2|Bacteria,1RGHI@1224|Proteobacteria,2VRTF@28216|Betaproteobacteria,4AE62@80864|Comamonadaceae 28216|Betaproteobacteria Q 2-Keto-4-pentenoate hydratase - - - - - - - - - - - - FAA_hydrolase k59_915091_2 556268.OFAG_01409 2.39e-10 60.5 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,473JN@75682|Oxalobacteraceae 28216|Betaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_424378_1 99598.Cal7507_5435 1.1e-22 98.2 COG1819@1|root,COG1819@2|Bacteria,1G036@1117|Cyanobacteria,1HR6B@1161|Nostocales 1117|Cyanobacteria CG PFAM UDP-glucoronosyl and UDP-glucosyl transferase - - 2.4.1.173 ko:K05841 - - - - ko00000,ko01000,ko01003 - GT1 - Glyco_transf_28,UDPGT k59_325739_1 709032.Sulku_0652 5.71e-77 233.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,42RMF@68525|delta/epsilon subdivisions,2YPMK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_915103_1 387093.SUN_1980 5.29e-159 451.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,42N99@68525|delta/epsilon subdivisions,2YMDU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_27838_2 1268239.PALB_30640 1.64e-39 147.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,2PZQ5@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Anticodon_1,tRNA-synt_1g,tRNA_bind k59_750642_1 1121878.AUGL01000031_gene3505 9.24e-63 204.0 COG0131@1|root,COG0241@1|root,COG0131@2|Bacteria,COG0241@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Histidine biosynthesis bifunctional protein HisB hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iUMNK88_1353.UMNK88_2570 Hydrolase_like,IGPD,PNK3P k59_489361_1 933262.AXAM01000013_gene1322 7.06e-18 77.8 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42VQ6@68525|delta/epsilon subdivisions,2WRTU@28221|Deltaproteobacteria,2MKPU@213118|Desulfobacterales 28221|Deltaproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_489361_2 1304885.AUEY01000022_gene3418 1.03e-32 116.0 COG1550@1|root,COG1550@2|Bacteria,1N2H7@1224|Proteobacteria,42UCZ@68525|delta/epsilon subdivisions,2WR50@28221|Deltaproteobacteria,2MKM4@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF503) - - - ko:K09764 - - - - ko00000 - - - DUF503 k59_915139_1 504472.Slin_5475 2.81e-54 179.0 COG0134@1|root,COG0134@2|Bacteria,4NFJT@976|Bacteroidetes,47JRX@768503|Cytophagia 976|Bacteroidetes E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_489376_2 390235.PputW619_4360 1.31e-65 207.0 COG3639@1|root,COG3639@2|Bacteria,1N3HU@1224|Proteobacteria,1TKEF@1236|Gammaproteobacteria,1YUW1@136845|Pseudomonas putida group 1236|Gammaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_814329_1 639282.DEFDS_0463 1.38e-22 99.8 COG3808@1|root,COG3808@2|Bacteria,2GFAJ@200930|Deferribacteres 200930|Deferribacteres C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_981195_1 667632.KB890198_gene1074 1.96e-56 186.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,1K0ZE@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_294776_1 644282.Deba_1111 3.52e-73 235.0 COG1042@1|root,COG1042@2|Bacteria,1R8BC@1224|Proteobacteria,42PM4@68525|delta/epsilon subdivisions,2WM46@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM CoA binding domain - - 6.2.1.13 ko:K01905 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - CoA_binding_2,Succ_CoA_lig k59_360206_1 393595.ABO_0815 7.99e-51 177.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XICI@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04691,ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_65931_1 1204537.K4JRJ4_9CAUD 3.96e-17 85.5 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0044423,GO:0046806 - - - - - - - - - - - k59_164062_1 765911.Thivi_3071 6.27e-96 305.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1WX2T@135613|Chromatiales 135613|Chromatiales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_523614_1 1168034.FH5T_10710 1.59e-71 228.0 COG1538@1|root,COG1538@2|Bacteria,4NEEN@976|Bacteroidetes,2FM98@200643|Bacteroidia 976|Bacteroidetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_425499_2 1869.MB27_21030 9.85e-12 62.8 COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria 201174|Actinobacteria P sulfurtransferase - - - - - - - - - - - - Rhodanese k59_981202_1 575590.HMPREF0156_01430 1.15e-30 125.0 COG0675@1|root,COG0675@2|Bacteria 2|Bacteria L Transposase, IS605 OrfB family - - - ko:K07496 - - - - ko00000 - - - - k59_490848_2 1121035.AUCH01000019_gene2849 5.98e-55 178.0 COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,2W9RG@28216|Betaproteobacteria,2KYU1@206389|Rhodocyclales 206389|Rhodocyclales O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_851629_1 497964.CfE428DRAFT_4764 3.3e-55 194.0 COG0178@1|root,COG0178@2|Bacteria,46SAF@74201|Verrucomicrobia 74201|Verrucomicrobia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_491934_1 1168034.FH5T_21935 1.34e-157 468.0 COG4775@1|root,COG4775@2|Bacteria,4NE6Z@976|Bacteroidetes,2FM76@200643|Bacteroidia 976|Bacteroidetes M Outer membrane protein assembly complex, YaeT protein yaeT - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_818793_1 317936.Nos7107_3237 2.73e-06 53.1 COG3391@1|root,COG3409@1|root,COG3391@2|Bacteria,COG3409@2|Bacteria,1G33X@1117|Cyanobacteria 1117|Cyanobacteria M TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Cytochrom_D1,PG_binding_1 k59_328636_1 1380600.AUYN01000001_gene2436 2.67e-50 175.0 COG2936@1|root,COG2936@2|Bacteria,4NHGT@976|Bacteroidetes,1HYGE@117743|Flavobacteriia 976|Bacteroidetes S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - 3.4.14.11 ko:K01281 - - - - ko00000,ko01000,ko01002 - - - PepX_C,Peptidase_S15 k59_328636_2 1122225.AULQ01000001_gene1441 3.33e-32 125.0 COG0308@1|root,COG0308@2|Bacteria,4NGUB@976|Bacteroidetes,1HXVD@117743|Flavobacteriia 976|Bacteroidetes E peptidase M1 - - - - - - - - - - - - Peptidase_M1 k59_982145_1 272942.RCAP_rcc00035 3.25e-54 173.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2TRRE@28211|Alphaproteobacteria,1FCJA@1060|Rhodobacter 28211|Alphaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_982145_2 388739.RSK20926_08637 6.92e-38 137.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,2P1SE@2433|Roseobacter 28211|Alphaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_524677_1 572544.Ilyop_1354 3.76e-19 94.4 COG2217@1|root,COG2217@2|Bacteria,378U0@32066|Fusobacteria 32066|Fusobacteria P Psort location CytoplasmicMembrane, score 10.00 cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase k59_590058_1 338969.Rfer_0173 1.51e-35 125.0 COG3874@1|root,COG3874@2|Bacteria,1N4RT@1224|Proteobacteria 1224|Proteobacteria S Sporulation protein YtfJ (Spore_YtfJ) - - - - - - - - - - - - Spore_YtfJ k59_753376_1 1168034.FH5T_17505 4.85e-49 177.0 COG0419@1|root,COG0419@2|Bacteria,4PN9E@976|Bacteroidetes 976|Bacteroidetes L oxidoreductase activity - - - - - - - - - - - - - k59_557503_1 566466.NOR53_2879 4.06e-24 102.0 COG1502@1|root,COG1502@2|Bacteria,1NVR8@1224|Proteobacteria 1224|Proteobacteria I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_557503_2 877415.JNJQ01000018_gene1215 0.000348 48.9 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,3VQF3@526524|Erysipelotrichia 526524|Erysipelotrichia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18 k59_1242_1 720554.Clocl_0049 4.36e-43 152.0 COG2304@1|root,COG2304@2|Bacteria,1UUFN@1239|Firmicutes,24B06@186801|Clostridia,3WIA1@541000|Ruminococcaceae 186801|Clostridia S Aerotolerance regulator N-terminal - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA k59_1242_3 469618.FVAG_00909 3.05e-103 308.0 COG1721@1|root,COG1721@2|Bacteria,379T0@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1242_4 469617.FUAG_02211 1.2e-144 417.0 COG0714@1|root,COG0714@2|Bacteria,379JE@32066|Fusobacteria 32066|Fusobacteria S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1242_5 994573.T472_0207685 3.34e-54 173.0 COG1504@1|root,COG1504@2|Bacteria,1VQ3G@1239|Firmicutes,24W0D@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 k59_426451_1 1168034.FH5T_08845 1.68e-291 831.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FRGY@200643|Bacteroidia 976|Bacteroidetes V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_655551_1 1123279.ATUS01000001_gene1132 3.94e-57 191.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1J4KY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - iPC815.YPO2896,iYL1228.KPN_02862 Aminotran_5 k59_622685_1 926561.KB900618_gene312 5.39e-82 267.0 COG1033@1|root,COG1033@2|Bacteria 2|Bacteria S growth of symbiont in host cell - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL k59_818803_1 1165841.SULAR_05408 3.79e-12 63.2 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2YPDX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GatB Yqey family protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_99683_1 526227.Mesil_1294 8.27e-65 201.0 COG0041@1|root,COG0041@2|Bacteria,1WJ89@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_34191_1 572544.Ilyop_0540 6.55e-169 485.0 COG0552@1|root,COG0552@2|Bacteria,378GU@32066|Fusobacteria 32066|Fusobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_34191_2 572544.Ilyop_0334 1.21e-27 111.0 COG3078@1|root,COG3078@2|Bacteria 2|Bacteria P GTPase activator activity - - - - - - - - - - - - DUF3943 k59_34191_3 1319815.HMPREF0202_02002 1.56e-59 194.0 COG1214@1|root,COG1214@2|Bacteria,378WQ@32066|Fusobacteria 32066|Fusobacteria O Universal bacterial protein YeaZ yeaZ - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_34191_4 1319815.HMPREF0202_02001 6.59e-71 217.0 COG0802@1|root,COG0802@2|Bacteria,37A7Y@32066|Fusobacteria 32066|Fusobacteria S Hydrolase, P-loop family - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_34191_5 572544.Ilyop_1413 1.35e-82 248.0 COG0615@1|root,COG0615@2|Bacteria,37A0X@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose rfaE2 - 2.7.7.39 ko:K00980 ko00564,map00564 - R00856 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like k59_34191_6 572544.Ilyop_0064 2.72e-118 345.0 COG0730@1|root,COG0730@2|Bacteria,3799T@32066|Fusobacteria 32066|Fusobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_34191_7 572544.Ilyop_1414 8.66e-76 234.0 COG0494@1|root,COG0494@2|Bacteria,379I1@32066|Fusobacteria 32066|Fusobacteria L NUDIX domain - - - - - - - - - - - - NUDIX k59_328647_1 913865.DOT_5115 7.57e-55 183.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,261K8@186807|Peptococcaceae 186801|Clostridia P ATPases associated with a variety of cellular activities - - 3.6.3.29 ko:K02017,ko:K02052 ko02010,ko02024,map02010,map02024 M00189,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11,3.A.1.8 - - ABC_tran,TOBE_2 k59_557507_2 1168034.FH5T_01085 6.59e-33 118.0 COG0811@1|root,COG0811@2|Bacteria,4NVQH@976|Bacteroidetes 976|Bacteroidetes U peptide transport - - - - - - - - - - - - MotA_ExbB k59_557507_3 391587.KAOT1_12562 7.59e-47 159.0 2DBMF@1|root,2Z9YG@2|Bacteria,4NPRW@976|Bacteroidetes,1I1PP@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_688130_1 1279038.KB907339_gene1184 2.19e-71 232.0 COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2TS9Q@28211|Alphaproteobacteria,2JQA0@204441|Rhodospirillales 204441|Rhodospirillales S SbmA/BacA-like family - - - ko:K02471 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.203.11,3.A.1.203.4 - - ABC_membrane_2 k59_917038_1 547042.BACCOPRO_01514 2.56e-17 84.0 COG0704@1|root,COG0704@2|Bacteria,4NNT5@976|Bacteroidetes,2FNP4@200643|Bacteroidia,4AM4G@815|Bacteroidaceae 976|Bacteroidetes P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_361374_1 1117647.M5M_04240 7.73e-26 114.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1J512@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB mshE - - ko:K12276 ko05111,map05111 - - - ko00000,ko00001,ko02044 - - - T2SSE,T2SSE_N k59_361374_2 458233.MCCL_1726 4.47e-19 85.5 COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,4HIIF@91061|Bacilli,4GZ40@90964|Staphylococcaceae 91061|Bacilli S Threonylcarbamoyl adenosine biosynthesis protein TsaE ydiB GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_361374_3 383372.Rcas_1512 1.58e-51 198.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2G5J0@200795|Chloroflexi,374Y5@32061|Chloroflexia 32061|Chloroflexia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_851666_1 96561.Dole_0194 7.65e-87 282.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,43BQI@68525|delta/epsilon subdivisions 1224|Proteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4,1.8.5.3 ko:K00370,ko:K07306,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500,R09501 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.3,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_262875_1 1101195.Meth11DRAFT_1787 1.81e-11 63.2 COG4520@1|root,COG4520@2|Bacteria,1RIHU@1224|Proteobacteria,2VTAT@28216|Betaproteobacteria,2KNS8@206350|Nitrosomonadales 206350|Nitrosomonadales M Glycine zipper - - - - - - - - - - - - Rick_17kDa_Anti k59_66867_1 1415778.JQMM01000001_gene2182 3.82e-47 162.0 COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C ATP synthase gamma subunit - - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_66867_2 743720.Psefu_0692 9.13e-17 75.9 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1YXQQ@136845|Pseudomonas putida group 1236|Gammaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520 PgpA k59_295812_1 1094184.KWO_0120125 9.17e-30 114.0 COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,1S826@1236|Gammaproteobacteria,1X74A@135614|Xanthomonadales 135614|Xanthomonadales M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_295812_2 935863.AWZR01000003_gene2576 3.97e-13 65.9 2BH75@1|root,32B8F@2|Bacteria,1QB6K@1224|Proteobacteria,1T6QF@1236|Gammaproteobacteria,1X7EX@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_949662_1 1235990.HHS_03650 1.02e-07 49.7 COG0211@1|root,COG0211@2|Bacteria,2NPSU@2323|unclassified Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_688139_1 96561.Dole_2153 9.03e-48 169.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2WJ9Y@28221|Deltaproteobacteria,2MHRW@213118|Desulfobacterales 28221|Deltaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_328662_1 1188252.AJYK01000022_gene1367 3.17e-14 69.3 COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,1RR6R@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp k59_328662_2 1355368.JART01000002_gene2288 1.39e-68 218.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,42MJ0@68525|delta/epsilon subdivisions,2YMCZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Co Zn Cd efflux system component czcD - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux,ZT_dimer k59_818823_1 933262.AXAM01000061_gene1666 5.45e-53 186.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MIIB@213118|Desulfobacterales 28221|Deltaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_949667_1 1347393.HG726019_gene7600 1.74e-16 73.6 COG1694@1|root,COG1694@2|Bacteria,4NQ3H@976|Bacteroidetes,2FT28@200643|Bacteroidia,4AQWU@815|Bacteroidaceae 976|Bacteroidetes S MazG nucleotide pyrophosphohydrolase domain ypjD - - - - - - - - - - - MazG k59_949667_2 553177.CAPSP0001_1982 2.13e-51 166.0 COG1490@1|root,COG1490@2|Bacteria,4NNFF@976|Bacteroidetes,1I1XN@117743|Flavobacteriia,1ERU9@1016|Capnocytophaga 976|Bacteroidetes J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_590083_1 572544.Ilyop_1240 7.09e-88 266.0 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - LolA_like k59_819340_6 469616.FMAG_01253 1.4e-59 196.0 COG2302@1|root,COG2302@2|Bacteria,379I5@32066|Fusobacteria 32066|Fusobacteria S S4 RNA-binding domain - - - - - - - - - - - - S4 k59_721380_1 546275.FUSPEROL_00657 2.2e-51 176.0 COG0536@1|root,COG0536@2|Bacteria,3793K@32066|Fusobacteria 32066|Fusobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k59_721380_2 469616.FMAG_00992 0.000397 40.8 2E7IM@1|root,3320X@2|Bacteria,37AX6@32066|Fusobacteria 32066|Fusobacteria S zinc-ribbon family - - - - - - - - - - - - zinc_ribbon_15 k59_394467_1 761193.Runsl_4865 3.28e-06 48.9 COG2272@1|root,COG2272@2|Bacteria,4NG5B@976|Bacteroidetes,47JGD@768503|Cytophagia 976|Bacteroidetes I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_394467_2 1358423.N180_14655 8.66e-22 96.3 COG0702@1|root,COG0702@2|Bacteria,4PPA6@976|Bacteroidetes,1J12D@117747|Sphingobacteriia 976|Bacteroidetes GM Pfam:SusD - - - - - - - - - - - - SusD-like_3,SusD_RagB k59_819346_1 338966.Ppro_2857 6.78e-65 201.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,43BHF@68525|delta/epsilon subdivisions,2WQUJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_884516_2 387093.SUN_1389 3.38e-38 133.0 COG0701@1|root,COG0701@2|Bacteria,1NC9P@1224|Proteobacteria,42UV0@68525|delta/epsilon subdivisions,2YPSM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted permease - - - - - - - - - - - - - k59_884516_3 387093.SUN_1388 2.43e-52 171.0 COG0701@1|root,COG0701@2|Bacteria,1N00Q@1224|Proteobacteria,43BIF@68525|delta/epsilon subdivisions,2YT8R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted permease - - - - - - - - - - - - ArsP_1 k59_688686_2 285535.JOEY01000033_gene9250 2.58e-27 122.0 COG0726@1|root,COG1215@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria 201174|Actinobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Polysacc_deac_1 k59_688686_3 1408823.AXUS01000006_gene14 1.92e-103 310.0 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,25R7N@186804|Peptostreptococcaceae 186801|Clostridia J Phenylalanyl-tRNA synthetase alpha subunit pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_688686_4 1123276.KB893290_gene5334 1.31e-21 99.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,4NF5B@976|Bacteroidetes,47JAK@768503|Cytophagia 976|Bacteroidetes J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_361978_1 1249480.B649_05690 2.09e-33 126.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2YM9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_361978_2 1249480.B649_05685 1.31e-37 127.0 COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42VGZ@68525|delta/epsilon subdivisions,2YQ8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 k59_819352_1 367737.Abu_1006 3.32e-74 234.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2YM9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_34511_1 574087.Acear_1398 6.21e-89 298.0 COG2887@1|root,COG2887@2|Bacteria,1V0EQ@1239|Firmicutes,24FHF@186801|Clostridia,3WACE@53433|Halanaerobiales 186801|Clostridia L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_34511_2 1124991.MU9_93 1.18e-60 203.0 COG0524@1|root,COG0524@2|Bacteria,1MWX4@1224|Proteobacteria 1224|Proteobacteria G Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP) - - 2.7.1.3 ko:K00846 ko00051,ko01100,ko01120,map00051,map01100,map01120 - R00866,R03819 RC00002,RC00017,RC00608 ko00000,ko00001,ko01000,ko04147 - - - PfkB,Rieske k59_34511_3 572544.Ilyop_0221 2.4e-148 435.0 COG1055@1|root,COG1055@2|Bacteria,378C3@32066|Fusobacteria 32066|Fusobacteria P Arsenical pump membrane protein - - - - - - - - - - - - CitMHS k59_34511_4 572544.Ilyop_0972 9.91e-245 687.0 COG2509@1|root,COG2509@2|Bacteria,378BW@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - ko:K07137 - - - - ko00000 - - - FAD_binding_2,Pyr_redox_2 k59_34511_5 572544.Ilyop_0868 5.31e-168 486.0 COG0827@1|root,COG0827@2|Bacteria,379CB@32066|Fusobacteria 32066|Fusobacteria L TaqI-like C-terminal specificity domain - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - Eco57I,Methyltransf_31,TaqI_C k59_100270_1 395493.BegalDRAFT_1269 1.43e-24 115.0 COG0515@1|root,COG0642@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Pkinase,Response_reg k59_950247_1 1443125.Z962_08495 7.94e-100 299.0 COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,36E3G@31979|Clostridiaceae 186801|Clostridia E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS14365 CM_2,SKI,Shikimate_DH,Shikimate_dh_N k59_950247_2 1321779.HMPREF1984_00725 1.24e-102 315.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,37A05@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score 9.97 - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,PDT k59_950247_3 1540257.JQMW01000011_gene2475 8.58e-168 479.0 COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,36E36@31979|Clostridiaceae 186801|Clostridia E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_426957_1 314345.SPV1_08456 4.27e-74 242.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria 1224|Proteobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - - - - - - - - - - - XFP,XFP_N k59_950248_1 909663.KI867150_gene2799 9.03e-40 149.0 COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2MQFP@213462|Syntrophobacterales 28221|Deltaproteobacteria M Lysin motif mltD2 - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_819357_1 1121097.JCM15093_1307 6.53e-60 213.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FN3Y@200643|Bacteroidia,4AP89@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_590602_2 223926.28806978 5.72e-34 130.0 COG2515@1|root,COG2515@2|Bacteria,1R87T@1224|Proteobacteria,1RRB2@1236|Gammaproteobacteria,1XU3I@135623|Vibrionales 135623|Vibrionales E COG2515 1-aminocyclopropane-1-carboxylate deaminase - - - - - - - - - - - - PALP k59_394484_1 1123392.AQWL01000011_gene2230 2.46e-61 205.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,1KS05@119069|Hydrogenophilales 119069|Hydrogenophilales P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_623290_1 1408418.JNJH01000001_gene2996 4.78e-42 159.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2TR0H@28211|Alphaproteobacteria,2JR01@204441|Rhodospirillales 204441|Rhodospirillales KQ GAF modulated sigma54 specific transcriptional regulator, Fis family - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_884536_1 743299.Acife_1617 4.99e-25 95.9 COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,1S9F8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxin - - - - - - - - - - - - - k59_231124_1 1407650.BAUB01000002_gene477 1.66e-90 269.0 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1GYT4@1129|Synechococcus 1117|Cyanobacteria C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_1629_1 335543.Sfum_3013 1.94e-73 248.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Pyr_redox_2 k59_917696_1 1282362.AEAC466_05375 2.49e-16 86.3 COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,2TW6Q@28211|Alphaproteobacteria,2KKAI@204458|Caulobacterales 204458|Caulobacterales H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_852909_1 572544.Ilyop_1670 2.31e-76 234.0 COG1713@1|root,COG1713@2|Bacteria,379CI@32066|Fusobacteria 32066|Fusobacteria H Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_852909_2 572544.Ilyop_1669 1.32e-167 492.0 COG0557@1|root,COG0557@2|Bacteria,3783U@32066|Fusobacteria 32066|Fusobacteria K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB k59_885095_1 709032.Sulku_1592 5.88e-97 288.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2YMT4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_296923_1 1122604.JONR01000003_gene1519 1.18e-43 152.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPGB@1236|Gammaproteobacteria,1X4QM@135614|Xanthomonadales 135614|Xanthomonadales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_296923_2 1048339.KB913029_gene3271 8.15e-22 92.0 COG0426@1|root,COG0426@2|Bacteria,2GKJ9@201174|Actinobacteria,4ESHY@85013|Frankiales 201174|Actinobacteria C domain, Protein - - - - - - - - - - - - - k59_918437_1 290402.Cbei_2405 2.38e-75 252.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,36DSJ@31979|Clostridiaceae 186801|Clostridia I CoA-substrate-specific enzyme activase hgdC2 - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_885097_1 1249627.D779_1891 1.44e-82 268.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_689370_1 1453505.JASY01000002_gene2854 4.34e-49 169.0 28M32@1|root,2ZAHE@2|Bacteria,4NM0S@976|Bacteroidetes,1I7W0@117743|Flavobacteriia,2NVIX@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - WG_beta_rep k59_329939_1 1304883.KI912532_gene3057 2.08e-127 386.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,2KUV3@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.3 ko:K07306 ko00920,map00920 - R09501 RC02555 ko00000,ko00001,ko01000,ko02000 5.A.3.3 - - Molybdopterin,Molydop_binding k59_787330_2 76869.PputGB1_1330 1.01e-25 105.0 COG2267@1|root,COG2267@2|Bacteria,1MX2H@1224|Proteobacteria,1RRSX@1236|Gammaproteobacteria,1YUVZ@136845|Pseudomonas putida group 1236|Gammaproteobacteria I serine threonine protein kinase IV02_22745 - - - - - - - - - - - - k59_918440_1 876044.IMCC3088_2027 2.03e-57 192.0 COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,1RNW6@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major facilitator superfamily yjhB GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039 - - - - - - - - - - MFS_1,Sugar_tr k59_493230_1 221288.JH992901_gene3297 9.01e-26 99.4 COG0614@1|root,COG0614@2|Bacteria,1G7SF@1117|Cyanobacteria,1JITM@1189|Stigonemataceae 1117|Cyanobacteria P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_493230_2 1121033.AUCF01000013_gene1599 0.0 905.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPYX@204441|Rhodospirillales 204441|Rhodospirillales I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_493230_3 1415778.JQMM01000001_gene1070 4.62e-140 406.0 COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,1RP15@1236|Gammaproteobacteria,1J4Q4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E periplasmic protein kinase ArgK and related GTPases of G3E family argK GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111 - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_591177_3 1168059.KB899087_gene2397 5.28e-08 62.4 2BZGM@1|root,3381B@2|Bacteria,1RJ5W@1224|Proteobacteria,2UED3@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_591177_4 981383.AEWH01000038_gene1270 9.75e-85 262.0 COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli 91061|Bacilli C reductase ytbE - - - - - - - - - - - Aldo_ket_red k59_133856_1 1168034.FH5T_21275 4.03e-56 182.0 COG4974@1|root,COG4974@2|Bacteria,4NE0E@976|Bacteroidetes,2FP3B@200643|Bacteroidia 976|Bacteroidetes D tyrosine recombinase XerC xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_526030_1 292415.Tbd_2136 2.68e-15 75.1 COG3631@1|root,COG3631@2|Bacteria 2|Bacteria S light absorption - - - - - - - - - - - - SnoaL_2,SnoaL_3 k59_1016094_1 1537917.JU82_08485 1.07e-111 347.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2YMJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_950980_1 977880.RALTA_A2260 1.23e-112 330.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHZW@28216|Betaproteobacteria,1K11F@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM band 7 protein - - - - - - - - - - - - Band_7 k59_950980_2 1255043.TVNIR_2789 2.82e-14 72.8 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1WXRD@135613|Chromatiales 135613|Chromatiales O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD k59_918463_1 1168034.FH5T_17870 2.01e-101 314.0 COG1042@1|root,COG1042@2|Bacteria,4NFTI@976|Bacteroidetes,2FNSJ@200643|Bacteroidia 976|Bacteroidetes C CoA binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_296949_1 1168034.FH5T_07080 2.35e-124 372.0 COG1523@1|root,COG1523@2|Bacteria,4NIH2@976|Bacteroidetes,2FKZS@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 13 family pulA - 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 - R02111 - ko00000,ko00001,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_623916_1 981223.AIED01000006_gene3457 4.1e-63 194.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,3NNHG@468|Moraxellaceae 1236|Gammaproteobacteria K Belongs to the P(II) protein family glnK - - ko:K04752 - - - - ko00000 - - - P-II k59_623916_2 90813.JQMT01000001_gene589 3.65e-70 224.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,4600D@72273|Thiotrichales 72273|Thiotrichales P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_2019_1 572544.Ilyop_1350 3.89e-146 437.0 COG1199@1|root,COG1199@2|Bacteria,378GX@32066|Fusobacteria 32066|Fusobacteria L K03722 ATP-dependent DNA helicase DinG - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2 k59_2019_2 1216362.B437_03121 1.77e-30 110.0 COG0268@1|root,COG0268@2|Bacteria,37AP5@32066|Fusobacteria 32066|Fusobacteria J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_2019_3 195103.CPF_0572 7.52e-48 165.0 COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,36EYH@31979|Clostridiaceae 186801|Clostridia S MgtC SapB transporter - - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC k59_2019_4 66692.ABC2532 1.79e-50 170.0 COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,4HAT2@91061|Bacilli,1ZBJJ@1386|Bacillus 91061|Bacilli S protein, Hemolysin III yplQ - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_2019_5 1319815.HMPREF0202_02044 1.27e-60 203.0 COG1466@1|root,COG1466@2|Bacteria,379PU@32066|Fusobacteria 32066|Fusobacteria L DNA polymerase III - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta k59_2019_6 526218.Sterm_1929 3e-35 129.0 COG1533@1|root,COG1533@2|Bacteria,3788N@32066|Fusobacteria 32066|Fusobacteria L Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - k59_918466_1 1122164.JHWF01000010_gene2425 2.69e-70 226.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1JDTN@118969|Legionellales 118969|Legionellales M Belongs to the peptidase S11 family dacA - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_689397_1 631362.Thi970DRAFT_02298 1e-28 116.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1WWAA@135613|Chromatiales 135613|Chromatiales O peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 k59_591186_1 1173020.Cha6605_2377 1.28e-94 285.0 COG0667@1|root,COG0667@2|Bacteria,1G11W@1117|Cyanobacteria 1117|Cyanobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_100998_1 1265505.ATUG01000002_gene1060 1.41e-11 65.1 COG0834@1|root,COG5000@1|root,COG0834@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_100998_2 439235.Dalk_5071 7e-68 222.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WMEF@28221|Deltaproteobacteria,2MJFC@213118|Desulfobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_885099_3 86416.Clopa_4015 5.06e-16 73.9 COG1359@1|root,COG1359@2|Bacteria,1VJ7Y@1239|Firmicutes,24RJ7@186801|Clostridia,36MX3@31979|Clostridiaceae 186801|Clostridia S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_461293_1 749222.Nitsa_0182 1.32e-124 358.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2YT86@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Desulfoferrodoxin, N-terminal domain rrc - - - - - - - - - - - Desulfoferrod_N,Rubrerythrin k59_101541_1 997884.HMPREF1068_01544 1.15e-25 110.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,2FM06@200643|Bacteroidia,4APRB@815|Bacteroidaceae 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_362777_1 929556.Solca_4131 9.74e-20 94.4 COG2373@1|root,COG2373@2|Bacteria,4NGYZ@976|Bacteroidetes,1IQTB@117747|Sphingobacteriia 976|Bacteroidetes S Large extracellular alpha-helical protein - - - - - - - - - - - - - k59_461295_1 709991.Odosp_0247 1.31e-67 218.0 COG2884@1|root,COG2884@2|Bacteria,4NEP2@976|Bacteroidetes,2FMNR@200643|Bacteroidia,22W1P@171551|Porphyromonadaceae 976|Bacteroidetes D ABC transporter, ATP-binding protein ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_526565_1 762982.HMPREF9442_03473 2.54e-46 171.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FW53@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_330481_2 1298593.TOL_3448 7.7e-36 124.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1XKG5@135619|Oceanospirillales 135619|Oceanospirillales J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_853325_1 436114.SYO3AOP1_0962 2.53e-23 91.3 COG0011@1|root,COG0011@2|Bacteria,2G43G@200783|Aquificae 200783|Aquificae S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP k59_853325_2 580332.Slit_0335 2.84e-54 174.0 arCOG05276@1|root,3195F@2|Bacteria,1RHZA@1224|Proteobacteria,2VSYY@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_853325_3 765911.Thivi_3865 4.26e-71 225.0 COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria,1S5FF@1236|Gammaproteobacteria,1X0KV@135613|Chromatiales 135613|Chromatiales H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_853325_5 402881.Plav_1858 1.2e-144 432.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,1JPG1@119043|Rhodobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_853325_7 1049564.TevJSym_ai00870 0.0 907.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1J4VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_853325_8 1049564.TevJSym_ai00820 2.07e-48 160.0 COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1J6IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway ubiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.3.40 ko:K03181 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R01302 RC00491,RC02148 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5638 Chor_lyase k59_853325_9 1249627.D779_0941 2.52e-133 387.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales 135613|Chromatiales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_853325_10 556268.OFAG_01428 6.73e-97 287.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,473B4@75682|Oxalobacteraceae 28216|Betaproteobacteria S Phosphatidylethanolamine-binding protein bbsI - - ko:K06910 - - - - ko00000 - - - PBP k59_853325_11 1232683.ADIMK_0146 4.1e-31 113.0 2E6Y2@1|root,331HC@2|Bacteria,1N7EH@1224|Proteobacteria,1SE1K@1236|Gammaproteobacteria,4688P@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_853325_12 765912.Thimo_1261 1.12e-153 437.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WZ7F@135613|Chromatiales 135613|Chromatiales E TIGRFAM ATP phosphoribosyltransferase, C-terminal domain - - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_853325_13 204773.HEAR1250 8.25e-53 199.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,475C1@75682|Oxalobacteraceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9 k59_395657_1 1150621.SMUL_1092 7.66e-12 70.1 COG4967@1|root,COG4967@2|Bacteria,1QV0F@1224|Proteobacteria,42X5W@68525|delta/epsilon subdivisions,2YQPH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU type IV pilus modification protein PilV - - - - - - - - - - - - - k59_820521_1 709032.Sulku_0457 5.52e-05 43.9 COG1214@1|root,COG1214@2|Bacteria,1Q1J6@1224|Proteobacteria,42TUF@68525|delta/epsilon subdivisions,2YQ3R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG1214 Inactive homolog of metal-dependent proteases tsaB - - - - - - - - - - - - k59_820521_2 1537917.JU82_06735 6.27e-139 398.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2YMMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_362787_1 1384056.N787_08600 3.74e-69 224.0 COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,1RMAI@1236|Gammaproteobacteria,1X5D5@135614|Xanthomonadales 135614|Xanthomonadales H AbgT putative transporter family - - - - - - - - - - - - ABG_transport k59_68567_1 1123070.KB899252_gene915 8.81e-54 183.0 COG0697@1|root,2Z7ID@2|Bacteria 2|Bacteria EG Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) rhaT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015291,GO:0015293,GO:0015749,GO:0015762,GO:0016020,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - ko:K02856 - - - - ko00000,ko02000 2.A.7.6 - iECSE_1348.ECSE_4196,iEcE24377_1341.EcE24377A_4438,iYL1228.KPN_04216 RhaT k59_559382_1 1168034.FH5T_15090 1.72e-75 234.0 COG0679@1|root,COG0679@2|Bacteria 2|Bacteria S auxin-activated signaling pathway mdcF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.2.3 ko:K00101,ko:K07088,ko:K13936 ko00620,ko01100,map00620,map01100 - R00196 RC00044 ko00000,ko00001,ko01000,ko02000 2.A.69.2.1 - iECW_1372.ECW_m2605,iWFL_1372.ECW_m2605 Mem_trans k59_559382_2 1168034.FH5T_15095 4.3e-100 295.0 COG0637@1|root,COG0637@2|Bacteria,4NEEH@976|Bacteroidetes,2FXP5@200643|Bacteroidia 2|Bacteria S Haloacid dehalogenase-like hydrolase yqaB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008801,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 - - - - - - - - - iSF_1195.SF2717,iSFxv_1172.SFxv_2981,iS_1188.S2904 HAD_2 k59_134361_1 349161.Dred_0533 7.89e-59 190.0 COG3267@1|root,COG3267@2|Bacteria,1UZHQ@1239|Firmicutes,24EB3@186801|Clostridia 186801|Clostridia U SMART AAA ATPase - - - - - - - - - - - - AAA_22 k59_951499_1 1203606.HMPREF1526_02304 2.25e-134 386.0 COG3622@1|root,COG3622@2|Bacteria,1TRQV@1239|Firmicutes,24AGD@186801|Clostridia,36MPQ@31979|Clostridiaceae 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_951499_2 748449.Halha_2503 2.44e-172 489.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,24B6F@186801|Clostridia,3WBC8@53433|Halanaerobiales 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_362792_1 563040.Saut_1073 3.81e-12 68.2 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42PUI@68525|delta/epsilon subdivisions,2YN3E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P PFAM TrkA-N domain protein - - - - - - - - - - - - Ion_trans_2,TrkA_N k59_362792_2 697282.Mettu_2213 6.93e-13 71.6 COG0589@1|root,COG0589@2|Bacteria,1PAFP@1224|Proteobacteria,1RSCS@1236|Gammaproteobacteria,1XEKF@135618|Methylococcales 135618|Methylococcales T Universal stress protein family - - - - - - - - - - - - Usp k59_167139_2 272559.BF9343_0823 2.94e-30 122.0 COG0823@1|root,COG0823@2|Bacteria,4NGH4@976|Bacteroidetes,2FN8G@200643|Bacteroidia,4AME4@815|Bacteroidaceae 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_526590_1 999541.bgla_1g04460 8.9e-84 263.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,1K1SY@119060|Burkholderiaceae 28216|Betaproteobacteria S abc transporter yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_853337_1 1163617.SCD_n02021 2.84e-116 355.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfate transporter antisigma-factor antagonist STAS - - - - - - - - - - - - STAS,Sulfate_transp k59_919045_1 1121405.dsmv_3768 1.87e-58 186.0 COG1633@1|root,COG1633@2|Bacteria,1N4PW@1224|Proteobacteria,42UZG@68525|delta/epsilon subdivisions,2WNGQ@28221|Deltaproteobacteria,2MJYE@213118|Desulfobacterales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_330505_1 1168034.FH5T_15320 9.82e-150 449.0 COG3408@1|root,COG3408@2|Bacteria,4NESP@976|Bacteroidetes,2FMGH@200643|Bacteroidia 976|Bacteroidetes G Alpha-L-rhamnosidase N-terminal domain protein - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_788129_2 1537917.JU82_04815 4.52e-45 157.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2YMSV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E o-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_559774_1 522306.CAP2UW1_3348 7.86e-88 280.0 COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,2VKRX@28216|Betaproteobacteria 28216|Betaproteobacteria Q Male sterility - - - - - - - - - - - - NAD_binding_4,adh_short k59_363245_1 1417296.U879_13755 9.32e-25 98.2 COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2TV26@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_3 k59_363245_2 652103.Rpdx1_3154 3.91e-39 134.0 COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2U80W@28211|Alphaproteobacteria,3K5T7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_853680_1 398579.Spea_3295 3.26e-70 218.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,2Q9MA@267890|Shewanellaceae 1236|Gammaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_984210_1 1340493.JNIF01000003_gene4776 3.48e-17 80.9 COG3509@1|root,COG3509@2|Bacteria,3Y3SY@57723|Acidobacteria 57723|Acidobacteria Q Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 k59_755208_1 1506994.JNLQ01000002_gene3329 1.79e-28 118.0 COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,4BWXP@830|Butyrivibrio 186801|Clostridia D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_330926_1 998674.ATTE01000001_gene418 1.28e-51 168.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,462IQ@72273|Thiotrichales 72273|Thiotrichales CO Redoxin - - - - - - - - - - - - - k59_330926_2 2340.JV46_18390 2.96e-18 84.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cytochrome c-type biogenesis protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1016983_2 944547.ABLL_2110 7.94e-58 187.0 COG2346@1|root,COG2346@2|Bacteria,1N1UU@1224|Proteobacteria,43B84@68525|delta/epsilon subdivisions,2YRXC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_102013_1 1265503.KB905162_gene3592 3e-27 105.0 COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria,1RS8P@1236|Gammaproteobacteria,2Q71J@267889|Colwelliaceae 1236|Gammaproteobacteria O Thioredoxin VP2116 - - ko:K07396 - - - - ko00000 - - - DSBA,Thioredoxin_5 k59_951752_1 1001585.MDS_1969 1.38e-41 151.0 COG3980@1|root,COG3980@2|Bacteria,1Q330@1224|Proteobacteria,1RYTC@1236|Gammaproteobacteria,1YHEX@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Glycosyl transferase family 1 - - - - - - - - - - - - Acetyltransf_3,Glyco_tran_28_C k59_199657_1 1121935.AQXX01000129_gene1795 6.65e-110 336.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1XI2V@135619|Oceanospirillales 135619|Oceanospirillales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_853685_1 1232437.KL661972_gene4809 1.46e-18 91.7 COG2176@1|root,COG5000@1|root,COG2176@2|Bacteria,COG5000@2|Bacteria,1QUVW@1224|Proteobacteria,43AX1@68525|delta/epsilon subdivisions,2X5KH@28221|Deltaproteobacteria,2MJC4@213118|Desulfobacterales 28221|Deltaproteobacteria L EXOIII - - - - - - - - - - - - RNase_T k59_2578_1 635013.TherJR_2223 6.01e-59 205.0 COG1470@1|root,COG5276@1|root,COG1470@2|Bacteria,COG5276@2|Bacteria 2|Bacteria S cell adhesion involved in biofilm formation - - - ko:K12287 - - - - ko00000,ko02044 - - - Big_5,CarboxypepD_reg,DUF1566,He_PIG,LVIVD,SLH k59_755217_1 180332.JTGN01000003_gene2139 9.2e-53 187.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_396054_1 1121004.ATVC01000031_gene1515 1.81e-06 50.1 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,2KQ2V@206351|Neisseriales 206351|Neisseriales D Cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_167629_1 987059.RBXJA2T_12732 4.05e-74 243.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,1KIU8@119065|unclassified Burkholderiales 28216|Betaproteobacteria CP TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_1016992_1 713586.KB900536_gene2613 1.71e-39 148.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_1016992_2 342113.DM82_3231 1.08e-10 61.2 COG1595@1|root,COG1595@2|Bacteria,1RDDC@1224|Proteobacteria,2WEHU@28216|Betaproteobacteria,1KFW0@119060|Burkholderiaceae 28216|Betaproteobacteria K RNA polymerase sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_984225_1 1203606.HMPREF1526_02340 6.44e-15 72.4 COG1082@1|root,COG1082@2|Bacteria,1TS20@1239|Firmicutes,24E7U@186801|Clostridia,36NXH@31979|Clostridiaceae 186801|Clostridia G Xylose isomerase-like TIM barrel - - 5.3.99.11 ko:K06606 ko00562,ko01120,map00562,map01120 - R09952 RC01513 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_428353_1 987059.RBXJA2T_11917 1.69e-51 172.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2VJWH@28216|Betaproteobacteria 28216|Betaproteobacteria P 3'(2'),5'-bisphosphate nucleotidase cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_527049_1 1514668.JOOA01000002_gene961 8.98e-35 129.0 COG2189@1|root,COG2189@2|Bacteria,1UHUQ@1239|Firmicutes,25E35@186801|Clostridia,3WKD7@541000|Ruminococcaceae 186801|Clostridia L DNA methylase - - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_527049_2 323261.Noc_1343 1.01e-13 67.4 COG2119@1|root,COG2119@2|Bacteria,1N85A@1224|Proteobacteria,1SAAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_591646_1 1410622.JNKY01000019_gene1710 1.21e-52 185.0 COG2730@1|root,COG2730@2|Bacteria,1UYCF@1239|Firmicutes,24989@186801|Clostridia,27KIY@186928|unclassified Lachnospiraceae 186801|Clostridia G Cellulase (glycosyl hydrolase family 5) - - - - - - - - - - - - Cellulase,RicinB_lectin_2 k59_853694_1 522772.Dacet_0784 2.75e-69 233.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - - - - - - - - - - Paired_CXXCH_1 k59_951763_2 572544.Ilyop_0914 3.7e-48 156.0 COG0347@1|root,COG0347@2|Bacteria,37CG9@32066|Fusobacteria 32066|Fusobacteria K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_919463_1 749222.Nitsa_1019 1.97e-52 175.0 COG2908@1|root,COG2908@2|Bacteria,1Q1QY@1224|Proteobacteria,42STS@68525|delta/epsilon subdivisions,2YP6A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos k59_919463_2 387093.SUN_1501 1.22e-36 136.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,42MA2@68525|delta/epsilon subdivisions,2YNPU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S L,D-transpeptidase catalytic domain - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_1016994_1 1232443.BAIA02000075_gene462 7.8e-32 127.0 COG1879@1|root,COG1879@2|Bacteria,1VTWD@1239|Firmicutes,24YC2@186801|Clostridia,26A85@186813|unclassified Clostridiales 186801|Clostridia G helix_turn _helix lactose operon repressor - - - - - - - - - - - - LacI,Peripla_BP_4 k59_68990_1 187272.Mlg_0015 3.74e-104 313.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_885881_1 4006.Lus10013133 4.06e-18 86.7 COG2124@1|root,KOG0158@2759|Eukaryota,37HFX@33090|Viridiplantae,3GFPV@35493|Streptophyta,4JKW1@91835|fabids 35493|Streptophyta Q Cytochrome p450 - GO:0001763,GO:0006629,GO:0006720,GO:0006721,GO:0006810,GO:0007275,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009653,GO:0009889,GO:0009891,GO:0009893,GO:0009914,GO:0009926,GO:0009934,GO:0009962,GO:0009963,GO:0009987,GO:0010016,GO:0010223,GO:0010346,GO:0010817,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0019222,GO:0022603,GO:0032501,GO:0032502,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0048367,GO:0048509,GO:0048518,GO:0048646,GO:0048731,GO:0048856,GO:0050789,GO:0050793,GO:0051179,GO:0051234,GO:0060918,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:1901576,GO:1905393 - ko:K20771 - - - - ko00000,ko00199,ko01000 - - - p450 k59_885881_2 717606.PaecuDRAFT_1679 3.77e-93 315.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae 91061|Bacilli Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_494253_1 290400.Jann_3319 2.96e-30 117.0 COG0744@1|root,COG0744@2|Bacteria,1RDYG@1224|Proteobacteria,2U8WS@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Transglycosylase - - - - - - - - - - - - Transgly k59_951765_1 1168034.FH5T_13610 3.56e-59 196.0 COG1233@1|root,COG1233@2|Bacteria,4NF7K@976|Bacteroidetes,2FRUW@200643|Bacteroidia 976|Bacteroidetes Q Flavin containing amine oxidoreductase crtI - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_951765_2 36875.HQ29_08240 1.82e-06 50.4 COG3063@1|root,COG3063@2|Bacteria,4NTEN@976|Bacteroidetes,2FU86@200643|Bacteroidia,22YPZ@171551|Porphyromonadaceae 976|Bacteroidetes NU Type IV pilus biogenesis stability protein PilW - - - - - - - - - - - - TPR_8 k59_886288_1 1165841.SULAR_07725 6.29e-73 229.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,42MF9@68525|delta/epsilon subdivisions,2YN3Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0005488,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0663 Chorismate_synt k59_592186_1 485915.Dret_1016 1.48e-45 161.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42SM4@68525|delta/epsilon subdivisions,2WPVD@28221|Deltaproteobacteria,2MGHY@213115|Desulfovibrionales 28221|Deltaproteobacteria L Integrase core domain - - - - - - - - - - - - rve k59_625266_1 1049564.TevJSym_an00130 3.57e-59 191.0 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1J5RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600 - ko:K06203 - - - - ko00000 - - iJR904.b2413,iYL1228.KPN_02760 EI24 k59_396564_1 1122211.JMLW01000012_gene341 5.55e-73 234.0 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria,1XIV8@135619|Oceanospirillales 135619|Oceanospirillales F dihydroorotase - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_690670_1 1202532.FF52_14624 1.86e-14 72.4 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1HWYV@117743|Flavobacteriia,2NSFC@237|Flavobacterium 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_690670_2 504487.JCM19302_95 3.57e-15 78.2 COG0702@1|root,COG0702@2|Bacteria,4PKHQ@976|Bacteroidetes,1IJ9C@117743|Flavobacteriia 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_462387_1 1165841.SULAR_08142 5.91e-106 324.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,42MWP@68525|delta/epsilon subdivisions,2YNEC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Oxidoreductase - - 1.1.99.3 ko:K06151 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_462387_2 631362.Thi970DRAFT_01182 1.63e-15 73.9 2CJ51@1|root,321BV@2|Bacteria,1R3FV@1224|Proteobacteria,1T67C@1236|Gammaproteobacteria,1X0NH@135613|Chromatiales 135613|Chromatiales S Gluconate 2-dehydrogenase subunit 3 - - - - - - - - - - - - Gluconate_2-dh3 k59_919952_1 1123326.JFBL01000001_gene1279 4.15e-08 50.1 COG5554@1|root,COG5554@2|Bacteria,1Q3JU@1224|Proteobacteria,42XF5@68525|delta/epsilon subdivisions,2YQVJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q nitrogen fixation protein FixT - - - ko:K02593 - - - - ko00000 - - - NifT k59_919952_2 268739.Nmlp_3366 0.000565 47.0 COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23SN0@183963|Halobacteria 183963|Halobacteria C Succinate dehydrogenase fumarate reductase flavoprotein subunit sdhA2 - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_560322_1 1163617.SCD_n02290 4.3e-122 393.0 COG3437@1|root,COG3829@1|root,COG4191@1|root,COG5001@1|root,COG3437@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg k59_36528_1 1208321.D104_03635 8.64e-11 67.4 COG4932@1|root,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,1T2KS@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3 k59_331459_2 1123368.AUIS01000009_gene2460 5.81e-157 456.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,2NCDY@225057|Acidithiobacillales 225057|Acidithiobacillales S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_592194_1 933262.AXAM01000040_gene1232 3.52e-88 281.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_363812_1 1121374.KB891576_gene355 2.32e-06 54.7 COG1629@1|root,COG1629@2|Bacteria,1QTVF@1224|Proteobacteria,1T3JT@1236|Gammaproteobacteria 1236|Gammaproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_527620_1 572544.Ilyop_0363 6.48e-146 422.0 COG0342@1|root,COG0342@2|Bacteria,3791U@32066|Fusobacteria 32066|Fusobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_527620_2 572544.Ilyop_0364 8.41e-130 377.0 COG0341@1|root,COG0341@2|Bacteria,378NT@32066|Fusobacteria 32066|Fusobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_527620_4 1408439.JHXW01000003_gene1452 7.37e-105 314.0 COG1092@1|root,COG1092@2|Bacteria,378S7@32066|Fusobacteria 32066|Fusobacteria J Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_560331_1 742766.HMPREF9455_01482 5.8e-121 361.0 COG3637@1|root,COG3637@2|Bacteria,4NJFZ@976|Bacteroidetes,2G0CU@200643|Bacteroidia 976|Bacteroidetes M Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_265343_1 335543.Sfum_3683 2.78e-57 187.0 2C0QF@1|root,32R7C@2|Bacteria,1MYZK@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_168211_1 243090.RB6610 4.86e-47 172.0 28HY3@1|root,2Z83I@2|Bacteria,2IYQA@203682|Planctomycetes 203682|Planctomycetes S phosphoenolpyruvate carboxykinase (diphosphate) activity - - 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 - R00346 RC02741 ko00000,ko00001,ko01000 - - - - k59_200174_1 1517682.HW49_02095 7.27e-36 127.0 COG2954@1|root,COG2954@2|Bacteria,4NNGE@976|Bacteroidetes,2FNH1@200643|Bacteroidia,22XW0@171551|Porphyromonadaceae 976|Bacteroidetes S Adenylate cyclase cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_69500_2 1353529.M899_1071 4.29e-27 108.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,42MUA@68525|delta/epsilon subdivisions,2WJWH@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM Sodium calcium exchanger membrane region - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_527632_1 362418.IW19_21115 2.78e-77 244.0 COG5434@1|root,COG5434@2|Bacteria,4NEM8@976|Bacteroidetes,1I0ZR@117743|Flavobacteriia,2NURQ@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_462408_1 1232410.KI421420_gene3227 2.1e-64 218.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran,OEP k59_462408_2 765913.ThidrDRAFT_4466 1.43e-16 80.5 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1SYV1@1236|Gammaproteobacteria,1X2IS@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_625285_1 326298.Suden_1258 1.79e-104 314.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2YNK3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1883 Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit - - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_625285_2 326298.Suden_1256 1.66e-25 103.0 COG0845@1|root,COG0845@2|Bacteria,1QZ27@1224|Proteobacteria,43CEE@68525|delta/epsilon subdivisions,2YTBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - - k59_527635_1 43759.JNWK01000030_gene4377 3.02e-32 127.0 COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_102675_1 929558.SMGD1_2671 7.82e-37 137.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,42N7A@68525|delta/epsilon subdivisions,2YMRE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M lytic murein transglycosylase slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT k59_1017538_1 888055.HMPREF9015_00492 2.54e-11 64.7 COG0859@1|root,COG0859@2|Bacteria,378YY@32066|Fusobacteria 32066|Fusobacteria M heptosyltransferase - - - - - - - - - - - - Glyco_transf_9 k59_886315_1 1168034.FH5T_05020 1.19e-76 252.0 COG1520@1|root,COG1520@2|Bacteria,4NHQ3@976|Bacteroidetes,2FQ6V@200643|Bacteroidia 976|Bacteroidetes S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - DUF3352 k59_428806_1 572544.Ilyop_1878 1.05e-118 350.0 COG0697@1|root,COG0697@2|Bacteria,37B4T@32066|Fusobacteria 32066|Fusobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_69512_1 572544.Ilyop_0829 7.33e-19 83.6 COG0558@1|root,COG0558@2|Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_69512_2 1031288.AXAA01000030_gene244 4.09e-44 153.0 COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,36EQY@31979|Clostridiaceae 186801|Clostridia C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K07138 - - - - ko00000 - - - DUF362,Fer4,Fer4_4 k59_723298_1 1049564.TevJSym_ag00160 1.92e-95 291.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1J804@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_102679_1 1144325.PMI22_00608 1.77e-76 244.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214,DUF1254 k59_788684_2 1120951.AUBG01000014_gene3149 1.19e-15 75.9 COG0805@1|root,COG0805@2|Bacteria,4NEKM@976|Bacteroidetes,1HYNB@117743|Flavobacteriia 976|Bacteroidetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_200191_1 269799.Gmet_0790 5.82e-06 47.8 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42Q9U@68525|delta/epsilon subdivisions,2X5CC@28221|Deltaproteobacteria,43UFH@69541|Desulfuromonadales 28221|Deltaproteobacteria Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_36565_2 933262.AXAM01000005_gene2467 3.59e-64 200.0 COG1636@1|root,COG1636@2|Bacteria,1MUG5@1224|Proteobacteria,42M1E@68525|delta/epsilon subdivisions,2WMR5@28221|Deltaproteobacteria,2MJG7@213118|Desulfobacterales 28221|Deltaproteobacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queH - 1.17.99.6 ko:K09765 - - - - ko00000,ko01000,ko03016 - - - DUF208 k59_658519_1 1041147.AUFB01000032_gene5858 4.96e-19 86.7 COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2U0B6@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_658519_2 1122165.AUHS01000006_gene562 1.19e-14 73.6 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,1JGIP@118969|Legionellales 118969|Legionellales L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_690698_1 1249480.B649_09420 4.65e-119 351.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2YMPB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Glycerol-3-phosphate dehydrogenase glpC - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 k59_626030_2 1283300.ATXB01000001_gene2403 5.99e-122 363.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales 135618|Methylococcales S AAA-like domain - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 k59_561130_1 1168034.FH5T_11410 8.66e-125 367.0 COG1322@1|root,COG1322@2|Bacteria,4NE04@976|Bacteroidetes,2FMYJ@200643|Bacteroidia 976|Bacteroidetes S RmuC domain protein rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_789373_1 469381.Dpep_1028 1.31e-08 57.0 COG0330@1|root,COG0330@2|Bacteria,3TAJM@508458|Synergistetes 508458|Synergistetes O PFAM band 7 protein - - - - - - - - - - - - Band_7 k59_789373_2 572544.Ilyop_1279 1.73e-136 394.0 COG0275@1|root,COG0275@2|Bacteria,3789G@32066|Fusobacteria 32066|Fusobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_463203_2 631362.Thi970DRAFT_04275 7.89e-210 589.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWG6@135613|Chromatiales 135613|Chromatiales P Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_561135_1 1286632.P278_05350 1.01e-19 86.7 COG2755@1|root,COG2755@2|Bacteria,4P281@976|Bacteroidetes,1I7CB@117743|Flavobacteriia 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_985453_2 1120999.JONM01000017_gene60 6.85e-83 254.0 COG3608@1|root,COG3608@2|Bacteria,1QUH0@1224|Proteobacteria 1224|Proteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - - - - - - - - - - AstE_AspA k59_528433_1 1168034.FH5T_19530 9.1e-59 202.0 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,2FNBJ@200643|Bacteroidia 976|Bacteroidetes S Psort location OuterMembrane, score 9.49 - - - - - - - - - - - - TamB k59_528433_2 1168034.FH5T_19535 2.74e-14 71.6 COG1055@1|root,COG1055@2|Bacteria,4NGP4@976|Bacteroidetes,2FQ8M@200643|Bacteroidia 976|Bacteroidetes P Citrate transporter nhaD - - - - - - - - - - - CitMHS k59_920740_1 765911.Thivi_2101 8.79e-71 229.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1WWQB@135613|Chromatiales 135613|Chromatiales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_169070_3 198467.NP92_02805 1.22e-29 120.0 COG5525@1|root,COG5525@2|Bacteria,1TQBY@1239|Firmicutes,4HD7Q@91061|Bacilli 91061|Bacilli S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_659213_1 463191.SSEG_02541 9.64e-16 77.4 COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria 201174|Actinobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_920741_1 261292.Nit79A3_1075 4.46e-152 442.0 COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_886938_2 1121456.ATVA01000014_gene655 6.57e-39 141.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42MWF@68525|delta/epsilon subdivisions,2WKAQ@28221|Deltaproteobacteria,2M96F@213115|Desulfovibrionales 28221|Deltaproteobacteria M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_985465_1 1177154.Y5S_01704 1.32e-42 159.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_854936_1 1232410.KI421425_gene1550 3.5e-87 276.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_365208_1 292415.Tbd_1453 1.01e-77 247.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,2VJP0@28216|Betaproteobacteria,1KS9Q@119069|Hydrogenophilales 119069|Hydrogenophilales HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - RLAN k59_299210_1 391603.FBALC1_08848 4.65e-06 49.3 COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - HTH_18,TPR_2,TPR_8 k59_921221_1 929558.SMGD1_2868 1.9e-85 269.0 COG0683@1|root,COG0683@2|Bacteria,1Q7JN@1224|Proteobacteria,42NDA@68525|delta/epsilon subdivisions,2YN6T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E leucine binding - - - - - - - - - - - - - k59_70785_1 944547.ABLL_0050 1.14e-74 239.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,42P89@68525|delta/epsilon subdivisions,2YN9D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NifD NifK NifE NifN family - - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_169651_1 1219031.BBJR01000022_gene2540 6.4e-63 198.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2VQ16@28216|Betaproteobacteria,4ADKA@80864|Comamonadaceae 28216|Betaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_169651_2 1122604.JONR01000014_gene266 4.49e-05 45.1 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1X3MZ@135614|Xanthomonadales 135614|Xanthomonadales F Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate carB GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_365211_1 1168034.FH5T_07830 4.27e-118 370.0 COG1196@1|root,COG1196@2|Bacteria,4NF7P@976|Bacteroidetes,2FXCC@200643|Bacteroidia 976|Bacteroidetes D nuclear chromosome segregation - - - - - - - - - - - - DUF4175 k59_463806_1 498211.CJA_3511 4.94e-42 145.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,1FGJ2@10|Cellvibrio 1236|Gammaproteobacteria T Transcriptional regulatory protein, C terminal - - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_985990_1 1166130.H650_02705 2.12e-08 63.5 COG1835@1|root,COG1835@2|Bacteria 2|Bacteria I transferase activity, transferring acyl groups other than amino-acyl groups vanT - - - - - - - - - - - ABC2_membrane_5,Acyl_transf_3 k59_985990_2 1172190.M947_10425 2.18e-20 88.6 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions 1224|Proteobacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_495978_1 760568.Desku_2215 7.25e-40 148.0 COG1123@1|root,COG4172@2|Bacteria,1VRD0@1239|Firmicutes,25ECM@186801|Clostridia,267FF@186807|Peptococcaceae 186801|Clostridia P ATPases associated with a variety of cellular activities - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran,DUF3744 k59_659752_1 387093.SUN_0173 1.49e-69 220.0 COG3705@1|root,COG3705@2|Bacteria,1QV6Q@1224|Proteobacteria,43BNS@68525|delta/epsilon subdivisions,2YT9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - - - - - - - - - - tRNA-synt_His k59_1018903_1 411479.BACUNI_00268 7.81e-112 345.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FNZH@200643|Bacteroidia,4AKR8@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family bglB - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_822854_1 472759.Nhal_0548 4.79e-43 156.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_691953_1 448385.sce0227 3.03e-43 160.0 COG1944@1|root,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,42N4B@68525|delta/epsilon subdivisions,2WJ34@28221|Deltaproteobacteria,2YU6P@29|Myxococcales 28221|Deltaproteobacteria S YcaO cyclodehydratase, ATP-ad Mg2+-binding - - - ko:K09136 - - - - ko00000,ko03009 - - - YcaO k59_332796_1 742725.HMPREF9450_01257 4.34e-56 181.0 COG2188@1|root,COG2188@2|Bacteria,4NFVY@976|Bacteroidetes,2FXB6@200643|Bacteroidia 976|Bacteroidetes K UTRA - - - ko:K03710,ko:K10711 - - - - ko00000,ko03000 - - - GntR,UTRA k59_593425_1 1210884.HG799465_gene11977 5.51e-14 72.0 COG2304@1|root,COG2304@2|Bacteria,2IYBK@203682|Planctomycetes 203682|Planctomycetes K von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A k59_201430_2 929558.SMGD1_2234 3.76e-25 100.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2YT4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Hydrogenase maturation protease hybD - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_756716_1 1168034.FH5T_08585 1.4e-71 219.0 COG1225@1|root,COG1225@2|Bacteria,4NQCB@976|Bacteroidetes,2FXA6@200643|Bacteroidia 976|Bacteroidetes O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_103999_1 1179778.PMM47T1_08496 3.16e-21 95.5 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,1RQRT@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Xanthine and CO dehydrogenases maturation factor XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_103999_2 1380390.JIAT01000017_gene5363 5.86e-19 88.2 COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria,4CQMI@84995|Rubrobacteria 84995|Rubrobacteria S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - 1.1.1.328,2.7.7.76 ko:K07141,ko:K19190 ko00760,ko00790,ko01120,map00760,map00790,map01120 - R10131,R10132,R11582 RC03053 ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_429843_1 1449351.RISW2_11095 2.9e-72 228.0 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,2TU96@28211|Alphaproteobacteria,4KM6K@93682|Roseivivax 28211|Alphaproteobacteria P Helix-turn-helix domain - - - - - - - - - - - - HTH_17,PBP_like k59_986015_1 1168034.FH5T_09330 5.17e-166 484.0 COG0557@1|root,COG0557@2|Bacteria,4NE7T@976|Bacteroidetes,2FMM6@200643|Bacteroidia 976|Bacteroidetes J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573,ko:K12585 ko03018,map03018 M00391 - - ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_659779_1 945543.VIBR0546_01476 2.91e-15 79.3 2DPCB@1|root,331HJ@2|Bacteria,1NED4@1224|Proteobacteria,1SGZF@1236|Gammaproteobacteria,1XYAZ@135623|Vibrionales 135623|Vibrionales S Putative phage abortive infection protein - - - - - - - - - - - - putAbiC k59_463834_1 1244528.CFT03427_1012 2.84e-20 85.9 COG1917@1|root,COG1917@2|Bacteria,1QTHP@1224|Proteobacteria,42VCM@68525|delta/epsilon subdivisions,2YQD1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S conserved protein, contains double-stranded beta-helix domain - - - - - - - - - - - - AraC_binding,Cupin_2 k59_136835_1 572480.Arnit_1378 1.32e-23 94.7 COG1433@1|root,COG1433@2|Bacteria,1P8Y4@1224|Proteobacteria,42VVM@68525|delta/epsilon subdivisions,2YQI1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - - k59_136835_2 1122236.KB905146_gene1876 9.6e-08 53.1 COG0748@1|root,COG0748@2|Bacteria,1REH2@1224|Proteobacteria 1224|Proteobacteria P Heme iron utilization protein hutZ - - ko:K07226 - - - - ko00000 - - - Putative_PNPOx k59_561628_1 1415780.JPOG01000001_gene2274 4.28e-19 80.1 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1X6XT@135614|Xanthomonadales 135614|Xanthomonadales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_561628_2 720555.BATR1942_02695 3.96e-08 55.8 COG1232@1|root,COG1232@2|Bacteria,1TQ6W@1239|Firmicutes,4HAUG@91061|Bacilli,1ZANK@1386|Bacillus 91061|Bacilli H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS09325 Amino_oxidase k59_332817_1 1165841.SULAR_10264 7.44e-57 187.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,42MYW@68525|delta/epsilon subdivisions,2YN5Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_332817_2 1111728.ATYS01000018_gene3293 4.02e-05 45.8 COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,1RN6Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) ycgM - - - - - - - - - - - FAA_hydrolase k59_201445_1 582744.Msip34_1305 2.03e-63 202.0 COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,2VQHY@28216|Betaproteobacteria,2KKZM@206350|Nitrosomonadales 206350|Nitrosomonadales S Phospholipid methyltransferase - - - - - - - - - - - - DUF1295 k59_429851_1 472759.Nhal_3454 1.05e-41 145.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales 135613|Chromatiales O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_463843_1 1109445.AGSX01000117_gene3359 3.7e-49 172.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1Z0NY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria FP Belongs to the GppA Ppx family gppA GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006797,GO:0006798,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008894,GO:0009056,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0042594,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:1901360,GO:1901575 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463,iECIAI39_1322.ECIAI39_2643 HD,Ppx-GppA k59_299257_1 479432.Sros_3166 8.17e-33 130.0 COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria,4EPXP@85012|Streptosporangiales 201174|Actinobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_3552_2 526218.Sterm_1018 6.51e-260 723.0 COG1492@1|root,COG1492@2|Bacteria,3785G@32066|Fusobacteria 32066|Fusobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_3552_3 523794.Lebu_0042 3.92e-128 375.0 COG1270@1|root,COG1270@2|Bacteria,3794J@32066|Fusobacteria 32066|Fusobacteria H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_3552_4 526218.Sterm_1020 2.57e-52 175.0 COG0079@1|root,COG0079@2|Bacteria,378HR@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_332824_1 1101195.Meth11DRAFT_1813 2.27e-06 57.8 COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,2KNF2@206350|Nitrosomonadales 206350|Nitrosomonadales Q TIGRFAM outer membrane adhesin like proteiin - - - - - - - - - - - - Calx-beta,HemolysinCabind k59_822885_1 765911.Thivi_2806 5.8e-43 159.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales 135613|Chromatiales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_887386_1 1392488.JHZY01000004_gene3491 6.44e-15 78.2 COG3663@1|root,COG3663@2|Bacteria,4NEZ4@976|Bacteroidetes,1HY0W@117743|Flavobacteriia,2XIKB@283735|Leeuwenhoekiella 976|Bacteroidetes L G T U mismatch-specific DNA glycosylase - - - - - - - - - - - - - k59_397708_4 765912.Thimo_3446 2.01e-44 148.0 COG5642@1|root,COG5642@2|Bacteria,1N1FN@1224|Proteobacteria,1SD5Z@1236|Gammaproteobacteria,1WYVG@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384 k59_397708_8 1144319.PMI16_04513 4.37e-128 436.0 COG3209@1|root,COG3209@2|Bacteria,1R1SB@1224|Proteobacteria,2W3D6@28216|Betaproteobacteria 2|Bacteria M Salmonella virulence plasmid 65kDa B protein - - - - - - - - - - - - CHB_HEX_C_1,CotH,Flg_new,Fn3_assoc,LRR_5,LTD,Peptidase_S9,SpvB,TcdB_toxin_midN,VCBS k59_397708_10 1333507.AUTQ01000019_gene1878 2.85e-05 49.7 COG3149@1|root,COG3149@2|Bacteria,1N8VZ@1224|Proteobacteria,1S32Y@1236|Gammaproteobacteria,2Q29J@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins yghD - - ko:K02462 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSM k59_397708_11 2340.JV46_18960 2.2e-22 106.0 COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,1JB3D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins gspL GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_397708_12 1288826.MSNKSG1_05526 1.13e-47 169.0 COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,1S5US@1236|Gammaproteobacteria,46CQU@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG3156 Type II secretory pathway, component PulK xcpX - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_397708_13 1323663.AROI01000016_gene419 2.15e-19 89.4 COG4795@1|root,COG4795@2|Bacteria 2|Bacteria U General secretion pathway protein gspJ - - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSJ k59_397708_14 998674.ATTE01000001_gene515 8.83e-16 75.5 COG2165@1|root,COG2165@2|Bacteria,1N737@1224|Proteobacteria,1SC8X@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU General secretion pathway protein I gspI GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02458 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSI k59_397708_16 396588.Tgr7_0231 1.02e-60 191.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales 135613|Chromatiales U general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_397708_18 391615.ABSJ01000050_gene1178 5.62e-164 493.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J7Q2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Bacterial type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_397708_19 857087.Metme_0903 5.94e-217 615.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XE8Y@135618|Methylococcales 135618|Methylococcales NU PFAM Type II secretion system protein E - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_397708_20 1123257.AUFV01000008_gene555 5.86e-141 414.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1X3ZU@135614|Xanthomonadales 135614|Xanthomonadales U General secretion pathway protein xcsF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_986035_1 1249480.B649_10390 1.24e-64 202.0 2AHPN@1|root,3181V@2|Bacteria,1PZNU@1224|Proteobacteria,42QWU@68525|delta/epsilon subdivisions,2YMYS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3972) - - - - - - - - - - - - DUF3972 k59_986035_2 326298.Suden_1863 1.51e-25 98.6 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2YNW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_169685_1 1321779.HMPREF1984_00738 1.87e-175 504.0 COG0019@1|root,COG0019@2|Bacteria,378BJ@32066|Fusobacteria 32066|Fusobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_169685_2 441620.Mpop_4198 2.76e-35 137.0 COG1879@1|root,COG1879@2|Bacteria,1MWGU@1224|Proteobacteria,2U2E3@28211|Alphaproteobacteria,1JZ7X@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Periplasmic binding protein-like domain mocB1 - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_593465_1 1121405.dsmv_0272 8.04e-107 333.0 COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria,2MJER@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01990,ko:K13926 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3,ABC_tran k59_397712_1 713587.THITH_01120 9.49e-08 51.6 2EKK5@1|root,33EA0@2|Bacteria,1NI6Y@1224|Proteobacteria,1SGCX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative addiction module component - - - - - - - - - - - - Unstab_antitox k59_397712_2 517417.Cpar_0534 1.81e-37 129.0 COG3668@1|root,COG3668@2|Bacteria,1FFP3@1090|Chlorobi 1090|Chlorobi S PFAM plasmid stabilization system - - - - - - - - - - - - ParE_toxin k59_986043_2 1249627.D779_3355 6.25e-64 198.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1WWE7@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_822900_1 700598.Niako_1837 9.53e-36 134.0 COG1231@1|root,COG1231@2|Bacteria,4PMAQ@976|Bacteroidetes 976|Bacteroidetes E Protein of unknown function (DUF1593) - - - - - - - - - - - - DUF1593 k59_822900_2 1231241.Mc24_06683 2.58e-22 95.1 COG1879@1|root,COG1879@2|Bacteria,2GBXD@200918|Thermotogae 200918|Thermotogae G PFAM periplasmic binding protein LacI transcriptional regulator - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_429868_1 929558.SMGD1_0636 9.43e-194 567.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2YMGZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_365274_1 1122128.AUEE01000012_gene64 6.34e-17 75.9 COG4095@1|root,COG4095@2|Bacteria,1VF4D@1239|Firmicutes,4I0UK@91061|Bacilli 91061|Bacilli S PQ loop repeat - - - ko:K15383 - - - - ko00000,ko02000 9.A.58.2 - - PQ-loop k59_365274_2 696747.NIES39_A08050 4.21e-13 66.2 COG4095@1|root,COG4095@2|Bacteria,1G9AI@1117|Cyanobacteria,1HCTA@1150|Oscillatoriales 1117|Cyanobacteria S PQ loop repeat - - - ko:K15383 - - - - ko00000,ko02000 9.A.58.2 - - MtN3_slv,PQ-loop k59_365274_3 397290.C810_00932 3.26e-27 102.0 COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,27S3G@186928|unclassified Lachnospiraceae 186801|Clostridia O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_365274_4 1227268.HMPREF1552_02074 2.15e-273 760.0 COG0459@1|root,COG0459@2|Bacteria,378J4@32066|Fusobacteria 32066|Fusobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_71356_1 999541.bgla_1g33210 3.6e-180 509.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,1K1Z0@119060|Burkholderiaceae 28216|Betaproteobacteria G fructose-bisphosphate aldolase, class II, Calvin cycle subtype fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_823292_1 1280685.AUKC01000003_gene2869 3.8e-41 148.0 COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,4BWF6@830|Butyrivibrio 186801|Clostridia O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_823292_2 572544.Ilyop_0575 7.43e-109 317.0 COG0740@1|root,COG0740@2|Bacteria,379EV@32066|Fusobacteria 32066|Fusobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_823292_3 572544.Ilyop_0574 1.05e-96 296.0 COG0544@1|root,COG0544@2|Bacteria,3783R@32066|Fusobacteria 32066|Fusobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_398132_1 288000.BBta_5329 2e-30 124.0 COG0784@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JR0R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Response regulator receiver - - - - - - - - - - - - CHASE3,HATPase_c,HisKA,MASE4,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_365747_1 929558.SMGD1_1084 2.65e-38 140.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2YMCW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iIT341.HP0476 tRNA-synt_1c k59_365747_2 929558.SMGD1_1003 4.25e-13 68.9 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2YMJJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C malic enzyme mez - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_430241_1 1168034.FH5T_10715 6.87e-83 265.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,2FS4M@200643|Bacteroidia 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 k59_1019363_1 1211114.ALIP01000115_gene1475 9.77e-77 246.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1X3W8@135614|Xanthomonadales 135614|Xanthomonadales IQ Activates fatty acids by binding to coenzyme A rpfB - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_398136_1 391613.RTM1035_08019 3.15e-15 75.9 2DG8R@1|root,2ZUYV@2|Bacteria,1RG4Q@1224|Proteobacteria,2U6V3@28211|Alphaproteobacteria,46PSZ@74030|Roseovarius 28211|Alphaproteobacteria H Sulfotransferase family - - 2.8.2.2 ko:K01015 ko00140,map00140 - R00629,R03405,R08977,R08978 RC00007,RC00231,RC00341 ko00000,ko00001,ko01000 - - - Sulfotransfer_1 k59_398136_2 1265313.HRUBRA_01486 1.2e-39 143.0 COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,1SKFB@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Mitochondrial fission ELM1 - - - - - - - - - - - - Mito_fiss_Elm1 k59_921768_1 1452718.JBOY01000001_gene563 1.75e-70 227.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria 1224|Proteobacteria H aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_365754_1 1168034.FH5T_02905 4.12e-98 302.0 COG1524@1|root,COG1524@2|Bacteria,4NE94@976|Bacteroidetes,2FMQC@200643|Bacteroidia 976|Bacteroidetes P type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_398139_3 1049564.TevJSym_aw00380 5.05e-09 55.8 2ER47@1|root,33IPS@2|Bacteria,1NHAY@1224|Proteobacteria 1224|Proteobacteria S chemotaxis protein - - - - - - - - - - - - DUF2802 k59_823300_1 34506.g5830 4.39e-55 194.0 COG0499@1|root,COG2008@1|root,KOG1368@2759|Eukaryota,KOG1370@2759|Eukaryota,38CN8@33154|Opisthokonta,3BD4V@33208|Metazoa,3CREX@33213|Bilateria,40AM4@6231|Nematoda,1KTZV@119089|Chromadorea,40Z82@6236|Rhabditida 33208|Metazoa H S-adenosyl-L-homocysteine hydrolase, NAD binding domain - - - - - - - - - - - - AdoHcyase,AdoHcyase_NAD k59_855950_1 1249975.JQLP01000005_gene685 6.25e-141 423.0 COG2189@1|root,COG2189@2|Bacteria,4NFKE@976|Bacteroidetes,1I3ME@117743|Flavobacteriia 976|Bacteroidetes L DNA methylase - - 2.1.1.72 ko:K00571,ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_170096_1 1265313.HRUBRA_01505 0.000223 47.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1J4FT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_464287_1 1406840.Q763_10380 6.24e-73 232.0 COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,1HYIB@117743|Flavobacteriia,2NTIR@237|Flavobacterium 976|Bacteroidetes E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_266951_1 398767.Glov_1197 1.53e-14 72.0 COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria,43VST@69541|Desulfuromonadales 28221|Deltaproteobacteria C Rieske [2Fe-2S] domain cbcO - - - - - - - - - - iAF987.Gmet_0538 Rieske k59_104524_1 566466.NOR53_592 3.81e-71 234.0 COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria 1236|Gammaproteobacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 k59_430258_1 1328313.DS2_14429 2.11e-18 79.0 COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,1S8R5@1236|Gammaproteobacteria,467S6@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 13 family - - - - - - - - - - - - AMPK1_CBM,CBM_48 k59_201936_1 645991.Sgly_3047 7.14e-19 80.5 2E5UQ@1|root,330IY@2|Bacteria,1VI50@1239|Firmicutes,24QVH@186801|Clostridia,265VS@186807|Peptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_201936_2 926692.AZYG01000086_gene728 1.09e-07 51.6 2CH3Z@1|root,32RP9@2|Bacteria,1V9MP@1239|Firmicutes,24K61@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF2721) - - - - - - - - - - - - DUF2721 k59_627086_1 1121920.AUAU01000006_gene287 1.27e-25 104.0 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination - - - - - - - - - - - - EamA k59_627086_2 550540.Fbal_1923 1.11e-50 165.0 2C7KN@1|root,30RKS@2|Bacteria,1N486@1224|Proteobacteria,1T684@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_137421_1 631362.Thi970DRAFT_02329 1.53e-79 253.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVW7@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_593977_1 1168034.FH5T_11390 1.67e-143 416.0 COG0450@1|root,COG0450@2|Bacteria,4PMJ6@976|Bacteroidetes,2G0D3@200643|Bacteroidia 976|Bacteroidetes O Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,DUF4369,Thioredoxin_8 k59_593977_2 1004149.AFOE01000049_gene1917 8.78e-24 97.4 COG2908@1|root,COG2908@2|Bacteria,4NEF1@976|Bacteroidetes,1HWZZ@117743|Flavobacteriia 976|Bacteroidetes S UDP-2,3-diacylglucosamine hydrolase lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_887852_1 1458357.BG58_13300 2.47e-99 302.0 COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,2VYFJ@28216|Betaproteobacteria,1K4C2@119060|Burkholderiaceae 28216|Betaproteobacteria C Radical SAM superfamily - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_921784_1 572544.Ilyop_0034 2.88e-220 613.0 COG0126@1|root,COG0126@2|Bacteria,378CE@32066|Fusobacteria 32066|Fusobacteria F Psort location Cytoplasmic, score 9.97 pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_266953_1 929558.SMGD1_1526 2.22e-51 164.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2YP80@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_266953_2 563040.Saut_1947 1.39e-85 253.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,42SD5@68525|delta/epsilon subdivisions,2YP70@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_38208_1 1537917.JU82_01410 3.6e-160 457.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2YN1A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase aspB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_38208_2 1537917.JU82_01430 8.07e-28 102.0 2AK1D@1|root,31AQZ@2|Bacteria,1Q5ZH@1224|Proteobacteria,42V6N@68525|delta/epsilon subdivisions,2YQ6B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_790183_1 1121937.AUHJ01000002_gene3618 6.07e-81 260.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,4668R@72275|Alteromonadaceae 1236|Gammaproteobacteria G PQQ enzyme repeat - - - - - - - - - - - - PQQ,PQQ_2 k59_333389_1 203122.Sde_3837 1.7e-10 62.4 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,46476@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008412,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - iZ_1308.Z5639 UbiA k59_333389_2 477228.YO5_17005 3.14e-08 57.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1Z1VB@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Phosphoribosyl transferase domain gntX GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - Pribosyltran k59_3866_1 1227349.C170_25547 3.54e-36 135.0 COG0477@1|root,COG2814@2|Bacteria,1TQXU@1239|Firmicutes,4HB56@91061|Bacilli,26QU7@186822|Paenibacillaceae 1239|Firmicutes EGP Arabinose efflux permease - - - - - - - - - - - - MFS_1 k59_398164_1 768671.ThimaDRAFT_3685 6.76e-25 107.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,1RQ9W@1236|Gammaproteobacteria,1WZG5@135613|Chromatiales 135613|Chromatiales L Integrase catalytic - - - - - - - - - - - - HTH_23,rve k59_201937_1 929558.SMGD1_0452 1.65e-183 519.0 COG1636@1|root,COG1636@2|Bacteria,1MUG5@1224|Proteobacteria,42M1E@68525|delta/epsilon subdivisions,2YN69@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queH - 1.17.99.6 ko:K09765 - - - - ko00000,ko01000,ko03016 - - - DUF208 k59_201937_2 1537917.JU82_05770 2.16e-105 305.0 COG0652@1|root,COG0652@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2YNZU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_3867_1 1034943.BN1094_00648 5.05e-27 105.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1SC4Z@1236|Gammaproteobacteria,1JEEB@118969|Legionellales 118969|Legionellales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_593991_1 765912.Thimo_0415 4.67e-59 194.0 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,1RNUY@1236|Gammaproteobacteria,1WW69@135613|Chromatiales 135613|Chromatiales G Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_593993_1 590998.Celf_2343 1.4e-65 218.0 COG1506@1|root,COG1506@2|Bacteria,2I2K7@201174|Actinobacteria,4F0GK@85016|Cellulomonadaceae 201174|Actinobacteria E peptidase - - - - - - - - - - - - BAAT_C,Peptidase_S9 k59_201949_1 391595.RLO149_c037000 1.89e-69 228.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_692479_1 247490.KSU1_C0822 8.27e-24 98.6 COG3959@1|root,COG3959@2|Bacteria,2IXRU@203682|Planctomycetes 203682|Planctomycetes G 1-deoxy-D-xylulose-5-phosphate synthase - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_692479_2 891968.Anamo_1572 9.98e-32 128.0 COG2199@1|root,COG2202@1|root,COG2984@1|root,COG2202@2|Bacteria,COG2984@2|Bacteria,COG3706@2|Bacteria,3TBCU@508458|Synergistetes 508458|Synergistetes T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,PAS_3,PAS_9 k59_137452_1 313596.RB2501_12202 1.2e-16 80.5 2E3AK@1|root,320TI@2|Bacteria,4NRX2@976|Bacteroidetes,1I3SJ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_692482_1 929558.SMGD1_0130 8.08e-76 240.0 COG4773@1|root,COG4773@2|Bacteria,1QZ1U@1224|Proteobacteria,42PHE@68525|delta/epsilon subdivisions,2YN5J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD k59_692482_2 883126.HMPREF9710_02226 9.88e-17 80.9 COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,2VMCH@28216|Betaproteobacteria,474U1@75682|Oxalobacteraceae 28216|Betaproteobacteria H TOBE domain modE - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1,TOBE k59_724957_2 412965.COSY_0866 7.06e-05 51.2 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,1J4YY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_104570_1 318161.Sden_2282 9.44e-44 152.0 COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,1RQUQ@1236|Gammaproteobacteria,2QBUG@267890|Shewanellaceae 1236|Gammaproteobacteria S Belongs to the UPF0502 family yceH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09915 - - - - ko00000 - - - DUF480 k59_986606_1 1168034.FH5T_05740 8.19e-94 302.0 COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,2FN0V@200643|Bacteroidia 976|Bacteroidetes G Glycoside hydrolase family 3 - - - - - - - - - - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C k59_430303_1 1122933.JNIY01000003_gene96 2.86e-62 203.0 COG2265@1|root,COG2265@2|Bacteria,2GP90@201174|Actinobacteria,4F24B@85016|Cellulomonadaceae 201174|Actinobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumB - 2.1.1.189 ko:K03212 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr k59_1019419_1 10724.Q38143_BPSPP 3.89e-32 120.0 4QBHS@10239|Viruses,4QUVV@35237|dsDNA viruses no RNA stage,4QPT9@28883|Caudovirales,4QKSP@10699|Siphoviridae 10699|Siphoviridae S DNA metabolic process - - - - - - - - - - - - - k59_627140_2 178901.AmDm5_1608 5.05e-07 53.5 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,2JPZV@204441|Rhodospirillales 204441|Rhodospirillales T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_529642_1 1168034.FH5T_01395 5.28e-134 392.0 COG0668@1|root,COG0668@2|Bacteria,4NE4R@976|Bacteroidetes,2FN78@200643|Bacteroidia 976|Bacteroidetes M COG0668 Small-conductance mechanosensitive channel mscS - - ko:K16053 - - - - ko00000,ko02000 1.A.23.4.5 - - MS_channel k59_529642_2 1168034.FH5T_01390 1.79e-98 287.0 COG1522@1|root,COG1522@2|Bacteria,4NMEN@976|Bacteroidetes,2FMP2@200643|Bacteroidia 976|Bacteroidetes K Transcriptional regulator, AsnC Family asnC - - ko:K03718 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_594014_1 1286171.EAL2_808p05780 1.26e-12 62.8 COG1143@1|root,COG1143@2|Bacteria,1UMZ8@1239|Firmicutes,25GSU@186801|Clostridia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 k59_594014_2 795359.TOPB45_0541 8.88e-45 149.0 COG2033@1|root,COG2033@2|Bacteria,2GHU1@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Desulfoferrodoxin, N-terminal domain - - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrod_N,Desulfoferrodox k59_594014_4 572544.Ilyop_1458 6.34e-64 203.0 COG0730@1|root,COG0730@2|Bacteria,37869@32066|Fusobacteria 32066|Fusobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_201976_2 1500894.JQNN01000001_gene2756 5.54e-17 81.3 COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,2VWI6@28216|Betaproteobacteria,475GP@75682|Oxalobacteraceae 28216|Betaproteobacteria G Cyclomaltodextrinase, N-terminal - - - - - - - - - - - - Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N k59_562172_2 1384054.N790_07735 1.02e-24 98.6 2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1X82G@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4426) - - - - - - - - - - - - DUF4426 k59_953745_1 1238182.C882_1324 1.19e-40 141.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,2JWES@204441|Rhodospirillales 204441|Rhodospirillales L leucine-zipper of insertion element IS481 - - - - - - - - - - - - HTH_32 k59_953745_2 1280948.HY36_17905 2.63e-43 144.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2963 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_790211_1 765910.MARPU_04535 1.3e-72 236.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1WWH7@135613|Chromatiales 135613|Chromatiales HJ ATP-grasp - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,RimK k59_365831_1 1301098.PKB_1073 1.88e-59 208.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_562174_1 1123401.JHYQ01000027_gene3133 1.31e-103 324.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,45ZRI@72273|Thiotrichales 72273|Thiotrichales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_464351_1 1391646.AVSU01000100_gene3406 1.04e-25 107.0 COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,247UX@186801|Clostridia,25QFG@186804|Peptostreptococcaceae 186801|Clostridia C Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF k59_529649_1 1464048.JNZS01000005_gene5513 4.03e-08 55.1 COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4DATY@85008|Micromonosporales 201174|Actinobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_529649_2 1294142.CINTURNW_0557 1.45e-172 501.0 COG2195@1|root,COG2195@2|Bacteria,1TQBS@1239|Firmicutes,24860@186801|Clostridia,36DNZ@31979|Clostridiaceae 186801|Clostridia E aminoacyl-histidine dipeptidase pepD - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_529649_3 642492.Clole_0628 3.1e-38 140.0 COG2206@1|root,COG2206@2|Bacteria,1V1J0@1239|Firmicutes,24FUR@186801|Clostridia 186801|Clostridia T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - HD,HD_5 k59_594042_1 749222.Nitsa_0208 7.5e-66 209.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,42M1Y@68525|delta/epsilon subdivisions,2YMJA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hydrolase aguB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_72097_2 1286106.MPL1_02718 1.64e-14 73.9 COG0746@1|root,COG1763@1|root,COG0746@2|Bacteria,COG1763@2|Bacteria,1RH3M@1224|Proteobacteria,1RN20@1236|Gammaproteobacteria,462JK@72273|Thiotrichales 72273|Thiotrichales H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K13818 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - MobB,NTP_transf_3 k59_823818_2 1168034.FH5T_00235 1.21e-225 629.0 COG0176@1|root,COG0176@2|Bacteria,4P1X0@976|Bacteroidetes,2FX3H@200643|Bacteroidia 976|Bacteroidetes G Transaldolase/Fructose-6-phosphate aldolase - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_823818_3 1168289.AJKI01000017_gene1968 5.46e-53 179.0 COG0508@1|root,COG0508@2|Bacteria,4NF33@976|Bacteroidetes,2FRN0@200643|Bacteroidia,3XIRF@558415|Marinilabiliaceae 976|Bacteroidetes C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_235403_1 1249627.D779_3352 2.24e-86 285.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_594691_1 748727.CLJU_c42180 4.26e-19 86.3 COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,36E25@31979|Clostridiaceae 186801|Clostridia S 2-nitropropane dioxygenase fabK - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - iHN637.CLJU_RS20775 NMO k59_594691_2 572544.Ilyop_1510 1.71e-151 433.0 COG0331@1|root,COG0331@2|Bacteria,378Z9@32066|Fusobacteria 32066|Fusobacteria I Psort location Cytoplasmic, score fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_594691_3 66377.JOBH01000002_gene1022 2.92e-24 101.0 COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - 1.1.1.53 ko:K00038 ko00140,ko01100,map00140,map01100 - R04831,R04834,R04844,R04847 RC00139,RC01219,RC01220 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_692990_1 314285.KT71_12795 1.19e-91 282.0 COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1J8ZH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_464760_1 572480.Arnit_2467 5.61e-41 137.0 COG1917@1|root,COG1917@2|Bacteria,1RDGQ@1224|Proteobacteria,42U6Z@68525|delta/epsilon subdivisions,2YRZY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant ectC - 4.2.1.108 ko:K06720 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06979 RC01729 ko00000,ko00001,ko00002,ko01000 - - - Ectoine_synth k59_464760_2 944547.ABLL_2143 3.36e-135 395.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42N1V@68525|delta/epsilon subdivisions 1224|Proteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family ectB - 2.6.1.19,2.6.1.22,2.6.1.76 ko:K00836,ko:K07250 ko00250,ko00260,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00280,map00410,map00640,map00650,map01100,map01120,map01210,map01230 M00027,M00033 R00908,R01648,R04188,R06977 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1019877_1 8479.XP_005281549.1 0.000395 50.4 COG2801@1|root,KOG1721@1|root,KOG0017@2759|Eukaryota,KOG1721@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,48B0V@7711|Chordata,499U9@7742|Vertebrata,4CK8P@8459|Testudines 33208|Metazoa L K02A2.6-like - - - - - - - - - - - - RVT_1,SCAN,rve,zf-CCHC,zf-H2C2 k59_562696_1 215803.DB30_5300 1.69e-49 177.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,42PPZ@68525|delta/epsilon subdivisions,2WWBR@28221|Deltaproteobacteria,2YXC6@29|Myxococcales 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_594696_1 1168034.FH5T_03010 8.61e-60 203.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,2FQ8Z@200643|Bacteroidia 976|Bacteroidetes N ABC-type uncharacterized transport system gldG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_594696_2 945543.VIBR0546_19854 8.36e-05 47.8 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1XSUV@135623|Vibrionales 135623|Vibrionales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_334092_1 522373.Smlt2043 3.27e-75 241.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1X3UC@135614|Xanthomonadales 135614|Xanthomonadales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_987230_1 1392489.JPOL01000002_gene2047 1.44e-28 111.0 COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,1HXC4@117743|Flavobacteriia,2XIDC@283735|Leeuwenhoekiella 976|Bacteroidetes E Asparaginase ybiK - 3.4.19.5 ko:K13051 - - - - ko00000,ko01000,ko01002 - - - Asparaginase_2 k59_987230_2 1123261.AXDW01000002_gene1524 3.64e-30 114.0 COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,1RMVD@1236|Gammaproteobacteria,1X39H@135614|Xanthomonadales 135614|Xanthomonadales G Inositol monophosphatase family - - 3.1.3.15 ko:K05602 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_692998_1 688269.Theth_0233 1.63e-69 218.0 COG1933@1|root,COG1933@2|Bacteria,2GDRW@200918|Thermotogae 200918|Thermotogae L exodeoxyribonuclease I activity - - - - - - - - - - - - - k59_202606_1 1121405.dsmv_2651 2.14e-173 501.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_627757_1 713587.THITH_02750 8.71e-134 395.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales 135613|Chromatiales J TIGRFAM ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_366421_1 573061.Clocel_3942 3.3e-51 182.0 COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae 186801|Clostridia Q Beta-ketoacyl synthase - - - - - - - - - - - - Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt k59_202608_2 1165841.SULAR_07785 7.38e-22 90.1 2AJIW@1|root,31A5Q@2|Bacteria,1Q4ZS@1224|Proteobacteria,4308B@68525|delta/epsilon subdivisions,2YRXE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Phosphate-starvation-inducible E - - - - - - - - - - - - PsiE k59_202608_3 709032.Sulku_1130 1.64e-09 57.4 COG0352@1|root,COG0352@2|Bacteria,1Q57E@1224|Proteobacteria,42T8S@68525|delta/epsilon subdivisions,2YPQM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Thiamine monophosphate synthase thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_823833_1 1168034.FH5T_09760 1.23e-121 369.0 COG2010@1|root,COG2993@1|root,COG3278@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO k59_1019892_1 1168034.FH5T_20135 3.56e-89 290.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,2FQUJ@200643|Bacteroidia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_398760_1 1121015.N789_01620 7.36e-29 106.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,1X6XE@135614|Xanthomonadales 135614|Xanthomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_170668_1 1121438.JNJA01000016_gene1516 7.47e-59 196.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42NP2@68525|delta/epsilon subdivisions,2WIY2@28221|Deltaproteobacteria,2M8N5@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_300234_1 472759.Nhal_1512 1.13e-107 321.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1WWUS@135613|Chromatiales 135613|Chromatiales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_954226_1 929558.SMGD1_1549 5.58e-29 119.0 COG4773@1|root,COG4773@2|Bacteria,1PP2I@1224|Proteobacteria,42WFP@68525|delta/epsilon subdivisions,2YQM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD k59_105233_1 1168034.FH5T_13660 6.31e-104 318.0 COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,2FMK5@200643|Bacteroidia 976|Bacteroidetes T Tetratricopeptide repeat protein batD - - - - - - - - - - - BatD,TPR_2 k59_1019900_1 1415778.JQMM01000001_gene2088 1.71e-47 169.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,1JBW8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_105235_1 1168034.FH5T_03810 2.82e-106 323.0 COG0572@1|root,COG0572@2|Bacteria,4NIHT@976|Bacteroidetes,2FP3D@200643|Bacteroidia 976|Bacteroidetes FJ Phosphoribulokinase Uridine kinase family udk2 - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK k59_823845_1 1227497.C491_20342 1.96e-45 159.0 COG0508@1|root,arCOG01706@2157|Archaea,2XUGY@28890|Euryarchaeota,23V33@183963|Halobacteria 183963|Halobacteria C COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes - - - - - - - - - - - - 2-oxoacid_dh k59_430835_1 1173024.KI912149_gene5587 5.04e-93 303.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,1JJJ8@1189|Stigonemataceae 1117|Cyanobacteria C Domain of unknown function nifJ GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - iJN678.nifJ EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_398773_2 509635.N824_18160 4.06e-51 169.0 28IRY@1|root,2Z8R6@2|Bacteria,4NIMI@976|Bacteroidetes,1INV2@117747|Sphingobacteriia 976|Bacteroidetes S Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 k59_334118_1 1168034.FH5T_12315 1.13e-214 610.0 COG2885@1|root,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,2FPQX@200643|Bacteroidia 976|Bacteroidetes MU Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - CarboxypepD_reg,OmpA,PD40 k59_235430_1 1319815.HMPREF0202_02318 7.94e-22 90.9 COG5011@1|root,COG5011@2|Bacteria,379AJ@32066|Fusobacteria 32066|Fusobacteria S Uncharacterized protein conserved in bacteria (DUF2344) - - - - - - - - - - - - DUF2344 k59_235430_2 401526.TcarDRAFT_1484 6.3e-34 142.0 COG3064@1|root,COG3064@2|Bacteria,1U2T9@1239|Firmicutes,4H255@909932|Negativicutes 909932|Negativicutes M SpoIVB peptidase S55 - - - - - - - - - - - - Peptidase_S55 k59_856578_1 1451261.AS96_01245 6.25e-15 79.3 COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria,4FNGP@85023|Microbacteriaceae 201174|Actinobacteria L by sequence - - - - - - - - - - - - HTH_38,rve k59_72142_1 643562.Daes_1583 3.84e-117 339.0 293DJ@1|root,2ZQW1@2|Bacteria,1RE56@1224|Proteobacteria,42ZFY@68525|delta/epsilon subdivisions,2WUVQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_430842_1 1168034.FH5T_07980 4.48e-46 152.0 COG1595@1|root,COG1595@2|Bacteria,4NQ7S@976|Bacteroidetes,2FTDI@200643|Bacteroidia 976|Bacteroidetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_430842_2 1168034.FH5T_07975 3.94e-39 141.0 2DP4F@1|root,330H1@2|Bacteria,4NX9Z@976|Bacteroidetes,2FVZZ@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_856579_1 563040.Saut_1878 2.03e-125 370.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2YNCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_530093_1 1129794.C427_4004 3.05e-11 68.9 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,4654Y@72275|Alteromonadaceae 1236|Gammaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component ybbP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_72145_1 933262.AXAM01000002_gene566 3.42e-67 224.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MHR5@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2 k59_823856_2 391587.KAOT1_21796 6.63e-21 97.8 28MMW@1|root,2ZAXH@2|Bacteria,4NKUW@976|Bacteroidetes,1HWZR@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - BetR k59_1019916_2 1000569.HMPREF1040_1446 1.33e-06 49.7 COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,4H5MZ@909932|Negativicutes 909932|Negativicutes J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_300245_1 889378.Spiaf_2001 4.27e-177 517.0 COG0469@1|root,COG0469@2|Bacteria,2J5VE@203691|Spirochaetes 203691|Spirochaetes G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C k59_594748_1 760568.Desku_1823 3.77e-06 52.4 COG1291@1|root,COG1291@2|Bacteria,1TRH1@1239|Firmicutes,24AEJ@186801|Clostridia,2616S@186807|Peptococcaceae 186801|Clostridia N PFAM MotA TolQ ExbB proton channel motA - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_334133_1 653733.Selin_1017 6.58e-125 367.0 COG0160@1|root,COG0160@2|Bacteria 2|Bacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family ectB - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_334133_2 83406.HDN1F_30600 7.48e-24 99.4 COG0454@1|root,COG0456@2|Bacteria,1RHB7@1224|Proteobacteria,1S3TD@1236|Gammaproteobacteria,1J67Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K L-2,4-diaminobutyric acid acetyltransferase ectA - 2.3.1.178 ko:K06718 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06978 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_267503_1 1168034.FH5T_16980 1.8e-48 165.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding Z012_05310 - - ko:K01420,ko:K10914,ko:K21556,ko:K21562 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1019920_1 2340.JV46_15090 1.28e-51 175.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1J4X6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889 Adenylsucc_synt k59_594751_1 1150621.SMUL_0142 1.42e-12 72.0 2AIM2@1|root,319HK@2|Bacteria,1Q2ST@1224|Proteobacteria,42W74@68525|delta/epsilon subdivisions,2YQAM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_594751_2 1355374.JARU01000006_gene1713 8.06e-14 68.6 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,42SVZ@68525|delta/epsilon subdivisions,2YPE3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_888546_1 572544.Ilyop_1253 1.31e-92 291.0 COG2213@1|root,COG4668@1|root,COG2213@2|Bacteria,COG4668@2|Bacteria,37BBV@32066|Fusobacteria 32066|Fusobacteria G TIGRFAM PTS system, mannitol-specific IIC subunit - - 2.7.1.197 ko:K02798,ko:K02799,ko:K02800 ko00051,ko02060,map00051,map02060 M00274 R02704 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5 - - PTS_EIIC,PTS_IIB k59_888546_2 572544.Ilyop_1255 6.07e-18 82.8 COG0449@1|root,COG0449@2|Bacteria,37979@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_105271_1 566466.NOR53_737 1.01e-32 120.0 28H8Z@1|root,2Z7KS@2|Bacteria,1MW9T@1224|Proteobacteria,1RQV1@1236|Gammaproteobacteria,1J6DS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Yip1 domain - - - - - - - - - - - - DUF1282 k59_105271_2 395493.BegalDRAFT_0212 4.59e-125 369.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,460AT@72273|Thiotrichales 72273|Thiotrichales C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_660920_4 574376.BAMA_12435 1.81e-22 100.0 COG3935@1|root,COG3935@2|Bacteria,1TSHD@1239|Firmicutes,4HIGY@91061|Bacilli,1ZCUE@1386|Bacillus 91061|Bacilli L Conserved phage C-terminus (Phg_2220_C) - - - - - - - - - - - - Phage_rep_org_N,Phg_2220_C k59_660920_5 697281.Mahau_2458 5.86e-07 56.6 COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,25CG0@186801|Clostridia,42J1W@68295|Thermoanaerobacterales 186801|Clostridia L PFAM IstB domain protein ATP-binding protein - - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 k59_530112_2 713587.THITH_10355 9.9e-55 186.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,NADH-G_4Fe-4S_3 k59_725550_1 1206729.BAFZ01000162_gene5541 1.33e-27 115.0 2E31E@1|root,32Y1T@2|Bacteria,2H6XE@201174|Actinobacteria 201174|Actinobacteria S Bacillus haemolytic enterotoxin (HBL) - - - - - - - - - - - - Bacillus_HBL k59_987290_1 105559.Nwat_0437 1.55e-65 211.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales 135613|Chromatiales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_987290_2 1005048.CFU_2212 1.86e-84 258.0 COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,2VMSE@28216|Betaproteobacteria,475QB@75682|Oxalobacteraceae 28216|Betaproteobacteria S Methyltransferase domain mdmC - - - - - - - - - - - Methyltransf_3 k59_398803_1 631362.Thi970DRAFT_04267 5.81e-87 273.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales 135613|Chromatiales E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_202671_1 1168034.FH5T_04775 9.68e-101 303.0 COG0436@1|root,COG0436@2|Bacteria,4NFWS@976|Bacteroidetes,2FMMU@200643|Bacteroidia 976|Bacteroidetes H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_987292_1 1172190.M947_02545 1.85e-123 368.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1019932_2 768671.ThimaDRAFT_1748 8.23e-115 336.0 COG0650@1|root,COG0650@2|Bacteria,1QE37@1224|Proteobacteria,1RZJC@1236|Gammaproteobacteria,1WWZT@135613|Chromatiales 135613|Chromatiales C pfam nadh - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_856931_35 449447.MAE_36780 1.34e-53 187.0 COG0662@1|root,COG5424@1|root,COG0662@2|Bacteria,COG5424@2|Bacteria,1G4DZ@1117|Cyanobacteria 1117|Cyanobacteria H Iron-containing redox enzyme - - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - Haem_oxygenas_2 k59_856931_36 864073.HFRIS_000940 3.92e-198 575.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,473VE@75682|Oxalobacteraceae 28216|Betaproteobacteria P monovalent cation proton kefC - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_856931_37 118166.JH976537_gene2632 3.88e-51 170.0 COG2249@1|root,COG2249@2|Bacteria,1G57U@1117|Cyanobacteria,1HEJ4@1150|Oscillatoriales 1117|Cyanobacteria S Flavodoxin-like fold - - - ko:K03923,ko:K11748 - - - - ko00000,ko02000 2.A.37.1.2 - - Flavodoxin_2 k59_856931_38 404589.Anae109_4173 9.02e-106 315.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,432D0@68525|delta/epsilon subdivisions,2WY0P@28221|Deltaproteobacteria,2Z211@29|Myxococcales 28221|Deltaproteobacteria C Oxidoreductase NAD-binding domain - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_856931_39 396588.Tgr7_2418 2.48e-26 97.1 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,1SC8Q@1236|Gammaproteobacteria,1WZ6V@135613|Chromatiales 135613|Chromatiales C PFAM Rubredoxin-type Fe(Cys)4 protein - - - - - - - - - - - - Rubredoxin k59_856931_40 1322246.BN4_10404 8.98e-260 728.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42MV2@68525|delta/epsilon subdivisions,2WJ7U@28221|Deltaproteobacteria,2M839@213115|Desulfovibrionales 28221|Deltaproteobacteria H TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_856931_41 85643.Tmz1t_3075 7.95e-38 129.0 COG0440@1|root,COG0440@2|Bacteria,1N065@1224|Proteobacteria,2VV2S@28216|Betaproteobacteria,2KWWN@206389|Rhodocyclales 206389|Rhodocyclales E Acetolactate synthase small ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5 k59_856931_42 156889.Mmc1_0831 7.06e-65 204.0 COG1476@1|root,COG1917@1|root,COG1476@2|Bacteria,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,HTH_3,HTH_31 k59_856931_43 1288826.MSNKSG1_05466 3.88e-30 120.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,466GX@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_856931_44 1049564.TevJSym_au00620 2.28e-162 461.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1J4VY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0568 DNA-directed RNA polymerase, sigma subunit rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_856931_45 1245471.PCA10_45040 9.62e-59 196.0 COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1YE6T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria D Peptidase family M23 nlpD GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944 - ko:K06194,ko:K12943 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_856931_46 765912.Thimo_1331 2.49e-82 249.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria,1WY8B@135613|Chromatiales 135613|Chromatiales S PFAM SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_856931_47 1026882.MAMP_01302 4.12e-83 253.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,460E3@72273|Thiotrichales 72273|Thiotrichales O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_856931_48 1049564.TevJSym_au00580 4.23e-126 363.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1J5TA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - iSFxv_1172.SFxv_3035 SurE k59_856931_49 472759.Nhal_3018 1.16e-50 168.0 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1S6B5@1236|Gammaproteobacteria,1X2FV@135613|Chromatiales 135613|Chromatiales S Smr protein - - - - - - - - - - - - Smr k59_856931_50 1415778.JQMM01000001_gene1991 3.3e-187 540.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,1RQ1A@1236|Gammaproteobacteria,1J4GI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MBOAT, membrane-bound O-acyltransferase family algI - - - - - - - - - - - MBOAT k59_856931_51 1415778.JQMM01000001_gene1990 6.07e-88 278.0 28HH1@1|root,30II1@2|Bacteria,1PW9N@1224|Proteobacteria,1THYJ@1236|Gammaproteobacteria,1JBH7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_856931_52 1244869.H261_12506 2.6e-20 90.1 2CHMD@1|root,32VUS@2|Bacteria,1MZMB@1224|Proteobacteria,2UC8Z@28211|Alphaproteobacteria,2JUJN@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - DUF4405 k59_856931_53 312153.Pnuc_1096 8.43e-97 336.0 COG0457@1|root,COG0859@1|root,COG3118@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,COG3118@2|Bacteria,1PEV4@1224|Proteobacteria,2W92U@28216|Betaproteobacteria,1K1Y1@119060|Burkholderiaceae 28216|Betaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_10,TPR_16,TPR_2,TPR_8 k59_856931_54 857087.Metme_3414 7.54e-107 323.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1XDYC@135618|Methylococcales 135618|Methylococcales J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_856931_55 999141.GME_00665 1.1e-61 194.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1XJPI@135619|Oceanospirillales 135619|Oceanospirillales I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB k59_856931_56 305900.GV64_16155 6.59e-82 251.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1XJRE@135619|Oceanospirillales 135619|Oceanospirillales I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_856931_57 580332.Slit_1883 1.78e-17 78.2 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,44W01@713636|Nitrosomonadales 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_38879_1 1313301.AUGC01000011_gene1166 5.53e-28 110.0 COG0859@1|root,COG0859@2|Bacteria,4NEPH@976|Bacteroidetes 976|Bacteroidetes M heptosyltransferase - - - - - - - - - - - - Glyco_transf_9 k59_954755_1 338963.Pcar_0024 5.45e-79 244.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,42MC1@68525|delta/epsilon subdivisions,2WJ24@28221|Deltaproteobacteria,43UKS@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_203391_1 1318628.MARLIPOL_13374 1.07e-07 54.7 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,466QS@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG1214 Inactive homolog of metal-dependent proteases yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_203391_2 159087.Daro_1574 1.83e-07 53.5 COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,2KYCZ@206389|Rhodocyclales 206389|Rhodocyclales T Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365,HATPase_c,HisKA,PAS_9,Response_reg k59_498016_1 1121344.JHZO01000005_gene154 5.58e-12 72.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - 3.4.21.107 ko:K04771,ko:K20276 ko01503,ko02020,ko02024,map01503,map02020,map02024 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PEGA,PPC,SLH,Trypsin_2 k59_236104_1 338966.Ppro_1009 6.54e-65 212.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42T20@68525|delta/epsilon subdivisions,2WP7S@28221|Deltaproteobacteria,43W22@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_889232_1 177437.HRM2_15130 1.23e-74 238.0 COG5557@1|root,COG5557@2|Bacteria,1QURB@1224|Proteobacteria,43BT1@68525|delta/epsilon subdivisions,2X73S@28221|Deltaproteobacteria,2MMX3@213118|Desulfobacterales 28221|Deltaproteobacteria C Pfam Polysulphide reductase, NrfD actF - - - - - - - - - - - - k59_399455_1 765912.Thimo_3042 1.4e-73 238.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1WW6M@135613|Chromatiales 135613|Chromatiales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_72878_1 1217705.F900_00047 9.82e-19 87.8 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,3NJYF@468|Moraxellaceae 1236|Gammaproteobacteria C Iron-containing alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_4693_1 1121957.ATVL01000011_gene3853 2.16e-32 120.0 COG1670@1|root,COG1670@2|Bacteria,4NQB5@976|Bacteroidetes,47RAN@768503|Cytophagia 976|Bacteroidetes J PFAM Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_3 k59_268045_1 1168034.FH5T_04175 1.36e-116 366.0 COG0085@1|root,COG0085@2|Bacteria,4NF8D@976|Bacteroidetes,2FMDI@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_236112_1 439235.Dalk_1214 1.79e-68 239.0 COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_889239_1 1249480.B649_00245 2.79e-37 144.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,42NGP@68525|delta/epsilon subdivisions,2YN81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar hook protein flgE flgE GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flagellin_IN,Flg_bb_rod,Flg_bbr_C k59_726118_1 999541.bgla_1g00910 7.29e-35 127.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,1K209@119060|Burkholderiaceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_726118_2 1266925.JHVX01000005_gene1933 2.09e-24 102.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,371UU@32003|Nitrosomonadales 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_824517_1 572477.Alvin_3114 6.32e-191 550.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_758669_1 1225184.ALXE01000031_gene4273 1.64e-08 66.6 COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,3W1I8@53335|Pantoea 1236|Gammaproteobacteria Q von willebrand factor, type A - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2 k59_824520_1 873517.HMPREF1977_0906 1.35e-60 197.0 COG0332@1|root,COG0332@2|Bacteria,4NEYH@976|Bacteroidetes,1HX72@117743|Flavobacteriia,1EQ4S@1016|Capnocytophaga 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_465425_1 1442599.JAAN01000047_gene2922 4.86e-81 247.0 COG4555@1|root,COG4555@2|Bacteria,1QU2T@1224|Proteobacteria,1RY2V@1236|Gammaproteobacteria,1X307@135614|Xanthomonadales 135614|Xanthomonadales CP abc transporter atp-binding protein - - 3.6.3.7 ko:K09697 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.115 - - ABC_tran k59_563404_1 387093.SUN_1997 8.64e-66 224.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2YMW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_824522_1 388051.AUFE01000040_gene3224 1.35e-41 155.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,2VGZ6@28216|Betaproteobacteria,1JZQD@119060|Burkholderiaceae 28216|Betaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_367158_1 396588.Tgr7_0658 2.08e-37 133.0 COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family csgA - - - - - - - - - - - adh_short k59_367158_2 768671.ThimaDRAFT_1207 2.37e-13 70.5 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales 135613|Chromatiales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_923119_1 1537917.JU82_11520 4.96e-150 442.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2YM83@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_236127_1 398720.MED217_09465 4.21e-07 56.6 COG0679@1|root,COG0679@2|Bacteria,4NGI3@976|Bacteroidetes,1HZ1K@117743|Flavobacteriia,2XJ0V@283735|Leeuwenhoekiella 976|Bacteroidetes S Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - - k59_758685_1 1232410.KI421413_gene787 7.4e-82 253.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,42NEF@68525|delta/epsilon subdivisions,2WIVI@28221|Deltaproteobacteria,43U26@69541|Desulfuromonadales 28221|Deltaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_138746_1 1321815.HMPREF9193_02084 5.13e-50 171.0 COG0216@1|root,COG0216@2|Bacteria,2J5KY@203691|Spirochaetes 203691|Spirochaetes J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_498067_1 644282.Deba_0295 8.84e-82 257.0 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_856987_1 1458357.BG58_16735 1.37e-16 84.3 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,1KG5N@119060|Burkholderiaceae 28216|Betaproteobacteria IQ amp-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,Acyltransferase,PP-binding k59_106020_1 1123276.KB893301_gene4321 6.78e-32 128.0 COG3292@1|root,COG5002@1|root,COG3292@2|Bacteria,COG5002@2|Bacteria,4NJ2Y@976|Bacteroidetes,47N0D@768503|Cytophagia 976|Bacteroidetes T Y_Y_Y domain - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,HisKA_2,Reg_prop,Response_reg,Y_Y_Y k59_1020597_1 1165841.SULAR_09949 1.5e-58 185.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2YNYN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H riboflavin synthase alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_824540_1 326298.Suden_0571 2.91e-38 140.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H ATP citrate synthase - - 2.3.3.8 ko:K15230 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,Ligase_CoA k59_824540_2 1165841.SULAR_08719 1.15e-103 310.0 COG0045@1|root,COG0045@2|Bacteria,1PYM0@1224|Proteobacteria,42YXJ@68525|delta/epsilon subdivisions,2YR3Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C ATP citrate lyase citrate-binding - - - - - - - - - - - - ATP-grasp_2,Citrate_bind k59_954805_1 1049564.TevJSym_bb00290 8.2e-100 318.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T216@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg k59_856992_2 572544.Ilyop_1349 2.94e-44 167.0 COG1480@1|root,COG1480@2|Bacteria,378ZH@32066|Fusobacteria 32066|Fusobacteria S 7TM receptor with intracellular HD hydrolase - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_38934_1 1230342.CTM_14953 1.22e-07 53.5 COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,248C8@186801|Clostridia,36IDY@31979|Clostridiaceae 186801|Clostridia S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_38934_2 439235.Dalk_4697 1.64e-81 253.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,43BJA@68525|delta/epsilon subdivisions,2WME6@28221|Deltaproteobacteria,2MKN5@213118|Desulfobacterales 28221|Deltaproteobacteria O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_38934_3 755178.Cyan10605_2555 4.26e-46 156.0 COG1225@1|root,COG1225@2|Bacteria,1G3WF@1117|Cyanobacteria 1117|Cyanobacteria O PFAM AhpC TSA family - - - - - - - - - - - - AhpC-TSA k59_889279_1 765912.Thimo_0143 1.51e-117 345.0 COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,1RSIM@1236|Gammaproteobacteria,1WW7Y@135613|Chromatiales 135613|Chromatiales C reductase, dissimilatory-type alpha subunit - - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_988024_1 270374.MELB17_07309 3.7e-56 188.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,464WH@72275|Alteromonadaceae 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_726158_1 1443665.JACA01000013_gene4229 9.1e-58 203.0 COG3422@1|root,COG3422@2|Bacteria,4NHE4@976|Bacteroidetes,1I0UZ@117743|Flavobacteriia,2YHEU@290174|Aquimarina 976|Bacteroidetes S double-strand break repair - - - - - - - - - - - - - k59_726159_1 340177.Cag_0645 4.18e-50 169.0 2DQMF@1|root,337KW@2|Bacteria,1FESM@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - k59_563430_1 742735.HMPREF9467_03377 1.2e-69 223.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,24BWQ@186801|Clostridia,221MA@1506553|Lachnoclostridium 186801|Clostridia G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_563430_2 290402.Cbei_0449 2.31e-177 505.0 COG4225@1|root,COG4225@2|Bacteria,1TS2C@1239|Firmicutes,249FU@186801|Clostridia,36H86@31979|Clostridiaceae 186801|Clostridia S PFAM Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_563430_3 714961.BFZC1_20423 6.87e-14 75.5 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,4HB9M@91061|Bacilli,3J028@400634|Lysinibacillus 91061|Bacilli K helix_turn _helix lactose operon repressor - - - - - - - - - - - - LacI,Peripla_BP_3 k59_628629_1 1121403.AUCV01000016_gene4399 6.01e-87 283.0 COG0438@1|root,COG1409@1|root,COG0438@2|Bacteria,COG1409@2|Bacteria,1MUB7@1224|Proteobacteria,42PT6@68525|delta/epsilon subdivisions,2WK6I@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.345 ko:K08256 - - R11702 - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_4731_1 1168065.DOK_14984 2.85e-92 286.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1J4QJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EQ Hydantoinase B/oxoprolinase hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_790911_1 1168289.AJKI01000044_gene3 3.11e-37 140.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,2FMXD@200643|Bacteroidia 976|Bacteroidetes G Alpha-1,2-mannosidase - - - - - - - - - - - - Glyco_hydro_92 k59_790911_2 1120968.AUBX01000012_gene2909 3.68e-54 187.0 COG3975@1|root,COG3975@2|Bacteria,4NGTY@976|Bacteroidetes,47KE2@768503|Cytophagia 976|Bacteroidetes S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_693817_1 1265313.HRUBRA_00546 6.91e-17 90.9 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1RZRN@1236|Gammaproteobacteria,1JB5Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Tetratricopeptide repeat - - - - - - - - - - - - GGDEF,TPR_12,TPR_7 k59_693817_2 941639.BCO26_2233 1.53e-17 86.7 COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,4HBE6@91061|Bacilli,1ZAVD@1386|Bacillus 91061|Bacilli S Carboxylesterase est GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Hydrolase_4 k59_693817_3 1499967.BAYZ01000170_gene5494 5.99e-50 162.0 COG2154@1|root,COG2154@2|Bacteria 2|Bacteria H pterin-4-alpha-carbinolamine dehydratase phhB GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_693817_4 264730.PSPPH_1501 1.21e-35 125.0 2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,1SA77@1236|Gammaproteobacteria,1ZA32@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 k59_498102_1 926569.ANT_04660 3.52e-62 200.0 COG0463@1|root,COG0463@2|Bacteria,2G5JH@200795|Chloroflexi 200795|Chloroflexi M PFAM Glycosyl transferase family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_498102_2 926569.ANT_04670 8.88e-11 62.0 COG0498@1|root,COG0498@2|Bacteria,2G6D6@200795|Chloroflexi 200795|Chloroflexi E Pyridoxal-phosphate dependent enzyme - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_72947_1 1168034.FH5T_12815 2.67e-109 317.0 COG0087@1|root,COG0087@2|Bacteria,4NEAN@976|Bacteroidetes,2FMS5@200643|Bacteroidia 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_498108_2 1173027.Mic7113_3147 2.54e-40 145.0 COG5634@1|root,COG5634@2|Bacteria,1G45V@1117|Cyanobacteria,1HAXN@1150|Oscillatoriales 1117|Cyanobacteria S Uncharacterized conserved protein (DUF2278) - - - - - - - - - - - - DUF2278,LTD k59_889307_1 1168034.FH5T_16805 3.42e-66 205.0 COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia 976|Bacteroidetes O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_531504_2 1307759.JOMJ01000004_gene2850 3.41e-30 117.0 COG3635@1|root,COG3635@2|Bacteria,1R4TM@1224|Proteobacteria,42NCT@68525|delta/epsilon subdivisions,2WKEG@28221|Deltaproteobacteria,2M9P8@213115|Desulfovibrionales 28221|Deltaproteobacteria G Phosphonopyruvate decarboxylase-related protein apgM - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_726685_1 1165841.SULAR_06158 4.94e-108 323.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2YMIC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_889931_1 1316936.K678_05328 3.32e-29 117.0 COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JV9T@204441|Rhodospirillales 204441|Rhodospirillales CJ COG1042 Acyl-CoA synthetase (NDP forming) - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_889931_2 1232410.KI421419_gene2478 5.86e-19 85.5 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,43RYP@69541|Desulfuromonadales 28221|Deltaproteobacteria C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2763 Aconitase,Aconitase_C k59_204101_2 1123073.KB899241_gene1880 2.01e-42 147.0 COG1595@1|root,COG1595@2|Bacteria,1N3BR@1224|Proteobacteria,1SCCR@1236|Gammaproteobacteria,1X4U8@135614|Xanthomonadales 135614|Xanthomonadales K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF k59_923702_1 314287.GB2207_04059 3.25e-28 121.0 COG0457@1|root,COG0457@2|Bacteria,1RC07@1224|Proteobacteria,1S36N@1236|Gammaproteobacteria,1J5XV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 k59_399925_1 497321.C664_09695 1.05e-91 284.0 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,2KUX8@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the peptidase S11 family pbp - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_399925_2 1318628.MARLIPOL_12500 1.23e-91 293.0 COG2982@1|root,COG2982@2|Bacteria,1NARH@1224|Proteobacteria,1SE5J@1236|Gammaproteobacteria,468PT@72275|Alteromonadaceae 1236|Gammaproteobacteria M Protein involved in outer membrane biogenesis - - - - - - - - - - - - AsmA,AsmA_2 k59_399925_3 1279017.AQYJ01000020_gene1217 9.09e-75 268.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,464Y3@72275|Alteromonadaceae 1236|Gammaproteobacteria T GGDEF domain - - - - - - - - - - - - 7TMR-DISMED2,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_399925_4 290512.Paes_1915 1.52e-36 142.0 COG1572@1|root,COG1572@2|Bacteria,1FEDB@1090|Chlorobi 2|Bacteria S cell adhesion involved in biofilm formation - - - - - - - - - - - - CARDB k59_399925_5 314345.SPV1_10651 2.1e-07 50.1 2EIC1@1|root,33C3D@2|Bacteria,1NHMH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - Rho_N k59_399925_6 765913.ThidrDRAFT_3366 7.47e-161 477.0 COG3291@1|root,COG3291@2|Bacteria,1QU15@1224|Proteobacteria,1T1KN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pkd domain containing protein - - - - - - - - - - - - - k59_399925_7 1300345.LF41_681 4.3e-138 404.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1X3TB@135614|Xanthomonadales 135614|Xanthomonadales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_399925_8 511062.GU3_14640 2.39e-113 337.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1Y4E5@135624|Aeromonadales 135624|Aeromonadales V ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_399925_9 1442599.JAAN01000030_gene2131 2.61e-35 135.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria,1X4UP@135614|Xanthomonadales 135614|Xanthomonadales M secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_399925_10 1249627.D779_3650 3.11e-55 182.0 COG1309@1|root,COG1309@2|Bacteria,1N1X6@1224|Proteobacteria,1S9GI@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_399925_11 686340.Metal_3536 1.78e-108 320.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,1RQKK@1236|Gammaproteobacteria,1XE0S@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_399925_12 1026882.MAMP_01801 5.98e-234 668.0 COG3083@1|root,COG3083@2|Bacteria,1MX6X@1224|Proteobacteria,1RPAU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolase of alkaline phosphatase superfamily - - - ko:K07014 - - - - ko00000 - - - DUF3413,Sulfatase k59_399925_13 765911.Thivi_2762 6.58e-82 255.0 COG1639@1|root,COG1639@2|Bacteria,1RERP@1224|Proteobacteria,1RPGC@1236|Gammaproteobacteria,1WXUF@135613|Chromatiales 135613|Chromatiales T Signal transduction protein - - - - - - - - - - - - HDOD k59_399925_14 765911.Thivi_2761 6.5e-231 661.0 COG2804@1|root,COG2804@2|Bacteria,1QTCB@1224|Proteobacteria,1RY2Z@1236|Gammaproteobacteria,1X2CN@135613|Chromatiales 135613|Chromatiales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_399925_15 2340.JV46_19350 5.03e-225 630.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J53P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ammonium Transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_399925_16 1232437.KL662042_gene2036 1.09e-72 224.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,42SFZ@68525|delta/epsilon subdivisions,2WPY5@28221|Deltaproteobacteria,2MNXZ@213118|Desulfobacterales 28221|Deltaproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_399925_17 2340.JV46_24000 9.72e-204 572.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,1J4R2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_399925_18 1255043.TVNIR_2334 1.42e-93 299.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales 135613|Chromatiales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_335577_1 1121937.AUHJ01000014_gene2661 1.4e-10 65.1 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,467ZS@72275|Alteromonadaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_301418_1 686340.Metal_0302 1.64e-123 365.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1XECN@135618|Methylococcales 135618|Methylococcales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_367829_1 1249480.B649_04640 1.45e-33 127.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2YMX4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_367829_2 326298.Suden_0997 4.58e-45 151.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2YNEP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_955357_1 313590.MED134_03264 6.71e-87 262.0 COG0346@1|root,COG0346@2|Bacteria,4NQSP@976|Bacteroidetes,1I1G3@117743|Flavobacteriia 976|Bacteroidetes E ring-cleavage extradiol dioxygenase - - - - - - - - - - - - Glyoxalase k59_106677_1 29495.EA26_20330 8.82e-70 224.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1XSFE@135623|Vibrionales 135623|Vibrionales I Biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_73598_1 1255043.TVNIR_3103 8.48e-105 317.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales 135613|Chromatiales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_301423_1 1123368.AUIS01000019_gene1212 1.78e-42 148.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RMII@1236|Gammaproteobacteria,2NC3Y@225057|Acidithiobacillales 225057|Acidithiobacillales C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN k59_301423_2 1121405.dsmv_0001 6.14e-42 142.0 COG4843@1|root,COG4843@2|Bacteria,1REIP@1224|Proteobacteria,42S29@68525|delta/epsilon subdivisions,2WNWG@28221|Deltaproteobacteria,2MKCT@213118|Desulfobacterales 28221|Deltaproteobacteria S protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 k59_268589_1 765912.Thimo_0108 2.33e-78 244.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria,1WWYR@135613|Chromatiales 135613|Chromatiales S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_5102_1 247639.MGP2080_01706 2.98e-77 245.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,1RPA1@1236|Gammaproteobacteria,1J9NV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases - - - - - - - - - - - - FMN_dh k59_301428_1 387093.SUN_0190 1.24e-31 117.0 COG0242@1|root,COG0242@2|Bacteria,1QNIH@1224|Proteobacteria,42TAD@68525|delta/epsilon subdivisions,2YPKH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J COG0242 N-formylmethionyl-tRNA deformylase - - - - - - - - - - - - Pep_deformylase k59_301428_2 1172190.M947_02525 1.84e-33 119.0 COG0247@1|root,COG0247@2|Bacteria,1Q4WT@1224|Proteobacteria,4301Q@68525|delta/epsilon subdivisions,2YRXT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_988666_2 1448860.BBJO01000055_gene75 4.06e-47 167.0 COG3839@1|root,arCOG00177@2157|Archaea,2XTFK@28890|Euryarchaeota,23S9H@183963|Halobacteria 183963|Halobacteria E COG3842 ABC-type spermidine putrescine transport systems, ATPase components sfuC - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_988666_4 857087.Metme_4161 1.27e-84 266.0 COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,1RPP5@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC transporter substrate-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_596247_1 1298865.H978DRAFT_0392 1.52e-27 115.0 COG2911@1|root,COG3210@1|root,COG3291@1|root,COG4932@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,465B9@72275|Alteromonadaceae 1236|Gammaproteobacteria M Bacterial Ig-like domain (group 3) - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3 k59_1021229_1 1121033.AUCF01000010_gene4406 7.43e-13 73.2 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2JPSK@204441|Rhodospirillales 204441|Rhodospirillales S ABC1 family - - - - - - - - - - - - ABC1 k59_73612_1 1165841.SULAR_05818 1.61e-93 285.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2YMZK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_662264_1 387093.SUN_0965 2.57e-126 367.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,42P2E@68525|delta/epsilon subdivisions,2YNPW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - Radical_SAM k59_662264_2 1355374.JARU01000003_gene1155 8.65e-48 166.0 COG0095@1|root,COG0095@2|Bacteria,1RI3T@1224|Proteobacteria,42SQP@68525|delta/epsilon subdivisions,2YPI5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Biotin/lipoate A/B protein ligase family - - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_498767_1 1174528.JH992892_gene6341 1.55e-33 128.0 COG5421@1|root,COG5421@2|Bacteria,1G4EU@1117|Cyanobacteria 1117|Cyanobacteria L IMG reference gene - - - - - - - - - - - - - k59_335612_1 215803.DB30_5379 9.86e-40 145.0 COG1075@1|root,COG1075@2|Bacteria,1NIPT@1224|Proteobacteria 1224|Proteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_106704_1 929558.SMGD1_1829 4.59e-89 268.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2YMU9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_432183_1 177437.HRM2_03260 2.11e-106 318.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MIKK@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_139415_1 1280680.AUJU01000007_gene2249 1.4e-23 97.4 COG0395@1|root,COG0395@2|Bacteria,1TRB1@1239|Firmicutes,2488P@186801|Clostridia,4BWP2@830|Butyrivibrio 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_139415_2 1469948.JPNB01000002_gene2806 8.38e-54 186.0 COG1653@1|root,COG1653@2|Bacteria,1TPHG@1239|Firmicutes,24AFQ@186801|Clostridia,36GZA@31979|Clostridiaceae 186801|Clostridia G ABC transporter substrate-binding protein - - - ko:K02027,ko:K17318 ko02010,map02010 M00207,M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.29,3.A.1.1.9 - - - k59_825142_1 1189612.A33Q_0622 1.22e-22 102.0 COG1629@1|root,COG1629@2|Bacteria,4NF88@976|Bacteroidetes,47JEF@768503|Cytophagia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 k59_889955_1 1304880.JAGB01000002_gene1553 6.33e-88 269.0 COG1814@1|root,COG1814@2|Bacteria,1UZVX@1239|Firmicutes,24BSJ@186801|Clostridia 186801|Clostridia S VIT family - - - - - - - - - - - - Rubrerythrin,VIT1 k59_889955_2 523794.Lebu_0460 9.97e-81 246.0 COG2129@1|root,COG2129@2|Bacteria,37AH8@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Metallophos k59_889955_3 526218.Sterm_1745 1.83e-121 380.0 COG1475@1|root,COG1475@2|Bacteria,37ACB@32066|Fusobacteria 32066|Fusobacteria K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF4032 k59_889955_4 1282887.AUJG01000001_gene1863 5.36e-108 333.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia 186801|Clostridia EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_335635_1 762968.HMPREF9441_01129 2.03e-57 201.0 COG3533@1|root,COG4733@1|root,COG3533@2|Bacteria,COG4733@2|Bacteria,4NINK@976|Bacteroidetes,2FS7P@200643|Bacteroidia 976|Bacteroidetes S Alginate lyase - - - - - - - - - - - - Alginate_lyase,Laminin_G_3 k59_857620_1 1384056.N787_10265 6.46e-17 86.7 COG0457@1|root,COG0457@2|Bacteria,1N06S@1224|Proteobacteria,1S516@1236|Gammaproteobacteria,1XCBP@135614|Xanthomonadales 135614|Xanthomonadales S MTH538 TIR-like domain (DUF1863) - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - DUF1863,WD40 k59_564078_1 387093.SUN_2153 2.72e-86 273.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2YMUE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_759353_1 1385515.N791_06510 1.1e-38 142.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,1X31G@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_759353_2 1123514.KB905901_gene42 0.000203 43.5 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,460K9@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_629346_1 537972.ABQU01000009_gene241 3.91e-12 65.5 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2YMB9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T chemotaxis protein cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_629346_2 929558.SMGD1_0605 5.59e-69 218.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,42M00@68525|delta/epsilon subdivisions,2YMF1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T chemotaxis protein cheV - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_498790_2 2340.JV46_11730 8.18e-35 125.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1J6NQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases hit1 - - - - - - - - - - - HIT k59_857625_1 929713.NIASO_08090 1.26e-93 305.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1IV3D@117747|Sphingobacteriia 976|Bacteroidetes H TIGRFAM TonB-dependent outer membrane receptor, SusC RagA subfamily, signature region - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_564081_1 1121438.JNJA01000006_gene309 2.71e-136 393.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,2M8UU@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rmlA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_5128_1 1123368.AUIS01000009_gene2439 1.29e-20 94.4 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria 1236|Gammaproteobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Glyco_hydro_77 k59_399977_1 870187.Thini_2424 5.82e-31 120.0 COG3039@1|root,COG3039@2|Bacteria,1Q9AW@1224|Proteobacteria,1RNU1@1236|Gammaproteobacteria,460GH@72273|Thiotrichales 72273|Thiotrichales L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_3 k59_498795_1 745014.OMB55_00000680 1.69e-79 246.0 COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Secreted protein, containing von Willebrand factor (VWF) type - - - - - - - - - - - - - k59_825155_1 172088.AUGA01000021_gene5169 8.59e-82 252.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,3JSM0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_827935_1 643648.Slip_1733 1.49e-27 114.0 COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,42KAU@68298|Syntrophomonadaceae 186801|Clostridia NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_893222_1 97138.C820_02324 1.3e-51 171.0 COG1811@1|root,COG1811@2|Bacteria,1UH19@1239|Firmicutes,24AZ3@186801|Clostridia,36FKD@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF554) - - - ko:K07150 - - - - ko00000 - - - DUF554 k59_793090_1 1123073.KB899244_gene261 1.75e-53 194.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5CT@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_174915_2 318586.Pden_2852 1.15e-49 171.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,2PW0I@265|Paracoccus 28211|Alphaproteobacteria C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_697167_1 472759.Nhal_0095 1.9e-172 496.0 COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1WX4C@135613|Chromatiales 135613|Chromatiales F Synthesizes alpha-1,4-glucan chains using ADP-glucose - - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_142726_2 1078083.HMPREF1208_01998 9.89e-27 112.0 COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,4HAZ0@91061|Bacilli,4GXBK@90964|Staphylococcaceae 91061|Bacilli P Na+/Pi-cotransporter yjbB - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_991894_1 709991.Odosp_1410 4.8e-07 50.1 COG2865@1|root,COG2865@2|Bacteria,4NGPG@976|Bacteroidetes,2FMWB@200643|Bacteroidia,22XSV@171551|Porphyromonadaceae 976|Bacteroidetes K Putative DNA-binding domain - - - - - - - - - - - - AlbA_2 k59_991894_2 1168034.FH5T_11820 6.53e-76 229.0 COG0454@1|root,COG0456@2|Bacteria,4NT3M@976|Bacteroidetes,2FYWS@200643|Bacteroidia 976|Bacteroidetes J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_338883_1 316056.RPC_2083 5.11e-73 237.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,3JSIB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_534790_1 1168034.FH5T_00250 2.94e-34 118.0 COG4628@1|root,COG4628@2|Bacteria,4NUS1@976|Bacteroidetes 976|Bacteroidetes S conserved protein (DUF2132) - - - - - - - - - - - - VF530 k59_502055_1 1151116.Q7S_14700 1.46e-41 155.0 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,3FGN9@34037|Rahnella 1236|Gammaproteobacteria E ABC-type oligopeptide transport system, periplasmic component oppA3 - - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_207402_1 1168034.FH5T_12235 1.38e-94 302.0 COG0574@1|root,COG0574@2|Bacteria,4NGSQ@976|Bacteroidetes,2FM60@200643|Bacteroidia 976|Bacteroidetes GKT Pyruvate phosphate dikinase, PEP pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_599630_1 929558.SMGD1_0386 5.75e-19 90.9 COG0840@1|root,COG0840@2|Bacteria,1N5N4@1224|Proteobacteria,42RSG@68525|delta/epsilon subdivisions,2YRU6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_109418_1 1089545.KB913037_gene847 1.45e-97 296.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4E4W8@85010|Pseudonocardiales 201174|Actinobacteria L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_32 k59_991903_1 929562.Emtol_2032 1.38e-74 249.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47N25@768503|Cytophagia 976|Bacteroidetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_370825_1 1307759.JOMJ01000003_gene989 4.69e-112 339.0 COG0603@1|root,COG0603@2|Bacteria,1MXFU@1224|Proteobacteria,42T68@68525|delta/epsilon subdivisions,2WS4G@28221|Deltaproteobacteria,2MC6S@213115|Desulfovibrionales 28221|Deltaproteobacteria F PP-loop superfamily ATPase - - - - - - - - - - - - QueC k59_762003_1 1121861.KB899918_gene3270 8.22e-23 100.0 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,2JPA7@204441|Rhodospirillales 204441|Rhodospirillales I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) ispDF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_174933_1 450851.PHZ_c3198 2.37e-50 174.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,2KFI3@204458|Caulobacterales 204458|Caulobacterales C oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_174933_2 977880.RALTA_B1726 1.69e-16 78.2 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,1JZPY@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome d ubiquinol oxidase, subunit II cioB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_958394_1 471854.Dfer_0792 2.31e-26 112.0 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG4977@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,COG4977@2|Bacteria,4NDXU@976|Bacteroidetes,47JBS@768503|Cytophagia 976|Bacteroidetes T Two component regulator propeller - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_174937_1 395494.Galf_0655 4.9e-83 265.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,44W8Q@713636|Nitrosomonadales 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_893253_1 1538295.JY96_08270 2.65e-51 180.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,1KJ9F@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_893253_2 1449351.RISW2_22190 2.62e-16 77.8 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,4KKXG@93682|Roseivivax 28211|Alphaproteobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation MA20_05130 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_239628_2 930166.CD58_00555 1.19e-86 267.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Radical SAM - - - - - - - - - - - - Radical_SAM k59_665366_1 983545.Glaag_2259 4.64e-61 204.0 COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,464WZ@72275|Alteromonadaceae 1236|Gammaproteobacteria C Na H antiporter nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k59_958395_1 1121121.KB894291_gene1507 1.01e-105 347.0 COG0300@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria 2|Bacteria IQ oxidoreductase activity pksR - 1.1.1.320 ko:K13611,ko:K13614,ko:K13615,ko:K16216 - - - - ko00000,ko01000,ko01004,ko01008 - - - ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,adh_short,ketoacyl-synt k59_729073_1 1049564.TevJSym_ap00560 7.9e-164 481.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1J62R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_729073_2 1454004.AW11_00862 5.36e-29 113.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,1KPUT@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_860221_1 926556.Echvi_3083 1.02e-66 228.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NDXS@976|Bacteroidetes,47YEC@768503|Cytophagia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_434981_1 324925.Ppha_2016 6.08e-37 135.0 COG0559@1|root,COG0559@2|Bacteria 2|Bacteria E leucine import across plasma membrane livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_665377_1 1177154.Y5S_02499 1e-116 349.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1XIAX@135619|Oceanospirillales 135619|Oceanospirillales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_304038_1 194439.CT0895 1.07e-89 273.0 COG0226@1|root,COG0226@2|Bacteria,1FF16@1090|Chlorobi 1090|Chlorobi P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_174954_1 1168034.FH5T_16570 1.52e-124 386.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,4NF4F@976|Bacteroidetes,2FKZU@200643|Bacteroidia 976|Bacteroidetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_958406_1 313628.LNTAR_03844 4.28e-35 134.0 COG1530@1|root,COG1530@2|Bacteria 2|Bacteria J ribonuclease E activity rng - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_632308_1 272568.GDI1662 2.45e-26 123.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein mcpX - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_632308_2 573413.Spirs_0891 6.66e-86 270.0 COG1609@1|root,COG1609@2|Bacteria 2|Bacteria K purine nucleotide biosynthetic process - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_632308_3 981383.AEWH01000024_gene2743 5.54e-258 724.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,4HA1G@91061|Bacilli 91061|Bacilli G COG0366 Glycosidases malL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.10 ko:K01182 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00801,R01718,R01791,R06199 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_860226_1 387093.SUN_2239 3.15e-164 473.0 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1MY1V@1224|Proteobacteria,42P2P@68525|delta/epsilon subdivisions 1224|Proteobacteria G phosphotransferase system, EIIB nagE GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009401,GO:0009987,GO:0015144,GO:0015764,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0033554,GO:0034219,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0090563,GO:0090586,GO:1901264 2.7.1.193 ko:K02802,ko:K02803,ko:K02804 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 - iECP_1309.ECP_0691 PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_665384_1 521460.Athe_0644 2.43e-37 141.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_174958_1 1161401.ASJA01000017_gene1300 5.04e-167 495.0 COG4206@1|root,COG4206@2|Bacteria,1QVV2@1224|Proteobacteria,2TYFS@28211|Alphaproteobacteria,44158@69657|Hyphomonadaceae 28211|Alphaproteobacteria H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_926811_2 153721.MYP_4253 1.09e-16 82.0 COG4261@1|root,COG4261@2|Bacteria,4NF49@976|Bacteroidetes,47PF5@768503|Cytophagia 976|Bacteroidetes S Bacterial lipid A biosynthesis acyltransferase - - - - - - - - - - - - Lip_A_acyltrans k59_534833_1 474922.ELA23626 1.51e-29 121.0 COG0145@1|root,KOG1939@2759|Eukaryota,38C8D@33154|Opisthokonta,3NU0K@4751|Fungi,3QPUZ@4890|Ascomycota,21JHD@147550|Sordariomycetes,1F56W@1028384|Glomerellales 4751|Fungi E Hydantoinase B/oxoprolinase - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_142764_1 572544.Ilyop_1260 1.87e-93 293.0 COG2312@1|root,COG2312@2|Bacteria 2|Bacteria S response to antibiotic - - - ko:K06880 - - - - ko00000,ko01000,ko01504 - - - Erythro_esteras k59_142764_2 469616.FMAG_01454 1.26e-82 265.0 COG0772@1|root,COG0772@2|Bacteria,379M9@32066|Fusobacteria 32066|Fusobacteria D Belongs to the SEDS family - - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_370860_1 357808.RoseRS_2738 3.31e-75 232.0 COG0491@1|root,COG0491@2|Bacteria,2G6X9@200795|Chloroflexi,3777M@32061|Chloroflexia 32061|Chloroflexia S PFAM beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k59_468657_2 1254432.SCE1572_38865 8.4e-43 157.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1R7WZ@1224|Proteobacteria,42Q3R@68525|delta/epsilon subdivisions,2WM5A@28221|Deltaproteobacteria 28221|Deltaproteobacteria KT SMART protein phosphatase 2C domain protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GAF_2,SSF,SpoIIE k59_534839_2 1268239.PALB_12530 2.6e-40 135.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,2Q2QC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J COG1544 Ribosome-associated protein Y (PSrp-1) yhbH GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_827995_1 857087.Metme_2346 3.23e-65 217.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1XEQK@135618|Methylococcales 135618|Methylococcales O Cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_827995_2 1001585.MDS_1886 3.16e-22 90.5 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria,1YFZ8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678 - ko:K02197 - - - - ko00000 - - iSSON_1240.SSON_2255 CcmE k59_632321_1 394221.Mmar10_0178 1.47e-55 193.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,43WSR@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_632321_2 589865.DaAHT2_2495 6.71e-100 311.0 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MIM9@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_860244_1 1123326.JFBL01000008_gene488 1.63e-83 251.0 COG2249@1|root,COG2249@2|Bacteria,1MWV9@1224|Proteobacteria,42T5G@68525|delta/epsilon subdivisions,2YTR3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S modulator of drug activity B - - - ko:K03923 - - - - ko00000 - - iIT341.HP0630 Flavodoxin_2 k59_502107_1 929562.Emtol_3268 6.26e-73 229.0 COG2114@1|root,COG2204@1|root,COG2114@2|Bacteria,COG2204@2|Bacteria,4NF1F@976|Bacteroidetes,47MSJ@768503|Cytophagia 976|Bacteroidetes T Adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - Guanylate_cyc,Response_reg k59_502107_2 616991.JPOO01000003_gene1950 3.87e-18 85.1 COG1284@1|root,COG1284@2|Bacteria,4NG9F@976|Bacteroidetes,1HY56@117743|Flavobacteriia,23HW4@178469|Arenibacter 976|Bacteroidetes S Uncharacterised 5xTM membrane BCR, YitT family COG1284 - - - - - - - - - - - - DUF2179,YitT_membrane k59_338933_1 1423321.AS29_08885 2.27e-23 90.1 COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,4HNJA@91061|Bacilli,1ZIX5@1386|Bacillus 91061|Bacilli S Uncharacterized conserved protein (DUF2196) ywbE - - - - - - - - - - - DUF2196 k59_338933_2 1172190.M947_11425 1.83e-34 119.0 COG2026@1|root,COG2026@2|Bacteria,1Q3BI@1224|Proteobacteria,431RR@68525|delta/epsilon subdivisions,2YSBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria DJ ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_338933_3 1172190.M947_11420 2.21e-34 119.0 COG3905@1|root,COG3905@2|Bacteria,1R0RS@1224|Proteobacteria,431G1@68525|delta/epsilon subdivisions,2YS6Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - - - - - - - - - - - k59_239670_1 1536769.P40081_25275 1.06e-26 112.0 COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,4HDFB@91061|Bacilli,26RVF@186822|Paenibacillaceae 91061|Bacilli G Alpha-L-rhamnosidase ramA - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_1023756_1 33035.JPJF01000098_gene1767 4.48e-42 152.0 COG1609@1|root,COG1609@2|Bacteria,1TSRM@1239|Firmicutes,24BFS@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_4 k59_1023756_2 347834.RHE_CH01212 5.76e-154 450.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,4B8TA@82115|Rhizobiaceae 28211|Alphaproteobacteria G Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system - - - ko:K17215 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - ABC_tran k59_142779_1 391038.Bphy_5504 6.6e-116 366.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae 28216|Betaproteobacteria V Efflux pump membrane transporter - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_893298_1 66692.ABC4121 1.56e-12 61.6 COG0230@1|root,COG0230@2|Bacteria,1VK90@1239|Firmicutes,4HR2Z@91061|Bacilli,1ZJ74@1386|Bacillus 91061|Bacilli J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 k59_893298_2 572544.Ilyop_1907 2.11e-37 129.0 COG0594@1|root,COG0594@2|Bacteria,37AC7@32066|Fusobacteria 32066|Fusobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_143373_14 402777.KB235904_gene4764 1.62e-19 93.2 COG4886@1|root,COG4886@2|Bacteria,1G0NZ@1117|Cyanobacteria,1HBAM@1150|Oscillatoriales 1117|Cyanobacteria S Leucine-rich repeat (LRR) protein - - - - - - - - - - - - - k59_304637_1 1123326.JFBL01000016_gene2498 2.31e-34 137.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2YMUQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_371419_1 1168034.FH5T_08690 1.25e-11 62.4 COG0307@1|root,COG0307@2|Bacteria,4NHI8@976|Bacteroidetes,2FNEF@200643|Bacteroidia 976|Bacteroidetes H Riboflavin synthase ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_371419_2 391616.OA238_c37940 1.24e-10 63.5 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2TR0A@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) ptr1 - - - - - - - - - - - adh_short,adh_short_C2 k59_109982_2 1217712.F971_00291 8.88e-28 102.0 2E8MC@1|root,332YU@2|Bacteria,1QMIK@1224|Proteobacteria,1TN5G@1236|Gammaproteobacteria,3NQ10@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_42667_1 269799.Gmet_0852 5.6e-74 233.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,43TNC@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_42667_2 521045.Kole_0246 2.11e-05 45.8 COG0809@1|root,COG0809@2|Bacteria,2GBXV@200918|Thermotogae 200918|Thermotogae F Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_535466_1 1243664.CAVL020000027_gene777 7.22e-82 257.0 COG3033@1|root,COG3033@2|Bacteria,1TRGV@1239|Firmicutes,4HEYP@91061|Bacilli,1ZM4F@1386|Bacillus 91061|Bacilli E Beta-eliminating lyase - - - - - - - - - - - - Beta_elim_lyase k59_304647_1 870187.Thini_0156 5.21e-63 204.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,460FC@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_793498_1 1123514.KB905899_gene733 7.06e-30 124.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,45ZUT@72273|Thiotrichales 72273|Thiotrichales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_147693_2 1288826.MSNKSG1_09333 9.03e-48 164.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,4656J@72275|Alteromonadaceae 1236|Gammaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_275518_1 1382306.JNIM01000001_gene2353 3.27e-32 130.0 2DVYA@1|root,33XPC@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_931487_1 1168034.FH5T_13000 8.24e-75 229.0 COG0664@1|root,COG0664@2|Bacteria,4NKXQ@976|Bacteroidetes 976|Bacteroidetes T cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding k59_931487_2 929703.KE386491_gene4038 0.000101 45.1 COG2353@1|root,COG2353@2|Bacteria,4NMWH@976|Bacteroidetes,47PZ0@768503|Cytophagia 976|Bacteroidetes S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_113896_1 563040.Saut_1533 6.66e-37 129.0 2AK0W@1|root,31AQE@2|Bacteria,1Q5YN@1224|Proteobacteria,42VDB@68525|delta/epsilon subdivisions,2YQDT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_733658_1 1123279.ATUS01000001_gene2294 9.09e-07 52.8 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1J6FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S SURF1-like protein surf1 - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_733658_2 1335757.SPICUR_01600 2.38e-15 70.5 2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2909) VL23_10685 - - - - - - - - - - - DUF2909 k59_733658_3 666685.R2APBS1_0278 2.48e-45 154.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1X3ZT@135614|Xanthomonadales 135614|Xanthomonadales C Heme copper-type cytochrome quinol oxidase subunit 3 cox3 - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_472834_1 1120999.JONM01000005_gene3779 6.84e-34 135.0 COG0515@1|root,COG3899@1|root,COG5002@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - AAA_16,CHASE,GAF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Pkinase,Response_reg,SBP_bac_3 k59_507582_1 748247.AZKH_p0015 0.000217 48.5 COG0583@1|root,COG0583@2|Bacteria,1R8ZM@1224|Proteobacteria,2VNX1@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_407611_1 1033802.SSPSH_003347 9.87e-85 262.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_996809_1 1122603.ATVI01000006_gene541 6.29e-86 263.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1X45U@135614|Xanthomonadales 135614|Xanthomonadales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_996809_2 713587.THITH_15585 1.69e-20 86.7 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_733673_1 1333998.M2A_0166 1.07e-34 134.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,4BTBE@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria CG PQQ enzyme repeat - - 1.1.9.1 ko:K17760 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_507595_1 1168034.FH5T_04030 8.94e-111 328.0 COG0547@1|root,COG0547@2|Bacteria,4NH2J@976|Bacteroidetes,2FPE1@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_180233_1 205922.Pfl01_2004 1.05e-23 103.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_309097_1 1157708.KB907452_gene4028 9.95e-49 171.0 COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2VII8@28216|Betaproteobacteria,4AC8U@80864|Comamonadaceae 28216|Betaproteobacteria G Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor otsA - 2.4.1.15,2.4.1.213,2.4.1.347 ko:K00697,ko:K03692 ko00500,ko01100,map00500,map01100 - R02737 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20 k59_275533_1 1499967.BAYZ01000009_gene5239 3.98e-27 115.0 COG2203@1|root,COG4251@1|root,COG2203@2|Bacteria,COG4251@2|Bacteria,2NPB3@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - CHASE3,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,RsbRD_N k59_439859_1 375451.RD1_2873 6.02e-39 146.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2TT73@28211|Alphaproteobacteria,2P2GI@2433|Roseobacter 28211|Alphaproteobacteria F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_931516_1 397291.C804_04234 3.23e-09 62.0 COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia 186801|Clostridia M RHS repeat-associated core domain - - - - - - - - - - - - RHS_repeat k59_212659_1 1298858.AUEL01000029_gene99 2.24e-15 77.0 COG3179@1|root,COG3179@2|Bacteria,1R71F@1224|Proteobacteria,2UD1N@28211|Alphaproteobacteria,43MAV@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S chitinase - - - - - - - - - - - - Glyco_hydro_19 k59_670371_2 120017.I2G5A0 0.000472 45.8 COG0526@1|root,KOG0910@2759|Eukaryota,3A8MT@33154|Opisthokonta,3P7ZQ@4751|Fungi,3V27P@5204|Basidiomycota,3N1FT@452284|Ustilaginomycotina 4751|Fungi O Thioredoxin-like domain - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_80903_2 1265505.ATUG01000001_gene4718 8.43e-59 202.0 COG1629@1|root,COG4771@2|Bacteria,1RE7S@1224|Proteobacteria,42RTR@68525|delta/epsilon subdivisions,2WNM8@28221|Deltaproteobacteria 28221|Deltaproteobacteria M TonB-dependent Receptor Plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_439871_2 1297569.MESS2_670009 1.45e-85 253.0 COG1943@1|root,COG1943@2|Bacteria,1RF1K@1224|Proteobacteria,2U886@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_733705_1 709032.Sulku_0238 2.01e-122 355.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,42NX7@68525|delta/epsilon subdivisions,2YMKE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar biosynthetic protein fliR fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_733705_2 944547.ABLL_0661 0.000177 43.1 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42PQP@68525|delta/epsilon subdivisions,2YNQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein ybbA - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_931532_1 83219.PM02_18920 1.12e-13 67.4 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,3ZXIA@60136|Sulfitobacter 28211|Alphaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_931532_2 243233.MCA1042 3.18e-09 57.8 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,1SASG@1236|Gammaproteobacteria,1XFDH@135618|Methylococcales 135618|Methylococcales O Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,Redoxin k59_244296_1 794903.OPIT5_18260 8.49e-06 48.9 COG0598@1|root,COG0598@2|Bacteria,46VYH@74201|Verrucomicrobia,3K7J8@414999|Opitutae 414999|Opitutae P CorA-like Mg2+ transporter protein corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_996836_1 1713.JOFV01000002_gene502 2.34e-98 305.0 COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4F11S@85016|Cellulomonadaceae 201174|Actinobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_733715_1 240016.ABIZ01000001_gene1668 6.78e-58 192.0 COG3239@1|root,COG3239@2|Bacteria,46SX7@74201|Verrucomicrobia 74201|Verrucomicrobia I Fatty acid desaturase desA - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_832845_1 1408433.JHXV01000020_gene3528 1.49e-82 263.0 COG0422@1|root,COG0422@2|Bacteria,4NFTF@976|Bacteroidetes,1HZ6B@117743|Flavobacteriia,2PBAB@246874|Cryomorphaceae 976|Bacteroidetes H ThiC-associated domain thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_767442_1 765911.Thivi_2766 4.98e-103 327.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_244303_1 1120985.AUMI01000015_gene1683 4.25e-06 51.6 COG3190@1|root,COG3190@2|Bacteria,1V9E3@1239|Firmicutes,4H4YD@909932|Negativicutes 909932|Negativicutes N Flagellar biosynthesis protein, FliO fliO - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO k59_244303_2 526222.Desal_3815 9.5e-14 69.3 COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,42TQB@68525|delta/epsilon subdivisions,2WQCQ@28221|Deltaproteobacteria,2MB3C@213115|Desulfovibrionales 28221|Deltaproteobacteria N PFAM surface presentation of antigens (SPOA) protein fliN - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C k59_604907_1 326298.Suden_0859 1.64e-155 452.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2YMMM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_604907_2 563040.Saut_0906 1.66e-22 95.9 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2YMKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_767448_1 1049564.TevJSym_aa00370 3.51e-74 245.0 COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1J5G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon2 - 3.4.21.53 ko:K01338,ko:K08675 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002,ko03029 - - - AAA,LON_substr_bdg,Lon_C k59_796715_1 572544.Ilyop_1863 1.32e-146 425.0 COG1840@1|root,COG1840@2|Bacteria,3791X@32066|Fusobacteria 32066|Fusobacteria P Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF1858,SBP_bac_6 k59_796715_2 1216362.B437_03196 4.88e-29 112.0 COG0664@1|root,COG0664@2|Bacteria,379VY@32066|Fusobacteria 32066|Fusobacteria K Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_473532_1 1168034.FH5T_18995 6.61e-124 358.0 COG1266@1|root,COG1266@2|Bacteria,4NMMK@976|Bacteroidetes,2FP40@200643|Bacteroidia 976|Bacteroidetes S CAAX amino terminal protease family sagE - - ko:K07052 - - - - ko00000 - - - Abi k59_540461_1 439235.Dalk_2058 2.89e-28 109.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42UBZ@68525|delta/epsilon subdivisions,2WNB6@28221|Deltaproteobacteria,2MJXY@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM Sua5 YciO YrdC YwlC family protein - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_540461_2 1121405.dsmv_3672 1.78e-19 88.2 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MIPF@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - AIRC,GARS_A,GARS_C,GARS_N k59_440570_1 439235.Dalk_1106 4.25e-26 110.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,42NJB@68525|delta/epsilon subdivisions,2WM62@28221|Deltaproteobacteria,2MI1G@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2333) - - - - - - - - - - - - DUF2333 k59_473543_1 1191523.MROS_2338 1.02e-58 196.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase ydjG GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0019170,GO:0055114 - ko:K18471 ko00640,map00640 - R10718 RC00739 ko00000,ko00001,ko01000 - - - Aldo_ket_red k59_899008_1 1190606.AJYG01000006_gene2355 7.67e-77 244.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XUVI@135623|Vibrionales 135623|Vibrionales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_638041_1 857087.Metme_4126 2.8e-57 188.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1XDMX@135618|Methylococcales 135618|Methylococcales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_638041_2 105559.Nwat_3092 1.77e-29 115.0 COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SWXH@1236|Gammaproteobacteria,1X1CE@135613|Chromatiales 135613|Chromatiales S signal sequence binding - - - - - - - - - - - - - k59_572478_1 1116472.MGMO_84c00070 4.44e-76 236.0 COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales 135618|Methylococcales D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 k59_572478_2 1049564.TevJSym_ac01700 5.92e-05 46.2 COG5607@1|root,COG5607@2|Bacteria,1R5I1@1224|Proteobacteria,1S0QK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T pfam chad - - - - - - - - - - - - CHAD,His_Phos_1 k59_1029077_1 313595.P700755_002781 3.48e-106 331.0 COG3385@1|root,COG3385@2|Bacteria,4NKTU@976|Bacteroidetes,1I7NH@117743|Flavobacteriia 976|Bacteroidetes L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_180966_1 1168034.FH5T_12095 6.33e-92 289.0 COG0317@1|root,COG0317@2|Bacteria,4NESY@976|Bacteroidetes,2FMEE@200643|Bacteroidia 976|Bacteroidetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_899011_1 1165841.SULAR_07655 2.81e-47 167.0 COG0642@1|root,COG0642@2|Bacteria,1RGPU@1224|Proteobacteria,42RPY@68525|delta/epsilon subdivisions,2YPD9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_932218_1 827.JFJK01000014_gene627 3.11e-18 91.7 COG0642@1|root,COG0642@2|Bacteria,1N5IQ@1224|Proteobacteria,42M9P@68525|delta/epsilon subdivisions,2YN0U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase cprS - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_671120_1 1408473.JHXO01000011_gene3037 1.79e-80 249.0 COG1579@1|root,COG1579@2|Bacteria,4NE36@976|Bacteroidetes,2FPGP@200643|Bacteroidia 976|Bacteroidetes S Zinc ribbon domain protein - - - ko:K07164 - - - - ko00000 - - - zf-RING_7 k59_47246_2 563040.Saut_0369 4.38e-88 268.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,42ME7@68525|delta/epsilon subdivisions,2YMBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG membrane - - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA k59_376099_1 1234364.AMSF01000021_gene1264 2.93e-18 83.6 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1X4AQ@135614|Xanthomonadales 135614|Xanthomonadales M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_376099_2 187272.Mlg_0922 4.16e-54 175.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1WYD7@135613|Chromatiales 135613|Chromatiales O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_276289_1 880073.Calab_3467 1.94e-49 177.0 COG0708@1|root,COG4886@1|root,COG0708@2|Bacteria,COG4886@2|Bacteria 2|Bacteria S regulation of response to stimulus - - 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH13 - DUF3160,Flg_new,LRR_5 k59_245046_1 1382359.JIAL01000001_gene2799 3.44e-15 75.5 COG0673@1|root,COG0673@2|Bacteria,3Y3V4@57723|Acidobacteria,2JI4A@204432|Acidobacteriia 204432|Acidobacteriia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_245046_2 1210884.HG799472_gene14911 7e-09 57.8 COG1520@1|root,COG1520@2|Bacteria,2IWXJ@203682|Planctomycetes 203682|Planctomycetes S PQQ-like domain - - - - - - - - - - - - PQQ_2 k59_899041_1 435590.BVU_1151 6.2e-88 283.0 COG3250@1|root,COG3250@2|Bacteria,4NGZD@976|Bacteroidetes,2G08E@200643|Bacteroidia,4ANAP@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Glyco_hydro_43 k59_865765_2 749222.Nitsa_1227 1.68e-21 96.3 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,42MUY@68525|delta/epsilon subdivisions,2YMZF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E PFAM peptidase M3A and M3B thimet oligopeptidase F prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_833606_1 572480.Arnit_0649 3.41e-61 203.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2YMGU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H tRNA nucleotidyltransferase poly(A) polymerase cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_540521_1 1168034.FH5T_15385 1.57e-55 193.0 COG3291@1|root,COG3291@2|Bacteria,4P9ST@976|Bacteroidetes,2G02B@200643|Bacteroidia 976|Bacteroidetes S C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,PKD k59_508293_1 1168034.FH5T_13065 8.44e-24 107.0 COG0457@1|root,COG0457@2|Bacteria,4NGGZ@976|Bacteroidetes,2FMHN@200643|Bacteroidia 976|Bacteroidetes S tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8 k59_797441_1 83406.HDN1F_29010 8.02e-129 406.0 COG0433@1|root,COG0433@2|Bacteria,1NAXG@1224|Proteobacteria,1SJQR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 3'(2'),5'-bisphosphate nucleotidase activity - - - - - - - - - - - - Inovirus_Gp2 k59_865766_1 1121267.JHZL01000008_gene1339 1.41e-16 79.3 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,42NKR@68525|delta/epsilon subdivisions,2YMU1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_997625_1 95619.PM1_0218550 2.88e-25 102.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_213412_1 935567.JAES01000005_gene535 1.3e-43 162.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1X3A5@135614|Xanthomonadales 135614|Xanthomonadales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_703034_2 945713.IALB_1660 2.11e-70 218.0 COG2391@1|root,COG2391@2|Bacteria 2|Bacteria - - - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_703034_3 404589.Anae109_4106 1.92e-52 178.0 COG3301@1|root,COG3301@2|Bacteria,1MXQ9@1224|Proteobacteria,42NE8@68525|delta/epsilon subdivisions,2WSJ7@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_81751_1 387092.NIS_0130 4.08e-97 293.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,42MYW@68525|delta/epsilon subdivisions,2YN5Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_81751_2 929558.SMGD1_1278 1.65e-29 105.0 COG0828@1|root,COG0828@2|Bacteria,1Q61C@1224|Proteobacteria,42VSR@68525|delta/epsilon subdivisions,2YQAH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_932254_1 1408473.JHXO01000005_gene1710 1.96e-101 308.0 COG1004@1|root,COG1004@2|Bacteria,4NE00@976|Bacteroidetes,2FMZ9@200643|Bacteroidia 976|Bacteroidetes M Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_703037_1 1049564.TevJSym_bo00190 1.02e-54 194.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT,EB_dh k59_376122_1 1121445.ATUZ01000011_gene662 1.21e-27 107.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42R8B@68525|delta/epsilon subdivisions,2X5KI@28221|Deltaproteobacteria,2MGSH@213115|Desulfovibrionales 28221|Deltaproteobacteria L Endonuclease/Exonuclease/phosphatase family xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_997641_1 471870.BACINT_02960 0.000177 48.1 COG3193@1|root,COG3193@2|Bacteria,4NENU@976|Bacteroidetes,2G04D@200643|Bacteroidia 976|Bacteroidetes S Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_644248_2 1123237.Salmuc_01947 1.73e-31 117.0 COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VG6E@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator, AsnC family MA20_17015 - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_154510_1 158190.SpiGrapes_0172 4.81e-61 211.0 COG4666@1|root,COG4666@2|Bacteria,2J57Z@203691|Spirochaetes 203691|Spirochaetes S TIGRFAM TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DctM k59_546147_1 929558.SMGD1_2205 1.38e-76 253.0 COG0457@1|root,COG2843@1|root,COG0457@2|Bacteria,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42T4H@68525|delta/epsilon subdivisions,2YTQ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - - - - - - - - - - PGA_cap k59_1003825_1 572544.Ilyop_0529 2.45e-102 305.0 COG1161@1|root,COG1161@2|Bacteria,378AK@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 yqeH - - ko:K06948 - - - - ko00000,ko03009 - - - MMR_HSR1 k59_382194_1 471870.BACINT_02468 3.99e-11 62.0 COG2253@1|root,COG2253@2|Bacteria,4NPW4@976|Bacteroidetes,2FSGR@200643|Bacteroidia,4AQ55@815|Bacteroidaceae 976|Bacteroidetes S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_382194_2 483216.BACEGG_02485 6.59e-27 102.0 2DPBF@1|root,331D6@2|Bacteria,4NV6I@976|Bacteroidetes,2FU2U@200643|Bacteroidia,4AS1M@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_578581_2 1227454.C446_09333 4.25e-56 188.0 COG1575@1|root,arCOG00480@2157|Archaea,2XT1M@28890|Euryarchaeota,23TNU@183963|Halobacteria 183963|Halobacteria H Belongs to the MenA family. Type 1 subfamily menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_479784_1 1033740.CAEW01000008_gene1961 1.03e-138 425.0 COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,4H9WA@91061|Bacilli,26DRP@186818|Planococcaceae 91061|Bacilli D Belongs to the FtsK SpoIIIE SftA family ftsK GO:0000003,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019954,GO:0030436,GO:0031323,GO:0031326,GO:0032502,GO:0043934,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_187109_1 1537915.JU57_07835 1.58e-07 60.1 COG3307@1|root,COG3307@2|Bacteria 2|Bacteria M -O-antigen - - - ko:K02847,ko:K13009 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 - - Wzy_C k59_546158_1 1175654.A0A0S0NAI6_9CAUD 6.75e-46 164.0 4QG8X@10239|Viruses,4QVDN@35237|dsDNA viruses no RNA stage,4QSBT@28883|Caudovirales,4QM55@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_88017_1 1232410.KI421418_gene2422 5.9e-28 111.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,43VZ4@69541|Desulfuromonadales 28221|Deltaproteobacteria O SelR domain msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_774318_2 300852.55771925 6.64e-22 94.7 COG0423@1|root,COG0423@2|Bacteria,1WIB2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_446736_1 765912.Thimo_3284 1.67e-17 80.9 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales 135613|Chromatiales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_446736_2 1049564.TevJSym_bp00160 8.59e-86 265.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1J5CN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG4992 Ornithine acetylornithine aminotransferase argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_17612_1 439235.Dalk_2252 2.13e-96 296.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42NQT@68525|delta/epsilon subdivisions,2WJKD@28221|Deltaproteobacteria,2MJB8@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM sodium sulfate symporter - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_938371_1 1345695.CLSA_c07390 2.67e-31 125.0 COG2199@1|root,COG4564@1|root,COG3706@2|Bacteria,COG4564@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,36E8P@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - AAA_16,GGDEF,Pkinase,TPR_12,TPR_8 k59_677563_1 1007105.PT7_1562 0.000238 43.1 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,3T3UB@506|Alcaligenaceae 28216|Betaproteobacteria D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_677563_2 713586.KB900536_gene1092 4.4e-50 173.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales 135613|Chromatiales J TIGRFAM ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_17613_1 452637.Oter_1462 5.8e-16 77.8 COG0607@1|root,COG2391@1|root,COG0607@2|Bacteria,COG2391@2|Bacteria 2|Bacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - 2.8.1.1,2.8.1.2 ko:K00406,ko:K01011,ko:K07112 ko00190,ko00270,ko00920,ko01100,ko01120,ko02020,ko04122,map00190,map00270,map00920,map01100,map01120,map02020,map04122 M00156 R01931,R03105,R03106 RC00214 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - PALP,Rhodanese,Sulf_transp k59_17613_2 945713.IALB_1658 2.12e-32 121.0 COG0607@1|root,COG0607@2|Bacteria 2|Bacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS cdr2 - - - - - - - - - - - Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese k59_578604_2 631362.Thi970DRAFT_04794 2.22e-25 97.8 COG1343@1|root,COG1343@2|Bacteria,1MZ9Q@1224|Proteobacteria,1S93C@1236|Gammaproteobacteria,1WZ1W@135613|Chromatiales 135613|Chromatiales L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 k59_578604_3 269799.Gmet_1072 3.26e-57 188.0 COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,42NHJ@68525|delta/epsilon subdivisions,2WJ13@28221|Deltaproteobacteria 28221|Deltaproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k59_446740_1 1122951.ATUE01000011_gene505 2.36e-21 86.7 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,3NNHP@468|Moraxellaceae 1236|Gammaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_446740_2 768066.HELO_1237 1.26e-51 168.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1XH61@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_154542_1 326298.Suden_0274 4.9e-58 189.0 COG0348@1|root,COG0348@2|Bacteria,1Q4BA@1224|Proteobacteria,42Q02@68525|delta/epsilon subdivisions 1224|Proteobacteria C 4Fe-4S ferredoxin - - - - - - - - - - - - Fer4_10,Fer4_5,Fer4_9 k59_154542_2 1172190.M947_03110 1.09e-28 113.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42PEQ@68525|delta/epsilon subdivisions,2YN97@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E 2-hydroxyglutaryl-CoA dehydratase hgdD - - - - - - - - - - - HGD-D k59_740633_2 1122194.AUHU01000004_gene1371 3.5e-30 116.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,468TM@72275|Alteromonadaceae 1236|Gammaproteobacteria F Glutamine amidotransferase class-I guaA_2 - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_514577_1 2340.JV46_17580 2.25e-57 192.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_282414_1 1353537.TP2_06855 2.16e-50 169.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2TTI4@28211|Alphaproteobacteria,2XMRJ@285107|Thioclava 28211|Alphaproteobacteria S Displays ATPase and GTPase activities yvcJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_446760_1 929558.SMGD1_0631 4.25e-48 159.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42PA1@68525|delta/epsilon subdivisions,2YNMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_446760_2 929558.SMGD1_1611 1.93e-67 210.0 COG0704@1|root,COG0704@2|Bacteria,1Q5TJ@1224|Proteobacteria,42STN@68525|delta/epsilon subdivisions,2YPRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P PhoU family - - - ko:K02039 - - - - ko00000 - - - PhoU k59_839736_1 926550.CLDAP_05110 2.71e-14 72.0 COG0356@1|root,COG0356@2|Bacteria,2G6NF@200795|Chloroflexi 200795|Chloroflexi C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_839736_2 714961.BFZC1_18315 4.56e-08 52.4 COG0636@1|root,COG0636@2|Bacteria,1VEHP@1239|Firmicutes,4HNKQ@91061|Bacilli,3IYFM@400634|Lysinibacillus 91061|Bacilli C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_740635_1 1196835.A458_07780 2.93e-127 378.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RRVF@1236|Gammaproteobacteria,1Z2NC@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria V Type I restriction-modification system hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_514584_1 768671.ThimaDRAFT_0909 5.63e-116 340.0 COG1131@1|root,COG1131@2|Bacteria,1R3XF@1224|Proteobacteria,1S0MM@1236|Gammaproteobacteria 1236|Gammaproteobacteria V abc transporter atp-binding protein nodI - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_315934_1 278957.ABEA03000046_gene1625 2.19e-66 215.0 COG3550@1|root,COG3550@2|Bacteria,46XT4@74201|Verrucomicrobia,3K8Y8@414999|Opitutae 414999|Opitutae S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_187155_2 1167006.UWK_00855 1.89e-109 336.0 2CDM0@1|root,33HR7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1003890_1 2340.JV46_13030 1.27e-79 244.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1003890_2 2340.JV46_13040 1.86e-07 52.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J85H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_282436_2 765912.Thimo_0182 6.77e-33 117.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1WY9Z@135613|Chromatiales 135613|Chromatiales I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA - - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_611682_1 1157490.EL26_07685 1.42e-14 75.9 COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,278G9@186823|Alicyclobacillaceae 91061|Bacilli O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_315955_1 349124.Hhal_2027 1.14e-70 236.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_871908_1 397945.Aave_0778 0.000644 43.9 2E54A@1|root,32ZX9@2|Bacteria,1N8HJ@1224|Proteobacteria,2VVW9@28216|Betaproteobacteria,4AFMV@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1840) - - - - - - - - - - - - DUF1840 k59_546231_1 990073.ATHU01000001_gene1757 2.5e-57 194.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,42MWR@68525|delta/epsilon subdivisions,2YNCN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C TIGRFAM SagB-type dehydrogenase domain - - - - - - - - - - - - Nitroreductase k59_546231_2 709032.Sulku_1312 2.45e-10 60.8 COG0666@1|root,COG0666@2|Bacteria,1Q4NQ@1224|Proteobacteria,42VS5@68525|delta/epsilon subdivisions,2YQIE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ankyrin repeat - - - - - - - - - - - - Ank_4 k59_17693_1 682795.AciX8_3032 1.23e-12 70.9 COG3710@1|root,COG5616@1|root,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7Y2@57723|Acidobacteria,2JMY7@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator - - - - - - - - - - - - Trans_reg_C k59_315959_1 387093.SUN_1872 1.56e-124 372.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2YMRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_446799_1 582899.Hden_0690 2.62e-97 295.0 COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_479851_1 1049564.TevJSym_ad00780 7.12e-66 217.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1035012_1 1235803.C825_02167 1.35e-13 69.3 COG0703@1|root,COG0703@2|Bacteria,4NQ73@976|Bacteroidetes,2FM3K@200643|Bacteroidia,22Y40@171551|Porphyromonadaceae 976|Bacteroidetes F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_1035012_2 1231190.NA8A_11143 1.63e-36 136.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,43NCE@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_871919_1 929558.SMGD1_0709 7.43e-52 181.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2YMRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_871919_2 70601.3257654 6.78e-31 122.0 COG0614@1|root,arCOG03303@2157|Archaea,2XVSW@28890|Euryarchaeota,24321@183968|Thermococci 183968|Thermococci P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_803707_1 95619.PM1_0217305 7.67e-55 184.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188 DXPR_C,DXP_redisom_C,DXP_reductoisom k59_803707_2 870187.Thini_3970 2.18e-14 72.4 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,460AB@72273|Thiotrichales 72273|Thiotrichales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_905397_1 933262.AXAM01000093_gene1585 2.94e-50 174.0 COG2070@1|root,COG2070@2|Bacteria,1MWMI@1224|Proteobacteria,42P2I@68525|delta/epsilon subdivisions,2WK0M@28221|Deltaproteobacteria,2MIJJ@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM PfaD family protein - - - - - - - - - - - - NMO k59_905397_2 405948.SACE_0021 2.88e-21 93.6 COG0236@1|root,COG3321@1|root,COG0236@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4DZDB@85010|Pseudonocardiales 201174|Actinobacteria Q polyketide synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_709218_1 1168034.FH5T_20545 9.93e-71 229.0 COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,2FX28@200643|Bacteroidia 976|Bacteroidetes I Acetyl-coenzyme A synthetase N-terminus acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_219666_1 1168034.FH5T_14985 1.85e-68 218.0 COG2972@1|root,COG2972@2|Bacteria,4NK09@976|Bacteroidetes,2FNWE@200643|Bacteroidia 976|Bacteroidetes T Histidine kinase ypdA_4 - - - - - - - - - - - HATPase_c_5,His_kinase k59_611695_1 398720.MED217_01350 2.23e-136 400.0 COG3664@1|root,COG3664@2|Bacteria,4NHQ0@976|Bacteroidetes,1I5WJ@117743|Flavobacteriia,2XJXS@283735|Leeuwenhoekiella 976|Bacteroidetes G Glycosyl hydrolases family 39 - - 3.2.1.37 ko:K01198 ko00520,ko01100,map00520,map01100 - R01433 RC00467 ko00000,ko00001,ko01000 - GH43 - Glyco_hydro_39 k59_155223_2 1121481.AUAS01000009_gene78 1.03e-36 138.0 COG1554@1|root,COG1554@2|Bacteria,4NHVP@976|Bacteroidetes,47M58@768503|Cytophagia 976|Bacteroidetes G hydrolase, family 65, central catalytic - - - - - - - - - - - - - k59_515171_1 1158345.JNLL01000001_gene1440 2.05e-09 61.6 COG0457@1|root,COG0457@2|Bacteria,2G407@200783|Aquificae 200783|Aquificae NU Tetratricopeptide repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_515171_2 1121875.KB907548_gene1606 5.08e-26 103.0 28KF8@1|root,2ZA1G@2|Bacteria,4NK7X@976|Bacteroidetes,1I0C7@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1004405_1 1217718.ALOU01000002_gene4713 6.18e-59 201.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,1K0VC@119060|Burkholderiaceae 28216|Betaproteobacteria V abc transporter atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_709817_1 387093.SUN_1659 2.13e-45 164.0 COG0068@1|root,COG0068@2|Bacteria,1Q0S6@1224|Proteobacteria,42SF1@68525|delta/epsilon subdivisions,2YPJ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O HypF finger - - - - - - - - - - - - zf-HYPF k59_1004406_1 443144.GM21_2039 8.43e-49 164.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_18219_1 1341151.ASZU01000004_gene120 5.45e-12 70.5 COG1752@1|root,COG1752@2|Bacteria,1UUVB@1239|Firmicutes,4HDFQ@91061|Bacilli,27BBT@186824|Thermoactinomycetaceae 91061|Bacilli S Patatin-like phospholipase ylbK GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_741221_1 1200567.JNKD01000069_gene228 1.75e-60 197.0 COG3680@1|root,COG3680@2|Bacteria,1R7PZ@1224|Proteobacteria,1T0YY@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures - - - ko:K09968 - - - - ko00000 - - - - k59_155238_1 1347392.CCEZ01000013_gene2629 4.66e-169 489.0 COG4146@1|root,COG4146@2|Bacteria,1UHPR@1239|Firmicutes,24QXT@186801|Clostridia,36FAM@31979|Clostridiaceae 186801|Clostridia S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_774975_1 1321781.HMPREF1985_02032 3.67e-30 124.0 COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,4H22V@909932|Negativicutes 909932|Negativicutes L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_579073_1 1168034.FH5T_00390 1.88e-108 325.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,4NDXQ@976|Bacteroidetes,2FMKX@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_905945_1 768671.ThimaDRAFT_4882 2.88e-69 221.0 COG3385@1|root,COG3385@2|Bacteria,1N963@1224|Proteobacteria,1SE1N@1236|Gammaproteobacteria,1WZEW@135613|Chromatiales 135613|Chromatiales L transposase activity - - - - - - - - - - - - DDE_5 k59_546869_1 1168034.FH5T_12470 3.14e-122 375.0 COG0770@1|root,COG0787@1|root,COG0770@2|Bacteria,COG0787@2|Bacteria,4NEXM@976|Bacteroidetes,2FMM3@200643|Bacteroidia 976|Bacteroidetes M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1,6.3.2.10 ko:K01775,ko:K01929 ko00300,ko00473,ko00550,ko01100,ko01502,map00300,map00473,map00550,map01100,map01502 - R00401,R04573,R04617 RC00064,RC00141,RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N,Mur_ligase,Mur_ligase_M k59_938889_1 1191460.F959_01634 3.75e-30 119.0 COG0323@1|root,COG0323@2|Bacteria,1PZFG@1224|Proteobacteria,1RSZK@1236|Gammaproteobacteria,3NS05@468|Moraxellaceae 1236|Gammaproteobacteria L Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c_3 k59_351453_2 990073.ATHU01000001_gene1211 3.58e-47 157.0 COG1051@1|root,COG1051@2|Bacteria,1QUM0@1224|Proteobacteria,42SY6@68525|delta/epsilon subdivisions,2YPEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F ADP-ribose pyrophosphatase - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_612339_1 1172190.M947_01860 2.1e-234 662.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,42N42@68525|delta/epsilon subdivisions,2YMNR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_709827_2 709032.Sulku_2665 3.93e-63 207.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,42R8A@68525|delta/epsilon subdivisions,2YNBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Secretion protein, HlyD - - - ko:K01993,ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_774981_3 1537917.JU82_08175 6.26e-89 269.0 COG0500@1|root,COG2226@2|Bacteria,1NV27@1224|Proteobacteria,42P39@68525|delta/epsilon subdivisions,2YNRW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_31 k59_160513_1 1168034.FH5T_18820 3.43e-149 450.0 COG2887@1|root,COG2887@2|Bacteria,4NFZQ@976|Bacteroidetes,2FN03@200643|Bacteroidia 976|Bacteroidetes L DNA-dependent ATPase I and helicase II - - - - - - - - - - - - PDDEXK_1 k59_520108_1 1150621.SMUL_2453 3.65e-60 199.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2YMPK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1040878_1 1415779.JOMH01000001_gene209 1.38e-121 356.0 COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,1RP4C@1236|Gammaproteobacteria,1X3HD@135614|Xanthomonadales 135614|Xanthomonadales S Alpha beta hydrolase dhaA - - ko:K22318 - - - - ko00000 - - - Abhydrolase_1 k59_22920_1 1499686.BN1079_02112 1.22e-26 105.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_22920_2 1177181.T9A_02366 1.49e-22 87.4 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1XMCR@135619|Oceanospirillales 135619|Oceanospirillales J there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_22920_3 247634.GPB2148_721 3.05e-33 116.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,1J6PJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_22920_4 472759.Nhal_3902 4.34e-48 159.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales 135613|Chromatiales L Belongs to the UPF0758 family - - - ko:K03630 - - - - ko00000 - - - RadC k59_520115_1 1123400.KB904749_gene720 6.06e-30 121.0 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_287939_1 1249627.D779_2841 1.42e-45 155.0 COG3301@1|root,COG3301@2|Bacteria,1MXQ9@1224|Proteobacteria,1RQIT@1236|Gammaproteobacteria,1WZM1@135613|Chromatiales 135613|Chromatiales P Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_287939_2 572477.Alvin_1320 2.39e-28 108.0 COG3381@1|root,COG3381@2|Bacteria,1N1T1@1224|Proteobacteria,1S9X5@1236|Gammaproteobacteria,1WZAE@135613|Chromatiales 135613|Chromatiales S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_1008603_1 1168034.FH5T_18985 4.23e-77 252.0 COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,2FNBG@200643|Bacteroidia 976|Bacteroidetes M transglycosylase ponA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_682517_1 1265313.HRUBRA_01388 1.61e-25 104.0 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1J4U0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008 - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_682517_2 59196.RICGR_0966 1.04e-09 58.5 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1JD0I@118969|Legionellales 118969|Legionellales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_419224_1 999141.GME_04107 2.14e-52 176.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1XHGU@135619|Oceanospirillales 135619|Oceanospirillales S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_552696_1 1121935.AQXX01000084_gene5360 6.88e-50 169.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1XIAF@135619|Oceanospirillales 135619|Oceanospirillales M Cyclopropane fatty acid synthase and related - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_649846_1 314345.SPV1_11656 7.76e-43 148.0 COG2515@1|root,COG2515@2|Bacteria,1R87T@1224|Proteobacteria 1224|Proteobacteria E 1-aminocyclopropane-1-carboxylate deaminase acd - 3.5.99.7 ko:K01505 ko00270,map00270 - R00997 RC00419 ko00000,ko00001,ko01000 - - - PALP k59_649846_2 553220.CAMGR0001_1047 1.11e-20 90.1 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,43B2E@68525|delta/epsilon subdivisions,2YN33@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M peptidylprolyl isomerase peb4 - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_453735_1 383372.Rcas_2039 2.9e-61 201.0 COG2021@1|root,COG2021@2|Bacteria,2G5JD@200795|Chloroflexi,374TP@32061|Chloroflexia 32061|Chloroflexia E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1041343_1 1123366.TH3_11850 2.76e-97 300.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,2JW49@204441|Rhodospirillales 204441|Rhodospirillales S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_745879_1 987059.RBXJA2T_03379 4.43e-06 52.4 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,2VJAG@28216|Betaproteobacteria,1KN4P@119065|unclassified Burkholderiales 28216|Betaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_288430_1 925775.XVE_4537 1.71e-49 179.0 COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,1RMSV@1236|Gammaproteobacteria,1X31I@135614|Xanthomonadales 135614|Xanthomonadales E peptidase ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_808983_1 459495.SPLC1_S360500 3.73e-110 325.0 COG0179@1|root,COG0179@2|Bacteria,1G06Y@1117|Cyanobacteria,1H915@1150|Oscillatoriales 1117|Cyanobacteria Q COGs COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway) hpcE - - - - - - - - - - - DUF2437,FAA_hydrolase k59_617682_1 1209989.TepiRe1_0983 1.88e-10 60.1 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,42F7H@68295|Thermoanaerobacterales 186801|Clostridia S pfam abc - - - ko:K06158,ko:K19350 ko02010,map02010 - - - ko00000,ko00001,ko01504,ko02000,ko03012 3.A.1.121 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_617682_2 1123315.AUIP01000004_gene1293 1.22e-93 276.0 COG1961@1|root,COG1961@2|Bacteria,1TPBH@1239|Firmicutes,4HXG1@91061|Bacilli 91061|Bacilli L resolvase - - - - - - - - - - - - - k59_808990_1 1158165.KB898871_gene2109 7.43e-51 174.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M heptosyltransferase opsX - - ko:K12982 - - - - ko00000,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_356264_1 580332.Slit_2777 1.51e-123 369.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria 28216|Betaproteobacteria O serine protease nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_225316_1 387093.SUN_1087 3.91e-184 523.0 COG0145@1|root,COG0145@2|Bacteria,1NRJS@1224|Proteobacteria,42PZS@68525|delta/epsilon subdivisions,2YNEM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EQ MutL protein - - - - - - - - - - - - MutL k59_975831_2 1123326.JFBL01000001_gene1333 2.11e-92 282.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,42M5T@68525|delta/epsilon subdivisions,2YNN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cofactor biosynthesis protein NifE - - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_1041364_1 880073.Calab_0109 2.74e-41 151.0 COG3829@1|root,COG3829@2|Bacteria 2|Bacteria T transcription factor binding - - - - - - - - - - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_808998_2 765420.OSCT_1559 6.11e-22 95.1 COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi,375JF@32061|Chloroflexia 32061|Chloroflexia K PFAM sigma-70 region 2 domain protein - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_910601_1 1168034.FH5T_07035 1.12e-91 280.0 COG1519@1|root,COG1519@2|Bacteria,4NESA@976|Bacteroidetes,2FPNI@200643|Bacteroidia 976|Bacteroidetes M 3-Deoxy-D-manno-octulosonic-acid transferase waaA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N k59_745915_1 670487.Ocepr_0248 0.000201 48.9 COG1503@1|root,COG1503@2|Bacteria,1WJ3F@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J translation release factor activity - - - - - - - - - - - - Host_attach k59_944150_1 1168034.FH5T_09785 1.88e-28 110.0 COG1999@1|root,COG1999@2|Bacteria,4NU1J@976|Bacteroidetes,2FXFP@200643|Bacteroidia 976|Bacteroidetes S signal sequence binding - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1009123_1 1123020.AUIE01000028_gene2544 3.66e-49 163.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S4SZ@1236|Gammaproteobacteria,1YFYU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Lipocalin-like domain blc - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_419737_1 644076.SCH4B_2314 5.11e-18 85.5 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,2U77K@28211|Alphaproteobacteria,4NAWM@97050|Ruegeria 28211|Alphaproteobacteria G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_419737_2 882082.SaccyDRAFT_3658 0.000221 43.5 COG0129@1|root,COG0129@2|Bacteria,2GJHC@201174|Actinobacteria,4DY5G@85010|Pseudonocardiales 201174|Actinobacteria EG Belongs to the IlvD Edd family edd - 4.2.1.12 ko:K01690 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00008 R02036 RC00543 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_584629_1 1123274.KB899410_gene3507 9.02e-76 247.0 COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,2J6QT@203691|Spirochaetes 203691|Spirochaetes EGT Amino acid permease - - - - - - - - - - - - AA_permease,PTS_EIIA_2 k59_584629_2 572544.Ilyop_1688 9.63e-67 233.0 COG1452@1|root,COG1452@2|Bacteria,37983@32066|Fusobacteria 32066|Fusobacteria M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - k59_23446_1 911239.CF149_21073 3.06e-86 265.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Formyl_trans_C,Formyl_trans_N k59_23446_2 713587.THITH_15585 2.4e-29 109.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_877485_2 926556.Echvi_3772 8.73e-52 183.0 COG3250@1|root,COG3250@2|Bacteria,4NF4T@976|Bacteroidetes 976|Bacteroidetes G Beta-galactosidase - - - - - - - - - - - - Bgal_small_N,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_649883_1 1000565.METUNv1_01955 6.83e-74 231.0 28J3D@1|root,2Z8ZM@2|Bacteria,1R4AS@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3644) - - - - - - - - - - - - DUF3644 k59_649883_2 1121447.JONL01000009_gene2529 1.18e-72 226.0 COG1715@1|root,COG1715@2|Bacteria,1RABH@1224|Proteobacteria,42X1S@68525|delta/epsilon subdivisions,2WXD2@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Restriction endonuclease - - - - - - - - - - - - - k59_809015_1 1121859.KB890739_gene2407 4.5e-11 67.0 COG0797@1|root,COG1388@1|root,COG0797@2|Bacteria,COG1388@2|Bacteria,4NG96@976|Bacteroidetes,47NR5@768503|Cytophagia 976|Bacteroidetes M PFAM LysM domain lysM - - - - - - - - - - - ANF_receptor,LysM,Peripla_BP_6 k59_809015_2 1168034.FH5T_17705 6.79e-145 421.0 COG0519@1|root,COG0519@2|Bacteria,4NESX@976|Bacteroidetes,2FM3V@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_780266_1 420246.GTNG_1433 1.51e-17 77.0 COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,4HAPC@91061|Bacilli,1WG5E@129337|Geobacillus 91061|Bacilli P CorA-like Mg2+ transporter protein corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_780266_2 1379281.AVAG01000032_gene119 2.2e-43 154.0 COG0438@1|root,COG0438@2|Bacteria,1R8YI@1224|Proteobacteria,42N8I@68525|delta/epsilon subdivisions,2WIYJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_552747_1 318161.Sden_3360 1.19e-162 464.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q9Q5@267890|Shewanellaceae 1236|Gammaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_356316_1 1319815.HMPREF0202_00148 3.62e-16 84.3 COG1807@1|root,COG1807@2|Bacteria,3798I@32066|Fusobacteria 32066|Fusobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_453826_1 870187.Thini_4292 2.9e-170 484.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,45ZNA@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans - - - - - - - - - - - - NTP_transferase k59_419771_1 864051.BurJ1DRAFT_1464 6.51e-76 236.0 28JEH@1|root,2Z98N@2|Bacteria,1RIK2@1224|Proteobacteria,2VWXE@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_809038_1 1279038.KB907347_gene3228 2.72e-34 135.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2JPKY@204441|Rhodospirillales 204441|Rhodospirillales CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_617750_1 580340.Tlie_1477 1.76e-111 333.0 COG3958@1|root,COG3958@2|Bacteria,3TAN6@508458|Synergistetes 508458|Synergistetes G PFAM Transketolase, C-terminal domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_193167_1 546275.FUSPEROL_00625 4.3e-86 262.0 COG0115@1|root,COG0115@2|Bacteria,378G4@32066|Fusobacteria 32066|Fusobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_780295_2 1242969.ATCC51562_69 9.03e-32 111.0 COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2YQ19@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_780295_3 563040.Saut_1918 1.43e-20 88.6 COG1385@1|root,COG1385@2|Bacteria,1QDSD@1224|Proteobacteria,42S1W@68525|delta/epsilon subdivisions,2YP9M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_975913_1 765914.ThisiDRAFT_2344 2.15e-23 94.4 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1WY5Q@135613|Chromatiales 135613|Chromatiales S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_809054_1 518766.Rmar_2256 9.75e-12 65.1 COG1214@1|root,COG1214@2|Bacteria,4NDUR@976|Bacteroidetes,1FJGT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O Glycoprotease family yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_809054_2 96561.Dole_1856 3.59e-34 132.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_714808_1 765911.Thivi_3088 1.87e-42 146.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1WW5V@135613|Chromatiales 135613|Chromatiales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_714808_2 543728.Vapar_5879 5.84e-25 99.8 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2W2C7@28216|Betaproteobacteria,4AJAA@80864|Comamonadaceae 28216|Betaproteobacteria H PFAM glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_126589_2 1449126.JQKL01000024_gene2329 6.29e-06 48.1 2EGZP@1|root,33ART@2|Bacteria,1VKPB@1239|Firmicutes 1239|Firmicutes S YopX protein - - - - - - - - - - - - YopX k59_844954_1 349521.HCH_00571 9.32e-27 106.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1XK6E@135619|Oceanospirillales 135619|Oceanospirillales L Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_844954_2 1279019.ARQK01000053_gene2123 8.59e-20 83.6 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1WY42@135613|Chromatiales 135613|Chromatiales H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_257084_1 1452718.JBOY01000024_gene350 5.39e-54 189.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_910668_1 765910.MARPU_16465 4.75e-52 183.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_910668_2 323097.Nham_1137 3.33e-17 80.5 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3JS73@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C NADH NADPH, small subunit gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_328264_1 749222.Nitsa_0438 3.62e-91 278.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2YMQZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_426140_1 395493.BegalDRAFT_3164 2.67e-97 294.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,45ZNN@72273|Thiotrichales 72273|Thiotrichales C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_720449_1 102107.XP_008223735.1 7.42e-253 710.0 COG1007@1|root,KOG4668@2759|Eukaryota,37P90@33090|Viridiplantae,3GBJ3@35493|Streptophyta,4JRH7@91835|fabids 35493|Streptophyta C A subunit of NADH dehydrogenase ndhF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.6.5.3 ko:K05577 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_557080_1 1249480.B649_05015 1.29e-65 210.0 2AGMT@1|root,316V3@2|Bacteria,1PY20@1224|Proteobacteria,42NND@68525|delta/epsilon subdivisions,2YMQB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - pgbB - - - - - - - - - - - PGBA_C,PQQ_2 k59_197377_1 880072.Desac_2532 1.93e-106 324.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MQ8Y@213462|Syntrophobacterales 28221|Deltaproteobacteria H Thiamine pyrophosphate enzyme, central ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_66509_1 1265505.ATUG01000001_gene3218 1.51e-96 290.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,2MJTU@213118|Desulfobacterales 28221|Deltaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family yjiL - - - - - - - - - - - BcrAD_BadFG k59_66509_2 177437.HRM2_43030 2.01e-05 45.8 COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria,2MJN6@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - - - - - - - - - - HGD-D k59_687762_1 1168034.FH5T_07270 8.96e-129 377.0 COG1262@1|root,COG1262@2|Bacteria,4NGY2@976|Bacteroidetes,2FPTN@200643|Bacteroidia 976|Bacteroidetes M gliding motility-associated lipoprotein GldK gldK - - - - - - - - - - - FGE-sulfatase k59_230165_1 1123519.PSJM300_12305 7.02e-20 90.1 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1Z0NW@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S exporters of the RND superfamily IV02_10640 - - ko:K07003 - - - - ko00000 - - - MMPL k59_230165_2 666685.R2APBS1_3583 4.89e-15 69.7 COG5481@1|root,COG5481@2|Bacteria,1QB94@1224|Proteobacteria,1SHNI@1236|Gammaproteobacteria,1X8EV@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF465) - - - - - - - - - - - - DUF465 k59_1014587_2 269799.Gmet_2571 2.71e-36 132.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,42M13@68525|delta/epsilon subdivisions,2WPM0@28221|Deltaproteobacteria,43T5I@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_262550_1 177437.HRM2_49230 4.59e-29 114.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,42M3F@68525|delta/epsilon subdivisions,2WJ32@28221|Deltaproteobacteria,2MIH7@213118|Desulfobacterales 28221|Deltaproteobacteria EP Belongs to the ABC transporter superfamily oppD - - ko:K02031,ko:K12371,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00324,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_262550_2 329726.AM1_2079 1.16e-19 87.8 COG1173@1|root,COG1173@2|Bacteria,1G0CD@1117|Cyanobacteria 1117|Cyanobacteria P 'ABC-type dipeptide oligopeptide nickel transport appC - - ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1,OppC_N k59_622358_1 1168034.FH5T_01375 1.79e-95 280.0 COG1522@1|root,COG1522@2|Bacteria,4NMEN@976|Bacteroidetes,2FMP2@200643|Bacteroidia 976|Bacteroidetes K Transcriptional regulator, AsnC Family asnC - - ko:K03718 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_230177_1 1410608.JNKX01000038_gene1362 1.44e-39 142.0 COG3025@1|root,COG3025@2|Bacteria,4NM6K@976|Bacteroidetes,2FNF2@200643|Bacteroidia,4AMMM@815|Bacteroidaceae 976|Bacteroidetes S VTC domain - - - - - - - - - - - - VTC k59_1014595_1 1168034.FH5T_01470 3.59e-140 407.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FWYQ@200643|Bacteroidia 976|Bacteroidetes T Sigma-54 interaction domain - - - - - - - - - - - - Response_reg,Sigma54_activat k59_393609_1 572544.Ilyop_1679 2.83e-90 275.0 COG1420@1|root,COG1420@2|Bacteria,3792S@32066|Fusobacteria 32066|Fusobacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA k59_655181_1 1408439.JHXW01000012_gene894 1.39e-122 374.0 COG1080@1|root,COG1080@2|Bacteria,378UT@32066|Fusobacteria 32066|Fusobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsP - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_655181_2 1168034.FH5T_12195 0.0 1208.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,4NEHE@976|Bacteroidetes,2FM8K@200643|Bacteroidia 976|Bacteroidetes G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_655181_3 1121289.JHVL01000039_gene3136 1.68e-213 603.0 COG2610@1|root,COG2610@2|Bacteria,1TQJ6@1239|Firmicutes,24839@186801|Clostridia,36DCD@31979|Clostridiaceae 186801|Clostridia EG Citrate transporter - - - - - - - - - - - - GntP_permease,Na_H_antiporter k59_99337_1 247634.GPB2148_1175 2.76e-126 371.0 COG3633@1|root,COG3633@2|Bacteria,1MXE1@1224|Proteobacteria,1RP9B@1236|Gammaproteobacteria,1J4YA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) sstT GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005295,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015175,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032329,GO:0034220,GO:0035725,GO:0044425,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039 - ko:K07862 - - - - ko00000,ko02000 2.A.23.4 - iAF1260.b3089,iBWG_1329.BWG_2799,iECDH10B_1368.ECDH10B_3265,iECDH1ME8569_1439.ECDH1ME8569_2984,iECH74115_1262.ECH74115_4404,iECIAI1_1343.ECIAI1_3235,iECO103_1326.ECO103_3834,iECO111_1330.ECO111_3911,iECO26_1355.ECO26_4192,iECP_1309.ECP_3180,iECSE_1348.ECSE_3370,iECSP_1301.ECSP_4063,iECUMN_1333.ECUMN_3573,iECW_1372.ECW_m3356,iECs_1301.ECs3971,iEKO11_1354.EKO11_0630,iETEC_1333.ETEC_3359,iEcDH1_1363.EcDH1_0612,iEcE24377_1341.EcE24377A_3557,iG2583_1286.G2583_3813,iJO1366.b3089,iJR904.b3089,iSFV_1184.SFV_3130,iSSON_1240.SSON_3242,iUMNK88_1353.UMNK88_3845,iWFL_1372.ECW_m3356,iY75_1357.Y75_RS16050,iYL1228.KPN_03517,iZ_1308.Z4442 SDF k59_328299_1 469371.Tbis_2384 3.11e-19 92.0 COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,2GKN1@201174|Actinobacteria,4DYY0@85010|Pseudonocardiales 201174|Actinobacteria CK Acyl-CoA synthetase (NDP forming) - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_262565_1 1303518.CCALI_01606 1.43e-25 110.0 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - - ko:K14274,ko:K20276 ko00040,ko02024,map00040,map02024 - R02427 RC00713 ko00000,ko00001,ko01000 - - - DUF5122,He_PIG,SBBP,SGL k59_66511_2 526218.Sterm_1003 3.78e-111 325.0 COG0310@1|root,COG0310@2|Bacteria,379XW@32066|Fusobacteria 32066|Fusobacteria P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import cbiM - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_66511_3 526218.Sterm_1004 2.09e-34 120.0 COG1930@1|root,COG1930@2|Bacteria,37B39@32066|Fusobacteria 32066|Fusobacteria P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import cbiN - - ko:K02009 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18 - - CbiN k59_66511_4 1321779.HMPREF1984_00904 2.87e-65 209.0 COG0619@1|root,COG0619@2|Bacteria,37AW2@32066|Fusobacteria 32066|Fusobacteria P Cobalt ABC transporter, permease cbiQ - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ k59_66511_5 1227268.HMPREF1552_00973 6.8e-100 300.0 COG1122@1|root,COG1122@2|Bacteria,37A2F@32066|Fusobacteria 32066|Fusobacteria P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates - - - ko:K02006,ko:K16786 ko02010,map02010 M00245,M00246,M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k59_66511_6 526218.Sterm_1007 6.09e-203 575.0 COG1797@1|root,COG1797@2|Bacteria,378GY@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_851300_1 572544.Ilyop_0226 2.02e-95 290.0 COG0006@1|root,COG0006@2|Bacteria,379I8@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_851300_2 523794.Lebu_0523 6.71e-142 413.0 COG0482@1|root,COG0482@2|Bacteria,379BG@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 - - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_360993_1 324925.Ppha_1997 1.48e-29 121.0 COG4772@1|root,COG4772@2|Bacteria,1FD5S@1090|Chlorobi 1090|Chlorobi M TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3 k59_393616_1 189753.AXAS01000001_gene3605 1.05e-19 88.6 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JYI1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Resolvase, N terminal domain - - - - - - - - - - - - HTH_7,Recombinase,Resolvase k59_818491_1 469617.FUAG_01181 1.75e-88 275.0 COG0635@1|root,COG0635@2|Bacteria,3788G@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score 9.97 hemZ - - - - - - - - - - - Radical_SAM k59_360999_1 1165841.SULAR_02863 5.44e-30 110.0 2DMVP@1|root,32TYU@2|Bacteria,1MZ9J@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_360999_2 929558.SMGD1_0017 7.61e-38 137.0 COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,42MN0@68525|delta/epsilon subdivisions,2YRFV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E M18 family aminopeptidase - - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k59_164883_1 762982.HMPREF9442_02509 5.61e-19 90.1 COG2335@1|root,COG2335@2|Bacteria,4NGU3@976|Bacteroidetes,2FRBQ@200643|Bacteroidia 976|Bacteroidetes M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - ko:K19519 - - - - ko00000,ko04516 - - - Fasciclin k59_1019_1 1410626.JHXB01000011_gene1919 7.71e-82 261.0 COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia,27UFU@186928|unclassified Lachnospiraceae 186801|Clostridia G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_557130_1 1163617.SCD_n00416 9.1e-51 179.0 COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2VJXF@28216|Betaproteobacteria 28216|Betaproteobacteria U hemolysin activation secretion protein - - - - - - - - - - - - POTRA_2,ShlB k59_1014609_1 272563.CD630_08370 2.06e-21 89.4 COG0778@1|root,COG0778@2|Bacteria,1V3FH@1239|Firmicutes,24HM3@186801|Clostridia,25RZP@186804|Peptostreptococcaceae 186801|Clostridia C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_1014609_2 857293.CAAU_1353 7.72e-19 89.7 COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia,36GX1@31979|Clostridiaceae 186801|Clostridia S Metal-dependent hydrolase - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_720496_2 746697.Aeqsu_0883 1.52e-77 240.0 COG0810@1|root,COG0810@2|Bacteria,4NMG7@976|Bacteroidetes,1HX5H@117743|Flavobacteriia 976|Bacteroidetes M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_589752_1 243233.MCA2495 1.4e-15 75.9 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1XDTI@135618|Methylococcales 135618|Methylococcales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_589752_2 1439940.BAY1663_00430 2.82e-47 158.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_883919_1 1168034.FH5T_21015 1.57e-173 490.0 COG2070@1|root,COG2070@2|Bacteria,4NF8Z@976|Bacteroidetes,2FMYA@200643|Bacteroidia 976|Bacteroidetes S 2-nitropropane dioxygenase fabK - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_230193_1 335284.Pcryo_0924 8.61e-05 52.0 COG2378@1|root,COG2378@2|Bacteria,1R65H@1224|Proteobacteria,1S63H@1236|Gammaproteobacteria,3NM7J@468|Moraxellaceae 1236|Gammaproteobacteria K WYL domain - - - - - - - - - - - - HTH_11,HTH_DeoR,WYL k59_230193_3 666685.R2APBS1_2092 6.64e-64 213.0 COG3621@1|root,COG3621@2|Bacteria,1R852@1224|Proteobacteria,1S106@1236|Gammaproteobacteria,1X65G@135614|Xanthomonadales 135614|Xanthomonadales S PFAM Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_230193_4 1229204.AMYY01000003_gene938 2.9e-68 224.0 28KCT@1|root,2ZHKZ@2|Bacteria,1QYAC@1224|Proteobacteria,2U43Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_459028_1 484770.UFO1_3156 1.13e-135 392.0 COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,4H51I@909932|Negativicutes 909932|Negativicutes K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_590083_2 1118059.CAHC01000017_gene467 1.54e-07 60.1 COG4591@1|root,COG4591@2|Bacteria,1VBN5@1239|Firmicutes,25EBV@186801|Clostridia 186801|Clostridia M permease - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_982179_1 563040.Saut_1407 5.96e-194 550.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2YN93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH anthranilate synthase component trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP1282 Anth_synt_I_N,Chorismate_bind k59_982179_2 1089553.Tph_c16700 1.94e-05 46.2 COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,42ES9@68295|Thermoanaerobacterales 186801|Clostridia E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_230555_1 649639.Bcell_0741 2.4e-16 84.7 COG0745@1|root,COG4251@1|root,COG5002@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1UMIM@1239|Firmicutes,4ITVY@91061|Bacilli,1ZSDG@1386|Bacillus 91061|Bacilli T 7TMR-DISM extracellular 2 - - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Response_reg k59_459436_1 999413.HMPREF1094_03944 4.34e-56 190.0 COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,3VNVV@526524|Erysipelotrichia 526524|Erysipelotrichia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_459436_2 1249627.D779_2949 9.91e-07 50.4 COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria,1WYND@135613|Chromatiales 135613|Chromatiales C ATP synthase subunit D - - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_949673_1 1120983.KB894570_gene1242 7.88e-62 212.0 COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2TQXU@28211|Alphaproteobacteria,1JQ14@119043|Rhodobiaceae 28211|Alphaproteobacteria C Conserved carboxylase domain pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_949673_2 378806.STAUR_1777 2.26e-48 167.0 COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,42NRH@68525|delta/epsilon subdivisions,2WNIB@28221|Deltaproteobacteria,2YV7G@29|Myxococcales 28221|Deltaproteobacteria E Asparaginase - - 3.4.19.5 ko:K13051 - - - - ko00000,ko01000,ko01002 - - - Asparaginase_2 k59_197783_1 272560.BPSL2207 2.15e-90 289.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,1KDQ8@119060|Burkholderiaceae 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_786131_1 1163617.SCD_n02414 1.83e-48 160.0 COG0500@1|root,COG0500@2|Bacteria,1RDHE@1224|Proteobacteria,2VQIP@28216|Betaproteobacteria 28216|Betaproteobacteria Q Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_786131_2 1045855.DSC_07925 4.33e-09 55.8 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1SAR9@1236|Gammaproteobacteria,1X6P4@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the small heat shock protein (HSP20) family hspA - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_982181_1 1168034.FH5T_08810 2.57e-121 354.0 COG0489@1|root,COG0489@2|Bacteria,4NF5I@976|Bacteroidetes,2FKYK@200643|Bacteroidia 976|Bacteroidetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_557545_1 1344012.ATMI01000002_gene1489 3.78e-55 188.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,4BUB9@82986|Tatumella 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_655596_1 159087.Daro_0175 2.28e-35 135.0 COG1819@1|root,COG1819@2|Bacteria,1MVJM@1224|Proteobacteria,2VME8@28216|Betaproteobacteria,2KXTJ@206389|Rhodocyclales 206389|Rhodocyclales CG glycosyl - - - - - - - - - - - - - k59_590090_1 85643.Tmz1t_3383 1.34e-25 108.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales 206389|Rhodocyclales O HflC and HflK could encode or regulate a protease - - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_917075_1 1408473.JHXO01000001_gene2394 6.59e-09 56.6 28HHN@1|root,2Z7TA@2|Bacteria,4NEXR@976|Bacteroidetes,2FQ6G@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_917075_2 1168034.FH5T_05440 2.54e-65 200.0 COG1314@1|root,COG1314@2|Bacteria,4NUYQ@976|Bacteroidetes,2FSK4@200643|Bacteroidia 976|Bacteroidetes U Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_165296_1 1123240.ATVO01000006_gene1505 0.000109 45.4 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria,2K13Q@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_165296_2 909663.KI867150_gene678 2e-29 117.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MR7G@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1014948_1 1322246.BN4_12276 1.42e-90 285.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2M8PA@213115|Desulfovibrionales 28221|Deltaproteobacteria P transporter antisigma-factor antagonist STAS - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_459445_2 387093.SUN_1969 8.2e-77 231.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,42THF@68525|delta/epsilon subdivisions,2YPXJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_459445_3 326298.Suden_0679 1.1e-07 52.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2YMPP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H riboflavin biosynthesis protein ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_361400_1 1166018.FAES_1517 3.39e-103 338.0 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,47Y9P@768503|Cytophagia 976|Bacteroidetes P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_851696_1 1249480.B649_01275 7.32e-36 137.0 COG4773@1|root,COG4773@2|Bacteria,1QZMX@1224|Proteobacteria,42SA0@68525|delta/epsilon subdivisions,2YPCD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - - k59_426495_1 869213.JCM21142_41684 3.16e-61 211.0 COG0348@1|root,COG0348@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - FMN_bind,Fer4,Fer4_5 k59_230576_1 1249480.B649_08330 2.77e-44 150.0 COG0340@1|root,COG0340@2|Bacteria,1Q1NZ@1224|Proteobacteria,42RQM@68525|delta/epsilon subdivisions,2YP5C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H biotin acetyl-CoA-carboxylase ligase birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_LplA_LipB k59_230576_2 563040.Saut_0767 1.3e-17 81.6 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2YMQZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_655611_1 1168034.FH5T_01895 1.34e-79 263.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,4NETY@976|Bacteroidetes,2FM2Z@200643|Bacteroidia 976|Bacteroidetes F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_917092_1 1038922.PflQ2_4000 1.33e-76 244.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1 k59_1276_1 1121405.dsmv_0470 7.74e-22 94.0 COG1680@1|root,COG1680@2|Bacteria,1QUYZ@1224|Proteobacteria,42PUC@68525|delta/epsilon subdivisions,2WK0V@28221|Deltaproteobacteria,2MIWD@213118|Desulfobacterales 28221|Deltaproteobacteria V PFAM Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_692260_1 1121921.KB898706_gene2937 2.97e-42 147.0 COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,2PNIR@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Las17-binding protein actin regulator CT2216 - - - - - - - - - - - Ysc84 k59_692260_2 366602.Caul_1065 1.12e-50 175.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2KFF3@204458|Caulobacterales 204458|Caulobacterales E Peptidase dimerisation domain - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_71174_1 1385517.N800_00100 8.52e-85 265.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1X3CQ@135614|Xanthomonadales 135614|Xanthomonadales E Transporter yhiP - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_464104_1 1123326.JFBL01000001_gene1406 1.87e-51 176.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2YMTP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_266778_1 657309.BXY_03800 2.62e-100 315.0 COG3525@1|root,COG3525@2|Bacteria,4NH5U@976|Bacteroidetes,2FP3E@200643|Bacteroidia,4AMTH@815|Bacteroidaceae 976|Bacteroidetes G Glycosyl hydrolase, family 20, catalytic domain - - - - - - - - - - - - Glyco_hydro_20b k59_71180_1 944547.ABLL_2255 4.26e-11 66.2 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2YR92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C IG-like fold at C-terminal of FixG, putative oxidoreductase - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_823167_2 85643.Tmz1t_2809 3.66e-23 91.3 COG2104@1|root,COG2104@2|Bacteria,1N9VX@1224|Proteobacteria,2VVYE@28216|Betaproteobacteria,2KZAT@206389|Rhodocyclales 206389|Rhodocyclales H Mut7-C ubiquitin - - - - - - - - - - - - ThiS k59_823167_3 1265502.KB905933_gene2063 2.2e-35 131.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2WH5F@28216|Betaproteobacteria,4ABYG@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_333174_1 1128421.JAGA01000002_gene1302 4.64e-21 94.7 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,2NR31@2323|unclassified Bacteria 2|Bacteria K helix_turn_helix, mercury resistance ycgE - - ko:K21089,ko:K21972,ko:K22491 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_299525_1 1316936.K678_04221 3.02e-71 226.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,2JPIB@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_692858_1 1122194.AUHU01000016_gene1880 9.56e-30 125.0 COG3507@1|root,COG5297@1|root,COG3507@2|Bacteria,COG5297@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase family 6 - - 3.2.1.4,3.2.1.78,3.2.1.91 ko:K01179,ko:K01218,ko:K19668 ko00051,ko00500,ko01100,ko02020,ko02024,map00051,map00500,map01100,map02020,map02024 - R01332,R02886,R06200,R11307,R11308 RC00467,RC00799 ko00000,ko00001,ko01000 - GH26,GH5,GH6,GH9 - CBM60,CBM_10,CBM_2,CBM_6,Cellulase,Glyco_hydro_11,Glyco_hydro_12,Glyco_hydro_26,Glyco_hydro_43,Glyco_hydro_45,Glyco_hydro_6,Malectin,PKD,Pec_lyase,RicinB_lectin_2 k59_823715_1 1304284.L21TH_2427 4.43e-14 76.6 COG1875@1|root,COG1875@2|Bacteria,1UHTD@1239|Firmicutes,25ED1@186801|Clostridia,36EGB@31979|Clostridiaceae 186801|Clostridia T PFAM PhoH family protein - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_366283_1 472759.Nhal_3943 6.3e-70 230.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales 135613|Chromatiales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_627641_1 1122180.Lokhon_01586 1.94e-26 110.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2P9M4@245186|Loktanella 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM k59_562581_1 1123354.AUDR01000012_gene1670 4.98e-67 215.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,1KRHX@119069|Hydrogenophilales 119069|Hydrogenophilales P Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_562581_2 1304883.KI912532_gene1045 1.92e-15 75.1 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI5E@28216|Betaproteobacteria,2KUQW@206389|Rhodocyclales 206389|Rhodocyclales P nitrite transporter - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_497086_1 326298.Suden_2028 3.53e-189 531.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,42P59@68525|delta/epsilon subdivisions,2YMPJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0324 family - - - - - - - - - - - - Cons_hypoth698 k59_366287_2 1379698.RBG1_1C00001G0296 4.9e-23 96.7 COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 k59_757769_1 580332.Slit_1682 5.38e-35 122.0 COG2168@1|root,COG2168@2|Bacteria,1PTT8@1224|Proteobacteria,2VWF4@28216|Betaproteobacteria,44WHZ@713636|Nitrosomonadales 28216|Betaproteobacteria P DsrH like protein - - - ko:K07237 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DsrH k59_757769_2 864051.BurJ1DRAFT_3333 2.01e-21 87.4 COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,2VSQ5@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfur relay protein TusC DsrF - - - ko:K07236 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DrsE k59_71971_2 387092.NIS_0152 8.94e-11 62.8 2C7AP@1|root,2ZK7Q@2|Bacteria,1Q6IS@1224|Proteobacteria,4338D@68525|delta/epsilon subdivisions,2YSHU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_464672_1 1200792.AKYF01000017_gene5565 1.33e-63 224.0 COG0236@1|root,COG1028@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksL - - ko:K13613 - - - - ko00000,ko01004,ko01008 - - - ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_594581_1 1123355.JHYO01000002_gene1270 1.22e-11 60.5 COG0298@1|root,COG0298@2|Bacteria,1PRY6@1224|Proteobacteria,2V45S@28211|Alphaproteobacteria,36YX4@31993|Methylocystaceae 28211|Alphaproteobacteria O HupF/HypC family - - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_823729_1 2340.JV46_14280 2.41e-115 345.0 COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - - - - - - - - - - ATP-synt_ab k59_38382_1 357804.Ping_1216 3.61e-174 497.0 COG0377@1|root,COG3383@1|root,COG0377@2|Bacteria,COG3383@2|Bacteria,1MXTC@1224|Proteobacteria,1RZDX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C NADH ubiquinone oxidoreductase - - 1.12.1.2 ko:K18006,ko:K18007 - - - - ko00000,ko01000 - - - Fer2_4,Fer4_15,NADH-G_4Fe-4S_3 k59_38382_2 686340.Metal_1159 1.13e-245 688.0 COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1XDSA@135618|Methylococcales 135618|Methylococcales C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.1.2 ko:K00436 - - R00700 - ko00000,ko01000 - - - NiFeSe_Hases k59_38382_3 640081.Dsui_3026 1.13e-26 105.0 COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,2VTPX@28216|Betaproteobacteria,2KWJ7@206389|Rhodocyclales 206389|Rhodocyclales C maturation - - - - - - - - - - - - - k59_38382_4 1049564.TevJSym_ai00340 0.0 1395.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1J534@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_38382_5 754477.Q7C_2272 1.33e-56 186.0 COG0204@1|root,COG0204@2|Bacteria,1PDUQ@1224|Proteobacteria,1S51R@1236|Gammaproteobacteria,462J0@72273|Thiotrichales 72273|Thiotrichales I TIGRFAM 1-acyl-sn-glycerol-3-phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_38382_6 1049564.TevJSym_ai00140 1.75e-83 250.0 COG0242@1|root,COG0242@2|Bacteria,1QM3A@1224|Proteobacteria,1RZHN@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_38382_7 1049564.TevJSym_ai00150 1.36e-72 223.0 COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,1S2A4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_38382_8 765912.Thimo_2185 8.28e-99 295.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1WX0I@135613|Chromatiales 135613|Chromatiales S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_38382_9 686340.Metal_3260 1.95e-133 389.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1XEJR@135618|Methylococcales 135618|Methylococcales J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_38382_10 1249627.D779_1505 5.97e-106 314.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1WX6S@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_38382_11 634176.NT05HA_1533 5.39e-57 179.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1Y8QJ@135625|Pasteurellales 135625|Pasteurellales K Belongs to the P(II) protein family glnB - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_38382_12 2340.JV46_15620 9.96e-259 724.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1J4VX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_38382_13 1286106.MPL1_04452 1.67e-164 465.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,45ZX8@72273|Thiotrichales 72273|Thiotrichales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_38382_14 2340.JV46_15640 8.83e-190 537.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1J53T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_38382_15 983917.RGE_42360 5.21e-06 47.4 2A94H@1|root,30Y8N@2|Bacteria,1PK47@1224|Proteobacteria,2W8EQ@28216|Betaproteobacteria,1KMTS@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - ko:K06950 - - - - ko00000 - - - - k59_38382_16 395493.BegalDRAFT_1870 8.1e-124 381.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,45ZTT@72273|Thiotrichales 72273|Thiotrichales T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA k59_38382_17 472759.Nhal_0598 3.23e-186 533.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WVVT@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_38382_18 1217715.F994_00344 6.24e-23 96.7 COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Belongs to the N-Me-Phe pilin family pilA - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_38382_19 1049564.TevJSym_ai00290 2.27e-287 799.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1J4Y2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_38382_20 1049564.TevJSym_ai00300 4.85e-194 550.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1J4VW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretory pathway, component PulF pilC GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009297,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0032940,GO:0033036,GO:0042886,GO:0043711,GO:0044085,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0098776 - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_38382_21 95619.PM1_0205830 1.16e-103 309.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria 1236|Gammaproteobacteria NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02464,ko:K02654 ko03070,map03070 M00331 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15,3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_38382_22 697282.Mettu_2519 1.15e-61 197.0 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1XF4I@135618|Methylococcales 135618|Methylococcales F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_38382_23 631362.Thi970DRAFT_02206 7.56e-68 217.0 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1WWH6@135613|Chromatiales 135613|Chromatiales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_38382_24 572477.Alvin_0145 2.42e-92 284.0 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1WW2I@135613|Chromatiales 135613|Chromatiales HL Thiamine monophosphate synthase - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,NUDIX_4,TMP-TENI k59_38382_25 2340.JV46_02110 5e-229 641.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1J4PR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_38382_27 530564.Psta_4139 7.78e-45 153.0 COG2096@1|root,COG2096@2|Bacteria,2IZZ0@203682|Planctomycetes 203682|Planctomycetes S PFAM Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_38382_28 2340.JV46_25690 1.78e-41 142.0 COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,1S5YP@1236|Gammaproteobacteria,1J66I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 fkpB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03774 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_38382_29 1283300.ATXB01000001_gene494 6.43e-153 437.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1XEJA@135618|Methylococcales 135618|Methylococcales IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_38382_30 1123296.JQKE01000012_gene177 1.7e-07 54.7 COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,2VW3E@28216|Betaproteobacteria,2KRYU@206351|Neisseriales 206351|Neisseriales NU Type IV minor pilin ComP, DNA uptake sequence receptor - - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_38382_31 697282.Mettu_0317 0.0 1066.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1XDKW@135618|Methylococcales 135618|Methylococcales NU Neisseria PilC beta-propeller domain - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_38382_32 187272.Mlg_0861 0.000782 47.4 COG4726@1|root,COG4726@2|Bacteria,1NN2C@1224|Proteobacteria,1SRGZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU PilX N-terminal - - - - - - - - - - - - PilX_N k59_38382_33 644801.Psest_3372 6.22e-23 105.0 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1SX1M@1236|Gammaproteobacteria,1Z3JE@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_38382_34 443152.MDG893_12924 2.73e-28 110.0 COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria,46937@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG4967 Tfp pilus assembly protein PilV pilV - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_38382_35 1395571.TMS3_0106830 5.65e-10 62.0 COG4970@1|root,COG4970@2|Bacteria 2|Bacteria NU protein transport across the cell outer membrane fimT - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_922212_2 1384056.N787_08565 0.000157 45.4 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1X4VI@135614|Xanthomonadales 135614|Xanthomonadales D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_954122_1 883.DvMF_1122 7.06e-44 163.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,42NZ8@68525|delta/epsilon subdivisions,2WK0Y@28221|Deltaproteobacteria,2M9MM@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K01286,ko:K07258,ko:K07262 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_954122_2 1408439.JHXW01000010_gene95 1.87e-25 97.1 COG0822@1|root,COG0822@2|Bacteria,37A6D@32066|Fusobacteria 32066|Fusobacteria C NifU-like N terminal domain nifU - - ko:K04488 - - - - ko00000 - - - NifU_N k59_660784_1 667014.Thein_1747 1.71e-33 118.0 COG2827@1|root,COG2827@2|Bacteria 2|Bacteria L Endonuclease containing a URI domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_300118_1 469615.FGAG_00591 1.82e-247 690.0 COG0488@1|root,COG0488@2|Bacteria,378CA@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 9.97 - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_300118_2 1480694.DC28_13275 3.38e-26 99.4 arCOG15062@1|root,32Y8D@2|Bacteria,2J908@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - PQ-loop k59_823734_1 387093.SUN_0509 2.44e-85 260.0 COG3301@1|root,COG3301@2|Bacteria,1QSRQ@1224|Proteobacteria,42PAY@68525|delta/epsilon subdivisions,2YN5Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_235315_2 1121324.CLIT_2c03640 5.45e-26 100.0 COG2406@1|root,COG2406@2|Bacteria,1VD9N@1239|Firmicutes,24Q5S@186801|Clostridia 186801|Clostridia S Ferritin-like domain - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_235315_3 1449126.JQKL01000008_gene293 1.88e-155 456.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,267RV@186813|unclassified Clostridiales 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_497110_2 563040.Saut_1024 1.6e-23 92.8 COG3668@1|root,COG3668@2|Bacteria,1PZJG@1224|Proteobacteria,42Y3N@68525|delta/epsilon subdivisions,2YQTP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_856450_1 1195246.AGRI_02755 1.53e-05 52.4 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,464GW@72275|Alteromonadaceae 1236|Gammaproteobacteria S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_71991_1 613026.HRAG_01430 2.45e-40 142.0 COG3271@1|root,COG3271@2|Bacteria,1N1ZY@1224|Proteobacteria,43BBJ@68525|delta/epsilon subdivisions 1224|Proteobacteria S Peptidase C39 family - - - ko:K06992 - - - - ko00000 - - - Peptidase_C39 k59_333980_1 749222.Nitsa_1752 8.17e-54 184.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2YN87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Abc transporter nikZ - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_430720_1 234267.Acid_1440 6.81e-17 82.8 COG0639@1|root,COG0639@2|Bacteria 2|Bacteria T phosphoprotein phosphatase activity - - 6.5.1.3 ko:K14680 - - - - ko00000,ko01000 - - - Metallophos_2,RNA_lig_T4_1 k59_692903_1 1158610.UC3_02305 3.35e-56 189.0 COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4HCSN@91061|Bacilli,4B3MJ@81852|Enterococcaceae 91061|Bacilli G Periplasmic binding protein domain - - - ko:K17213 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 k59_38395_1 292415.Tbd_2761 8.37e-16 79.3 COG3713@1|root,COG3713@2|Bacteria,1R5JE@1224|Proteobacteria,2VKVW@28216|Betaproteobacteria,1KSAF@119069|Hydrogenophilales 119069|Hydrogenophilales M MltA-interacting protein MipA - - - - - - - - - - - - MipA k59_888394_1 563040.Saut_1116 1.24e-104 313.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2YMJ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_922231_1 1123261.AXDW01000001_gene1353 6.19e-11 68.6 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1X53W@135614|Xanthomonadales 135614|Xanthomonadales S L,D-transpeptidase catalytic domain - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_42004_1 944547.ABLL_1415 7.1e-34 127.0 2B2M3@1|root,31V6H@2|Bacteria,1QT2M@1224|Proteobacteria,42ZNF@68525|delta/epsilon subdivisions,2YRQ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_174808_1 1122194.AUHU01000002_gene2749 4.9e-20 90.9 290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,1S3RZ@1236|Gammaproteobacteria,4675M@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_402695_1 522306.CAP2UW1_2245 1.2e-75 248.0 28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,2VMEK@28216|Betaproteobacteria 28216|Betaproteobacteria M Pfam Fatty acid cti - - - - - - - - - - - CTI k59_6845_1 367737.Abu_1911 1.9e-49 177.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2YMJ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell division protein FtsI penicillin-binding protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_893127_1 314230.DSM3645_21092 8.3e-114 340.0 COG3119@1|root,COG3119@2|Bacteria,2IXNZ@203682|Planctomycetes 203682|Planctomycetes P PFAM sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_402698_2 1123371.ATXH01000009_gene1095 1.04e-32 128.0 2DBKT@1|root,2Z9V9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_566904_1 941449.dsx2_0327 4.78e-11 63.2 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,42U8K@68525|delta/epsilon subdivisions,2WQZR@28221|Deltaproteobacteria,2MCI3@213115|Desulfovibrionales 28221|Deltaproteobacteria K RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_174816_1 1168034.FH5T_17715 5.96e-92 271.0 28H8R@1|root,2Z7KJ@2|Bacteria,4NGZN@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1023624_1 1172190.M947_02885 1.08e-240 674.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2YM7I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0354 DXP_synthase_N,Transket_pyr,Transketolase_C k59_338790_1 1385515.N791_00460 2.06e-96 297.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1X4K3@135614|Xanthomonadales 135614|Xanthomonadales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_534702_1 1168034.FH5T_12430 4.05e-101 296.0 COG1595@1|root,COG1595@2|Bacteria,4NIRG@976|Bacteroidetes,2FRYA@200643|Bacteroidia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_534702_2 1168034.FH5T_12435 4.62e-34 122.0 COG0357@1|root,COG0357@2|Bacteria,4NEJG@976|Bacteroidetes,2FMRQ@200643|Bacteroidia 976|Bacteroidetes J Specifically methylates the N7 position of a guanine in 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_501955_3 889378.Spiaf_2831 2.24e-18 84.3 COG0029@1|root,COG0029@2|Bacteria,2JBD7@203691|Spirochaetes 203691|Spirochaetes H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_566913_1 395494.Galf_2248 2.84e-09 54.3 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,44VZ3@713636|Nitrosomonadales 28216|Betaproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_566913_2 765911.Thivi_4575 2.93e-105 327.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales 135613|Chromatiales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_109348_1 1168034.FH5T_11530 8.17e-150 436.0 COG2239@1|root,COG2239@2|Bacteria,4NGGN@976|Bacteroidetes,2FN1M@200643|Bacteroidia 976|Bacteroidetes P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_142648_1 326298.Suden_2053 4.31e-55 187.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,42NZ4@68525|delta/epsilon subdivisions,2YNNY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I COG2067 Long-chain fatty acid transport protein - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_76493_1 1116472.MGMO_77c00230 3.92e-48 169.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1XE5G@135618|Methylococcales 135618|Methylococcales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_761898_1 96561.Dole_1156 2.45e-168 573.0 COG3209@1|root,COG3485@1|root,COG3209@2|Bacteria,COG3485@2|Bacteria,1MVV1@1224|Proteobacteria,43AER@68525|delta/epsilon subdivisions,2X5UG@28221|Deltaproteobacteria,2MN6Q@213118|Desulfobacterales 28221|Deltaproteobacteria GM PFAM NHL repeat containing protein - - - - - - - - - - - - CarboxypepD_reg,NHL,RHS_repeat k59_534707_1 870187.Thini_2393 1.03e-93 281.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,4604S@72273|Thiotrichales 72273|Thiotrichales J glycyl-tRNA synthetase, alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_534707_2 1523503.JPMY01000046_gene1178 1.79e-20 92.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f k59_1023631_2 867903.ThesuDRAFT_00646 1.94e-107 324.0 COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,3WCDJ@538999|Clostridiales incertae sedis 186801|Clostridia D TIGRFAM cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_142659_2 1249480.B649_03920 7.17e-88 267.0 COG0656@1|root,COG0656@2|Bacteria,1PGB3@1224|Proteobacteria,42PPT@68525|delta/epsilon subdivisions,2YN3U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_468549_1 749222.Nitsa_2107 1.6e-30 113.0 COG1314@1|root,COG1314@2|Bacteria,1NJ1D@1224|Proteobacteria,42TKW@68525|delta/epsilon subdivisions,2YPUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Preprotein translocase subunit SecG secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_1023632_1 1168034.FH5T_01680 4.24e-17 80.5 COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,2FREU@200643|Bacteroidia 976|Bacteroidetes H Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1023632_2 1168034.FH5T_01675 1.62e-137 400.0 COG0183@1|root,COG0183@2|Bacteria,4NE3Q@976|Bacteroidetes,2FQIE@200643|Bacteroidia 976|Bacteroidetes I Belongs to the thiolase family pcaF - - - - - - - - - - - Thiolase_C,Thiolase_N k59_303938_1 497964.CfE428DRAFT_5209 6.43e-57 195.0 COG0365@1|root,COG0365@2|Bacteria 2|Bacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1,6.2.1.16 ko:K01895,ko:K01907 ko00010,ko00280,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00280,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354,R01357 RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_697108_1 933262.AXAM01000010_gene1394 3e-05 50.8 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MHS7@213118|Desulfobacterales 28221|Deltaproteobacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_566943_1 398720.MED217_04562 9.22e-62 218.0 COG4206@1|root,COG4206@2|Bacteria,4NHTX@976|Bacteroidetes,1I7EP@117743|Flavobacteriia,2XJUR@283735|Leeuwenhoekiella 976|Bacteroidetes H TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_370765_1 997829.HMPREF1121_00256 4.18e-73 238.0 COG0536@1|root,COG0536@2|Bacteria,4NEK4@976|Bacteroidetes,2FM6Z@200643|Bacteroidia,22W3F@171551|Porphyromonadaceae 976|Bacteroidetes S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_370765_2 1148.1653395 4.24e-120 368.0 COG0064@1|root,COG0064@2|Bacteria,1G0H0@1117|Cyanobacteria,1H57V@1142|Synechocystis 1117|Cyanobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_665300_1 1121405.dsmv_3389 1.07e-56 181.0 COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,42RXS@68525|delta/epsilon subdivisions,2WNA0@28221|Deltaproteobacteria,2MJTK@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM transcription factor CarD - - - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF k59_665300_2 1121405.dsmv_3390 5.72e-08 55.1 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2WKX9@28221|Deltaproteobacteria,2MI4G@213118|Desulfobacterales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_142680_1 857087.Metme_0904 1.97e-56 189.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria 1236|Gammaproteobacteria U general secretion pathway protein lspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_434904_1 1227739.Hsw_3277 1.51e-17 87.4 COG2885@1|root,COG2885@2|Bacteria,4NE8J@976|Bacteroidetes,47PTE@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - OMP_b-brl,OmpA,TSP_3 k59_207344_2 1234364.AMSF01000033_gene430 1.19e-77 236.0 COG1765@1|root,COG1765@2|Bacteria,1PHC3@1224|Proteobacteria,1TA7C@1236|Gammaproteobacteria,1X8WZ@135614|Xanthomonadales 135614|Xanthomonadales O OsmC-like protein - - - - - - - - - - - - OsmC k59_926726_1 765911.Thivi_3113 2.96e-136 408.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,1S0DI@1236|Gammaproteobacteria,1X0D5@135613|Chromatiales 135613|Chromatiales C Methyl-viologen-reducing hydrogenase, delta subunit - - - ko:K16886 - - - - ko00000 - - - Fer4,FlpD k59_402756_1 247490.KSU1_D0176 4.82e-40 147.0 COG1943@1|root,COG1943@2|Bacteria,2IYXS@203682|Planctomycetes 203682|Planctomycetes L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_665310_1 983548.Krodi_1555 5.42e-18 85.1 COG2010@1|root,COG2010@2|Bacteria,4NF0A@976|Bacteroidetes,1HXD9@117743|Flavobacteriia,37F00@326319|Dokdonia 976|Bacteroidetes C Cytochrome c7 and related cytochrome c actA - - - - - - - - - - - Cytochrom_C,Cytochrom_CIII,Cytochrome_C7 k59_142688_1 1122197.ATWI01000011_gene250 3.39e-93 287.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,4653S@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the peptidase M20A family. ArgE subfamily argE GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0008777,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_4488 M20_dimer,Peptidase_M20,Peptidase_M28 k59_958340_1 1168034.FH5T_06060 1.29e-112 335.0 COG1066@1|root,COG1066@2|Bacteria,4NEYA@976|Bacteroidetes,2FMRM@200643|Bacteroidia 976|Bacteroidetes O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_42069_1 1168034.FH5T_21960 3.36e-119 344.0 COG0854@1|root,COG0854@2|Bacteria,4NF4Z@976|Bacteroidetes,2FM21@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_42069_2 1168034.FH5T_21955 3.29e-29 110.0 COG0517@1|root,COG0517@2|Bacteria,4NF8G@976|Bacteroidetes,2FT2B@200643|Bacteroidia 976|Bacteroidetes S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_109383_1 999419.HMPREF1077_03136 7.39e-73 226.0 COG1129@1|root,COG1129@2|Bacteria,4PKVD@976|Bacteroidetes,2FM9B@200643|Bacteroidia,22WJ7@171551|Porphyromonadaceae 976|Bacteroidetes G AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_793075_1 580332.Slit_2889 7.49e-12 64.7 arCOG09486@1|root,2ZC3Y@2|Bacteria,1RD8N@1224|Proteobacteria,2VS11@28216|Betaproteobacteria 28216|Betaproteobacteria H PFAM Glycosyl transferase family 11 - - - - - - - - - - - - Glyco_transf_11 k59_793075_2 113395.AXAI01000011_gene6399 5.08e-60 194.0 COG0500@1|root,COG2226@2|Bacteria,1PE78@1224|Proteobacteria,2V82K@28211|Alphaproteobacteria,3K5JW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_566964_1 743299.Acife_2664 1.89e-11 62.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,2NCWP@225057|Acidithiobacillales 225057|Acidithiobacillales H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB k59_566964_2 1121940.AUDZ01000007_gene2313 3.17e-29 116.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1XJFS@135619|Oceanospirillales 135619|Oceanospirillales J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_76536_1 1454004.AW11_02009 1.34e-91 291.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria 28216|Betaproteobacteria P Pfam Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_827924_1 870187.Thini_0534 5.1e-100 301.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,460SY@72273|Thiotrichales 72273|Thiotrichales J PFAM tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_697148_1 1240350.AMZE01000061_gene3356 6e-19 82.8 2ANPA@1|root,31DNS@2|Bacteria,1REM3@1224|Proteobacteria,1SY9Z@1236|Gammaproteobacteria,1YX0K@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Protein of unknown function (DUF3833) - - - - - - - - - - - - DUF3833 k59_434922_1 595460.RRSWK_00674 3.87e-58 195.0 2DBKQ@1|root,2Z9U7@2|Bacteria,2IWVD@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_303977_1 1168034.FH5T_07340 9.94e-141 405.0 COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,2G2SB@200643|Bacteroidia 976|Bacteroidetes V ATPases associated with a variety of cellular activities gldA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_109908_1 1117647.M5M_01585 3.97e-119 357.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1J589@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_729596_1 1121396.KB893038_gene3622 4.93e-107 321.0 2C69V@1|root,2Z9DY@2|Bacteria,1R5H6@1224|Proteobacteria,431UD@68525|delta/epsilon subdivisions,2WX2V@28221|Deltaproteobacteria,2MNTC@213118|Desulfobacterales 1224|Proteobacteria - - - - - - - - - - - - - - - k59_403319_1 1056820.KB900674_gene2558 3.3e-16 84.3 COG0745@1|root,COG0784@1|root,COG5001@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2PQ0D@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_42590_2 1173020.Cha6605_5356 4.24e-149 438.0 COG3666@1|root,COG3666@2|Bacteria,1GEUC@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_109912_1 1437824.BN940_02756 7.45e-79 241.0 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2VQAQ@28216|Betaproteobacteria,3T3MQ@506|Alcaligenaceae 28216|Betaproteobacteria J RNA pseudouridylate synthase rluE - 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_665922_1 1121405.dsmv_3225 8.38e-97 304.0 COG0031@1|root,COG0215@1|root,COG0031@2|Bacteria,COG0215@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,2MIN1@213118|Desulfobacterales 28221|Deltaproteobacteria J cysteinyl-tRNA synthetase cysM - 2.5.1.47,6.1.1.16 ko:K01738,ko:K01883,ko:K12339 ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00359,M00360 R00897,R03132,R03601,R03650,R04859 RC00020,RC00055,RC00523,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,PALP,tRNA-synt_1e k59_42591_1 1166948.JPZL01000003_gene461 1.58e-82 265.0 COG1234@1|root,COG1341@1|root,COG1234@2|Bacteria,COG1341@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Beta-lactamase superfamily domain rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - CLP1_P,Lactamase_B,Lactamase_B_2 k59_567591_1 1249627.D779_1872 4.8e-38 142.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_567591_2 2340.JV46_12700 2.88e-30 118.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1J4PD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_109914_1 1968.JOEV01000025_gene5056 7.3e-19 87.4 COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria 201174|Actinobacteria T response regulator - - - - - - - - - - - - GerE,Response_reg k59_600250_1 944547.ABLL_0958 4.67e-85 251.0 COG2033@1|root,COG2033@2|Bacteria,1NDWH@1224|Proteobacteria,42RSM@68525|delta/epsilon subdivisions,2YP5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Desulfoferrodoxin ferrous iron-binding - - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrodox k59_502726_2 1245469.S58_36120 1.56e-40 146.0 COG0318@1|root,COG0515@1|root,COG0318@2|Bacteria,COG0515@2|Bacteria,1R4X2@1224|Proteobacteria,2TQVY@28211|Alphaproteobacteria,3JU2U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQT serine threonine protein kinase MA20_41400 - - - - - - - - - - - AMP-binding_C k59_992490_1 309807.SRU_0899 7.89e-58 199.0 COG0733@1|root,COG0733@2|Bacteria,4NGQ5@976|Bacteroidetes,1FJPU@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_435518_1 1265313.HRUBRA_01492 1.83e-155 441.0 COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_828523_1 1168034.FH5T_12030 5.3e-83 252.0 COG3279@1|root,COG3279@2|Bacteria,4NEAH@976|Bacteroidetes,2FWA7@200643|Bacteroidia 976|Bacteroidetes T LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_245759_2 1122225.AULQ01000007_gene2366 2.43e-11 65.1 COG0242@1|root,COG0242@2|Bacteria,4NFB4@976|Bacteroidetes,1HX7M@117743|Flavobacteriia 976|Bacteroidetes J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_899706_1 118005.AWNK01000010_gene301 5.49e-78 251.0 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria 2|Bacteria P Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - CusF_Ec,HlyD_D23,HlyD_D4 k59_866395_1 1163617.SCD_n02930 8.95e-105 310.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2VRJN@28216|Betaproteobacteria 28216|Betaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_1029745_2 985255.APHJ01000039_gene174 3.35e-12 64.7 COG1416@1|root,COG1416@2|Bacteria,4NQQE@976|Bacteroidetes,1I35I@117743|Flavobacteriia,2P70P@244698|Gillisia 976|Bacteroidetes S DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_899709_1 999141.GME_00070 4.76e-36 139.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1XHCM@135619|Oceanospirillales 135619|Oceanospirillales T signal-transduction protein containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_834194_1 1408473.JHXO01000010_gene3573 8.31e-59 183.0 COG0537@1|root,COG0537@2|Bacteria,4NQ4X@976|Bacteroidetes,2FSRY@200643|Bacteroidia 976|Bacteroidetes FG Histidine triad domain protein hinT - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_834194_2 1168034.FH5T_04850 1.82e-49 160.0 COG0782@1|root,COG0782@2|Bacteria,4NNH6@976|Bacteroidetes,2FPFU@200643|Bacteroidia 976|Bacteroidetes K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_376843_1 572544.Ilyop_1687 0.0 1078.0 COG0441@1|root,COG0441@2|Bacteria,378FC@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_376843_2 888055.HMPREF9015_00515 1.97e-40 146.0 COG0670@1|root,COG0670@2|Bacteria,379SP@32066|Fusobacteria 32066|Fusobacteria S Belongs to the BI1 family - - - ko:K06890 - - - - ko00000 - - - Bax1-I k59_899712_1 1168034.FH5T_02935 1.08e-149 429.0 COG0657@1|root,COG0657@2|Bacteria,4NNWF@976|Bacteroidetes,2G18S@200643|Bacteroidia 976|Bacteroidetes I Phospholipase/Carboxylesterase - - - - - - - - - - - - Abhydrolase_3,COesterase k59_606286_1 177437.HRM2_02650 2.58e-28 108.0 COG3216@1|root,COG3216@2|Bacteria,1QEG2@1224|Proteobacteria,42VUY@68525|delta/epsilon subdivisions,2WRD1@28221|Deltaproteobacteria,2MM28@213118|Desulfobacterales 28221|Deltaproteobacteria S protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_998258_1 1168034.FH5T_05930 1.91e-217 630.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,2FMH3@200643|Bacteroidia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran,OEP k59_149034_2 983545.Glaag_4274 1.23e-34 130.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,46440@72275|Alteromonadaceae 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_181684_1 314345.SPV1_03033 3.94e-49 165.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria 1224|Proteobacteria T OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_541135_1 572544.Ilyop_1470 4.94e-67 216.0 COG0439@1|root,COG0439@2|Bacteria,379P7@32066|Fusobacteria 32066|Fusobacteria I acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_541135_2 572544.Ilyop_1469 3.77e-16 72.8 COG1302@1|root,COG1302@2|Bacteria,37AEJ@32066|Fusobacteria 32066|Fusobacteria S Asp23 family, cell envelope-related function - - - - - - - - - - - - Asp23 k59_768832_1 1205753.A989_10440 9.01e-27 102.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1X7P3@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional - - - - - - - - - - - - HTH_5 k59_181687_1 1111732.AZOD01000029_gene1533 2.22e-46 169.0 COG3563@1|root,COG3563@2|Bacteria,1MW0T@1224|Proteobacteria,1RPMS@1236|Gammaproteobacteria,1X6E1@135614|Xanthomonadales 135614|Xanthomonadales M Capsule polysaccharide biosynthesis protein - - - ko:K07266 - - - - ko00000 - - - Capsule_synth k59_115424_1 414684.RC1_3175 6.91e-96 304.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TRTE@28211|Alphaproteobacteria 28211|Alphaproteobacteria EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - PD40,Peptidase_S9 k59_703695_1 6412.HelroP159663 9.07e-14 71.2 2DKMB@1|root,2S635@2759|Eukaryota 2759|Eukaryota S 2'-5' RNA ligase superfamily - - - - - - - - - - - - 2_5_RNA_ligase2 k59_834212_1 1265505.ATUG01000002_gene1581 1.04e-51 178.0 COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales 28221|Deltaproteobacteria H Trimethylamine methyltransferase - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_149721_1 857087.Metme_2457 3.13e-93 279.0 COG1733@1|root,COG1733@2|Bacteria,1PGWN@1224|Proteobacteria,1SXVP@1236|Gammaproteobacteria,1XGTB@135618|Methylococcales 135618|Methylococcales K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_246515_1 1168034.FH5T_16860 7.63e-126 371.0 COG2986@1|root,COG2986@2|Bacteria,4NE0D@976|Bacteroidetes,2FMCF@200643|Bacteroidia 976|Bacteroidetes E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_672640_1 945550.VISI1226_00420 7.03e-07 52.4 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1XSE0@135623|Vibrionales 135623|Vibrionales P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_672640_2 1123511.KB905839_gene353 4.29e-97 296.0 COG1653@1|root,COG1653@2|Bacteria,1TS9Z@1239|Firmicutes,4H53C@909932|Negativicutes 909932|Negativicutes G Bacterial extracellular solute-binding protein - - - ko:K17234 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - SBP_bac_1 k59_672642_1 426114.THI_0136 9.47e-36 122.0 COG4451@1|root,COG4451@2|Bacteria,1RIDQ@1224|Proteobacteria,2VSEM@28216|Betaproteobacteria,1KP3Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Ribulose bisphosphate carboxylase, small chain cbbS - 4.1.1.39 ko:K01602 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_small k59_672642_2 426114.THI_0137 2.77e-06 50.4 28IUD@1|root,2Z8T4@2|Bacteria,1QZHS@1224|Proteobacteria,2VK06@28216|Betaproteobacteria 28216|Betaproteobacteria S Carboxysome shell peptide mid-region - - - - - - - - - - - - CsoS2_M k59_1030426_1 1168034.FH5T_07920 1.67e-51 175.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,2FR0X@200643|Bacteroidia 976|Bacteroidetes C Aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 ko:K00128,ko:K00135 ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00027,M00135 R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1030426_2 1168034.FH5T_07910 1.63e-59 186.0 COG1765@1|root,COG1765@2|Bacteria,4NNTY@976|Bacteroidetes,2FU46@200643|Bacteroidia 976|Bacteroidetes O OsmC-like protein - - - ko:K07397 - - - - ko00000 - - - OsmC k59_573968_1 1255043.TVNIR_0217 2.4e-42 142.0 2E4R1@1|root,32ZJK@2|Bacteria,1N8FZ@1224|Proteobacteria,1S42H@1236|Gammaproteobacteria,1WYUX@135613|Chromatiales 135613|Chromatiales S Nitrous oxide-stimulated promoter - - - - - - - - - - - - YgbA_NO k59_672646_1 1453505.JASY01000008_gene948 6.3e-34 124.0 2DNPH@1|root,32YF1@2|Bacteria,4NVUP@976|Bacteroidetes,1IIC9@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_475108_1 398525.KB900701_gene7326 9e-86 278.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,3JSUZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I enoyl-CoA hydratase isomerase MA20_44845 - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_83066_1 1121396.KB892935_gene3840 2.6e-34 135.0 COG0500@1|root,COG4258@1|root,COG0500@2|Bacteria,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,42P70@68525|delta/epsilon subdivisions,2WJGD@28221|Deltaproteobacteria,2MJYG@213118|Desulfobacterales 28221|Deltaproteobacteria Q MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_900431_1 1408438.JADD01000042_gene681 4.84e-13 71.2 COG0151@1|root,COG0151@2|Bacteria,1TRIN@1239|Firmicutes,4ISAR@91061|Bacilli,27F6Z@186827|Aerococcaceae 91061|Bacilli F ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 k59_900431_2 177437.HRM2_14820 3.94e-60 192.0 COG4947@1|root,COG4947@2|Bacteria,1PX2K@1224|Proteobacteria,43890@68525|delta/epsilon subdivisions,2XA2S@28221|Deltaproteobacteria,2MPA5@213118|Desulfobacterales 28221|Deltaproteobacteria S esterase - - - - - - - - - - - - - k59_769588_2 96561.Dole_0600 3.53e-32 119.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MJKI@213118|Desulfobacterales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_900438_1 243233.MCA2596 9.77e-76 231.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1XFYM@135618|Methylococcales 135618|Methylococcales L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_573972_3 756272.Plabr_2921 1.92e-34 121.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase k59_999058_1 1172190.M947_08980 1.31e-22 90.1 2BSRI@1|root,32MUE@2|Bacteria,1Q3E8@1224|Proteobacteria,42X6B@68525|delta/epsilon subdivisions,2YQST@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_999058_2 929558.SMGD1_0336 4.39e-76 240.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2YMTZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iIT341.HP0623 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_116144_1 439235.Dalk_1541 3.26e-85 257.0 COG1878@1|root,COG1878@2|Bacteria,1MV8S@1224|Proteobacteria,42QAR@68525|delta/epsilon subdivisions,2WKBY@28221|Deltaproteobacteria,2MNA0@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM cyclase family protein - - - - - - - - - - - - Cyclase k59_116144_2 742817.HMPREF9449_00792 1.18e-08 54.3 COG1225@1|root,COG1225@2|Bacteria,4NNGK@976|Bacteroidetes,2FNTB@200643|Bacteroidia,22Y01@171551|Porphyromonadaceae 976|Bacteroidetes O Thiol peroxidase bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_509710_1 1254432.SCE1572_15940 6.1e-08 58.9 2DSXQ@1|root,33HVC@2|Bacteria,1N9KU@1224|Proteobacteria 1224|Proteobacteria S Kazal type serine protease inhibitors - - - - - - - - - - - - Kazal_1,Kazal_2 k59_214927_1 765910.MARPU_00140 1.75e-99 310.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_377521_2 1249480.B649_05640 2.63e-96 289.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2YPQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Transposase - - - - - - - - - - - - Y1_Tnp k59_214929_1 1122915.AUGY01000085_gene6143 8.4e-111 342.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_3,HATPase_c,HTH_8,HisKA,Hpt,PAS_4,Response_reg k59_311268_1 13333.ERN11805 4.18e-116 370.0 2CMQD@1|root,2QRDV@2759|Eukaryota,37QIN@33090|Viridiplantae,3GEA1@35493|Streptophyta 35493|Streptophyta S function. Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis ycf2 - - - - - - - - - - - AAA,DUF825 k59_246542_1 1122947.FR7_2028 1.73e-75 236.0 COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,4H1WA@909932|Negativicutes 909932|Negativicutes H Molybdopterin binding domain protein - - - - - - - - - - - - MoCF_biosynth k59_798970_2 323261.Noc_1323 2.24e-33 130.0 2DBYQ@1|root,32TYF@2|Bacteria,1N2HM@1224|Proteobacteria,1SB6Y@1236|Gammaproteobacteria,1X1T1@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_900453_1 1499967.BAYZ01000095_gene4289 1.93e-36 128.0 COG3760@1|root,COG3760@2|Bacteria 2|Bacteria S aminoacyl-tRNA metabolism involved in translational fidelity proX - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_182371_1 572544.Ilyop_0363 3.15e-96 291.0 COG0342@1|root,COG0342@2|Bacteria,3791U@32066|Fusobacteria 32066|Fusobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_769608_1 472759.Nhal_1070 4.58e-90 280.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_214944_1 484770.UFO1_3168 7.87e-64 208.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,4H3IS@909932|Negativicutes 909932|Negativicutes C alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_48716_1 536019.Mesop_5914 1.39e-107 321.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,43IEZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Aminotransferase phnW - 2.6.1.37 ko:K03430 ko00440,ko01100,ko01120,map00440,map01100,map01120 - R04152 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_5 k59_1030471_1 1168034.FH5T_18230 4.56e-59 196.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,2FNCD@200643|Bacteroidia 976|Bacteroidetes I Carboxyl transferase domain protein - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_182380_1 1123368.AUIS01000005_gene483 1.14e-71 228.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,2NBWP@225057|Acidithiobacillales 225057|Acidithiobacillales C 4Fe-4S dicluster domain glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7 k59_965798_1 631362.Thi970DRAFT_00980 1.01e-93 284.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1WWXZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_735907_1 1196324.A374_19280 6.99e-33 119.0 COG2363@1|root,COG2363@2|Bacteria,1VA79@1239|Firmicutes,4HKHG@91061|Bacilli 91061|Bacilli S membrane ywdK - - - - - - - - - - - DUF423 k59_1030476_2 929558.SMGD1_2439 9.06e-36 129.0 COG4649@1|root,COG4649@2|Bacteria,1Q2HI@1224|Proteobacteria,42VQJ@68525|delta/epsilon subdivisions,2YQ7B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - TPR_21 k59_149807_1 998674.ATTE01000001_gene4508 9.16e-54 181.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,4603E@72273|Thiotrichales 72273|Thiotrichales E Cys/Met metabolism PLP-dependent enzyme - - 2.6.1.88 ko:K14287 - - R08618 RC00006,RC00025 ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_149807_2 1356852.N008_10465 1.41e-39 140.0 COG0388@1|root,COG0388@2|Bacteria,4NE37@976|Bacteroidetes,47JPF@768503|Cytophagia 976|Bacteroidetes S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase yafV - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_607049_1 1168034.FH5T_00085 3.85e-42 145.0 COG0561@1|root,COG0561@2|Bacteria 2|Bacteria Q phosphatase activity ybhA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033883,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050308 - - - - - - - - - iECSP_1301.ECSP_0819,iECs_1301.ECs0794,iG2583_1286.G2583_0932,iZ_1308.Z0936 Hydrolase_3 k59_475156_1 1500304.JQKY01000027_gene1270 1.01e-72 233.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,4B93D@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_999107_1 933262.AXAM01000015_gene70 1.68e-25 98.2 COG4113@1|root,COG4113@2|Bacteria,1N96B@1224|Proteobacteria,42TZ7@68525|delta/epsilon subdivisions,2WR0Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_999107_2 933262.AXAM01000015_gene71 7.4e-30 107.0 COG4118@1|root,COG4118@2|Bacteria,1Q43S@1224|Proteobacteria,42VPT@68525|delta/epsilon subdivisions,2WS3C@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Antitoxin Phd_YefM, type II toxin-antitoxin system - - - - - - - - - - - - PhdYeFM_antitox k59_1030484_1 767434.Fraau_0854 5.71e-83 267.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1X4F7@135614|Xanthomonadales 135614|Xanthomonadales D Cell division protein ftsk ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - Cupin_4,FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_346258_2 243365.CV_4124 3.35e-23 97.1 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,2KPVW@206351|Neisseriales 206351|Neisseriales E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.98 ko:K13017 ko00520,map00520 - R10141 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_704394_1 1121035.AUCH01000004_gene429 7.85e-74 253.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_704394_2 1367491.BN865_08550c 0.000373 42.4 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2YMCD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN2 - - - - - - - - - - - Radical_SAM k59_12685_1 1388763.O165_010170 3.58e-56 189.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,1YX9S@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Flavin containing amine oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_835013_1 1501230.ET33_22710 3.29e-56 198.0 COG2227@1|root,COG3321@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins - - - ko:K13612 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_116193_1 314275.MADE_1005825 4.38e-57 192.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,465EU@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_509754_1 768671.ThimaDRAFT_0909 6.47e-135 389.0 COG1131@1|root,COG1131@2|Bacteria,1R3XF@1224|Proteobacteria,1S0MM@1236|Gammaproteobacteria 1236|Gammaproteobacteria V abc transporter atp-binding protein nodI - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1036161_3 1537917.JU82_01130 4.32e-62 199.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2YME5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_579550_1 1267533.KB906737_gene1660 1.54e-10 69.7 COG4447@1|root,COG4447@2|Bacteria,3Y4ZQ@57723|Acidobacteria,2JJE3@204432|Acidobacteriia 204432|Acidobacteriia S cellulose binding - - - - - - - - - - - - - k59_741637_2 1049564.TevJSym_ad00300 2.77e-118 353.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J90E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Proton-conducting membrane transporter - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_89263_1 1298867.AUES01000042_gene3559 5.58e-23 97.1 COG0845@1|root,COG0845@2|Bacteria,1RC4B@1224|Proteobacteria,2U65Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_775519_2 748247.AZKH_2964 1.62e-58 205.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4 k59_283615_1 1349822.NSB1T_00890 9.13e-60 208.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,2FM8X@200643|Bacteroidia,22WNP@171551|Porphyromonadaceae 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_579553_1 1122197.ATWI01000012_gene718 2.95e-09 62.4 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,465SW@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0810 Periplasmic protein TonB, links inner and outer membranes tonB3 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_547464_2 944547.ABLL_1323 0.0 927.0 COG0419@1|root,COG0419@2|Bacteria,1R5QS@1224|Proteobacteria,42USI@68525|delta/epsilon subdivisions 1224|Proteobacteria L Protein of unknown function (DUF3732) - - - - - - - - - - - - DUF3732 k59_383388_2 998674.ATTE01000001_gene2707 1.02e-59 192.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,45ZWI@72273|Thiotrichales 72273|Thiotrichales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_480866_1 709032.Sulku_0132 4.37e-45 160.0 COG4773@1|root,COG4773@2|Bacteria,1QZMX@1224|Proteobacteria,42SA0@68525|delta/epsilon subdivisions,2YPCD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - - k59_480866_2 929558.SMGD1_1792 4.07e-89 271.0 COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2YMX1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter permease nikY - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_775523_1 1283300.ATXB01000001_gene610 3.04e-132 396.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XDNZ@135618|Methylococcales 135618|Methylococcales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_971788_1 102129.Lepto7375DRAFT_7801 4.68e-46 163.0 COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1H97S@1150|Oscillatoriales 1117|Cyanobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_547473_1 56780.SYN_01747 8.31e-71 228.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MR03@213462|Syntrophobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_906410_1 1168034.FH5T_07350 6.04e-142 410.0 COG0192@1|root,COG0192@2|Bacteria,4NG7Y@976|Bacteroidetes,2FNW8@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_775527_1 472759.Nhal_2664 5.42e-65 209.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1WWFW@135613|Chromatiales 135613|Chromatiales P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_971794_1 1408473.JHXO01000012_gene463 3.8e-51 184.0 COG2982@1|root,COG2982@2|Bacteria,4P1IY@976|Bacteroidetes 976|Bacteroidetes M AsmA-like C-terminal region - - - - - - - - - - - - AsmA_2 k59_1036192_2 1192124.LIG30_2515 1.19e-33 126.0 COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VRQ8@28216|Betaproteobacteria,1K3QP@119060|Burkholderiaceae 28216|Betaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - Trehalose_PPase k59_415561_1 387093.SUN_0360 1.68e-40 139.0 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,42MHJ@68525|delta/epsilon subdivisions,2YMM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S dinuclear metal center protein, YbgI - - 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - NIF3 k59_415561_2 387093.SUN_0359 1.23e-65 207.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2YMQ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_220714_1 96561.Dole_0075 9.77e-44 156.0 COG4770@1|root,COG5016@1|root,COG4770@2|Bacteria,COG5016@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria,2MHKV@213118|Desulfobacterales 28221|Deltaproteobacteria CI Conserved carboxylase domain - - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_220714_3 1232437.KL662077_gene1866 2.73e-115 344.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MIPI@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM carboxyl transferase - - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_804876_1 1219065.VPR01S_06_01950 3.26e-34 128.0 COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,1SASV@1236|Gammaproteobacteria,1XW7S@135623|Vibrionales 135623|Vibrionales O DSBA-like thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 k59_804876_2 331869.BAL199_15983 1.69e-26 100.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,4BQ52@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily gloA GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_710380_1 944547.ABLL_1495 1.13e-39 144.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42QFD@68525|delta/epsilon subdivisions,2YND7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FP Ppx GppA - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_1036198_1 2340.JV46_16340 7.68e-86 277.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1J4YE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_480876_1 981384.AEYW01000001_gene1602 1.27e-114 346.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_122240_1 96561.Dole_0186 2.65e-12 66.6 COG0789@1|root,COG0789@2|Bacteria,1N7M7@1224|Proteobacteria,42WAT@68525|delta/epsilon subdivisions,2WRPH@28221|Deltaproteobacteria,2MMFX@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM regulatory protein MerR - - - - - - - - - - - - MerR_1 k59_122240_2 96561.Dole_1470 3.51e-40 149.0 COG0457@1|root,COG2203@1|root,COG2204@1|root,COG0457@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BR8@68525|delta/epsilon subdivisions,2X724@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Sigma54_activat k59_840837_1 1123277.KB893197_gene6105 2.16e-37 145.0 COG1520@1|root,COG3266@1|root,COG1520@2|Bacteria,COG3266@2|Bacteria,4NQBS@976|Bacteroidetes,47QPM@768503|Cytophagia 976|Bacteroidetes S FG-GAP repeat - - - - - - - - - - - - FG-GAP_2 k59_18747_1 400668.Mmwyl1_1447 1.96e-16 79.7 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH3T@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_18747_2 1121403.AUCV01000003_gene1716 1.83e-113 330.0 COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,42QH5@68525|delta/epsilon subdivisions,2WMMF@28221|Deltaproteobacteria,2MK0S@213118|Desulfobacterales 28221|Deltaproteobacteria T Transcriptional regulatory protein, C terminal colR - - - - - - - - - - - Response_reg,Trans_reg_C k59_18747_3 1249627.D779_4020 3.23e-19 87.4 COG0642@1|root,COG0642@2|Bacteria,1R54C@1224|Proteobacteria,1RNTM@1236|Gammaproteobacteria,1X29B@135613|Chromatiales 135613|Chromatiales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HisKA k59_1036207_2 502025.Hoch_5432 7.45e-44 149.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,2YVG1@29|Myxococcales 28221|Deltaproteobacteria L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_645605_1 1245471.PCA10_32790 7.95e-13 73.6 COG3203@1|root,COG3203@2|Bacteria,1MWEA@1224|Proteobacteria,1RXX8@1236|Gammaproteobacteria,1YDHK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_351990_1 1267535.KB906767_gene3093 1.44e-12 74.7 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,HEAT_PBS k59_89307_2 984262.SGRA_3214 1.99e-14 79.7 COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,4NMVU@976|Bacteroidetes 976|Bacteroidetes KT Histidine kinase-like ATPase domain - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HATPase_c_2,SpoIIE k59_448052_2 913325.N799_03690 4.81e-73 225.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1X340@135614|Xanthomonadales 135614|Xanthomonadales L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_840849_1 261292.Nit79A3_0568 1.46e-25 100.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,372DD@32003|Nitrosomonadales 28216|Betaproteobacteria K Belongs to the UPF0301 (AlgH) family algH - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_840849_2 317025.Tcr_1828 9e-30 110.0 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,46139@72273|Thiotrichales 72273|Thiotrichales L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_317047_1 207559.Dde_2480 0.000202 43.5 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2M7YC@213115|Desulfovibrionales 28221|Deltaproteobacteria L DEAD DEAH box helicase domain protein rhlE-2 - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_155768_1 132113.XP_003493939.1 4.62e-67 228.0 COG0187@1|root,KOG0355@2759|Eukaryota,38CPA@33154|Opisthokonta,3BFVW@33208|Metazoa,3CW22@33213|Bilateria,41X4Y@6656|Arthropoda,3SGDZ@50557|Insecta,46GTI@7399|Hymenoptera 33208|Metazoa B Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks - - - - - - - - - - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,SMC_N,Toprim k59_383440_1 1442599.JAAN01000031_gene1435 3.62e-29 117.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1X31Z@135614|Xanthomonadales 135614|Xanthomonadales S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_775557_1 929556.Solca_2851 1.25e-05 52.4 COG0236@1|root,COG0236@2|Bacteria,4PNV3@976|Bacteroidetes,1J0TW@117747|Sphingobacteriia 976|Bacteroidetes IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - - - - - - - - - - - k59_18763_1 713586.KB900536_gene3059 2.44e-86 270.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales 135613|Chromatiales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_383443_1 1265505.ATUG01000001_gene3492 7.99e-41 154.0 COG0784@1|root,COG2202@1|root,COG4191@1|root,COG4936@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHWA@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,Response_reg k59_579599_1 595460.RRSWK_06783 5.29e-66 223.0 COG2304@1|root,COG2304@2|Bacteria,2IY1T@203682|Planctomycetes 203682|Planctomycetes S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA,VWA_3 k59_971828_1 1410653.JHVC01000001_gene1666 9.68e-94 290.0 COG0477@1|root,COG0477@2|Bacteria,1UNMW@1239|Firmicutes,25ECT@186801|Clostridia,36UWC@31979|Clostridiaceae 186801|Clostridia EGP TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_1036244_1 1537917.JU82_05660 1.31e-46 159.0 COG0697@1|root,COG0697@2|Bacteria,1R8RU@1224|Proteobacteria,42SDJ@68525|delta/epsilon subdivisions,2YPDW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_383458_1 1185652.USDA257_c30650 8.29e-46 163.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2U0TP@28211|Alphaproteobacteria,4BBQV@82115|Rhizobiaceae 28211|Alphaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_741692_1 270374.MELB17_20011 2.04e-56 184.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,465AA@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the peptidase S33 family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_972295_1 879212.DespoDRAFT_03480 9.33e-112 333.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,2MHSU@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_122860_1 706587.Desti_1547 1.21e-17 84.3 COG1309@1|root,COG1309@2|Bacteria,1QENQ@1224|Proteobacteria,42TNJ@68525|delta/epsilon subdivisions,2WR2U@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Bacterial transcriptional repressor C-terminal - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_906959_1 1123073.KB899241_gene2109 1.78e-09 64.3 COG1879@1|root,COG2374@1|root,COG1879@2|Bacteria,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RRGN@1236|Gammaproteobacteria,1X3H2@135614|Xanthomonadales 135614|Xanthomonadales Q Lamin Tail Domain - - - - - - - - - - - - Calx-beta,LTD k59_580423_1 1203190.CAJP01000034_gene1290 1.95e-48 174.0 COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,2HGIS@201174|Actinobacteria,22JPZ@1653|Corynebacteriaceae 201174|Actinobacteria S MMPL family - - - ko:K06994 - - - - ko00000 - - - MMPL k59_221360_1 519989.ECTPHS_03577 9.09e-63 213.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales 135613|Chromatiales L Helicase - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2 k59_253187_1 1384056.N787_06560 3.92e-05 49.3 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RRQE@1236|Gammaproteobacteria,1X7AT@135614|Xanthomonadales 135614|Xanthomonadales EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh_C k59_253187_2 1283300.ATXB01000001_gene585 4.75e-13 67.4 COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1XFCP@135618|Methylococcales 135618|Methylococcales N Protein required for attachment to host cells - - - - - - - - - - - - Host_attach k59_805527_1 1178825.ALIH01000002_gene946 7.69e-49 177.0 COG0574@1|root,COG0574@2|Bacteria,4NH4R@976|Bacteroidetes,1HWKY@117743|Flavobacteriia 976|Bacteroidetes G Pyruvate phosphate dikinase - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_284230_1 153721.MYP_5011 5.16e-39 162.0 COG0358@1|root,COG0630@1|root,COG0358@2|Bacteria,COG0630@2|Bacteria,4NI2W@976|Bacteroidetes,47NGY@768503|Cytophagia 976|Bacteroidetes LNU type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_516709_1 1349822.NSB1T_09630 1.42e-12 68.6 COG2859@1|root,COG2859@2|Bacteria,4NI76@976|Bacteroidetes,2FP2Q@200643|Bacteroidia,231GV@171551|Porphyromonadaceae 976|Bacteroidetes S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL k59_580431_1 1384056.N787_00965 9.32e-51 176.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria,1X3XX@135614|Xanthomonadales 135614|Xanthomonadales C Methylmalonate-semialdehyde dehydrogenase - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_189045_1 1249627.D779_1891 2.17e-63 217.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_711090_1 1165841.SULAR_06293 2.82e-77 244.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2YNJC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_253200_1 717773.Thicy_1386 9.91e-24 92.0 COG1396@1|root,COG1396@2|Bacteria,1NNTN@1224|Proteobacteria,1SIW9@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_580439_1 1165841.SULAR_08352 6.03e-116 343.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2YMZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_55172_1 1168034.FH5T_12460 1.3e-111 335.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,4NEXG@976|Bacteroidetes,2G2WR@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_55172_2 1168034.FH5T_12465 7.88e-66 206.0 COG0664@1|root,COG0664@2|Bacteria,4NFB1@976|Bacteroidetes,2FNHP@200643|Bacteroidia 976|Bacteroidetes K Cyclic nucleotide-binding domain protein - - - ko:K21556 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_416155_3 749222.Nitsa_1045 2.82e-94 283.0 COG1583@1|root,COG1583@2|Bacteria,1PDGE@1224|Proteobacteria,42QC7@68525|delta/epsilon subdivisions,2YNQ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L CRISPR associated protein Cas6 cas6 - - - - - - - - - - - Cas_Cas6 k59_416155_4 749222.Nitsa_1048 4.6e-132 397.0 2AHY5@1|root,318B7@2|Bacteria,1Q03V@1224|Proteobacteria,42PEM@68525|delta/epsilon subdivisions,2YNPX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - cas8 - - ko:K19114 - - - - ko00000,ko02048 - - - Cas_TM1802 k59_679401_4 340177.Cag_0982 8.78e-121 386.0 COG0189@1|root,COG0318@1|root,COG0189@2|Bacteria,COG0318@2|Bacteria,1FDCE@1090|Chlorobi 1090|Chlorobi F ATP-grasp domain - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,CPSase_L_D2,RimK k59_322300_2 1195246.AGRI_04461 7.71e-06 55.1 COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,1S1ZR@1236|Gammaproteobacteria,46766@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2199 FOG GGDEF domain - - - - - - - - - - - - CHASE3,GAF_2,GGDEF,HAMP k59_846592_1 326298.Suden_0274 1.42e-112 331.0 COG0348@1|root,COG0348@2|Bacteria,1Q4BA@1224|Proteobacteria,42Q02@68525|delta/epsilon subdivisions 1224|Proteobacteria C 4Fe-4S ferredoxin - - - - - - - - - - - - Fer4_10,Fer4_5,Fer4_9 k59_390843_1 1165841.SULAR_07795 1.72e-67 220.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42MYT@68525|delta/epsilon subdivisions,2YMKP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_554375_1 879308.HMPREF9130_1635 3.9e-06 56.2 COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,22G6G@1570339|Peptoniphilaceae 186801|Clostridia D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_554375_2 985665.HPL003_07495 1.23e-32 129.0 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,26QJZ@186822|Paenibacillaceae 91061|Bacilli L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_128150_1 95619.PM1_0219505 2.05e-09 59.3 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria 1236|Gammaproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_128150_2 1049564.TevJSym_aw00530 7.67e-85 261.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria,1J68A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_322318_2 1121949.AQXT01000002_gene2151 4.68e-43 156.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,43WIX@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_128164_1 574966.KB898653_gene1411 2.82e-30 114.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1XK0E@135619|Oceanospirillales 135619|Oceanospirillales Q TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - - - - - - - - - - DctQ k59_128164_2 414684.RC1_1476 6.02e-19 86.7 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,2JQE2@204441|Rhodospirillales 204441|Rhodospirillales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_554386_1 709032.Sulku_1143 9.9e-33 128.0 COG1629@1|root,COG4771@2|Bacteria,1MXY7@1224|Proteobacteria,42MSN@68525|delta/epsilon subdivisions,2YN7D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_945818_1 999141.GME_05830 5.98e-44 144.0 COG4115@1|root,COG4115@2|Bacteria,1N0WH@1224|Proteobacteria,1S8ZF@1236|Gammaproteobacteria,1XPT0@135619|Oceanospirillales 135619|Oceanospirillales S YoeB-like toxin of bacterial type II toxin-antitoxin system - - - - - - - - - - - - YoeB_toxin k59_945818_2 2340.JV46_25680 1.72e-92 279.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1J4JS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024 LYTB k59_554387_1 504472.Slin_6228 2.03e-07 57.8 COG0702@1|root,COG0702@2|Bacteria,4NHWV@976|Bacteroidetes,47JMI@768503|Cytophagia 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_128170_1 1165841.SULAR_07675 1.34e-130 389.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_879587_1 886882.PPSC2_c3391 5.86e-89 292.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_128797_1 720554.Clocl_0612 4.6e-05 47.4 COG1595@1|root,COG1595@2|Bacteria,1V7WA@1239|Firmicutes,24JGB@186801|Clostridia,3WRUC@541000|Ruminococcaceae 186801|Clostridia K Sigma-70, region 4 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_128797_2 1163409.UUA_12635 1.81e-12 67.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria,1X3CG@135614|Xanthomonadales 135614|Xanthomonadales S N-acyl-L-amino acid amidohydrolase amaA - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_1011309_1 1122931.AUAE01000010_gene4455 2.4e-80 266.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,2FQUJ@200643|Bacteroidia,22VWA@171551|Porphyromonadaceae 976|Bacteroidetes P AcrB/AcrD/AcrF family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_486908_1 436717.AOLE_08915 2.32e-42 152.0 COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,1RNQ5@1236|Gammaproteobacteria,3NMPR@468|Moraxellaceae 1236|Gammaproteobacteria E GMC oxidoreductase - - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_290249_1 907348.TresaDRAFT_1314 6.27e-60 200.0 COG3177@1|root,COG3177@2|Bacteria,2J7QI@203691|Spirochaetes 203691|Spirochaetes S filamentation induced by cAMP - - - - - - - - - - - - DUF4172,Fic k59_391415_1 102125.Xen7305DRAFT_00046310 1.53e-19 90.5 COG0840@1|root,2Z8BY@2|Bacteria,1G4NC@1117|Cyanobacteria 1117|Cyanobacteria NT Methyl-accepting Chemotaxis protein - - - - - - - - - - - - - k59_879607_1 143224.JQMD01000002_gene1615 1.26e-91 282.0 COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,1HX8I@117743|Flavobacteriia 976|Bacteroidetes P Arylsulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_685601_1 1433126.BN938_1286 2.17e-99 298.0 COG0050@1|root,COG0050@2|Bacteria,4NEWS@976|Bacteroidetes,2FKZA@200643|Bacteroidia,22UC0@171550|Rikenellaceae 976|Bacteroidetes J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_879621_1 469617.FUAG_01629 6.3e-89 271.0 COG0451@1|root,COG0451@2|Bacteria,379AQ@32066|Fusobacteria 32066|Fusobacteria M Polysaccharide biosynthesis protein - - 4.2.1.45 ko:K01709 ko00520,map00520 - R02426 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_912629_1 1454004.AW11_03580 5.12e-72 234.0 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria 28216|Betaproteobacteria S Phospholipase, patatin family - - - ko:K07001 - - - - ko00000 - - - Patatin k59_811675_1 243233.MCA0843 7.51e-34 125.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1XF9M@135618|Methylococcales 135618|Methylococcales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain - - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_811675_2 592015.HMPREF1705_00090 1.82e-23 93.6 COG0494@1|root,COG0494@2|Bacteria 2|Bacteria L nUDIX hydrolase mutT - 3.6.1.13,3.6.1.17,5.3.1.16 ko:K01515,ko:K01518,ko:K01814 ko00230,ko00240,ko00340,ko01100,ko01110,ko01230,map00230,map00240,map00340,map01100,map01110,map01230 M00026 R00184,R00969,R01054,R01232,R02805,R04640 RC00002,RC00945 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_358407_1 1121859.KB890756_gene1421 4.88e-150 433.0 COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria,4PKSV@976|Bacteroidetes,47K5G@768503|Cytophagia 976|Bacteroidetes G BNR repeat-like domain - - - - - - - - - - - - BNR_2 k59_811681_1 933262.AXAM01000040_gene1232 4.31e-58 201.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_227582_1 998674.ATTE01000001_gene1313 1.92e-35 129.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,460N1@72273|Thiotrichales 72273|Thiotrichales BQ PFAM Histone deacetylase - - - - - - - - - - - - Hist_deacetyl k59_227582_2 1038862.KB893844_gene220 0.000572 43.5 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2TUV9@28211|Alphaproteobacteria,3JV4I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_95738_1 1395516.PMO01_20445 1.99e-67 217.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria 1236|Gammaproteobacteria E belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_782448_1 387093.SUN_0581 9.04e-33 118.0 COG1014@1|root,COG1014@2|Bacteria,1R8XG@1224|Proteobacteria,42NPD@68525|delta/epsilon subdivisions,2YMM0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C oxidoreductase oorC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_323067_1 572544.Ilyop_0154 7.86e-29 114.0 COG0659@1|root,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity bicA - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,STAS_2,Sulfate_transp k59_323067_2 572544.Ilyop_0155 9.23e-188 528.0 COG0533@1|root,COG0533@2|Bacteria,3788K@32066|Fusobacteria 32066|Fusobacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_195380_1 696281.Desru_0759 6.17e-14 70.5 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,260EI@186807|Peptococcaceae 186801|Clostridia E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_195380_2 933262.AXAM01000031_gene3006 6.43e-85 259.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MIG5@213118|Desulfobacterales 28221|Deltaproteobacteria E Bacterial transferase hexapeptide (six repeats) cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_456229_1 749222.Nitsa_1674 2.64e-83 273.0 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_61650_1 1345695.CLSA_c39560 6.75e-26 109.0 COG0037@1|root,COG0037@2|Bacteria,1V1S0@1239|Firmicutes,24BSC@186801|Clostridia,36GC2@31979|Clostridiaceae 186801|Clostridia D tRNA processing - - - - - - - - - - - - - k59_61650_2 584708.Apau_1082 5.66e-25 99.8 COG4123@1|root,COG4123@2|Bacteria 2|Bacteria AJ Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_978313_1 1105367.CG50_12195 4.99e-111 322.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT phosphate regulon transcriptional regulatory protein PhoB phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_456233_1 929558.SMGD1_2089 1.48e-96 290.0 2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,42QE2@68525|delta/epsilon subdivisions,2YNKM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S 5'-nucleotidase - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5-nucleotidase k59_421821_1 1158165.KB898875_gene153 1.66e-10 60.5 COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_421821_2 582899.Hden_0695 1.78e-47 157.0 2AKRU@1|root,31BIQ@2|Bacteria,1Q7DM@1224|Proteobacteria,2UEKS@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_847119_1 1279009.ADICEAN_03711 4.96e-52 175.0 2DMY6@1|root,32UCD@2|Bacteria,4NVHX@976|Bacteroidetes,47SQF@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_522944_1 497964.CfE428DRAFT_3817 5.1e-57 193.0 COG1690@1|root,COG1690@2|Bacteria,46SU0@74201|Verrucomicrobia 74201|Verrucomicrobia S tRNA-splicing ligase RtcB - - - - - - - - - - - - RtcB k59_95756_1 1380394.JADL01000003_gene5176 1.73e-46 165.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria,2JPFT@204441|Rhodospirillales 204441|Rhodospirillales S Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_128886_1 485918.Cpin_0475 1.05e-05 47.4 COG0696@1|root,COG0696@2|Bacteria,4NEQT@976|Bacteroidetes,1INQA@117747|Sphingobacteriia 976|Bacteroidetes G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_128886_2 1121405.dsmv_3216 8.76e-54 176.0 2ARUS@1|root,31H6C@2|Bacteria,1RFAK@1224|Proteobacteria,42RXP@68525|delta/epsilon subdivisions,2WNXF@28221|Deltaproteobacteria,2MK37@213118|Desulfobacterales 28221|Deltaproteobacteria S Type I restriction enzyme R protein N terminus (HSDR_N) - - - - - - - - - - - - HSDR_N_2 k59_879687_1 525257.HMPREF0204_10651 3.57e-16 84.3 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1HWYV@117743|Flavobacteriia,3ZQHA@59732|Chryseobacterium 976|Bacteroidetes P membrane - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_555087_1 338966.Ppro_2249 9.74e-110 327.0 COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,42MJI@68525|delta/epsilon subdivisions,2WJQP@28221|Deltaproteobacteria,43UD6@69541|Desulfuromonadales 28221|Deltaproteobacteria C 6-phosphogluconate dehydrogenase, C-terminal domain gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2620 6PGD,NAD_binding_2 k59_195412_1 1191523.MROS_1503 9.96e-54 172.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,DUF4437 k59_25561_2 196162.Noca_2442 6.26e-31 125.0 COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4DN9I@85009|Propionibacteriales 201174|Actinobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_879696_1 1122135.KB893134_gene3970 3.6e-58 204.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Major facilitator Superfamily aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_555094_1 1283299.AUKG01000003_gene234 2.14e-19 90.1 COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4CR35@84995|Rubrobacteria 84995|Rubrobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_456260_1 1168034.FH5T_04160 2.33e-105 311.0 COG2086@1|root,COG2086@2|Bacteria,4NFWB@976|Bacteroidetes,2FMG3@200643|Bacteroidia 976|Bacteroidetes C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_195416_1 1123354.AUDR01000014_gene1015 1.97e-87 272.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,1KRGD@119069|Hydrogenophilales 119069|Hydrogenophilales M NlpB/DapX lipoprotein - - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_128916_1 1121374.KB891588_gene3347 1.09e-130 384.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_1778,iPC815.YPO3335 Fumerase,Fumerase_C k59_391462_1 563040.Saut_0702 1.5e-11 60.8 COG0858@1|root,COG0858@2|Bacteria,1Q48R@1224|Proteobacteria,42UQE@68525|delta/epsilon subdivisions,2YPZY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_391462_2 1537917.JU82_06760 3.79e-66 204.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,42THF@68525|delta/epsilon subdivisions,2YPXJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_391462_3 1172190.M947_09815 3e-14 72.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2YMPP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H riboflavin biosynthesis protein ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_879707_1 1333507.AUTQ01000140_gene2802 5.28e-44 152.0 COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,1T1SF@1236|Gammaproteobacteria,2PZNR@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Conserved TM helix mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_879707_2 1198232.CYCME_0127 3.23e-52 165.0 COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,1S688@1236|Gammaproteobacteria,460V9@72273|Thiotrichales 72273|Thiotrichales S Evidence 4 Homologs of previously reported genes of - - - ko:K09700 - - - - ko00000 - - - - k59_847132_1 396588.Tgr7_3287 1.73e-31 125.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1WX4I@135613|Chromatiales 135613|Chromatiales D PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_227659_1 90814.KL370891_gene1810 3.49e-60 199.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,461KC@72273|Thiotrichales 72273|Thiotrichales J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_227659_2 2340.JV46_21610 5.96e-17 79.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1J4WK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_557225_1 709032.Sulku_2321 2.05e-49 165.0 COG4121@1|root,COG4121@2|Bacteria,1Q8T8@1224|Proteobacteria,42RAP@68525|delta/epsilon subdivisions,2YP3B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_30 k59_164974_2 326298.Suden_0461 6.4e-170 479.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2YN8M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_981938_1 1229276.DI53_2400 1.22e-100 305.0 COG0015@1|root,COG0015@2|Bacteria,4NFY8@976|Bacteroidetes,1IPIU@117747|Sphingobacteriia 976|Bacteroidetes F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,ASL_C,Lyase_1 k59_328402_1 1168034.FH5T_13075 2.59e-179 507.0 COG3579@1|root,COG3579@2|Bacteria,4NE02@976|Bacteroidetes,2FN7G@200643|Bacteroidia 976|Bacteroidetes E Peptidase C1-like family pepC - 3.4.22.40 ko:K01372 - - - - ko00000,ko01000,ko01002 - - - Peptidase_C1,Peptidase_C1_2 k59_851396_1 158190.SpiGrapes_0922 1.4e-26 106.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlA - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_851396_2 177437.HRM2_13230 7.67e-63 209.0 COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,2MHWK@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_851396_3 530564.Psta_3376 4.91e-32 126.0 COG0454@1|root,COG1181@1|root,COG0456@2|Bacteria,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes 203682|Planctomycetes F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_851396_4 871968.DESME_02350 1.01e-47 159.0 COG1011@1|root,COG1011@2|Bacteria 2|Bacteria S phosphatase activity - - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_851396_5 880070.Cycma_4168 5.33e-51 192.0 COG0642@1|root,COG2205@2|Bacteria,4NQ7H@976|Bacteroidetes,47QVS@768503|Cytophagia 976|Bacteroidetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA k59_851396_6 556263.FSEG_00618 1.26e-178 510.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,378MC@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_851396_7 469616.FMAG_00193 1.44e-95 283.0 COG0307@1|root,COG0307@2|Bacteria,37993@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_981942_1 1123392.AQWL01000001_gene1320 4.14e-112 353.0 COG1474@1|root,COG1474@2|Bacteria,1R5I2@1224|Proteobacteria,2VMXQ@28216|Betaproteobacteria 28216|Betaproteobacteria LO Belongs to the peptidase S16 family - - - - - - - - - - - - - k59_949398_1 640081.Dsui_0930 2.38e-47 166.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQS@28216|Betaproteobacteria,2KVUJ@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,PAS_4,Sigma54_activat k59_557239_2 565045.NOR51B_2316 3.47e-30 109.0 COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,1S8V9@1236|Gammaproteobacteria,1J6YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane - - - - - - - - - - - - DUF4212 k59_557242_1 929703.KE386491_gene4025 2.02e-53 186.0 COG1524@1|root,COG1524@2|Bacteria,4NE94@976|Bacteroidetes,47JP2@768503|Cytophagia 976|Bacteroidetes P type I phosphodiesterase nucleotide pyrophosphatase pafA GO:0003674,GO:0003824,GO:0004035,GO:0004346,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0050308,GO:0050309,GO:0098519 - - - - - - - - - - Phosphodiest k59_328413_1 1408473.JHXO01000008_gene2911 1.32e-104 313.0 COG4289@1|root,COG4289@2|Bacteria,4NEU3@976|Bacteroidetes,2G2NU@200643|Bacteroidia 976|Bacteroidetes O protein conserved in bacteria - - - - - - - - - - - - DUF2264,Glyco_hydro_88 k59_328413_2 1168034.FH5T_00975 9.86e-106 317.0 COG4225@1|root,COG4225@2|Bacteria,4NDYS@976|Bacteroidetes,2FM61@200643|Bacteroidia 976|Bacteroidetes G Glycosyl Hydrolase Family 88 - - - - - - - - - - - - Glyco_hydro_88 k59_949403_1 1232410.KI421421_gene3409 9.36e-13 73.6 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,42N14@68525|delta/epsilon subdivisions,2WIKT@28221|Deltaproteobacteria,43SHF@69541|Desulfuromonadales 28221|Deltaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_426279_1 1304883.KI912532_gene2887 2.62e-124 359.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VHN6@28216|Betaproteobacteria,2KW8C@206389|Rhodocyclales 206389|Rhodocyclales L PFAM IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_687901_1 1168034.FH5T_14035 3.23e-140 409.0 COG0364@1|root,COG0364@2|Bacteria,4NE59@976|Bacteroidetes,2FNER@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_295598_1 1144310.PMI07_003165 6.88e-26 105.0 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2U60K@28211|Alphaproteobacteria,4BM6S@82115|Rhizobiaceae 28211|Alphaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_851417_1 929558.SMGD1_0445 1.35e-91 284.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2YN7F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_557250_1 1121468.AUBR01000002_gene639 5.44e-46 166.0 COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia 186801|Clostridia Q gamma-aminobutyrate metabolism dehydratase isomerase - - 1.14.14.9,4.2.1.120,5.3.3.3 ko:K00483,ko:K14534 ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220 M00374,M00375 R02698,R03031,R03299,R10782 RC00046,RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_132175_1 1168034.FH5T_07435 3.1e-112 338.0 COG0369@1|root,COG1151@2|Bacteria,4NGRB@976|Bacteroidetes,2FMDK@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k59_785872_1 95619.PM1_0209115 2.31e-74 242.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleQ - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FleQ,HTH_8,Sigma54_activat k59_262688_2 720554.Clocl_0784 8.37e-32 124.0 COG0145@1|root,COG0145@2|Bacteria,1V3GN@1239|Firmicutes,25DNJ@186801|Clostridia,3WPEF@541000|Ruminococcaceae 186801|Clostridia EQ Protein of unknown function (DUF1638) - - - - - - - - - - - - DUF1638 k59_491727_1 1121104.AQXH01000001_gene1673 1.59e-09 65.1 COG1404@1|root,COG2373@1|root,COG2374@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG3391@1|root,COG4932@1|root,COG5492@1|root,COG1404@2|Bacteria,COG2373@2|Bacteria,COG2374@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,COG5492@2|Bacteria,4P2UU@976|Bacteroidetes,1IXKE@117747|Sphingobacteriia 976|Bacteroidetes MNOQ Cadherin domain - - - - - - - - - - - - CHU_C,Cadherin,DUF285,TIG,TSP_3 k59_66648_1 1219084.AP014508_gene555 1.49e-14 78.2 COG1404@1|root,COG1404@2|Bacteria,2GCI9@200918|Thermotogae 200918|Thermotogae O Belongs to the peptidase S8 family - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_230318_1 1173264.KI913949_gene1024 3.98e-25 109.0 COG0642@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG2964@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,COG2964@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H71H@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_230318_2 483216.BACEGG_03297 1.8e-11 65.5 COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia,4APSW@815|Bacteroidaceae 976|Bacteroidetes T Y_Y_Y domain - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_34020_1 28229.ND2E_1281 1.22e-50 178.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,2Q7JF@267889|Colwelliaceae 1236|Gammaproteobacteria C Ethylbenzene dehydrogenase - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT,EB_dh k59_491728_2 1165841.SULAR_10399 1.06e-18 78.2 COG0690@1|root,COG0690@2|Bacteria,1N8YN@1224|Proteobacteria,42VP0@68525|delta/epsilon subdivisions,2YQ7E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_491728_3 387093.SUN_0126 1.47e-87 259.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2YMJK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_720638_1 484770.UFO1_3156 2.66e-16 77.0 COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,4H51I@909932|Negativicutes 909932|Negativicutes K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_720638_2 469616.FMAG_00186 2.48e-17 79.0 COG0149@1|root,COG0149@2|Bacteria,378PF@32066|Fusobacteria 32066|Fusobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_328434_1 870187.Thini_1183 9.98e-126 369.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,4604Y@72273|Thiotrichales 72273|Thiotrichales G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_1014734_1 1249627.D779_3159 7.86e-85 277.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_426294_1 396588.Tgr7_3057 2.12e-121 366.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_132188_1 998674.ATTE01000001_gene4269 2.65e-52 169.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,460GQ@72273|Thiotrichales 72273|Thiotrichales K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_132188_2 1033802.SSPSH_003117 3.46e-28 105.0 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_262695_2 360107.CHAB381_1565 1.29e-14 73.9 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_949427_1 1249480.B649_06935 2.77e-120 360.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_883977_1 380358.XALC_2647 1.42e-153 442.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,1RPST@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family rci - - - - - - - - - - - Phage_integrase k59_883977_2 697282.Mettu_2751 6.37e-129 371.0 COG0784@1|root,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver - - - - - - - - - - - - EAL,GGDEF,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,Response_reg,Robl_LC7 k59_883977_4 243090.RB9427 2.5e-07 62.4 COG2304@1|root,COG2304@2|Bacteria,2J3A9@203682|Planctomycetes 203682|Planctomycetes S von Willebrand factor type A domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_883977_8 377629.TERTU_0538 0.0 1102.0 COG4928@1|root,COG4928@2|Bacteria,1PJ9W@1224|Proteobacteria,1S0GQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S p-loop domain protein - - - - - - - - - - - - KAP_NTPase k59_883977_9 1419583.V466_23080 7.6e-27 108.0 2ECAY@1|root,3369A@2|Bacteria,1NP2Z@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF4238) - - - - - - - - - - - - DUF4238 k59_883977_10 572547.Amico_0933 6.54e-31 119.0 2ECAY@1|root,3369A@2|Bacteria 2|Bacteria S Protein of unknown function (DUF4238) - - - - - - - - - - - - DUF4238 k59_687924_2 1216976.AX27061_5199 8.35e-05 52.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2VNVX@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_818623_2 360104.CCC13826_0817 2.13e-51 173.0 COG1403@1|root,COG1403@2|Bacteria,1PDCA@1224|Proteobacteria,42WYU@68525|delta/epsilon subdivisions,2YQXR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V HNH endonuclease - - - - - - - - - - - - - k59_818623_3 697282.Mettu_1722 5.38e-36 124.0 COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,1SESI@1236|Gammaproteobacteria,1XGQR@135618|Methylococcales 135618|Methylococcales S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - - - - - - - - - - BrnT_toxin k59_720647_1 1049564.TevJSym_ap00570 3.92e-107 321.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1J4GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_328443_1 1121939.L861_16315 6.4e-56 182.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1XIZA@135619|Oceanospirillales 135619|Oceanospirillales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_328443_2 765911.Thivi_1123 7.56e-62 199.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1WWTH@135613|Chromatiales 135613|Chromatiales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_818626_1 1280689.AUJC01000002_gene823 9.83e-17 78.2 COG5652@1|root,COG5652@2|Bacteria,1VF6Q@1239|Firmicutes,24QQ8@186801|Clostridia,36N1D@31979|Clostridiaceae 186801|Clostridia S PFAM VanZ family protein - - - - - - - - - - - - VanZ k59_426302_2 305900.GV64_10445 5.55e-49 165.0 COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,1SZ3G@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_426306_1 269799.Gmet_3504 8.78e-24 105.0 COG1032@1|root,COG1032@2|Bacteria,1Q4NC@1224|Proteobacteria,42PHK@68525|delta/epsilon subdivisions,2WKNW@28221|Deltaproteobacteria,43UEX@69541|Desulfuromonadales 28221|Deltaproteobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM k59_557291_1 522306.CAP2UW1_0195 5.8e-151 441.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VNNI@28216|Betaproteobacteria 28216|Betaproteobacteria L Evidence 2b Function of strongly homologous gene - - - - - - - - - - - - DDE_Tnp_1 k59_34042_1 572544.Ilyop_2869 1.61e-169 481.0 COG3328@1|root,COG3328@2|Bacteria,379H3@32066|Fusobacteria 32066|Fusobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_753236_1 755732.Fluta_0604 9.96e-06 53.9 COG1357@1|root,COG3291@1|root,COG3405@1|root,COG4412@1|root,COG1357@2|Bacteria,COG3291@2|Bacteria,COG3405@2|Bacteria,COG4412@2|Bacteria,4NMVW@976|Bacteroidetes,1I1JQ@117743|Flavobacteriia,2PBI2@246874|Cryomorphaceae 976|Bacteroidetes G Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_917331_1 1121104.AQXH01000004_gene58 6.53e-84 272.0 COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,1IUTX@117747|Sphingobacteriia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_557841_1 622637.KE124774_gene1240 5.47e-47 166.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,36ZMV@31993|Methylocystaceae 28211|Alphaproteobacteria S Patatin-like phospholipase rssA GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_884292_2 1049564.TevJSym_bl00150 2.45e-173 496.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1J4S0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_884292_3 2340.JV46_15120 1.42e-17 75.5 COG3242@1|root,COG3242@2|Bacteria,1N9FC@1224|Proteobacteria,1SEP6@1236|Gammaproteobacteria,1J79M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2065) - - - ko:K09937 - - - - ko00000 - - - DUF2065 k59_884292_4 857087.Metme_2842 6.18e-101 303.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1XDPP@135618|Methylococcales 135618|Methylococcales O HflC and HflK could regulate a protease - - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_884292_5 1049564.TevJSym_bl00180 5.73e-153 443.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1J4H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_884292_6 1198232.CYCME_0908 7.83e-178 509.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,45ZZ7@72273|Thiotrichales 72273|Thiotrichales S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_884292_7 743974.MBO_01480 3.39e-35 125.0 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,3NK0S@468|Moraxellaceae 1236|Gammaproteobacteria J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_884292_8 1049564.TevJSym_bl00210 2.46e-130 380.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1J4T1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_884292_9 1049564.TevJSym_bl00220 1.15e-251 711.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1J50B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_884292_10 323261.Noc_0337 2.26e-140 417.0 COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales 135613|Chromatiales M Cell wall hydrolase autolysin - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_884292_11 768671.ThimaDRAFT_3776 9.45e-51 167.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1WYI3@135613|Chromatiales 135613|Chromatiales S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_884292_12 1249627.D779_0203 8.99e-195 558.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales 135613|Chromatiales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_884292_13 1469245.JFBG01000023_gene1225 1.66e-154 445.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1WWZ4@135613|Chromatiales 135613|Chromatiales C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_819077_1 395019.Bmul_5123 2.66e-69 236.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,1K22A@119060|Burkholderiaceae 28216|Betaproteobacteria EQ 5-oxoprolinase oplaH - 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_459695_1 1165841.SULAR_05313 6.98e-67 219.0 COG4972@1|root,COG4972@2|Bacteria,1QA6M@1224|Proteobacteria,42NDB@68525|delta/epsilon subdivisions,2YMP2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Pilus assembly protein - - - - - - - - - - - - - k59_394186_1 177437.HRM2_07660 5.64e-22 97.8 COG0614@1|root,COG1865@1|root,COG0614@2|Bacteria,COG1865@2|Bacteria,1QYTY@1224|Proteobacteria,42NSI@68525|delta/epsilon subdivisions,2WKZP@28221|Deltaproteobacteria,2MI0Q@213118|Desulfobacterales 28221|Deltaproteobacteria P Adenosylcobinamide amidohydrolase - - - - - - - - - - - - CbiZ,Peripla_BP_2 k59_165540_2 502347.ESCAB7627_1079 4.37e-60 201.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,3XQCY@561|Escherichia 1236|Gammaproteobacteria K RNA polymerase sigma factor RpoS rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_688411_2 396588.Tgr7_0552 5.52e-34 129.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1WWAK@135613|Chromatiales 135613|Chromatiales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_1440_1 1121405.dsmv_2218 8.98e-77 246.0 COG1960@1|root,COG1960@2|Bacteria,1NU73@1224|Proteobacteria,42Z96@68525|delta/epsilon subdivisions,2WTTK@28221|Deltaproteobacteria,2MN2J@213118|Desulfobacterales 28221|Deltaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_232420_2 1121451.DESAM_20196 4.36e-13 69.7 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2M8YG@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_919278_1 1219065.VPR01S_02_00420 6.78e-52 166.0 COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XXA8@135623|Vibrionales 135623|Vibrionales K Belongs to the P(II) protein family VV0993 - - - - - - - - - - - - k59_919278_2 1049564.TevJSym_ai00560 5.92e-06 46.2 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria 1236|Gammaproteobacteria T CBS domain - - - - - - - - - - - - CBS k59_919282_1 392499.Swit_1701 2.86e-48 175.0 COG0477@1|root,COG2814@2|Bacteria,1QZVG@1224|Proteobacteria,2TYEV@28211|Alphaproteobacteria,2KEM5@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_624636_1 1317124.DW2_13145 4.09e-143 427.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,2XKU4@285107|Thioclava 28211|Alphaproteobacteria L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_820744_1 693661.Arcve_1606 5.89e-05 44.7 COG1149@1|root,arCOG04073@2157|Archaea,2XWS4@28890|Euryarchaeota 28890|Euryarchaeota D 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - CbiA,Fer4,Fer4_21 k59_820744_2 1379281.AVAG01000014_gene1437 8.43e-36 133.0 COG1149@1|root,COG1149@2|Bacteria,1NCD9@1224|Proteobacteria,42PHV@68525|delta/epsilon subdivisions,2WKDZ@28221|Deltaproteobacteria,2M8KV@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Cobyrinic acid ac-diamide synthase - - - - - - - - - - - - CbiA,Fer4,Fer4_6 k59_264732_1 391615.ABSJ01000050_gene1170 9.99e-24 102.0 COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,1SASH@1236|Gammaproteobacteria,1JAPT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretion system (T2SS), protein K gspK - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_35857_1 930169.B5T_03771 1.6e-89 268.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1XI4I@135619|Oceanospirillales 135619|Oceanospirillales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_35857_2 983545.Glaag_3396 1.14e-30 110.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,466ID@72275|Alteromonadaceae 1236|Gammaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_690105_1 1121405.dsmv_1364 2.68e-126 367.0 COG0502@1|root,COG0502@2|Bacteria,1R5JK@1224|Proteobacteria,42PVZ@68525|delta/epsilon subdivisions,2WJP2@28221|Deltaproteobacteria,2MJH6@213118|Desulfobacterales 28221|Deltaproteobacteria H Elongator protein 3, MiaB family, Radical SAM - - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_199532_1 1515615.HQ41_05240 7.77e-23 97.1 COG1752@1|root,COG1752@2|Bacteria,4NISG@976|Bacteroidetes 976|Bacteroidetes S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_199532_2 469618.FVAG_01871 5.94e-86 268.0 COG0488@1|root,COG0488@2|Bacteria,378CA@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 9.97 - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_494070_1 519989.ECTPHS_03929 5.93e-99 296.0 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind k59_624643_1 1122919.KB905568_gene2862 3.35e-36 138.0 COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,4HADJ@91061|Bacilli,26R6N@186822|Paenibacillaceae 91061|Bacilli L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0050896 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_657847_1 1307759.JOMJ01000003_gene927 8.26e-135 407.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,42SZ0@68525|delta/epsilon subdivisions,2WPIR@28221|Deltaproteobacteria,2MAQX@213115|Desulfovibrionales 28221|Deltaproteobacteria L DEAD-like helicase - - - - - - - - - - - - Helicase_C,SNF2_N k59_624644_1 1442598.JABW01000008_gene730 2.34e-54 185.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2YMB1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iIT341.HP1532 GATase_6,SIS k59_624644_2 1123326.JFBL01000004_gene2171 1.59e-26 104.0 COG1752@1|root,COG1752@2|Bacteria,1Q43H@1224|Proteobacteria,42Y72@68525|delta/epsilon subdivisions,2YR75@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_526879_1 526222.Desal_2896 3.01e-123 360.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria,2MGBC@213115|Desulfovibrionales 28221|Deltaproteobacteria C Zinc-binding dehydrogenase tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_984077_1 1333856.L686_18705 1.68e-31 115.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S5JT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_984077_2 640081.Dsui_1254 2.18e-38 143.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2VIV2@28216|Betaproteobacteria,2KVND@206389|Rhodocyclales 206389|Rhodocyclales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_395905_1 558169.AGAV01000008_gene705 2.23e-46 164.0 COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,4HAEU@91061|Bacilli 91061|Bacilli F uracil Permease pyrP - - ko:K02824 - - - - ko00000,ko02000 2.A.40.1.1,2.A.40.1.2 - - Xan_ur_permease k59_134636_1 641526.ADIWIN_0348 2.28e-87 263.0 COG0224@1|root,COG0224@2|Bacteria,4NECM@976|Bacteroidetes,1HX6V@117743|Flavobacteriia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_984080_1 322710.Avin_47720 3.73e-25 105.0 COG3159@1|root,COG3159@2|Bacteria,1RD7B@1224|Proteobacteria,1S539@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09921 - - - - ko00000 - - - DUF484 k59_68868_1 187272.Mlg_0719 3.94e-31 115.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1WX5I@135613|Chromatiales 135613|Chromatiales J Belongs to the SUA5 family - - - - - - - - - - - - Sua5_yciO_yrdC k59_68868_2 626887.J057_20620 1.17e-204 575.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,464FH@72275|Alteromonadaceae 1236|Gammaproteobacteria J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_1016852_1 1121405.dsmv_0302 4.65e-51 177.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2MHTM@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_297604_1 387093.SUN_0172 4.48e-88 270.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2YN1J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase - - - - - - - - - - - - Aminotran_5 k59_35879_1 5786.XP_003292473.1 5.28e-42 150.0 2CY5X@1|root,2S297@2759|Eukaryota,3XDN4@554915|Amoebozoa 554915|Amoebozoa I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_690131_1 870187.Thini_0877 1.29e-26 111.0 COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,1SKBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_885772_1 572544.Ilyop_0425 5.4e-121 365.0 COG0322@1|root,COG0322@2|Bacteria,378EP@32066|Fusobacteria 32066|Fusobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_885772_2 411468.CLOSCI_02541 5.01e-16 77.0 COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,21YWJ@1506553|Lachnoclostridium 186801|Clostridia S Displays ATPase and GTPase activities yvcJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_820771_1 457398.HMPREF0326_00601 1.81e-16 80.5 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2WMCA@28221|Deltaproteobacteria,2MBVF@213115|Desulfovibrionales 28221|Deltaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_428235_1 1382356.JQMP01000003_gene2229 9.97e-38 148.0 COG1306@1|root,COG1306@2|Bacteria,2G81Y@200795|Chloroflexi,27XJ9@189775|Thermomicrobia 189775|Thermomicrobia S Putative glycosyl hydrolase domain - - - - - - - - - - - - CarboxypepD_reg,DUF4015 k59_788032_1 713586.KB900536_gene182 5.92e-07 54.3 COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SGPC@1236|Gammaproteobacteria,1WYNC@135613|Chromatiales 135613|Chromatiales T PFAM Anti sigma-E protein RseA - - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N k59_788032_2 34506.g6061 1.17e-59 206.0 2CZ9K@1|root,2S97H@2759|Eukaryota,399WY@33154|Opisthokonta,3CE13@33208|Metazoa,3DDDG@33213|Bilateria 33208|Metazoa S ECF sigma factor - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_68875_1 1537917.JU82_06935 8.29e-85 270.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2YMF5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent CLP protease ATP-binding subunit clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_199554_1 1537917.JU82_06135 2.76e-48 164.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2YNAC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_199554_2 709032.Sulku_1573 2.6e-116 342.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2YN0I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS k59_494100_2 1123326.JFBL01000011_gene147 8.78e-122 374.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,42MP9@68525|delta/epsilon subdivisions,2YMN8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Type I secretion system ATPase - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran k59_723183_1 574087.Acear_1398 1.46e-39 156.0 COG2887@1|root,COG2887@2|Bacteria,1V0EQ@1239|Firmicutes,24FHF@186801|Clostridia,3WACE@53433|Halanaerobiales 186801|Clostridia L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_723183_2 574087.Acear_1397 9.99e-215 641.0 COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,24AJV@186801|Clostridia,3WAA9@53433|Halanaerobiales 186801|Clostridia L Belongs to the helicase family. UvrD subfamily - - - - - - - - - - - - UvrD-helicase,UvrD_C k59_233043_1 1168034.FH5T_04420 1.63e-39 137.0 COG0024@1|root,COG0024@2|Bacteria,4NIMB@976|Bacteroidetes,2FM2H@200643|Bacteroidia 976|Bacteroidetes E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_854076_1 879212.DespoDRAFT_00500 6.5e-98 286.0 COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,42RSQ@68525|delta/epsilon subdivisions,2WNED@28221|Deltaproteobacteria,2MJRX@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM HPP family - - - ko:K07168 - - - - ko00000 - - - HPP k59_331366_1 1410632.JHWW01000001_gene961 3.01e-93 288.0 COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,27JMA@186928|unclassified Lachnospiraceae 186801|Clostridia G pfkB family carbohydrate kinase - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_168103_1 215803.DB30_3094 1.31e-14 73.9 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria,2YXB7@29|Myxococcales 28221|Deltaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_168103_2 448385.sce4900 7.46e-51 170.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2YU5V@29|Myxococcales 28221|Deltaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_854081_1 583355.Caka_2641 3.75e-27 114.0 2C6BE@1|root,32XBJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_233052_1 1167006.UWK_01429 6.41e-21 97.1 COG2199@1|root,COG3221@1|root,COG3437@1|root,COG4191@1|root,COG2199@2|Bacteria,COG3221@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1MUB8@1224|Proteobacteria,43C4U@68525|delta/epsilon subdivisions,2WMNA@28221|Deltaproteobacteria,2MPN7@213118|Desulfobacterales 28221|Deltaproteobacteria KT HD domain - - - - - - - - - - - - GAF_2,GGDEF,HD k59_919863_1 765912.Thimo_0735 1.49e-106 315.0 COG1443@1|root,COG1443@2|Bacteria,1QXSY@1224|Proteobacteria,1RPX8@1236|Gammaproteobacteria,1WWCS@135613|Chromatiales 135613|Chromatiales I pfam nudix - - - - - - - - - - - - DUF4743,NUDIX k59_919863_2 639283.Snov_2824 2.55e-07 52.4 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,3EXWQ@335928|Xanthobacteraceae 28211|Alphaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_363722_2 310453.XP_007581669.1 1.07e-15 77.8 COG1132@1|root,KOG0254@1|root,KOG0055@2759|Eukaryota,KOG0254@2759|Eukaryota,3AEYK@33154|Opisthokonta,3PBCI@4751|Fungi,3R1TE@4890|Ascomycota,208QI@147541|Dothideomycetes 4751|Fungi Q ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_952119_1 1408473.JHXO01000008_gene2786 3.68e-77 252.0 COG5107@1|root,COG5107@2|Bacteria,4NEPG@976|Bacteroidetes,2FNHC@200643|Bacteroidia 976|Bacteroidetes A Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF349 k59_36441_1 1151061.CAJY01000007_gene2895 5.43e-62 205.0 COG1115@1|root,COG1115@2|Bacteria,2GIU2@201174|Actinobacteria 201174|Actinobacteria E amino acid carrier protein agcS_1 - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_2830_1 439235.Dalk_0125 1.77e-95 303.0 COG2006@1|root,COG2006@2|Bacteria 2|Bacteria U 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - CBM9_1,CBM9_2,DUF362 k59_2830_2 232721.Ajs_2686 4.31e-18 81.6 2C6BU@1|root,32S87@2|Bacteria,1NIFE@1224|Proteobacteria,2VRGB@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_886236_1 1304885.AUEY01000010_gene1646 8.22e-34 129.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MHKJ@213118|Desulfobacterales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_135294_1 592029.DDD_1980 8.21e-10 65.5 COG0768@1|root,COG0768@2|Bacteria,4NE47@976|Bacteroidetes,1HX5G@117743|Flavobacteriia,3HJ5B@363408|Nonlabens 976|Bacteroidetes M Penicillin binding protein transpeptidase domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_168113_1 631362.Thi970DRAFT_01554 3.19e-43 146.0 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,1WY9G@135613|Chromatiales 135613|Chromatiales MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_527542_1 1907.SGLAU_27585 3.66e-21 97.4 COG5297@1|root,COG5297@2|Bacteria,2GK92@201174|Actinobacteria 201174|Actinobacteria G Belongs to the glycosyl hydrolase family 6 guxA2 - 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CBM_2,Glyco_hydro_6 k59_886238_1 1449076.JOOE01000003_gene3798 8.82e-31 122.0 COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2TUVD@28211|Alphaproteobacteria,2K1AR@204457|Sphingomonadales 204457|Sphingomonadales S Methanol dehydrogenase - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase k59_69414_1 265072.Mfla_0757 2.4e-25 111.0 COG1718@1|root,COG1718@2|Bacteria,1QY37@1224|Proteobacteria,2VKUD@28216|Betaproteobacteria,2KKE5@206350|Nitrosomonadales 206350|Nitrosomonadales DT Lipopolysaccharide kinase (Kdo/WaaP) family - - - - - - - - - - - - Kdo k59_854091_1 713587.THITH_10360 2.65e-137 400.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_527546_1 870187.Thini_1164 8.89e-49 169.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_168119_2 870187.Thini_1792 9.34e-17 79.7 COG0842@1|root,COG0842@2|Bacteria,1QTBE@1224|Proteobacteria,1RNG9@1236|Gammaproteobacteria,461U3@72273|Thiotrichales 72273|Thiotrichales V ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane k59_462320_1 1249480.B649_06625 1.95e-126 370.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42NSY@68525|delta/epsilon subdivisions,2YNJN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP - - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_625206_2 68170.KL590523_gene3390 2.68e-38 141.0 COG1156@1|root,COG1156@2|Bacteria,2GKPJ@201174|Actinobacteria,4E26N@85010|Pseudonocardiales 201174|Actinobacteria C ATP synthase alpha/beta family, nucleotide-binding domain - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_690611_1 635013.TherJR_2765 1.18e-68 218.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae 186801|Clostridia G PFAM Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_690611_2 930945.SiRe_1696 7.28e-19 84.7 COG3958@1|root,arCOG01051@2157|Archaea,2XPN2@28889|Crenarchaeota 28889|Crenarchaeota G Transketolase - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_396502_2 1200792.AKYF01000004_gene6030 8.19e-14 72.8 COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,4HCY5@91061|Bacilli,26WEY@186822|Paenibacillaceae 91061|Bacilli M Belongs to the mandelate racemase muconate lactonizing enzyme family ykfB - 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N k59_984647_1 519989.ECTPHS_07331 3.48e-139 424.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_233065_1 1142394.PSMK_09590 2.02e-71 238.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2IX63@203682|Planctomycetes 203682|Planctomycetes G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_462324_1 523794.Lebu_0103 4.93e-55 184.0 COG4804@1|root,COG4804@2|Bacteria,37A5C@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF1016) - - - - - - - - - - - - DUF1016 k59_428730_2 522306.CAP2UW1_1016 1.09e-62 204.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria 1224|Proteobacteria S Hemolysins and related proteins containing CBS domains - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1017446_1 765910.MARPU_12265 1.06e-50 172.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1WX4Z@135613|Chromatiales 135613|Chromatiales S AI-2E family transporter - - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_1017446_2 1158150.KB906243_gene1738 9.81e-20 84.0 2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria,1WYYH@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_886248_1 572544.Ilyop_0115 6e-82 253.0 COG3641@1|root,COG3641@2|Bacteria,378GD@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - ko:K07035 - - - - ko00000 - - - PTS_EIIC_2 k59_821411_1 357804.Ping_0832 5.12e-53 168.0 2DPTG@1|root,333AT@2|Bacteria,1N98Q@1224|Proteobacteria,1SDF5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 k59_821411_2 357804.Ping_0831 3.05e-24 93.6 2CEIZ@1|root,33JKV@2|Bacteria,1NMVX@1224|Proteobacteria,1SIZS@1236|Gammaproteobacteria,2QIE8@267894|Psychromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - KfrA_N k59_919885_1 83406.HDN1F_29180 3.82e-108 323.0 COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,1RR21@1236|Gammaproteobacteria,1J8T5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase yihG - - - - - - - - - - - Acyltransferase k59_463699_1 926556.Echvi_1285 3.96e-46 157.0 COG3958@1|root,COG3958@2|Bacteria,4NEI8@976|Bacteroidetes,47TCG@768503|Cytophagia 976|Bacteroidetes G Transketolase, pyrimidine binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_463699_2 1408473.JHXO01000013_gene506 5.67e-76 235.0 COG3959@1|root,COG3959@2|Bacteria,4NDWK@976|Bacteroidetes,2FR9B@200643|Bacteroidia 976|Bacteroidetes G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_3490_1 1121918.ARWE01000001_gene2086 2.05e-16 75.5 COG1342@1|root,COG1342@2|Bacteria 2|Bacteria S Protein of unknown function DUF134 - - - - - - - - - - - - DUF134,Nitro_FeMo-Co k59_3490_2 572479.Hprae_1446 2.67e-67 219.0 COG1149@1|root,COG1149@2|Bacteria,1TQI9@1239|Firmicutes,2484J@186801|Clostridia,3WAGC@53433|Halanaerobiales 186801|Clostridia C CobQ CobB MinD ParA nucleotide binding domain - - - - - - - - - - - - CbiA,Fer4 k59_3490_3 1408439.JHXW01000011_gene181 2.46e-60 200.0 COG1149@1|root,COG1149@2|Bacteria,37895@32066|Fusobacteria 32066|Fusobacteria C NUBPL iron-transfer P-loop NTPase - - - - - - - - - - - - CbiA,Fer4 k59_3490_4 177437.HRM2_15510 1.85e-14 72.8 COG1433@1|root,COG1433@2|Bacteria,1RHT9@1224|Proteobacteria,42T9R@68525|delta/epsilon subdivisions,2WPV5@28221|Deltaproteobacteria,2MK8D@213118|Desulfobacterales 28221|Deltaproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_3490_5 1379281.AVAG01000014_gene1439 0.000129 44.3 2DNMM@1|root,32Y53@2|Bacteria,1NBV1@1224|Proteobacteria,42VC7@68525|delta/epsilon subdivisions,2WSE6@28221|Deltaproteobacteria,2ME5Q@213115|Desulfovibrionales 28221|Deltaproteobacteria S Family of unknown function (DUF5320) - - - - - - - - - - - - DUF5320 k59_3490_6 1541959.KQ51_01297 2.24e-39 138.0 COG1342@1|root,COG1433@1|root,COG1342@2|Bacteria,COG1433@2|Bacteria 2|Bacteria S nitrogen fixation - - - - - - - - - - - - DUF134,Nitro_FeMo-Co,ParA k59_3490_7 1396141.BATP01000061_gene4534 2.03e-25 104.0 2C854@1|root,30DR2@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DinB_2 k59_3490_8 1304275.C41B8_12634 5.78e-15 72.4 2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_3490_9 765912.Thimo_0194 1.34e-182 521.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales 135613|Chromatiales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_3490_10 1049564.TevJSym_al00510 4.97e-105 309.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1J53N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner lolD GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778 - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_3490_11 1179778.PMM47T1_26902 1.78e-62 197.0 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria TLL0138 - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_3490_12 631362.Thi970DRAFT_04820 1.01e-197 589.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1WWQ3@135613|Chromatiales 135613|Chromatiales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_3490_13 396588.Tgr7_1369 1.09e-88 266.0 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_3490_14 545276.KB898726_gene943 2.29e-29 111.0 COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,1WYEK@135613|Chromatiales 135613|Chromatiales U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_3490_15 1049564.TevJSym_al00460 1.57e-118 352.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1J5MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396 LpxK k59_3490_16 493475.GARC_1237 1.79e-19 80.5 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,1SCFF@1236|Gammaproteobacteria,468JV@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0434 family ycaR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09791 - - - - ko00000 - - - Trm112p k59_3490_17 1049564.TevJSym_al00440 3.74e-110 324.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1J5FQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008690,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0046401,GO:0046872,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF1260.b0918,iB21_1397.B21_00929,iBWG_1329.BWG_0770,iECBD_1354.ECBD_2677,iECB_1328.ECB_00922,iECDH10B_1368.ECDH10B_0988,iECDH1ME8569_1439.ECDH1ME8569_0869,iECD_1391.ECD_00922,iETEC_1333.ETEC_0986,iEcDH1_1363.EcDH1_2725,iEcHS_1320.EcHS_A1025,iEcolC_1368.EcolC_2678,iJO1366.b0918,iJR904.b0918,iPC815.YPO1400,iUMNK88_1353.UMNK88_1071,iY75_1357.Y75_RS04770 CTP_transf_3 k59_3490_18 388739.RSK20926_05992 1.45e-47 155.0 COG3422@1|root,COG3422@2|Bacteria,1N0S6@1224|Proteobacteria,2VGBP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF1508) - - - - - - - - - - - - DUF1508 k59_3490_19 2340.JV46_06120 1.6e-131 382.0 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,1J5MC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative neutral zinc metallopeptidase ypfJ - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_3490_20 595494.Tola_0685 2.61e-57 187.0 2EDDS@1|root,337A2@2|Bacteria,1NAD0@1224|Proteobacteria,1SDWE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_3490_23 42254.XP_004619765.1 0.000818 48.5 KOG1584@1|root,KOG1584@2759|Eukaryota,38ECR@33154|Opisthokonta,3BMW6@33208|Metazoa,3CYVD@33213|Bilateria,4890N@7711|Chordata,497DC@7742|Vertebrata,3J2FU@40674|Mammalia 33208|Metazoa S bile-salt sulfotransferase activity SULT2A1 - 2.8.2.14,2.8.2.2 ko:K01015,ko:K11822 ko00140,ko00980,ko04976,ko05204,map00140,map00980,map04976,map05204 - R00629,R03405,R08977,R08978,R09444 RC00007,RC00134,RC00231,RC00341 ko00000,ko00001,ko01000 - - - Sulfotransfer_1 k59_3490_24 768710.DesyoDRAFT_5380 5.45e-45 172.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,260S8@186807|Peptococcaceae 186801|Clostridia C PFAM Radical SAM scfB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_3490_25 868131.MSWAN_0524 2.63e-34 141.0 COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,23PFJ@183925|Methanobacteria 183925|Methanobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM k59_3490_26 765913.ThidrDRAFT_0973 2.37e-66 206.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,1WY50@135613|Chromatiales 135613|Chromatiales T low molecular weight - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_3490_27 1049564.TevJSym_al00380 2.47e-282 816.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1J4XZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_3490_29 1049564.TevJSym_al00370 1.9e-128 376.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1J54Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_3490_30 768671.ThimaDRAFT_2882 5.5e-79 243.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1WVZ9@135613|Chromatiales 135613|Chromatiales S subfamily IA, variant 1 - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_3490_31 105559.Nwat_0243 2.82e-119 353.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1WWM5@135613|Chromatiales 135613|Chromatiales OU PFAM peptidase S49 - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_529468_1 313596.RB2501_08635 4.74e-22 95.1 COG0554@1|root,COG0554@2|Bacteria,4NFUH@976|Bacteroidetes,1HX3Z@117743|Flavobacteriia 976|Bacteroidetes H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_529468_2 1500890.JQNL01000001_gene2746 1.34e-50 169.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1X4AQ@135614|Xanthomonadales 135614|Xanthomonadales M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_953620_1 566466.NOR53_3227 1.75e-46 164.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1J804@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_398049_1 1278073.MYSTI_05326 9.26e-45 172.0 COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1Q52Y@1224|Proteobacteria,43A3Z@68525|delta/epsilon subdivisions,2XA2T@28221|Deltaproteobacteria,2YTU6@29|Myxococcales 28221|Deltaproteobacteria Q PKS_KR - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_757129_1 572544.Ilyop_0729 1.11e-254 726.0 COG0744@1|root,COG0744@2|Bacteria,379FN@32066|Fusobacteria 32066|Fusobacteria M penicillin-binding protein 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_757129_2 572544.Ilyop_0797 4.94e-82 246.0 COG4807@1|root,COG4807@2|Bacteria,379XJ@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF1456) - - - - - - - - - - - - DUF1456 k59_757129_3 545693.BMQ_0790 4.04e-28 102.0 COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,4HNJA@91061|Bacilli,1ZIX5@1386|Bacillus 91061|Bacilli S Uncharacterized conserved protein (DUF2196) ywbE - - - - - - - - - - - DUF2196 k59_104408_1 754436.JCM19237_6976 7.98e-10 60.8 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1XVQC@135623|Vibrionales 135623|Vibrionales C COG2863 Cytochrome c553 cc4 - - - - - - - - - - - Cytochrom_C k59_71271_1 1262914.BN533_01859 1.9e-77 248.0 COG4670@1|root,COG4670@2|Bacteria,1TQ4Z@1239|Firmicutes 1239|Firmicutes I Malonate decarboxylase, alpha subunit, transporter mdcA - 2.3.1.187 ko:K13929 - - R08944 RC00012,RC00014 ko00000,ko01000,ko02000 3.B.1.1.4 - - Mal_decarbox_Al k59_823241_1 1165841.SULAR_00120 2.47e-108 342.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2YMA1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_626964_1 69328.PVLB_12680 4.88e-103 318.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_365663_1 653733.Selin_1606 0.000413 44.3 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity btuB GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696 Plug,TonB_dep_Rec k59_365663_2 1219375.CM002139_gene1251 3.75e-44 148.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales 135614|Xanthomonadales S adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_692366_1 1165841.SULAR_10139 4.43e-95 291.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2YN8R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_3805_1 1355374.JARU01000001_gene354 1.18e-56 182.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,43ADI@68525|delta/epsilon subdivisions,2YT1T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_3805_2 944547.ABLL_0738 1.57e-27 110.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2YMWB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Biotin carboxylase pycA - 6.3.4.14,6.4.1.1,6.4.1.2 ko:K01959,ko:K01961 ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00376,M00620 R00344,R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_660175_1 1131462.DCF50_p1707 1.17e-43 157.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,263T5@186807|Peptococcaceae 186801|Clostridia L Reverse transcriptase (RNA-dependent DNA polymerase) ltrA1 - - - - - - - - - - - GIIM,RVT_1 k59_299596_1 525146.Ddes_1282 1.09e-09 58.5 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2M8VR@213115|Desulfovibrionales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_299596_2 96561.Dole_0012 1.14e-17 86.7 COG5616@1|root,COG5616@2|Bacteria,1RBBE@1224|Proteobacteria,42QR8@68525|delta/epsilon subdivisions,2WN1X@28221|Deltaproteobacteria,2MHSI@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Curli production assembly transport component CsgG - - - - - - - - - - - - CsgG,VCBS k59_724830_1 572544.Ilyop_1329 0.0 950.0 COG2176@1|root,COG2176@2|Bacteria,378MN@32066|Fusobacteria 32066|Fusobacteria L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T k59_496462_1 1131553.JIBI01000050_gene1003 5.41e-137 409.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria 28216|Betaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG2 - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1019281_1 572544.Ilyop_0551 1.29e-171 491.0 COG1301@1|root,COG1301@2|Bacteria,37BSI@32066|Fusobacteria 32066|Fusobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_1019281_2 1408439.JHXW01000003_gene1517 1.29e-20 83.2 COG4224@1|root,COG4224@2|Bacteria,37AXK@32066|Fusobacteria 32066|Fusobacteria S Bacterial protein of unknown function (DUF896) - - - - - - - - - - - - DUF896 k59_1019281_3 556263.FSEG_01802 9.22e-263 728.0 COG0017@1|root,COG0017@2|Bacteria,379C5@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1019281_4 1411685.U062_02080 2.28e-45 157.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,1J5VX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family yiaD - - ko:K12216 - - - - ko00000,ko02044 3.A.7.9.1 - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA k59_1019281_5 1304888.ATWF01000001_gene2365 3.86e-71 221.0 COG1584@1|root,COG1584@2|Bacteria,2GEZ8@200930|Deferribacteres 200930|Deferribacteres S GPR1/FUN34/yaaH family - - - ko:K07034 - - - - ko00000 - - - Grp1_Fun34_YaaH k59_1019281_6 469616.FMAG_01204 1.43e-88 266.0 COG0652@1|root,COG0652@2|Bacteria,379Y4@32066|Fusobacteria 32066|Fusobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides cypB - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_1019281_7 469618.FVAG_02187 6.25e-33 125.0 28MHF@1|root,2ZAUC@2|Bacteria,378M1@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_1019281_8 558169.AGAV01000014_gene1665 9.11e-18 82.8 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,4HA6H@91061|Bacilli 91061|Bacilli E Cysteine desulfurase iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_953628_1 709032.Sulku_0494 1.8e-58 190.0 COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42N4V@68525|delta/epsilon subdivisions,2YN04@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RluA family rluA - 5.4.99.23,5.4.99.24 ko:K06179,ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_953628_2 563040.Saut_1762 1.86e-44 155.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2YN62@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M 3-deoxy-d-manno-octulosonic-acid transferase kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 iIT341.HP0957 Glycos_transf_N k59_660177_1 283942.IL1556 2.09e-25 104.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,2QFHW@267893|Idiomarinaceae 1236|Gammaproteobacteria H Amino-transferase class IV ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_660177_2 1123256.KB907928_gene1973 4.49e-20 88.6 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RMJR@1236|Gammaproteobacteria,1X3BI@135614|Xanthomonadales 135614|Xanthomonadales C e3 binding domain - - - - - - - - - - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_593865_1 572544.Ilyop_0153 3.6e-108 316.0 COG1180@1|root,COG1180@2|Bacteria,378RY@32066|Fusobacteria 32066|Fusobacteria C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_855874_1 37659.JNLN01000001_gene1528 2.05e-26 111.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae 186801|Clostridia C NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - ADC,Oxidored_FMN,Pyr_redox_2 k59_137314_1 1247963.JPHU01000009_gene2281 5.33e-32 120.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria 1224|Proteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_398061_1 96561.Dole_2840 8.93e-06 47.4 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,2MI18@213118|Desulfobacterales 28221|Deltaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_398061_2 1415780.JPOG01000001_gene1166 7.77e-54 174.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1X6GB@135614|Xanthomonadales 135614|Xanthomonadales I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_887755_1 177437.HRM2_05930 4.17e-31 112.0 COG0426@1|root,COG0426@2|Bacteria,1N47N@1224|Proteobacteria,42UNB@68525|delta/epsilon subdivisions,2WQA6@28221|Deltaproteobacteria,2MQ13@213118|Desulfobacterales 28221|Deltaproteobacteria C domain, Protein - - - - - - - - - - - - Flavodoxin_5 k59_887755_2 555779.Dthio_PD3255 1.67e-20 84.3 2ED51@1|root,3371S@2|Bacteria,1P2UH@1224|Proteobacteria,43180@68525|delta/epsilon subdivisions,2WWP0@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_660180_1 1165841.SULAR_08457 2.88e-77 243.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,42P1T@68525|delta/epsilon subdivisions,2YMMQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_496475_1 1168034.FH5T_09210 1.25e-20 90.1 COG4948@1|root,COG4948@2|Bacteria,4PKP3@976|Bacteroidetes,2FMI4@200643|Bacteroidia 976|Bacteroidetes M COG NOG06228 non supervised orthologous group - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - GH97_C,GH97_N,Glyco_hydro_97 k59_496475_2 1168034.FH5T_09205 5.31e-67 227.0 COG1629@1|root,COG4206@1|root,COG4219@1|root,COG4206@2|Bacteria,COG4219@2|Bacteria,COG4771@2|Bacteria,4NDWS@976|Bacteroidetes,2FNCU@200643|Bacteroidia 976|Bacteroidetes KT Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - Peptidase_M56,Plug,TonB_C k59_333287_3 666684.AfiDRAFT_0962 0.000451 43.9 COG3585@1|root,COG3585@2|Bacteria,1N7IB@1224|Proteobacteria,2UFW3@28211|Alphaproteobacteria,3K0YE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H TOBE domain mop - - - - - - - - - - - TOBE k59_333287_5 563040.Saut_1953 7.56e-129 374.0 COG3842@1|root,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,42MSG@68525|delta/epsilon subdivisions,2YMX7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E ATP-binding protein modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran k59_333287_6 709032.Sulku_1151 1.5e-35 131.0 COG0614@1|root,COG0614@2|Bacteria,1NVK4@1224|Proteobacteria,42MBT@68525|delta/epsilon subdivisions,2YMTN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_757164_1 338969.Rfer_3108 4.26e-23 100.0 COG1794@1|root,COG1794@2|Bacteria,1QEFX@1224|Proteobacteria,2VM7U@28216|Betaproteobacteria,4ACVP@80864|Comamonadaceae 28216|Betaproteobacteria M aspartate racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_790139_1 279010.BL00628 3.69e-47 163.0 COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HANQ@91061|Bacilli,1ZBUT@1386|Bacillus 91061|Bacilli H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iSB619.SA_RS08395 Aminotran_3 k59_790139_2 1168034.FH5T_12750 1.09e-159 453.0 COG0113@1|root,COG0113@2|Bacteria,4NFW6@976|Bacteroidetes,2FPXC@200643|Bacteroidia 976|Bacteroidetes H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_234763_1 765912.Thimo_3336 2.91e-84 265.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1X2PB@135613|Chromatiales 135613|Chromatiales EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_170033_1 43989.cce_4394 8.52e-11 65.1 COG0457@1|root,COG0457@2|Bacteria,1G7C5@1117|Cyanobacteria,3KIQY@43988|Cyanothece 1117|Cyanobacteria S Putative capsular polysaccharide synthesis protein - - - - - - - - - - - - NKWYS k59_170033_2 525903.Taci_0678 3.1e-204 578.0 COG0001@1|root,COG0001@2|Bacteria,3TAGM@508458|Synergistetes 508458|Synergistetes H PFAM Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_170033_3 909663.KI867150_gene1987 2.94e-33 131.0 COG0667@1|root,COG0667@2|Bacteria,1RC4U@1224|Proteobacteria,42STR@68525|delta/epsilon subdivisions,2WS49@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_170033_4 709797.CSIRO_3855 1.7e-110 337.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria,3JSRK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_170033_5 1123274.KB899438_gene661 2.45e-162 484.0 COG1132@1|root,COG1132@2|Bacteria,2J5VU@203691|Spirochaetes 203691|Spirochaetes V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_membrane,ABC_tran k59_562049_2 1158292.JPOE01000002_gene2291 1.54e-16 77.8 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,1KIZ4@119065|unclassified Burkholderiales 28216|Betaproteobacteria O XdhC Rossmann domain - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_855900_1 1172190.M947_05965 1.03e-88 288.0 COG2887@1|root,COG2887@2|Bacteria,1QUIU@1224|Proteobacteria,42M7I@68525|delta/epsilon subdivisions,2YMX0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG3893 inactivated superfamily I helicase addB - - - - - - - - - - - PDDEXK_1 k59_497903_1 1449126.JQKL01000041_gene986 3.11e-99 305.0 COG1304@1|root,COG1304@2|Bacteria,1TPC5@1239|Firmicutes,247PK@186801|Clostridia,26AHZ@186813|unclassified Clostridiales 186801|Clostridia C Conserved region in glutamate synthase - - - - - - - - - - - - Glu_synthase k59_105859_1 177437.HRM2_38640 2.73e-119 357.0 COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria,2MI0B@213118|Desulfobacterales 28221|Deltaproteobacteria I Carboxyl transferase domain gcdA - 4.1.1.70 ko:K01615 ko00362,ko00650,ko01120,map00362,map00650,map01120 - R03028 RC00832 ko00000,ko00001,ko01000,ko02000 3.B.1.1.3 - - Carboxyl_trans k59_465313_1 1168034.FH5T_09760 3.13e-150 446.0 COG2010@1|root,COG2993@1|root,COG3278@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO k59_889147_1 566466.NOR53_2862 3.32e-13 73.2 2ECN7@1|root,32Y4C@2|Bacteria,1NEKK@1224|Proteobacteria,1SRX6@1236|Gammaproteobacteria,1JB3V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_987869_1 1500259.JQLD01000019_gene4595 9.12e-48 162.0 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria 1224|Proteobacteria U PFAM MotA TolQ ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_824410_1 1129794.C427_2026 1.48e-61 214.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,46415@72275|Alteromonadaceae 1236|Gammaproteobacteria OU COG0616 Periplasmic serine proteases (ClpP class) sppA GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_236012_1 1121405.dsmv_2608 1.07e-71 226.0 COG0498@1|root,COG0498@2|Bacteria 2|Bacteria E threonine synthase activity - - 2.5.1.76,4.2.3.1 ko:K01733,ko:K15527 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,PALP k59_431415_1 387093.SUN_0201 1.94e-64 204.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2YMWJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C pyruvate ferredoxin oxidoreductase porB - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_431417_1 1304883.KI912532_gene2250 1.84e-74 235.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,2VHMT@28216|Betaproteobacteria,2KVPY@206389|Rhodocyclales 206389|Rhodocyclales S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_726020_1 1408322.JHYK01000009_gene2212 1.21e-25 101.0 COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia,27NP9@186928|unclassified Lachnospiraceae 186801|Clostridia S Putative redox-active protein (C_GCAxxG_C_C) - - - - - - - - - - - - C_GCAxxG_C_C k59_693678_1 1410608.JNKX01000034_gene2243 1.82e-48 170.0 COG3401@1|root,COG3401@2|Bacteria,4NIS0@976|Bacteroidetes,2FRBY@200643|Bacteroidia,4AKYV@815|Bacteroidaceae 976|Bacteroidetes S Domain of unknown function - - - - - - - - - - - - Beta_helix,DUF1565,DUF4990 k59_694299_1 1121438.JNJA01000001_gene2119 2.74e-82 266.0 COG0300@1|root,COG1032@1|root,COG0300@2|Bacteria,COG1032@2|Bacteria,1NGXF@1224|Proteobacteria,42Q5Q@68525|delta/epsilon subdivisions,2WNMS@28221|Deltaproteobacteria,2MA3D@213115|Desulfovibrionales 28221|Deltaproteobacteria C Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - Radical_SAM,adh_short k59_629177_1 998674.ATTE01000001_gene4273 3.56e-31 112.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,460RJ@72273|Thiotrichales 72273|Thiotrichales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_629177_2 159087.Daro_0312 7.22e-13 68.2 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KV0Q@206389|Rhodocyclales 206389|Rhodocyclales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_563931_1 1410626.JHXB01000015_gene828 5.51e-90 272.0 COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,27JM6@186928|unclassified Lachnospiraceae 186801|Clostridia T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_498633_1 1211114.ALIP01000111_gene1257 6.62e-85 267.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1X3B2@135614|Xanthomonadales 135614|Xanthomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_236620_1 765911.Thivi_0537 1.32e-106 321.0 COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,1S13M@1236|Gammaproteobacteria,1WWSG@135613|Chromatiales 135613|Chromatiales S PFAM Alpha beta hydrolase of - - - - - - - - - - - - DUF900 k59_563934_1 643562.Daes_0344 7.6e-36 140.0 COG2199@1|root,COG5001@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K21084 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - CHASE,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,SBP_bac_3,dCache_1 k59_1021117_1 709032.Sulku_2491 6.35e-142 427.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,43BQI@68525|delta/epsilon subdivisions,2YRHF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K17050 - - - - ko00000,ko02000 5.A.3.8 - - Molybdopterin,Molydop_binding k59_531427_1 565045.NOR51B_1193 1.7e-92 284.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system, permease component VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_531427_2 395494.Galf_2066 3.35e-126 375.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VIIH@28216|Betaproteobacteria,44V5Z@713636|Nitrosomonadales 28216|Betaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_694308_1 765910.MARPU_01680 4.95e-45 150.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1WYAA@135613|Chromatiales 135613|Chromatiales G PTS IIA-like nitrogen-regulatory protein PtsN - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_759212_1 1387312.BAUS01000002_gene985 6.81e-11 68.2 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,2VNEJ@28216|Betaproteobacteria,2KKQV@206350|Nitrosomonadales 206350|Nitrosomonadales S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 k59_465917_1 1168034.FH5T_08455 1.2e-21 92.8 COG1983@1|root,COG1983@2|Bacteria,4NG3T@976|Bacteroidetes,2FPZX@200643|Bacteroidia 976|Bacteroidetes KT PspC domain protein - - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - DUF2807,PspC k59_465917_2 1168034.FH5T_08450 1.05e-59 185.0 COG1695@1|root,COG1695@2|Bacteria,4NSI4@976|Bacteroidetes,2FTF6@200643|Bacteroidia 976|Bacteroidetes K transcriptional regulator PadR family - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR k59_5045_1 935863.AWZR01000005_gene2148 2.46e-18 85.5 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,1RQUG@1236|Gammaproteobacteria,1X59Q@135614|Xanthomonadales 135614|Xanthomonadales S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_5045_2 485917.Phep_3602 9.58e-12 66.6 COG1704@1|root,COG1704@2|Bacteria,4NMD3@976|Bacteroidetes,1IS2G@117747|Sphingobacteriia 976|Bacteroidetes S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_139298_2 387093.SUN_1243 3.75e-190 543.0 COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria,43CEV@68525|delta/epsilon subdivisions,2YRH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_694314_1 749222.Nitsa_0295 2.4e-85 263.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2YMW7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_367759_1 272633.26454463 5.52e-41 141.0 COG0094@1|root,COG0094@2|Bacteria,3WT4K@544448|Tenericutes 544448|Tenericutes J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_955280_1 1165841.SULAR_03123 7.13e-68 218.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,42RT7@68525|delta/epsilon subdivisions,2YRF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_857508_1 642492.Clole_3329 4.54e-98 299.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia 186801|Clostridia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_531451_1 326298.Suden_1107 3.19e-30 115.0 2AIU4@1|root,319B6@2|Bacteria,1Q28N@1224|Proteobacteria,42V6E@68525|delta/epsilon subdivisions,2YQ6D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_106611_2 207559.Dde_3161 0.000518 43.1 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2M7UC@213115|Desulfovibrionales 28221|Deltaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_367762_1 1168034.FH5T_05860 8.11e-136 394.0 COG5002@1|root,COG5002@2|Bacteria,4NETP@976|Bacteroidetes,2FKYG@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_857514_1 1168034.FH5T_02810 6.43e-121 352.0 2BZ6M@1|root,2Z7HW@2|Bacteria,4NDZE@976|Bacteroidetes,2FWW8@200643|Bacteroidia 976|Bacteroidetes S Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 k59_367767_1 156889.Mmc1_1928 1.39e-26 107.0 COG3221@1|root,COG3221@2|Bacteria 2|Bacteria P organic phosphonate transport - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_531458_1 592027.CLG_B0058 1.82e-71 225.0 COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia,36W7D@31979|Clostridiaceae 186801|Clostridia G Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP) iolC - 2.7.1.4,2.7.1.92 ko:K00847,ko:K03338 ko00051,ko00500,ko00520,ko00562,ko01100,ko01120,map00051,map00500,map00520,map00562,map01100,map01120 - R00760,R00867,R03920,R05661 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_857517_1 1537917.JU82_08465 4.4e-57 191.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2YM8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.5.1 ko:K05922 - - - - ko00000,ko01000 - - - NiFeSe_Hases k59_857517_2 709032.Sulku_2050 4.91e-56 180.0 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,42NQ3@68525|delta/epsilon subdivisions,2YMRF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ni Fe-hydrogenase, b-type cytochrome subunit - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_171663_1 641491.DND132_0932 1.3e-64 220.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2M86M@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM glycosyl transferase family 51 mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_106616_1 886379.AEWI01000007_gene811 2.96e-08 56.2 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,4NDXY@976|Bacteroidetes,2FNEV@200643|Bacteroidia,3XJGX@558415|Marinilabiliaceae 976|Bacteroidetes M Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_106616_2 1120968.AUBX01000010_gene1157 1.42e-59 187.0 COG2764@1|root,COG2764@2|Bacteria,4NQD7@976|Bacteroidetes,47RGC@768503|Cytophagia 976|Bacteroidetes S 3-demethylubiquinone-9 3-methyltransferase - - - ko:K04750 - - - - ko00000 - - - 3-dmu-9_3-mt k59_106616_3 205922.Pfl01_5042 2.12e-20 87.4 COG1335@1|root,COG1335@2|Bacteria,1RDHA@1224|Proteobacteria,1S5NR@1236|Gammaproteobacteria,1YNDC@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_236655_2 926550.CLDAP_37030 1.36e-41 150.0 COG0028@1|root,COG0028@2|Bacteria,2G7NZ@200795|Chloroflexi 200795|Chloroflexi EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_825055_1 1168034.FH5T_04040 1.32e-71 220.0 COG0135@1|root,COG0135@2|Bacteria,4NNQ1@976|Bacteroidetes,2FPJD@200643|Bacteroidia 976|Bacteroidetes E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_825055_2 1168034.FH5T_04045 6.81e-40 141.0 COG0133@1|root,COG0133@2|Bacteria,4NDWP@976|Bacteroidetes,2FP09@200643|Bacteroidia 976|Bacteroidetes E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20,5.3.1.24 ko:K01696,ko:K01817 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722,R03509 RC00209,RC00210,RC00700,RC00701,RC00945,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_106621_1 1270196.JCKI01000004_gene888 1.75e-30 119.0 2A263@1|root,30QGN@2|Bacteria,4NMYV@976|Bacteroidetes,1ISPH@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_563986_1 1499967.BAYZ01000184_gene4579 5.92e-51 170.0 28NH4@1|root,2ZBJ2@2|Bacteria,2NQY1@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_367784_1 1150621.SMUL_1602 6.91e-66 223.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2YMT6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1021167_1 1168034.FH5T_11925 1.78e-09 57.8 COG0849@1|root,COG0849@2|Bacteria,4NE0V@976|Bacteroidetes,2FMUG@200643|Bacteroidia 976|Bacteroidetes D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_1021167_2 1168034.FH5T_11920 2.02e-53 175.0 COG1589@1|root,COG1589@2|Bacteria,4NGPN@976|Bacteroidetes,2FME2@200643|Bacteroidia 976|Bacteroidetes M Psort location Cytoplasmic, score 8.96 ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ k59_531477_1 749222.Nitsa_0602 1.07e-11 59.7 2E3BY@1|root,32YBB@2|Bacteria,1NDZS@1224|Proteobacteria,42X6C@68525|delta/epsilon subdivisions,2YQWP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF4492) - - - - - - - - - - - - DUF4492 k59_531477_2 944547.ABLL_1440 4.56e-86 267.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2YM8D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C oxidase subunit I cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_367789_1 1382306.JNIM01000001_gene1177 4.87e-24 102.0 COG1364@1|root,COG1364@2|Bacteria,2G64K@200795|Chloroflexi 200795|Chloroflexi E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_726665_1 1049564.TevJSym_at00700 3.98e-86 280.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1J4YE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_73555_1 387093.SUN_1063 6.82e-28 109.0 COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2YNB0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P periplasmic solute binding protein znuA - - ko:K02077,ko:K09815 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ZinT,ZnuA k59_857541_2 1304872.JAGC01000003_gene2864 7.9e-61 203.0 COG3866@1|root,COG3866@2|Bacteria,1RFAV@1224|Proteobacteria 1224|Proteobacteria G Parallel beta-helix repeats - - - - - - - - - - - - Beta_helix k59_5080_1 1165841.SULAR_08090 9.73e-86 273.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,42MP9@68525|delta/epsilon subdivisions,2YMN8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Type I secretion system ATPase - - - ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_432118_1 1440052.EAKF1_ch2993 7.22e-18 84.3 COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,3XPFX@561|Escherichia 1236|Gammaproteobacteria U Type II secretion system (T2SS), protein J gspJ GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSJ k59_694361_1 134676.ACPL_5345 2.18e-83 264.0 COG5297@1|root,COG5297@2|Bacteria,2GK92@201174|Actinobacteria,4D9YE@85008|Micromonosporales 201174|Actinobacteria G Belongs to the glycosyl hydrolase family 6 - - 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CBM_2,Glyco_hydro_6 k59_139351_1 1121405.dsmv_1084 2.75e-83 253.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales 28221|Deltaproteobacteria N ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_629260_1 398767.Glov_2122 1.52e-29 116.0 COG3267@1|root,COG3267@2|Bacteria,1REY9@1224|Proteobacteria,42RJB@68525|delta/epsilon subdivisions,2WN99@28221|Deltaproteobacteria,43TEB@69541|Desulfuromonadales 28221|Deltaproteobacteria U Pfam:Arch_ATPase - - - - - - - - - - - - AAA_22 k59_73557_2 765913.ThidrDRAFT_2274 4.63e-50 181.0 COG0515@1|root,COG1262@1|root,COG2909@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG2909@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria,1X2K2@135613|Chromatiales 135613|Chromatiales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - FGE-sulfatase,Pkinase k59_759282_1 1537917.JU82_02320 3.22e-103 322.0 COG1287@1|root,COG1287@2|Bacteria,1R8YG@1224|Proteobacteria,43BIB@68525|delta/epsilon subdivisions,2YT8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Oligosaccharide transferase - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_1021183_1 1165841.SULAR_03432 1.26e-05 47.8 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,42YVP@68525|delta/epsilon subdivisions,2YRC0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Conserved region in glutamate synthase - - - - - - - - - - - - Glu_synthase k59_1021183_2 563040.Saut_2070 1.69e-64 201.0 COG2259@1|root,COG2259@2|Bacteria,1RKEE@1224|Proteobacteria,42SF5@68525|delta/epsilon subdivisions,2YPGK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DoxX family - - - ko:K15977 - - - - ko00000 - - - DoxX k59_204088_1 1123228.AUIH01000038_gene2741 2.03e-16 81.6 2AQZG@1|root,31G87@2|Bacteria,1RJKR@1224|Proteobacteria,1S81D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S FlgD Ig-like domain - - - - - - - - - - - - FlgD_ig k59_39412_1 1196095.GAPWK_1463 2.77e-26 105.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_432130_1 1370122.JHXQ01000023_gene3019 1.16e-55 191.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,4B76T@82115|Rhizobiaceae 28211|Alphaproteobacteria M gamma-glutamyltransferase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_432130_2 1192124.LIG30_3851 2.83e-11 61.2 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1K4S6@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_139362_1 1121403.AUCV01000031_gene2838 1.24e-42 160.0 COG1361@1|root,COG3540@1|root,COG4733@1|root,COG1361@2|Bacteria,COG3540@2|Bacteria,COG4733@2|Bacteria,1QVSF@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,OmpA_membrane k59_694362_2 1304284.L21TH_1794 3.08e-43 150.0 COG2059@1|root,COG2059@2|Bacteria,1V43H@1239|Firmicutes,24JTX@186801|Clostridia,36IGJ@31979|Clostridiaceae 186801|Clostridia P Chromate transport protein - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_184628_1 203120.LEUM_0615 1.89e-06 52.0 COG0584@1|root,COG0584@2|Bacteria,1VB6Y@1239|Firmicutes,4HN40@91061|Bacilli 91061|Bacilli C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_737947_2 497965.Cyan7822_1448 7.99e-32 127.0 COG0392@1|root,COG0392@2|Bacteria,1G3F6@1117|Cyanobacteria,3KFWD@43988|Cyanothece 1117|Cyanobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - DUF2156,LPG_synthase_TM k59_576201_1 869213.JCM21142_93473 1.39e-95 293.0 COG0407@1|root,COG0407@2|Bacteria 2|Bacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - Thioredoxin_3,URO-D k59_217223_1 95619.PM1_0201420 1.52e-54 184.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275 DHQ_synthase k59_217223_2 1123401.JHYQ01000021_gene1030 6.44e-79 246.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,460J2@72273|Thiotrichales 72273|Thiotrichales F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_379846_1 1121405.dsmv_1797 6.21e-47 157.0 28IPJ@1|root,2Z8PI@2|Bacteria,1N3K3@1224|Proteobacteria,42YFP@68525|delta/epsilon subdivisions,2WTSC@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_837215_2 553385.JEMF01000063_gene1587 1.65e-27 114.0 COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,1RQNB@1236|Gammaproteobacteria,1XJ7D@135619|Oceanospirillales 135619|Oceanospirillales O Xanthine dehydrogenase xdhC - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_837217_1 246197.MXAN_4597 8.31e-40 148.0 COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2Z1PP@29|Myxococcales 28221|Deltaproteobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM,TPR_14,TPR_16 k59_15742_1 999141.GME_10611 8.76e-91 282.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1XHK9@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_772587_1 572544.Ilyop_0015 4.26e-14 69.7 COG0193@1|root,COG0193@2|Bacteria,379XT@32066|Fusobacteria 32066|Fusobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_772587_2 572544.Ilyop_0018 2.15e-34 128.0 COG4656@1|root,COG4656@2|Bacteria,3791P@32066|Fusobacteria 32066|Fusobacteria C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4,Fer4_10,Fer4_17,Fer4_4,Fer4_7,RnfC_N,SLBB k59_609880_1 1168034.FH5T_07885 6.51e-46 166.0 COG0457@1|root,COG0457@2|Bacteria,4NDVW@976|Bacteroidetes,2FMY8@200643|Bacteroidia 976|Bacteroidetes NU Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_1001944_1 1321779.HMPREF1984_00632 3.09e-116 346.0 COG0151@1|root,COG0151@2|Bacteria,378PI@32066|Fusobacteria 32066|Fusobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_119183_1 693986.MOC_3768 1.22e-76 246.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,1JR3K@119045|Methylobacteriaceae 28211|Alphaproteobacteria I PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_280590_1 1127673.GLIP_0167 1.28e-33 130.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464DP@72275|Alteromonadaceae 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_280590_2 1403819.BATR01000168_gene5801 1.06e-30 121.0 COG0845@1|root,COG0845@2|Bacteria,46VEA@74201|Verrucomicrobia,2IUBR@203494|Verrucomicrobiae 203494|Verrucomicrobiae M HlyD family secretion protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_380474_1 1304885.AUEY01000072_gene1703 7.41e-95 293.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MI03@213118|Desulfobacterales 28221|Deltaproteobacteria EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657,ko:K13503 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_936434_1 1121405.dsmv_3125 9.94e-84 254.0 COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,42QAW@68525|delta/epsilon subdivisions,2WIXS@28221|Deltaproteobacteria,2MIY5@213118|Desulfobacterales 28221|Deltaproteobacteria D Belongs to the ParA family minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_936434_2 69042.WH5701_06105 1.87e-09 60.1 COG0850@1|root,COG0850@2|Bacteria,1G1JG@1117|Cyanobacteria,1H0R2@1129|Synechococcus 1117|Cyanobacteria D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization minC GO:0000910,GO:0007049,GO:0008150,GO:0009987,GO:0022402,GO:0032506,GO:0036214,GO:0051179,GO:0051301,GO:0061640 - ko:K03610 - - - - ko00000,ko03036,ko04812 - - - MinC_C k59_1033346_1 566466.NOR53_2748 9.48e-20 90.1 COG3568@1|root,COG3568@2|Bacteria,1RJZP@1224|Proteobacteria,1TH72@1236|Gammaproteobacteria,1JABN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_870077_1 1319815.HMPREF0202_00128 3.29e-65 212.0 COG2182@1|root,COG2182@2|Bacteria,37CDV@32066|Fusobacteria 32066|Fusobacteria G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 k59_51561_1 1168034.FH5T_06980 9.25e-96 288.0 COG1408@1|root,COG1408@2|Bacteria,4NFCH@976|Bacteroidetes,2FQ9F@200643|Bacteroidia 976|Bacteroidetes S Ser Thr phosphatase family protein - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_512622_1 95619.PM1_0226365 4.34e-100 305.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_412678_1 1249627.D779_0387 1.31e-124 372.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_51574_1 522306.CAP2UW1_0963 1.82e-59 204.0 COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,2VRWD@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase Tn5 dimerisation domain - - - - - - - - - - - - Dimer_Tnp_Tn5,Tnp_DNA_bind k59_1033352_1 1168034.FH5T_01430 1.68e-83 254.0 COG0451@1|root,COG0451@2|Bacteria,4NIZG@976|Bacteroidetes 976|Bacteroidetes GM Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_1033352_3 1469557.JSWF01000014_gene2428 0.000566 42.4 COG1595@1|root,COG1595@2|Bacteria,4NSVA@976|Bacteroidetes,1I0Q1@117743|Flavobacteriia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_544480_1 472759.Nhal_1431 1.13e-105 320.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1X2DF@135613|Chromatiales 135613|Chromatiales C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_675683_1 1123318.KB904632_gene1202 1.77e-47 160.0 arCOG09454@1|root,30G4A@2|Bacteria,1V448@1239|Firmicutes,4HHA0@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_512639_1 1229276.DI53_1185 4.95e-79 262.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1IVAK@117747|Sphingobacteriia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_870091_1 666685.R2APBS1_2752 8.75e-33 118.0 2E31J@1|root,32Y1Y@2|Bacteria,1N745@1224|Proteobacteria,1SCMM@1236|Gammaproteobacteria,1X8QA@135614|Xanthomonadales 135614|Xanthomonadales S MAPEG family - - - - - - - - - - - - MAPEG k59_870091_2 391615.ABSJ01000047_gene2121 9.75e-18 80.5 COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria 1224|Proteobacteria M Integral membrane protein CcmA involved in cell shape determination WS1240 - - - - - - - - - - - Bactofilin k59_936451_2 1150621.SMUL_0922 5.24e-59 187.0 COG1845@1|root,COG1845@2|Bacteria,1RI5A@1224|Proteobacteria,43B3F@68525|delta/epsilon subdivisions 1224|Proteobacteria C Cytochrome c oxidase subunit III coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_86123_1 1168034.FH5T_20580 8.36e-103 308.0 COG2207@1|root,COG5616@1|root,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - HTH_18 k59_86123_2 1168034.FH5T_20600 7.87e-30 117.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,4NEK3@976|Bacteroidetes,2FPEG@200643|Bacteroidia 976|Bacteroidetes C FAD binding domain - - - ko:K06911 - - - - ko00000 - - - FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8 k59_738592_1 207559.Dde_1184 2.36e-68 218.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKFV@28221|Deltaproteobacteria,2MG57@213115|Desulfovibrionales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component dppB - - ko:K02033,ko:K12369 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_185358_1 1168034.FH5T_14045 2.2e-54 174.0 293VW@1|root,2ZRB2@2|Bacteria,4NMK7@976|Bacteroidetes,2FUEE@200643|Bacteroidia 976|Bacteroidetes S Gliding motility-associated lipoprotein GldD gldD - - - - - - - - - - - - k59_185358_2 1121899.Q764_06210 3.11e-18 83.6 COG2091@1|root,COG2091@2|Bacteria,4NSBI@976|Bacteroidetes,1HYHB@117743|Flavobacteriia,2NTHU@237|Flavobacterium 976|Bacteroidetes H Belongs to the P-Pant transferase superfamily sfp - - - - - - - - - - - ACPS k59_477944_2 1250278.JQNQ01000001_gene404 2.8e-20 93.6 COG3064@1|root,COG3064@2|Bacteria,4NEVD@976|Bacteroidetes,1HWKC@117743|Flavobacteriia 976|Bacteroidetes M membrane - - - - - - - - - - - - PorP_SprF k59_675693_3 2340.JV46_04650 2.57e-49 169.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metallophosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_15791_1 396588.Tgr7_3035 6.69e-89 283.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1033355_2 679926.Mpet_1088 1.34e-35 143.0 COG0577@1|root,arCOG02315@2157|Archaea,2XYJU@28890|Euryarchaeota,2N9SS@224756|Methanomicrobia 224756|Methanomicrobia V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_1033355_3 202952.BBLI01000007_gene713 1.97e-53 189.0 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,3NM2I@468|Moraxellaceae 1236|Gammaproteobacteria V Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K05685 ko02010,map02010 M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k59_870107_1 715451.ambt_00005 1.32e-70 229.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,46444@72275|Alteromonadaceae 1236|Gammaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_445059_1 709032.Sulku_0052 9.64e-80 251.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2YMSH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c oxidase accessory protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_280642_1 1168034.FH5T_07105 3.41e-118 351.0 COG0477@1|root,COG2814@2|Bacteria,4NG5F@976|Bacteroidetes,2FP47@200643|Bacteroidia 976|Bacteroidetes EGP Major Facilitator ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - BT1,MFS_1 k59_738609_1 1049564.TevJSym_av00430 1.88e-145 422.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1J4CI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 ko:K02495 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R06895 RC00884 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403 HemN_C,Radical_SAM k59_968836_1 1123326.JFBL01000009_gene866 1.09e-106 321.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,42MG1@68525|delta/epsilon subdivisions,2YN29@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E amino acid carrier protein - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_936473_1 765912.Thimo_1660 2.12e-84 274.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1WWVT@135613|Chromatiales 135613|Chromatiales E PFAM peptidase M1, membrane alanine aminopeptidase pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_675707_1 572477.Alvin_2696 1.33e-84 260.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WXNS@135613|Chromatiales 135613|Chromatiales S PFAM von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA_2 k59_675707_2 765911.Thivi_2064 1.4e-05 46.2 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WVYS@135613|Chromatiales 135613|Chromatiales S PFAM von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_609945_1 1280689.AUJC01000004_gene392 1.18e-38 157.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,36DH7@31979|Clostridiaceae 186801|Clostridia L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_51605_1 522306.CAP2UW1_2791 3.31e-49 179.0 COG0642@1|root,COG0745@1|root,COG2198@1|root,COG3850@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KQ8J@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T histidine kinase A domain protein - - 2.7.13.3 ko:K07679 ko02020,ko05133,map02020,map05133 M00477 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,CHASE8,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_7,PAS_9,Response_reg k59_738612_1 1401078.HMPREF2140_11360 3.93e-21 92.8 COG5434@1|root,COG5434@2|Bacteria,4NGH3@976|Bacteroidetes,2FMQQ@200643|Bacteroidia 976|Bacteroidetes M Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF3737 k59_738612_2 1536772.R70723_11840 2.23e-46 159.0 COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,4H9PE@91061|Bacilli,26TMT@186822|Paenibacillaceae 91061|Bacilli E Cystathionine beta-lyase patB - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_512678_1 1168034.FH5T_00400 4.43e-38 135.0 COG0760@1|root,COG0760@2|Bacteria,4NG2P@976|Bacteroidetes,2FMWD@200643|Bacteroidia 976|Bacteroidetes O COG NOG23400 non supervised orthologous group - - - - - - - - - - - - Rotamase_2 k59_512678_2 1168034.FH5T_00405 1.09e-34 130.0 COG0760@1|root,COG0760@2|Bacteria,4NEW0@976|Bacteroidetes,2FMDU@200643|Bacteroidia 976|Bacteroidetes M peptidylprolyl isomerase surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N_3 k59_314110_1 391615.ABSJ01000054_gene1377 2.2e-85 266.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1J8US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_15818_1 1123284.KB899044_gene769 1.86e-08 53.9 COG1225@1|root,COG1225@2|Bacteria,1V058@1239|Firmicutes,4HE2H@91061|Bacilli 91061|Bacilli O Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin k59_15818_2 1461580.CCAS010000002_gene262 2.97e-21 93.6 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,4H9RU@91061|Bacilli,1ZBG0@1386|Bacillus 91061|Bacilli G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008973,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0034641,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme k59_445073_1 338966.Ppro_2077 9.44e-26 108.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42NGM@68525|delta/epsilon subdivisions,2WKBQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria P TonB-dependent Receptor Plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_15821_1 387093.SUN_0694 3.25e-20 87.4 COG2454@1|root,COG2454@2|Bacteria,1RM5I@1224|Proteobacteria,43BE1@68525|delta/epsilon subdivisions 1224|Proteobacteria S Protein of unknown function (DUF434) - - - - - - - - - - - - DUF434 k59_15821_2 387093.SUN_1447 3.31e-76 236.0 COG1234@1|root,COG1234@2|Bacteria,1Q4PW@1224|Proteobacteria,42PQE@68525|delta/epsilon subdivisions,2YNTI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_185386_2 1122621.ATZA01000057_gene4098 5.74e-24 97.8 COG1595@1|root,COG1595@2|Bacteria,4NNBY@976|Bacteroidetes,1IS89@117747|Sphingobacteriia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1002015_1 1121878.AUGL01000011_gene856 5.91e-53 179.0 COG0438@1|root,COG0438@2|Bacteria,1PDW1@1224|Proteobacteria,1RZIK@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Capsular polysaccharide biosynthesis protein - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_801857_1 644282.Deba_1466 6.36e-15 79.3 COG4591@1|root,COG4591@2|Bacteria 2|Bacteria M lipoprotein localization to outer membrane - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_1033381_1 1121403.AUCV01000028_gene2426 3.21e-16 77.8 COG3292@1|root,COG3292@2|Bacteria,1QMJ4@1224|Proteobacteria,42RQF@68525|delta/epsilon subdivisions,2WNII@28221|Deltaproteobacteria,2MPF0@213118|Desulfobacterales 28221|Deltaproteobacteria T Two component regulator propeller - - - - - - - - - - - - Tail_P2_I k59_1033381_2 1117108.PAALTS15_18183 5.82e-56 199.0 COG3299@1|root,COG3299@2|Bacteria 2|Bacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_15831_1 1168034.FH5T_19385 7.28e-103 311.0 COG2271@1|root,COG2271@2|Bacteria,4NF82@976|Bacteroidetes 976|Bacteroidetes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_185392_2 1168034.FH5T_14110 1.59e-61 194.0 COG0637@1|root,COG0637@2|Bacteria,4NEEH@976|Bacteroidetes,2FXP5@200643|Bacteroidia 976|Bacteroidetes S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_642517_1 768671.ThimaDRAFT_0736 8.59e-77 236.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1WWE2@135613|Chromatiales 135613|Chromatiales G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_772658_1 519989.ECTPHS_12913 1.16e-85 261.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales 135613|Chromatiales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_544546_1 314345.SPV1_06039 6.85e-11 67.8 2E15V@1|root,32WKS@2|Bacteria,1N30I@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_837932_1 292415.Tbd_1534 2.99e-52 181.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KRDI@119069|Hydrogenophilales 119069|Hydrogenophilales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_576968_1 1123519.PSJM300_14700 4.6e-15 80.1 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria,1Z1Z7@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_478010_1 1168034.FH5T_00095 1.39e-69 221.0 COG0681@1|root,COG0681@2|Bacteria,4NFTP@976|Bacteroidetes,2FNMS@200643|Bacteroidia 976|Bacteroidetes U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_478010_2 1168034.FH5T_00090 2.85e-27 105.0 COG0289@1|root,COG0289@2|Bacteria,4NDX2@976|Bacteroidetes,2FNUW@200643|Bacteroidia 976|Bacteroidetes E Belongs to the DapB family dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_744410_1 1122978.AUFP01000002_gene2221 3.65e-129 405.0 COG0675@1|root,COG0675@2|Bacteria 2|Bacteria L Transposase, IS605 OrfB family - - - ko:K07496 - - - - ko00000 - - - - k59_942415_1 118161.KB235919_gene6402 8.6e-80 254.0 2DMFF@1|root,32R5F@2|Bacteria,1GAQC@1117|Cyanobacteria 1117|Cyanobacteria S IMG reference gene - - - - - - - - - - - - - k59_908998_1 1168034.FH5T_07120 3.35e-93 278.0 COG3279@1|root,COG3279@2|Bacteria,4NFPV@976|Bacteroidetes,2FN7I@200643|Bacteroidia 976|Bacteroidetes T COG3279 Response regulator of the LytR AlgR family - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_159511_1 572477.Alvin_0776 1.22e-28 109.0 COG2840@1|root,COG2840@2|Bacteria,1MVS6@1224|Proteobacteria,1RPXD@1236|Gammaproteobacteria,1X2FW@135613|Chromatiales 135613|Chromatiales S PFAM Smr - - - - - - - - - - - - Smr k59_159511_2 395493.BegalDRAFT_1873 1.96e-30 114.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,46018@72273|Thiotrichales 72273|Thiotrichales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_387063_1 1283300.ATXB01000001_gene2439 1.07e-102 309.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,1RMRB@1236|Gammaproteobacteria,1XEA0@135618|Methylococcales 135618|Methylococcales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_286977_1 572477.Alvin_0841 2.84e-10 60.8 COG2153@1|root,COG2153@2|Bacteria,1N7TN@1224|Proteobacteria,1SCI6@1236|Gammaproteobacteria,1WYQK@135613|Chromatiales 135613|Chromatiales S protein acetylation - - - - - - - - - - - - - k59_286977_2 472759.Nhal_2114 2.33e-29 109.0 29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,1S6VD@1236|Gammaproteobacteria,1X0VV@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_191293_1 1034347.CAHJ01000065_gene3014 1.71e-33 120.0 COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,1ZGG0@1386|Bacillus 91061|Bacilli E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate gcvH GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_1007543_1 1116472.MGMO_29c00070 9.58e-68 225.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1XDJB@135618|Methylococcales 135618|Methylococcales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_583094_1 1049564.TevJSym_bd00140 6.78e-91 296.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_519056_1 593907.Celgi_2026 2.56e-99 294.0 COG2813@1|root,COG2813@2|Bacteria,2IFG7@201174|Actinobacteria,4F15C@85016|Cellulomonadaceae 201174|Actinobacteria J Methyltransferase small domain rsmC - 2.1.1.172 ko:K00564 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - MTS k59_519056_2 593907.Celgi_2029 4.4e-38 136.0 COG0253@1|root,COG0253@2|Bacteria,2GKUD@201174|Actinobacteria,4F0YQ@85016|Cellulomonadaceae 201174|Actinobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_57771_1 768671.ThimaDRAFT_2310 1.84e-85 264.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1WVX6@135613|Chromatiales 135613|Chromatiales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1007547_1 375286.mma_3509 1.28e-32 127.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,473CB@75682|Oxalobacteraceae 28216|Betaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_387081_1 936589.HMPREF1521_1437 6.04e-103 306.0 COG2877@1|root,COG2877@2|Bacteria,1TR2G@1239|Firmicutes,4H20D@909932|Negativicutes 909932|Negativicutes M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_418277_1 98439.AJLL01000016_gene1662 4.73e-66 231.0 COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1GBHA@1117|Cyanobacteria 1117|Cyanobacteria IQ Acyl transferase domain - - - ko:K15314 ko01059,ko01130,map01059,map01130 M00824,M00825 R11435 - ko00000,ko00001,ko00002,ko01008 - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_57781_2 187272.Mlg_0587 8.42e-28 113.0 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_483060_1 1168034.FH5T_18945 1.24e-167 481.0 COG0504@1|root,COG0504@2|Bacteria,4NEWT@976|Bacteroidetes,2FMC4@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_451642_1 1123392.AQWL01000008_gene1250 1.69e-08 53.9 2DZRC@1|root,32VGV@2|Bacteria,1PWQA@1224|Proteobacteria,2WC8T@28216|Betaproteobacteria,1KT99@119069|Hydrogenophilales 119069|Hydrogenophilales - - - - - - - - - - - - - - - k59_451642_2 1158182.KB905033_gene1632 5.5e-11 64.3 2C7AT@1|root,338A4@2|Bacteria,1NF74@1224|Proteobacteria,1SRBB@1236|Gammaproteobacteria,1X1A2@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_681546_1 1172190.M947_02655 4.13e-84 251.0 COG0775@1|root,COG0775@2|Bacteria,1R9VR@1224|Proteobacteria,42RM2@68525|delta/epsilon subdivisions,2YP67@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F phosphorylase - - - - - - - - - - - - PNP_UDP_1 k59_681546_2 1537917.JU82_00480 4.53e-120 347.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2YMH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth,NMO k59_92513_2 1122194.AUHU01000018_gene3462 8.19e-40 141.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,4645F@72275|Alteromonadaceae 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_159559_1 177437.HRM2_31630 1.77e-33 123.0 2CDHP@1|root,32RXU@2|Bacteria,1N1BP@1224|Proteobacteria,42TPT@68525|delta/epsilon subdivisions,2WQE6@28221|Deltaproteobacteria,2MJZK@213118|Desulfobacterales 28221|Deltaproteobacteria S RsbT co-antagonist protein rsbRD N-terminal domain - - - - - - - - - - - - RsbRD_N k59_807601_2 519441.Smon_1034 1.07e-226 639.0 COG1190@1|root,COG1190@2|Bacteria,37904@32066|Fusobacteria 32066|Fusobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_191317_1 1249480.B649_05400 1.27e-146 427.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2YMGS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_681551_1 402881.Plav_2705 1.54e-82 261.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,1JNNJ@119043|Rhodobiaceae 28211|Alphaproteobacteria C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_681551_2 913325.N799_07370 1.09e-14 73.6 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria,1X3DR@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_744463_1 794903.OPIT5_24275 1.01e-56 193.0 COG4108@1|root,COG4108@2|Bacteria,46SF9@74201|Verrucomicrobia,3K7C8@414999|Opitutae 414999|Opitutae J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_57796_1 1125863.JAFN01000001_gene415 4.63e-92 276.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WJHD@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Pterin binding enzyme - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_974482_1 626418.bglu_1g29760 1.91e-10 66.2 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,1K1Z0@119060|Burkholderiaceae 28216|Betaproteobacteria G fructose-bisphosphate aldolase, class II, Calvin cycle subtype fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_354571_1 1035308.AQYY01000001_gene3242 6.42e-23 102.0 COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,25B73@186801|Clostridia,263UP@186807|Peptococcaceae 186801|Clostridia K PFAM Bacterial regulatory proteins, luxR family - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE k59_713277_1 391625.PPSIR1_12068 1.54e-28 112.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2YV33@29|Myxococcales 28221|Deltaproteobacteria E Threonine dehydratase - - 4.3.1.17,4.3.1.19 ko:K17989 ko00260,ko00270,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00590,R00996 RC00331,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_713277_2 570967.JMLV01000002_gene1749 1.59e-09 58.2 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,2JPBX@204441|Rhodospirillales 204441|Rhodospirillales P COG0530 Ca2 Na antiporter - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_418295_1 1265503.KB905166_gene674 2.76e-29 119.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,2Q7IA@267889|Colwelliaceae 1236|Gammaproteobacteria I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_319651_1 1122201.AUAZ01000004_gene3394 3.39e-109 337.0 COG0732@1|root,COG5113@1|root,COG0732@2|Bacteria,COG3236@2|Bacteria,1Q4FB@1224|Proteobacteria,1RS7D@1236|Gammaproteobacteria,46823@72275|Alteromonadaceae 1236|Gammaproteobacteria V restriction modification system DNA specificity hsdS - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_57799_1 1279009.ADICEAN_02186 1.41e-26 119.0 COG2885@1|root,COG2885@2|Bacteria,4NEND@976|Bacteroidetes,47KG7@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - OmpA,PD40 k59_191330_1 1056512.D515_00302 0.000111 45.4 COG0226@1|root,COG0226@2|Bacteria,1N7RX@1224|Proteobacteria,1SCQW@1236|Gammaproteobacteria,1XZ44@135623|Vibrionales 135623|Vibrionales P ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - - k59_191330_2 1304885.AUEY01000005_gene895 1e-23 100.0 COG3203@1|root,COG3203@2|Bacteria,1PJNW@1224|Proteobacteria,42TCM@68525|delta/epsilon subdivisions,2WPPQ@28221|Deltaproteobacteria,2MNBT@213118|Desulfobacterales 28221|Deltaproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_909017_1 32024.JMTI01000002_gene687 4.7e-16 74.7 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_223653_1 330214.NIDE2030 5.56e-22 103.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria 2|Bacteria S CHAT domain - - - - - - - - - - - - CHAT,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8 k59_550727_1 1499967.BAYZ01000182_gene4473 8.18e-41 143.0 COG0226@1|root,COG0226@2|Bacteria 2|Bacteria P phosphate ion binding - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_418300_1 1123367.C666_03715 1.22e-45 154.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VPW8@28216|Betaproteobacteria,2KVSD@206389|Rhodocyclales 206389|Rhodocyclales C Heme copper-type cytochrome quinol oxidase, subunit 3 - - - ko:K02164 - - R00294 RC02794 ko00000 3.D.4.10 - - COX3 k59_418300_2 1123368.AUIS01000008_gene2149 6.56e-08 51.2 2BKCK@1|root,32ET5@2|Bacteria,1NI55@1224|Proteobacteria,1SVED@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Prokaryotic Cytochrome C oxidase subunit IV - - - - - - - - - - - - COX4_pro k59_778656_1 985665.HPL003_24065 1.21e-29 120.0 COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,4HAN2@91061|Bacilli,26QBK@186822|Paenibacillaceae 91061|Bacilli L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_1039913_1 1255043.TVNIR_2413 4.62e-41 144.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales 135613|Chromatiales S Methyltransferase - - 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 k59_744982_1 519989.ECTPHS_13233 1.62e-24 97.1 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales 135613|Chromatiales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_744982_2 498211.CJA_0689 4e-43 147.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1FH1V@10|Cellvibrio 1236|Gammaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_92940_2 908937.Prede_1332 0.000201 50.4 COG4974@1|root,COG4974@2|Bacteria,4NE0E@976|Bacteroidetes,2FP3B@200643|Bacteroidia 976|Bacteroidetes D tyrosine recombinase XerC xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_808091_1 1485545.JQLW01000006_gene350 1.19e-42 152.0 COG1985@1|root,COG1985@2|Bacteria,1RDMT@1224|Proteobacteria 1224|Proteobacteria H RibD C-terminal domain - - - - - - - - - - - - RibD_C k59_387789_1 1245469.S58_21480 1.22e-20 95.5 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,3JRFI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_355157_1 927658.AJUM01000047_gene2819 2.35e-33 124.0 COG3295@1|root,COG3295@2|Bacteria,4NNGT@976|Bacteroidetes,2FNIB@200643|Bacteroidia,3XKEK@558415|Marinilabiliaceae 976|Bacteroidetes S Putative PepSY_TM-like - - - ko:K09939 - - - - ko00000 - - - PepSY_TM_like_2 k59_355157_2 1168034.FH5T_18760 6.75e-12 63.2 29TPU@1|root,30EXX@2|Bacteria,4NPRV@976|Bacteroidetes,2FNJR@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_843980_1 869213.JCM21142_104 1.88e-19 86.3 COG2846@1|root,COG2846@2|Bacteria,4NPQ7@976|Bacteroidetes,47QJX@768503|Cytophagia 976|Bacteroidetes D Di-iron-containing protein involved in the repair of iron-sulfur clusters - - - ko:K07322 - - - - ko00000 - - - Hemerythrin k59_843980_2 1038859.AXAU01000002_gene476 1.91e-06 51.6 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,3JT8S@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_224289_1 1049564.TevJSym_bh00320 2.4e-88 268.0 COG0583@1|root,COG0583@2|Bacteria,1MUWX@1224|Proteobacteria,1RYWC@1236|Gammaproteobacteria,1JB8E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_583714_1 396588.Tgr7_3010 1.57e-116 348.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales 135613|Chromatiales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_616357_1 316274.Haur_4692 1.18e-12 68.2 COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,376AC@32061|Chloroflexia 32061|Chloroflexia J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_616357_2 997346.HMPREF9374_3008 0.000759 45.8 COG0805@1|root,COG0805@2|Bacteria,1U7N7@1239|Firmicutes,4HB1U@91061|Bacilli,27BT4@186824|Thermoactinomycetaceae 91061|Bacilli U Sec-independent protein translocase protein (TatC) tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_519631_1 1156937.MFUM_310009 6.86e-101 317.0 COG0433@1|root,COG0433@2|Bacteria,46WEP@74201|Verrucomicrobia 74201|Verrucomicrobia S Domain of unknown function DUF87 - - - - - - - - - - - - DUF87 k59_387791_1 1120953.AUBH01000007_gene1858 3.98e-09 57.8 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,465QS@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the agmatine deiminase family aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_387791_2 876044.IMCC3088_182 1.24e-79 244.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,1J55I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S amidohydrolase aguB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_808097_1 96561.Dole_0088 3.73e-28 111.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2WIM4@28221|Deltaproteobacteria,2MI7D@213118|Desulfobacterales 28221|Deltaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_808097_2 278957.ABEA03000047_gene1280 1.46e-19 87.0 COG1057@1|root,COG1057@2|Bacteria,46T27@74201|Verrucomicrobia,3K85U@414999|Opitutae 414999|Opitutae H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_191920_2 335543.Sfum_3887 1.4e-37 133.0 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,42U8K@68525|delta/epsilon subdivisions,2WQZR@28221|Deltaproteobacteria 28221|Deltaproteobacteria K RNA polymerase sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_909525_1 391612.CY0110_04942 3.53e-11 68.9 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1G2A0@1117|Cyanobacteria,3KGBY@43988|Cyanothece 1117|Cyanobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,PAS_4,Response_reg k59_224298_1 1485545.JQLW01000007_gene839 7e-80 262.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria 1224|Proteobacteria L Atp-dependent helicase hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_943119_1 1249480.B649_02260 3.81e-44 148.0 COG1214@1|root,COG1214@2|Bacteria,1Q1J6@1224|Proteobacteria,42TUF@68525|delta/epsilon subdivisions,2YQ3R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG1214 Inactive homolog of metal-dependent proteases tsaB - - - - - - - - - - - - k59_943119_2 563040.Saut_0700 1.14e-142 407.0 COG0083@1|root,COG0083@2|Bacteria,1MW8I@1224|Proteobacteria,42M9H@68525|delta/epsilon subdivisions,2YMZ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1040441_1 1168034.FH5T_14130 2.81e-151 427.0 COG3298@1|root,COG3298@2|Bacteria,4NECH@976|Bacteroidetes,2FRZP@200643|Bacteroidia 976|Bacteroidetes L Predicted 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_452451_1 588581.Cpap_0003 1.46e-126 389.0 COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,3WSTF@541000|Ruminococcaceae 186801|Clostridia Q Beta-ketoacyl synthase - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_418838_1 1168034.FH5T_06135 4e-71 229.0 COG2956@1|root,COG2956@2|Bacteria,4PNWA@976|Bacteroidetes,2G0ZI@200643|Bacteroidia 976|Bacteroidetes G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane - - - - - - - - - - - - TPR_16 k59_418838_2 1168034.FH5T_06130 1.47e-20 88.2 COG3117@1|root,COG3117@2|Bacteria,4NSXY@976|Bacteroidetes,2G2BC@200643|Bacteroidia 976|Bacteroidetes S Lipopolysaccharide-assembly, LptC-related - - - - - - - - - - - - LptC k59_483670_1 395494.Galf_1307 1.07e-58 204.0 COG0642@1|root,COG0784@1|root,COG3850@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE5,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_713844_1 411154.GFO_1836 6.01e-18 89.7 COG1520@1|root,COG2304@1|root,COG2911@1|root,COG3209@1|root,COG1520@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ7S@117743|Flavobacteriia 976|Bacteroidetes M SPTR CHU large protein - - - - - - - - - - - - CHU_C,Calx-beta,DUF11,HYR,SprB k59_1008164_1 706587.Desti_2853 4.03e-72 229.0 COG0715@1|root,COG0715@2|Bacteria,1RKKF@1224|Proteobacteria,43AHB@68525|delta/epsilon subdivisions,2X5XF@28221|Deltaproteobacteria,2MRET@213462|Syntrophobacterales 28221|Deltaproteobacteria P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_943154_1 879212.DespoDRAFT_01971 3.08e-39 135.0 COG0138@1|root,COG0138@2|Bacteria,1N2UC@1224|Proteobacteria,42NFS@68525|delta/epsilon subdivisions,2X5JJ@28221|Deltaproteobacteria,2MIV7@213118|Desulfobacterales 28221|Deltaproteobacteria F MGS-like domain - - - - - - - - - - - - AICARFT_IMPCHas,MGS k59_943154_2 1121396.KB892902_gene2341 1.66e-100 301.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MI2I@213118|Desulfobacterales 28221|Deltaproteobacteria F PFAM AICARFT IMPCHase bienzyme purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_224316_1 1123242.JH636437_gene6091 7.33e-90 286.0 COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes 203682|Planctomycetes L AAA-like domain - - - - - - - - - - - - DUF853,DUF87,PDDEXK_1 k59_287563_1 1122599.AUGR01000006_gene3911 8.35e-65 214.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,1S01Y@1236|Gammaproteobacteria,1XIYH@135619|Oceanospirillales 135619|Oceanospirillales T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 k59_418845_1 1449049.JONW01000005_gene1013 1.76e-52 188.0 COG1629@1|root,COG1629@2|Bacteria,1QUTW@1224|Proteobacteria,2TW7F@28211|Alphaproteobacteria,2KFR5@204458|Caulobacterales 204458|Caulobacterales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_224318_1 42256.RradSPS_2487 1.54e-48 169.0 COG1914@1|root,COG1914@2|Bacteria,2GJSM@201174|Actinobacteria 201174|Actinobacteria P H( )-stimulated, divalent metal cation uptake system - - - - - - - - - - - - Nramp k59_387818_1 105559.Nwat_2797 3.88e-21 93.6 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WZYZ@135613|Chromatiales 135613|Chromatiales C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_850623_1 387093.SUN_1701 2.9e-74 242.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2YMN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA_synt_2f k59_98771_1 1268240.ATFI01000001_gene3584 3.67e-78 250.0 COG5520@1|root,COG5520@2|Bacteria,4NEG7@976|Bacteroidetes,2FMDC@200643|Bacteroidia,4AM41@815|Bacteroidaceae 976|Bacteroidetes M COG NOG07608 non supervised orthologous group - - - - - - - - - - - - Glyco_hydr_30_2,Glyco_hydro_30C k59_621795_1 362418.IW19_11440 4.09e-29 112.0 2FATS@1|root,34310@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_654524_1 1255043.TVNIR_3026 2.12e-119 356.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales 135613|Chromatiales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_360324_1 545264.KB898752_gene2397 2.14e-108 326.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_817871_1 1168034.FH5T_12595 8.13e-94 278.0 COG1595@1|root,COG1595@2|Bacteria,4NQCH@976|Bacteroidetes,2G2VX@200643|Bacteroidia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_817871_2 1168034.FH5T_12600 2.95e-13 70.1 COG3266@1|root,COG3266@2|Bacteria,4NH1U@976|Bacteroidetes,2FUGU@200643|Bacteroidia 976|Bacteroidetes S domain, Protein - - - - - - - - - - - - OMP_b-brl_2 k59_752622_1 596151.DesfrDRAFT_0663 1.42e-28 120.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,42RM3@68525|delta/epsilon subdivisions,2WNTS@28221|Deltaproteobacteria,2MBCV@213115|Desulfovibrionales 28221|Deltaproteobacteria K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_393032_1 927658.AJUM01000034_gene47 1.65e-06 55.1 COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria,4NDWS@976|Bacteroidetes,2FNCU@200643|Bacteroidia,3XJ48@558415|Marinilabiliaceae 976|Bacteroidetes KMT Gram-negative bacterial TonB protein C-terminal - - - - - - - - - - - - CarbopepD_reg_2,Peptidase_M56,Plug,TonB_C k59_425596_1 1168034.FH5T_10905 2.19e-40 141.0 COG0657@1|root,COG0657@2|Bacteria,4NWD5@976|Bacteroidetes 976|Bacteroidetes I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 k59_425596_2 869213.JCM21142_1583 4.59e-31 117.0 COG2188@1|root,COG2188@2|Bacteria,4NFVY@976|Bacteroidetes,47QHR@768503|Cytophagia 976|Bacteroidetes K UTRA domain - - - ko:K03710,ko:K10711 - - - - ko00000,ko03000 - - - GntR,UTRA k59_327685_1 251229.Chro_0270 6.4e-55 182.0 COG2084@1|root,COG2084@2|Bacteria,1G34X@1117|Cyanobacteria,3VN43@52604|Pleurocapsales 1117|Cyanobacteria I PFAM NAD binding domain of 6-phosphogluconate dehydrogenase mmsB - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_327685_2 999541.bgla_1g28130 8.15e-05 43.9 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,2VHS8@28216|Betaproteobacteria,1K22V@119060|Burkholderiaceae 28216|Betaproteobacteria M aspartate racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_785175_1 1190606.AJYG01000193_gene2568 4.83e-103 319.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1XSIF@135623|Vibrionales 135623|Vibrionales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity - - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_262197_1 935557.ATYB01000014_gene2055 5.55e-25 108.0 COG1361@1|root,COG2911@1|root,COG2931@1|root,COG2982@1|root,COG3210@1|root,COG4935@1|root,COG1361@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,COG4935@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4BB16@82115|Rhizobiaceae 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4214,DUF4347,HCBP_related,He_PIG,HemolysinCabind,Metallophos,P_proprotein,Peptidase_S8 k59_458371_1 439235.Dalk_3266 2.94e-58 203.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_752624_1 888055.HMPREF9015_00681 1.1e-17 79.3 COG0634@1|root,COG0634@2|Bacteria,37A35@32066|Fusobacteria 32066|Fusobacteria F Belongs to the purine pyrimidine phosphoribosyltransferase family - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_752624_2 572544.Ilyop_1319 3.51e-100 293.0 COG0634@1|root,COG0634@2|Bacteria,37A35@32066|Fusobacteria 32066|Fusobacteria F Belongs to the purine pyrimidine phosphoribosyltransferase family - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_752624_3 1319815.HMPREF0202_00290 4.12e-30 118.0 COG2815@1|root,COG2815@2|Bacteria,379UD@32066|Fusobacteria 32066|Fusobacteria S PASTA - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA k59_538_2 709032.Sulku_2204 9.7e-86 269.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,42P0P@68525|delta/epsilon subdivisions,2YN3S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Na H antiporter nhaC - - - - - - - - - - - Na_H_antiporter k59_654542_2 1165841.SULAR_07213 3.96e-44 156.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2YM91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_490957_1 439481.Aboo_1327 2.08e-14 74.7 COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,3F2TR@33867|unclassified Euryarchaeota 28890|Euryarchaeota J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_164213_1 1095769.CAHF01000011_gene2160 4.08e-42 154.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VMP7@28216|Betaproteobacteria,472JZ@75682|Oxalobacteraceae 28216|Betaproteobacteria E Amino acid permease steT - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_327704_1 765912.Thimo_1968 7.17e-117 352.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales 135613|Chromatiales CI TIGRFAM Oxaloacetate decarboxylase, alpha subunit - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_262205_1 443144.GM21_0435 3.65e-37 143.0 COG1361@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria 28221|Deltaproteobacteria M TIGRFAM conserved repeat domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_752633_1 396588.Tgr7_2267 1.42e-110 332.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_948648_1 686578.AFFX01000002_gene568 8.5e-30 113.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfC GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_523771_1 1165841.SULAR_00080 7.87e-183 521.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2YMF3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_196841_1 387093.SUN_2197 4.82e-63 201.0 COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42RBN@68525|delta/epsilon subdivisions,2YP23@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the 'phage' integrase family - - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_458398_1 1007104.SUS17_2533 3.53e-06 51.2 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2TR6D@28211|Alphaproteobacteria,2K0QP@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_458398_2 926692.AZYG01000094_gene1952 4.59e-06 50.4 COG2199@1|root,COG3706@2|Bacteria,1TT1S@1239|Firmicutes,24HUD@186801|Clostridia,3WBGJ@53433|Halanaerobiales 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GAF,GGDEF k59_229604_1 349521.HCH_02442 2.75e-137 403.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1XHAH@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_654558_1 1168034.FH5T_11525 3.28e-138 395.0 COG0030@1|root,COG0030@2|Bacteria,4NERB@976|Bacteroidetes,2FMH1@200643|Bacteroidia 976|Bacteroidetes J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_850645_1 1165841.SULAR_09944 2.58e-145 428.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,42KZC@68525|delta/epsilon subdivisions,2YM82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_425630_1 1123057.P872_21235 1.15e-66 211.0 COG0508@1|root,COG0508@2|Bacteria 2|Bacteria C S-acyltransferase activity - - 2.3.1.12,2.7.11.1,3.6.4.13 ko:K00627,ko:K03310,ko:K03578,ko:K12132 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko01001 2.A.25 - - 2-oxoacid_dh,Biotin_lipoyl k59_490971_1 203275.BFO_0423 0.000193 48.9 COG2067@1|root,COG2067@2|Bacteria,4NFS7@976|Bacteroidetes,2FM7S@200643|Bacteroidia,22WCW@171551|Porphyromonadaceae 976|Bacteroidetes I Outer membrane protein transport protein, Ompp1 FadL TodX - - - - - - - - - - - - Toluene_X k59_131431_1 396588.Tgr7_0118 5.25e-162 461.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales 135613|Chromatiales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_262222_1 387093.SUN_0546 4.73e-149 427.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2YMC0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_196850_1 452637.Oter_3677 4.77e-127 386.0 COG1148@1|root,COG1148@2|Bacteria 2|Bacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Pyr_redox_2 k59_1014091_1 667014.Thein_2028 3.65e-07 57.4 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - PMT_2 k59_425638_3 667632.KB890179_gene152 2.77e-06 47.8 COG3620@1|root,COG3620@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - DUF4870,HTH_3,HTH_31 k59_916064_1 870187.Thini_3059 2.89e-85 268.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,45ZT8@72273|Thiotrichales 72273|Thiotrichales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_817919_1 572480.Arnit_1195 2.03e-105 307.0 COG4843@1|root,COG4843@2|Bacteria,1REIP@1224|Proteobacteria,42S29@68525|delta/epsilon subdivisions,2YPB7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S UPF0316 protein - - - - - - - - - - - - DUF2179 k59_294950_1 762982.HMPREF9442_02505 5.13e-15 80.1 COG2335@1|root,COG2335@2|Bacteria,4NUVQ@976|Bacteroidetes,2FRKE@200643|Bacteroidia 976|Bacteroidetes M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin k59_458417_1 218284.CCDN010000001_gene791 2.54e-05 48.1 COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,4HAB1@91061|Bacilli,1ZBQ5@1386|Bacillus 91061|Bacilli P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstBA - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_458417_2 1249480.B649_11315 3.89e-49 167.0 COG0577@1|root,COG0577@2|Bacteria,1QT4V@1224|Proteobacteria,42P7K@68525|delta/epsilon subdivisions,2YNGD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter permease - - - - - - - - - - - - FtsX,MacB_PCD k59_33472_1 1321779.HMPREF1984_00045 5.26e-52 179.0 COG0770@1|root,COG0770@2|Bacteria,378TN@32066|Fusobacteria 32066|Fusobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Hydrolase_like,Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_33472_2 572544.Ilyop_1859 3.87e-89 266.0 COG0241@1|root,COG0241@2|Bacteria,37A6Q@32066|Fusobacteria 32066|Fusobacteria E D,D-heptose 1,7-bisphosphate phosphatase gmhB - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like k59_229623_1 1144275.COCOR_07125 2e-29 115.0 COG3716@1|root,COG3716@2|Bacteria,1MWTZ@1224|Proteobacteria,42SXR@68525|delta/epsilon subdivisions,2WPQN@28221|Deltaproteobacteria 28221|Deltaproteobacteria G system, mannose fructose sorbose family, IID component - - - ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EIID-AGA k59_556460_1 1278309.KB907100_gene1894 2.31e-12 65.9 COG2365@1|root,COG2365@2|Bacteria,1RGE7@1224|Proteobacteria,1SBQH@1236|Gammaproteobacteria,1XPA6@135619|Oceanospirillales 135619|Oceanospirillales T Tyrosine phosphatase family - - - - - - - - - - - - Y_phosphatase2 k59_556460_5 944547.ABLL_2136 1.96e-62 206.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2YN13@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_785220_1 1279038.KB907340_gene1476 1.61e-27 111.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JPVQ@204441|Rhodospirillales 204441|Rhodospirillales E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - - ko:K11076 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - ABC_tran,TOBE_2 k59_785220_2 1238182.C882_2562 4.23e-39 142.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2TSFD@28211|Alphaproteobacteria,2JQTE@204441|Rhodospirillales 204441|Rhodospirillales E Putrescine transport system permease potH - - ko:K11075 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_883386_1 870187.Thini_0877 1.04e-82 264.0 COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,1SKBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_33473_2 710421.Mycch_1117 3.43e-26 107.0 COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,234AX@1762|Mycobacteriaceae 201174|Actinobacteria E oxidoreductase choD GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N k59_1014097_2 469617.FUAG_00296 1.67e-21 92.8 COG5522@1|root,COG5522@2|Bacteria,37951@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - Intg_mem_TP0381 k59_719909_1 326298.Suden_1172 7.54e-20 83.2 COG1576@1|root,COG1576@2|Bacteria,1N7WB@1224|Proteobacteria,42V41@68525|delta/epsilon subdivisions,2YP43@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_719909_2 709032.Sulku_1130 2.6e-67 209.0 COG0352@1|root,COG0352@2|Bacteria,1Q57E@1224|Proteobacteria,42T8S@68525|delta/epsilon subdivisions,2YPQM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Thiamine monophosphate synthase thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_196863_2 1249480.B649_06995 5.44e-58 191.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,42P89@68525|delta/epsilon subdivisions,2YN9D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NifD NifK NifE NifN family - - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_817929_1 326297.Sama_2803 6.21e-06 52.0 2DNTA@1|root,32Z1C@2|Bacteria,1NCZW@1224|Proteobacteria,1SDTR@1236|Gammaproteobacteria,2QBY6@267890|Shewanellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_360399_1 1254432.SCE1572_04735 3.04e-37 133.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,42SVA@68525|delta/epsilon subdivisions,2WPFH@28221|Deltaproteobacteria,2Z1X4@29|Myxococcales 28221|Deltaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_360399_2 323848.Nmul_A2462 1.46e-18 85.9 COG0705@1|root,COG0705@2|Bacteria,1PRTS@1224|Proteobacteria,2VM82@28216|Betaproteobacteria,372KP@32003|Nitrosomonadales 28216|Betaproteobacteria S Rhomboid family - - 3.4.21.105 ko:K19225 - - - - ko00000,ko01000,ko01002 - - - Lactonase,Rhomboid k59_785228_1 264198.Reut_B4982 6.56e-72 233.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2VH45@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfate transporter sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_916080_2 1317124.DW2_11965 1.58e-83 255.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria,2XMGV@285107|Thioclava 28211|Alphaproteobacteria U ABC transporter permease dppB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K12369 ko02010,map02010 M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_98842_1 227086.JGI_V11_128614 1.18e-08 58.2 COG1073@1|root,KOG1552@2759|Eukaryota 2759|Eukaryota O palmitoyl-(protein) hydrolase activity - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4,Peptidase_S9 k59_196864_1 985053.VMUT_0520 1.52e-28 116.0 COG0492@1|root,arCOG01296@2157|Archaea,2XPQC@28889|Crenarchaeota 28889|Crenarchaeota O PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_459028_4 573413.Spirs_0820 3.94e-28 113.0 COG1879@1|root,COG1879@2|Bacteria,2J6MC@203691|Spirochaetes 203691|Spirochaetes G COG1879 ABC-type sugar transport system periplasmic component - - - ko:K10439,ko:K10540,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00214,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3 - - Peripla_BP_4 k59_99363_1 391615.ABSJ01000050_gene1178 6.05e-54 188.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J7Q2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Bacterial type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_818504_1 457570.Nther_1166 1.05e-59 198.0 COG3804@1|root,COG3804@2|Bacteria,1TRNF@1239|Firmicutes,249AS@186801|Clostridia 186801|Clostridia S dihydrodipicolinate reductase - - 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 - R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 - - - DapB_N k59_361022_1 391937.NA2_17157 9.34e-52 176.0 COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,43JBN@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 - R11018 RC00006 ko00000,ko00001,ko01000 - - - DAO k59_753159_1 1268068.PG5_46740 7.85e-37 137.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Permease lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_851332_1 1168034.FH5T_12095 1.79e-34 131.0 COG0317@1|root,COG0317@2|Bacteria,4NESY@976|Bacteroidetes,2FMEE@200643|Bacteroidia 976|Bacteroidetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_851332_2 1408473.JHXO01000011_gene3054 8.07e-84 249.0 COG0735@1|root,COG0735@2|Bacteria,4NM8S@976|Bacteroidetes,2FN4T@200643|Bacteroidia 976|Bacteroidetes P Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_687802_1 1408439.JHXW01000002_gene649 8.27e-74 242.0 COG0272@1|root,COG0272@2|Bacteria,3793I@32066|Fusobacteria 32066|Fusobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_593199_2 387093.SUN_0826 4.03e-75 233.0 COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,42V3C@68525|delta/epsilon subdivisions,2YQCX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M NlpC/P60 family - - 3.4.17.13 ko:K13694,ko:K13695 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,SPOR k59_528822_1 1165841.SULAR_07830 1.09e-11 64.7 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,42NWR@68525|delta/epsilon subdivisions,2YPQJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_528822_2 1165841.SULAR_07825 9.1e-43 147.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,42NWR@68525|delta/epsilon subdivisions,2YPQJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U MotA TolQ ExbB proton channel - - - - - - - - - - - - MotA_ExbB k59_756547_1 446469.Sked_16080 1.13e-37 141.0 28PUQ@1|root,2ZCFK@2|Bacteria,2GNQM@201174|Actinobacteria 201174|Actinobacteria S DNA-binding protein - GO:0008150,GO:0040007 - - - - - - - - - - DUF3071 k59_103745_1 596315.HMPREF0634_0895 5.52e-32 122.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,25SFC@186804|Peptostreptococcaceae 186801|Clostridia HP ATPases associated with a variety of cellular activities fhuC - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_234180_1 929556.Solca_4086 2.58e-40 146.0 COG1044@1|root,COG1044@2|Bacteria,4NE5G@976|Bacteroidetes,1IP38@117747|Sphingobacteriia 976|Bacteroidetes M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_429662_1 880526.KE386488_gene1758 6e-13 70.5 COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,2FWPB@200643|Bacteroidia,22VQT@171550|Rikenellaceae 976|Bacteroidetes E Peptidase family M28 pepD_2 - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_429662_2 754476.Q7A_1322 4.02e-35 147.0 COG2199@1|root,COG4251@1|root,COG3706@2|Bacteria,COG4251@2|Bacteria,1R7HC@1224|Proteobacteria,1T2WX@1236|Gammaproteobacteria,462NY@72273|Thiotrichales 72273|Thiotrichales T Diguanylate cyclase - - - - - - - - - - - - GAF,GGDEF,PAS_2,PHY k59_70606_1 1190603.AJYD01000097_gene2426 2.2e-32 123.0 COG4671@1|root,COG4671@2|Bacteria,1QUFP@1224|Proteobacteria,1T1XC@1236|Gammaproteobacteria,1XTDK@135623|Vibrionales 135623|Vibrionales S COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase - - - - - - - - - - - - Glyco_trans_1_3 k59_70606_2 983545.Glaag_0215 8.23e-09 55.8 COG0671@1|root,COG0671@2|Bacteria,1RJ1T@1224|Proteobacteria,1SAU1@1236|Gammaproteobacteria,466ER@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG0671 Membrane-associated phospholipid phosphatase - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k59_1018710_1 1168034.FH5T_04710 1.91e-106 312.0 COG0705@1|root,COG0705@2|Bacteria,4NIYR@976|Bacteroidetes,2FNMJ@200643|Bacteroidia 976|Bacteroidetes S Peptidase, S54 family - - 3.4.21.105 ko:K09650 - - - - ko00000,ko01000,ko01002,ko03029 - - - Rhomboid k59_887244_1 1140001.I571_01292 3.24e-06 47.4 COG2824@1|root,COG2824@2|Bacteria,1V6NA@1239|Firmicutes,4HIKN@91061|Bacilli,4B36I@81852|Enterococcaceae 91061|Bacilli P PhnA Zinc-Ribbon phnA - - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k59_397648_1 177437.HRM2_44390 1.61e-102 303.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,42NJR@68525|delta/epsilon subdivisions,2WKAM@28221|Deltaproteobacteria,2MJHK@213118|Desulfobacterales 28221|Deltaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_299075_1 572480.Arnit_1486 1.93e-19 97.4 COG2304@1|root,COG4254@1|root,COG2304@2|Bacteria,COG4254@2|Bacteria,1QU09@1224|Proteobacteria 1224|Proteobacteria M regulator of chromosome condensation, RCC1 - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Cadherin,He_PIG,RHS_repeat k59_332593_1 1260251.SPISAL_00115 7.32e-20 84.7 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales 135613|Chromatiales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_365034_1 1229205.BUPH_06321 3.8e-177 537.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae 28216|Betaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_37579_1 487796.Flav2ADRAFT_1239 3.83e-23 101.0 COG0476@1|root,COG0476@2|Bacteria,4NFUD@976|Bacteroidetes,1HYQ3@117743|Flavobacteriia 976|Bacteroidetes H involved in molybdopterin and thiamine biosynthesis family 2 - - 2.7.7.80,2.8.1.11 ko:K21029,ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF k59_887248_1 426114.THI_0135 7.62e-96 291.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,1KJRD@119065|unclassified Burkholderiales 28216|Betaproteobacteria H RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_887248_2 525909.Afer_0120 3.94e-07 48.9 COG4451@1|root,COG4451@2|Bacteria,2IIFC@201174|Actinobacteria,4CP24@84992|Acidimicrobiia 84992|Acidimicrobiia C Ribulose bisphosphate carboxylase, small chain - - 4.1.1.39 ko:K01602 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_small k59_691785_1 998674.ATTE01000001_gene1775 3.07e-100 301.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,45ZRK@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_691785_2 1380387.JADM01000018_gene3357 8.04e-06 46.6 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1XIZA@135619|Oceanospirillales 135619|Oceanospirillales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_953123_1 572544.Ilyop_0382 1.05e-58 199.0 COG0845@1|root,COG0845@2|Bacteria,378RU@32066|Fusobacteria 32066|Fusobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_3 k59_724291_1 243233.MCA0195 5.4e-85 265.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1XE7S@135618|Methylococcales 135618|Methylococcales S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_103770_2 936455.KI421499_gene4837 7.57e-17 83.6 COG2199@1|root,COG3706@2|Bacteria,1MX83@1224|Proteobacteria,2U3QQ@28211|Alphaproteobacteria,3JWJP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Cache domain - - - - - - - - - - - - GGDEF,dCache_1 k59_789739_1 156889.Mmc1_0392 4.13e-69 219.0 COG3439@1|root,COG3439@2|Bacteria,1RBWN@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - - k59_70626_1 944547.ABLL_1446 7.96e-107 330.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria 1224|Proteobacteria P Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_691793_1 1120951.AUBG01000006_gene525 2.43e-14 73.6 2E129@1|root,32WI1@2|Bacteria,4NSEA@976|Bacteroidetes,1I4QV@117743|Flavobacteriia 976|Bacteroidetes S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_691793_2 1175306.GWL_33150 4.04e-18 82.8 COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2VRXB@28216|Betaproteobacteria,477AX@75682|Oxalobacteraceae 28216|Betaproteobacteria C Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity - - - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 k59_234210_1 1128421.JAGA01000002_gene1560 2.66e-65 216.0 COG0119@1|root,COG0119@2|Bacteria,2NNVW@2323|unclassified Bacteria 2|Bacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_626415_1 1112212.JH584235_gene3723 3.15e-67 209.0 COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria,2K4NG@204457|Sphingomonadales 204457|Sphingomonadales T GAF domain-containing protein - - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF_2 k59_887258_1 1379698.RBG1_1C00001G0230 1.59e-38 146.0 COG2206@1|root,COG2206@2|Bacteria,2NPP4@2323|unclassified Bacteria 2|Bacteria T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_397672_1 1353537.TP2_02580 1.67e-45 153.0 2DC0J@1|root,2ZC8G@2|Bacteria,1RBXT@1224|Proteobacteria,2U5WY@28211|Alphaproteobacteria,2XN9C@285107|Thioclava 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_234213_1 1355374.JARU01000016_gene961 7.58e-07 52.0 COG2863@1|root,COG2863@2|Bacteria,1NBPD@1224|Proteobacteria,42VXS@68525|delta/epsilon subdivisions,2YQ9N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cytochrome - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_659606_1 765914.ThisiDRAFT_1910 1.98e-106 314.0 COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria,1WXG2@135613|Chromatiales 135613|Chromatiales V (ABC) transporter - - - - - - - - - - - - - k59_659606_2 1255043.TVNIR_3633 5.95e-15 73.6 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1WWUS@135613|Chromatiales 135613|Chromatiales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_169501_1 1198232.CYCME_0382 1.93e-123 368.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_529386_1 1168034.FH5T_14785 1.42e-31 119.0 COG1477@1|root,COG1477@2|Bacteria,4NGEK@976|Bacteroidetes,2FKZQ@200643|Bacteroidia 976|Bacteroidetes H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_529386_2 1168289.AJKI01000031_gene1049 2.89e-08 53.5 2EIGM@1|root,33C80@2|Bacteria,4NXRF@976|Bacteroidetes,2FUCC@200643|Bacteroidia,3XKDA@558415|Marinilabiliaceae 976|Bacteroidetes S COG NOG35566 non supervised orthologous group - - - - - - - - - - - - - k59_757068_1 126957.SMAR011398-PA 7.76e-06 49.3 COG2217@1|root,KOG0207@2759|Eukaryota,38BU3@33154|Opisthokonta,3BAGR@33208|Metazoa,3CT9U@33213|Bilateria,41W8Y@6656|Arthropoda 33208|Metazoa P binding. It is involved in the biological process described with metal ion transport ATP7B GO:0000041,GO:0000139,GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0000902,GO:0000904,GO:0001101,GO:0001501,GO:0001505,GO:0001568,GO:0001666,GO:0001701,GO:0001775,GO:0001836,GO:0001889,GO:0001942,GO:0001944,GO:0001974,GO:0002009,GO:0002082,GO:0002164,GO:0002252,GO:0002263,GO:0002285,GO:0002286,GO:0002287,GO:0002292,GO:0002293,GO:0002294,GO:0002366,GO:0002376,GO:0002520,GO:0002521,GO:0003674,GO:0003824,GO:0004008,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005770,GO:0005773,GO:0005774,GO:0005783,GO:0005794,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0005902,GO:0005903,GO:0005911,GO:0005923,GO:0006082,GO:0006139,GO:0006140,GO:0006163,GO:0006464,GO:0006520,GO:0006568,GO:0006570,GO:0006576,GO:0006584,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006801,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006874,GO:0006875,GO:0006878,GO:0006882,GO:0006915,GO:0006950,GO:0006955,GO:0006979,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007589,GO:0007591,GO:0007593,GO:0007595,GO:0007610,GO:0007623,GO:0007626,GO:0008047,GO:0008144,GO:0008150,GO:0008152,GO:0008219,GO:0008270,GO:0008284,GO:0008324,GO:0008361,GO:0008544,GO:0008637,GO:0009058,GO:0009059,GO:0009072,GO:0009100,GO:0009101,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009308,GO:0009628,GO:0009636,GO:0009653,GO:0009712,GO:0009713,GO:0009719,GO:0009725,GO:0009790,GO:0009791,GO:0009792,GO:0009888,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0010042,GO:0010043,GO:0010155,GO:0010243,GO:0010273,GO:0010288,GO:0010468,GO:0010591,GO:0010592,GO:0010941,GO:0010959,GO:0012501,GO:0012505,GO:0012506,GO:0014070,GO:0014074,GO:0014910,GO:0014911,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015677,GO:0015679,GO:0015680,GO:0016020,GO:0016021,GO:0016043,GO:0016323,GO:0016324,GO:0016358,GO:0016462,GO:0016530,GO:0016531,GO:0016532,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017016,GO:0017048,GO:0017076,GO:0017111,GO:0017144,GO:0018193,GO:0018205,GO:0018958,GO:0019219,GO:0019220,GO:0019222,GO:0019430,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019725,GO:0019752,GO:0019829,GO:0019899,GO:0021533,GO:0021549,GO:0021575,GO:0021587,GO:0021680,GO:0021692,GO:0021694,GO:0021695,GO:0021696,GO:0021697,GO:0021700,GO:0021702,GO:0021859,GO:0021860,GO:0021872,GO:0021879,GO:0021884,GO:0021953,GO:0021954,GO:0022008,GO:0022037,GO:0022404,GO:0022405,GO:0022607,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0022898,GO:0023052,GO:0030001,GO:0030003,GO:0030030,GO:0030054,GO:0030097,GO:0030098,GO:0030133,GO:0030135,GO:0030136,GO:0030139,GO:0030140,GO:0030141,GO:0030154,GO:0030182,GO:0030198,GO:0030199,GO:0030217,GO:0030234,GO:0030323,GO:0030324,GO:0030334,GO:0030335,GO:0030554,GO:0030659,GO:0030666,GO:0030670,GO:0030879,GO:0030900,GO:0030902,GO:0031069,GO:0031090,GO:0031175,GO:0031224,GO:0031226,GO:0031252,GO:0031253,GO:0031267,GO:0031323,GO:0031344,GO:0031346,GO:0031410,GO:0031526,GO:0031982,GO:0031984,GO:0032025,GO:0032409,GO:0032412,GO:0032501,GO:0032502,GO:0032535,GO:0032553,GO:0032555,GO:0032559,GO:0032588,GO:0032767,GO:0032879,GO:0032989,GO:0032990,GO:0033554,GO:0034220,GO:0034599,GO:0034614,GO:0034641,GO:0034645,GO:0034756,GO:0034757,GO:0034759,GO:0034760,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0035295,GO:0035434,GO:0035639,GO:0035710,GO:0036094,GO:0036119,GO:0036120,GO:0036211,GO:0036293,GO:0036294,GO:0036477,GO:0040012,GO:0040017,GO:0042093,GO:0042110,GO:0042127,GO:0042133,GO:0042221,GO:0042303,GO:0042325,GO:0042335,GO:0042414,GO:0042415,GO:0042417,GO:0042421,GO:0042423,GO:0042428,GO:0042430,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0042633,GO:0042981,GO:0042995,GO:0043005,GO:0043009,GO:0043025,GO:0043062,GO:0043066,GO:0043067,GO:0043069,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043200,GO:0043204,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043269,GO:0043271,GO:0043296,GO:0043367,GO:0043412,GO:0043434,GO:0043436,GO:0043467,GO:0043473,GO:0043492,GO:0043523,GO:0043524,GO:0043588,GO:0043682,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044093,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045121,GO:0045177,GO:0045321,GO:0045335,GO:0045793,GO:0046034,GO:0046189,GO:0046483,GO:0046631,GO:0046632,GO:0046649,GO:0046677,GO:0046683,GO:0046686,GO:0046688,GO:0046872,GO:0046873,GO:0046903,GO:0046907,GO:0046914,GO:0046915,GO:0046916,GO:0048066,GO:0048067,GO:0048085,GO:0048251,GO:0048286,GO:0048365,GO:0048468,GO:0048471,GO:0048511,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048583,GO:0048584,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048729,GO:0048730,GO:0048731,GO:0048732,GO:0048771,GO:0048812,GO:0048813,GO:0048856,GO:0048858,GO:0048869,GO:0048878,GO:0050678,GO:0050679,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050878,GO:0050896,GO:0051020,GO:0051049,GO:0051051,GO:0051087,GO:0051128,GO:0051130,GO:0051171,GO:0051174,GO:0051179,GO:0051208,GO:0051216,GO:0051234,GO:0051235,GO:0051270,GO:0051272,GO:0051341,GO:0051353,GO:0051541,GO:0051542,GO:0051591,GO:0051641,GO:0051649,GO:0051716,GO:0055065,GO:0055069,GO:0055070,GO:0055074,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0060003,GO:0060255,GO:0060322,GO:0060429,GO:0060491,GO:0060541,GO:0060548,GO:0061008,GO:0061448,GO:0061687,GO:0062012,GO:0065007,GO:0065008,GO:0065009,GO:0070160,GO:0070482,GO:0070848,GO:0070887,GO:0071229,GO:0071230,GO:0071236,GO:0071241,GO:0071248,GO:0071276,GO:0071279,GO:0071280,GO:0071281,GO:0071284,GO:0071287,GO:0071310,GO:0071363,GO:0071417,GO:0071450,GO:0071451,GO:0071453,GO:0071456,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0072358,GO:0072359,GO:0072503,GO:0072507,GO:0072521,GO:0072593,GO:0080090,GO:0080134,GO:0085029,GO:0090066,GO:0090662,GO:0097159,GO:0097164,GO:0097190,GO:0097237,GO:0097367,GO:0097435,GO:0097458,GO:0097501,GO:0097708,GO:0098588,GO:0098589,GO:0098590,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:0098772,GO:0098773,GO:0098791,GO:0098805,GO:0098857,GO:0098858,GO:0098862,GO:0098869,GO:0099131,GO:0099132,GO:0099503,GO:0120025,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:0140104,GO:1900542,GO:1901135,GO:1901137,GO:1901160,GO:1901214,GO:1901215,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901615,GO:1901617,GO:1901652,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902743,GO:1902745,GO:1903034,GO:1903036,GO:1903136,GO:1903578,GO:1904062,GO:1904063,GO:1904732,GO:1904752,GO:1904754,GO:1904959,GO:1990169,GO:1990637,GO:1990748,GO:2000145,GO:2000147 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_823173_1 1168034.FH5T_19635 2.16e-127 384.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,2FNBA@200643|Bacteroidia 976|Bacteroidetes EU Peptidase, S9A B C family, catalytic domain protein dpp - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 k59_692285_1 1124983.PFLCHA0_c08300 2.74e-12 67.4 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria,1YNYW@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria C Domain of unknown function (DUF3390) lutB - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_365574_1 572477.Alvin_2539 4.6e-51 179.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_496375_1 323848.Nmul_A0814 7.11e-118 343.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,3724H@32003|Nitrosomonadales 28216|Betaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_496375_2 1157708.KB907452_gene3835 0.000773 40.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,4ADX6@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_986347_1 404589.Anae109_2021 3.5e-40 152.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2YWBK@29|Myxococcales 28221|Deltaproteobacteria L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_3751_1 768671.ThimaDRAFT_4322 1.24e-57 185.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1WVZG@135613|Chromatiales 135613|Chromatiales T phosphate regulon transcriptional regulatory protein PhoB - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_3751_2 1125863.JAFN01000001_gene2452 4.37e-30 111.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,42W8P@68525|delta/epsilon subdivisions,2WRV4@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM NUDIX hydrolase nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_104331_1 765913.ThidrDRAFT_0510 3.69e-35 126.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1WWSM@135613|Chromatiales 135613|Chromatiales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_104331_2 582744.Msip34_1997 1.27e-45 151.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,2KMR5@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_104331_3 887062.HGR_02932 8.93e-11 62.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,4A9J9@80864|Comamonadaceae 28216|Betaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_986349_2 471854.Dfer_2124 3.5e-110 326.0 COG1879@1|root,COG1879@2|Bacteria,4NIA8@976|Bacteroidetes,47MW0@768503|Cytophagia 976|Bacteroidetes G PFAM Periplasmic binding protein LacI transcriptional regulator - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_529403_1 396588.Tgr7_0704 1.61e-68 234.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_660104_1 267377.MMP0802 4.72e-212 592.0 COG1454@1|root,arCOG00984@2157|Archaea,2XU9N@28890|Euryarchaeota,23RRM@183939|Methanococci 183939|Methanococci C Iron-containing alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_660104_2 1123288.SOV_1c03720 1.63e-49 164.0 COG4925@1|root,COG4925@2|Bacteria,1V9AI@1239|Firmicutes,4H61E@909932|Negativicutes 909932|Negativicutes S Cyclophilin-like - - - - - - - - - - - - Cyclophil_like k59_823185_1 118161.KB235922_gene1942 1.32e-58 205.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG3920@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG3920@2|Bacteria,1GIUT@1117|Cyanobacteria,3VMCY@52604|Pleurocapsales 1117|Cyanobacteria T AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF k59_104337_1 1168034.FH5T_21745 7.01e-82 263.0 COG1216@1|root,COG1216@2|Bacteria,4NFW5@976|Bacteroidetes,2FQ14@200643|Bacteroidia 976|Bacteroidetes S Glycosyltransferase, group 2 family protein wbbL - - ko:K07011 - - - - ko00000 - - - CoA_binding_3,Glyco_tranf_2_3,Glycos_transf_2 k59_692298_1 1165841.SULAR_03602 1.13e-108 328.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2YM8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.5.1 ko:K05922 - - - - ko00000,ko01000 - - - NiFeSe_Hases k59_38072_1 1168034.FH5T_13105 3.08e-99 312.0 COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes,2FPXW@200643|Bacteroidia 976|Bacteroidetes E Peptidase, S9A B C family, catalytic domain protein - - - - - - - - - - - - Peptidase_S9 k59_1019251_1 102129.Lepto7375DRAFT_1070 1.58e-47 169.0 COG5421@1|root,COG5421@2|Bacteria,1G4EU@1117|Cyanobacteria,1HA9E@1150|Oscillatoriales 1117|Cyanobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_71214_1 1116472.MGMO_29c00090 1.21e-34 136.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,1RX34@1236|Gammaproteobacteria,1XG0C@135618|Methylococcales 135618|Methylococcales T Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631,EAL,GGDEF k59_887685_2 1122134.KB893651_gene2059 1.64e-18 88.6 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1XHN1@135619|Oceanospirillales 135619|Oceanospirillales H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme - - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_7,Sirohm_synth_M,TP_methylase k59_430099_1 768671.ThimaDRAFT_2160 5e-145 415.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1WX9V@135613|Chromatiales 135613|Chromatiales E TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_953575_1 1517416.IDAT_05635 2.09e-38 143.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,2QFV4@267893|Idiomarinaceae 1236|Gammaproteobacteria U general secretion pathway protein gspF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_333217_1 469606.FSCG_00813 1.1e-63 206.0 COG0515@1|root,COG0515@2|Bacteria,379HJ@32066|Fusobacteria 32066|Fusobacteria KLT serine threonine protein kinase - - - ko:K02850 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005 - - - WaaY k59_333217_2 1319815.HMPREF0202_02179 3.79e-36 132.0 COG0859@1|root,COG0859@2|Bacteria,378J9@32066|Fusobacteria 32066|Fusobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_169988_1 1492737.FEM08_04700 1.03e-129 384.0 COG5434@1|root,COG5434@2|Bacteria,4NG4T@976|Bacteroidetes,1HZZB@117743|Flavobacteriia,2NSEJ@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_496402_1 339671.Asuc_1872 1.27e-22 92.8 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1Y7H4@135625|Pasteurellales 135625|Pasteurellales F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_496402_2 522373.Smlt3855 5.21e-98 291.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1X3QU@135614|Xanthomonadales 135614|Xanthomonadales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_660122_1 1168034.FH5T_03520 1.8e-07 51.6 COG3206@1|root,COG3206@2|Bacteria,4NSFM@976|Bacteroidetes 976|Bacteroidetes M protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - - k59_660122_2 1168034.FH5T_03515 1.28e-78 246.0 COG0162@1|root,COG0162@2|Bacteria,4NF19@976|Bacteroidetes,2FN0B@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_234692_2 1357272.AVEO02000172_gene2819 9.62e-143 418.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1Z76J@136849|Pseudomonas syringae group 1236|Gammaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound yggW GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_234692_3 1049564.TevJSym_aq00560 0.0 1046.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_234692_4 631362.Thi970DRAFT_00958 1.19e-89 280.0 COG2199@1|root,COG2199@2|Bacteria,1RDMU@1224|Proteobacteria,1RQC7@1236|Gammaproteobacteria,1X0WC@135613|Chromatiales 135613|Chromatiales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_234692_5 1216007.AOPM01000072_gene2104 2.13e-62 200.0 COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,1RQ79@1236|Gammaproteobacteria,2Q10Q@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - SLT k59_234692_6 1129794.C427_5220 1.31e-174 503.0 COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,1T44C@1236|Gammaproteobacteria,46D6Z@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_137249_1 909663.KI867150_gene334 6.88e-85 278.0 COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,42Q1P@68525|delta/epsilon subdivisions,2WM2R@28221|Deltaproteobacteria,2MRSH@213462|Syntrophobacterales 28221|Deltaproteobacteria M Peptidase M50 - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3 k59_986372_3 1128912.GMES_2078 1.03e-31 113.0 COG0346@1|root,COG0346@2|Bacteria,1RIFB@1224|Proteobacteria,1S7NP@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - - k59_724791_1 2340.JV46_16950 5.14e-135 422.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_887699_1 1005048.CFU_0420 4.53e-31 114.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2VRAK@28216|Betaproteobacteria,474BD@75682|Oxalobacteraceae 28216|Betaproteobacteria J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_887699_2 1260251.SPISAL_07385 3.87e-14 67.0 COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,1WZ8N@135613|Chromatiales 135613|Chromatiales J Ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_887699_3 1122604.JONR01000006_gene2673 9.19e-32 115.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,1X5KF@135614|Xanthomonadales 135614|Xanthomonadales J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_568640_1 391615.ABSJ01000030_gene811 1.8e-45 162.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,1J551@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Amine oxidase flavin-containing - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_7984_1 1168034.FH5T_04170 3.6e-121 381.0 COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,2FMWR@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_698944_1 572544.Ilyop_1614 7.62e-158 466.0 COG0855@1|root,COG0855@2|Bacteria,379PC@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_698944_2 1396418.BATQ01000054_gene8 1.1e-135 414.0 2DBRE@1|root,2ZAK7@2|Bacteria,46TZ4@74201|Verrucomicrobia,2ITNY@203494|Verrucomicrobiae 203494|Verrucomicrobiae - - - - - - - - - - - - - - - k59_698944_3 869209.Tresu_2413 1.34e-10 71.6 COG0248@1|root,COG0248@2|Bacteria,2J5XU@203691|Spirochaetes 203691|Spirochaetes FP Ppx GppA phosphatase family - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA k59_829662_1 929556.Solca_1617 3.84e-17 84.7 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1IP3T@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family bga GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_601498_1 2340.JV46_10460 3.3e-39 132.0 COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,1S9CV@1236|Gammaproteobacteria 1236|Gammaproteobacteria P nitrite reductase nirD - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske,Rieske_2 k59_601498_2 1163617.SCD_n02266 6.84e-50 175.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_536442_1 926692.AZYG01000092_gene1703 2.7e-28 114.0 COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,3WB49@53433|Halanaerobiales 186801|Clostridia H PFAM MoeA domain protein domain I and II moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_794194_1 1123326.JFBL01000001_gene1222 2.31e-101 301.0 COG3842@1|root,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,42MSG@68525|delta/epsilon subdivisions,2YMX7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E ATP-binding protein modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran k59_794194_2 1165841.SULAR_00670 1.52e-17 79.3 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,42NZV@68525|delta/epsilon subdivisions,2YN88@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter permease modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_43605_1 319225.Plut_0379 1.2e-28 120.0 COG2911@1|root,COG2931@1|root,COG3386@1|root,COG4932@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3386@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein espK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K07004,ko:K14274,ko:K18491 ko00040,ko04550,map00040,map04550 - R02427 RC00713 ko00000,ko00001,ko01000,ko03000 - - - CarboxypepD_reg,FG-GAP,HemolysinCabind,SGL k59_829671_1 1049564.TevJSym_ac02050 4.93e-57 196.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1J4QZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_43608_1 643867.Ftrac_2457 7.85e-45 152.0 COG0664@1|root,COG0664@2|Bacteria,4NG87@976|Bacteroidetes,47R6M@768503|Cytophagia 976|Bacteroidetes T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_960280_1 1384056.N787_02780 2.77e-66 227.0 COG0591@1|root,COG0642@1|root,COG0745@1|root,COG0591@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_305859_1 477974.Daud_0093 1.42e-41 150.0 COG0247@1|root,COG0247@2|Bacteria,1UZQ0@1239|Firmicutes,24E5H@186801|Clostridia,2672H@186807|Peptococcaceae 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17 k59_469853_3 1149133.ppKF707_0104 1.13e-62 199.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1YDPQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Phosphoribosyl transferase domain hpt GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_469853_4 765913.ThidrDRAFT_2066 4.62e-144 418.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales 135613|Chromatiales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_469853_5 1049564.TevJSym_ah00540 2.11e-31 115.0 COG1580@1|root,COG1580@2|Bacteria,1ND67@1224|Proteobacteria,1SDZM@1236|Gammaproteobacteria,1J7DH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Controls the rotational direction of flagella during chemotaxis - - - ko:K02415 - - - - ko00000,ko02035 - - - FliL k59_469853_6 765912.Thimo_2071 2.21e-117 343.0 COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,1WW83@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_469853_7 1249627.D779_2615 8.78e-135 392.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WW7F@135613|Chromatiales 135613|Chromatiales EP PFAM Binding-protein-dependent transport - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_469853_8 765912.Thimo_2069 1.85e-71 220.0 COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,1S6DY@1236|Gammaproteobacteria,1X25T@135613|Chromatiales 135613|Chromatiales S PFAM ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD k59_469853_9 105559.Nwat_1217 1.63e-198 568.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales 135613|Chromatiales E PFAM Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_469853_10 765912.Thimo_1696 5.17e-59 187.0 COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1WYAI@135613|Chromatiales 135613|Chromatiales S PFAM Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_469853_11 1049564.TevJSym_ah00480 3.74e-210 593.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1J5T0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rlmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070041,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_469853_12 1049564.TevJSym_ah00440 8.84e-166 469.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1J502@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysM GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2444 PALP k59_469853_13 1123392.AQWL01000018_gene72 3.63e-98 323.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2VH4X@28216|Betaproteobacteria 28216|Betaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_469853_14 640081.Dsui_2895 3.43e-40 151.0 COG2984@1|root,COG2984@2|Bacteria,1NACH@1224|Proteobacteria,2VSU8@28216|Betaproteobacteria,2KWT6@206389|Rhodocyclales 206389|Rhodocyclales S transport system, periplasmic component - - - - - - - - - - - - ABC_sub_bind k59_469853_15 1149133.ppKF707_0796 2.19e-128 417.0 COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1YF47@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Uncharacterised signal transduction histidine kinase domain (DUF2222) barA GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_469853_16 1026882.MAMP_00294 1.02e-157 457.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII - - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - DUF4113,IMS,IMS_C k59_469853_17 2340.JV46_13280 2.88e-58 184.0 2E1WQ@1|root,32X5W@2|Bacteria,1N2F8@1224|Proteobacteria,1SA2N@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_469853_19 384765.SIAM614_04360 2.24e-103 315.0 COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,2TR3K@28211|Alphaproteobacteria 28211|Alphaproteobacteria M murein endopeptidase mepA - - ko:K07261 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M74 k59_469853_20 396588.Tgr7_2202 2.7e-145 428.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1WXF3@135613|Chromatiales 135613|Chromatiales I Membrane protein involved in aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_469853_21 2340.JV46_26950 6.85e-36 141.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1J4VQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T a CheY-like receiver domain and an HD-GYP domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_469853_22 351348.Maqu_2697 2.3e-126 375.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,464WH@72275|Alteromonadaceae 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_469853_23 1049564.TevJSym_ab00700 1.97e-145 415.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1J4V7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease/Exonuclease/phosphatase family xthA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008853,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_469853_24 32042.PstZobell_03525 1.23e-104 311.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RMVZ@1236|Gammaproteobacteria,1Z1IT@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Fe-S oxidoreductase lutA - - ko:K18928 - - - - ko00000 - - - CCG k59_469853_25 870187.Thini_2168 9.41e-220 620.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Iron-sulfur cluster binding protein lutB - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_469853_26 870187.Thini_2167 2.68e-58 191.0 COG1556@1|root,COG1556@2|Bacteria,1RJ6A@1224|Proteobacteria,1S7WZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LUD domain ykgG - - ko:K00782 - - - - ko00000 - - iECO111_1330.ECO111_0342,iECO26_1355.ECO26_0342 LUD_dom k59_469853_27 765913.ThidrDRAFT_2221 5.83e-98 288.0 COG0346@1|root,COG0346@2|Bacteria,1RIBY@1224|Proteobacteria,1SHBE@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_469853_28 330214.NIDE3653 2.92e-36 127.0 COG3631@1|root,COG3631@2|Bacteria 2|Bacteria S light absorption - - - - - - - - - - - - NTF2,SnoaL_2 k59_469853_29 1188252.AJYK01000057_gene297 1.97e-90 268.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1S6G7@1236|Gammaproteobacteria,1XV3H@135623|Vibrionales 135623|Vibrionales S membrane - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_469853_30 498211.CJA_1891 2.16e-39 134.0 COG0695@1|root,COG0695@2|Bacteria,1N6ZT@1224|Proteobacteria,1SD1U@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Glutaredoxin nrdH - - - - - - - - - - - Glutaredoxin k59_469853_31 177439.DP2485 1.54e-41 138.0 COG2350@1|root,COG2350@2|Bacteria,1N8AZ@1224|Proteobacteria,42V5N@68525|delta/epsilon subdivisions,2WWPC@28221|Deltaproteobacteria 28221|Deltaproteobacteria S YCII-related domain - - - - - - - - - - - - YCII k59_469853_32 1227487.C474_12461 3.6e-213 618.0 COG0296@1|root,arCOG02951@2157|Archaea,2Y0XG@28890|Euryarchaeota,23ZEB@183963|Halobacteria 183963|Halobacteria G Alpha amylase, catalytic domain - - - - - - - - - - - - Alpha-amylase k59_469853_33 1291050.JAGE01000001_gene415 1.18e-104 313.0 COG0330@1|root,COG0330@2|Bacteria,1TRN5@1239|Firmicutes,248UU@186801|Clostridia,3WI4C@541000|Ruminococcaceae 186801|Clostridia O SPFH Band 7 PHB domain protein - - - - - - - - - - - - Band_7 k59_469853_34 1249627.D779_0984 5.05e-41 140.0 COG1765@1|root,COG1765@2|Bacteria,1QMYJ@1224|Proteobacteria,1TKA0@1236|Gammaproteobacteria,1X0YP@135613|Chromatiales 135613|Chromatiales O OsmC-like protein - - - - - - - - - - - - OsmC k59_469853_35 1430440.MGMSRv2_3601 2.43e-211 598.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2JQ3A@204441|Rhodospirillales 204441|Rhodospirillales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpd - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_469853_36 856793.MICA_658 4.53e-155 451.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,4BPQ0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_469853_37 1123355.JHYO01000015_gene1997 0.0 1284.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,36XIW@31993|Methylocystaceae 28211|Alphaproteobacteria C 2-oxoglutarate dehydrogenase C-terminal sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_469853_38 1057002.KB905370_gene2354 1.47e-16 85.1 COG0810@1|root,COG0810@2|Bacteria,1RESZ@1224|Proteobacteria,2UAM6@28211|Alphaproteobacteria,4BMTN@82115|Rhizobiaceae 28211|Alphaproteobacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_469853_39 634452.APA01_04240 1.37e-38 144.0 COG0614@1|root,COG0614@2|Bacteria,1RAUP@1224|Proteobacteria,2TUB0@28211|Alphaproteobacteria,2JSZ7@204441|Rhodospirillales 204441|Rhodospirillales P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_469853_40 1049564.TevJSym_bj00200 2.83e-123 364.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1J9PB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily btuC - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_469853_41 572477.Alvin_1825 1.81e-68 219.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,1RQ6C@1236|Gammaproteobacteria,1WVWI@135613|Chromatiales 135613|Chromatiales HP pfam abc - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_469853_42 1209072.ALBT01000052_gene652 5.38e-127 397.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1FHSU@10|Cellvibrio 1236|Gammaproteobacteria H TonB dependent receptor - - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec k59_469853_43 1049564.TevJSym_ad01520 3.08e-198 573.0 COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,1RNYP@1236|Gammaproteobacteria,1J59Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T response regulator - - - ko:K20977 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko02022 - - - HATPase_c_2,Response_reg,SpoIIE k59_469853_44 306281.AJLK01000118_gene4085 3.08e-69 226.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - - - - - - - - - - GGDEF,Response_reg k59_469853_45 2340.JV46_25240 8.69e-90 269.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RXB4@1236|Gammaproteobacteria,1JAMN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - - - - - - - - - - - LexA_DNA_bind,Peptidase_S24 k59_469853_47 1283300.ATXB01000001_gene1602 3.32e-141 416.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XDNC@135618|Methylococcales 135618|Methylococcales EH synthase component I pabB - 2.6.1.85 ko:K01665 ko00790,map00790 - R01716 RC00010,RC01418 ko00000,ko00001,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_469853_48 1049564.TevJSym_ad01500 3.8e-55 173.0 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1J6GT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himD GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2001141 - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_469853_49 1049564.TevJSym_ad01490 0.0 913.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1J51F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113,GO:2000765,GO:2000766 - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_469853_50 1122951.ATUE01000006_gene1243 2.71e-70 221.0 COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,3NKW2@468|Moraxellaceae 1236|Gammaproteobacteria F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1391,iSDY_1059.SDY_2348 Cytidylate_kin k59_469853_51 519989.ECTPHS_08261 2.29e-215 606.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1WX54@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_469853_52 2340.JV46_02780 8.74e-142 408.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1J5SK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Prephenate dehydrogenase tyrC - 1.3.1.12 ko:K00210,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_469853_53 1049564.TevJSym_ad01440 3.94e-189 534.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1J5KH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_469853_54 2340.JV46_02800 1.19e-149 433.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1J4I4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_469853_55 1049564.TevJSym_ad01420 3.97e-216 604.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1J5JA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_469853_56 2340.JV46_02820 3.66e-201 563.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1J4PA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935 Aminotran_5 k59_469853_57 2340.JV46_02830 0.0 1146.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1J52I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_829681_1 1168034.FH5T_07080 5.65e-36 134.0 COG1523@1|root,COG1523@2|Bacteria,4NIH2@976|Bacteroidetes,2FKZS@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 13 family pulA - 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 - R02111 - ko00000,ko00001,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_829681_2 1168034.FH5T_07085 1.77e-47 156.0 28UTG@1|root,2ZGXN@2|Bacteria,4P80G@976|Bacteroidetes,2FZFM@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_601519_1 768671.ThimaDRAFT_2338 2.63e-136 395.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1WXHI@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_272690_1 768671.ThimaDRAFT_3411 2.3e-06 50.4 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales 135613|Chromatiales O TIGRFAM Cytochrome c-type biogenesis protein CcmI - - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_272690_2 301.JNHE01000007_gene1312 1.46e-32 119.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria 1236|Gammaproteobacteria P subunit of a heme lyase ccmH GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567 - ko:K02200 - - - - ko00000 - - - CcmH k59_794203_1 870187.Thini_0095 4.14e-108 335.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4601N@72273|Thiotrichales 72273|Thiotrichales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_568683_1 1168034.FH5T_10435 7.99e-102 306.0 COG0826@1|root,COG0826@2|Bacteria,4NERN@976|Bacteroidetes,2FN1E@200643|Bacteroidia 976|Bacteroidetes O Peptidase, U32 family prtC - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_730744_1 929558.SMGD1_1549 1.09e-08 62.0 COG4773@1|root,COG4773@2|Bacteria,1PP2I@1224|Proteobacteria,42WFP@68525|delta/epsilon subdivisions,2YQM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD k59_272694_2 1123401.JHYQ01000013_gene690 2.97e-41 144.0 COG3658@1|root,COG3658@2|Bacteria,1PS0D@1224|Proteobacteria,1SJEU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_602606_1 1366050.N234_25070 1.48e-22 97.8 COG2186@1|root,COG2186@2|Bacteria,1R68P@1224|Proteobacteria,2VK2A@28216|Betaproteobacteria 1224|Proteobacteria K Regulatory protein GntR HTH - - - - - - - - - - - - FCD,GntR k59_830648_1 1232410.KI421425_gene1552 1.4e-85 282.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_505277_1 1249627.D779_3523 1.71e-85 272.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales 135613|Chromatiales M Surface antigen variable number - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_8646_1 572480.Arnit_1512 6.95e-22 98.6 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,42MCZ@68525|delta/epsilon subdivisions,2YNNG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M type I secretion membrane fusion protein, HlyD family - - - ko:K02022,ko:K12542 - M00330 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1 - - Biotin_lipoyl_2,HlyD_3 k59_341767_1 1122604.JONR01000001_gene1829 2.65e-27 105.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1X34H@135614|Xanthomonadales 135614|Xanthomonadales E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_341767_2 930166.CD58_06040 1.83e-63 219.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_405483_1 1168034.FH5T_14635 2.03e-45 156.0 COG1609@1|root,COG1609@2|Bacteria,4NKD4@976|Bacteroidetes,2FP0W@200643|Bacteroidia 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - GntR,Peripla_BP_3 k59_405483_2 1168034.FH5T_14630 1.11e-28 113.0 COG1070@1|root,COG1070@2|Bacteria,4NFBZ@976|Bacteroidetes,2FPIS@200643|Bacteroidia 976|Bacteroidetes G Carbohydrate kinase, FGGY family protein xylB_2 - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_896340_1 1358423.N180_03430 0.000122 50.1 COG4219@1|root,COG4219@2|Bacteria,4NDWS@976|Bacteroidetes 976|Bacteroidetes KT Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - CarbopepD_reg_2,Peptidase_M56,Plug,TonB_C k59_470717_1 880071.Fleli_2325 2.55e-11 69.7 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,4NKPG@976|Bacteroidetes,47TCB@768503|Cytophagia 976|Bacteroidetes L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_29,HTH_33 k59_1026203_1 243164.DET1330 4.93e-07 50.4 COG0454@1|root,COG0456@2|Bacteria,2GATN@200795|Chloroflexi,34DBC@301297|Dehalococcoidia 301297|Dehalococcoidia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_1026203_2 525904.Tter_1676 5.49e-31 114.0 COG1225@1|root,COG1225@2|Bacteria,2NPEE@2323|unclassified Bacteria 2|Bacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bcp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_341768_1 2002.JOEQ01000003_gene2513 6.92e-32 125.0 COG3211@1|root,COG3211@2|Bacteria,2GJ6J@201174|Actinobacteria 201174|Actinobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_306909_1 1291050.JAGE01000001_gene850 6.01e-07 57.0 COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,3WIYH@541000|Ruminococcaceae 186801|Clostridia ET Belongs to the bacterial solute-binding protein 3 family artP - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_207520_1 742767.HMPREF9456_00057 1.5e-27 108.0 COG1040@1|root,COG1040@2|Bacteria,4NNI1@976|Bacteroidetes,2FP14@200643|Bacteroidia,22XYS@171551|Porphyromonadaceae 976|Bacteroidetes S Phosphoribosyl transferase domain comF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - Pribosyltran k59_42199_1 1168034.FH5T_11105 8.14e-61 199.0 COG2304@1|root,COG2304@2|Bacteria,4NKZ6@976|Bacteroidetes,2FVGE@200643|Bacteroidia 976|Bacteroidetes S CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2 k59_402894_1 1348657.M622_05550 9.21e-90 282.0 COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,2WHHS@28216|Betaproteobacteria 28216|Betaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger,TrkA_N k59_402895_1 879212.DespoDRAFT_00038 7.92e-19 83.2 2C5J8@1|root,30F9Z@2|Bacteria,1RE16@1224|Proteobacteria,42RYB@68525|delta/epsilon subdivisions,2WNIF@28221|Deltaproteobacteria,2MJSR@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_402895_2 643562.Daes_1006 6.33e-56 186.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42MRE@68525|delta/epsilon subdivisions,2WIP0@28221|Deltaproteobacteria,2M81I@213115|Desulfovibrionales 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_926891_1 572544.Ilyop_1259 1.61e-136 417.0 COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,3784B@32066|Fusobacteria 32066|Fusobacteria H tRNA nucleotidyltransferase poly(A) polymerase - - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,NUDIX,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 k59_142842_1 1051646.VITU9109_25300 6.75e-46 152.0 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XXFK@135623|Vibrionales 135623|Vibrionales T COG0517 FOG CBS domain - - - - - - - - - - - - CBS k59_142842_2 935567.JAES01000012_gene955 4.71e-48 160.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1S6G7@1236|Gammaproteobacteria,1X6FR@135614|Xanthomonadales 135614|Xanthomonadales S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_76683_1 563040.Saut_0916 1.16e-32 127.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2YMAI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_76683_2 326298.Suden_0871 2e-108 325.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2YMG2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_304130_1 526218.Sterm_1020 3.82e-87 270.0 COG0079@1|root,COG0079@2|Bacteria,378HR@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_304130_2 526218.Sterm_1021 4.58e-126 371.0 COG0373@1|root,COG0373@2|Bacteria,378K5@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,Shikimate_DH k59_534925_1 638303.Thal_0354 2.76e-11 63.5 COG0527@1|root,COG0527@2|Bacteria,2G3JF@200783|Aquificae 200783|Aquificae E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_534925_2 394503.Ccel_1144 3.55e-06 49.7 COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae 186801|Clostridia P Belongs to the sulfur carrier protein TusA family cdr - - - - - - - - - - - DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA k59_534928_1 1249627.D779_0518 5.64e-54 174.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1WX5I@135613|Chromatiales 135613|Chromatiales J Belongs to the SUA5 family - - - - - - - - - - - - Sua5_yciO_yrdC k59_534928_2 768671.ThimaDRAFT_2027 1.44e-21 91.7 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria,1WXKB@135613|Chromatiales 135613|Chromatiales S pfam php - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_239756_1 1168034.FH5T_22135 1.12e-66 215.0 COG0860@1|root,COG0860@2|Bacteria,4NGKC@976|Bacteroidetes,2FPGX@200643|Bacteroidia 976|Bacteroidetes M N-acetylmuramoyl-L-alanine amidase amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_893384_1 269797.Mbar_A2789 6.49e-17 81.3 arCOG04931@1|root,arCOG04931@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - DDE_Tnp_IS240 k59_175059_2 631362.Thi970DRAFT_03594 7.33e-16 71.2 COG3242@1|root,COG3242@2|Bacteria,1PU4H@1224|Proteobacteria,1RWCT@1236|Gammaproteobacteria,1WZPF@135613|Chromatiales 135613|Chromatiales S protein conserved in bacteria - - - ko:K09937 - - - - ko00000 - - - DUF2065 k59_468740_2 743974.MBO_09183 7.2e-30 114.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,3NJTJ@468|Moraxellaceae 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009333,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2414,iAPECO1_1312.APECO1_4131,iB21_1397.B21_02275,iBWG_1329.BWG_2176,iE2348C_1286.E2348C_2600,iEC042_1314.EC042_2623,iEC55989_1330.EC55989_2704,iECABU_c1320.ECABU_c27350,iECBD_1354.ECBD_1267,iECB_1328.ECB_02314,iECDH10B_1368.ECDH10B_2579,iECDH1ME8569_1439.ECDH1ME8569_2348,iECD_1391.ECD_02314,iECED1_1282.ECED1_2858,iECH74115_1262.ECH74115_3645,iECIAI1_1343.ECIAI1_2472,iECNA114_1301.ECNA114_2491,iECO103_1326.ECO103_2933,iECO111_1330.ECO111_3144,iECO26_1355.ECO26_3467,iECOK1_1307.ECOK1_2731,iECP_1309.ECP_2438,iECS88_1305.ECS88_2604,iECSE_1348.ECSE_2705,iECSF_1327.ECSF_2278,iECSP_1301.ECSP_3362,iECUMN_1333.ECUMN_2736,iECW_1372.ECW_m2643,iECs_1301.ECs3286,iEKO11_1354.EKO11_1314,iETEC_1333.ETEC_2527,iEcDH1_1363.EcDH1_1247,iEcHS_1320.EcHS_A2549,iEcSMS35_1347.EcSMS35_2569,iEcolC_1368.EcolC_1264,iG2583_1286.G2583_2946,iJO1366.b2414,iJR904.b2414,iLF82_1304.LF82_0418,iNRG857_1313.NRG857_12105,iSSON_1240.SSON_2503,iSbBS512_1146.SbBS512_E2766,iUMN146_1321.UM146_04550,iUMNK88_1353.UMNK88_3016,iUTI89_1310.UTI89_C2747,iWFL_1372.ECW_m2643,iY75_1357.Y75_RS12650,iZ_1308.Z3680 PALP k59_271458_1 1033802.SSPSH_000721 2.6e-47 162.0 COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,1SEZZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF374) - - - ko:K09778 - - - - ko00000 - - - DUF374 k59_435091_1 1122603.ATVI01000005_gene3501 1.84e-18 89.7 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales 1236|Gammaproteobacteria T Tetratricopeptide repeat - - - - - - - - - - - - Guanylate_cyc,TPR_19,TPR_2,TPR_8 k59_697332_1 1305737.JAFX01000001_gene1812 2.33e-62 213.0 2CHVP@1|root,2Z866@2|Bacteria,4NJWZ@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_958527_1 1123253.AUBD01000005_gene6 1.95e-51 171.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1X4AQ@135614|Xanthomonadales 135614|Xanthomonadales M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_893393_1 1168034.FH5T_14410 1.94e-64 208.0 COG0621@1|root,COG0621@2|Bacteria,4NZXZ@976|Bacteroidetes,2FX31@200643|Bacteroidia 976|Bacteroidetes J TRAM domain - - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_109545_1 72664.XP_006404493.1 3.21e-52 166.0 COG0838@1|root,KOG4662@2759|Eukaryota,37UN0@33090|Viridiplantae,3GISB@35493|Streptophyta 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008137,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0015979,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K05574 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_q4 k59_142865_1 4113.PGSC0003DMT400045546 2.31e-214 599.0 COG0086@1|root,2QPYA@2759|Eukaryota,37HSD@33090|Viridiplantae,3GDVE@35493|Streptophyta,44T9G@71274|asterids 35493|Streptophyta K RNA polymerase rpoC2 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - - k59_239776_1 1122605.KB893645_gene962 7.21e-85 276.0 COG3250@1|root,COG3250@2|Bacteria,4NF4T@976|Bacteroidetes,1IRFA@117747|Sphingobacteriia 976|Bacteroidetes G Glycoside hydrolase family 2 TIM barrel - - - - - - - - - - - - Bgal_small_N,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_729197_1 706587.Desti_5357 6.01e-97 296.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C methylmalonate-semialdehyde dehydrogenase mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_860347_1 655815.ZPR_0151 1.9e-20 84.7 COG2827@1|root,COG2827@2|Bacteria,4NW73@976|Bacteroidetes,1I5Z9@117743|Flavobacteriia 976|Bacteroidetes L GIY-YIG catalytic domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_860347_2 929713.NIASO_12660 7.34e-24 100.0 COG3669@1|root,COG3669@2|Bacteria,4NEDX@976|Bacteroidetes,1IQ6C@117747|Sphingobacteriia 976|Bacteroidetes G PFAM coagulation factor 5 8 type - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,CHB_HEX_C_1,F5_F8_type_C k59_435101_1 1121434.AULY01000006_gene441 1e-51 178.0 COG1740@1|root,COG1740@2|Bacteria,1PW7V@1224|Proteobacteria,43B3H@68525|delta/epsilon subdivisions,2X6HA@28221|Deltaproteobacteria,2M9TA@213115|Desulfovibrionales 28221|Deltaproteobacteria C small subunit hysB - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_992680_2 1532557.JL37_14890 1.18e-27 108.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,3T1K5@506|Alcaligenaceae 28216|Betaproteobacteria S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_143506_2 555778.Hneap_0228 5.05e-48 165.0 COG0561@1|root,COG0561@2|Bacteria,1QDJR@1224|Proteobacteria,1RSEI@1236|Gammaproteobacteria,1WX4S@135613|Chromatiales 135613|Chromatiales S HAD-superfamily hydrolase, subfamily IIB - - - - - - - - - - - - S6PP,YcgL k59_175773_1 768671.ThimaDRAFT_1403 3.32e-101 310.0 COG1109@1|root,COG1109@2|Bacteria,1MUB3@1224|Proteobacteria,1RNFZ@1236|Gammaproteobacteria,1WVYP@135613|Chromatiales 135613|Chromatiales G alpha beta alpha domain I - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_567794_1 879212.DespoDRAFT_00665 8.45e-154 440.0 COG3385@1|root,COG3385@2|Bacteria,1REZ3@1224|Proteobacteria,42RPA@68525|delta/epsilon subdivisions,2WNFF@28221|Deltaproteobacteria,2MPI9@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_240277_1 1232410.KI421425_gene1552 2.5e-86 286.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_403523_1 768671.ThimaDRAFT_0869 1.05e-76 241.0 COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,1S8EQ@1236|Gammaproteobacteria,1WYKW@135613|Chromatiales 135613|Chromatiales Q MlaD protein - - - ko:K06192 - - - - ko00000 - - - MlaD k59_894102_1 1168034.FH5T_22115 5.29e-60 202.0 COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,2FNIQ@200643|Bacteroidia 976|Bacteroidetes L COG COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_339693_2 1150621.SMUL_1274 6.02e-60 189.0 2CIQB@1|root,30R27@2|Bacteria,1N4EG@1224|Proteobacteria,431EN@68525|delta/epsilon subdivisions 1224|Proteobacteria S MTH538 TIR-like domain (DUF1863) - - - - - - - - - - - - DUF1863 k59_793586_1 1537917.JU82_11505 1.03e-94 283.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2YMFH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_271830_1 237368.SCABRO_01185 2.69e-35 138.0 COG1629@1|root,COG4771@2|Bacteria,2J47W@203682|Planctomycetes 203682|Planctomycetes P TonB dependent receptor - - - - - - - - - - - - TonB_dep_Rec k59_567798_1 1288494.EBAPG3_170 4.48e-32 115.0 2DNU1@1|root,32Z4S@2|Bacteria,1N8FB@1224|Proteobacteria,2WG7W@28216|Betaproteobacteria 28216|Betaproteobacteria S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like k59_567798_2 1123279.ATUS01000002_gene86 1.36e-49 161.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,1J66X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1186 Protein chain release factor B yaeJ GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_175776_1 1122179.KB890469_gene599 1.49e-127 404.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_469331_1 543632.JOJL01000012_gene6668 1.42e-23 105.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4DI3B@85008|Micromonosporales 201174|Actinobacteria J Amidase - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_42767_1 929558.SMGD1_2153 8.13e-131 379.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2YMK8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_600488_1 1121405.dsmv_1857 1.93e-36 134.0 28VGR@1|root,2ZHJ8@2|Bacteria,1RBS0@1224|Proteobacteria,42QZB@68525|delta/epsilon subdivisions,2WN03@28221|Deltaproteobacteria,2MJPZ@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_633130_1 1449048.JQKU01000008_gene929 3.13e-35 127.0 COG2020@1|root,COG2020@2|Bacteria,2GN9N@201174|Actinobacteria,2336J@1762|Mycobacteriaceae 201174|Actinobacteria O NnrU protein - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU k59_697994_2 71421.HI_0101 9.74e-14 68.6 COG1876@1|root,COG1876@2|Bacteria,1N2IC@1224|Proteobacteria,1S0DU@1236|Gammaproteobacteria,1Y78F@135625|Pasteurellales 135625|Pasteurellales M D-alanyl-D-alanine carboxypeptidase Z012_10490 - - - - - - - - - - - VanY k59_600492_1 1225785.CM001983_gene2687 4.39e-07 56.6 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,2JDHT@204037|Dickeya 1236|Gammaproteobacteria M PFAM Lytic transglycosylase catalytic mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_762925_1 387093.SUN_1893 3.95e-121 355.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2YMQJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_208319_1 1415778.JQMM01000001_gene286 2.14e-18 87.8 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane lipoprotein-sorting protein VPA0557 - - - - - - - - - - - LolA_like k59_567808_1 1121937.AUHJ01000004_gene1129 9.03e-26 104.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,463ZN@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_567808_2 1116472.MGMO_141c00070 9.89e-43 149.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,1RQKK@1236|Gammaproteobacteria,1XE0S@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_371556_2 1441930.Z042_11535 2.21e-46 152.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,400B1@613|Serratia 1236|Gammaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_959247_1 1121904.ARBP01000001_gene5469 9.03e-134 410.0 COG4206@1|root,COG4206@2|Bacteria,4NZWU@976|Bacteroidetes,47JVR@768503|Cytophagia 976|Bacteroidetes H TIGRFAM TonB-dependent outer membrane receptor, SusC RagA subfamily, signature region - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_143550_1 395494.Galf_1867 2.62e-47 170.0 COG3179@1|root,COG3179@2|Bacteria 2|Bacteria Q chitinase - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - Glyco_hydro_16,Glyco_hydro_19,Glyco_hydro_64,RicinB_lectin_2,Ricin_B_lectin,Thaumatin k59_304829_2 911239.CF149_18336 1.26e-25 104.0 COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis signal transduction protein pilI - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_304829_3 1121035.AUCH01000003_gene1375 7.04e-08 51.2 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,2KWTI@206389|Rhodocyclales 206389|Rhodocyclales T response regulator receiver pilH - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_240317_1 396588.Tgr7_1387 5.87e-48 170.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1X0DP@135613|Chromatiales 135613|Chromatiales G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_633162_1 1168034.FH5T_12600 3.79e-82 260.0 COG3266@1|root,COG3266@2|Bacteria,4NH1U@976|Bacteroidetes,2FUGU@200643|Bacteroidia 976|Bacteroidetes S domain, Protein - - - - - - - - - - - - OMP_b-brl_2 k59_175819_1 1122915.AUGY01000118_gene6533 9.79e-68 219.0 COG0715@1|root,COG0715@2|Bacteria,1VRJ0@1239|Firmicutes,4HV8W@91061|Bacilli,26U3V@186822|Paenibacillaceae 91061|Bacilli P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - - - - - - - - - - - k59_110139_1 522306.CAP2UW1_1167 1.32e-43 147.0 2D3GG@1|root,32TEX@2|Bacteria,1N6JV@1224|Proteobacteria,2W2MW@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_371582_1 95619.PM1_0204890 5.26e-63 204.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Lytic murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_762954_1 1158292.JPOE01000005_gene1145 1.7e-133 391.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1KKER@119065|unclassified Burkholderiales 28216|Betaproteobacteria G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp2 - 3.1.3.11,3.1.3.37 ko:K01086,ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_762954_2 522306.CAP2UW1_0958 2.31e-158 449.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,2VHZD@28216|Betaproteobacteria 28216|Betaproteobacteria C Phosphoribulokinase cbbP - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_762954_3 443152.MDG893_16122 9.1e-23 97.1 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,46A3P@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG1233 Phytoene dehydrogenase and related proteins - - 1.3.99.23 ko:K09516 ko00830,map00830 - R07163 RC01835 ko00000,ko00001,ko01000 - - - Amino_oxidase,FAD_binding_6,NAD_binding_1,NAD_binding_8 k59_567835_1 998674.ATTE01000001_gene2580 2.93e-94 302.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,45ZYT@72273|Thiotrichales 72273|Thiotrichales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_600533_1 439235.Dalk_0205 3.2e-14 77.4 28RRT@1|root,33K0J@2|Bacteria,1NKEP@1224|Proteobacteria,430T6@68525|delta/epsilon subdivisions,2WW1A@28221|Deltaproteobacteria,2MNQS@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF3187) - - - - - - - - - - - - DUF3187 k59_77341_1 1121405.dsmv_2074 8.99e-81 261.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2MIHW@213118|Desulfobacterales 28221|Deltaproteobacteria O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_110142_1 491952.Mar181_2035 1.01e-10 70.1 COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - CBM_2,HCBP_related,HemolysinCabind k59_861057_1 1004149.AFOE01000052_gene256 1.37e-29 112.0 COG0412@1|root,COG0412@2|Bacteria,4NEUX@976|Bacteroidetes,1HXBT@117743|Flavobacteriia 976|Bacteroidetes Q dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_861057_2 886379.AEWI01000028_gene238 1.05e-126 379.0 COG2730@1|root,COG3509@1|root,COG2730@2|Bacteria,COG3509@2|Bacteria,4NHQ1@976|Bacteroidetes,2FQ5R@200643|Bacteroidia,3XJ0N@558415|Marinilabiliaceae 976|Bacteroidetes G Cellulase (glycosyl hydrolase family 5) - - - - - - - - - - - - CBM_4_9,Cellulase k59_997566_1 987059.RBXJA2T_11628 3.29e-79 246.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,1KJGU@119065|unclassified Burkholderiales 28216|Betaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_213350_1 391625.PPSIR1_23274 4.25e-33 131.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2WIWF@28221|Deltaproteobacteria,2YUMB@29|Myxococcales 28221|Deltaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_244995_1 563040.Saut_1882 1.9e-144 420.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2YN3A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E 8-amino-7-oxononanoate synthase bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_47700_2 1231057.AMGD01000047_gene580 7.33e-06 48.9 COG1876@1|root,COG3807@1|root,COG1876@2|Bacteria,COG3807@2|Bacteria,1V1F7@1239|Firmicutes,4HBR1@91061|Bacilli,26DQX@186818|Planococcaceae 91061|Bacilli M D-alanyl-D-alanine carboxypeptidase vanYB - 3.4.17.14 ko:K07260 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - SH3_3,VanY k59_345172_1 160488.PP_4927 1.11e-67 226.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain hlyB - - ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_345175_1 1123261.AXDW01000003_gene1849 0.000512 48.1 COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1X4JW@135614|Xanthomonadales 135614|Xanthomonadales M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_703497_1 519989.ECTPHS_04955 1.76e-82 263.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1WXRD@135613|Chromatiales 135613|Chromatiales O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD k59_474066_1 1122927.KB895414_gene5126 4.14e-59 194.0 COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,26QXS@186822|Paenibacillaceae 91061|Bacilli C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - - - - - - - - - - ADH_N,ADH_zinc_N_2 k59_638539_1 765913.ThidrDRAFT_0119 6.44e-39 136.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1WY3H@135613|Chromatiales 135613|Chromatiales L Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_638539_2 1125863.JAFN01000001_gene2170 1.59e-06 49.3 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_998098_1 768671.ThimaDRAFT_2884 1.03e-95 308.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales 135613|Chromatiales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_376622_1 414684.RC1_1718 2.39e-101 308.0 COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales 204441|Rhodospirillales Q Homospermidine synthase hss - 2.5.1.44 ko:K00808 ko00960,ko01110,map00960,map01110 - R00018 RC00053 ko00000,ko00001,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_866247_1 1408473.JHXO01000012_gene383 3.94e-176 507.0 COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,2FNXT@200643|Bacteroidia 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_47717_2 387093.SUN_0231 2.29e-33 118.0 COG0792@1|root,COG0792@2|Bacteria,1Q27V@1224|Proteobacteria,42V4E@68525|delta/epsilon subdivisions,2YQJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_508779_1 382464.ABSI01000012_gene2201 4.74e-30 123.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C k59_213946_1 572544.Ilyop_0408 0.0 1511.0 COG0178@1|root,COG0178@2|Bacteria,378AZ@32066|Fusobacteria 32066|Fusobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_735030_1 1249627.D779_3696 1.72e-41 156.0 COG0642@1|root,COG0834@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2TY@135613|Chromatiales 135613|Chromatiales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg,SBP_bac_3 k59_797857_1 572544.Ilyop_0233 1.46e-210 600.0 COG1227@1|root,COG1227@2|Bacteria,378Y0@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score ppaC - 3.6.1.1 ko:K15986 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - CBS,DHH,DHHA2 k59_797857_2 572544.Ilyop_1220 2.03e-271 760.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,378S3@32066|Fusobacteria 2|Bacteria C PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit hoxF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 ko:K18005 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_797861_1 1232437.KL662010_gene1572 4.78e-87 273.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales 28221|Deltaproteobacteria KT Sigma-54 interaction domain - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_638554_1 349161.Dred_2840 1.13e-23 99.8 COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,260TI@186807|Peptococcaceae 186801|Clostridia S PFAM ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_638554_2 469616.FMAG_01068 1.28e-136 394.0 28JQ0@1|root,2Z9FY@2|Bacteria,378QC@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - WYL k59_541002_1 709032.Sulku_1263 1.29e-133 404.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2YMSQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II k59_541002_2 1165841.SULAR_03777 1.09e-55 190.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,42N8E@68525|delta/epsilon subdivisions,2YNF0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_964880_1 1397527.Q670_04955 1.71e-18 80.9 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1XHKX@135619|Oceanospirillales 135619|Oceanospirillales J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_964880_2 1121405.dsmv_2306 5.03e-22 95.5 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2MN0D@213118|Desulfobacterales 28221|Deltaproteobacteria O Peptidase family M41 ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_606154_1 931276.Cspa_c35110 5.29e-25 95.5 COG3123@1|root,COG3123@2|Bacteria,1VBF3@1239|Firmicutes,24JI0@186801|Clostridia,36K51@31979|Clostridiaceae 186801|Clostridia S Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions ppnP - 2.4.2.1,2.4.2.2 ko:K09913 ko00230,ko00240,map00230,map00240 - R01561,R01570,R01863,R01876,R02147,R02296,R02297 RC00063,RC00122 ko00000,ko00001,ko01000 - - - DUF1255 k59_47721_1 326298.Suden_1933 1.89e-70 220.0 COG4121@1|root,COG4121@2|Bacteria,1Q8T8@1224|Proteobacteria,42RAP@68525|delta/epsilon subdivisions,2YP3B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_30 k59_181527_1 1121405.dsmv_0556 2.9e-36 137.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM ferredoxin - - - - - - - - - - - - DUF4445,Fer2 k59_964885_1 1537917.JU82_10930 1.52e-48 156.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2YPSQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iIT341.HP1270 Oxidored_q2 k59_964885_2 326298.Suden_1819 1.47e-73 226.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42RES@68525|delta/epsilon subdivisions,2YP9Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_181532_1 1458357.BG58_00640 2.72e-08 62.8 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VIMC@28216|Betaproteobacteria,1K1NC@119060|Burkholderiaceae 28216|Betaproteobacteria T PFAM ATP-binding region, ATPase domain protein dctB - 2.7.13.3 ko:K10125 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 k59_345222_1 1408439.JHXW01000003_gene1613 1e-33 116.0 COG1278@1|root,COG1278@2|Bacteria,37AZA@32066|Fusobacteria 32066|Fusobacteria K Cold shock protein cspE - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_345222_2 1408303.JNJJ01000053_gene1545 4.09e-43 150.0 COG3340@1|root,COG3340@2|Bacteria,1V6ZV@1239|Firmicutes,4HJCZ@91061|Bacilli,1ZHN8@1386|Bacillus 91061|Bacilli E Peptidase family S51 pepE - 3.4.13.21 ko:K05995 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S51 k59_11798_1 1249480.B649_02825 1.41e-175 514.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2YMB9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T chemotaxis protein cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_797894_1 1355368.JART01000014_gene562 4.74e-10 59.3 COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2YNPG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PAS domain - - - ko:K09155 - - - - ko00000 - - - Hemerythrin,PAS_10 k59_573028_1 933262.AXAM01000027_gene2082 3.96e-46 157.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales 28221|Deltaproteobacteria L SMART Chromosomal replication initiator DnaA domain - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_573028_2 933262.AXAM01000027_gene2082 4.11e-28 112.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales 28221|Deltaproteobacteria L SMART Chromosomal replication initiator DnaA domain - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_834081_1 929558.SMGD1_0424 7.17e-255 734.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,42M05@68525|delta/epsilon subdivisions,2YNMZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Bacterial NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_11810_1 1122605.KB893637_gene3349 4.15e-75 252.0 COG2335@1|root,COG2335@2|Bacteria,4NI6Z@976|Bacteroidetes,1IQ5T@117747|Sphingobacteriia 976|Bacteroidetes M Domain of unknown function - - - - - - - - - - - - DUF4993,Fasciclin k59_474107_1 1165841.SULAR_03732 7.07e-124 366.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2YNAU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - iIT341.HP1101 G6PD_C,G6PD_N k59_964905_1 1121439.dsat_0641 3.43e-35 135.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria,2MH87@213115|Desulfovibrionales 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_474108_1 1192034.CAP_2041 7.61e-25 102.0 COG0652@1|root,COG0652@2|Bacteria 2|Bacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_606172_1 273526.SMDB11_0982 0.000129 46.2 COG5649@1|root,COG5649@2|Bacteria,1ND08@1224|Proteobacteria,1SF0X@1236|Gammaproteobacteria,403V5@613|Serratia 1236|Gammaproteobacteria S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 k59_606172_2 387093.SUN_0491 6.71e-66 211.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ7@1224|Proteobacteria,43BJF@68525|delta/epsilon subdivisions,2YNM7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,sCache_like k59_932776_1 929558.SMGD1_1386 8.96e-63 203.0 COG0332@1|root,COG0332@2|Bacteria,1NAGY@1224|Proteobacteria,42P7S@68525|delta/epsilon subdivisions,2YNKQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III_C k59_671767_1 572477.Alvin_0397 4.3e-92 285.0 COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,1RR3H@1236|Gammaproteobacteria,1WW71@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD k59_866291_1 1454004.AW11_00158 4.15e-28 114.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1KQP5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_541033_1 883112.HMPREF9707_01483 1.7e-10 67.4 COG2801@1|root,COG2801@2|Bacteria,1TT8V@1239|Firmicutes,4HCE5@91061|Bacilli 91061|Bacilli L PFAM Integrase core domain - - - - - - - - - - - - HTH_23,HTH_28,HTH_29,rve k59_998140_2 765910.MARPU_04230 8.25e-35 126.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1WY2S@135613|Chromatiales 135613|Chromatiales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate tsaC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_932796_1 765912.Thimo_0912 4.42e-99 296.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1WX0Z@135613|Chromatiales 135613|Chromatiales L PFAM integrase - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve k59_866301_1 279714.FuraDRAFT_2681 2.98e-43 157.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,2KPMJ@206351|Neisseriales 206351|Neisseriales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_703568_1 1121920.AUAU01000001_gene2244 5.88e-51 164.0 COG3631@1|root,COG3631@2|Bacteria 2|Bacteria S light absorption - - - - - - - - - - - - SnoaL,SnoaL_2 k59_11839_1 498761.HM1_0638 3.44e-30 124.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - 7TMR-DISM_7TM,AAA_16,GAF,HATPase_c,HisKA,Hpt,Pkinase,Response_reg k59_638594_1 1056820.KB900643_gene851 1.12e-61 201.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RUI0@1236|Gammaproteobacteria,2PN0P@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P NMT1/THI5 like - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_735087_1 933262.AXAM01000106_gene2629 1.04e-60 193.0 COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,42UW2@68525|delta/epsilon subdivisions,2WQFD@28221|Deltaproteobacteria,2MNYG@213118|Desulfobacterales 28221|Deltaproteobacteria S ABC-type transport auxiliary lipoprotein component - - - ko:K09857 - - - - ko00000 - - - ABC_trans_aux k59_541042_1 177437.HRM2_29690 9.66e-59 204.0 COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,42NF1@68525|delta/epsilon subdivisions,2WK52@28221|Deltaproteobacteria,2MI9T@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the heat shock protein 70 family - - - - - - - - - - - - DUF3731,HSP70 k59_47782_1 1112216.JH594425_gene748 2.13e-21 99.8 COG0507@1|root,COG0507@2|Bacteria,1MUTR@1224|Proteobacteria,2TSQQ@28211|Alphaproteobacteria,2K2VF@204457|Sphingomonadales 204457|Sphingomonadales L Conjugal transfer protein - - - - - - - - - - - - AAA_30,MobA_MobL,Viral_helicase1 k59_932819_1 859657.RPSI07_mp0577 1.14e-75 248.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2VI04@28216|Betaproteobacteria,1K121@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 k59_310392_1 1168034.FH5T_06525 4.76e-80 263.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,2FM8X@200643|Bacteroidia 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_11863_1 929558.SMGD1_1686 8.38e-278 783.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4_10,Molybdopterin,NADH-G_4Fe-4S_3 k59_703592_2 387093.SUN_1521 1.06e-73 223.0 COG2246@1|root,COG2246@2|Bacteria,1RJUK@1224|Proteobacteria,42SU1@68525|delta/epsilon subdivisions,2YPQX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GtrA-like protein - - - - - - - - - - - - GtrA k59_703592_3 387093.SUN_0330 4.38e-56 182.0 COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,42PEU@68525|delta/epsilon subdivisions,2YP21@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_541048_1 563040.Saut_1116 7.5e-102 305.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2YMJ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_797945_1 713586.KB900536_gene2226 7.61e-111 347.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_797945_2 360106.CFF8240_1822 1.12e-31 120.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,42QPX@68525|delta/epsilon subdivisions,2YNW3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_797945_3 1198232.CYCME_0318 2.24e-15 75.5 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,460GP@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_115314_1 572477.Alvin_1048 3.55e-102 309.0 COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_115314_2 765912.Thimo_3319 1.96e-56 195.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_115315_1 1226322.HMPREF1545_03024 2.71e-68 228.0 COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,24A64@186801|Clostridia,2N86T@216572|Oscillospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_214653_1 400668.Mmwyl1_1070 3.2e-73 234.0 COG0739@1|root,COG3061@1|root,COG0739@2|Bacteria,COG3061@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1XHD2@135619|Oceanospirillales 135619|Oceanospirillales M Peptidase M23 - - - - - - - - - - - - OapA,Peptidase_M23 k59_798670_1 526218.Sterm_4011 2.67e-79 251.0 COG1879@1|root,COG1879@2|Bacteria,3793S@32066|Fusobacteria 2|Bacteria G Periplasmic binding protein domain - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_798670_2 1380763.BG53_10710 9.06e-79 251.0 COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4HCSN@91061|Bacilli,26SYM@186822|Paenibacillaceae 91061|Bacilli G Periplasmic substrate-binding component of the ATP-dependent ribose transport system - - - ko:K17213 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 k59_409612_1 1168034.FH5T_12700 2.58e-233 661.0 COG0480@1|root,COG0480@2|Bacteria,4NG4H@976|Bacteroidetes,2FN1G@200643|Bacteroidia 976|Bacteroidetes J elongation factor G fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_514418_1 1123228.AUIH01000091_gene568 1.45e-13 75.1 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XHYC@135619|Oceanospirillales 135619|Oceanospirillales L recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_282205_1 1236542.BALM01000002_gene967 0.000424 50.1 COG2931@1|root,COG3227@1|root,COG3266@1|root,COG4932@1|root,COG2931@2|Bacteria,COG3227@2|Bacteria,COG3266@2|Bacteria,COG4932@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria,2Q92C@267890|Shewanellaceae 1236|Gammaproteobacteria E peptidase M4 thermolysin proA GO:0005575,GO:0005576 3.4.24.25,3.4.24.26 ko:K01399,ko:K08604 ko01503,ko02024,ko05110,ko05111,map01503,map02024,map05110,map05111 - - - ko00000,ko00001,ko01000,ko01002 - - - FTP,PPC,PepSY,Peptidase_M4,Peptidase_M4_C k59_1034836_1 395495.Lcho_1695 4.95e-80 250.0 COG1653@1|root,COG1653@2|Bacteria,1MUYE@1224|Proteobacteria,2VJ0D@28216|Betaproteobacteria,1KKCQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria G Bacterial extracellular solute-binding protein - - - ko:K17315 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - SBP_bac_1 k59_1003640_1 1121405.dsmv_2750 3.62e-78 248.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Starch synthase catalytic - - 2.4.1.21,3.2.1.1 ko:K00703,ko:K01176 ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973 M00565 R02108,R02112,R02421,R11262 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GH13,GT5 - Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1 k59_677410_1 765911.Thivi_2803 7.32e-13 67.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1X0I7@135613|Chromatiales 135613|Chromatiales S CbbQ/NirQ/NorQ C-terminal - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_905087_1 76114.ebA3337 1.54e-123 377.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2VJIW@28216|Betaproteobacteria,2KV19@206389|Rhodocyclales 206389|Rhodocyclales L Integrase core domain - - - - - - - - - - - - rve k59_905087_2 1562701.BBOF01000090_gene517 1.48e-86 265.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2VMVE@28216|Betaproteobacteria,1K5SK@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_350613_1 1279038.KB907337_gene127 1.04e-27 113.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_350613_2 998674.ATTE01000001_gene2386 0.0 954.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase HA62_19490 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_350613_3 207954.MED92_08256 8.28e-30 110.0 COG3255@1|root,COG3255@2|Bacteria,1N206@1224|Proteobacteria,1S8RI@1236|Gammaproteobacteria,1XKS6@135619|Oceanospirillales 135619|Oceanospirillales I sterol carrier protein - - - - - - - - - - - - SCP2 k59_350613_4 207954.MED92_08261 5.6e-258 723.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1XICJ@135619|Oceanospirillales 135619|Oceanospirillales IQ involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_350613_5 1278309.KB907105_gene1424 1.51e-60 194.0 2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,1S48K@1236|Gammaproteobacteria,1XJRZ@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF2889) - - - - - - - - - - - - DUF2889 k59_644088_1 504832.OCAR_6068 5.41e-35 132.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2UQPA@28211|Alphaproteobacteria,3K2Z0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_644088_2 1304885.AUEY01000094_gene3532 8.48e-09 54.7 COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,42SWX@68525|delta/epsilon subdivisions,2WPJ0@28221|Deltaproteobacteria,2MK5C@213118|Desulfobacterales 28221|Deltaproteobacteria I MaoC like domain maoC - 4.2.1.55 ko:K17865 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R03027 RC00831 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas k59_219490_1 709032.Sulku_0939 5.03e-55 191.0 COG1315@1|root,COG1315@2|Bacteria,1R5P6@1224|Proteobacteria,42MAS@68525|delta/epsilon subdivisions,2YM7Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Flagellar Assembly Protein A - - - - - - - - - - - - FapA k59_1003643_1 1049564.TevJSym_cx00010 5.83e-262 727.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1JAD3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_905099_1 484770.UFO1_2954 7.32e-38 141.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,4H31M@909932|Negativicutes 909932|Negativicutes C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4,Fer4_10,Fer4_4,Fer4_8,RnfC_N,SLBB k59_414231_1 1537917.JU82_02660 1.89e-107 327.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YMN1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DEAD box helicase family deaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C k59_644093_1 572480.Arnit_1919 5.6e-07 61.2 COG2982@1|root,COG3164@1|root,COG2982@2|Bacteria,COG3164@2|Bacteria,1QA6E@1224|Proteobacteria,42NCN@68525|delta/epsilon subdivisions,2YM89@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M AsmA-like C-terminal region - - - - - - - - - - - - AsmA_1,DUF3971 k59_803442_1 269796.Rru_A1674 0.000169 43.9 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,2JPA7@204441|Rhodospirillales 204441|Rhodospirillales I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) ispDF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_803442_2 572544.Ilyop_1816 5.99e-37 138.0 COG0488@1|root,COG0488@2|Bacteria,37913@32066|Fusobacteria 32066|Fusobacteria S ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn k59_282217_2 709032.Sulku_2464 8.71e-104 306.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42R04@68525|delta/epsilon subdivisions,2YSXM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG k59_382050_1 1944.JOAZ01000007_gene2436 1.23e-84 281.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2GIYE@201174|Actinobacteria,41AAP@629295|Streptomyces griseus group 201174|Actinobacteria EQ Hydantoinase B/oxoprolinase oplA - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - iNJ661.Rv0266c Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_708992_2 675806.VII_003778 0.000416 43.9 COG1192@1|root,COG1192@2|Bacteria,1QR38@1224|Proteobacteria,1SJEB@1236|Gammaproteobacteria 1236|Gammaproteobacteria D AAA domain - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_677420_1 523791.Kkor_0676 1.38e-54 182.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1XHFQ@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_350633_1 485916.Dtox_3926 1.08e-77 246.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1UQRR@1239|Firmicutes,24BSD@186801|Clostridia,2645U@186807|Peptococcaceae 186801|Clostridia L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_154370_1 709032.Sulku_0507 8.71e-15 72.8 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2YM85@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_N k59_154370_2 710393.HSUHS1_0791 7.66e-15 69.7 COG1551@1|root,COG1551@2|Bacteria,1Q4KC@1224|Proteobacteria,42W0C@68525|delta/epsilon subdivisions,2YQ7K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the CsrA family csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_154370_3 1172190.M947_06730 3.27e-74 229.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,42RGS@68525|delta/epsilon subdivisions,2YNY5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N k59_479671_1 945713.IALB_0051 7.92e-58 184.0 2C945@1|root,32W5M@2|Bacteria 2|Bacteria - - - - 5.4.4.1 ko:K01865 ko00627,ko01120,map00627,map01120 - - - ko00000,ko00001,ko01000 - - - - k59_905107_1 1265505.ATUG01000002_gene2036 1.27e-33 119.0 2DI0Z@1|root,32UA6@2|Bacteria,1N1UY@1224|Proteobacteria,42UQX@68525|delta/epsilon subdivisions,2WR5W@28221|Deltaproteobacteria,2MKRN@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_905110_1 1535422.ND16A_3528 5.25e-50 169.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,1RNFH@1236|Gammaproteobacteria,2Q79P@267889|Colwelliaceae 1236|Gammaproteobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_1034842_1 1131553.JIBI01000004_gene351 1.69e-68 217.0 COG1073@1|root,COG1073@2|Bacteria,1N595@1224|Proteobacteria 1224|Proteobacteria S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_17471_1 991905.SL003B_2986 9.87e-126 374.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,4BPMM@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF853) yjgR - - ko:K06915 - - - - ko00000 - - - DUF853 k59_677431_1 335543.Sfum_2077 1.55e-103 317.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42P0M@68525|delta/epsilon subdivisions,2WJMC@28221|Deltaproteobacteria,2MR1W@213462|Syntrophobacterales 28221|Deltaproteobacteria I AMP-dependent synthetase and ligase - - 6.2.1.1,6.2.1.32 ko:K01895,ko:K08295 ko00010,ko00620,ko00627,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00627,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R00982,R01354 RC00004,RC00012,RC00043,RC00070,RC00174,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_514447_1 399739.Pmen_4620 4.03e-52 185.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1YCU3@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_446628_1 1127673.GLIP_1841 1.19e-93 287.0 COG5434@1|root,COG5434@2|Bacteria,1MXP8@1224|Proteobacteria,1RRJZ@1236|Gammaproteobacteria,4644J@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_774189_1 563040.Saut_1141 1.12e-95 287.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,42Q58@68525|delta/epsilon subdivisions,2YNDQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P K -dependent Na Ca exchanger - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_283013_1 572544.Ilyop_1461 1.47e-146 424.0 COG1015@1|root,COG1015@2|Bacteria,378FA@32066|Fusobacteria 32066|Fusobacteria G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme k59_283013_2 1122172.KB890259_gene826 1.61e-100 298.0 COG0274@1|root,COG0274@2|Bacteria,378X5@32066|Fusobacteria 32066|Fusobacteria H Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_316435_1 1121937.AUHJ01000013_gene908 2.62e-19 87.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,46412@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275 DHQ_synthase k59_316435_2 592316.Pat9b_3689 1.11e-32 120.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,3VY0T@53335|Pantoea 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_155123_1 1227268.HMPREF1552_00362 5.34e-69 210.0 COG0048@1|root,COG0048@2|Bacteria,37A4D@32066|Fusobacteria 32066|Fusobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_155123_2 572544.Ilyop_1816 1.86e-216 618.0 COG0488@1|root,COG0488@2|Bacteria,37913@32066|Fusobacteria 32066|Fusobacteria S ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn k59_121620_1 123214.PERMA_1960 4.57e-43 149.0 2AW2B@1|root,31MX2@2|Bacteria,2G5BR@200783|Aquificae 200783|Aquificae S LPP20 lipoprotein - - - - - - - - - - - - LPP20 k59_579021_1 1187851.A33M_4208 5.65e-157 454.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum 28211|Alphaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_88667_2 243159.AFE_1997 8.54e-11 62.4 COG2197@1|root,COG2197@2|Bacteria,1R4TP@1224|Proteobacteria,1RR98@1236|Gammaproteobacteria,2NDDQ@225057|Acidithiobacillales 225057|Acidithiobacillales K regulator, LuxR - - - ko:K07782 ko02020,ko02024,ko02026,map02020,map02024,map02026 - - - ko00000,ko00001,ko03000 - - - Autoind_bind,GerE k59_382680_1 326298.Suden_1047 3.75e-176 512.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2YMT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_382680_2 563040.Saut_1114 4.34e-64 204.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2YMR0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_351398_1 640081.Dsui_1630 3.87e-53 176.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,2KUZH@206389|Rhodocyclales 206389|Rhodocyclales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_351398_2 83406.HDN1F_11970 1.26e-10 58.2 COG4736@1|root,COG4736@2|Bacteria 2|Bacteria O Cbb3-type cytochrome oxidase ccoQ - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_351398_3 312153.Pnuc_0454 0.000143 43.5 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,1K0BT@119060|Burkholderiaceae 28216|Betaproteobacteria C cytochrome c oxidase, cbb3-type, subunit II ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_480319_1 426716.JOAJ01000007_gene4277 1.68e-65 213.0 COG3293@1|root,COG3293@2|Bacteria,2GN92@201174|Actinobacteria,4FXKZ@85025|Nocardiaceae 201174|Actinobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_1004326_1 713587.THITH_03175 3.37e-12 71.2 COG0457@1|root,COG0457@2|Bacteria,1QW7M@1224|Proteobacteria 1224|Proteobacteria U Tetratricopeptide repeats - - - - - - - - - - - - Asp_protease_2,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_1004326_2 857087.Metme_2422 1.49e-31 123.0 COG3064@1|root,COG3064@2|Bacteria,1QW8P@1224|Proteobacteria,1T5BR@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157 k59_187694_1 155515.JP36_06690 4.52e-45 150.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1Y8GG@135625|Pasteurellales 135625|Pasteurellales J Binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_644814_1 765910.MARPU_06625 5.18e-43 147.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,1WXQD@135613|Chromatiales 135613|Chromatiales O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_121634_1 1123024.AUII01000003_gene3482 6.66e-24 100.0 COG1680@1|root,COG1680@2|Bacteria,2H2SY@201174|Actinobacteria,4DXGA@85010|Pseudonocardiales 201174|Actinobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_283022_1 1123393.KB891329_gene1060 8.75e-15 80.5 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - CHB_HEX_C_1,CotH,Flg_new,Fn3_assoc,LRR_5,LTD,Peptidase_S9,SpvB,TcdB_toxin_midN,VCBS k59_971172_1 935836.JAEL01000003_gene412 5.74e-43 154.0 COG2807@1|root,COG2807@2|Bacteria,1UJ09@1239|Firmicutes,4ISZA@91061|Bacilli,1ZSFH@1386|Bacillus 91061|Bacilli P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_187708_1 83406.HDN1F_00910 3.57e-16 80.9 COG3159@1|root,COG3159@2|Bacteria,1RD7B@1224|Proteobacteria,1S539@1236|Gammaproteobacteria,1JBVY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF484 - - - ko:K09921 - - - - ko00000 - - - DUF484 k59_774913_1 1123075.AUDP01000004_gene857 1.06e-139 409.0 COG3949@1|root,COG3949@2|Bacteria,1TSC0@1239|Firmicutes,24A43@186801|Clostridia 186801|Clostridia J Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - - k59_414946_1 90814.KL370891_gene136 8.4e-11 64.7 COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,1RNX1@1236|Gammaproteobacteria,4608N@72273|Thiotrichales 72273|Thiotrichales MU TIGRFAM type I secretion outer membrane protein, TolC family - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP k59_644844_1 247633.GP2143_07424 2.32e-30 109.0 2E588@1|root,3300P@2|Bacteria,1N79I@1224|Proteobacteria,1SCYA@1236|Gammaproteobacteria,1J6XU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF5062) VVA0683 - - - - - - - - - - - DUF5062 k59_644844_2 105559.Nwat_2043 2.2e-16 80.9 COG0412@1|root,COG0412@2|Bacteria,1QW3K@1224|Proteobacteria,1S38F@1236|Gammaproteobacteria,1X0ND@135613|Chromatiales 135613|Chromatiales Q Alpha/beta hydrolase family - - - - - - - - - - - - - k59_316477_1 1288963.ADIS_3894 5.36e-53 182.0 COG5433@1|root,COG5433@2|Bacteria,4P5P2@976|Bacteroidetes 976|Bacteroidetes L transposase activity - - - - - - - - - - - - - k59_414951_1 391615.ABSJ01000041_gene64 6.6e-44 150.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,1J6HM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_414951_2 883126.HMPREF9710_03140 3.66e-16 78.6 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,4740Q@75682|Oxalobacteraceae 28216|Betaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_283046_1 1121405.dsmv_3573 1.65e-79 239.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales 28221|Deltaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_251911_1 439235.Dalk_1522 2.71e-143 407.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,42NE5@68525|delta/epsilon subdivisions,2WJ14@28221|Deltaproteobacteria,2MJCK@213118|Desulfobacterales 28221|Deltaproteobacteria P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_283049_1 1049564.TevJSym_bl00150 6.47e-70 224.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1J4S0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_480344_1 563040.Saut_1265 1.28e-36 135.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2YN0D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J MiaB-like tRNA modifying enzyme yqeV - - - - - - - - - - - Radical_SAM,UPF0004 k59_316484_1 1168034.FH5T_09560 1.68e-143 429.0 COG1198@1|root,COG1198@2|Bacteria,4NFHB@976|Bacteroidetes,2FN6Z@200643|Bacteroidia 976|Bacteroidetes L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_840348_1 1122212.AULO01000010_gene127 4.65e-101 301.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1XHC4@135619|Oceanospirillales 135619|Oceanospirillales G catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_879448_1 929556.Solca_4182 4.25e-75 241.0 COG0008@1|root,COG0008@2|Bacteria,4NFCC@976|Bacteroidetes,1IQC9@117747|Sphingobacteriia 976|Bacteroidetes J Glutaminyl-tRNA synthetase glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_486755_1 1123037.AUDE01000013_gene559 1.83e-18 83.6 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,4NEDY@976|Bacteroidetes,1HXFG@117743|Flavobacteriia 976|Bacteroidetes HJM cyanophycin synthetase cphA - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Mur_ligase_C,Mur_ligase_M,RimK k59_486755_2 1046627.BZARG_1157 3.56e-54 177.0 COG4242@1|root,COG4242@2|Bacteria,4NI55@976|Bacteroidetes,1HZY7@117743|Flavobacteriia 976|Bacteroidetes PQ Belongs to the peptidase S51 family cphB - 3.4.15.6 ko:K13282 - - R09722 RC00064,RC00141 ko00000,ko01000,ko01002 - - - Peptidase_S51 k59_747772_1 987059.RBXJA2T_13184 0.000395 47.0 COG0824@1|root,COG0824@2|Bacteria,1MZTU@1224|Proteobacteria,2VSY8@28216|Betaproteobacteria,1KM7F@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Thioesterase superfamily fcbC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_290072_1 1500893.JQNB01000001_gene2930 2.1e-84 261.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1X4JK@135614|Xanthomonadales 135614|Xanthomonadales E alanine dehydrogenase - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1043383_1 396588.Tgr7_0574 1.3e-78 246.0 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales 135613|Chromatiales K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,DUF3335 k59_747777_2 1249480.B649_03785 5.08e-17 77.8 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,42PTX@68525|delta/epsilon subdivisions,2YMNS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_456046_2 1380394.JADL01000007_gene4630 3.25e-21 94.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria 1224|Proteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_846966_1 1408254.T458_24165 7.22e-60 196.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,26QZ3@186822|Paenibacillaceae 91061|Bacilli P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,BPD_transp_1,OppC_N,oligo_HPY k59_912497_1 768671.ThimaDRAFT_2233 4.55e-56 179.0 COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,1S6P0@1236|Gammaproteobacteria,1WZ8Y@135613|Chromatiales 135613|Chromatiales S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_61435_1 694427.Palpr_0320 2.39e-87 274.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,4NI8S@976|Bacteroidetes,2FWS5@200643|Bacteroidia,22ZUE@171551|Porphyromonadaceae 976|Bacteroidetes C Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S - - 1.5.5.1 ko:K00311,ko:K00313 - - - - ko00000,ko01000 - - - DAO,ETF_QO,NAD_binding_8 k59_61436_1 177437.HRM2_41800 1.54e-66 216.0 2DBU2@1|root,2ZB3S@2|Bacteria,1N1MT@1224|Proteobacteria,42VJX@68525|delta/epsilon subdivisions,2WSPP@28221|Deltaproteobacteria,2MNKM@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - DDE_Tnp_1_4 k59_456062_1 1168034.FH5T_05880 4.96e-163 466.0 COG0017@1|root,COG0017@2|Bacteria,4NDY4@976|Bacteroidetes,2FKYI@200643|Bacteroidia 976|Bacteroidetes J Asparaginyl-tRNA synthetase asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_195157_1 572544.Ilyop_1135 3.92e-51 168.0 COG2190@1|root,COG2190@2|Bacteria,37A1G@32066|Fusobacteria 32066|Fusobacteria G PTS system crr - - ko:K02777 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1 - - PTS_EIIA_1 k59_195157_2 1280689.AUJC01000008_gene2984 1.06e-144 434.0 COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,1TP5X@1239|Firmicutes,247WT@186801|Clostridia,36DI9@31979|Clostridiaceae 186801|Clostridia G Pts system - - - ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 M00271 - - ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_195157_3 84531.JMTZ01000051_gene912 1.89e-45 160.0 COG1878@1|root,COG1878@2|Bacteria,1R8IH@1224|Proteobacteria,1S46Y@1236|Gammaproteobacteria,1X5VG@135614|Xanthomonadales 135614|Xanthomonadales S Putative cyclase - - - - - - - - - - - - Cyclase k59_195157_4 742733.HMPREF9469_04594 4.16e-58 181.0 arCOG09714@1|root,316P9@2|Bacteria,1V7WP@1239|Firmicutes,25CTN@186801|Clostridia,221I4@1506553|Lachnoclostridium 186801|Clostridia S COG NOG16854 non supervised orthologous group - - - - - - - - - - - - - k59_195157_5 1232446.BAIE02000048_gene227 2.7e-58 182.0 arCOG09714@1|root,33H0I@2|Bacteria,1VG6M@1239|Firmicutes,24PAY@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_195157_6 1232446.BAIE02000048_gene225 1.73e-253 705.0 COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 1 family abgA - 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT1 - Glyco_hydro_1 k59_811476_1 697282.Mettu_3253 9.78e-51 173.0 COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,1XEHI@135618|Methylococcales 135618|Methylococcales M Bacterial lipid A biosynthesis acyltransferase - - - - - - - - - - - - Lip_A_acyltrans k59_747793_1 1211114.ALIP01000156_gene2992 1.26e-54 178.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1X63M@135614|Xanthomonadales 135614|Xanthomonadales E GDSL-like Lipase/Acylhydrolase tesA - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 k59_747793_2 243233.MCA1687 4.11e-149 435.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales 135618|Methylococcales S AAA-like domain - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 k59_290101_1 1219375.CM002139_gene738 2.55e-26 112.0 COG2911@1|root,COG2911@2|Bacteria,1N4HK@1224|Proteobacteria,1SAHK@1236|Gammaproteobacteria,1X3U3@135614|Xanthomonadales 135614|Xanthomonadales S Protein conserved in bacteria - - - - - - - - - - - - - k59_619672_1 326298.Suden_0126 1.56e-19 87.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,42NI1@68525|delta/epsilon subdivisions,2YMHQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_619672_2 1537917.JU82_00630 2.17e-75 229.0 COG3545@1|root,COG3545@2|Bacteria,1MZB5@1224|Proteobacteria,43B8G@68525|delta/epsilon subdivisions,2YT6R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Serine hydrolase - - - ko:K07002 - - - - ko00000 - - - Ser_hydrolase k59_290109_1 2340.JV46_15990 8.18e-24 93.2 COG0316@1|root,COG0316@2|Bacteria,1RFIX@1224|Proteobacteria,1S3SB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the HesB IscA family - - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_290109_2 1049564.TevJSym_as00110 2.03e-33 120.0 2B7TJ@1|root,32102@2|Bacteria,1RHKS@1224|Proteobacteria,1S7PY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF5063) - - - - - - - - - - - - DUF5063 k59_978150_1 1168034.FH5T_07890 1.37e-22 94.4 2C1B9@1|root,32R9M@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4292) - - - - - - - - - - - - DUF4292 k59_978150_2 927658.AJUM01000037_gene1969 0.0002 47.0 COG4942@1|root,COG4942@2|Bacteria,4NH2T@976|Bacteroidetes,2FN4U@200643|Bacteroidia,3XIMA@558415|Marinilabiliaceae 976|Bacteroidetes D Peptidase family M23 envC - - - - - - - - - - - Peptidase_M23 k59_912519_1 1168034.FH5T_10180 4.13e-130 394.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,2FMFA@200643|Bacteroidia 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_586764_1 1121896.JMLU01000052_gene1260 5.12e-25 108.0 2BFD6@1|root,3296M@2|Bacteria,4NQWY@976|Bacteroidetes,1I31C@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_716750_1 177437.HRM2_33940 1.27e-53 187.0 COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria,433HE@68525|delta/epsilon subdivisions,2WYHG@28221|Deltaproteobacteria,2MP7M@213118|Desulfobacterales 28221|Deltaproteobacteria L Domain of unknown function (DUF4277) - - - - - - - - - - - - DUF4277 k59_811500_1 2340.JV46_11600 4.01e-28 107.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,1J674@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S HAD-hyrolase-like gph GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006040,GO:0006082,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009254,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019752,GO:0030203,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097172,GO:1901135,GO:1901360,GO:1901564 3.1.3.105,3.1.3.18 ko:K01091,ko:K22292 ko00520,ko00630,ko01100,ko01110,ko01130,map00520,map00630,map01100,map01110,map01130 - R01334,R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_811500_2 553385.JEMF01000078_gene664 7.98e-57 184.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1XH4S@135619|Oceanospirillales 135619|Oceanospirillales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_978155_1 981327.F925_01632 1.16e-14 68.9 COG2155@1|root,COG2155@2|Bacteria,1N77I@1224|Proteobacteria,1SHMF@1236|Gammaproteobacteria,3NPGK@468|Moraxellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF378) - - - ko:K09779 - - - - ko00000 - - - DUF378 k59_978155_2 1379698.RBG1_1C00001G1686 8.9e-194 557.0 COG1217@1|root,COG1217@2|Bacteria,2NNY7@2323|unclassified Bacteria 2|Bacteria T Elongation factor G C-terminus typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2 k59_163154_1 247634.GPB2148_544 1.11e-41 150.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_651776_1 1537917.JU82_09950 8.69e-68 211.0 COG3166@1|root,COG3166@2|Bacteria,1Q1VC@1224|Proteobacteria,42UGS@68525|delta/epsilon subdivisions,2YPY1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU PFAM Fimbrial assembly family protein - - - - - - - - - - - - - k59_651776_2 929558.SMGD1_1799 6.13e-22 96.7 2BQX9@1|root,32JUG@2|Bacteria,1Q2H0@1224|Proteobacteria,42VPF@68525|delta/epsilon subdivisions,2YQMK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_912536_1 765912.Thimo_2268 2.58e-48 172.0 COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_95597_1 326427.Cagg_0848 1.19e-12 70.5 COG1968@1|root,COG1968@2|Bacteria,2G6F7@200795|Chloroflexi,375SW@32061|Chloroflexia 32061|Chloroflexia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_747832_1 1453501.JELR01000002_gene1029 1.74e-28 112.0 COG1842@1|root,COG1842@2|Bacteria,1NB0D@1224|Proteobacteria,1RTFI@1236|Gammaproteobacteria,467CV@72275|Alteromonadaceae 1236|Gammaproteobacteria KT PspA/IM30 family - - - - - - - - - - - - PspA_IM30 k59_259029_2 717774.Marme_0712 1.25e-43 147.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1XKE3@135619|Oceanospirillales 135619|Oceanospirillales H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_290140_1 1168034.FH5T_19740 2.54e-114 338.0 COG2873@1|root,COG2873@2|Bacteria,4NE27@976|Bacteroidetes,2FMQX@200643|Bacteroidia 976|Bacteroidetes E O-acetylhomoserine aminocarboxypropyltransferase cysteine synthase metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_195217_1 588581.Cpap_0079 5.58e-51 186.0 COG2227@1|root,COG2230@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG2230@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia 186801|Clostridia Q Beta-ketoacyl synthase - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_128688_1 1384066.JAGT01000001_gene263 1.46e-05 49.7 COG2382@1|root,COG3507@1|root,COG2382@2|Bacteria,COG3507@2|Bacteria,1TR04@1239|Firmicutes,24ATC@186801|Clostridia,3WG7I@541000|Ruminococcaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.55 ko:K15921 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - CBM6,GH43 - AbfB,Big_3,CBM_2,CBM_4_9,CBM_6,Dockerin_1,Esterase,Glyco_hydro_43,RicinB_lectin_2 k59_1043488_1 523791.Kkor_2176 8.62e-28 117.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1XHWC@135619|Oceanospirillales 135619|Oceanospirillales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1011223_1 870187.Thini_3149 6.68e-08 53.5 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,460NH@72273|Thiotrichales 72273|Thiotrichales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_879518_1 1434325.AZQN01000006_gene3439 2.67e-06 48.5 COG0115@1|root,COG0115@2|Bacteria,4NSFJ@976|Bacteroidetes,47PY5@768503|Cytophagia 976|Bacteroidetes EH Amino-transferase class IV - - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k59_879518_2 749222.Nitsa_0154 3.5e-82 249.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,43ADI@68525|delta/epsilon subdivisions,2YT1T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_685482_1 1297570.MESS4_590054 2.12e-12 70.1 COG1073@1|root,COG1073@2|Bacteria,1MYAS@1224|Proteobacteria,2UAHA@28211|Alphaproteobacteria,43HV2@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_685482_2 377629.TERTU_4167 3.39e-10 63.2 COG2010@1|root,COG2010@2|Bacteria,1QYUH@1224|Proteobacteria,1T3V8@1236|Gammaproteobacteria,2PQ4Q@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_322959_1 572544.Ilyop_1746 8.59e-51 174.0 COG0579@1|root,COG1251@1|root,COG0579@2|Bacteria,COG1251@2|Bacteria,378T7@32066|Fusobacteria 32066|Fusobacteria C BFD-like [2Fe-2S] binding domain - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD k59_322959_2 523794.Lebu_0476 9.28e-55 185.0 COG0554@1|root,COG0554@2|Bacteria,3799Z@32066|Fusobacteria 32066|Fusobacteria H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_880157_1 1121931.AUHG01000016_gene1001 3.21e-71 233.0 COG2271@1|root,COG2271@2|Bacteria,4NK2M@976|Bacteroidetes,1I107@117743|Flavobacteriia 976|Bacteroidetes G Acetyl-coenzyme A transporter 1 - - - - - - - - - - - - MFS_1 k59_259684_1 543913.D521_0685 1.46e-28 109.0 COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,1KQVX@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U MotA/TolQ/ExbB proton channel family exbB1 - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_259684_2 935863.AWZR01000001_gene1559 2.8e-21 88.2 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S9R6@1236|Gammaproteobacteria,1X6GQ@135614|Xanthomonadales 135614|Xanthomonadales U Biopolymer exbD1 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_748371_1 1168034.FH5T_10605 1.64e-77 243.0 COG3087@1|root,COG3087@2|Bacteria,4NF9U@976|Bacteroidetes 976|Bacteroidetes D sporulation - - - - - - - - - - - - SPOR k59_946877_1 379066.GAU_0813 1.49e-39 145.0 COG0187@1|root,COG0187@2|Bacteria,1ZSP9@142182|Gemmatimonadetes 142182|Gemmatimonadetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_487376_1 491952.Mar181_2286 5.48e-67 213.0 297A5@1|root,2ZUHQ@2|Bacteria,1MYVB@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4145) - - - - - - - - - - - - DUF4145 k59_259701_1 1121346.KB899824_gene3016 3.26e-29 117.0 COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,4HA9K@91061|Bacilli,26RXB@186822|Paenibacillaceae 91061|Bacilli J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_620311_1 1211813.CAPH01000009_gene276 4.27e-25 109.0 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,2FNBJ@200643|Bacteroidia,22UXT@171550|Rikenellaceae 976|Bacteroidetes S TamB, inner membrane protein subunit of TAM complex - - - - - - - - - - - - TamB k59_978795_1 411474.COPEUT_01264 2.12e-27 108.0 COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia 186801|Clostridia F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_978795_2 357809.Cphy_2874 5.77e-56 181.0 COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,21XWW@1506553|Lachnoclostridium 186801|Clostridia G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS19265 TIM k59_259702_1 1191523.MROS_0559 1.05e-16 86.7 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec k59_62025_1 1168034.FH5T_06720 4.34e-102 317.0 COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,2FMI1@200643|Bacteroidia 976|Bacteroidetes E peptidase S46 dpp7 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009987,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033218,GO:0034641,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_S46 k59_913142_1 1042156.CXIVA_00010 1.35e-40 148.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,36DMV@31979|Clostridiaceae 186801|Clostridia O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_166987_2 709032.Sulku_0479 1.18e-131 383.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,42N2Y@68525|delta/epsilon subdivisions,2YMHG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar motor switch protein fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_395524_1 391587.KAOT1_20017 1.02e-124 365.0 COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,1HXDJ@117743|Flavobacteriia 976|Bacteroidetes L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - rve k59_395524_2 391587.KAOT1_20012 1.8e-52 169.0 COG2963@1|root,COG2963@2|Bacteria,4NQGJ@976|Bacteroidetes,1I2UE@117743|Flavobacteriia 976|Bacteroidetes L COG2963 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28 k59_199215_1 1121374.KB891577_gene3171 3.94e-08 58.5 2E62S@1|root,330RV@2|Bacteria,1N7P9@1224|Proteobacteria,1SBFK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_918871_1 572544.Ilyop_0359 1.24e-87 281.0 COG1934@1|root,COG1934@2|Bacteria,37CUD@32066|Fusobacteria 32066|Fusobacteria S Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm - - - - - - - - - - - - LptC,OstA k59_983695_1 469616.FMAG_00300 7.4e-68 218.0 COG1004@1|root,COG1004@2|Bacteria,379NW@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_362670_1 1247024.JRLH01000016_gene1694 1.31e-05 44.3 2EG8N@1|root,33A0G@2|Bacteria,1NHU3@1224|Proteobacteria,1SECH@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_362670_3 1283300.ATXB01000002_gene2597 2.1e-52 177.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,1XF1M@135618|Methylococcales 135618|Methylococcales F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_362670_4 1249627.D779_1268 7.29e-116 345.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1WWQN@135613|Chromatiales 135613|Chromatiales H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_362670_5 323261.Noc_1493 3.17e-253 716.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1WWJW@135613|Chromatiales 135613|Chromatiales S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_362670_6 1123228.AUIH01000005_gene690 3.67e-29 115.0 290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,1S3RZ@1236|Gammaproteobacteria,1XKS8@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_362670_7 1049564.TevJSym_af00670 2.27e-203 573.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,1J50C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Na+ dependent nucleoside transporter N-terminus nupX GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642 - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_362670_8 713586.KB900536_gene1716 1.34e-34 125.0 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TerB k59_297270_1 472759.Nhal_2813 5.08e-44 156.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_2222_2 1500893.JQNB01000001_gene2016 3.58e-116 348.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1X4GX@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_330338_1 987059.RBXJA2T_16062 3.87e-51 163.0 COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,2VTRD@28216|Betaproteobacteria 28216|Betaproteobacteria S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k59_330338_2 265072.Mfla_0384 3.32e-20 82.4 COG3526@1|root,COG3526@2|Bacteria,1MZ5V@1224|Proteobacteria,2VUXZ@28216|Betaproteobacteria,2KN56@206350|Nitrosomonadales 206350|Nitrosomonadales O Rdx family - - - ko:K07401 - - - - ko00000 - - - Rdx k59_134222_1 990073.ATHU01000001_gene1598 4.42e-109 330.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2YNK4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_820400_1 391008.Smal_0932 2.14e-76 240.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1X4F6@135614|Xanthomonadales 135614|Xanthomonadales NU twitching motility protein pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_722359_1 391623.TERMP_00347 4.05e-53 186.0 COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,243RK@183968|Thermococci 183968|Thermococci C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_722359_2 158190.SpiGrapes_3211 1.24e-128 374.0 COG1013@1|root,COG1013@2|Bacteria,2J6R4@203691|Spirochaetes 203691|Spirochaetes C oxidoreductase beta subunit - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_722359_3 1121289.JHVL01000028_gene508 8.38e-37 127.0 COG0640@1|root,COG0640@2|Bacteria,1V6CU@1239|Firmicutes,24R9E@186801|Clostridia,36JVZ@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892,ko:K21903 - - - - ko00000,ko03000 - - - HTH_5 k59_722359_4 1304284.L21TH_1668 2.25e-84 259.0 COG0701@1|root,COG0701@2|Bacteria,1TQC7@1239|Firmicutes,24A02@186801|Clostridia,36EPA@31979|Clostridiaceae 186801|Clostridia S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_918891_1 1236541.BALL01000006_gene1039 1.44e-55 185.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,2QADP@267890|Shewanellaceae 1236|Gammaproteobacteria H Belongs to the ribF family ribF GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_0025,iJN746.PP_0602 FAD_syn,Flavokinase k59_918891_2 1123371.ATXH01000004_gene1695 2.39e-08 55.1 COG0060@1|root,COG0060@2|Bacteria,2GGVX@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_134233_1 1026882.MAMP_02766 7.12e-36 128.0 COG0500@1|root,COG2226@2|Bacteria,1QXB0@1224|Proteobacteria,1T36U@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_134233_2 1396141.BATP01000051_gene3375 9.79e-12 66.2 COG0438@1|root,COG0438@2|Bacteria,46U78@74201|Verrucomicrobia,2IVJU@203494|Verrucomicrobiae 203494|Verrucomicrobiae M Glycosyl transferase 4-like - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_951371_2 655815.ZPR_4192 2.28e-06 55.5 COG0500@1|root,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,1HYS0@117743|Flavobacteriia 976|Bacteroidetes Q ubiE/COQ5 methyltransferase family - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - Methyltransf_11,Methyltransf_31 k59_951371_3 756499.Desde_2677 3.64e-55 176.0 COG0346@1|root,COG0346@2|Bacteria,1V6CB@1239|Firmicutes,25BFW@186801|Clostridia,265DN@186807|Peptococcaceae 186801|Clostridia E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase,Glyoxalase_2 k59_297284_1 1248916.ANFY01000011_gene1138 0.000166 45.8 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,2K117@204457|Sphingomonadales 204457|Sphingomonadales E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_297284_2 1463864.JOGO01000117_gene705 8.39e-11 62.4 COG1024@1|root,COG1024@2|Bacteria,2I9MR@201174|Actinobacteria 201174|Actinobacteria I Enoyl-CoA hydratase echA8_1 - - - - - - - - - - - ECH_1 k59_657443_1 396588.Tgr7_1396 5.8e-111 334.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales 135613|Chromatiales S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP k59_493678_1 1224318.DT73_01210 5.77e-92 280.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1S0KW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Molecular chaperone GroES - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_886028_1 1239962.C943_00054 6.31e-08 60.1 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47KW1@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,TPR_12,TPR_8 k59_396250_1 1131553.JIBI01000033_gene2333 4.89e-95 293.0 COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2VM55@28216|Betaproteobacteria 28216|Betaproteobacteria EJ Psort location Cytoplasmic, score 9.26 ansA - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_167852_1 929558.SMGD1_0295 9.02e-105 314.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2YMC8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_984420_2 1165841.SULAR_06668 3.6e-123 354.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2YTJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_363482_1 1122927.KB895430_gene42 0.000494 48.9 COG2207@1|root,COG2207@2|Bacteria,1V029@1239|Firmicutes,4HUSY@91061|Bacilli,274DQ@186822|Paenibacillaceae 91061|Bacilli K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_722995_1 1168034.FH5T_20500 4.04e-97 286.0 COG1611@1|root,COG1611@2|Bacteria,4NGWU@976|Bacteroidetes,2FNYZ@200643|Bacteroidia 976|Bacteroidetes S Belongs to the LOG family yvdD - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_722995_2 1168034.FH5T_20495 1.22e-45 161.0 COG0187@1|root,COG0187@2|Bacteria,4NE0P@976|Bacteroidetes,2FPG7@200643|Bacteroidia 976|Bacteroidetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_199858_2 1492922.GY26_01705 1.09e-26 101.0 COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria,1SE7J@1236|Gammaproteobacteria,1J77U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K MerR HTH family regulatory protein cbpM - - ko:K18997 - - - - ko00000,ko03036 - - - MerR_2 k59_199858_3 1127673.GLIP_3649 2.23e-35 129.0 COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,1RN1A@1236|Gammaproteobacteria,46A7S@72275|Alteromonadaceae 1236|Gammaproteobacteria S Methyltransferase - - - - - - - - - - - - - k59_1017185_1 1265310.CCBD010000043_gene2225 6.78e-12 68.9 COG1052@1|root,COG1052@2|Bacteria,2HBNQ@201174|Actinobacteria,2346H@1762|Mycobacteriaceae 201174|Actinobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_1017185_2 639030.JHVA01000001_gene1161 4.53e-77 243.0 COG0191@1|root,COG0191@2|Bacteria,3Y5I1@57723|Acidobacteria,2JJXG@204432|Acidobacteriia 204432|Acidobacteriia G Fructose-bisphosphate aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_1017185_3 1403313.AXBR01000021_gene3164 2.32e-35 142.0 COG0849@1|root,COG0849@2|Bacteria,1TP1Z@1239|Firmicutes,4H9NF@91061|Bacilli,1ZBH1@1386|Bacillus 91061|Bacilli D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0098552,GO:0098562 - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - DUF3484,FtsA,SHS2_FTSA k59_1017185_4 1121289.JHVL01000030_gene415 4.01e-40 143.0 COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,36F0J@31979|Clostridiaceae 186801|Clostridia D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_821148_1 1415779.JOMH01000001_gene3134 2.17e-71 223.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1S670@1236|Gammaproteobacteria,1X9PH@135614|Xanthomonadales 135614|Xanthomonadales EP Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_821148_2 502025.Hoch_0127 5.24e-30 116.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,42M3F@68525|delta/epsilon subdivisions,2WJ32@28221|Deltaproteobacteria,2YTUG@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the ABC transporter superfamily oppD - - ko:K02031,ko:K12371,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00324,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_658195_1 572480.Arnit_2056 4.32e-133 383.0 28M5D@1|root,2ZAJ6@2|Bacteria,1R9NN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_853862_1 572544.Ilyop_1201 2.58e-98 311.0 COG0248@1|root,COG0337@1|root,COG0248@2|Bacteria,COG0337@2|Bacteria,378GB@32066|Fusobacteria 32066|Fusobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 3.6.1.11,3.6.1.40,4.2.3.4 ko:K01524,ko:K01735 ko00230,ko00400,ko01100,ko01110,ko01130,ko01230,map00230,map00400,map01100,map01110,map01130,map01230 M00022 R03083,R03409 RC00002,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,Ppx-GppA k59_951923_1 180281.CPCC7001_2530 8.62e-11 69.7 COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1GN2B@1117|Cyanobacteria,22TM4@167375|Cyanobium 1117|Cyanobacteria KL Domain of unknown function (DUF3427) - - - - - - - - - - - - DUF3427 k59_135045_1 1249627.D779_0094 2.78e-63 219.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales 135613|Chromatiales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_69187_1 1048983.EL17_00375 1.66e-85 274.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia 976|Bacteroidetes G PFAM Glycosyl Hydrolase - - - - - - - - - - - - Glyco_hydro_92 k59_853863_1 572544.Ilyop_0543 1.39e-198 585.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,378RN@32066|Fusobacteria 32066|Fusobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_363497_1 1168034.FH5T_12670 6e-102 308.0 COG3291@1|root,COG3291@2|Bacteria,4NU2U@976|Bacteroidetes,2FNZM@200643|Bacteroidia 976|Bacteroidetes S C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C k59_462055_1 205922.Pfl01_1130 7.51e-26 101.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1YNI2@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_462055_2 472759.Nhal_2432 1.71e-42 146.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales 135613|Chromatiales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_919660_1 318167.Sfri_3694 8.55e-65 215.0 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,1SM5Z@1236|Gammaproteobacteria,2QBE8@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein - - - - - - - - - - - - FAD_binding_2 k59_199876_1 1169154.KB897782_gene4949 6.36e-11 68.6 COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2GJ14@201174|Actinobacteria 201174|Actinobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - P_proprotein,Peptidase_S8 k59_821162_1 338966.Ppro_0365 1.12e-19 86.7 2BXP3@1|root,2ZA5J@2|Bacteria,1R484@1224|Proteobacteria,430RZ@68525|delta/epsilon subdivisions,2WVU5@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_560013_1 1177594.MIC448_1170008 5.19e-46 163.0 COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4FKQS@85023|Microbacteriaceae 201174|Actinobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_167880_1 1197906.CAJQ02000023_gene2584 3.53e-94 293.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2TVA2@28211|Alphaproteobacteria,3JRH7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_135055_1 1121033.AUCF01000005_gene5346 2.38e-08 55.5 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWEB@28211|Alphaproteobacteria,2JYVB@204441|Rhodospirillales 204441|Rhodospirillales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_135055_3 387093.SUN_1064 9.87e-55 185.0 29Y2F@1|root,30JVD@2|Bacteria,1RAWX@1224|Proteobacteria,4300B@68525|delta/epsilon subdivisions,2YRWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_984450_1 768671.ThimaDRAFT_4427 6.93e-64 210.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,1S900@1236|Gammaproteobacteria,1WZQJ@135613|Chromatiales 135613|Chromatiales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_331169_1 1265845.PWEIH_03086 4.09e-103 309.0 COG0673@1|root,COG0673@2|Bacteria,1TRHA@1239|Firmicutes,4HA6R@91061|Bacilli,26MHV@186820|Listeriaceae 91061|Bacilli S Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively iolG - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_428540_1 1005048.CFU_0751 1.13e-79 252.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,4724E@75682|Oxalobacteraceae 28216|Betaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_527314_1 1230342.CTM_26547 9.45e-74 231.0 COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia,36W7D@31979|Clostridiaceae 186801|Clostridia G Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP) iolC - 2.7.1.4,2.7.1.92 ko:K00847,ko:K03338 ko00051,ko00500,ko00520,ko00562,ko01100,ko01120,map00051,map00500,map00520,map00562,map01100,map01120 - R00760,R00867,R03920,R05661 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_853878_1 765910.MARPU_13520 8.25e-98 293.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1WWRH@135613|Chromatiales 135613|Chromatiales G Fructose-bisphosphate aldolase, class II, Calvin cycle subtype - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_755412_1 1144325.PMI22_00812 2.61e-69 221.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RZVB@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_462071_1 882.DVU_2963 4.82e-41 139.0 COG0745@1|root,COG0745@2|Bacteria,1MZGI@1224|Proteobacteria,42UM3@68525|delta/epsilon subdivisions,2WR2K@28221|Deltaproteobacteria,2MC1R@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg k59_462071_2 272134.KB731324_gene3745 6.14e-11 65.1 COG0745@1|root,COG0784@1|root,COG1511@1|root,COG2770@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG1511@2|Bacteria,COG2770@2|Bacteria,COG5002@2|Bacteria,1GHDJ@1117|Cyanobacteria,1H8KY@1150|Oscillatoriales 1117|Cyanobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg k59_624986_1 1268237.G114_17212 1.13e-14 72.8 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1Y3IW@135624|Aeromonadales 135624|Aeromonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_624986_2 1049564.TevJSym_bu00050 0.0 2255.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1J52Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_624986_3 765910.MARPU_03680 2.99e-48 157.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,1WYGN@135613|Chromatiales 135613|Chromatiales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_624986_4 2340.JV46_16140 2.35e-87 260.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1J5V2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_792948_1 861452.HMPREF9093_00196 3.68e-133 389.0 COG0280@1|root,COG0280@2|Bacteria,378DI@32066|Fusobacteria 32066|Fusobacteria C phosphate acetyltransferase pta - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB k59_792948_2 526218.Sterm_0621 7.14e-182 518.0 COG0282@1|root,COG0282@2|Bacteria,378F4@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_792948_3 572544.Ilyop_0543 1.61e-113 356.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,378RN@32066|Fusobacteria 32066|Fusobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_174690_1 563040.Saut_1084 2.78e-57 190.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2YMHJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_174690_2 563040.Saut_1083 1.43e-118 343.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2YMZ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ABC transporter, ATP-binding protein lptB - - ko:K01990,ko:K06861 ko02010,map02010 M00254,M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1,3.A.1 - - ABC_tran,BCA_ABC_TP_C k59_991666_1 1168034.FH5T_02990 2.96e-37 129.0 COG0179@1|root,COG0179@2|Bacteria,4NGCT@976|Bacteroidetes,2FPPX@200643|Bacteroidia 976|Bacteroidetes Q FAH family fahA - - - - - - - - - - - FAA_hydrolase k59_991666_2 1168034.FH5T_03000 8.68e-80 243.0 COG0847@1|root,COG0847@2|Bacteria,4NE82@976|Bacteroidetes,2FMQF@200643|Bacteroidia 976|Bacteroidetes L DNA polymerase III dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_792953_1 1408418.JNJH01000006_gene1308 4.86e-76 238.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2JPGN@204441|Rhodospirillales 204441|Rhodospirillales S MazG nucleotide pyrophosphohydrolase domain mazG - 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - - MazG k59_338646_1 686340.Metal_1717 3.6e-81 249.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1XE2M@135618|Methylococcales 135618|Methylococcales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_958165_1 746697.Aeqsu_3219 7.3e-82 258.0 COG0642@1|root,COG2205@2|Bacteria,4NEFW@976|Bacteroidetes,1HWJQ@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase rprX - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_599390_1 1056512.D515_01231 1.05e-23 105.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1XSMI@135623|Vibrionales 135623|Vibrionales E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_958167_2 96561.Dole_2537 3.06e-64 209.0 COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,43BRU@68525|delta/epsilon subdivisions,2X72N@28221|Deltaproteobacteria,2MIN5@213118|Desulfobacterales 28221|Deltaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_434746_1 1385517.N800_13180 4.09e-43 160.0 COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_696973_1 1131451.O1K_19401 2.09e-33 118.0 COG3293@1|root,COG3293@2|Bacteria,1N3I7@1224|Proteobacteria,1SPWK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - DUF4096 k59_696973_2 686340.Metal_0008 1.82e-39 139.0 COG3293@1|root,COG3293@2|Bacteria,1R9X8@1224|Proteobacteria,1S3IC@1236|Gammaproteobacteria,1XGBB@135618|Methylococcales 135618|Methylococcales L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_827749_1 880072.Desac_2092 3.13e-91 283.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MQ5R@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_991676_1 1537917.JU82_09320 7.26e-283 818.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2YMRQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_991676_2 1537917.JU82_09315 1.93e-89 274.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2YN2P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2,Pyr_redox_3 k59_1023514_1 1260251.SPISAL_00120 6.27e-30 115.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1WW4W@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_958179_1 743299.Acife_2323 1.19e-71 229.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_926565_1 382464.ABSI01000022_gene474 2.6e-95 293.0 COG3458@1|root,COG3458@2|Bacteria,46UDN@74201|Verrucomicrobia,2IVMH@203494|Verrucomicrobiae 203494|Verrucomicrobiae Q Acetyl xylan esterase (AXE1) - - - - - - - - - - - - AXE1 k59_728864_1 563040.Saut_0144 2.93e-86 271.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,42MHW@68525|delta/epsilon subdivisions,2YNJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_207176_1 870187.Thini_2281 4.32e-14 70.9 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,4624S@72273|Thiotrichales 72273|Thiotrichales C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_207176_2 1469245.JFBG01000007_gene672 3.89e-57 182.0 COG1142@1|root,COG1142@2|Bacteria,1MUHW@1224|Proteobacteria,1RQWU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Formate hydrogenlyase hyfA - - ko:K12136,ko:K15827 - - - - ko00000,ko01000 - - iAF1260.b2724,iBWG_1329.BWG_2460,iE2348C_1286.E2348C_2989,iEC042_1314.EC042_2918,iECABU_c1320.ECABU_c29950,iECDH10B_1368.ECDH10B_2892,iECDH1ME8569_1439.ECDH1ME8569_2634,iECED1_1282.ECED1_3175,iECO111_1330.ECO111_3444,iECO26_1355.ECO26_3789,iECP_1309.ECP_2687,iECUMN_1333.ECUMN_3046,iETEC_1333.ETEC_2915,iEcDH1_1363.EcDH1_0965,iEcHS_1320.EcHS_A2860,iEcSMS35_1347.EcSMS35_2849,iEcolC_1368.EcolC_0988,iEcolC_1368.EcolC_1195,iJO1366.b2724,iJR904.b2724,iSFV_1184.SFV_2779,iSSON_1240.SSON_2871,iUMNK88_1353.UMNK88_3076,iUMNK88_1353.UMNK88_3397,iY75_1357.Y75_RS14175,ic_1306.c3284 Fer4,Fer4_3,Fer4_4,Fer4_6,Fer4_7,Fer4_9 k59_566811_1 997884.HMPREF1068_03744 1.15e-168 509.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FW53@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_665153_1 1168034.FH5T_11560 2.2e-57 196.0 COG0768@1|root,COG0768@2|Bacteria,4NE47@976|Bacteroidetes,2FM4X@200643|Bacteroidia 976|Bacteroidetes M penicillin-binding protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_665153_2 1168034.FH5T_11565 5.3e-92 286.0 COG0772@1|root,COG0772@2|Bacteria,4NDZD@976|Bacteroidetes,2FNA1@200643|Bacteroidia 976|Bacteroidetes D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_728866_1 331678.Cphamn1_0514 3.82e-39 154.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - HemolysinCabind k59_6803_1 526222.Desal_2697 5.42e-60 200.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria,2M9FR@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_566833_1 319224.Sputcn32_3416 3.93e-42 157.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,2Q99F@267890|Shewanellaceae 1236|Gammaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceF GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_0111,iSSON_1240.SSON_0123,iYL1228.KPN_00119 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_991707_1 32057.KB217478_gene5809 1.72e-27 102.0 COG4115@1|root,COG4115@2|Bacteria,1G82H@1117|Cyanobacteria,1HU1B@1161|Nostocales 1117|Cyanobacteria S YoeB-like toxin of bacterial type II toxin-antitoxin system - - - ko:K19158 - - - - ko00000,ko01000,ko02048 - - - YoeB_toxin k59_827781_1 1232410.KI421412_gene355 5.62e-128 384.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria 1224|Proteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_2,TPR_8 k59_239444_1 1123517.JOMR01000001_gene272 7.45e-29 122.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,4608A@72273|Thiotrichales 72273|Thiotrichales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg k59_239444_2 1565314.OA34_02270 5.6e-17 77.4 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42PQP@68525|delta/epsilon subdivisions,2YNQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein ybbA - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_338698_1 522306.CAP2UW1_4007 1.87e-43 160.0 COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria 1224|Proteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_41949_1 1096930.L284_17825 4.99e-38 142.0 COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,2U0Y8@28211|Alphaproteobacteria,2K1SN@204457|Sphingomonadales 204457|Sphingomonadales L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_501862_1 1379281.AVAG01000043_gene294 5.71e-29 113.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria,2M8GP@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_76416_1 4572.TRIUR3_00082-P1 7.96e-231 644.0 COG0056@1|root,KOG1353@2759|Eukaryota,37JWW@33090|Viridiplantae,3G9FP@35493|Streptophyta 35493|Streptophyta C ATP synthase subunit alpha atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_C,ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_109294_1 1168034.FH5T_18930 3.74e-111 330.0 COG0508@1|root,COG0508@2|Bacteria,4NED0@976|Bacteroidetes,2FNQF@200643|Bacteroidia 976|Bacteroidetes C COG COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes bfmBB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_697029_1 204669.Acid345_3781 1.03e-41 154.0 COG1132@1|root,COG1132@2|Bacteria,3Y2Y9@57723|Acidobacteria,2JI79@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_697029_2 994479.GL877878_gene3613 6.84e-08 59.3 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DYBT@85010|Pseudonocardiales 201174|Actinobacteria L Tyrosine recombinase XerD xerD GO:0008150,GO:0040007 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_434801_1 1408473.JHXO01000004_gene97 9.76e-109 324.0 COG1979@1|root,COG1979@2|Bacteria,4NF1D@976|Bacteroidetes,2FPAW@200643|Bacteroidia 976|Bacteroidetes C alcohol dehydrogenase yqhD - - ko:K08325 ko00640,map00640 - R02528 RC00739 ko00000,ko00001,ko01000 - - - Fe-ADH k59_109297_1 83406.HDN1F_05290 4.65e-104 321.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1J5I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0405 Gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_991722_1 1122603.ATVI01000005_gene3347 1.13e-89 287.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1X31T@135614|Xanthomonadales 135614|Xanthomonadales OU signal peptide peptidase sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_926617_1 864702.OsccyDRAFT_2410 6.54e-81 263.0 COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria,1H71S@1150|Oscillatoriales 1117|Cyanobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_501877_1 272563.CD630_36520 1.23e-51 180.0 COG0308@1|root,COG0308@2|Bacteria,1U6PC@1239|Firmicutes,24AYS@186801|Clostridia,25QI4@186804|Peptostreptococcaceae 186801|Clostridia E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_793001_2 997884.HMPREF1068_00682 4.47e-48 168.0 COG3876@1|root,COG3876@2|Bacteria,4NIY6@976|Bacteroidetes,2FM36@200643|Bacteroidia,4AMBR@815|Bacteroidaceae 976|Bacteroidetes S Protein of unknown function (DUF1343) - - - - - - - - - - - - Amidase_2,DUF1343 k59_893098_1 1528106.JRJE01000031_gene3421 2.38e-84 255.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,2JZN8@204441|Rhodospirillales 204441|Rhodospirillales L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_632147_1 985665.HPL003_03670 4.7e-07 52.8 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,26TDT@186822|Paenibacillaceae 91061|Bacilli K Belongs to the sigma-70 factor family. ECF subfamily sigW - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_728903_1 1235797.C816_04292 1.08e-29 121.0 2ETSK@1|root,33MA0@2|Bacteria,1VN3Q@1239|Firmicutes,25533@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_761868_1 1121403.AUCV01000093_gene2575 7.12e-62 203.0 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,42VCD@68525|delta/epsilon subdivisions,2WRUC@28221|Deltaproteobacteria,2MMEZ@213118|Desulfobacterales 28221|Deltaproteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32,rve k59_434814_1 929558.SMGD1_0921 1.31e-115 350.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2YMEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_697041_2 305700.B447_07307 1.42e-104 311.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,2KVIA@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_468488_1 1366050.N234_36085 2.7e-118 349.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1K2WH@119060|Burkholderiaceae 28216|Betaproteobacteria L Elements of external origin - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_32 k59_728907_1 502025.Hoch_6478 1.7e-27 116.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42QTE@68525|delta/epsilon subdivisions,2WN61@28221|Deltaproteobacteria,2YUPI@29|Myxococcales 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_23,rve k59_142594_1 236097.ADG881_43 4.76e-22 94.7 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1XIRK@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the GMC oxidoreductase family - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_142594_2 1122185.N792_06685 2.99e-42 154.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1X3VD@135614|Xanthomonadales 135614|Xanthomonadales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_728908_1 1249627.D779_1449 3.13e-24 100.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WWB0@135613|Chromatiales 135613|Chromatiales S PFAM von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_728908_2 196490.AUEZ01000028_gene1942 4.17e-19 83.6 COG2304@1|root,COG2304@2|Bacteria,1PXSC@1224|Proteobacteria,2UFIR@28211|Alphaproteobacteria,3K008@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4381) - - - - - - - - - - - - DUF4381 k59_958239_1 1537917.JU82_08350 0.0 1089.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2YMS4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_239486_1 572544.Ilyop_0261 6.08e-75 229.0 COG1799@1|root,COG1799@2|Bacteria,37AJN@32066|Fusobacteria 32066|Fusobacteria D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA - - - ko:K09772 - - - - ko00000,ko03036 - - - SepF k59_665213_1 1049564.TevJSym_bd00050 6.68e-38 134.0 COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Cytochrome C fccA GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K17230 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001 - - - Cytochrome_CBB3 k59_697047_1 1172190.M947_02290 1.95e-16 79.0 COG0457@1|root,COG0457@2|Bacteria,1Q55C@1224|Proteobacteria,42RCA@68525|delta/epsilon subdivisions,2YND3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S chaperone-mediated protein folding - - - - - - - - - - - - PPR k59_697047_2 1249480.B649_03815 1.15e-67 211.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2YM8T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the TrpC family trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_303873_1 29581.BW37_03083 3.96e-07 57.8 COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,2WBJ5@28216|Betaproteobacteria,475Y1@75682|Oxalobacteraceae 28216|Betaproteobacteria M TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_991751_1 1123073.KB899245_gene9 2.45e-152 471.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales 135614|Xanthomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_827824_1 929558.SMGD1_1935 3.32e-119 346.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2YMI2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - ko:K02034,ko:K12370 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_271744_34 351348.Maqu_2894 3.74e-106 337.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,4668G@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_271744_35 1049564.TevJSym_ab01040 8.75e-314 879.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1J4DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_894011_1 1244869.H261_18767 3.04e-52 177.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,2JPI1@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_240207_3 519989.ECTPHS_05671 1.29e-49 170.0 COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,1S8SQ@1236|Gammaproteobacteria,1WY0I@135613|Chromatiales 135613|Chromatiales N Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly - - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA k59_240207_4 1117647.M5M_02195 9.09e-124 364.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,1RPS1@1236|Gammaproteobacteria,1J4FK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0835 Chemotaxis signal transduction protein cheV - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_240207_5 754477.Q7C_2278 4.89e-76 239.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria,461ZM@72273|Thiotrichales 72273|Thiotrichales NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_933374_1 314254.OA2633_05671 6.3e-41 150.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria,43Z1B@69657|Hyphomonadaceae 28211|Alphaproteobacteria Q Amidohydrolase family MA20_04810 - 3.5.1.82 ko:K01461 - - - - ko00000,ko01000 - - - Amidohydro_3 k59_933374_2 384765.SIAM614_02581 4.58e-26 107.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_377202_2 1123401.JHYQ01000010_gene2438 7.43e-57 219.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria 1224|Proteobacteria M TIGRFAM YD repeat protein - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_377202_4 82654.Pse7367_2629 2.8e-15 89.7 COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,1G4PY@1117|Cyanobacteria,1HEZB@1150|Oscillatoriales 1117|Cyanobacteria M domain, Protein - - - - - - - - - - - - RHS_repeat k59_965478_1 1479237.JMLY01000001_gene1375 7.25e-61 196.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_573634_2 1121033.AUCF01000014_gene1264 6.13e-52 174.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,2JR23@204441|Rhodospirillales 204441|Rhodospirillales E branched-chain amino acid transport - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_998723_1 1168034.FH5T_01595 1.47e-137 400.0 COG1520@1|root,COG1520@2|Bacteria,4P28I@976|Bacteroidetes,2FX0J@200643|Bacteroidia 976|Bacteroidetes S PQQ-like domain - - - - - - - - - - - - PQQ_2 k59_474781_1 1123377.AUIV01000002_gene1206 3.99e-46 172.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1X3A2@135614|Xanthomonadales 135614|Xanthomonadales P COG0474 Cation transport ATPase - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_900124_1 96561.Dole_2741 1.72e-54 175.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2MJTB@213118|Desulfobacterales 28221|Deltaproteobacteria F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_115840_2 1049564.TevJSym_af00380 9.23e-13 67.0 COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,1S2CW@1236|Gammaproteobacteria,1J5X8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) ybfF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0016790,GO:0044424,GO:0044444,GO:0044464,GO:0052689 - ko:K01175 - - - - ko00000,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_573642_1 879212.DespoDRAFT_03383 1.3e-25 111.0 COG4783@1|root,COG4783@2|Bacteria,1QTUQ@1224|Proteobacteria,43CMK@68525|delta/epsilon subdivisions,2X8EH@28221|Deltaproteobacteria,2MPP1@213118|Desulfobacterales 28221|Deltaproteobacteria S Oxygen tolerance - - - - - - - - - - - - BatD k59_704106_1 697282.Mettu_3992 1.15e-54 187.0 COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,1T549@1236|Gammaproteobacteria,1XH1Q@135618|Methylococcales 135618|Methylococcales L Transposase DDE domain - - - - - - - - - - - - DUF772 k59_900131_1 207954.MED92_05308 1.11e-12 73.6 COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,1T1GK@1236|Gammaproteobacteria,1XHZ0@135619|Oceanospirillales 135619|Oceanospirillales P ABC transporter permease - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_474796_2 349124.Hhal_0705 2.13e-78 239.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1WW1Q@135613|Chromatiales 135613|Chromatiales S Belongs to the WrbA family - - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_377228_1 1396858.Q666_05800 1.47e-97 315.0 COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,1RPTX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - AAA_29,SbcCD_C k59_900140_2 1205753.A989_18120 5.06e-25 102.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1X3SU@135614|Xanthomonadales 135614|Xanthomonadales K Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_277421_1 1168034.FH5T_10135 9.64e-114 354.0 COG0038@1|root,COG0038@2|Bacteria,4NZYS@976|Bacteroidetes,2G0DB@200643|Bacteroidia 976|Bacteroidetes P Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 k59_377229_1 305700.B447_07799 1.95e-17 89.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,2KUFQ@206389|Rhodocyclales 206389|Rhodocyclales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 k59_474807_2 102129.Lepto7375DRAFT_4927 4.56e-08 52.8 2B3PJ@1|root,31WD1@2|Bacteria,1G6XS@1117|Cyanobacteria,1HD98@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_409586_2 563040.Saut_0003 1.31e-57 196.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2YMUW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_310971_1 196490.AUEZ01000005_gene3531 5.02e-20 94.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JUJC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_834698_1 399739.Pmen_4084 1.76e-45 157.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1YDMG@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858 AAA_26 k59_900151_1 326298.Suden_0070 7.65e-113 338.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2YN8R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_149476_1 1226325.HMPREF1548_06300 8.76e-12 72.0 COG1609@1|root,COG1609@2|Bacteria,1TSRM@1239|Firmicutes,24BFS@186801|Clostridia,36GJQ@31979|Clostridiaceae 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_4 k59_48456_1 1410608.JNKX01000027_gene2722 2.49e-51 171.0 COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,2FMCZ@200643|Bacteroidia,4AN6P@815|Bacteroidaceae 976|Bacteroidetes S hydrolase, carbon-nitrogen family pabB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_48456_2 1168034.FH5T_05995 1.05e-140 405.0 COG2957@1|root,COG2957@2|Bacteria,4NGF8@976|Bacteroidetes,2FMQH@200643|Bacteroidia 976|Bacteroidetes E Belongs to the agmatine deiminase family aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_672406_2 438753.AZC_4442 9.46e-58 193.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,3EYIZ@335928|Xanthobacteraceae 28211|Alphaproteobacteria E Glutamine synthetase, catalytic domain glnA1 - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_704125_1 439235.Dalk_4908 1.49e-80 251.0 COG0407@1|root,COG0407@2|Bacteria,1R9IN@1224|Proteobacteria,42Q1Q@68525|delta/epsilon subdivisions,2WMDE@28221|Deltaproteobacteria,2MPE9@213118|Desulfobacterales 28221|Deltaproteobacteria H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D k59_277439_1 765913.ThidrDRAFT_2491 5.53e-110 337.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales 135613|Chromatiales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_214650_1 1325130.HFN_0767 1.57e-14 77.4 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2YM9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_377919_1 1485545.JQLW01000005_gene1068 2.82e-39 149.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria 1224|Proteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD4 - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_150224_1 1537917.JU82_04055 2.69e-20 87.8 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2YMPY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_150224_2 563040.Saut_1607 1.21e-141 416.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2YMAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_542072_1 1453501.JELR01000001_gene2703 2.22e-160 480.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,465T2@72275|Alteromonadaceae 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_999520_1 1165841.SULAR_09079 4.37e-78 241.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,42N54@68525|delta/epsilon subdivisions,2YNS5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_475508_1 1437605.BACT_1269 1.16e-13 75.1 COG5184@1|root,COG5184@2|Bacteria,2IG31@201174|Actinobacteria,4D0NM@85004|Bifidobacteriales 201174|Actinobacteria DZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - Big_3_5,Pkinase,RCC1 k59_150228_1 1116472.MGMO_83c00220 7.46e-37 141.0 COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria 1224|Proteobacteria S Lipase maturation factor - - - - - - - - - - - - DUF393,LMF1 k59_934079_1 1235802.C823_05409 2.64e-87 273.0 COG1321@1|root,COG1321@2|Bacteria,1UZX6@1239|Firmicutes,248DA@186801|Clostridia 186801|Clostridia K iron dependent repressor - - - - - - - - - - - - - k59_150249_2 1116472.MGMO_66c00350 9.4e-09 54.7 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,1XFB0@135618|Methylococcales 135618|Methylococcales J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_542084_2 1172190.M947_05355 1.1e-24 98.2 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,42MIP@68525|delta/epsilon subdivisions,2YMPW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_704874_2 1123054.KB907730_gene2553 1.43e-06 52.8 COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria 1236|Gammaproteobacteria D cellulase activity - - - - - - - - - - - - - k59_607414_1 377629.TERTU_0850 3.85e-49 172.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,2PMKD@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G MFS/sugar transport protein ynaJ - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_900851_2 929558.SMGD1_0383 4.08e-41 143.0 COG1413@1|root,COG1413@2|Bacteria,1RIZR@1224|Proteobacteria 1224|Proteobacteria C HEAT repeats - - - - - - - - - - - - HEAT_2 k59_377948_1 1408473.JHXO01000007_gene735 3.51e-66 215.0 COG1148@1|root,COG1148@2|Bacteria,4NI95@976|Bacteroidetes,2FRRV@200643|Bacteroidia 976|Bacteroidetes C NAD(P)-binding Rossmann-like domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Fer4,Fer4_7,HI0933_like,Pyr_redox_2 k59_246981_2 1168034.FH5T_10235 4.74e-153 432.0 COG1117@1|root,COG1117@2|Bacteria,4NFAB@976|Bacteroidetes,2FMN7@200643|Bacteroidia 976|Bacteroidetes P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_934091_1 887062.HGR_05459 2.69e-151 437.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VJ00@28216|Betaproteobacteria,4AC6Q@80864|Comamonadaceae 28216|Betaproteobacteria M Cyclopropane-fatty-acyl-phospholipid synthase cfa GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_442376_1 283942.IL2076 1.92e-17 85.1 COG0664@1|root,COG0664@2|Bacteria,1RB72@1224|Proteobacteria,1S22E@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - cNMP_binding k59_49149_2 387093.SUN_1010 5.88e-39 140.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2YN4M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0283 DHQ_synthase k59_574452_1 1123517.JOMR01000001_gene846 1.4e-69 216.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,4600Q@72273|Thiotrichales 72273|Thiotrichales O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_246991_1 1168034.FH5T_08625 9.46e-59 197.0 COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,2FM67@200643|Bacteroidia 976|Bacteroidetes C SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_246991_2 1168289.AJKI01000002_gene2610 5.15e-14 71.2 2CAZH@1|root,2Z7RU@2|Bacteria,4NGM5@976|Bacteroidetes,2FM2S@200643|Bacteroidia,3XJW8@558415|Marinilabiliaceae 976|Bacteroidetes S Succinate dehydrogenase cytochrome B subunit, b558 family sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_640007_1 997346.HMPREF9374_1794 1.32e-112 340.0 COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,4HA0U@91061|Bacilli,27BNF@186824|Thermoactinomycetaceae 91061|Bacilli G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 k59_934110_1 913325.N799_12070 3.32e-92 280.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1X3U9@135614|Xanthomonadales 135614|Xanthomonadales K RNA polymerase sigma factor RpoH rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_150268_1 1370122.JHXQ01000011_gene1426 4.33e-14 72.4 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria,4B91H@82115|Rhizobiaceae 28211|Alphaproteobacteria L Belongs to the DNA photolyase family phrB GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_150268_3 1165096.ARWF01000001_gene237 2.23e-134 392.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VMFC@28216|Betaproteobacteria,2KKMK@206350|Nitrosomonadales 206350|Nitrosomonadales I Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_966314_1 335543.Sfum_2557 2.85e-57 202.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WJYB@28221|Deltaproteobacteria,2MQNK@213462|Syntrophobacterales 28221|Deltaproteobacteria NU Neisseria PilC beta-propeller domain - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_934122_1 1276756.AUEX01000046_gene3146 1.24e-57 189.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VPKC@28216|Betaproteobacteria,4AJ1Y@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short_C2 k59_966315_1 1249480.B649_00570 9.62e-14 69.7 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2YMH9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_966315_2 1537917.JU82_00250 2.21e-114 337.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2YMCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kpsF - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_966319_1 38033.XP_001225279.1 1.24e-06 52.8 2EBRV@1|root,2SHSP@2759|Eukaryota,38BZE@33154|Opisthokonta,3NZF9@4751|Fungi,3QTNJ@4890|Ascomycota,21490@147550|Sordariomycetes,3UBA0@5139|Sordariales 4751|Fungi - - - - - - - - - - - - - - - k59_1030971_3 1121403.AUCV01000028_gene2455 1.75e-21 87.4 COG0346@1|root,COG0346@2|Bacteria,1Q07V@1224|Proteobacteria,436F0@68525|delta/epsilon subdivisions,2WWDR@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_247023_2 1168034.FH5T_12550 1.32e-16 76.6 COG0745@1|root,COG0745@2|Bacteria,4NF1I@976|Bacteroidetes,2FNZV@200643|Bacteroidia 976|Bacteroidetes K transcriptional regulatory protein - - - - - - - - - - - - Response_reg,Trans_reg_C k59_311732_2 1283300.ATXB01000001_gene1470 3.83e-69 213.0 COG1051@1|root,COG1051@2|Bacteria,1MWNH@1224|Proteobacteria,1S56W@1236|Gammaproteobacteria,1XF4J@135618|Methylococcales 135618|Methylococcales F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_215385_1 1347342.BN863_23700 3.22e-61 197.0 COG4105@1|root,COG4105@2|Bacteria,4NJ5A@976|Bacteroidetes,1HYEQ@117743|Flavobacteriia 976|Bacteroidetes S Outer membrane assembly lipoprotein YfiO yfiO - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_215385_2 504487.JCM19302_195 8.23e-58 180.0 2CT4B@1|root,32SSJ@2|Bacteria,4NQ76@976|Bacteroidetes,1I2X0@117743|Flavobacteriia 976|Bacteroidetes S Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - - - - - - - - - - - RNA_pol_Rpb6 k59_934130_1 1122604.JONR01000010_gene3929 6.41e-66 220.0 COG1752@1|root,COG1752@2|Bacteria,1N5SK@1224|Proteobacteria,1RSDG@1236|Gammaproteobacteria,1X5Q9@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF3336) - - - - - - - - - - - - DUF3336,Patatin k59_574479_1 572544.Ilyop_0867 7.68e-205 583.0 COG0728@1|root,COG0728@2|Bacteria,3789R@32066|Fusobacteria 32066|Fusobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_574479_2 572544.Ilyop_0868 1.72e-29 117.0 COG0827@1|root,COG0827@2|Bacteria,379CB@32066|Fusobacteria 32066|Fusobacteria L TaqI-like C-terminal specificity domain - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - Eco57I,Methyltransf_31,TaqI_C k59_286445_1 264732.Moth_2314 1.79e-36 141.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase sfrB - 1.17.1.10,1.17.1.9,1.97.1.9 ko:K00123,ko:K12527,ko:K15022 ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519,R07229 RC02420,RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_354243_1 1331060.RLDS_11430 3.05e-57 188.0 2ETRR@1|root,33M97@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_354243_2 1121405.dsmv_1780 2.85e-18 82.8 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,42SZ0@68525|delta/epsilon subdivisions,2WPIR@28221|Deltaproteobacteria,2MJ2E@213118|Desulfobacterales 28221|Deltaproteobacteria L helicase - - - - - - - - - - - - Helicase_C,SNF2_N k59_518733_1 483215.BACFIN_07076 2.21e-37 135.0 COG1218@1|root,COG1218@2|Bacteria,4NFHY@976|Bacteroidetes,2FP00@200643|Bacteroidia,4AMGH@815|Bacteroidaceae 976|Bacteroidetes P 3'(2'),5'-bisphosphate nucleotidase cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_681145_1 96561.Dole_1498 5.02e-37 131.0 COG2050@1|root,COG2050@2|Bacteria,1NGFY@1224|Proteobacteria,42UY5@68525|delta/epsilon subdivisions,2WQPB@28221|Deltaproteobacteria,2MJUJ@213118|Desulfobacterales 28221|Deltaproteobacteria Q PFAM thioesterase superfamily - - - ko:K02614 ko00360,map00360 - R09840 RC00004,RC00014 ko00000,ko00001,ko01000 - - - 4HBT k59_417915_1 1033802.SSPSH_000052 1.03e-74 236.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_190917_1 1463821.JOGR01000010_gene3758 2.12e-93 298.0 COG3266@1|root,COG3866@1|root,COG3266@2|Bacteria,COG3866@2|Bacteria,2GNKW@201174|Actinobacteria,4EZ6V@85014|Glycomycetales 201174|Actinobacteria G Pectate lyase - - - - - - - - - - - - Pec_lyase_C k59_518742_1 246194.CHY_0560 9.91e-90 282.0 COG0492@1|root,COG3118@1|root,COG0492@2|Bacteria,COG3118@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,42I3F@68295|Thermoanaerobacterales 186801|Clostridia C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Thioredoxin k59_942105_1 1338011.BD94_3732 4.57e-56 189.0 COG0517@1|root,COG0517@2|Bacteria,4NHKP@976|Bacteroidetes,1HYR8@117743|Flavobacteriia 976|Bacteroidetes S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_451272_1 469616.FMAG_02460 2.54e-103 312.0 COG1477@1|root,COG1477@2|Bacteria,3788Y@32066|Fusobacteria 32066|Fusobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_451272_2 572544.Ilyop_0186 1.15e-200 577.0 COG3808@1|root,COG3808@2|Bacteria,3795I@32066|Fusobacteria 32066|Fusobacteria C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_744061_1 240015.ACP_1328 3.69e-52 173.0 COG2801@1|root,COG2801@2|Bacteria,3Y7AG@57723|Acidobacteria,2JKC5@204432|Acidobacteriia 204432|Acidobacteriia L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_32,rve,rve_3 k59_744061_2 240015.ACP_1548 1.76e-05 43.9 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve_3 k59_778056_1 1123518.ARWI01000001_gene2152 8.32e-68 219.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,4606I@72273|Thiotrichales 72273|Thiotrichales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_843128_1 706587.Desti_3757 2.53e-156 454.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,2MQSJ@213462|Syntrophobacterales 28221|Deltaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2,4.3.1.1 ko:K01679,ko:K01744 ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R00490,R01082 RC00316,RC00443,RC02799 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_451278_1 864051.BurJ1DRAFT_0531 1.88e-46 156.0 COG2010@1|root,COG2010@2|Bacteria,1REKI@1224|Proteobacteria 1224|Proteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_354260_1 472759.Nhal_0685 1.19e-18 82.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1WWPE@135613|Chromatiales 135613|Chromatiales G HAD-superfamily hydrolase, subfamily IA, variant 3 gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_354260_2 1266914.ATUK01000014_gene2111 1.16e-74 238.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales 135613|Chromatiales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_712838_2 563040.Saut_0195 1.08e-170 478.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2YMUY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_223272_1 439235.Dalk_0606 1.14e-117 350.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria,2MHXY@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_8 k59_92204_1 631362.Thi970DRAFT_03487 5.36e-63 201.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1WY9P@135613|Chromatiales 135613|Chromatiales F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_92204_2 521674.Plim_1467 7.34e-16 76.3 COG5361@1|root,COG5361@2|Bacteria,2IZB8@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254,Neur_chan_LBD,Neur_chan_memb k59_681164_1 518766.Rmar_0611 1.68e-74 229.0 COG1376@1|root,COG1376@2|Bacteria,4P35B@976|Bacteroidetes 976|Bacteroidetes S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_386645_1 1294265.JCM21738_5576 6.03e-30 117.0 COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,1ZBJW@1386|Bacillus 91061|Bacilli L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_386645_2 385682.AFSL01000088_gene852 8.52e-21 92.0 COG3547@1|root,COG3547@2|Bacteria,4NJ8G@976|Bacteroidetes,2FRWC@200643|Bacteroidia 976|Bacteroidetes L COG COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_974056_1 646529.Desaci_1066 1.28e-74 238.0 COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,24AES@186801|Clostridia,260Y9@186807|Peptococcaceae 186801|Clostridia Q Aromatic ring hydroxylase - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_843136_1 709032.Sulku_2348 6.69e-13 62.8 COG4736@1|root,COG4736@2|Bacteria,1QDIU@1224|Proteobacteria,42V2T@68525|delta/epsilon subdivisions,2YQ9S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O cytochrome c oxidase ccoQ - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_843136_2 1537917.JU82_02120 9.4e-90 268.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,42NZG@68525|delta/epsilon subdivisions,2YMBE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cytochrome c oxidase, cbb3-type, subunit II ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - iIT341.HP0145 FixO k59_744077_1 338966.Ppro_0819 1.52e-112 331.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WIYY@28221|Deltaproteobacteria,43T4N@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM ATPase associated with various cellular activities, AAA_3 - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_648232_1 1172190.M947_10605 7e-163 477.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2YMTD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the FtsK SpoIIIE SftA family ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1039545_1 1168034.FH5T_04080 1.73e-86 281.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FM37@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_319260_1 1195236.CTER_4148 1.3e-50 174.0 COG1879@1|root,COG1879@2|Bacteria,1UZZW@1239|Firmicutes,24BEX@186801|Clostridia,3WQK9@541000|Ruminococcaceae 186801|Clostridia G ABC-type sugar transport system, periplasmic component - - - ko:K10537 ko02010,map02010 M00213 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.2 - - Peripla_BP_4 k59_386661_1 1168034.FH5T_17390 7.01e-111 327.0 COG0639@1|root,COG0639@2|Bacteria,4NIDG@976|Bacteroidetes,2FWN0@200643|Bacteroidia 976|Bacteroidetes T Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_286522_1 1304865.JAGF01000001_gene3688 6.78e-81 252.0 COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4F0SI@85016|Cellulomonadaceae 201174|Actinobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_712864_1 1319815.HMPREF0202_00065 3.89e-154 465.0 COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3784G@32066|Fusobacteria 32066|Fusobacteria I acyl carrier protein - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,Acyltransferase,PP-binding k59_255101_1 1095769.CAHF01000025_gene622 3.24e-42 141.0 2E8C6@1|root,332QU@2|Bacteria,1NBRE@1224|Proteobacteria,2VVRG@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_124943_1 387093.SUN_0063 9.69e-102 303.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2YMD9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_615427_1 572544.Ilyop_0046 2.1e-52 170.0 COG0454@1|root,COG0456@2|Bacteria,37AF8@32066|Fusobacteria 32066|Fusobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_190947_1 8010.XP_010887588.1 1.18e-07 65.1 KOG3594@1|root,KOG3594@2759|Eukaryota,39VWA@33154|Opisthokonta,3BE2Q@33208|Metazoa,3D0K7@33213|Bilateria,48C4D@7711|Chordata,49A44@7742|Vertebrata,4A8VX@7898|Actinopterygii 33208|Metazoa S Cadherin repeats. - - - - - - - - - - - - Cadherin k59_518804_1 96561.Dole_0237 7.89e-89 287.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2MIQM@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_807307_2 472759.Nhal_3177 2.94e-16 78.2 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_92253_1 634176.NT05HA_0647 4e-12 69.7 COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1MVUT@1224|Proteobacteria,1RQB3@1236|Gammaproteobacteria,1Y72D@135625|Pasteurellales 135625|Pasteurellales E Protein involved in binding, catalytic activity, chorismate mutase activity, oxidoreductase activity, prephenate dehydrogenase (NADP ) activity, prephenate dehydrogenase activity, chorismate metabolic process, metabolic process, oxidation-reduction process and tyrosine biosynthetic process tyrA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,5.4.99.5 ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R01715,R01728 RC00125,RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,PDH k59_908663_1 1122137.AQXF01000001_gene3093 5.54e-50 175.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase, M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_21692_1 1458275.AZ34_07565 8.38e-63 203.0 COG0789@1|root,COG0789@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,4ACBQ@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein, MerR - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_648279_1 555778.Hneap_1461 1.52e-28 110.0 COG0664@1|root,COG0664@2|Bacteria,1RC7W@1224|Proteobacteria,1S2ZD@1236|Gammaproteobacteria,1WY6E@135613|Chromatiales 135613|Chromatiales T PFAM Cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding k59_518827_1 314345.SPV1_07004 1.4e-94 310.0 COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria 1224|Proteobacteria G Pyruvate phosphate dikinase - - - - - - - - - - - - LTD,PPDK_N k59_1007299_2 629265.PMA4326_23971 9.54e-05 44.3 2FK9B@1|root,34BWZ@2|Bacteria,1P202@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_124976_1 694427.Palpr_1869 4.05e-53 183.0 COG0544@1|root,COG0544@2|Bacteria,4NE99@976|Bacteroidetes,2FM7B@200643|Bacteroidia,22WV0@171551|Porphyromonadaceae 976|Bacteroidetes O Trigger factor tig - - ko:K03545 - - - - ko00000 - - - Trigger_C,Trigger_N k59_124976_2 1168034.FH5T_09510 1.89e-14 71.6 COG0583@1|root,COG0583@2|Bacteria,4NGZ5@976|Bacteroidetes,2FNH6@200643|Bacteroidia 976|Bacteroidetes K LysR substrate binding domain protein oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_92262_1 76114.ebA7003 2.79e-107 328.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria,2KUPD@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_159153_1 1265502.KB905948_gene996 1.32e-73 229.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHEF@28216|Betaproteobacteria,4ABQ2@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_223354_1 1005048.CFU_0250 5.44e-148 471.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,473K1@75682|Oxalobacteraceae 28216|Betaproteobacteria Q Linear gramicidin synthase subunit - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_354315_1 1150864.MILUP08_46621 3.37e-54 183.0 COG3642@1|root,COG3642@2|Bacteria,2GIX0@201174|Actinobacteria,4D9BS@85008|Micromonosporales 201174|Actinobacteria T Domain of unknown function (DUF4032) - - - - - - - - - - - - DUF4032,Kdo k59_681212_1 443144.GM21_0306 3.44e-22 97.8 COG2203@1|root,COG4251@1|root,COG2203@2|Bacteria,COG4251@2|Bacteria 2|Bacteria T photoreceptor activity - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - GAF,GAF_2,GerE,HATPase_c,HD,HD_5,HisKA,PAS_4,PAS_9,Response_reg k59_648301_1 1049564.TevJSym_aq00440 1.57e-16 78.2 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_648301_2 1049564.TevJSym_aq00430 2.24e-46 155.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1J6DN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 OSCP k59_223362_1 1250278.JQNQ01000001_gene393 2.62e-63 199.0 COG0742@1|root,COG0742@2|Bacteria,4NM7J@976|Bacteroidetes,1I185@117743|Flavobacteriia 976|Bacteroidetes L Methyltransferase rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_92276_1 1335757.SPICUR_00320 1.38e-33 121.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1WWF1@135613|Chromatiales 135613|Chromatiales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_92276_2 1042375.AFPL01000043_gene1333 5.13e-69 215.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,464AA@72275|Alteromonadaceae 1236|Gammaproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16,5.3.1.24 ko:K01814,ko:K01817 ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230 M00023,M00026 R03509,R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_843217_1 34506.g2107 4e-81 272.0 COG0030@1|root,KOG0820@2759|Eukaryota 2759|Eukaryota J rRNA (adenine-N6,N6-)-dimethyltransferase activity TFB2M GO:0000154,GO:0000179,GO:0000959,GO:0001510,GO:0003674,GO:0003712,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006364,GO:0006390,GO:0006391,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009058,GO:0009059,GO:0009295,GO:0009451,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022613,GO:0031167,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031974,GO:0032259,GO:0032774,GO:0034470,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042254,GO:0042645,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097659,GO:0140053,GO:0140098,GO:0140102,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.1.1.183 ko:K14191,ko:K17653 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009,ko03029 - - - RrnaAD k59_615488_1 395495.Lcho_1552 1.44e-44 161.0 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1KKAY@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Cytochrome c-type biogenesis protein cycH - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_908692_1 1168034.FH5T_07280 9.18e-87 272.0 28HG4@1|root,2Z7S0@2|Bacteria,4NE3G@976|Bacteroidetes,2FNU8@200643|Bacteroidia 976|Bacteroidetes S Gliding motility-associated protein GldM gldM - - - - - - - - - - - GldM_C,GldM_N k59_712941_1 563040.Saut_1811 4.56e-126 365.0 COG1387@1|root,COG1387@2|Bacteria,1RCEG@1224|Proteobacteria,42MIM@68525|delta/epsilon subdivisions,2YMFF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E histidinol phosphate phosphatase hisJ - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP,PHP_C k59_712941_2 1249480.B649_10365 2.64e-05 45.1 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2YNCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_974111_1 95619.PM1_0226535 5.65e-56 202.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_418010_1 1283300.ATXB01000001_gene752 1.11e-116 348.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1XE4Y@135618|Methylococcales 135618|Methylococcales C Glutamate synthase, NADH NADPH, small subunit gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_190977_1 335541.Swol_2448 1.4e-27 108.0 COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,25B35@186801|Clostridia,42KCV@68298|Syntrophomonadaceae 186801|Clostridia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_190977_2 1123288.SOV_5c00240 2.2e-126 369.0 COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,4H3HD@909932|Negativicutes 909932|Negativicutes V ABC transporter related protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_190977_3 484770.UFO1_0390 1.1e-117 349.0 COG0845@1|root,COG0845@2|Bacteria,1V0ZP@1239|Firmicutes,4H3ID@909932|Negativicutes 909932|Negativicutes M Auxiliary transport protein, membrane fusion protein (MFP) family protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_190977_4 497964.CfE428DRAFT_4070 1.18e-30 115.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_190977_7 545276.KB898724_gene1930 2.63e-32 114.0 COG3450@1|root,COG3450@2|Bacteria,1N4VS@1224|Proteobacteria,1SC4C@1236|Gammaproteobacteria,1WYPY@135613|Chromatiales 135613|Chromatiales S Ethanolamine utilisation protein EutQ - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_190977_9 572544.Ilyop_1183 1.27e-136 392.0 COG2022@1|root,COG2022@2|Bacteria,37958@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_190977_10 556263.FSEG_00187 1.24e-163 469.0 COG0502@1|root,COG0502@2|Bacteria,3798H@32066|Fusobacteria 32066|Fusobacteria C Biotin and Thiamin Synthesis associated domain thiH - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM k59_190977_11 1319815.HMPREF0202_00185 3.55e-47 159.0 COG0476@1|root,COG0476@2|Bacteria,379ZW@32066|Fusobacteria 32066|Fusobacteria H ThiF family thiF - 2.7.7.73 ko:K03148 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_909586_2 402612.FP0245 5.59e-142 407.0 COG3645@1|root,COG3645@2|Bacteria,4NJ37@976|Bacteroidetes,1I7TD@117743|Flavobacteriia,2NU5X@237|Flavobacterium 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 dinD - - ko:K14623 - - - - ko00000,ko03400 - - - Bro-N k59_909586_4 1123326.JFBL01000001_gene1277 3.35e-63 199.0 COG2077@1|root,COG2077@2|Bacteria,1Q5Y2@1224|Proteobacteria,4321Y@68525|delta/epsilon subdivisions,2YS92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides - - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - - k59_452514_1 886882.PPSC2_c3391 1.52e-48 179.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_551604_1 720554.Clocl_1116 1.49e-12 71.2 COG0850@1|root,COG0850@2|Bacteria,1VAPC@1239|Firmicutes,24MV1@186801|Clostridia,3WM6I@541000|Ruminococcaceae 186801|Clostridia D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization minC - - ko:K03610 - - - - ko00000,ko03036,ko04812 - - - MinC_C k59_551604_2 572544.Ilyop_1719 1.26e-72 236.0 COG0595@1|root,COG0595@2|Bacteria,378XM@32066|Fusobacteria 32066|Fusobacteria J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_876681_1 933262.AXAM01000025_gene3400 5.98e-64 204.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,2MJUG@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_224364_1 1391646.AVSU01000126_gene2189 2.52e-34 124.0 COG0454@1|root,COG0456@2|Bacteria,1V99J@1239|Firmicutes,24GKN@186801|Clostridia 186801|Clostridia K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_452521_2 1123367.C666_14160 9.34e-90 288.0 COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2WGGY@28216|Betaproteobacteria,2KVF7@206389|Rhodocyclales 206389|Rhodocyclales V ABC-type multidrug transport system, ATPase component - - - ko:K13926 - - - - ko00000 - - - ABC2_membrane_3,ABC_tran k59_616442_1 1304885.AUEY01000006_gene770 7.66e-34 120.0 COG2204@1|root,COG2204@2|Bacteria,1N33V@1224|Proteobacteria,42U3U@68525|delta/epsilon subdivisions,2WQ8H@28221|Deltaproteobacteria,2MKHM@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_616442_2 1121396.KB892990_gene4475 1e-22 96.3 2AHDX@1|root,332YP@2|Bacteria,1NCQ1@1224|Proteobacteria,42VS4@68525|delta/epsilon subdivisions,2WS76@28221|Deltaproteobacteria,2MNYR@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_22622_1 509191.AEDB02000109_gene4982 1.02e-08 54.7 COG0135@1|root,COG0135@2|Bacteria,1V6Y0@1239|Firmicutes,24HBQ@186801|Clostridia,3WJH1@541000|Ruminococcaceae 186801|Clostridia E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_588511_1 246197.MXAN_3600 3.07e-44 157.0 COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,42UR2@68525|delta/epsilon subdivisions,2WQER@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_163536_1 1173028.ANKO01000021_gene3774 5.32e-10 62.4 COG2755@1|root,COG2755@2|Bacteria,1G19N@1117|Cyanobacteria,1H7AM@1150|Oscillatoriales 1117|Cyanobacteria E GDSL-like lipase acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 k59_163536_2 1492737.FEM08_12810 2.15e-79 250.0 COG5434@1|root,COG5434@2|Bacteria,4NEM8@976|Bacteroidetes,1HYB5@117743|Flavobacteriia,2NUI1@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_882726_1 1122931.AUAE01000005_gene3314 4.62e-25 100.0 COG0454@1|root,COG0454@2|Bacteria,4NU6Y@976|Bacteroidetes,2G161@200643|Bacteroidia 976|Bacteroidetes K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 k59_392372_1 278957.ABEA03000126_gene3697 2.38e-08 61.2 COG3210@1|root,COG3210@2|Bacteria,46XZF@74201|Verrucomicrobia,3K8NZ@414999|Opitutae 414999|Opitutae U Passenger-associated-transport-repeat - - - - - - - - - - - - PATR k59_653903_1 649639.Bcell_3103 3.08e-54 187.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,1ZD5J@1386|Bacillus 91061|Bacilli NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02243,ko:K02652 - M00429 - - ko00000,ko00002,ko02035,ko02044 3.A.14.1,3.A.15.2 - - T2SSE,T2SSE_N k59_523128_1 1168034.FH5T_13275 6.58e-101 309.0 COG3250@1|root,COG3250@2|Bacteria,4NFPC@976|Bacteroidetes,2FPUZ@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_457746_1 469615.FGAG_01202 1.54e-124 373.0 COG0769@1|root,COG0769@2|Bacteria,37925@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_621415_1 2340.JV46_18900 2.14e-34 121.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam Rhodanese-like - - - - - - - - - - - - Rhodanese k59_65646_1 1123326.JFBL01000015_gene2463 1.17e-21 96.3 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2YMN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA_synt_2f k59_523326_1 28229.ND2E_3952 2.76e-49 164.0 COG1651@1|root,COG1651@2|Bacteria,1MVS2@1224|Proteobacteria,1S9FH@1236|Gammaproteobacteria,2Q6PD@267889|Colwelliaceae 1236|Gammaproteobacteria O Thioredoxin - - - - - - - - - - - - Thioredoxin_4 k59_33017_1 572544.Ilyop_0913 2.92e-102 307.0 COG0004@1|root,COG0004@2|Bacteria,37ANZ@32066|Fusobacteria 32066|Fusobacteria P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_33017_2 551789.ATVJ01000001_gene1485 1.12e-37 130.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,43XY4@69657|Hyphomonadaceae 28211|Alphaproteobacteria K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II k59_33017_3 1118235.CAJH01000013_gene765 3.12e-50 169.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,1X4JP@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA k59_33017_4 572544.Ilyop_1078 2.28e-156 454.0 COG0369@1|root,COG1151@2|Bacteria 2|Bacteria C hydroxylamine reductase activity hcp GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - iAF987.Gmet_2834 Prismane k59_752190_2 394221.Mmar10_0350 1.24e-41 152.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,43ZFF@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster MA20_01050 - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_882937_1 572544.Ilyop_0006 4.51e-221 627.0 COG0187@1|root,COG0187@2|Bacteria,3789U@32066|Fusobacteria 32066|Fusobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_882937_2 572544.Ilyop_0007 6.66e-311 868.0 COG0188@1|root,COG0188@2|Bacteria,3787P@32066|Fusobacteria 32066|Fusobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_327261_1 15368.BRADI3G27332.1 1.37e-90 273.0 2CMAK@1|root,2QPT8@2759|Eukaryota,37MKA@33090|Viridiplantae,3GD5I@35493|Streptophyta,3KY9T@4447|Liliopsida,3IAPE@38820|Poales 35493|Streptophyta C Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions petA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - ko:K02634 ko00195,ko01100,map00195,map01100 M00162 - - ko00000,ko00001,ko00002,ko00194 - - - Apocytochr_F_C,Apocytochr_F_N k59_261840_1 1168034.FH5T_05045 1.03e-52 178.0 COG1044@1|root,COG1044@2|Bacteria,4NE5G@976|Bacteroidetes,2FMZE@200643|Bacteroidia 976|Bacteroidetes M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_131041_1 228405.HNE_2105 2.28e-09 58.5 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2U7CZ@28211|Alphaproteobacteria,43XE9@69657|Hyphomonadaceae 28211|Alphaproteobacteria M COG2853 Surface lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_131041_2 1123073.KB899241_gene2048 4.02e-37 135.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1X73J@135614|Xanthomonadales 135614|Xanthomonadales Q ABC-type transport system involved in resistance to organic solvents auxiliary component - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_229174_1 768671.ThimaDRAFT_4701 7.41e-86 272.0 COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_882947_1 1348635.BBJY01000011_gene1188 5.58e-109 331.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1XSPF@135623|Vibrionales 135623|Vibrionales KL ATP-dependent helicase yoaA - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_523338_1 1215092.PA6_010_00560 5.4e-25 99.0 COG0625@1|root,COG0625@2|Bacteria,1MXHH@1224|Proteobacteria,1RNWZ@1236|Gammaproteobacteria,1YCS0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Belongs to the GST superfamily gstA - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_3,GST_N,GST_N_3 k59_523338_2 1150398.JIBJ01000004_gene2969 4.91e-16 79.3 COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,1W7WG@1268|Micrococcaceae 201174|Actinobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 k59_948280_1 522306.CAP2UW1_1254 8.49e-36 126.0 COG3133@1|root,COG3133@2|Bacteria 2|Bacteria M Outer membrane lipoprotein pcp - - ko:K06077 - - - - ko00000 - - - Rick_17kDa_Anti k59_294534_1 413404.Rmag_0035 1.1e-16 79.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1J4DV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - iJN746.PP_0104 COX1 k59_294534_2 1122599.AUGR01000001_gene168 2.29e-85 263.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XIU7@135619|Oceanospirillales 135619|Oceanospirillales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_196457_2 1280679.ATVX01000019_gene3339 5.12e-24 95.5 COG2076@1|root,COG2076@2|Bacteria,1VFDI@1239|Firmicutes,24S4I@186801|Clostridia 186801|Clostridia P Multidrug Resistance protein - - - - - - - - - - - - EamA,Multi_Drug_Res,TPT k59_163797_1 396588.Tgr7_0764 2.01e-80 261.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1WX75@135613|Chromatiales 135613|Chromatiales M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_392627_1 572544.Ilyop_1518 1.71e-31 119.0 28NK8@1|root,2ZBM2@2|Bacteria,379ZF@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_392627_2 1408439.JHXW01000012_gene843 1.08e-53 174.0 COG2190@1|root,COG2190@2|Bacteria,37A1G@32066|Fusobacteria 32066|Fusobacteria G PTS system crr - - ko:K02777 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1 - - PTS_EIIA_1 k59_686816_1 1168034.FH5T_09325 4.46e-39 135.0 COG1309@1|root,COG1309@2|Bacteria,4NNNT@976|Bacteroidetes,2FS2Z@200643|Bacteroidia 976|Bacteroidetes K transcriptional regulator, TetR family qacR - - - - - - - - - - - TetR_C_5,TetR_N k59_882956_1 1123392.AQWL01000002_gene1812 2.27e-155 458.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,1KS58@119069|Hydrogenophilales 119069|Hydrogenophilales S Sodium:solute symporter family - - - - - - - - - - - - SSF k59_784834_1 640081.Dsui_2108 8.15e-79 262.0 COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,2VXDT@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase - - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,Helicase_C,Peptidase_C14 k59_458006_2 1168034.FH5T_11190 1.08e-55 179.0 COG2013@1|root,COG2013@2|Bacteria,4NFNA@976|Bacteroidetes,2FWBE@200643|Bacteroidia 976|Bacteroidetes S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k59_621453_1 1236514.BAKL01000033_gene2840 5.5e-76 239.0 COG4935@1|root,COG4935@2|Bacteria,4NH8G@976|Bacteroidetes,2G16U@200643|Bacteroidia,4AVH5@815|Bacteroidaceae 976|Bacteroidetes O CotH kinase protein cotH - - - - - - - - - - - CotH k59_556080_1 1265313.HRUBRA_00853 1.91e-44 163.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2BS@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_131058_1 265072.Mfla_2297 6.03e-14 73.6 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,2KKRZ@206350|Nitrosomonadales 206350|Nitrosomonadales H PFAM MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_294546_1 1165841.SULAR_07795 4.64e-104 318.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42MYT@68525|delta/epsilon subdivisions,2YMKP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_621457_2 1156919.QWC_24005 8.75e-38 134.0 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VJ6G@28216|Betaproteobacteria,3T3D2@506|Alcaligenaceae 28216|Betaproteobacteria S Carboxylesterase estB - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_359946_1 269799.Gmet_2039 9.95e-69 219.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1PEX0@1224|Proteobacteria,437E6@68525|delta/epsilon subdivisions,2XA28@28221|Deltaproteobacteria,43VWH@69541|Desulfuromonadales 28221|Deltaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_850305_1 1168034.FH5T_21195 9.57e-177 515.0 COG1629@1|root,COG1629@2|Bacteria,4NFFN@976|Bacteroidetes,2G3GJ@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug k59_163818_1 443143.GM18_2244 9.67e-13 69.7 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_163818_2 1453498.LG45_03810 9.67e-09 63.5 2ECA2@1|root,3368E@2|Bacteria,4PCFT@976|Bacteroidetes,1IMU1@117743|Flavobacteriia,2NUS9@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - Wzy_C k59_915618_1 713587.THITH_12885 3.13e-111 342.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_274_1 696281.Desru_0827 3.8e-94 307.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae 186801|Clostridia E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_392645_1 1266925.JHVX01000010_gene1321 1.19e-32 127.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,372B6@32003|Nitrosomonadales 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily dppF - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_621468_1 388051.AUFE01000016_gene5841 2.19e-75 237.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria 1224|Proteobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_686844_1 1304885.AUEY01000002_gene347 2.24e-138 405.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MI66@213118|Desulfobacterales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_654153_1 572544.Ilyop_0683 7.65e-18 88.6 COG3063@1|root,COG3063@2|Bacteria,37AGC@32066|Fusobacteria 32066|Fusobacteria NU Tetratricopeptide repeat - - - - - - - - - - - - TPR_19,TPR_2 k59_654153_2 572544.Ilyop_0682 2.94e-67 213.0 COG2928@1|root,COG2928@2|Bacteria,3796C@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_654153_3 572544.Ilyop_0681 5.13e-172 495.0 COG1253@1|root,COG1253@2|Bacteria,378TX@32066|Fusobacteria 32066|Fusobacteria P CBS domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_654153_4 398527.Bphyt_6307 2.27e-05 50.4 COG0517@1|root,COG0517@2|Bacteria,1RE9W@1224|Proteobacteria,2VRIH@28216|Betaproteobacteria,1K4C0@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - BON,CBS k59_654153_5 351160.LRC143 1.7e-58 186.0 COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2N9MF@224756|Methanomicrobia 224756|Methanomicrobia F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - iAF692.Mbar_A3385 NDK k59_654153_6 388467.A19Y_1388 4.25e-25 102.0 COG0511@1|root,COG0511@2|Bacteria,1G6MY@1117|Cyanobacteria,1HBRH@1150|Oscillatoriales 1117|Cyanobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_654153_7 572544.Ilyop_0677 1.29e-68 211.0 COG4492@1|root,COG4492@2|Bacteria,37AFD@32066|Fusobacteria 32066|Fusobacteria S Belongs to the UPF0735 family - - 5.4.99.5 ko:K06209 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4 k59_654153_8 622312.ROSEINA2194_03802 1.35e-112 333.0 COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia 186801|Clostridia F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_654153_9 572544.Ilyop_0675 3.6e-97 288.0 COG2344@1|root,COG2344@2|Bacteria,37A9B@32066|Fusobacteria 32066|Fusobacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N k59_654153_10 572544.Ilyop_0674 2e-158 451.0 COG0223@1|root,COG0223@2|Bacteria,378MT@32066|Fusobacteria 32066|Fusobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_654153_11 1319815.HMPREF0202_01883 4.51e-66 206.0 COG0242@1|root,COG0242@2|Bacteria,379JX@32066|Fusobacteria 32066|Fusobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_196492_2 1125863.JAFN01000001_gene434 2.65e-07 55.8 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_359971_1 314278.NB231_17318 1.76e-08 54.3 COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,1RRV0@1236|Gammaproteobacteria,1WZGX@135613|Chromatiales 135613|Chromatiales L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_359971_2 1049564.TevJSym_ai00810 3.87e-128 372.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1J54U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008412,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - iZ_1308.Z5639 UbiA k59_490683_1 572477.Alvin_1853 1.67e-35 133.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1WX31@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_490683_2 2340.JV46_21960 4.49e-05 45.1 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_490685_1 1165841.SULAR_09639 1.21e-72 239.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,43BJ8@68525|delta/epsilon subdivisions,2YMMJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M penicillin-binding protein pbpA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_686855_1 1168034.FH5T_18795 5.22e-07 50.1 COG0708@1|root,COG0708@2|Bacteria,4NEY3@976|Bacteroidetes,2FNRH@200643|Bacteroidia 976|Bacteroidetes L exodeoxyribonuclease III xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_686855_2 1347342.BN863_9830 5.89e-17 81.3 28HY3@1|root,2Z83I@2|Bacteria,4NHFN@976|Bacteroidetes,1HZ8A@117743|Flavobacteriia 976|Bacteroidetes S phosphoenolpyruvate carboxykinase (diphosphate) activity - - - - - - - - - - - - - k59_882993_1 666681.M301_0394 1.29e-60 198.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,2KM94@206350|Nitrosomonadales 206350|Nitrosomonadales S molybdopterin binding domain - - - - - - - - - - - - MoCF_biosynth k59_556107_1 572544.Ilyop_0607 4.11e-18 89.7 COG2911@1|root,COG2911@2|Bacteria,3792H@32066|Fusobacteria 32066|Fusobacteria S Psort location OuterMembrane, score - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_752274_1 1442598.JABW01000003_gene90 2.22e-123 364.0 COG0438@1|root,COG0438@2|Bacteria,1MUYN@1224|Proteobacteria,42S1I@68525|delta/epsilon subdivisions 1224|Proteobacteria M Domain of unknown function (DUF1972) - - - - - - - - - - - - DUF1972,Glyco_trans_1_2,Glycos_transf_1 k59_725119_1 572544.Ilyop_1472 2.85e-86 281.0 COG0587@1|root,COG0587@2|Bacteria,378JD@32066|Fusobacteria 32066|Fusobacteria L DNA polymerase III - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_725119_2 1095747.HMPREF1049_0406 1.08e-211 605.0 COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,379DH@32066|Fusobacteria 32066|Fusobacteria G PTS system, fructose-specific IIB fruA - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB k59_823505_1 1248232.BANQ01000116_gene1808 1.12e-33 121.0 296Z4@1|root,2ZU7P@2|Bacteria,1PAT0@1224|Proteobacteria,1SW3D@1236|Gammaproteobacteria,1XXPY@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - Cupin_2 k59_921975_1 402881.Plav_1729 1.07e-71 230.0 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2U5M0@28211|Alphaproteobacteria,1JQJA@119043|Rhodobiaceae 28211|Alphaproteobacteria EGP major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 k59_235065_1 1532557.JL37_12620 1.07e-27 108.0 COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2VIX4@28216|Betaproteobacteria,3T5CY@506|Alcaligenaceae 28216|Betaproteobacteria S Urea ABC transporter ATP-binding protein urtD - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C k59_235065_2 765913.ThidrDRAFT_2217 3.46e-86 263.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,1RMAZ@1236|Gammaproteobacteria,1WX99@135613|Chromatiales 135613|Chromatiales U Belongs to the binding-protein-dependent transport system permease family - - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_888088_1 1386089.N865_20465 4.86e-07 53.1 COG2267@1|root,COG2267@2|Bacteria,2I3E4@201174|Actinobacteria 201174|Actinobacteria I Belongs to the peptidase S33 family - - 3.5.1.101 ko:K18457 - - - - ko00000,ko01000 - - - Abhydrolase_1 k59_888088_2 455436.DS989810_gene457 5.26e-05 50.4 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,464UF@72275|Alteromonadaceae 1236|Gammaproteobacteria E chorismate mutase pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_2667 CM_2,DAHP_synth_1,PDT k59_299895_1 318464.IO99_08055 2.2e-38 139.0 COG2846@1|root,COG2846@2|Bacteria,1UYJV@1239|Firmicutes,24GZI@186801|Clostridia,36FII@31979|Clostridiaceae 186801|Clostridia D Di-iron-containing protein involved in the repair of iron-sulfur clusters ric - - ko:K07322 - - - - ko00000 - - - Hemerythrin,ScdA_N k59_1019581_1 1444310.JANV01000124_gene3018 1.02e-16 75.5 COG0477@1|root,COG2814@2|Bacteria,1VGN4@1239|Firmicutes,4HNVP@91061|Bacilli,1ZIWN@1386|Bacillus 91061|Bacilli EGP Domain of unknown function (DUF3817) ydzA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - DUF3817 k59_1019581_2 1249480.B649_11325 9.44e-17 80.9 2C76X@1|root,2ZM1W@2|Bacteria,1P5JD@1224|Proteobacteria,42P9T@68525|delta/epsilon subdivisions,2YMRC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_202157_1 1319815.HMPREF0202_02543 1.54e-177 505.0 COG1960@1|root,COG1960@2|Bacteria,378TZ@32066|Fusobacteria 32066|Fusobacteria C Acyl-CoA dehydrogenase, N-terminal domain bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_202157_2 572544.Ilyop_0279 2.51e-140 401.0 COG2086@1|root,COG2086@2|Bacteria,378IK@32066|Fusobacteria 32066|Fusobacteria C Electron transfer flavoprotein domain etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_202157_3 469618.FVAG_01711 1.55e-155 446.0 COG2025@1|root,COG2025@2|Bacteria,378IG@32066|Fusobacteria 32066|Fusobacteria C Electron transfer flavoprotein FAD-binding domain etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_202157_4 572544.Ilyop_1540 1.29e-77 236.0 COG0290@1|root,COG0290@2|Bacteria,37A7D@32066|Fusobacteria 32066|Fusobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_202157_5 572544.Ilyop_1539 2.27e-26 98.2 COG0291@1|root,COG0291@2|Bacteria,37ANM@32066|Fusobacteria 32066|Fusobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_202157_6 556263.FSEG_00093 7.68e-54 171.0 COG0292@1|root,COG0292@2|Bacteria,37A4W@32066|Fusobacteria 32066|Fusobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_202157_7 572544.Ilyop_1537 8.33e-69 214.0 COG0457@1|root,COG0457@2|Bacteria,37ABQ@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 k59_202157_8 748727.CLJU_c02780 4.64e-08 58.2 COG0484@1|root,COG0484@2|Bacteria,1V1GK@1239|Firmicutes,2494E@186801|Clostridia,36GYW@31979|Clostridiaceae 186801|Clostridia O molecular chaperone DnaJ - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,TPR_2 k59_986787_1 156889.Mmc1_0375 9.72e-183 538.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,2TUXR@28211|Alphaproteobacteria 28211|Alphaproteobacteria N ABC transporter permease - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_529831_1 749222.Nitsa_0411 2.18e-29 112.0 2AIWS@1|root,319ED@2|Bacteria,1Q2HE@1224|Proteobacteria,42VQ7@68525|delta/epsilon subdivisions,2YQ77@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_627396_1 385682.AFSL01000089_gene927 4.37e-97 313.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FW53@200643|Bacteroidia,3XJUV@558415|Marinilabiliaceae 976|Bacteroidetes H TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_594239_1 2340.JV46_23920 5.55e-89 267.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1J4MF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_594239_2 631362.Thi970DRAFT_03995 3.65e-16 77.0 COG4619@1|root,COG4619@2|Bacteria,1QTWV@1224|Proteobacteria,1S627@1236|Gammaproteobacteria,1WXSI@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran k59_299904_2 1049564.TevJSym_bb00300 4.46e-104 307.0 COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1S0ZZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT Response regulator receiver - - - - - - - - - - - - PAS,PAS_9,Response_reg k59_856210_1 593907.Celgi_1065 6.91e-17 82.8 COG0642@1|root,COG2205@2|Bacteria,2I3HN@201174|Actinobacteria,4F0KP@85016|Cellulomonadaceae 201174|Actinobacteria T SMART ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA k59_856210_2 936548.HMPREF1136_0753 1.03e-38 134.0 COG0745@1|root,COG0745@2|Bacteria,2GP1I@201174|Actinobacteria,4D3AC@85005|Actinomycetales 201174|Actinobacteria K Response regulator receiver domain protein vicR - - - - - - - - - - - Response_reg,Trans_reg_C k59_496826_1 631362.Thi970DRAFT_00738 4.03e-83 249.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1WX8K@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_823523_1 637910.ROD_p2491 1.9e-16 75.1 2DPI7@1|root,3326R@2|Bacteria,1N896@1224|Proteobacteria 1224|Proteobacteria S TrbC/VIRB2 family - - - ko:K03197 ko03070,ko05134,map03070,map05134 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - TrbC k59_823523_2 556267.HWAG_01602 2.46e-11 65.5 COG3451@1|root,COG3702@1|root,COG3451@2|Bacteria,COG3702@2|Bacteria,1MXH0@1224|Proteobacteria,42N1G@68525|delta/epsilon subdivisions,2YME2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U COG3451 Type IV secretory pathway, VirB4 components cagE - - ko:K03199,ko:K12108 ko03070,ko05120,map03070,map05120 M00333,M00564 - - ko00000,ko00001,ko00002,ko02044 3.A.7,3.A.7.12.1 - - AAA_10,CagE_TrbE_VirB,VirB3 k59_888114_1 1249480.B649_06825 1.04e-98 295.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42QA8@68525|delta/epsilon subdivisions,2YNH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,AAA_3 k59_398396_2 572477.Alvin_1498 1.97e-34 122.0 2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,1S999@1236|Gammaproteobacteria,1WYNZ@135613|Chromatiales 135613|Chromatiales J May protect the nitrogenase Fe-Mo protein from oxidative damage nifW - - ko:K02595 - - - - ko00000 - - - NifW k59_299908_1 519989.ECTPHS_00525 1.45e-98 294.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1WWX4@135613|Chromatiales 135613|Chromatiales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_790305_1 933262.AXAM01000018_gene1017 1.46e-77 250.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria,2MIC5@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8,Fer4_9 k59_267174_1 1168034.FH5T_09785 8.07e-62 197.0 COG1999@1|root,COG1999@2|Bacteria,4NU1J@976|Bacteroidetes,2FXFP@200643|Bacteroidia 976|Bacteroidetes S signal sequence binding - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_627419_1 216595.PFLU_2584 8.14e-63 209.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,1YN9X@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria G Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system - - 3.6.3.17 ko:K10441,ko:K10545,ko:K17215 ko02010,map02010 M00212,M00215,M00593 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4 - - ABC_tran k59_366072_1 857087.Metme_1916 5.74e-43 158.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XER8@135618|Methylococcales 135618|Methylococcales JKL DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_594268_1 1565314.OA34_07795 1.87e-11 64.3 COG3920@1|root,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,42PDP@68525|delta/epsilon subdivisions,2YMI8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T two-component sensor histidine kinase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA_2 k59_627428_1 398580.Dshi_2295 1.63e-25 104.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_627428_2 1116375.VEJY3_04050 1.94e-44 156.0 COG1680@1|root,COG1680@2|Bacteria,1MY01@1224|Proteobacteria,1RNUI@1236|Gammaproteobacteria,1XZIB@135623|Vibrionales 135623|Vibrionales V Beta-lactamase - - 3.5.2.6 ko:K01467 ko01501,ko02020,map01501,map02020 M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000 - - - Beta-lactamase k59_235125_2 697281.Mahau_0035 1.45e-63 199.0 COG0454@1|root,COG0456@2|Bacteria,1VCET@1239|Firmicutes,24MTN@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_333715_1 497321.C664_18007 4.14e-72 230.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,2KUUJ@206389|Rhodocyclales 206389|Rhodocyclales H Aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_953949_1 1168034.FH5T_05850 7.23e-183 537.0 COG0306@1|root,COG0306@2|Bacteria,4NFCB@976|Bacteroidetes,2FN8Q@200643|Bacteroidia 976|Bacteroidetes U Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - PHO4 k59_170379_1 387093.SUN_1658 1.41e-25 104.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2YM8M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_170379_2 762966.HMPREF9439_00205 3.83e-30 122.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,4PQ8D@995019|Sutterellaceae 28216|Betaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_562396_1 393595.ABO_0785 3.37e-70 237.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XH4B@135619|Oceanospirillales 135619|Oceanospirillales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_170380_1 1049564.TevJSym_ak01000 1.98e-41 147.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_170380_2 396588.Tgr7_2763 6.6e-24 100.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales 135613|Chromatiales CH Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 - - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_235129_1 1168034.FH5T_12385 3.83e-30 118.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,4NEDE@976|Bacteroidetes,2FKZJ@200643|Bacteroidia 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_954315_22 292563.Cyast_1984 4.25e-34 133.0 2F022@1|root,33T5U@2|Bacteria,1GD80@1117|Cyanobacteria 1117|Cyanobacteria S Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_2 k59_954315_23 1254432.SCE1572_39055 4.74e-07 56.2 COG0500@1|root,COG0500@2|Bacteria,1QV5S@1224|Proteobacteria,43DEN@68525|delta/epsilon subdivisions 1224|Proteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_235630_1 926569.ANT_18150 4.3e-14 72.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2G69H@200795|Chloroflexi 200795|Chloroflexi C Pyruvate flavodoxin ferredoxin oxidoreductase domain protein - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_235630_2 383372.Rcas_2309 2.49e-40 143.0 COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi,374ZH@32061|Chloroflexia 32061|Chloroflexia C PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_824033_1 485913.Krac_8838 1.61e-40 145.0 COG3875@1|root,COG3875@2|Bacteria,2G8B3@200795|Chloroflexi 200795|Chloroflexi S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 k59_824033_2 130081.XP_005707591.1 3.37e-25 103.0 COG0362@1|root,KOG2653@2759|Eukaryota 2759|Eukaryota G D-gluconate metabolic process PGD GO:0000166,GO:0003674,GO:0003824,GO:0004616,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006098,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006952,GO:0006979,GO:0008150,GO:0008152,GO:0009051,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009605,GO:0009607,GO:0009617,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019222,GO:0019321,GO:0019322,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019520,GO:0019521,GO:0019637,GO:0019682,GO:0019693,GO:0019752,GO:0030246,GO:0031406,GO:0032787,GO:0033500,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042221,GO:0042592,GO:0042593,GO:0042742,GO:0042866,GO:0043167,GO:0043168,GO:0043177,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046176,GO:0046177,GO:0046364,GO:0046390,GO:0046394,GO:0046395,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0048519,GO:0048878,GO:0050661,GO:0050662,GO:0050789,GO:0050829,GO:0050896,GO:0051156,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0051716,GO:0055086,GO:0055114,GO:0060255,GO:0061688,GO:0065007,GO:0065008,GO:0070887,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0098542,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.1.1.343,1.1.1.44 ko:K00033,ko:K11511 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko03460,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map03460 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000,ko03036,ko03400 - - iMM904.YHR183W,iND750.YHR183W 6PGD,NAD_binding_2 k59_105441_1 754477.Q7C_2060 5.58e-61 200.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria 1236|Gammaproteobacteria M synthase cfa GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0008825,GO:0009987,GO:0016740,GO:0016741,GO:0030258,GO:0032259,GO:0044237,GO:0044238,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - iEC55989_1330.EC55989_1829,iECIAI1_1343.ECIAI1_1713,iECO103_1326.ECO103_1803,iECSE_1348.ECSE_1785,iEcE24377_1341.EcE24377A_1875 CMAS k59_987458_1 1537917.JU82_07740 1.52e-130 380.0 COG2404@1|root,COG2404@2|Bacteria,1NHB1@1224|Proteobacteria,42NB0@68525|delta/epsilon subdivisions,2YMQ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S phosphohydrolase (DHH superfamily) - - - ko:K07097 - - - - ko00000 - - - DHHA1 k59_431037_1 748247.AZKH_0548 1.31e-87 268.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,2KV7G@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_888732_2 572544.Ilyop_1349 1.28e-167 491.0 COG1480@1|root,COG1480@2|Bacteria,378ZH@32066|Fusobacteria 32066|Fusobacteria S 7TM receptor with intracellular HD hydrolase - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_334327_1 1223410.KN050846_gene2836 5.53e-82 273.0 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,SnoaL_3 k59_398970_1 1168034.FH5T_16670 2.92e-88 267.0 COG0781@1|root,COG0781@2|Bacteria,4NDVR@976|Bacteroidetes,2FMU4@200643|Bacteroidia 976|Bacteroidetes K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_398970_2 1168034.FH5T_16665 1.06e-14 71.6 2CG1Y@1|root,330K1@2|Bacteria,4NYMT@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 k59_105449_2 756272.Plabr_3405 2.57e-27 111.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_16,GerE,Response_reg k59_594968_1 1042377.AFPJ01000023_gene657 5.06e-53 190.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria 1224|Proteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - SdrD_B k59_661117_1 1168034.FH5T_13660 4.7e-99 306.0 COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,2FMK5@200643|Bacteroidia 976|Bacteroidetes T Tetratricopeptide repeat protein batD - - - - - - - - - - - BatD,TPR_2 k59_725674_2 469616.FMAG_01662 1.36e-39 132.0 2CG49@1|root,32Y3Y@2|Bacteria,37AQ4@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_725674_3 469616.FMAG_00138 2.29e-155 446.0 COG1136@1|root,COG1136@2|Bacteria,379EK@32066|Fusobacteria 32066|Fusobacteria V ABC transporter, ATP-binding protein - - - - - - - - - - - - ABC_tran k59_72377_1 990073.ATHU01000001_gene1687 4.95e-75 236.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,42NEN@68525|delta/epsilon subdivisions,2YN4D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_138194_1 314285.KT71_08279 9.88e-52 168.0 COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria,1S6QM@1236|Gammaproteobacteria,1J9ZC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O redox protein, regulator of disulfide bond formation - - - - - - - - - - - - OsmC k59_138194_2 742766.HMPREF9455_03035 1.29e-29 116.0 COG3033@1|root,COG3033@2|Bacteria,4NEP4@976|Bacteroidetes,2FMRS@200643|Bacteroidia,22WWU@171551|Porphyromonadaceae 976|Bacteroidetes E Tryptophanase tpl - - - - - - - - - - - Beta_elim_lyase k59_728798_50 768671.ThimaDRAFT_3356 8.11e-115 339.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_728798_51 228410.NE2298 8.77e-53 179.0 COG2267@1|root,COG2267@2|Bacteria,1N2R9@1224|Proteobacteria,2VRME@28216|Betaproteobacteria,372D9@32003|Nitrosomonadales 28216|Betaproteobacteria I The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters bioH - 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_728798_52 572477.Alvin_0525 1.44e-178 508.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_728798_53 1249627.D779_1614 1.73e-170 484.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1WWXZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_728798_54 1229205.BUPH_04162 2.16e-35 133.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria,1K0KN@119060|Burkholderiaceae 28216|Betaproteobacteria S Competence protein comF - - - - - - - - - - - Pribosyltran k59_728798_55 1049564.TevJSym_av00010 4.35e-142 422.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1J5GB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_174653_1 1417296.U879_08095 4.2e-115 337.0 COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,2U4AQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_958122_1 1033802.SSPSH_003549 2.62e-91 281.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Glutamate synthase gltD GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3503,iYL1228.KPN_03625 Fer4_11,Fer4_20,Pyr_redox_2 k59_239358_1 367737.Abu_2014 9.63e-136 396.0 COG1363@1|root,COG1363@2|Bacteria,1MWQV@1224|Proteobacteria,42Y9B@68525|delta/epsilon subdivisions,2YR4Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 k59_239358_2 517417.Cpar_0326 4.57e-181 533.0 COG1067@1|root,COG1067@2|Bacteria,1FETE@1090|Chlorobi 1090|Chlorobi O PFAM peptidase S16 lon domain protein - - - - - - - - - - - - AAA_32,Lon_C k59_632019_1 933262.AXAM01000030_gene797 2.4e-66 210.0 COG0289@1|root,COG0289@2|Bacteria,1QB39@1224|Proteobacteria,42NRC@68525|delta/epsilon subdivisions,2WJGM@28221|Deltaproteobacteria,2MJ2I@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the DapB family - - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_696921_1 572480.Arnit_3036 1.6e-109 322.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,42N20@68525|delta/epsilon subdivisions,2YN0N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 k59_696921_2 555779.Dthio_PD3276 2.38e-48 182.0 COG0438@1|root,COG0613@1|root,COG0438@2|Bacteria,COG0613@2|Bacteria,1MUB7@1224|Proteobacteria,42N14@68525|delta/epsilon subdivisions,2WIKT@28221|Deltaproteobacteria,2M8E0@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_468380_1 1298867.AUES01000051_gene4507 2.01e-55 191.0 COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2U22Z@28211|Alphaproteobacteria,3K3DU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,GAF,HlyD_3,HlyD_D23 k59_142465_1 941449.dsx2_0266 1.41e-61 203.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria,2M9FH@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_303823_1 933262.AXAM01000002_gene564 4e-05 45.4 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42NQT@68525|delta/epsilon subdivisions,2WJKD@28221|Deltaproteobacteria,2MJB8@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM sodium sulfate symporter - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_303823_2 1265505.ATUG01000002_gene1350 3.97e-41 139.0 COG2204@1|root,COG2204@2|Bacteria,1RJP7@1224|Proteobacteria,42SDG@68525|delta/epsilon subdivisions,2WP9A@28221|Deltaproteobacteria,2MK9J@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_434705_1 886293.Sinac_5044 4.2e-19 92.8 COG1505@1|root,COG1505@2|Bacteria,2IXRJ@203682|Planctomycetes 203682|Planctomycetes E Prolyl oligopeptidase - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_207133_1 570952.ATVH01000003_gene696 8.97e-86 271.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria,2JQA5@204441|Rhodospirillales 204441|Rhodospirillales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1023471_1 387093.SUN_1796 2.06e-101 319.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2YMIZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_76353_1 1168034.FH5T_14405 2.76e-54 175.0 COG1018@1|root,COG1018@2|Bacteria,4PCD8@976|Bacteroidetes,2FXQD@200643|Bacteroidia 976|Bacteroidetes C Oxidoreductase FAD-binding domain - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_76353_2 1168034.FH5T_14400 4.19e-105 312.0 COG4213@1|root,COG4213@2|Bacteria,4NNBW@976|Bacteroidetes,2FWT8@200643|Bacteroidia 976|Bacteroidetes G Periplasmic binding protein domain - - - ko:K10543 ko02010,map02010 M00215 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.4 - - Peripla_BP_4 k59_991642_1 1056820.KB900699_gene1302 1.51e-97 304.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,2PMZF@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L DNA polymerase III tau subunit V interacting with alpha dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5 k59_599361_1 1453505.JASY01000001_gene3615 9.26e-90 286.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia,2NVHB@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_501780_1 84531.JMTZ01000070_gene1813 1.24e-95 288.0 COG0604@1|root,COG0604@2|Bacteria,1MXCV@1224|Proteobacteria,1S13Q@1236|Gammaproteobacteria,1XCAC@135614|Xanthomonadales 135614|Xanthomonadales C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_501780_2 857571.EA1_08939 6.07e-18 83.6 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,3NJ32@468|Moraxellaceae 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_600135_1 944547.ABLL_2114 1.05e-67 226.0 COG4774@1|root,COG4774@2|Bacteria,1QU2Y@1224|Proteobacteria,43CFU@68525|delta/epsilon subdivisions,2YTF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M PFAM TonB-dependent Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - TonB_dep_Rec k59_469039_1 1120792.JAFV01000001_gene685 0.000113 43.9 COG5349@1|root,COG5349@2|Bacteria,1MZDD@1224|Proteobacteria,2UCM4@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG1405 Transcription initiation factor TFIIIB, Brf1 subunit Transcription initiation factor TFIIB - - - - - - - - - - - - DUF983 k59_469039_2 1280952.HJA_11834 8.6e-36 131.0 COG0494@1|root,COG0494@2|Bacteria,1N8EV@1224|Proteobacteria,2TTNV@28211|Alphaproteobacteria,43Y4M@69657|Hyphomonadaceae 28211|Alphaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes MA20_36340 - - - - - - - - - - - NUDIX k59_632789_1 749222.Nitsa_2085 4.63e-89 270.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2YNZT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_632789_2 929558.SMGD1_0332 1.4e-45 152.0 COG0476@1|root,COG0476@2|Bacteria,1P1FY@1224|Proteobacteria,42PK6@68525|delta/epsilon subdivisions,2YNCI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H involved in molybdopterin and thiamine biosynthesis family 2 - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_435431_1 1123054.KB907702_gene1675 1.92e-75 242.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_600140_1 1123229.AUBC01000041_gene3817 2.71e-78 243.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,3JR7B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Methylenetetrahydrofolate reductase metF GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_600140_2 1033730.CAHG01000014_gene1687 4.56e-20 90.1 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4DP5M@85009|Propionibacteriales 201174|Actinobacteria E B12 binding domain metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_632790_1 1304872.JAGC01000009_gene1532 3.06e-94 298.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MAAB@213115|Desulfovibrionales 28221|Deltaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_109835_1 1268072.PSAB_05515 4.92e-46 163.0 COG0477@1|root,COG2814@2|Bacteria,1TRNU@1239|Firmicutes,4HCSX@91061|Bacilli,26RQX@186822|Paenibacillaceae 91061|Bacilli EGP Arabinose efflux permease ybcL - - ko:K08164 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1,Sugar_tr k59_860695_1 118005.AWNK01000003_gene2230 8.98e-103 326.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria 2|Bacteria G chondroitin AC lyase activity ndvB - 2.4.1.12,3.2.1.58 ko:K00694,ko:K01210,ko:K03292 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R00308,R02889,R03115 RC00005,RC00467 ko00000,ko00001,ko01000,ko01003,ko02000 2.A.2,4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,MFS_2 k59_403242_1 1049564.TevJSym_bp00060 1.76e-36 137.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1J4VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08483,ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_403242_2 765912.Thimo_1462 1.14e-81 245.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1WXC4@135613|Chromatiales 135613|Chromatiales L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_632796_1 383372.Rcas_0906 1.23e-112 342.0 COG0747@1|root,COG0747@2|Bacteria,2G7TA@200795|Chloroflexi,377H7@32061|Chloroflexia 32061|Chloroflexia E PFAM extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_371252_1 522373.Smlt0795 5.28e-22 100.0 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1X35F@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec k59_502632_1 563040.Saut_1735 3.31e-13 66.6 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,42QX8@68525|delta/epsilon subdivisions,2YP1G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_502632_2 1537917.JU82_07070 4.88e-143 406.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,42NRX@68525|delta/epsilon subdivisions,2YMSK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_502632_3 709032.Sulku_1895 3.82e-69 210.0 COG2199@1|root,COG3706@2|Bacteria,1N0N3@1224|Proteobacteria,43E7J@68525|delta/epsilon subdivisions,2YTC4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Chemotaxis protein cheY - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_207955_2 390235.PputW619_1665 2.59e-33 130.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1YVV6@136845|Pseudomonas putida group 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_77027_1 1123368.AUIS01000019_gene1219 9.42e-55 195.0 COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales 225057|Acidithiobacillales T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GGDEF,PAS,PAS_4 k59_469057_1 768671.ThimaDRAFT_0913 4.34e-66 214.0 2DBUZ@1|root,2ZB8W@2|Bacteria,1QWGF@1224|Proteobacteria,1SN24@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_403256_1 563040.Saut_0411 4.48e-42 145.0 COG0847@1|root,COG0847@2|Bacteria,1PDD1@1224|Proteobacteria,42MUX@68525|delta/epsilon subdivisions,2YNB6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0847 DNA polymerase III epsilon subunit and related 3'-5' - - 2.7.7.7 ko:K02342,ko:K10857 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_403256_2 931276.Cspa_c44690 9.65e-09 59.3 COG2199@1|root,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,249Y6@186801|Clostridia,36WDP@31979|Clostridiaceae 186801|Clostridia T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,GGDEF,TPR_12,TPR_8 k59_175458_1 572477.Alvin_1546 8.05e-62 209.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_502640_1 1479237.JMLY01000001_gene3626 2.67e-83 251.0 COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,1S54N@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome - - - - - - - - - - - - Ni_hydr_CYTB k59_502640_2 1379281.AVAG01000050_gene937 5.91e-26 106.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,2M9ZJ@213115|Desulfovibrionales 28221|Deltaproteobacteria P Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_C7,Cytochrome_cB k59_304475_3 46234.ANA_C20259 5.42e-07 57.4 COG0739@1|root,COG0739@2|Bacteria,1G42A@1117|Cyanobacteria,1HKFF@1161|Nostocales 1117|Cyanobacteria M Peptidase family M23 - - 3.4.24.75 ko:K08259 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_304475_5 998674.ATTE01000001_gene2051 7.23e-37 127.0 COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,463BZ@72273|Thiotrichales 72273|Thiotrichales S Domain of unknown function (DUF1820) - - - - - - - - - - - - DUF1820 k59_304475_6 396595.TK90_0677 2.94e-69 213.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1WYNT@135613|Chromatiales 135613|Chromatiales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_304475_7 2340.JV46_14620 7.15e-123 357.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1J5RV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB GO:0003674,GO:0003824,GO:0004416,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_304475_8 2340.JV46_14610 1.61e-207 587.0 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_304475_9 765913.ThidrDRAFT_2973 8.38e-28 101.0 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,1SCRA@1236|Gammaproteobacteria,1WYYY@135613|Chromatiales 135613|Chromatiales P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_304475_10 472759.Nhal_0229 6.75e-164 482.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales 135613|Chromatiales S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_304475_12 159087.Daro_2960 4.91e-41 143.0 COG0745@1|root,COG0745@2|Bacteria,1REEH@1224|Proteobacteria,2VRXE@28216|Betaproteobacteria,2KWII@206389|Rhodocyclales 206389|Rhodocyclales T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_304475_13 316056.RPC_4302 1.44e-14 68.2 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2UG8Q@28211|Alphaproteobacteria,3K1X8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_304475_14 583345.Mmol_0398 1.85e-24 98.6 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KMZ0@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM cytochrome c, class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_304475_15 1049564.TevJSym_as00440 6.31e-317 883.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_893769_1 132113.XP_003492791.1 7.1e-128 419.0 COG0085@1|root,COG0222@1|root,KOG0214@2759|Eukaryota,KOG1715@2759|Eukaryota,39VWS@33154|Opisthokonta,3BM6Z@33208|Metazoa,3DDNE@33213|Bilateria 33208|Metazoa K DNA-directed 5'-3' RNA polymerase activity - - - - - - - - - - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_600173_1 476272.RUMHYD_00113 8.06e-27 109.0 COG2182@1|root,COG2182@2|Bacteria,1V3NU@1239|Firmicutes,25F7E@186801|Clostridia,3Y258@572511|Blautia 186801|Clostridia G TupA-like ATPgrasp - - - - - - - - - - - - ATPgrasp_TupA k59_600173_2 211165.AJLN01000134_gene5781 1.89e-16 77.8 COG2940@1|root,COG2940@2|Bacteria,1GKRA@1117|Cyanobacteria,1JMKT@1189|Stigonemataceae 1117|Cyanobacteria S SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - - - - - - - - - - SET k59_992422_1 1122918.KB907249_gene3883 3.35e-103 315.0 COG2079@1|root,COG2079@2|Bacteria,1TSD7@1239|Firmicutes,4HEZJ@91061|Bacilli,26VHQ@186822|Paenibacillaceae 91061|Bacilli S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_1024216_1 1156844.KB891801_gene2894 1.03e-58 188.0 COG1247@1|root,COG1247@2|Bacteria,2IHSY@201174|Actinobacteria 201174|Actinobacteria M acetyltransferase bar - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 k59_567544_1 34506.g2406 2.97e-52 186.0 COG0513@1|root,KOG4197@1|root,KOG0331@2759|Eukaryota,KOG4197@2759|Eukaryota,3AEKB@33154|Opisthokonta,3BXH6@33208|Metazoa,3DEIG@33213|Bilateria 33208|Metazoa A DEAD-box ATP-dependent RNA helicase - - - - - - - - - - - - DEAD,Helicase_C k59_600175_1 1249627.D779_0279 3.51e-19 94.4 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales 135613|Chromatiales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_7215_1 187272.Mlg_2287 6.3e-85 263.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1WX82@135613|Chromatiales 135613|Chromatiales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_42553_1 1249480.B649_05305 2.02e-168 485.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2YMQ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H acetolactate synthase ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_502660_1 1073999.BN137_1709 3.8e-07 51.2 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0022411,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032984,GO:0034641,GO:0034645,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_502660_2 765911.Thivi_0266 6.49e-111 331.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria,1WYH5@135613|Chromatiales 135613|Chromatiales S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_958923_1 580332.Slit_2219 5.41e-62 205.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VH4Z@28216|Betaproteobacteria,44V1P@713636|Nitrosomonadales 28216|Betaproteobacteria E PFAM aminotransferase class I and II alaA - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_77058_1 221288.JH992900_gene345 2.08e-24 96.7 COG3464@1|root,COG3464@2|Bacteria,1GKG0@1117|Cyanobacteria,1JM4P@1189|Stigonemataceae 1117|Cyanobacteria L Transposase - - - - - - - - - - - - - k59_828483_1 944565.HMPREF9127_0835 3.71e-36 138.0 COG1196@1|root,COG1196@2|Bacteria,1U46F@1239|Firmicutes,24C5R@186801|Clostridia,22H4Q@1570339|Peptoniphilaceae 186801|Clostridia D the current gene model (or a revised gene model) may contain a premature stop - - - - - - - - - - - - - k59_860736_1 706587.Desti_2683 4.94e-21 96.3 COG0535@1|root,COG0535@2|Bacteria,1RCZX@1224|Proteobacteria,42RV6@68525|delta/epsilon subdivisions,2X26F@28221|Deltaproteobacteria,2MS7C@213462|Syntrophobacterales 28221|Deltaproteobacteria C Iron-sulfur cluster-binding domain - - - - - - - - - - - - Radical_SAM,SPASM k59_304504_1 42256.RradSPS_0401 1.29e-48 167.0 COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,4CPF1@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_304507_1 1089447.RHAA1_00320 7.68e-34 129.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,1Y7CK@135625|Pasteurellales 135625|Pasteurellales S Protein involved in catalytic activity, hydrolase activity acting on carbon-nitrogen (but not peptide) bonds and carbohydrate metabolic process Z012_04400 - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_535351_1 1408473.JHXO01000006_gene1186 4.17e-16 77.4 28PRQ@1|root,2ZCDG@2|Bacteria,4NMCK@976|Bacteroidetes,2FYMQ@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_535351_2 1168034.FH5T_09600 7.44e-22 94.7 COG0697@1|root,COG0697@2|Bacteria,4NNBQ@976|Bacteroidetes,2FMN9@200643|Bacteroidia 976|Bacteroidetes EG Psort location CytoplasmicMembrane, score 10.00 eamA - - - - - - - - - - - EamA k59_828489_1 1266925.JHVX01000003_gene416 2.94e-08 53.9 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,372MW@32003|Nitrosomonadales 28216|Betaproteobacteria O PFAM Peptidase M48 htpX_2 - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_828489_2 426114.THI_1191 2.11e-39 134.0 COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2VVZF@28216|Betaproteobacteria,1KMTC@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Pterin 4 alpha carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_216114_1 1165841.SULAR_05718 5.64e-11 60.1 COG0712@1|root,COG0712@2|Bacteria,1RFPY@1224|Proteobacteria,42SKR@68525|delta/epsilon subdivisions,2YPHX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_216114_2 1165841.SULAR_05713 7.13e-78 245.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2YMSF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iIT341.HP1134 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_770758_2 631362.Thi970DRAFT_01554 4.08e-53 172.0 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,1WY9G@135613|Chromatiales 135613|Chromatiales MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_770758_3 78398.KS43_07750 1.23e-63 218.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1MS3S@122277|Pectobacterium 1236|Gammaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_0027,iPC815.YPO0475 Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_13866_1 385682.AFSL01000097_gene577 5.22e-87 287.0 COG1595@1|root,COG3291@1|root,COG4733@1|root,COG1595@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,4NHIK@976|Bacteroidetes,2G2Q1@200643|Bacteroidia 976|Bacteroidetes K Glycosyl hydrolase catalytic core - - - - - - - - - - - - CBM_4_9,Glyco_hydro_cc,Laminin_G_3 k59_347339_2 1088721.NSU_3752 2.35e-47 164.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,2K3NJ@204457|Sphingomonadales 204457|Sphingomonadales P COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B,Rhodanese k59_216129_2 335543.Sfum_2416 8.43e-10 59.3 COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,42RZ3@68525|delta/epsilon subdivisions,2WNF0@28221|Deltaproteobacteria,2MRII@213462|Syntrophobacterales 28221|Deltaproteobacteria Q MlaD protein - - - ko:K06192 - - - - ko00000 - - - MlaD k59_216130_1 760154.Sulba_0758 5.04e-17 81.6 COG0589@1|root,COG0589@2|Bacteria,1PAFP@1224|Proteobacteria,42T0F@68525|delta/epsilon subdivisions,2YPFR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Belongs to the universal stress protein A family uspA - - - - - - - - - - - Usp k59_216130_3 563040.Saut_0431 7.52e-14 70.5 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42MF8@68525|delta/epsilon subdivisions,2YN61@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_800061_1 439235.Dalk_5090 4.39e-97 311.0 COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_84272_1 395494.Galf_1309 5.41e-193 576.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE5,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_84272_2 314345.SPV1_04948 4.95e-72 249.0 COG2203@1|root,COG2206@1|root,COG3829@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3829@2|Bacteria,1RAQS@1224|Proteobacteria 1224|Proteobacteria T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - CBS,GAF,GAF_2,HD,HD_5,PAS,PAS_4,PAS_9,Response_reg k59_84272_3 713587.THITH_07575 0.0 1758.0 28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria,1X028@135613|Chromatiales 135613|Chromatiales S phosphoenolpyruvate carboxykinase (diphosphate) activity - - 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 - R00346 RC02741 ko00000,ko00001,ko01000 - - - - k59_84272_4 1304885.AUEY01000002_gene354 5.72e-12 73.2 COG4313@1|root,COG4313@2|Bacteria,1R58D@1224|Proteobacteria,42SAW@68525|delta/epsilon subdivisions,2WP5F@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Putative MetA-pathway of phenol degradation - - - - - - - - - - - - - k59_84272_5 713586.KB900536_gene1929 1.93e-106 365.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - ko:K03556 - - - - ko00000,ko03000 - - - BTAD,GGDEF,TPR_12,TPR_8,Trans_reg_C k59_800063_1 1419583.V466_26410 3.33e-29 120.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1YNCX@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q Peptide synthetase pvdI - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD,Thioesterase k59_347350_1 1304883.KI912532_gene2157 9.88e-62 211.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,2KVCU@206389|Rhodocyclales 206389|Rhodocyclales T signal-transduction protein containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_49798_1 493475.GARC_3787 2.93e-19 87.8 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,464KJ@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair rapA GO:0000166,GO:0001000,GO:0003674,GO:0003676,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - Helicase_C,RapA_C,SNF2_N k59_84274_1 1165841.SULAR_05098 8.17e-30 114.0 COG0731@1|root,COG0731@2|Bacteria,1QG36@1224|Proteobacteria,42M82@68525|delta/epsilon subdivisions,2YN42@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM k59_84274_2 749222.Nitsa_1010 5.22e-61 196.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2YMPG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_542717_1 555778.Hneap_1764 1.3e-78 248.0 29IGX@1|root,32MKS@2|Bacteria,1RKR3@1224|Proteobacteria,1S8A0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_836132_1 1123253.AUBD01000009_gene2331 5.46e-43 143.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1X61V@135614|Xanthomonadales 135614|Xanthomonadales J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_836132_2 1245471.PCA10_10580 1.1e-45 150.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1YFU2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Ribosomal protein S9/S16 rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_575131_1 497321.C664_20063 4.45e-134 389.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,2KXY6@206389|Rhodocyclales 206389|Rhodocyclales L COG3039 Transposase and inactivated derivatives, IS5 family - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_901542_1 1124982.MSI_02220 1.21e-23 105.0 arCOG08054@1|root,2Z8AD@2|Bacteria,2J74M@203691|Spirochaetes 203691|Spirochaetes S Pfam:DUF4353 - - - - - - - - - - - - Cthe_2159 k59_1000123_1 1168034.FH5T_04325 2.44e-71 216.0 COG0629@1|root,COG0629@2|Bacteria,4NT9M@976|Bacteroidetes,2FS0P@200643|Bacteroidia 976|Bacteroidetes L COG NOG19098 non supervised orthologous group - - - - - - - - - - - - DUF3127 k59_1000123_2 927658.AJUM01000022_gene1009 1e-51 170.0 COG0545@1|root,COG0545@2|Bacteria,4NDW4@976|Bacteroidetes,2G31Y@200643|Bacteroidia,3XIKP@558415|Marinilabiliaceae 976|Bacteroidetes O Domain amino terminal to FKBP-type peptidyl-prolyl isomerase - - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_117344_1 1165841.SULAR_10099 1.3e-84 260.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2YMGD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_476220_1 522306.CAP2UW1_3683 2.3e-80 256.0 COG5433@1|root,COG5433@2|Bacteria,1MXI8@1224|Proteobacteria,2W66H@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Transposase, IS4-like - - - - - - - - - - - - - k59_673829_1 1442598.JABW01000012_gene395 9.86e-58 199.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,43DHS@68525|delta/epsilon subdivisions 1224|Proteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_347365_1 713587.THITH_15950 1.74e-116 352.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales 135613|Chromatiales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_967101_2 545264.KB898751_gene2596 5.75e-66 207.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1WX9V@135613|Chromatiales 135613|Chromatiales E TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_312366_1 1306174.JODP01000003_gene2171 8.74e-23 103.0 COG1226@1|root,COG1226@2|Bacteria,2GKPB@201174|Actinobacteria 201174|Actinobacteria P Castor and Pollux, part of voltage-gated ion channel - - - - - - - - - - - - Castor_Poll_mid,TrkA_N k59_575142_3 632518.Calow_1362 5.65e-31 124.0 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,42F6C@68295|Thermoanaerobacterales 186801|Clostridia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_411023_1 118161.KB235922_gene928 7.51e-154 446.0 COG1171@1|root,COG1171@2|Bacteria,1GC9C@1117|Cyanobacteria,3VIVG@52604|Pleurocapsales 1117|Cyanobacteria E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT_4,PALP k59_1000132_2 85643.Tmz1t_3009 1.22e-71 225.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KVFI@206389|Rhodocyclales 206389|Rhodocyclales S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_934770_2 572544.Ilyop_1361 2.79e-180 509.0 COG1494@1|root,COG1494@2|Bacteria,3796W@32066|Fusobacteria 32066|Fusobacteria G Bacterial fructose-1,6-bisphosphatase, glpX-encoded glpX - 3.1.3.11 ko:K02446 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX k59_934770_3 572544.Ilyop_1360 1.41e-41 144.0 28PW4@1|root,2ZCGH@2|Bacteria,379ZC@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_934770_4 469616.FMAG_00897 6.78e-116 348.0 COG0436@1|root,COG0436@2|Bacteria,378B3@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score - - - ko:K00841 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00525 R04467 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_934770_5 649747.HMPREF0083_03831 4.17e-71 228.0 COG2171@1|root,COG2171@2|Bacteria,1TQUJ@1239|Firmicutes,4H9KY@91061|Bacilli,26TDX@186822|Paenibacillaceae 91061|Bacilli E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate dapH - 2.3.1.117,2.3.1.89 ko:K00674,ko:K05822 ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230 M00016,M00525 R04364,R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - DapH_N,Hexapep k59_934770_6 1408439.JHXW01000006_gene915 1.91e-84 256.0 COG0289@1|root,COG0289@2|Bacteria,37A15@32066|Fusobacteria 32066|Fusobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_13905_1 572544.Ilyop_0817 1.29e-165 482.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process tuaB - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt_3,Polysacc_synt_C k59_737011_2 387093.SUN_1243 3.3e-44 157.0 COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria,43CEV@68525|delta/epsilon subdivisions,2YRH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_673840_1 880073.Calab_1785 1.95e-70 234.0 COG0709@1|root,COG1104@1|root,COG0709@2|Bacteria,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine selD - 2.7.9.3,2.8.1.7 ko:K01008,ko:K04487 ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122 - R03595,R07460,R11528,R11529 RC00002,RC01789,RC02313,RC02878 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - AIRS,AIRS_C,Aminotran_5 k59_608135_1 644282.Deba_2964 2.02e-28 108.0 COG2204@1|root,COG2204@2|Bacteria,1MYQ1@1224|Proteobacteria,42TBS@68525|delta/epsilon subdivisions,2WNQA@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_378687_1 765911.Thivi_4098 1.36e-53 172.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1WY5P@135613|Chromatiales 135613|Chromatiales J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_378687_2 1385515.N791_04915 8.71e-15 70.5 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1X6H0@135614|Xanthomonadales 135614|Xanthomonadales J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_13911_1 570417.WP0338 2.68e-78 246.0 COG3344@1|root,COG3344@2|Bacteria,1NB7T@1224|Proteobacteria,2UU48@28211|Alphaproteobacteria,47GDS@766|Rickettsiales 766|Rickettsiales L reverse transcriptase - - - - - - - - - - - - - k59_84316_1 1089549.AZUQ01000001_gene1304 3.46e-42 158.0 COG3534@1|root,COG3534@2|Bacteria,2HFI6@201174|Actinobacteria,4EZ48@85014|Glycomycetales 201174|Actinobacteria G Alpha-L-arabinofuranosidase C-terminus - - - - - - - - - - - - Alpha-L-AF_C,CBM_4_9 k59_705620_1 1049564.TevJSym_as00290 1.06e-05 43.9 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_705620_2 1123367.C666_00340 2.05e-54 176.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,2KWHT@206389|Rhodocyclales 206389|Rhodocyclales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_705620_3 1163408.UU9_02808 2.39e-15 77.0 COG0477@1|root,COG0477@2|Bacteria,1R9KU@1224|Proteobacteria,1T4K2@1236|Gammaproteobacteria,1XDAH@135614|Xanthomonadales 135614|Xanthomonadales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_183639_1 572265.HDEF_0103 4.47e-55 195.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,282ZU@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria L Helicase associated domain (HA2) Add an annotation hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1032510_1 396588.Tgr7_1275 6.05e-41 144.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1WWD8@135613|Chromatiales 135613|Chromatiales O Belongs to the HypD family - - - ko:K04654 - - - - ko00000 - - - HypD k59_1032510_2 1121406.JAEX01000001_gene421 9.22e-21 94.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2M8IT@213115|Desulfovibrionales 28221|Deltaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - iAF987.Gmet_0119 Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1032512_1 1158292.JPOE01000002_gene1439 1.17e-85 281.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1KJ1Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_771596_1 1348657.M622_16960 5.11e-55 194.0 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VPRW@28216|Betaproteobacteria 28216|Betaproteobacteria M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_543537_1 1265505.ATUG01000001_gene3101 3.81e-199 562.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,2MJ8E@213118|Desulfobacterales 28221|Deltaproteobacteria P Domain of unknown function (DUF3333) pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_543537_2 177437.HRM2_01750 1.89e-202 575.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MHPU@213118|Desulfobacterales 28221|Deltaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_543537_3 1121403.AUCV01000001_gene703 2.6e-178 504.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,42MJ3@68525|delta/epsilon subdivisions,2WKD5@28221|Deltaproteobacteria,2MHQC@213118|Desulfobacterales 28221|Deltaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_543537_4 1049564.TevJSym_ax00030 1.06e-141 416.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1J4K9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase phoR GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_543537_5 1049564.TevJSym_ax00020 9.31e-109 319.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1J5E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoB GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_543537_6 1116472.MGMO_143c00070 2.29e-27 103.0 2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,1SD8N@1236|Gammaproteobacteria,1XFAR@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF2782) - - - - - - - - - - - - DUF2782 k59_543537_7 1049564.TevJSym_as00420 8.23e-117 339.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria,1J5SE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_14785_1 75379.Tint_3137 1.34e-59 194.0 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,1KJJ5@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_151813_1 1198232.CYCME_0697 4.95e-75 252.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,45ZMV@72273|Thiotrichales 72273|Thiotrichales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_2,OstA_C k59_575979_1 1121875.KB907546_gene2203 1.88e-31 119.0 COG2367@1|root,COG2367@2|Bacteria,4NE3C@976|Bacteroidetes,1HZYJ@117743|Flavobacteriia 976|Bacteroidetes V beta-lactamase per1 - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_411832_1 1118054.CAGW01000091_gene3558 7.24e-46 155.0 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,4HFQD@91061|Bacilli,26QS7@186822|Paenibacillaceae 91061|Bacilli J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_379603_1 1292034.OR37_00810 5.78e-15 77.4 COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,2TSK9@28211|Alphaproteobacteria,2KG3M@204458|Caulobacterales 204458|Caulobacterales P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_379603_2 977880.RALTA_A0177 4.64e-34 130.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1K183@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the GMC oxidoreductase family - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,Lycopene_cycl k59_706455_1 929558.SMGD1_2188 2.63e-126 372.0 COG0579@1|root,COG0579@2|Bacteria,1MUCC@1224|Proteobacteria,42M2Q@68525|delta/epsilon subdivisions,2YMYG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Malate quinone- oxidoreductase mqo GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.5.4 ko:K00116 ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R00360,R00361,R01257 RC00031 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0086 Mqo k59_543544_1 225937.HP15_862 2.13e-12 68.9 COG2199@1|root,COG2200@1|root,COG3710@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG3710@2|Bacteria,1RGCV@1224|Proteobacteria,1T3BM@1236|Gammaproteobacteria,469XC@72275|Alteromonadaceae 1236|Gammaproteobacteria T Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631,EAL,GGDEF k59_543544_2 1260251.SPISAL_08290 1.01e-78 256.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales 135613|Chromatiales L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1032539_1 631362.Thi970DRAFT_04271 3.09e-120 361.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales 135613|Chromatiales O PFAM Magnesium chelatase, ChlI subunit - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1001018_1 1165841.SULAR_05128 9.17e-85 273.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2YMS4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_118275_1 1173028.ANKO01000114_gene6161 1.4e-10 68.9 COG3299@1|root,COG3299@2|Bacteria,1G006@1117|Cyanobacteria,1H9YU@1150|Oscillatoriales 1117|Cyanobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_902361_1 469616.FMAG_00868 5.88e-133 394.0 COG0168@1|root,COG0168@2|Bacteria,37893@32066|Fusobacteria 32066|Fusobacteria P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_902361_2 1540257.JQMW01000002_gene1370 8.26e-13 67.4 COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,36DGN@31979|Clostridiaceae 186801|Clostridia P Potassium uptake protein ktrC - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_641584_1 1125863.JAFN01000001_gene3078 9.39e-60 203.0 COG0614@1|root,COG1865@1|root,COG0614@2|Bacteria,COG1865@2|Bacteria,1QYTY@1224|Proteobacteria,42NSI@68525|delta/epsilon subdivisions,2WKZP@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Adenosylcobinamide amidohydrolase - - - - - - - - - - - - CbiZ,Peripla_BP_2 k59_869275_1 379066.GAU_0382 2.27e-33 134.0 COG5001@1|root,COG5001@2|Bacteria,1ZT12@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS k59_85150_1 572477.Alvin_2382 1.18e-180 508.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1WWSB@135613|Chromatiales 135613|Chromatiales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_85150_2 1121921.KB898714_gene1819 2.26e-70 220.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,2PN57@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Ribosomal L25p family ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_85150_3 1249627.D779_0928 1.82e-79 242.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1WWEP@135613|Chromatiales 135613|Chromatiales J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_807116_3 1157490.EL26_19265 8.22e-62 201.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H9S9@91061|Bacilli,277XD@186823|Alicyclobacillaceae 91061|Bacilli J Metallopeptidase family M24 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_482611_1 1049564.TevJSym_ah00460 1.17e-81 264.0 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_57029_1 264198.Reut_A0313 2.48e-06 52.8 COG5488@1|root,COG5488@2|Bacteria,1N5Z9@1224|Proteobacteria,2VU1W@28216|Betaproteobacteria,1K6XS@119060|Burkholderiaceae 28216|Betaproteobacteria S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_743906_1 765910.MARPU_12910 1.54e-16 83.2 COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,1WYDK@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4115) - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_743906_2 396588.Tgr7_2050 7.27e-09 59.7 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1WWUQ@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus biogenesis stability protein PilW - - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - LysM,TPR_10,TPR_14,TPR_16,TPR_17,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_417747_1 160488.PP_3425 2.33e-21 96.7 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RMI7@1236|Gammaproteobacteria,1YX4M@136845|Pseudomonas putida group 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mexE - - ko:K18298 - M00641 - - ko00000,ko00002,ko01504,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_223115_2 1150600.ADIARSV_4228 1.79e-08 53.5 2EFZ5@1|root,339RB@2|Bacteria,4NXH9@976|Bacteroidetes,1IUJI@117747|Sphingobacteriia 976|Bacteroidetes S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 k59_223115_3 1168034.FH5T_08940 1.09e-26 101.0 COG1664@1|root,COG1664@2|Bacteria,4NUZA@976|Bacteroidetes,2FUPU@200643|Bacteroidia 976|Bacteroidetes M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_387543_2 1168034.FH5T_05155 1.09e-214 599.0 COG3474@1|root,COG3474@2|Bacteria,4PKQA@976|Bacteroidetes 976|Bacteroidetes C Quinol cytochrome c oxidoreductase - - - - - - - - - - - - Cytochrom_C,Cytochrom_CIII,Cytochrome_C7 k59_22316_1 387092.NIS_1142 4.75e-73 233.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2YMCD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN2 - - - - - - - - - - - Radical_SAM k59_452089_1 768706.Desor_2581 5.17e-105 313.0 COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,2645A@186807|Peptococcaceae 186801|Clostridia C Iron-containing alcohol dehydrogenase - - - ko:K19955 - - - - ko00000,ko01000 - - - Fe-ADH k59_354927_1 575586.HMPREF0016_00661 1.67e-94 293.0 COG1637@1|root,COG1637@2|Bacteria,1Q97I@1224|Proteobacteria,1S0BW@1236|Gammaproteobacteria,3NMRN@468|Moraxellaceae 1236|Gammaproteobacteria L nuclease of the RecB family - - - - - - - - - - - - - k59_58243_1 563040.Saut_0928 6.29e-66 221.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YR2T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG1033 exporter of the RND superfamily protein - - - ko:K07003 - - - - ko00000 - - - MMPL k59_191698_1 1123248.KB893324_gene1660 2.35e-74 244.0 COG5434@1|root,COG5434@2|Bacteria,4NDWX@976|Bacteroidetes,1IR1S@117747|Sphingobacteriia 976|Bacteroidetes M Parallel beta-helix repeats - - - - - - - - - - - - Beta_helix k59_58245_1 644282.Deba_2308 3.75e-64 204.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,42PR1@68525|delta/epsilon subdivisions,2WIQ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria N PFAM MotA TolQ ExbB proton channel - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_452097_1 572544.Ilyop_0481 1.65e-181 515.0 COG0502@1|root,COG0502@2|Bacteria,3785Y@32066|Fusobacteria 32066|Fusobacteria C Biotin and Thiamin Synthesis associated domain hydG - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM k59_1007909_1 754476.Q7A_2562 5.37e-20 93.2 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,460N9@72273|Thiotrichales 72273|Thiotrichales NU TIGRFAM type IV pilus biogenesis stability protein PilW - - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - TPR_2,TPR_8 k59_519436_1 1278307.KB906980_gene4115 4.82e-34 133.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RRFS@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014,ko:K16089 - - - - ko00000,ko02000 1.B.14,1.B.14.1,1.B.14.10 - - Plug,TonB_dep_Rec k59_354936_2 1219049.SP5_068_00270 1.37e-71 239.0 COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PKD k59_942789_1 749927.AMED_3075 1.01e-80 246.0 COG5297@1|root,COG5297@2|Bacteria,2HDPZ@201174|Actinobacteria,4E0P2@85010|Pseudonocardiales 201174|Actinobacteria G Glycosyl hydrolase family 12 - - - - - - - - - - - - Glyco_hydro_12 k59_387563_1 84531.JMTZ01000036_gene458 1.3e-15 79.3 COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,1RSI6@1236|Gammaproteobacteria,1X9G8@135614|Xanthomonadales 135614|Xanthomonadales I Enoyl-CoA hydratase/isomerase - - - ko:K13816 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001 - - - ECH_1 k59_452109_2 1249997.JHZW01000003_gene2650 3.78e-54 177.0 COG1794@1|root,COG1794@2|Bacteria,4NM9B@976|Bacteroidetes,1I13P@117743|Flavobacteriia,2PHKE@252356|Maribacter 976|Bacteroidetes M Asp/Glu/Hydantoin racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_1040222_1 588581.Cpap_0010 4.92e-106 348.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria 2|Bacteria IQ oxidoreductase activity - - - ko:K13612,ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - ADH_N,ADH_zinc_N,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_583444_1 1384056.N787_11465 3.78e-30 119.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1X3T3@135614|Xanthomonadales 135614|Xanthomonadales EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_583444_2 646529.Desaci_4535 2.63e-09 57.4 COG0334@1|root,COG0334@2|Bacteria,1TR4Z@1239|Firmicutes,25CDT@186801|Clostridia 186801|Clostridia C Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_452114_1 1168034.FH5T_21980 1.84e-52 184.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,2FN1K@200643|Bacteroidia 976|Bacteroidetes EU Peptidase, S9A B C family, catalytic domain protein pop GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - PD40,Peptidase_S9 k59_778924_1 1537917.JU82_07235 5.98e-117 345.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2YMMP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the peptidase M16 family pqqL - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_778924_2 929558.SMGD1_2515 1.45e-171 486.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2YMYR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD - 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_452116_1 1288963.ADIS_0470 6.97e-107 326.0 COG1082@1|root,COG1082@2|Bacteria,4NEWC@976|Bacteroidetes,47NAD@768503|Cytophagia 976|Bacteroidetes G Glycosyl-hydrolase 97 C-terminal, oligomerisation - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - GH97_C,GH97_N,Glyco_hydro_97 k59_942804_1 1249627.D779_3259 2.19e-94 294.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1WWJU@135613|Chromatiales 135613|Chromatiales H PFAM Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_22352_1 105559.Nwat_2215 4.72e-39 149.0 COG1256@1|root,COG1749@1|root,COG1256@2|Bacteria,COG1749@2|Bacteria,1MV2M@1224|Proteobacteria,1RMEA@1236|Gammaproteobacteria,1WW11@135613|Chromatiales 135613|Chromatiales N TIGRFAM Flagellar hook-associated protein, FlgK flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_92786_1 457415.HMPREF1006_01076 1.69e-16 83.2 COG1450@1|root,COG1450@2|Bacteria,3TA72@508458|Synergistetes 508458|Synergistetes NU General secretion pathway protein - - - - - - - - - - - - Secretin,Secretin_N k59_843771_1 387093.SUN_2354 9.05e-112 341.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,42MWP@68525|delta/epsilon subdivisions,2YNEC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Oxidoreductase - - 1.1.99.3 ko:K06151 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_224033_1 754477.Q7C_1794 1.69e-61 205.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,45ZP9@72273|Thiotrichales 72273|Thiotrichales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_387585_1 96561.Dole_1813 1.39e-31 119.0 COG1373@1|root,COG1373@2|Bacteria,1NQGE@1224|Proteobacteria,42R19@68525|delta/epsilon subdivisions,2WMNW@28221|Deltaproteobacteria,2MMR8@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4143) - - - - - - - - - - - - AAA_14,DUF4143 k59_648880_1 1454004.AW11_01686 6.42e-69 229.0 COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,2VPV7@28216|Betaproteobacteria 28216|Betaproteobacteria K Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_22362_1 637389.Acaty_c0017 1.57e-16 88.2 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,2NCHT@225057|Acidithiobacillales 225057|Acidithiobacillales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_319920_1 1168034.FH5T_02845 5.75e-101 303.0 COG0842@1|root,COG0842@2|Bacteria,4NDU0@976|Bacteroidetes,2FMJ3@200643|Bacteroidia 976|Bacteroidetes V Transport permease protein ybhS - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_287312_1 446466.Cfla_0779 4.32e-54 181.0 COG4992@1|root,COG4992@2|Bacteria,2GK0J@201174|Actinobacteria,4F29B@85016|Cellulomonadaceae 201174|Actinobacteria E Aminotransferase class-III rocD - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_807922_1 1123065.ATWL01000005_gene1253 1e-81 253.0 COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria 201174|Actinobacteria F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - iNJ661.Rv3313c A_deaminase k59_616176_1 1500890.JQNL01000001_gene1049 6.29e-16 78.2 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1X2Y9@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_616176_2 1049564.TevJSym_ba00070 1.34e-48 157.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1J63S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iJN746.PP_1602 FabA k59_681900_1 1168034.FH5T_11415 4.77e-153 441.0 COG0044@1|root,COG0044@2|Bacteria,4NE3T@976|Bacteroidetes,2FN4X@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_519495_1 1128421.JAGA01000002_gene331 7.8e-49 174.0 COG0442@1|root,COG0442@2|Bacteria,2NNNH@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_942856_1 1177179.A11A3_01150 1.45e-106 320.0 COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Alkane 1-monooxygenase alkB1 GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016713,GO:0018685,GO:0043446,GO:0043448,GO:0044237,GO:0044248,GO:0055114,GO:0071704,GO:1901575 1.14.15.3 ko:K00496 ko00071,ko00930,map00071,map00930 - R01347,R02281,R06945 RC00478 ko00000,ko00001,ko01000 - - - FA_desaturase k59_418667_1 413404.Rmag_0862 3.9e-15 73.9 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster dsrL - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,NADH_4Fe-4S,Pyr_redox_2 k59_418667_2 1123400.KB904780_gene1910 1.43e-29 112.0 2E6CU@1|root,3310G@2|Bacteria,1NBK1@1224|Proteobacteria,1S5EP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - dsrJ - - - - - - - - - - - - k59_1040265_1 411476.BACOVA_00550 2.02e-06 47.8 COG4430@1|root,COG4430@2|Bacteria,4NWI7@976|Bacteroidetes,2FN25@200643|Bacteroidia,4AN4M@815|Bacteroidaceae 976|Bacteroidetes S protein conserved in bacteria - - - - - - - - - - - - OmdA k59_1040265_2 1296415.JACC01000105_gene2891 1.16e-49 169.0 COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,1HZYN@117743|Flavobacteriia,2YJXM@290174|Aquimarina 976|Bacteroidetes L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_807943_1 472759.Nhal_1056 2.97e-92 282.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales 135613|Chromatiales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_92828_1 1168034.FH5T_18950 1.82e-35 134.0 COG0706@1|root,COG0706@2|Bacteria,4NESJ@976|Bacteroidetes,2FN3A@200643|Bacteroidia 976|Bacteroidetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_452201_1 1499967.BAYZ01000033_gene1092 6.79e-38 140.0 COG2006@1|root,COG2006@2|Bacteria,2NPTK@2323|unclassified Bacteria 2|Bacteria C Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362,Fer4 k59_1007977_1 1203606.HMPREF1526_00764 1.4e-59 204.0 COG4146@1|root,COG4146@2|Bacteria,1UHPR@1239|Firmicutes,24QXT@186801|Clostridia,36FAM@31979|Clostridiaceae 186801|Clostridia S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_92830_1 335543.Sfum_1366 1.74e-41 151.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2MQ68@213462|Syntrophobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_22413_1 1041159.AZUW01000062_gene3637 4.61e-12 75.5 COG1404@1|root,COG1404@2|Bacteria,1PSEZ@1224|Proteobacteria,2V4M5@28211|Alphaproteobacteria,4BFDK@82115|Rhizobiaceae 28211|Alphaproteobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_319947_1 3702.ATCG00340.1 0.0 922.0 28JJ8@1|root,2QRYE@2759|Eukaryota,37QY5@33090|Viridiplantae,3GH5Y@35493|Streptophyta,3I1XS@3699|Brassicales 35493|Streptophyta C PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin psaB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009941,GO:0010287,GO:0016020,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 - ko:K02690 ko00195,ko01100,map00195,map01100 M00163 - - ko00000,ko00001,ko00002,ko00194 - - - PsaA_PsaB k59_191786_2 1131269.AQVV01000030_gene281 1.94e-56 198.0 COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria 2|Bacteria T Gaf domain - - 4.6.1.1 ko:K01768,ko:K04769 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03000 - - - AAA_35,GAF,GAF_2,Guanylate_cyc,PAS,PAS_4,PAS_8,PAS_9 k59_224105_1 1237149.C900_01278 8.39e-34 130.0 COG0358@1|root,COG0358@2|Bacteria,4P46J@976|Bacteroidetes,47YPU@768503|Cytophagia 976|Bacteroidetes L Toprim-like - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_255928_1 1121017.AUFG01000020_gene2315 4.7e-07 57.4 COG3021@1|root,COG3021@2|Bacteria,2GKXC@201174|Actinobacteria,4FH37@85021|Intrasporangiaceae 201174|Actinobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_974797_2 335543.Sfum_1181 1.01e-52 180.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_778990_1 713587.THITH_02145 3.29e-47 162.0 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria P DNA binding domain - - - - - - - - - - - - HTH_17,PBP_like k59_843828_1 199310.c1025 3.76e-18 82.4 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,3XNJ5@561|Escherichia 1236|Gammaproteobacteria O Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - iPC815.YPO1374 Pyr_redox_2 k59_843828_2 8479.XP_005278959.1 2.69e-52 176.0 COG0084@1|root,KOG3020@2759|Eukaryota,38GNW@33154|Opisthokonta,3BDHE@33208|Metazoa,3CZ5B@33213|Bilateria,4809E@7711|Chordata,48UZV@7742|Vertebrata,4C94Q@8459|Testudines 33208|Metazoa L TatD DNase domain containing 3 TATDN3 - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_681930_1 1177154.Y5S_01822 3.6e-103 332.0 COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,1RZXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria L AAA domain - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,PDDEXK_1,RNase_H_2 k59_519527_1 765911.Thivi_1736 2.64e-79 240.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales 135613|Chromatiales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_519527_2 626887.J057_05031 2.69e-37 134.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,465QJ@72275|Alteromonadaceae 1236|Gammaproteobacteria D Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_778992_1 2340.JV46_25860 1.56e-48 159.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1J6PQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF494) smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_319962_2 563040.Saut_0233 1.62e-62 194.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,42SRC@68525|delta/epsilon subdivisions,2YP4I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_681934_1 1487921.DP68_18465 4.19e-93 282.0 COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,36E3S@31979|Clostridiaceae 186801|Clostridia E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_319965_1 1415779.JOMH01000001_gene1474 3.69e-73 241.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1X3GA@135614|Xanthomonadales 135614|Xanthomonadales P Heavy metal translocating P-type atpase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_459229_1 1168034.FH5T_13605 3.74e-130 390.0 COG1048@1|root,COG1048@2|Bacteria,4NDZT@976|Bacteroidetes,2FMDQ@200643|Bacteroidia 976|Bacteroidetes C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_524523_1 59196.RICGR_0656 6.28e-54 175.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1JD0V@118969|Legionellales 118969|Legionellales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_7 k59_524523_2 1049564.TevJSym_ap00530 4.46e-75 231.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S4ZA@1236|Gammaproteobacteria,1JBRZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_524523_3 396588.Tgr7_0996 1.23e-47 154.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,1WYHG@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_524523_4 1049564.TevJSym_ap00510 0.0 1022.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341,ko:K05559 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_524523_5 1049564.TevJSym_ap00500 4.54e-309 848.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J5MF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH ubiquinone oxidoreductase subunit nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_524523_6 1049564.TevJSym_ap00490 2.5e-151 441.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1J5NF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_295663_1 338966.Ppro_1908 5.78e-36 127.0 2DW9N@1|root,33Z70@2|Bacteria,1NYS0@1224|Proteobacteria,430E6@68525|delta/epsilon subdivisions,2WW01@28221|Deltaproteobacteria 28221|Deltaproteobacteria S ParB-like nuclease domain - - - - - - - - - - - - ParBc k59_262727_3 1227349.C170_28033 3.37e-32 124.0 COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,4H9Y4@91061|Bacilli,26QU9@186822|Paenibacillaceae 91061|Bacilli J seryl-tRNA synthetase serS3 - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_132242_1 1168034.FH5T_16855 1.86e-29 114.0 COG0124@1|root,COG0124@2|Bacteria,4NE8N@976|Bacteroidetes,2FM6I@200643|Bacteroidia 976|Bacteroidetes J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_132242_2 1168034.FH5T_16830 3.32e-75 227.0 COG1956@1|root,COG1956@2|Bacteria,4NM6D@976|Bacteroidetes,2FS26@200643|Bacteroidia 976|Bacteroidetes T GAF domain-containing protein msrC - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF,GAF_2 k59_818670_1 1168034.FH5T_13105 6.67e-108 342.0 COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes,2FPXW@200643|Bacteroidia 976|Bacteroidetes E Peptidase, S9A B C family, catalytic domain protein - - - - - - - - - - - - Peptidase_S9 k59_230376_1 525373.HMPREF0766_13232 1.92e-18 90.1 COG2207@1|root,COG2207@2|Bacteria,4NJPM@976|Bacteroidetes,1IXKH@117747|Sphingobacteriia 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - AraC_binding,HTH_18 k59_230376_2 1123057.P872_20960 6.31e-54 172.0 2E4PM@1|root,32P93@2|Bacteria,4NRUB@976|Bacteroidetes,47VK6@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_230376_3 1187851.A33M_4288 1.53e-61 196.0 28NRA@1|root,2ZBQK@2|Bacteria,1RASY@1224|Proteobacteria 1224|Proteobacteria S Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_753260_1 933262.AXAM01000029_gene2741 2.63e-09 58.5 COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria,2MIVJ@213118|Desulfobacterales 28221|Deltaproteobacteria C Fe-S cluster domain protein - - - - - - - - - - - - FeS,Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3 k59_753260_2 1121405.dsmv_3392 1.18e-99 293.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,42MCM@68525|delta/epsilon subdivisions,2WKRE@28221|Deltaproteobacteria,2MJ7J@213118|Desulfobacterales 28221|Deltaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_753260_3 1265505.ATUG01000002_gene2206 2.41e-40 139.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,42NVB@68525|delta/epsilon subdivisions,2WK6R@28221|Deltaproteobacteria,2MINN@213118|Desulfobacterales 28221|Deltaproteobacteria C Part of a membrane complex involved in electron transport rnfE - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_491793_1 32057.KB217483_gene9456 6.55e-81 251.0 COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,1HJR6@1161|Nostocales 1117|Cyanobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_949493_1 927658.AJUM01000047_gene2986 7.19e-71 222.0 COG2273@1|root,COG2273@2|Bacteria,4NHP5@976|Bacteroidetes,2FP9D@200643|Bacteroidia,3XJWJ@558415|Marinilabiliaceae 976|Bacteroidetes G Glycosyl hydrolases family 16 bglA - - - - - - - - - - - GDPD,Glyco_hydro_16 k59_1175_2 96561.Dole_2880 3.16e-57 183.0 COG4871@1|root,COG4871@2|Bacteria,1RF0E@1224|Proteobacteria,42RKU@68525|delta/epsilon subdivisions,2WNHT@28221|Deltaproteobacteria,2MK4I@213118|Desulfobacterales 28221|Deltaproteobacteria C Putative Fe-S cluster - - - - - - - - - - - - FeS k59_589946_1 929558.SMGD1_2539 4.05e-134 395.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2YMFV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_916869_1 946362.XP_004990690.1 1.55e-16 86.3 KOG3594@1|root,KOG1219@2759|Eukaryota,KOG3594@2759|Eukaryota,KOG4289@2759|Eukaryota,38CZH@33154|Opisthokonta 33154|Opisthokonta M condensed mesenchymal cell proliferation - GO:0000902,GO:0000904,GO:0001654,GO:0001736,GO:0001738,GO:0001745,GO:0001751,GO:0001754,GO:0002009,GO:0003674,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0006935,GO:0007155,GO:0007156,GO:0007163,GO:0007164,GO:0007275,GO:0007389,GO:0007399,GO:0007409,GO:0007411,GO:0007423,GO:0008150,GO:0009605,GO:0009653,GO:0009887,GO:0009888,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016049,GO:0016318,GO:0016339,GO:0022008,GO:0022610,GO:0030030,GO:0030154,GO:0030182,GO:0031175,GO:0031224,GO:0031226,GO:0032501,GO:0032502,GO:0032989,GO:0032990,GO:0040007,GO:0040011,GO:0042051,GO:0042067,GO:0042221,GO:0042330,GO:0042461,GO:0042462,GO:0043167,GO:0043169,GO:0044331,GO:0044425,GO:0044459,GO:0044464,GO:0045463,GO:0045465,GO:0045466,GO:0045467,GO:0046530,GO:0046872,GO:0048468,GO:0048513,GO:0048588,GO:0048589,GO:0048592,GO:0048666,GO:0048667,GO:0048675,GO:0048699,GO:0048729,GO:0048731,GO:0048749,GO:0048812,GO:0048846,GO:0048856,GO:0048858,GO:0048869,GO:0050896,GO:0060429,GO:0060560,GO:0061564,GO:0071840,GO:0071944,GO:0090596,GO:0097485,GO:0098609,GO:0098742,GO:0120036,GO:0120039,GO:1902284,GO:1990138 - ko:K16506,ko:K16507,ko:K16669 ko04391,ko04392,map04391,map04392 - - - ko00000,ko00001,ko04147,ko04516 - - - Cadherin,Cadherin_C,EGF,Kunitz_BPTI,Laminin_G_2,TMEM132 k59_982017_2 1121085.AUCI01000004_gene1887 1.33e-07 55.5 COG1734@1|root,COG1734@2|Bacteria,1V6MF@1239|Firmicutes,4HEPK@91061|Bacilli,1ZEEI@1386|Bacillus 91061|Bacilli T COG1734 DnaK suppressor protein yteA - - - - - - - - - - - zf-dskA_traR k59_982017_4 2754.EH55_09555 3.65e-50 183.0 COG1185@1|root,COG1185@2|Bacteria,3T9RU@508458|Synergistetes 508458|Synergistetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_459249_1 713586.KB900536_gene1139 9.98e-106 318.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_99556_1 1168034.FH5T_05025 3.53e-159 474.0 COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,2FM01@200643|Bacteroidia 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_753263_2 994573.T472_0204370 4.39e-22 87.8 COG4430@1|root,COG4430@2|Bacteria,1VFRR@1239|Firmicutes,256A5@186801|Clostridia 186801|Clostridia S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - OmdA k59_753263_3 97137.C821_00728 1.46e-36 140.0 COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,4HB1H@91061|Bacilli,3F4CF@33958|Lactobacillaceae 91061|Bacilli K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth sigA - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_262736_1 598659.NAMH_0699 2.89e-24 100.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2YMS3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_262736_2 598659.NAMH_1593 1.32e-47 155.0 COG1393@1|root,COG1393@2|Bacteria,1PPAE@1224|Proteobacteria,42SIG@68525|delta/epsilon subdivisions,2YSZ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ArsC family - - - - - - - - - - - - ArsC k59_720705_2 1121324.CLIT_5c00670 4.48e-181 515.0 COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,25SAM@186804|Peptostreptococcaceae 186801|Clostridia E Cleaves the N-terminal amino acid of tripeptides pepT - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M42 k59_622585_1 572544.Ilyop_1265 3.1e-117 354.0 COG2812@1|root,COG2812@2|Bacteria,378A7@32066|Fusobacteria 32066|Fusobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_687998_1 1408813.AYMG01000013_gene1170 3.02e-60 206.0 COG3589@1|root,COG3589@2|Bacteria,4NE7B@976|Bacteroidetes,1IP2A@117747|Sphingobacteriia 976|Bacteroidetes S PFAM glycoside hydrolase - - - - - - - - - - - - GH97_C,GH97_N,Glyco_hydro_97 k59_295686_1 326298.Suden_0088 2.18e-69 237.0 COG2887@1|root,COG2887@2|Bacteria,1QUIU@1224|Proteobacteria,42M7I@68525|delta/epsilon subdivisions,2YMX0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG3893 inactivated superfamily I helicase addB - - - - - - - - - - - PDDEXK_1 k59_99566_1 1511.CLOST_1630 1.25e-05 51.2 COG1409@1|root,COG1409@2|Bacteria,1UQCQ@1239|Firmicutes,248P1@186801|Clostridia,25RJD@186804|Peptostreptococcaceae 186801|Clostridia S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_557371_1 929558.SMGD1_0543 1.1e-117 356.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2YMB1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iIT341.HP1532 GATase_6,SIS k59_197644_1 572544.Ilyop_0437 5.1e-130 379.0 COG3872@1|root,COG3872@2|Bacteria,378KA@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - DUF1385 k59_230405_1 1121405.dsmv_0964 1.41e-53 182.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WJI9@28221|Deltaproteobacteria,2MHSD@213118|Desulfobacterales 28221|Deltaproteobacteria LU TIGRFAM DNA protecting protein DprA dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_851526_1 709032.Sulku_0587 4.89e-193 554.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_851526_3 709032.Sulku_0585 1.46e-116 355.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C k59_1192_1 485917.Phep_0903 1.7e-89 275.0 COG3177@1|root,COG3177@2|Bacteria,4NHFY@976|Bacteroidetes,1IV77@117747|Sphingobacteriia 976|Bacteroidetes K Fic/DOC family - - - - - - - - - - - - Fic,HTH_24,HTH_DeoR k59_459859_1 1319815.HMPREF0202_02679 3.74e-12 72.4 COG0845@1|root,COG0845@2|Bacteria,37956@32066|Fusobacteria 32066|Fusobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_D23,OEP k59_296197_1 387093.SUN_0687 5.16e-89 290.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2YNKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_165596_1 1286171.EAL2_c19280 3.04e-87 273.0 COG1541@1|root,COG1541@2|Bacteria,1UYWT@1239|Firmicutes,2496I@186801|Clostridia,25X9F@186806|Eubacteriaceae 186801|Clostridia H coenzyme F390 synthetase - - - - - - - - - - - - AMP-binding k59_165596_2 1173020.Cha6605_5163 3.99e-37 140.0 COG3000@1|root,COG3000@2|Bacteria,1G7RK@1117|Cyanobacteria 1117|Cyanobacteria I PFAM Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_165596_3 714943.Mucpa_6952 3.37e-07 49.3 COG3462@1|root,COG3462@2|Bacteria,4NVJQ@976|Bacteroidetes,1ITX7@117747|Sphingobacteriia 976|Bacteroidetes S membrane protein (DUF2078) - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_165596_5 913865.DOT_2300 0.000286 43.5 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,264AB@186807|Peptococcaceae 186801|Clostridia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_165596_6 697282.Mettu_1699 2.25e-06 48.9 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XFYJ@135618|Methylococcales 135618|Methylococcales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF,GGDEF,PAS_4,PAS_9 k59_132899_1 1384054.N790_04740 3.9e-97 296.0 COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,1RPY3@1236|Gammaproteobacteria,1X3FQ@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_688560_1 688269.Theth_1354 3.51e-81 249.0 COG2220@1|root,COG2220@2|Bacteria,2GC31@200918|Thermotogae 200918|Thermotogae S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 k59_1015328_1 768671.ThimaDRAFT_1939 3.86e-89 273.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1T5B6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_786504_1 392500.Swoo_2899 7.24e-66 213.0 COG3137@1|root,COG3137@2|Bacteria,1RCKQ@1224|Proteobacteria,1S0GK@1236|Gammaproteobacteria,2QA2B@267890|Shewanellaceae 1236|Gammaproteobacteria M Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 k59_525154_1 439235.Dalk_3276 1.81e-79 249.0 COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,42UTS@68525|delta/epsilon subdivisions,2WQM7@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_558056_1 443143.GM18_2915 1.04e-225 650.0 COG0553@1|root,COG0553@2|Bacteria,1MX26@1224|Proteobacteria,42P4C@68525|delta/epsilon subdivisions,2WKB5@28221|Deltaproteobacteria 28221|Deltaproteobacteria KL PFAM helicase domain protein - - - - - - - - - - - - Helicase_C,ResIII k59_884404_2 34506.g2124 2.63e-21 100.0 COG0617@1|root,KOG2159@2759|Eukaryota,398RN@33154|Opisthokonta,3BUWH@33208|Metazoa 33208|Metazoa J Probable RNA and SrmB- binding site of polymerase A - - - - - - - - - - - - PolyA_pol,PolyA_pol_RNAbd k59_753693_1 203119.Cthe_0408 7.86e-109 349.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3WGTE@541000|Ruminococcaceae 186801|Clostridia T Putative diguanylate phosphodiesterase - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - EAL,GGDEF,HisKA_7TM,PAS_3,PAS_9,SBP_bac_3 k59_753693_2 358681.BBR47_56660 9.49e-169 488.0 COG1455@1|root,COG1455@2|Bacteria,1TP8D@1239|Firmicutes,4H9W2@91061|Bacilli,26SNV@186822|Paenibacillaceae 91061|Bacilli G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane licC - - ko:K02761 ko00500,ko02060,map00500,map02060 M00275 R11170,R11172 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.3.2 - iYO844.BSU38390 PTS_EIIC k59_753693_3 1499684.CCNP01000022_gene2985 1.15e-124 363.0 COG0561@1|root,COG0561@2|Bacteria,1UFDJ@1239|Firmicutes,25B6S@186801|Clostridia,36WIT@31979|Clostridiaceae 186801|Clostridia S haloacid dehalogenase-like hydrolase - - - - - - - - - - - - Hydrolase_3 k59_753693_4 1294142.CINTURNW_2686 1.16e-112 332.0 COG0561@1|root,COG0561@2|Bacteria,1UYC4@1239|Firmicutes,24CIE@186801|Clostridia,36G20@31979|Clostridiaceae 186801|Clostridia S hydrolase - - - - - - - - - - - - Hydrolase_3 k59_753693_5 1499689.CCNN01000011_gene2977 4.27e-252 700.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,36EXF@31979|Clostridiaceae 186801|Clostridia G family 4 - - 3.2.1.86 ko:K01222 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT4 - Glyco_hydro_4,Glyco_hydro_4C k59_1532_1 85643.Tmz1t_0683 2.22e-23 93.2 2E5GP@1|root,3308B@2|Bacteria,1N858@1224|Proteobacteria,2VW3P@28216|Betaproteobacteria,2KXA9@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_296202_1 864051.BurJ1DRAFT_0974 1.95e-57 201.0 28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,2VPEJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_132905_1 933262.AXAM01000048_gene2601 1.41e-51 182.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_492450_2 385682.AFSL01000008_gene2615 2.68e-18 81.3 COG1259@1|root,COG1259@2|Bacteria,4NGSW@976|Bacteroidetes,2FTKZ@200643|Bacteroidia,3XJVC@558415|Marinilabiliaceae 976|Bacteroidetes S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR k59_819243_3 526218.Sterm_2744 4.27e-186 528.0 COG3007@1|root,COG3007@2|Bacteria,378D5@32066|Fusobacteria 32066|Fusobacteria I Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP) fabV - 1.3.1.44,1.3.1.9 ko:K00209 ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212 M00083 R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase k59_819243_4 411469.EUBHAL_01978 3.57e-88 269.0 COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia,25VB7@186806|Eubacteriaceae 186801|Clostridia E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_819243_5 926550.CLDAP_27210 1.43e-20 90.5 COG0133@1|root,COG0133@2|Bacteria,2G5Q3@200795|Chloroflexi 200795|Chloroflexi E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_132908_1 722419.PH505_ah00920 2.55e-30 123.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,2Q185@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Zn-dependent peptidases ptrA - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_459870_1 1125863.JAFN01000001_gene2185 7.1e-07 59.3 COG1404@1|root,COG4966@1|root,COG1404@2|Bacteria,COG4966@2|Bacteria 2|Bacteria NU pilus assembly protein PilW - - 3.4.21.62 ko:K01342,ko:K02672,ko:K20276 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko02035,ko02044,ko03110 - - - N_methyl,PPC,Peptidase_C2,PilW k59_656074_1 1322246.BN4_11385 1.79e-112 338.0 COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2M8E8@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_492456_1 1167006.UWK_01472 1.75e-79 246.0 COG0535@1|root,COG0535@2|Bacteria,1NEBZ@1224|Proteobacteria,42X7C@68525|delta/epsilon subdivisions,2WT60@28221|Deltaproteobacteria,2MMCC@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Radical SAM - - - - - - - - - - - - Radical_SAM k59_558064_1 666684.AfiDRAFT_3103 8.99e-10 56.2 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2U9JC@28211|Alphaproteobacteria,3JZE0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Sulphur oxidation protein SoxZ MA20_22825 - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_688567_1 1165841.SULAR_08107 6.56e-38 155.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind k59_986220_5 572544.Ilyop_0200 7.73e-27 103.0 2EBJS@1|root,335K7@2|Bacteria,37B3M@32066|Fusobacteria 32066|Fusobacteria - - atpI - - - - - - - - - - - ATP-synt_I k59_986220_6 572544.Ilyop_0201 1.77e-62 201.0 COG0356@1|root,COG0356@2|Bacteria,378C0@32066|Fusobacteria 32066|Fusobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_953455_2 1283300.ATXB01000001_gene2403 7.7e-27 108.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales 135618|Methylococcales S AAA-like domain - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 k59_430002_1 96561.Dole_2284 3.6e-146 423.0 COG0191@1|root,COG0191@2|Bacteria,1NMAK@1224|Proteobacteria,42NPW@68525|delta/epsilon subdivisions,2WIMN@28221|Deltaproteobacteria,2MHU7@213118|Desulfobacterales 28221|Deltaproteobacteria G aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_756956_1 986075.CathTA2_2248 2.29e-24 107.0 COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,4H9ZS@91061|Bacilli 91061|Bacilli O COG1331 Highly conserved protein containing a thioredoxin domain yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Glyco_hydro_9,Thioredox_DsbH k59_137652_12 631362.Thi970DRAFT_03553 3.6e-315 886.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_137652_13 754477.Q7C_714 6.95e-22 93.6 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the skp family skp GO:0001530,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0019867,GO:0022417,GO:0022607,GO:0030288,GO:0030312,GO:0030313,GO:0031647,GO:0031975,GO:0032978,GO:0033036,GO:0034613,GO:0042597,GO:0042802,GO:0043163,GO:0043165,GO:0043170,GO:0044085,GO:0044091,GO:0044238,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0050821,GO:0051082,GO:0051179,GO:0051205,GO:0051234,GO:0051604,GO:0051641,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0070727,GO:0071704,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0097367,GO:1901564 - ko:K06142 - - - - ko00000 - - - OmpH k59_137652_14 713586.KB900536_gene131 1.13e-65 218.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales 135613|Chromatiales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_137652_15 1249627.D779_1894 9.82e-65 202.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1WWV2@135613|Chromatiales 135613|Chromatiales I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_137652_16 243233.MCA2444 5.33e-92 279.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,1XECT@135618|Methylococcales 135618|Methylococcales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_137652_17 326442.PSHAa2017 3.32e-126 375.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,2PZUE@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478 LpxB k59_137652_18 305900.GV64_16255 1.84e-79 242.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,1XJ63@135619|Oceanospirillales 135619|Oceanospirillales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_137652_19 1049564.TevJSym_ba00030 0.0 1568.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1J4NP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III, alpha subunit dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_137652_20 1049564.TevJSym_ap00800 2.51e-185 520.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1J4RX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197 ACCA k59_137652_21 519989.ECTPHS_08568 3.35e-110 338.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales 135613|Chromatiales D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_137652_22 301.JNHE01000037_gene4292 1.95e-62 210.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1YDQM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria PT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Rhodanese,cNMP_binding k59_137652_24 674977.VMC_18580 1.7e-62 201.0 2BYAF@1|root,2ZWH8@2|Bacteria,1RBZ8@1224|Proteobacteria,1S3VD@1236|Gammaproteobacteria,1Y29R@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF3581) SO4011 - - - - - - - - - - - DUF3581 k59_137652_25 435908.IDSA_09120 1.36e-26 108.0 COG1246@1|root,COG1246@2|Bacteria,1QVUT@1224|Proteobacteria,1T2JM@1236|Gammaproteobacteria,2QFGE@267893|Idiomarinaceae 1236|Gammaproteobacteria E Putative thioesterase (yiiD_Cterm) - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,YiiD_C k59_137652_27 28229.ND2E_2067 6.83e-100 296.0 COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,1S0DD@1236|Gammaproteobacteria,2Q7MQ@267889|Colwelliaceae 1236|Gammaproteobacteria I MaoC like domain nodN - - - - - - - - - - - MaoC_dehydratas k59_137652_28 519989.ECTPHS_00230 2.31e-109 321.0 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0209 Ribonucleotide reductase, alpha subunit nrdJb - - - - - - - - - - - - k59_137652_29 697282.Mettu_3679 0.0 1161.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1XE1A@135618|Methylococcales 135618|Methylococcales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_137652_30 1049564.TevJSym_bm00110 1.19e-78 241.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,1J609@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain letA - - ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_137652_31 1049564.TevJSym_bm00120 7.46e-100 295.0 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria 1236|Gammaproteobacteria L uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_137652_32 1049564.TevJSym_bm00130 2.64e-263 740.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1J4GN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_137652_33 1049564.TevJSym_bm00140 4.59e-73 225.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1J656@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325 CDP-OH_P_transf k59_170467_1 1232437.KL661971_gene4909 4.66e-32 118.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_5,DDE_Tnp_1_4 k59_464602_1 929558.SMGD1_2736 6.01e-145 419.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2YM9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_104967_1 1341181.FLJC2902T_27220 5.42e-16 80.1 COG1216@1|root,COG1216@2|Bacteria,4PMPA@976|Bacteroidetes,1IKQF@117743|Flavobacteriia,2NWII@237|Flavobacterium 976|Bacteroidetes S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_366210_1 1537917.JU82_01665 1.21e-199 597.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2YMP9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_170472_1 1537917.JU82_05240 5.19e-106 321.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2YMB5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S abc transporter atp-binding protein yheS - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_1019732_1 572544.Ilyop_0937 9.38e-132 396.0 COG1523@1|root,COG1523@2|Bacteria,379NR@32066|Fusobacteria 32066|Fusobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.41,3.2.1.68 ko:K01200,ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_987005_1 1168034.FH5T_16770 1.59e-114 336.0 COG1091@1|root,COG1091@2|Bacteria,4NE3K@976|Bacteroidetes,2FN7H@200643|Bacteroidia 976|Bacteroidetes M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_888275_1 1249480.B649_09790 3.52e-81 251.0 COG0642@1|root,COG0642@2|Bacteria,1QZ1Z@1224|Proteobacteria,42SN7@68525|delta/epsilon subdivisions,2YPK7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c k59_4102_2 1123257.AUFV01000017_gene3745 1.65e-10 63.2 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1X5H6@135614|Xanthomonadales 135614|Xanthomonadales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_888282_1 1049564.TevJSym_ab01800 3.57e-51 174.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1J58A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0826 Collagenase and related proteases yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_888282_2 631362.Thi970DRAFT_00957 8.34e-19 84.3 COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,1S09K@1236|Gammaproteobacteria,1WX6Q@135613|Chromatiales 135613|Chromatiales S PFAM DMSO reductase anchor subunit (DmsC) - - - ko:K21309 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - DmsC k59_366220_1 1249480.B649_10345 3.16e-13 65.5 COG1433@1|root,COG1433@2|Bacteria,1P8Y4@1224|Proteobacteria,42VVM@68525|delta/epsilon subdivisions,2YQI1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - - k59_366220_2 387093.SUN_0114 1.96e-41 140.0 COG1734@1|root,COG1734@2|Bacteria,1N7D8@1224|Proteobacteria,42VPI@68525|delta/epsilon subdivisions,2YQRE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Prokaryotic dksA/traR C4-type zinc finger - - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_71895_1 572544.Ilyop_1899 3.21e-34 119.0 COG1188@1|root,COG1188@2|Bacteria,37ADV@32066|Fusobacteria 32066|Fusobacteria J S4 RNA-binding domain - - - - - - - - - - - - S4 k59_71895_2 572544.Ilyop_1898 1.62e-107 320.0 COG1947@1|root,COG1947@2|Bacteria,3795V@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N k59_71895_3 572544.Ilyop_1897 4.87e-49 157.0 COG2088@1|root,COG2088@2|Bacteria,37ASK@32066|Fusobacteria 32066|Fusobacteria D Could be involved in septation spoVG - - ko:K06412 - - - - ko00000 - - - SpoVG k59_627575_1 1168034.FH5T_06495 2.21e-96 288.0 COG0287@1|root,COG0287@2|Bacteria,4NEKF@976|Bacteroidetes,2FS5B@200643|Bacteroidia 976|Bacteroidetes E Prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_1019743_1 572544.Ilyop_1845 2.23e-50 180.0 COG1193@1|root,COG1193@2|Bacteria,378XS@32066|Fusobacteria 32066|Fusobacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_954056_1 1217718.ALOU01000007_gene1257 1.03e-110 342.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_692821_1 1168034.FH5T_14655 2.42e-19 84.3 COG2825@1|root,COG2825@2|Bacteria,4NQGG@976|Bacteroidetes,2FPTR@200643|Bacteroidia 976|Bacteroidetes M membrane - - - ko:K06142 - - - - ko00000 - - - OmpH k59_692821_2 1168034.FH5T_14650 6.77e-64 203.0 COG0506@1|root,COG0506@2|Bacteria,4NKZB@976|Bacteroidetes,2FW9Q@200643|Bacteroidia 976|Bacteroidetes E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh k59_267313_2 1223521.BBJX01000002_gene2865 8.77e-27 110.0 COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2VKFW@28216|Betaproteobacteria,4AH9U@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_692826_1 314256.OG2516_14775 1e-58 194.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria,2PCZY@252301|Oceanicola 28211|Alphaproteobacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_823678_2 387631.Asulf_02020 2.4e-27 103.0 COG1917@1|root,arCOG02992@2157|Archaea,2XZHW@28890|Euryarchaeota 28890|Euryarchaeota G PFAM Cupin - - - - - - - - - - - - Cupin_2 k59_823678_3 1121859.KB890754_gene880 8.5e-61 194.0 COG3448@1|root,COG3448@2|Bacteria,4NMHI@976|Bacteroidetes,47P6M@768503|Cytophagia 976|Bacteroidetes T HPP family - - - - - - - - - - - - HPP k59_987038_1 1049564.TevJSym_ac00730 4.45e-57 191.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,1RM9W@1236|Gammaproteobacteria,1J55H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_987038_2 1049564.TevJSym_ac00740 2.56e-47 158.0 COG1317@1|root,COG1317@2|Bacteria,1NBN3@1224|Proteobacteria,1SWWK@1236|Gammaproteobacteria,1J6X3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar biosynthesis type III secretory pathway protein - - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH k59_725323_1 931276.Cspa_c51590 2.62e-114 336.0 28H6R@1|root,2Z7J3@2|Bacteria,1TQ2I@1239|Firmicutes,247QF@186801|Clostridia,36EPD@31979|Clostridiaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - k59_333883_1 335543.Sfum_1166 2.82e-103 308.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MQWC@213462|Syntrophobacterales 28221|Deltaproteobacteria C oxidoreductase, alpha subunit korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_757723_1 572480.Arnit_2536 2.2e-57 200.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YM9E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL,Patched k59_137708_1 313606.M23134_06951 3.25e-73 232.0 COG0451@1|root,COG0451@2|Bacteria,4NJ2M@976|Bacteroidetes,47XKC@768503|Cytophagia 976|Bacteroidetes M NmrA-like family - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_823680_1 335543.Sfum_1724 6.58e-170 487.0 COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJ17@28221|Deltaproteobacteria,2MRAB@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S double cluster binding domain - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4,Fer4_16,Glu_synthase k59_856392_1 1131269.AQVV01000050_gene421 1.56e-50 175.0 COG0305@1|root,COG0305@2|Bacteria 2|Bacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_922161_2 643562.Daes_0674 4.68e-75 230.0 COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,42MVA@68525|delta/epsilon subdivisions,2WKBW@28221|Deltaproteobacteria,2M89C@213115|Desulfovibrionales 28221|Deltaproteobacteria S beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k59_366248_1 237609.PSAKL28_42990 8.26e-24 97.8 COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0307 family yjgA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_71927_2 572544.Ilyop_1083 1.65e-47 161.0 28MXK@1|root,2ZB4K@2|Bacteria,378AI@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_627609_1 522772.Dacet_2603 2.61e-91 285.0 COG2252@1|root,COG2252@2|Bacteria,2GF9Y@200930|Deferribacteres 200930|Deferribacteres S Permease family - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k59_300080_1 749222.Nitsa_0748 2.01e-46 154.0 COG0822@1|root,COG0822@2|Bacteria,1Q30Q@1224|Proteobacteria,42WJQ@68525|delta/epsilon subdivisions,2YQE5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM NifU-like N terminal domain - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_300080_2 387093.SUN_1078 7.1e-15 73.2 COG1633@1|root,COG1633@2|Bacteria,1Q0JN@1224|Proteobacteria,42S76@68525|delta/epsilon subdivisions,2YP4Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - - - - - - - - - - - k59_757742_1 351348.Maqu_2345 4.66e-90 281.0 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,1RRA5@1236|Gammaproteobacteria,46AE0@72275|Alteromonadaceae 1236|Gammaproteobacteria EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_71939_1 626887.J057_07711 8.03e-38 139.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RP71@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1062 Zn-dependent alcohol dehydrogenases, class III - - 1.1.1.90 ko:K00055 ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220 M00537,M00538 R01763,R02611,R04304,R05282,R05347,R05348 RC00087,RC00116 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_235282_1 1168034.FH5T_14380 3.45e-14 70.5 COG0605@1|root,COG0605@2|Bacteria,4P18A@976|Bacteroidetes,2FW9K@200643|Bacteroidia 976|Bacteroidetes P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_235282_2 1168034.FH5T_14375 6.89e-23 97.8 COG3307@1|root,COG3307@2|Bacteria 2|Bacteria M -O-antigen - - - ko:K16705 - - - - ko00000 - - - Wzy_C k59_692842_1 1185876.BN8_02842 2.98e-72 238.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,4NGF6@976|Bacteroidetes,47NEG@768503|Cytophagia 976|Bacteroidetes P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefC - - ko:K03455,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_692842_2 504832.OCAR_4913 4.03e-37 135.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,3JTI5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P cation efflux czcD - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_333913_1 177437.HRM2_04990 9.91e-95 285.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MII7@213118|Desulfobacterales 28221|Deltaproteobacteria NU PFAM type II secretion system protein E - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_4131_1 1348635.BBJY01000010_gene1391 2.08e-98 287.0 COG0454@1|root,COG0456@2|Bacteria,1QTY5@1224|Proteobacteria,1S6M9@1236|Gammaproteobacteria,1Y36G@135623|Vibrionales 135623|Vibrionales K Acetyltransferase (GNAT) domain - - - ko:K03825 - - - - ko00000,ko01000 - - - Acetyltransf_1 k59_137734_1 1121904.ARBP01000017_gene5109 7.04e-115 344.0 COG5476@1|root,COG5476@2|Bacteria,4NG23@976|Bacteroidetes,47NWD@768503|Cytophagia 976|Bacteroidetes S MlrC C-terminus - - - - - - - - - - - - DUF1485,MlrC_C k59_856408_1 595460.RRSWK_00056 2.53e-18 84.7 COG0494@1|root,COG0494@2|Bacteria,2J0TH@203682|Planctomycetes 203682|Planctomycetes L NUDIX domain - - - - - - - - - - - - NUDIX k59_856408_2 1232683.ADIMK_3982 1.19e-56 184.0 COG0406@1|root,COG0406@2|Bacteria,1RA6X@1224|Proteobacteria,1S7GE@1236|Gammaproteobacteria,46AT3@72275|Alteromonadaceae 1236|Gammaproteobacteria G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_954092_1 317025.Tcr_0558 8.55e-40 138.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,4610X@72273|Thiotrichales 72273|Thiotrichales K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_888340_1 749222.Nitsa_0619 2.64e-65 216.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2YNN7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1019788_1 1249480.B649_01465 4e-12 66.6 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2YNJC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1019788_2 929558.SMGD1_0803 5.65e-56 186.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2YMBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1055 Na H antiporter NhaD and related arsenite - - - - - - - - - - - - CitMHS k59_497079_1 110319.CF8_2886 7.73e-13 69.3 COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,4DNV9@85009|Propionibacteriales 201174|Actinobacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0008150,GO:0040007 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2977c AIRS,AIRS_C k59_267701_2 641107.CDLVIII_1724 5.61e-37 132.0 COG3279@1|root,COG3279@2|Bacteria,1V14X@1239|Firmicutes,24BG9@186801|Clostridia,36E97@31979|Clostridiaceae 186801|Clostridia KT response regulator ypdB - - ko:K02477,ko:K07705 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_271920_1 395494.Galf_0305 1.58e-87 264.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,44VCV@713636|Nitrosomonadales 28216|Betaproteobacteria E ABC transporter livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_208407_1 179408.Osc7112_1147 5.63e-61 201.0 COG3335@1|root,COG3335@2|Bacteria,1G4FA@1117|Cyanobacteria,1HBRR@1150|Oscillatoriales 1117|Cyanobacteria L K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_240365_1 1049564.TevJSym_ap00540 1.68e-15 72.8 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_240365_2 765912.Thimo_0594 7.65e-73 226.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1WXHS@135613|Chromatiales 135613|Chromatiales C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_959346_1 1168034.FH5T_14745 9.99e-21 90.5 COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,2FMX8@200643|Bacteroidia 976|Bacteroidetes S ABC transporter, ATP-binding protein yfmR - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_959346_2 1168034.FH5T_14750 2.15e-47 164.0 COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes 976|Bacteroidetes V Beta-lactamase class C and other penicillin binding - - 3.5.2.6 ko:K01467 ko01501,ko02020,map01501,map02020 M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000 - - - Beta-lactamase k59_793651_2 640081.Dsui_2760 5.88e-15 70.5 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,2KX94@206389|Rhodocyclales 206389|Rhodocyclales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex - - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_793651_3 546269.HMPREF0389_00822 2.81e-31 114.0 COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,25RFY@186804|Peptostreptococcaceae 186801|Clostridia J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_793651_4 906968.Trebr_2272 1.78e-30 113.0 COG0100@1|root,COG0100@2|Bacteria,2J7BP@203691|Spirochaetes 203691|Spirochaetes J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_793651_5 1158318.ATXC01000001_gene1248 4.92e-33 124.0 COG0522@1|root,COG0522@2|Bacteria,2G402@200783|Aquificae 200783|Aquificae J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_175888_1 700598.Niako_6619 1.03e-17 81.6 COG0575@1|root,COG0575@2|Bacteria,4PPXI@976|Bacteroidetes,1J13D@117747|Sphingobacteriia 976|Bacteroidetes I Cytidylyltransferase family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_175888_2 1168034.FH5T_09645 9.46e-132 379.0 COG1183@1|root,COG1183@2|Bacteria,4NNUZ@976|Bacteroidetes,2FPNM@200643|Bacteroidia 976|Bacteroidetes I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_271931_1 580332.Slit_2219 9.23e-59 197.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VH4Z@28216|Betaproteobacteria,44V1P@713636|Nitrosomonadales 28216|Betaproteobacteria E PFAM aminotransferase class I and II alaA - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_403637_1 292564.Cyagr_2807 2.88e-37 140.0 COG0486@1|root,COG0486@2|Bacteria,1G189@1117|Cyanobacteria,22S4Q@167375|Cyanobium 1117|Cyanobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_698100_1 1208323.B30_15276 1.1e-92 275.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2TVD3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_240375_2 643867.Ftrac_2073 2.88e-77 243.0 COG1327@1|root,COG1327@2|Bacteria,4NHXI@976|Bacteroidetes,47P1Y@768503|Cytophagia 976|Bacteroidetes K PFAM ATP cone domain - - - - - - - - - - - - ATP-cone,Mrr_cat k59_304921_1 72664.XP_006405523.1 7.17e-259 709.0 28IP8@1|root,2QR09@2759|Eukaryota,37PUB@33090|Viridiplantae,3GEYD@35493|Streptophyta,3HX10@3699|Brassicales 35493|Streptophyta C Photosystem II (PSII) is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1 D2 (PsbA PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors psbA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0010287,GO:0016020,GO:0016168,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0046906,GO:0048037,GO:0055035,GO:0097159,GO:1901363 1.10.3.9 ko:K02703,ko:K20000 ko00195,ko01100,map00195,map01100 M00161 - - ko00000,ko00001,ko00002,ko00194,ko01000,ko03016 - - - Photo_RC k59_469447_1 768671.ThimaDRAFT_4579 2.11e-103 315.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WXJT@135613|Chromatiales 135613|Chromatiales F Belongs to the 5'-nucleotidase family - - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_503145_1 1123503.KB908056_gene1698 2.43e-46 167.0 COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria,2TXK8@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Sodium:solute symporter family - - - - - - - - - - - - SSF k59_959376_1 1121405.dsmv_3174 2.06e-56 196.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2MJ5W@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_208447_1 1120965.AUBV01000009_gene2976 1.46e-29 121.0 COG1075@1|root,COG4995@1|root,COG1075@2|Bacteria,COG4995@2|Bacteria,4NIP9@976|Bacteroidetes,47QPU@768503|Cytophagia 976|Bacteroidetes I Lecithin:cholesterol acyltransferase - - - - - - - - - - - - CHAT,LCAT k59_633264_1 1499967.BAYZ01000095_gene4215 1.17e-25 99.0 COG3370@1|root,COG3370@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - DrsE k59_633264_2 756499.Desde_0465 2.95e-42 159.0 COG2199@1|root,COG4564@1|root,COG2199@2|Bacteria,COG4564@2|Bacteria,1TPJW@1239|Firmicutes,248VA@186801|Clostridia 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_2,sCache_2 k59_633264_3 526218.Sterm_1929 1.49e-89 273.0 COG1533@1|root,COG1533@2|Bacteria,3788N@32066|Fusobacteria 32066|Fusobacteria L Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - k59_240382_1 1168034.FH5T_08525 1.24e-107 318.0 COG1609@1|root,COG1609@2|Bacteria,4NDW6@976|Bacteroidetes,2FM9W@200643|Bacteroidia 976|Bacteroidetes K Transcriptional regulator, LacI family cytR - - ko:K02529,ko:K05499 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k59_828865_1 1200792.AKYF01000017_gene5567 1.22e-72 248.0 COG0236@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksJ - - ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_763051_1 1136163.M565_ctg1P1803 7.7e-10 60.8 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1XTR8@135623|Vibrionales 135623|Vibrionales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - Methyltransf_31 k59_763051_2 1408445.JHXP01000011_gene862 3.65e-65 209.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1JCHB@118969|Legionellales 118969|Legionellales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_435854_2 1229204.AMYY01000006_gene1096 1.69e-09 62.4 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2TS0E@28211|Alphaproteobacteria,4BPWQ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_304936_1 309801.trd_1711 2.31e-06 53.5 COG0317@1|root,COG0317@2|Bacteria,2G67Y@200795|Chloroflexi,27XXG@189775|Thermomicrobia 189775|Thermomicrobia KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_240385_1 1123277.KB893176_gene3684 8.19e-05 50.4 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,47JJ5@768503|Cytophagia 976|Bacteroidetes S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_793672_1 519989.ECTPHS_03162 1.53e-40 150.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales 135613|Chromatiales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_435857_1 765912.Thimo_1257 1.04e-42 146.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1WY2S@135613|Chromatiales 135613|Chromatiales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate tsaC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_1024613_2 743719.PaelaDRAFT_2306 5.78e-16 78.6 COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,4HFUM@91061|Bacilli,26QMM@186822|Paenibacillaceae 91061|Bacilli S Belongs to the multicopper oxidase YfiH RL5 family ylmD GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_175920_2 1168034.FH5T_12110 3.61e-113 333.0 COG0324@1|root,COG0324@2|Bacteria,4NEAE@976|Bacteroidetes,2FNES@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_1024614_1 489825.LYNGBM3L_74450 3.46e-23 103.0 COG0604@1|root,COG3321@1|root,COG0604@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria 1117|Cyanobacteria Q Beta-ketoacyl synthase, N-terminal domain - - - - - - - - - - - - ADH_N,ADH_zinc_N_2,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Sulfotransfer_3,ketoacyl-synt k59_600622_1 589873.EP13_05960 8.33e-248 711.0 COG4928@1|root,COG4928@2|Bacteria,1PJ9W@1224|Proteobacteria,1S0GQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S p-loop domain protein - - - - - - - - - - - - KAP_NTPase k59_793674_1 1168034.FH5T_13735 1.27e-118 359.0 COG4206@1|root,COG4206@2|Bacteria,4NED9@976|Bacteroidetes,2FMA6@200643|Bacteroidia 976|Bacteroidetes H COG4206 Outer membrane cobalamin receptor protein btuB - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_271962_1 1415780.JPOG01000001_gene2740 9.81e-16 78.2 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1XCEY@135614|Xanthomonadales 135614|Xanthomonadales C Molydopterin dinucleotide binding domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_271962_3 472759.Nhal_1621 5.28e-31 115.0 COG3381@1|root,COG3381@2|Bacteria,1PYCM@1224|Proteobacteria,1THFE@1236|Gammaproteobacteria,1X123@135613|Chromatiales 135613|Chromatiales S PFAM cytoplasmic chaperone TorD family protein - - - - - - - - - - - - Nitrate_red_del k59_143666_1 387093.SUN_1086 1.27e-61 202.0 COG4865@1|root,COG4865@2|Bacteria,1PCBW@1224|Proteobacteria,42PTY@68525|delta/epsilon subdivisions,2YMYF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Methylaspartate mutase - - 5.4.99.1 ko:K19268 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R00262 RC01221 ko00000,ko00001,ko00002,ko01000 - - - Met_asp_mut_E k59_143666_2 1565314.OA34_04130 8.47e-16 72.4 COG2185@1|root,COG2185@2|Bacteria,1RB2M@1224|Proteobacteria,42RER@68525|delta/epsilon subdivisions,2YP7X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Methylaspartate mutase mamA - 5.4.99.1 ko:K01846 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R00262 RC01221 ko00000,ko00001,ko00002,ko01000 - - - B12-binding k59_110240_1 709032.Sulku_2557 5.81e-70 233.0 COG3550@1|root,COG3550@2|Bacteria,1RHBA@1224|Proteobacteria,42MXT@68525|delta/epsilon subdivisions,2YMIQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_633283_1 1249627.D779_0311 1.15e-101 301.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1WW98@135613|Chromatiales 135613|Chromatiales Q PFAM ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_175928_1 1249480.B649_02885 2.5e-165 477.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2YMUQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_77910_1 572477.Alvin_1230 2.25e-116 345.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1WW9J@135613|Chromatiales 135613|Chromatiales F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_601324_1 1121013.P873_00650 9.79e-71 245.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales 135614|Xanthomonadales E glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_372245_1 981327.F925_02631 2.74e-07 51.2 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,3NJHP@468|Moraxellaceae 1236|Gammaproteobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_372245_2 1187848.AJYQ01000032_gene2271 1.86e-38 136.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1XTPC@135623|Vibrionales 135623|Vibrionales J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_993507_1 2340.JV46_07080 1.43e-263 731.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1J4ZC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_698778_1 1168034.FH5T_11140 2.03e-113 335.0 COG0477@1|root,COG2814@2|Bacteria,4NMJE@976|Bacteroidetes 976|Bacteroidetes EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_209135_1 1121012.AUKX01000033_gene600 2.64e-21 92.4 COG4409@1|root,COG4409@2|Bacteria,4NFNK@976|Bacteroidetes,1HYN6@117743|Flavobacteriia,23GU9@178469|Arenibacter 976|Bacteroidetes G BNR repeat-like domain - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - BNR_2 k59_209135_2 1168034.FH5T_05995 6.33e-30 115.0 COG2957@1|root,COG2957@2|Bacteria,4NGF8@976|Bacteroidetes,2FMQH@200643|Bacteroidia 976|Bacteroidetes E Belongs to the agmatine deiminase family aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_536261_1 1123279.ATUS01000001_gene2547 7.04e-22 99.4 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,1J66B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins tonB3 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1025056_1 929558.SMGD1_0894 2.77e-81 268.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2YMMS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_241004_1 367737.Abu_0335 1.34e-10 59.7 COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2YPGS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp k59_241004_2 909663.KI867150_gene179 2.49e-09 63.5 COG0810@1|root,COG0810@2|Bacteria,1N94H@1224|Proteobacteria,42V43@68525|delta/epsilon subdivisions,2WRRA@28221|Deltaproteobacteria,2MRUT@213462|Syntrophobacterales 28221|Deltaproteobacteria M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_241004_3 182217.HCW_00875 1.17e-21 90.5 COG0848@1|root,COG0848@2|Bacteria,1N9DN@1224|Proteobacteria,42V0H@68525|delta/epsilon subdivisions,2YQ7R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U biopolymer transport protein exbD2 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_241004_4 326298.Suden_1002 6.1e-53 171.0 COG0811@1|root,COG0811@2|Bacteria,1RK2P@1224|Proteobacteria,42TPV@68525|delta/epsilon subdivisions,2YTR7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U MotA/TolQ/ExbB proton channel family exbB1 - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_928380_1 1239962.C943_00031 5.03e-76 255.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,4NETY@976|Bacteroidetes,47NAM@768503|Cytophagia 976|Bacteroidetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_601342_1 1537917.JU82_10615 3.25e-135 397.0 COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,42N2D@68525|delta/epsilon subdivisions,2YNAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_763793_1 224308.BSU14730 0.000188 47.8 COG1595@1|root,COG1595@2|Bacteria,1V1S3@1239|Firmicutes,4HG2H@91061|Bacilli,1ZGKM@1386|Bacillus 91061|Bacilli K Belongs to the sigma-70 factor family. ECF subfamily ylaC - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_372261_1 1026882.MAMP_03110 1.81e-34 127.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,4606P@72273|Thiotrichales 72273|Thiotrichales F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_372261_2 582744.Msip34_0462 8.45e-18 82.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,2KKDP@206350|Nitrosomonadales 206350|Nitrosomonadales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_794101_1 391587.KAOT1_10461 1.18e-77 242.0 28JVI@1|root,2Z9KH@2|Bacteria,4NI2G@976|Bacteroidetes,1I0EK@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_568522_1 500633.CLOHIR_01656 1.83e-15 83.6 COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia 186801|Clostridia M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins prsA - 5.2.1.8 ko:K03769,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_568522_2 572544.Ilyop_1760 1.05e-291 799.0 COG0148@1|root,COG0148@2|Bacteria,378QW@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_436523_1 96561.Dole_0201 1.07e-30 125.0 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - ko:K15125,ko:K19231 ko05133,map05133 - - - ko00000,ko00001,ko00536,ko02000 1.B.12 - - DUF637,ESPR,Fil_haemagg_2,Haemagg_act,PATR,PT-VENN k59_503922_1 1121403.AUCV01000045_gene1130 3.05e-48 174.0 COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CHE@68525|delta/epsilon subdivisions,2X7SI@28221|Deltaproteobacteria 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_209158_2 768671.ThimaDRAFT_3347 3.74e-30 118.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales 135613|Chromatiales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_77942_1 869213.JCM21142_93472 5.32e-93 277.0 COG5012@1|root,COG5012@2|Bacteria,4P0JY@976|Bacteroidetes 976|Bacteroidetes S B12 binding domain - - - - - - - - - - - - B12-binding,B12-binding_2 k59_895027_1 856793.MICA_2375 5.44e-24 107.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2TS9S@28211|Alphaproteobacteria,4BQFG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_763806_1 1165841.SULAR_07335 1.34e-95 288.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2YN0V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Potassium channel protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_763812_1 387093.SUN_1150 9.19e-117 352.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2YN92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_568533_1 933262.AXAM01000044_gene1408 3.82e-105 319.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2MKFC@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_1025092_1 1381123.AYOD01000002_gene554 2.12e-14 77.0 COG3768@1|root,COG3768@2|Bacteria,1MU8S@1224|Proteobacteria,2TU53@28211|Alphaproteobacteria,43I9F@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S UPF0283 membrane protein MA20_04555 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08990 - - - - ko00000 - - - DUF697 k59_77954_1 580332.Slit_1243 5.67e-104 310.0 28IVT@1|root,2Z8U5@2|Bacteria,1R7G9@1224|Proteobacteria,2W17G@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_573563_1 582402.Hbal_2820 5.18e-17 86.3 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,43X0T@69657|Hyphomonadaceae 28211|Alphaproteobacteria H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_277338_1 420662.Mpe_B0541 1.01e-119 357.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,1KK96@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Methylmalonyl-CoA mutase icmF - 5.4.99.2,5.4.99.63,5.4.99.64 ko:K01847,ko:K01848,ko:K14447,ko:K20906 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R09292 RC00395,RC02835 ko00000,ko00001,ko00002,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_933289_1 56780.SYN_00295 6.2e-104 337.0 COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Alpha amylase catalytic - - - - - - - - - - - - Alpha-amylase,GDE_C,GDE_N k59_866771_1 443144.GM21_2024 1.03e-73 242.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_866771_2 215803.DB30_2997 2.77e-33 122.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WMVB@28221|Deltaproteobacteria,2YUCK@29|Myxococcales 28221|Deltaproteobacteria P Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_409486_1 1123269.NX02_21130 2.83e-11 70.1 2DN0U@1|root,32UTB@2|Bacteria,1MZ2J@1224|Proteobacteria,2UHAI@28211|Alphaproteobacteria,2K24S@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_541489_1 1049564.TevJSym_ap00050 4.78e-111 345.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_277348_1 572544.Ilyop_0319 1.14e-103 314.0 COG3333@1|root,COG3333@2|Bacteria,3789P@32066|Fusobacteria 32066|Fusobacteria S Tripartite tricarboxylate transporter TctA family - - - - - - - - - - - - TctA k59_12241_1 452637.Oter_0338 7.29e-74 232.0 COG0673@1|root,COG0673@2|Bacteria,46TZD@74201|Verrucomicrobia,3K7GN@414999|Opitutae 2|Bacteria C PFAM oxidoreductase domain protein socC - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_998637_2 321955.AAGP01000005_gene66 6.4e-24 98.2 COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4F9WU@85019|Brevibacteriaceae 201174|Actinobacteria J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc k59_933299_1 331678.Cphamn1_0510 1.2e-137 394.0 COG0428@1|root,COG0428@2|Bacteria,1FEX5@1090|Chlorobi 1090|Chlorobi P PFAM zinc iron permease - - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - Zip k59_541494_1 387093.SUN_0639 8.17e-124 359.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2YMCC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_541861_82 2340.JV46_13550 2.02e-34 119.0 COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,1S8V9@1236|Gammaproteobacteria,1J6YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane - - - - - - - - - - - - DUF4212 k59_541861_83 2340.JV46_13540 6.11e-84 264.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1J589@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_346434_1 99598.Cal7507_3494 2.45e-08 55.1 COG0102@1|root,COG0102@2|Bacteria,1G512@1117|Cyanobacteria,1HJF2@1161|Nostocales 1117|Cyanobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_346434_2 1384054.N790_06705 2.53e-48 166.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1X31C@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_215125_1 981223.AIED01000006_gene3494 1.9e-33 127.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,3NIRA@468|Moraxellaceae 1236|Gammaproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iPC815.YPO3849 Porphobil_deam,Porphobil_deamC k59_215125_2 686340.Metal_2980 4.57e-06 47.8 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1XEZI@135618|Methylococcales 135618|Methylococcales H Uroporphyrinogen-III synthase HemD - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_509916_2 84531.JMTZ01000012_gene2935 3.52e-07 57.8 COG1404@1|root,COG1404@2|Bacteria,1REF1@1224|Proteobacteria 1224|Proteobacteria O PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - - - - - - - - - - CARDB,Peptidase_M6,Peptidase_S8 k59_574177_1 1121405.dsmv_3072 9e-81 259.0 COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2MHN0@213118|Desulfobacterales 28221|Deltaproteobacteria G Phosphofructokinase pfp - 2.7.1.11,2.7.1.90 ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_769780_2 1163617.SCD_n02256 6.81e-89 269.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria 28216|Betaproteobacteria Q Methyltransferase type 11 - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_116344_1 1487953.JMKF01000006_gene5813 8.56e-82 273.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria,1H9JF@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Conserved region in glutamate synthase gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.7.1 ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 - R00021,R10086 RC00006,RC00010 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_48913_1 1049564.TevJSym_as00150 3.3e-60 207.0 COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1JAB5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acid phosphatase homologues lssY - - ko:K03975 - - - - ko00000 - - - LssY_C,PAP2,SNARE_assoc k59_769790_1 42565.FP66_12900 1.2e-24 106.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1XIFW@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase III subunit delta holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_475316_1 380358.XALC_0966 2.23e-16 79.7 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria,1X5MS@135614|Xanthomonadales 135614|Xanthomonadales Q Oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_475316_2 247634.GPB2148_1633 1.29e-51 176.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1233 Phytoene dehydrogenase and related proteins - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_311479_1 1226325.HMPREF1548_04319 2.45e-89 275.0 COG0583@1|root,COG0583@2|Bacteria,1TP77@1239|Firmicutes,248CX@186801|Clostridia,36F5V@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_1030696_1 714943.Mucpa_6747 3.37e-50 166.0 COG3254@1|root,COG3254@2|Bacteria,4NPCW@976|Bacteroidetes,1IXD4@117747|Sphingobacteriia 976|Bacteroidetes M Pfam:DUF718 - - - - - - - - - - - - rhaM k59_1030696_2 1233951.IO90_08980 4.77e-05 47.8 COG4447@1|root,COG4447@2|Bacteria,4NJBH@976|Bacteroidetes,1I0PK@117743|Flavobacteriia 976|Bacteroidetes S Leucine-rich repeat (LRR) protein - - - - - - - - - - - - Sortilin-Vps10 k59_509944_1 572544.Ilyop_0818 4.97e-87 268.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups gtf1 GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758 2.4.1.52 ko:K00712 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_A_1,Glycos_transf_1 k59_607240_1 908612.HMPREF9720_1245 7.32e-25 100.0 COG1561@1|root,COG1561@2|Bacteria,4NEU4@976|Bacteroidetes,2FPBF@200643|Bacteroidia,22V1R@171550|Rikenellaceae 976|Bacteroidetes S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N k59_607240_2 883096.HMPREF9699_01744 1.56e-27 104.0 2CCSR@1|root,32RWC@2|Bacteria,4NSDM@976|Bacteroidetes,1I40W@117743|Flavobacteriia 976|Bacteroidetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_607241_1 1206733.BAGC01000022_gene4642 1.31e-10 65.1 COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4FVV0@85025|Nocardiaceae 201174|Actinobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_835224_1 246194.CHY_0957 3.43e-15 73.9 COG0496@1|root,COG0496@2|Bacteria,1TS2T@1239|Firmicutes,24BI5@186801|Clostridia,42G1B@68295|Thermoanaerobacterales 186801|Clostridia F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_377773_1 797210.Halxa_3778 0.000752 47.8 COG5520@1|root,arCOG09138@2157|Archaea,2XYQW@28890|Euryarchaeota,23X9W@183963|Halobacteria 183963|Halobacteria G Ricin-type beta-trefoil - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - Glyco_hydro_11,RicinB_lectin_2 k59_933868_1 1168034.FH5T_05690 5.22e-227 664.0 COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,2FMIV@200643|Bacteroidia 976|Bacteroidetes S Peptidase family C25 porU - - - - - - - - - - - Peptidase_C25 k59_769808_1 314287.GB2207_08816 2.06e-14 73.6 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1J4GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0569 K transport systems, NAD-binding component trkA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655 - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iE2348C_1286.E2348C_3552 TrkA_C,TrkA_N k59_769808_2 349521.HCH_00025 9.82e-23 99.8 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XHSI@135619|Oceanospirillales 135619|Oceanospirillales P Trk system potassium uptake protein trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_867416_1 1163408.UU9_16111 1.23e-94 302.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1X3DK@135614|Xanthomonadales 135614|Xanthomonadales J due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_116379_1 713587.THITH_07390 1.1e-59 209.0 COG0457@1|root,COG0457@2|Bacteria,1QZTW@1224|Proteobacteria,1T54Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554 k59_799236_1 1121459.AQXE01000005_gene1556 5.43e-32 124.0 COG0574@1|root,COG3651@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3651@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42NYJ@68525|delta/epsilon subdivisions,2WKWS@28221|Deltaproteobacteria,2M9PD@213115|Desulfovibrionales 28221|Deltaproteobacteria GT Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_799236_4 635013.TherJR_2008 2.2e-15 72.4 2ERYM@1|root,33JHS@2|Bacteria,1VMJJ@1239|Firmicutes,2530R@186801|Clostridia 186801|Clostridia S MTH538 TIR-like domain (DUF1863) - - - - - - - - - - - - DUF1863 k59_1030727_1 1049564.TevJSym_aa01890 1.66e-110 332.0 COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_999342_1 748658.KB907317_gene282 2.08e-99 319.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1030728_1 768710.DesyoDRAFT_5196 2.98e-40 147.0 COG5301@1|root,COG5301@2|Bacteria,1UZU2@1239|Firmicutes,24EJ3@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF2793) - - - - - - - - - - - - DUF2793 k59_1030728_3 1121406.JAEX01000044_gene2568 1.09e-05 52.4 COG4385@1|root,COG4385@2|Bacteria,1NZST@1224|Proteobacteria,42X5S@68525|delta/epsilon subdivisions,2WVXA@28221|Deltaproteobacteria,2MCYG@213115|Desulfovibrionales 28221|Deltaproteobacteria S TIGRFAM Phage tail protein I - - - - - - - - - - - - Tail_P2_I k59_475347_1 479433.Caci_2118 1.23e-84 268.0 COG1960@1|root,COG1960@2|Bacteria,2GQPU@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase fadE4 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_182649_1 765910.MARPU_11065 7.14e-08 53.1 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWG5@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_182649_2 765912.Thimo_3126 3.95e-133 389.0 COG0842@1|root,COG0842@2|Bacteria,1QTBE@1224|Proteobacteria,1RNG9@1236|Gammaproteobacteria,1WXPD@135613|Chromatiales 135613|Chromatiales U Transport permease protein - - - - - - - - - - - - ABC2_membrane k59_867442_1 1232683.ADIMK_0794 1.13e-64 214.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,464F2@72275|Alteromonadaceae 1236|Gammaproteobacteria J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_215173_1 765911.Thivi_3675 9.81e-109 328.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_966089_1 631362.Thi970DRAFT_01411 2.96e-100 316.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales 135613|Chromatiales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_933894_1 572480.Arnit_1509 3.96e-09 64.7 COG2304@1|root,COG2911@1|root,COG2931@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,42TVF@68525|delta/epsilon subdivisions 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,VWA_2 k59_442196_1 443254.Marpi_1265 8.27e-37 138.0 COG1309@1|root,COG1309@2|Bacteria,2GD9U@200918|Thermotogae 200918|Thermotogae K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_607273_1 1168034.FH5T_20535 7.03e-100 297.0 COG0280@1|root,COG0280@2|Bacteria,4NJPR@976|Bacteroidetes,2FN8U@200643|Bacteroidia 976|Bacteroidetes C phosphate butyryltransferase ptb - 2.3.1.19 ko:K00634 ko00650,ko01100,map00650,map01100 - R01174 RC00004,RC02816 ko00000,ko00001,ko01000 - - - PTA_PTB k59_12937_1 768671.ThimaDRAFT_1053 2.41e-89 267.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,1WW9E@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_639830_1 443144.GM21_0435 1.72e-52 187.0 COG1361@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria 28221|Deltaproteobacteria M TIGRFAM conserved repeat domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_215187_1 1031711.RSPO_c02122 3.52e-66 217.0 COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2VKUT@28216|Betaproteobacteria,1K24H@119060|Burkholderiaceae 28216|Betaproteobacteria G abc transporter - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_215187_2 1121288.AULL01000020_gene2555 4.81e-15 75.9 COG1525@1|root,COG1525@2|Bacteria,4NT0S@976|Bacteroidetes,1I47N@117743|Flavobacteriia,3ZRXV@59732|Chryseobacterium 976|Bacteroidetes L nuclease lpxP - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase k59_215187_3 1035196.HMPREF9998_01874 6.15e-67 217.0 COG0212@1|root,COG1636@1|root,COG0212@2|Bacteria,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,25RIZ@186804|Peptostreptococcaceae 186801|Clostridia C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queH - 1.17.99.6 ko:K09765 - - - - ko00000,ko01000,ko03016 - - - DUF208 k59_215187_4 580340.Tlie_0154 1.02e-74 238.0 COG0803@1|root,COG0803@2|Bacteria,3TB3X@508458|Synergistetes 508458|Synergistetes P PFAM periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_541958_1 555778.Hneap_0406 1.86e-57 195.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales 135613|Chromatiales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_278021_1 573569.F7308_1614 1.2e-10 60.8 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,46062@72273|Thiotrichales 72273|Thiotrichales HJM Carbamoyl-phosphate synthase L chain, ATP binding domain cphA - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK k59_278021_2 1121015.N789_00870 5.43e-66 209.0 COG4242@1|root,COG4242@2|Bacteria,1PR9J@1224|Proteobacteria,1RVJH@1236|Gammaproteobacteria 1236|Gammaproteobacteria PQ Belongs to the peptidase S51 family - - 3.4.15.6 ko:K13282 - - R09722 RC00064,RC00141 ko00000,ko01000,ko01002 - - - Peptidase_S51 k59_311550_1 1121123.AUAO01000001_gene1018 2.19e-31 120.0 COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,2U45K@28211|Alphaproteobacteria,2KGD8@204458|Caulobacterales 204458|Caulobacterales S methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_311559_1 457425.XNR_0695 1.5e-55 194.0 COG2268@1|root,COG2268@2|Bacteria,2GKB2@201174|Actinobacteria 201174|Actinobacteria S Band 7 protein - - - - - - - - - - - - Band_7 k59_510019_1 1279017.AQYJ01000025_gene529 2.03e-79 262.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,46425@72275|Alteromonadaceae 1236|Gammaproteobacteria V Efflux pump acrB - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_150097_1 452637.Oter_3716 3.38e-40 152.0 COG3408@1|root,COG3408@2|Bacteria,46TIY@74201|Verrucomicrobia,3K805@414999|Opitutae 414999|Opitutae G Bacterial alpha-L-rhamnosidase C-terminal domain - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C k59_900719_1 1408422.JHYF01000002_gene2565 2e-59 194.0 COG1275@1|root,COG1275@2|Bacteria,1UYTE@1239|Firmicutes,2497H@186801|Clostridia,36FBE@31979|Clostridiaceae 186801|Clostridia P Voltage-dependent anion channel - - - ko:K11041 ko05150,map05150 - - - ko00000,ko00001,ko02042 2.A.16 - - SLAC1 k59_410179_1 1265505.ATUG01000001_gene4198 6.33e-52 177.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MIH6@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_278048_1 743299.Acife_0668 3.03e-111 340.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,2NDFW@225057|Acidithiobacillales 225057|Acidithiobacillales L DNA methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_672938_1 225849.swp_0931 2.02e-97 299.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,2QAED@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_1030800_1 1250006.JHZZ01000001_gene1112 1e-60 211.0 COG3250@1|root,COG3250@2|Bacteria,4NEP8@976|Bacteroidetes,1HZ78@117743|Flavobacteriia 976|Bacteroidetes G Glycosyl hydrolases family 2, sugar binding domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_377815_1 1121405.dsmv_2119 2.67e-11 63.2 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_933932_1 1454004.AW11_02007 4.38e-97 310.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KQ5Y@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria V MMPL family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_664071_3 1123401.JHYQ01000042_gene1321 5.42e-09 54.7 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,4611H@72273|Thiotrichales 72273|Thiotrichales I Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc k59_6259_1 1168034.FH5T_01860 1.48e-104 320.0 COG0018@1|root,COG0018@2|Bacteria,4NE7Q@976|Bacteroidetes,2FN06@200643|Bacteroidia 976|Bacteroidetes J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_270235_1 768671.ThimaDRAFT_3547 1.53e-67 222.0 COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,1S124@1236|Gammaproteobacteria 1236|Gammaproteobacteria G BT1 family - - - - - - - - - - - - BT1 k59_238420_1 1279009.ADICEAN_01177 1.12e-18 91.3 COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,47XXU@768503|Cytophagia 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,SdrD_B,SprB k59_1022560_1 1168034.FH5T_13730 3.32e-107 315.0 COG1120@1|root,COG1120@2|Bacteria,4PKG5@976|Bacteroidetes,2G2YD@200643|Bacteroidia 976|Bacteroidetes HP ATP-binding protein - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_990588_1 357276.EL88_18760 1.19e-18 87.4 2DPJD@1|root,332C5@2|Bacteria,4NVI7@976|Bacteroidetes,2FSC6@200643|Bacteroidia,4APAP@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_467636_1 313596.RB2501_01021 7.39e-99 308.0 COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,1HXJS@117743|Flavobacteriia 976|Bacteroidetes C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_858957_1 1123073.KB899241_gene1922 1.5e-24 94.7 COG3831@1|root,COG3831@2|Bacteria,1NGUF@1224|Proteobacteria,1T6H3@1236|Gammaproteobacteria,1X7H4@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - WGR k59_141380_1 1255043.TVNIR_3124 5.44e-80 245.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_41027_1 525897.Dbac_0167 1.3e-55 195.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2M8TZ@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.10,1.17.1.9 ko:K00123,ko:K05299 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_695922_1 42256.RradSPS_0937 8.37e-05 51.2 COG2199@1|root,COG5001@1|root,COG2199@2|Bacteria,COG5001@2|Bacteria 2|Bacteria T cyclic-guanylate-specific phosphodiesterase activity - - - - - - - - - - - - EAL,GAF,GGDEF,PAS,PAS_3,PAS_8,PAS_9,dCache_1 k59_565803_1 1249480.B649_11710 1.38e-78 237.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2YMBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_565803_2 1172190.M947_11195 1.2e-39 142.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2YMFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_337542_2 547042.BACCOPRO_02379 1.59e-17 82.0 COG1309@1|root,COG1309@2|Bacteria,4NQ99@976|Bacteroidetes,2FMT3@200643|Bacteroidia,4ANF8@815|Bacteroidaceae 976|Bacteroidetes K transcriptional regulator, TetR family - - - - - - - - - - - - TetR_N k59_206077_1 1142394.PSMK_20400 1.98e-25 105.0 COG0715@1|root,COG0715@2|Bacteria,2IYAE@203682|Planctomycetes 203682|Planctomycetes P COG0715 ABC-type nitrate sulfonate - - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_206077_2 1342299.Z947_2759 0.000248 44.3 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2TQT6@28211|Alphaproteobacteria,3ZWXB@60136|Sulfitobacter 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component nasE - - ko:K02050,ko:K15577 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17 - - BPD_transp_1 k59_1022568_1 1198232.CYCME_0904 6.35e-78 246.0 COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,460CG@72273|Thiotrichales 72273|Thiotrichales M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_630950_1 177437.HRM2_33350 1.76e-97 298.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,42PJV@68525|delta/epsilon subdivisions,2WKRG@28221|Deltaproteobacteria,2MKNF@213118|Desulfobacterales 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_302906_1 575540.Isop_1447 1.13e-89 275.0 COG0686@1|root,COG0686@2|Bacteria,2IXPP@203682|Planctomycetes 203682|Planctomycetes C Belongs to the AlaDH PNT family - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_925582_1 387093.SUN_1289 2.53e-68 231.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNMM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.6,3.6.3.8 ko:K01535,ko:K01537 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.2,3.A.3.3 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_760631_1 929558.SMGD1_0006 8.47e-88 268.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2YM8W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_760631_2 1123325.JHUV01000009_gene251 7.78e-18 81.3 COG1416@1|root,COG1416@2|Bacteria 2|Bacteria - - - - - ko:K09004 - - - - ko00000 - - - DrsE k59_141393_1 688246.Premu_2227 1.86e-18 92.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,2FWS8@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_598290_1 1408473.JHXO01000011_gene3144 4.63e-76 246.0 COG0556@1|root,COG0556@2|Bacteria,4NE6E@976|Bacteroidetes,2FNBD@200643|Bacteroidia 976|Bacteroidetes L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1022573_1 1163617.SCD_n00856 2.1e-14 73.9 COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,2VJ0K@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the peptidase M17 family - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_1022573_2 748247.AZKH_3737 2.44e-116 344.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KVK1@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_369663_1 932678.THERU_05745 1.65e-37 144.0 COG3419@1|root,COG3419@2|Bacteria,2G4K8@200783|Aquificae 200783|Aquificae NU Neisseria PilC beta-propeller domain - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_598294_1 1123326.JFBL01000008_gene504 6.8e-50 168.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2YMW1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_598294_2 749222.Nitsa_1014 9.6e-10 57.8 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,42PHC@68525|delta/epsilon subdivisions,2YNF2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H involved in molybdopterin and thiamine biosynthesis family 1 - - - - - - - - - - - - ThiF k59_433791_1 880072.Desac_0161 4.34e-109 328.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7Z@28221|Deltaproteobacteria,2MQJH@213462|Syntrophobacterales 28221|Deltaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - ko:K13283 - - - - ko00000,ko02000 2.A.4.7.1 - - Cation_efflux,ZT_dimer k59_630965_1 472759.Nhal_2432 1.47e-120 350.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales 135613|Chromatiales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_792304_1 234267.Acid_4435 1.18e-32 135.0 COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria 57723|Acidobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - - k59_433793_1 1198232.CYCME_2425 8.33e-54 183.0 COG3746@1|root,COG3746@2|Bacteria,1QYIH@1224|Proteobacteria,1T5GX@1236|Gammaproteobacteria,463WY@72273|Thiotrichales 72273|Thiotrichales P Phosphate-selective porin O and P - - - - - - - - - - - - Porin_O_P k59_500714_1 904144.AEJD01000005_gene294 2e-44 146.0 COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4D10E@85004|Bifidobacteriales 201174|Actinobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_238450_1 1168034.FH5T_04195 4.69e-64 197.0 COG0080@1|root,COG0080@2|Bacteria,4NM60@976|Bacteroidetes,2FRYX@200643|Bacteroidia 976|Bacteroidetes J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_238450_2 1168034.FH5T_04200 2e-65 202.0 COG0250@1|root,COG0250@2|Bacteria,4NF2X@976|Bacteroidetes,2FNJ6@200643|Bacteroidia 976|Bacteroidetes K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_858982_1 1123392.AQWL01000009_gene1127 8.68e-21 84.3 COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria,2VWV2@28216|Betaproteobacteria 28216|Betaproteobacteria S SMART zinc finger, CDGSH-type domain protein - - - - - - - - - - - - zf-CDGSH k59_858982_2 933262.AXAM01000083_gene770 2.82e-46 157.0 COG1123@1|root,COG1123@2|Bacteria,1QVC6@1224|Proteobacteria 1224|Proteobacteria P ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran k59_565827_1 391626.OAN307_c17510 1.3e-140 402.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - ko:K07492 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_41056_1 96561.Dole_1356 5.03e-46 166.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MHR5@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2 k59_925608_1 867903.ThesuDRAFT_01242 3.53e-39 149.0 COG1165@1|root,COG2267@1|root,COG1165@2|Bacteria,COG2267@2|Bacteria,1TRDB@1239|Firmicutes,24CPJ@186801|Clostridia 186801|Clostridia H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_2301 Abhydrolase_6,TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_664122_1 96561.Dole_3059 3.99e-160 463.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_6287_1 859657.RPSI07_2244 1.99e-05 52.4 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,1K4UW@119060|Burkholderiaceae 28216|Betaproteobacteria O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_990648_1 1537917.JU82_02950 8.88e-104 308.0 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,42NWV@68525|delta/epsilon subdivisions,2YMN9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - ko:K17051 - - - - ko00000,ko02000 5.A.3.8 - - Fer4_11 k59_337573_2 1123326.JFBL01000001_gene1232 1.41e-55 183.0 COG0745@1|root,COG0745@2|Bacteria,1N8XN@1224|Proteobacteria,42WCI@68525|delta/epsilon subdivisions,2YRPH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_337573_3 877455.Metbo_1329 3.37e-25 116.0 COG0642@1|root,COG2201@1|root,COG3920@1|root,arCOG02335@2157|Archaea,arCOG04921@2157|Archaea,arCOG06192@2157|Archaea 2157|Archaea T TIGRFAM PAS sensor protein - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA_2,PAS,PAS_10,PAS_3,PAS_9 k59_760670_2 944547.ABLL_1181 2.75e-16 84.0 COG2911@1|root,COG2911@2|Bacteria,1PBYT@1224|Proteobacteria,42T65@68525|delta/epsilon subdivisions,2YPPD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_500741_1 941449.dsx2_0659 6.46e-36 134.0 COG2204@1|root,COG2204@2|Bacteria,1RCHU@1224|Proteobacteria,42QWT@68525|delta/epsilon subdivisions,2WN23@28221|Deltaproteobacteria,2MAFK@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg,STAS,STAS_2 k59_6291_1 709032.Sulku_1856 2.94e-68 222.0 28NUA@1|root,2ZBSQ@2|Bacteria,1QE31@1224|Proteobacteria,42Z7U@68525|delta/epsilon subdivisions,2YR9R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_957204_1 1121924.ATWH01000012_gene1253 7.97e-56 189.0 COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4FNE3@85023|Microbacteriaceae 201174|Actinobacteria C FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_664134_1 1121439.dsat_2746 5.03e-46 173.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_565848_1 944547.ABLL_1541 1.06e-113 340.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42NHA@68525|delta/epsilon subdivisions,2YMYU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX1 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_500758_1 1408473.JHXO01000008_gene2793 4.78e-10 65.1 28I8D@1|root,2Z8B7@2|Bacteria,4NM23@976|Bacteroidetes,2FQ8C@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF4249) - - - - - - - - - - - - DUF4249 k59_369708_1 572544.Ilyop_0657 2e-46 155.0 COG3394@1|root,COG3394@2|Bacteria,37CA3@32066|Fusobacteria 32066|Fusobacteria G PFAM YdjC family protein - - 3.5.1.105 ko:K03478 - - - - ko00000,ko01000 - - - YdjC k59_369708_2 572544.Ilyop_0658 1.85e-30 118.0 COG0444@1|root,COG0444@2|Bacteria,378W5@32066|Fusobacteria 32066|Fusobacteria EP Belongs to the ABC transporter superfamily - - - - - - - - - - - - - k59_760690_1 1165841.SULAR_06838 4.69e-80 259.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2YMW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_173626_5 555793.WSK_3240 3.42e-15 72.8 COG3620@1|root,COG3620@2|Bacteria,1N78J@1224|Proteobacteria,2VGPZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_37 k59_173626_6 1123279.ATUS01000004_gene3022 8.19e-57 179.0 COG4683@1|root,COG4683@2|Bacteria,1MZIY@1224|Proteobacteria,1S686@1236|Gammaproteobacteria,1JB2Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Phage derived protein Gp49-like (DUF891) VY92_07350 - - - - - - - - - - - Gp49 k59_173626_7 751945.Theos_2007 5.33e-19 92.8 COG1597@1|root,COG1597@2|Bacteria,1WI0N@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I PFAM Diacylglycerol kinase, catalytic bmrU - - - - - - - - - - - DAGK_cat k59_173626_8 2340.JV46_04650 1.42e-185 525.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metallophosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_173626_9 96561.Dole_2249 1.61e-89 278.0 2E0M7@1|root,32W6F@2|Bacteria,1NB9Z@1224|Proteobacteria,42W6T@68525|delta/epsilon subdivisions,2WSFF@28221|Deltaproteobacteria,2MNT8@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_173626_10 1249627.D779_3696 0.0 1410.0 COG0642@1|root,COG0834@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2TY@135613|Chromatiales 135613|Chromatiales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg,SBP_bac_3 k59_173626_11 1249627.D779_3695 5.17e-175 498.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1WWBN@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - - - - - - - - - - HD_5,Response_reg k59_173626_13 1123367.C666_16500 1.73e-99 308.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2WEJE@28216|Betaproteobacteria,2KUR7@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_173626_14 395494.Galf_2014 1.22e-98 294.0 COG0745@1|root,COG0745@2|Bacteria,1PFQS@1224|Proteobacteria,2W982@28216|Betaproteobacteria,44WHJ@713636|Nitrosomonadales 28216|Betaproteobacteria K Two component transcriptional regulator, winged helix family - - - ko:K02483,ko:K07662 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_173626_15 525898.Sdel_2132 1.08e-28 119.0 COG5126@1|root,COG5126@2|Bacteria,1RKQX@1224|Proteobacteria 1224|Proteobacteria DTZ SMART Calcium-binding EF-hand-containing protein - - - - - - - - - - - - EF-hand_1,EF-hand_5,EF-hand_7,EF-hand_8 k59_173626_16 631362.Thi970DRAFT_04442 3.11e-137 397.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales 135613|Chromatiales S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_173626_17 1049564.TevJSym_ad00410 2.2e-48 157.0 2E8HY@1|root,332W0@2|Bacteria,1N9SS@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_173626_18 631362.Thi970DRAFT_03643 1.79e-155 463.0 COG4191@1|root,COG4191@2|Bacteria,1MXRR@1224|Proteobacteria,1RQ1E@1236|Gammaproteobacteria,1WW44@135613|Chromatiales 135613|Chromatiales T nitrogen fixation negative regulator NifL - - - - - - - - - - - - HATPase_c,PAS,PAS_9 k59_173626_19 765913.ThidrDRAFT_4408 2.54e-240 676.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,1WX1Q@135613|Chromatiales 135613|Chromatiales KT Fis Family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_173626_20 870187.Thini_0800 2.67e-271 753.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,1RRMW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Fer4_14,Nitro_FeMo-Co,Radical_SAM k59_173626_21 765912.Thimo_3249 1.21e-43 143.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,1WYVK@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - - k59_892552_1 387093.SUN_0113 1.14e-60 192.0 COG2932@1|root,COG2932@2|Bacteria,1RIP6@1224|Proteobacteria,42RJG@68525|delta/epsilon subdivisions,2YP8P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K phage repressor - - - - - - - - - - - - Peptidase_S24,Phage_CI_repr k59_892552_2 749222.Nitsa_1975 0.000474 42.4 COG1547@1|root,COG1547@2|Bacteria 2|Bacteria S Domain of unknown function (DUF309) - - - ko:K09763 - - - - ko00000 - - - DUF309 k59_991235_1 1424334.W822_18480 2.08e-86 267.0 COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,3T1YZ@506|Alcaligenaceae 28216|Betaproteobacteria S Benzoyl-CoA oxygenase boxB - 1.14.13.208 ko:K15512 ko00362,map00362 - R09555 RC01739 ko00000,ko00001,ko01000 - - - - k59_370210_1 572544.Ilyop_1688 5.35e-69 239.0 COG1452@1|root,COG1452@2|Bacteria,37983@32066|Fusobacteria 32066|Fusobacteria M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - k59_501326_1 1232410.KI421425_gene1547 3.33e-20 85.5 2EQ5T@1|root,32ZV0@2|Bacteria,1NFTI@1224|Proteobacteria,433CK@68525|delta/epsilon subdivisions,2WXC2@28221|Deltaproteobacteria,43VWA@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_501326_2 1042377.AFPJ01000023_gene661 3.45e-08 54.3 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria,465RQ@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_926098_1 314287.GB2207_09656 4.81e-49 177.0 COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,1RP6B@1236|Gammaproteobacteria,1J4RA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_238974_1 1168034.FH5T_01630 3.31e-156 442.0 COG0437@1|root,COG0437@2|Bacteria,4NIEP@976|Bacteroidetes 976|Bacteroidetes C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_11,Fer4_4 k59_1023076_1 1168034.FH5T_19470 6.8e-52 167.0 2ATIR@1|root,31J2R@2|Bacteria,4NR1Z@976|Bacteroidetes,2FUCT@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF4268) - - - - - - - - - - - - DUF4268 k59_1023076_2 1459636.NTE_02761 1.42e-23 95.9 COG3542@1|root,arCOG08247@2157|Archaea 2157|Archaea S Cupin superfamily (DUF985) - - - ko:K09705 - - - - ko00000 - - - Cupin_5 k59_211807_2 1408422.JHYF01000016_gene129 7.95e-09 54.3 COG4231@1|root,COG4231@2|Bacteria,1UHX9@1239|Firmicutes,24UZM@186801|Clostridia,36NRT@31979|Clostridiaceae 186801|Clostridia C 4Fe-4S dicluster domain - - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4 k59_308236_1 1286106.MPL1_07443 2.17e-81 245.0 COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,1T0AA@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer Membrane Lipoprotein blc4 - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_766409_1 443143.GM18_2915 8.01e-192 561.0 COG0553@1|root,COG0553@2|Bacteria,1MX26@1224|Proteobacteria,42P4C@68525|delta/epsilon subdivisions,2WKB5@28221|Deltaproteobacteria 28221|Deltaproteobacteria KL PFAM helicase domain protein - - - - - - - - - - - - Helicase_C,ResIII k59_274699_1 247634.GPB2148_898 9.62e-87 265.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA - - - - - - - - - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1027530_1 870187.Thini_4375 6.49e-34 126.0 COG3335@1|root,COG3335@2|Bacteria,1N2JC@1224|Proteobacteria,1S21X@1236|Gammaproteobacteria 1224|Proteobacteria L PFAM Rhodopirellula transposase - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_1027530_2 870187.Thini_4375 1.24e-50 174.0 COG3335@1|root,COG3335@2|Bacteria,1N2JC@1224|Proteobacteria,1S21X@1236|Gammaproteobacteria 1224|Proteobacteria L PFAM Rhodopirellula transposase - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_146840_2 194439.CT1970 9.09e-10 58.5 COG0071@1|root,COG0071@2|Bacteria,1FF1I@1090|Chlorobi 1090|Chlorobi O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_406752_1 177437.HRM2_44660 1.92e-84 263.0 COG2801@1|root,COG2801@2|Bacteria,1MUSB@1224|Proteobacteria,43AFH@68525|delta/epsilon subdivisions,2X5V7@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_604035_1 1484460.JSWG01000015_gene1093 2.81e-19 92.0 COG3291@1|root,COG3291@2|Bacteria,4PKTY@976|Bacteroidetes,1I1YW@117743|Flavobacteriia 976|Bacteroidetes S ASPIC and UnbV - - - - - - - - - - - - PKD,UnbV_ASPIC,VCBS k59_374511_1 765911.Thivi_4300 3.87e-82 265.0 COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,1SBWP@1236|Gammaproteobacteria,1WZ1F@135613|Chromatiales 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_45664_1 1163407.UU7_06798 3.07e-108 314.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1X3YF@135614|Xanthomonadales 135614|Xanthomonadales F GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_897263_1 643867.Ftrac_0917 1.45e-52 182.0 COG0513@1|root,COG0513@2|Bacteria,4NEJV@976|Bacteroidetes,47KSE@768503|Cytophagia 976|Bacteroidetes L Belongs to the DEAD box helicase family deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_112999_2 12957.ACEP26893-PA 1.61e-11 66.6 COG0389@1|root,KOG2095@2759|Eukaryota,38CM1@33154|Opisthokonta,3BCX5@33208|Metazoa,3CV7D@33213|Bilateria,41WRT@6656|Arthropoda,3SK32@50557|Insecta 33208|Metazoa L DNA-directed DNA polymerase activity. It is involved in the biological process described with DNA repair POLI GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0010225,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034644,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071494,GO:0071704,GO:0071897,GO:0090304,GO:0104004,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 ko:K03510 ko03460,map03460 - - - ko00000,ko00001,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_930814_1 686340.Metal_0516 5.12e-12 67.8 COG0530@1|root,COG0530@2|Bacteria,1PW8G@1224|Proteobacteria 1224|Proteobacteria P COG0530 Ca2 Na antiporter - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_930814_2 1163407.UU7_09735 2.77e-10 61.2 COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,1SBTI@1236|Gammaproteobacteria,1X8IX@135614|Xanthomonadales 135614|Xanthomonadales T Universal stress protein - - - - - - - - - - - - Usp k59_538902_1 83406.HDN1F_06440 5.86e-21 91.3 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC GO:0000105,GO:0003674,GO:0003824,GO:0004400,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - iECO111_1330.ECO111_2745,iSDY_1059.SDY_2220,iSSON_1240.SSON_2092 Aminotran_1_2 k59_9641_1 1209072.ALBT01000061_gene983 1.6e-37 135.0 COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1FHHG@10|Cellvibrio 1236|Gammaproteobacteria H Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway ubiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.3.40 ko:K03181 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R01302 RC00491,RC02148 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5638 Chor_lyase k59_604050_1 1211814.CAPG01000036_gene1934 5.54e-30 112.0 COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,4HH1E@91061|Bacilli,1ZFNE@1386|Bacillus 91061|Bacilli H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU38290 TMP-TENI k59_604050_2 97139.C824_02850 2.56e-119 349.0 COG2145@1|root,COG2145@2|Bacteria,1V1R6@1239|Firmicutes,248AC@186801|Clostridia,36DY6@31979|Clostridiaceae 186801|Clostridia H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) thiM - 2.7.1.50 ko:K00878 ko00730,ko01100,map00730,map01100 M00127 R04448 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HK k59_113008_2 1407650.BAUB01000033_gene2889 6.78e-19 83.6 COG0087@1|root,COG0087@2|Bacteria,1FZY5@1117|Cyanobacteria,1GYVF@1129|Synechococcus 1117|Cyanobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rpl3 - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_406761_1 935548.KI912159_gene3055 3.55e-92 289.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,43IRK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily gsiA1 - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_146867_1 1408322.JHYK01000007_gene2093 3.54e-23 103.0 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,27INP@186928|unclassified Lachnospiraceae 186801|Clostridia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_570764_1 999141.GME_06879 6.19e-86 265.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1XID6@135619|Oceanospirillales 135619|Oceanospirillales T Phosphate starvation-inducible protein PhoH phoH - - ko:K06217 - - - - ko00000 - - - PhoH k59_406763_1 1123367.C666_01405 9.05e-33 127.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVJ3@206389|Rhodocyclales 206389|Rhodocyclales JKL DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_406763_2 396595.TK90_1589 6.13e-72 219.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,1S3QM@1236|Gammaproteobacteria,1WYBE@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0178 family - - - ko:K09768 - - - - ko00000 - - - DUF188 k59_406763_3 768671.ThimaDRAFT_2144 8.32e-18 82.4 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_669609_1 1249627.D779_3935 1.05e-90 280.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P k59_864099_1 1121396.KB893080_gene912 4.85e-98 302.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2MJBX@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM FAD-dependent pyridine nucleotide-disulfide oxidoreductase, pyridine nucleotide-disulfide oxidoreductase dimerization region, Pyridine nucleotide-disulphide oxidoreductase, FAD NAD(P)-binding domain, Rhodanese-like protein - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,Rhodanese k59_374516_2 632335.Calkr_1725 3.62e-64 208.0 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,42GWN@68295|Thermoanaerobacterales 186801|Clostridia E TIGRFAM histidinol phosphate phosphatase HisJ family - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP k59_374516_3 1408439.JHXW01000003_gene1482 2.36e-70 221.0 COG1802@1|root,COG1802@2|Bacteria,37A3E@32066|Fusobacteria 32066|Fusobacteria K FCD domain - - - - - - - - - - - - FCD,GntR k59_274730_1 889378.Spiaf_2382 1.92e-91 278.0 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity nodI - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran k59_274730_2 1293054.HSACCH_01075 4.74e-76 231.0 COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,3WC1F@53433|Halanaerobiales 186801|Clostridia S Flavin reductase like domain flr - - - - - - - - - - - Flavin_Reduct k59_274730_3 177437.HRM2_13220 2.16e-230 662.0 COG0123@1|root,COG0454@1|root,COG0123@2|Bacteria,COG0456@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2MK5E@213118|Desulfobacterales 28221|Deltaproteobacteria BKQ Histone deacetylase - - - - - - - - - - - - Acetyltransf_1,Hist_deacetyl k59_374518_1 879212.DespoDRAFT_00124 1.88e-44 148.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_406767_1 631362.Thi970DRAFT_00095 1.39e-120 357.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,1WWJN@135613|Chromatiales 135613|Chromatiales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_732882_1 292415.Tbd_1222 3.45e-46 161.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria 28216|Betaproteobacteria EG of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_211830_1 1168034.FH5T_16740 1.08e-83 261.0 COG0507@1|root,COG0507@2|Bacteria,4NDYK@976|Bacteroidetes,2FNT1@200643|Bacteroidia 976|Bacteroidetes L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member recD2_2 - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - AAA_30,UvrD_C_2 k59_343132_1 572544.Ilyop_0551 7.62e-06 47.4 COG1301@1|root,COG1301@2|Bacteria,37BSI@32066|Fusobacteria 32066|Fusobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_538914_2 1123392.AQWL01000013_gene2382 6.46e-47 155.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,1KRPP@119069|Hydrogenophilales 119069|Hydrogenophilales C Produces ATP from ADP in the presence of a proton gradient across the membrane - - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_374542_1 153496.JNAB01000005_gene2777 1.77e-10 62.0 COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,2U1R9@28211|Alphaproteobacteria,2JZKY@204441|Rhodospirillales 204441|Rhodospirillales V Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_670324_2 477228.YO5_17140 8.15e-39 140.0 COG1152@1|root,COG1152@2|Bacteria,1QX31@1224|Proteobacteria,1T35A@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_767364_1 457396.CSBG_01957 5.25e-14 75.1 COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,36E0M@31979|Clostridiaceae 186801|Clostridia L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_767364_2 1168034.FH5T_12950 1.39e-116 359.0 COG2972@1|root,COG2972@2|Bacteria,4NGA0@976|Bacteroidetes 976|Bacteroidetes T signal transduction histidine kinase - - - - - - - - - - - - His_kinase k59_212593_1 1121403.AUCV01000001_gene694 5.48e-52 179.0 COG2108@1|root,COG2108@2|Bacteria,1MY1Y@1224|Proteobacteria,42MIQ@68525|delta/epsilon subdivisions,2WJD2@28221|Deltaproteobacteria,2MHQT@213118|Desulfobacterales 28221|Deltaproteobacteria S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM k59_407583_1 944547.ABLL_0508 1.01e-23 107.0 COG0642@1|root,COG3287@1|root,COG0642@2|Bacteria,COG3287@2|Bacteria,1NXDJ@1224|Proteobacteria,43CBD@68525|delta/epsilon subdivisions,2YQE7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T FIST N domain - - - - - - - - - - - - FIST,FIST_C,HATPase_c,HisKA k59_439801_1 935840.JAEQ01000001_gene3186 3.33e-27 112.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,43IEY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family aldA - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_439801_2 292414.TM1040_0097 1.34e-81 251.0 COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,2TS26@28211|Alphaproteobacteria,4NBB7@97050|Ruegeria 28211|Alphaproteobacteria H Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_113867_1 109760.SPPG_08431T0 5.39e-13 76.3 COG2966@1|root,2QPMM@2759|Eukaryota,39PMF@33154|Opisthokonta,3NWBX@4751|Fungi 4751|Fungi S Duf1212 domain membrane protein PRM10 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0012505,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034220,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0098656,GO:1903825,GO:1905039 - - - - - - - - - - ThrE,ThrE_2 k59_343862_1 452662.SJA_C1-07020 1.75e-26 113.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U0ME@28211|Alphaproteobacteria,2KEMY@204457|Sphingomonadales 204457|Sphingomonadales Q Bacterial Ig-like domain (group 3) - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - - k59_996774_1 929558.SMGD1_1060 1.22e-69 222.0 COG0475@1|root,COG0475@2|Bacteria,1N2RV@1224|Proteobacteria,43B2N@68525|delta/epsilon subdivisions,2YT5E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_637283_1 871968.DESME_02010 8.44e-15 78.6 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - PATR k59_1028365_1 1537917.JU82_04575 3.41e-59 183.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,42SGM@68525|delta/epsilon subdivisions,2YPJ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_212613_1 313603.FB2170_15578 1.13e-49 169.0 COG3509@1|root,COG3509@2|Bacteria,4NHFS@976|Bacteroidetes,1I3VW@117743|Flavobacteriia,2PIT7@252356|Maribacter 976|Bacteroidetes Q Esterase PHB depolymerase - - - ko:K03932 - - - - ko00000 - CE1 - Abhydrolase_2,Esterase_phd k59_767387_1 1168034.FH5T_16880 2.19e-65 221.0 COG1480@1|root,COG1480@2|Bacteria,4NEHV@976|Bacteroidetes,2FNT9@200643|Bacteroidia 976|Bacteroidetes S 7TM receptor with intracellular HD hydrolase - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_507531_2 287.DR97_243 1.46e-30 114.0 2BYGB@1|root,2ZI39@2|Bacteria,1P5HE@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF5086) - - - - - - - - - - - - DUF5086 k59_864913_1 861299.J421_4481 1.59e-100 300.0 COG0501@1|root,COG0501@2|Bacteria,1ZSNK@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_375341_1 387092.NIS_1824 5.7e-72 229.0 COG3439@1|root,COG3439@2|Bacteria,1Q0BS@1224|Proteobacteria,42RXE@68525|delta/epsilon subdivisions,2YP61@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_309061_1 400668.Mmwyl1_1055 2.76e-39 142.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XJA6@135619|Oceanospirillales 135619|Oceanospirillales O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_80861_1 981384.AEYW01000014_gene146 3.18e-47 164.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2U0BA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_2 k59_864916_1 1469607.KK073766_gene198 2.36e-12 72.0 COG3464@1|root,COG3464@2|Bacteria,1GIMZ@1117|Cyanobacteria,1HPQG@1161|Nostocales 1117|Cyanobacteria L Transposase - - - - - - - - - - - - - k59_963522_1 314287.GB2207_04154 1.44e-56 184.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1J5U2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component ybbA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_637294_1 1177154.Y5S_00455 2.16e-72 232.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XI7H@135619|Oceanospirillales 135619|Oceanospirillales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_147678_1 1235835.C814_03021 5.89e-07 52.8 COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia,3WG8E@541000|Ruminococcaceae 186801|Clostridia G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 k59_147680_1 948106.AWZT01000005_gene4514 1.52e-46 153.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2VR4W@28216|Betaproteobacteria,1K3S0@119060|Burkholderiaceae 28216|Betaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_147680_2 765913.ThidrDRAFT_3330 2.51e-46 155.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1WWJC@135613|Chromatiales 135613|Chromatiales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_996790_1 385682.AFSL01000040_gene227 6.95e-39 142.0 COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria 2|Bacteria L Transposase - - 2.7.7.4 ko:K00957,ko:K07497 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - HTH_23,HTH_29,PAPS_reduct,rve,rve_3 k59_832814_1 1094560.ME9_01116 2.29e-15 80.9 COG0008@1|root,COG1384@1|root,COG0008@2|Bacteria,COG1384@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,48TNX@772|Bartonellaceae 28211|Alphaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX1 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_832814_2 1485544.JQKP01000011_gene728 5.15e-60 199.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,44VP0@713636|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_733640_1 713586.KB900536_gene533 1.85e-77 245.0 COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria 1224|Proteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase2 k59_604841_1 644076.SCH4B_3579 3.42e-08 58.9 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,4NB9B@97050|Ruegeria 28211|Alphaproteobacteria G Alpha amylase, catalytic domain aglA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - Alpha-amylase,DUF3459,Malt_amylase_C k59_604841_2 1380393.JHVP01000003_gene1268 9.06e-63 206.0 COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria 201174|Actinobacteria IT Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Abhydrolase_1,Guanylate_cyc k59_796665_1 1168034.FH5T_11595 4.87e-146 415.0 COG2326@1|root,COG2326@2|Bacteria,4NFJ5@976|Bacteroidetes,2FND3@200643|Bacteroidia 976|Bacteroidetes S Polyphosphate kinase 2 (PPK2) - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_796665_2 1168034.FH5T_11600 4.73e-24 101.0 28TKX@1|root,2ZFUJ@2|Bacteria,4NKCT@976|Bacteroidetes,2G3EV@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_244273_1 1168034.FH5T_16735 1.45e-96 285.0 2C0G9@1|root,310GM@2|Bacteria,4NHU0@976|Bacteroidetes,2FN0C@200643|Bacteroidia 976|Bacteroidetes S COG NOG19144 non supervised orthologous group - - - - - - - - - - - - - k59_244273_2 1124780.ANNU01000024_gene3084 8.15e-28 113.0 COG0507@1|root,COG0507@2|Bacteria,4NDYK@976|Bacteroidetes,47MBF@768503|Cytophagia 976|Bacteroidetes L COGs COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member recD2_2 - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - AAA_30,UvrD_C_2 k59_113889_1 387093.SUN_0443 2.4e-57 187.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2YNCB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0330 IlvC,IlvN k59_348817_1 1125973.JNLC01000001_gene118 1.14e-21 95.9 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,3JU5J@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q MlaD protein MA20_08125 - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_348817_2 1121033.AUCF01000010_gene4454 1.06e-12 67.4 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2JQTF@204441|Rhodospirillales 204441|Rhodospirillales Q ATPases associated with a variety of cellular activities - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_869805_1 1123256.KB907926_gene865 4.07e-18 83.2 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1X4XY@135614|Xanthomonadales 135614|Xanthomonadales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_869805_2 1500890.JQNL01000001_gene2879 1.26e-21 95.5 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1X3FV@135614|Xanthomonadales 135614|Xanthomonadales M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_903093_1 313596.RB2501_05125 3.11e-87 276.0 COG2936@1|root,COG2936@2|Bacteria,4NFFB@976|Bacteroidetes,1HWJH@117743|Flavobacteriia 976|Bacteroidetes S X-Pro dipeptidyl-peptidase cocE - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_249175_1 314278.NB231_08783 4.8e-58 200.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1X0K4@135613|Chromatiales 135613|Chromatiales P Voltage gated chloride channel - - - - - - - - - - - - Voltage_CLC k59_903095_1 373903.Hore_05970 3.1e-99 306.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,3WAAY@53433|Halanaerobiales 186801|Clostridia NU PFAM type II secretion system protein E - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_1033061_1 485915.Dret_1994 1.37e-06 56.2 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2M8MD@213115|Desulfovibrionales 28221|Deltaproteobacteria U Type II and III secretion system protein - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - STN,Secretin,Secretin_N k59_249177_1 243231.GSU2792 2.58e-81 250.0 COG0500@1|root,COG0500@2|Bacteria,1QW0F@1224|Proteobacteria,43C56@68525|delta/epsilon subdivisions,2X7FJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_576543_1 754477.Q7C_2508 1.04e-26 110.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,45ZQ0@72273|Thiotrichales 72273|Thiotrichales M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_576543_2 335283.Neut_1216 1.82e-09 59.3 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,371ZN@32003|Nitrosomonadales 28216|Betaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_1001645_1 572477.Alvin_0815 3.37e-74 233.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1X2FT@135613|Chromatiales 135613|Chromatiales S PFAM Aminoglycoside phosphotransferase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_249181_1 1168034.FH5T_21045 1.13e-122 353.0 COG0149@1|root,COG0149@2|Bacteria,4NE2F@976|Bacteroidetes,2FNEK@200643|Bacteroidia 976|Bacteroidetes G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_576545_1 1300345.LF41_2649 2.03e-40 156.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales 135614|Xanthomonadales T Adenylate cyclase - - - - - - - - - - - - - k59_801536_1 105559.Nwat_0032 1.23e-26 103.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales 135613|Chromatiales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_801536_2 1280689.AUJC01000004_gene491 7.61e-17 78.2 COG0607@1|root,COG0607@2|Bacteria,1U0PW@1239|Firmicutes,24RKU@186801|Clostridia,36KH8@31979|Clostridiaceae 186801|Clostridia P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese,TusA k59_936175_1 1206557.I7KQR9_9CAUD 1.26e-32 119.0 4QB4E@10239|Viruses,4QVFU@35237|dsDNA viruses no RNA stage,4QR9J@28883|Caudovirales,4QN5F@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_444771_1 1165841.SULAR_08642 8.88e-153 456.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2YNRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU general secretion pathway protein D - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_968520_1 575788.VS_1878 4.38e-90 278.0 2EJBV@1|root,2ZZWQ@2|Bacteria,1P6SQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_968520_2 1192124.LIG30_0377 2.51e-127 377.0 28HQ7@1|root,2Z7XZ@2|Bacteria,1P3WR@1224|Proteobacteria,2W1SS@28216|Betaproteobacteria 28216|Betaproteobacteria S RES - - - - - - - - - - - - RES k59_313760_1 153948.NAL212_1477 4.66e-130 395.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales 28216|Betaproteobacteria I acyl-CoA dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_512363_1 631362.Thi970DRAFT_00756 4.99e-56 177.0 COG1607@1|root,COG1607@2|Bacteria,1RHNU@1224|Proteobacteria,1S4SW@1236|Gammaproteobacteria,1WYGR@135613|Chromatiales 135613|Chromatiales I PFAM thioesterase superfamily - - - - - - - - - - - - 4HBT k59_512363_2 1236959.BAMT01000005_gene81 1.31e-93 280.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI7D@28216|Betaproteobacteria,2KMA6@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_380258_1 1178825.ALIH01000002_gene883 6.06e-12 71.6 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,1HWKQ@117743|Flavobacteriia 976|Bacteroidetes S PFAM Family of - - - - - - - - - - - - TamB k59_51299_2 706191.PANA_3855 9.66e-23 92.8 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,3VYNS@53335|Pantoea 1236|Gammaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_444777_1 13333.ERN02872 9.13e-97 293.0 COG0055@1|root,KOG1350@2759|Eukaryota,37K5M@33090|Viridiplantae,3GCIP@35493|Streptophyta 35493|Streptophyta C ATP synthase subunit beta atpB - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_444777_2 981085.XP_010089872.1 6.73e-76 228.0 COG0355@1|root,KOG1758@2759|Eukaryota,37UFP@33090|Viridiplantae,3GIN2@35493|Streptophyta,4JUWB@91835|fabids 35493|Streptophyta C ATP synthase epsilon chain atpE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009507,GO:0009526,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009941,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0034220,GO:0034357,GO:0034641,GO:0034654,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055035,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_85867_1 526218.Sterm_1002 6.67e-41 139.0 COG2138@1|root,COG2138@2|Bacteria 2|Bacteria S sirohydrochlorin cobaltochelatase activity cbiX - 4.99.1.3 ko:K03795 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiX k59_738313_1 1121396.KB893001_gene3965 4.76e-15 75.1 COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria,2MPNG@213118|Desulfobacterales 28221|Deltaproteobacteria G AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_738313_2 1454004.AW11_02753 1.51e-32 125.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,1KR7J@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_609631_1 1249480.B649_11535 4.11e-35 129.0 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,42NWV@68525|delta/epsilon subdivisions,2YMN9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - ko:K17051 - - - - ko00000,ko02000 5.A.3.8 - - Fer4_11 k59_609631_2 1249480.B649_11530 8.18e-162 467.0 COG3474@1|root,COG3474@2|Bacteria,1R1KB@1224|Proteobacteria,42Z1J@68525|delta/epsilon subdivisions,2YRH9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c-552 DMSO reductase-like, heme-binding domain - - - ko:K17052 - - - - ko00000,ko02000 5.A.3.8 - - Cytochrom_C,EB_dh k59_609631_3 1249480.B649_11525 5.75e-25 98.2 2B1KW@1|root,31U2C@2|Bacteria,1QRVW@1224|Proteobacteria,42WG1@68525|delta/epsilon subdivisions,2YQCP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_1001674_1 318167.Sfri_2291 2.08e-81 267.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2QAEU@267890|Shewanellaceae 1236|Gammaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_707058_1 768671.ThimaDRAFT_0253 3.84e-08 57.4 COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,1S2WZ@1236|Gammaproteobacteria,1WWAG@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF533) - - - - - - - - - - - - DUF533 k59_185062_2 1165841.SULAR_06008 1.68e-42 149.0 COG4244@1|root,COG4244@2|Bacteria,1PJNV@1224|Proteobacteria,42TI9@68525|delta/epsilon subdivisions,2YQ43@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Membrane - - - - - - - - - - - - - k59_412474_1 1121013.P873_03880 4.86e-92 277.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1X3Z0@135614|Xanthomonadales 135614|Xanthomonadales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_609637_1 1254432.SCE1572_50085 6.12e-20 89.0 COG0008@1|root,COG0064@1|root,COG0008@2|Bacteria,COG0064@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2YUA8@29|Myxococcales 28221|Deltaproteobacteria J glutaminyl-tRNA glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C k59_609637_2 765912.Thimo_2078 4.84e-25 104.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1WW94@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_444789_1 290633.GOX1500 7.67e-14 67.4 COG4118@1|root,COG4118@2|Bacteria,1N187@1224|Proteobacteria,2UC48@28211|Alphaproteobacteria,2JU91@204441|Rhodospirillales 204441|Rhodospirillales D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox k59_444789_2 1380394.JADL01000004_gene6113 1.45e-51 167.0 COG1848@1|root,COG1848@2|Bacteria,1RA9A@1224|Proteobacteria,2U5AX@28211|Alphaproteobacteria,2JT5S@204441|Rhodospirillales 204441|Rhodospirillales S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - ko:K07064 - - - - ko00000 - - - PIN k59_1001677_3 1380355.JNIJ01000001_gene3948 7.36e-14 70.5 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria,3JTPW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,Guanylate_cyc,TIR_2 k59_642232_1 387093.SUN_0477 3.08e-194 545.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2YMEX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0183 SHMT k59_707076_1 1121405.dsmv_0012 1.41e-47 166.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_1033126_1 1168034.FH5T_10930 4.9e-84 258.0 COG0045@1|root,COG0045@2|Bacteria,4NFHA@976|Bacteroidetes,2FNFG@200643|Bacteroidia 976|Bacteroidetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_801581_1 1121459.AQXE01000001_gene2517 4.12e-116 364.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2M8IT@213115|Desulfovibrionales 28221|Deltaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - iAF987.Gmet_0119 Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_313803_1 457424.BFAG_00553 5.66e-74 236.0 COG1760@1|root,COG1760@2|Bacteria,4NENR@976|Bacteroidetes,2FMVE@200643|Bacteroidia,4AM7I@815|Bacteroidaceae 976|Bacteroidetes E COG1760 L-serine deaminase sdaA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_15559_1 794846.AJQU01000195_gene4794 9.15e-17 82.8 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,4B8QI@82115|Rhizobiaceae 28211|Alphaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1033136_2 485913.Krac_11000 2.06e-98 303.0 COG1609@1|root,COG1609@2|Bacteria 2|Bacteria K purine nucleotide biosynthetic process - - 5.3.1.12 ko:K01812,ko:K02529,ko:K16210 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000,ko02000,ko03000 2.A.2.5 - - DDE_Tnp_ISAZ013,Peripla_BP_3 k59_85902_1 563040.Saut_2072 6.87e-44 162.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YRKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0474 Cation transport ATPase - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_85902_2 563040.Saut_0742 3.16e-39 140.0 COG2404@1|root,COG2404@2|Bacteria,1NHB1@1224|Proteobacteria,42NB0@68525|delta/epsilon subdivisions,2YMQ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S phosphohydrolase (DHH superfamily) - - - ko:K07097 - - - - ko00000 - - - DHHA1 k59_51338_1 1168034.FH5T_09960 1.19e-09 58.9 COG0165@1|root,COG0165@2|Bacteria,4NFCY@976|Bacteroidetes,2FPNB@200643|Bacteroidia 976|Bacteroidetes E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Lyase_1 k59_51338_2 1168289.AJKI01000011_gene575 3.39e-12 65.5 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,2FNH9@200643|Bacteroidia,3XJ8U@558415|Marinilabiliaceae 976|Bacteroidetes E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1033141_1 870187.Thini_1265 3.91e-62 209.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,463NJ@72273|Thiotrichales 72273|Thiotrichales O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA - - - - - - - - - - - HSP70 k59_642254_1 742823.HMPREF9465_00300 6.86e-11 63.5 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,4PQQW@995019|Sutterellaceae 28216|Betaproteobacteria C Fumarate reductase flavoprotein C-term frdA - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_642254_2 929558.SMGD1_0557 2.19e-136 390.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2YMFW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family frdB - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_412497_1 1168034.FH5T_06450 4.1e-31 116.0 28NPZ@1|root,2ZBPQ@2|Bacteria,4NN3K@976|Bacteroidetes,2FPEH@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - OMP_b-brl_2 k59_412497_2 1168034.FH5T_06455 2.84e-128 369.0 COG1402@1|root,COG1402@2|Bacteria,4NF2C@976|Bacteroidetes,2FNIV@200643|Bacteroidia 976|Bacteroidetes S Creatinine amidohydrolase crnA - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_249226_1 1121904.ARBP01000012_gene1271 2.23e-52 183.0 COG0438@1|root,COG0438@2|Bacteria,4PKQN@976|Bacteroidetes,47K56@768503|Cytophagia 976|Bacteroidetes M PFAM glycogen synthase - - 2.4.1.11 ko:K00693 ko00500,ko01100,ko04151,ko04152,ko04910,ko04922,ko04931,map00500,map01100,map04151,map04152,map04910,map04922,map04931 - R00292 RC00005 ko00000,ko00001,ko01000,ko01003 - GT3 - Glycogen_syn k59_249226_2 1168034.FH5T_21925 1.48e-30 112.0 COG2825@1|root,COG2825@2|Bacteria,4NSCM@976|Bacteroidetes,2FU10@200643|Bacteroidia 976|Bacteroidetes M Outer membrane protein (OmpH-like) ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_85907_1 749222.Nitsa_1124 3.9e-116 357.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2YM8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_903140_1 1168034.FH5T_10945 2.02e-108 332.0 COG0855@1|root,COG0855@2|Bacteria,4NE3P@976|Bacteroidetes,2FM68@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_772389_2 2340.JV46_28190 7.06e-52 168.0 2AAM4@1|root,30ZYM@2|Bacteria,1RFTG@1224|Proteobacteria,1S4UQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF2384 k59_869870_1 1396418.BATQ01000171_gene2912 1.31e-53 183.0 COG0577@1|root,COG0577@2|Bacteria,46TM1@74201|Verrucomicrobia,2IVW0@203494|Verrucomicrobiae 203494|Verrucomicrobiae V MacB-like periplasmic core domain - - - - - - - - - - - - MacB_PCD k59_738375_1 1033732.CAHI01000005_gene1957 5.08e-53 177.0 COG1194@1|root,COG1194@2|Bacteria,4NDZY@976|Bacteroidetes,2FNMQ@200643|Bacteroidia,22V04@171550|Rikenellaceae 976|Bacteroidetes L NUDIX domain mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_738377_1 324925.Ppha_1695 1.11e-61 195.0 COG1945@1|root,COG1945@2|Bacteria,1FDKS@1090|Chlorobi 1090|Chlorobi E Belongs to the PdaD family pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC k59_185116_1 1121405.dsmv_3175 3.72e-52 179.0 COG0745@1|root,COG0745@2|Bacteria,1NE8H@1224|Proteobacteria,42NEH@68525|delta/epsilon subdivisions,2WK1M@28221|Deltaproteobacteria,2MHU4@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Cytidylate_kin2,Response_reg k59_903158_1 411684.HPDFL43_21664 6.93e-20 89.7 COG4976@1|root,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,2U5NY@28211|Alphaproteobacteria,43HEE@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Methyltransferase MA20_22060 - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,TPR_16,TPR_19,TPR_2,TPR_8 k59_968570_1 572544.Ilyop_0625 1.14e-88 263.0 COG1905@1|root,COG1905@2|Bacteria,37A55@32066|Fusobacteria 32066|Fusobacteria C PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit nuoE - 1.12.1.3 ko:K18330 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx k59_968570_3 572544.Ilyop_0627 0.0 1053.0 COG1894@1|root,COG1894@2|Bacteria,378S3@32066|Fusobacteria 32066|Fusobacteria C PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit hymB - 1.12.1.3 ko:K18331 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_968570_4 596151.DesfrDRAFT_0401 1.58e-32 125.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1MUM1@1224|Proteobacteria,42PI4@68525|delta/epsilon subdivisions,2WJ5A@28221|Deltaproteobacteria,2M7QX@213115|Desulfovibrionales 28221|Deltaproteobacteria C hydrogenase large subunit - - 1.12.1.3,1.12.7.2,1.6.5.3 ko:K00336,ko:K06441,ko:K18332 ko00190,ko01100,map00190,map01100 M00144 R00019,R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_9,NADH-G_4Fe-4S_3 k59_444856_1 883078.HMPREF9695_03197 3.17e-135 392.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,3JU2P@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain ivd2 - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_477770_1 765910.MARPU_08680 1.91e-31 122.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_445511_1 1123392.AQWL01000007_gene888 4.34e-05 45.1 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,1KSVK@119069|Hydrogenophilales 119069|Hydrogenophilales E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_445511_2 572477.Alvin_0360 3.26e-43 155.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales 135613|Chromatiales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_802334_1 1283300.ATXB01000001_gene1357 1.62e-48 169.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1XDIR@135618|Methylococcales 135618|Methylococcales O Mg chelatase-related protein - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_802334_2 1120999.JONM01000009_gene323 1.03e-17 80.9 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,2KPUI@206351|Neisseriales 206351|Neisseriales K Psort location Cytoplasmic, score 9.97 cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_707766_1 1500890.JQNL01000001_gene3334 4.56e-59 190.0 COG0316@1|root,COG0694@1|root,COG0316@2|Bacteria,COG0694@2|Bacteria,1MU8Y@1224|Proteobacteria,1RN7J@1236|Gammaproteobacteria,1X4F3@135614|Xanthomonadales 135614|Xanthomonadales C Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins nfuA - - ko:K07400 - - - - ko00000 - - - Fe-S_biosyn,NifU k59_52005_1 861299.J421_2432 1.74e-06 50.4 COG1595@1|root,COG1595@2|Bacteria,1ZT0A@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_223896_1 338963.Pcar_2988 2.99e-32 129.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,43S51@69541|Desulfuromonadales 28221|Deltaproteobacteria M Mechanosensitive ion channel mscS-2 - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_387413_1 1121405.dsmv_0063 1.79e-102 319.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MITU@213118|Desulfobacterales 28221|Deltaproteobacteria C CoA binding domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_1007770_1 1232410.KI421419_gene2478 2.26e-139 411.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,43RYP@69541|Desulfuromonadales 28221|Deltaproteobacteria C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2763 Aconitase,Aconitase_C k59_942661_1 553217.ENHAE0001_0495 1.72e-17 82.0 COG0204@1|root,COG0204@2|Bacteria,1RJMS@1224|Proteobacteria,1S71V@1236|Gammaproteobacteria,3NT8S@468|Moraxellaceae 1236|Gammaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_418480_2 631362.Thi970DRAFT_00323 2.76e-62 200.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1WVUY@135613|Chromatiales 135613|Chromatiales O PFAM ATPase associated with various cellular activities, AAA-5 - - 6.6.1.2 ko:K09882 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - AAA_5,CbbQ_C k59_22198_1 908612.HMPREF9720_0077 1.24e-78 249.0 COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,2FPDT@200643|Bacteroidia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_354791_1 314278.NB231_16473 1e-153 466.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales 135613|Chromatiales G alpha amylase catalytic - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_387430_1 1125700.HMPREF9195_01534 2.85e-32 118.0 COG1327@1|root,COG1327@2|Bacteria,2J7FW@203691|Spirochaetes 203691|Spirochaetes K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_354795_1 1123053.AUDG01000089_gene2259 1.25e-23 107.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1X1HN@135613|Chromatiales 135613|Chromatiales Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind k59_319802_1 713587.THITH_02005 3.53e-45 152.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_942675_1 1122621.ATZA01000005_gene621 8.77e-66 210.0 COG3507@1|root,COG3507@2|Bacteria,4NFU3@976|Bacteroidetes,1IQER@117747|Sphingobacteriia 976|Bacteroidetes G PFAM Glycosyl hydrolases family 43 - - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - Glyco_hydro_43,RicinB_lectin_2 k59_942675_2 1168034.FH5T_02105 7.19e-81 247.0 COG3507@1|root,COG3507@2|Bacteria,4NDUM@976|Bacteroidetes,2FM23@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 k59_713500_1 1469245.JFBG01000023_gene1280 9.07e-55 184.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1X2DA@135613|Chromatiales 135613|Chromatiales S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Reductase_C k59_387443_1 387092.NIS_0044 4.52e-62 191.0 COG4802@1|root,COG4802@2|Bacteria,1QYD3@1224|Proteobacteria,42PN1@68525|delta/epsilon subdivisions,2YMYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP PFAM Ferredoxin thioredoxin reductase catalytic beta chain - - - - - - - - - - - - FeThRed_B,Rhodanese k59_387443_2 387093.SUN_0488 4.07e-06 46.6 COG0607@1|root,COG0607@2|Bacteria,1PX2U@1224|Proteobacteria,434B7@68525|delta/epsilon subdivisions,2YSA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_807791_1 631362.Thi970DRAFT_03577 9.54e-80 254.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales 135613|Chromatiales T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_159801_1 1168034.FH5T_20520 9.9e-118 348.0 COG0738@1|root,COG0738@2|Bacteria,4NEYR@976|Bacteroidetes,2FP5F@200643|Bacteroidia 976|Bacteroidetes G L-fucose H symporter permease fucP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_1040107_1 396588.Tgr7_0483 8.96e-45 162.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales 135613|Chromatiales MU type I secretion outer membrane protein, TolC - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_387451_1 180332.JTGN01000004_gene2382 2.28e-22 100.0 COG1397@1|root,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,25DA4@186801|Clostridia 186801|Clostridia O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_418504_1 391626.OAN307_c42970 1.38e-63 215.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TZTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family tmd - 1.5.8.1,1.5.8.2 ko:K00317 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R01588,R02511 RC00185,RC00556,RC00557,RC00732 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_388236_3 1249627.D779_1371 2.82e-45 160.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_355632_1 572544.Ilyop_1161 3.65e-31 118.0 COG0473@1|root,COG0473@2|Bacteria,37872@32066|Fusobacteria 32066|Fusobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_355632_2 572544.Ilyop_1160 1.92e-51 176.0 COG0129@1|root,COG0129@2|Bacteria,378WV@32066|Fusobacteria 32066|Fusobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_520039_2 572544.Ilyop_0799 1.14e-154 442.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - - - - - - - - - - GNT-I,Glycos_transf_2 k59_520039_3 572544.Ilyop_0800 4.58e-167 478.0 COG0438@1|root,COG0438@2|Bacteria,37B6V@32066|Fusobacteria 32066|Fusobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_192466_1 999411.HMPREF1092_00344 3.92e-34 129.0 COG3944@1|root,COG3944@2|Bacteria,1V4XU@1239|Firmicutes,25CQW@186801|Clostridia,36WZD@31979|Clostridiaceae 186801|Clostridia M PFAM lipopolysaccharide biosynthesis - - - - - - - - - - - - GNVR,Wzz k59_192466_2 572544.Ilyop_0379 9.43e-26 103.0 COG0489@1|root,COG0489@2|Bacteria,37BKG@32066|Fusobacteria 32066|Fusobacteria D PFAM CobQ CobB MinD ParA nucleotide binding domain - - - - - - - - - - - - AAA_31 k59_943566_1 1463845.JOIG01000009_gene3223 3.14e-39 150.0 COG0515@1|root,COG0515@2|Bacteria,2GJTV@201174|Actinobacteria 201174|Actinobacteria KLT Serine threonine protein kinase - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ_C,Pkinase,TerD k59_320381_1 1122604.JONR01000086_gene1126 4.86e-07 50.4 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1X493@135614|Xanthomonadales 135614|Xanthomonadales P cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_320381_2 1121015.N789_01130 4.15e-76 239.0 COG0687@1|root,COG0687@2|Bacteria,1NKD7@1224|Proteobacteria,1RQPF@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Spermidine putrescine ABC transporter substrate-binding protein ydcS GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042618,GO:0042619,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071704,GO:0071705,GO:0098657,GO:1901440,GO:1901441,GO:1901576 - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - iECNA114_1301.ECNA114_1576,iECSF_1327.ECSF_1364,iEcHS_1320.EcHS_A1524 SBP_bac_8 k59_484105_1 1121396.KB893126_gene3 1.92e-61 197.0 COG0727@1|root,COG0727@2|Bacteria,1RDHS@1224|Proteobacteria,42RM7@68525|delta/epsilon subdivisions,2WNHD@28221|Deltaproteobacteria,2MJV8@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC k59_192482_1 1049564.TevJSym_aa01920 4.64e-72 228.0 COG0845@1|root,COG0845@2|Bacteria,1MWZ9@1224|Proteobacteria,1RM91@1236|Gammaproteobacteria,1JBVB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_D23 k59_714216_1 1117318.PRUB_10752 3.42e-68 233.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q06Y@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrF - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_419143_1 1313304.CALK_2278 7.84e-39 149.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_452937_1 1123253.AUBD01000006_gene805 8.2e-43 155.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1X4IP@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_808445_1 994573.T472_0205725 4.77e-113 337.0 COG4948@1|root,COG4948@2|Bacteria,1TUWS@1239|Firmicutes,249BH@186801|Clostridia 186801|Clostridia M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - 4.2.1.40 ko:K01706 ko00053,ko01100,map00053,map01100 - R02752,R08056 RC00543 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_552070_1 1165841.SULAR_03467 1.51e-98 299.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2YMTP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_584181_1 439235.Dalk_1460 3.43e-74 244.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MJ5T@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_192504_1 227377.CBU_0572 5.32e-08 56.2 COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,1RNFI@1236|Gammaproteobacteria,1JD4J@118969|Legionellales 118969|Legionellales E Belongs to the peptidase M17 family - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_192504_2 1249480.B649_07255 8.11e-97 291.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2YMDC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_484127_1 1177181.T9A_01556 1.66e-64 209.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XHMY@135619|Oceanospirillales 135619|Oceanospirillales IQ catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP fabB - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_484127_2 2903.EOD24086 0.000407 42.0 COG5640@1|root,KOG3627@2759|Eukaryota 2759|Eukaryota O serine-type endopeptidase activity - - - - - - - - - - - - MAM,TIR_2,Trypsin k59_876948_1 1123368.AUIS01000028_gene1313 6.68e-108 324.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-type antimicrobial peptide transport system, permease component macB - - ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 - - FtsX,MacB_PCD k59_93267_1 713586.KB900536_gene289 3.16e-48 176.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales 135613|Chromatiales V ABC-type transport system, involved in lipoprotein release, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_93267_2 247633.GP2143_01655 5.97e-05 45.1 COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,1S2XY@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_844323_2 1304885.AUEY01000026_gene3575 1.41e-88 286.0 COG0031@1|root,COG0215@1|root,COG0031@2|Bacteria,COG0215@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,2MIN1@213118|Desulfobacterales 28221|Deltaproteobacteria J cysteinyl-tRNA synthetase cysM - 2.5.1.47,6.1.1.16 ko:K01738,ko:K01883,ko:K12339 ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00359,M00360 R00897,R03132,R03601,R03650,R04859 RC00020,RC00055,RC00523,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,PALP,tRNA-synt_1e k59_584185_2 1168034.FH5T_17025 1.38e-87 264.0 COG0040@1|root,COG0040@2|Bacteria,4NDW8@976|Bacteroidetes,2FNGI@200643|Bacteroidia 976|Bacteroidetes F ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_552083_2 28258.KP05_12915 2.86e-12 68.6 COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,1S92A@1236|Gammaproteobacteria,1XMUW@135619|Oceanospirillales 135619|Oceanospirillales S DUF218 domain - - - - - - - - - - - - DUF218 k59_943595_1 1042376.AFPK01000074_gene2328 2.59e-115 349.0 COG0480@1|root,COG0480@2|Bacteria,4NE9X@976|Bacteroidetes,1HY04@117743|Flavobacteriia,40622@61432|unclassified Flavobacteriaceae 976|Bacteroidetes J Elongation factor G, domain IV fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_58844_1 1123368.AUIS01000001_gene1848 2.34e-19 86.7 28N6F@1|root,2ZBBB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_876957_2 1121405.dsmv_3212 1.38e-20 85.5 2EFC1@1|root,3394Y@2|Bacteria,1NB39@1224|Proteobacteria,42WHM@68525|delta/epsilon subdivisions,2WSCI@28221|Deltaproteobacteria,2MM1K@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_287902_1 1026882.MAMP_01427 4.18e-75 237.0 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,460VI@72273|Thiotrichales 72273|Thiotrichales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_287902_2 284031.JNXD01000001_gene5750 3.3e-13 71.6 COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE,GrpB k59_975291_1 1101190.ARWB01000001_gene1452 2.57e-95 291.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,36XBD@31993|Methylocystaceae 28211|Alphaproteobacteria C NADH-ubiquinone oxidoreductase chain 4, amino terminus nuoM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_452978_1 1537917.JU82_01570 2.18e-89 274.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2YNGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_520080_1 439235.Dalk_0615 3.98e-59 194.0 28MQN@1|root,2ZAZG@2|Bacteria,1MVVQ@1224|Proteobacteria,42MMM@68525|delta/epsilon subdivisions,2WKA1@28221|Deltaproteobacteria,2MHKP@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_682461_1 749222.Nitsa_2030 2.92e-12 66.6 COG2165@1|root,COG2165@2|Bacteria,1QUIP@1224|Proteobacteria,42VHZ@68525|delta/epsilon subdivisions,2YQA3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU TIGRFAM prepilin-type N-terminal cleavage methylation domain - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_745375_1 1038859.AXAU01000006_gene5552 4.73e-74 236.0 COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2U0H3@28211|Alphaproteobacteria,3JR1E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Serine aminopeptidase, S33 - - 2.7.10.2,3.3.2.9 ko:K01253,ko:K08253 ko00980,ko04976,ko05204,map00980,map04976,map05204 - R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_520081_1 472759.Nhal_0548 1.44e-117 353.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_484159_1 1249627.D779_1022 4.36e-40 151.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,1WX1Q@135613|Chromatiales 135613|Chromatiales KT Fis Family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_584198_1 1168034.FH5T_09570 3.41e-78 238.0 COG0283@1|root,COG0283@2|Bacteria,4NEMB@976|Bacteroidetes,2FM71@200643|Bacteroidia 976|Bacteroidetes F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin k59_584198_2 1408473.JHXO01000006_gene1183 1.33e-47 164.0 COG2067@1|root,COG2067@2|Bacteria,4NHNC@976|Bacteroidetes,2FP24@200643|Bacteroidia 976|Bacteroidetes I penicillin-binding protein porQ - - - - - - - - - - - PorP_SprF k59_745377_1 886379.AEWI01000210_gene2490 8.2e-52 177.0 28K2Q@1|root,2ZC5U@2|Bacteria,4PN2X@976|Bacteroidetes,2G13T@200643|Bacteroidia,3XJVB@558415|Marinilabiliaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_419180_1 713586.KB900536_gene2461 2.14e-74 242.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WXQN@135613|Chromatiales 135613|Chromatiales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_419181_1 883126.HMPREF9710_03036 3.6e-35 124.0 2CKE6@1|root,32ZEV@2|Bacteria,1NBRM@1224|Proteobacteria,2VX50@28216|Betaproteobacteria,477T3@75682|Oxalobacteraceae 28216|Betaproteobacteria S Family of unknown function (DUF5329) - - - - - - - - - - - - DUF5329 k59_714260_1 1223410.KN050846_gene1961 2.34e-96 300.0 COG4935@1|root,COG5276@1|root,COG4935@2|Bacteria,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1HZ43@117743|Flavobacteriia 976|Bacteroidetes O Zinc metalloprotease (Elastase) - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 k59_745385_1 713587.THITH_07385 3.2e-73 238.0 COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria 1224|Proteobacteria S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_388344_1 395493.BegalDRAFT_0856 5.25e-56 189.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,45ZNE@72273|Thiotrichales 72273|Thiotrichales O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_876983_1 765912.Thimo_3326 1.69e-177 521.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWXC@135613|Chromatiales 135613|Chromatiales G Belongs to the PEP-utilizing enzyme family - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_714263_1 1278306.KB906908_gene647 1.09e-41 144.0 COG0009@1|root,COG0009@2|Bacteria,378B4@32066|Fusobacteria 32066|Fusobacteria J Belongs to the SUA5 family - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_224767_1 570967.JMLV01000002_gene1775 2.89e-20 84.0 COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,2JTDG@204441|Rhodospirillales 204441|Rhodospirillales C COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_714267_1 1255043.TVNIR_2362 3.83e-41 138.0 28PZA@1|root,2ZCIS@2|Bacteria,1RCMD@1224|Proteobacteria,1SEW0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_287905_1 1293054.HSACCH_02181 4.76e-16 80.5 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3WACD@53433|Halanaerobiales 186801|Clostridia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_287905_2 1218076.BAYB01000001_gene40 2.51e-47 171.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,1K1A3@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_779540_2 335543.Sfum_2402 1.21e-10 64.3 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_453027_1 1357399.HMPREF2087_01115 1.58e-25 101.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42SHQ@68525|delta/epsilon subdivisions 1224|Proteobacteria K Belongs to the Fur family fur GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03711,ko:K09825 - - - - ko00000,ko03000 - - - FUR k59_453027_2 273121.WS1995 1.27e-72 221.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2YMW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Alkyl hydroperoxide reductase ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_22915_2 469383.Cwoe_0788 2.59e-07 56.6 COG1573@1|root,COG1573@2|Bacteria,2HNTA@201174|Actinobacteria,4CQ1J@84995|Rubrobacteria 84995|Rubrobacteria L Uracil DNA glycosylase superfamily - - - - - - - - - - - - UDG k59_490790_2 572544.Ilyop_0252 2.1e-149 427.0 COG1281@1|root,COG1281@2|Bacteria,37922@32066|Fusobacteria 32066|Fusobacteria O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_490790_3 105559.Nwat_1518 1.01e-07 56.6 COG1366@1|root,COG1366@2|Bacteria,1RIIT@1224|Proteobacteria,1S713@1236|Gammaproteobacteria,1X1XW@135613|Chromatiales 135613|Chromatiales T Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) - - - - - - - - - - - - STAS k59_490790_4 469616.FMAG_00637 2.45e-115 337.0 COG0084@1|root,COG0084@2|Bacteria,378Z6@32066|Fusobacteria 32066|Fusobacteria L hydrolase, TatD family - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1013856_1 177437.HRM2_15730 1.13e-58 199.0 COG2203@1|root,COG4191@1|root,COG5000@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1R3RN@1224|Proteobacteria,42P11@68525|delta/epsilon subdivisions,2WJEK@28221|Deltaproteobacteria,2MN0A@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF,HAMP,HATPase_c,PAS_4 k59_425419_1 1249627.D779_2141 7.88e-13 62.8 2E3CD@1|root,32YBP@2|Bacteria,1N8PD@1224|Proteobacteria,1SCSK@1236|Gammaproteobacteria,1WZ7C@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_425419_2 1255043.TVNIR_0862 8.45e-48 163.0 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales 135613|Chromatiales Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_621625_1 1007103.AFHW01000033_gene2189 6.57e-14 75.9 COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,4HAV4@91061|Bacilli,26SQ0@186822|Paenibacillaceae 91061|Bacilli D Belongs to the SEDS family ftsW - - - - - - - - - - - FTSW_RODA_SPOVE k59_752422_1 1168034.FH5T_12150 8.54e-66 218.0 COG0658@1|root,COG0658@2|Bacteria,4NEJH@976|Bacteroidetes,2FPT6@200643|Bacteroidia 976|Bacteroidetes S ComEC Rec2-like protein comEC - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131 k59_196629_1 1042377.AFPJ01000036_gene1233 1.25e-128 387.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_131221_2 177439.DP2396 4.16e-45 151.0 COG2731@1|root,COG2731@2|Bacteria,1N5B5@1224|Proteobacteria,42TJQ@68525|delta/epsilon subdivisions,2WR4J@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Domain of unknown function (DUF386) - - - - - - - - - - - - DUF386 k59_294719_1 765912.Thimo_2866 3.42e-101 326.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_327493_1 387093.SUN_2018 4.02e-66 213.0 2E36N@1|root,32Y6C@2|Bacteria,1NX8V@1224|Proteobacteria,42UV2@68525|delta/epsilon subdivisions,2YSF3@29547|Epsilonproteobacteria 68525|delta/epsilon subdivisions - - - - - - - - - - - - - - - k59_490795_1 202952.BBLI01000030_gene2218 8.9e-155 504.0 COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,3NN17@468|Moraxellaceae 1236|Gammaproteobacteria Q Bacterial Ig-like domain (group 3) - - - - - - - - - - - - Big_3_2,Big_3_3,VCBS k59_981139_1 1537917.JU82_01035 1.67e-27 111.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2YRHY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O NfeD-like C-terminal, partner-binding - - - - - - - - - - - - NfeD k59_981139_2 1165841.SULAR_03537 7.33e-131 377.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2YMHX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Membrane protease subunits - - - - - - - - - - - - Band_7 k59_981139_3 1537917.JU82_04840 8.06e-10 58.5 COG2863@1|root,COG2863@2|Bacteria,1NBPD@1224|Proteobacteria,42VXS@68525|delta/epsilon subdivisions,2YQ9N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cytochrome - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_752437_1 665571.STHERM_c18190 7.31e-92 281.0 COG0673@1|root,COG0673@2|Bacteria,2J5J5@203691|Spirochaetes 203691|Spirochaetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_360149_1 1165841.SULAR_09859 2.85e-102 308.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2YMUK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_131234_1 1319815.HMPREF0202_02293 3.63e-29 112.0 COG2008@1|root,COG2008@2|Bacteria,378IZ@32066|Fusobacteria 32066|Fusobacteria E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_490804_1 397291.C804_04458 8.13e-05 45.4 COG1216@1|root,COG1216@2|Bacteria,1VD9J@1239|Firmicutes 1239|Firmicutes S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_490804_2 1380355.JNIJ01000037_gene5273 1.55e-14 73.6 COG1266@1|root,COG1266@2|Bacteria,1QPQ0@1224|Proteobacteria,2TTX7@28211|Alphaproteobacteria,3JSCR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_196650_1 520709.F985_03140 3.84e-61 201.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,3NIPS@468|Moraxellaceae 1236|Gammaproteobacteria I Belongs to the thiolase family paaJ GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0006805,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016740,GO:0016746,GO:0016747,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0033554,GO:0033812,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 2.3.1.16,2.3.1.174,2.3.1.223,2.3.1.9 ko:K00626,ko:K00632,ko:K02615 ko00071,ko00072,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00360,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095,R09839 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955,RC03003 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_164008_2 1049564.TevJSym_ah00500 1.57e-16 79.3 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1JBY1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_360153_1 1121289.JHVL01000040_gene3172 9.01e-32 119.0 COG1309@1|root,COG1309@2|Bacteria,1VF0Y@1239|Firmicutes,24N8C@186801|Clostridia,36M7G@31979|Clostridiaceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_752445_1 1168034.FH5T_10385 2.36e-102 328.0 COG1277@1|root,COG1277@2|Bacteria,4NI5T@976|Bacteroidetes,2FNVZ@200643|Bacteroidia 976|Bacteroidetes E ABC-type transport system involved in multi-copper enzyme maturation permease component - - - - - - - - - - - - Peptidase_M1 k59_719701_2 1408439.JHXW01000006_gene1004 1.26e-129 376.0 COG2996@1|root,COG2996@2|Bacteria,37986@32066|Fusobacteria 32066|Fusobacteria S S1 domain - - - ko:K00243 - - - - ko00000 - - - S1,S1_2 k59_719701_3 1408422.JHYF01000004_gene1611 1.94e-11 62.8 COG3976@1|root,COG3976@2|Bacteria,1VFG0@1239|Firmicutes,24RHT@186801|Clostridia,36MVQ@31979|Clostridiaceae 186801|Clostridia S PFAM FMN-binding domain - - - - - - - - - - - - FMN_bind k59_915839_1 1165841.SULAR_06888 2.23e-52 179.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2YMRG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H folylpolyglutamate synthase folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_588998_1 1198232.CYCME_1627 6.55e-41 144.0 COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,1SZ1Z@1236|Gammaproteobacteria,462EK@72273|Thiotrichales 72273|Thiotrichales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_360161_1 1165841.SULAR_07460 4.06e-35 131.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,42MQ3@68525|delta/epsilon subdivisions,2YMPC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_654367_1 387093.SUN_2331 5.59e-43 142.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,42RHR@68525|delta/epsilon subdivisions,2YP6F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_654367_2 749222.Nitsa_0108 2.84e-35 121.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,42TGC@68525|delta/epsilon subdivisions,2YQA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_294751_2 655815.ZPR_2939 1.83e-45 154.0 COG0702@1|root,COG0702@2|Bacteria,4NIXP@976|Bacteroidetes,1HZVX@117743|Flavobacteriia 976|Bacteroidetes GM Pfam NmrA-like family - - - - - - - - - - - - NAD_binding_10 k59_556274_1 1121405.dsmv_2390 1.29e-146 425.0 COG3385@1|root,COG3385@2|Bacteria,1R8CS@1224|Proteobacteria,42P9F@68525|delta/epsilon subdivisions,2WKTA@28221|Deltaproteobacteria,2MJAY@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_5,DDE_Tnp_2 k59_131256_1 305900.GV64_13385 1.49e-17 77.4 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,1S98P@1236|Gammaproteobacteria,1XKU7@135619|Oceanospirillales 135619|Oceanospirillales I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_131256_2 472759.Nhal_2439 1.53e-67 212.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1WXFG@135613|Chromatiales 135613|Chromatiales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_621656_1 177437.HRM2_17260 4.11e-173 508.0 COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria,433HE@68525|delta/epsilon subdivisions,2WYHG@28221|Deltaproteobacteria,2MP7M@213118|Desulfobacterales 28221|Deltaproteobacteria L Domain of unknown function (DUF4277) - - - - - - - - - - - - DUF4277 k59_556278_1 243924.LT42_14950 1.37e-48 164.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria 1236|Gammaproteobacteria M involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - iPC815.YPO1056 Acetyltransf_11,Hexapep k59_262065_1 118166.JH976537_gene1439 1.32e-16 86.7 COG0845@1|root,COG0845@2|Bacteria,1FZZ9@1117|Cyanobacteria,1H77A@1150|Oscillatoriales 1117|Cyanobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_D23 k59_360189_1 857087.Metme_4436 7.8e-98 292.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1XDX3@135618|Methylococcales 135618|Methylococcales S Belongs to the UPF0276 family - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_164039_1 105559.Nwat_0045 1.3e-211 621.0 COG1474@1|root,COG1474@2|Bacteria,1R5I2@1224|Proteobacteria,1RXXF@1236|Gammaproteobacteria,1WVZI@135613|Chromatiales 135613|Chromatiales LO Belongs to the peptidase S16 family - - - - - - - - - - - - - k59_294765_1 572544.Ilyop_0196 3.82e-64 209.0 COG0015@1|root,COG0015@2|Bacteria,378VV@32066|Fusobacteria 32066|Fusobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_294765_3 247490.KSU1_C0338 1.88e-32 142.0 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,2J515@203682|Planctomycetes 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE3,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg k59_294765_5 1319815.HMPREF0202_01649 1.11e-20 89.0 COG0454@1|root,COG0456@2|Bacteria,37AVB@32066|Fusobacteria 32066|Fusobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_7 k59_294765_6 1319815.HMPREF0202_01650 5.06e-64 206.0 COG0681@1|root,COG0681@2|Bacteria,378A6@32066|Fusobacteria 32066|Fusobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_490833_1 1165841.SULAR_03747 7.52e-145 422.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,42M9F@68525|delta/epsilon subdivisions,2YNB8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G PFAM phosphoglucomutase phosphomannomutase alpha beta alpha domain I pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_752487_1 289376.THEYE_A0072 1.34e-60 203.0 COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae 40117|Nitrospirae M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_65922_1 1172190.M947_10480 2.11e-55 179.0 28WAS@1|root,2ZIB8@2|Bacteria,1NBB7@1224|Proteobacteria,42P2G@68525|delta/epsilon subdivisions,2YNQ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_229435_1 360911.EAT1b_1102 2.06e-75 254.0 COG0210@1|root,COG0551@1|root,COG0210@2|Bacteria,COG0551@2|Bacteria,1V03X@1239|Firmicutes,4HTCR@91061|Bacilli 91061|Bacilli L Topoisomerase DNA binding C4 zinc finger - - 3.6.4.12 ko:K03658 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C,zf-C4_Topoisom k59_883195_1 1464048.JNZS01000033_gene2794 2.75e-48 170.0 COG1075@1|root,COG1075@2|Bacteria,2HXFM@201174|Actinobacteria,4DI5G@85008|Micromonosporales 201174|Actinobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - Lipase_2 k59_556293_1 762376.AXYL_04975 4.47e-83 264.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,3T1BT@506|Alcaligenaceae 28216|Betaproteobacteria FP Exopolyphosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_392889_1 572544.Ilyop_1865 3.55e-89 270.0 COG1136@1|root,COG1136@2|Bacteria,379EK@32066|Fusobacteria 32066|Fusobacteria V ABC transporter, ATP-binding protein - - - - - - - - - - - - ABC_tran k59_360199_1 1198232.CYCME_2282 2.02e-81 257.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,45ZR5@72273|Thiotrichales 72273|Thiotrichales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_817756_2 983548.Krodi_0173 2.53e-24 103.0 COG1132@1|root,COG1132@2|Bacteria,4NEAG@976|Bacteroidetes,1HY1E@117743|Flavobacteriia,37EDJ@326319|Dokdonia 976|Bacteroidetes V ABC transporter transmembrane region - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_883197_1 572477.Alvin_1530 3.03e-22 96.3 COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,1MWYQ@1224|Proteobacteria,1S2YD@1236|Gammaproteobacteria,1WY4X@135613|Chromatiales 135613|Chromatiales T low molecular weight - - 1.20.4.1 ko:K03741,ko:K03892 - - - - ko00000,ko01000,ko03000 - - - HTH_5,LMWPc k59_458956_1 1414720.CBYM010000039_gene1606 1.58e-144 420.0 COG0409@1|root,COG0409@2|Bacteria,1TPM7@1239|Firmicutes,248EX@186801|Clostridia,36FKI@31979|Clostridiaceae 186801|Clostridia O hydrogenase expression formation protein HypD hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_458956_2 1449355.JQNR01000003_gene828 3.19e-14 69.3 COG0298@1|root,COG0298@2|Bacteria,2IMSQ@201174|Actinobacteria 201174|Actinobacteria O Hydrogenase expression formation protein hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_458956_3 1291050.JAGE01000001_gene3028 4.97e-39 150.0 COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,3WHQ8@541000|Ruminococcaceae 186801|Clostridia O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_851242_1 596320.NEIFL0001_0501 6.22e-46 164.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VH24@28216|Betaproteobacteria,2KPGX@206351|Neisseriales 206351|Neisseriales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_393568_1 1168034.FH5T_06170 5.11e-18 84.0 COG1538@1|root,COG1538@2|Bacteria,4NEMI@976|Bacteroidetes,2FMRJ@200643|Bacteroidia 976|Bacteroidetes MU Psort location OuterMembrane, score - - - - - - - - - - - - OEP k59_393568_2 1168034.FH5T_06165 1.54e-89 290.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FWCM@200643|Bacteroidia 976|Bacteroidetes V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_785696_1 866536.Belba_3829 2.42e-157 476.0 COG0557@1|root,COG0557@2|Bacteria,4NE7T@976|Bacteroidetes,47JK7@768503|Cytophagia 976|Bacteroidetes J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573,ko:K12585 ko03018,map03018 M00391 - - ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_818427_1 598659.NAMH_1472 1.77e-32 123.0 COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2YNKT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L tigr02757 - - - - - - - - - - - - DUF2400 k59_720434_1 1121904.ARBP01000031_gene577 2.79e-21 91.3 COG1510@1|root,COG1510@2|Bacteria,4NSVR@976|Bacteroidetes 976|Bacteroidetes K regulation of RNA biosynthetic process - - - - - - - - - - - - HTH_5 k59_230142_1 997296.PB1_04670 9.68e-110 322.0 COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H9WY@91061|Bacilli,1ZB2E@1386|Bacillus 91061|Bacilli E COG1126 ABC-type polar amino acid transport system, ATPase component - - 3.6.3.21 ko:K02028,ko:K10038 ko02010,map02010 M00227,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.2 - - ABC_tran k59_491527_1 743299.Acife_1432 1.99e-24 99.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,2NCWK@225057|Acidithiobacillales 225057|Acidithiobacillales F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_426129_1 411476.BACOVA_05267 1.25e-11 66.6 COG0810@1|root,COG0810@2|Bacteria,4NSYT@976|Bacteroidetes,2FP10@200643|Bacteroidia,4AMQ3@815|Bacteroidaceae 976|Bacteroidetes M Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarbopepD_reg_2,TonB_C k59_458966_1 882378.RBRH_03571 8.2e-66 210.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,1K0E6@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1014569_1 85643.Tmz1t_1492 1.73e-72 225.0 COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,2VURZ@28216|Betaproteobacteria,2KYHM@206389|Rhodocyclales 206389|Rhodocyclales C Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_197364_1 768671.ThimaDRAFT_2072 2.17e-80 260.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RX01@1236|Gammaproteobacteria,1X08Y@135613|Chromatiales 135613|Chromatiales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_197364_2 631362.Thi970DRAFT_04503 0.000195 43.1 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1X0NZ@135613|Chromatiales 135613|Chromatiales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_785697_3 877455.Metbo_1478 7.16e-13 75.9 COG0484@1|root,COG2319@1|root,arCOG01917@1|root,arCOG01917@2157|Archaea,arCOG02491@2157|Archaea,arCOG02846@2157|Archaea 2157|Archaea O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - - - - - - - - - - Anticodon_1,Band_7_1,DUF835,PEGA,PQQ_2,zinc_ribbon_2 k59_785697_4 1219077.VAZ01S_005_00280 6.46e-47 155.0 2B4QX@1|root,31XH7@2|Bacteria,1RGZ9@1224|Proteobacteria,1S5XZ@1236|Gammaproteobacteria,1XYFM@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_393578_1 1144313.PMI10_00967 8.65e-39 143.0 28M32@1|root,2ZAHE@2|Bacteria,4NM0S@976|Bacteroidetes,1I7W0@117743|Flavobacteriia,2NVIX@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - WG_beta_rep k59_818441_1 387093.SUN_1634 7.17e-77 234.0 COG0745@1|root,COG0745@2|Bacteria,1Q4KJ@1224|Proteobacteria,42ZD8@68525|delta/epsilon subdivisions,2YRA5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Trans_reg_C k59_429561_4 292459.STH1384 3.69e-75 249.0 COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia 186801|Clostridia L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_136441_1 1172190.M947_09590 1.54e-71 242.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YMMN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_70446_1 340099.Teth39_1674 4.71e-48 165.0 COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,42FJX@68295|Thermoanaerobacterales 186801|Clostridia C Belongs to the PdxA family pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_70446_2 572544.Ilyop_0655 0.0 1040.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,378RK@32066|Fusobacteria 32066|Fusobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_70446_3 469617.FUAG_00722 1.24e-138 400.0 COG1210@1|root,COG1210@2|Bacteria,37915@32066|Fusobacteria 32066|Fusobacteria M Psort location Cytoplasmic, score galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_756445_1 1206732.BAGD01000016_gene18 1.42e-10 68.9 COG5412@1|root,COG5412@2|Bacteria,2GNNQ@201174|Actinobacteria,4G9E7@85025|Nocardiaceae 201174|Actinobacteria M phage tail tape measure protein - - - - - - - - - - - - PhageMin_Tail,SLT k59_659431_1 1442598.JABW01000025_gene1145 2.42e-08 55.1 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2YMZV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM SNARE associated Golgi protein dedA - - - - - - - - - - - SNARE_assoc k59_659431_2 929558.SMGD1_1570 4.26e-22 94.4 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2YMJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_887135_1 765913.ThidrDRAFT_2941 7.14e-30 118.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WX0Q@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_593098_1 931626.Awo_c14820 3.27e-130 379.0 COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,25V9U@186806|Eubacteriaceae 186801|Clostridia C Metallo-beta-lactamase domain protein norV - - - - - - - - - - - Flavodoxin_1,Lactamase_B k59_495624_1 1165841.SULAR_10114 1.75e-130 381.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2YMCM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_463458_1 1168034.FH5T_06230 3.51e-107 316.0 COG0652@1|root,COG0652@2|Bacteria,4NGT6@976|Bacteroidetes,2FMZ6@200643|Bacteroidia 976|Bacteroidetes O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K01802,ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_234140_1 1121405.dsmv_1623 2.01e-88 282.0 COG0306@1|root,COG0306@2|Bacteria,1QAR3@1224|Proteobacteria,42P0C@68525|delta/epsilon subdivisions,2WJWM@28221|Deltaproteobacteria,2MINM@213118|Desulfobacterales 28221|Deltaproteobacteria P Phosphate transporter family - - - - - - - - - - - - PHO4 k59_429576_1 1122614.JHZF01000013_gene3408 1.3e-57 198.0 COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,2PCSG@252301|Oceanicola 28211|Alphaproteobacteria E Belongs to the peptidase M17 family pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_429576_2 1123367.C666_14505 0.000191 43.5 COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,2VRKF@28216|Betaproteobacteria,2KWF3@206389|Rhodocyclales 206389|Rhodocyclales S Cobalt uptake substrate-specific transmembrane region - - - - - - - - - - - - CbiM k59_887145_1 1172190.M947_00340 1.71e-59 198.0 COG1538@1|root,COG1538@2|Bacteria,1QWWG@1224|Proteobacteria,42PH5@68525|delta/epsilon subdivisions,2YMHH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU outer membrane efflux protein - - - - - - - - - - - - OEP k59_463463_1 1177181.T9A_01157 1.21e-110 333.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RY35@1236|Gammaproteobacteria,1XNQ7@135619|Oceanospirillales 135619|Oceanospirillales E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_855695_1 471870.BACINT_04105 2.7e-72 234.0 COG1621@1|root,COG1621@2|Bacteria,4NGJC@976|Bacteroidetes,2FP75@200643|Bacteroidia,4ANPW@815|Bacteroidaceae 976|Bacteroidetes G beta-fructofuranosidase activity - - - - - - - - - - - - - k59_464045_1 760011.Spico_1036 5.97e-42 140.0 COG0432@1|root,COG0432@2|Bacteria,2J7PN@203691|Spirochaetes 203691|Spirochaetes S Secondary thiamine-phosphate synthase enzyme - - - - - - - - - - - - UPF0047 k59_1019163_1 1073999.BN137_1293 1.82e-90 286.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_529288_1 1168034.FH5T_06780 2.14e-189 550.0 COG0058@1|root,COG0058@2|Bacteria,4NGR1@976|Bacteroidetes,2FNN5@200643|Bacteroidia 976|Bacteroidetes G alpha-glucan phosphorylase glgP - 2.4.1.1,2.4.1.11,2.4.1.8 ko:K00688,ko:K00691,ko:K16153 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R00292,R01555,R02111 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003 - GH65,GT3,GT35 - DUF3417,Glycogen_syn,Phosphorylase k59_660008_1 96561.Dole_2799 2.29e-25 106.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2MKKR@213118|Desulfobacterales 28221|Deltaproteobacteria I Alpha beta hydrolase agmH - - - - - - - - - - - Hydrolase_4 k59_823101_1 172045.KS04_21100 7.82e-11 63.5 COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,1HXN5@117743|Flavobacteriia,34PJ0@308865|Elizabethkingia 976|Bacteroidetes Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_266715_1 1123279.ATUS01000002_gene61 1.69e-28 119.0 COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1J6D8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,PilZ,Response_reg k59_71097_1 997353.HMPREF9144_1927 6.25e-12 62.8 COG0197@1|root,COG0197@2|Bacteria,4NM87@976|Bacteroidetes,2FRZE@200643|Bacteroidia 976|Bacteroidetes J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_71097_3 1509403.GW12_21400 1.82e-13 66.6 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,3NNW9@468|Moraxellaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_692201_1 1167006.UWK_00048 1.13e-75 249.0 COG0305@1|root,COG0305@2|Bacteria 2|Bacteria L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314,ko:K02316,ko:K17680 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03029,ko03032 - - - DnaB_C,Toprim_2,Toprim_N,zf-CHC2 k59_3705_2 749222.Nitsa_0342 2.79e-21 93.2 COG3209@1|root,COG3209@2|Bacteria,1R0C4@1224|Proteobacteria,43CUG@68525|delta/epsilon subdivisions,2YSH0@29547|Epsilonproteobacteria 68525|delta/epsilon subdivisions M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - - k59_724690_1 243265.plu2553 1.76e-26 112.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria 1236|Gammaproteobacteria OU Signal peptide peptidase sppA GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_986258_1 886293.Sinac_3054 4.69e-09 59.3 COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,2IXWV@203682|Planctomycetes 203682|Planctomycetes CO PFAM NHL repeat - - - - - - - - - - - - NHL,Thioredoxin_8 k59_430009_1 572544.Ilyop_1394 1.25e-05 46.2 COG4149@1|root,COG4149@2|Bacteria,378XY@32066|Fusobacteria 32066|Fusobacteria P Binding-protein-dependent transport system inner membrane component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_430009_2 572544.Ilyop_1393 9.57e-108 314.0 COG3842@1|root,COG3842@2|Bacteria 2|Bacteria P ATPase activity modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran k59_430009_3 293826.Amet_4338 1.16e-231 651.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36DK7@31979|Clostridiaceae 186801|Clostridia C Belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_430009_4 1125700.HMPREF9195_00919 4.26e-44 160.0 COG1879@1|root,COG1879@2|Bacteria,2J6MC@203691|Spirochaetes 203691|Spirochaetes G COG1879 ABC-type sugar transport system periplasmic component - - - ko:K10439,ko:K10540,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00214,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3 - - Peripla_BP_4 k59_430009_5 572544.Ilyop_0566 1.57e-152 432.0 COG1082@1|root,COG1082@2|Bacteria 2|Bacteria G myo-inosose-2 dehydratase activity - - 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_38008_1 396588.Tgr7_0523 3.85e-12 67.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_38008_2 1049564.TevJSym_as00720 3.14e-55 183.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1J58N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1019179_1 349106.PsycPRwf_1051 2.02e-19 93.2 COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,3NQKB@468|Moraxellaceae 1236|Gammaproteobacteria Q von willebrand factor, type A - - - - - - - - - - - - Big_3_2,Big_3_3,VCBS k59_626795_2 1485544.JQKP01000004_gene508 4.09e-42 152.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,44VGE@713636|Nitrosomonadales 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component oppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_756994_1 1041826.FCOL_06640 3.22e-45 155.0 COG0177@1|root,COG0177@2|Bacteria,4NE7K@976|Bacteroidetes,1HWQK@117743|Flavobacteriia,2NT1F@237|Flavobacterium 976|Bacteroidetes L Protein of unknown function (DUF2400) - - - - - - - - - - - - DUF2400 k59_169892_1 1238184.CM001792_gene3309 9.39e-38 141.0 COG2391@1|root,COG2391@2|Bacteria,1TSNG@1239|Firmicutes,4HCH9@91061|Bacilli,23INB@182709|Oceanobacillus 91061|Bacilli S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_724696_1 926561.KB900618_gene312 8.95e-184 541.0 COG1033@1|root,COG1033@2|Bacteria 2|Bacteria S growth of symbiont in host cell - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL k59_593752_1 1168034.FH5T_03220 5.52e-47 166.0 COG1404@1|root,COG1404@2|Bacteria,4NEIJ@976|Bacteroidetes,2FNT5@200643|Bacteroidia 976|Bacteroidetes O Belongs to the peptidase S8 family aprN - - - - - - - - - - - Peptidase_S8 k59_1019187_1 1121413.JMKT01000005_gene1000 3.04e-70 220.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NG2@68525|delta/epsilon subdivisions,2WK33@28221|Deltaproteobacteria,2MGH2@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_1019187_2 177437.HRM2_39510 8.63e-15 75.5 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42SM4@68525|delta/epsilon subdivisions,2WPVD@28221|Deltaproteobacteria,2MNUX@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_561872_2 395494.Galf_2867 7.48e-38 139.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,44VMC@713636|Nitrosomonadales 28216|Betaproteobacteria S Polyphosphate kinase 2 (PPK2) pap - - - - - - - - - - - PPK2 k59_137151_1 1121456.ATVA01000005_gene2984 5.07e-49 174.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42NNT@68525|delta/epsilon subdivisions,2WJDP@28221|Deltaproteobacteria,2M8A1@213115|Desulfovibrionales 28221|Deltaproteobacteria NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,DUF3365,HAMP,MCPsignal,dCache_1 k59_593754_1 765913.ThidrDRAFT_1057 9.4e-109 324.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1WXRI@135613|Chromatiales 135613|Chromatiales E Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_921543_1 247490.KSU1_C1634 4.98e-100 309.0 COG0021@1|root,COG0021@2|Bacteria,2IXIA@203682|Planctomycetes 203682|Planctomycetes G Belongs to the transketolase family - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_496316_1 546267.NEIPOLOT_00125 4.25e-05 48.1 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,2KPNM@206351|Neisseriales 206351|Neisseriales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_496316_2 580332.Slit_2531 6.4e-59 187.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,44WFD@713636|Nitrosomonadales 28216|Betaproteobacteria K PFAM ferric-uptake regulator fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_496316_3 1120999.JONM01000002_gene922 7.08e-08 53.9 COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,2VRC6@28216|Betaproteobacteria,2KRPT@206351|Neisseriales 206351|Neisseriales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamE - - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA k59_464085_1 1293047.CBMA010000006_gene141 5.26e-23 100.0 COG3243@1|root,arCOG06234@1|root,arCOG06234@2157|Archaea,arCOG06344@2157|Archaea,2XSZS@28890|Euryarchaeota,23SX8@183963|Halobacteria 183963|Halobacteria I poly(R)-hydroxyalkanoic acid synthase subunit PhaC phaC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,HHH_5 k59_38015_1 1042156.CXIVA_24420 1.14e-79 244.0 COG0602@1|root,COG0602@2|Bacteria,1TQ58@1239|Firmicutes,2499R@186801|Clostridia,36HKB@31979|Clostridiaceae 186801|Clostridia H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14,Radical_SAM k59_38015_2 536232.CLM_1797 1.03e-98 291.0 COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,36DD1@31979|Clostridiaceae 186801|Clostridia F GTP cyclohydrolase folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_38015_3 272562.CA_C3627 1.96e-144 409.0 COG0603@1|root,COG0603@2|Bacteria,1TP4Z@1239|Firmicutes,2497A@186801|Clostridia,36DMD@31979|Clostridiaceae 186801|Clostridia F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_201694_1 991905.SL003B_1781 3.06e-98 298.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2TRI7@28211|Alphaproteobacteria,4BPBK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Circularly permuted ATP-grasp type 2 MA20_32420 - - - - - - - - - - - CP_ATPgrasp_2 k59_823143_1 1417296.U879_08090 3.04e-70 217.0 COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,2U3QM@28211|Alphaproteobacteria 28211|Alphaproteobacteria C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4_9 k59_823143_2 582899.Hden_0692 1.48e-86 266.0 arCOG05916@1|root,30GTU@2|Bacteria,1RDX8@1224|Proteobacteria,2U853@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_823143_3 582899.Hden_0691 1.08e-07 53.1 COG1148@1|root,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria 28211|Alphaproteobacteria C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored,Pyr_redox_2 k59_430040_1 1410668.JNKC01000001_gene1766 2.08e-86 262.0 COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,24CFW@186801|Clostridia,36VPS@31979|Clostridiaceae 186801|Clostridia E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_430040_2 879310.HMPREF9162_2062 1.74e-06 50.1 COG2379@1|root,COG2379@2|Bacteria,1TSQH@1239|Firmicutes,4H6MM@909932|Negativicutes 909932|Negativicutes G MOFRL family ttuD - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_430041_1 1123267.JONN01000001_gene2092 5.86e-10 58.5 2B276@1|root,31UQJ@2|Bacteria,1QSK5@1224|Proteobacteria,2V1G7@28211|Alphaproteobacteria,2KBI1@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_430041_2 693986.MOC_3122 1.45e-37 135.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2TQY2@28211|Alphaproteobacteria,1JSKV@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_986307_1 1165841.SULAR_03777 2.54e-80 258.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,42N8E@68525|delta/epsilon subdivisions,2YNF0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_626833_1 1122179.KB890469_gene602 1.51e-50 184.0 COG3119@1|root,COG3119@2|Bacteria,4NFGI@976|Bacteroidetes,1IQA2@117747|Sphingobacteriia 976|Bacteroidetes P Sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_665940_1 765910.MARPU_14875 4.23e-47 166.0 COG0750@1|root,COG3016@1|root,COG0750@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales 135613|Chromatiales O smart pdz dhr glgf - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_762678_1 314278.NB231_15803 3.25e-45 159.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1WWTH@135613|Chromatiales 135613|Chromatiales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_729614_1 1077285.AGDG01000001_gene3250 2.62e-30 113.0 COG0454@1|root,COG0456@2|Bacteria,4NTRS@976|Bacteroidetes,2FS7C@200643|Bacteroidia,4AQMA@815|Bacteroidaceae 976|Bacteroidetes K acetyltransferase - - - - - - - - - - - - DinB_2 k59_893870_1 1205753.A989_06838 1.54e-57 196.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1X3VI@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the DNA photolyase family phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1024294_1 367737.Abu_1437 2.96e-12 66.2 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42N3E@68525|delta/epsilon subdivisions,2YMM7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM NADH ubiquinone oxidoreductase, 20 Kd subunit hupS - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_1024294_2 1537917.JU82_08455 9.12e-65 213.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42NDE@68525|delta/epsilon subdivisions,2YMNM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Hydrogenase, large subunit hupL - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_762685_1 330214.NIDE3508 4.66e-41 145.0 28N6F@1|root,2ZBBB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_762685_2 1552758.NC00_05875 1.24e-21 86.7 COG2002@1|root,COG2002@2|Bacteria,1QVJI@1224|Proteobacteria,1SEBW@1236|Gammaproteobacteria,1X7N3@135614|Xanthomonadales 135614|Xanthomonadales K SpoVT / AbrB like domain - - - - - - - - - - - - MazE_antitoxin k59_762685_3 196490.AUEZ01000013_gene4677 4.67e-26 99.8 COG3654@1|root,COG3654@2|Bacteria,1N1FW@1224|Proteobacteria,2U8GF@28211|Alphaproteobacteria,3JYGY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Fic/DOC family doc - - ko:K07341 - - - - ko00000,ko02048 - - - Fic k59_632910_1 443254.Marpi_1309 1.43e-23 90.5 COG1278@1|root,COG1278@2|Bacteria,2GDFN@200918|Thermotogae 200918|Thermotogae K PFAM Cold-shock protein, DNA-binding - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_632910_2 572544.Ilyop_1201 7.49e-32 125.0 COG0248@1|root,COG0337@1|root,COG0248@2|Bacteria,COG0337@2|Bacteria,378GB@32066|Fusobacteria 32066|Fusobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 3.6.1.11,3.6.1.40,4.2.3.4 ko:K01524,ko:K01735 ko00230,ko00400,ko01100,ko01110,ko01130,ko01230,map00230,map00400,map01100,map01110,map01130,map01230 M00022 R03083,R03409 RC00002,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,Ppx-GppA k59_403347_1 631362.Thi970DRAFT_00111 2.36e-66 214.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1WWQN@135613|Chromatiales 135613|Chromatiales H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_1024299_1 471853.Bcav_2550 1.57e-114 360.0 COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria 201174|Actinobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_697798_1 1249480.B649_09700 1.39e-92 290.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2YNUN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit - - - ko:K14086 - - - - ko00000 - - - Proton_antipo_M,Proton_antipo_N k59_600285_1 1537917.JU82_07115 2.47e-88 284.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,43BQI@68525|delta/epsilon subdivisions,2YRHF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K17050 - - - - ko00000,ko02000 5.A.3.8 - - Molybdopterin,Molydop_binding k59_469156_1 1122951.ATUE01000005_gene2105 1.23e-22 101.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,3NK4V@468|Moraxellaceae 1236|Gammaproteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_208092_1 572544.Ilyop_0382 7.6e-28 116.0 COG0845@1|root,COG0845@2|Bacteria,378RU@32066|Fusobacteria 32066|Fusobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_3 k59_632918_1 981085.XP_010109403.1 2.4e-34 117.0 2D40V@1|root,2STG3@2759|Eukaryota,381GS@33090|Viridiplantae,3GMA3@35493|Streptophyta,4JUQW@91835|fabids 35493|Streptophyta - - - - - - - - - - - - - - - k59_567621_1 1267534.KB906757_gene1145 7.87e-68 221.0 COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia 204432|Acidobacteriia T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_77137_1 1165841.SULAR_05548 3.65e-101 295.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,42MQB@68525|delta/epsilon subdivisions,2YM8X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_77137_2 1165841.SULAR_05558 2.49e-56 187.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2YMZ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M N-acetylmuramoyl-L-alanine amidase amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_371378_1 1168034.FH5T_14625 2.43e-117 346.0 COG2115@1|root,COG2115@2|Bacteria,4NEBQ@976|Bacteroidetes,2FN9P@200643|Bacteroidia 976|Bacteroidetes G Xylose isomerase xylA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_339513_2 1123377.AUIV01000007_gene1328 3.51e-42 153.0 COG0475@1|root,COG0475@2|Bacteria,1RA3J@1224|Proteobacteria,1RWKQ@1236|Gammaproteobacteria,1X47M@135614|Xanthomonadales 135614|Xanthomonadales P Na h exchange protein - - - - - - - - - - - - Na_H_Exchanger k59_632923_1 944547.ABLL_0892 2.4e-09 63.9 COG1196@1|root,COG1196@2|Bacteria,1QV9R@1224|Proteobacteria 1224|Proteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_927384_1 585543.HMPREF0969_02994 1.52e-96 309.0 COG2605@1|root,COG2605@2|Bacteria,4NHF2@976|Bacteroidetes,2FMWG@200643|Bacteroidia,4AP97@815|Bacteroidaceae 976|Bacteroidetes S GHMP kinase, N-terminal domain protein fkp - - - - - - - - - - - Fucokinase,GHMP_kinases_C,GHMP_kinases_N k59_175589_1 1168034.FH5T_02755 7.76e-114 343.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,4NF25@976|Bacteroidetes,2FSAD@200643|Bacteroidia 976|Bacteroidetes I Phosphate acyltransferases - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_7274_1 765914.ThisiDRAFT_2357 4.62e-28 105.0 COG4783@1|root,COG4783@2|Bacteria,1QYTN@1224|Proteobacteria,1T3U7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_7274_2 1122185.N792_05230 2.95e-13 69.3 COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1X3S5@135614|Xanthomonadales 135614|Xanthomonadales J Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA rlmL GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.173,2.1.1.264 ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_535423_1 572544.Ilyop_1086 1.6e-99 341.0 COG1196@1|root,COG1196@2|Bacteria,37848@32066|Fusobacteria 32066|Fusobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_729638_1 326298.Suden_1255 1.82e-127 385.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2YMXA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C molybdopterin oxidoreductase - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_535426_1 991.IW20_23220 9.87e-37 129.0 COG2050@1|root,COG2050@2|Bacteria,4NNYG@976|Bacteroidetes,1I2BT@117743|Flavobacteriia,2NVWV@237|Flavobacterium 976|Bacteroidetes Q thioesterase ydiI - 3.1.2.28 ko:K19222 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07262 RC00004,RC00174 ko00000,ko00001,ko00002,ko01000 - - - 4HBT,Hydrolase_3 k59_175603_1 292459.STH2685 6.03e-84 265.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia 186801|Clostridia EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_208124_1 90814.KL370891_gene1593 8.36e-69 214.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,4615Z@72273|Thiotrichales 72273|Thiotrichales S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_7281_1 387093.SUN_1187 3.2e-85 272.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42N29@68525|delta/epsilon subdivisions,2YMFM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA helicase rep - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_339535_1 1123371.ATXH01000007_gene541 6.2e-34 130.0 COG0119@1|root,COG0119@2|Bacteria,2GHCY@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Cache domain - - - - - - - - - - - - HMGL-like,dCache_1 k59_339535_2 1123236.KB899376_gene780 5.14e-13 70.5 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,466W8@72275|Alteromonadaceae 1236|Gammaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_697834_1 1713.JOFV01000015_gene1765 6.26e-100 316.0 COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4F0M6@85016|Cellulomonadaceae 201174|Actinobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_860847_1 472759.Nhal_0092 7.9e-69 233.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_435575_1 1392488.JHZY01000002_gene1034 8.2e-36 133.0 COG2826@1|root,COG2826@2|Bacteria,4NJ3V@976|Bacteroidetes,1I1RU@117743|Flavobacteriia 976|Bacteroidetes L Pfam Integrase core domain - - - - - - - - - - - - HTH_38,rve k59_600331_1 926569.ANT_19030 1.51e-09 57.4 COG2220@1|root,COG2220@2|Bacteria,2G6IQ@200795|Chloroflexi 200795|Chloroflexi S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_1024343_1 1121028.ARQE01000010_gene1066 1e-87 268.0 COG2951@1|root,COG2951@2|Bacteria,1MVY0@1224|Proteobacteria,2TTVI@28211|Alphaproteobacteria,2PKWX@255475|Aurantimonadaceae 28211|Alphaproteobacteria M Transglycosylase SLT domain MA20_41385 - - - - - - - - - - - SLT_2 k59_7287_1 1123400.KB904747_gene542 9.18e-83 258.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,4601Y@72273|Thiotrichales 72273|Thiotrichales F Belongs to the GARS family purD - 6.3.2.6,6.3.4.13 ko:K01945,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N,SAICAR_synt k59_371412_1 1366050.N234_37045 2.41e-28 119.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc k59_77178_1 1123073.KB899241_gene1747 6.25e-17 77.4 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1XB0U@135614|Xanthomonadales 135614|Xanthomonadales I CDP-alcohol phosphatidyltransferase - - - - - - - - - - - - CDP-OH_P_transf k59_927418_1 272942.RCAP_rcc03100 9.78e-100 313.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,1FB00@1060|Rhodobacter 28211|Alphaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_959051_1 1537917.JU82_05700 5.91e-204 569.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,42MFN@68525|delta/epsilon subdivisions,2YNDN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_959051_2 1355374.JARU01000015_gene1050 2.69e-151 432.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,42MGE@68525|delta/epsilon subdivisions,2YNH0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_959051_3 620914.JH621285_gene1556 1.51e-05 46.2 COG1898@1|root,COG1898@2|Bacteria,4NNKW@976|Bacteroidetes,1I20V@117743|Flavobacteriia,2YIHX@290174|Aquimarina 976|Bacteroidetes M dTDP-4-dehydrorhamnose 3,5-epimerase rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_109981_1 292459.STH1095 2.63e-31 126.0 COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia 186801|Clostridia P Potassium uptake protein ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1024352_1 314278.NB231_11339 2.15e-102 310.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1WWPY@135613|Chromatiales 135613|Chromatiales I TIGRFAM acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_992557_2 138119.DSY4387 3.77e-52 176.0 COG1296@1|root,COG1296@2|Bacteria,1TP8P@1239|Firmicutes,248NN@186801|Clostridia,262B1@186807|Peptococcaceae 186801|Clostridia E PFAM AzlC - - - - - - - - - - - - AzlC k59_143373_1 1122985.HMPREF1991_02253 2.64e-20 87.4 COG5164@1|root,COG5164@2|Bacteria 2|Bacteria K cell wall organization - - - - - - - - - - - - Collagen k59_698438_1 1121403.AUCV01000028_gene2424 9.83e-72 238.0 COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42MUS@68525|delta/epsilon subdivisions,2WKK4@28221|Deltaproteobacteria,2MP4C@213118|Desulfobacterales 28221|Deltaproteobacteria S homolog of phage Mu protein gp47 - - - - - - - - - - - - - k59_793848_1 1408473.JHXO01000002_gene3953 2.33e-87 285.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FM3B@200643|Bacteroidia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_763435_1 1198232.CYCME_0985 1.61e-126 390.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,45ZT7@72273|Thiotrichales 72273|Thiotrichales L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_240706_1 326423.RBAM_017010 1.85e-40 153.0 COG1020@1|root,COG1028@1|root,COG3321@1|root,COG4221@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HTBC@91061|Bacilli,1ZS7J@1386|Bacillus 91061|Bacilli IQ polyketide synthase - - - ko:K13611,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_928030_1 1499683.CCFF01000014_gene3602 2e-172 488.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,36E13@31979|Clostridiaceae 186801|Clostridia CH D-isomer specific 2-hydroxyacid dehydrogenase hprA - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_928030_2 1499683.CCFF01000014_gene3604 2.58e-54 179.0 COG1082@1|root,COG1082@2|Bacteria,1TRGF@1239|Firmicutes,248GM@186801|Clostridia,36EH7@31979|Clostridiaceae 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_829184_2 765914.ThisiDRAFT_1432 1.18e-27 113.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_763436_1 1168034.FH5T_12760 1.01e-88 275.0 COG0373@1|root,COG0373@2|Bacteria,4NFTY@976|Bacteroidetes,2FT24@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_110501_1 616991.JPOO01000001_gene2838 1.38e-13 70.5 COG1073@1|root,COG2755@1|root,COG1073@2|Bacteria,COG2755@2|Bacteria,4NG53@976|Bacteroidetes,1I165@117743|Flavobacteriia,23H3Z@178469|Arenibacter 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2,Peptidase_S9 k59_110501_2 1168034.FH5T_17210 5.67e-52 181.0 COG1629@1|root,COG4771@2|Bacteria,4PM07@976|Bacteroidetes,2FYI1@200643|Bacteroidia 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_698445_1 472759.Nhal_1845 1.07e-74 250.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM k59_730234_1 457396.CSBG_03562 3.21e-87 258.0 COG1943@1|root,COG1943@2|Bacteria,1V1CM@1239|Firmicutes,24BK2@186801|Clostridia,36HT3@31979|Clostridiaceae 186801|Clostridia L Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_272241_1 452637.Oter_0822 2.12e-08 62.0 COG0642@1|root,COG3279@1|root,COG2205@2|Bacteria,COG3279@2|Bacteria,46TGZ@74201|Verrucomicrobia 74201|Verrucomicrobia T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_240713_2 572544.Ilyop_1368 1.89e-68 212.0 COG2834@1|root,COG2834@2|Bacteria,37ASM@32066|Fusobacteria 32066|Fusobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - - k59_436190_1 1123518.ARWI01000001_gene2235 4.47e-06 52.0 COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,1SE1C@1236|Gammaproteobacteria,4636Z@72273|Thiotrichales 72273|Thiotrichales M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_861489_1 1262449.CP6013_2696 5.54e-07 52.0 COG0640@1|root,COG0640@2|Bacteria,1V9KK@1239|Firmicutes,24NXW@186801|Clostridia,36JM8@31979|Clostridiaceae 186801|Clostridia K regulatory protein, arsR - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 k59_861489_2 1123009.AUID01000011_gene2214 2.33e-61 192.0 COG0394@1|root,COG0394@2|Bacteria,1V3JW@1239|Firmicutes,24HBX@186801|Clostridia,26BHM@186813|unclassified Clostridiales 186801|Clostridia T Low molecular weight phosphatase family arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_272245_1 1238182.C882_2433 2.82e-85 268.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TTPD@28211|Alphaproteobacteria,2JQ42@204441|Rhodospirillales 204441|Rhodospirillales E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_861493_1 709032.Sulku_1006 2.68e-89 273.0 COG0667@1|root,COG0667@2|Bacteria,1RK6Z@1224|Proteobacteria,42QDH@68525|delta/epsilon subdivisions,2YNCD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_698466_1 1236542.BALM01000006_gene3285 5.68e-21 97.1 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,2QAKB@267890|Shewanellaceae 1236|Gammaproteobacteria H TonB-dependent receptor - - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec k59_272248_1 1273103.NM10_00919 0.00027 47.0 2DR0D@1|root,339ND@2|Bacteria,1VMIS@1239|Firmicutes 1239|Firmicutes S Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_793868_1 1049564.TevJSym_bo00010 7.49e-38 136.0 2E7Q4@1|root,3325M@2|Bacteria,1NX94@1224|Proteobacteria,1SQ8F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_77630_1 2340.JV46_26220 1.89e-222 622.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1J4U5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN746.PP_0436 S4,tRNA-synt_1b k59_77630_3 1049564.TevJSym_as00020 1.28e-159 469.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1J4JE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_77630_4 1283300.ATXB01000001_gene1144 4.09e-125 372.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1XE37@135618|Methylococcales 135618|Methylococcales H Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_77630_5 59538.XP_005976059.1 3.16e-49 165.0 COG0103@1|root,COG0316@1|root,KOG1119@2759|Eukaryota,KOG1697@2759|Eukaryota 2759|Eukaryota J structural constituent of ribosome rps9 GO:0000312,GO:0000313,GO:0000314,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005840,GO:0006082,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009102,GO:0009108,GO:0009110,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009547,GO:0009570,GO:0009941,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016053,GO:0016070,GO:0016072,GO:0016226,GO:0017144,GO:0018130,GO:0019538,GO:0019752,GO:0022607,GO:0022613,GO:0030490,GO:0031163,GO:0031967,GO:0031974,GO:0031975,GO:0032787,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0042364,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0044572,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0072330,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996,ko:K15199,ko:K22063,ko:K22072 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03021,ko03029 - - - Fe-S_biosyn,Ribosomal_S9 k59_77630_6 225937.HP15_354 2.99e-35 127.0 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,46885@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG1664 Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_702821_1 631362.Thi970DRAFT_04513 3.55e-142 448.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales 135613|Chromatiales L TIGRFAM ATP-dependent helicase HrpA - - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_997425_1 443144.GM21_2619 9.25e-49 176.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,43S4S@69541|Desulfuromonadales 28221|Deltaproteobacteria T Signal transducing histidine kinase homodimeric cheA34H - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_964177_1 177437.HRM2_28720 5.55e-96 298.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2MHMH@213118|Desulfobacterales 28221|Deltaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA - - 6.2.1.1,6.2.1.17 ko:K01895,ko:K01908 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_440440_1 187272.Mlg_1286 4.52e-135 410.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1X01G@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_508083_1 1118235.CAJH01000022_gene1338 1.98e-40 146.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1X3KZ@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_508083_2 357808.RoseRS_1960 4.72e-58 188.0 COG0066@1|root,COG0066@2|Bacteria,2G6JE@200795|Chloroflexi,3767H@32061|Chloroflexia 32061|Chloroflexia E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_508083_3 313596.RB2501_15804 6.65e-08 53.5 COG0473@1|root,COG0473@2|Bacteria,4NEBE@976|Bacteroidetes,1HXG5@117743|Flavobacteriia 976|Bacteroidetes CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_276118_2 913325.N799_00120 2.9e-35 128.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1X3B0@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_898853_1 1120963.KB894496_gene2642 2.21e-32 123.0 COG2111@1|root,COG2111@2|Bacteria,1QVK4@1224|Proteobacteria,1T54T@1236|Gammaproteobacteria,2Q4I9@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P Domain related to MnhB subunit of Na+/H+ antiporter - - - - - - - - - - - - MnhB k59_898853_2 42256.RradSPS_0982 1.31e-21 88.2 COG1006@1|root,COG1006@2|Bacteria,2GSHQ@201174|Actinobacteria 201174|Actinobacteria P NADH-ubiquinone/plastoquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_605470_1 572544.Ilyop_1085 2.25e-88 279.0 COG3044@1|root,COG3044@2|Bacteria,3784Y@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - ABC_ATPase k59_964204_1 158822.LH89_21920 5.69e-64 204.0 COG0010@1|root,COG0010@2|Bacteria,1MWZY@1224|Proteobacteria,1RS4R@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the arginase family - - 3.5.3.1 ko:K01476 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00134 R00551 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_81553_1 33898.JRHJ01000100_gene6193 8.4e-08 57.8 COG1595@1|root,COG1595@2|Bacteria,2GNZA@201174|Actinobacteria 201174|Actinobacteria K Right handed beta helix region - - - - - - - - - - - - Beta_helix,Chondroitinas_B,DUF1565 k59_865603_2 385682.AFSL01000023_gene2128 4.55e-35 128.0 28PR3@1|root,2ZCD0@2|Bacteria,4NMAF@976|Bacteroidetes,2FTY0@200643|Bacteroidia,3XK1I@558415|Marinilabiliaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_964214_1 398525.KB900701_gene6945 2.26e-49 171.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2TQX6@28211|Alphaproteobacteria,3JTAC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G FGGY family of carbohydrate kinases, C-terminal domain - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_670970_1 566466.NOR53_2388 3.35e-18 88.2 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J7JI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S some members contain a von Willebrand factor type A (vWA - - - - - - - - - - - - DUF58 k59_932108_1 381666.PHG101 7.14e-85 262.0 COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,2VKAK@28216|Betaproteobacteria,1K5RX@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3 k59_670975_2 1463820.JOGW01000015_gene2413 1.76e-23 98.6 COG1794@1|root,COG1794@2|Bacteria,2H7J9@201174|Actinobacteria 201174|Actinobacteria M aspartate racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_572327_1 1408473.JHXO01000009_gene3445 6.98e-29 107.0 COG3118@1|root,COG3118@2|Bacteria,4NQNX@976|Bacteroidetes,2FUHX@200643|Bacteroidia 976|Bacteroidetes O Thioredoxin trxA2 - - - - - - - - - - - Thioredoxin k59_734312_1 563040.Saut_1508 7.65e-137 395.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,42KZY@68525|delta/epsilon subdivisions,2YMQF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_47117_1 344747.PM8797T_07462 2.15e-90 279.0 COG0439@1|root,COG0439@2|Bacteria,2IWZV@203682|Planctomycetes 203682|Planctomycetes I Biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_797298_1 349106.PsycPRwf_1087 2.83e-32 134.0 COG2304@1|root,COG2373@1|root,COG2911@1|root,COG2931@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,3NKB9@468|Moraxellaceae 1236|Gammaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - ko:K11005 - - - - ko00000,ko02000,ko02042 1.C.11 - - Big_3_2,Cadherin_3,Calx-beta,HCBP_related,He_PIG,HemolysinCabind,OmpA_membrane,RTX,RTX_C,VWA_2,fn3 k59_797298_2 93220.LV28_20840 1.41e-19 92.4 COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,1JZN0@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the ompA family ompA - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA k59_797298_4 749222.Nitsa_R0015 2.04e-116 347.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,42N7I@68525|delta/epsilon subdivisions,2YMDW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase k59_572332_1 59538.XP_005973383.1 4.65e-112 334.0 COG0719@1|root,2QRGW@2759|Eukaryota,39YBY@33154|Opisthokonta,3BMZB@33208|Metazoa,3DFBD@33213|Bilateria 33208|Metazoa O Uncharacterized protein family (UPF0051) - - - - - - - - - - - - UPF0051 k59_47803_1 1484460.JSWG01000009_gene163 1.27e-106 319.0 COG0126@1|root,COG0126@2|Bacteria,4NFW2@976|Bacteroidetes,1HX73@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_541053_1 84531.JMTZ01000053_gene1552 1.29e-73 236.0 COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,1RN2Q@1236|Gammaproteobacteria,1X3YT@135614|Xanthomonadales 135614|Xanthomonadales S transcriptional regulator - - 1.14.11.47 ko:K18850 - - - - ko00000,ko01000,ko03009 - - - Cupin_4 k59_441228_1 311403.Arad_1433 4.99e-100 297.0 COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,2TQRG@28211|Alphaproteobacteria,4BCDW@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ reductase - - - - - - - - - - - - adh_short_C2 k59_638619_1 1249480.B649_01445 5.06e-34 135.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2YMJS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,NIT,Response_reg k59_606195_1 1196028.ALEF01000019_gene2266 7.59e-32 121.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HD2I@91061|Bacilli,4C66P@84406|Virgibacillus 91061|Bacilli IQ short chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_1029661_1 326298.Suden_0150 4.99e-31 114.0 2AIVI@1|root,319CU@2|Bacteria,1Q2CK@1224|Proteobacteria,42UBC@68525|delta/epsilon subdivisions,2YPZT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_148928_1 287.DR97_5907 2.84e-105 328.0 COG2010@1|root,COG2010@2|Bacteria,1MVYK@1224|Proteobacteria,1RQH2@1236|Gammaproteobacteria,1YEVD@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_376772_1 261292.Nit79A3_2842 2.64e-74 237.0 COG3677@1|root,COG3677@2|Bacteria,1R999@1224|Proteobacteria,2W6FU@28216|Betaproteobacteria,3744A@32003|Nitrosomonadales 28216|Betaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595 k59_345287_2 329726.AM1_4440 2.99e-21 89.4 COG3070@1|root,COG3070@2|Bacteria,1G9PX@1117|Cyanobacteria 1117|Cyanobacteria K TfoX N-terminal domain - - - ko:K07343 - - - - ko00000 - - - TfoX_N k59_345287_3 404589.Anae109_4500 5.32e-30 114.0 COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2YVIX@29|Myxococcales 28221|Deltaproteobacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_508873_1 1401065.HMPREF2130_02305 1.02e-68 223.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,3T30M@506|Alcaligenaceae 28216|Betaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_11872_1 697284.ERIC2_c36870 9.58e-39 136.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,4HAVS@91061|Bacilli,26R6G@186822|Paenibacillaceae 91061|Bacilli J Belongs to the pseudouridine synthase RsuA family rluF - 5.4.99.21 ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_11872_2 595537.Varpa_1741 2.23e-33 127.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,4A9T8@80864|Comamonadaceae 28216|Betaproteobacteria C TIGRFAM methylmalonate-semialdehyde dehydrogenase - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_998178_1 1537917.JU82_01520 2.06e-141 409.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,42M5T@68525|delta/epsilon subdivisions,2YNN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cofactor biosynthesis protein NifE - - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_541054_1 1322246.BN4_12315 0.000286 48.9 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HTH_31,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1 k59_214040_1 326298.Suden_1933 3.67e-47 159.0 COG4121@1|root,COG4121@2|Bacteria,1Q8T8@1224|Proteobacteria,42RAP@68525|delta/epsilon subdivisions,2YP3B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_30 k59_541062_1 439235.Dalk_1266 1.7e-56 187.0 COG0755@1|root,COG0755@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2WIKV@28221|Deltaproteobacteria,2MHQ1@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_834123_1 283942.IL0968 5.29e-91 291.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,2QFJG@267893|Idiomarinaceae 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_345300_1 335543.Sfum_0186 3.08e-51 176.0 COG0463@1|root,COG0463@2|Bacteria,1R547@1224|Proteobacteria,42PDC@68525|delta/epsilon subdivisions,2WKYW@28221|Deltaproteobacteria,2MR35@213462|Syntrophobacterales 28221|Deltaproteobacteria M glycosyl transferase family 2 - - 2.4.1.268 ko:K21349 - - - - ko00000,ko01000 - GT81 - Glycos_transf_2 k59_899646_1 518766.Rmar_0342 7.24e-131 391.0 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1FJVJ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrd - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_376784_1 929558.SMGD1_0351 1.11e-56 196.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42N29@68525|delta/epsilon subdivisions,2YMFM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA helicase rep - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_376791_1 1577887.JSYG01000034_gene3377 1.38e-06 50.4 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,2JBN9@204037|Dickeya 1236|Gammaproteobacteria M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins mreD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_376791_2 1469245.JFBG01000040_gene1716 8.98e-25 105.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_735145_1 1168034.FH5T_04485 6.46e-44 155.0 COG0659@1|root,COG0659@2|Bacteria,4NF1C@976|Bacteroidetes 976|Bacteroidetes P Sulfate permease ychM - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_899649_1 1182590.BN5_00241 5.48e-54 182.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RS3I@1236|Gammaproteobacteria,1YFBW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion yhiI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_474182_2 314287.GB2207_06528 3.51e-37 137.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J53P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ammonium Transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_310427_1 746697.Aeqsu_2524 5.03e-44 157.0 COG1212@1|root,COG1454@1|root,COG1212@2|Bacteria,COG1454@2|Bacteria,4NG4B@976|Bacteroidetes,1HXV5@117743|Flavobacteriia 976|Bacteroidetes M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 1.1.3.48,2.7.7.38 ko:K00979,ko:K19714 ko00540,ko01100,map00540,map01100 M00063 R03351,R11394,R11396 RC00152,RC00910,RC03427 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_310427_2 1121896.JMLU01000028_gene2798 1.41e-35 126.0 COG0204@1|root,COG0204@2|Bacteria,4NNG7@976|Bacteroidetes,1I28N@117743|Flavobacteriia,2NUUF@237|Flavobacterium 976|Bacteroidetes I Acyltransferase - - - - - - - - - - - - Acyltransferase k59_115339_1 273068.TTE1651 3.9e-05 52.0 COG0768@1|root,COG2815@1|root,COG0768@2|Bacteria,COG2815@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,42FD0@68295|Thermoanaerobacterales 186801|Clostridia M TIGRFAM stage V sporulation protein D spoVD - 3.4.16.4 ko:K03587,ko:K08384 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_638651_1 713586.KB900536_gene2658 9.94e-74 233.0 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1WZXR@135613|Chromatiales 135613|Chromatiales L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_671845_1 1168034.FH5T_06695 1.17e-111 332.0 COG0750@1|root,COG0750@2|Bacteria,4NEAR@976|Bacteroidetes,2FM5E@200643|Bacteroidia 976|Bacteroidetes M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_866347_1 1033738.CAEP01000041_gene766 1.59e-82 254.0 COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,4HBQC@91061|Bacilli,26D5V@186818|Planococcaceae 91061|Bacilli H Belongs to the ALAD family hemB GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_932892_1 1123253.AUBD01000004_gene1062 2.59e-47 166.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1X5V3@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_115356_1 709032.Sulku_2255 1.74e-78 241.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,42N66@68525|delta/epsilon subdivisions,2YMY7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_115356_2 1121859.KB890744_gene684 1.82e-13 68.9 COG1917@1|root,COG1917@2|Bacteria,4NSE1@976|Bacteroidetes 976|Bacteroidetes S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - AraC_binding,Cupin_2 k59_409039_1 223926.28806779 1.99e-145 413.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1Y2S7@135623|Vibrionales 135623|Vibrionales L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_1029712_1 1301100.HG529244_gene2335 5.03e-37 132.0 COG3153@1|root,COG3153@2|Bacteria,1V3PW@1239|Firmicutes,24ACS@186801|Clostridia,36J99@31979|Clostridiaceae 186801|Clostridia K Acetyltransferase (GNAT) family - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_9 k59_148972_1 1298920.KI911353_gene432 1.22e-09 64.3 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,21ZWC@1506553|Lachnoclostridium 186801|Clostridia E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_115366_1 880073.Calab_0276 2.28e-83 267.0 COG1523@1|root,COG1523@2|Bacteria,2NPQU@2323|unclassified Bacteria 2|Bacteria G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_508920_1 1165841.SULAR_02788 1.58e-82 272.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2YNJ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cznA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_11916_1 935863.AWZR01000013_gene1524 7.99e-07 57.0 COG1404@1|root,COG3291@1|root,COG4935@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4935@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1X484@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the peptidase S8 family - GO:0005575,GO:0005576 - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PKD,PPC,P_proprotein,Peptidase_S8 k59_115369_1 368407.Memar_0352 2.66e-68 236.0 COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2NAA0@224756|Methanomicrobia 224756|Methanomicrobia P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_245730_1 572477.Alvin_1885 4.3e-45 159.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1WW0S@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, delta' - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_965009_1 187272.Mlg_1187 1.05e-72 246.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_768782_1 2340.JV46_17320 6.21e-75 231.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1J5A9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D ATPases involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_310465_1 1380380.JIAX01000011_gene2503 5.54e-54 192.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria 28211|Alphaproteobacteria L double-strand break repair protein AddB addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_541115_1 709032.Sulku_0736 3.88e-31 112.0 2BJZK@1|root,32ECD@2|Bacteria,1QDIV@1224|Proteobacteria,433KD@68525|delta/epsilon subdivisions,2YSRX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_735176_1 666686.B1NLA3E_19555 1.03e-158 477.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,4HAI0@91061|Bacilli,1ZAVE@1386|Bacillus 91061|Bacilli P P-type ATPase copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_310478_1 1001585.MDS_4328 6.71e-59 191.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1YD75@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0422 IGPS k59_82389_1 1408813.AYMG01000038_gene172 8.24e-49 184.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1IX23@117747|Sphingobacteriia 976|Bacteroidetes P CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_345372_1 1232410.KI421414_gene2904 1.36e-52 172.0 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,42TIF@68525|delta/epsilon subdivisions,2WQC4@28221|Deltaproteobacteria,43SR3@69541|Desulfuromonadales 28221|Deltaproteobacteria I CDP-alcohol phosphatidyltransferase pgsA-2 - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_899699_1 749222.Nitsa_1457 1.59e-64 211.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,42N4K@68525|delta/epsilon subdivisions,2YMVY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S HI0933 family - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_474222_1 1249480.B649_08740 8.38e-60 192.0 COG3267@1|root,COG3267@2|Bacteria,1QUIM@1224|Proteobacteria,42NAC@68525|delta/epsilon subdivisions,2YNHY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U ATPase (AAA - - 4.3.3.7 ko:K01714,ko:K12283 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000,ko02044 - - - AAA_22 k59_115394_1 926556.Echvi_3987 3.2e-11 68.9 2C0N3@1|root,2Z8N4@2|Bacteria,4NJ1V@976|Bacteroidetes,47QZC@768503|Cytophagia 976|Bacteroidetes S SusE outer membrane protein - - - ko:K21571 - - - - ko00000 - - - SusE,SusF_SusE k59_115395_1 760568.Desku_1141 4.69e-63 216.0 COG0438@1|root,COG1543@1|root,COG0438@2|Bacteria,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,2498V@186801|Clostridia,261CP@186807|Peptococcaceae 186801|Clostridia M Starch synthase catalytic - - 2.4.1.18 ko:K16149 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000 - GH57 - DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1 k59_612088_1 1049564.TevJSym_ai00340 1.53e-84 273.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1J534@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_677954_2 563040.Saut_2157 1.06e-70 233.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2YN94@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_612089_1 869213.JCM21142_41626 1.08e-68 222.0 COG0569@1|root,COG0569@2|Bacteria,4NE31@976|Bacteroidetes,47NY5@768503|Cytophagia 976|Bacteroidetes P TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_515009_1 990073.ATHU01000003_gene1861 1.13e-119 350.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42M26@68525|delta/epsilon subdivisions,2YMEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S polyphosphate kinase - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_382621_1 1249480.B649_05415 6.27e-80 266.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2YMD8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin por - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_872457_3 1123278.KB893580_gene927 1.52e-06 49.3 COG4636@1|root,COG4636@2|Bacteria,4NSSG@976|Bacteroidetes,47RCY@768503|Cytophagia 976|Bacteroidetes S Putative restriction endonuclease - - - - - - - - - - - - Uma2 k59_741083_1 1122176.KB903587_gene4552 1.78e-22 98.2 COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes,1IWK7@117747|Sphingobacteriia 976|Bacteroidetes S Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_741083_2 1219072.VHA01S_020_00220 5.94e-223 637.0 COG0591@1|root,COG0591@2|Bacteria,1MW6E@1224|Proteobacteria,1RXYK@1236|Gammaproteobacteria,1XSDY@135623|Vibrionales 135623|Vibrionales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_741083_3 1408422.JHYF01000004_gene1559 5.52e-07 50.1 COG3717@1|root,COG3717@2|Bacteria,1TP4X@1239|Firmicutes,24A00@186801|Clostridia,36FCR@31979|Clostridiaceae 186801|Clostridia G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_905808_1 1235457.C404_04260 0.000493 42.0 COG0457@1|root,COG0457@2|Bacteria,1QW4E@1224|Proteobacteria 1224|Proteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2,TPR_8 k59_804129_1 1319815.HMPREF0202_02484 9.7e-26 104.0 COG0436@1|root,COG0436@2|Bacteria,3797Z@32066|Fusobacteria 32066|Fusobacteria E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_804129_2 572544.Ilyop_1123 1.3e-95 296.0 COG5438@1|root,COG5438@2|Bacteria,378GQ@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - YibE_F k59_804129_4 536233.CLO_0172 8.25e-24 99.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,36E9P@31979|Clostridiaceae 186801|Clostridia G Transketolase tktB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_220085_1 1168034.FH5T_11600 5.4e-55 185.0 28TKX@1|root,2ZFUJ@2|Bacteria,4NKCT@976|Bacteroidetes,2G3EV@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_774815_1 472759.Nhal_3855 3.34e-25 95.5 COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1WZR6@135613|Chromatiales 135613|Chromatiales S Zinc-finger domain - - - - - - - - - - - - zf-CHCC k59_774815_2 1385515.N791_06785 4.57e-46 153.0 COG0859@1|root,COG0859@2|Bacteria,1MZGQ@1224|Proteobacteria,1S7TT@1236|Gammaproteobacteria,1X6DP@135614|Xanthomonadales 135614|Xanthomonadales M PFAM glycosyl transferase family 9 - - - - - - - - - - - - - k59_677984_1 388413.ALPR1_11965 3.45e-145 430.0 COG3119@1|root,COG3119@2|Bacteria,4NEBN@976|Bacteroidetes,47TP1@768503|Cytophagia 976|Bacteroidetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_644754_1 321846.PS417_26760 1.52e-47 166.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound yggW GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_804133_2 1123393.KB891316_gene1442 2.99e-22 90.9 COG2920@1|root,COG2920@2|Bacteria,1N6BZ@1224|Proteobacteria,2WCAJ@28216|Betaproteobacteria,1KTBU@119069|Hydrogenophilales 119069|Hydrogenophilales P DsrC like protein - - - - - - - - - - - - DsrC k59_18080_1 768671.ThimaDRAFT_2229 6.46e-103 330.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WX8J@135613|Chromatiales 135613|Chromatiales EI Allophanate hydrolase subunit 1 - - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_282962_1 1537917.JU82_01665 1.04e-141 440.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2YMP9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_872477_1 935567.JAES01000011_gene1140 1.65e-122 384.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1X36U@135614|Xanthomonadales 135614|Xanthomonadales CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_741098_1 859657.RPSI07_3381 6.01e-09 57.8 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2VHCJ@28216|Betaproteobacteria,1JZXE@119060|Burkholderiaceae 28216|Betaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_741098_2 1001585.MDS_4955 2.52e-45 161.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1YCU3@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_447225_1 1121439.dsat_2451 2.14e-36 126.0 2EF0Y@1|root,338U3@2|Bacteria,1NEBW@1224|Proteobacteria,42VND@68525|delta/epsilon subdivisions,2WSBJ@28221|Deltaproteobacteria,2MDEW@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_971099_1 2340.JV46_13570 2.08e-49 169.0 2B5QC@1|root,31YJX@2|Bacteria,1RIBA@1224|Proteobacteria,1SPMT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - MotA_ExbB k59_515041_1 522306.CAP2UW1_0179 4.53e-95 295.0 COG2262@1|root,COG2262@2|Bacteria,1QV04@1224|Proteobacteria,2WGNW@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF3482) - - - - - - - - - - - - DUF3482,MMR_HSR1 k59_678003_1 506534.Rhein_0859 1.16e-32 125.0 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1WVVW@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_938740_2 1249480.B649_08455 7.53e-15 79.0 COG1216@1|root,COG1216@2|Bacteria,1PZHI@1224|Proteobacteria,4333V@68525|delta/epsilon subdivisions 1224|Proteobacteria S Glycosyl transferase, family 2 - - - - - - - - - - - - Sulfotransfer_2 k59_938740_3 649638.Trad_2221 1.39e-19 90.1 COG3774@1|root,COG3774@2|Bacteria 2|Bacteria M pathogenesis MA20_43635 - - - - - - - - - - - Caps_synth k59_1035427_1 439235.Dalk_5084 1.35e-75 245.0 COG2041@1|root,COG2041@2|Bacteria,1NS6T@1224|Proteobacteria,42YA7@68525|delta/epsilon subdivisions,2WTM5@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - - - - - - - - - - - k59_905829_1 1538295.JY96_18885 3.04e-23 103.0 2DV3U@1|root,33TXD@2|Bacteria,1NUW0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_741107_1 247633.GP2143_11232 3.66e-53 181.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1RRMI@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_282967_1 187272.Mlg_1129 7.12e-43 158.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,1RQBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_447234_2 1073999.BN137_1158 5.18e-17 76.3 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,1S6K6@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_678011_1 264732.Moth_0256 1.36e-37 143.0 COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,42ER0@68295|Thermoanaerobacterales 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_840255_1 1165841.SULAR_00280 4.84e-81 256.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42MXQ@68525|delta/epsilon subdivisions,2YM9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0098 PALP,Thr_synth_N k59_251836_2 631362.Thi970DRAFT_01550 2.1e-28 104.0 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1WYU8@135613|Chromatiales 135613|Chromatiales J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_678024_1 272559.BF9343_3945 3.59e-67 223.0 COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,2FNIQ@200643|Bacteroidia,4AKE2@815|Bacteroidaceae 976|Bacteroidetes L COG COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_155094_1 1321815.HMPREF9193_02103 0.000733 43.1 COG0811@1|root,COG0811@2|Bacteria,2J700@203691|Spirochaetes 203691|Spirochaetes U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_155094_2 1049564.TevJSym_al00470 9.05e-42 142.0 COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,1J6HT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0848 Biopolymer transport protein exbD1 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_971125_1 1040989.AWZU01000004_gene7025 3.66e-91 277.0 COG3964@1|root,COG3964@2|Bacteria,1MVC7@1224|Proteobacteria,2TSUD@28211|Alphaproteobacteria,3JSBJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Amidohydrolase family MA20_40145 - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_905848_1 1149133.ppKF707_3876 8.35e-35 128.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria,1YDQY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S PrpF protein prpF GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046459,GO:0071704,GO:0072329,GO:1901575 - ko:K09788 ko00640,map00640 - R11264 RC03405 ko00000,ko00001,ko01000 - - - PrpF k59_905848_2 402626.Rpic_3859 9.59e-239 679.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,1K1NF@119060|Burkholderiaceae 28216|Betaproteobacteria C aconitate hydratase acnD - 4.2.1.117,4.2.1.3 ko:K01681,ko:K20455 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900,R11263 RC00497,RC00498,RC00618,RC01152 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1004301_1 330214.NIDE0473 1.14e-86 266.0 COG4307@1|root,COG4307@2|Bacteria 2|Bacteria T Protein conserved in bacteria - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_53914_1 1056820.KB900642_gene426 1.61e-19 88.2 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,2PN3Q@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria F Amidohydrolase family mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_774869_1 3702.ATCG01010.1 1.81e-133 404.0 COG1007@1|root,KOG4668@2759|Eukaryota,37P90@33090|Viridiplantae,3GBJ3@35493|Streptophyta 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.6.5.3 ko:K05577 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_220141_1 1165096.ARWF01000001_gene1976 9.59e-23 102.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KMDI@206350|Nitrosomonadales 206350|Nitrosomonadales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg k59_1004303_1 1123368.AUIS01000004_gene139 4.1e-32 124.0 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria 1236|Gammaproteobacteria T universal stress protein - - - - - - - - - - - - Usp k59_121610_1 1123368.AUIS01000008_gene2160 3.66e-126 379.0 COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,1RNHS@1236|Gammaproteobacteria,2NCRR@225057|Acidithiobacillales 225057|Acidithiobacillales F ribonucleoside-triphosphate reductase - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,NRDD k59_741123_1 1165841.SULAR_08107 1.09e-69 269.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind k59_774875_1 472759.Nhal_3687 5.59e-80 253.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_741127_1 1168034.FH5T_07995 2.59e-114 335.0 COG0115@1|root,COG0115@2|Bacteria,4NEJY@976|Bacteroidetes,2FMPE@200643|Bacteroidia 976|Bacteroidetes EH branched-chain-amino-acid transaminase ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_54438_1 743719.PaelaDRAFT_5530 7.63e-77 245.0 COG0668@1|root,COG0668@2|Bacteria,1TSHU@1239|Firmicutes,4HBC1@91061|Bacilli,26T2D@186822|Paenibacillaceae 91061|Bacilli M Mechanosensitive ion channel - - - ko:K16053 - - - - ko00000,ko02000 1.A.23.4.5 - - MS_channel k59_54438_2 28444.JODQ01000013_gene2906 5.64e-69 226.0 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4EHMJ@85012|Streptosporangiales 201174|Actinobacteria E TOBE domain - - - ko:K02052,ko:K11084 ko02010,ko02024,map02010,map02024 M00193,M00302 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11,3.A.1.11.5 - - ABC_tran,TOBE_2 k59_775467_1 1122176.KB903557_gene4052 3.55e-29 120.0 COG1452@1|root,COG1934@1|root,COG1452@2|Bacteria,COG1934@2|Bacteria,4NDU3@976|Bacteroidetes,1IP5G@117747|Sphingobacteriia 976|Bacteroidetes M OstA-like protein lptD - - - - - - - - - - - OstA_2 k59_515764_1 1165841.SULAR_07975 1.57e-32 113.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,42TGC@68525|delta/epsilon subdivisions,2YQA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_1036104_1 1278309.KB907107_gene1738 1.42e-06 52.4 COG1334@1|root,COG1334@2|Bacteria 2|Bacteria N flagellar protein FlaG flaG - - ko:K06603 - - - - ko00000,ko02035 - - - FlaG k59_252466_1 926569.ANT_30630 7.25e-42 147.0 COG1606@1|root,COG1606@2|Bacteria,2G6AU@200795|Chloroflexi 200795|Chloroflexi L tRNA processing - - - ko:K06864 - - - - ko00000 - - - Asn_synthase,NAD_synthase k59_447953_1 1168034.FH5T_17080 1.11e-61 202.0 COG4591@1|root,COG4591@2|Bacteria,4NHBR@976|Bacteroidetes,2FSNX@200643|Bacteroidia 976|Bacteroidetes M FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD k59_613000_1 1219045.BV98_000436 2.11e-33 128.0 COG0702@1|root,COG0702@2|Bacteria,1RCCP@1224|Proteobacteria,2TU1D@28211|Alphaproteobacteria,2K0TF@204457|Sphingomonadales 204457|Sphingomonadales GM epimerase - - - - - - - - - - - - NAD_binding_10 k59_54455_1 1205908.AKXW01000084_gene2037 1.04e-27 115.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1XT1S@135623|Vibrionales 135623|Vibrionales I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_252473_1 1380391.JIAS01000012_gene4436 2.02e-43 160.0 COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBR@1224|Proteobacteria,2U1RE@28211|Alphaproteobacteria,2JZB7@204441|Rhodospirillales 204441|Rhodospirillales T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - GAF_2,HATPase_c_2,SpoIIE k59_741617_1 272560.BPSS1445 2.4e-66 221.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,1K2QQ@119060|Burkholderiaceae 28216|Betaproteobacteria I carboxylase accA1 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.3,6.4.1.4 ko:K01965,ko:K01968 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00036,M00373,M00741 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_741617_2 497321.C664_18077 6.74e-07 50.4 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,2KU7S@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_89237_1 1121939.L861_10520 3.4e-25 112.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RMI7@1236|Gammaproteobacteria,1XISC@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K18298,ko:K19586 - M00641,M00767 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.47,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_873006_1 472759.Nhal_2617 3.72e-17 83.2 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1WWJW@135613|Chromatiales 135613|Chromatiales S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_188211_1 1168034.FH5T_00830 3.63e-101 298.0 COG2755@1|root,COG2755@2|Bacteria,4NKE5@976|Bacteroidetes,2G08I@200643|Bacteroidia 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_613020_1 598659.NAMH_1365 8.51e-65 213.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_54468_1 1232437.KL662077_gene1940 2.35e-93 290.0 COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria,2MJ41@213118|Desulfobacterales 28221|Deltaproteobacteria CP Proton-conducting membrane transporter ehrA-2 - - ko:K12137 - - - - ko00000,ko01000 - - - Proton_antipo_M,Proton_antipo_N k59_710352_2 380703.AHA_3255 1.05e-35 133.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1Y427@135624|Aeromonadales 135624|Aeromonadales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1036161_1 1249480.B649_05650 2.74e-36 129.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,42N3R@68525|delta/epsilon subdivisions,2YMWT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Belongs to the flagella basal body rod proteins family flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1036161_2 709032.Sulku_0986 1.45e-98 288.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42R6H@68525|delta/epsilon subdivisions,2YP0H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_11351_1 439235.Dalk_2743 4.89e-12 63.9 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria,2MJSM@213118|Desulfobacterales 28221|Deltaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_540605_1 425104.Ssed_2568 3.75e-104 336.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,2QBA4@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM Aldehyde ferredoxin oxidoreductase ydhV GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0030151,GO:0033719,GO:0043167,GO:0043169,GO:0043546,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0097159,GO:1901363 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_1029210_3 760568.Desku_3569 4.81e-13 74.7 COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,261MW@186807|Peptococcaceae 186801|Clostridia U Membrane protein insertase, YidC Oxa1 family oxaA - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP k59_1029210_4 1246626.BleG1_3993 1.54e-15 77.8 COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,4HHHU@91061|Bacilli,1ZDGU@1386|Bacillus 91061|Bacilli S single-stranded nucleic acid binding R3H jag - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H k59_540622_2 1168034.FH5T_01385 1.48e-123 363.0 COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes,2FNEC@200643|Bacteroidia 976|Bacteroidetes P Psort location CytoplasmicMembrane, score 10.00 amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_703179_1 1168034.FH5T_15000 3.59e-95 288.0 COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,2FNV5@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_181107_1 264732.Moth_0039 4.27e-10 66.2 COG0247@1|root,COG0247@2|Bacteria,1TR46@1239|Firmicutes,24AIF@186801|Clostridia,42GDG@68295|Thermoanaerobacterales 186801|Clostridia C 4Fe-4S dicluster domain glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_47399_1 991905.SL003B_0046 9.45e-88 266.0 COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,4BQ5Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L 6-O-methylguanine DNA methyltransferase, DNA binding domain ada - 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - DNA_binding_1,HTH_18 k59_148519_1 243090.RB8939 9.44e-09 57.4 COG0640@1|root,COG0640@2|Bacteria,2J3B8@203682|Planctomycetes 203682|Planctomycetes K Bacterial regulatory protein, arsR - - - - - - - - - - - - HTH_20 k59_148519_2 926561.KB900618_gene312 7.64e-20 90.1 COG1033@1|root,COG1033@2|Bacteria 2|Bacteria S growth of symbiont in host cell - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL k59_213566_2 1279017.AQYJ01000024_gene1138 3.09e-06 48.5 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,465AY@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_309965_2 1217713.F993_00809 6.63e-34 135.0 2FFQP@1|root,347MZ@2|Bacteria,1P2MY@1224|Proteobacteria,1SR7W@1236|Gammaproteobacteria,3NMCC@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_309965_3 1123034.JMKP01000066_gene2438 1.73e-07 60.8 COG3210@1|root,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,1RNRK@1236|Gammaproteobacteria,3NK7X@468|Moraxellaceae 1236|Gammaproteobacteria U Large exoproteins involved in heme utilization or adhesion - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - DUF637,ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act,PT-VENN,Tox-REase-7 k59_899193_1 546275.FUSPEROL_00061 1.83e-111 350.0 COG0553@1|root,COG0553@2|Bacteria,37926@32066|Fusobacteria 32066|Fusobacteria L domain protein - - - - - - - - - - - - Helicase_C,PLDc_2,SNF2_N k59_47409_1 768671.ThimaDRAFT_2776 5.27e-84 257.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1WXI2@135613|Chromatiales 135613|Chromatiales S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_114898_1 1049564.TevJSym_ag00510 5.85e-83 253.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1J4SR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_440786_1 563040.Saut_0553 1.03e-105 319.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2YN1U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_245190_1 387092.NIS_1125 1.82e-148 430.0 COG2801@1|root,COG2801@2|Bacteria,1MVTI@1224|Proteobacteria,43AP5@68525|delta/epsilon subdivisions,2YS2P@29547|Epsilonproteobacteria 1224|Proteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_28,HTH_32,rve,rve_3 k59_540651_1 1165841.SULAR_05123 1.21e-112 332.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2YMIV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_540651_2 1165841.SULAR_05118 2.09e-15 72.0 COG2862@1|root,COG2862@2|Bacteria,1RFUX@1224|Proteobacteria,42T0B@68525|delta/epsilon subdivisions,2YP5M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane - - - - - - - - - - - - UPF0114 k59_605774_1 1123315.AUIP01000003_gene165 2.79e-22 99.0 COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,4HBP5@91061|Bacilli 91061|Bacilli G belongs to the glycosyl hydrolase 13 family pulA2 - 3.2.1.1,3.2.1.41 ko:K01176,ko:K01200 ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973 - R02108,R02111,R02112,R11262 - ko00000,ko00001,ko01000 - CBM48,GH13 - Alpha-amylase,Big_2,CBM_48,G5,Gram_pos_anchor,PUD,SLH,YSIRK_signal k59_276468_1 1121935.AQXX01000139_gene3078 1.74e-05 47.8 COG2984@1|root,COG2984@2|Bacteria,1PHTD@1224|Proteobacteria,1RRJH@1236|Gammaproteobacteria,1XMRN@135619|Oceanospirillales 135619|Oceanospirillales S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_899207_1 1049564.TevJSym_af00530 1.02e-50 179.0 28K74@1|root,2Z9VA@2|Bacteria,1R8MQ@1224|Proteobacteria,1SKKZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_932425_1 879212.DespoDRAFT_01030 1.64e-155 446.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria,2MIET@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_964521_1 1109445.AGSX01000125_gene2462 2.26e-55 191.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1Z0GI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Belongs to the 5'-nucleotidase family yhcR - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_768303_1 536232.CLM_1989 2.16e-53 187.0 COG2221@1|root,COG4624@1|root,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,36E2Y@31979|Clostridiaceae 186801|Clostridia C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - FeS,Fe_hyd_lg_C,Fer4,Fer4_7,PAS k59_181139_1 1158760.AQXP01000048_gene1107 9.15e-42 139.0 COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1S8U3@1236|Gammaproteobacteria,1WYUE@135613|Chromatiales 135613|Chromatiales C Ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx k59_181139_2 272556.CF65_02262 4.19e-18 78.2 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1Y83E@135625|Pasteurellales 135625|Pasteurellales J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_408557_1 927658.AJUM01000042_gene1636 2.39e-101 305.0 COG0738@1|root,COG0738@2|Bacteria,4NEYR@976|Bacteroidetes,2FMPP@200643|Bacteroidia,3XJ71@558415|Marinilabiliaceae 976|Bacteroidetes G Major Facilitator Superfamily gluP - - - - - - - - - - - MFS_1 k59_573395_1 1168034.FH5T_12665 4.53e-20 89.0 COG0210@1|root,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,2FNIM@200643|Bacteroidia 976|Bacteroidetes L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_573395_2 1168034.FH5T_12660 3.33e-97 287.0 28H5J@1|root,2Z7I5@2|Bacteria,4NHK6@976|Bacteroidetes,2FM8F@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF4290 k59_573395_3 1168034.FH5T_12655 7.11e-107 320.0 COG0766@1|root,COG0766@2|Bacteria,4NDV8@976|Bacteroidetes,2FNYN@200643|Bacteroidia 976|Bacteroidetes M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_735408_1 864565.HMPREF0379_1157 0.000253 47.4 COG2855@1|root,COG2855@2|Bacteria,1TQYA@1239|Firmicutes,247X6@186801|Clostridia,25R1J@186804|Peptostreptococcaceae 186801|Clostridia S Conserved hypothetical protein 698 yeiH - - - - - - - - - - - Cons_hypoth698 k59_149214_1 1163617.SCD_n01160 8.1e-86 276.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria 28216|Betaproteobacteria E Extracellular solute-binding protein oppA - - - - - - - - - - - SBP_bac_5 k59_277200_1 240016.ABIZ01000001_gene354 2.14e-47 164.0 COG1039@1|root,COG1039@2|Bacteria,46V1X@74201|Verrucomicrobia,2ITVX@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Ribonuclease HII - - 3.1.26.4 ko:K03471 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_703884_1 641491.DND132_3444 2.27e-80 261.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2M8PA@213115|Desulfovibrionales 28221|Deltaproteobacteria P transporter antisigma-factor antagonist STAS - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1029967_1 373903.Hore_12510 7.28e-33 128.0 COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,3WA70@53433|Halanaerobiales 186801|Clostridia S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_345601_1 78898.MVEG_02155T0 3.53e-49 164.0 COG2947@1|root,KOG3383@2759|Eukaryota,39R2K@33154|Opisthokonta,3P2G8@4751|Fungi 4751|Fungi S AT DNA binding protein - - - - - - - - - - - - AT_hook,EVE k59_606495_1 1049564.TevJSym_aw00460 2.8e-54 179.0 COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,1RNG2@1236|Gammaproteobacteria,1J6E7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) cheZ GO:0001539,GO:0003674,GO:0003824,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032991,GO:0036211,GO:0040011,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071704,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0097588,GO:0098561,GO:0140096,GO:1901564 - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ k59_834453_1 153721.MYP_1457 6.34e-20 89.4 COG0132@1|root,COG0132@2|Bacteria,4NGKI@976|Bacteroidetes,47Q2B@768503|Cytophagia 976|Bacteroidetes H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD - 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_834453_3 1408439.JHXW01000005_gene1162 1.23e-99 300.0 COG0101@1|root,COG0101@2|Bacteria,3789X@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - KH_2,PseudoU_synth_1 k59_834453_4 596323.HMPREF0554_1186 5.44e-24 97.4 29WND@1|root,338R9@2|Bacteria,37B19@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - HD k59_834453_5 469618.FVAG_02257 3.31e-59 199.0 COG1032@1|root,COG1032@2|Bacteria,378ST@32066|Fusobacteria 32066|Fusobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_965222_1 292415.Tbd_0402 1.13e-85 272.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,1KS38@119069|Hydrogenophilales 119069|Hydrogenophilales J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_149226_1 1121875.KB907553_gene20 2.38e-100 307.0 COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_998492_2 1249627.D779_0063 4.72e-71 233.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_606499_1 1537917.JU82_09120 2.9e-193 568.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2YMHU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_899936_1 927704.SELR_01330 6.31e-19 87.0 COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,4H21H@909932|Negativicutes 909932|Negativicutes G PFAM D-galactarate dehydratase Altronate hydrolase domain protein uxaA - 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_899936_2 1168034.FH5T_12245 4.01e-35 131.0 COG0246@1|root,COG0246@2|Bacteria,4NEMT@976|Bacteroidetes,2FNTW@200643|Bacteroidia 976|Bacteroidetes G Belongs to the mannitol dehydrogenase family. UxaB subfamily uxaB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009026,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.1.1.17,1.1.1.58 ko:K00009,ko:K00041 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00631 R02555,R02703 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_703898_1 1168034.FH5T_19585 4.89e-59 196.0 COG0534@1|root,COG0534@2|Bacteria,4NDUF@976|Bacteroidetes,2G336@200643|Bacteroidia 976|Bacteroidetes V MatE - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_377045_1 1168034.FH5T_09790 5.27e-47 164.0 COG0843@1|root,COG0843@2|Bacteria,4NEH8@976|Bacteroidetes,2FXCG@200643|Bacteroidia 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family coxN - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_377045_2 1168034.FH5T_09785 5.19e-100 296.0 COG1999@1|root,COG1999@2|Bacteria,4NU1J@976|Bacteroidetes,2FXFP@200643|Bacteroidia 976|Bacteroidetes S signal sequence binding - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_965233_1 439235.Dalk_3288 4.65e-108 339.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2MIFX@213118|Desulfobacterales 28221|Deltaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,PurS k59_998508_1 1168034.FH5T_01490 9.31e-11 62.4 COG1208@1|root,COG1208@2|Bacteria,4NGYR@976|Bacteroidetes,2FMJ4@200643|Bacteroidia 976|Bacteroidetes JM Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF4954 k59_998508_2 1168034.FH5T_01485 2.04e-187 536.0 COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,2FN9H@200643|Bacteroidia 976|Bacteroidetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_573426_1 1168034.FH5T_04590 9.25e-80 258.0 COG1185@1|root,COG1185@2|Bacteria,4NE4Q@976|Bacteroidetes,2FN5H@200643|Bacteroidia 976|Bacteroidetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_377046_2 1297570.MESS4_830300 2.36e-24 97.8 COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,2UC8X@28211|Alphaproteobacteria,43K81@69277|Phyllobacteriaceae 28211|Alphaproteobacteria OU Membrane protein implicated in regulation of membrane protease activity MA20_06475 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07340 - - - - ko00000 - - - NfeD k59_115644_1 1168034.FH5T_22075 7.03e-92 275.0 COG2120@1|root,COG2120@2|Bacteria,4NEDJ@976|Bacteroidetes,2FWWN@200643|Bacteroidia 976|Bacteroidetes S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L k59_769048_1 326298.Suden_1967 4.47e-75 256.0 COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,42PR3@68525|delta/epsilon subdivisions,2YN2Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Mitochondrial degradasome RNA helicase subunit C terminal - - 3.6.4.13 ko:K17675 - - - - ko00000,ko01000,ko03029 - - - Helicase_C,SUV3_C k59_769048_2 1172190.M947_07990 3.45e-53 168.0 COG0607@1|root,COG0607@2|Bacteria,1Q1NN@1224|Proteobacteria,42U2F@68525|delta/epsilon subdivisions,2YQ1E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - k59_769048_3 929558.SMGD1_1317 2.44e-30 110.0 COG1547@1|root,COG1547@2|Bacteria,1PD94@1224|Proteobacteria,42WUE@68525|delta/epsilon subdivisions,2YQXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF309) - - - - - - - - - - - - DUF309 k59_769048_4 709032.Sulku_0062 2.48e-11 62.0 COG0778@1|root,COG0778@2|Bacteria,1N95W@1224|Proteobacteria,42RYF@68525|delta/epsilon subdivisions,2YP3N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitroreductase frxA - - - - - - - - - - - Nitroreductase k59_246016_1 879212.DespoDRAFT_01371 4.17e-96 295.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,42MIR@68525|delta/epsilon subdivisions,2WMEK@28221|Deltaproteobacteria,2MJC8@213118|Desulfobacterales 28221|Deltaproteobacteria M MBOAT, membrane-bound O-acyltransferase family algI - - ko:K19294 - - - - ko00000 - - - MBOAT k59_246018_1 596151.DesfrDRAFT_2923 1.02e-56 187.0 COG5526@1|root,COG5526@2|Bacteria,1RA0A@1224|Proteobacteria,435T0@68525|delta/epsilon subdivisions,2X081@28221|Deltaproteobacteria,2MB5I@213115|Desulfovibrionales 28221|Deltaproteobacteria M lysozyme - - - - - - - - - - - - - k59_769056_1 754436.JCM19237_5737 2.12e-22 94.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,1XUP4@135623|Vibrionales 135623|Vibrionales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_769056_2 1458427.BAWN01000006_gene357 7.74e-62 204.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,4AA63@80864|Comamonadaceae 28216|Betaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - DAO,ETF_QO,FAD_binding_2,NAD_binding_8 k59_703905_1 1121405.dsmv_2187 1.88e-60 197.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42N9E@68525|delta/epsilon subdivisions,2WJAX@28221|Deltaproteobacteria,2MI1Z@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - - ko:K22226 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_310722_1 944546.ABED_2014 2.91e-133 397.0 COG2801@1|root,COG2801@2|Bacteria,1MXCK@1224|Proteobacteria,42NGV@68525|delta/epsilon subdivisions,2YR74@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Mu transposase, C-terminal - - - ko:K07497 - - - - ko00000 - - - HTH_23,HTH_28,Mu-transpos_C,rve k59_798352_1 1168034.FH5T_21185 2.45e-120 357.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,4NE85@976|Bacteroidetes,2FNPE@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the reversible hydration of fumarate to (S)- malate fumB - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_638976_1 1161401.ASJA01000002_gene2657 2.96e-57 200.0 COG4643@1|root,COG4643@2|Bacteria,1QQ64@1224|Proteobacteria,2U2VK@28211|Alphaproteobacteria 28211|Alphaproteobacteria P DNA integration - - - - - - - - - - - - - k59_703912_1 382464.ABSI01000006_gene876 2.55e-99 298.0 COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,46WR3@74201|Verrucomicrobia,2IUSB@203494|Verrucomicrobiae 203494|Verrucomicrobiae K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - - k59_509188_1 469616.FMAG_01693 1.91e-23 98.6 COG0422@1|root,COG0422@2|Bacteria,378PD@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM k59_509188_2 469617.FUAG_01166 4.9e-102 303.0 COG1853@1|root,COG1853@2|Bacteria,378JP@32066|Fusobacteria 32066|Fusobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_509188_3 1487921.DP68_00985 9.46e-87 266.0 COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia,36ETI@31979|Clostridiaceae 186801|Clostridia C reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_115656_2 290512.Paes_0052 3.5e-16 77.8 COG1274@1|root,COG1274@2|Bacteria,1FDFQ@1090|Chlorobi 1090|Chlorobi H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_409386_1 243233.MCA1041 1.13e-26 114.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1XDNX@135618|Methylococcales 135618|Methylococcales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_899961_1 720555.BATR1942_06415 7.54e-87 286.0 COG0236@1|root,COG2227@1|root,COG3319@1|root,COG3321@1|root,COG0236@2|Bacteria,COG2227@2|Bacteria,COG3319@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HV19@91061|Bacilli,1ZD1S@1386|Bacillus 91061|Bacilli Q Polyketide synthase of type I - - - ko:K13612,ko:K13613,ko:K13615 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,NAD_binding_4,PP-binding,PS-DH,ketoacyl-synt k59_441529_1 177437.HRM2_22020 2.8e-63 202.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2WNS9@28221|Deltaproteobacteria,2MJZ8@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM VacJ family lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_834486_1 1168034.FH5T_11515 5.26e-91 279.0 COG4591@1|root,COG4591@2|Bacteria,4NFWZ@976|Bacteroidetes,2FMHC@200643|Bacteroidia 976|Bacteroidetes M Efflux ABC transporter, permease protein lolE_1 - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_769071_2 1541959.KQ51_00281 6.32e-35 126.0 COG0330@1|root,COG0330@2|Bacteria,3WT7Z@544448|Tenericutes 544448|Tenericutes O prohibitin homologues hflK_1 - - - - - - - - - - - Band_7 k59_252381_3 986075.CathTA2_1977 7.55e-44 160.0 COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,4HGWM@91061|Bacilli 91061|Bacilli LU DNA protecting protein DprA dprA GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_252381_4 1499967.BAYZ01000082_gene1010 6.73e-31 125.0 COG0172@1|root,COG0172@2|Bacteria,2NNRH@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_804732_1 1123256.KB907933_gene2329 1.94e-10 63.2 COG1538@1|root,COG1538@2|Bacteria,1MUZZ@1224|Proteobacteria,1RQEP@1236|Gammaproteobacteria,1X3VF@135614|Xanthomonadales 135614|Xanthomonadales M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_804732_2 1123257.AUFV01000015_gene3637 8.92e-40 145.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RMAD@1236|Gammaproteobacteria,1X3U7@135614|Xanthomonadales 135614|Xanthomonadales V Multidrug resistance efflux pump - - - - - - - - - - - - Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23 k59_316907_1 396588.Tgr7_0824 3.04e-95 292.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales 135613|Chromatiales T SMART Nucleotide binding protein, PINc - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_155578_1 1121438.JNJA01000023_gene366 1.24e-26 114.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_906300_1 1450525.JATV01000010_gene1613 3.02e-07 51.2 COG2067@1|root,COG2067@2|Bacteria,4NG1B@976|Bacteroidetes,1HY7J@117743|Flavobacteriia,2NTP6@237|Flavobacterium 976|Bacteroidetes I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_220608_1 749222.Nitsa_1124 4.88e-97 306.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2YM8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_415436_2 1114964.L485_11185 6.6e-07 50.4 COG3613@1|root,COG3613@2|Bacteria,1NBEC@1224|Proteobacteria 1224|Proteobacteria F nucleoside 2-deoxyribosyltransferase - - - - - - - - - - - - - k59_188105_1 289376.THEYE_A1190 3e-60 206.0 COG1061@1|root,COG3587@1|root,COG1061@2|Bacteria,COG3587@2|Bacteria 2|Bacteria L Type III restriction enzyme, res subunit resA - 3.1.21.5 ko:K01156 - - - - ko00000,ko01000,ko02048 - - - Helicase_C,ResIII k59_188105_2 289376.THEYE_A1189 1.8e-70 236.0 COG2189@1|root,COG2189@2|Bacteria,3J1DX@40117|Nitrospirae 40117|Nitrospirae H DNA methylase - - 2.1.1.72 ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_971669_1 177437.HRM2_39510 2.68e-71 231.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42SM4@68525|delta/epsilon subdivisions,2WPVD@28221|Deltaproteobacteria,2MNUX@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_775403_1 460265.Mnod_4476 2.46e-63 203.0 COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,2TS0Y@28211|Alphaproteobacteria,1JSSD@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF1611_N) Rossmann-like domain - - - - - - - - - - - - DUF1611,DUF1611_N k59_547360_2 2340.JV46_05690 1.97e-124 366.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L L COG2826 Transposase and inactivated derivatives, IS30 family insI GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_383216_1 767817.Desgi_0481 9.94e-32 125.0 COG0446@1|root,COG1148@1|root,COG0446@2|Bacteria,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,260ZH@186807|Peptococcaceae 186801|Clostridia C binding domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Pyr_redox_2 k59_804745_1 396588.Tgr7_0993 1.55e-77 241.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_579453_1 700508.D174_14835 1.06e-21 97.1 COG4221@1|root,COG4221@2|Bacteria,2GRRV@201174|Actinobacteria,233AG@1762|Mycobacteriaceae 201174|Actinobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_872934_1 1348635.BBJY01000004_gene3017 9.23e-96 290.0 COG0332@1|root,COG0332@2|Bacteria,1NAGY@1224|Proteobacteria,1RN1T@1236|Gammaproteobacteria,1Y02Q@135623|Vibrionales 135623|Vibrionales I 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal - - - - - - - - - - - - ACP_syn_III_C k59_971676_1 1207063.P24_16300 8.18e-41 153.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2JQ67@204441|Rhodospirillales 204441|Rhodospirillales C COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_645439_1 485916.Dtox_3192 9.12e-31 114.0 COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,2629C@186807|Peptococcaceae 186801|Clostridia J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_283507_1 1195236.CTER_0962 1.69e-101 307.0 COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia,3WH1J@541000|Ruminococcaceae 186801|Clostridia G glucuronate isomerase uxaC - 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - - UxaC k59_188117_1 177437.HRM2_15530 6.68e-99 305.0 COG0668@1|root,COG3064@1|root,COG0668@2|Bacteria,COG3064@2|Bacteria,1N596@1224|Proteobacteria,42Z9C@68525|delta/epsilon subdivisions,2WUFQ@28221|Deltaproteobacteria,2MN3G@213118|Desulfobacterales 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_1004811_1 1122603.ATVI01000006_gene132 2.55e-61 197.0 COG0637@1|root,COG0637@2|Bacteria,1QTT8@1224|Proteobacteria,1T1GC@1236|Gammaproteobacteria,1X6C5@135614|Xanthomonadales 135614|Xanthomonadales S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_515688_1 911045.PSE_3593 0.000183 48.9 COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the 3-hydroxyisobutyrate dehydrogenase family mmsB - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_906318_1 1121405.dsmv_0454 5.92e-83 257.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria,2MI38@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_741548_4 489653.NLA_12740 1.63e-14 80.1 COG3210@1|root,COG3210@2|Bacteria,1RIP5@1224|Proteobacteria 1224|Proteobacteria U nuclear chromosome segregation - - - - - - - - - - - - Endonuclea_NS_2,LysM,Ntox15 k59_188123_1 95619.PM1_0226985 3.07e-62 205.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_939256_1 396588.Tgr7_2292 1.93e-207 585.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_939256_2 1249627.D779_0119 7.74e-174 492.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1WW3U@135613|Chromatiales 135613|Chromatiales T PFAM PhoH family protein - - - ko:K06217 - - - - ko00000 - - - PhoH k59_939256_3 932677.PAJ_0459 3.27e-52 170.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,3VXNU@53335|Pantoea 1236|Gammaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_939256_4 572477.Alvin_2682 6.44e-128 372.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales 135613|Chromatiales P PFAM CBS domain - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_939256_5 631362.Thi970DRAFT_04194 6.77e-149 442.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_939256_6 1140.Synpcc7942_1811 4.17e-28 124.0 COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1GC86@1117|Cyanobacteria 1117|Cyanobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_4,PAS_9 k59_939256_7 526222.Desal_2643 7.6e-95 286.0 COG0725@1|root,COG0725@2|Bacteria,1QD9D@1224|Proteobacteria,42QRE@68525|delta/epsilon subdivisions,2WMW0@28221|Deltaproteobacteria,2MD3P@213115|Desulfovibrionales 28221|Deltaproteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_939256_8 1122599.AUGR01000001_gene229 1.15e-221 667.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XI40@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - 5TM-5TMR_LYT,EAL,GGDEF,PAS_9 k59_939256_9 880073.Calab_3424 7.39e-67 216.0 COG3698@1|root,COG3698@2|Bacteria,2NR44@2323|unclassified Bacteria 2|Bacteria S Phosphodiester glycosidase - - - - - - - - - - - - NAGPA k59_220631_2 314285.KT71_03472 2.47e-37 130.0 COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria,1JAGD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c soxX - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C,Cytochrome_CBB3 k59_645471_1 768671.ThimaDRAFT_0050 1.47e-102 308.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_710280_1 768671.ThimaDRAFT_2921 1.49e-38 142.0 COG3659@1|root,COG3659@2|Bacteria,1PGW8@1224|Proteobacteria,1SHC7@1236|Gammaproteobacteria 2|Bacteria M Carbohydrate-selective porin, OprB family - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB,SLH k59_1004825_1 1121405.dsmv_1658 5.39e-28 103.0 28T1G@1|root,2ZFAR@2|Bacteria,1P9FQ@1224|Proteobacteria,432CF@68525|delta/epsilon subdivisions,2WYI4@28221|Deltaproteobacteria,2MPCD@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1004825_2 1121405.dsmv_1657 5.32e-19 80.9 298U3@1|root,2ZVYA@2|Bacteria,1P6XQ@1224|Proteobacteria,432W5@68525|delta/epsilon subdivisions,2WXGU@28221|Deltaproteobacteria,2MP3E@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_316939_1 1266998.ATUJ01000003_gene1565 5.2e-86 270.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,2PUHY@265|Paracoccus 28211|Alphaproteobacteria EG Belongs to the IlvD Edd family MA20_39205 - 4.2.1.82,4.2.1.9 ko:K01687,ko:K22186 ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R02429,R04441,R05070 RC00468,RC00543,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_220632_1 1121413.JMKT01000012_gene642 3.28e-13 75.1 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,2M82C@213115|Desulfovibrionales 28221|Deltaproteobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_447890_1 1268068.PG5_16020 4.2e-41 154.0 COG0827@1|root,COG0827@2|Bacteria,1MVG5@1224|Proteobacteria,1SZ1A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L TaqI-like C-terminal specificity domain - - - - - - - - - - - - Eco57I,TaqI_C k59_547396_1 1479239.JQMU01000001_gene1554 3.35e-76 236.0 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria,2K0AT@204457|Sphingomonadales 204457|Sphingomonadales IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_939269_1 1123399.AQVE01000022_gene338 2.52e-42 148.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,462CR@72273|Thiotrichales 72273|Thiotrichales S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_54424_1 1415780.JPOG01000001_gene3066 4.34e-49 166.0 COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,1RPJA@1236|Gammaproteobacteria,1X57R@135614|Xanthomonadales 135614|Xanthomonadales S Predicted integral membrane protein (DUF2189) - - - - - - - - - - - - DUF2189 k59_54424_2 314271.RB2654_03314 3.08e-08 51.6 COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria 1224|Proteobacteria H pterin-4-alpha-carbinolamine dehydratase phhB GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_579489_1 1168034.FH5T_04420 6.41e-93 276.0 COG0024@1|root,COG0024@2|Bacteria,4NIMB@976|Bacteroidetes,2FM2H@200643|Bacteroidia 976|Bacteroidetes E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_840742_1 713587.THITH_11450 1.06e-33 120.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1WXZT@135613|Chromatiales 135613|Chromatiales S EVE domain - - - - - - - - - - - - EVE k59_840742_2 555778.Hneap_0698 2.95e-22 94.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1WYDB@135613|Chromatiales 135613|Chromatiales H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_612941_1 1249480.B649_06085 2.9e-12 63.9 COG1014@1|root,COG1014@2|Bacteria,1R8XG@1224|Proteobacteria,42NPD@68525|delta/epsilon subdivisions,2YMM0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C oxidoreductase oorC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_612941_2 709032.Sulku_1456 9.13e-74 228.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2YMMW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase oorB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1004835_1 391615.ABSJ01000022_gene309 9.76e-37 141.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J4C2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain ykoW - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_710291_1 987059.RBXJA2T_08118 6.38e-69 226.0 COG0028@1|root,COG0028@2|Bacteria,1P76A@1224|Proteobacteria,2VNC6@28216|Betaproteobacteria,1KN4R@119065|unclassified Burkholderiales 28216|Betaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_89191_1 588581.Cpap_0010 3.72e-128 406.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria 2|Bacteria IQ oxidoreductase activity - - - ko:K13612,ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - ADH_N,ADH_zinc_N,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_316951_1 1537917.JU82_02300 3.42e-178 510.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2YM8F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_804798_2 1120983.KB894576_gene3308 1.1e-12 67.8 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2TUFR@28211|Alphaproteobacteria,1JNZA@119043|Rhodobiaceae 28211|Alphaproteobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_18672_1 572544.Ilyop_0369 3.01e-69 219.0 COG0795@1|root,COG0795@2|Bacteria,379E6@32066|Fusobacteria 32066|Fusobacteria S Permease, YjgP YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_18672_2 572544.Ilyop_0370 1.21e-13 69.7 COG0612@1|root,COG0612@2|Bacteria,3785R@32066|Fusobacteria 32066|Fusobacteria S Belongs to the peptidase M16 family - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_155642_2 292.DM42_7377 1.41e-70 217.0 COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2VQUA@28216|Betaproteobacteria,1K6XY@119060|Burkholderiaceae 28216|Betaproteobacteria KT SMART metal-dependent phosphohydrolase, HD region - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - HD_4 k59_971729_1 643562.Daes_1658 2.66e-176 507.0 COG1524@1|root,COG1524@2|Bacteria,1PGPZ@1224|Proteobacteria,42NY9@68525|delta/epsilon subdivisions,2WM0S@28221|Deltaproteobacteria,2MA83@213115|Desulfovibrionales 28221|Deltaproteobacteria S PglZ domain - - - - - - - - - - - - PglZ k59_188177_1 1537917.JU82_11000 2.38e-116 343.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2YMDF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_283563_1 1479235.KK366039_gene2166 1.21e-38 141.0 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,1RP0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the dehydration of galactarate to form 5- dehydro-4-deoxy-D-glucarate garD GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008867,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0071704,GO:1901575 4.2.1.42 ko:K01708 ko00053,map00053 - R05608 RC00543 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_3790,iECP_1309.ECP_3218,iLF82_1304.LF82_0803,iNRG857_1313.NRG857_15535 GD_AH_C,SAF k59_283563_2 1410668.JNKC01000001_gene1766 1.75e-36 132.0 COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,24CFW@186801|Clostridia,36VPS@31979|Clostridiaceae 186801|Clostridia E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_384170_2 645991.Sgly_2402 4.16e-34 130.0 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,2600X@186807|Peptococcaceae 186801|Clostridia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_55079_1 1299327.I546_2473 1.57e-121 370.0 COG0719@1|root,COG1372@1|root,COG0719@2|Bacteria,COG1372@2|Bacteria,2GKCZ@201174|Actinobacteria,23407@1762|Mycobacteriaceae 201174|Actinobacteria O assembly protein SufB sufB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - ko:K09014 - - - - ko00000 - - - UPF0051 k59_317532_1 379066.GAU_2561 1.51e-77 244.0 COG0626@1|root,COG0626@2|Bacteria 2|Bacteria E cystathionine gamma-synthase activity - - 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 ko:K01739,ko:K01758,ko:K01760,ko:K01761,ko:K10764 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_841371_1 760192.Halhy_3670 3.64e-68 224.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,4NM18@976|Bacteroidetes,1INYM@117747|Sphingobacteriia 976|Bacteroidetes C COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2 k59_55081_1 865938.Weevi_0834 2.68e-64 206.0 COG4912@1|root,COG4912@2|Bacteria,4NKBS@976|Bacteroidetes,1I0QG@117743|Flavobacteriia 976|Bacteroidetes L DNA alkylation repair - - - - - - - - - - - - DNA_alkylation k59_646193_2 1168034.FH5T_06485 2.58e-106 332.0 COG3291@1|root,COG4447@1|root,COG3291@2|Bacteria,COG4447@2|Bacteria,4NGJJ@976|Bacteroidetes,2FRXF@200643|Bacteroidia 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - - k59_481300_1 1123277.KB893239_gene1246 4.98e-12 68.9 28I8D@1|root,2ZBHJ@2|Bacteria,4NHI9@976|Bacteroidetes,47KUP@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF4249) - - - - - - - - - - - - DUF4249 k59_481300_2 1408473.JHXO01000008_gene2798 2.44e-44 161.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,2FM7I@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_580328_1 1265505.ATUG01000001_gene3526 2.51e-15 73.6 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales 28221|Deltaproteobacteria N ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_618785_1 1049564.TevJSym_bb00050 5.1e-75 243.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_226488_1 1168034.FH5T_10705 6.75e-76 239.0 COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes,2FPA0@200643|Bacteroidia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP k59_127701_1 758.BBIX01000006_gene564 1.41e-11 69.7 COG2885@1|root,COG2885@2|Bacteria,1MZAH@1224|Proteobacteria,1S5A3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA k59_810427_1 1168034.FH5T_10660 3e-45 157.0 COG3595@1|root,COG3595@2|Bacteria,4NSAQ@976|Bacteroidetes,2FUXZ@200643|Bacteroidia 976|Bacteroidetes S Putative auto-transporter adhesin, head GIN domain - - - - - - - - - - - - DUF2807 k59_60634_1 83406.HDN1F_29020 5.78e-60 199.0 2CBBK@1|root,2ZADC@2|Bacteria,1R4ED@1224|Proteobacteria,1RS9S@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_60634_2 1442599.JAAN01000014_gene3423 1.61e-26 108.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1X6T3@135614|Xanthomonadales 135614|Xanthomonadales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,HAMP,Pkinase,sCache_3_2 k59_1010192_1 395493.BegalDRAFT_0029 1.55e-22 92.4 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,4610Q@72273|Thiotrichales 72273|Thiotrichales S Stringent starvation protein B - - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_1010192_2 472759.Nhal_0471 3.57e-30 118.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales 135613|Chromatiales C PFAM FAD linked oxidase domain protein - - 1.1.5.12 ko:K03777 ko00620,ko01120,map00620,map01120 - R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_162172_1 572544.Ilyop_0527 2.82e-08 55.1 COG4974@1|root,COG4974@2|Bacteria,378JM@32066|Fusobacteria 32066|Fusobacteria L Belongs to the 'phage' integrase family xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_162172_2 572544.Ilyop_0528 1.04e-91 271.0 COG5405@1|root,COG5405@2|Bacteria,379EC@32066|Fusobacteria 32066|Fusobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_162172_3 572544.Ilyop_0529 6.39e-112 333.0 COG1161@1|root,COG1161@2|Bacteria,378AK@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 yqeH - - ko:K06948 - - - - ko00000,ko03009 - - - MMR_HSR1 k59_553921_1 1492738.FEM21_11280 2.66e-07 52.4 COG5434@1|root,COG5434@2|Bacteria,4NEM8@976|Bacteroidetes,1HYB5@117743|Flavobacteriia,2NUI1@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_553921_2 1168034.FH5T_00855 1.84e-69 228.0 COG5434@1|root,COG5434@2|Bacteria,4NG9X@976|Bacteroidetes,2FP9N@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_715807_1 1168034.FH5T_16930 2.35e-120 378.0 COG0755@1|root,COG0755@2|Bacteria,4NDY1@976|Bacteroidetes,2FKZ1@200643|Bacteroidia 976|Bacteroidetes O cytochrome c-type biogenesis protein CcsB ccsA - - - - - - - - - - - Cytochrom_C_asm,ResB k59_127712_1 1168034.FH5T_01865 1.78e-67 218.0 COG2885@1|root,COG2885@2|Bacteria,4NE8J@976|Bacteroidetes 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - OMP_b-brl,OmpA,TSP_3 k59_289397_1 457424.BFAG_01871 6.79e-29 113.0 COG0673@1|root,COG0673@2|Bacteria,4NEQB@976|Bacteroidetes,2FPVB@200643|Bacteroidia,4AP0A@815|Bacteroidaceae 976|Bacteroidetes S Oxidoreductase family, C-terminal alpha/beta domain yvaA - 1.1.1.371 ko:K16044 ko00562,ko01120,map00562,map01120 - R09954 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_289397_2 1168034.FH5T_21235 9.45e-46 155.0 COG1102@1|root,COG1102@2|Bacteria,4NU66@976|Bacteroidetes 976|Bacteroidetes F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 k59_420843_1 631362.Thi970DRAFT_00772 1.77e-36 130.0 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1WYKN@135613|Chromatiales 135613|Chromatiales L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_420843_2 1163617.SCD_n00964 1.41e-39 145.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria 28216|Betaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_846075_1 387093.SUN_1039 2.95e-101 306.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42M1K@68525|delta/epsilon subdivisions,2YMKR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the peptidase M24B family pepQ - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C k59_684317_1 1244531.CIG1485E_0833 1.91e-12 63.2 COG1188@1|root,COG1188@2|Bacteria,1Q5X3@1224|Proteobacteria,42VKA@68525|delta/epsilon subdivisions,2YPZ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J S4 domain protein - - - - - - - - - - - - S4 k59_684317_2 929558.SMGD1_2610 6.54e-146 421.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2YN78@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase,Glycos_trans_3N,Glycos_transf_3 k59_585833_1 631362.Thi970DRAFT_02736 8.53e-32 117.0 COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,1T1KA@1236|Gammaproteobacteria,1X2U2@135613|Chromatiales 135613|Chromatiales F Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_1010206_1 926569.ANT_10490 3.03e-58 201.0 28J5T@1|root,2Z91J@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_289790_2 485915.Dret_1435 2.91e-39 134.0 COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria,2MBZC@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Cupin 2 conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_25077_1 1095769.CAHF01000017_gene17 6.23e-135 400.0 COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,2W139@28216|Betaproteobacteria 28216|Betaproteobacteria V COG4257 Streptogramin lyase - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - CarboxypepD_reg k59_25077_2 247634.GPB2148_2639 1.24e-14 74.3 COG1520@1|root,COG1520@2|Bacteria,1QU2U@1224|Proteobacteria,1S1NX@1236|Gammaproteobacteria,1J7KA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PQQ-like domain - - 1.1.2.6 ko:K05889 - - R03136 - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3 k59_95306_1 1174528.JH992898_gene1349 3.81e-58 205.0 COG1080@1|root,COG1080@2|Bacteria,1G0VI@1117|Cyanobacteria,1JHDA@1189|Stigonemataceae 1117|Cyanobacteria G PTS HPr component phosphorylation site - - 2.7.1.202,2.7.3.9 ko:K02768,ko:K08483,ko:K11183 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_1,PTS_EIIA_2 k59_322484_1 316067.Geob_2800 2.78e-56 184.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_747537_1 98439.AJLL01000052_gene3679 4.97e-55 184.0 28IH6@1|root,2Z8IF@2|Bacteria,1G1B5@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_684970_1 2340.JV46_28920 2.26e-43 141.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1SCFA@1236|Gammaproteobacteria,1J6VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the sulfur carrier protein TusA family - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_61163_1 575540.Isop_2246 6.98e-69 234.0 COG2204@1|root,COG2204@2|Bacteria,2IYP4@203682|Planctomycetes 203682|Planctomycetes T Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains - - - - - - - - - - - - HTH_8,Sigma54_activat k59_128322_1 1121921.KB898707_gene1225 1.2e-48 167.0 COG3977@1|root,COG3977@2|Bacteria,1MVRW@1224|Proteobacteria,1RNK1@1236|Gammaproteobacteria,2PN20@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E Aminotransferase class I and II avtA - 2.6.1.66 ko:K00835 ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130 - R01215 RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_128322_2 269796.Rru_A1534 8.89e-08 56.2 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,2JPA6@204441|Rhodospirillales 204441|Rhodospirillales P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_684976_1 385682.AFSL01000041_gene287 2.89e-76 249.0 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,4PMJN@976|Bacteroidetes,2G0DR@200643|Bacteroidia,3XM22@558415|Marinilabiliaceae 976|Bacteroidetes P Sodium/hydrogen exchanger family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_945961_1 765914.ThisiDRAFT_0968 2.05e-59 202.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1WX1A@135613|Chromatiales 135613|Chromatiales T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_162748_2 1123326.JFBL01000013_gene326 4.12e-53 169.0 COG1433@1|root,COG1433@2|Bacteria,1RDPR@1224|Proteobacteria,42UYN@68525|delta/epsilon subdivisions,2YPWH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_162748_3 387093.SUN_1052 3.14e-68 214.0 COG0189@1|root,COG0189@2|Bacteria,1R4ZF@1224|Proteobacteria,42PG3@68525|delta/epsilon subdivisions,2YMQ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_586475_1 1535422.ND16A_0237 4.95e-88 292.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q6IX@267889|Colwelliaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1010930_1 401526.TcarDRAFT_1233 0.000488 43.1 COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4H4YZ@909932|Negativicutes 909932|Negativicutes CO Periplasmic protein thiol disulfide oxidoreductase, DsbE subfamily dsbE - - - - - - - - - - - AhpC-TSA,Redoxin k59_1010930_2 387092.NIS_1744 1.36e-06 52.8 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,42Q44@68525|delta/epsilon subdivisions,2YNTJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_912246_1 929556.Solca_2393 1.58e-82 278.0 COG1404@1|root,COG1404@2|Bacteria,4NHSQ@976|Bacteroidetes,1IWJ1@117747|Sphingobacteriia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_421270_1 598467.BrE312_1114 4.47e-14 78.2 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S3IY@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - ko:K12549 - - - - ko00000 - - - Calx-beta,HemolysinCabind,VWA,VWA_2 k59_455794_1 1168034.FH5T_06165 1.19e-175 521.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FWCM@200643|Bacteroidia 976|Bacteroidetes V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_811162_1 98439.AJLL01000089_gene3730 3.43e-231 670.0 COG0542@1|root,COG0542@2|Bacteria,1G04Z@1117|Cyanobacteria,1JHRT@1189|Stigonemataceae 1117|Cyanobacteria O C-terminal, D2-small domain, of ClpB protein clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_912254_1 1201288.M900_1827 1.05e-56 177.0 COG5531@1|root,COG5531@2|Bacteria 2|Bacteria B SWIB/MDM2 domain CP_0171 - - - - - - - - - - - SWIB k59_747572_2 1249480.B649_03165 2.73e-10 60.5 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2YN91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1010940_1 1172190.M947_06500 2.97e-89 285.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2YMFS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_586487_1 1122165.AUHS01000046_gene2436 1.05e-14 75.9 2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - k59_390893_1 469618.FVAG_01170 2.03e-151 446.0 COG1148@1|root,COG1148@2|Bacteria,378N8@32066|Fusobacteria 32066|Fusobacteria C NAD(P)-binding Rossmann-like domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Pyr_redox_2 k59_912255_1 572544.Ilyop_0552 2.92e-97 286.0 COG0225@1|root,COG0225@2|Bacteria,37C62@32066|Fusobacteria 32066|Fusobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11,1.8.4.12 ko:K12267 - - - - ko00000,ko01000 - - - PMSR k59_357981_1 998674.ATTE01000001_gene2454 1.91e-178 510.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,46096@72273|Thiotrichales 72273|Thiotrichales C Belongs to the heme-copper respiratory oxidase family cyoB - 1.10.3.10,1.9.3.1 ko:K02274,ko:K02298 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6 - - COX1 k59_651400_1 290402.Cbei_1621 2.07e-39 144.0 COG3723@1|root,COG3723@2|Bacteria,1V4M6@1239|Firmicutes,24CV2@186801|Clostridia,36GFQ@31979|Clostridiaceae 186801|Clostridia L Recombinational DNA repair protein (RecE pathway) - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_912257_1 1168034.FH5T_12795 3.21e-81 241.0 COG0048@1|root,COG0048@2|Bacteria,4NM3Y@976|Bacteroidetes,2FRY7@200643|Bacteroidia 976|Bacteroidetes J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_554570_1 326297.Sama_1566 5.95e-40 149.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,2QAXB@267890|Shewanellaceae 1236|Gammaproteobacteria M TIGRFAM gamma-glutamyltransferase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706 G_glu_transpept k59_811183_1 745411.B3C1_04635 5.24e-111 345.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1J98P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Domain of unknown function (DUF1974) fadE GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0217 Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_162782_1 1321779.HMPREF1984_01089 3.49e-102 319.0 COG0323@1|root,COG0323@2|Bacteria,378NQ@32066|Fusobacteria 32066|Fusobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_322535_1 1168034.FH5T_10690 7.03e-102 299.0 COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,2FNRG@200643|Bacteroidia 976|Bacteroidetes V ABC transporter, ATP-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_977887_1 1348635.BBJY01000013_gene1007 4.13e-117 352.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1XT8T@135623|Vibrionales 135623|Vibrionales T Serine protein kinase prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_586498_2 247639.MGP2080_08826 4.51e-24 101.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1S00K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_289832_1 998674.ATTE01000001_gene3129 1.04e-86 263.0 COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,1RXYN@1236|Gammaproteobacteria 1236|Gammaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - Radical_SAM k59_554576_1 666685.R2APBS1_3141 5.02e-09 55.5 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,1SA62@1236|Gammaproteobacteria,1XD2Z@135614|Xanthomonadales 135614|Xanthomonadales G Phosphotransferase system, mannose fructose-specific component IIA - - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_554576_2 1046724.KB889827_gene2658 2.07e-73 233.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,464DI@72275|Alteromonadaceae 1236|Gammaproteobacteria S Displays ATPase and GTPase activities rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_390908_2 1408254.T458_23055 3.93e-40 149.0 COG2223@1|root,COG2223@2|Bacteria,1UJR3@1239|Firmicutes,4ITDR@91061|Bacilli,26S65@186822|Paenibacillaceae 91061|Bacilli P COG0477 Permeases of the major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_747593_1 226186.BT_4178 2.1e-58 211.0 COG0745@1|root,COG2207@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2207@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia,4AN96@815|Bacteroidaceae 976|Bacteroidetes T Response regulator receiver domain - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_455820_1 1249480.B649_09175 5.71e-100 301.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2YMZM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_95351_1 448385.sce4763 1.09e-61 211.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2X37C@28221|Deltaproteobacteria,2YUQZ@29|Myxococcales 28221|Deltaproteobacteria S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT k59_586503_2 1408439.JHXW01000001_gene1936 8.53e-56 177.0 COG0757@1|root,COG0757@2|Bacteria,37A0B@32066|Fusobacteria 32066|Fusobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_95353_1 396588.Tgr7_2713 1.82e-06 50.1 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_95353_2 1033802.SSPSH_000357 2.94e-16 82.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0033890,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_811200_1 414684.RC1_1366 8.72e-50 169.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,2JPP5@204441|Rhodospirillales 204441|Rhodospirillales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_486429_2 1045856.EcWSU1_01792 1.27e-11 62.4 COG1447@1|root,COG1447@2|Bacteria,1RI0T@1224|Proteobacteria,1S75F@1236|Gammaproteobacteria,3X2JI@547|Enterobacter 1236|Gammaproteobacteria G lactose cellobiose-specific IIA subunit chbA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0009987,GO:0015144,GO:0016043,GO:0016740,GO:0016772,GO:0016773,GO:0022607,GO:0022804,GO:0022857,GO:0034219,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0071702,GO:0071840,GO:0090563,GO:0090566,GO:1901264,GO:1902815 2.7.1.196,2.7.1.205 ko:K02759 ko00500,ko02060,map00500,map02060 M00275 R11170,R11172 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.3.2 - iECUMN_1333.ECUMN_2025 PTS_IIA k59_522482_1 927658.AJUM01000037_gene2132 8.27e-60 196.0 COG1312@1|root,COG1312@2|Bacteria,4NFA5@976|Bacteroidetes,2FM15@200643|Bacteroidia,3XJGR@558415|Marinilabiliaceae 976|Bacteroidetes G D-mannonate dehydratase (UxuA) uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - UxuA k59_322574_1 391615.ABSJ01000054_gene1390 1.28e-71 240.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1J4DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_486448_2 861299.J421_4068 4.02e-12 68.6 COG0515@1|root,COG0515@2|Bacteria,1ZTGA@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_846783_1 326298.Suden_0726 4.09e-46 149.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2YPU9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_358053_1 323848.Nmul_A1598 7.22e-13 67.8 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ9H@28216|Betaproteobacteria,3722H@32003|Nitrosomonadales 28216|Betaproteobacteria S ABC1 family - - - ko:K03688 - - - - ko00000 - - - ABC1,Usp k59_716391_1 1121405.dsmv_2787 4.36e-114 346.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,2MI30@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_685081_1 395493.BegalDRAFT_3318 3.72e-82 266.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,4608B@72273|Thiotrichales 72273|Thiotrichales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_619454_1 977880.pRALTA_0338 3.37e-23 103.0 COG1520@1|root,COG1520@2|Bacteria,1NTVM@1224|Proteobacteria 1224|Proteobacteria S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_687802_2 1408422.JHYF01000013_gene485 1.18e-94 291.0 COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,249F8@186801|Clostridia,36FBR@31979|Clostridiaceae 186801|Clostridia S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - Acetyltransf_1,RsgA_GTPase k59_687802_3 572544.Ilyop_1221 8.97e-106 325.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,378BF@32066|Fusobacteria 32066|Fusobacteria C PFAM hydrogenase large subunit domain protein - - 1.12.1.2,1.12.1.3 ko:K18006,ko:K18332 - - - - ko00000,ko01000 - - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3 k59_328328_2 572480.Arnit_0603 2.49e-52 166.0 COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42U0X@68525|delta/epsilon subdivisions,2YPSD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 k59_328328_3 572480.Arnit_0604 1.1e-233 650.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,42MHN@68525|delta/epsilon subdivisions,2YMYK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Involved in arsenical resistance. Thought to form the channel of an arsenite pump arsB - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - ArsB k59_328328_4 944547.ABLL_0313 1.5e-70 214.0 COG0394@1|root,COG0394@2|Bacteria,1REU2@1224|Proteobacteria,42SC5@68525|delta/epsilon subdivisions,2YPPW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Low molecular weight phosphotyrosine protein phosphatase arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_557159_1 679200.HMPREF9333_01016 0.000849 42.4 COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia 186801|Clostridia H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_557159_2 1280689.AUJC01000004_gene455 8.85e-39 132.0 COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,36KHC@31979|Clostridiaceae 186801|Clostridia J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_753166_1 387093.SUN_1939 4.23e-27 111.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2YTKV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Bacterial sugar transferase - - 2.7.8.6 ko:K00996 - - - - ko00000,ko01000,ko01005 - - - Bac_transf k59_328331_1 572544.Ilyop_1500 1.78e-93 281.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_328331_2 572544.Ilyop_1501 4.9e-22 93.2 COG1623@1|root,COG1623@2|Bacteria,378ZQ@32066|Fusobacteria 32066|Fusobacteria H Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process disA - 2.7.7.85 ko:K07067 - - - - ko00000,ko01000 - - - DisA-linker,DisA_N k59_426205_1 96561.Dole_1305 4.12e-77 248.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42YAX@68525|delta/epsilon subdivisions,2WU3C@28221|Deltaproteobacteria,2MMI7@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_132094_1 1121447.JONL01000006_gene33 1.35e-22 95.9 COG0745@1|root,COG0745@2|Bacteria,1N0XC@1224|Proteobacteria,42TRF@68525|delta/epsilon subdivisions,2WQDP@28221|Deltaproteobacteria,2MBQ4@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_818517_1 1168034.FH5T_20355 5.48e-133 400.0 COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes 976|Bacteroidetes E Aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_491623_1 1168034.FH5T_12375 1.1e-89 267.0 COG2518@1|root,COG2518@2|Bacteria,4NFCU@976|Bacteroidetes,2FSTZ@200643|Bacteroidia 976|Bacteroidetes O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_459049_1 1565314.OA34_02915 7.77e-14 67.4 COG1393@1|root,COG1393@2|Bacteria,1MZ7Z@1224|Proteobacteria,42VII@68525|delta/epsilon subdivisions 1224|Proteobacteria P Belongs to the ArsC family - - - - - - - - - - - - ArsC k59_459049_2 1165841.SULAR_02583 3.18e-104 317.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,42MQD@68525|delta/epsilon subdivisions,2YNHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0659 Sulfate permease and related - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1014640_1 1123367.C666_12810 1.05e-50 174.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KV7X@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_361046_1 945713.IALB_1666 2.14e-114 360.0 COG1290@1|root,COG1290@2|Bacteria 2|Bacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_B_N_2,Cytochrome_B k59_132108_1 880073.Calab_0276 7.96e-109 336.0 COG1523@1|root,COG1523@2|Bacteria,2NPQU@2323|unclassified Bacteria 2|Bacteria G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_459059_1 1453501.JELR01000002_gene72 7.98e-19 94.4 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,4665R@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - Pertussis_S1,RHS,RHS_repeat k59_557169_1 1049564.TevJSym_ap00560 0.0 936.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1J62R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_557169_2 1049564.TevJSym_ap00550 2.74e-43 151.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1J5UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_491636_2 3880.AES58543 1.57e-42 147.0 COG1005@1|root,KOG4770@2759|Eukaryota,37XCB@33090|Viridiplantae,3GKQH@35493|Streptophyta 35493|Streptophyta C NADH-ubiquinone oxidoreductase chain - - 1.6.5.3 ko:K03878 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - NADHdh k59_655227_1 293826.Amet_3602 2.12e-150 434.0 COG0673@1|root,COG0673@2|Bacteria,1TR8S@1239|Firmicutes,25AZV@186801|Clostridia,36DGC@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - 1.1.1.371 ko:K16044 ko00562,ko01120,map00562,map01120 - R09954 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_655227_2 572544.Ilyop_0505 1.4e-109 325.0 COG2816@1|root,COG2816@2|Bacteria 2|Bacteria L NAD+ diphosphatase activity nudC - 1.3.7.1,3.6.1.22 ko:K03426,ko:K20449 ko00760,ko01100,ko01120,ko04146,map00760,map01100,map01120,map04146 - R00103,R03004,R03164,R11104 RC00002,RC02422 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_655227_5 1499967.BAYZ01000030_gene1158 1.22e-117 353.0 COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria 2|Bacteria E Aminotransferase aspB - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_655227_7 663278.Ethha_2675 2.32e-12 63.9 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,3WJA1@541000|Ruminococcaceae 186801|Clostridia G Ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_949329_2 1158756.AQXQ01000012_gene2038 7.31e-64 212.0 COG0540@1|root,COG0540@2|Bacteria,1R3Q5@1224|Proteobacteria,1RYCN@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family - - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_328353_1 633149.Bresu_2908 3.73e-37 138.0 COG2211@1|root,COG2211@2|Bacteria,1MX4Z@1224|Proteobacteria,2TTX5@28211|Alphaproteobacteria,2KHMH@204458|Caulobacterales 204458|Caulobacterales G PFAM major facilitator superfamily MFS_1 - - - ko:K16211 - - - - ko00000,ko02000 2.A.2.6 - - MFS_1 k59_328353_2 1168034.FH5T_08535 5.35e-40 146.0 COG1554@1|root,COG1554@2|Bacteria,4NFG1@976|Bacteroidetes,2FME6@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolase family 65 central catalytic domain - - 2.4.1.8 ko:K00691 ko00500,ko01100,map00500,map01100 - R01555 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m k59_981898_1 177437.HRM2_01970 2.02e-47 170.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2MHS3@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM NADH flavin oxidoreductase NADH oxidase - - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_164935_1 313612.L8106_25867 3.85e-41 147.0 COG1397@1|root,COG1397@2|Bacteria,1G437@1117|Cyanobacteria,1H9KV@1150|Oscillatoriales 1117|Cyanobacteria O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_164935_2 56780.SYN_00667 1.08e-121 357.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_164935_3 655815.ZPR_2321 1.65e-30 116.0 COG0668@1|root,COG0668@2|Bacteria,4NMMB@976|Bacteroidetes,1I2BV@117743|Flavobacteriia 976|Bacteroidetes M mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_491642_1 1158762.KB898041_gene1210 4.82e-51 164.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1WYPB@135613|Chromatiales 135613|Chromatiales FG PFAM Histidine triad (HIT) protein - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_491642_2 631362.Thi970DRAFT_03826 1.95e-50 166.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1WY1A@135613|Chromatiales 135613|Chromatiales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_655237_1 443143.GM18_2132 5.34e-24 101.0 COG0318@1|root,COG0318@2|Bacteria,1R5I6@1224|Proteobacteria,42MKC@68525|delta/epsilon subdivisions,2WK3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.1.3.1 ko:K22319 - - - - ko00000,ko01000 - - - AMP-binding k59_655237_2 1210884.HG799465_gene11984 3.67e-22 95.1 COG0451@1|root,COG0451@2|Bacteria,2IX97@203682|Planctomycetes 203682|Planctomycetes M PFAM 3-beta hydroxysteroid dehydrogenase isomerase - - 1.1.1.412 ko:K22320 - - - - ko00000,ko01000 - - - 3Beta_HSD k59_361063_1 1121935.AQXX01000124_gene120 1.33e-18 89.0 COG2866@1|root,COG4935@1|root,COG2866@2|Bacteria,COG4935@2|Bacteria,1PFUZ@1224|Proteobacteria,1RYRG@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Zn_pept - - - - - - - - - - - - PKD,P_proprotein,Peptidase_M14 k59_164945_1 2340.JV46_21020 2.05e-187 531.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1J4TX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_818555_1 78898.MVEG_02603T0 6.81e-107 326.0 COG0129@1|root,KOG2448@2759|Eukaryota,38F28@33154|Opisthokonta,3NUBR@4751|Fungi,1GS3V@112252|Fungi incertae sedis 4751|Fungi E Dehydratase family ILV3 GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006549,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_393683_1 187272.Mlg_2026 5.75e-08 53.1 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,1S4H2@1236|Gammaproteobacteria,1WXZI@135613|Chromatiales 135613|Chromatiales C Hydrogenase expression formation protein - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_393683_2 983917.RGE_35780 9.49e-98 292.0 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,2VI8M@28216|Betaproteobacteria,1KJVE@119065|unclassified Burkholderiales 28216|Betaproteobacteria C TIGRFAM Ni Fe-hydrogenase, b-type cytochrome subunit hoxZ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_393683_3 870187.Thini_0248 1.58e-19 87.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hydB - 1.12.5.1,1.12.99.6 ko:K05922,ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_361073_1 563040.Saut_0423 5.25e-61 198.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42QA8@68525|delta/epsilon subdivisions,2YNH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA_3 k59_33963_1 1265507.KB899636_gene1267 8.1e-06 55.5 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1Y409@135624|Aeromonadales 135624|Aeromonadales L Phage integrase, N-terminal SAM-like domain xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_33963_3 118173.KB235914_gene2270 1.69e-10 64.7 COG0494@1|root,COG0494@2|Bacteria,1G22W@1117|Cyanobacteria,1H7UC@1150|Oscillatoriales 1117|Cyanobacteria L PFAM NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_33963_4 572544.Ilyop_1892 3.88e-84 259.0 2F605@1|root,33YIM@2|Bacteria,37CCM@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_33963_6 1380408.AVGH01000029_gene73 0.0 897.0 COG0425@1|root,COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0425@2|Bacteria,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,4HA11@91061|Bacilli,21WMD@150247|Anoxybacillus 91061|Bacilli OP DsrE/DsrF-like family - - - - - - - - - - - - DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA k59_33963_7 33035.JPJF01000036_gene1748 1.69e-14 70.9 COG1476@1|root,COG1476@2|Bacteria,1UUV5@1239|Firmicutes,25KCX@186801|Clostridia,3Y0TB@572511|Blautia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_33963_8 1121324.CLIT_10c02990 4.06e-62 196.0 COG0348@1|root,COG0348@2|Bacteria,1UHUA@1239|Firmicutes,24BED@186801|Clostridia 186801|Clostridia C Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Fer4_5 k59_33963_9 926692.AZYG01000079_gene386 2.86e-36 135.0 COG0500@1|root,COG2226@2|Bacteria,1V6QV@1239|Firmicutes,24JPQ@186801|Clostridia,3WBXZ@53433|Halanaerobiales 186801|Clostridia Q Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_33963_10 469618.FVAG_02414 3.53e-88 261.0 COG2131@1|root,COG2131@2|Bacteria,3794S@32066|Fusobacteria 32066|Fusobacteria F MafB19-like deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_753167_1 1121342.AUCO01000016_gene2779 6.17e-97 297.0 COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,24YI0@186801|Clostridia,36ED9@31979|Clostridiaceae 186801|Clostridia E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_753167_2 1123288.SOV_2c03040 6.88e-146 424.0 COG1454@1|root,COG1454@2|Bacteria,1TQMF@1239|Firmicutes,4H3SH@909932|Negativicutes 909932|Negativicutes C Alcohol dehydrogenase iron-dependent - - 1.1.1.61 ko:K18120 ko00650,ko01100,ko01200,map00650,map01100,map01200 - R01644 RC00087 ko00000,ko00001,ko01000 - - - Fe-ADH k59_753167_3 572544.Ilyop_0595 6.84e-24 90.9 COG1773@1|root,COG1773@2|Bacteria 2|Bacteria C rubredoxin - - - - - - - - - - - - PCP_red,Rubredoxin,Usp k59_753167_5 1280689.AUJC01000007_gene3176 1.83e-93 300.0 COG0248@1|root,COG0248@2|Bacteria,1TS3I@1239|Firmicutes,248EW@186801|Clostridia,36FHQ@31979|Clostridiaceae 186801|Clostridia FP Ppx GppA phosphatase - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA k59_753167_6 1408304.JAHA01000019_gene2321 3.56e-40 160.0 COG0248@1|root,COG0248@2|Bacteria,1TS3I@1239|Firmicutes,248EW@186801|Clostridia,4BWT6@830|Butyrivibrio 186801|Clostridia FP Ppx/GppA phosphatase family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA k59_753167_7 526218.Sterm_1105 9.53e-46 165.0 COG0855@1|root,COG0855@2|Bacteria,379PC@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_785819_1 1244528.CFT03427_0204 2.18e-28 116.0 COG1293@1|root,COG1293@2|Bacteria,1P028@1224|Proteobacteria,42MKF@68525|delta/epsilon subdivisions,2YN21@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Fibronectin fibrinogen-binding protein - - - - - - - - - - - - DUF814,FbpA k59_132119_1 484770.UFO1_3156 5.91e-127 370.0 COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,4H51I@909932|Negativicutes 909932|Negativicutes K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_132119_3 484770.UFO1_3157 3.5e-229 638.0 COG0673@1|root,COG0673@2|Bacteria,1UZEK@1239|Firmicutes,4H77I@909932|Negativicutes 909932|Negativicutes S PFAM oxidoreductase domain protein, Oxidoreductase domain-containing protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_132119_4 1116375.VEJY3_08610 1.06e-10 60.8 COG1082@1|root,COG1082@2|Bacteria,1MW1Z@1224|Proteobacteria,1RZT0@1236|Gammaproteobacteria 1236|Gammaproteobacteria G AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N k59_459083_1 572544.Ilyop_1904 1.07e-35 126.0 COG1847@1|root,COG1847@2|Bacteria,378FR@32066|Fusobacteria 32066|Fusobacteria S Putative single-stranded nucleic acids-binding domain - - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H k59_459083_2 469618.FVAG_02452 1.55e-169 486.0 COG0486@1|root,COG0486@2|Bacteria,378J5@32066|Fusobacteria 32066|Fusobacteria S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_1014669_1 709032.Sulku_0432 1.56e-124 378.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2YMW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_524415_1 765911.Thivi_4176 1.03e-104 313.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1WX6F@135613|Chromatiales 135613|Chromatiales I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_524415_2 631362.Thi970DRAFT_01930 1.85e-78 267.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales 135613|Chromatiales U Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_524415_3 391625.PPSIR1_08746 5.1e-101 305.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,43BQ2@68525|delta/epsilon subdivisions,2WQ6X@28221|Deltaproteobacteria,2Z2WS@29|Myxococcales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - FHA,GGDEF,Yop-YscD_cpl k59_524415_4 1049564.TevJSym_as00710 2.29e-214 602.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1J5GP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404 GlutR_N,GlutR_dimer,Shikimate_DH k59_524415_5 1049564.TevJSym_as00720 7.81e-196 550.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1J58N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_524415_6 768671.ThimaDRAFT_0292 2.1e-84 263.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1WXSH@135613|Chromatiales 135613|Chromatiales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_524415_7 395494.Galf_0202 9.34e-101 312.0 COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria,1Q1EG@1224|Proteobacteria,2VMXN@28216|Betaproteobacteria,44VCC@713636|Nitrosomonadales 28216|Betaproteobacteria G BNR repeat-like domain - - - - - - - - - - - - BNR_2 k59_524415_8 1485545.JQLW01000007_gene580 2.74e-18 85.9 2ETRW@1|root,33M9C@2|Bacteria,1NEBE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_524415_9 862908.BMS_3032 3.55e-53 177.0 2AFPW@1|root,315RN@2|Bacteria,1N1K1@1224|Proteobacteria,42WWK@68525|delta/epsilon subdivisions,2WSXP@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_524415_10 156889.Mmc1_0897 2.17e-236 659.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_524415_11 1049564.TevJSym_as00750 1.6e-113 332.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1J5KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family moeB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0061605,GO:0070566,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - iECIAI1_1343.ECIAI1_0865,iECW_1372.ECW_m0884,iEKO11_1354.EKO11_3059,iETEC_1333.ETEC_0893,iEcE24377_1341.EcE24377A_0897,iEcSMS35_1347.EcSMS35_0851,iWFL_1372.ECW_m0884 ThiF k59_524415_12 519989.ECTPHS_03789 1.48e-93 278.0 COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria,1WW4H@135613|Chromatiales 135613|Chromatiales J PFAM methyltransferase small - - - - - - - - - - - - MTS,MTS_N k59_524415_13 709032.Sulku_0263 4.32e-81 259.0 COG0840@1|root,COG0840@2|Bacteria,1R5W9@1224|Proteobacteria,42SRV@68525|delta/epsilon subdivisions,2YR7J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein - - - - - - - - - - - - CZB,MCPsignal k59_34391_1 762968.HMPREF9441_02104 3.03e-86 285.0 COG2335@1|root,COG2335@2|Bacteria,4NI6Z@976|Bacteroidetes 976|Bacteroidetes M Pfam Fasciclin domain - - - - - - - - - - - - DUF4993,Fasciclin k59_525059_1 1408424.JHYI01000011_gene1343 2.5e-34 133.0 COG4294@1|root,COG4294@2|Bacteria,1TTCB@1239|Firmicutes,4H9PY@91061|Bacilli,1ZCJ7@1386|Bacillus 91061|Bacilli L Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion uvsE - - ko:K13281 - - - - ko00000,ko01000 - - - DUF1722,UvdE k59_753651_1 264198.Reut_B3916 5.12e-105 308.0 COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,2VJ36@28216|Betaproteobacteria,1K3TM@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily menB - - ko:K07536 ko00362,ko01120,ko01220,map00362,map01120,map01220 M00540 R05592 RC01429 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_296128_1 1168034.FH5T_05395 7.43e-80 245.0 COG0811@1|root,COG0811@2|Bacteria,4NEA2@976|Bacteroidetes,2FMMQ@200643|Bacteroidia 976|Bacteroidetes U MotA TolQ ExbB proton channel family protein exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_132810_1 748449.Halha_2506 1.27e-171 484.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia 186801|Clostridia S domain protein - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_557955_1 345073.VC395_2654 9.19e-18 79.7 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1XSI5@135623|Vibrionales 135623|Vibrionales H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_557955_2 287.DR97_3855 1.48e-29 112.0 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,1S54H@1236|Gammaproteobacteria,1YKYC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S ATP-dependent protease La (LON) substrate-binding domain - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_852042_1 572544.Ilyop_1452 3.69e-62 200.0 COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,37909@32066|Fusobacteria 32066|Fusobacteria M Peptidase, M23 - - - - - - - - - - - - LysM,Peptidase_M23 k59_852042_2 572544.Ilyop_1449 4.6e-183 518.0 COG0821@1|root,COG0821@2|Bacteria,378T3@32066|Fusobacteria 32066|Fusobacteria H Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_852042_4 572544.Ilyop_1446 1.2e-71 219.0 COG1595@1|root,COG1595@2|Bacteria,379YV@32066|Fusobacteria 32066|Fusobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_107519_1 1319815.HMPREF0202_01787 5.46e-67 215.0 COG0489@1|root,COG0489@2|Bacteria,37BKG@32066|Fusobacteria 32066|Fusobacteria D PFAM CobQ CobB MinD ParA nucleotide binding domain - - - - - - - - - - - - AAA_31 k59_564911_1 700598.Niako_1345 8.38e-32 129.0 COG4625@1|root,COG4625@2|Bacteria,4PNU8@976|Bacteroidetes 976|Bacteroidetes S pathogenesis - - - - - - - - - - - - - k59_532529_1 926550.CLDAP_13750 7.14e-57 200.0 COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi 200795|Chloroflexi M LPXTG-motif cell wall anchor domain - - - - - - - - - - - - DUF4397 k59_695100_1 240292.Ava_2170 5.16e-30 124.0 COG1609@1|root,COG1609@2|Bacteria,1GC6P@1117|Cyanobacteria,1HM5W@1161|Nostocales 1117|Cyanobacteria K Periplasmic binding protein LacI transcriptional regulator - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_989600_1 255470.cbdbA108 8.01e-75 249.0 COG0553@1|root,COG0553@2|Bacteria,2G6I4@200795|Chloroflexi,34DJG@301297|Dehalococcoidia 301297|Dehalococcoidia L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_1022106_1 1203554.HMPREF1476_02391 1.84e-64 220.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,4PQTW@995019|Sutterellaceae 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain napA - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_400695_1 933262.AXAM01000046_gene123 4e-158 461.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MI7X@213118|Desulfobacterales 28221|Deltaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_499763_1 999411.HMPREF1092_01766 2.61e-27 108.0 COG0500@1|root,COG0500@2|Bacteria,1UIRP@1239|Firmicutes,25EQI@186801|Clostridia,36URG@31979|Clostridiaceae 186801|Clostridia Q O-methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_499763_2 694427.Palpr_0368 2.31e-72 223.0 COG3040@1|root,COG3040@2|Bacteria,4NNFA@976|Bacteroidetes,2FSTW@200643|Bacteroidia,22Y3T@171551|Porphyromonadaceae 976|Bacteroidetes M Lipocalin-like domain blc - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_663176_1 1260251.SPISAL_03255 1.32e-46 171.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_336587_1 1121918.ARWE01000001_gene3366 1.09e-93 302.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,43U3A@69541|Desulfuromonadales 28221|Deltaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding k59_695832_1 227377.CBU_0334 4.45e-28 115.0 COG0351@1|root,COG0352@1|root,COG0351@2|Bacteria,COG0352@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1JGMD@118969|Legionellales 118969|Legionellales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiDE - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K14153 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin,TMP-TENI k59_141285_1 298654.FraEuI1c_4940 3.49e-74 237.0 COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4EU9R@85013|Frankiales 201174|Actinobacteria Q NAD(P)-binding Rossmann-like domain p - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_990485_1 1294142.CINTURNW_3974 1.98e-121 371.0 COG0189@1|root,COG2918@1|root,COG0189@2|Bacteria,COG2918@2|Bacteria,1TPGX@1239|Firmicutes,25ER3@186801|Clostridia,36URU@31979|Clostridiaceae 186801|Clostridia HJ belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily gshF - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase,RimK k59_401491_2 1265505.ATUG01000001_gene4014 1.98e-69 216.0 COG0500@1|root,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,43D95@68525|delta/epsilon subdivisions,2X8FV@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q O-methyltransferase - - - - - - - - - - - - Methyltransf_2 k59_75401_1 1049564.TevJSym_ab02070 6.5e-72 225.0 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,1S9D2@1236|Gammaproteobacteria,1J6WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_75401_2 1000565.METUNv1_02828 9.69e-08 53.1 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,2KWGP@206389|Rhodocyclales 206389|Rhodocyclales S gag-polyprotein putative aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_630840_1 519441.Smon_0098 4.43e-17 82.0 COG1589@1|root,COG1589@2|Bacteria,37B09@32066|Fusobacteria 32066|Fusobacteria D Cell division protein FtsQ - - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_630840_2 1184267.A11Q_2008 3.6e-39 152.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2MSPD@213481|Bdellovibrionales,2WIQ0@28221|Deltaproteobacteria 213481|Bdellovibrionales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_760519_3 95619.PM1_0200345 2.94e-12 73.6 COG3948@1|root,COG3948@2|Bacteria,1MUFF@1224|Proteobacteria,1RNBJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S baseplate assembly protein J - - - - - - - - - - - Baseplate_J k59_760519_10 1304888.ATWF01000001_gene1590 8.88e-37 144.0 COG0616@1|root,COG0616@2|Bacteria 2|Bacteria OU serine-type peptidase activity sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_760519_11 1117314.PCIT_09474 1.39e-14 81.3 COG3500@1|root,COG3500@2|Bacteria,1MXT8@1224|Proteobacteria,1RMKC@1236|Gammaproteobacteria,2Q32W@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Phage late control gene D protein (GPD) - - - ko:K06905 - - - - ko00000 - - - Phage_GPD k59_760519_14 944547.ABLL_1885 1.8e-109 355.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,42NUQ@68525|delta/epsilon subdivisions,2YNNF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail k59_760519_17 367737.Abu_1657 1.14e-71 236.0 COG3497@1|root,COG3497@2|Bacteria,1MW1V@1224|Proteobacteria,42RUK@68525|delta/epsilon subdivisions,2YP8I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S tail sheath protein - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1 k59_760519_18 1121918.ARWE01000001_gene770 6.55e-108 338.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,43A5E@68525|delta/epsilon subdivisions,2X2KA@28221|Deltaproteobacteria,43VVQ@69541|Desulfuromonadales 28221|Deltaproteobacteria S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_760519_21 749222.Nitsa_1794 3.81e-89 296.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,42MCU@68525|delta/epsilon subdivisions,2YPN0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_760519_25 1203568.HMPREF1484_00768 6.2e-56 199.0 COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4FCD9@85020|Dermabacteraceae 201174|Actinobacteria L Participates in initiation and elongation during chromosome replication dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_760519_31 398767.Glov_0335 4.4e-24 102.0 COG2932@1|root,COG2932@2|Bacteria,1N97M@1224|Proteobacteria,42QC1@68525|delta/epsilon subdivisions,2WM0G@28221|Deltaproteobacteria 28221|Deltaproteobacteria K peptidase S24 - - - - - - - - - - - - HTH_3,Peptidase_S24,Phage_CI_repr k59_760519_34 1497679.EP56_05680 0.000162 47.0 2EI4V@1|root,33BW7@2|Bacteria,1VKQH@1239|Firmicutes,4HRPN@91061|Bacilli,26M00@186820|Listeriaceae 91061|Bacilli S Protein of unknwon function (DUF3310) - - - - - - - - - - - - DUF3310 k59_533357_1 1168034.FH5T_11850 6.68e-144 423.0 COG0034@1|root,COG0034@2|Bacteria,4NFSM@976|Bacteroidetes,2FM3Y@200643|Bacteroidia 976|Bacteroidetes F Class II glutamine amidotransferase purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7 k59_302831_1 111780.Sta7437_1985 7.16e-43 175.0 COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,3VJIW@52604|Pleurocapsales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CHASE4,GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg k59_302831_2 1211115.ALIQ01000028_gene735 9e-15 68.9 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2UG8Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_302831_3 1049564.TevJSym_ax00260 1.76e-86 262.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,1S69P@1236|Gammaproteobacteria 1236|Gammaproteobacteria K crp fnr family - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_302831_6 742735.HMPREF9467_03033 1.88e-37 150.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,21YEV@1506553|Lachnoclostridium 186801|Clostridia C Psort location Cytoplasmic, score 8.87 scfB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_302831_8 1123355.JHYO01000005_gene858 2.63e-236 685.0 COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2TZN9@28211|Alphaproteobacteria,36YYJ@31993|Methylocystaceae 28211|Alphaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 k59_302831_9 357808.RoseRS_2899 9.1e-65 211.0 COG0639@1|root,COG0639@2|Bacteria,2G71P@200795|Chloroflexi,375UU@32061|Chloroflexia 32061|Chloroflexia T PFAM metallophosphoesterase - - - - - - - - - - - - Metallophos_2 k59_302831_10 1049564.TevJSym_ap00360 1.34e-228 639.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1J4EQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUTI89_1310.UTI89_C0772,iZ_1308.Z0993 Aminotran_3 k59_302831_11 1500306.JQLA01000025_gene3392 3.09e-196 556.0 COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRD2@28211|Alphaproteobacteria,4B7WB@82115|Rhizobiaceae 28211|Alphaproteobacteria M Lytic murein transglycosylase MA20_01345 - - - - - - - - - - - PG_binding_1,SLT_2 k59_302831_12 261292.Nit79A3_0664 7.28e-60 194.0 COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,2VTM1@28216|Betaproteobacteria,371R5@32003|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family tpm - 2.1.1.67 ko:K00569 ko00983,map00983 - R08236,R08239,R08246 RC00003,RC00980,RC02277 ko00000,ko00001,ko01000 - - - TPMT k59_302831_13 1249627.D779_0215 1.3e-242 674.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1WW9J@135613|Chromatiales 135613|Chromatiales F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_925486_1 1231391.AMZF01000001_gene2867 3.48e-08 56.2 COG4929@1|root,COG4984@1|root,COG4929@2|Bacteria,COG4984@2|Bacteria,1MZW2@1224|Proteobacteria,2VKF7@28216|Betaproteobacteria,3T97W@506|Alcaligenaceae 28216|Betaproteobacteria S GDYXXLXY protein - - - - - - - - - - - - DUF2157,DUF4401,GDYXXLXY k59_925486_2 335543.Sfum_2049 6.58e-65 202.0 COG4929@1|root,COG4929@2|Bacteria,1MZW2@1224|Proteobacteria,42VIB@68525|delta/epsilon subdivisions,2WRZ9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S GDYXXLXY protein - - - - - - - - - - - - GDYXXLXY k59_826700_1 1415755.JQLV01000001_gene1661 8.14e-13 73.6 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria 1236|Gammaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) nagF - 2.7.1.202,2.7.3.9 ko:K02768,ko:K08483,ko:K11183,ko:K11189 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_1 k59_433696_1 392500.Swoo_4072 3.07e-78 239.0 COG1136@1|root,COG1136@2|Bacteria,1NHCD@1224|Proteobacteria,1RNIX@1236|Gammaproteobacteria,2QA0D@267890|Shewanellaceae 1236|Gammaproteobacteria V PFAM ABC transporter related ycfV - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_858885_2 944547.ABLL_0023 8.45e-44 154.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N5U@68525|delta/epsilon subdivisions,2YMNF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_302834_1 1232410.KI421425_gene1553 2.6e-111 345.0 COG4932@1|root,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_401500_1 484018.BACPLE_00224 3.19e-09 57.4 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,4NFUN@976|Bacteroidetes,2FNNY@200643|Bacteroidia,4ANAU@815|Bacteroidaceae 976|Bacteroidetes S Psort location CytoplasmicMembrane, score 10.00 spmA - - ko:K06373 - - - - ko00000 - - - Gate k59_401500_2 1408433.JHXV01000010_gene648 3e-12 67.4 COG2834@1|root,COG2834@2|Bacteria,4NFGN@976|Bacteroidetes,1IG54@117743|Flavobacteriia,2PBA5@246874|Cryomorphaceae 976|Bacteroidetes M outer membrane lipoprotein carrier protein LolA lolA - - ko:K03634 - - - - ko00000 - - - LolA,LolA_2 k59_40963_1 572544.Ilyop_1720 4.11e-129 386.0 COG0768@1|root,COG0768@2|Bacteria,378W3@32066|Fusobacteria 32066|Fusobacteria M penicillin-binding protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_957064_1 869213.JCM21142_72660 1.4e-81 254.0 COG1262@1|root,COG3005@1|root,COG1262@2|Bacteria,COG3005@2|Bacteria,4NEUZ@976|Bacteroidetes,47MAP@768503|Cytophagia 976|Bacteroidetes C PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - Cytochrom_NNT,FGE-sulfatase k59_108261_1 387093.SUN_0155 1.35e-169 481.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,42MYW@68525|delta/epsilon subdivisions,2YN5Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_695848_2 572544.Ilyop_1875 5.83e-41 141.0 COG2840@1|root,COG2840@2|Bacteria,37AUB@32066|Fusobacteria 32066|Fusobacteria S Smr domain - - - - - - - - - - - - Smr k59_957065_1 1121939.L861_01065 6.4e-75 234.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1XJ0T@135619|Oceanospirillales 135619|Oceanospirillales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_108264_1 3880.AES58561 5.06e-22 90.5 2E0M5@1|root,2S818@2759|Eukaryota,37X5I@33090|Viridiplantae,3GM26@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_40971_1 287.DR97_747 4.79e-91 278.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RZVB@1236|Gammaproteobacteria,1YDCY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_858897_1 749222.Nitsa_1688 1.57e-102 317.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2YMMU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_302847_1 1168034.FH5T_01095 1.11e-159 462.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia 976|Bacteroidetes E Glutamate formimidoyltransferase ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N k59_106768_1 395495.Lcho_2150 9.6e-106 316.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria,1KK3S@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_301504_1 760192.Halhy_3536 1.09e-07 56.6 COG1595@1|root,COG1595@2|Bacteria,4NMAK@976|Bacteroidetes,1ISGD@117747|Sphingobacteriia 976|Bacteroidetes K PFAM RNA polymerase sigma factor 70, region 4 type 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_498830_1 487796.Flav2ADRAFT_0050 2.98e-44 152.0 COG0052@1|root,COG0052@2|Bacteria,4NER0@976|Bacteroidetes,1HWUX@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_498830_2 945713.IALB_0699 2.6e-06 48.1 COG0264@1|root,COG0264@2|Bacteria 2|Bacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_629404_1 493475.GARC_2471 1.59e-25 101.0 COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Conserved Protein - - - - - - - - - - - - DUF1232 k59_629404_2 1265313.HRUBRA_00930 4.94e-18 82.0 COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Secreted protein, containing von Willebrand factor (VWF) type - - - - - - - - - - - - - k59_432249_2 870187.Thini_0560 8.43e-24 93.2 COG1563@1|root,COG1563@2|Bacteria,1NI59@1224|Proteobacteria 1224|Proteobacteria P Membrane bound protein complex subunit mbxD - - - - - - - - - - - - DUF4040 k59_268665_1 1127673.GLIP_2004 1.13e-11 65.5 COG0577@1|root,COG0577@2|Bacteria,1MXFC@1224|Proteobacteria,1RQX0@1236|Gammaproteobacteria,46698@72275|Alteromonadaceae 1236|Gammaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_268665_2 1535422.ND16A_3225 2.9e-26 107.0 COG0577@1|root,COG0577@2|Bacteria,1QSVW@1224|Proteobacteria,1RPBM@1236|Gammaproteobacteria,2Q64A@267889|Colwelliaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_759399_1 935837.JAEK01000019_gene755 5.02e-54 194.0 COG3250@1|root,COG4677@1|root,COG3250@2|Bacteria,COG4677@2|Bacteria,1TSCD@1239|Firmicutes,4HTSP@91061|Bacilli,1ZCC1@1386|Bacillus 91061|Bacilli G Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pec_lyase,Pectinesterase k59_759399_2 935837.JAEK01000062_gene2774 7.39e-103 305.0 COG0726@1|root,COG0726@2|Bacteria,1U0B6@1239|Firmicutes,4HE13@91061|Bacilli,1ZE23@1386|Bacillus 91061|Bacilli G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_139496_2 1232410.KI421428_gene1216 8.5e-29 102.0 COG0267@1|root,COG0267@2|Bacteria,1NJ67@1224|Proteobacteria,42V5X@68525|delta/epsilon subdivisions,2WSIR@28221|Deltaproteobacteria,43VP9@69541|Desulfuromonadales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_171781_1 314287.GB2207_07537 0.0 1110.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1J4JG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit scpA GO:0003674,GO:0003824,GO:0004494,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0019842,GO:0031419,GO:0036094,GO:0046906,GO:0048037,GO:0097159,GO:1901363 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_3653,iECO26_1355.ECO26_4004 B12-binding,MM_CoA_mutase k59_171781_2 768671.ThimaDRAFT_0549 0.0 989.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1WX2Y@135613|Chromatiales 135613|Chromatiales I synthetase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_171781_3 1163617.SCD_n02833 0.000306 49.3 COG4222@1|root,COG4222@2|Bacteria,1N0B0@1224|Proteobacteria,2VJBV@28216|Betaproteobacteria 28216|Betaproteobacteria C Esterase-like activity of phytase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - Phytase-like k59_171781_4 945713.IALB_1130 1.98e-152 461.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria 2|Bacteria C pentaerythritol trinitrate reductase activity - - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_171781_5 1049564.TevJSym_ap00490 4.01e-78 247.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1J5NF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_662350_1 29495.EA26_15615 5.68e-125 361.0 COG3039@1|root,COG3039@2|Bacteria,1Q9AW@1224|Proteobacteria,1RNU1@1236|Gammaproteobacteria,1XZ6Q@135623|Vibrionales 135623|Vibrionales L IR of VSa6 - - - - - - - - - - - - DDE_Tnp_1_3 k59_531640_1 219305.MCAG_05597 2.72e-18 90.9 COG3534@1|root,COG3534@2|Bacteria,2GP9Z@201174|Actinobacteria,4DCAS@85008|Micromonosporales 201174|Actinobacteria G Alpha-L-arabinofuranosidase C-terminus - - - - - - - - - - - - Alpha-L-AF_C,Big_3_5,CBM_4_9,DUF1349,Laminin_G_3 k59_531643_1 706587.Desti_2954 2.04e-58 199.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria,2MR2Y@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_400033_1 1123368.AUIS01000029_gene1289 1.44e-197 564.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,2NBWK@225057|Acidithiobacillales 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_301526_1 644282.Deba_1152 8.24e-55 194.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Glutamate synthase gltB1 - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_466091_1 1499685.CCFJ01000014_gene1347 6.95e-18 87.8 COG0454@1|root,COG0456@2|Bacteria,1TS4G@1239|Firmicutes,4HFDG@91061|Bacilli,1ZDFB@1386|Bacillus 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_39569_1 1278073.MYSTI_05597 1.66e-58 195.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2YWEI@29|Myxococcales 28221|Deltaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_890049_1 794903.OPIT5_05755 2.67e-50 178.0 COG0488@1|root,COG0488@2|Bacteria,46TFE@74201|Verrucomicrobia,3K7RJ@414999|Opitutae 414999|Opitutae S ABC transporter - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_268692_1 96561.Dole_3198 1.22e-84 265.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJN6@28221|Deltaproteobacteria,2MIDA@213118|Desulfobacterales 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_73742_1 572544.Ilyop_0709 1.26e-106 321.0 COG0531@1|root,COG0531@2|Bacteria,379SQ@32066|Fusobacteria 32066|Fusobacteria E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_759428_1 243090.RB3762 4.58e-107 326.0 COG0554@1|root,COG0554@2|Bacteria,2IXQW@203682|Planctomycetes 203682|Planctomycetes F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_39576_1 983548.Krodi_0732 1.11e-52 172.0 COG2209@1|root,COG2209@2|Bacteria,4NEU0@976|Bacteroidetes,1HX59@117743|Flavobacteriia,37DER@326319|Dokdonia 976|Bacteroidetes C Rnf-Nqr subunit, membrane protein nqrE - 1.6.5.8 ko:K00350 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_39576_2 1178825.ALIH01000008_gene757 7.43e-49 160.0 COG1347@1|root,COG1347@2|Bacteria,4NGD9@976|Bacteroidetes,1HXGP@117743|Flavobacteriia 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_204265_1 1122603.ATVI01000005_gene3040 3.29e-71 229.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_367979_1 1226325.HMPREF1548_00305 6.41e-58 199.0 COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,36DW7@31979|Clostridiaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit ntpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_106796_1 195253.Syn6312_0722 1.39e-275 764.0 COG3344@1|root,COG3344@2|Bacteria,1G4SU@1117|Cyanobacteria 1117|Cyanobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_890059_1 1499967.BAYZ01000131_gene344 9e-18 84.3 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_4 k59_236864_1 1304880.JAGB01000002_gene2417 6.99e-28 118.0 COG2385@1|root,COG3103@1|root,COG3807@1|root,COG2385@2|Bacteria,COG3103@2|Bacteria,COG3807@2|Bacteria,1UW6J@1239|Firmicutes 1239|Firmicutes D Spoiid lytb domain protein - - - ko:K06381 - - - - ko00000 - - - PG_binding_1,SH3_3,SpoIID,Y_Y_Y k59_564176_1 235279.HH_0362 1.5e-14 68.9 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,42SHZ@68525|delta/epsilon subdivisions,2YPDZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_564177_2 1121022.ABENE_10150 4.15e-13 66.2 2DXRU@1|root,3467H@2|Bacteria,1P347@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_759442_1 714943.Mucpa_3747 3.92e-08 59.7 COG4733@1|root,COG4733@2|Bacteria,4NTXR@976|Bacteroidetes,1IZ2D@117747|Sphingobacteriia 976|Bacteroidetes S Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - CHU_C,Laminin_G_3 k59_39594_1 273121.WS1642 7.65e-63 206.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,42NBF@68525|delta/epsilon subdivisions,2YN28@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar biosynthesis flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_825252_1 247633.GP2143_16566 3.66e-83 260.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1J4GR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J SAM-dependent methyltransferases rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_5184_1 1234364.AMSF01000060_gene975 3.14e-96 291.0 COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,1RNM4@1236|Gammaproteobacteria,1X35B@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the mandelate racemase muconate lactonizing enzyme family - - 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N k59_73765_1 572544.Ilyop_0920 1.01e-61 205.0 COG0155@1|root,COG0155@2|Bacteria,378PT@32066|Fusobacteria 32066|Fusobacteria C Nitrite sulfite reductase ferredoxin domain protein - - 1.7.7.1,1.8.1.2 ko:K00366,ko:K00381 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00858 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_73765_2 1226994.AMZB01000133_gene4844 6.43e-18 82.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1YDJP@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_498892_1 387093.SUN_2011 7.26e-65 211.0 COG0628@1|root,COG0628@2|Bacteria,1NG06@1224|Proteobacteria,42RH3@68525|delta/epsilon subdivisions 1224|Proteobacteria S Transmembrane protein 43 - - - - - - - - - - - - TMEM43 k59_759445_1 1248916.ANFY01000010_gene441 5.03e-29 121.0 COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,2U0DP@28211|Alphaproteobacteria,2K0HA@204457|Sphingomonadales 204457|Sphingomonadales G Alpha-amylase domain - - - - - - - - - - - - Alpha-amylase,Malt_amylase_C k59_268730_1 452637.Oter_2944 7.89e-57 189.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - - - - - - - - - - CN_hydrolase k59_825262_1 1385935.N836_23665 1.36e-12 72.8 COG0664@1|root,COG3264@1|root,COG0664@2|Bacteria,COG3264@2|Bacteria,1G2P9@1117|Cyanobacteria,1H843@1150|Oscillatoriales 1117|Cyanobacteria MT PFAM Mechanosensitive ion channel - - - - - - - - - - - - MS_channel,cNMP_binding k59_629478_1 177437.HRM2_02030 7.77e-66 215.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42MBY@68525|delta/epsilon subdivisions,2WIR5@28221|Deltaproteobacteria,2MISX@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Iron-containing alcohol dehydrogenase - - 1.1.1.1 ko:K00001,ko:K19954 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_791298_1 1168034.FH5T_07375 4.16e-50 166.0 COG3170@1|root,COG3170@2|Bacteria,4NF47@976|Bacteroidetes 976|Bacteroidetes NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_791298_2 1168034.FH5T_07370 5.22e-54 173.0 COG0231@1|root,COG0231@2|Bacteria,4NDXA@976|Bacteroidetes,2FP84@200643|Bacteroidia 976|Bacteroidetes J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_39610_1 335543.Sfum_1553 1.72e-125 368.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MQ8F@213462|Syntrophobacterales 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_629485_1 224308.BSU17200 3.28e-48 176.0 COG0236@1|root,COG0451@1|root,COG1020@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0451@2|Bacteria,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HTBC@91061|Bacilli,1ZS7J@1386|Bacillus 91061|Bacilli IQ polyketide synthase - - - ko:K13611,ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_236892_1 105559.Nwat_1995 9.93e-17 77.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1WWRR@135613|Chromatiales 135613|Chromatiales S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_171864_1 555779.Dthio_PD3653 2.15e-29 111.0 COG1487@1|root,COG1487@2|Bacteria,1Q93M@1224|Proteobacteria,4331D@68525|delta/epsilon subdivisions,2WYFX@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PIN domain - - - ko:K07062 - - - - ko00000,ko01000,ko02048 - - - PIN k59_596450_1 1168034.FH5T_06995 2.19e-37 139.0 COG4935@1|root,COG4935@2|Bacteria,4NGW4@976|Bacteroidetes,2FTKQ@200643|Bacteroidia 976|Bacteroidetes O Peptide-N-glycosidase F, C terminal - - - - - - - - - - - - Laminin_G_3,N-glycanase_C k59_596450_2 1168034.FH5T_07005 3.18e-91 279.0 COG0498@1|root,COG0498@2|Bacteria,4NFUZ@976|Bacteroidetes,2FQQX@200643|Bacteroidia 976|Bacteroidetes E cysteate synthase - - 2.5.1.76 ko:K15527 - - - - ko00000,ko01000 - - - PALP k59_726857_1 511062.GU3_03775 2.98e-92 278.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1Y3DX@135624|Aeromonadales 135624|Aeromonadales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_335784_1 555779.Dthio_PD1848 1.66e-69 231.0 COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,430KD@68525|delta/epsilon subdivisions,2WVSS@28221|Deltaproteobacteria 28221|Deltaproteobacteria L High confidence in function and specificity - - - - - - - - - - - - DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind k59_857752_1 1168034.FH5T_12675 6.81e-78 242.0 2CI12@1|root,338T1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_368023_1 314345.SPV1_09198 1.57e-128 374.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria 1224|Proteobacteria E Saccharopine dehydrogenase LYS1 - 1.5.1.43,1.5.1.7 ko:K00290,ko:K13746 ko00300,ko00310,ko00330,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map00330,map01100,map01110,map01130,map01230 M00030,M00032 R00715,R09079,R09080 RC00053,RC00217,RC00225,RC01532 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0902 Sacchrp_dh_C,Sacchrp_dh_NADP k59_269165_1 394503.Ccel_0667 1.82e-72 235.0 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,36E27@31979|Clostridiaceae 186801|Clostridia C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_172393_1 1168034.FH5T_06195 1.29e-78 250.0 COG0642@1|root,COG2205@2|Bacteria,4NEFW@976|Bacteroidetes,2FSEE@200643|Bacteroidia 976|Bacteroidetes T His Kinase A (phosphoacceptor) domain rprX - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_432765_1 1123033.ARNF01000083_gene1694 3.74e-39 139.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,1RP85@1236|Gammaproteobacteria,3NIIF@468|Moraxellaceae 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family liuC - 4.2.1.18,5.3.3.18 ko:K13766,ko:K15866 ko00280,ko00360,ko01100,ko01120,map00280,map00360,map01100,map01120 M00036 R02085,R09837,R09839 RC00004,RC00326,RC02416,RC02689,RC03003 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_432765_2 1100721.ALKO01000015_gene1084 2.1e-12 66.2 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,4AA5M@80864|Comamonadaceae 28216|Betaproteobacteria I Carbamoyl-phosphate synthase L chain, ATP-binding pccA - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_400399_1 987059.RBXJA2T_11907 1.95e-77 249.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2VHYV@28216|Betaproteobacteria,1KKAZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysN - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_5504_1 1168034.FH5T_14315 6.09e-143 409.0 COG3064@1|root,COG3064@2|Bacteria,4NEVD@976|Bacteroidetes,2FTFG@200643|Bacteroidia 976|Bacteroidetes M Type IX secretion system membrane protein PorP/SprF - - - - - - - - - - - - PorP_SprF k59_40001_1 1175306.GWL_41010 4.94e-126 375.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,472EJ@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_336259_1 1118153.MOY_15688 5.42e-46 161.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1XHSK@135619|Oceanospirillales 135619|Oceanospirillales J SAM-dependent - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_269172_1 1168034.FH5T_08015 1.53e-106 318.0 COG0673@1|root,COG0673@2|Bacteria,4NFMS@976|Bacteroidetes,2FQ3R@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_662896_1 1168034.FH5T_17660 7.56e-99 316.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,4NHCZ@976|Bacteroidetes,2G2X1@200643|Bacteroidia 976|Bacteroidetes S CHAT domain - - - - - - - - - - - - CHAT,TPR_12,TPR_7,TPR_8 k59_140072_1 563040.Saut_0117 1.45e-64 216.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2YN3Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_301967_1 1236976.JCM16418_1333 1.53e-41 161.0 COG2227@1|root,COG3321@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,1VS6K@1239|Firmicutes,4HTSI@91061|Bacilli,26W70@186822|Paenibacillaceae 91061|Bacilli Q Beta-ketoacyl synthase, C-terminal domain - - - ko:K13612 - - - - ko00000,ko01004,ko01008 - - - ADH_N,ADH_zinc_N,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt k59_74319_1 232346.JHQL01000003_gene653 2.27e-28 110.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1XJTV@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_368494_1 1411123.JQNH01000001_gene2097 1.77e-16 86.3 COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria 1224|Proteobacteria P ABC-type Fe3 transport system, periplasmic component - - - ko:K02012,ko:K11081 ko02010,map02010 M00190,M00302 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10,3.A.1.11.5 - - SBP_bac_6 k59_466545_1 1168067.JAGP01000001_gene33 1.81e-51 164.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,460UP@72273|Thiotrichales 72273|Thiotrichales O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_466545_2 455436.DS989813_gene1015 9.55e-64 209.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,464AJ@72275|Alteromonadaceae 1236|Gammaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_237341_1 221109.22778574 3.07e-07 55.5 COG0110@1|root,COG0110@2|Bacteria,1V7VQ@1239|Firmicutes,4HKJ5@91061|Bacilli 91061|Bacilli S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - Hexapep k59_662903_1 1168034.FH5T_20955 1.38e-68 232.0 COG1074@1|root,COG1074@2|Bacteria,4NEX4@976|Bacteroidetes,2FMHG@200643|Bacteroidia 976|Bacteroidetes L Belongs to the helicase family. UvrD subfamily addA - - - - - - - - - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C k59_400413_1 519989.ECTPHS_03672 1.87e-67 226.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales 135613|Chromatiales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_107273_1 96561.Dole_2001 6.36e-89 274.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria,2MHKG@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_890621_1 265072.Mfla_2600 8.93e-21 85.1 2A8M8@1|root,30XPN@2|Bacteria,1PJIW@1224|Proteobacteria,2W80P@28216|Betaproteobacteria,2KN7S@206350|Nitrosomonadales 206350|Nitrosomonadales - - - - - - - - - - - - - - - k59_890621_2 1049564.TevJSym_ao00540 5.6e-19 83.6 COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1J5ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S hydrolase (HAD superfamily) yrfG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_301977_1 349521.HCH_02155 8.81e-27 106.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1XHW1@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_532228_1 1168034.FH5T_20135 1.22e-123 386.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,2FQUJ@200643|Bacteroidia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_629978_1 768671.ThimaDRAFT_3051 7.06e-20 90.5 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,1RYAY@1236|Gammaproteobacteria,1WW8Z@135613|Chromatiales 135613|Chromatiales S pfam abc1 - - - - - - - - - - - - ABC1 k59_924371_1 1167006.UWK_00140 4.89e-10 55.8 COG0236@1|root,COG0236@2|Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_924371_2 1121403.AUCV01000014_gene4633 3.46e-40 143.0 COG0535@1|root,COG0535@2|Bacteria,1NDQM@1224|Proteobacteria,42YEG@68525|delta/epsilon subdivisions,2WUNR@28221|Deltaproteobacteria,2MMSQ@213118|Desulfobacterales 28221|Deltaproteobacteria S radical SAM domain protein - - - - - - - - - - - - - k59_237350_1 1122621.ATZA01000018_gene3840 9.06e-54 186.0 COG1119@1|root,COG1119@2|Bacteria,4NEWY@976|Bacteroidetes,1INTA@117747|Sphingobacteriia 976|Bacteroidetes P ABC-type molybdenum transport system ATPase component photorepair protein PhrA modF - - ko:K05776 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 - - - ABC_tran k59_596980_1 1537917.JU82_08295 6.11e-83 251.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,42MIP@68525|delta/epsilon subdivisions,2YMPW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_630365_57 768671.ThimaDRAFT_1574 1.4e-222 626.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_630365_58 156578.ATW7_03467 9.49e-61 189.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - iE2348C_1286.E2348C_3156,iPC815.YPO0906 GCV_H k59_630365_59 1249627.D779_3939 9.35e-170 484.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_630365_60 1049564.TevJSym_ak01000 1.29e-241 672.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_630365_61 768671.ThimaDRAFT_1413 5.49e-33 124.0 COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1WYR7@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0149 family - - - ko:K09895 - - - - ko00000 - - - UPF0149 k59_630365_62 697282.Mettu_1805 1.84e-15 71.6 2AP81@1|root,31E9W@2|Bacteria,1QH87@1224|Proteobacteria,1SX59@1236|Gammaproteobacteria,1XFQ7@135618|Methylococcales 135618|Methylococcales - - - - - ko:K09892 - - - - ko00000,ko03036 - - - - k59_630365_63 765912.Thimo_1192 4.96e-31 112.0 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZF3@135613|Chromatiales 135613|Chromatiales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_467157_3 1109445.AGSX01000187_gene2398 9.46e-09 56.6 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1Z0MI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S permease perM GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_565284_1 1158292.JPOE01000002_gene2607 4.94e-22 98.6 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,1KJG9@119065|unclassified Burkholderiales 28216|Betaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_565284_2 765910.MARPU_07615 2.54e-53 176.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1WW0U@135613|Chromatiales 135613|Chromatiales O HflC and HflK could regulate a protease - - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_695451_1 1408473.JHXO01000006_gene1039 6.56e-141 405.0 COG0216@1|root,COG0216@2|Bacteria,4NF72@976|Bacteroidetes,2FNKW@200643|Bacteroidia 976|Bacteroidetes J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_269784_2 990073.ATHU01000001_gene1004 1.08e-18 80.5 COG2026@1|root,COG2026@2|Bacteria,1Q1HF@1224|Proteobacteria,42XWS@68525|delta/epsilon subdivisions,2YQXE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria DJ Addiction module toxin, RelE StbE family - - - - - - - - - - - - RelE k59_140823_1 485915.Dret_1934 6.13e-76 235.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42N9Z@68525|delta/epsilon subdivisions,2WIKQ@28221|Deltaproteobacteria,2M9HW@213115|Desulfovibrionales 28221|Deltaproteobacteria I PFAM 6-phosphogluconate dehydrogenase NAD-binding - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_433315_1 1232410.KI421415_gene2942 1.04e-117 352.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,42YV6@68525|delta/epsilon subdivisions,2WTK4@28221|Deltaproteobacteria,43SVX@69541|Desulfuromonadales 28221|Deltaproteobacteria P Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_727746_1 1049564.TevJSym_an00390 7.82e-134 389.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1J4P4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSbBS512_1146.SbBS512_E3351 PGK k59_597717_2 1168034.FH5T_00095 1.88e-76 240.0 COG0681@1|root,COG0681@2|Bacteria,4NFTP@976|Bacteroidetes,2FNMS@200643|Bacteroidia 976|Bacteroidetes U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_565290_2 749222.Nitsa_1244 1.88e-47 160.0 COG1853@1|root,COG1853@2|Bacteria,1PD46@1224|Proteobacteria,42T15@68525|delta/epsilon subdivisions,2YPFK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG1853 Conserved protein domain typically associated with flavoprotein - - - - - - - - - - - - Flavin_Reduct k59_237946_1 941449.dsx2_1803 3.87e-183 539.0 COG3421@1|root,COG3421@2|Bacteria,1QVHP@1224|Proteobacteria 1224|Proteobacteria S Type III restriction enzyme, res subunit - - - - - - - - - - - - ResIII k59_205543_1 1448857.JFAP01000001_gene1258 6.77e-55 180.0 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,42MYK@68525|delta/epsilon subdivisions,2YMMB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_695461_1 713587.THITH_01990 2.03e-99 305.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_75009_1 765912.Thimo_1692 3.75e-45 162.0 COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales 135613|Chromatiales M Cell wall hydrolase autolysin - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_727756_1 1052684.PPM_2317 4.33e-57 195.0 COG2730@1|root,COG4124@1|root,COG2730@2|Bacteria,COG4124@2|Bacteria,1TSJQ@1239|Firmicutes,4HFEH@91061|Bacilli,26WFM@186822|Paenibacillaceae 1239|Firmicutes G Cellulase (glycosyl hydrolase family 5) - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Cellulase k59_75011_1 387093.SUN_2230 4.4e-20 86.7 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2YN6R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_75011_2 387093.SUN_2231 1.76e-112 323.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2YMUT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_75011_3 1165841.SULAR_07620 8.28e-66 202.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42SCR@68525|delta/epsilon subdivisions,2YP9N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_433333_1 713586.KB900536_gene1421 2.7e-71 226.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1WX9F@135613|Chromatiales 135613|Chromatiales T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_858587_1 546266.NEIMUCOT_05125 0.000579 43.1 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,2KQMA@206351|Neisseriales 206351|Neisseriales J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA gidB - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_858587_2 626887.J057_08316 3.12e-44 151.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,464DZ@72275|Alteromonadaceae 1236|Gammaproteobacteria D COG1192 ATPases involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_630401_1 378806.STAUR_3607 1.72e-113 341.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2YU3W@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_237962_1 566466.NOR53_522 5.87e-55 185.0 COG4409@1|root,COG4409@2|Bacteria,1MVUD@1224|Proteobacteria,1S95H@1236|Gammaproteobacteria 1236|Gammaproteobacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - - k59_695473_1 1123502.AQXD01000001_gene854 5.16e-66 231.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1X2XH@135614|Xanthomonadales 135614|Xanthomonadales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_107907_1 1415630.U771_14395 3.32e-17 76.6 2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria,1SGBH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2970) - - - - - - - - - - - - DUF2970 k59_107907_2 472759.Nhal_2070 9.44e-87 284.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales 135613|Chromatiales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_956625_1 1165841.SULAR_04237 2.46e-96 288.0 COG0847@1|root,COG0847@2|Bacteria,1PDD1@1224|Proteobacteria,42MUX@68525|delta/epsilon subdivisions,2YNB6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0847 DNA polymerase III epsilon subunit and related 3'-5' - - 2.7.7.7 ko:K02342,ko:K10857 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_337022_1 360911.EAT1b_0837 1.34e-79 260.0 COG3344@1|root,COG3344@2|Bacteria,1VEW8@1239|Firmicutes 1239|Firmicutes L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_40626_1 247639.MGP2080_06347 3.14e-58 196.0 COG1475@1|root,COG1475@2|Bacteria,1RIT4@1224|Proteobacteria,1SDFV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Domain of unknown function (DUF4150) - - - - - - - - - - - - DUF4150,Tox-GHH2 k59_269815_1 1319815.HMPREF0202_01787 4.26e-35 129.0 COG0489@1|root,COG0489@2|Bacteria,37BKG@32066|Fusobacteria 32066|Fusobacteria D PFAM CobQ CobB MinD ParA nucleotide binding domain - - - - - - - - - - - - AAA_31 k59_269815_2 1286171.EAL2_c18890 0.000324 43.9 COG3944@1|root,COG3944@2|Bacteria,1UZCR@1239|Firmicutes,24HS8@186801|Clostridia,25WNV@186806|Eubacteriaceae 186801|Clostridia M Chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_140854_1 525903.Taci_0765 5.37e-81 265.0 COG0481@1|root,COG0481@2|Bacteria,3TA5E@508458|Synergistetes 508458|Synergistetes M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_500208_1 1134912.AJTV01000047_gene3499 1.94e-83 276.0 COG0457@1|root,COG1413@1|root,COG3303@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,COG3303@2|Bacteria,1MX2U@1224|Proteobacteria,2TVI2@28211|Alphaproteobacteria,36ZR3@31993|Methylocystaceae 28211|Alphaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_956626_1 1537917.JU82_01550 9.82e-43 144.0 COG0716@1|root,COG0716@2|Bacteria,1QRBW@1224|Proteobacteria,43ACU@68525|delta/epsilon subdivisions,2YT0R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Low-potential electron donor to a number of redox enzymes - - - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 k59_956626_2 1537917.JU82_01555 1.77e-67 206.0 2E67S@1|root,32Q79@2|Bacteria,1N05A@1224|Proteobacteria,42X30@68525|delta/epsilon subdivisions,2YQVD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nitrogen fixation protein NifW - - - ko:K02595 - - - - ko00000 - - - NifW k59_956626_3 990073.ATHU01000001_gene1797 1.36e-51 166.0 COG0760@1|root,COG0760@2|Bacteria,1QUCX@1224|Proteobacteria,42VM2@68525|delta/epsilon subdivisions,2YQCT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O NifZ domain - - - ko:K02597 - - - - ko00000 - - - NifZ k59_956626_4 709032.Sulku_1303 2.39e-19 81.3 COG0633@1|root,COG0633@2|Bacteria,1PSR6@1224|Proteobacteria,42XGK@68525|delta/epsilon subdivisions,2YQWI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - Fer2 k59_173202_2 749222.Nitsa_0099 4.37e-51 162.0 COG0089@1|root,COG0089@2|Bacteria,1QJHM@1224|Proteobacteria,42TRQ@68525|delta/epsilon subdivisions,2YPUJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_173202_3 387093.SUN_2322 1.63e-25 99.4 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,42MPW@68525|delta/epsilon subdivisions,2YMU6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_956629_1 1415779.JOMH01000001_gene2215 9.36e-06 52.4 COG1988@1|root,COG1988@2|Bacteria,1QK5N@1224|Proteobacteria,1S0MU@1236|Gammaproteobacteria,1X507@135614|Xanthomonadales 135614|Xanthomonadales S membrane-bound metal-dependent - - - ko:K07038 - - - - ko00000 - - - YdjM k59_433345_1 926549.KI421517_gene2597 3.51e-75 244.0 COG1217@1|root,COG1217@2|Bacteria,4NDVM@976|Bacteroidetes,47KWA@768503|Cytophagia 976|Bacteroidetes T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_173626_22 765912.Thimo_3253 2.09e-66 209.0 2BDS5@1|root,327FW@2|Bacteria,1N15E@1224|Proteobacteria,1RSEH@1236|Gammaproteobacteria,1WXNG@135613|Chromatiales 135613|Chromatiales S PFAM NifQ - - - ko:K15790 - - - - ko00000 - - - NifQ k59_173626_23 159087.Daro_1447 9.47e-107 321.0 COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2VM8T@28216|Betaproteobacteria,2KVW8@206389|Rhodocyclales 206389|Rhodocyclales O ADP-ribosylglycohydrolase - - 3.2.2.24 ko:K05521 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH k59_173626_24 647113.Metok_0009 5.43e-37 132.0 COG0454@1|root,arCOG00826@2157|Archaea,2Y240@28890|Euryarchaeota,23RMS@183939|Methanococci 183939|Methanococci K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_500762_1 981327.F925_00816 1.23e-26 115.0 COG2199@1|root,COG2199@2|Bacteria,1NV1F@1224|Proteobacteria,1T2C6@1236|Gammaproteobacteria,3NKZE@468|Moraxellaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_41078_1 1349767.GJA_942 5.88e-57 203.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_892006_1 536019.Mesop_1640 7.83e-50 179.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,43HTR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_760702_1 1121405.dsmv_0987 1.28e-68 232.0 COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2MI86@213118|Desulfobacterales 28221|Deltaproteobacteria L DEAD DEAH box helicase yprA - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C,RNase_H_2 k59_75533_1 399549.Msed_2236 9.49e-21 105.0 COG1110@1|root,arCOG01526@2157|Archaea,2XPXA@28889|Crenarchaeota 28889|Crenarchaeota L Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication rgy - 3.6.4.12,5.99.1.3 ko:K03170 - - - - ko00000,ko01000,ko03032 - - - DEAD,Helicase_C,Topoisom_bac,Toprim k59_206152_2 596151.DesfrDRAFT_0716 6.02e-36 137.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MA64@213115|Desulfovibrionales 28221|Deltaproteobacteria M TIGRFAM RND efflux system, outer membrane lipoprotein, NodT - - - - - - - - - - - - OEP k59_565863_2 1123070.KB899247_gene1585 4.92e-137 400.0 COG1032@1|root,COG1032@2|Bacteria,46UQC@74201|Verrucomicrobia,2IV1I@203494|Verrucomicrobiae 203494|Verrucomicrobiae C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM k59_892009_2 1122236.KB905146_gene2003 3.73e-60 203.0 COG0702@1|root,COG0702@2|Bacteria,1MZ0C@1224|Proteobacteria,2VNMR@28216|Betaproteobacteria,2KN8P@206350|Nitrosomonadales 206350|Nitrosomonadales GM NAD(P)H-binding - - - - - - - - - - - - DoxX_3,NAD_binding_10 k59_433841_1 1229909.NSED_08780 6.19e-100 298.0 COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_565868_1 929558.SMGD1_2640 6.58e-48 176.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2YMTD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the FtsK SpoIIIE SftA family ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1022591_1 686340.Metal_0379 9.59e-78 233.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1XF2I@135618|Methylococcales 135618|Methylococcales J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_1022591_2 857087.Metme_3091 5.45e-68 228.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1XE5N@135618|Methylococcales 135618|Methylococcales C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7 k59_1022591_3 396588.Tgr7_2796 2.51e-62 194.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1WY24@135613|Chromatiales 135613|Chromatiales O redox protein, regulator of disulfide bond formation - - - ko:K07397 - - - - ko00000 - - - OsmC k59_1022591_4 768671.ThimaDRAFT_1428 1.11e-101 300.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1WX4R@135613|Chromatiales 135613|Chromatiales K PFAM Cyclic nucleotide-binding - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,HTH_Crp_2,cNMP_binding k59_1022591_6 1049564.TevJSym_ak00290 3.7e-60 189.0 COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,1S5W4@1236|Gammaproteobacteria,1J7C6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria OU NfeD-like C-terminal, partner-binding ybbJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07340 - - - - ko00000 - - - NfeD k59_1022591_7 1049564.TevJSym_ak00300 6.07e-121 356.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1J4PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0330 Membrane protease subunits, stomatin prohibitin homologs qmcA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Band_7,Band_7_C k59_1022591_8 1049564.TevJSym_ak00310 5.33e-140 399.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1J5CU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_1022591_9 2340.JV46_21950 1.48e-88 276.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1J6JM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1022591_10 1049564.TevJSym_ak00150 3.55e-176 525.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_369732_1 1158292.JPOE01000002_gene3140 2.99e-27 111.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,1KK13@119065|unclassified Burkholderiales 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_598366_1 929558.SMGD1_0764 1.47e-53 187.0 COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,42PTT@68525|delta/epsilon subdivisions,2YN20@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Zn_pept - - - - - - - - - - - - Peptidase_M14 k59_598366_2 572480.Arnit_1647 3.08e-66 219.0 COG0189@1|root,COG1555@1|root,COG0189@2|Bacteria,COG1555@2|Bacteria,1R8K6@1224|Proteobacteria,43A4Z@68525|delta/epsilon subdivisions,2YNII@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - - - - - - - - - - - HHH_3,HHH_5,RimK k59_75550_1 1408439.JHXW01000011_gene203 1.28e-68 223.0 COG0056@1|root,COG0056@2|Bacteria,378SQ@32066|Fusobacteria 32066|Fusobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_75550_2 469616.FMAG_02000 4.01e-12 65.5 COG0224@1|root,COG0224@2|Bacteria,378FI@32066|Fusobacteria 32066|Fusobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_369740_1 1121403.AUCV01000005_gene211 1.84e-34 127.0 COG1309@1|root,COG1309@2|Bacteria,1MYY2@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_369740_2 702450.CUW_1773 1.98e-28 104.0 2E3FD@1|root,32YE7@2|Bacteria,1VEE4@1239|Firmicutes,3VRNM@526524|Erysipelotrichia 526524|Erysipelotrichia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TSCPD k59_696020_2 1260251.SPISAL_01180 1e-43 160.0 COG0475@1|root,COG1226@1|root,COG3273@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,COG3273@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales 135613|Chromatiales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_728279_1 523850.TON_0785 5.18e-38 142.0 COG0469@1|root,arCOG04120@2157|Archaea,2XU34@28890|Euryarchaeota,243DH@183968|Thermococci 183968|Thermococci G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_728279_2 525897.Dbac_0136 1.33e-30 124.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2WJ7Q@28221|Deltaproteobacteria,2M8H7@213115|Desulfovibrionales 28221|Deltaproteobacteria F Cell wall formation ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_146171_3 765911.Thivi_3112 7.85e-111 322.0 COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,1SHQ0@1236|Gammaproteobacteria,1WZZ0@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390,ko:K16887 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4_17,Fer4_8 k59_146171_4 765911.Thivi_3111 3.14e-162 460.0 COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_146171_5 1439940.BAY1663_01811 1.54e-147 476.0 COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - 2.1.1.80,3.1.1.61 ko:K03320,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_146171_6 395494.Galf_1325 6.03e-108 325.0 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,44VRA@713636|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase,HTH_6,SIS k59_146171_8 1121396.KB893120_gene3073 4.75e-30 114.0 COG2940@1|root,COG2940@2|Bacteria,1RH54@1224|Proteobacteria,42YUT@68525|delta/epsilon subdivisions,2WU8Y@28221|Deltaproteobacteria,2MMK0@213118|Desulfobacterales 28221|Deltaproteobacteria S SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - - - - - - - - - - - k59_146171_9 1123401.JHYQ01000026_gene3278 1.29e-87 271.0 COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,1RQT5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_146171_10 1049564.TevJSym_ag00880 0.0 1077.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1JAJ9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Fumarate reductase flavoprotein C-term aprA - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_146176_1 1121396.KB893123_gene1076 7.87e-54 186.0 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,42PCY@68525|delta/epsilon subdivisions,2WJCR@28221|Deltaproteobacteria,2MN94@213118|Desulfobacterales 28221|Deltaproteobacteria NT Single cache domain 3 - - - ko:K03406,ko:K13487 ko02020,ko02025,ko02030,map02020,map02025,map02030 - - - ko00000,ko00001,ko02035 - - - Cache_3-Cache_2,HAMP,MCPsignal k59_242802_1 1165841.SULAR_10409 1.47e-97 293.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2YMZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_406172_1 1121939.L861_00720 7.97e-61 199.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1XIP2@135619|Oceanospirillales 135619|Oceanospirillales M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_406172_2 365044.Pnap_3418 4.43e-16 78.2 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,4ABEI@80864|Comamonadaceae 28216|Betaproteobacteria D Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_211184_1 1168034.FH5T_05340 6.07e-10 59.3 COG1284@1|root,COG1284@2|Bacteria,4NG9F@976|Bacteroidetes,2FP2N@200643|Bacteroidia 976|Bacteroidetes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2179,YitT_membrane k59_506080_1 335543.Sfum_0314 1.34e-136 398.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2MRX0@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_570177_1 502025.Hoch_3605 1.55e-25 109.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2YURF@29|Myxococcales 28221|Deltaproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_9096_1 1537917.JU82_06750 0.0 941.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2YM9V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_831347_1 929703.KE386491_gene772 6.56e-48 174.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,4NFBV@976|Bacteroidetes,47K85@768503|Cytophagia 976|Bacteroidetes EQ Hydantoinase/oxoprolinase - - 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_146194_1 237368.SCABRO_01423 2.38e-94 292.0 COG0033@1|root,COG0033@2|Bacteria,2IYG0@203682|Planctomycetes 203682|Planctomycetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_995390_1 1249627.D779_0110 1.61e-76 252.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_995390_2 396588.Tgr7_2297 7.27e-23 95.1 COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,1RQES@1236|Gammaproteobacteria,1WXQ1@135613|Chromatiales 135613|Chromatiales S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_765876_1 575590.HMPREF0156_00946 3.44e-29 117.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,4NI8S@976|Bacteroidetes 976|Bacteroidetes C NAD(P)-binding Rossmann-like domain - - 1.5.5.1 ko:K00311,ko:K00313 - - - - ko00000,ko01000 - - - DAO,ETF_QO,NAD_binding_8 k59_471387_1 526218.Sterm_0160 1.57e-44 154.0 COG0707@1|root,COG0707@2|Bacteria,378TW@32066|Fusobacteria 32066|Fusobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_897391_1 479435.Kfla_2734 9.45e-26 110.0 COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales 201174|Actinobacteria S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - DUF5122,Laminin_G_3,Malectin,PKD k59_832024_1 929558.SMGD1_2124 3.9e-72 235.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2YMYH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_9767_1 930166.CD58_27765 7.6e-76 239.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUTI89_1310.UTI89_C0772,iZ_1308.Z0993 Aminotran_3 k59_539022_2 1000565.METUNv1_02760 5.06e-21 90.5 COG3064@1|root,COG3064@2|Bacteria,1MZUF@1224|Proteobacteria,2VTY6@28216|Betaproteobacteria,2KWWH@206389|Rhodocyclales 206389|Rhodocyclales M SprA-related family - - - - - - - - - - - - SprA-related k59_795930_3 717774.Marme_4195 2.14e-150 436.0 COG3497@1|root,COG3497@2|Bacteria,1MW1V@1224|Proteobacteria,1RNUT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tail sheath protein - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_795930_6 665950.HMPREF1025_01567 3.44e-78 265.0 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,27UI5@186928|unclassified Lachnospiraceae 186801|Clostridia S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_930923_1 1150469.RSPPHO_02933 4.01e-41 144.0 COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2TQZ1@28211|Alphaproteobacteria,2JTBK@204441|Rhodospirillales 204441|Rhodospirillales S Bacterial protein of unknown function (DUF882) - - - - - - - - - - - - Peptidase_M15_2 k59_80189_1 713586.KB900536_gene2819 8.94e-106 318.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,1X28H@135613|Chromatiales 135613|Chromatiales M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_274852_1 864702.OsccyDRAFT_0931 1.36e-24 103.0 COG1235@1|root,COG1235@2|Bacteria,1G166@1117|Cyanobacteria,1H884@1150|Oscillatoriales 1117|Cyanobacteria S of the beta-lactamase superfamily I - - - - - - - - - - - - Lactamase_B_2 k59_45815_2 1232437.KL662048_gene5095 8.64e-40 133.0 COG0599@1|root,COG0599@2|Bacteria,1NBJR@1224|Proteobacteria,42SYS@68525|delta/epsilon subdivisions,2WPQD@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_766564_1 439235.Dalk_1318 1.45e-49 162.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,43BHF@68525|delta/epsilon subdivisions,2WQUJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_604161_1 742766.HMPREF9455_02340 1.1e-81 263.0 COG3408@1|root,COG5434@1|root,COG3408@2|Bacteria,COG5434@2|Bacteria,4NG9X@976|Bacteroidetes,2FP9N@200643|Bacteroidia,231SU@171551|Porphyromonadaceae 976|Bacteroidetes G Glycosyl hydrolases family 28 - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_243542_1 1232437.KL661958_gene2870 7.84e-55 194.0 COG0475@1|root,COG0569@1|root,COG1762@1|root,COG0475@2|Bacteria,COG0569@2|Bacteria,COG1762@2|Bacteria,1R9PF@1224|Proteobacteria,42RF1@68525|delta/epsilon subdivisions,2WMJJ@28221|Deltaproteobacteria,2MJ88@213118|Desulfobacterales 28221|Deltaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger,PTS_EIIA_2,TrkA_C,TrkA_N k59_1027691_1 1049564.TevJSym_ad01580 2.92e-125 390.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J4G0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_147003_2 1304880.JAGB01000003_gene1284 5.27e-30 120.0 COG2211@1|root,COG2211@2|Bacteria,1UIHN@1239|Firmicutes,25ERR@186801|Clostridia 186801|Clostridia G Major Facilitator - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_930941_1 519989.ECTPHS_00495 2.81e-95 289.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales 135613|Chromatiales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_897417_1 391625.PPSIR1_12063 4.43e-40 148.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,42PMT@68525|delta/epsilon subdivisions,2WK84@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA - 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - Fer4_10,NQRA,NQRA_SLBB k59_701473_1 886293.Sinac_0262 1.34e-30 119.0 COG1089@1|root,COG1089@2|Bacteria,2IZEA@203682|Planctomycetes 203682|Planctomycetes M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_472103_1 1123377.AUIV01000020_gene2468 4.57e-13 69.3 COG2308@1|root,COG2308@2|Bacteria,1P9A0@1224|Proteobacteria,1RYUQ@1236|Gammaproteobacteria,1X5KG@135614|Xanthomonadales 135614|Xanthomonadales S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_472103_2 338969.Rfer_0518 1.67e-101 311.0 COG3961@1|root,COG3961@2|Bacteria,1MW2F@1224|Proteobacteria,2VIQN@28216|Betaproteobacteria,4AGN2@80864|Comamonadaceae 28216|Betaproteobacteria GH Thiamine pyrophosphate enzyme, central domain ipdC - 4.1.1.74 ko:K04103 ko00380,ko01100,map00380,map01100 - R01974 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_472104_1 1265313.HRUBRA_01492 3.07e-119 347.0 COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_864252_1 326424.FRAAL0319 7.84e-40 149.0 28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_539067_1 1192034.CAP_0203 4.93e-24 105.0 COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,42SYF@68525|delta/epsilon subdivisions,2WPNQ@28221|Deltaproteobacteria,2YZZ6@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 k59_1027707_1 1223521.BBJX01000007_gene1423 7.44e-73 237.0 COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,4AGRG@80864|Comamonadaceae 28216|Betaproteobacteria IJ Formyl transferase hoxX - - ko:K19640 - - - - ko00000,ko02022 - - - ECH_1,Formyl_trans_C,Formyl_trans_N k59_147018_1 29540.C481_18900 9.34e-24 102.0 COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,23RZG@183963|Halobacteria 183963|Halobacteria E COG4608 ABC-type oligopeptide transport system, ATPase component - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_897439_1 306263.Cla_0031 0.00044 48.5 COG2378@1|root,COG2378@2|Bacteria,1R65H@1224|Proteobacteria,42PYW@68525|delta/epsilon subdivisions,2YN39@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_11,WYL k59_570961_1 498211.CJA_2794 4.58e-11 64.3 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1FG9X@10|Cellvibrio 1236|Gammaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_570961_2 1121937.AUHJ01000002_gene3539 0.000399 43.1 28Q6S@1|root,2ZCPQ@2|Bacteria,1PA2R@1224|Proteobacteria,1SUJ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_80227_1 1123377.AUIV01000001_gene916 8.96e-100 298.0 COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,1RP5T@1236|Gammaproteobacteria,1X402@135614|Xanthomonadales 135614|Xanthomonadales L Hydrolase, TatD family yjjV - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1027721_1 1121405.dsmv_0273 3.54e-43 150.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,43AEH@68525|delta/epsilon subdivisions,2WIU2@28221|Deltaproteobacteria,2MJUF@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC-2 family transporter protein yhhJ - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1027721_2 1121405.dsmv_0274 2.17e-77 235.0 COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,42Q98@68525|delta/epsilon subdivisions,2WM5S@28221|Deltaproteobacteria,2MNQ0@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2219) - - - - - - - - - - - - DUF2219 k59_179531_2 1434325.AZQN01000003_gene2520 1.08e-12 67.8 COG1879@1|root,COG1879@2|Bacteria,4NIA8@976|Bacteroidetes,47MW0@768503|Cytophagia 976|Bacteroidetes G PFAM Periplasmic binding protein LacI transcriptional regulator - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_570966_1 765911.Thivi_1422 5.03e-56 179.0 COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,1S6WS@1236|Gammaproteobacteria,1WYB2@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K04080 - - - - ko00000,ko03110 - - - HSP20 k59_897452_1 368407.Memar_1700 7.34e-15 75.1 COG0477@1|root,arCOG00130@2157|Archaea,2XWXX@28890|Euryarchaeota,2N9J6@224756|Methanomicrobia 224756|Methanomicrobia G TIGRFAM drug resistance transporter, Bcr CflA subfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_897452_2 859657.RPSI07_2632 1.74e-42 151.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,1K02G@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_832073_2 1121335.Clst_2650 4.98e-10 62.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,3WHUM@541000|Ruminococcaceae 186801|Clostridia V MacB-like periplasmic core domain macB2 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_701500_1 572480.Arnit_2468 3.83e-123 363.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42N1V@68525|delta/epsilon subdivisions,2YRFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.22,2.6.1.76 ko:K00836,ko:K07250 ko00250,ko00260,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00280,map00410,map00640,map00650,map01100,map01120,map01210,map01230 M00027,M00033 R00908,R01648,R04188,R06977 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_636662_1 1454004.AW11_01244 6.72e-132 392.0 COG3961@1|root,COG3961@2|Bacteria,1MW2F@1224|Proteobacteria,2VIQN@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the TPP enzyme family ipdC - 4.1.1.74 ko:K04103 ko00380,ko01100,map00380,map01100 - R01974 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_80248_1 869213.JCM21142_215 3.86e-30 118.0 arCOG14808@1|root,308PC@2|Bacteria,4NR4D@976|Bacteroidetes,47PEP@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 k59_308442_1 519989.ECTPHS_07267 7.46e-105 323.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_9888_1 1123401.JHYQ01000001_gene1791 1.31e-87 265.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,460HA@72273|Thiotrichales 72273|Thiotrichales EP N-terminal TM domain of oligopeptide transport permease C - - - ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1,OppC_N k59_243572_1 1206101.AZXC01000005_gene2881 1.54e-40 157.0 COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria 201174|Actinobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_832088_1 335543.Sfum_1561 7.6e-64 200.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2WIU3@28221|Deltaproteobacteria,2MQ8I@213462|Syntrophobacterales 28221|Deltaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_832088_2 56780.SYN_00992 2.8e-66 204.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2WP71@28221|Deltaproteobacteria,2MQGG@213462|Syntrophobacterales 28221|Deltaproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_832088_3 883112.HMPREF9707_00195 8.03e-17 73.9 COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,4HNUP@91061|Bacilli,27E4Z@186827|Aerococcaceae 91061|Bacilli J Belongs to the universal ribosomal protein uL29 family rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_832088_4 338966.Ppro_0689 2.11e-10 56.6 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,42TNS@68525|delta/epsilon subdivisions,2WR6G@28221|Deltaproteobacteria,43VE7@69541|Desulfuromonadales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_472133_1 1452718.JBOY01000004_gene3127 2.86e-74 238.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_45890_1 1384054.N790_04800 1.02e-95 312.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1X36Z@135614|Xanthomonadales 135614|Xanthomonadales E 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_864291_1 765913.ThidrDRAFT_0180 6.95e-94 286.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales 135613|Chromatiales U Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_343321_1 572544.Ilyop_2808 5.78e-23 107.0 28HN5@1|root,2Z7WI@2|Bacteria,37876@32066|Fusobacteria 572544.Ilyop_2808|- S Replication initiator protein A - - - - - - - - - - - - - k59_669785_1 870187.Thini_2068 1.08e-28 109.0 COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,1RMJ7@1236|Gammaproteobacteria,461BB@72273|Thiotrichales 72273|Thiotrichales M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA k59_571004_2 504487.JCM19302_4026 3.94e-21 84.7 COG1476@1|root,COG1476@2|Bacteria,4NV53@976|Bacteroidetes,1I527@117743|Flavobacteriia 976|Bacteroidetes K transcriptional regulator - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 k59_968360_2 76114.ebA3745 1.11e-18 85.9 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2VH4U@28216|Betaproteobacteria,2KX7R@206389|Rhodocyclales 206389|Rhodocyclales E Lysine 2,3-aminomutase - - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - - k59_85654_1 857087.Metme_1888 4.73e-86 280.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDW6@135618|Methylococcales 135618|Methylococcales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_642053_1 1168289.AJKI01000033_gene1288 7.49e-51 175.0 COG3385@1|root,COG3385@2|Bacteria,4NNZ7@976|Bacteroidetes,2FX02@200643|Bacteroidia,3XKN6@558415|Marinilabiliaceae 976|Bacteroidetes L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_1001494_2 349741.Amuc_2138 2.19e-61 201.0 COG0079@1|root,COG0079@2|Bacteria,46SFP@74201|Verrucomicrobia,2ITIN@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Aminotransferase class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_801367_1 545264.KB898744_gene1932 1.4e-94 300.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_512214_1 709032.Sulku_0262 2.2e-154 449.0 COG0464@1|root,COG0464@2|Bacteria,1N4ZI@1224|Proteobacteria,42NGJ@68525|delta/epsilon subdivisions,2YMAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATPase (AAA - - - - - - - - - - - - AAA k59_1001502_1 234826.AM144 2.31e-10 62.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,47FJF@766|Rickettsiales 766|Rickettsiales P once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_1001502_2 870187.Thini_1235 1.39e-37 133.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,462B7@72273|Thiotrichales 72273|Thiotrichales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes - - - - - - - - - - - - CcmB k59_576412_1 639282.DEFDS_1778 9.08e-86 283.0 COG0086@1|root,COG0086@2|Bacteria,2GETW@200930|Deferribacteres 200930|Deferribacteres K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_15363_1 990073.ATHU01000001_gene1239 2.06e-10 63.2 COG4968@1|root,COG4968@2|Bacteria,1R16A@1224|Proteobacteria,43D7T@68525|delta/epsilon subdivisions,2YTH5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl k59_15363_2 827.JFJK01000015_gene416 8.17e-14 72.0 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_217483_1 519989.ECTPHS_08101 1.22e-55 193.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria,1X2II@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_837488_1 1168034.FH5T_07470 4.94e-249 703.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,2FPM1@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family bgaA - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_544027_1 1396858.Q666_05855 1.99e-16 79.3 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,467AZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S High frequency lysogenization protein HflD homolog hflD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562 - ko:K07153 - - - - ko00000 - - - DUF489 k59_544027_2 520709.F985_01820 2.83e-15 77.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,3NJVQ@468|Moraxellaceae 1236|Gammaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_477550_2 946235.CAER01000070_gene2656 3.1e-30 120.0 COG0441@1|root,COG0441@2|Bacteria,1UHT4@1239|Firmicutes,4IS8T@91061|Bacilli,23IQG@182709|Oceanobacillus 91061|Bacilli J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_801381_1 765912.Thimo_1199 2.61e-76 248.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales 135613|Chromatiales C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_902894_1 177437.HRM2_15140 3.84e-47 159.0 COG2010@1|root,COG2010@2|Bacteria,1RDVX@1224|Proteobacteria,42WYA@68525|delta/epsilon subdivisions,2WT1Y@28221|Deltaproteobacteria,2MNSF@213118|Desulfobacterales 28221|Deltaproteobacteria C Protein of unknown function (DUF3341) - - - - - - - - - - - - DUF3341 k59_902894_2 1121405.dsmv_1663 1.94e-34 130.0 COG5557@1|root,COG5557@2|Bacteria,1QURB@1224|Proteobacteria,43BT1@68525|delta/epsilon subdivisions,2X73S@28221|Deltaproteobacteria,2MMX3@213118|Desulfobacterales 28221|Deltaproteobacteria C Pfam Polysulphide reductase, NrfD actF - - - - - - - - - - - - k59_869720_1 225849.swp_4306 1.88e-89 267.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,2QEPK@267890|Shewanellaceae 1236|Gammaproteobacteria L PFAM Integrase, catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_1001522_1 44251.PDUR_11300 8.79e-44 164.0 COG0604@1|root,COG1028@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0604@2|Bacteria,COG1028@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins - - - ko:K13612,ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_968373_1 1123247.AUIJ01000018_gene2703 2.92e-87 276.0 2DBS0@1|root,2ZANT@2|Bacteria,1R8Y3@1224|Proteobacteria,2U146@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_609487_1 572480.Arnit_2779 2.69e-208 587.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2YMWB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Biotin carboxylase pycA - 6.3.4.14,6.4.1.1,6.4.1.2 ko:K01959,ko:K01961 ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00376,M00620 R00344,R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_609487_2 1128427.KB904821_gene3492 4.01e-06 54.3 COG1994@1|root,COG1994@2|Bacteria,1G3GJ@1117|Cyanobacteria 1117|Cyanobacteria S Peptidase family M50 - - - - - - - - - - - - TPR_8 k59_642077_1 492774.JQMB01000001_gene5619 1.42e-12 75.1 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4BHCE@82115|Rhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - An_peroxidase,HCBP_related,HemolysinCabind,Peptidase_M10_C k59_15374_1 765911.Thivi_3077 4.62e-49 164.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,1WY11@135613|Chromatiales 135613|Chromatiales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_968376_1 498761.HM1_0499 2.73e-36 146.0 COG1067@1|root,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia 186801|Clostridia O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_1032945_1 765913.ThidrDRAFT_0856 5.93e-95 285.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1WWKH@135613|Chromatiales 135613|Chromatiales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_152367_1 207559.Dde_0934 3.09e-117 367.0 COG3515@1|root,COG5283@1|root,COG5412@1|root,COG3515@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,1P1DE@1224|Proteobacteria,42PIK@68525|delta/epsilon subdivisions,2WKHC@28221|Deltaproteobacteria,2M9DQ@213115|Desulfovibrionales 28221|Deltaproteobacteria S TIGRFAM Phage tail tape measure protein TP901 - - - - - - - - - - - - PhageMin_Tail k59_280176_1 1321820.HMPREF1983_00122 6.23e-33 127.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,4H9TI@91061|Bacilli,3WE42@539002|Bacillales incertae sedis 91061|Bacilli I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_280176_2 999413.HMPREF1094_04572 2.95e-26 105.0 COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,3VPH6@526524|Erysipelotrichia 526524|Erysipelotrichia E Arginosuccinate synthase argG - - - - - - - - - - - Arginosuc_synth k59_902920_1 565655.ECBG_03035 1.67e-60 196.0 COG1940@1|root,COG1940@2|Bacteria,1TQU4@1239|Firmicutes,4HA1C@91061|Bacilli,4AZ70@81852|Enterococcaceae 91061|Bacilli GK ROK family - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - ROK k59_51184_1 326298.Suden_1766 2.42e-17 75.1 2AK15@1|root,31AQQ@2|Bacteria,1Q5Z2@1224|Proteobacteria,43242@68525|delta/epsilon subdivisions,2YSUZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_51184_2 1242969.ATCC51562_1031 8.74e-83 265.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,42M8I@68525|delta/epsilon subdivisions,2YN4J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 k59_313656_2 517418.Ctha_0720 6.86e-27 101.0 COG2119@1|root,COG2119@2|Bacteria,1FFN7@1090|Chlorobi 1090|Chlorobi S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_313656_3 207559.Dde_1175 0.000458 41.2 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MGUH@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM RNA recognition motif - - - - - - - - - - - - RRM_1 k59_444627_1 653733.Selin_1522 2.19e-97 293.0 COG0019@1|root,COG0019@2|Bacteria 2|Bacteria E diaminopimelate decarboxylase activity nspC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042401,GO:0042710,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044010,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044764,GO:0045312,GO:0046204,GO:0046983,GO:0048037,GO:0050662,GO:0051704,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_DAP_Arg_deC k59_444627_2 1117647.M5M_10870 1.07e-43 160.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1J4FT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_118811_1 426114.THI_0150 1.05e-100 314.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria,1KKYF@119065|unclassified Burkholderiales 28216|Betaproteobacteria P von Willebrand factor (vWF) type A domain cbbO - - - - - - - - - - - VWA,VWA_2 k59_444638_1 1122599.AUGR01000028_gene1431 1.19e-12 68.2 COG0720@1|root,COG0720@2|Bacteria,1MXVT@1224|Proteobacteria,1RN6H@1236|Gammaproteobacteria,1XIXT@135619|Oceanospirillales 135619|Oceanospirillales H COG0720 6-pyruvoyl-tetrahydropterin synthase - - - - - - - - - - - - PTPS k59_444638_2 1123261.AXDW01000018_gene805 6.41e-32 123.0 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria,1X34T@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_280199_2 1089550.ATTH01000001_gene1662 4.77e-22 96.7 COG2503@1|root,COG2503@2|Bacteria,4NJIJ@976|Bacteroidetes,1FJA7@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S HAD superfamily, subfamily IIIB (Acid phosphatase) - - - - - - - - - - - - Acid_phosphat_B k59_249083_1 1168034.FH5T_10410 3.99e-258 755.0 COG0841@1|root,COG1131@1|root,COG0841@2|Bacteria,COG1131@2|Bacteria,4NF8M@976|Bacteroidetes,2FQY7@200643|Bacteroidia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ABC_tran,ACR_tran k59_249085_1 472759.Nhal_3945 8.39e-62 193.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1WY0Q@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_249085_2 95619.PM1_0229085 2.86e-21 91.7 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 ATP-synt_ab,ATP-synt_ab_N k59_118824_1 746697.Aeqsu_2049 6.75e-61 199.0 COG0399@1|root,COG0399@2|Bacteria,4NEBI@976|Bacteroidetes,1HWJK@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_512261_1 765910.MARPU_03780 6.52e-85 254.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1WW32@135613|Chromatiales 135613|Chromatiales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_512261_2 713586.KB900536_gene1157 1.21e-18 79.3 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1WYNJ@135613|Chromatiales 135613|Chromatiales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_675289_1 519989.ECTPHS_06227 1.4e-61 199.0 COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1WXG1@135613|Chromatiales 135613|Chromatiales S Belongs to the MtfA family - - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90 k59_675290_1 1168034.FH5T_07785 4.18e-119 347.0 COG1162@1|root,COG1162@2|Bacteria,4NE5H@976|Bacteroidetes,2FNY9@200643|Bacteroidia 976|Bacteroidetes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N k59_380130_2 572544.Ilyop_0825 3.96e-69 220.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - 2.4.1.60 ko:K07011,ko:K13005 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_2 k59_380130_3 572544.Ilyop_0825 1.23e-07 52.4 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - 2.4.1.60 ko:K07011,ko:K13005 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_2 k59_249451_1 1278307.KB907065_gene2667 3.89e-71 229.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_86204_1 1121859.KB890750_gene533 9.89e-64 206.0 COG4409@1|root,COG4409@2|Bacteria,4NFNK@976|Bacteroidetes,47JRH@768503|Cytophagia 976|Bacteroidetes G BNR repeat-like domain - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - BNR_2 k59_349165_1 1168034.FH5T_07860 2.86e-121 360.0 COG1139@1|root,COG1139@2|Bacteria,4NEBT@976|Bacteroidetes,2FP2X@200643|Bacteroidia 976|Bacteroidetes C iron-sulfur cluster-binding protein - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_544568_1 985054.JQEZ01000003_gene1066 7.54e-07 58.9 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TUKX@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - - k59_576993_1 2754.EH55_02730 3.49e-15 73.9 COG0588@1|root,COG0588@2|Bacteria,3TA2G@508458|Synergistetes 508458|Synergistetes G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_576993_2 1245471.PCA10_17480 6.81e-58 184.0 COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,1SAAN@1236|Gammaproteobacteria,1YGQ8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Cytochrome c mono- and diheme variants - - - - - - - - - - - - Cytochrom_C k59_280718_1 1254432.SCE1572_11375 4.83e-42 153.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,42N88@68525|delta/epsilon subdivisions,2WISX@28221|Deltaproteobacteria,2YU3P@29|Myxococcales 28221|Deltaproteobacteria E Serine dehydratase beta chain sdaA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_412766_1 1501230.ET33_02975 4.79e-69 219.0 COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,274FR@186822|Paenibacillaceae 91061|Bacilli C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_380579_1 926564.KI911673_gene6308 4.87e-18 83.6 COG1280@1|root,COG1280@2|Bacteria,2HRC6@201174|Actinobacteria 201174|Actinobacteria E Sap, sulfolipid-1-addressing protein - - - - - - - - - - - - SfLAP k59_707463_1 290398.Csal_2420 7.14e-103 309.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1XI36@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the citrate synthase family prpC - 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - - Citrate_synt k59_544591_1 1408473.JHXO01000002_gene3858 1.08e-94 299.0 COG3533@1|root,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes,2FN3P@200643|Bacteroidia 976|Bacteroidetes V protein conserved in bacteria - - - ko:K09955 - - - - ko00000 - - - DUF4986,Glyco_hydro_127 k59_801906_1 643562.Daes_1583 7.48e-46 154.0 293DJ@1|root,2ZQW1@2|Bacteria,1RE56@1224|Proteobacteria,42ZFY@68525|delta/epsilon subdivisions,2WUVQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_801906_2 643562.Daes_1584 4.17e-193 552.0 COG0603@1|root,COG0603@2|Bacteria,1MXFU@1224|Proteobacteria,42T68@68525|delta/epsilon subdivisions,2WS4G@28221|Deltaproteobacteria,2MC6S@213115|Desulfovibrionales 28221|Deltaproteobacteria F PP-loop superfamily ATPase - - - - - - - - - - - - QueC k59_86231_1 1150626.PHAMO_340004 1.37e-46 155.0 COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,2JST9@204441|Rhodospirillales 204441|Rhodospirillales K ROS/MUCR transcriptional regulator protein - - - - - - - - - - - - ROS_MUCR k59_642557_1 933115.GPDM_15119 3.95e-05 52.8 2EFJG@1|root,339BU@2|Bacteria,1VK1I@1239|Firmicutes,4HS8Q@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_152896_1 349521.HCH_03995 3.07e-48 159.0 2C0IR@1|root,300P8@2|Bacteria,1N4KZ@1224|Proteobacteria,1SRYZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4288) - - - - - - - - - - - - DUF4288 k59_544603_1 1049564.TevJSym_av00170 1.99e-169 485.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1J547@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616 tRNA-synt_1c k59_15895_2 935567.JAES01000016_gene1529 4.19e-07 52.4 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria,1X4UP@135614|Xanthomonadales 135614|Xanthomonadales M secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_152897_1 1502770.JQMG01000001_gene257 4.27e-64 208.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,2KM5S@206350|Nitrosomonadales 206350|Nitrosomonadales S Phosphotransferase enzyme family - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_801921_1 522306.CAP2UW1_3932 3.29e-21 93.6 COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2VIYN@28216|Betaproteobacteria 28216|Betaproteobacteria P Periplasmic copper-binding - - - ko:K07218 - - - - ko00000 - - - NosD k59_801921_2 1485544.JQKP01000002_gene1458 0.000144 44.3 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,44VAP@713636|Nitrosomonadales 28216|Betaproteobacteria K LysR substrate binding domain cbbR - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_610032_1 387093.SUN_2100 3.51e-95 306.0 COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2YSXK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I CoA enzyme activase uncharacterised domain (DUF2229) - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_642563_1 563040.Saut_1398 5.97e-49 166.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,43D3D@68525|delta/epsilon subdivisions,2YTG3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_642563_2 537970.HCAN_1299 2.77e-11 63.2 COG1286@1|root,COG1286@2|Bacteria,1NIBK@1224|Proteobacteria,42U0P@68525|delta/epsilon subdivisions,2YPS8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Colicin V production protein cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_86238_1 1279019.ARQK01000061_gene1794 3.97e-20 86.3 COG3011@1|root,COG3011@2|Bacteria,1PV30@1224|Proteobacteria,1SCCX@1236|Gammaproteobacteria,1WZJ7@135613|Chromatiales 135613|Chromatiales S Protein of unknown function, DUF393 - - - - - - - - - - - - DUF393 k59_380610_1 998674.ATTE01000001_gene499 3.48e-47 165.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,46093@72273|Thiotrichales 72273|Thiotrichales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_450877_1 1304885.AUEY01000132_gene1592 1.21e-16 84.7 COG0507@1|root,COG0507@2|Bacteria,1MUTR@1224|Proteobacteria,42NEY@68525|delta/epsilon subdivisions,2WU9R@28221|Deltaproteobacteria,2MNP1@213118|Desulfobacterales 28221|Deltaproteobacteria L MobA/MobL family traA - - - - - - - - - - - AAA_30,MobA_MobL,TrwC k59_1006891_2 709032.Sulku_2377 1.82e-22 96.3 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2YN3Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_318941_1 59689.fgenesh1_pm.C_scaffold_2000596 2.04e-16 74.7 COG0091@1|root,KOG1711@2759|Eukaryota,37WS8@33090|Viridiplantae,3GJJC@35493|Streptophyta 35493|Streptophyta J 50S ribosomal protein L22, chloroplastic rpl22 GO:0000313,GO:0000315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0015934,GO:0031967,GO:0031974,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0098798,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_875401_1 387093.SUN_1782 2.46e-95 288.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2YMGX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_582479_1 1278073.MYSTI_00851 8.57e-30 122.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42QKW@68525|delta/epsilon subdivisions,2WKH1@28221|Deltaproteobacteria,2YWTQ@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_743718_2 2340.JV46_04100 4.02e-07 52.4 COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,1S9YH@1236|Gammaproteobacteria,1J6NP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA hscB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04082 - - - - ko00000,ko03029,ko03110 - - - DnaJ,HSCB_C k59_254706_2 610130.Closa_3329 1.47e-137 395.0 COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,2487W@186801|Clostridia,2213B@1506553|Lachnoclostridium 186801|Clostridia L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_21,rve,rve_2 k59_254706_3 887929.HMP0721_2492 3.82e-67 211.0 COG2963@1|root,COG2963@2|Bacteria,1V09A@1239|Firmicutes,24G3Z@186801|Clostridia,25ZDZ@186806|Eubacteriaceae 186801|Clostridia L Helix-turn-helix domain - - - - - - - - - - - - HTH_28 k59_1039913_2 1255043.TVNIR_2412 1.19e-63 206.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1WZEX@135613|Chromatiales 135613|Chromatiales H DinB superfamily - - 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - DinB_2,FGE-sulfatase k59_942473_1 243159.AFE_1655 3.22e-90 270.0 COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,1RY10@1236|Gammaproteobacteria,2NCKJ@225057|Acidithiobacillales 225057|Acidithiobacillales L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_28,HTH_33 k59_57817_1 1168034.FH5T_20305 1.93e-29 116.0 COG0739@1|root,COG0739@2|Bacteria,4NED7@976|Bacteroidetes,2FP3N@200643|Bacteroidia 976|Bacteroidetes M Peptidase, M23 family - - - - - - - - - - - - Peptidase_M23 k59_418305_1 880072.Desac_0499 2.6e-105 317.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales 28221|Deltaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_22025_1 1168034.FH5T_08845 4.3e-163 490.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FRGY@200643|Bacteroidia 976|Bacteroidetes V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_583130_1 746697.Aeqsu_1361 1.14e-106 313.0 COG0115@1|root,COG0115@2|Bacteria,4NI83@976|Bacteroidetes,1HZ20@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_223675_1 572544.Ilyop_0577 3.82e-173 508.0 COG0466@1|root,COG0466@2|Bacteria,3789S@32066|Fusobacteria 32066|Fusobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_942477_1 1226994.AMZB01000132_gene4880 9.07e-21 92.4 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1YEE5@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Domain of unknown function (DUF4478) ygdH GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464,GO:0047405 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_942477_2 1294273.roselon_00985 2.55e-23 94.4 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,2TS2U@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD k59_713300_1 1537917.JU82_05045 1.73e-98 302.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,42P71@68525|delta/epsilon subdivisions,2YNAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Phospholipid glycerol acyltransferase - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_807624_1 1123368.AUIS01000019_gene1205 2.06e-36 134.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_418310_1 471852.Tcur_4392 1.21e-10 61.6 COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,4EH97@85012|Streptosporangiales 201174|Actinobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_418310_2 500153.JOEK01000005_gene2180 1.36e-60 205.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria 201174|Actinobacteria C Ferredoxin oxidoreductase korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_550758_2 65071.PYU1_T014948 4.81e-16 78.6 COG1028@1|root,KOG1611@2759|Eukaryota 2759|Eukaryota IQ cellular detoxification of aldehyde - - - - - - - - - - - - adh_short k59_713309_1 269798.CHU_1255 2.66e-92 282.0 COG0683@1|root,COG0683@2|Bacteria 2|Bacteria E ABC-type branched-chain amino acid transport systems, periplasmic component urtA - - ko:K01999,ko:K11959 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - iJN678.amiC Peripla_BP_5 k59_550760_1 1122225.AULQ01000001_gene1947 5.31e-08 59.7 COG1361@1|root,COG2304@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG4932@2|Bacteria,4NMB8@976|Bacteroidetes,1IJKA@117743|Flavobacteriia 976|Bacteroidetes M Pfam C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,Calx-beta,DUF11,HYR,SdrD_B k59_1007608_3 1163408.UU9_03358 2.87e-14 71.6 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1X32H@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the peptidase S33 family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_807634_1 1120951.AUBG01000007_gene238 2.29e-100 298.0 COG0300@1|root,COG0300@2|Bacteria,4NGDI@976|Bacteroidetes,1HXR7@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_451708_1 448385.sce4090 0.000302 45.8 COG2114@1|root,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,43F3X@68525|delta/epsilon subdivisions,2X3BR@28221|Deltaproteobacteria,2YVB1@29|Myxococcales 28221|Deltaproteobacteria T Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - - - - - - - - - - - Guanylate_cyc k59_287071_1 420662.Mpe_A1507 3.08e-44 155.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VJ0T@28216|Betaproteobacteria,1KITT@119065|unclassified Burkholderiales 28216|Betaproteobacteria BQ Histone deacetylase domain acuC - - - - - - - - - - - Hist_deacetyl k59_354625_1 1049564.TevJSym_au00280 1.32e-05 44.7 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,1J6K6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_354625_2 1266914.ATUK01000012_gene151 2.67e-62 212.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_483128_1 1123519.PSJM300_00205 4.69e-69 223.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1Z0WQ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_778680_1 709032.Sulku_1497 8.36e-122 361.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,42MNG@68525|delta/epsilon subdivisions,2YNM4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation - - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_387201_1 929558.SMGD1_2568 4.1e-26 100.0 COG0818@1|root,COG0818@2|Bacteria,1Q5TS@1224|Proteobacteria,42SZA@68525|delta/epsilon subdivisions,2YSYV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Recycling of diacylglycerol produced during the turnover of membrane phospholipid - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_387201_2 1249480.B649_05735 1.08e-22 95.5 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2YM99@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Saccharopine dehydrogenase LYS1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_1039950_1 1121875.KB907546_gene2210 3.02e-13 70.1 COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia 976|Bacteroidetes Q Imidazolonepropionase and related - - - - - - - - - - - - Amidohydro_1 k59_1039950_2 504487.JCM19302_3553 8.86e-82 254.0 COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia 976|Bacteroidetes Q Imidazolonepropionase and related - - - - - - - - - - - - Amidohydro_1 k59_648677_1 1265310.CCBD010000050_gene1878 5.54e-05 45.4 COG1028@1|root,COG2072@1|root,COG1028@2|Bacteria,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,233PF@1762|Mycobacteriaceae 201174|Actinobacteria P Flavoprotein involved in K transport - - - - - - - - - - - - FMO-like,K_oxygenase,Pyr_redox_3 k59_125334_1 1408439.JHXW01000007_gene9 2.12e-178 507.0 COG1775@1|root,COG1775@2|Bacteria,378CI@32066|Fusobacteria 32066|Fusobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component fldB - 4.2.1.167 ko:K20903 - - - - ko00000,ko01000 - - - HGD-D k59_125334_2 1408439.JHXW01000007_gene8 2.54e-69 221.0 COG1775@1|root,COG1775@2|Bacteria,378XN@32066|Fusobacteria 32066|Fusobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component hgdB - 4.2.1.167 ko:K20904 - - - - ko00000,ko01000 - - - HGD-D k59_778693_1 1168034.FH5T_16490 3.24e-136 393.0 COG0674@1|root,COG0674@2|Bacteria,4NGYK@976|Bacteroidetes,2FM6R@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA vorB - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_583168_1 1437824.BN940_04161 1.07e-53 177.0 COG4790@1|root,COG4790@2|Bacteria,1R34E@1224|Proteobacteria,2VQWC@28216|Betaproteobacteria,3T394@506|Alcaligenaceae 28216|Betaproteobacteria U Part of a set of proteins involved in the infection of eukaryotic cells bscR - - ko:K03226 ko03070,map03070 M00332,M00542,M00660 - - ko00000,ko00001,ko00002,ko02044 3.A.6.1,3.A.6.3 - - FliP k59_1039953_2 1105367.CG50_11660 4.72e-95 280.0 COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2TRMB@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Nicotinamidase pncA - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase k59_876212_1 686340.Metal_3281 2.66e-33 129.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1XES6@135618|Methylococcales 135618|Methylococcales K ribonuclease BN - - - ko:K07058 - - - - ko00000 - - - Rrf2,Virul_fac_BrkB k59_451746_1 1118235.CAJH01000030_gene2070 1.35e-30 111.0 COG3052@1|root,COG3052@2|Bacteria,1N71C@1224|Proteobacteria,1SG3Y@1236|Gammaproteobacteria,1X8BD@135614|Xanthomonadales 135614|Xanthomonadales C Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism mdcC - - ko:K13931 - - - - ko00000,ko02000 3.B.1.1.4 - - ACP k59_451746_2 375286.mma_0106 3.82e-71 223.0 COG4799@1|root,COG4799@2|Bacteria,1PDNC@1224|Proteobacteria,2VIGW@28216|Betaproteobacteria,472R2@75682|Oxalobacteraceae 28216|Betaproteobacteria I beta subunit mdcD - 4.1.1.87 ko:K13932 - - - - ko00000,ko01000 - - - Carboxyl_trans k59_22081_1 1118153.MOY_16447 1.59e-14 68.6 COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,1S6RG@1236|Gammaproteobacteria,1XS92@135619|Oceanospirillales 135619|Oceanospirillales L COG2963 Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_22081_2 745776.DGo_PC0249 1.31e-07 52.0 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_92571_1 1469607.KK073768_gene728 2.55e-77 254.0 COG3039@1|root,COG3039@2|Bacteria,1G3YX@1117|Cyanobacteria,1HQJP@1161|Nostocales 1117|Cyanobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_2,DUF772 k59_191420_1 313628.LNTAR_20638 7.13e-119 356.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_418358_1 298654.FraEuI1c_2131 2.98e-44 158.0 COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4EUTF@85013|Frankiales 201174|Actinobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 k59_451763_1 34506.g2356 2.23e-55 193.0 COG0294@1|root,COG1109@1|root,KOG1220@2759|Eukaryota,KOG2544@2759|Eukaryota,38WEB@33154|Opisthokonta,3C72M@33208|Metazoa,3DRE6@33213|Bilateria,40P6G@6231|Nematoda,1M6NG@119089|Chromadorea,4152Z@6236|Rhabditida 33208|Metazoa G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II - - - - - - - - - - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III k59_583181_1 1249480.B649_09220 1.12e-140 419.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2YMF5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent CLP protease ATP-binding subunit clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_648696_1 243231.GSU3073 1.42e-31 125.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2WIJZ@28221|Deltaproteobacteria,43TX6@69541|Desulfuromonadales 28221|Deltaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_681640_1 1385520.N802_01640 1.57e-53 172.0 2DZGK@1|root,32VA1@2|Bacteria,2IJIB@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - PDDEXK_5 k59_942545_1 927658.AJUM01000016_gene3146 2.28e-10 65.9 COG2356@1|root,COG2356@2|Bacteria,4NEGS@976|Bacteroidetes,2FPB5@200643|Bacteroidia,3XJ1B@558415|Marinilabiliaceae 976|Bacteroidetes L Endonuclease I - - - - - - - - - - - - Endonuclease_1,LTD,fn3 k59_255571_2 683083.C414_000350084 2.42e-13 71.2 COG3562@1|root,COG3562@2|Bacteria,1MUZT@1224|Proteobacteria,42P5Z@68525|delta/epsilon subdivisions,2YMNP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Capsule polysaccharide biosynthesis protein kpsS - - ko:K07265 - - - - ko00000 - - - Capsule_synth k59_287095_1 563040.Saut_0592 5.74e-58 203.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2YMGZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_974561_1 187272.Mlg_1127 6.15e-59 186.0 COG1765@1|root,COG1765@2|Bacteria,1R9XU@1224|Proteobacteria,1SB92@1236|Gammaproteobacteria,1X0XT@135613|Chromatiales 135613|Chromatiales O OsmC-like protein - - - - - - - - - - - - OsmC k59_57926_1 102107.XP_008224000.1 1.71e-130 420.0 28JZI@1|root,2QSDY@2759|Eukaryota,37J4T@33090|Viridiplantae,3GC2Z@35493|Streptophyta,4JREA@91835|fabids 35493|Streptophyta U Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope ycf1 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009507,GO:0009526,GO:0009528,GO:0009536,GO:0009706,GO:0009941,GO:0015031,GO:0015833,GO:0016020,GO:0019866,GO:0031090,GO:0031967,GO:0031969,GO:0031975,GO:0033036,GO:0042170,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - - - - - - - - - - Ycf1 k59_615901_1 1218084.BBJK01000149_gene7523 1.95e-18 84.7 COG1075@1|root,COG1075@2|Bacteria,1NSK3@1224|Proteobacteria,2WG1G@28216|Betaproteobacteria,1KI8H@119060|Burkholderiaceae 28216|Betaproteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_615901_2 266264.Rmet_5216 4.73e-21 93.2 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WBWX@28216|Betaproteobacteria,1K6U7@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_648702_2 1122599.AUGR01000005_gene1835 1.19e-19 89.4 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RN7K@1236|Gammaproteobacteria,1XR9V@135619|Oceanospirillales 135619|Oceanospirillales K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_125383_1 642492.Clole_3818 3.55e-42 155.0 COG3307@1|root,COG3307@2|Bacteria,1U3ZF@1239|Firmicutes,249D2@186801|Clostridia 186801|Clostridia M O-antigen - - - - - - - - - - - - Wzy_C k59_125383_2 748449.Halha_1493 4.38e-129 409.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3WBD0@53433|Halanaerobiales 186801|Clostridia E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_191440_1 335541.Swol_1472 4.16e-31 117.0 COG1120@1|root,COG1120@2|Bacteria,1UYT8@1239|Firmicutes,24CJY@186801|Clostridia,42KYN@68298|Syntrophomonadaceae 186801|Clostridia P ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_191440_2 335541.Swol_1473 2.2e-126 369.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,42JXY@68298|Syntrophomonadaceae 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_550865_1 439235.Dalk_4043 6.93e-79 260.0 COG0515@1|root,COG3829@1|root,COG0515@2|Bacteria,COG3829@2|Bacteria,1N4M6@1224|Proteobacteria,42M38@68525|delta/epsilon subdivisions,2WIR0@28221|Deltaproteobacteria,2MJ85@213118|Desulfobacterales 28221|Deltaproteobacteria T sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - GAF_2,HTH_8,PAS_3,PAS_4,PAS_9,Sigma54_activat k59_387270_1 1165841.SULAR_09614 4.65e-136 397.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2YNCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_681653_2 1123073.KB899242_gene1451 3.29e-143 424.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1X5RA@135614|Xanthomonadales 135614|Xanthomonadales Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_550868_1 232721.Ajs_1844 1.59e-94 283.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,4AEQ3@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Integrase catalytic - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_778712_1 1392488.JHZY01000004_gene3642 2.36e-76 246.0 COG2304@1|root,COG2304@2|Bacteria,4NFX3@976|Bacteroidetes,1HY6K@117743|Flavobacteriia 976|Bacteroidetes M von Willebrand factor, type A yfbK - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - CarbopepD_reg_2,DUF3520,Plug,TSP_3,VWA,vWF_A k59_615910_1 880072.Desac_0388 2.6e-34 134.0 COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,42N4N@68525|delta/epsilon subdivisions,2WKJ1@28221|Deltaproteobacteria 28221|Deltaproteobacteria T metal-dependent phosphohydrolase HD region - - - - - - - - - - - - GAF,HD,HD_5 k59_92592_1 1348635.BBJY01000004_gene3105 1.56e-24 97.4 COG0564@1|root,COG0564@2|Bacteria,1RDAG@1224|Proteobacteria,1S406@1236|Gammaproteobacteria,1XVCV@135623|Vibrionales 135623|Vibrionales J COG0564 Pseudouridylate synthases, 23S RNA-specific - - 5.4.99.28,5.4.99.29 ko:K06177 - - - - ko00000,ko01000,ko03009,ko03016 - - - PseudoU_synth_2 k59_92592_2 1348635.BBJY01000004_gene3106 5.49e-88 265.0 COG1092@1|root,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria,1RN8N@1236|Gammaproteobacteria,1XTCF@135623|Vibrionales 135623|Vibrionales J Belongs to the methyltransferase superfamily - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_713395_1 102107.XP_008237697.1 6.5e-33 121.0 COG0526@1|root,KOG0910@2759|Eukaryota,37U0I@33090|Viridiplantae,3GIAN@35493|Streptophyta,4JPWB@91835|fabids 35493|Streptophyta O Thioredoxin - GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009507,GO:0009536,GO:0009636,GO:0009657,GO:0009987,GO:0015035,GO:0015036,GO:0016043,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0016999,GO:0017001,GO:0017144,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0042737,GO:0042743,GO:0042744,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071840,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_97886_1 525898.Sdel_0857 1.63e-114 393.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - Hint_2 k59_980471_1 746697.Aeqsu_0888 2.08e-97 305.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,4NFUJ@976|Bacteroidetes,1HXS7@117743|Flavobacteriia 976|Bacteroidetes C Malic enzyme maeB - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_488830_1 1449976.KALB_2946 1.98e-21 98.6 COG1881@1|root,COG2133@1|root,COG1881@2|Bacteria,COG2133@2|Bacteria,2GISM@201174|Actinobacteria,4E1H5@85010|Pseudonocardiales 201174|Actinobacteria G Carbohydrate binding module (family 35) - - - - - - - - - - - - CBM_35,CBM_6,GSDH,PBP,fn3 k59_784304_1 1121920.AUAU01000007_gene506 3.14e-13 70.5 COG0477@1|root,COG2814@2|Bacteria,3Y6YQ@57723|Acidobacteria 57723|Acidobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_784304_2 399739.Pmen_2011 2.19e-39 143.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,1YG50@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Glutamine amidotransferase - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_914728_1 749222.Nitsa_0904 1.7e-61 199.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2YN32@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_488835_1 326298.Suden_1777 5.63e-53 177.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2YMJU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_488835_2 1123326.JFBL01000008_gene528 1.28e-06 48.5 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2YMW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Alkyl hydroperoxide reductase ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_27383_1 1008457.BAEX01000039_gene2874 0.000288 47.8 COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,4NDUK@976|Bacteroidetes,1HX0V@117743|Flavobacteriia,47IQR@76831|Myroides 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_784306_1 933262.AXAM01000034_gene1559 1.87e-97 302.0 COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales 28221|Deltaproteobacteria T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - - - - - - - - - - - k59_261360_1 593907.Celgi_0672 8.66e-92 283.0 COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,4F0EF@85016|Cellulomonadaceae 201174|Actinobacteria T SMART Nucleotide binding protein PINc phoH2 - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_881566_1 232346.JHQL01000004_gene1732 7.12e-33 127.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1XICE@135619|Oceanospirillales 135619|Oceanospirillales M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_488848_1 1168034.FH5T_18125 6.37e-111 335.0 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - - - - - - - - - - PQQ_2 k59_261365_1 1089553.Tph_c21680 2.71e-49 178.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.17.1.10,1.17.1.9,1.97.1.9 ko:K00123,ko:K12527,ko:K15022 ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519,R07229 RC02420,RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3 k59_848990_1 1537917.JU82_04790 2.26e-110 330.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2YMUS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the CinA family cinA - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_750203_1 326298.Suden_0373 1.17e-67 215.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,42MBW@68525|delta/epsilon subdivisions,2YMVQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ribonuclease BN rbn - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_750203_2 929558.SMGD1_0873 8.98e-225 627.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2YMAY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Glycolate oxidase subunit glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_97940_1 765914.ThisiDRAFT_1546 3.8e-68 215.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1WY0S@135613|Chromatiales 135613|Chromatiales O PFAM 20S proteasome, A and B subunits - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_27411_1 722419.PH505_fb00010 7.35e-51 177.0 COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,1RN0A@1236|Gammaproteobacteria,2Q3VH@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_424026_1 1265505.ATUG01000002_gene1362 1.12e-37 147.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MJGP@213118|Desulfobacterales 28221|Deltaproteobacteria BQ PFAM Histone deacetylase - - - - - - - - - - - - Hist_deacetyl k59_1013092_1 1268239.PALB_24730 2.72e-58 196.0 COG3724@1|root,COG3724@2|Bacteria,1MUJV@1224|Proteobacteria,1RNSS@1236|Gammaproteobacteria,2PZE7@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) astB GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008150,GO:0008152,GO:0009015,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.3.23 ko:K01484 ko00330,ko01100,map00330,map01100 - R04189 RC00024 ko00000,ko00001,ko01000 - - iECH74115_1262.ECH74115_2463,iECSP_1301.ECSP_2313,iECs_1301.ECs2451,iG2583_1286.G2583_2191 AstB k59_292616_1 1121403.AUCV01000016_gene4416 9.2e-51 166.0 COG0834@1|root,COG0834@2|Bacteria,1RHMR@1224|Proteobacteria,42TGV@68525|delta/epsilon subdivisions,2WQZJ@28221|Deltaproteobacteria,2MKSF@213118|Desulfobacterales 28221|Deltaproteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - - - - - - - - - - - k59_750209_2 1336233.JAEH01000046_gene3789 1.08e-10 62.8 COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,1RZYZ@1236|Gammaproteobacteria,2QATI@267890|Shewanellaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_424028_1 927658.AJUM01000034_gene89 3.74e-76 237.0 2ACWU@1|root,312I8@2|Bacteria,4PHHH@976|Bacteroidetes,2G1D3@200643|Bacteroidia,3XKVE@558415|Marinilabiliaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_261383_1 469615.FGAG_00109 2.58e-54 187.0 COG0606@1|root,COG0606@2|Bacteria,3787A@32066|Fusobacteria 32066|Fusobacteria O Psort location Cytoplasmic, score - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_848995_2 1519464.HY22_07965 3.14e-53 185.0 COG0209@1|root,COG0209@2|Bacteria 2|Bacteria F ribonucleoside-diphosphate reductase activity rtpR - 1.1.98.6,1.17.4.1 ko:K00525,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC k59_814003_1 1319815.HMPREF0202_01207 2.76e-08 60.8 COG1074@1|root,COG1074@2|Bacteria,3783I@32066|Fusobacteria 32066|Fusobacteria L Belongs to the helicase family. UvrD subfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_980525_1 526222.Desal_3048 2.82e-22 97.1 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,2M9JT@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_980525_2 525897.Dbac_2362 1.15e-22 97.1 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MG2T@213115|Desulfovibrionales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_292632_1 1168034.FH5T_11140 3.45e-77 242.0 COG0477@1|root,COG2814@2|Bacteria,4NMJE@976|Bacteroidetes 976|Bacteroidetes EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_914767_1 360107.CHAB381_1565 3.26e-15 75.9 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_914767_2 32024.JMTI01000002_gene687 1.61e-17 81.6 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_914767_3 749222.Nitsa_2030 2.21e-19 85.5 COG2165@1|root,COG2165@2|Bacteria,1QUIP@1224|Proteobacteria,42VHZ@68525|delta/epsilon subdivisions,2YQA3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU TIGRFAM prepilin-type N-terminal cleavage methylation domain - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_27443_1 319224.Sputcn32_1704 3.71e-35 132.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,2QA8V@267890|Shewanellaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_27443_2 402881.Plav_0175 4.65e-47 170.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JN93@119043|Rhodobiaceae 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_980553_1 1121033.AUCF01000005_gene5095 5.02e-89 281.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2TQVI@28211|Alphaproteobacteria,2JQXC@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_849017_2 105559.Nwat_1252 9.42e-88 268.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1WX0B@135613|Chromatiales 135613|Chromatiales O heat shock protein DnaJ - - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_814026_1 768671.ThimaDRAFT_1325 3.01e-93 288.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria,1X080@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_881650_1 929558.SMGD1_0424 1.09e-73 247.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,42M05@68525|delta/epsilon subdivisions,2YNMZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Bacterial NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_784382_1 1197719.A464_4485 0.000184 50.4 COG4227@1|root,COG4227@2|Bacteria,1MU8I@1224|Proteobacteria,1RNU7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Antirestriction protein traC - - - - - - - - - - - DUF1738,Toprim_4 k59_98004_2 1291050.JAGE01000001_gene1471 2.71e-97 304.0 COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,3WHD2@541000|Ruminococcaceae 186801|Clostridia J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_784398_1 1168034.FH5T_21225 3.28e-83 263.0 COG0659@1|root,COG0659@2|Bacteria,4NF1C@976|Bacteroidetes,2FPEW@200643|Bacteroidia 976|Bacteroidetes P Sulfate permease sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_325523_1 1449346.JQMO01000003_gene4557 2.2e-106 327.0 COG0210@1|root,COG0210@2|Bacteria 2|Bacteria L ATP-dependent DNA helicase activity - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C k59_881672_1 1530085.A0A077K814_9CAUD 2.47e-93 282.0 4QBAD@10239|Viruses,4QPAI@28883|Caudovirales,4QK7N@10662|Myoviridae 10662|Myoviridae S Transposase domain (DUF772) - - - - - - - - - - - - - k59_292665_2 1123053.AUDG01000031_gene952 0.000124 48.9 COG1262@1|root,COG1520@1|root,COG2931@1|root,COG3209@1|root,COG1262@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,1QX0G@1224|Proteobacteria,1T32B@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - - k59_980607_1 102232.GLO73106DRAFT_00001680 1.68e-15 72.0 COG5304@1|root,COG5304@2|Bacteria,1G88G@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_980607_2 91464.S7335_2051 4.37e-17 81.3 COG1640@1|root,COG1640@2|Bacteria,1G0F2@1117|Cyanobacteria,1GYH4@1129|Synechococcus 1117|Cyanobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 iJN678.malQ Glyco_hydro_77 k59_292673_1 2340.JV46_04790 4.44e-06 53.9 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5FS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V MacB-like periplasmic core domain VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_980615_1 1286632.P278_09360 2.94e-51 181.0 COG0526@1|root,COG0526@2|Bacteria,4NKFI@976|Bacteroidetes,1HZXV@117743|Flavobacteriia 976|Bacteroidetes CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,DUF4369 k59_424109_1 118166.JH976537_gene4619 7.9e-67 213.0 COG1234@1|root,COG1234@2|Bacteria 2|Bacteria L tRNA 3'-trailer cleavage - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_881679_1 1304866.K413DRAFT_2250 4.39e-38 139.0 COG4225@1|root,COG4225@2|Bacteria,1TRJ7@1239|Firmicutes,24806@186801|Clostridia,36FJQ@31979|Clostridiaceae 186801|Clostridia S PFAM Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_196329_1 1265505.ATUG01000002_gene2693 6.79e-34 135.0 COG3072@1|root,COG3072@2|Bacteria,1P6F9@1224|Proteobacteria,42QB4@68525|delta/epsilon subdivisions,2WM0I@28221|Deltaproteobacteria,2MJA0@213118|Desulfobacterales 28221|Deltaproteobacteria F Adenylate cyclase NT domain - - - - - - - - - - - - Adenyl_cycl_N,Adenylate_cycl k59_621306_1 296591.Bpro_0886 2.58e-52 172.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,4AAD1@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_915486_1 1504981.KO116_3904 4.77e-44 163.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria,1XRKY@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_588644_2 519989.ECTPHS_03026 3.95e-36 133.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1WWRB@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_752067_1 177437.HRM2_09570 4.22e-122 354.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,42RAQ@68525|delta/epsilon subdivisions,2WMQN@28221|Deltaproteobacteria,2MJK9@213118|Desulfobacterales 28221|Deltaproteobacteria G Haloacid dehalogenase-like hydrolase - - 3.1.3.41 ko:K01101,ko:K02566 ko00627,ko01120,map00627,map01120 - R03024 RC00151 ko00000,ko00001,ko01000 - - - Hydrolase_6,Hydrolase_like k59_980845_1 709032.Sulku_0580 2.25e-187 535.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,42M6T@68525|delta/epsilon subdivisions,2YMJD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_294401_1 484770.UFO1_0996 1.87e-108 325.0 COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,4H2IF@909932|Negativicutes 909932|Negativicutes E diaminopimelate decarboxylase lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_621314_2 1177179.A11A3_08165 4.91e-63 208.0 COG2911@1|root,COG2911@2|Bacteria,1NHQB@1224|Proteobacteria,1SVEG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_2 k59_425163_1 933262.AXAM01000013_gene1293 4.06e-83 258.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2MHTR@213118|Desulfobacterales 28221|Deltaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_163667_1 572544.Ilyop_1737 1.28e-91 288.0 COG1080@1|root,COG1080@2|Bacteria,379N8@32066|Fusobacteria 32066|Fusobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_523237_2 889378.Spiaf_1115 4.08e-17 91.3 COG4097@1|root,COG4097@2|Bacteria,2JAX7@203691|Spirochaetes 203691|Spirochaetes P Oxidoreductase, NAD-binding domain - - - - - - - - - - - - FAD_binding_8,Ferric_reduct,NAD_binding_1 k59_523237_3 1035308.AQYY01000002_gene664 1.51e-12 70.9 COG5274@1|root,COG5274@2|Bacteria 2|Bacteria C heme binding - - - - - - - - - - - - Cyt-b5 k59_915503_1 497964.CfE428DRAFT_4290 4.44e-52 176.0 COG0448@1|root,COG0448@2|Bacteria,46SG2@74201|Verrucomicrobia 74201|Verrucomicrobia G Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_915503_2 1415779.JOMH01000001_gene1323 1.49e-19 82.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - - - - - - - - - - OMP_b-brl_3,Plug k59_130955_1 1122951.ATUE01000011_gene498 7.68e-09 53.5 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,3NNW9@468|Moraxellaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_130955_2 1304275.C41B8_17753 9.98e-14 66.2 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_654024_1 1458275.AZ34_04125 7.67e-23 95.1 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2VHA6@28216|Betaproteobacteria,4AA7B@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_654024_2 1484158.PSNIH1_15925 2.26e-74 227.0 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,3W0Q8@53335|Pantoea 1236|Gammaproteobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008830,GO:0009058,GO:0009059,GO:0009103,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046677,GO:0050896,GO:0051716,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2038,iBWG_1329.BWG_1828,iECDH10B_1368.ECDH10B_2188,iECSF_1327.ECSF_1927,iJO1366.b2038,iJR904.b2038,iYL1228.KPN_02488 dTDP_sugar_isom k59_176_1 765910.MARPU_07625 1.04e-92 285.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales 135613|Chromatiales E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_457882_1 525373.HMPREF0766_14221 1.45e-57 190.0 COG1409@1|root,COG1409@2|Bacteria,4NI6R@976|Bacteroidetes,1IQQZ@117747|Sphingobacteriia 976|Bacteroidetes S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_882868_1 96561.Dole_2877 1.25e-65 212.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,2MJ1N@213118|Desulfobacterales 28221|Deltaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_621332_2 1122194.AUHU01000007_gene255 2.56e-30 112.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,466ZE@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0234 family yajQ GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K09767 - - - - ko00000 - - - DUF520 k59_915506_1 552398.HMPREF0866_01881 5.61e-139 425.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,3WGS6@541000|Ruminococcaceae 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_850179_1 1278309.KB907100_gene2158 5.09e-103 311.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XNPB@135619|Oceanospirillales 135619|Oceanospirillales C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_555972_1 1198232.CYCME_0037 2.31e-12 72.8 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,4627S@72273|Thiotrichales 72273|Thiotrichales D PFAM Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_464594_1 563040.Saut_1884 2.39e-93 276.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2YP8T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D nucleotide-binding protein implicated in inhibition of septum formation maf - - ko:K06287 - - - - ko00000 - - - Maf k59_464594_2 326298.Suden_1897 7.04e-47 157.0 COG5615@1|root,COG5615@2|Bacteria,1Q1KK@1224|Proteobacteria,42TX3@68525|delta/epsilon subdivisions,2YPV4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S integral membrane protein - - - - - - - - - - - - - k59_464594_3 563040.Saut_1886 2.9e-39 145.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2YMJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_170460_1 1121289.JHVL01000035_gene2625 1.16e-05 46.2 COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,36DKA@31979|Clostridiaceae 186801|Clostridia H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10005,iHN637.CLJU_RS10010 IlvC,IlvN k59_170460_2 304371.MCP_2699 5.12e-61 193.0 COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,2N9NK@224756|Methanomicrobia 224756|Methanomicrobia E Acetolactate synthase, small subunit ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_170460_3 526218.Sterm_0105 1.02e-229 650.0 COG0028@1|root,COG0028@2|Bacteria,378RW@32066|Fusobacteria 32066|Fusobacteria H acetolactate synthase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_888257_1 1120966.AUBU01000005_gene3575 4.41e-95 285.0 COG0657@1|root,COG0657@2|Bacteria,4NJ8D@976|Bacteroidetes,47TQ4@768503|Cytophagia 976|Bacteroidetes I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3,DLH,Lipase_GDSL_2,Peptidase_S9 k59_660681_2 472759.Nhal_1173 2.98e-49 162.0 COG2062@1|root,COG2062@2|Bacteria,1RGWQ@1224|Proteobacteria,1S9W7@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine phosphatase superfamily (branch 1) sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_137652_2 768671.ThimaDRAFT_2161 0.0 953.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_137652_3 765913.ThidrDRAFT_3541 2.4e-146 417.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1WX9V@135613|Chromatiales 135613|Chromatiales E TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_137652_4 1049564.TevJSym_ba00190 4.1e-139 400.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1J5AE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_137652_5 1249627.D779_1884 4.34e-140 405.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1WXRN@135613|Chromatiales 135613|Chromatiales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_137652_6 765912.Thimo_0721 7.07e-102 301.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_137652_7 1249627.D779_1886 7.29e-89 265.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales 135613|Chromatiales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_137652_8 1249627.D779_1887 1.92e-97 293.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1WX0N@135613|Chromatiales 135613|Chromatiales I Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_137652_9 765912.Thimo_0724 9.03e-74 234.0 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1X2WY@135613|Chromatiales 135613|Chromatiales I Belongs to the CDS family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_137652_10 713586.KB900536_gene135 3.98e-172 494.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales 135613|Chromatiales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_137652_11 768671.ThimaDRAFT_2152 1.62e-163 476.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1WW2V@135613|Chromatiales 135613|Chromatiales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_38633_28 202955.BBND01000013_gene1164 7.46e-17 84.7 28IZ5@1|root,2Z8WP@2|Bacteria,1R6WI@1224|Proteobacteria,1S87I@1236|Gammaproteobacteria,3NM14@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_38633_29 41431.PCC8801_3357 6.64e-53 191.0 COG0438@1|root,COG0438@2|Bacteria,1G1WR@1117|Cyanobacteria,3KIHB@43988|Cyanothece 1117|Cyanobacteria M PFAM glycosyl transferase group 1 - - - ko:K12993 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_38633_30 43989.cce_4556 1.3e-30 123.0 2AWP9@1|root,31NK6@2|Bacteria,1G6HF@1117|Cyanobacteria 1117|Cyanobacteria S Galactose-3-O-sulfotransferase - - - - - - - - - - - - Gal-3-0_sulfotr,Sulfotransfer_2 k59_38633_31 1569209.BBPH01000004_gene1641 1.86e-81 275.0 COG1132@1|root,COG1132@2|Bacteria,1MXC2@1224|Proteobacteria,2TTB6@28211|Alphaproteobacteria,2PY5Z@265|Paracoccus 28211|Alphaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_38633_32 1485545.JQLW01000001_gene1449 1.02e-07 62.0 COG1215@1|root,COG1215@2|Bacteria,1RBGS@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 k59_38633_33 1120972.AUMH01000019_gene2331 2.5e-09 67.0 COG0535@1|root,COG0535@2|Bacteria,1V3RE@1239|Firmicutes,4HST7@91061|Bacilli 91061|Bacilli C Elongator protein 3, MiaB family, Radical SAM - - - ko:K22227 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_38633_35 2340.JV46_20250 3.88e-114 334.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1J5PU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_38633_36 1249627.D779_2061 2.2e-32 119.0 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1WZFD@135613|Chromatiales 135613|Chromatiales U PFAM Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_38633_37 1049564.TevJSym_ap00620 5.85e-63 194.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,1J799@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_38633_38 317025.Tcr_0818 1.44e-103 300.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,46002@72273|Thiotrichales 72273|Thiotrichales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_38633_39 1249627.D779_2058 1.55e-91 276.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_38633_40 472759.Nhal_3697 1.15e-265 731.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_38633_41 765912.Thimo_0589 3.23e-80 243.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, E subunit - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_38633_42 1049564.TevJSym_ap00570 4.33e-136 396.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1J4GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1020246_1 1122599.AUGR01000001_gene416 4.61e-53 187.0 COG0304@1|root,COG0304@2|Bacteria,1MV67@1224|Proteobacteria,1RMXJ@1236|Gammaproteobacteria,1XHM8@135619|Oceanospirillales 135619|Oceanospirillales IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.180 ko:K18473 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_105647_2 1168034.FH5T_01600 1.06e-33 127.0 COG1217@1|root,COG1217@2|Bacteria,4NDVM@976|Bacteroidetes,2FMNU@200643|Bacteroidia 976|Bacteroidetes T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_824229_1 1283300.ATXB01000001_gene1792 8.19e-78 248.0 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1XDPA@135618|Methylococcales 135618|Methylococcales T Histidine kinase - - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c k59_497723_1 1131269.AQVV01000003_gene698 1.71e-109 334.0 COG0365@1|root,COG0365@2|Bacteria 2|Bacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006083,GO:0006084,GO:0006085,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006473,GO:0006476,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016054,GO:0016405,GO:0016787,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018193,GO:0018205,GO:0018394,GO:0019213,GO:0019427,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033558,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034421,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043687,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045733,GO:0046390,GO:0046395,GO:0046483,GO:0050218,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072329,GO:0072521,GO:0072522,GO:0090407,GO:0098732,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - iE2348C_1286.E2348C_4392,iYL1228.KPN_04478 ACAS_N,AMP-binding,AMP-binding_C k59_1020259_1 1116472.MGMO_138c00240 4.09e-06 49.3 COG1216@1|root,COG1216@2|Bacteria,1QV95@1224|Proteobacteria,1T2AK@1236|Gammaproteobacteria,1XDMA@135618|Methylococcales 135618|Methylococcales S Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 k59_922785_1 387093.SUN_0392 1.51e-45 162.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2YMSR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M apolipoprotein N-acyltransferase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_366865_1 1165841.SULAR_10014 7.06e-48 174.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2YMVS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C k59_366865_2 1165841.SULAR_10019 4.57e-46 168.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,1QUIU@1224|Proteobacteria,42M7I@68525|delta/epsilon subdivisions,2YMX0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG3893 inactivated superfamily I helicase addB - - - - - - - - - - - PDDEXK_1 k59_235854_1 469616.FMAG_00146 4.42e-54 186.0 COG5002@1|root,COG5002@2|Bacteria,37CVJ@32066|Fusobacteria 32066|Fusobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_105659_1 933262.AXAM01000013_gene1295 1.01e-23 93.6 COG1609@1|root,COG1609@2|Bacteria,1QW0S@1224|Proteobacteria,43BQP@68525|delta/epsilon subdivisions,2X71R@28221|Deltaproteobacteria,2MM94@213118|Desulfobacterales 28221|Deltaproteobacteria K Helix-turn-helix - - - - - - - - - - - - HTH_3 k59_105659_2 1121405.dsmv_2328 9.11e-21 91.3 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2MID0@213118|Desulfobacterales 28221|Deltaproteobacteria NU TIGRFAM type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_987709_1 765910.MARPU_15605 1.1e-16 77.8 COG3187@1|root,COG3187@2|Bacteria,1R0YJ@1224|Proteobacteria,1T4RM@1236|Gammaproteobacteria 1236|Gammaproteobacteria O O COG3187 Heat shock protein - - - - - - - - - - - - META k59_987709_2 1205680.CAKO01000040_gene585 8.14e-28 107.0 28H7B@1|root,2Z7JJ@2|Bacteria,1MX57@1224|Proteobacteria,2TQZS@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Putative 2OG-Fe(II) oxygenase - - - - - - - - - - - - 2OG-FeII_Oxy_5 k59_431248_1 637389.Acaty_c1397 1.27e-39 149.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,2NC2M@225057|Acidithiobacillales 225057|Acidithiobacillales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_235856_1 105420.BBPO01000015_gene5029 3.12e-06 46.6 COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria,2NINY@228398|Streptacidiphilus 201174|Actinobacteria CO Thioredoxin trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 - - - Thioredoxin k59_235856_2 765911.Thivi_0620 6.45e-60 190.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_72593_2 105559.Nwat_3039 6.85e-42 146.0 2AI7D@1|root,33HQ0@2|Bacteria,1P2AB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_497742_1 1168034.FH5T_04285 1.84e-68 215.0 COG3279@1|root,COG3279@2|Bacteria,4NIYS@976|Bacteroidetes,2FN6U@200643|Bacteroidia 976|Bacteroidetes KT COG3279 Response regulator of the LytR AlgR family - - - - - - - - - - - - LytTR,Response_reg k59_497742_2 1168034.FH5T_04290 1.72e-05 45.8 COG0778@1|root,COG0778@2|Bacteria,4NJ80@976|Bacteroidetes,2FNX6@200643|Bacteroidia 976|Bacteroidetes C Nitroreductase family - - 1.5.1.38,1.5.1.39 ko:K19285,ko:K19286 ko00740,ko01100,map00740,map01100 - R05705,R05706 RC00126 ko00000,ko00001,ko01000 - - - Nitroreductase k59_987714_1 1168034.FH5T_12310 6.61e-79 256.0 COG3968@1|root,COG3968@2|Bacteria,4NG2B@976|Bacteroidetes,2FMC9@200643|Bacteroidia 976|Bacteroidetes S Glutamate--ammonia ligase, catalytic domain protein glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C k59_693491_1 387093.SUN_1643 1.54e-94 284.0 COG3076@1|root,COG3076@2|Bacteria,1N195@1224|Proteobacteria,42YI2@68525|delta/epsilon subdivisions,2YRF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Family of unknown function (DUF695) - - - - - - - - - - - - DUF695,RraB k59_235864_1 1443125.Z962_06615 3.56e-12 65.9 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,36FRF@31979|Clostridiaceae 186801|Clostridia E Histidinol phosphate phosphatase, HisJ family - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP k59_235864_2 306263.Cla_0563 6.54e-29 111.0 COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,42SG5@68525|delta/epsilon subdivisions,2YPIZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Staphylococcal nuclease homologues - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase k59_235864_3 1087448.Eab7_2695 7.97e-18 79.3 COG4446@1|root,COG4446@2|Bacteria,1VDZG@1239|Firmicutes,4HN9R@91061|Bacilli 91061|Bacilli S Protein of unknown function (DUF1499) - - - - - - - - - - - - DUF1499 k59_399196_1 1123399.AQVE01000004_gene2539 8.66e-84 268.0 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_563150_1 857087.Metme_4126 4.46e-93 281.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1XDMX@135618|Methylococcales 135618|Methylococcales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_334579_1 1168034.FH5T_08670 6.15e-250 717.0 COG0060@1|root,COG0060@2|Bacteria,4NEYT@976|Bacteroidetes,2FM5R@200643|Bacteroidia 976|Bacteroidetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_888997_1 1286171.EAL2_c12110 1.08e-50 172.0 COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,25V2D@186806|Eubacteriaceae 186801|Clostridia E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_888997_2 572544.Ilyop_0340 6.25e-203 569.0 COG0137@1|root,COG0137@2|Bacteria,3788R@32066|Fusobacteria 32066|Fusobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_987725_1 485915.Dret_2433 5.88e-73 236.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,42MHN@68525|delta/epsilon subdivisions,2WJU0@28221|Deltaproteobacteria,2M939@213115|Desulfovibrionales 28221|Deltaproteobacteria P Arsenical pump membrane protein - - - - - - - - - - - - CitMHS k59_267856_1 631362.Thi970DRAFT_04435 1.2e-86 268.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RS8H@1236|Gammaproteobacteria,1WWVZ@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_563156_1 1163407.UU7_04927 6.53e-24 102.0 COG2885@1|root,COG2885@2|Bacteria,1RB3C@1224|Proteobacteria,1S36Z@1236|Gammaproteobacteria,1X77V@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the ompA family - - - - - - - - - - - - OmpA k59_366898_1 1449069.JMLO01000011_gene2447 7.63e-22 98.2 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4FU1X@85025|Nocardiaceae 201174|Actinobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8 k59_300621_1 240015.ACP_3096 5.56e-114 338.0 COG0137@1|root,COG0137@2|Bacteria,3Y3DD@57723|Acidobacteria,2JIZD@204432|Acidobacteriia 204432|Acidobacteriia E Belongs to the argininosuccinate synthase family. Type 2 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_105700_1 1123399.AQVE01000031_gene195 5.06e-09 60.5 COG0741@1|root,COG0741@2|Bacteria 2|Bacteria M lytic transglycosylase activity - - - - - - - - - - - - SLT k59_105700_2 768671.ThimaDRAFT_1867 2.6e-32 120.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales 135613|Chromatiales S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_366905_1 296591.Bpro_1117 2.81e-69 224.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9V8@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator yfhA - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_399217_1 367737.Abu_1740 3.98e-42 142.0 COG0735@1|root,COG0735@2|Bacteria,1NCW6@1224|Proteobacteria,42VHY@68525|delta/epsilon subdivisions,2YQK2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the Fur family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_399217_2 1449345.JHWC01000002_gene1394 5.89e-37 128.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2YPGD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_72634_1 385682.AFSL01000048_gene512 4.85e-46 155.0 COG2253@1|root,COG2253@2|Bacteria,4NPW4@976|Bacteroidetes,2FSGR@200643|Bacteroidia 976|Bacteroidetes S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_235890_2 1168034.FH5T_14775 2.16e-23 94.4 2EFWM@1|root,339NX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_235890_3 1391647.AVSV01000028_gene169 1.32e-07 50.1 COG1254@1|root,COG1254@2|Bacteria,1VEM9@1239|Firmicutes,24QXB@186801|Clostridia,36MTY@31979|Clostridiaceae 186801|Clostridia C acylphosphatase acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_170942_1 1355368.JART01000001_gene671 5.6e-105 311.0 COG3943@1|root,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,42NYC@68525|delta/epsilon subdivisions,2YN8N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Virulence protein RhuM family - - - - - - - - - - - - Virulence_RhuM k59_497786_1 319225.Plut_1041 1.93e-54 179.0 COG3527@1|root,COG3527@2|Bacteria 2|Bacteria Q acetolactate decarboxylase activity budA GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0047605 4.1.1.5 ko:K01575 ko00650,ko00660,map00650,map00660 - R02948 RC00812 ko00000,ko00001,ko01000 - - - AAL_decarboxy k59_138468_1 290315.Clim_0685 1.77e-43 148.0 COG1348@1|root,COG1348@2|Bacteria,1FDR5@1090|Chlorobi 1090|Chlorobi F The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_138468_2 869213.JCM21142_93552 5.5e-29 105.0 COG0347@1|root,COG0347@2|Bacteria,4NS3T@976|Bacteroidetes 976|Bacteroidetes K Nitrogen regulatory protein P-II - - - ko:K02589 - - - - ko00000 - - - P-II k59_203163_1 675806.VII_001690 2.92e-32 123.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1XT5N@135623|Vibrionales 135623|Vibrionales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains flaK - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FleQ,HTH_8,Sigma54_activat k59_203163_2 675806.VII_001691 6.1e-25 101.0 COG5000@1|root,COG5000@2|Bacteria,1QUG9@1224|Proteobacteria,1T1Y1@1236|Gammaproteobacteria,1XSAF@135623|Vibrionales 135623|Vibrionales T COG0642 Signal transduction histidine kinase flrB - 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_8 k59_399226_1 398527.Bphyt_0234 2.59e-32 126.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K69S@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_628323_1 56780.SYN_01350 4e-47 164.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria,2MQBU@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3198 AA_kinase,PUA k59_72646_1 1122962.AULH01000065_gene2876 1.48e-09 60.1 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,3704V@31993|Methylocystaceae 28211|Alphaproteobacteria O Hsp20/alpha crystallin family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_72646_2 262316.MAP_1740c 3.31e-11 65.9 COG3829@1|root,COG4585@1|root,COG3829@2|Bacteria,COG4585@2|Bacteria,2I4F7@201174|Actinobacteria,23D6Q@1762|Mycobacteriaceae 201174|Actinobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA_3,PAS k59_563185_1 255470.cbdbA109 2.8e-170 516.0 COG0326@1|root,COG0326@2|Bacteria,2G9ND@200795|Chloroflexi 200795|Chloroflexi O Molecular chaperone. Has ATPase activity - - - - - - - - - - - - - k59_72647_1 69395.JQLZ01000002_gene1193 5.98e-16 79.7 COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,2KGAW@204458|Caulobacterales 204458|Caulobacterales S PFAM GumN family protein - - - ko:K09973 - - - - ko00000 - - - TraB k59_366931_1 1056820.KB900629_gene1708 1.42e-153 436.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,2PMKT@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Ribosomal Proteins L2, C-terminal domain rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_960961_1 1168034.FH5T_01690 1.79e-121 351.0 COG1788@1|root,COG1788@2|Bacteria,4NF3T@976|Bacteroidetes,2FS2V@200643|Bacteroidia 976|Bacteroidetes I Branched-chain amino acid dehydrogenase scoA - 2.8.3.5,2.8.3.6,2.8.3.8,2.8.3.9 ko:K01027,ko:K01028,ko:K01031,ko:K01034 ko00072,ko00280,ko00310,ko00362,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00072,map00280,map00310,map00362,map00627,map00640,map00650,map01100,map01120,map02020 - R00410,R01179,R01359,R01365,R02990,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_960961_2 1121918.ARWE01000001_gene2378 0.000256 42.7 COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,42PZY@68525|delta/epsilon subdivisions,2WJ9V@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Acyl CoA acetate 3-ketoacid CoA transferase beta subunit - - 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_145141_1 99598.Cal7507_3246 4.47e-52 180.0 COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,1HJR6@1161|Nostocales 1117|Cyanobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_111423_1 1168034.FH5T_00285 6.37e-50 160.0 COG3288@1|root,COG3288@2|Bacteria,4NT78@976|Bacteroidetes,2FU0R@200643|Bacteroidia 976|Bacteroidetes C Pyridine nucleotide transhydrogenase pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM k59_111423_2 1168034.FH5T_00280 3.18e-46 158.0 COG3288@1|root,COG3288@2|Bacteria,4NGH1@976|Bacteroidetes,2G2N7@200643|Bacteroidia 976|Bacteroidetes C NAD(P)( ) transhydrogenase (AB-specific), alpha subunit pntAA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_405110_1 526218.Sterm_1905 6.04e-76 240.0 COG1364@1|root,COG1364@2|Bacteria,37BER@32066|Fusobacteria 32066|Fusobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_177520_1 1499967.BAYZ01000182_gene4431 1.55e-97 299.0 arCOG09146@1|root,2ZPZ6@2|Bacteria 2|Bacteria S Transposase - - - - - - - - - - - - - k59_341362_1 933262.AXAM01000125_gene3208 4.03e-33 120.0 COG1286@1|root,COG1286@2|Bacteria,1RJE1@1224|Proteobacteria,42SCW@68525|delta/epsilon subdivisions,2WPNX@28221|Deltaproteobacteria,2MKBI@213118|Desulfobacterales 28221|Deltaproteobacteria S Colicin V production protein - - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_830256_1 1122971.BAME01000026_gene2715 3.03e-05 52.0 COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,2FPEC@200643|Bacteroidia,22WHR@171551|Porphyromonadaceae 976|Bacteroidetes G Glycosyl hydrolase family 2, sugar binding domain protein - - - - - - - - - - - - Glyco_hydro_106 k59_764647_1 765912.Thimo_1854 5.83e-42 148.0 COG0475@1|root,COG0475@2|Bacteria,1QTSD@1224|Proteobacteria,1T1FK@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Sodium hydrogen exchanger - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger k59_764647_2 472759.Nhal_3602 5.26e-44 153.0 COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C7@1236|Gammaproteobacteria,1X2MB@135613|Chromatiales 135613|Chromatiales O Radical SAM superfamily - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_537096_1 96561.Dole_2188 1.54e-70 240.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2WKEN@28221|Deltaproteobacteria,2MIWJ@213118|Desulfobacterales 28221|Deltaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_44177_1 483215.BACFIN_05398 2.42e-21 99.0 COG1629@1|root,COG4771@2|Bacteria,4NFFW@976|Bacteroidetes,2FMGS@200643|Bacteroidia,4AMHY@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - Plug,TonB_dep_Rec k59_177531_1 926562.Oweho_0255 3.79e-34 127.0 2DZSS@1|root,32VHZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_209995_1 746697.Aeqsu_0886 6.1e-86 283.0 COG1747@1|root,COG1747@2|Bacteria,4NEB8@976|Bacteroidetes,1HXVQ@117743|Flavobacteriia 976|Bacteroidetes S SprA protein sprA - - - - - - - - - - - SprA_N k59_764651_1 929558.SMGD1_2124 4.25e-68 230.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2YMYH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1025839_1 472759.Nhal_2361 4.78e-21 89.4 2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1SDRS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_994300_1 264732.Moth_1338 2.81e-38 135.0 COG0135@1|root,COG0135@2|Bacteria,1V6Y0@1239|Firmicutes,24HBQ@186801|Clostridia,42GMF@68295|Thermoanaerobacterales 186801|Clostridia E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_994300_2 574087.Acear_1866 2.64e-182 516.0 COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,3WBCA@53433|Halanaerobiales 186801|Clostridia E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_405125_1 998088.B565_0493 6.96e-115 347.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RQ36@1236|Gammaproteobacteria,1Y3TY@135624|Aeromonadales 135624|Aeromonadales L Belongs to the DEAD box helicase family - - 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C k59_111436_1 869213.JCM21142_104169 1.9e-19 86.7 COG3256@1|root,COG3256@2|Bacteria,4NG9H@976|Bacteroidetes,47K63@768503|Cytophagia 976|Bacteroidetes P Cytochrome C and Quinol oxidase polypeptide I - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_111436_2 869213.JCM21142_104170 5.49e-112 328.0 COG2846@1|root,COG2846@2|Bacteria,4NE9M@976|Bacteroidetes,47P55@768503|Cytophagia 976|Bacteroidetes D Di-iron-containing protein involved in the repair of iron-sulfur clusters ric - - ko:K07322 - - - - ko00000 - - - Hemerythrin,ScdA_N k59_960988_1 1283300.ATXB01000001_gene2262 8.64e-147 433.0 COG0388@1|root,COG1247@1|root,COG0388@2|Bacteria,COG1247@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1XENX@135618|Methylococcales 135618|Methylococcales M PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_470370_1 1168034.FH5T_21000 3.74e-77 243.0 COG0436@1|root,COG0436@2|Bacteria,4NHP7@976|Bacteroidetes,2FN3D@200643|Bacteroidia 976|Bacteroidetes E Aminotransferase, class I alaC - - - - - - - - - - - Aminotran_1_2 k59_273237_1 765911.Thivi_3155 1.03e-35 142.0 COG1165@1|root,COG1165@2|Bacteria,1MVMZ@1224|Proteobacteria,1RNRS@1236|Gammaproteobacteria,1WW3X@135613|Chromatiales 135613|Chromatiales H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_8399_1 1349822.NSB1T_00370 2.32e-72 238.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,4NECB@976|Bacteroidetes,2FNV6@200643|Bacteroidia,22WAM@171551|Porphyromonadaceae 976|Bacteroidetes J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_44181_1 864069.MicloDRAFT_00006080 1.14e-80 246.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria,1JQZG@119045|Methylobacteriaceae 28211|Alphaproteobacteria L IstB-like ATP binding protein MA20_10895 - - - - - - - - - - - IstB_IS21 k59_44181_2 1217720.ALOX01000121_gene1566 2.79e-239 670.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2JUC0@204441|Rhodospirillales 204441|Rhodospirillales L Cytoplasmic - - - - - - - - - - - - rve k59_306511_1 1249627.D779_0916 2.82e-87 275.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WXQN@135613|Chromatiales 135613|Chromatiales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_794612_1 1168034.FH5T_13840 5.78e-35 121.0 COG0011@1|root,COG0011@2|Bacteria 2|Bacteria H TIGRFAM Protein of M1-594 - - - - - - - - - - - Thiamine_BP k59_794612_2 1168034.FH5T_13835 8.88e-39 136.0 2B0HH@1|root,31SV0@2|Bacteria,4NRU4@976|Bacteroidetes,2FTFR@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_764677_1 1121456.ATVA01000008_gene3236 1.45e-77 235.0 COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,42RB9@68525|delta/epsilon subdivisions,2WMPE@28221|Deltaproteobacteria,2MB1R@213115|Desulfovibrionales 28221|Deltaproteobacteria C Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex bfr - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_210023_1 1349822.NSB1T_08605 2e-12 67.8 COG1011@1|root,COG1011@2|Bacteria,4NM66@976|Bacteroidetes,2FMM5@200643|Bacteroidia,22XNU@171551|Porphyromonadaceae 976|Bacteroidetes S Hydrolase yjjG - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_210023_2 1168034.FH5T_12485 1.14e-110 322.0 COG0313@1|root,COG0313@2|Bacteria,4NFQM@976|Bacteroidetes,2FMU1@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_405148_1 572544.Ilyop_0365 5.19e-71 226.0 COG0787@1|root,COG0787@2|Bacteria,378YT@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_667917_1 768671.ThimaDRAFT_3069 1.85e-82 267.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WXQN@135613|Chromatiales 135613|Chromatiales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_764694_1 290315.Clim_1949 9.84e-43 157.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1FDBJ@1090|Chlorobi 1090|Chlorobi T histidine kinase A domain protein - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,Response_reg,dCache_3 k59_177580_1 987059.RBXJA2T_14051 1.98e-57 187.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VMPX@28216|Betaproteobacteria,1KIXZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR1 - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_470404_1 1123517.JOMR01000001_gene513 1.75e-53 182.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,45ZP3@72273|Thiotrichales 72273|Thiotrichales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_437328_2 709032.Sulku_2040 2.47e-68 216.0 COG0310@1|root,COG0310@2|Bacteria,1NTQK@1224|Proteobacteria,42REN@68525|delta/epsilon subdivisions,2YP4K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Cobalt uptake substrate-specific transmembrane region - - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_437328_3 941824.TCEL_01401 6.45e-16 78.2 COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia,36EPJ@31979|Clostridiaceae 186801|Clostridia P Cobalamin (Vitamin B12) biosynthesis CbiM protein nikMN - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM,PDGLE k59_306556_1 443143.GM18_3176 9.79e-25 107.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,42PSZ@68525|delta/epsilon subdivisions,2WMBH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_929207_1 387093.SUN_1889 1.8e-61 213.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2YMFS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_634852_1 880071.Fleli_1793 2.8e-141 412.0 COG2224@1|root,COG2224@2|Bacteria,4NH57@976|Bacteroidetes,47MRW@768503|Cytophagia 976|Bacteroidetes C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_731324_1 1168034.FH5T_15150 4.13e-108 323.0 COG1940@1|root,COG1940@2|Bacteria,4NFZ1@976|Bacteroidetes,2FNAA@200643|Bacteroidia 976|Bacteroidetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HTH_24,MarR,ROK k59_504922_1 1168034.FH5T_21325 8.24e-136 393.0 COG0078@1|root,COG0078@2|Bacteria,4NEYX@976|Bacteroidetes,2FPNE@200643|Bacteroidia 976|Bacteroidetes E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline - - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_504922_2 686340.Metal_2791 1.39e-107 319.0 COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the carbamate kinase family arcC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - iE2348C_1286.E2348C_0454,iECED1_1282.ECED1_0540,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iJN746.PP_0999 AA_kinase k59_341438_1 197221.22296039 2.12e-34 127.0 COG0031@1|root,COG0031@2|Bacteria,1G0T4@1117|Cyanobacteria 1117|Cyanobacteria E cysteine synthase cysM - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_306563_1 63737.Npun_R5724 6.31e-210 591.0 COG3033@1|root,COG3033@2|Bacteria,1G33V@1117|Cyanobacteria,1HQEM@1161|Nostocales 1117|Cyanobacteria E Beta-eliminating lyase tpl - 4.1.99.2 ko:K01668 ko00350,map00350 - R00728 RC00355,RC00364 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_830334_1 1049564.TevJSym_bb00330 1.75e-74 249.0 COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,1J501@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Adenylate cyclase cyaA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 ko:K05851 ko00230,ko02026,ko05111,map00230,map02026,map05111 - R00089,R00434 RC00295 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365 Adenyl_cycl_N,Adenylate_cycl k59_794635_1 387093.SUN_1375 4.59e-107 333.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2YM8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_862500_1 1165841.SULAR_08859 3.87e-95 289.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2YME3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P sulfate adenylyltransferase sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_731335_2 767817.Desgi_2043 1.96e-15 76.3 COG1143@1|root,COG1143@2|Bacteria,1UJ43@1239|Firmicutes,25EVE@186801|Clostridia,2605I@186807|Peptococcaceae 186801|Clostridia C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein asrA - - ko:K16950 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - Fer4_22 k59_405185_2 1304885.AUEY01000072_gene1710 1.56e-49 169.0 COG2605@1|root,COG2605@2|Bacteria,1QW1A@1224|Proteobacteria,42N0X@68525|delta/epsilon subdivisions,2WK4R@28221|Deltaproteobacteria,2MKF9@213118|Desulfobacterales 28221|Deltaproteobacteria S GHMP kinases C terminal - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_895998_1 1249480.B649_09375 1.85e-92 279.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2YMR8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_438065_2 211165.AJLN01000120_gene752 2.65e-15 84.0 COG3299@1|root,COG3299@2|Bacteria,1GKHR@1117|Cyanobacteria,1JM83@1189|Stigonemataceae 1117|Cyanobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_831080_1 857087.Metme_1792 1.85e-61 197.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1XE9F@135618|Methylococcales 135618|Methylococcales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_635613_1 765912.Thimo_2753 1.8e-69 213.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1WXYG@135613|Chromatiales 135613|Chromatiales Q PFAM Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_635613_2 765911.Thivi_3233 1.16e-84 256.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,1WWID@135613|Chromatiales 135613|Chromatiales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_765533_2 997884.HMPREF1068_00494 1.26e-29 119.0 COG0463@1|root,COG0463@2|Bacteria,4PN4G@976|Bacteroidetes,2G0PY@200643|Bacteroidia 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_273929_1 742727.HMPREF9447_01588 3.17e-92 289.0 COG3401@1|root,COG3401@2|Bacteria,4NFM5@976|Bacteroidetes,2FPSM@200643|Bacteroidia,4ANKU@815|Bacteroidaceae 976|Bacteroidetes S candidate rhamnogalacturonan lyase, polysaccharide lyase family 11 protein K01238 - - 4.2.2.23 ko:K18197 - - - - ko00000,ko01000 - PL11 - - k59_471127_1 1226325.HMPREF1548_03674 5.78e-05 45.4 COG0352@1|root,COG0637@1|root,COG0352@2|Bacteria,COG0637@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,36I8K@31979|Clostridiaceae 186801|Clostridia H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_603097_1 1121127.JAFA01000003_gene2053 1.14e-19 89.4 2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,2VWAN@28216|Betaproteobacteria,1K4AW@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_273930_1 1131451.O1K_18278 1.11e-75 251.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1X4R3@135614|Xanthomonadales 135614|Xanthomonadales E homoserine dehydrogenase thrA - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_145989_1 1151116.Q7S_00535 1.05e-12 73.2 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,1S1IZ@1236|Gammaproteobacteria,3FH10@34037|Rahnella 1236|Gammaproteobacteria T Diguanylate cyclase phosphodiesterase with extracellular sensor yhjK GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0052652,GO:0052653,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - EAL,GAPES3,GGDEF,HAMP k59_505794_1 563040.Saut_2157 2.04e-40 147.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2YN94@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_505794_2 1249480.B649_11775 5.36e-31 114.0 2BTTK@1|root,32P16@2|Bacteria,1Q41F@1224|Proteobacteria,42Y3I@68525|delta/epsilon subdivisions,2YQQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_79197_1 1304275.C41B8_09551 2.58e-81 254.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_79197_4 768671.ThimaDRAFT_3221 4.48e-24 93.6 COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1WYUC@135613|Chromatiales 135613|Chromatiales S Membrane fusogenic activity - - - ko:K09806 - - - - ko00000 - - - BMFP k59_79197_5 1049564.TevJSym_at00600 2.65e-224 634.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1J5DV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATPase with chaperone activity comM GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0042623,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_79197_6 1535422.ND16A_3444 2.21e-116 351.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,2Q8CP@267889|Colwelliaceae 1236|Gammaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_79197_7 1049564.TevJSym_al00240 1.75e-40 142.0 2EN7Y@1|root,33FVR@2|Bacteria,1NHR8@1224|Proteobacteria,1SH6M@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_935826_3 1307761.L21SP2_3140 7.55e-187 527.0 COG0673@1|root,COG0673@2|Bacteria,2J71R@203691|Spirochaetes 203691|Spirochaetes S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_248885_2 1177179.A11A3_02842 4.58e-07 53.5 2DHS9@1|root,300R6@2|Bacteria,1NHA8@1224|Proteobacteria,1SHGE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S HIRAN - - - - - - - - - - - - HIRAN k59_609333_2 635013.TherJR_1797 1.35e-08 55.1 COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,261T1@186807|Peptococcaceae 186801|Clostridia J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_801206_3 439235.Dalk_1318 2.11e-59 187.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,43BHF@68525|delta/epsilon subdivisions,2WQUJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_675099_1 765913.ThidrDRAFT_0006 1.79e-95 301.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1X257@135613|Chromatiales 135613|Chromatiales P PFAM von Willebrand factor type A - - - - - - - - - - - - VWA k59_968233_1 1122201.AUAZ01000003_gene1993 4.6e-154 445.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,4654B@72275|Alteromonadaceae 1236|Gammaproteobacteria E Required for the activity of the bacterial periplasmic transport system of putrescine potF1 - - ko:K11073 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - SBP_bac_8 k59_348524_1 572544.Ilyop_1837 2.26e-37 134.0 COG2165@1|root,COG2165@2|Bacteria 2|Bacteria NU general secretion pathway protein - - - ko:K02246,ko:K02247,ko:K02456,ko:K02457,ko:K02458,ko:K10924 ko03070,ko05111,map03070,map05111 M00331,M00429 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,SBP_bac_10 k59_313472_1 742766.HMPREF9455_03838 4.95e-57 182.0 COG0235@1|root,COG0235@2|Bacteria,4NGMP@976|Bacteroidetes,2FMV0@200643|Bacteroidia,22WKM@171551|Porphyromonadaceae 976|Bacteroidetes G Class II Aldolase and Adducin N-terminal domain araD - 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_801215_1 1168034.FH5T_12420 3.85e-51 171.0 COG0343@1|root,COG0343@2|Bacteria,4NE15@976|Bacteroidetes,2FMUM@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_801215_2 1168034.FH5T_12425 1.94e-33 129.0 COG1215@1|root,COG1215@2|Bacteria,4NESG@976|Bacteroidetes,2FN9E@200643|Bacteroidia 976|Bacteroidetes M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_248902_2 1168034.FH5T_22000 1.88e-44 153.0 COG0115@1|root,COG0115@2|Bacteria,4NR4I@976|Bacteroidetes,2FT3N@200643|Bacteroidia 976|Bacteroidetes EH Amino-transferase class IV - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_379966_1 911239.CF149_09057 1.08e-36 126.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_379966_2 765910.MARPU_16650 3e-30 118.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_641902_1 1122185.N792_05765 4.02e-85 273.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,1RQUG@1236|Gammaproteobacteria,1X59Q@135614|Xanthomonadales 135614|Xanthomonadales S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_641902_2 991905.SL003B_3342 1.32e-37 133.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria,4BQNR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_543904_2 62977.ACIAD3077 2.57e-06 50.4 2AJVR@1|root,31AIH@2|Bacteria,1QFZZ@1224|Proteobacteria,1TDBM@1236|Gammaproteobacteria,3NQIM@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_543904_3 749222.Nitsa_1224 0.000208 42.7 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2YMD4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulatory protein yebC - - - - - - - - - - - Transcrip_reg k59_348538_1 1442599.JAAN01000030_gene2146 1.6e-87 277.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales 135614|Xanthomonadales S transporter oliA - - - - - - - - - - - OPT k59_738028_1 709991.Odosp_2667 4.17e-28 110.0 COG1979@1|root,COG1979@2|Bacteria,4NF1D@976|Bacteroidetes,2FPAW@200643|Bacteroidia,22W7C@171551|Porphyromonadaceae 976|Bacteroidetes C alcohol dehydrogenase yqhD - - ko:K08325 ko00640,map00640 - R02528 RC00739 ko00000,ko00001,ko01000 - - - Fe-ADH k59_936642_2 1267535.KB906767_gene2036 4.28e-39 136.0 COG3335@1|root,COG3335@2|Bacteria 2|Bacteria L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3 k59_642624_1 1168034.FH5T_10870 9.79e-43 156.0 COG0188@1|root,COG0188@2|Bacteria,4NERI@976|Bacteroidetes,2FPAU@200643|Bacteroidia 976|Bacteroidetes L Belongs to the type II topoisomerase GyrA ParC subunit family parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_topoisoIV k59_1002140_1 765911.Thivi_0916 1.35e-78 242.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales 135613|Chromatiales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_217953_1 1123274.KB899413_gene790 1.83e-41 150.0 COG0303@1|root,COG0303@2|Bacteria,2J7HN@203691|Spirochaetes 203691|Spirochaetes H MoeA C-terminal region (domain IV) moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_936646_1 526227.Mesil_1253 1.48e-16 76.3 COG0292@1|root,COG0292@2|Bacteria,1WK7V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_544685_1 251229.Chro_1890 3.43e-09 62.8 COG4773@1|root,COG4773@2|Bacteria,1G13I@1117|Cyanobacteria,3VHXW@52604|Pleurocapsales 1117|Cyanobacteria P COGs COG4773 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - iECBD_1354.fhuA AMIN,Plug,TonB_dep_Rec k59_870252_1 1165841.SULAR_08597 1.87e-67 219.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2YMWG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U COG1459 Type II secretory pathway, component PulF - - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_86293_1 202952.BBLI01000030_gene2188 3.27e-23 110.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,3NN17@468|Moraxellaceae 1236|Gammaproteobacteria Q Bacterial Ig-like domain (group 3) - - - - - - - - - - - - Big_3_2,VCBS k59_119433_1 272134.KB731324_gene3814 1.56e-131 388.0 COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,1H992@1150|Oscillatoriales 1117|Cyanobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_936650_1 83406.HDN1F_29010 1.7e-114 365.0 COG0433@1|root,COG0433@2|Bacteria,1NAXG@1224|Proteobacteria,1SJQR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 3'(2'),5'-bisphosphate nucleotidase activity - - - - - - - - - - - - Inovirus_Gp2 k59_610085_1 1168034.FH5T_14650 1.5e-84 257.0 COG0506@1|root,COG0506@2|Bacteria,4NKZB@976|Bacteroidetes,2FW9Q@200643|Bacteroidia 976|Bacteroidetes E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh k59_903494_1 314278.NB231_05591 1.3e-95 293.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1WW6B@135613|Chromatiales 135613|Chromatiales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_772743_1 1537915.JU57_03735 1.02e-146 431.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2YNNW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,NADH-G_4Fe-4S_3 k59_772743_2 760154.Sulba_0411 6.13e-91 280.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2YNE6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_152972_2 454957.IA64_03840 3.22e-37 132.0 COG0251@1|root,COG0251@2|Bacteria,1RD3E@1224|Proteobacteria,1S6NI@1236|Gammaproteobacteria,1X6JQ@135614|Xanthomonadales 135614|Xanthomonadales J translation initiation inhibitor, yjgF family tdcF - - - - - - - - - - - Ribonuc_L-PSP k59_512873_1 765911.Thivi_4245 1.85e-86 278.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1WW7D@135613|Chromatiales 135613|Chromatiales C Molybdopterin oxidoreductase Fe4S4 domain napA - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_936664_1 1501230.ET33_22710 6.97e-27 114.0 COG2227@1|root,COG3321@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins - - - ko:K13612 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_870263_2 1163617.SCD_n02065 2.33e-57 191.0 COG4360@1|root,COG4360@2|Bacteria,1RB5I@1224|Proteobacteria,2W0KI@28216|Betaproteobacteria 28216|Betaproteobacteria F ATP adenylyltransferase (5',5''-P-1,P-4-tetraphosphate phosphorylase II) - - - - - - - - - - - - - k59_936669_1 1121445.ATUZ01000013_gene1250 2.78e-13 74.7 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2M8F9@213115|Desulfovibrionales 28221|Deltaproteobacteria T Signal transducing histidine kinase homodimeric - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_380732_1 1287476.HMPREF1651_08530 2.19e-47 162.0 COG2834@1|root,COG2834@2|Bacteria,4NIT5@976|Bacteroidetes,2G0SU@200643|Bacteroidia 976|Bacteroidetes M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_412886_1 563040.Saut_2107 4.65e-45 150.0 2AJSH@1|root,31AEU@2|Bacteria,1Q5GG@1224|Proteobacteria,42QZH@68525|delta/epsilon subdivisions,2YP33@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_412886_2 1537917.JU82_07245 9.93e-42 150.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2YMF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_51751_1 1121129.KB903359_gene1631 1.41e-110 344.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NJW1@976|Bacteroidetes,2FNET@200643|Bacteroidia,22WN6@171551|Porphyromonadaceae 976|Bacteroidetes EU Peptidase, S9A B C family, catalytic domain protein - - - - - - - - - - - - PD40,Peptidase_S9 k59_675890_1 709032.Sulku_1298 3.61e-11 60.8 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,42W01@68525|delta/epsilon subdivisions,2YQEH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Dinitrogenase iron-molybdenum cofactor biosynthesis protein - - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_675890_2 990073.ATHU01000001_gene1794 2.22e-44 147.0 2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,42TEY@68525|delta/epsilon subdivisions,2YPN1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nitrogen fixation protein - - - - - - - - - - - - DUF269 k59_512898_1 653045.Strvi_9197 6.01e-24 95.9 COG0454@1|root,COG0456@2|Bacteria,2IFM6@201174|Actinobacteria 201174|Actinobacteria K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_512898_2 247633.GP2143_13661 1.73e-08 55.8 COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,1RRYS@1236|Gammaproteobacteria,1J6RV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P ZIP Zinc transporter - - - ko:K16267 - - - - ko00000,ko02000 2.A.5.4.11 - - Zip k59_544718_1 225937.HP15_2624 1.37e-76 243.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,465HT@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0733 Na -dependent transporters of the SNF family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_707553_1 1122925.KB895376_gene445 4.63e-06 54.3 COG3299@1|root,COG3299@2|Bacteria,1TQZU@1239|Firmicutes,4HN2E@91061|Bacilli,26QKE@186822|Paenibacillaceae 1239|Firmicutes S Baseplate J family protein - - - - - - - - - - - - Baseplate_J k59_838127_1 987059.RBXJA2T_00330 1.9e-82 256.0 COG1988@1|root,COG1988@2|Bacteria,1QK5N@1224|Proteobacteria,2VK9U@28216|Betaproteobacteria,1KJKS@119065|unclassified Burkholderiales 28216|Betaproteobacteria S LexA-binding, inner membrane-associated putative hydrolase - - - ko:K07038 - - - - ko00000 - - - YdjM k59_412898_1 944435.AXAJ01000005_gene3490 1.52e-64 216.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VH3R@28216|Betaproteobacteria,1JZVT@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_675906_1 929558.SMGD1_0424 8.56e-99 316.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,42M05@68525|delta/epsilon subdivisions,2YNMZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Bacterial NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_349312_1 1236689.MMALV_02640 5.93e-20 92.4 COG0613@1|root,arCOG00302@2157|Archaea,2Y3KK@28890|Euryarchaeota 28890|Euryarchaeota S PHP-associated - - - - - - - - - - - - PHP_C k59_249640_1 96561.Dole_0867 5.78e-31 125.0 COG2204@1|root,COG3829@1|root,COG4191@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,2MJZM@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_838133_1 85643.Tmz1t_2439 2.01e-49 172.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,2KUZF@206389|Rhodocyclales 206389|Rhodocyclales E Aminotransferase tyrB - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_772775_1 1125863.JAFN01000001_gene2314 1.73e-100 298.0 COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,42Q20@68525|delta/epsilon subdivisions,2WP8Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria M GlcNAc-PI de-N-acetylase - - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L k59_16030_1 1003200.AXXA_22735 1.21e-37 137.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,3T1QY@506|Alcaligenaceae 28216|Betaproteobacteria O Membrane protease subunits, stomatin prohibitin homologs qmcA - - - - - - - - - - - Band_7,Band_7_C k59_16030_2 1458275.AZ34_12300 3.23e-05 46.2 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,4AC6C@80864|Comamonadaceae 28216|Betaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_314329_1 1504822.CCNO01000013_gene380 7.18e-72 228.0 COG2255@1|root,COG2255@2|Bacteria,2NNUG@2323|unclassified Bacteria 2|Bacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_16031_1 1288826.MSNKSG1_18654 4.12e-21 93.2 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,4655F@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3344 Retron-type reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_412914_1 95619.PM1_0225625 2.45e-37 140.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Lipoprotein releasing system transmembrane protein lolE - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_119503_1 1041138.KB890244_gene4968 7.36e-91 273.0 COG0702@1|root,COG0702@2|Bacteria,1MW44@1224|Proteobacteria,2TT9D@28211|Alphaproteobacteria,4BDCD@82115|Rhizobiaceae 28211|Alphaproteobacteria GM NmrA-like family - - - - - - - - - - - - NAD_binding_10,NmrA k59_1033572_1 1317124.DW2_06863 8.46e-83 270.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,2XMF0@285107|Thioclava 28211|Alphaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_870301_1 387093.SUN_1111 1.71e-93 281.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2YMG4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - iIT341.HP1375 Acetyltransf_11,Hexapep k59_314345_1 1537917.JU82_01570 1.2e-96 293.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2YNGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_936735_1 414684.RC1_3446 1.03e-22 100.0 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2U8WW@28211|Alphaproteobacteria,2JSKJ@204441|Rhodospirillales 204441|Rhodospirillales M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_707588_1 1168034.FH5T_07850 4.7e-98 299.0 COG2244@1|root,COG2244@2|Bacteria,4NDZ0@976|Bacteroidetes,2FKYU@200643|Bacteroidia 976|Bacteroidetes S Polysaccharide biosynthesis protein cap - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_349348_2 1049564.TevJSym_bb00160 2.39e-22 92.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_870309_1 1042377.AFPJ01000054_gene1686 4.62e-73 238.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,469KU@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_412931_1 1168034.FH5T_01895 6.65e-26 105.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,4NETY@976|Bacteroidetes,2FM2Z@200643|Bacteroidia 976|Bacteroidetes F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_412931_2 1168034.FH5T_01890 4.51e-51 166.0 COG0693@1|root,COG0693@2|Bacteria,4NQI1@976|Bacteroidetes,2G38B@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score yajL - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_486292_1 1504981.KO116_3059 1.53e-13 77.4 COG0651@1|root,COG0651@2|Bacteria,1N6BY@1224|Proteobacteria,1RR4C@1236|Gammaproteobacteria 1236|Gammaproteobacteria CP formate hydrogenlyase subunit 3 multisubunit Na H antiporter, MnhD subunit - - - - - - - - - - - - Proton_antipo_M k59_781961_1 338966.Ppro_0408 6.4e-21 96.7 29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_846667_1 1500304.JQKY01000017_gene2228 2.66e-42 153.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,2U0H9@28211|Alphaproteobacteria,4B86V@82115|Rhizobiaceae 28211|Alphaproteobacteria M Transglycosylase SLT domain mltF GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_95244_1 1121405.dsmv_1666 1.58e-98 320.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_651322_1 1262449.CP6013_0072 1.13e-106 324.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36DK7@31979|Clostridiaceae 186801|Clostridia C Belongs to the aldehyde dehydrogenase family gapN - 1.2.1.9 ko:K00131 ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200 M00308,M00633 R01058 RC00242 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_455724_1 1168034.FH5T_10395 2.03e-12 66.6 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,2FQSG@200643|Bacteroidia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23,OEP k59_128260_2 1485544.JQKP01000003_gene223 3e-12 63.9 COG0236@1|root,COG0236@2|Bacteria,1NEMA@1224|Proteobacteria,2VW0X@28216|Betaproteobacteria,44WHU@713636|Nitrosomonadales 28216|Betaproteobacteria IQ Phosphopantetheine attachment site - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_716254_1 1150621.SMUL_1045 3.14e-118 363.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,42M8I@68525|delta/epsilon subdivisions,2YN4J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 k59_651332_1 292415.Tbd_1582 1.97e-106 335.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,1KSFY@119069|Hydrogenophilales 119069|Hydrogenophilales V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_846685_1 1246448.ANAZ01000026_gene3356 1.97e-07 57.0 COG0568@1|root,COG0568@2|Bacteria,2ID1P@201174|Actinobacteria,4EGBU@85012|Streptosporangiales 201174|Actinobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_357875_1 1122201.AUAZ01000009_gene2762 2.96e-85 266.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,46AE2@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM,DctQ k59_357875_2 1382356.JQMP01000001_gene743 1.04e-39 142.0 COG2084@1|root,COG2084@2|Bacteria,2G6B3@200795|Chloroflexi,27Y9G@189775|Thermomicrobia 189775|Thermomicrobia I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.60 ko:K00042 ko00630,ko01100,map00630,map01100 - R01745,R01747 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_912201_1 96561.Dole_1747 2.98e-52 173.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,42STV@68525|delta/epsilon subdivisions,2WKKA@28221|Deltaproteobacteria,2MJB6@213118|Desulfobacterales 28221|Deltaproteobacteria O Tellurite resistance protein TerB - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_1043045_1 316067.Geob_3419 2.26e-44 159.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2WJTV@28221|Deltaproteobacteria,43T4H@69541|Desulfuromonadales 28221|Deltaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iAF987.Gmet_1886 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_357877_1 997829.HMPREF1121_00505 1.42e-55 186.0 COG1187@1|root,COG1187@2|Bacteria,4NEE1@976|Bacteroidetes,2FP7M@200643|Bacteroidia,22WKX@171551|Porphyromonadaceae 976|Bacteroidetes J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_357877_2 1168034.FH5T_11180 2.99e-54 173.0 COG1595@1|root,COG1595@2|Bacteria,4NETF@976|Bacteroidetes,2FNPY@200643|Bacteroidia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_486338_2 936136.ARRT01000006_gene4526 1.88e-24 104.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2TRVM@28211|Alphaproteobacteria,4BAQI@82115|Rhizobiaceae 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_1010879_1 1049564.TevJSym_bk00210 5.35e-101 305.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1J4SA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - iYL1228.KPN_02462 AdoHcyase,AdoHcyase_NAD k59_846691_1 1163617.SCD_n01730 8.86e-73 241.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria 28216|Betaproteobacteria P von Willebrand factor (vWF) type A domain - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - VWA_2 k59_716278_1 931277.C448_06705 1.87e-33 121.0 arCOG06222@1|root,arCOG06222@2157|Archaea,2XYMX@28890|Euryarchaeota,23WRM@183963|Halobacteria 183963|Halobacteria S Polyketide cyclase dehydrase - - - - - - - - - - - - Polyketide_cyc2 k59_227003_1 1260251.SPISAL_03530 1.42e-45 158.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1WXAD@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_357890_1 1165841.SULAR_08362 1.23e-116 342.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2YN3J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_390846_1 1049564.TevJSym_aj00510 5.25e-249 694.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1J6D6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter nhaD - - - - - - - - - - - CitMHS k59_390846_2 1049564.TevJSym_aj00480 3.48e-220 620.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1J5ND@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0277 FAD FMN-containing dehydrogenases dld - 1.1.5.12 ko:K03777 ko00620,ko01120,map00620,map01120 - R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_390846_3 326442.PSHAa2525 1.25e-41 145.0 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,2Q0FN@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S periplasmic or secreted lipoprotein yraP GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944 - - - - - - - - - - BON k59_390846_4 95619.PM1_0206575 8.42e-28 106.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the UPF0102 family yraN - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_390846_5 1158762.KB898044_gene313 1.09e-45 179.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1WX80@135613|Chromatiales 135613|Chromatiales M PFAM LppC - - - ko:K07121 - - - - ko00000 - - - LppC k59_390846_6 264730.PSPPH_4118 1.55e-97 296.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1Z67I@136849|Pseudomonas syringae group 1236|Gammaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_390846_7 765913.ThidrDRAFT_3404 0.0 908.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales 135613|Chromatiales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_390846_8 1049564.TevJSym_an00750 2.78e-113 330.0 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1J5U7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis rnt GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T k59_390846_9 765913.ThidrDRAFT_3401 3.05e-79 246.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1WW1D@135613|Chromatiales 135613|Chromatiales M PFAM VacJ family lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_390846_10 243233.MCA1687 1.09e-216 619.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales 135618|Methylococcales S AAA-like domain - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 k59_390846_11 1049564.TevJSym_am00650 5.71e-265 729.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1J4BT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_390846_12 572477.Alvin_0409 7.31e-150 433.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales 135613|Chromatiales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_390846_13 1238182.C882_4137 1.51e-303 859.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2JPCQ@204441|Rhodospirillales 204441|Rhodospirillales P COG2217 Cation transport ATPase copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_390846_14 1177594.MIC448_570010 7.15e-07 48.9 COG2608@1|root,COG2608@2|Bacteria 2|Bacteria P mercury ion transmembrane transporter activity - - - - - - - - - - - - HMA k59_586439_1 439235.Dalk_2281 8.79e-77 245.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42Z00@68525|delta/epsilon subdivisions,2WTI9@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Nickel-dependent hydrogenase - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_322444_1 1319815.HMPREF0202_00653 2.54e-55 186.0 COG0438@1|root,COG0438@2|Bacteria,379AK@32066|Fusobacteria 32066|Fusobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_684943_1 1168034.FH5T_18820 2.26e-86 281.0 COG2887@1|root,COG2887@2|Bacteria,4NFZQ@976|Bacteroidetes,2FN03@200643|Bacteroidia 976|Bacteroidetes L DNA-dependent ATPase I and helicase II - - - - - - - - - - - - PDDEXK_1 k59_486354_1 1168034.FH5T_07170 7.24e-114 337.0 COG1940@1|root,COG1940@2|Bacteria,4NFZ1@976|Bacteroidetes,2FNEQ@200643|Bacteroidia 976|Bacteroidetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HTH_24,MarR,ROK k59_25068_1 640081.Dsui_3157 5.98e-80 261.0 28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,2VMEK@28216|Betaproteobacteria 28216|Betaproteobacteria M Pfam Fatty acid cti - - - - - - - - - - - CTI k59_684944_1 926564.KI911686_gene5587 5.8e-109 346.0 COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4F38B@85017|Promicromonosporaceae 201174|Actinobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_227010_1 1168034.FH5T_17100 8.99e-60 201.0 COG2070@1|root,COG2070@2|Bacteria,4NEGW@976|Bacteroidetes 976|Bacteroidetes S 2-Nitropropane dioxygenase - - - - - - - - - - - - - k59_227010_2 1168034.FH5T_17165 6.66e-91 269.0 COG4843@1|root,COG4843@2|Bacteria,4NRH5@976|Bacteroidetes,2FSZ5@200643|Bacteroidia 976|Bacteroidetes S Uncharacterized protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 k59_811127_1 1288826.MSNKSG1_06138 2.94e-93 284.0 COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,1RSCK@1236|Gammaproteobacteria,463XY@72275|Alteromonadaceae 1236|Gammaproteobacteria S Saccharopine dehydrogenase lys - - - - - - - - - - - Sacchrp_dh_NADP k59_522407_1 243365.CV_3115 3.81e-63 226.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KQFG@206351|Neisseriales 206351|Neisseriales NU Neisseria PilC beta-propeller domain - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_258637_1 1366050.N234_28120 3.03e-40 153.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VICN@28216|Betaproteobacteria,1K3Q3@119060|Burkholderiaceae 28216|Betaproteobacteria T ATP-binding region ATPase domain protein - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase k59_912225_1 744980.TRICHSKD4_1721 1.53e-32 126.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2TTUE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S release factor H-coupled RctB family protein - - 6.5.1.3 ko:K14415,ko:K18148 ko01501,map01501 - - - ko00000,ko00001,ko01000,ko03016 - - - RtcB k59_587402_1 358681.BBR47_57990 3.8e-50 168.0 COG0765@1|root,COG0765@2|Bacteria,1UJ2B@1239|Firmicutes,4HYI5@91061|Bacilli,277DS@186822|Paenibacillaceae 91061|Bacilli P Binding-protein-dependent transport system inner membrane component - - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_228232_1 1168034.FH5T_07960 3.82e-130 386.0 COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,2FUCA@200643|Bacteroidia 976|Bacteroidetes S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_913278_1 1476973.JMMB01000007_gene1432 8.84e-16 81.3 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,25R30@186804|Peptostreptococcaceae 186801|Clostridia C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_812260_1 1163671.JAGI01000002_gene974 5.94e-40 143.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae 186801|Clostridia I Belongs to the thiolase family thlA - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_812260_2 1511.CLOST_0198 2.7e-35 127.0 COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,248TX@186801|Clostridia 186801|Clostridia S beta-keto acid cleavage enzyme - - 2.3.1.247 ko:K18013 ko00310,map00310 - R10564 RC02728,RC03199 ko00000,ko00001,ko01000 - - - BKACE k59_717514_1 1122963.AUHB01000005_gene2855 1.94e-41 150.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,36XWY@31993|Methylocystaceae 28211|Alphaproteobacteria E HMGL-like nifV - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_422487_1 1168034.FH5T_18480 4.55e-28 105.0 COG1528@1|root,COG1528@2|Bacteria,4NGS7@976|Bacteroidetes,2FQD1@200643|Bacteroidia 976|Bacteroidetes P Iron-storage protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin k59_422487_2 1168034.FH5T_18485 0.0 1011.0 COG0317@1|root,COG0317@2|Bacteria,4NESY@976|Bacteroidetes,2FKYN@200643|Bacteroidia 976|Bacteroidetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_290918_1 999141.GME_09786 5.87e-63 210.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1XIJ5@135619|Oceanospirillales 135619|Oceanospirillales O ATPase with chaperone activity - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1044123_1 1165841.SULAR_05843 1.62e-154 443.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2YN91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_422512_1 190304.FN0349 0.000374 41.6 COG1490@1|root,COG1490@2|Bacteria,37AR6@32066|Fusobacteria 32066|Fusobacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_422512_2 1319815.HMPREF0202_00345 1.44e-50 173.0 COG1488@1|root,COG1488@2|Bacteria,378M8@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase k59_1011824_1 485915.Dret_0339 5e-21 93.6 COG3605@1|root,COG3605@2|Bacteria 2|Bacteria T phosphoenolpyruvate-protein phosphotransferase activity - - 4.2.1.75,4.6.1.1 ko:K01719,ko:K01768,ko:K02584 ko00230,ko00860,ko01100,ko01110,ko01120,ko02020,ko02025,ko04113,ko04213,map00230,map00860,map01100,map01110,map01120,map02020,map02025,map04113,map04213 M00121,M00695 R00089,R00434,R03165 RC00295,RC01861 ko00000,ko00001,ko00002,ko01000,ko03000 - - - ANTAR,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HATPase_c_2,HisKA_2 k59_259815_1 1049564.TevJSym_ad01430 1.6e-135 393.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1J4I4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_323705_1 977880.RALTA_A0435 1.28e-138 401.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,1K06B@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_913308_1 1168034.FH5T_05005 1.64e-92 276.0 COG0130@1|root,COG0130@2|Bacteria,4NESK@976|Bacteroidetes,2FMTY@200643|Bacteroidia 976|Bacteroidetes J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C_2,TruB_N k59_259824_1 1278073.MYSTI_00428 3.33e-19 83.6 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RIQ@68525|delta/epsilon subdivisions,2WNC7@28221|Deltaproteobacteria,2YW44@29|Myxococcales 28221|Deltaproteobacteria S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_259824_2 130081.XP_005708294.1 0.000197 44.7 2E385@1|root,2SACI@2759|Eukaryota 2759|Eukaryota S NUDIX domain - - - - - - - - - - - - NUDIX k59_422536_1 1168034.FH5T_07425 3.68e-105 309.0 COG0664@1|root,COG0664@2|Bacteria,4NRFI@976|Bacteroidetes,2G2ZU@200643|Bacteroidia 976|Bacteroidetes K Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_422536_2 1168034.FH5T_07430 5.13e-19 83.6 COG1145@1|root,COG1145@2|Bacteria,4NI4X@976|Bacteroidetes,2FN3Z@200643|Bacteroidia 976|Bacteroidetes C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_6 k59_555721_1 536232.CLM_2185 3.76e-17 82.8 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,36V04@31979|Clostridiaceae 186801|Clostridia T GHKL domain - - 2.7.13.3 ko:K18345 ko01502,ko02020,map01502,map02020 M00651,M00656 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HAMP,HATPase_c,HisKA k59_555721_4 536227.CcarbDRAFT_2298 1.03e-82 266.0 COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,36W9X@31979|Clostridiaceae 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5 k59_555721_5 469616.FMAG_01379 4.96e-91 276.0 COG0501@1|root,COG0501@2|Bacteria,3790I@32066|Fusobacteria 32066|Fusobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_456901_1 1195246.AGRI_06785 4.56e-34 135.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,465VG@72275|Alteromonadaceae 1236|Gammaproteobacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_323729_1 1122194.AUHU01000002_gene2870 2.71e-43 153.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,464ZQ@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1722) ybgA - - - - - - - - - - - DUF1722,DUF523 k59_96405_1 172088.AUGA01000021_gene5141 4.03e-39 135.0 COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,2TR4K@28211|Alphaproteobacteria,3JY40@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_812304_1 326442.PSHAa1036 6.41e-09 61.6 2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,1S5UD@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_913329_1 395961.Cyan7425_2245 8.02e-19 85.9 COG1525@1|root,COG1525@2|Bacteria,1G6B2@1117|Cyanobacteria,3KIR6@43988|Cyanothece 1117|Cyanobacteria L nuclease - - - - - - - - - - - - Excalibur,SNase k59_913329_2 1249627.D779_1749 3.49e-79 251.0 COG1988@1|root,COG1988@2|Bacteria,1Q0WR@1224|Proteobacteria,1RU1K@1236|Gammaproteobacteria,1X1D8@135613|Chromatiales 135613|Chromatiales S LexA-binding, inner membrane-associated putative hydrolase - - - ko:K07038 - - - - ko00000 - - - YdjM k59_26122_1 768670.Calni_0505 2.58e-26 114.0 COG0664@1|root,COG1033@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,2GFIN@200930|Deferribacteres 200930|Deferribacteres K Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - MMPL k59_259846_1 395019.Bmul_1421 2.16e-35 134.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,1JZXP@119060|Burkholderiaceae 28216|Betaproteobacteria H MoeA domain protein domain I and II moeA1 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_978987_1 1537917.JU82_08690 1.82e-154 449.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_359043_1 1408164.MOLA814_01453 7.63e-39 142.0 COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2VJB5@28216|Betaproteobacteria 28216|Betaproteobacteria G TRAP-type C4-dicarboxylate transport system periplasmic component - - - - - - - - - - - - DctP k59_392066_1 314278.NB231_07482 1.92e-127 380.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW7H@135613|Chromatiales 135613|Chromatiales V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_788186_1 1232410.KI421422_gene2071 4.27e-115 357.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,43S73@69541|Desulfuromonadales 28221|Deltaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_722856_2 387093.SUN_1010 4.5e-63 204.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2YN4M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0283 DHQ_synthase k59_624817_1 232346.JHQL01000003_gene614 1.9e-29 112.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1XH4S@135619|Oceanospirillales 135619|Oceanospirillales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_624817_2 396588.Tgr7_1531 3.01e-15 77.8 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales 135613|Chromatiales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_134851_1 748658.KB907319_gene774 3.33e-70 227.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1S1NC@1236|Gammaproteobacteria,1X06R@135613|Chromatiales 135613|Chromatiales T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_264917_1 936596.HMPREF1495_2273 4.31e-39 147.0 COG1461@1|root,COG1461@2|Bacteria,1TQMX@1239|Firmicutes,247XI@186801|Clostridia,1HVGT@1164882|Lachnoanaerobaculum 186801|Clostridia S Dak1_2 - - - ko:K07030 - - - - ko00000 - - - Dak1_2,Dak2 k59_559846_1 760568.Desku_2104 1.84e-51 184.0 COG3547@1|root,COG3547@2|Bacteria,1TRSB@1239|Firmicutes,249AC@186801|Clostridia,261BQ@186807|Peptococcaceae 186801|Clostridia L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_722862_1 706587.Desti_5421 8.06e-98 303.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42NSP@68525|delta/epsilon subdivisions,2WMAD@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase N terminal - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_264920_1 1223410.KN050846_gene1097 9.08e-78 255.0 COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,1HXUG@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,OMP_b-brl_3,Plug k59_330983_1 525898.Sdel_0831 2.91e-65 219.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,42M8I@68525|delta/epsilon subdivisions,2YN4J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 k59_559849_1 1249480.B649_02845 3.25e-29 109.0 2AJNF@1|root,31A9U@2|Bacteria,1Q56P@1224|Proteobacteria,430NW@68525|delta/epsilon subdivisions,2YS38@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_559849_2 563040.Saut_0924 3.44e-70 234.0 COG4206@1|root,COG4206@2|Bacteria,1R0RR@1224|Proteobacteria,42TBR@68525|delta/epsilon subdivisions,2YPNP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - - k59_69031_1 1168034.FH5T_20105 1.31e-68 213.0 COG1729@1|root,COG1729@2|Bacteria,4NEM2@976|Bacteroidetes,2G3E7@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_16,TPR_21,TPR_6,TPR_7,TPR_8 k59_69031_2 1168034.FH5T_20110 9.68e-26 98.6 COG0054@1|root,COG0054@2|Bacteria,4NNUC@976|Bacteroidetes,2FNGS@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_199721_1 385682.AFSL01000089_gene924 1.03e-167 489.0 COG1208@1|root,COG4412@1|root,COG1208@2|Bacteria,COG4412@2|Bacteria,4NI02@976|Bacteroidetes,2FR2W@200643|Bacteroidia 976|Bacteroidetes JM N-acetylglucosamine-1-phosphate uridyltransferase - - - - - - - - - - - - BACON,DUF4859 k59_984279_1 1382303.JPOM01000001_gene1079 5.36e-05 51.6 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,2KFQU@204458|Caulobacterales 204458|Caulobacterales MU type I secretion outer membrane protein, TolC family - - - ko:K12340,ko:K12535 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00327,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_591711_2 1117647.M5M_19165 2.91e-70 221.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1J5VS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I yycJ - - - - - - - - - - - Lactamase_B_2 k59_984280_1 1168034.FH5T_09470 4.78e-201 565.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,2FQ0Q@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_363324_1 1168034.FH5T_17225 2.29e-149 435.0 COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,2FMMH@200643|Bacteroidia 976|Bacteroidetes H acetolactate synthase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_199724_2 1453505.JASY01000006_gene1239 1.83e-38 145.0 COG5434@1|root,COG5434@2|Bacteria,4NG4T@976|Bacteroidetes,1HZZB@117743|Flavobacteriia,2NSEJ@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_428394_1 572544.Ilyop_0248 1.18e-140 407.0 COG2805@1|root,COG2805@2|Bacteria,379F6@32066|Fusobacteria 32066|Fusobacteria NU COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_428394_2 572544.Ilyop_0249 5.07e-06 47.8 COG1459@1|root,COG1459@2|Bacteria,378GJ@32066|Fusobacteria 32066|Fusobacteria U type II secretion system - - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_134875_1 1217718.ALOU01000007_gene1361 0.000376 42.4 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,1JZWS@119060|Burkholderiaceae 28216|Betaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_134875_2 326298.Suden_2068 1.4e-83 251.0 COG0461@1|root,COG0461@2|Bacteria,1RIC5@1224|Proteobacteria,42M91@68525|delta/epsilon subdivisions,2YMTS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_885926_1 765912.Thimo_1931 2.04e-110 347.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_134877_1 439235.Dalk_2893 2.63e-45 158.0 COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,42NM0@68525|delta/epsilon subdivisions,2WM96@28221|Deltaproteobacteria,2MHSQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_919503_1 1123075.AUDP01000007_gene2698 1.64e-101 298.0 COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,3WJ1H@541000|Ruminococcaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_919503_2 744872.Spica_0915 6.11e-25 98.6 29IC7@1|root,3059E@2|Bacteria,2JAQH@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - k59_919503_3 865861.AZSU01000003_gene2170 2.54e-201 570.0 COG3493@1|root,COG3493@2|Bacteria,1TR97@1239|Firmicutes,24BDA@186801|Clostridia,36GMZ@31979|Clostridiaceae 186801|Clostridia C 2-hydroxycarboxylate transporter family citP - - ko:K11616 ko02020,map02020 - - - ko00000,ko00001 2.A.24.2 - - 2HCT k59_919503_4 1476973.JMMB01000007_gene316 7.25e-188 533.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,25QEB@186804|Peptostreptococcaceae 186801|Clostridia C Psort location Cytoplasmic, score - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_919503_5 1408422.JHYF01000007_gene1331 5.91e-81 248.0 COG4565@1|root,COG4565@2|Bacteria,1V49R@1239|Firmicutes,24BJS@186801|Clostridia,36HG7@31979|Clostridiaceae 186801|Clostridia KT transcriptional regulatory protein dctR - - ko:K02475,ko:K11615,ko:K11692,ko:K11712 ko02020,map02020 M00489,M00490 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_11,Response_reg k59_919503_6 393595.ABO_1598 2.28e-07 53.9 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XICT@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Response_reg k59_102102_1 1123514.KB905899_gene1276 5.69e-86 269.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,4607Q@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - - - - - - - - - - - G6PD_C,G6PD_N k59_428400_1 1049564.TevJSym_bd00260 5.45e-85 263.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1J7KN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain glpC GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3 ko:K00113,ko:K11473 ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130 - R00475,R00848 RC00029,RC00042 ko00000,ko00001,ko01000 - - - CCG,Fer4_8 k59_396138_1 387093.SUN_0649 3.11e-81 260.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2YMWQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_167716_1 1123326.JFBL01000001_gene1394 1.49e-86 271.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2YN7F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_331016_1 1134912.AJTV01000021_gene3009 6.63e-20 86.7 COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2TVJC@28211|Alphaproteobacteria,36ZAX@31993|Methylocystaceae 28211|Alphaproteobacteria C NADH ubiquinone oxidoreductase, 20 Kd subunit - - 1.12.1.2 ko:K18007 - - - - ko00000,ko01000 - - - Oxidored_q6 k59_331016_2 1304865.JAGF01000001_gene2440 5.44e-60 192.0 COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria 201174|Actinobacteria CH Oxidoreductase asrB - - - - - - - - - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_2640_1 1537917.JU82_08465 1.94e-114 344.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2YM8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.5.1 ko:K05922 - - - - ko00000,ko01000 - - - NiFeSe_Hases k59_591730_1 485913.Krac_2020 7.19e-05 44.7 COG0693@1|root,COG0693@2|Bacteria,2G8WZ@200795|Chloroflexi 200795|Chloroflexi S TIGRFAM intracellular protease, PfpI family - - 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_591730_2 1172190.M947_06155 1.67e-119 354.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2YMM3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin biosynthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_363343_1 1168034.FH5T_06210 8.3e-61 197.0 COG0182@1|root,COG0182@2|Bacteria,4NETC@976|Bacteroidetes,2FR7K@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_363343_2 1168034.FH5T_06205 7.82e-140 399.0 COG0005@1|root,COG0005@2|Bacteria,4P6SU@976|Bacteroidetes 976|Bacteroidetes F Phosphorylase superfamily - - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_363343_3 1408473.JHXO01000001_gene2351 1.29e-14 67.4 COG3360@1|root,COG3360@2|Bacteria 2|Bacteria P Dodecin secE2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K09165 - - - - ko00000 - - - Dodecin k59_134894_1 1225184.ALXE01000036_gene81 2.72e-71 221.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,3VXYP@53335|Pantoea 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_428417_1 595460.RRSWK_04316 4.73e-28 114.0 COG2957@1|root,COG2957@2|Bacteria 2|Bacteria E agmatine deiminase activity - GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004198,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.22.37,3.5.3.12 ko:K08589,ko:K10536 ko00330,ko01100,ko01503,map00330,map01100,map01503 - R01416 RC00177 ko00000,ko00001,ko01000,ko01002 - - - PAD_porph,Peptidase_C25,Peptidase_C25_C,Propeptide_C25 k59_167727_1 1120942.AUBM01000006_gene966 1.52e-05 52.8 COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GJBR@201174|Actinobacteria,4D4ES@85005|Actinomycetales 201174|Actinobacteria D cell division protein FtsK - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_SpoIIIE,Yop-YscD_cpl k59_331026_1 1396418.BATQ01000071_gene524 2.71e-38 145.0 COG1502@1|root,COG1502@2|Bacteria,46TDH@74201|Verrucomicrobia,2IVBU@203494|Verrucomicrobiae 203494|Verrucomicrobiae I Phospholipase D. Active site motifs. - - - - - - - - - - - - PLDc_2 k59_69064_1 929558.SMGD1_2649 1.38e-294 820.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2YMT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_559881_1 331113.SNE_A00630 1.31e-11 70.9 COG3210@1|root,COG4625@1|root,COG3210@2|Bacteria,COG4625@2|Bacteria,2JGCS@204428|Chlamydiae 204428|Chlamydiae U Autotransporter beta-domain - - - - - - - - - - - - Autotransporter,PATR k59_624873_1 1472716.KBK24_0109085 3.61e-14 71.2 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,1K09S@119060|Burkholderiaceae 28216|Betaproteobacteria E transglutaminase domain protein - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_624873_2 765420.OSCT_3174 6.09e-09 59.3 COG2307@1|root,COG2307@2|Bacteria,2GAAJ@200795|Chloroflexi,374SB@32061|Chloroflexia 32061|Chloroflexia S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_331027_1 1540257.JQMW01000004_gene462 6.46e-19 88.6 COG4753@1|root,COG4753@2|Bacteria,1TPFP@1239|Firmicutes,24AIA@186801|Clostridia,36G5B@31979|Clostridiaceae 186801|Clostridia T YcbB domain - - - ko:K07719 ko02020,map02020 M00518 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,YcbB k59_951851_1 572544.Ilyop_0508 2.58e-45 158.0 COG4591@1|root,COG4591@2|Bacteria,378S1@32066|Fusobacteria 32066|Fusobacteria M Psort location CytoplasmicMembrane, score 10.00 - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_951851_2 484022.Fphi_0609 2.64e-95 289.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,45ZZ1@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_363354_1 1150626.PHAMO_170055 6.4e-30 119.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2JRK3@204441|Rhodospirillales 204441|Rhodospirillales C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_363354_2 316057.RPD_1531 4.71e-94 281.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,3JTAE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain MA20_01040 - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_690265_1 631362.Thi970DRAFT_02476 5.06e-166 475.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_690265_2 1111732.AZOD01000023_gene1869 1.49e-35 130.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1X73J@135614|Xanthomonadales 135614|Xanthomonadales Q ABC-type transport system involved in resistance to organic solvents auxiliary component - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_690265_3 2340.JV46_16010 3.53e-196 563.0 COG2271@1|root,COG2271@2|Bacteria,1QUF4@1224|Proteobacteria,1RPSF@1236|Gammaproteobacteria,1JC0D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Acetyl-coenzyme A transporter 1 ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - Acatn,MFS_1 k59_690265_5 1232410.KI421413_gene692 1.63e-50 177.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria,43UBD@69541|Desulfuromonadales 28221|Deltaproteobacteria I TIGRFAM malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_690265_6 2340.JV46_21850 2.64e-73 228.0 COG2356@1|root,COG2356@2|Bacteria,1MXQM@1224|Proteobacteria,1RPX9@1236|Gammaproteobacteria,1JB5I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease I endA - 3.1.21.1 ko:K01150 - - - - ko00000,ko01000 - - - Endonuclease_1 k59_690265_7 765912.Thimo_2980 3.23e-95 297.0 COG1524@1|root,COG1524@2|Bacteria,1R2II@1224|Proteobacteria,1RQDZ@1236|Gammaproteobacteria,1X2CP@135613|Chromatiales 135613|Chromatiales S PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_690265_8 880072.Desac_1760 2.36e-87 266.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42SWD@68525|delta/epsilon subdivisions,2WK1W@28221|Deltaproteobacteria,2MQCQ@213462|Syntrophobacterales 28221|Deltaproteobacteria K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_690265_9 338963.Pcar_0519 2.08e-82 261.0 2E1TH@1|root,32X3B@2|Bacteria,1NKJB@1224|Proteobacteria 1224|Proteobacteria S Legionella pneumophila major outer membrane protein precursor - - - - - - - - - - - - Legionella_OMP k59_690265_11 985054.JQEZ01000001_gene2043 5.99e-27 105.0 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2UC0F@28211|Alphaproteobacteria,4NC86@97050|Ruegeria 28211|Alphaproteobacteria S CBS domain - - - - - - - - - - - - CBS k59_690265_12 391615.ABSJ01000041_gene22 3.61e-106 317.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,1S44I@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_690874_3 1173028.ANKO01000229_gene1828 0.000618 46.2 COG1404@1|root,COG2931@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4935@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family M1-820 - - - - - - - - - - - Collagen,HemolysinCabind,PKD,P_proprotein,Peptidase_S8 k59_984973_1 97139.C824_05297 3.78e-51 169.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,36EQW@31979|Clostridiaceae 186801|Clostridia KT response regulator srrA_2 - - - - - - - - - - - Response_reg,Trans_reg_C k59_984973_2 411474.COPEUT_00741 1.05e-13 70.9 COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia 186801|Clostridia L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_396788_1 545697.HMPREF0216_01694 5.13e-307 841.0 COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia,36DZU@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 1 family abgA - 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT1 - Glyco_hydro_1 k59_396788_2 1232446.BAIE02000085_gene1141 3.74e-304 833.0 COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 1 family - - 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT1 - Glyco_hydro_1 k59_396788_3 525268.HMPREF0308_0428 6.06e-13 75.5 COG0561@1|root,COG0561@2|Bacteria,2HGFH@201174|Actinobacteria,22K27@1653|Corynebacteriaceae 201174|Actinobacteria S hydrolases of the HAD superfamily ywpJ - - - - - - - - - - - Hydrolase_3 k59_168483_1 326298.Suden_2032 1.61e-22 93.6 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42RV5@68525|delta/epsilon subdivisions,2YP89@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_331713_1 1042377.AFPJ01000028_gene2277 2.91e-58 191.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,464SQ@72275|Alteromonadaceae 1236|Gammaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_135691_1 96561.Dole_3103 1.7e-85 264.0 COG1960@1|root,COG1960@2|Bacteria,1PUXP@1224|Proteobacteria,42YQ2@68525|delta/epsilon subdivisions,2WUBI@28221|Deltaproteobacteria,2MMS0@213118|Desulfobacterales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase type 2 domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_592431_1 641524.ADICYQ_5108 2.36e-12 71.6 COG4932@1|root,COG4932@2|Bacteria 2|Bacteria M domain protein - - - - - - - - - - - - FG-GAP,VCBS,VWA k59_1017768_1 1121405.dsmv_0584 5e-10 58.2 COG1433@1|root,COG1433@2|Bacteria,1RHT9@1224|Proteobacteria,42T9R@68525|delta/epsilon subdivisions,2WPV5@28221|Deltaproteobacteria,2MK8D@213118|Desulfobacterales 28221|Deltaproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_920220_1 388413.ALPR1_03475 3.61e-91 275.0 COG4912@1|root,COG4912@2|Bacteria,4NKBS@976|Bacteroidetes,47NRV@768503|Cytophagia 976|Bacteroidetes L DNA alkylation repair enzyme - - - - - - - - - - - - DNA_alkylation k59_920220_2 373903.Hore_13637 8.7e-91 270.0 COG0655@1|root,COG0655@2|Bacteria,1TRKM@1239|Firmicutes,24AD6@186801|Clostridia,3WAXS@53433|Halanaerobiales 186801|Clostridia S Flavodoxin-like fold - - - - - - - - - - - - FMN_red,Flavodoxin_2,SCP2 k59_920220_3 373903.Hore_13630 7.42e-49 163.0 COG0431@1|root,COG0431@2|Bacteria,1TTVK@1239|Firmicutes,25I4H@186801|Clostridia,3WC2J@53433|Halanaerobiales 2|Bacteria S NADPH-dependent FMN reductase - - - - - - - - - - - - FAD_binding_2,FMN_bind,Flavodoxin_2,TIR_2 k59_920220_4 1540257.JQMW01000013_gene1248 0.0 1399.0 COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,25E5B@186801|Clostridia,36UMQ@31979|Clostridiaceae 186801|Clostridia C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS18410 Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_993151_2 929558.SMGD1_0558 2.67e-183 527.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit frdA - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_993151_3 944547.ABLL_0444 7.63e-16 76.6 COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,42NAY@68525|delta/epsilon subdivisions,2YMAV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase frdC - - ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_698422_2 349106.PsycPRwf_0124 9.35e-25 100.0 28IMK@1|root,2Z8N2@2|Bacteria,1R85A@1224|Proteobacteria 1224|Proteobacteria L Dam-replacing family - - 3.1.21.4 ko:K01155 - - - - ko00000,ko01000,ko02048 - - - DpnI k59_143962_1 1120705.FG95_01717 2.48e-06 54.7 COG5338@1|root,COG5338@2|Bacteria,1PFWT@1224|Proteobacteria,2U090@28211|Alphaproteobacteria,2K2PC@204457|Sphingomonadales 204457|Sphingomonadales S Putative beta-barrel porin 2 - - - - - - - - - - - - BBP2_2 k59_208790_1 913325.N799_02655 2.03e-24 107.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X5CR@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_568187_1 1168034.FH5T_07165 2.1e-108 322.0 COG0613@1|root,COG0613@2|Bacteria,4NHZ5@976|Bacteroidetes,2FQW5@200643|Bacteroidia 976|Bacteroidetes G Domain of unknown function - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - DUF5001,PHP k59_568187_2 1168034.FH5T_07170 9.84e-89 272.0 COG1940@1|root,COG1940@2|Bacteria,4NFZ1@976|Bacteroidetes,2FNEQ@200643|Bacteroidia 976|Bacteroidetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HTH_24,MarR,ROK k59_340148_1 469616.FMAG_01789 9.19e-24 102.0 COG3723@1|root,COG3723@2|Bacteria,37BPI@32066|Fusobacteria 32066|Fusobacteria L RecT family - - - - - - - - - - - - RecT k59_240689_1 242619.PG_0537 2.61e-36 139.0 COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,2FNVV@200643|Bacteroidia,22VWR@171551|Porphyromonadaceae 976|Bacteroidetes E Catalyzes the hydrolysis of Xaa-His dipeptides - - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_894590_2 96561.Dole_0174 8.68e-34 122.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2MK26@213118|Desulfobacterales 28221|Deltaproteobacteria O peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_371925_1 574375.BAGA_08020 1.39e-32 119.0 COG2963@1|root,COG2963@2|Bacteria,1V771@1239|Firmicutes,4HJ16@91061|Bacilli,1ZH8P@1386|Bacillus 91061|Bacilli L transposase activity - - - - - - - - - - - - - k59_371925_2 500633.CLOHIR_02083 5.78e-64 209.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1TRR6@1239|Firmicutes,24B89@186801|Clostridia 186801|Clostridia L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_2 k59_176264_1 202952.BBLI01000134_gene4013 2e-31 127.0 COG2911@1|root,COG3170@1|root,COG2911@2|Bacteria,COG3170@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria 1236|Gammaproteobacteria D PFAM FecR protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3 k59_305298_1 748727.CLJU_c05310 1.73e-240 670.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,36DFS@31979|Clostridiaceae 186801|Clostridia M mannose-1-phosphate guanylyltransferase - - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS00940 MannoseP_isomer,NTP_transferase k59_730794_1 1123060.JONP01000035_gene3401 4.81e-41 156.0 COG0507@1|root,COG0507@2|Bacteria,1MUTR@1224|Proteobacteria,2TSQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Conjugal transfer protein - - - - - - - - - - - - AAA_30,MobA_MobL,Relaxase,Viral_helicase1 k59_895300_1 1517681.HW45_17845 3.95e-11 61.2 COG3686@1|root,COG3686@2|Bacteria,1N8EA@1224|Proteobacteria,1S8AI@1236|Gammaproteobacteria,1XY6T@135623|Vibrionales 135623|Vibrionales S MAPEG family - - - - - - - - - - - - MAPEG k59_568759_1 1537917.JU82_02675 4.37e-73 228.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,42NRV@68525|delta/epsilon subdivisions,2YMK2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_469925_1 670307.HYPDE_26713 9.07e-191 549.0 COG1075@1|root,COG1075@2|Bacteria,1NMH0@1224|Proteobacteria,2TXVV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_43713_1 96561.Dole_0884 3.2e-140 409.0 COG2116@1|root,COG2204@1|root,COG2116@2|Bacteria,COG2204@2|Bacteria,1MU0W@1224|Proteobacteria,42Q34@68525|delta/epsilon subdivisions,2WN9I@28221|Deltaproteobacteria,2MKB5@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM formate nitrite transporter fdhC - - ko:K06212,ko:K21993 - - - - ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2 - - Form_Nir_trans,Response_reg k59_730797_1 314278.NB231_07702 1.77e-36 140.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,1RP3U@1236|Gammaproteobacteria,1WZUN@135613|Chromatiales 135613|Chromatiales L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom k59_993801_1 933262.AXAM01000096_gene2623 8.4e-189 544.0 COG3039@1|root,COG3039@2|Bacteria,1R6NB@1224|Proteobacteria,42RBZ@68525|delta/epsilon subdivisions,2WMWZ@28221|Deltaproteobacteria,2MQ2G@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_536568_1 1049564.TevJSym_bo00090 5.81e-51 178.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,1RR3N@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG2010 Cytochrome c, mono- and diheme variants nirN - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_536568_2 1049564.TevJSym_af00680 7.24e-19 80.9 2ED3M@1|root,3370H@2|Bacteria,1NB6I@1224|Proteobacteria,1SSEY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_78105_1 94122.Shewana3_1867 1.36e-12 64.7 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1SXX2@1236|Gammaproteobacteria,2QCNN@267890|Shewanellaceae 1236|Gammaproteobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_404624_1 247639.MGP2080_07072 5.9e-67 222.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_764114_1 78245.Xaut_5061 0.000926 47.8 COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_209448_1 1094715.CM001373_gene2924 4.63e-140 427.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1JCD8@118969|Legionellales 118969|Legionellales C 2-oxoglutarate dehydrogenase C-terminal sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_144652_1 469618.FVAG_01950 2.19e-60 197.0 COG2195@1|root,COG2195@2|Bacteria,379CS@32066|Fusobacteria 32066|Fusobacteria E Peptidase family M28 - - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M42 k59_601628_1 1304885.AUEY01000024_gene2722 1.41e-73 238.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2MJ61@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde dehydrogenase family - - 1.2.1.3,1.2.99.10 ko:K00128,ko:K22445 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_305995_1 290397.Adeh_3163 6.34e-44 166.0 2F2IM@1|root,33VFK@2|Bacteria,1RIX8@1224|Proteobacteria,42T5Z@68525|delta/epsilon subdivisions,2WPA9@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - Paired_CXXCH_1 k59_78109_1 439235.Dalk_4404 1.87e-37 151.0 COG3419@1|root,COG3506@1|root,COG3419@2|Bacteria,COG3506@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WKJV@28221|Deltaproteobacteria,2MHMF@213118|Desulfobacterales 28221|Deltaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,PA14 k59_340863_1 387093.SUN_1762 7.21e-45 155.0 COG1729@1|root,COG1729@2|Bacteria,1NG81@1224|Proteobacteria,42R1Z@68525|delta/epsilon subdivisions,2YNY7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S repeat protein ybgF - - - - - - - - - - - TPR_16,TPR_2,TPR_6 k59_1025329_1 765912.Thimo_2365 9.42e-113 356.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_699066_2 192952.MM_2682 2.59e-28 120.0 COG4584@1|root,arCOG02126@2157|Archaea 2157|Archaea L DNA integration - - - - - - - - - - - - HTH_7,rve k59_699066_3 1280676.AUJO01000027_gene3071 2.08e-18 89.7 COG1484@1|root,COG1484@2|Bacteria,1TRNX@1239|Firmicutes,24EVP@186801|Clostridia,4BZPJ@830|Butyrivibrio 186801|Clostridia L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_699067_2 1484460.JSWG01000001_gene2183 1.59e-12 67.4 COG3637@1|root,COG3637@2|Bacteria,4NPV9@976|Bacteroidetes,1I47X@117743|Flavobacteriia 976|Bacteroidetes M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl_2 k59_144666_1 1499689.CCNN01000006_gene764 1.31e-18 88.6 2E6M7@1|root,3317T@2|Bacteria,1UF7C@1239|Firmicutes,24KTW@186801|Clostridia,36PNE@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_144666_2 627192.SLG_22170 2.04e-29 109.0 2E9X2@1|root,3342T@2|Bacteria,1NAAT@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_306011_1 1122137.AQXF01000001_gene3201 1.77e-26 112.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,2U0ZR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF2333 k59_601644_1 1172190.M947_05860 8.02e-34 120.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2YNX4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_1025338_1 411469.EUBHAL_00332 3.07e-54 178.0 COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,247U5@186801|Clostridia,25W3M@186806|Eubacteriaceae 186801|Clostridia E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively mtnN - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_111001_1 387093.SUN_1921 1.47e-45 156.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,42ME7@68525|delta/epsilon subdivisions,2YMBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG membrane - - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA k59_111001_2 387093.SUN_1920 3.53e-20 86.7 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2YM9D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_436815_1 1121405.dsmv_0457 7.23e-44 160.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MHPE@213118|Desulfobacterales 28221|Deltaproteobacteria NU type II secretion system protein E gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1025341_1 713586.KB900536_gene617 3.26e-136 393.0 COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1X1MB@135613|Chromatiales 135613|Chromatiales I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_469955_2 1168034.FH5T_09685 3.34e-127 364.0 COG0461@1|root,COG0461@2|Bacteria,4NEF8@976|Bacteroidetes,2FMTB@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10,4.1.1.23 ko:K00762,ko:K13421 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00051 R00965,R01870,R08231 RC00063,RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase,Pribosyltran k59_469955_3 1168034.FH5T_09680 1.99e-87 258.0 COG3427@1|root,COG3427@2|Bacteria,4NUYJ@976|Bacteroidetes,2FS4N@200643|Bacteroidia 976|Bacteroidetes S Polyketide cyclase - - - - - - - - - - - - Polyketide_cyc2 k59_404653_1 797114.C475_03179 6.43e-05 52.8 COG0784@1|root,arCOG06712@1|root,arCOG02333@2157|Archaea,arCOG06712@2157|Archaea 2157|Archaea T PAS domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_177009_1 867845.KI911784_gene1508 1.33e-22 103.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3764S@32061|Chloroflexia 32061|Chloroflexia T PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,Guanylate_cyc,TPR_12,TPR_2 k59_111015_1 768671.ThimaDRAFT_2361 1.56e-76 243.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_436821_1 1168034.FH5T_20110 5.4e-76 229.0 COG0054@1|root,COG0054@2|Bacteria,4NNUC@976|Bacteroidetes,2FNGS@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_436821_2 411477.PARMER_03207 0.000879 42.0 2EGII@1|root,33AAP@2|Bacteria,4NXMZ@976|Bacteroidetes,2FVPI@200643|Bacteroidia,2314H@171551|Porphyromonadaceae 976|Bacteroidetes - - - - - - - - - - - - - - DUF4890 k59_895358_2 553219.CAMSH0001_0930 2.09e-32 127.0 COG0699@1|root,COG0699@2|Bacteria 2|Bacteria T ATPase. Has a role at an early stage in the morphogenesis of the spore coat - - - - - - - - - - - - Dynamin_N k59_993855_1 1205680.CAKO01000037_gene1192 8.76e-46 162.0 COG2114@1|root,COG2114@2|Bacteria,1R9WJ@1224|Proteobacteria,2U5T6@28211|Alphaproteobacteria,2JVCE@204441|Rhodospirillales 204441|Rhodospirillales T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_730846_1 326298.Suden_0338 5.42e-97 300.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2YMEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_634379_1 1168034.FH5T_04015 3e-102 330.0 COG4797@1|root,COG4797@2|Bacteria,4PKQS@976|Bacteroidetes,2FP69@200643|Bacteroidia 976|Bacteroidetes S Motility related/secretion protein sprA - - - - - - - - - - - SprA_N k59_895367_1 714943.Mucpa_6355 6.78e-14 75.9 COG1629@1|root,COG1629@2|Bacteria,4NMUQ@976|Bacteroidetes,1IS0V@117747|Sphingobacteriia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarboxypepD_reg,OMP_b-brl_3,Plug k59_144703_2 1537917.JU82_09880 7.33e-75 227.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,42RGH@68525|delta/epsilon subdivisions,2YP5E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_144703_3 929558.SMGD1_1872 1.41e-09 57.8 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2YMIS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_634384_1 1168034.FH5T_08175 3.02e-32 120.0 COG0016@1|root,COG0016@2|Bacteria,4NF8I@976|Bacteroidetes,2FNZN@200643|Bacteroidia 976|Bacteroidetes J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_111035_1 1123514.KB905899_gene755 1.52e-07 58.9 COG0834@1|root,COG5002@1|root,COG0834@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4 k59_568824_1 1168034.FH5T_01885 3.36e-78 234.0 COG1595@1|root,COG1595@2|Bacteria,4NMM3@976|Bacteroidetes,2FNH5@200643|Bacteroidia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily sigR_3 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_372562_1 572477.Alvin_1179 2.12e-79 244.0 COG0369@1|root,COG0369@2|Bacteria,1NCKQ@1224|Proteobacteria,1RR4U@1236|Gammaproteobacteria,1WX7N@135613|Chromatiales 135613|Chromatiales P PFAM Oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.8.1.2 ko:K00380,ko:K02641 ko00195,ko00920,ko01100,ko01120,map00195,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko00194,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_340926_1 1178825.ALIH01000004_gene2813 6.11e-52 180.0 COG3119@1|root,COG3119@2|Bacteria,4NFGI@976|Bacteroidetes,1HZQ7@117743|Flavobacteriia 976|Bacteroidetes P Sulfatase - - - - - - - - - - - - Sulfatase k59_436851_1 314285.KT71_18426 5.04e-78 251.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1J4H2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_960484_1 1168034.FH5T_01875 2.62e-33 118.0 2DEYG@1|root,2ZPSM@2|Bacteria,4NNJW@976|Bacteroidetes,2FTAK@200643|Bacteroidia 976|Bacteroidetes S COG NOG14473 non supervised orthologous group - - - - - - - - - - - - - k59_960484_2 1121904.ARBP01000007_gene3014 1.28e-05 49.7 COG4206@1|root,COG4206@2|Bacteria,4NHH8@976|Bacteroidetes,47P5E@768503|Cytophagia 976|Bacteroidetes H TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_829851_1 342113.DM82_6278 1.36e-77 270.0 COG0775@1|root,COG0775@2|Bacteria,1ND8Y@1224|Proteobacteria,2W5WW@28216|Betaproteobacteria,1KDWE@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively - - - - - - - - - - - - PNP_UDP_1 k59_272841_1 1198232.CYCME_0807 7.24e-15 76.3 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,460QS@72273|Thiotrichales 72273|Thiotrichales S TIGRFAM TIGR02099 family protein - - - - - - - - - - - - AsmA_2,DUF3971 k59_960494_1 933262.AXAM01000001_gene337 3.45e-82 251.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2MJ4H@213118|Desulfobacterales 28221|Deltaproteobacteria IQ Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_372569_1 32057.KB217478_gene171 6.23e-69 221.0 COG5433@1|root,COG5433@2|Bacteria,1G2IT@1117|Cyanobacteria 1117|Cyanobacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_794319_1 1121335.Clst_0442 1.49e-71 220.0 COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,3WJ4N@541000|Ruminococcaceae 186801|Clostridia S domain protein ymdB - - - - - - - - - - - Macro k59_601716_1 292414.TM1040_1671 7.07e-99 305.0 COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,4NCRW@97050|Ruegeria 28211|Alphaproteobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_144730_1 1408439.JHXW01000010_gene168 7.42e-47 162.0 COG0486@1|root,COG0486@2|Bacteria,378J5@32066|Fusobacteria 32066|Fusobacteria S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_144730_2 572544.Ilyop_1902 1.35e-159 465.0 COG0445@1|root,COG0445@2|Bacteria,3783J@32066|Fusobacteria 32066|Fusobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA1 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_634426_1 649747.HMPREF0083_00261 3.94e-56 196.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,26QWH@186822|Paenibacillaceae 91061|Bacilli T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9 k59_829867_2 1487921.DP68_16785 2.7e-133 383.0 COG1924@1|root,COG1924@2|Bacteria,1TQWR@1239|Firmicutes,2484G@186801|Clostridia,36DUS@31979|Clostridiaceae 186801|Clostridia I CoA-substrate-specific enzyme activase fldI1 - - - - - - - - - - - BcrAD_BadFG k59_773387_1 326298.Suden_0046 6.78e-52 175.0 COG3137@1|root,COG3137@2|Bacteria,1PWI2@1224|Proteobacteria,42W3Z@68525|delta/epsilon subdivisions,2YQX2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 k59_1034124_1 631362.Thi970DRAFT_04513 4.96e-48 177.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales 135613|Chromatiales L TIGRFAM ATP-dependent helicase HrpA - - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_904174_1 765912.Thimo_3266 2.36e-59 196.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1WVWN@135613|Chromatiales 135613|Chromatiales M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N k59_708127_2 933262.AXAM01000009_gene1482 3.76e-35 123.0 COG1246@1|root,COG1246@2|Bacteria,1RHT7@1224|Proteobacteria,42SGE@68525|delta/epsilon subdivisions,2WP91@28221|Deltaproteobacteria,2MK41@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM GCN5-related N-acetyltransferase argA - 2.3.1.1 ko:K00619 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0946 Acetyltransf_1,Acetyltransf_7 k59_577733_1 396588.Tgr7_1025 3.01e-54 188.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1WX1A@135613|Chromatiales 135613|Chromatiales T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_838739_1 1537917.JU82_00850 3.37e-137 404.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H ATP citrate synthase - - 2.3.3.8 ko:K15230 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,Ligase_CoA k59_610631_1 631454.N177_0500 7.53e-67 214.0 COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2V8Q4@28211|Alphaproteobacteria,1JQCU@119043|Rhodobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_120198_1 768671.ThimaDRAFT_3830 1.44e-98 297.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RQ04@1236|Gammaproteobacteria,1WXUZ@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_969627_1 1165841.SULAR_08100 1.21e-113 379.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind,Laminin_G_3 k59_513570_1 631454.N177_0008 9.28e-163 470.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,1JNGM@119043|Rhodobiaceae 28211|Alphaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_445853_1 1121346.KB899844_gene1005 2.15e-62 205.0 COG1653@1|root,COG1653@2|Bacteria,1U2P7@1239|Firmicutes,4HCY4@91061|Bacilli,26T3M@186822|Paenibacillaceae 91061|Bacilli G Sugar ABC transporter substrate-binding protein msmE3 - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 k59_349893_1 1121405.dsmv_2856 7.45e-90 281.0 COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_186218_1 1165841.SULAR_08107 2.49e-20 97.8 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind k59_86998_1 439235.Dalk_3763 2e-25 108.0 COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales 28221|Deltaproteobacteria KLT PFAM Protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_478722_1 1121334.KB911078_gene1168 3.05e-25 100.0 COG2057@1|root,COG2057@2|Bacteria,1UDE4@1239|Firmicutes,24B51@186801|Clostridia 186801|Clostridia I Acyl CoA acetate 3-ketoacid CoA transferase beta subunit gctB - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_478722_2 1121296.JONJ01000006_gene2197 1.07e-81 250.0 COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,2205A@1506553|Lachnoclostridium 186801|Clostridia I CoA-substrate-specific enzyme activase hgdC - - - - - - - - - - - BcrAD_BadFG k59_937460_1 1492738.FEM21_02940 1.32e-10 60.5 COG0351@1|root,COG0351@2|Bacteria,4NE0F@976|Bacteroidetes,1I2PM@117743|Flavobacteriia,2NTR8@237|Flavobacterium 976|Bacteroidetes H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_937460_2 585543.HMPREF0969_03328 1.18e-14 74.7 COG0352@1|root,COG0352@2|Bacteria,4NRDR@976|Bacteroidetes,2FNNJ@200643|Bacteroidia,4ANEB@815|Bacteroidaceae 976|Bacteroidetes H Thiamine monophosphate synthase TENI thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_870908_1 742735.HMPREF9467_03923 5.25e-250 723.0 COG1204@1|root,COG1204@2|Bacteria,1TT19@1239|Firmicutes,2494I@186801|Clostridia 186801|Clostridia L helicase - - - - - - - - - - - - DEAD,Helicase_C k59_445855_1 749222.Nitsa_0163 3.37e-101 318.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4_10,Molybdopterin,NADH-G_4Fe-4S_3 k59_545360_1 351348.Maqu_0568 5.14e-116 362.0 COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,1RQFM@1236|Gammaproteobacteria,464N1@72275|Alteromonadaceae 1236|Gammaproteobacteria L ATPase involved in DNA repair sbcC GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576,GO:1990238 - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,AAA_29,SbcCD_C k59_87004_1 398580.Dshi_3174 1.46e-28 107.0 COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2U84D@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator AsnC family nirH - - - - - - - - - - - HTH_AsnC-type k59_87004_2 292415.Tbd_0071 1.02e-80 250.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,1KSZD@119069|Hydrogenophilales 119069|Hydrogenophilales C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM k59_349904_1 153948.NAL212_0680 2.45e-59 191.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKP0@28216|Betaproteobacteria,372US@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_349904_2 1121374.KB891590_gene1690 8.25e-25 100.0 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_610666_1 243231.GSU2533 4.65e-40 148.0 COG3203@1|root,COG3203@2|Bacteria,1PJNW@1224|Proteobacteria,42TCM@68525|delta/epsilon subdivisions,2WPPQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_381408_1 395493.BegalDRAFT_2735 2.85e-32 133.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,45ZUT@72273|Thiotrichales 72273|Thiotrichales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_513589_1 1499967.BAYZ01000044_gene2991 2.69e-05 46.2 28IHG@1|root,2Z8IP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_513589_2 866895.HBHAL_3993 2.93e-36 131.0 COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,4HDT9@91061|Bacilli,3NDVC@45667|Halobacillus 91061|Bacilli K DeoR C terminal sensor domain fruR - - ko:K03436 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR k59_250333_1 62928.azo1092 5.13e-30 122.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KV42@206389|Rhodocyclales 206389|Rhodocyclales E Domain of unknown function (DUF3488) - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_969649_1 745411.B3C1_19133 3.3e-42 150.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,1J7B8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase Z012_08285 - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_349909_1 358681.BBR47_39870 1.06e-95 311.0 COG0300@1|root,COG1020@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae 91061|Bacilli Q Non-ribosomal peptide synthetase modules and related proteins pksM3 - - ko:K13611,ko:K13614,ko:K15654 ko01054,ko02024,map01054,map02024 - - - ko00000,ko00001,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_186236_1 709032.Sulku_1366 1.7e-80 259.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2YMN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA_synt_2f k59_545368_1 572544.Ilyop_0913 3.16e-135 394.0 COG0004@1|root,COG0004@2|Bacteria,37ANZ@32066|Fusobacteria 32066|Fusobacteria P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_545368_2 572544.Ilyop_0914 2.14e-47 154.0 COG0347@1|root,COG0347@2|Bacteria,37CG9@32066|Fusobacteria 32066|Fusobacteria K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_676705_1 1211114.ALIP01000160_gene1603 2.37e-91 300.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales 135614|Xanthomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_414261_1 1168034.FH5T_01140 5.76e-121 363.0 COG1115@1|root,COG1115@2|Bacteria,4NDX7@976|Bacteroidetes,2FMFZ@200643|Bacteroidia 976|Bacteroidetes E amino acid carrier protein - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_970508_1 1232410.KI421424_gene1825 6.74e-56 187.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2WJ4C@28221|Deltaproteobacteria,43SZF@69541|Desulfuromonadales 28221|Deltaproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 1.21.98.1,2.5.1.120,2.5.1.77 ko:K11779,ko:K11784,ko:K18285 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396,R10667 RC00021,RC01381,RC02329,RC03002,RC03007,RC03234 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3391 Radical_SAM k59_740484_1 1178482.BJB45_10615 1.86e-16 75.9 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1XJJN@135619|Oceanospirillales 135619|Oceanospirillales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_740484_2 1499686.BN1079_02566 6.31e-55 191.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria 1236|Gammaproteobacteria C protein containing LysM domain lysM - - - - - - - - - - - LysM k59_611495_2 765910.MARPU_11735 6.2e-55 189.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXQ0@135613|Chromatiales 135613|Chromatiales P Citrate transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_644137_1 1120999.JONM01000004_gene3659 6.61e-105 313.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KPZN@206351|Neisseriales 206351|Neisseriales F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_446643_2 411684.HPDFL43_09837 2.44e-10 63.5 COG3090@1|root,COG3090@2|Bacteria,1NCEM@1224|Proteobacteria,2UFJP@28211|Alphaproteobacteria,43MEH@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_187016_1 59374.Fisuc_0219 1.69e-43 155.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_414269_1 450851.PHZ_c1071 9.81e-151 446.0 COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,2TTR0@28211|Alphaproteobacteria,2KIG0@204458|Caulobacterales 204458|Caulobacterales M Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_611502_1 749222.Nitsa_0345 5.9e-57 186.0 COG3209@1|root,COG3209@2|Bacteria,1R0C4@1224|Proteobacteria,43CUG@68525|delta/epsilon subdivisions 1224|Proteobacteria M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - - k59_315761_1 398580.Dshi_1709 2.15e-78 250.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2U3WC@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_578478_2 1453498.LG45_13835 2.72e-46 152.0 2AR54@1|root,31GER@2|Bacteria,4NSCR@976|Bacteroidetes,1I3DE@117743|Flavobacteriia,2NWXT@237|Flavobacterium 976|Bacteroidetes J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_774204_2 1196029.ALIM01000014_gene3484 2.28e-08 62.8 COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,4HE64@91061|Bacilli,1ZBUM@1386|Bacillus 91061|Bacilli EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_774204_3 1484460.JSWG01000009_gene376 0.000736 47.4 COG0664@1|root,COG0664@2|Bacteria,4NKGK@976|Bacteroidetes,1I2MF@117743|Flavobacteriia 976|Bacteroidetes T cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - cNMP_binding k59_774204_4 903814.ELI_3920 7.66e-30 119.0 COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,25VIU@186806|Eubacteriaceae 186801|Clostridia K Psort location Cytoplasmic, score - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k59_774204_5 1286171.EAL2_c02650 2.63e-87 268.0 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,25VDW@186806|Eubacteriaceae 186801|Clostridia E histidinol phosphate phosphatase, HisJ family hisK - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP k59_53276_1 709032.Sulku_1443 2.65e-148 427.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2YMG9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0026 Citrate_synt k59_1003712_2 143224.JQMD01000002_gene1728 4.97e-83 262.0 COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,1HX4R@117743|Flavobacteriia 976|Bacteroidetes P arylsulfatase a - - - - - - - - - - - - DUF4976,Sulfatase k59_87903_1 1121013.P873_12090 5.29e-74 239.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1X8AF@135614|Xanthomonadales 135614|Xanthomonadales S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_17510_1 1506583.JQJY01000003_gene3634 2.06e-22 101.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia,2NSID@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_187050_1 1249480.B649_02455 4.04e-71 219.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,42QHV@68525|delta/epsilon subdivisions,2YNYV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S NYN domain - - - - - - - - - - - - NYN,OST-HTH k59_187050_2 929558.SMGD1_0778 2.61e-18 85.9 COG0457@1|root,COG0457@2|Bacteria,1NRB9@1224|Proteobacteria,42W0K@68525|delta/epsilon subdivisions,2YQ9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11,TPR_2,TPR_8 k59_187050_3 1172190.M947_03035 2.68e-36 135.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2YMKH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_803545_1 1159870.KB907784_gene1305 1.29e-11 70.5 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,3T32G@506|Alcaligenaceae 28216|Betaproteobacteria I carboxylase accA1 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_87920_1 709032.Sulku_1437 3.2e-10 60.1 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42QFD@68525|delta/epsilon subdivisions,2YND7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FP Ppx GppA - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_740525_1 270374.MELB17_23685 8.93e-65 211.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,464VA@72275|Alteromonadaceae 1236|Gammaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Formyl_trans_C,Formyl_trans_N k59_644177_1 272942.RCAP_rcc02973 8.29e-234 652.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,1FBD8@1060|Rhodobacter 28211|Alphaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_578511_1 321846.PS417_28540 5.27e-47 166.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_871711_1 861299.J421_0531 3.5e-62 215.0 COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria 2|Bacteria S homoserine kinase activity gabT - 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - APH,Aminotran_3,Peptidase_M23 k59_871713_1 1232437.KL661990_gene411 4.76e-37 137.0 COG0642@1|root,COG2205@2|Bacteria,1RK25@1224|Proteobacteria,42T3D@68525|delta/epsilon subdivisions,2WMAT@28221|Deltaproteobacteria,2MI6G@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA k59_315812_1 1071679.BG57_07865 3.87e-82 270.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae 28216|Betaproteobacteria V Efflux pump membrane transporter - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_282318_1 2340.JV46_20250 3.04e-76 235.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1J5PU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_187061_1 1168034.FH5T_18320 3.26e-151 438.0 COG1757@1|root,COG1757@2|Bacteria,4NFQT@976|Bacteroidetes,2FNIY@200643|Bacteroidia 976|Bacteroidetes C Na H antiporter nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k59_120908_1 452637.Oter_4173 1.71e-71 224.0 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU,PEMT k59_774232_1 268739.Nmlp_1695 1.07e-29 127.0 COG0417@1|root,COG1372@1|root,arCOG00328@2157|Archaea,arCOG03145@2157|Archaea,2XU1K@28890|Euryarchaeota,23RXE@183963|Halobacteria 183963|Halobacteria L COG0417 DNA polymerase elongation subunit (family B) polB1 - 2.7.7.7 ko:K02319 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032 - - - DNA_pol_B,DNA_pol_B_exo1,Intein_splicing k59_611546_1 1000565.METUNv1_03030 1.04e-12 73.9 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,2VKWX@28216|Betaproteobacteria,2KW3I@206389|Rhodocyclales 206389|Rhodocyclales I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_315815_1 981085.XP_010099133.1 4.41e-120 360.0 COG0129@1|root,KOG2448@2759|Eukaryota,37R9I@33090|Viridiplantae,3GBHF@35493|Streptophyta,4JK7Z@91835|fabids 35493|Streptophyta E Dihydroxy-acid dehydratase - GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006807,GO:0006950,GO:0006970,GO:0007275,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009507,GO:0009532,GO:0009536,GO:0009553,GO:0009555,GO:0009570,GO:0009628,GO:0009651,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0022622,GO:0032501,GO:0032502,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0050896,GO:0071704,GO:0099402,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_315816_1 1298593.TOL_1967 1.48e-54 189.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1XIGR@135619|Oceanospirillales 135619|Oceanospirillales I Acyltransferase - - - - - - - - - - - - Acyltransferase,MFS_1 k59_514479_1 1049564.TevJSym_bb00080 3.85e-119 343.0 COG1152@1|root,COG1152@2|Bacteria,1R9TR@1224|Proteobacteria 1224|Proteobacteria C 2Fe-2S iron-sulfur cluster binding domain protein - - - - - - - - - - - - Fer2,Fer2_4,Fer4_10,Fer4_9 k59_514479_2 1049564.TevJSym_bb00070 1.62e-284 790.0 COG0029@1|root,COG0029@2|Bacteria,1QY0Z@1224|Proteobacteria 1224|Proteobacteria C FAD binding domain - - 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00278 ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00115,M00149,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_514479_3 1049564.TevJSym_bb00060 5.09e-219 613.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1J4GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF2 - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_976588_2 1280698.AUJS01000015_gene310 5.01e-38 131.0 COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,24JDC@186801|Clostridia,27VK2@189330|Dorea 186801|Clostridia J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_288864_2 631362.Thi970DRAFT_01929 2.43e-11 63.9 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_878103_1 1249627.D779_1588 6.64e-49 171.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1WWCY@135613|Chromatiales 135613|Chromatiales G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_127068_1 670307.HYPDE_23013 1.87e-52 175.0 COG4221@1|root,COG4221@2|Bacteria,1QVS5@1224|Proteobacteria 1224|Proteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_454395_1 880071.Fleli_0252 4.57e-30 125.0 COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,47KKB@768503|Cytophagia 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_1042021_2 866771.HMPREF9296_0030 1.67e-13 70.9 COG3108@1|root,COG3108@2|Bacteria,4NW30@976|Bacteroidetes,2FUXK@200643|Bacteroidia 976|Bacteroidetes S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_454397_1 2340.JV46_29040 5.36e-61 203.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1J4T7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662 - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iPC815.YPO3762,iSFV_1184.SFV_3651 TrkH k59_59888_1 857087.Metme_1324 1.64e-25 102.0 COG0664@1|root,COG0664@2|Bacteria,1QK2K@1224|Proteobacteria,1TI5A@1236|Gammaproteobacteria,1XGJ2@135618|Methylococcales 135618|Methylococcales K Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_257574_1 933262.AXAM01000077_gene1703 1.37e-86 268.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria,2MJ2C@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_845389_1 365046.Rta_18970 1.03e-11 72.4 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,4A9WS@80864|Comamonadaceae 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_780888_1 1255043.TVNIR_0224 3.15e-39 140.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1WX8X@135613|Chromatiales 135613|Chromatiales C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_780888_2 1117647.M5M_14717 1.85e-38 145.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1J4BX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_618266_1 395494.Galf_0781 1.65e-96 312.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,2WGI2@28216|Betaproteobacteria,44VD9@713636|Nitrosomonadales 28216|Betaproteobacteria EI Carbamoyl-phosphate synthetase large chain domain protein uca - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_944715_1 317025.Tcr_1993 5.69e-73 234.0 COG0348@1|root,COG0348@2|Bacteria,1N605@1224|Proteobacteria,1RNU6@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG0348 Polyferredoxin - - - - - - - - - - - - Fer4_5 k59_288876_1 1117318.PRUB_06050 7.67e-45 153.0 2BVTQ@1|root,2Z7J9@2|Bacteria,1P01Z@1224|Proteobacteria,1RNNB@1236|Gammaproteobacteria,2Q16W@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF2797) LA2027 - - - - - - - - - - - DUF2797 k59_746423_1 1049564.TevJSym_aa01860 8.77e-95 282.0 COG1051@1|root,COG1051@2|Bacteria,1QTT4@1224|Proteobacteria,1RQ35@1236|Gammaproteobacteria,1J69Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG1051 ADP-ribose pyrophosphatase nuhA - - - - - - - - - - - NUDIX k59_683521_1 709032.Sulku_1436 0.000236 42.7 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2YNDC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_683521_2 1249480.B649_05555 8.08e-131 387.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2YMJV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_585354_1 1121106.JQKB01000012_gene4650 4.25e-05 46.2 COG0642@1|root,COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JQR3@204441|Rhodospirillales 204441|Rhodospirillales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg k59_585354_2 1049564.TevJSym_ab00160 4.64e-98 290.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1J64K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1009621_1 102125.Xen7305DRAFT_00033600 6.36e-08 50.4 COG2026@1|root,COG2026@2|Bacteria,1GKH4@1117|Cyanobacteria,3VN3E@52604|Pleurocapsales 1117|Cyanobacteria DJ PFAM Plasmid stabilisation system protein - - - - - - - - - - - - ParE_toxin k59_257586_1 385682.AFSL01000014_gene2769 9.17e-177 506.0 COG2461@1|root,COG2461@2|Bacteria,4NJQA@976|Bacteroidetes,2FMK7@200643|Bacteroidia,3XKFV@558415|Marinilabiliaceae 976|Bacteroidetes S PAS domain - - - ko:K09155 - - - - ko00000 - - - DUF1858,DUF438,Hemerythrin,PAS_10 k59_257586_2 385682.AFSL01000014_gene2770 1.52e-35 127.0 COG4309@1|root,COG4309@2|Bacteria,4NQP0@976|Bacteroidetes,2FUI1@200643|Bacteroidia,3XKFI@558415|Marinilabiliaceae 976|Bacteroidetes S Domain of unknown function (DUF1858) - - - - - - - - - - - - DUF1858,DUF2249 k59_193705_1 1249480.B649_01625 6.66e-62 207.0 COG2203@1|root,COG2206@1|root,COG3829@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3829@2|Bacteria,1RAQS@1224|Proteobacteria,42QQI@68525|delta/epsilon subdivisions 1224|Proteobacteria T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - CBS,GAF,GAF_2,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9,Response_reg,sCache_2 k59_193705_2 864069.MicloDRAFT_00001350 2.18e-06 55.1 COG3920@1|root,COG5002@1|root,COG3920@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,GGDEF,HATPase_c,HATPase_c_2,HWE_HK,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_225962_1 1163617.SCD_n02931 3.04e-22 97.4 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,2VS6Y@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N k59_809630_1 2340.JV46_25690 1.55e-42 145.0 COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,1S5YP@1236|Gammaproteobacteria,1J66I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 fkpB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03774 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_521054_1 931627.MycrhDRAFT_5146 1.24e-27 117.0 COG0764@1|root,COG3321@1|root,COG0764@2|Bacteria,COG3321@2|Bacteria,2GIVM@201174|Actinobacteria,235ES@1762|Mycobacteriaceae 201174|Actinobacteria IQ FabA-like domain - - - - - - - - - - - - Acyl_transf_1,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt k59_845410_1 331869.BAL199_05424 4.72e-52 187.0 COG1216@1|root,COG3551@1|root,COG1216@2|Bacteria,COG3551@2|Bacteria,1MX5Z@1224|Proteobacteria,2U0IP@28211|Alphaproteobacteria,4BSHK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Glycosyltransferase like family - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_59911_1 313606.M23134_02753 3.57e-21 95.9 COG2124@1|root,COG2124@2|Bacteria,4NG9Z@976|Bacteroidetes,47KN0@768503|Cytophagia 976|Bacteroidetes Q Cytochrome P450 - - - - - - - - - - - - p450 k59_683527_1 596151.DesfrDRAFT_2501 3.29e-77 242.0 COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,42NAT@68525|delta/epsilon subdivisions,2WPPB@28221|Deltaproteobacteria,2MBTW@213115|Desulfovibrionales 28221|Deltaproteobacteria V Biotin-lipoyl like - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_127116_1 1121405.dsmv_1458 5.99e-141 414.0 COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria,2MI0B@213118|Desulfobacterales 28221|Deltaproteobacteria I Carboxyl transferase domain gcdA - 4.1.1.70 ko:K01615 ko00362,ko00650,ko01120,map00362,map00650,map01120 - R03028 RC00832 ko00000,ko00001,ko01000,ko02000 3.B.1.1.3 - - Carboxyl_trans k59_553297_1 1296415.JACC01000020_gene3830 1.11e-127 372.0 2DBF7@1|root,2Z8X0@2|Bacteria,4NKUI@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_127120_1 631362.Thi970DRAFT_01027 3.34e-89 280.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1WW1S@135613|Chromatiales 135613|Chromatiales V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_420300_1 765914.ThisiDRAFT_0107 1.91e-101 312.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales 135613|Chromatiales G PFAM Alpha amylase, catalytic - - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_715333_1 760117.JN27_07095 3.03e-102 314.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2WA04@28216|Betaproteobacteria,47500@75682|Oxalobacteraceae 28216|Betaproteobacteria E Peptidase dimerisation domain - - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_127126_2 1168034.FH5T_07890 6.98e-65 206.0 2C1B9@1|root,32R9M@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4292) - - - - - - - - - - - - DUF4292 k59_389884_1 1367847.JCM7686_0379 2.24e-20 89.4 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2TR90@28211|Alphaproteobacteria,2PVR1@265|Paracoccus 28211|Alphaproteobacteria S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_193724_1 1121405.dsmv_0405 7.24e-61 204.0 COG1183@1|root,COG1183@2|Bacteria,1MYK9@1224|Proteobacteria,42RFD@68525|delta/epsilon subdivisions 1224|Proteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA2 - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_650356_1 768671.ThimaDRAFT_4701 1.32e-106 335.0 COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_1009644_1 1121441.AUCX01000007_gene1221 6.49e-41 148.0 2CIBN@1|root,317WZ@2|Bacteria,1PZDK@1224|Proteobacteria,431JY@68525|delta/epsilon subdivisions,2WWUN@28221|Deltaproteobacteria,2MBWQ@213115|Desulfovibrionales 28221|Deltaproteobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_94181_1 1121447.JONL01000002_gene1996 5.13e-58 194.0 COG4782@1|root,COG4782@2|Bacteria,1PSSD@1224|Proteobacteria,430S8@68525|delta/epsilon subdivisions,2WW3H@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Alpha/beta hydrolase of unknown function (DUF900) - - - - - - - - - - - - DUF900 k59_161608_1 1249480.B649_04630 1.42e-87 264.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2YP5V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NOU Peptidase A24 pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_161608_2 929558.SMGD1_2848 1.21e-116 338.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2YNEP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_161608_3 1249480.B649_04640 2.75e-206 582.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2YMX4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_161608_4 929558.SMGD1_2815 2.5e-64 209.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2YMK9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase k59_976651_1 1537915.JU57_09230 0.0 2019.0 COG1403@1|root,COG1403@2|Bacteria,1R776@1224|Proteobacteria,42Z0Z@68525|delta/epsilon subdivisions,2YR1N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V HNH nucleases - - - - - - - - - - - - - k59_976651_2 1537915.JU57_09235 3.16e-181 511.0 COG1518@1|root,COG1518@2|Bacteria,1QWQZ@1224|Proteobacteria,43BVC@68525|delta/epsilon subdivisions,2YPYJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k59_976651_3 742821.HMPREF9464_01126 1.56e-10 58.5 COG1343@1|root,COG1343@2|Bacteria,1NJM8@1224|Proteobacteria,2WIFN@28216|Betaproteobacteria,4PRCJ@995019|Sutterellaceae 28216|Betaproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - - - - - - - - - - CRISPR_Cas2 k59_911179_1 326298.Suden_1373 2.11e-146 421.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2YMAU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_585395_1 1121094.KB894661_gene2742 1.84e-38 148.0 COG4775@1|root,COG4775@2|Bacteria,4NE80@976|Bacteroidetes,2G3E0@200643|Bacteroidia,4AV68@815|Bacteroidaceae 976|Bacteroidetes M Outer membrane protein, OMP85 family - - - - - - - - - - - - Bac_surface_Ag k59_650368_1 387093.SUN_2356 1.35e-104 318.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_127152_1 1168034.FH5T_18345 5.34e-61 198.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups gpgS - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_127152_2 1168034.FH5T_18350 1.38e-22 95.9 COG0438@1|root,COG0438@2|Bacteria,4P01C@976|Bacteroidetes 976|Bacteroidetes M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_1 k59_1042075_1 1380354.JIAN01000005_gene2181 1.83e-114 338.0 COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4F0KG@85016|Cellulomonadaceae 201174|Actinobacteria C Dehydrogenase E1 component pdhA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K00166 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_746450_1 1434325.AZQN01000004_gene1524 8.88e-17 88.2 COG0644@1|root,COG0644@2|Bacteria,4NJ0Z@976|Bacteroidetes,47P3F@768503|Cytophagia 976|Bacteroidetes C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_oxidored k59_553329_2 1279019.ARQK01000061_gene1812 8.61e-26 96.7 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1WZBU@135613|Chromatiales 135613|Chromatiales J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_553329_3 1049564.TevJSym_ad00080 4.62e-40 135.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1J5XE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Translation initiation factor infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_845473_1 6669.EFX76384 1.2e-46 169.0 2CXMC@1|root,2RYDR@2759|Eukaryota,3A2BI@33154|Opisthokonta,3BR3J@33208|Metazoa,3D7A1@33213|Bilateria 33208|Metazoa G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - 3.2.1.78 ko:K19355 ko00051,map00051 - R01332 RC00467 ko00000,ko00001,ko01000 - - - Cellulase k59_127172_1 357804.Ping_1904 1.78e-16 73.9 COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1SGF3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_161627_1 203122.Sde_1355 4.73e-72 242.0 COG2304@1|root,COG2304@2|Bacteria,1MVJ2@1224|Proteobacteria,1RMUF@1236|Gammaproteobacteria,464I4@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - VWA,VWA_3 k59_976684_1 1391647.AVSV01000003_gene1456 2.34e-18 93.6 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,36DSG@31979|Clostridiaceae 186801|Clostridia T response regulator - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg k59_389907_1 1283300.ATXB01000001_gene1129 1.66e-126 374.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria 1236|Gammaproteobacteria E belongs to the aspartokinase family thrA GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K12524,ko:K12525 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0002,iEcDH1_1363.EcDH1_3594,iSFV_1184.SFV_0001,iUMNK88_1353.UMNK88_4778,iYL1228.KPN_04234 AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_389907_2 224324.aq_540 7.59e-18 82.0 COG2095@1|root,COG2095@2|Bacteria,2G4VC@200783|Aquificae 200783|Aquificae U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_193772_1 1165841.SULAR_06653 6.41e-77 243.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2YMPK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_683562_1 765911.Thivi_0537 2.46e-37 138.0 COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,1S13M@1236|Gammaproteobacteria,1WWSG@135613|Chromatiales 135613|Chromatiales S PFAM Alpha beta hydrolase of - - - - - - - - - - - - DUF900 k59_683562_2 768671.ThimaDRAFT_1050 2.92e-19 80.9 2ENM6@1|root,33G8J@2|Bacteria,1NI7V@1224|Proteobacteria,1SHH5@1236|Gammaproteobacteria,1WZNB@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_683562_3 1038860.AXAP01000011_gene192 5.23e-48 160.0 COG4803@1|root,COG4803@2|Bacteria,1RAJ2@1224|Proteobacteria,2U6M7@28211|Alphaproteobacteria,3JU96@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1269) - - - - - - - - - - - - DUF1269 k59_845484_1 526218.Sterm_3781 8.89e-167 477.0 COG1454@1|root,COG1454@2|Bacteria,3792I@32066|Fusobacteria 2|Bacteria C PFAM Iron-containing alcohol dehydrogenase - - 1.1.99.37,1.2.98.1 ko:K17067 ko00625,ko00680,ko01120,ko01200,map00625,map00680,map01120,map01200 - R00614 RC00034,RC00188 ko00000,ko00001,ko01000 - - - Fe-ADH k59_288931_2 1168034.FH5T_05120 3.58e-54 169.0 COG0254@1|root,COG0254@2|Bacteria,4NS7P@976|Bacteroidetes,2FTUG@200643|Bacteroidia 976|Bacteroidetes J 50S ribosomal protein L31 type B rpmE2 - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_59995_2 1121405.dsmv_2547 6.4e-23 100.0 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2MIIC@213118|Desulfobacterales 28221|Deltaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA k59_485438_1 563040.Saut_0587 4.78e-100 313.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2YMJY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1g k59_127200_1 1026882.MAMP_02483 2.8e-72 223.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,460GC@72273|Thiotrichales 72273|Thiotrichales S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_976700_1 572544.Ilyop_2848 1.16e-229 648.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,37C26@32066|Fusobacteria 32066|Fusobacteria P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily - - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - GTP_EFTU k59_553342_1 1121896.JMLU01000033_gene2846 1.17e-97 306.0 COG2189@1|root,COG2189@2|Bacteria,4NFKE@976|Bacteroidetes,1HYXQ@117743|Flavobacteriia,2NVQN@237|Flavobacterium 976|Bacteroidetes L DNA methylase - - 2.1.1.72 ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase,TypeIII_RM_meth k59_553342_2 929558.SMGD1_1989 2.13e-104 319.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MB3@68525|delta/epsilon subdivisions,2YN95@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF4172) - - - - - - - - - - - - DUF4172,Fic k59_1042109_1 639283.Snov_3499 1.51e-42 154.0 COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,2TUW4@28211|Alphaproteobacteria,3F18Q@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Protein of unknown function DUF111 - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_258327_7 1319815.HMPREF0202_02216 1.34e-57 193.0 COG1653@1|root,COG1653@2|Bacteria,379A1@32066|Fusobacteria 32066|Fusobacteria G Bacterial extracellular solute-binding protein - - - ko:K10192 ko02010,map02010 M00202 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.11 - - SBP_bac_8 k59_390642_1 1168034.FH5T_18240 7.06e-33 125.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,2FMBN@200643|Bacteroidia 976|Bacteroidetes I Biotin carboxylase accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K01965 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_390642_2 1410608.JNKX01000014_gene654 1.91e-34 125.0 COG4770@1|root,COG4770@2|Bacteria,4NQ86@976|Bacteroidetes,2FNTU@200643|Bacteroidia,4AMGT@815|Bacteroidaceae 976|Bacteroidetes I Biotin-requiring enzyme - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl k59_522117_1 1190606.AJYG01000004_gene833 4.39e-40 146.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1XSAE@135623|Vibrionales 135623|Vibrionales H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_420942_1 1168034.FH5T_01000 3.89e-115 354.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE4N@976|Bacteroidetes,2FQUA@200643|Bacteroidia 976|Bacteroidetes C Dehydrogenase E1 component - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_322108_1 1123377.AUIV01000002_gene1133 9.43e-13 68.6 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1X47P@135614|Xanthomonadales 135614|Xanthomonadales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_322108_2 1288494.EBAPG3_4350 1.13e-14 74.7 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,372E8@32003|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_787708_1 395493.BegalDRAFT_0154 2.25e-112 348.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,45ZRI@72273|Thiotrichales 72273|Thiotrichales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_101495_1 572544.Ilyop_1505 5.33e-126 370.0 COG1243@1|root,COG1243@2|Bacteria,378Q1@32066|Fusobacteria 32066|Fusobacteria BK Radical_SAM C-terminal domain - - - - - - - - - - - - Radical_SAM,Radical_SAM_C k59_101495_2 572544.Ilyop_1506 7.63e-112 327.0 COG0571@1|root,COG0571@2|Bacteria,378UZ@32066|Fusobacteria 32066|Fusobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_101495_3 572544.Ilyop_1507 3.91e-257 709.0 COG0304@1|root,COG0304@2|Bacteria,378D2@32066|Fusobacteria 32066|Fusobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_101495_4 888055.HMPREF9015_01714 2.01e-31 112.0 COG0236@1|root,COG0236@2|Bacteria,37AM1@32066|Fusobacteria 32066|Fusobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_101495_5 1461577.CCMH01000004_gene1188 1.07e-34 126.0 COG1028@1|root,COG1028@2|Bacteria,4NEAI@976|Bacteroidetes,1HXDZ@117743|Flavobacteriia 976|Bacteroidetes IQ reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_657504_2 2340.JV46_08070 1.06e-59 197.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1J54W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - iZ_1308.Z4900 Pyr_redox_2,Pyr_redox_dim k59_35595_1 387093.SUN_0131 2.18e-92 301.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2YMMS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_559325_2 709032.Sulku_1310 6.41e-17 81.3 COG1956@1|root,COG3604@1|root,COG1956@2|Bacteria,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2YNEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF_2,HTH_8,Sigma54_activat k59_624352_1 1537917.JU82_11855 1.33e-229 654.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2YMJY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1g k59_362748_1 1160707.AJIK01000001_gene276 7.41e-05 44.3 COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,4H9RK@91061|Bacilli,26CY1@186818|Planococcaceae 91061|Bacilli NU COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_362748_2 1321779.HMPREF1984_00868 5.54e-90 275.0 COG1968@1|root,COG1968@2|Bacteria,378JX@32066|Fusobacteria 32066|Fusobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_362748_3 572544.Ilyop_0246 3.82e-189 531.0 COG0451@1|root,COG0451@2|Bacteria,3788X@32066|Fusobacteria 32066|Fusobacteria GM Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_362748_4 398511.BpOF4_19180 4.2e-47 166.0 COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,4HB6B@91061|Bacilli,1ZDNY@1386|Bacillus 91061|Bacilli S DNA polymerase alpha chain like domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_362748_5 572544.Ilyop_0242 6.5e-27 105.0 2CDFI@1|root,2ZANH@2|Bacteria,379UQ@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_297337_1 335541.Swol_2258 8.66e-267 753.0 COG0286@1|root,COG0286@2|Bacteria,1TPGZ@1239|Firmicutes,247RY@186801|Clostridia,42KQ3@68298|Syntrophomonadaceae 186801|Clostridia L HsdM N-terminal domain hsdM1 - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_395629_1 760154.Sulba_1598 4.41e-138 412.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M0P@68525|delta/epsilon subdivisions,2YMU0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P heavy metal translocating P-type ATPase - - - - - - - - - - - - E1-E2_ATPase,Hydrolase k59_297338_1 1121405.dsmv_2017 1.59e-48 165.0 COG2221@1|root,COG2221@2|Bacteria,1R5F8@1224|Proteobacteria,42PB3@68525|delta/epsilon subdivisions,2WKJR@28221|Deltaproteobacteria,2MHQY@213118|Desulfobacterales 28221|Deltaproteobacteria C Proto-chlorophyllide reductase 57 kD subunit - - - - - - - - - - - - Fer4,Fer4_6,Fer4_7,NIR_SIR,PCP_red k59_787728_1 1249627.D779_0440 6.94e-17 84.0 COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2FP@1236|Gammaproteobacteria,1WWXW@135613|Chromatiales 135613|Chromatiales C PFAM 2Fe-2S iron-sulfur cluster binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2 k59_951457_2 519989.ECTPHS_06672 2.89e-132 389.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1WX1N@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_624367_1 387092.NIS_1842 1.48e-20 90.5 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,42PMY@68525|delta/epsilon subdivisions,2YMBR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_624367_2 709032.Sulku_2508 9.41e-44 146.0 COG1314@1|root,COG1314@2|Bacteria,1NJ1D@1224|Proteobacteria,42TKW@68525|delta/epsilon subdivisions,2YPUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Preprotein translocase subunit SecG secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_167096_1 572544.Ilyop_0752 1.38e-59 205.0 COG0383@1|root,COG0383@2|Bacteria,3798P@32066|Fusobacteria 32066|Fusobacteria G hydrolase family 38 - - 3.2.1.170 ko:K15524 - - - - ko00000,ko01000 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C k59_167096_2 469618.FVAG_01751 9.72e-27 101.0 COG2190@1|root,COG2190@2|Bacteria,37A1G@32066|Fusobacteria 32066|Fusobacteria G PTS system crr - - ko:K02777 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1 - - PTS_EIIA_1 k59_101530_1 317619.ANKN01000126_gene3251 2.86e-10 65.5 COG1216@1|root,COG1216@2|Bacteria,1G48C@1117|Cyanobacteria 1117|Cyanobacteria S Glycosyl transferase, family 2 - - - - - - - - - - - - - k59_101530_2 1082931.KKY_577 0.000703 42.4 COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,3N6WV@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Belongs to the SOS response-associated peptidase family MA20_42060 - - - - - - - - - - - SRAP k59_362765_1 391038.Bphy_2868 2.52e-41 155.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1K37E@119060|Burkholderiaceae 28216|Betaproteobacteria C oxidoreductase porG - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_330461_1 1537917.JU82_10885 4.22e-76 234.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2YN6R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_232198_1 1089553.Tph_c08490 6.12e-41 142.0 COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,42GE6@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04225 Formyl_trans_N k59_232198_2 1121440.AUMA01000003_gene3082 6.55e-29 110.0 COG0384@1|root,COG0384@2|Bacteria,1R9X4@1224|Proteobacteria,42QYJ@68525|delta/epsilon subdivisions,2WN82@28221|Deltaproteobacteria,2M9IZ@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Phenazine biosynthesis PhzC PhzF protein - - - - - - - - - - - - PhzC-PhzF k59_722423_1 1227268.HMPREF1552_01129 0.0 1041.0 COG0058@1|root,COG0058@2|Bacteria,378HK@32066|Fusobacteria 32066|Fusobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_722423_2 572544.Ilyop_1282 1.57e-29 107.0 COG0762@1|root,COG0762@2|Bacteria,37AZK@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 9.82 - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_722423_3 572479.Hprae_1622 2.8e-58 193.0 COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,247SR@186801|Clostridia,3WAMC@53433|Halanaerobiales 186801|Clostridia E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_722423_4 1408439.JHXW01000001_gene1917 9.11e-66 206.0 COG0558@1|root,COG0558@2|Bacteria,3793M@32066|Fusobacteria 32066|Fusobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_722423_5 572544.Ilyop_1284 5.08e-128 376.0 COG0621@1|root,COG0621@2|Bacteria,379IJ@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_657536_1 425104.Ssed_1377 1.28e-62 206.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,1S3TH@1236|Gammaproteobacteria,2QAZF@267890|Shewanellaceae 1236|Gammaproteobacteria I PFAM Alpha beta hydrolase fold-3 domain protein aes - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_493758_1 1537917.JU82_10910 2.97e-84 272.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 k59_690265_13 2340.JV46_21860 0.0 1689.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1J4ZR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_690265_14 868864.Dester_0445 3.84e-247 697.0 COG1053@1|root,COG1053@2|Bacteria,2G3PJ@200783|Aquificae 200783|Aquificae C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein sdhA - 1.3.1.6,1.3.5.1,1.3.5.4 ko:K00239,ko:K18556 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R00402,R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_690265_15 517418.Ctha_0163 1.11e-27 112.0 COG0479@1|root,COG0479@2|Bacteria,1FDNF@1090|Chlorobi 1090|Chlorobi C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein - - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_919540_1 1168034.FH5T_05290 2.27e-100 308.0 COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,2FPVW@200643|Bacteroidia 976|Bacteroidetes G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Fucosidase_C k59_199767_1 639030.JHVA01000001_gene2744 3.5e-86 266.0 COG1408@1|root,COG1408@2|Bacteria 2|Bacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos,Metallophos_2 k59_755304_1 316273.XCV3195 2.12e-07 49.7 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1X6DR@135614|Xanthomonadales 135614|Xanthomonadales E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_755304_2 1049564.TevJSym_ao00030 6.74e-168 479.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1J4G7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glycine cleavage system T protein gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_2953 GCV_T,GCV_T_C k59_853794_1 797304.Natgr_1174 1.29e-08 55.1 COG0652@1|root,arCOG06301@1|root,arCOG04767@2157|Archaea,arCOG06301@2157|Archaea,2XTHC@28890|Euryarchaeota,23V5W@183963|Halobacteria 183963|Halobacteria O COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family ppiA - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_559891_1 289376.THEYE_A0511 5.81e-33 118.0 COG1504@1|root,COG1504@2|Bacteria 2|Bacteria L Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 k59_559891_3 1414720.CBYM010000024_gene2104 2.11e-101 307.0 COG4189@1|root,COG4189@2|Bacteria,1TPGD@1239|Firmicutes,248UW@186801|Clostridia,36EKR@31979|Clostridiaceae 186801|Clostridia K transcriptional regulator, ArsR family - - - - - - - - - - - - HTH_20,HTH_5 k59_1017107_1 1211112.ALJC01000135_gene3371 2.83e-25 105.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S permease lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1017107_2 2340.JV46_19780 6.75e-16 78.2 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1J4YI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Predicted permease YjgP/YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_461927_3 699218.HMPREF0889_0474 6.33e-07 52.8 COG1187@1|root,COG1187@2|Bacteria,1TQZ2@1239|Firmicutes,4H4VX@909932|Negativicutes 909932|Negativicutes J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_396177_1 176652.289L_IIV6 4.58e-75 239.0 4QAPV@10239|Viruses,4QV7H@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA binding - - - - - - - - - - - - - k59_428450_1 933262.AXAM01000067_gene851 2.51e-34 125.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,42RFR@68525|delta/epsilon subdivisions,2WJYK@28221|Deltaproteobacteria,2MIFF@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF1732) yicC - - - - - - - - - - - DUF1732,YicC_N k59_951865_1 572544.Ilyop_0019 3.02e-102 304.0 COG4658@1|root,COG4658@2|Bacteria,378EB@32066|Fusobacteria 32066|Fusobacteria C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_951865_2 469616.FMAG_02220 3.24e-60 192.0 COG4659@1|root,COG4659@2|Bacteria,379S6@32066|Fusobacteria 32066|Fusobacteria C Part of a membrane complex involved in electron transport rnfG - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_951865_3 572544.Ilyop_0021 4.7e-93 277.0 COG4660@1|root,COG4660@2|Bacteria,379NB@32066|Fusobacteria 32066|Fusobacteria C Part of a membrane complex involved in electron transport rnfE - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_951865_4 572544.Ilyop_0022 8.22e-111 321.0 COG4657@1|root,COG4657@2|Bacteria,3783Q@32066|Fusobacteria 32066|Fusobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_951865_5 572544.Ilyop_0023 1.28e-112 337.0 COG1142@1|root,COG2878@1|root,COG1142@2|Bacteria,COG2878@2|Bacteria,378T9@32066|Fusobacteria 32066|Fusobacteria C Putative Fe-S cluster rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_1017116_1 1123073.KB899242_gene1703 1.38e-66 209.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1X304@135614|Xanthomonadales 135614|Xanthomonadales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_167769_1 472759.Nhal_1481 1.16e-126 373.0 COG2403@1|root,COG2403@2|Bacteria,1MV4C@1224|Proteobacteria 1224|Proteobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - - k59_167770_2 385682.AFSL01000015_gene2669 1.64e-14 74.3 COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,4PKV1@976|Bacteroidetes,2G0DA@200643|Bacteroidia,3XIKT@558415|Marinilabiliaceae 976|Bacteroidetes T PAS fold - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_199786_1 1191523.MROS_2851 1.57e-26 103.0 COG2172@1|root,COG2172@2|Bacteria 2|Bacteria T sigma factor antagonist activity rsbW - 2.7.11.1 ko:K04757,ko:K06379,ko:K08282,ko:K17752 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 k59_199786_2 1121285.AUFK01000013_gene2207 9.95e-52 168.0 COG0319@1|root,COG0319@2|Bacteria,4NS93@976|Bacteroidetes,1I2W7@117743|Flavobacteriia,3ZRQR@59732|Chryseobacterium 976|Bacteroidetes S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - - - - - - - - - - UPF0054 k59_199786_3 1168034.FH5T_07815 3.98e-31 120.0 COG0445@1|root,COG0445@2|Bacteria,4NFNH@976|Bacteroidetes,2FMA5@200643|Bacteroidia 976|Bacteroidetes D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_624919_1 765913.ThidrDRAFT_3347 8.4e-17 76.3 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales 135613|Chromatiales E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_624919_2 1049564.TevJSym_ax00220 1.75e-64 200.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1JAG9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Redoxin bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_951866_2 1168034.FH5T_20335 4.34e-61 189.0 COG0023@1|root,COG0023@2|Bacteria,4NS6M@976|Bacteroidetes,2FTIA@200643|Bacteroidia 976|Bacteroidetes J Translation initiation factor - - - ko:K03113 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - SUI1 k59_951866_3 1121451.DESAM_22331 2.92e-37 132.0 COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,42T7R@68525|delta/epsilon subdivisions,2WNQ2@28221|Deltaproteobacteria,2MBB8@213115|Desulfovibrionales 28221|Deltaproteobacteria S family UPF0066 - - - - - - - - - - - - UPF0066 k59_331066_1 563040.Saut_0584 7e-139 407.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2YM9I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_265002_1 929558.SMGD1_1549 2.52e-30 125.0 COG4773@1|root,COG4773@2|Bacteria,1PP2I@1224|Proteobacteria,42WFP@68525|delta/epsilon subdivisions,2YQM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD k59_984367_1 1408287.AXUR01000012_gene2233 1.72e-71 231.0 COG0554@1|root,COG0554@2|Bacteria,3799Z@32066|Fusobacteria 32066|Fusobacteria H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_36151_1 1319815.HMPREF0202_02589 1.43e-63 214.0 COG0272@1|root,COG0272@2|Bacteria,3793I@32066|Fusobacteria 32066|Fusobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_36151_2 572544.Ilyop_0241 1.24e-05 46.2 COG0653@1|root,COG0653@2|Bacteria,378NS@32066|Fusobacteria 32066|Fusobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_527211_1 1168034.FH5T_09195 3.23e-13 68.9 COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,2FM1K@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug k59_232758_1 1101189.AQUO01000001_gene2681 8.83e-44 144.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria,2PWXK@265|Paracoccus 28211|Alphaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_232758_2 272942.RCAP_rcc00303 4.86e-55 172.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria,1FBUT@1060|Rhodobacter 28211|Alphaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_885980_1 1120953.AUBH01000008_gene205 1.68e-154 451.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,464A5@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component dctM - - - - - - - - - - - DctM k59_885980_2 1345697.M493_10710 5.7e-15 76.3 COG3090@1|root,COG3090@2|Bacteria,1VBG4@1239|Firmicutes,4HHAW@91061|Bacilli 91061|Bacilli G C4-dicarboxylate ABC transporter permease - - - ko:K11689 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctQ k59_297794_1 1234664.AMRO01000004_gene2563 3.96e-262 729.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,1WFRN@129337|Geobacillus 91061|Bacilli P ATPases associated with a variety of cellular activities araG - 3.6.3.17 ko:K10548 ko02010,map02010 M00216 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.5 - - ABC_tran k59_297794_2 420246.GTNG_1801 8.89e-177 501.0 COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,4HDEY@91061|Bacilli,1WF6B@129337|Geobacillus 91061|Bacilli G Periplasmic binding protein domain chvE - - ko:K10546 ko02010,map02010 M00216 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.5 - - Peripla_BP_4 k59_297794_3 1105031.HMPREF1141_2716 6.84e-32 133.0 COG0363@1|root,COG1609@1|root,COG0363@2|Bacteria,COG1609@2|Bacteria,1V1UT@1239|Firmicutes,24E20@186801|Clostridia,36JF8@31979|Clostridiaceae 186801|Clostridia G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase - - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso,LacI,Peripla_BP_3 k59_891720_1 1454004.AW11_03619 4.02e-41 145.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,2W9IP@28216|Betaproteobacteria,1KR4K@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P CorA-like Mg2+ transporter protein - - - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_663911_2 1168034.FH5T_22035 3.73e-74 227.0 2APQJ@1|root,31EUD@2|Bacteria,4NNU5@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_141208_2 765910.MARPU_14405 1.53e-42 149.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1WVXU@135613|Chromatiales 135613|Chromatiales H Belongs to the NadC ModD family - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_40883_1 1128398.Curi_c25130 9.44e-17 80.5 COG5036@1|root,COG5036@2|Bacteria,1TYFN@1239|Firmicutes,24AGZ@186801|Clostridia,26BFG@186813|unclassified Clostridiales 186801|Clostridia P VTC domain - - - - - - - - - - - - VTC k59_40883_2 1121447.JONL01000009_gene2635 1.33e-40 145.0 COG1285@1|root,COG1285@2|Bacteria,1R2IF@1224|Proteobacteria,43DF6@68525|delta/epsilon subdivisions,2X8M5@28221|Deltaproteobacteria,2MDYG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 k59_826615_1 1517416.IDAT_04000 2.02e-151 439.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria,2QFRZ@267893|Idiomarinaceae 1236|Gammaproteobacteria M Peptidase dimerisation domain amaA - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_337351_1 870187.Thini_4486 5.12e-255 723.0 COG0210@1|root,COG0210@2|Bacteria,1MXV9@1224|Proteobacteria,1S9EG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,UvrD-helicase,UvrD_C k59_337351_2 402612.FP1562 2.71e-237 682.0 COG3593@1|root,COG3593@2|Bacteria,4NGAJ@976|Bacteroidetes,1HZZF@117743|Flavobacteriia,2NUSD@237|Flavobacterium 976|Bacteroidetes L AAA ATPase domain - - - - - - - - - - - - AAA_15 k59_630762_1 1105367.CG50_03855 1.29e-42 155.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2 k59_630762_2 1417296.U879_18285 9.12e-15 71.6 COG0745@1|root,COG0745@2|Bacteria,1MWVI@1224|Proteobacteria,2TRSP@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain ctrA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K02483,ko:K13584 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_990415_1 472759.Nhal_2578 9.41e-53 188.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_108193_2 1487953.JMKF01000050_gene1923 1.05e-81 248.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_533280_1 1122931.AUAE01000019_gene927 3.21e-135 397.0 COG3104@1|root,COG3104@2|Bacteria,4NIIT@976|Bacteroidetes,2FMR3@200643|Bacteroidia,22X2C@171551|Porphyromonadaceae 976|Bacteroidetes E POT family dtpD - - - - - - - - - - - MFS_1,PTR2 k59_270105_1 768671.ThimaDRAFT_4355 3.96e-52 183.0 COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,1SKFJ@1236|Gammaproteobacteria,1X099@135613|Chromatiales 135613|Chromatiales L COG0841 Cation multidrug efflux pump - - - - - - - - - - - - DDE_Tnp_1 k59_108194_1 1121405.dsmv_0063 3.03e-111 341.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MITU@213118|Desulfobacterales 28221|Deltaproteobacteria C CoA binding domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_956982_1 1089551.KE386572_gene4536 4.7e-09 59.7 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2TT78@28211|Alphaproteobacteria,4BQ9K@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Dimerisation domain of Zinc Transporter fieF - - ko:K13283 - - - - ko00000,ko02000 2.A.4.7.1 - - Cation_efflux,ZT_dimer k59_956982_2 1479237.JMLY01000001_gene531 4.13e-17 79.7 2CH0A@1|root,2ZANK@2|Bacteria,1R6U4@1224|Proteobacteria,1RQ3J@1236|Gammaproteobacteria,466JM@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_500520_1 545695.TREAZ_3430 2.78e-32 130.0 COG0534@1|root,COG0534@2|Bacteria,2J674@203691|Spirochaetes 203691|Spirochaetes V Mate efflux family protein - - - - - - - - - - - - MatE k59_858818_1 1009370.ALO_04928 5.78e-50 179.0 COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4H356@909932|Negativicutes 909932|Negativicutes GK PFAM ROK family protein - - - - - - - - - - - - HTH_24,MarR_2,ROK k59_925423_3 1118235.CAJH01000005_gene416 3.18e-06 49.3 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1X3SE@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the inositol monophosphatase superfamily suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_337372_1 1172190.M947_03890 3.76e-34 130.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42Q9B@68525|delta/epsilon subdivisions,2YNKN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2 k59_141229_4 555778.Hneap_1943 1.21e-210 586.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1WXY5@135613|Chromatiales 135613|Chromatiales L COG3039 Transposase and inactivated derivatives, IS5 family - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_598122_2 1002340.AFCF01000062_gene785 1.89e-12 71.2 COG2885@1|root,COG2885@2|Bacteria,1RAXN@1224|Proteobacteria,2U627@28211|Alphaproteobacteria,34FDH@302485|Phaeobacter 28211|Alphaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_891757_1 326298.Suden_0038 2.59e-68 214.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42R1M@68525|delta/epsilon subdivisions,2YNZ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, iron-sulfur protein - - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_337377_1 1151122.AQYD01000007_gene314 2.43e-39 144.0 COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4FN1X@85023|Microbacteriaceae 201174|Actinobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase garR - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_695788_1 1304865.JAGF01000001_gene3857 6.86e-161 481.0 COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4F11C@85016|Cellulomonadaceae 201174|Actinobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_6182_1 314278.NB231_08650 6.29e-127 398.0 COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1SYTD@1236|Gammaproteobacteria,1X2IM@135613|Chromatiales 135613|Chromatiales EO Peptidase family M28 - - - - - - - - - - - - PDZ_2,Peptidase_M1,Peptidase_M28 k59_75362_1 387092.NIS_1237 9.86e-113 333.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,42MJ1@68525|delta/epsilon subdivisions,2YMZ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0212 M20_dimer,Peptidase_M20 k59_433645_1 59196.RICGR_1132 4.36e-103 306.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1JCUB@118969|Legionellales 118969|Legionellales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_238303_1 1120999.JONM01000006_gene2458 1.69e-34 130.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,2KPIX@206351|Neisseriales 206351|Neisseriales S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF1732,YicC_N k59_141239_1 563040.Saut_1092 3.18e-28 105.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,42RRU@68525|delta/epsilon subdivisions,2YP7A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E acetolactate synthase ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_141239_2 326298.Suden_1138 1.49e-93 287.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2YMCF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_695792_1 247634.GPB2148_1890 3.7e-74 239.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1233 Phytoene dehydrogenase and related proteins - - - - - - - - - - - - Amino_oxidase k59_500553_1 2340.JV46_03710 2.12e-56 193.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_925447_1 944546.ABED_1045 6.03e-29 117.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,43BRF@68525|delta/epsilon subdivisions,2YNGV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H TonB dependent receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_826668_2 1123053.AUDG01000031_gene952 5.05e-07 55.8 COG1262@1|root,COG1520@1|root,COG2931@1|root,COG3209@1|root,COG1262@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,1QX0G@1224|Proteobacteria,1T32B@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - - k59_401468_1 1415779.JOMH01000001_gene3148 2.23e-32 127.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1X3KG@135614|Xanthomonadales 135614|Xanthomonadales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_433674_1 1238182.C882_4196 6.6e-16 80.5 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,2TR5T@28211|Alphaproteobacteria,2JRG5@204441|Rhodospirillales 204441|Rhodospirillales P Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_205965_1 1034347.CAHJ01000013_gene2443 1.36e-79 246.0 COG0310@1|root,COG0310@2|Bacteria,1TQVK@1239|Firmicutes,4HBKM@91061|Bacilli,1ZDXY@1386|Bacillus 91061|Bacilli P Cobalt uptake substrate-specific transmembrane region cbiM - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_205965_2 562970.Btus_0237 2.07e-24 95.5 COG1930@1|root,COG1930@2|Bacteria,1VF03@1239|Firmicutes,4HNIU@91061|Bacilli 91061|Bacilli P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import cbiN - - ko:K02009 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18 - - CbiN k59_205965_4 2325.TKV_c03410 3.86e-72 229.0 COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,42FBQ@68295|Thermoanaerobacterales 186801|Clostridia P part of an ABC transporter complex. Responsible for energy coupling to the transport system cbiO - - ko:K02006 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - ABC_tran k59_728110_1 1265503.KB905166_gene652 1.03e-08 61.6 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_858867_1 572480.Arnit_0244 9.1e-72 228.0 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,42MJ6@68525|delta/epsilon subdivisions,2YMEK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) ispDF - 2.7.7.60,4.6.1.12 ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_598164_1 1278306.KB906925_gene1707 4.05e-71 216.0 COG0102@1|root,COG0102@2|Bacteria,379Z6@32066|Fusobacteria 32066|Fusobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_598164_2 572544.Ilyop_1434 9.56e-77 230.0 COG0103@1|root,COG0103@2|Bacteria,37A4X@32066|Fusobacteria 32066|Fusobacteria J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_533350_1 56110.Oscil6304_2815 5.52e-18 89.0 COG1404@1|root,COG1520@1|root,COG2931@1|root,COG4733@1|root,COG4935@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,COG4733@2|Bacteria,COG4935@2|Bacteria,1G342@1117|Cyanobacteria,1HH6R@1150|Oscillatoriales 1117|Cyanobacteria O Beta-propeller repeat - - - - - - - - - - - - Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP k59_40951_1 292415.Tbd_2187 1.22e-82 254.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,2VI70@28216|Betaproteobacteria 28216|Betaproteobacteria S Radical_SAM C-terminal domain yhcC - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_565706_1 1123400.KB904752_gene839 1.73e-31 122.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4601N@72273|Thiotrichales 72273|Thiotrichales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_728629_2 572544.Ilyop_1857 1.9e-175 498.0 COG0472@1|root,COG0472@2|Bacteria,378U2@32066|Fusobacteria 32066|Fusobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_728629_3 526218.Sterm_0156 1.3e-75 243.0 COG0770@1|root,COG0770@2|Bacteria,378TN@32066|Fusobacteria 32066|Fusobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Hydrolase_like,Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_303350_1 1118235.CAJH01000014_gene875 4.97e-91 280.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1X2YM@135614|Xanthomonadales 135614|Xanthomonadales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_534009_1 765912.Thimo_2040 3.36e-108 330.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_991147_1 521719.ATXQ01000003_gene2006 1.38e-32 129.0 COG2268@1|root,COG2268@2|Bacteria,1P50K@1224|Proteobacteria,1RRHJ@1236|Gammaproteobacteria,1YFS7@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S protein conserved in bacteria yqiK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot k59_761195_1 1168034.FH5T_05690 6.74e-69 236.0 COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,2FMIV@200643|Bacteroidia 976|Bacteroidetes S Peptidase family C25 porU - - - - - - - - - - - Peptidase_C25 k59_859432_1 525898.Sdel_1461 6e-69 218.0 COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,42R60@68525|delta/epsilon subdivisions,2YNZM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulatory protein, C terminal - - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_859432_2 1121333.JMLH01000088_gene1610 1.9e-08 60.1 COG0642@1|root,COG2205@2|Bacteria,1TRD2@1239|Firmicutes,3VQ32@526524|Erysipelotrichia 526524|Erysipelotrichia T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_892478_2 398527.Bphyt_4755 1.07e-13 79.0 COG0039@1|root,COG0039@2|Bacteria,1PKKI@1224|Proteobacteria,2W8VX@28216|Betaproteobacteria,1K4U5@119060|Burkholderiaceae 28216|Betaproteobacteria C L-malate dehydrogenase activity - - - - - - - - - - - - - k59_6452_1 2340.JV46_05410 3.49e-264 736.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1J4ST@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0306 Phosphate sulphate permeases pitA - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_6452_2 269799.Gmet_2678 7.35e-09 59.3 COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,43UR0@69541|Desulfuromonadales 28221|Deltaproteobacteria T Universal stress protein usp-2 - - ko:K06149 - - - - ko00000 - - - Usp k59_6452_3 765910.MARPU_06320 1.65e-262 728.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1WWRM@135613|Chromatiales 135613|Chromatiales G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM k59_6452_4 765913.ThidrDRAFT_1376 3.94e-79 240.0 COG3090@1|root,COG3090@2|Bacteria,1R3YK@1224|Proteobacteria,1RZ8E@1236|Gammaproteobacteria,1WY1H@135613|Chromatiales 135613|Chromatiales G PFAM Tripartite ATP-independent periplasmic - - - ko:K11689 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctQ k59_6452_5 1121918.ARWE01000001_gene931 4.31e-170 482.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,42M9R@68525|delta/epsilon subdivisions,2WM0Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria G TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_6452_6 765912.Thimo_2114 2.47e-55 177.0 2FA41@1|root,342CW@2|Bacteria,1NZ2S@1224|Proteobacteria,1SQJN@1236|Gammaproteobacteria,1X0YZ@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF1842) - - - - - - - - - - - - - k59_6452_7 2340.JV46_04810 1.25e-131 390.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1J5K7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion macA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_6452_8 357804.Ping_3710 1.74e-85 259.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,2QJ1Q@267894|Psychromonadaceae 1236|Gammaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_6452_9 765912.Thimo_1431 4.42e-153 444.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXP0@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_6452_10 765912.Thimo_1430 7.09e-152 442.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXK2@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_6452_13 1049564.TevJSym_bs00060 0.0 1042.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1J517@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_6452_14 1049564.TevJSym_bs00050 3.67e-216 604.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1J99F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_6452_15 1049564.TevJSym_bs00040 1.81e-36 132.0 COG4970@1|root,COG4970@2|Bacteria,1QFYA@1224|Proteobacteria,1SDXQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU COG4970 Tfp pilus assembly protein FimT fimT - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_761204_1 754476.Q7A_2836 1.22e-83 258.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,4602K@72273|Thiotrichales 72273|Thiotrichales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_367889_1 1121918.ARWE01000001_gene692 3.13e-110 322.0 COG2771@1|root,COG2771@2|Bacteria,1R0W4@1224|Proteobacteria,43D2B@68525|delta/epsilon subdivisions 1224|Proteobacteria K the current gene model (or a revised gene model) may contain one or more premature stops and or frameshifts - - - - - - - - - - - - - k59_923765_1 395965.Msil_1828 1.69e-47 166.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,3N9SW@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Luciferase-like monooxygenase MA20_03405 - - - - - - - - - - - Bac_luciferase k59_268633_1 1168034.FH5T_06625 3.66e-56 199.0 COG2197@1|root,COG2197@2|Bacteria,4PKSX@976|Bacteroidetes,2FMGR@200643|Bacteroidia 976|Bacteroidetes KT COG NOG11230 non supervised orthologous group - - - - - - - - - - - - GerE,Y_Y_Y k59_791240_1 1163671.JAGI01000002_gene2940 7.08e-08 49.7 2BEYZ@1|root,328QN@2|Bacteria,1UUNU@1239|Firmicutes,2579Y@186801|Clostridia,36TX1@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_759688_53 572477.Alvin_2976 3.21e-135 387.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1WWSM@135613|Chromatiales 135613|Chromatiales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_759688_55 765911.Thivi_1735 2.05e-230 645.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1WWCI@135613|Chromatiales 135613|Chromatiales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_759688_56 1049564.TevJSym_at00440 2.22e-100 294.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1J8N8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_759688_57 935567.JAES01000002_gene677 1.24e-13 72.4 COG3153@1|root,COG3153@2|Bacteria,1RA42@1224|Proteobacteria,1S2G0@1236|Gammaproteobacteria,1X6YM@135614|Xanthomonadales 135614|Xanthomonadales S acetyltransferase - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_9 k59_759688_58 1144325.PMI22_04169 1.01e-155 451.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_596990_1 1168034.FH5T_12445 1.07e-88 266.0 COG2133@1|root,COG2133@2|Bacteria,4PKJE@976|Bacteroidetes,2G157@200643|Bacteroidia 976|Bacteroidetes G Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 k59_204863_1 387093.SUN_0974 5.36e-178 511.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42NGE@68525|delta/epsilon subdivisions,2YN37@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0471 Di- and tricarboxylate - - - ko:K03319 - - - - ko00000 2.A.47 - - Na_sulph_symp k59_368523_1 530564.Psta_1836 2.43e-78 253.0 COG3519@1|root,COG3519@2|Bacteria,2IYES@203682|Planctomycetes 203682|Planctomycetes S TIGRFAM type VI secretion protein, VC_A0110 family - - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF k59_237361_1 457405.FSDG_00120 2.59e-61 211.0 COG4928@1|root,COG4928@2|Bacteria,37C5I@32066|Fusobacteria 32066|Fusobacteria S KAP family P-loop domain - - - - - - - - - - - - KAP_NTPase k59_301993_1 95619.PM1_0221865 5e-79 248.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ATPase related to the helicase subunit of the Holliday junction resolvase rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_890648_1 658187.LDG_9029 5.72e-77 247.0 COG3724@1|root,COG3724@2|Bacteria,1MUJV@1224|Proteobacteria,1RNSS@1236|Gammaproteobacteria,1JCKY@118969|Legionellales 118969|Legionellales E Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) astB - 3.5.3.23 ko:K01484 ko00330,ko01100,map00330,map01100 - R04189 RC00024 ko00000,ko00001,ko01000 - - - AstB k59_924396_1 572544.Ilyop_1283 1.1e-102 299.0 COG0558@1|root,COG0558@2|Bacteria,3793M@32066|Fusobacteria 32066|Fusobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_466578_1 1116472.MGMO_8c00440 3.74e-27 113.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1XDXT@135618|Methylococcales 135618|Methylococcales P PFAM Binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_596998_1 1123368.AUIS01000003_gene1813 5.09e-82 258.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,2NDPB@225057|Acidithiobacillales 225057|Acidithiobacillales HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - RLAN k59_989348_1 387092.NIS_1815 3.22e-17 78.6 COG3381@1|root,COG3381@2|Bacteria,1R97V@1224|Proteobacteria,4306E@68525|delta/epsilon subdivisions,2YRX0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_825709_1 927658.AJUM01000037_gene1914 1.43e-71 217.0 COG2131@1|root,COG2131@2|Bacteria,4NM48@976|Bacteroidetes,2FRZ1@200643|Bacteroidia,3XJZZ@558415|Marinilabiliaceae 976|Bacteroidetes F MafB19-like deaminase comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_955896_1 1165841.SULAR_07755 3.73e-121 351.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2YMIH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_955896_2 1165841.SULAR_07760 5.58e-09 56.6 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2YN3F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_694848_2 215803.DB30_1737 7.03e-09 67.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1QABW@1224|Proteobacteria,43DZH@68525|delta/epsilon subdivisions,2WZ9U@28221|Deltaproteobacteria,2Z1NM@29|Myxococcales 28221|Deltaproteobacteria O Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - - k59_694848_3 582744.Msip34_2622 2.62e-46 159.0 2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,2VV7N@28216|Betaproteobacteria,2KMP7@206350|Nitrosomonadales 206350|Nitrosomonadales S Thermostable hemolysin - - - - - - - - - - - - T_hemolysin k59_694848_4 1123393.KB891316_gene1286 1.92e-145 433.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VN53@28216|Betaproteobacteria,1KS8D@119069|Hydrogenophilales 119069|Hydrogenophilales I AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_694848_5 314345.SPV1_01767 5.13e-98 291.0 COG5424@1|root,COG5424@2|Bacteria,1QVK0@1224|Proteobacteria 1224|Proteobacteria H Iron-containing redox enzyme - - - - - - - - - - - - Haem_oxygenas_2 k59_694848_7 301.JNHE01000002_gene2327 4.05e-61 201.0 COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,1S2HE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_694848_8 1123487.KB892863_gene1917 9.13e-55 181.0 COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,2VQ2E@28216|Betaproteobacteria,2KWK0@206389|Rhodocyclales 206389|Rhodocyclales NU COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_694848_9 395493.BegalDRAFT_0521 2.11e-84 256.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,460MZ@72273|Thiotrichales 72273|Thiotrichales T PFAM Response regulator receiver domain - - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_694848_10 983917.RGE_09270 6.19e-74 249.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VJBG@28216|Betaproteobacteria,1KPDV@119065|unclassified Burkholderiales 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain qseC - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_694848_11 2340.JV46_17810 5.19e-178 556.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9 k59_694848_12 1122604.JONR01000033_gene31 1.73e-131 382.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1X42V@135614|Xanthomonadales 135614|Xanthomonadales H polyphosphate kinase - - - - - - - - - - - - PPK2 k59_694848_14 944547.ABLL_2318 6.53e-08 63.2 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BUW@68525|delta/epsilon subdivisions,2YRCI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GGDEF k59_694848_16 1123253.AUBD01000014_gene868 7.71e-82 254.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria,1X2Z9@135614|Xanthomonadales 135614|Xanthomonadales S Nucleoside triphosphate mazG - 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - - MazG k59_694848_17 1049564.TevJSym_be00260 1.37e-100 303.0 COG1443@1|root,COG1443@2|Bacteria,1QXSY@1224|Proteobacteria,1RPX8@1236|Gammaproteobacteria 1236|Gammaproteobacteria I pfam nudix - - - - - - - - - - - - DUF4743,NUDIX k59_694848_18 1049564.TevJSym_be00270 4.73e-258 736.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J57P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_694848_19 1049564.TevJSym_be00280 1.34e-212 606.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1J55B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA GO:0003674,GO:0003824,GO:0004357,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042221,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046685,GO:0046689,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0070887,GO:0071241,GO:0071243,GO:0071248,GO:0071288,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_2885 Glu_cys_ligase k59_694848_20 243233.MCA2186 9.14e-123 359.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1XDTD@135618|Methylococcales 135618|Methylococcales IQ short-chain dehydrogenase reductase - - - - - - - - - - - - adh_short k59_694848_21 1049564.TevJSym_av00100 7.59e-138 394.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,1RNRP@1236|Gammaproteobacteria,1J4J0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N COG1291 Flagellar motor component pomA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009288,GO:0009425,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0071944,GO:0120100,GO:0120101 - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_694848_22 1049564.TevJSym_av00090 7.82e-55 191.0 COG1360@1|root,COG1360@2|Bacteria,1QUFR@1224|Proteobacteria,1T1XE@1236|Gammaproteobacteria,1J4JC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_694848_23 1049564.TevJSym_av00080 6.84e-53 174.0 2DTN4@1|root,32UVJ@2|Bacteria,1N2A5@1224|Proteobacteria,1SX01@1236|Gammaproteobacteria,1JB3B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_694848_24 1437882.AZRU01000010_gene542 3.1e-31 112.0 COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_694848_25 1049564.TevJSym_av00050 4.54e-97 288.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_694848_26 1049564.TevJSym_av00040 0.0 972.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1J5H2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon k59_694848_27 1049564.TevJSym_ax00230 7.81e-256 711.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1J555@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_694848_28 1049564.TevJSym_ax00210 3.98e-88 263.0 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1JBWT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E ACT domain gcvR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT,ACT_6 k59_694848_29 396588.Tgr7_0827 2.57e-137 396.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1WWMV@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_694848_30 1049564.TevJSym_ax00180 1.27e-118 354.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,1RZVF@1236|Gammaproteobacteria,1JBWE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M NlpB/DapX lipoprotein bamC - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_694848_31 323848.Nmul_A1139 2.7e-87 266.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria,372ZG@32003|Nitrosomonadales 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_694848_32 1049564.TevJSym_ab01650 0.0 1994.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1J54G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_694848_33 1121935.AQXX01000134_gene3588 8.68e-37 130.0 COG0589@1|root,COG0589@2|Bacteria,1RHE6@1224|Proteobacteria,1S6AR@1236|Gammaproteobacteria,1XK8T@135619|Oceanospirillales 135619|Oceanospirillales T Universal stress protein uspA - - ko:K06149 - - - - ko00000 - - - Usp k59_694848_34 675817.VDA_002335 5.42e-100 295.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1XT06@135623|Vibrionales 135623|Vibrionales H Riboflavin synthase alpha chain ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_694848_35 1049564.TevJSym_ac01720 3.72e-148 423.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1J5I0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004486,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0055114,GO:0071704,GO:1901360,GO:1901564 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_400446_1 1537917.JU82_08590 1.55e-59 196.0 COG5002@1|root,COG5002@2|Bacteria,1QZ29@1224|Proteobacteria,43CEG@68525|delta/epsilon subdivisions,2YTC2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_74364_1 247639.MGP2080_07012 8.44e-54 186.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - - - - - - - - - - PLDc_2 k59_727327_1 403833.Pmob_0064 4.61e-32 117.0 COG1347@1|root,COG1347@2|Bacteria,2GCJ2@200918|Thermotogae 200918|Thermotogae C Belongs to the NqrDE RnfAE family - - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_727327_2 1317118.ATO8_05016 1.86e-07 55.5 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,2U1PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_989353_1 686340.Metal_0770 1.49e-23 91.7 COG2921@1|root,COG2921@2|Bacteria,1PJDX@1224|Proteobacteria,1THTC@1236|Gammaproteobacteria,1XFN8@135618|Methylococcales 135618|Methylococcales S Belongs to the UPF0250 family - - - ko:K09158 - - - - ko00000 - - - DUF493 k59_989353_2 595494.Tola_2835 8.33e-63 199.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1Y473@135624|Aeromonadales 135624|Aeromonadales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_564672_1 1168034.FH5T_00820 5.58e-99 295.0 COG4677@1|root,COG4677@2|Bacteria,4NEEI@976|Bacteroidetes,2FMFM@200643|Bacteroidia 976|Bacteroidetes G Pectinesterase rhgT_2 - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Lipase_GDSL_2,Pectinesterase k59_499500_1 585425.KR52_06415 1.04e-17 77.8 COG3411@1|root,COG3411@2|Bacteria,1G5V6@1117|Cyanobacteria,1H0SH@1129|Synechococcus 1117|Cyanobacteria C ferredoxin like protein - - - - - - - - - - - - - k59_499500_2 999541.bgla_1g31070 9.19e-55 173.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1K7M9@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the P(II) protein family glnB - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_532272_1 762982.HMPREF9442_00147 1.64e-51 173.0 COG2227@1|root,COG2227@2|Bacteria,4PKW0@976|Bacteroidetes,2FNGZ@200643|Bacteroidia 976|Bacteroidetes H Methyltransferase domain protein cypM_1 - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_432836_1 880072.Desac_1676 3.92e-42 154.0 COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria,2MR85@213462|Syntrophobacterales 28221|Deltaproteobacteria H Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_368556_1 572477.Alvin_2698 4.97e-59 201.0 28JIE@1|root,2Z9BR@2|Bacteria,1R952@1224|Proteobacteria,1RRHU@1236|Gammaproteobacteria,1WVXG@135613|Chromatiales 135613|Chromatiales S Oxygen tolerance - - - - - - - - - - - - BatD k59_597022_1 1168034.FH5T_01615 7.48e-216 610.0 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,2FR1C@200643|Bacteroidia 976|Bacteroidetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_825732_1 1122201.AUAZ01000006_gene3909 2.22e-85 269.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,464FU@72275|Alteromonadaceae 1236|Gammaproteobacteria H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA GO:0003674,GO:0003824,GO:0004357,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042221,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046685,GO:0046689,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0070887,GO:0071241,GO:0071243,GO:0071248,GO:0071288,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_2885 Glu_cys_ligase k59_499516_1 748247.AZKH_p0057 3.37e-26 103.0 COG0607@1|root,COG0607@2|Bacteria,1RHNV@1224|Proteobacteria,2VSK8@28216|Betaproteobacteria,2KWKY@206389|Rhodocyclales 206389|Rhodocyclales P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - k59_499516_2 155864.EDL933_3676 3.88e-07 51.6 COG1145@1|root,COG1145@2|Bacteria,1MWHY@1224|Proteobacteria,1RP5W@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_7 k59_237391_1 572544.Ilyop_1499 4.95e-112 332.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion hflC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_237391_2 572544.Ilyop_1500 5.39e-127 373.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_237391_3 572544.Ilyop_1501 8.09e-167 476.0 COG1623@1|root,COG1623@2|Bacteria,378ZQ@32066|Fusobacteria 32066|Fusobacteria H Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process disA - 2.7.7.85 ko:K07067 - - - - ko00000,ko01000 - - - DisA-linker,DisA_N k59_237391_4 469616.FMAG_00098 6.13e-211 596.0 COG1066@1|root,COG1066@2|Bacteria,378XW@32066|Fusobacteria 32066|Fusobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - ATPase,Lon_C k59_237391_5 572544.Ilyop_1503 2.88e-70 216.0 COG0669@1|root,COG0669@2|Bacteria,37AD2@32066|Fusobacteria 32066|Fusobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_237391_6 572544.Ilyop_1504 8.8e-99 302.0 COG1530@1|root,COG1530@2|Bacteria,378E6@32066|Fusobacteria 32066|Fusobacteria J Ribonuclease E/G family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G k59_432868_1 387093.SUN_1447 7.29e-124 363.0 COG1234@1|root,COG1234@2|Bacteria,1Q4PW@1224|Proteobacteria,42PQE@68525|delta/epsilon subdivisions,2YNTI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_791600_1 929558.SMGD1_1006 7.5e-179 511.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2YMF8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_302033_1 709032.Sulku_1206 1.4e-22 115.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind,Laminin_G_3 k59_989402_1 998674.ATTE01000001_gene612 3.91e-132 393.0 2C5WB@1|root,2Z7IZ@2|Bacteria,1RCRD@1224|Proteobacteria,1S332@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_107355_2 1408422.JHYF01000014_gene194 5.48e-65 202.0 COG2606@1|root,COG2606@2|Bacteria,1V6JF@1239|Firmicutes,24I4E@186801|Clostridia,36IS6@31979|Clostridiaceae 186801|Clostridia S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ybaK - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_107355_3 1122221.JHVI01000011_gene948 1.99e-26 100.0 COG1324@1|root,COG1324@2|Bacteria,1WKG6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P PFAM CutA1 divalent ion tolerance protein cutA - - ko:K03926 - - - - ko00000 - - - CutA1 k59_499554_1 765913.ThidrDRAFT_1468 1.17e-25 105.0 COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,1RQUQ@1236|Gammaproteobacteria,1WXKD@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0502 family - - - ko:K09915 - - - - ko00000 - - - DUF480 k59_564732_1 497964.CfE428DRAFT_5143 7.91e-77 249.0 COG1960@1|root,COG1960@2|Bacteria,46TJY@74201|Verrucomicrobia 74201|Verrucomicrobia I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_432876_1 1168034.FH5T_06970 3.76e-144 419.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,4NEZC@976|Bacteroidetes,2FSM8@200643|Bacteroidia 976|Bacteroidetes G Glucose / Sorbosone dehydrogenase - - - ko:K21430 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,GSDH k59_858016_1 991.IW20_04910 1.02e-51 177.0 COG0438@1|root,COG0438@2|Bacteria,4NIXA@976|Bacteroidetes,1HYIA@117743|Flavobacteriia,2NSE0@237|Flavobacterium 976|Bacteroidetes M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1021930_1 85643.Tmz1t_2950 7.9e-111 331.0 COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2W3EH@28216|Betaproteobacteria,2KZ1E@206389|Rhodocyclales 206389|Rhodocyclales E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_992571_1 944547.ABLL_2574 8.45e-35 129.0 COG2010@1|root,COG2010@2|Bacteria,1PDTK@1224|Proteobacteria,42N5Z@68525|delta/epsilon subdivisions,2YMTR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_992571_2 1172190.M947_05945 4.17e-20 82.4 2AIVC@1|root,32MS0@2|Bacteria,1Q3D2@1224|Proteobacteria,42X4G@68525|delta/epsilon subdivisions,2YQTS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Family of unknown function (DUF4006) - - - - - - - - - - - - DUF4006 k59_435607_1 439235.Dalk_5037 5.58e-37 132.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2WMUI@28221|Deltaproteobacteria,2MIBY@213118|Desulfobacterales 28221|Deltaproteobacteria L TIGRFAM hydrolase, TatD family tatD - - ko:K03424 - - - - ko00000,ko01000 - - - Fer4_14,Radical_SAM,TatD_DNase k59_535472_1 1168034.FH5T_13490 6.02e-98 302.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_403410_1 1123248.KB893334_gene2764 4.19e-08 63.5 COG4637@1|root,COG4637@2|Bacteria,4PNSQ@976|Bacteroidetes,1IUHX@117747|Sphingobacteriia 976|Bacteroidetes S AAA ATPase domain - - - - - - - - - - - - AAA_21 k59_403410_3 944481.JAFP01000001_gene1269 3.86e-09 57.4 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,2M76J@213113|Desulfurellales 28221|Deltaproteobacteria O CS domain hspA-1 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_927444_1 1121904.ARBP01000036_gene2102 1.84e-20 96.3 COG1404@1|root,COG1404@2|Bacteria,4NRWQ@976|Bacteroidetes 976|Bacteroidetes O Belongs to the peptidase S8 family - - - - - - - - - - - - - k59_175656_1 1249480.B649_11085 2.8e-132 408.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2YMVS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C k59_42676_2 4081.Solyc10g047440.1.1 6.67e-06 49.3 2CMQD@1|root,2QRDV@2759|Eukaryota,37QIN@33090|Viridiplantae,3GEA1@35493|Streptophyta 35493|Streptophyta S function. Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009509,GO:0009532,GO:0009536,GO:0009570,GO:0009575,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 - - - - - - - - - - AAA,DUF825 k59_77203_1 96561.Dole_0330 2.85e-24 105.0 COG3168@1|root,COG3168@2|Bacteria,1N39F@1224|Proteobacteria,42U30@68525|delta/epsilon subdivisions,2WRT8@28221|Deltaproteobacteria,2MPRF@213118|Desulfobacterales 28221|Deltaproteobacteria NU Pilus assembly protein, PilP - - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_77203_2 1125863.JAFN01000001_gene2285 6.45e-20 86.7 COG3167@1|root,COG3167@2|Bacteria,1MZZ4@1224|Proteobacteria,43B6P@68525|delta/epsilon subdivisions,2X6K9@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU PFAM Pilus assembly protein PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_1024369_1 1168034.FH5T_18480 5.02e-56 181.0 COG1528@1|root,COG1528@2|Bacteria,4NGS7@976|Bacteroidetes,2FQD1@200643|Bacteroidia 976|Bacteroidetes P Iron-storage protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin k59_1024369_2 469618.FVAG_02147 5.84e-98 288.0 COG1592@1|root,COG1592@2|Bacteria,378PE@32066|Fusobacteria 32066|Fusobacteria C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_1024369_3 1341157.RF007C_05360 9.9e-16 70.5 COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,3WKG3@541000|Ruminococcaceae 186801|Clostridia C PFAM Rubredoxin-type Fe(Cys)4 protein rub - 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Rubredoxin k59_1024369_4 1209989.TepiRe1_0396 3.25e-28 101.0 COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,42H59@68295|Thermoanaerobacterales 186801|Clostridia C PFAM Rubredoxin-type Fe(Cys)4 protein rd GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0017144,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114,GO:0072592 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Rubredoxin k59_697872_1 1499968.TCA2_2870 2.62e-181 523.0 COG1621@1|root,COG1621@2|Bacteria,1TPAE@1239|Firmicutes,4H9Y7@91061|Bacilli,26QVU@186822|Paenibacillaceae 91061|Bacilli G invertase scrB - 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 - GH32 - Glyco_hydro_32C,Glyco_hydro_32N k59_697872_2 1304284.L21TH_0828 2.35e-62 201.0 COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia,36DU6@31979|Clostridiaceae 186801|Clostridia G PfkB family - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_109992_1 1150621.SMUL_1638 3.98e-18 83.2 COG3658@1|root,COG3658@2|Bacteria,1REFV@1224|Proteobacteria,42Q0G@68525|delta/epsilon subdivisions,2YN98@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome - - - - - - - - - - - - DHC,Ni_hydr_CYTB k59_109992_2 1565314.OA34_04985 0.0 1102.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2YN9X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_77209_1 99598.Cal7507_3941 0.000264 47.4 2APM1@1|root,31EQC@2|Bacteria,1G6ZJ@1117|Cyanobacteria,1HMHI@1161|Nostocales 1117|Cyanobacteria S 2TM domain - - - - - - - - - - - - 2TM k59_371442_1 1168034.FH5T_16600 1.25e-147 426.0 COG4656@1|root,COG4656@2|Bacteria,4NIS7@976|Bacteroidetes,2FMAQ@200643|Bacteroidia 976|Bacteroidetes C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,Fer4_7,RnfC_N,SLBB k59_304674_1 1042375.AFPL01000038_gene1543 4.85e-14 75.5 COG2207@1|root,COG2207@2|Bacteria,1RG3C@1224|Proteobacteria,1S50G@1236|Gammaproteobacteria,46B4R@72275|Alteromonadaceae 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_893994_2 1318628.MARLIPOL_09391 5.06e-38 135.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,467AQ@72275|Alteromonadaceae 1236|Gammaproteobacteria L Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_535493_2 948106.AWZT01000032_gene1897 3.53e-59 192.0 COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VI3W@28216|Betaproteobacteria,1K1QP@119060|Burkholderiaceae 28216|Betaproteobacteria E abc transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_567707_1 1121859.KB890754_gene1085 3.09e-22 95.9 COG2070@1|root,COG2070@2|Bacteria,4NEGW@976|Bacteroidetes,47JXU@768503|Cytophagia 976|Bacteroidetes S 2-Nitropropane dioxygenase - - - - - - - - - - - - - k59_600399_1 1408439.JHXW01000007_gene8 6.55e-72 229.0 COG1775@1|root,COG1775@2|Bacteria,378XN@32066|Fusobacteria 32066|Fusobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component hgdB - 4.2.1.167 ko:K20904 - - - - ko00000,ko01000 - - - HGD-D k59_109999_1 1304275.C41B8_14215 3.53e-39 150.0 COG3213@1|root,COG3213@2|Bacteria,1PJXJ@1224|Proteobacteria,1S4J4@1236|Gammaproteobacteria 1236|Gammaproteobacteria P protein involved in response to NO - - - ko:K07234 - - - - ko00000 - - - NnrS k59_1024390_1 1168034.FH5T_17425 2.59e-98 297.0 COG0148@1|root,COG0148@2|Bacteria,4NF5M@976|Bacteroidetes,2FMNI@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_600403_1 714943.Mucpa_0036 1.14e-72 244.0 COG3408@1|root,COG3408@2|Bacteria,4NE1I@976|Bacteroidetes,1IRGN@117747|Sphingobacteriia 976|Bacteroidetes G Domain of unknown function (DUF4450) - - - - - - - - - - - - Bac_rhamnosid6H,DUF4450,DUF608 k59_143414_1 404380.Gbem_1799 1.19e-17 88.6 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria 1224|Proteobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Big_3_2,Big_3_3,fn3 k59_959116_1 387093.SUN_1243 1.38e-98 302.0 COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria,43CEV@68525|delta/epsilon subdivisions,2YRH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_633022_1 1121396.KB893122_gene3040 5.27e-43 144.0 COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66 k59_403441_1 65393.PCC7424_3829 3.62e-55 187.0 COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,3KFX6@43988|Cyanothece 1117|Cyanobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_143416_1 1168034.FH5T_14590 1.16e-47 160.0 COG2755@1|root,COG2755@2|Bacteria,4NMUB@976|Bacteroidetes,2FQW2@200643|Bacteroidia 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 k59_143416_2 1307761.L21SP2_0990 7.68e-14 71.6 COG2271@1|root,COG2271@2|Bacteria 2|Bacteria G transmembrane transporter activity - - - - - - - - - - - - MFS_1 k59_894006_1 697282.Mettu_3706 6.22e-64 220.0 COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,1SMTI@1236|Gammaproteobacteria,1XF86@135618|Methylococcales 135618|Methylococcales Q PFAM Beta-ketoacyl synthase, N-terminal - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_304687_1 439235.Dalk_0058 6.05e-117 345.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42NHU@68525|delta/epsilon subdivisions,2WIZ1@28221|Deltaproteobacteria,2MIQ6@213118|Desulfobacterales 28221|Deltaproteobacteria I acyl-CoA dehydrogenase - - 1.3.99.32 ko:K16173 ko00362,ko01120,map00362,map01120 - R05579 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_666072_1 1121405.dsmv_1666 8.11e-144 436.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_271744_1 396588.Tgr7_2703 5.22e-168 476.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1X1FE@135613|Chromatiales 135613|Chromatiales L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_4 k59_271744_4 522306.CAP2UW1_3983 8.1e-174 496.0 COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,2VMFB@28216|Betaproteobacteria 28216|Betaproteobacteria M FtsX-like permease family - - - - - - - - - - - - FtsX k59_271744_5 85643.Tmz1t_0681 9.3e-92 276.0 COG1136@1|root,COG1136@2|Bacteria,1PFRW@1224|Proteobacteria,2VIPF@28216|Betaproteobacteria,2KVPU@206389|Rhodocyclales 206389|Rhodocyclales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_271744_6 522306.CAP2UW1_3981 1.08e-108 327.0 28K4S@1|root,2Z9TM@2|Bacteria,1N4AQ@1224|Proteobacteria,2VK2F@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_271744_7 589865.DaAHT2_2665 1.15e-71 224.0 COG4314@1|root,COG4314@2|Bacteria,1RID8@1224|Proteobacteria,42SYX@68525|delta/epsilon subdivisions,2WPEE@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NosL - - - - - - - - - - - - NosL k59_271744_8 1121035.AUCH01000012_gene2923 3.22e-65 204.0 COG4314@1|root,COG4314@2|Bacteria,1N43A@1224|Proteobacteria,2VQI4@28216|Betaproteobacteria,2KWIY@206389|Rhodocyclales 206389|Rhodocyclales C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - NosL k59_271744_9 237368.SCABRO_01662 3.64e-289 806.0 COG1274@1|root,COG1274@2|Bacteria,2J235@203682|Planctomycetes 203682|Planctomycetes C Phosphoenolpyruvate carboxykinase C-terminal P-loop domain - - - - - - - - - - - - PEPCK_C,PEPCK_N k59_271744_10 1049564.TevJSym_ad01130 1.96e-75 229.0 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,1S9FV@1236|Gammaproteobacteria,1J73Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria ychJ - - ko:K09858 - - - - ko00000 - - - SEC-C k59_271744_11 631362.Thi970DRAFT_03539 2.07e-42 151.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,1WXMB@135613|Chromatiales 135613|Chromatiales M Soluble lytic murein transglycosylase-like protein - - - - - - - - - - - - DUF4124,SLT k59_271744_12 357804.Ping_1660 1.01e-48 162.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,2QI3R@267894|Psychromonadaceae 1236|Gammaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB GO:0003674,GO:0003824,GO:0006091,GO:0006457,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0022900,GO:0044237,GO:0050896,GO:0055114 - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - iAF1260.b1185,iB21_1397.B21_01170,iBWG_1329.BWG_1010,iEC042_1314.EC042_1234,iEC55989_1330.EC55989_1280,iECBD_1354.ECBD_2437,iECB_1328.ECB_01160,iECDH10B_1368.ECDH10B_1238,iECDH1ME8569_1439.ECDH1ME8569_1124,iECD_1391.ECD_01160,iECED1_1282.ECED1_1327,iECIAI1_1343.ECIAI1_1202,iECO103_1326.ECO103_1287,iECSP_1301.ECSP_1582,iECUMN_1333.ECUMN_1474,iECs_1301.ECs1680,iETEC_1333.ETEC_1289,iEcDH1_1363.EcDH1_2463,iEcHS_1320.EcHS_A1288,iEcSMS35_1347.EcSMS35_1964,iEcolC_1368.EcolC_2440,iG2583_1286.G2583_1446,iJO1366.b1185,iSDY_1059.SDY_1222,iY75_1357.Y75_RS06185 DsbB k59_271744_13 870187.Thini_3864 1.41e-69 213.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S8W1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_271744_14 105559.Nwat_1567 3.63e-53 174.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_271744_15 1042375.AFPL01000019_gene269 1.7e-143 414.0 COG4886@1|root,COG4886@2|Bacteria,1NBPC@1224|Proteobacteria,1SRN3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Leucine-rich repeat (LRR) protein - - - - - - - - - - - - - k59_271744_16 1109445.AGSX01000187_gene2397 3.76e-09 55.5 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1SCFA@1236|Gammaproteobacteria,1Z3G2@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O Belongs to the sulfur carrier protein TusA family - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_271744_17 1408433.JHXV01000008_gene224 1.02e-127 377.0 COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1I0RF@117743|Flavobacteriia 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_271744_18 1116472.MGMO_26c00100 6.64e-212 602.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,1XENF@135618|Methylococcales 135618|Methylococcales S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 k59_271744_20 871585.BDGL_000155 3.14e-29 111.0 COG2703@1|root,COG2703@2|Bacteria,1RI40@1224|Proteobacteria,1S705@1236|Gammaproteobacteria,3NKT1@468|Moraxellaceae 1236|Gammaproteobacteria P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_271744_21 1123368.AUIS01000032_gene1396 7.32e-159 460.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,2NBRQ@225057|Acidithiobacillales 1236|Gammaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans - - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_271744_22 713586.KB900536_gene823 2.36e-55 177.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,1WYJN@135613|Chromatiales 135613|Chromatiales J PFAM Class I peptide chain release factor - - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_271744_23 864051.BurJ1DRAFT_0827 1.06e-96 305.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,1KJ5A@119065|unclassified Burkholderiales 28216|Betaproteobacteria KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_271744_24 164328.Phyra79915 2.01e-90 277.0 COG0179@1|root,KOG1535@2759|Eukaryota,3Q7FG@4776|Peronosporales 4776|Peronosporales Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - FAA_hydrolase k59_271744_25 414684.RC1_1593 5.26e-250 698.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPSC@204441|Rhodospirillales 204441|Rhodospirillales C belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_271744_26 1123487.KB892866_gene1602 2.92e-197 620.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KUCK@206389|Rhodocyclales 206389|Rhodocyclales T Diguanylate cyclase - - - - - - - - - - - - CBS,CZB,EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_271744_27 697282.Mettu_1938 1.13e-32 120.0 COG2703@1|root,COG2703@2|Bacteria,1PGPP@1224|Proteobacteria,1RX1T@1236|Gammaproteobacteria,1XGPW@135618|Methylococcales 135618|Methylococcales P PFAM Haemerythrin HHE cation-binding motif - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_271744_28 713587.THITH_16865 2.05e-206 626.0 COG2203@1|root,COG2206@1|root,COG3221@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3221@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria,1X2BG@135613|Chromatiales 135613|Chromatiales T HD domain - - - - - - - - - - - - GAF_2,HD,PAS_4 k59_271744_29 1121035.AUCH01000025_gene3328 1.67e-186 524.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VI1Z@28216|Betaproteobacteria,2KVIB@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_271744_30 459495.SPLC1_S410770 1.07e-68 249.0 COG0642@1|root,COG0784@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H71C@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,Response_reg k59_271744_32 314345.SPV1_11096 5.41e-136 392.0 COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria 1224|Proteobacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_271744_33 335283.Neut_2531 7.93e-60 194.0 COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,3737H@32003|Nitrosomonadales 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF882) - - - - - - - - - - - - Peptidase_M15_2 k59_829251_3 572544.Ilyop_0770 0.0 962.0 COG0488@1|root,COG0488@2|Bacteria,379IT@32066|Fusobacteria 32066|Fusobacteria S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_928114_1 1313421.JHBV01000006_gene360 2.44e-56 197.0 COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1INN3@117747|Sphingobacteriia 2|Bacteria E PFAM Aminotransferase class I and II - - 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Acetyltransf_6,Aminotran_1_2 k59_633719_1 243233.MCA2174 1.32e-75 236.0 COG0803@1|root,COG0803@2|Bacteria,1RAQU@1224|Proteobacteria 1224|Proteobacteria P Zinc-uptake complex component A periplasmic - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_404082_1 314345.SPV1_06999 5.32e-77 244.0 COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria 1224|Proteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase2 k59_928115_1 1294143.H681_22215 5.49e-51 177.0 COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria 1236|Gammaproteobacteria T CBS-domain-containing membrane protein - - - ko:K07168 - - - - ko00000 - - - HPP k59_730318_1 709032.Sulku_1540 6e-33 123.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,42QJ2@68525|delta/epsilon subdivisions,2YNBV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG3864 conserved - - - - - - - - - - - - DUF2201,DUF2201_N k59_208874_1 572544.Ilyop_0169 0.0 1353.0 COG0495@1|root,COG0495@2|Bacteria,378GP@32066|Fusobacteria 32066|Fusobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1 k59_208874_2 572544.Ilyop_0168 8.23e-101 298.0 COG1595@1|root,COG1595@2|Bacteria,37937@32066|Fusobacteria 32066|Fusobacteria K Helix-turn-helix domain - - - ko:K03091 - - - - ko00000,ko03021 - - - GerE,Sigma70_r2 k59_208874_3 1319815.HMPREF0202_00976 4.86e-114 333.0 COG0566@1|root,COG0566@2|Bacteria,378DU@32066|Fusobacteria 32066|Fusobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_208874_4 1319815.HMPREF0202_00975 6.35e-216 607.0 COG0766@1|root,COG0766@2|Bacteria,37878@32066|Fusobacteria 32066|Fusobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_208874_5 1408439.JHXW01000013_gene1038 9.2e-45 153.0 COG5506@1|root,COG5506@2|Bacteria,37AKR@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF1694 k59_208874_6 246194.CHY_1258 1.35e-45 169.0 COG3395@1|root,COG3395@2|Bacteria,1TPNP@1239|Firmicutes,24AJF@186801|Clostridia,42G57@68295|Thermoanaerobacterales 186801|Clostridia S PFAM type III effector Hrp-dependent outers - - 2.7.1.219,2.7.1.220 ko:K22129 - - - - ko00000,ko01000 - - - DUF1357_C,DUF1537 k59_208874_7 439292.Bsel_3301 4.63e-16 82.4 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,26NHF@186821|Sporolactobacillaceae 91061|Bacilli T His Kinase A (phosphoacceptor) domain vicK - 2.7.13.3 ko:K07652 ko02020,map02020 M00459 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_9 k59_305407_1 765910.MARPU_15120 5.38e-91 280.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_666765_1 595460.RRSWK_01898 1.96e-05 54.3 COG0524@1|root,COG0524@2|Bacteria,2IYK0@203682|Planctomycetes 203682|Planctomycetes G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB k59_536051_1 1168034.FH5T_17355 3.65e-65 221.0 COG0457@1|root,COG0457@2|Bacteria,4NFFS@976|Bacteroidetes,2FMYG@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_12,TPR_16,TPR_19,TPR_6,TPR_7,TPR_8 k59_372026_1 323259.Mhun_0663 1.03e-12 70.5 COG0303@1|root,arCOG00216@2157|Archaea,2Y7MS@28890|Euryarchaeota,2NBMK@224756|Methanomicrobia 224756|Methanomicrobia H MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_181757_1 1545915.JROG01000004_gene2128 5.23e-98 301.0 COG2939@1|root,COG2939@2|Bacteria,1R9MX@1224|Proteobacteria,2U4C1@28211|Alphaproteobacteria,2K3TS@204457|Sphingomonadales 204457|Sphingomonadales E Serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_181758_1 929558.SMGD1_1845 1.61e-82 252.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2YMTK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_441360_1 1165841.SULAR_09579 3.44e-65 207.0 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,42MHJ@68525|delta/epsilon subdivisions,2YMM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S dinuclear metal center protein, YbgI - - 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - NIF3 k59_82491_1 561180.BIFGAL_02708 4.03e-61 207.0 COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4CYWI@85004|Bifidobacteriales 201174|Actinobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_277088_1 215803.DB30_1694 9.36e-64 208.0 COG2182@1|root,COG2182@2|Bacteria,1N9AE@1224|Proteobacteria,43EXV@68525|delta/epsilon subdivisions,2X9AJ@28221|Deltaproteobacteria,2YZDJ@29|Myxococcales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein - - - ko:K10108,ko:K15770 ko02010,ko02030,map02010,map02030 M00194,M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22 - - SBP_bac_1 k59_573235_1 269799.Gmet_3341 4.33e-97 293.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,43VCE@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM transposase mutator type - - - - - - - - - - - - Transposase_mut k59_899809_2 583345.Mmol_1597 5.58e-52 171.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,2KKQS@206350|Nitrosomonadales 206350|Nitrosomonadales C Belongs to the complex I subunit 6 family - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_181774_2 387093.SUN_1754 3.67e-116 338.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,42MMC@68525|delta/epsilon subdivisions,2YMS8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the TtcA family ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_376914_1 746697.Aeqsu_1446 3.87e-66 206.0 COG0848@1|root,COG0848@2|Bacteria,4NHYQ@976|Bacteroidetes,1HYCZ@117743|Flavobacteriia 976|Bacteroidetes U Pfam Biopolymer transport protein ExbD TolR - - - - - - - - - - - - ExbD k59_376914_2 1120951.AUBG01000010_gene1964 3.19e-27 105.0 2AT2U@1|root,31IIU@2|Bacteria,4NS9K@976|Bacteroidetes,1I3WD@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_768933_2 251221.35214500 7.38e-72 237.0 COG0480@1|root,COG0480@2|Bacteria,1G1KG@1117|Cyanobacteria 1117|Cyanobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_376916_1 228410.NE0768 2.86e-98 309.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,3725U@32003|Nitrosomonadales 28216|Betaproteobacteria O Cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_768936_1 1121289.JHVL01000035_gene2627 3.29e-33 125.0 COG0500@1|root,COG2226@2|Bacteria,1V6QV@1239|Firmicutes,24JPQ@186801|Clostridia,36IM9@31979|Clostridiaceae 186801|Clostridia Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_409184_1 641107.CDLVIII_4824 1.06e-82 267.0 COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,36F1Q@31979|Clostridiaceae 186801|Clostridia U Major facilitator superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_409184_2 944547.ABLL_2514 7.67e-75 231.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2YMZV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM SNARE associated Golgi protein dedA - - - - - - - - - - - SNARE_assoc k59_409184_3 293826.Amet_2967 3.97e-139 416.0 COG3290@1|root,COG3290@2|Bacteria,1TQJR@1239|Firmicutes,247YE@186801|Clostridia,36EQS@31979|Clostridiaceae 186801|Clostridia T signal transduction histidine kinase regulating citrate malate metabolism citS - 2.7.13.3 ko:K02476,ko:K11614,ko:K11691 ko02020,map02020 M00489,M00490 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HATPase_c_5,PAS,PAS_10,PAS_8,PAS_9,SPOB_a,sCache_3_2 k59_798146_1 1537917.JU82_00940 1.26e-88 283.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2YN2C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT,HD_4,RelA_SpoT,TGS k59_798146_2 709032.Sulku_1852 1.67e-211 592.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2YMD3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_573252_1 156889.Mmc1_0518 7.37e-75 239.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria 28211|Alphaproteobacteria S CBS domain containing protein - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_474373_2 1232437.KL661973_gene5028 5.69e-58 191.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2MHTU@213118|Desulfobacterales 28221|Deltaproteobacteria E Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_376918_1 1095747.HMPREF1049_0389 1.34e-111 327.0 COG1028@1|root,COG1028@2|Bacteria,378C6@32066|Fusobacteria 32066|Fusobacteria IQ K00059 3-oxoacyl- acyl-carrier protein reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_376918_2 546275.FUSPEROL_02419 4.49e-195 551.0 COG0183@1|root,COG0183@2|Bacteria,378R0@32066|Fusobacteria 32066|Fusobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_376918_4 1095747.HMPREF1049_1533 2.24e-49 159.0 COG2030@1|root,COG2030@2|Bacteria,37A21@32066|Fusobacteria 32066|Fusobacteria I N-terminal half of MaoC dehydratase - - 4.2.1.55 ko:K17865 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R03027 RC00831 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas k59_12044_1 1396141.BATP01000034_gene4155 7.88e-78 250.0 COG0539@1|root,COG0539@2|Bacteria,46SFY@74201|Verrucomicrobia,2ITUF@203494|Verrucomicrobiae 203494|Verrucomicrobiae J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_82950_2 697282.Mettu_1042 7.68e-18 85.5 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1XEGN@135618|Methylococcales 135618|Methylococcales L DHH family recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_441864_1 545243.BAEV01000057_gene178 6.44e-18 78.2 2DR4V@1|root,33A63@2|Bacteria,1VKGM@1239|Firmicutes 1239|Firmicutes S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF3343 k59_441864_2 572544.Ilyop_1137 1.27e-138 403.0 COG2603@1|root,COG2603@2|Bacteria,3792M@32066|Fusobacteria 32066|Fusobacteria S tRNA 2-selenouridine synthase selU - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_798857_1 1196322.A370_03792 2.2e-67 221.0 COG0498@1|root,COG0498@2|Bacteria,1TPR0@1239|Firmicutes,248YY@186801|Clostridia,36DKM@31979|Clostridiaceae 186801|Clostridia E Threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS16355 PALP,Thr_synth_N k59_474994_1 1168034.FH5T_17020 1.1e-116 346.0 COG0141@1|root,COG0141@2|Bacteria,4NFPZ@976|Bacteroidetes,2FMY9@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_900310_1 879212.DespoDRAFT_02176 1.36e-32 122.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,42UCU@68525|delta/epsilon subdivisions,2WR0U@28221|Deltaproteobacteria,2MKMP@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family - - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_998953_1 870187.Thini_3978 4.17e-68 213.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,460NW@72273|Thiotrichales 72273|Thiotrichales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_48610_1 1122603.ATVI01000009_gene2559 5.6e-55 191.0 COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,1RNRM@1236|Gammaproteobacteria,1XABF@135614|Xanthomonadales 135614|Xanthomonadales V ABC transporter transmembrane region - - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_441868_1 1168034.FH5T_09700 1.88e-21 87.4 COG0669@1|root,COG0669@2|Bacteria,4NM84@976|Bacteroidetes,2FT6A@200643|Bacteroidia 976|Bacteroidetes H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_441868_2 1408473.JHXO01000006_gene1209 3.53e-272 766.0 COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,2FWMX@200643|Bacteroidia 976|Bacteroidetes E Amino acid permease - - - - - - - - - - - - AA_permease k59_735818_2 1150621.SMUL_0632 6.69e-28 102.0 2BPAR@1|root,32I2N@2|Bacteria,1Q1NX@1224|Proteobacteria,4319B@68525|delta/epsilon subdivisions,2YS82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_735818_3 525898.Sdel_0473 7.41e-41 135.0 COG2026@1|root,COG2026@2|Bacteria,1QDRJ@1224|Proteobacteria,434AA@68525|delta/epsilon subdivisions,2YRZ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria DJ ParE toxin of type II toxin-antitoxin system, parDE - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin k59_409800_1 1415779.JOMH01000001_gene2492 2.42e-55 182.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S6JM@1236|Gammaproteobacteria,1X69J@135614|Xanthomonadales 135614|Xanthomonadales S of the alpha beta superfamily - - - ko:K06889 - - - - ko00000 - - - Abhydrolase_4,Hydrolase_4 k59_48618_1 1095769.CAHF01000014_gene3046 2.78e-30 119.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria,473EQ@75682|Oxalobacteraceae 28216|Betaproteobacteria D Peptidase family M23 envC - - - - - - - - - - - Peptidase_M23 k59_48618_2 1049564.TevJSym_at00280 1.3e-133 393.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J4IS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_998957_1 1249480.B649_03015 8.9e-177 501.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2YMIS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_998957_2 1249480.B649_03020 1.07e-57 183.0 2BM55@1|root,32FNN@2|Bacteria,1Q0P6@1224|Proteobacteria,42SB7@68525|delta/epsilon subdivisions,2YPGR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DNA replication regulator hobA - - - - - - - - - - - HobA k59_246439_1 1408473.JHXO01000008_gene2887 1.49e-19 94.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,4NDXU@976|Bacteroidetes,2G153@200643|Bacteroidia 976|Bacteroidetes T PAS domain - - - - - - - - - - - - GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg k59_48627_1 1117647.M5M_13023 6.12e-180 536.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1030339_1 555500.I215_09421 4.97e-06 53.5 COG0860@1|root,COG0860@2|Bacteria,4NHTN@976|Bacteroidetes,1I0TP@117743|Flavobacteriia 976|Bacteroidetes M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,SPOR k59_12537_1 326298.Suden_1835 5.62e-102 301.0 COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,42MYE@68525|delta/epsilon subdivisions,2YMF4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_1030345_1 765912.Thimo_1694 1.36e-40 150.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales 135613|Chromatiales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_965679_1 1500893.JQNB01000001_gene488 3.96e-39 142.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1X3US@135614|Xanthomonadales 135614|Xanthomonadales NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_965679_2 1026882.MAMP_00228 3.5e-19 84.3 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,460ZV@72273|Thiotrichales 72273|Thiotrichales NU PFAM Fimbrial assembly protein (PilN) - - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_509615_1 1049564.TevJSym_as00080 1.14e-76 238.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria,1J4YB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126,SHOCT k59_475014_1 469383.Cwoe_4226 1.07e-162 474.0 COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,4CRRH@84995|Rubrobacteria 84995|Rubrobacteria E GMC oxidoreductase - - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_311175_1 448385.sce0819 1.28e-28 120.0 COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2YUJ0@29|Myxococcales 28221|Deltaproteobacteria Q Acyl transferase domain - - - - - - - - - - - - Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_182257_1 1232437.KL662006_gene4441 4.31e-17 74.7 2EF15@1|root,338U9@2|Bacteria,1NEFE@1224|Proteobacteria,42W2B@68525|delta/epsilon subdivisions,2WSHP@28221|Deltaproteobacteria,2MKZ1@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_182257_2 1121405.dsmv_0212 2.44e-76 239.0 COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2WKRY@28221|Deltaproteobacteria,2MJ1I@213118|Desulfobacterales 28221|Deltaproteobacteria S epimerase dehydratase - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_965682_1 555778.Hneap_1105 1.48e-19 88.2 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WX8J@135613|Chromatiales 1236|Gammaproteobacteria EI Allophanate hydrolase subunit 1 uca - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_965682_2 688245.CtCNB1_1720 2.47e-41 149.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VKEV@28216|Betaproteobacteria,4AESY@80864|Comamonadaceae 28216|Betaproteobacteria I enoyl-CoA hydratase - - 4.2.1.57 ko:K13779 ko00281,map00281 - R03493 RC00941 ko00000,ko00001,ko01000 - - - ECH_1 k59_798878_2 1265505.ATUG01000003_gene627 7.07e-35 123.0 2E8UW@1|root,3335A@2|Bacteria,1N8I8@1224|Proteobacteria,42TGA@68525|delta/epsilon subdivisions,2WQAG@28221|Deltaproteobacteria,2MKHK@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_246463_1 1121898.Q766_18460 4.77e-106 323.0 COG0388@1|root,COG0388@2|Bacteria,4NEAQ@976|Bacteroidetes,1HWST@117743|Flavobacteriia,2NU5I@237|Flavobacterium 976|Bacteroidetes S Carbon-nitrogen hydrolase ramA_2 - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_704297_1 243159.AFE_1784 2.37e-50 181.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,2NCQE@225057|Acidithiobacillales 225057|Acidithiobacillales M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_933590_1 765911.Thivi_0986 3.31e-155 461.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_541762_1 1328313.DS2_07418 6.18e-23 102.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,1RPG9@1236|Gammaproteobacteria,467GZ@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase qseC - 2.7.13.3 ko:K02484,ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_475035_2 1442599.JAAN01000019_gene2375 4.3e-66 207.0 COG1670@1|root,COG1670@2|Bacteria,1RD77@1224|Proteobacteria,1SZJ4@1236|Gammaproteobacteria,1XCVI@135614|Xanthomonadales 135614|Xanthomonadales J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_769528_1 3827.XP_004516946.1 8.47e-31 119.0 COG1008@1|root,KOG4845@2759|Eukaryota,37QQT@33090|Viridiplantae,3G7MJ@35493|Streptophyta,4JSGR@91835|fabids 35493|Streptophyta C NAD(P)H-quinone oxidoreductase chain 4 ndhD - 1.6.5.3 ko:K05575 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Proton_antipo_M k59_798911_1 1168034.FH5T_09335 9.13e-64 215.0 COG4704@1|root,COG4704@2|Bacteria,4NGPF@976|Bacteroidetes,2FNAC@200643|Bacteroidia 976|Bacteroidetes S Bacterial Ig-like domain - - - - - - - - - - - - Big_5,fn3_3 k59_900352_1 1120973.AQXL01000115_gene659 7.51e-110 337.0 COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,4H9R4@91061|Bacilli,2784N@186823|Alicyclobacillaceae 91061|Bacilli M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_798915_1 1536769.P40081_13290 1.91e-07 58.9 COG0236@1|root,COG3319@1|root,COG0236@2|Bacteria,COG3319@2|Bacteria,1TVHI@1239|Firmicutes,4I2RU@91061|Bacilli,272I7@186822|Paenibacillaceae 91061|Bacilli IQ Thioesterase domain - - - ko:K13615 - - - - ko00000,ko01004,ko01008 - - - PP-binding,Thioesterase k59_639481_1 886293.Sinac_5243 6.33e-96 287.0 COG0115@1|root,COG0115@2|Bacteria,2J2GT@203682|Planctomycetes 203682|Planctomycetes H Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_769543_1 388413.ALPR1_12755 9.65e-106 334.0 COG3497@1|root,COG3497@2|Bacteria,4NEKK@976|Bacteroidetes,47KYE@768503|Cytophagia 976|Bacteroidetes S Phage tail sheath C-terminal domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_149691_1 666685.R2APBS1_1177 2.16e-52 169.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1X61R@135614|Xanthomonadales 135614|Xanthomonadales J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_149691_2 870187.Thini_1121 3.2e-08 50.4 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,460WE@72273|Thiotrichales 72273|Thiotrichales J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_541787_1 933262.AXAM01000018_gene1019 2.33e-35 134.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2MHY9@213118|Desulfobacterales 28221|Deltaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_639487_1 748247.AZKH_2496 3.25e-27 115.0 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VPRW@28216|Betaproteobacteria,2KYK5@206389|Rhodocyclales 206389|Rhodocyclales M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_639487_2 1208321.D104_13900 5.19e-39 142.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria,1XIE7@135619|Oceanospirillales 135619|Oceanospirillales C methylmalonate-semialdehyde dehydrogenase - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_867122_1 1380393.JHVP01000005_gene3591 4.8e-62 197.0 COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4EWIE@85013|Frankiales 201174|Actinobacteria S Putative esterase - - - - - - - - - - - - Esterase k59_867122_2 1122622.ATWJ01000008_gene2997 6.12e-25 102.0 COG0151@1|root,COG0151@2|Bacteria,2I7DG@201174|Actinobacteria,4FK12@85021|Intrasporangiaceae 201174|Actinobacteria F Carbamoyl-phosphate synthase L chain, ATP binding domain - - - - - - - - - - - - CPSase_L_D2 k59_83032_1 469616.FMAG_00136 2.34e-35 131.0 COG1840@1|root,COG1840@2|Bacteria,3791X@32066|Fusobacteria 32066|Fusobacteria P Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF1858,SBP_bac_6 k59_83032_2 572544.Ilyop_1864 2.44e-149 422.0 COG0378@1|root,COG0378@2|Bacteria,379PF@32066|Fusobacteria 32066|Fusobacteria KO CobW P47K family protein - - - - - - - - - - - - cobW k59_409847_1 392500.Swoo_2979 0.000927 48.5 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,2QETZ@267890|Shewanellaceae 1236|Gammaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_149701_1 1122947.FR7_4576 1.26e-38 147.0 COG4221@1|root,COG4221@2|Bacteria,1UNEP@1239|Firmicutes 1239|Firmicutes IQ oxidoreductase activity - - - - - - - - - - - - KR,PS-DH k59_546880_1 1537917.JU82_01850 1.35e-16 77.8 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2YMYB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_546880_2 1537917.JU82_01845 8.4e-43 146.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42MZF@68525|delta/epsilon subdivisions,2YMQX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_774985_1 1116472.MGMO_53c00370 3.63e-53 173.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1XE0T@135618|Methylococcales 135618|Methylococcales S Peptidase family M50 - - - - - - - - - - - - - k59_774985_2 377629.TERTU_2472 3.29e-44 150.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,2PN6D@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Telomere recombination yciO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Sua5_yciO_yrdC k59_1004433_1 1168034.FH5T_10415 6.74e-54 174.0 28MFD@1|root,2ZASV@2|Bacteria,4NH4N@976|Bacteroidetes,2FQXU@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1004433_2 1168034.FH5T_10410 6.85e-122 385.0 COG0841@1|root,COG1131@1|root,COG0841@2|Bacteria,COG1131@2|Bacteria,4NF8M@976|Bacteroidetes,2FQY7@200643|Bacteroidia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ABC_tran,ACR_tran k59_187767_1 1121918.ARWE01000001_gene1828 1.82e-74 236.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Y@68525|delta/epsilon subdivisions,2X6NA@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Domain of unknown function (DUF4372) - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_220282_1 1254432.SCE1572_30080 1.61e-19 89.0 COG0515@1|root,COG2114@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2YU18@29|Myxococcales 28221|Deltaproteobacteria KLT Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc,Pkinase k59_678186_1 697282.Mettu_2892 9.64e-15 73.6 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1XF7V@135618|Methylococcales 135618|Methylococcales M Belongs to the skp family - - - ko:K06142 - - - - ko00000 - - - OmpH k59_678186_2 187272.Mlg_2721 3.08e-09 58.9 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales 135613|Chromatiales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_415044_2 2340.JV46_16650 5.58e-67 207.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1J6EM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_546906_1 1049564.TevJSym_ah00100 4.07e-138 407.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1J5A1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_644932_1 709032.Sulku_1151 2.68e-07 52.8 COG0614@1|root,COG0614@2|Bacteria,1NVK4@1224|Proteobacteria,42MBT@68525|delta/epsilon subdivisions,2YMTN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_316549_1 545276.KB898727_gene501 1.37e-89 292.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_612372_1 1007104.SUS17_2708 1.07e-05 51.2 COG1309@1|root,COG1309@2|Bacteria,1R8KS@1224|Proteobacteria,2TSYV@28211|Alphaproteobacteria,2K6W7@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_220299_1 1049564.TevJSym_as00660 3.26e-110 344.0 COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MMPL family IV02_10640 - - ko:K07003 - - - - ko00000 - - - MMPL k59_18250_1 1304883.KI912532_gene196 4.96e-218 608.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,2KVB2@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_579109_1 264402.Cagra.3217s0018.1.p 4.25e-09 62.4 COG0625@1|root,KOG0867@2759|Eukaryota,37MNY@33090|Viridiplantae,3GH48@35493|Streptophyta,3HR92@3699|Brassicales 35493|Streptophyta O Belongs to the GST superfamily - GO:0001101,GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005507,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005829,GO:0005886,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009414,GO:0009415,GO:0009507,GO:0009536,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016740,GO:0016765,GO:0019748,GO:0030312,GO:0033218,GO:0034641,GO:0042221,GO:0042277,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043295,GO:0043603,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046686,GO:0046872,GO:0046914,GO:0048037,GO:0048046,GO:0050896,GO:0051186,GO:0071704,GO:0071944,GO:0072341,GO:0098754,GO:1900750,GO:1901564,GO:1901681,GO:1901700 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N k59_971282_1 360107.CHAB381_1291 2.99e-38 132.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,42TMC@68525|delta/epsilon subdivisions,2YPSJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FG (HIT) family - - - - - - - - - - - - HIT k59_971282_2 207954.MED92_03303 2.26e-105 315.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1XHWW@135619|Oceanospirillales 135619|Oceanospirillales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_905980_1 883114.HMPREF9709_00282 2.66e-29 118.0 COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,22GFD@1570339|Peptoniphilaceae 186801|Clostridia M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_938918_1 484019.THA_1054 8.35e-77 242.0 COG0112@1|root,COG0112@2|Bacteria,2GCND@200918|Thermotogae 200918|Thermotogae E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_938918_2 768671.ThimaDRAFT_0675 3.3e-68 230.0 COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales 135613|Chromatiales G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB - - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - hDGE_amylase k59_938918_3 572544.Ilyop_0439 2.98e-54 187.0 COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,379S8@32066|Fusobacteria 32066|Fusobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_971284_1 1121939.L861_01415 4.69e-64 203.0 COG1309@1|root,COG1309@2|Bacteria,1N1Q3@1224|Proteobacteria,1S6NF@1236|Gammaproteobacteria,1XPA5@135619|Oceanospirillales 135619|Oceanospirillales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_382792_2 1123368.AUIS01000028_gene1314 3.28e-07 50.1 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,2NCWI@225057|Acidithiobacillales 225057|Acidithiobacillales E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_187785_1 1167006.UWK_01447 7.01e-24 103.0 COG3221@1|root,COG3221@2|Bacteria,1QVNP@1224|Proteobacteria 1224|Proteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - 2.7.13.3 ko:K13040 ko02020,map02020 M00514 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GerE,Phosphonate-bd k59_155284_1 454957.IA64_06730 5.19e-66 209.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1T08S@1236|Gammaproteobacteria,1XCZE@135614|Xanthomonadales 135614|Xanthomonadales S Eukaryotic integral membrane protein (DUF1751) - - - - - - - - - - - - Rhomboid k59_644957_1 926692.AZYG01000085_gene858 1.05e-12 72.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,3WBBP@53433|Halanaerobiales 186801|Clostridia E Flavin containing amine oxidoreductase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_612399_1 610130.Closa_2760 7.03e-28 117.0 COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,223RM@1506553|Lachnoclostridium 186801|Clostridia T Diguanylate cyclase and metal dependent phosphohydrolase - - - - - - - - - - - - GGDEF,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9 k59_415073_1 497321.C664_04312 3.34e-85 268.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,2KVQ1@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_971296_1 2340.JV46_21780 2.91e-53 171.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1J70E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the small heat shock protein (HSP20) family hspA - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_316566_1 765911.Thivi_2092 3.41e-73 232.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,1WVWJ@135613|Chromatiales 135613|Chromatiales E ABC transporter, urea - - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_252032_1 1415774.U728_346 7.83e-25 99.8 COG0582@1|root,COG0582@2|Bacteria,1V2RX@1239|Firmicutes,24DD0@186801|Clostridia,36J61@31979|Clostridiaceae 186801|Clostridia L integrase family - - - - - - - - - - - - Phage_integrase k59_252032_2 526224.Bmur_0769 9.45e-20 84.0 COG1359@1|root,COG1359@2|Bacteria 2|Bacteria S Antibiotic biosynthesis monooxygenase ycnE GO:0003674,GO:0003824 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - ABM k59_316569_1 1172190.M947_10375 5.29e-86 279.0 COG0249@1|root,COG1403@1|root,COG0249@2|Bacteria,COG1403@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2YN6Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DNA mismatch repair MutS family mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_III,MutS_V k59_678204_2 1122605.KB893625_gene1733 2.46e-06 50.1 COG3119@1|root,COG3119@2|Bacteria,4NFGI@976|Bacteroidetes,1IV7H@117747|Sphingobacteriia 976|Bacteroidetes P Sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_54078_1 504728.K649_11640 1.16e-08 58.2 COG0210@1|root,COG0210@2|Bacteria,1WM1G@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_351507_1 472759.Nhal_2450 4.61e-100 317.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_938947_1 96561.Dole_0200 3.93e-65 220.0 COG2010@1|root,COG2993@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome c pcmF - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_316579_1 1380356.JNIK01000006_gene1529 1.99e-32 129.0 COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4ESG4@85013|Frankiales 201174|Actinobacteria KLT Serine threonine protein kinase pknA GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0040007,GO:0042304,GO:0043085,GO:0043086,GO:0043170,GO:0043388,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051055,GO:0051098,GO:0051099,GO:0051101,GO:0051128,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_872620_1 760192.Halhy_2665 5.68e-16 84.0 COG1028@1|root,COG1028@2|Bacteria,4NUJD@976|Bacteroidetes 976|Bacteroidetes IQ Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - - k59_612416_1 571166.KI421509_gene904 9.5e-27 104.0 COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2TU33@28211|Alphaproteobacteria 28211|Alphaproteobacteria H COG2998 ABC-type tungstate transport system, permease component tupA - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 k59_612416_2 1530186.JQEY01000001_gene1326 8.64e-42 147.0 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,2TU96@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1910, Periplasmic molybdate-binding protein domain - - - - - - - - - - - - HTH_17,PBP_like k59_775035_2 1168034.FH5T_11075 4.53e-86 257.0 COG1259@1|root,COG1259@2|Bacteria,4NGSW@976|Bacteroidetes,2FTKZ@200643|Bacteroidia 976|Bacteroidetes S Conserved protein - - - ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR k59_546981_1 1249480.B649_05865 9.12e-213 604.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2YMYX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g,tRNA_bind k59_252062_1 1384054.N790_07690 6.15e-37 139.0 COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria,1XCS6@135614|Xanthomonadales 135614|Xanthomonadales M Periplasmic protein TonB links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_971329_1 1168034.FH5T_07845 6.39e-73 230.0 COG3823@1|root,COG3823@2|Bacteria,4NF2M@976|Bacteroidetes,2FS7M@200643|Bacteroidia 976|Bacteroidetes O Glutamine cyclotransferase - - 2.3.2.5 ko:K00683 - - - - ko00000,ko01000 - - - Glu_cyclase_2 k59_906636_1 1121405.dsmv_3176 3.98e-53 184.0 COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MHP3@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 k59_775824_2 575788.VS_0203 0.000561 42.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1XSXQ@135623|Vibrionales 135623|Vibrionales D COG4942 Membrane-bound metallopeptidase envC - - - - - - - - - - - Peptidase_M23 k59_547830_1 1121405.dsmv_3072 4.97e-96 301.0 COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2MHN0@213118|Desulfobacterales 28221|Deltaproteobacteria G Phosphofructokinase pfp - 2.7.1.11,2.7.1.90 ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_516203_1 690850.Desaf_2004 6.59e-13 70.5 COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42YHK@68525|delta/epsilon subdivisions,2WUDF@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_89595_1 519989.ECTPHS_10029 2.2e-48 165.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales 135613|Chromatiales CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_220950_1 857571.EA1_08462 4.33e-129 380.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1RPM4@1236|Gammaproteobacteria,3NNVB@468|Moraxellaceae 1236|Gammaproteobacteria H COG0270 Site-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase,RE_HpaII k59_89596_1 326298.Suden_1504 1.07e-37 127.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2YPTZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K 'Cold-shock' DNA-binding domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_547844_1 385682.AFSL01000040_gene258 3.15e-76 239.0 COG0484@1|root,COG0484@2|Bacteria,4NF41@976|Bacteroidetes,2FPHH@200643|Bacteroidia,3XJEN@558415|Marinilabiliaceae 976|Bacteroidetes O DnaJ central domain dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_220955_1 522306.CAP2UW1_1272 1.17e-49 172.0 COG4313@1|root,COG4313@2|Bacteria,1PRCN@1224|Proteobacteria,2VQHT@28216|Betaproteobacteria,1KQK1@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Protein involved in meta-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_1005181_1 933262.AXAM01000132_gene1919 2.53e-40 143.0 COG1762@1|root,COG1762@2|Bacteria,1RG0Z@1224|Proteobacteria,42RSF@68525|delta/epsilon subdivisions,2WNXB@28221|Deltaproteobacteria,2MJZ1@213118|Desulfobacterales 28221|Deltaproteobacteria GT PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - HTH_17,PTS_EIIA_2 k59_547851_2 1123393.KB891332_gene2715 1.56e-21 91.7 2EFRD@1|root,339HE@2|Bacteria,1NDZX@1224|Proteobacteria,2WDJX@28216|Betaproteobacteria,1KSY3@119069|Hydrogenophilales 119069|Hydrogenophilales - - - - - - - - - - - - - - - k59_122496_1 7070.TC003231-PA 6.59e-11 66.2 KOG1695@1|root,KOG1695@2759|Eukaryota,39R3B@33154|Opisthokonta,3BJH6@33208|Metazoa,3D3HE@33213|Bilateria,41WJ0@6656|Arthropoda,3SM02@50557|Insecta 33208|Metazoa O glutathione s-transferase HPGDS GO:0000287,GO:0001516,GO:0003674,GO:0003824,GO:0004364,GO:0004601,GO:0004602,GO:0004667,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006518,GO:0006575,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0006690,GO:0006692,GO:0006693,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008285,GO:0008610,GO:0009058,GO:0009636,GO:0009987,GO:0016053,GO:0016209,GO:0016491,GO:0016684,GO:0016740,GO:0016765,GO:0016853,GO:0016860,GO:0019752,GO:0032787,GO:0033559,GO:0034641,GO:0042127,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043900,GO:0043901,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046456,GO:0046457,GO:0046872,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051239,GO:0051241,GO:0051716,GO:0055114,GO:0065007,GO:0070887,GO:0071704,GO:0072330,GO:0097237,GO:0098754,GO:0098869,GO:1901564,GO:1901568,GO:1901570,GO:1901576,GO:1905936,GO:1905937,GO:1990748,GO:2000241,GO:2000242,GO:2000254,GO:2000255 2.5.1.18,5.3.99.2 ko:K00799,ko:K04097 ko00480,ko00590,ko00980,ko00982,ko00983,ko01100,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00590,map00980,map00982,map00983,map01100,map01524,map05200,map05204,map05225,map05418 - R02266,R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00672,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_3,GST_N k59_841093_2 1319815.HMPREF0202_01653 1.86e-118 347.0 COG0573@1|root,COG0573@2|Bacteria,3795Q@32066|Fusobacteria 32066|Fusobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_906659_1 319236.JCM19294_39 3.17e-37 131.0 COG0454@1|root,COG0456@2|Bacteria,4NQDY@976|Bacteroidetes,1I23P@117743|Flavobacteriia 976|Bacteroidetes K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_1005191_1 246194.CHY_1159 1.24e-55 194.0 COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,42EM0@68295|Thermoanaerobacterales 186801|Clostridia D PFAM cell divisionFtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_516242_1 338963.Pcar_0451 4.88e-44 150.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,43UX2@69541|Desulfuromonadales 28221|Deltaproteobacteria Q MlaC protein - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_516242_2 1123073.KB899241_gene3135 1.17e-17 81.3 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1S1PR@1236|Gammaproteobacteria,1X4CU@135614|Xanthomonadales 135614|Xanthomonadales Q abc transporter atp-binding protein - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1036598_1 595460.RRSWK_06783 4.83e-121 372.0 COG2304@1|root,COG2304@2|Bacteria,2IY1T@203682|Planctomycetes 203682|Planctomycetes S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA,VWA_3 k59_481088_1 501479.ACNW01000060_gene2644 1.63e-19 94.0 COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Cadherin,Calx-beta,HemolysinCabind,LTD,Peptidase_M10,Peptidase_M10_C,W_rich_C k59_415827_1 997346.HMPREF9374_0704 1.78e-82 262.0 COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,4HA7F@91061|Bacilli,27B5M@186824|Thermoactinomycetaceae 91061|Bacilli K NusA-like KH domain nusA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k59_448419_1 1168034.FH5T_12650 2.12e-79 240.0 COG0526@1|root,COG0526@2|Bacteria,4P3HC@976|Bacteroidetes,2FYG2@200643|Bacteroidia 976|Bacteroidetes CO Thioredoxin - - - - - - - - - - - - AhpC-TSA k59_258327_5 1408422.JHYF01000004_gene1557 1.74e-144 416.0 COG0395@1|root,COG0395@2|Bacteria,1TSYB@1239|Firmicutes,24AKM@186801|Clostridia,36HHP@31979|Clostridiaceae 186801|Clostridia G inner membrane component - - - ko:K10194 ko02010,map02010 M00202 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.11 - - BPD_transp_1 k59_258327_6 1319815.HMPREF0202_02220 5.88e-159 451.0 COG1175@1|root,COG1175@2|Bacteria,379SM@32066|Fusobacteria 32066|Fusobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K10193 ko02010,map02010 M00202 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.11 - - BPD_transp_1 k59_421688_1 1163671.JAGI01000001_gene354 9.92e-22 97.1 COG1262@1|root,COG1262@2|Bacteria,1V2AE@1239|Firmicutes,25BEC@186801|Clostridia,36WET@31979|Clostridiaceae 186801|Clostridia S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase k59_586793_2 1246448.ANAZ01000008_gene2404 3.87e-17 82.8 COG1309@1|root,COG1309@2|Bacteria,2INBA@201174|Actinobacteria,4EKVN@85012|Streptosporangiales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_456128_1 861299.J421_0814 3.12e-72 231.0 COG1454@1|root,COG1454@2|Bacteria 2|Bacteria C hydroxyacid-oxoacid transhydrogenase activity CT0951 - 1.1.1.1,4.3.3.7 ko:K00001,ko:K01714 ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230 M00016,M00525,M00526,M00527 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - Fe-ADH k59_421696_1 1168034.FH5T_13690 1.2e-30 115.0 COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,2FMGP@200643|Bacteroidia 976|Bacteroidetes S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_978202_1 1158338.JNLJ01000001_gene864 2.81e-92 291.0 COG2244@1|root,COG2244@2|Bacteria,2G4RS@200783|Aquificae 200783|Aquificae S Polysaccharide biosynthesis protein - - - - - - - - - - - - MatE,Polysacc_synt,Polysacc_synt_C k59_978202_2 563040.Saut_0263 4.87e-128 368.0 COG0529@1|root,COG0529@2|Bacteria,1R6CM@1224|Proteobacteria,42PPR@68525|delta/epsilon subdivisions,2YTS4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Catalyzes the synthesis of activated sulfate - - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,DUF2061 k59_1011235_1 1123269.NX02_28175 2.34e-08 59.7 COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,2U7N2@28211|Alphaproteobacteria,2K1WW@204457|Sphingomonadales 204457|Sphingomonadales T COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - 3.1.3.16 ko:K07313 - - - - ko00000,ko01000 - - - Metallophos k59_391349_1 484770.UFO1_1752 1.27e-34 132.0 COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4H3R9@909932|Negativicutes 909932|Negativicutes C PFAM NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN k59_879530_1 568706.BN118_2864 1.1e-53 175.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,3T2J4@506|Alcaligenaceae 28216|Betaproteobacteria S Phospholipid-binding protein ybhB - - ko:K06910 - - - - ko00000 - - - PBP k59_879530_2 549.BW31_03544 6.58e-08 54.7 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,3VYDH@53335|Pantoea 1236|Gammaproteobacteria H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008412,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - iZ_1308.Z5639 UbiA k59_912582_1 1089552.KI911559_gene671 5.21e-24 93.2 2E8PT@1|root,3330W@2|Bacteria,1N796@1224|Proteobacteria,2UG2Y@28211|Alphaproteobacteria,2JU15@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_912582_2 867845.KI911784_gene3486 2.91e-08 53.5 2E5VC@1|root,330JE@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_747864_1 583355.Caka_1127 5.38e-29 108.0 2E5IJ@1|root,3309Y@2|Bacteria,46SYV@74201|Verrucomicrobia,3K87A@414999|Opitutae 414999|Opitutae - - - - - - - - - - - - - - - k59_1043529_1 1301098.PKB_4585 9.78e-30 118.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Involved in formation and maintenance of cell shape mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963 - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_128759_1 387093.SUN_2335 9.21e-38 129.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2YT0H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_128759_2 387093.SUN_2333 3.13e-120 344.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2YN2M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_290189_1 1168034.FH5T_05720 5.95e-18 83.2 2DB82@1|root,2Z7PX@2|Bacteria,4NEW5@976|Bacteroidetes,2FMDV@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - Beta_helix k59_290189_2 1429046.RR21198_0311 0.00039 46.6 COG2374@1|root,COG2374@2|Bacteria,2I8IB@201174|Actinobacteria,4G6C0@85025|Nocardiaceae 201174|Actinobacteria L Endonuclease Exonuclease Phosphatase - - - - - - - - - - - - Exo_endo_phos k59_61540_1 93220.LV28_12450 9.77e-74 234.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,1K08M@119060|Burkholderiaceae 28216|Betaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_61540_2 272624.lpg2705 3.82e-38 133.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1JC5R@118969|Legionellales 118969|Legionellales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_685518_1 1122201.AUAZ01000009_gene2763 2.41e-28 108.0 COG4665@1|root,COG4665@2|Bacteria,1RE14@1224|Proteobacteria,1S582@1236|Gammaproteobacteria,46AGS@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_685518_2 626887.J057_05696 1.62e-26 108.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,46AE2@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM,DctQ k59_227498_1 563040.Saut_0423 8.49e-162 461.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42QA8@68525|delta/epsilon subdivisions,2YNH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA_3 k59_358352_2 1355368.JART01000019_gene1130 6.81e-23 107.0 COG3409@1|root,COG3409@2|Bacteria,1N3E4@1224|Proteobacteria,42TDC@68525|delta/epsilon subdivisions 1224|Proteobacteria M Putative peptidoglycan binding domain - - - - - - - - - - - - PG_binding_1 k59_586814_2 977880.RALTA_A0686 1.18e-33 129.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,1K0EM@119060|Burkholderiaceae 28216|Betaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_651826_1 749222.Nitsa_0338 5.04e-73 224.0 COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,42RGX@68525|delta/epsilon subdivisions,2YPA8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TIGRFAM DJ-1 family protein thiJ - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_61550_1 572477.Alvin_1309 1.17e-91 275.0 2A5PE@1|root,30UE9@2|Bacteria,1PX3T@1224|Proteobacteria,1TA9Y@1236|Gammaproteobacteria,1WZSR@135613|Chromatiales 135613|Chromatiales M Protein of unknown function (DUF3313) - - - - - - - - - - - - DUF3313 k59_1011251_1 1168034.FH5T_12085 8.87e-105 313.0 COG0104@1|root,COG0104@2|Bacteria,4NGRZ@976|Bacteroidetes,2FM8A@200643|Bacteroidia 976|Bacteroidetes F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_486864_1 396588.Tgr7_3246 3.71e-72 241.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WX2G@135613|Chromatiales 135613|Chromatiales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_1043540_1 1122951.ATUE01000012_gene518 5.57e-101 325.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,3NIMH@468|Moraxellaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_95650_2 519989.ECTPHS_02531 2.51e-37 143.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales 135613|Chromatiales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_912601_1 1410670.JHXF01000001_gene2567 2.04e-14 67.8 COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia,3WKGN@541000|Ruminococcaceae 186801|Clostridia S Could be involved in insertion of integral membrane proteins into the membrane yidD - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_912601_2 395493.BegalDRAFT_1138 1.51e-34 135.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,45ZXV@72273|Thiotrichales 72273|Thiotrichales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_522859_1 483215.BACFIN_08774 2.4e-30 126.0 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NIEK@976|Bacteroidetes,2FMAP@200643|Bacteroidia,4AKI4@815|Bacteroidaceae 976|Bacteroidetes T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_586822_1 709032.Sulku_0714 1.74e-248 699.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42N29@68525|delta/epsilon subdivisions,2YMFM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA helicase rep - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_946356_2 706587.Desti_0293 1.16e-29 111.0 COG1633@1|root,COG1633@2|Bacteria,1N4PW@1224|Proteobacteria,42UZG@68525|delta/epsilon subdivisions,2WNGQ@28221|Deltaproteobacteria,2MS9U@213462|Syntrophobacterales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_978222_1 1342301.JASD01000008_gene3598 4.63e-11 69.7 COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3ZUZ8@60136|Sulfitobacter 28211|Alphaproteobacteria Q Hint domain - - - - - - - - - - - - HemolysinCabind,Hint_2 k59_391358_1 1168034.FH5T_01030 1.08e-169 481.0 COG4806@1|root,COG4806@2|Bacteria,4NHKW@976|Bacteroidetes,2FNVS@200643|Bacteroidia 976|Bacteroidetes G Psort location Cytoplasmic, score 8.96 rhaA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008740,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.14 ko:K01813 ko00051,ko01120,map00051,map01120 - R02437 RC00434 ko00000,ko00001,ko01000 - - - RhaA k59_25497_1 743299.Acife_0281 2.69e-34 133.0 COG2885@1|root,COG2885@2|Bacteria,1R4CA@1224|Proteobacteria,1S37I@1236|Gammaproteobacteria,2NDGC@225057|Acidithiobacillales 225057|Acidithiobacillales M OmpA family - - - - - - - - - - - - OmpA k59_195287_1 83406.HDN1F_29020 5.26e-118 352.0 2CBBK@1|root,2ZADC@2|Bacteria,1R4ED@1224|Proteobacteria,1RS9S@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_522872_1 1249627.D779_1197 3.9e-128 387.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales 135613|Chromatiales G PFAM Alpha amylase, catalytic - - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_25503_1 1168034.FH5T_00815 4e-124 369.0 COG3507@1|root,COG3507@2|Bacteria,4NFXE@976|Bacteroidetes,2FNGR@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family xynBA - - - - - - - - - - - Glyco_hydro_43 k59_486880_1 317655.Sala_1587 1.76e-24 105.0 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,2TVNU@28211|Alphaproteobacteria,2K98T@204457|Sphingomonadales 204457|Sphingomonadales GM NAD(P)H-binding - - - - - - - - - - - - Epimerase k59_421740_1 926550.CLDAP_25100 7.75e-17 78.6 COG0221@1|root,COG0221@2|Bacteria,2G6T4@200795|Chloroflexi 200795|Chloroflexi C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_421740_2 381666.H16_B2032 4.35e-29 111.0 COG1192@1|root,COG1192@2|Bacteria,1MVEZ@1224|Proteobacteria,2VK7W@28216|Betaproteobacteria,1K50X@119060|Burkholderiaceae 28216|Betaproteobacteria D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_61583_1 1089447.RHAA1_01009 4.4e-94 305.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1Y7XT@135625|Pasteurellales 135625|Pasteurellales EGIPQ Phosphate acyltransferases - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_391373_1 749222.Nitsa_2075 9.82e-73 228.0 COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,42MQ9@68525|delta/epsilon subdivisions,2YTBB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Arginosuccinate synthase - - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - Arginosuc_synth,ThiI,tRNA_Me_trans k59_128769_1 1049564.TevJSym_ab01040 2e-285 802.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1J4DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_128769_3 1307759.JOMJ01000003_gene1961 6.01e-47 157.0 COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,42SVE@68525|delta/epsilon subdivisions,2WN0M@28221|Deltaproteobacteria,2MD10@213115|Desulfovibrionales 28221|Deltaproteobacteria LU Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier k59_128769_4 62928.azo3614 1.8e-16 76.6 2E7KC@1|root,3025Q@2|Bacteria,1PUPZ@1224|Proteobacteria,2VXH0@28216|Betaproteobacteria,2KZAR@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_128769_5 1049564.TevJSym_ad01570 7.95e-21 94.4 2EC19@1|root,3360G@2|Bacteria,1PBYU@1224|Proteobacteria,1SD34@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidoglycan-binding protein, CsiV - - - - - - - - - - - - CsiV k59_128769_6 1049564.TevJSym_ad01580 0.0 1604.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J4G0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_128769_7 331678.Cphamn1_0514 9.41e-43 157.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - HemolysinCabind k59_456176_1 1178482.BJB45_02655 1.08e-18 84.0 COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,1S6UR@1236|Gammaproteobacteria,1XJU3@135619|Oceanospirillales 135619|Oceanospirillales L COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_456176_2 858619.CVAR_1138 1.05e-24 107.0 COG0791@1|root,COG3599@1|root,COG0791@2|Bacteria,COG3599@2|Bacteria,2GIWB@201174|Actinobacteria,22K9D@1653|Corynebacteriaceae 201174|Actinobacteria M Cell wall-associated hydrolases - GO:0005575,GO:0005576 - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 k59_128770_1 1408473.JHXO01000007_gene707 2.69e-102 300.0 COG0785@1|root,COG0785@2|Bacteria,4PKGI@976|Bacteroidetes,2G3GF@200643|Bacteroidia 976|Bacteroidetes O cytochrome c biogenesis protein - - - - - - - - - - - - DsbD_2 k59_128770_2 1408473.JHXO01000007_gene708 7.74e-53 169.0 2E9PV@1|root,333W7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_128770_3 1168034.FH5T_14810 2.69e-29 106.0 COG0526@1|root,COG0526@2|Bacteria,4NUP1@976|Bacteroidetes,2FUJZ@200643|Bacteroidia 976|Bacteroidetes CO redox-active disulfide protein 2 - - - - - - - - - - - - Thioredoxin_3 k59_586846_1 1303518.CCALI_01677 8.37e-47 166.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups wbdA - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_128771_1 1430440.MGMSRv2_3272 3.08e-46 164.0 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,2V6MG@28211|Alphaproteobacteria,2JQTK@204441|Rhodospirillales 204441|Rhodospirillales G xylanase chitin deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_685567_1 1319815.HMPREF0202_01337 3.05e-125 376.0 2DBMQ@1|root,2Z9ZP@2|Bacteria 2|Bacteria S Conserved TM helix - - - - - - - - - - - - TM_helix k59_747906_1 1260251.SPISAL_01180 0.000351 42.4 COG0475@1|root,COG1226@1|root,COG3273@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,COG3273@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales 135613|Chromatiales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_747906_2 1205753.A989_09121 1.31e-64 209.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,1RNTW@1236|Gammaproteobacteria,1X41K@135614|Xanthomonadales 135614|Xanthomonadales F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp,Epimerase k59_61595_1 519989.ECTPHS_11807 5.48e-78 251.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_61596_1 1504822.CCNO01000015_gene767 3.13e-17 86.7 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria 2|Bacteria C formate dehydrogenase (NAD+) activity bzdV - 1.97.1.9 ko:K12527 ko00450,map00450 - R07229 RC02420 ko00000,ko00001,ko01000 - - - Complex1_30kDa,Fer2_4,Fer4,Fer4_20,Fer4_7,NADH-G_4Fe-4S_3,NADH_4Fe-4S,Pyr_redox_2 k59_163325_1 1095769.CAHF01000015_gene2756 1.75e-80 255.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VPTU@28216|Betaproteobacteria,473II@75682|Oxalobacteraceae 28216|Betaproteobacteria G FGGY family of carbohydrate kinases, C-terminal domain xylB2 - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_128780_1 1537917.JU82_11855 2.01e-101 317.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2YMJY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1g k59_421762_1 1112212.JH584235_gene253 9.74e-61 211.0 2CDRA@1|root,2Z7QN@2|Bacteria,1MVUW@1224|Proteobacteria,2U186@28211|Alphaproteobacteria,2K1FC@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_25516_1 1385515.N791_02645 1.18e-26 106.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1X3FD@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_747908_1 596151.DesfrDRAFT_0170 1.89e-209 596.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,42SDU@68525|delta/epsilon subdivisions,2WQ2F@28221|Deltaproteobacteria,2MCVQ@213115|Desulfovibrionales 28221|Deltaproteobacteria H C-5 cytosine-specific DNA methylase dcm - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_747908_2 596151.DesfrDRAFT_0169 3.16e-31 121.0 2ANHD@1|root,31DG6@2|Bacteria,1NTZK@1224|Proteobacteria,436Q8@68525|delta/epsilon subdivisions,2X1CI@28221|Deltaproteobacteria,2MESC@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of unknown function (DUF3883) - - - - - - - - - - - - DUF3883 k59_486899_1 1168034.FH5T_03000 1.73e-49 164.0 COG0847@1|root,COG0847@2|Bacteria,4NE82@976|Bacteroidetes,2FMQF@200643|Bacteroidia 976|Bacteroidetes L DNA polymerase III dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_486899_2 1168034.FH5T_03005 1.84e-187 527.0 COG0592@1|root,COG0592@2|Bacteria,4NESB@976|Bacteroidetes,2FMPF@200643|Bacteroidia 976|Bacteroidetes L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_128788_1 1121918.ARWE01000001_gene2133 1.04e-07 58.9 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,43U84@69541|Desulfuromonadales 28221|Deltaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_619777_1 1450525.JATV01000021_gene1473 1.25e-71 228.0 COG0282@1|root,COG0282@2|Bacteria,4NFI0@976|Bacteroidetes,1HYDJ@117743|Flavobacteriia,2NUGA@237|Flavobacterium 976|Bacteroidetes C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_163338_1 1117647.M5M_01710 6.85e-35 132.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1J4Y1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_811641_2 1004785.AMBLS11_04085 1.11e-15 78.6 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,46ABP@72275|Alteromonadaceae 1236|Gammaproteobacteria P receptor - - - - - - - - - - - - Plug,STN,TonB_dep_Rec k59_847071_1 706587.Desti_3092 5.84e-74 237.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WNAS@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Trypsin - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_95700_1 1168034.FH5T_05405 1.79e-120 352.0 COG0252@1|root,COG0252@2|Bacteria,4NE2Z@976|Bacteroidetes,2FM3E@200643|Bacteroidia 976|Bacteroidetes EJ L-asparaginase, type I ansA - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_619781_1 768671.ThimaDRAFT_1752 5.94e-119 357.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_619781_2 272844.PAB0495 9.79e-51 173.0 COG0649@1|root,arCOG01548@2157|Archaea,2XTWF@28890|Euryarchaeota,243G8@183968|Thermococci 183968|Thermococci C Belongs to the complex I 49 kDa subunit family - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_591410_41 78398.KS43_21825 1.47e-99 325.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,1RN0Q@1236|Gammaproteobacteria,1MQY0@122277|Pectobacterium 1236|Gammaproteobacteria T EAL domain protein lapD - - - - - - - - - - - EAL,GGDEF,HAMP,LapD_MoxY_N k59_591410_42 686340.Metal_3586 4.8e-70 221.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,1S3Y1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Periplasmic Protein - - - - - - - - - - - - Peptidase_C93 k59_591410_43 1049564.TevJSym_af00620 1.27e-313 866.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1J4UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_591410_44 572477.Alvin_1216 9.44e-108 311.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1WX8R@135613|Chromatiales 135613|Chromatiales I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_591410_45 626887.J057_14330 1.55e-67 218.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,466SM@72275|Alteromonadaceae 1236|Gammaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_591410_47 1049564.TevJSym_af00790 8.3e-133 394.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1J640@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Virulence factor BrkB rbn GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_591410_48 1216007.AOPM01000008_gene1366 1.62e-50 171.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,2PZJ0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L Belongs to the DnaA family. HdA subfamily hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_591410_49 572477.Alvin_1635 4.36e-61 194.0 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1WY27@135613|Chromatiales 135613|Chromatiales I PFAM CDP-alcohol phosphatidyltransferase - - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_591410_50 1249627.D779_2185 4.51e-180 509.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1WWGF@135613|Chromatiales 135613|Chromatiales F PFAM AIR synthase related protein purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_591410_51 765910.MARPU_07890 2.4e-88 267.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales 135613|Chromatiales F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_591410_53 754436.JCM19237_2332 1.26e-50 166.0 COG2131@1|root,COG2131@2|Bacteria,1NC75@1224|Proteobacteria,1S1U2@1236|Gammaproteobacteria,1XU6F@135623|Vibrionales 135623|Vibrionales F deoxycytidylate deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_591410_54 2340.JV46_03000 1.74e-70 222.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1J5GV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm2 - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_591410_55 1049564.TevJSym_bf00160 6.66e-35 127.0 28P01@1|root,338A2@2|Bacteria,1NBSK@1224|Proteobacteria,1SS2R@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_591410_56 111781.Lepto7376_2301 6.33e-51 167.0 COG0515@1|root,COG0515@2|Bacteria,1GGNA@1117|Cyanobacteria 1117|Cyanobacteria KLT serine threonine protein kinase - - - - - - - - - - - - - k59_591410_57 1236541.BALL01000101_gene5114 6.73e-27 121.0 COG2304@1|root,COG2304@2|Bacteria,1QU09@1224|Proteobacteria,1T39R@1236|Gammaproteobacteria,2QEWG@267890|Shewanellaceae 1236|Gammaproteobacteria S oxidoreductase activity - - - - - - - - - - - - Cadherin,He_PIG k59_983989_1 397290.C810_04123 7.53e-36 130.0 COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,27IHM@186928|unclassified Lachnospiraceae 186801|Clostridia O PPIC-type PPIASE domain prsA2 - 5.2.1.8 ko:K03769,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 k59_428148_1 745310.G432_02915 4.88e-63 205.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,2K2F3@204457|Sphingomonadales 204457|Sphingomonadales O COG0330 Membrane protease subunits, stomatin prohibitin homologs qmcA - - - - - - - - - - - Band_7,Band_7_C k59_559575_1 546275.FUSPEROL_00237 1.53e-10 64.3 COG3950@1|root,COG3950@2|Bacteria,3785E@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - AAA_15,AAA_21 k59_493987_1 1168034.FH5T_06495 1.41e-75 233.0 COG0287@1|root,COG0287@2|Bacteria,4NEKF@976|Bacteroidetes,2FS5B@200643|Bacteroidia 976|Bacteroidetes E Prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_493987_2 1408473.JHXO01000001_gene2071 2.66e-11 63.2 COG2876@1|root,COG2876@2|Bacteria,4NDU4@976|Bacteroidetes,2FPF1@200643|Bacteroidia 976|Bacteroidetes E 3-deoxy-7-phosphoheptulonate synthase pheB - 5.4.99.5 ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,DAHP_synth_1 k59_35807_1 338963.Pcar_0532 7.16e-50 170.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_167341_1 1405.DJ92_3266 7.6e-16 72.8 COG1226@1|root,COG1226@2|Bacteria,1VCJJ@1239|Firmicutes,4HM5T@91061|Bacilli,1ZHZW@1386|Bacillus 91061|Bacilli P Ion channel - - - - - - - - - - - - Ion_trans_2 k59_167341_2 1121127.JAFA01000053_gene305 2.56e-08 56.2 COG2207@1|root,COG2207@2|Bacteria,1R53W@1224|Proteobacteria,2VREY@28216|Betaproteobacteria,1KIFX@119060|Burkholderiaceae 28216|Betaproteobacteria K AraC-binding-like domain - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_362999_1 575540.Isop_0993 1.38e-25 111.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXDF@203682|Planctomycetes 575540.Isop_0993|- KLT Protein kinase domain - - 2.7.11.1 ko:K08884 - - - - ko00000,ko01000,ko01001 - - - - k59_624584_2 194439.CT0572.1 5.59e-12 66.6 2EBWM@1|root,335VW@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_35808_1 981384.AEYW01000028_gene4249 5.19e-75 235.0 COG1409@1|root,COG1409@2|Bacteria,1NI34@1224|Proteobacteria 1224|Proteobacteria S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_526790_1 1382315.JPOI01000001_gene1708 2.3e-12 73.2 COG0608@1|root,COG4199@1|root,COG0608@2|Bacteria,COG4199@2|Bacteria,1TPXE@1239|Firmicutes,4H9UP@91061|Bacilli,1WE5V@129337|Geobacillus 91061|Bacilli L Single-strand DNA-specific exonuclease, C terminal domain recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1,ssDNA-exonuc_C k59_526790_2 517417.Cpar_0705 1.88e-11 70.9 COG5523@1|root,COG5523@2|Bacteria,1FEN5@1090|Chlorobi 1090|Chlorobi S integral membrane protein - - - - - - - - - - - - - k59_526790_3 1132509.C447_08760 5.25e-12 65.5 COG0328@1|root,arCOG02942@2157|Archaea,2XT22@28890|Euryarchaeota,23SG6@183963|Halobacteria 183963|Halobacteria L COG0328 Ribonuclease HI rnhA2 - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RVT_3 k59_885687_1 929558.SMGD1_2159 2.41e-40 148.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2YNTT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,TPR_8,VWA_2 k59_885687_2 563040.Saut_0682 3.09e-49 166.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2YP1P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_591417_1 519989.ECTPHS_07416 2.81e-62 201.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales 135613|Chromatiales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_1016775_1 398527.Bphyt_3950 2.77e-19 87.8 COG1846@1|root,COG1846@2|Bacteria,1N7BV@1224|Proteobacteria,2VU53@28216|Betaproteobacteria,1KFP8@119060|Burkholderiaceae 28216|Betaproteobacteria K PFAM regulatory protein, MarR marR_1 - - - - - - - - - - - MarR,MarR_2 k59_1016775_2 1395516.PMO01_16495 4.2e-09 60.1 COG1538@1|root,COG1538@2|Bacteria,1MUZZ@1224|Proteobacteria,1RQEP@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU RND efflux system, outer membrane lipoprotein mdtP - - - - - - - - - - - OEP k59_983999_1 467661.RKLH11_3922 6.12e-45 149.0 COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_3 k59_363002_1 580332.Slit_1670 7.01e-47 161.0 COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,2W0RY@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - - k59_331282_1 1442598.JABW01000028_gene979 1.15e-81 264.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2YM8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_494622_1 1537917.JU82_11815 2.41e-71 221.0 COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,42R60@68525|delta/epsilon subdivisions,2YNZM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulatory protein, C terminal - - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_788506_1 105559.Nwat_0753 5.13e-20 89.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_788506_2 292415.Tbd_1520 2.54e-45 159.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2VI7V@28216|Betaproteobacteria,1KRDQ@119069|Hydrogenophilales 119069|Hydrogenophilales C Domain of unknown function (DUF1730) - - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_658325_2 504472.Slin_2383 6.38e-38 139.0 COG0758@1|root,COG0758@2|Bacteria,4NF7T@976|Bacteroidetes,47M2T@768503|Cytophagia 976|Bacteroidetes LU TIGRFAM DNA protecting protein DprA dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A,HHH_5 k59_853999_1 396588.Tgr7_0991 1.52e-92 282.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_723131_1 1906.SFRA_18065 7.95e-15 80.9 COG0515@1|root,COG0515@2|Bacteria,2IAZC@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_200006_1 378806.STAUR_0749 6.25e-19 82.8 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,43BC6@68525|delta/epsilon subdivisions,2X5GM@28221|Deltaproteobacteria,2YU51@29|Myxococcales 28221|Deltaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_592019_1 383372.Rcas_3954 9.47e-46 160.0 COG0530@1|root,COG0530@2|Bacteria,2G6GV@200795|Chloroflexi,376V8@32061|Chloroflexia 32061|Chloroflexia P PFAM sodium calcium exchanger membrane region - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_919795_1 1049564.TevJSym_br00030 1.85e-149 434.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,Fer4_7,Fer4_8,RnfC_N,SLBB k59_658326_1 1198232.CYCME_1071 6.46e-11 67.8 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,460N8@72273|Thiotrichales 72273|Thiotrichales NU TIGRFAM FimV C-terminal domain - - - ko:K08086 - - - - ko00000 - - - LysM k59_69346_1 1049564.TevJSym_ah00710 8.7e-95 286.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1J4GT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_297978_1 240015.ACP_0893 1.63e-08 56.6 COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,3Y3YU@57723|Acidobacteria,2JIXB@204432|Acidobacteriia 204432|Acidobacteriia T Two component regulator propeller - - - - - - - - - - - - GGDEF,Reg_prop,Y_Y_Y k59_984570_1 1168034.FH5T_05125 7.23e-119 348.0 COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,2FNG4@200643|Bacteroidia 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Acetyltransf_1 k59_919800_2 1234364.AMSF01000085_gene2961 3.95e-24 92.8 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,1X7FD@135614|Xanthomonadales 135614|Xanthomonadales J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_919800_3 270374.MELB17_20446 4.68e-25 101.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,465FN@72275|Alteromonadaceae 1236|Gammaproteobacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_1017348_1 483216.BACEGG_01535 5.66e-27 108.0 COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,2FNXT@200643|Bacteroidia,4AKTD@815|Bacteroidaceae 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1017348_2 226186.BT_0371 8.37e-71 228.0 COG0738@1|root,COG0738@2|Bacteria,4NEPI@976|Bacteroidetes,2FP0B@200643|Bacteroidia,4ANX8@815|Bacteroidaceae 976|Bacteroidetes G Transporter, major facilitator family protein gluP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_723145_1 1122603.ATVI01000006_gene543 9.67e-49 173.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1X49W@135614|Xanthomonadales 135614|Xanthomonadales S mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth uup - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_102471_2 90814.KL370891_gene255 2.47e-17 76.6 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,460PX@72273|Thiotrichales 72273|Thiotrichales J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_788528_1 1249627.D779_3295 6.4e-33 122.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales 135613|Chromatiales S Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_788528_2 697282.Mettu_3663 2.06e-21 93.6 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1XEF5@135618|Methylococcales 135618|Methylococcales P Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_919813_1 1150621.SMUL_2191 1.02e-50 173.0 COG3658@1|root,COG3658@2|Bacteria,1REFV@1224|Proteobacteria,42Q0G@68525|delta/epsilon subdivisions,2YN98@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome - - - - - - - - - - - - DHC,Ni_hydr_CYTB k59_919813_2 1454004.AW11_00618 5.61e-17 79.0 COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,2VU1H@28216|Betaproteobacteria,1KR6G@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Dihaem cytochrome c - - - - - - - - - - - - DHC k59_396418_1 1408439.JHXW01000002_gene603 1.52e-70 232.0 COG2872@1|root,COG2872@2|Bacteria,378VY@32066|Fusobacteria 32066|Fusobacteria S Threonyl and Alanyl tRNA synthetase second additional domain - - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA_SAD k59_984577_1 1291050.JAGE01000001_gene638 2.09e-36 140.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,3WGDE@541000|Ruminococcaceae 186801|Clostridia NU type II secretion system protein E xcpR - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_984577_2 572544.Ilyop_0684 1.35e-55 177.0 COG1051@1|root,COG1051@2|Bacteria,37ASE@32066|Fusobacteria 32066|Fusobacteria F Hydrolase, NUDIX family - - - - - - - - - - - - NUDIX k59_363655_1 1319815.HMPREF0202_01423 4.28e-163 482.0 COG0013@1|root,COG0013@2|Bacteria,378SD@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_363655_2 572544.Ilyop_0360 1.81e-144 410.0 COG1137@1|root,COG1137@2|Bacteria,379CC@32066|Fusobacteria 32066|Fusobacteria S K06861 lipopolysaccharide export system ATP-binding protein lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_2800_1 1537917.JU82_02820 1.07e-120 356.0 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,42MB5@68525|delta/epsilon subdivisions,2YMRI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E phospho-2-dehydro-3-deoxyheptonate aldolase aroG - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0134 DAHP_synth_2 k59_788534_1 497321.C664_06253 1.7e-84 259.0 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VX1Q@28216|Betaproteobacteria 28216|Betaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_854029_2 563040.Saut_0427 3.9e-35 128.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,42ME7@68525|delta/epsilon subdivisions,2YMBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG membrane - - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA k59_1017373_1 557598.LHK_00876 1.32e-52 172.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VHMC@28216|Betaproteobacteria,2KQT7@206351|Neisseriales 206351|Neisseriales S Metallo-beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k59_2806_1 95619.PM1_0213410 9.72e-20 89.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria 1236|Gammaproteobacteria L nucleotidyltransferase DNA polymerase involved in DNA repair imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_2806_2 859657.RPSI07_mp0735 1.44e-26 108.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1K1R9@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_168063_1 96561.Dole_1568 1.24e-68 213.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,2MJQ6@213118|Desulfobacterales 28221|Deltaproteobacteria EH TIGRFAM glutamine amidotransferase of anthranilate synthase trpG - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2496 GATase k59_69359_1 1476973.JMMB01000007_gene526 4.53e-66 215.0 COG1362@1|root,COG1362@2|Bacteria,1TQ3Z@1239|Firmicutes,248UP@186801|Clostridia,25QMP@186804|Peptostreptococcaceae 186801|Clostridia E M18 family aminopeptidase apeB - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k59_69359_2 1183438.GKIL_1904 3.28e-78 241.0 COG0745@1|root,COG0745@2|Bacteria,1G16W@1117|Cyanobacteria 1117|Cyanobacteria K Two component transcriptional regulator, Winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C k59_69359_3 237368.SCABRO_03068 1.38e-39 156.0 COG0642@1|root,COG2205@2|Bacteria,2IYV4@203682|Planctomycetes 203682|Planctomycetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_69359_4 469618.FVAG_01905 1.9e-10 56.6 2E5NE@1|root,33G3I@2|Bacteria,37B5Z@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_69359_5 1319815.HMPREF0202_00064 5.47e-86 283.0 COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3784G@32066|Fusobacteria 32066|Fusobacteria I acyl carrier protein - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,Acyltransferase,PP-binding k59_233016_1 3712.Bo5g098620.1 1.99e-07 50.8 2E7CP@1|root,2R1P8@2759|Eukaryota,383D7@33090|Viridiplantae,3GWXB@35493|Streptophyta,3I19M@3699|Brassicales 35493|Streptophyta - - - - - - - - - - - - - - - k59_233016_2 59689.scaffold_104087.1 3.53e-104 324.0 2CMQD@1|root,2QRDV@2759|Eukaryota,37QIN@33090|Viridiplantae,3GEA1@35493|Streptophyta,3HZ76@3699|Brassicales 35493|Streptophyta O function. Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis ycf2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0009507,GO:0009526,GO:0009536,GO:0009941,GO:0015031,GO:0015833,GO:0016020,GO:0017038,GO:0031967,GO:0031975,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045036,GO:0045037,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072594,GO:0072596,GO:0072598 - - - - - - - - - - AAA,DUF825 k59_135246_1 177437.HRM2_p00720 1.69e-133 381.0 COG1708@1|root,COG1708@2|Bacteria,1NR33@1224|Proteobacteria,42YDT@68525|delta/epsilon subdivisions,2WTNB@28221|Deltaproteobacteria,2MMSX@213118|Desulfobacterales 28221|Deltaproteobacteria S nucleotidyltransferase activity - - - ko:K18236 - - - - ko00000,ko01504 - - - - k59_886196_1 1122603.ATVI01000006_gene503 4.23e-96 293.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1X3US@135614|Xanthomonadales 135614|Xanthomonadales NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_630630_2 1265313.HRUBRA_00890 3.61e-15 69.3 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_173416_1 349520.PPE_03010 2.26e-38 150.0 COG0236@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksL - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_826531_2 938288.HG326224_gene1423 2.97e-35 144.0 COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,268MU@186813|unclassified Clostridiales 186801|Clostridia J Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 k59_826531_3 1120972.AUMH01000010_gene323 1.35e-23 102.0 COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,4HA6Q@91061|Bacilli,279W3@186823|Alicyclobacillaceae 91061|Bacilli D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_826531_4 926550.CLDAP_09670 5.73e-08 58.5 COG1386@1|root,COG1386@2|Bacteria,2G6V6@200795|Chloroflexi 200795|Chloroflexi D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_826531_5 1196028.ALEF01000053_gene3536 2.57e-11 72.0 COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,4HBCE@91061|Bacilli,4C58B@84406|Virgibacillus 91061|Bacilli M Penicillin-binding protein 5, C-terminal domain dacF GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_925301_1 96561.Dole_2769 1.06e-57 192.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,2MJS3@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - - - - - - - - - - HGD-D k59_173418_1 1408473.JHXO01000006_gene1255 1.64e-113 362.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,2FNH9@200643|Bacteroidia 976|Bacteroidetes E Glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_533159_1 547045.NEISICOT_01963 9.28e-47 162.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,2KPY8@206351|Neisseriales 206351|Neisseriales F Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_533159_2 574966.KB898649_gene249 4.46e-22 95.1 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1XHFK@135619|Oceanospirillales 135619|Oceanospirillales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_695664_1 1380391.JIAS01000011_gene5357 9.08e-48 163.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2TSAD@28211|Alphaproteobacteria,2JQGB@204441|Rhodospirillales 204441|Rhodospirillales G Fructose-bisphosphate aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_695664_2 572477.Alvin_2493 3.36e-13 68.6 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1WWUS@135613|Chromatiales 135613|Chromatiales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_792121_1 240016.ABIZ01000001_gene4848 2.8e-45 158.0 COG0448@1|root,COG0448@2|Bacteria,46SG2@74201|Verrucomicrobia,2IV7B@203494|Verrucomicrobiae 203494|Verrucomicrobiae G Nucleotidyl transferase - - - - - - - - - - - - NTP_transferase k59_238194_1 1278309.KB907101_gene404 9.89e-18 80.1 COG1180@1|root,COG1180@2|Bacteria,1RA4Z@1224|Proteobacteria,1S34Q@1236|Gammaproteobacteria,1XRSI@135619|Oceanospirillales 135619|Oceanospirillales O 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_14,Radical_SAM k59_238194_2 998674.ATTE01000001_gene2458 2.75e-84 257.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,460P6@72273|Thiotrichales 72273|Thiotrichales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_467403_1 1122978.AUFP01000001_gene1145 2.03e-25 100.0 COG0503@1|root,COG0503@2|Bacteria,4NP7K@976|Bacteroidetes,2FPJ4@200643|Bacteroidia 976|Bacteroidetes F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_75242_1 926556.Echvi_3816 5.69e-109 328.0 COG3119@1|root,COG3119@2|Bacteria,4NFC9@976|Bacteroidetes,47KWC@768503|Cytophagia 976|Bacteroidetes P Domain of unknown function - - - - - - - - - - - - DUF4994,Sulfatase k59_108115_1 1221522.B723_20230 6.62e-30 120.0 COG2173@1|root,COG3786@1|root,COG2173@2|Bacteria,COG3786@2|Bacteria,1RENK@1224|Proteobacteria,1S3SJ@1236|Gammaproteobacteria,1YR3J@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide ddpX GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009046,GO:0009605,GO:0009991,GO:0016787,GO:0019538,GO:0031667,GO:0042594,GO:0043170,GO:0044238,GO:0050896,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - Peptidase_M15 k59_337285_1 1165841.SULAR_05183 1.84e-83 271.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2YMV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_401332_1 1313301.AUGC01000003_gene2121 3.57e-56 186.0 COG0451@1|root,COG0451@2|Bacteria,4NEMN@976|Bacteroidetes 976|Bacteroidetes M NAD dependent epimerase dehydratase family dfrA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_401332_2 1268072.PSAB_13545 5.35e-25 102.0 COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,4HK2U@91061|Bacilli,26R66@186822|Paenibacillaceae 91061|Bacilli S Belongs to the short-chain dehydrogenases reductases (SDR) family dltE3 - - ko:K07124 - - - - ko00000 - - - adh_short k59_238203_1 1168034.FH5T_21195 4.7e-113 348.0 COG1629@1|root,COG1629@2|Bacteria,4NFFN@976|Bacteroidetes,2G3GJ@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug k59_238203_2 1121904.ARBP01000004_gene1100 1.23e-65 218.0 COG3250@1|root,COG3250@2|Bacteria,4NEDP@976|Bacteroidetes,47JV2@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - Glyco_hydro_2_N,SASA k59_760504_1 586416.GZ22_14965 4.49e-22 100.0 COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,4H9QP@91061|Bacilli 91061|Bacilli L DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_108120_1 1415778.JQMM01000001_gene335 3.09e-175 503.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains prsR - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_337291_1 525898.Sdel_1501 2.09e-220 639.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,43BP0@68525|delta/epsilon subdivisions,2YTEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LV TaqI-like C-terminal specificity domain - - - - - - - - - - - - N6_Mtase,TaqI_C k59_270034_1 387093.SUN_2365 1.48e-76 250.0 COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2YMJN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,RMMBL k59_75265_2 104623.Ser39006_04274 7.94e-27 105.0 COG3090@1|root,COG3090@2|Bacteria,1PJM9@1224|Proteobacteria,1SWRW@1236|Gammaproteobacteria,4049R@613|Serratia 1236|Gammaproteobacteria G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_727992_1 1168034.FH5T_05165 2.79e-96 293.0 COG5557@1|root,COG5557@2|Bacteria,4NE3X@976|Bacteroidetes 976|Bacteroidetes C Pfam Polysulphide reductase, NrfD nrfD - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_727992_2 1168034.FH5T_05170 7.1e-91 268.0 COG2010@1|root,COG2010@2|Bacteria,4NEX9@976|Bacteroidetes 976|Bacteroidetes C Quinol cytochrome c oxidoreductase membrane protein actD - - - - - - - - - - - DUF3341 k59_727992_3 1168034.FH5T_05175 4.15e-41 140.0 COG2010@1|root,COG2010@2|Bacteria,4NKQI@976|Bacteroidetes 976|Bacteroidetes C Cytochrome C actE - - - - - - - - - - - Cytochrome_CBB3 k59_6117_1 1168034.FH5T_13400 7.19e-111 353.0 COG2199@1|root,COG3292@1|root,COG5002@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,4NK8Q@976|Bacteroidetes,2FXT6@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_337305_1 869213.JCM21142_72908 1.73e-14 73.6 COG0768@1|root,COG0768@2|Bacteria,4NE47@976|Bacteroidetes,47JSM@768503|Cytophagia 976|Bacteroidetes M Penicillin-binding protein, dimerisation domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_337305_2 485918.Cpin_0192 2.87e-23 95.9 2AFDM@1|root,315DF@2|Bacteria,4NQ5K@976|Bacteroidetes,1ISUS@117747|Sphingobacteriia 976|Bacteroidetes S rod shape-determining protein MreD mreD - - - - - - - - - - - - k59_75269_1 667014.Thein_1717 2.66e-73 244.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_695700_1 96561.Dole_2613 7.18e-78 237.0 COG1592@1|root,COG1592@2|Bacteria,1RCBN@1224|Proteobacteria,42QSP@68525|delta/epsilon subdivisions,2WMSS@28221|Deltaproteobacteria,2MJJU@213118|Desulfobacterales 28221|Deltaproteobacteria C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_302799_1 572544.Ilyop_0311 5.44e-28 103.0 2DHPM@1|root,300HH@2|Bacteria,37CI3@32066|Fusobacteria 32066|Fusobacteria S Uncharacterized protein conserved in bacteria (DUF2325) - - - - - - - - - - - - DUF2325 k59_302799_2 1095747.HMPREF1049_1096 1.7e-44 147.0 2CD92@1|root,32RXB@2|Bacteria,37ADM@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF2023) - - - - - - - - - - - - DUF2023 k59_302799_3 457415.HMPREF1006_01020 3.1e-44 159.0 COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,3T9SI@508458|Synergistetes 508458|Synergistetes S dioxygenase class III protein subunit B - - - - - - - - - - - - AMMECR1,LigB k59_302799_4 2423.NA23_0206565 1.97e-111 344.0 COG1180@1|root,COG1180@2|Bacteria,2GC8W@200918|Thermotogae 200918|Thermotogae C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_302799_7 888055.HMPREF9015_01778 1.29e-58 194.0 COG1496@1|root,COG1496@2|Bacteria,37ACS@32066|Fusobacteria 32066|Fusobacteria S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_302799_8 1319815.HMPREF0202_01338 8.12e-50 166.0 COG3863@1|root,COG3863@2|Bacteria,3792C@32066|Fusobacteria 32066|Fusobacteria S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 k59_302799_9 572544.Ilyop_1547 1.09e-185 521.0 COG0180@1|root,COG0180@2|Bacteria,37854@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_369433_1 563040.Saut_0078 1.11e-85 267.0 COG2038@1|root,COG2038@2|Bacteria,1NZFH@1224|Proteobacteria,42NRQ@68525|delta/epsilon subdivisions,2YNQ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H phosphoribosyltransferase - - - - - - - - - - - - DBI_PRT k59_990355_2 1342301.JASD01000008_gene2483 4.69e-17 79.7 COG3788@1|root,COG3788@2|Bacteria,1RDHP@1224|Proteobacteria,2UDRD@28211|Alphaproteobacteria,3ZXT8@60136|Sulfitobacter 28211|Alphaproteobacteria S MAPEG family - - - ko:K07136 - - - - ko00000 - - - MAPEG k59_433560_1 572544.Ilyop_0838 1.69e-61 204.0 COG0285@1|root,COG0285@2|Bacteria,378AP@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_433560_3 572544.Ilyop_0840 1.3e-225 649.0 COG1493@1|root,COG1493@2|Bacteria,378H8@32066|Fusobacteria 32066|Fusobacteria H Belongs to the HPrK P family hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_433560_4 264732.Moth_0235 2.31e-71 228.0 COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,24BGW@186801|Clostridia,42F4R@68295|Thermoanaerobacterales 186801|Clostridia S Uncharacterised 5xTM membrane BCR, YitT family COG1284 - - - - - - - - - - - - DUF2179,YitT_membrane k59_433560_5 926561.KB900617_gene1870 1.76e-36 127.0 COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,24MN5@186801|Clostridia 186801|Clostridia H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_433560_6 526224.Bmur_2594 2.47e-38 139.0 COG1683@1|root,COG1683@2|Bacteria,2J8JK@203691|Spirochaetes 203691|Spirochaetes F Protein of unknown function (DUF523) - - - - - - - - - - - - DUF523 k59_433560_7 190304.FN1011 8.53e-89 275.0 COG0618@1|root,COG0618@2|Bacteria,379ED@32066|Fusobacteria 32066|Fusobacteria S domain protein - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_433560_8 572544.Ilyop_0845 2.03e-123 362.0 COG1462@1|root,COG1462@2|Bacteria,379TT@32066|Fusobacteria 32066|Fusobacteria M Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG k59_598037_1 1384054.N790_08815 6.91e-42 139.0 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,1X7QC@135614|Xanthomonadales 135614|Xanthomonadales S BolA family transcriptional regulator yciI - - ko:K09780 - - - - ko00000 - - - YCII k59_598037_2 305700.B447_05438 6.62e-16 74.7 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,2KVFB@206389|Rhodocyclales 206389|Rhodocyclales D probably involved in intracellular septation ispZ - - ko:K06190 - - - - ko00000 - - - IspA k59_891677_1 1168034.FH5T_04015 8.82e-122 389.0 COG4797@1|root,COG4797@2|Bacteria,4PKQS@976|Bacteroidetes,2FP69@200643|Bacteroidia 976|Bacteroidetes S Motility related/secretion protein sprA - - - - - - - - - - - SprA_N k59_826577_1 525898.Sdel_1232 5.8e-317 886.0 COG0666@1|root,COG5276@1|root,COG0666@2|Bacteria,COG5276@2|Bacteria,1R46A@1224|Proteobacteria 1224|Proteobacteria S LVIVD repeat - - - - - - - - - - - - Big_5,LVIVD k59_369438_1 929558.SMGD1_2737 2.98e-59 198.0 COG0810@1|root,COG0810@2|Bacteria,1PEYQ@1224|Proteobacteria,42WJI@68525|delta/epsilon subdivisions,2YQ9A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_2,TonB_C k59_369438_3 1172190.M947_01120 1.33e-13 69.7 COG2301@1|root,COG2301@2|Bacteria,1NUDQ@1224|Proteobacteria,42QUW@68525|delta/epsilon subdivisions,2YNZV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the HpcH HpaI aldolase family citE - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_956923_1 420247.Msm_1334 1.46e-05 52.4 COG0679@1|root,arCOG04756@2157|Archaea,2XU4B@28890|Euryarchaeota,23P1C@183925|Methanobacteria 183925|Methanobacteria S auxin efflux carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_401369_1 1049564.TevJSym_ar00470 8.77e-32 123.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1J4Z1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_401369_2 1249627.D779_1951 8.65e-18 82.0 COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,1S9PP@1236|Gammaproteobacteria,1WWV8@135613|Chromatiales 135613|Chromatiales L DNA polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_566136_1 547042.BACCOPRO_00267 2.21e-32 126.0 COG0482@1|root,COG0482@2|Bacteria,4NFXZ@976|Bacteroidetes,2FMZ2@200643|Bacteroidia,4AKHD@815|Bacteroidaceae 976|Bacteroidetes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_75788_1 387093.SUN_1461 6.1e-85 256.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2YN5T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the SAICAR synthetase family purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_173967_2 477974.Daud_0559 4.32e-14 73.9 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,2604F@186807|Peptococcaceae 186801|Clostridia C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_141790_1 1294273.roselon_01608 3.76e-92 281.0 COG4782@1|root,COG4782@2|Bacteria,1R573@1224|Proteobacteria,2U4A1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Alpha/beta hydrolase of unknown function (DUF900) - - - - - - - - - - - - DUF900 k59_925925_1 436717.AOLE_09380 2.62e-22 89.4 2E9X2@1|root,3342T@2|Bacteria,1NAAT@1224|Proteobacteria,1SD6Y@1236|Gammaproteobacteria,3NRWA@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_925925_2 1355368.JART01000025_gene248 2.4e-159 458.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MCR@68525|delta/epsilon subdivisions,2YNV0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EK PFAM Aminotransferase class I and II - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_925925_3 944546.ABED_1828 1.65e-133 386.0 COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,42PYD@68525|delta/epsilon subdivisions,2YN6I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K PFAM Bacterial transcription activator, effector binding domain - - - ko:K13652 - - - - ko00000,ko03000 - - - GyrI-like,HTH_18 k59_925925_5 1122212.AULO01000006_gene1788 1.82e-39 133.0 COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,1SCS4@1236|Gammaproteobacteria,1XQUG@135619|Oceanospirillales 135619|Oceanospirillales S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - - - - - - - - - - BrnT_toxin k59_206473_1 1121434.AULY01000007_gene1414 2.53e-104 331.0 COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2M8EC@213115|Desulfovibrionales 28221|Deltaproteobacteria L DEAD DEAH box helicase domain protein yprA - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C,RNase_H_2 k59_631366_1 936155.HFELIS_12670 5.41e-48 166.0 COG0438@1|root,COG0438@2|Bacteria,1MWYH@1224|Proteobacteria,42Q22@68525|delta/epsilon subdivisions 1224|Proteobacteria M PFAM Glycosyl transferase, group 1 wcaC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K13684 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_631366_2 313624.NSP_37990 7.78e-39 145.0 COG1216@1|root,COG1216@2|Bacteria,1G9WK@1117|Cyanobacteria 1117|Cyanobacteria S Glycosyl transferase family 2 - - - ko:K13683 - - - - ko00000,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_827142_1 563040.Saut_0556 1.47e-151 441.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2YR82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I AMP-binding enzyme C-terminal domain - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_925929_1 1121405.dsmv_2552 1.56e-120 357.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MHRE@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_863973_1 1168034.FH5T_02640 1.5e-128 384.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,4NETI@976|Bacteroidetes,2FP06@200643|Bacteroidia 976|Bacteroidetes H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysN GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0044237 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU k59_863973_2 1168034.FH5T_02645 9.13e-41 144.0 COG0451@1|root,COG0451@2|Bacteria,4NEKA@976|Bacteroidetes,2FMUU@200643|Bacteroidia 976|Bacteroidetes M NAD dependent epimerase dehydratase family wcfX - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_438849_1 485915.Dret_1501 4.81e-65 214.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42SM4@68525|delta/epsilon subdivisions,2WPVD@28221|Deltaproteobacteria,2MGHY@213115|Desulfovibrionales 28221|Deltaproteobacteria L Integrase core domain - - - - - - - - - - - - rve k59_538760_1 768671.ThimaDRAFT_1769 7.4e-104 326.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_701178_1 1168034.FH5T_16495 4.74e-73 225.0 COG1013@1|root,COG1013@2|Bacteria,4NDWF@976|Bacteroidetes,2FP3C@200643|Bacteroidia 976|Bacteroidetes C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain vorA - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_701178_2 1168034.FH5T_16490 3.83e-51 171.0 COG0674@1|root,COG0674@2|Bacteria,4NGYK@976|Bacteroidetes,2FM6R@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA vorB - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_274591_1 1123234.AUKI01000011_gene1046 1.03e-41 150.0 COG1169@1|root,COG1169@2|Bacteria,4NF6U@976|Bacteroidetes,1HX5V@117743|Flavobacteriia 976|Bacteroidetes HQ Isochorismate synthase entC - 5.4.4.2 ko:K02361,ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind k59_506630_1 998674.ATTE01000001_gene3683 1.58e-29 122.0 COG0419@1|root,COG1121@1|root,COG0419@2|Bacteria,COG1121@2|Bacteria 2|Bacteria P zinc-transporting ATPase activity - - - ko:K03546,ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko03400 3.A.1.15.3,3.A.1.15.5 - - AAA_23,AAA_27,ABC_tran,SbcCD_C k59_538767_1 335543.Sfum_0492 1.88e-33 133.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42NGM@68525|delta/epsilon subdivisions,2WKBQ@28221|Deltaproteobacteria,2MQAE@213462|Syntrophobacterales 28221|Deltaproteobacteria P COGs COG4771 Outer membrane receptor for ferrienterochelin and colicins - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_636412_1 215803.DB30_6302 4.01e-90 290.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2YUDT@29|Myxococcales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_766308_1 998674.ATTE01000001_gene2426 2.02e-89 272.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,45ZRA@72273|Thiotrichales 72273|Thiotrichales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_732755_1 1165841.SULAR_08100 4.32e-49 201.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind,Laminin_G_3 k59_831802_1 1121904.ARBP01000003_gene6591 1.62e-26 114.0 COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,47JF7@768503|Cytophagia 976|Bacteroidetes E PFAM amino acid permease-associated region - - - - - - - - - - - - AA_permease,AA_permease_2,AA_permease_C,PTS_EIIA_2,TrkA_C,Usp k59_766314_1 713586.KB900536_gene2613 2.18e-75 244.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_9552_2 187272.Mlg_0002 8.56e-26 105.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1WWQF@135613|Chromatiales 135613|Chromatiales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_406686_1 395493.BegalDRAFT_2911 1.79e-69 233.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,45ZWT@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_603952_1 96561.Dole_2185 1.97e-33 129.0 COG0741@1|root,COG0741@2|Bacteria,1MW2T@1224|Proteobacteria,42M1M@68525|delta/epsilon subdivisions,2WPBN@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Lytic transglycosylase catalytic mltC - - ko:K08306,ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - DUF3393,SLT,TPR_6 k59_79949_1 1165841.SULAR_00725 3.87e-43 145.0 COG0352@1|root,COG0352@2|Bacteria,1Q57E@1224|Proteobacteria,42T8S@68525|delta/epsilon subdivisions,2YPQM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Thiamine monophosphate synthase thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_112891_2 644282.Deba_2955 1.38e-66 213.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42N9E@68525|delta/epsilon subdivisions,2WJAX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - ko:K22226 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_570629_3 387093.SUN_1302 1.6e-40 150.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,43AER@68525|delta/epsilon subdivisions,2YR8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M TIGRFAM YD repeat protein - - - - - - - - - - - - RHS_repeat k59_45591_1 1168034.FH5T_11835 4.66e-14 67.0 COG1433@1|root,COG1433@2|Bacteria 2|Bacteria S nitrogen fixation VPA0323 - - - - - - - - - - - Nitro_FeMo-Co k59_45591_2 1408473.JHXO01000001_gene2447 5.96e-62 191.0 COG0599@1|root,COG0599@2|Bacteria,4NNRB@976|Bacteroidetes,2FTME@200643|Bacteroidia 976|Bacteroidetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_274622_1 1429851.X548_09300 3.39e-74 233.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1X38D@135614|Xanthomonadales 135614|Xanthomonadales M synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_179263_1 1408439.JHXW01000009_gene325 2.57e-78 243.0 COG2984@1|root,COG2984@2|Bacteria,378FN@32066|Fusobacteria 32066|Fusobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_179263_5 86416.Clopa_3496 2.58e-108 325.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36DK7@31979|Clostridiaceae 186801|Clostridia C Belongs to the aldehyde dehydrogenase family gapN - 1.2.1.9 ko:K00131 ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200 M00308,M00633 R01058 RC00242 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1027465_1 933262.AXAM01000084_gene1047 7.08e-90 280.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2MISA@213118|Desulfobacterales 28221|Deltaproteobacteria H Belongs to the precorrin methyltransferase family hemD - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,TP_methylase k59_308185_1 387092.NIS_0049 1.94e-25 98.2 2B5BG@1|root,31Y5N@2|Bacteria,1RJ1N@1224|Proteobacteria,42TPY@68525|delta/epsilon subdivisions,2YPZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_308185_2 387093.SUN_0073 1.76e-31 119.0 COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,42P5E@68525|delta/epsilon subdivisions,2YN01@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Fad-dependent pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_732787_1 1537917.JU82_01110 6.68e-49 159.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,42RJX@68525|delta/epsilon subdivisions,2YP8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_732787_3 1249480.B649_05605 1.93e-54 176.0 COG2932@1|root,COG2932@2|Bacteria,1RIP6@1224|Proteobacteria,42RJG@68525|delta/epsilon subdivisions,2YP8P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K phage repressor - - - - - - - - - - - - Peptidase_S24,Phage_CI_repr k59_930742_1 402881.Plav_3501 2.3e-18 83.6 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,1JN9Q@119043|Rhodobiaceae 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_930742_2 596323.HMPREF0554_1128 4.64e-142 417.0 COG0460@1|root,COG0460@2|Bacteria,378Z0@32066|Fusobacteria 32066|Fusobacteria E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - Homoserine_dh,NAD_binding_3 k59_539476_7 987059.RBXJA2T_16992 1.13e-135 404.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQS@28216|Betaproteobacteria,1KKIN@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K06714 - - - - ko00000,ko03000 - - - HTH_8,PAS_4,Sigma54_activat k59_539476_9 1430440.MGMSRv2_1032 5.66e-154 447.0 COG5424@1|root,COG5424@2|Bacteria,1NM66@1224|Proteobacteria,2UR4P@28211|Alphaproteobacteria,2JV56@204441|Rhodospirillales 204441|Rhodospirillales H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ - - - - - - - - - - - - - k59_539476_10 1307436.PBF_10352 1.68e-35 139.0 COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,4H9KQ@91061|Bacilli,1ZBZ1@1386|Bacillus 91061|Bacilli E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0004425,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_539476_11 1202962.KB907189_gene2892 1.45e-222 708.0 COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S0EK@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Calx-beta,HemolysinCabind,Peptidase_M10,Peptidase_M10_C,VWA_2 k59_472539_1 1122201.AUAZ01000019_gene1755 6.07e-96 293.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,464HF@72275|Alteromonadaceae 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_275314_1 1117943.SFHH103_02103 1.49e-42 155.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2UPB5@28211|Alphaproteobacteria,4B874@82115|Rhizobiaceae 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD2 - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_571390_1 232721.Ajs_4011 1.59e-17 89.0 COG4733@1|root,COG4733@2|Bacteria,1QXJ9@1224|Proteobacteria,2WH5G@28216|Betaproteobacteria,4AEUA@80864|Comamonadaceae 28216|Betaproteobacteria S cellulase activity - - - - - - - - - - - - - k59_571392_1 565033.GACE_0133 6.22e-22 100.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,246RE@183980|Archaeoglobi 183980|Archaeoglobi C acetyl coenzyme A synthetase - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_46297_1 76114.ebA573 7.02e-16 77.8 COG3039@1|root,COG3039@2|Bacteria,1R64B@1224|Proteobacteria,2W09R@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_439561_1 1537915.JU57_05520 2.11e-59 207.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2YMBT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L ATP-dependent DNA helicase recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_439561_2 1537917.JU82_03755 7.49e-155 450.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2YMI1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Peptidase, M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_701938_1 1348635.BBJY01000020_gene2770 5.09e-104 316.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1XSEX@135623|Vibrionales 135623|Vibrionales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_571394_1 1492737.FEM08_05240 1.41e-12 73.2 COG1361@1|root,COG2304@1|root,COG2374@1|root,COG3209@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG2374@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ7S@117743|Flavobacteriia,2P0VG@237|Flavobacterium 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,Calx-beta,DUF11,HYR,SprB k59_963263_1 96561.Dole_1584 2.37e-114 339.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MI24@213118|Desulfobacterales 28221|Deltaproteobacteria E aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_571395_1 1110502.TMO_1605 1.11e-91 285.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,2JQE2@204441|Rhodospirillales 204441|Rhodospirillales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_963264_1 266265.Bxe_C0490 5.59e-28 110.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase IS116/IS110/IS902 family - - - ko:K07486 - - - - ko00000 - - - Transposase_20 k59_343719_1 690850.Desaf_2802 3.99e-75 241.0 COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2M8S3@213115|Desulfovibrionales 28221|Deltaproteobacteria J PFAM RNA binding S1 domain protein - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_179993_1 1235798.C817_03693 2.65e-40 150.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia,27WAS@189330|Dorea 186801|Clostridia S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_147468_2 1565314.OA34_08980 1.55e-125 366.0 COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,42NK6@68525|delta/epsilon subdivisions,2YMCE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_147471_1 13333.ERN02869 5.84e-38 130.0 2CHYC@1|root,2S3QA@2759|Eukaryota,37V66@33090|Viridiplantae,3GJP6@35493|Streptophyta 35493|Streptophyta C This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation psbE - - ko:K02707,ko:K02713 ko00195,ko01100,map00195,map01100 M00161 - - ko00000,ko00001,ko00002,ko00194 - - - Cytochrom_B559,Cytochrom_B559a,PsbL k59_864715_1 317025.Tcr_1150 1.22e-58 207.0 COG2202@1|root,COG2203@1|root,COG5001@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,45ZZR@72273|Thiotrichales 72273|Thiotrichales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_9 k59_275325_1 1004149.AFOE01000007_gene1464 4.07e-07 55.1 COG0521@1|root,COG0521@2|Bacteria,4PKAT@976|Bacteroidetes,1IKAW@117743|Flavobacteriia 976|Bacteroidetes H Starch-binding associating with outer membrane - - - - - - - - - - - - SusD-like_2 k59_180005_1 1537917.JU82_04795 2.5e-159 473.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2YMIZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_507306_1 1120966.AUBU01000016_gene3070 1.68e-20 96.7 COG1361@1|root,COG2911@1|root,COG1361@2|Bacteria,COG2911@2|Bacteria,4PPBJ@976|Bacteroidetes,47TYA@768503|Cytophagia 976|Bacteroidetes M Conserved repeat domain - - - - - - - - - - - - - k59_931305_1 1267535.KB906767_gene1214 1.03e-104 322.0 COG2433@1|root,COG2433@2|Bacteria,3Y7F1@57723|Acidobacteria 57723|Acidobacteria S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_1028186_1 862908.BMS_2145 1.43e-29 121.0 COG2103@1|root,COG2103@2|Bacteria,1Q58C@1224|Proteobacteria,430SB@68525|delta/epsilon subdivisions,2WW60@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate - - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - - k59_10286_1 469615.FGAG_00529 2.98e-97 303.0 COG0596@1|root,COG0596@2|Bacteria,37966@32066|Fusobacteria 32066|Fusobacteria S Alpha beta hydrolase - - - - - - - - - - - - - k59_733436_1 1410653.JHVC01000014_gene3330 3.4e-39 142.0 2DMBE@1|root,32GQM@2|Bacteria,1VAR6@1239|Firmicutes,24JCR@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_963282_1 387093.SUN_1738 5.77e-45 152.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,42NNW@68525|delta/epsilon subdivisions,2YN9Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM ABC transporter kpsT - 3.6.3.38 ko:K09689 ko02010,map02010 M00249 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.101 - - ABC_tran k59_963282_2 349965.yinte0001_9540 8.24e-51 183.0 COG3524@1|root,COG3524@2|Bacteria,1R3ZY@1224|Proteobacteria,1RPZH@1236|Gammaproteobacteria,41GXV@629|Yersinia 1236|Gammaproteobacteria M COG3524 Capsule polysaccharide export protein kpsE - - ko:K10107 ko02010,map02010 M00249 - - ko00000,ko00001,ko00002,ko02000 3.A.1.101 - - - k59_963284_1 2340.JV46_14410 2.37e-109 346.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_147482_2 1220534.B655_0412 9.51e-34 120.0 COG1917@1|root,arCOG02992@2157|Archaea,2XZHW@28890|Euryarchaeota 28890|Euryarchaeota G PFAM Cupin - - - - - - - - - - - - Cupin_2 k59_931312_1 1270193.JARP01000002_gene648 2.22e-85 268.0 COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,1HX8I@117743|Flavobacteriia,2NV6I@237|Flavobacterium 976|Bacteroidetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_539515_1 1121904.ARBP01000002_gene6850 8.23e-136 410.0 COG1434@1|root,COG1470@1|root,COG1434@2|Bacteria,COG1470@2|Bacteria,4NE96@976|Bacteroidetes,47KG6@768503|Cytophagia 976|Bacteroidetes S Gram-negative-bacterium-type cell wall biogenesis - - - - - - - - - - - - NPCBM k59_275343_1 1168034.FH5T_02050 4.04e-07 50.4 COG0492@1|root,COG0492@2|Bacteria,4NEVX@976|Bacteroidetes,2FMNF@200643|Bacteroidia 976|Bacteroidetes C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_275343_2 1408310.JHUW01000011_gene2010 2.78e-48 171.0 COG1070@1|root,COG1070@2|Bacteria,4NIJC@976|Bacteroidetes,2FP4C@200643|Bacteroidia 976|Bacteroidetes G Carbohydrate kinase, FGGY family protein rhaB GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 2.7.1.5,2.7.1.51 ko:K00848,ko:K00879 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01902,R03014,R03241 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_604653_1 1121104.AQXH01000005_gene174 1.31e-39 151.0 COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes,1IQM5@117747|Sphingobacteriia 976|Bacteroidetes E Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 k59_275355_1 1437606.BBOH_1215 7.19e-09 57.4 COG0454@1|root,COG0456@2|Bacteria,2I718@201174|Actinobacteria,4D2YW@85004|Bifidobacteriales 201174|Actinobacteria K Acetyltransferase (GNAT) family - - 2.3.1.57 ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_275355_2 448385.sce2244 3.24e-47 157.0 COG1247@1|root,COG1247@2|Bacteria,1QW9G@1224|Proteobacteria,43CUJ@68525|delta/epsilon subdivisions,2WY2V@28221|Deltaproteobacteria,2Z2KE@29|Myxococcales 28221|Deltaproteobacteria M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 k59_767188_1 1249480.B649_03430 5.03e-64 204.0 COG0847@1|root,COG0847@2|Bacteria,1RGGD@1224|Proteobacteria,42ZIP@68525|delta/epsilon subdivisions,2YRQP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0847 DNA polymerase III epsilon subunit and related 3'-5' - - 2.7.7.7 ko:K02342,ko:K10857 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_767188_2 326298.Suden_0557 6.25e-56 178.0 2A067@1|root,30N97@2|Bacteria,1Q1X8@1224|Proteobacteria,42UM9@68525|delta/epsilon subdivisions,2YPYZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_539527_1 933262.AXAM01000008_gene1932 4.95e-18 84.3 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2MIIC@213118|Desulfobacterales 28221|Deltaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA k59_407461_1 1131451.O1K_15606 3.68e-82 271.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales 135614|Xanthomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_604662_1 1255043.TVNIR_1947 1.22e-08 55.1 COG0839@1|root,COG0839@2|Bacteria 2|Bacteria C Belongs to the complex I subunit 6 family nuoJ-1 - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_968765_2 1537917.JU82_10780 1.13e-112 327.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,42R4H@68525|delta/epsilon subdivisions,2YNWA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0321 Guanylate_kin k59_739273_1 1168034.FH5T_12220 9.03e-124 360.0 COG1932@1|root,COG1932@2|Bacteria,4NE06@976|Bacteroidetes,2FMET@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_643112_1 221988.MS1169 3.19e-101 318.0 COG2831@1|root,COG2831@2|Bacteria,1MXF6@1224|Proteobacteria,1RQJB@1236|Gammaproteobacteria,1Y6TM@135625|Pasteurellales 135625|Pasteurellales U Hemolysin activation secretion protein - - - - - - - - - - - - POTRA_2,POTRA_3,ShlB k59_250127_1 1245471.PCA10_40500 7.58e-42 148.0 COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,1S8SQ@1236|Gammaproteobacteria,1YFFT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria N Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly flgA - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA k59_870704_2 1249480.B649_01495 1.36e-96 295.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2YMV0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_643115_1 1121403.AUCV01000001_gene690 1.74e-70 237.0 COG2204@1|root,COG4191@1|root,COG4564@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,COG4564@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria,2MIG9@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_577571_1 1168034.FH5T_09855 5.93e-121 354.0 COG0482@1|root,COG0482@2|Bacteria,4NFXZ@976|Bacteroidetes,2FPBU@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_969491_1 1116472.MGMO_17c00180 5.18e-221 637.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1XDY0@135618|Methylococcales 135618|Methylococcales G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_314807_1 177437.HRM2_10830 1.53e-90 288.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_119965_1 1041159.AZUW01000029_gene690 1.33e-35 135.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2TS9C@28211|Alphaproteobacteria,4BACH@82115|Rhizobiaceae 28211|Alphaproteobacteria E Aminotransferase tatA - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_870722_1 1357400.HMPREF2086_00430 4.3e-22 99.4 COG4733@1|root,COG4733@2|Bacteria,1N010@1224|Proteobacteria,42M7U@68525|delta/epsilon subdivisions,2YM7Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Fibronectin type 3 domain-containing protein - - - ko:K06882 - - - - ko00000 - - - fn3 k59_445689_1 522772.Dacet_0306 2.23e-72 227.0 COG0619@1|root,COG0619@2|Bacteria,2GG68@200930|Deferribacteres 200930|Deferribacteres P cobalt ABC transporter, inner membrane subunit CbiQ - - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ k59_445689_2 316067.Geob_3337 7.09e-15 72.4 COG1122@1|root,COG1122@2|Bacteria,1N5X0@1224|Proteobacteria,43ADF@68525|delta/epsilon subdivisions,2WMEV@28221|Deltaproteobacteria,43T54@69541|Desulfuromonadales 28221|Deltaproteobacteria P part of an ABC transporter complex. Responsible for energy coupling to the transport system - - - ko:K02006,ko:K16787 ko02010,map02010 M00245,M00246,M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k59_969508_1 1123257.AUFV01000002_gene2377 3.61e-11 63.5 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1X811@135614|Xanthomonadales 135614|Xanthomonadales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_969508_2 1123256.KB907938_gene561 5.12e-41 150.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1X50J@135614|Xanthomonadales 135614|Xanthomonadales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_513381_1 1168034.FH5T_06485 1.55e-105 331.0 COG3291@1|root,COG4447@1|root,COG3291@2|Bacteria,COG4447@2|Bacteria,4NGJJ@976|Bacteroidetes,2FRXF@200643|Bacteroidia 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - - k59_86823_2 1168034.FH5T_09735 2.19e-74 228.0 COG2836@1|root,COG2836@2|Bacteria,4NF84@976|Bacteroidetes 976|Bacteroidetes S cytochrome c biogenesis protein - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_381214_1 644282.Deba_1038 4.94e-53 184.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2WIIT@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Pyruvate flavodoxin ferredoxin oxidoreductase domain protein porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_250151_1 909663.KI867150_gene971 1.09e-90 281.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X1VS@28221|Deltaproteobacteria,2MRES@213462|Syntrophobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_969515_1 1403313.AXBR01000003_gene4034 1.33e-30 124.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,1ZEFV@1386|Bacillus 91061|Bacilli O Subtilase family - - 3.4.21.66 ko:K08651 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_250154_1 998088.B565_0934 1.75e-67 211.0 COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,1S3R3@1236|Gammaproteobacteria,1Y540@135624|Aeromonadales 135624|Aeromonadales NU COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_19,TPR_8 k59_478601_2 1182553.XP_007746923.1 1.97e-13 73.2 COG1104@1|root,KOG1549@2759|Eukaryota,39V6W@33154|Opisthokonta,3NWXZ@4751|Fungi,3QMGP@4890|Ascomycota,20FCR@147545|Eurotiomycetes,3MV7V@451870|Chaetothyriomycetidae 4751|Fungi E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_153457_1 582744.Msip34_0657 1.33e-111 343.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,2KKFS@206350|Nitrosomonadales 206350|Nitrosomonadales C pyridine nucleotide-disulphide oxidoreductase dimerisation - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_676546_1 472759.Nhal_2749 4.6e-74 228.0 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1WY08@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_676546_2 225849.swp_2371 3.41e-17 77.4 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,2QA33@267890|Shewanellaceae 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944 - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_186094_1 1202962.KB907180_gene167 9.51e-14 72.8 COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,1RNZC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Gram-negative-bacterium-type cell wall biogenesis ycbC GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564 - - - - - - - - - - DUF218 k59_643171_1 1437448.AZRT01000082_gene3883 2.43e-16 78.6 COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,2TSJ4@28211|Alphaproteobacteria,1J1TG@118882|Brucellaceae 28211|Alphaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_86841_1 1163617.SCD_n02239 2.27e-71 236.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_513405_1 1046627.BZARG_2509 7.56e-12 67.4 COG1225@1|root,COG1225@2|Bacteria,4NH32@976|Bacteroidetes,1HWQJ@117743|Flavobacteriia 976|Bacteroidetes O Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,Thioredoxin_8 k59_513405_2 1223410.KN050846_gene159 9.22e-17 78.6 COG0488@1|root,COG0488@2|Bacteria,4NEHU@976|Bacteroidetes,1HXV7@117743|Flavobacteriia 976|Bacteroidetes S abc transporter (atp-binding protein) - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_739347_1 1172188.KB911820_gene2842 1.05e-83 263.0 28MN1@1|root,2ZAXN@2|Bacteria,2H2TF@201174|Actinobacteria 201174|Actinobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6C k59_186104_1 765911.Thivi_0734 1.76e-53 177.0 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria,1WXBJ@135613|Chromatiales 135613|Chromatiales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_120027_1 290317.Cpha266_0765 2.85e-98 304.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria 2|Bacteria C pentaerythritol trinitrate reductase activity - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_870763_2 1158150.KB906248_gene2269 2.5e-19 82.8 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZF3@135613|Chromatiales 135613|Chromatiales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_870763_3 1500893.JQNB01000001_gene1310 0.0002 41.2 2C0ET@1|root,33A9M@2|Bacteria,1NGE5@1224|Proteobacteria,1SGID@1236|Gammaproteobacteria,1X83G@135614|Xanthomonadales 135614|Xanthomonadales S TIGRFAM TIGR02449 family protein VL23_04670 - - ko:K09892 - - - - ko00000,ko03036 - - - ZapB k59_513415_2 1218084.BBJK01000149_gene7525 2.04e-140 409.0 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WB1W@28216|Betaproteobacteria,1K4YH@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_1002690_1 1122201.AUAZ01000025_gene3559 2.64e-14 73.9 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RYX7@1236|Gammaproteobacteria,46ASD@72275|Alteromonadaceae 1236|Gammaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve k59_1002690_2 666685.R2APBS1_2749 1.92e-52 167.0 COG2963@1|root,COG2963@2|Bacteria,1N1CG@1224|Proteobacteria,1SAIC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_708048_1 257313.BP1263 2.42e-48 157.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,3T488@506|Alcaligenaceae 28216|Betaproteobacteria O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_708048_2 1238190.AMQY01000023_gene327 4.99e-37 137.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1XHZA@135619|Oceanospirillales 135619|Oceanospirillales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_643196_1 1387312.BAUS01000004_gene1785 5.54e-55 185.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,2KKR5@206350|Nitrosomonadales 206350|Nitrosomonadales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_643196_2 396588.Tgr7_2141 5.8e-28 106.0 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1WYQ1@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, chi subunit - - 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_16578_1 768671.ThimaDRAFT_0705 2.07e-79 256.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_445734_1 1000588.HMPREF9965_0454 4.76e-36 139.0 COG1106@1|root,COG1106@2|Bacteria,1V0QA@1239|Firmicutes 1239|Firmicutes S AAA ATPase domain - - - - - - - - - - - - AAA_15 k59_513420_1 866895.HBHAL_4535 6.58e-177 504.0 COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,4HARP@91061|Bacilli,3NDTW@45667|Halobacillus 91061|Bacilli G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) galK GO:0005975,GO:0005996,GO:0006012,GO:0008150,GO:0008152,GO:0019318,GO:0044238,GO:0044281,GO:0071704 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_513423_1 1123236.KB899377_gene357 3.53e-155 450.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,465WS@72275|Alteromonadaceae 1236|Gammaproteobacteria E Gamma-glutamyltranspeptidase ggt_2 - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_186122_1 1168034.FH5T_04685 1.97e-104 335.0 COG5000@1|root,COG5000@2|Bacteria,4NE49@976|Bacteroidetes,2FRVJ@200643|Bacteroidia 976|Bacteroidetes T COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation zraS_1 - - - - - - - - - - - HATPase_c,HisKA k59_349788_1 1122223.KB890687_gene2619 1.18e-64 215.0 COG0675@1|root,COG0675@2|Bacteria,1WJ2V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L Probable transposase - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_513430_1 123214.PERMA_1571 1.28e-39 145.0 COG3203@1|root,COG3203@2|Bacteria,2G42A@200783|Aquificae 200783|Aquificae M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_218505_1 572544.Ilyop_0476 3.26e-104 313.0 COG1929@1|root,COG1929@2|Bacteria,379HN@32066|Fusobacteria 32066|Fusobacteria G Belongs to the glycerate kinase type-1 family - - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase k59_643215_1 264201.pc1324 5.66e-141 415.0 COG0442@1|root,COG0442@2|Bacteria,2JFHZ@204428|Chlamydiae 204428|Chlamydiae J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_314910_1 1168034.FH5T_07420 3.5e-26 102.0 COG1496@1|root,COG1496@2|Bacteria,4NM9H@976|Bacteroidetes,2FN7X@200643|Bacteroidia 976|Bacteroidetes S Belongs to the multicopper oxidase YfiH RL5 family - GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_349793_1 572480.Arnit_2394 4.65e-10 61.6 COG4238@1|root,COG4238@2|Bacteria,1N4E5@1224|Proteobacteria,42USX@68525|delta/epsilon subdivisions,2YQ09@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M major outer membrane lipoprotein - - - - - - - - - - - - - k59_349793_2 367737.Abu_1234 2.71e-05 45.4 2AK35@1|root,31ASX@2|Bacteria,1Q62J@1224|Proteobacteria,42W2T@68525|delta/epsilon subdivisions,2YQDE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_52330_1 1120953.AUBH01000001_gene1198 9e-68 224.0 COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria,464Q7@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.135 ko:K21575 - - - - ko00000,ko01000 - GH13 - Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N k59_218523_1 502025.Hoch_0835 2.22e-55 188.0 2EREN@1|root,33J06@2|Bacteria,1Q57T@1224|Proteobacteria,43A4Y@68525|delta/epsilon subdivisions,2X9T2@28221|Deltaproteobacteria,2YY32@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_16614_1 870187.Thini_0860 2.98e-85 259.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,4603R@72273|Thiotrichales 72273|Thiotrichales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_445773_1 1304885.AUEY01000133_gene1484 4.92e-63 215.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,2MHKM@213118|Desulfobacterales 28221|Deltaproteobacteria L TIGRFAM ATP-dependent DNA helicase, RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind,UvrD-helicase,UvrD_C k59_413353_1 1211114.ALIP01000132_gene2048 1.7e-114 364.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1X465@135614|Xanthomonadales 135614|Xanthomonadales E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_381276_1 1163409.UUA_11863 5.35e-78 247.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1X31X@135614|Xanthomonadales 135614|Xanthomonadales C Electron transfer flavoprotein-ubiquinone oxidoreductase etf-QO - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 k59_381276_2 281687.CJA12370b 2.62e-05 45.4 COG2086@1|root,KOG3180@2759|Eukaryota,38DVE@33154|Opisthokonta,3BCQ1@33208|Metazoa,3CW63@33213|Bilateria,40BTF@6231|Nematoda,1KV3W@119089|Chromadorea,40UMK@6236|Rhabditida 33208|Metazoa C Electron transfer flavoprotein domain ETFB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007399,GO:0007406,GO:0008150,GO:0008152,GO:0008285,GO:0009055,GO:0009056,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010721,GO:0016042,GO:0016054,GO:0016310,GO:0016491,GO:0017133,GO:0017144,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0022008,GO:0022900,GO:0030154,GO:0030258,GO:0031974,GO:0032501,GO:0032502,GO:0032787,GO:0032991,GO:0033539,GO:0034440,GO:0034641,GO:0042127,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045251,GO:0045595,GO:0045596,GO:0046034,GO:0046395,GO:0046483,GO:0048519,GO:0048523,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051239,GO:0051241,GO:0051960,GO:0051961,GO:0055086,GO:0055114,GO:0060284,GO:0065007,GO:0070013,GO:0071704,GO:0072091,GO:0072329,GO:0072521,GO:0098798,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1902494,GO:1902692,GO:1990204,GO:2000026,GO:2000177,GO:2000178,GO:2000647 - ko:K03521 - - - - ko00000 - - - ETF k59_643231_1 765912.Thimo_3481 2.69e-88 287.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWSZ@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_739414_1 765911.Thivi_3114 3.07e-138 402.0 COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,1RYIC@1236|Gammaproteobacteria,1WY81@135613|Chromatiales 135613|Chromatiales C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388,ko:K16885 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored k59_577659_1 105559.Nwat_1031 1.11e-75 233.0 COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,1WYZ2@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL k59_610569_1 585543.HMPREF0969_02169 3.6e-71 240.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,2FWS8@200643|Bacteroidia,4AWF7@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_120103_1 765912.Thimo_2592 2.52e-65 222.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales 135613|Chromatiales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_838684_1 2340.JV46_17590 2.96e-49 160.0 2BE3G@1|root,327U6@2|Bacteria,1RI7X@1224|Proteobacteria,1S88B@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_577661_1 396588.Tgr7_1531 2.72e-59 198.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales 135613|Chromatiales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_774026_2 1434325.AZQN01000004_gene1613 5.95e-61 195.0 COG1082@1|root,COG1082@2|Bacteria,4NGKX@976|Bacteroidetes,47N5C@768503|Cytophagia 976|Bacteroidetes G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_120718_1 267377.MMP0797 6.95e-35 132.0 COG0477@1|root,arCOG00130@2157|Archaea 2157|Archaea EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1034664_1 383372.Rcas_3934 8.28e-06 46.6 COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi,37599@32061|Chloroflexia 32061|Chloroflexia I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1034664_2 378806.STAUR_0177 3.6e-108 321.0 COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,42ND0@68525|delta/epsilon subdivisions,2WNKU@28221|Deltaproteobacteria,2YTTK@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF808) - - - ko:K09781 - - - - ko00000 - - - DUF808 k59_970308_1 754476.Q7A_747 6.47e-71 228.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,46060@72273|Thiotrichales 72273|Thiotrichales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_282025_1 391009.Tmel_0548 1.31e-151 449.0 COG1523@1|root,COG1523@2|Bacteria,2GC11@200918|Thermotogae 200918|Thermotogae G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1003429_1 1168034.FH5T_16880 7.34e-30 117.0 COG1480@1|root,COG1480@2|Bacteria,4NEHV@976|Bacteroidetes,2FNT9@200643|Bacteroidia 976|Bacteroidetes S 7TM receptor with intracellular HD hydrolase - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_1003429_2 1168034.FH5T_16885 4.28e-35 125.0 COG0791@1|root,COG0791@2|Bacteria,4NE2T@976|Bacteroidetes,2FMNQ@200643|Bacteroidia 976|Bacteroidetes M NlpC P60 family ykfC - - - - - - - - - - - NLPC_P60,SH3_3 k59_219265_1 1385515.N791_13080 4.52e-32 123.0 COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1X3K5@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the MtfA family - - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90 k59_250950_1 111780.Sta7437_1577 5.89e-35 127.0 COG1943@1|root,COG1943@2|Bacteria,1G79U@1117|Cyanobacteria,3VK18@52604|Pleurocapsales 1117|Cyanobacteria L PFAM Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_350466_1 56780.SYN_00496 6e-277 785.0 COG1196@1|root,COG1196@2|Bacteria,1QV9R@1224|Proteobacteria 1224|Proteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_22993_2 991905.SL003B_0895 1.89e-36 129.0 COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,4BQ5D@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1013) MA20_20925 - - ko:K09987 - - - - ko00000 - - - DUF1013 k59_126140_1 391615.ABSJ01000017_gene1628 1.4e-168 490.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1J571@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345 SBP_bac_3,SLT k59_126140_2 765911.Thivi_2275 8.34e-62 198.0 COG0590@1|root,COG2154@1|root,COG0590@2|Bacteria,COG2154@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1WXZ8@135613|Chromatiales 135613|Chromatiales FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k59_126140_4 1353529.M899_0884 7.26e-86 264.0 COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,42UTP@68525|delta/epsilon subdivisions,2MU92@213481|Bdellovibrionales,2WQM6@28221|Deltaproteobacteria 213481|Bdellovibrionales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_126140_5 1201288.M900_0249 2.15e-178 513.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,42N65@68525|delta/epsilon subdivisions,2MTGR@213481|Bdellovibrionales,2WJ98@28221|Deltaproteobacteria 213481|Bdellovibrionales C belongs to the aldehyde dehydrogenase family aldH - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_126140_6 667632.KB890165_gene2619 1.06e-140 412.0 COG1879@1|root,COG1879@2|Bacteria,1MUJU@1224|Proteobacteria,2VJED@28216|Betaproteobacteria,1K4RC@119060|Burkholderiaceae 28216|Betaproteobacteria G Periplasmic binding protein domain - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_126140_7 373994.Riv7116_6047 9.05e-35 147.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1G4CY@1117|Cyanobacteria,1HTVS@1161|Nostocales 1117|Cyanobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_9 k59_126140_8 640081.Dsui_0442 3.61e-90 272.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,2KUYM@206389|Rhodocyclales 206389|Rhodocyclales M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_126140_9 1120956.JHZK01000019_gene2488 1.1e-228 647.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,2TR5T@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_126140_10 1249627.D779_3788 2.99e-72 226.0 COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,1S54N@1236|Gammaproteobacteria,1WVV7@135613|Chromatiales 135613|Chromatiales C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) - - - - - - - - - - - - Ni_hydr_CYTB k59_126140_11 313628.LNTAR_20558 1.27e-31 123.0 2E56D@1|root,32ZZ3@2|Bacteria 2|Bacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_126140_12 1049564.TevJSym_af00200 0.0 893.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1J4G5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 GATase,GMP_synt_C,NAD_synthase k59_126140_13 1049564.TevJSym_af00210 1.29e-280 776.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1J4NW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO k59_126140_14 1049564.TevJSym_af00230 5.45e-138 412.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1J4IC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_126140_15 1049564.TevJSym_bw00080 1.52e-258 717.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1J5FV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase gdhA - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_126140_16 314292.VAS14_14659 2.47e-69 213.0 2DZY4@1|root,32VMX@2|Bacteria,1QEQ9@1224|Proteobacteria,1TBIE@1236|Gammaproteobacteria,1Y12C@135623|Vibrionales 135623|Vibrionales S Family of unknown function (DUF695) - - - - - - - - - - - - DUF695 k59_126140_17 1396858.Q666_02815 1.57e-72 220.0 COG0454@1|root,COG0456@2|Bacteria,1RGV2@1224|Proteobacteria,1S8FN@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_126140_18 1123514.KB905899_gene479 2.08e-95 283.0 COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,1S99C@1236|Gammaproteobacteria,463J4@72273|Thiotrichales 72273|Thiotrichales S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_126140_20 1049564.TevJSym_ac01890 5.94e-233 652.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1J4NG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_126140_21 697282.Mettu_2701 9.5e-77 250.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1XE8E@135618|Methylococcales 135618|Methylococcales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_126140_22 1120953.AUBH01000017_gene2886 2.66e-14 76.3 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,467Y0@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_126140_23 1049564.TevJSym_ac01920 6.7e-226 632.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1J4C1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J histidyl-tRNA synthetase hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His k59_126140_24 1123392.AQWL01000004_gene2702 5.92e-09 64.7 COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,2VVFV@28216|Betaproteobacteria,1KSP5@119069|Hydrogenophilales 119069|Hydrogenophilales S Helix-turn-helix domain - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_126140_25 396588.Tgr7_2050 4.68e-31 123.0 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1WWUQ@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus biogenesis stability protein PilW - - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - LysM,TPR_10,TPR_14,TPR_16,TPR_17,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_126140_26 1049564.TevJSym_ac01950 8.19e-193 543.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1J4M5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_126140_27 1049564.TevJSym_ac01970 9.2e-281 794.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J4XS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_2673 ACT_4,HD_4,RelA_SpoT,TGS k59_126140_28 765912.Thimo_3042 0.0 934.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1WW6M@135613|Chromatiales 135613|Chromatiales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_126140_29 1249627.D779_3451 4.58e-297 822.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1WXSP@135613|Chromatiales 135613|Chromatiales G alpha beta alpha domain I - - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_126140_31 1121935.AQXX01000113_gene1400 2.17e-92 290.0 COG3152@1|root,COG3152@2|Bacteria,1NX3I@1224|Proteobacteria,1SP6B@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - - k59_126140_32 1122599.AUGR01000010_gene1087 2.34e-47 157.0 COG1652@1|root,COG1652@2|Bacteria,1RD8K@1224|Proteobacteria,1S4CB@1236|Gammaproteobacteria,1XPHR@135619|Oceanospirillales 135619|Oceanospirillales S BON domain - - - - - - - - - - - - BON,LysM k59_126140_33 762903.Pedsa_1506 3.34e-14 67.4 COG3360@1|root,COG3360@2|Bacteria,4NURJ@976|Bacteroidetes,1IU3M@117747|Sphingobacteriia 976|Bacteroidetes S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_126140_34 1121948.AUAC01000002_gene1127 9.59e-41 144.0 COG5403@1|root,COG5403@2|Bacteria,1N0H4@1224|Proteobacteria,2UFMN@28211|Alphaproteobacteria,43XNE@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF937) - - - - - - - - - - - - DUF937 k59_126140_35 324925.Ppha_0925 8.39e-193 551.0 COG1236@1|root,COG1236@2|Bacteria,1FER3@1090|Chlorobi 1090|Chlorobi J PFAM beta-lactamase domain protein - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_126140_36 1049564.TevJSym_ab00250 7.92e-227 637.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_126140_37 765912.Thimo_2007 0.0 972.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_126140_38 1245469.S58_51320 1.55e-99 306.0 COG0348@1|root,COG0348@2|Bacteria,1R8G0@1224|Proteobacteria,2U46K@28211|Alphaproteobacteria,3JX79@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - - k59_126140_39 1232683.ADIMK_0819 2.87e-143 422.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RQCR@1236|Gammaproteobacteria,46686@72275|Alteromonadaceae 1236|Gammaproteobacteria T periplasmic ligand-binding sensor domain - - - - - - - - - - - - GGDEF,Reg_prop,Y_Y_Y k59_126140_40 1123519.PSJM300_16300 2.48e-139 431.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1Z2CU@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CZB,HAMP,MCPsignal,dCache_3 k59_126140_41 765911.Thivi_2079 3.46e-248 692.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_126140_42 887898.HMPREF0551_0546 1.13e-64 204.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,1KGR6@119060|Burkholderiaceae 28216|Betaproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_257170_1 572544.Ilyop_1165 6.6e-100 297.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport - - - - - - - - - - - - MS_channel k59_809162_1 177437.HRM2_p00180 3.18e-144 424.0 COG4584@1|root,COG4584@2|Bacteria 2|Bacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_38,HTH_7,rve k59_809162_2 177437.HRM2_p00190 2.69e-83 260.0 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_650001_1 1120705.FG95_02911 1.47e-55 191.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales 204457|Sphingomonadales L Integrase core domain - - - - - - - - - - - - rve k59_584820_1 1499680.CCFE01000018_gene1635 3.84e-09 58.5 COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,4HKMU@91061|Bacilli,1ZH3P@1386|Bacillus 91061|Bacilli K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_356474_1 1321779.HMPREF1984_00999 4.92e-05 44.7 COG2255@1|root,COG2255@2|Bacteria,3790M@32066|Fusobacteria 32066|Fusobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_356474_2 572544.Ilyop_1726 3.18e-59 186.0 COG1959@1|root,COG1959@2|Bacteria,37A40@32066|Fusobacteria 32066|Fusobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_389374_3 1565314.OA34_02435 5.36e-33 122.0 COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2YQ20@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EJ GlutRNAGln amidotransferase subunit D - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_389374_5 498211.CJA_1790 6.88e-40 140.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RY7P@1236|Gammaproteobacteria,1FG0N@10|Cellvibrio 1236|Gammaproteobacteria J RNA 2'-O ribose methyltransferase substrate binding - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_714895_1 267608.RSc1914 8.89e-07 58.9 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1NFKU@1224|Proteobacteria,2VPHV@28216|Betaproteobacteria,1KIM3@119060|Burkholderiaceae 28216|Betaproteobacteria D Phage tail tape measure protein TP901 - - - - - - - - - - - - PhageMin_Tail k59_714895_4 944547.ABLL_1888 2.64e-24 102.0 COG3500@1|root,COG3500@2|Bacteria,1MXT8@1224|Proteobacteria,42U7Z@68525|delta/epsilon subdivisions,2YPVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Phage late control gene D protein (GPD) - - - ko:K06905 - - - - ko00000 - - - Phage_GPD k59_845061_1 29581.BW37_04085 1.71e-09 63.5 COG4255@1|root,COG4255@2|Bacteria,1RA9X@1224|Proteobacteria,2WGEF@28216|Betaproteobacteria,47333@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - PhosphMutase k59_976087_1 400668.Mmwyl1_1915 1.24e-79 258.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1XKXU@135619|Oceanospirillales 135619|Oceanospirillales M COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily - - - - - - - - - - - - Sulfatase k59_552867_1 472759.Nhal_0219 4.48e-70 233.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales 135613|Chromatiales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_93809_1 575590.HMPREF0156_00095 2.41e-19 91.7 COG1404@1|root,COG2957@1|root,COG1404@2|Bacteria,COG2957@2|Bacteria,4NJ5R@976|Bacteroidetes 976|Bacteroidetes E cysteine-type endopeptidase activity - GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004198,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.22.37 ko:K08589 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_C25,Peptidase_C25_C,Propeptide_C25 k59_780485_1 243924.LT42_03600 4.48e-06 55.5 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - AHH,RHS,RHS_repeat k59_389376_1 1122134.KB893651_gene2071 2.79e-119 360.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1XMZK@135619|Oceanospirillales 135619|Oceanospirillales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_520698_1 234831.PSM_B0468 2.57e-171 487.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_976101_1 1379698.RBG1_1C00001G1686 1.69e-69 228.0 COG1217@1|root,COG1217@2|Bacteria,2NNY7@2323|unclassified Bacteria 2|Bacteria T Elongation factor G C-terminus typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2 k59_650014_1 1121396.KB893077_gene745 1.22e-19 92.4 COG1075@1|root,COG1075@2|Bacteria,1R5PF@1224|Proteobacteria,43BHB@68525|delta/epsilon subdivisions,2X6VQ@28221|Deltaproteobacteria,2MMMX@213118|Desulfobacterales 28221|Deltaproteobacteria S Alpha/beta hydrolase of unknown function (DUF915) - - - - - - - - - - - - DUF915 k59_584848_1 1504672.669786657 2.17e-27 114.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,4AAYF@80864|Comamonadaceae 28216|Betaproteobacteria C Resistance to Hg(2 ) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) merA - 1.16.1.1 ko:K00520 - - - - ko00000,ko01000 - - - HMA,Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_976116_1 83406.HDN1F_29010 1.81e-141 444.0 COG0433@1|root,COG0433@2|Bacteria,1NAXG@1224|Proteobacteria,1SJQR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 3'(2'),5'-bisphosphate nucleotidase activity - - - - - - - - - - - - Inovirus_Gp2 k59_161187_1 1408439.JHXW01000009_gene358 1.46e-43 152.0 COG0761@1|root,COG0761@2|Bacteria,3789B@32066|Fusobacteria 32066|Fusobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_161187_2 572544.Ilyop_1736 1.98e-43 142.0 COG1925@1|root,COG1925@2|Bacteria,37ACD@32066|Fusobacteria 32066|Fusobacteria G phosphocarrier, HPr family - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_257198_1 391598.FBBAL38_11864 1.05e-83 264.0 COG2067@1|root,COG2067@2|Bacteria,4NG1B@976|Bacteroidetes,1HY7J@117743|Flavobacteriia 976|Bacteroidetes I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_746083_1 323097.Nham_0882 2.88e-34 128.0 COG3900@1|root,COG3900@2|Bacteria,1NXBA@1224|Proteobacteria,2U3G3@28211|Alphaproteobacteria,3JX6G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Predicted periplasmic protein (DUF2092) - - - - - - - - - - - - DUF2092,OmpA k59_910827_1 1168034.FH5T_12845 2.24e-24 97.4 COG0092@1|root,COG0092@2|Bacteria,4NE9F@976|Bacteroidetes,2FMYX@200643|Bacteroidia 976|Bacteroidetes J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_910827_2 1168034.FH5T_12850 3.04e-89 262.0 COG0197@1|root,COG0197@2|Bacteria,4NM87@976|Bacteroidetes,2FRZE@200643|Bacteroidia 976|Bacteroidetes J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_910827_3 1168034.FH5T_12855 1.18e-23 91.3 COG0255@1|root,COG0255@2|Bacteria,4NUSC@976|Bacteroidetes,2FUJB@200643|Bacteroidia 976|Bacteroidetes J Belongs to the universal ribosomal protein uL29 family rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_910827_4 1408473.JHXO01000006_gene1291 2.21e-41 137.0 COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,2FTXY@200643|Bacteroidia 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_845069_1 1408439.JHXW01000004_gene1249 3.64e-16 82.0 COG1762@1|root,COG3711@1|root,COG1762@2|Bacteria,COG3711@2|Bacteria,379DZ@32066|Fusobacteria 32066|Fusobacteria K PRD domain protein - - - - - - - - - - - - HTH_11,Mga,PRD,PTS_EIIA_2 k59_552904_1 93220.LV28_09820 1.04e-30 118.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,1K263@119060|Burkholderiaceae 28216|Betaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_552904_2 1123253.AUBD01000006_gene814 2.23e-05 45.4 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1X3UI@135614|Xanthomonadales 135614|Xanthomonadales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_59589_1 1121938.AUDY01000004_gene366 2.1e-101 311.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,4H9TI@91061|Bacilli,3ND4C@45667|Halobacillus 91061|Bacilli I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_714929_1 243233.MCA1476 8.39e-42 151.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1XEKR@135618|Methylococcales 135618|Methylococcales F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_321098_1 929713.NIASO_06660 3.46e-70 232.0 COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,1IR0T@117747|Sphingobacteriia 976|Bacteroidetes H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_161198_1 96561.Dole_1452 1.21e-61 205.0 COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,43BPW@68525|delta/epsilon subdivisions,2X714@28221|Deltaproteobacteria,2MPJ0@213118|Desulfobacterales 28221|Deltaproteobacteria EGP PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 k59_161198_2 96561.Dole_1880 2.78e-110 324.0 COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,42MYE@68525|delta/epsilon subdivisions,2WJC7@28221|Deltaproteobacteria,2MIB6@213118|Desulfobacterales 28221|Deltaproteobacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_1009324_1 1200792.AKYF01000017_gene5566 4.69e-63 218.0 COG0300@1|root,COG1020@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae 91061|Bacilli Q Non-ribosomal peptide synthetase modules and related proteins pksM3 - - ko:K13611,ko:K13614,ko:K15654 ko01054,ko02024,map01054,map02024 - - - ko00000,ko00001,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_584883_1 1200792.AKYF01000017_gene5566 3.87e-67 230.0 COG0300@1|root,COG1020@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae 91061|Bacilli Q Non-ribosomal peptide synthetase modules and related proteins pksM3 - - ko:K13611,ko:K13614,ko:K15654 ko01054,ko02024,map01054,map02024 - - - ko00000,ko00001,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_23618_1 1443665.JACA01000034_gene2483 9.99e-10 58.9 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,1HWR3@117743|Flavobacteriia,2YJB6@290174|Aquimarina 976|Bacteroidetes G Glycosyl hydrolase family 92 - - - - - - - - - - - - Glyco_hydro_92 k59_23618_2 1168289.AJKI01000053_gene792 1.83e-38 144.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,2FMQ9@200643|Bacteroidia,3XKSH@558415|Marinilabiliaceae 976|Bacteroidetes G Glycosyl hydrolase family 92 - - - - - - - - - - - - Glyco_hydro_92 k59_62264_3 1123242.JH636434_gene5045 1.49e-106 337.0 COG0076@1|root,COG0076@2|Bacteria,2IZNW@203682|Planctomycetes 203682|Planctomycetes E Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC k59_62264_4 1286171.EAL2_c16810 4.96e-72 223.0 COG2431@1|root,COG2431@2|Bacteria,1V44M@1239|Firmicutes,24I3B@186801|Clostridia,25WZE@186806|Eubacteriaceae 186801|Clostridia S Pfam:DUF340 - - - - - - - - - - - - Lys_export k59_62264_5 350688.Clos_1659 7.34e-05 45.4 2EGX4@1|root,33AP9@2|Bacteria,1VNM0@1239|Firmicutes,24VYJ@186801|Clostridia 186801|Clostridia S Pfam:DUF340 - - - - - - - - - - - - Lys_export k59_62264_6 1499689.CCNN01000007_gene1275 1.94e-91 280.0 COG0697@1|root,COG0697@2|Bacteria,1TRKD@1239|Firmicutes,248I1@186801|Clostridia,36ENQ@31979|Clostridiaceae 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA k59_62264_7 1123075.AUDP01000019_gene1627 2.4e-27 100.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,3WKWV@541000|Ruminococcaceae 186801|Clostridia K 'Cold-shock' DNA-binding domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_62264_8 177437.HRM2_40420 2.21e-55 182.0 COG4619@1|root,COG4619@2|Bacteria,1NZKM@1224|Proteobacteria,42UAZ@68525|delta/epsilon subdivisions,2X74V@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ABC transporter - - - ko:K02068 - M00211 - - ko00000,ko00002,ko02000 - - - ABC_tran k59_62264_9 391623.TERMP_01383 1.18e-56 184.0 COG0500@1|root,arCOG04347@2157|Archaea,2XWKC@28890|Euryarchaeota,243JY@183968|Thermococci 183968|Thermococci Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_62264_10 572544.Ilyop_1458 3.27e-80 244.0 COG0730@1|root,COG0730@2|Bacteria,37869@32066|Fusobacteria 32066|Fusobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_62264_11 1195246.AGRI_06745 1.13e-16 78.2 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,1RRH4@1236|Gammaproteobacteria,4681F@72275|Alteromonadaceae 1236|Gammaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_1012020_1 945713.IALB_2306 4.02e-28 114.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4,6.3.5.5 ko:K01921,ko:K01955 ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502 M00051 R00256,R00575,R01150,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Dala_Dala_lig_C k59_129874_2 1168034.FH5T_01370 4.6e-119 345.0 COG0566@1|root,COG0566@2|Bacteria,4NF6H@976|Bacteroidetes,2FMSI@200643|Bacteroidia 976|Bacteroidetes J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family trmH - 2.1.1.185 ko:K03218,ko:K03437 - - - - ko00000,ko01000,ko03009,ko03016 - - - SpoU_methylase,SpoU_sub_bind k59_980057_2 326298.Suden_1117 1.8e-51 164.0 2AV85@1|root,31KYU@2|Bacteria,1QITS@1224|Proteobacteria,42SB2@68525|delta/epsilon subdivisions,2YQ0M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_980057_3 1249480.B649_07235 3.62e-81 244.0 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,42QSH@68525|delta/epsilon subdivisions,2YNVB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_881315_1 56780.SYN_01257 4.82e-51 170.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MQ77@213462|Syntrophobacterales 28221|Deltaproteobacteria E Bacterial transferase hexapeptide (six repeats) cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_63015_2 749222.Nitsa_1476 6.39e-56 185.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,42Q0J@68525|delta/epsilon subdivisions,2YPAY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S transport system, permease component - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_63015_3 326298.Suden_1844 3.13e-13 68.6 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,42M1Y@68525|delta/epsilon subdivisions,2YMJA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hydrolase aguB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_914455_1 1121459.AQXE01000001_gene2793 2.29e-67 212.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,42PJM@68525|delta/epsilon subdivisions,2WKJN@28221|Deltaproteobacteria,2M970@213115|Desulfovibrionales 28221|Deltaproteobacteria G Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_718874_1 96561.Dole_3119 9.53e-85 262.0 COG1146@1|root,COG1146@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - Fer4,Glu_synthase k59_813678_2 1548151.LS70_00870 3.83e-10 61.2 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YNB5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1045077_1 324057.Pjdr2_0698 1.53e-47 174.0 COG3170@1|root,COG4099@1|root,COG4932@1|root,COG3170@2|Bacteria,COG4099@2|Bacteria,COG4932@2|Bacteria,1UJE7@1239|Firmicutes,4IT6J@91061|Bacilli,2778B@186822|Paenibacillaceae 91061|Bacilli M S-layer homology domain - - - - - - - - - - - - CarboxypepD_reg,SLH k59_718881_1 575586.HMPREF0016_01429 4.14e-58 190.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,3NIX3@468|Moraxellaceae 1236|Gammaproteobacteria C Aldo/keto reductase family tas GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016491,GO:0016614,GO:0016616,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:1990928 - - - - - - - - - - Aldo_ket_red k59_261035_1 660470.Theba_2268 0.000215 49.3 COG2206@1|root,COG3290@1|root,COG3829@1|root,COG2206@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria 2|Bacteria T transcription factor binding - - - - - - - - - - - - GAF_2,GGDEF,HD,HD_5,MASE3,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_488520_1 411902.CLOBOL_07079 3.91e-108 332.0 COG2211@1|root,COG2211@2|Bacteria,1TSEH@1239|Firmicutes,25MPI@186801|Clostridia,21YWX@1506553|Lachnoclostridium 186801|Clostridia G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_423690_1 1220534.B655_0224 1.79e-19 93.2 COG0784@1|root,COG2203@1|root,COG3920@1|root,arCOG04001@1|root,arCOG06712@1|root,arCOG02335@2157|Archaea,arCOG02356@2157|Archaea,arCOG02357@2157|Archaea,arCOG04001@2157|Archaea,arCOG06537@2157|Archaea,arCOG06712@2157|Archaea 2157|Archaea T PAS domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_848737_1 411463.EUBVEN_00517 2.73e-05 45.1 2ED08@1|root,336X7@2|Bacteria,1VI3E@1239|Firmicutes,24TJC@186801|Clostridia 186801|Clostridia S COG NOG20805 non supervised orthologous group - - - - - - - - - - - - - k59_261039_1 1168034.FH5T_11150 1.36e-135 387.0 COG1738@1|root,COG1738@2|Bacteria 2|Bacteria S queuosine salvage CP_0548 - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_261039_2 742767.HMPREF9456_00862 8.33e-16 76.6 COG1649@1|root,COG1649@2|Bacteria,4NGFW@976|Bacteroidetes,2FPDY@200643|Bacteroidia,23055@171551|Porphyromonadaceae 976|Bacteroidetes S PFAM Uncharacterised BCR, COG1649 - - - - - - - - - - - - CBM9_1,GHL10 k59_980116_1 292415.Tbd_1426 1.11e-105 315.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,1KSTF@119069|Hydrogenophilales 119069|Hydrogenophilales P Sodium Bile acid symporter family - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_848744_1 290400.Jann_4230 7.49e-32 124.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2826 Transposase and inactivated derivatives, IS30 family - - - ko:K07482 - - - - ko00000 - - - HTH_32,HTH_38,rve k59_813705_1 1049564.TevJSym_ad00120 1.04e-37 141.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_813705_2 396588.Tgr7_1456 5.33e-55 172.0 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria,1WYKZ@135613|Chromatiales 135613|Chromatiales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA - - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_718916_2 1123252.ATZF01000002_gene2314 3.9e-39 142.0 COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,4H9WC@91061|Bacilli,27AVB@186824|Thermoactinomycetaceae 91061|Bacilli E Pyridoxal-phosphate dependent enzyme trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20,5.3.1.24 ko:K01696,ko:K01817 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722,R03509 RC00209,RC00210,RC00700,RC00701,RC00945,RC02868 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU22640 PALP k59_749808_1 1121405.dsmv_1784 0.0 1189.0 COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,42TK8@68525|delta/epsilon subdivisions,2WQUX@28221|Deltaproteobacteria,2MPB3@213118|Desulfobacterales 28221|Deltaproteobacteria L DEAD DEAH box helicase domain protein - - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,Helicase_C k59_749808_3 1121405.dsmv_1785 1.68e-69 221.0 2CE5F@1|root,2Z7YQ@2|Bacteria,1MXVM@1224|Proteobacteria,42Q53@68525|delta/epsilon subdivisions,2WJY4@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_325106_1 869213.JCM21142_94009 5.27e-78 244.0 COG1509@1|root,COG1509@2|Bacteria,4NJ79@976|Bacteroidetes 976|Bacteroidetes C lysine 2,3-aminomutase ablA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_325106_2 1168034.FH5T_13995 1.56e-62 210.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,4NGJ4@976|Bacteroidetes,2FN4R@200643|Bacteroidia 976|Bacteroidetes G trehalose-phosphatase otsB - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase k59_813709_1 96561.Dole_2493 1.74e-120 357.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,2MHRT@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM acetylornithine and succinylornithine argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iAF987.Gmet_0204 Aminotran_3 k59_292342_1 631362.Thi970DRAFT_02209 9.3e-75 234.0 COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,1RRC5@1236|Gammaproteobacteria,1WXE3@135613|Chromatiales 135613|Chromatiales G PFAM Fructosamine - - - - - - - - - - - - Fructosamin_kin k59_1012848_1 519989.ECTPHS_07067 3.03e-72 245.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_653731_3 1112209.AHVZ01000017_gene712 3.16e-15 88.6 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,3NKB9@468|Moraxellaceae 1236|Gammaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HCBP_related,He_PIG,HemolysinCabind k59_813712_1 1121931.AUHG01000020_gene3120 1.52e-25 113.0 COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1HXNY@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - CarboxypepD_reg,OmpA,PD40 k59_423743_1 1123065.ATWL01000001_gene551 8.98e-109 324.0 COG0719@1|root,COG0719@2|Bacteria,2GJNV@201174|Actinobacteria 201174|Actinobacteria O FeS assembly protein SufD sufD GO:0008150,GO:0009605,GO:0009607,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 - ko:K09015 - - - - ko00000 - - - UPF0051 k59_1045112_1 340177.Cag_0614 1.79e-22 102.0 COG1357@1|root,COG2931@1|root,COG3210@1|root,COG4625@1|root,COG1357@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis rhgB - 4.2.2.23 ko:K07004,ko:K18195 - - - - ko00000,ko01000 - PL4 - CBM-like,RhgB_N,fn3_3 k59_718956_1 861299.J421_4478 1.1e-89 281.0 COG1574@1|root,COG1574@2|Bacteria,1ZU9S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_292358_1 1168034.FH5T_17500 1.93e-94 306.0 COG3422@1|root,COG3422@2|Bacteria,4NHE4@976|Bacteroidetes,2G18X@200643|Bacteroidia 976|Bacteroidetes S double-strand break repair - - - - - - - - - - - - - k59_848779_1 879212.DespoDRAFT_03020 6.63e-44 146.0 2CDHP@1|root,32RXU@2|Bacteria,1N1BP@1224|Proteobacteria,42TPT@68525|delta/epsilon subdivisions,2WQE6@28221|Deltaproteobacteria,2MJZK@213118|Desulfobacterales 28221|Deltaproteobacteria S RsbT co-antagonist protein rsbRD N-terminal domain - - - - - - - - - - - - RsbRD_N k59_848779_2 1121396.KB893035_gene3580 5.79e-62 198.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria,2MI6J@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Nitrate_red_gam k59_325158_1 530564.Psta_1712 3.46e-37 134.0 28I6Y@1|root,2Z89T@2|Bacteria 2|Bacteria S SseB protein C-terminal domain sseB - - - - - - - - - - - SseB,SseB_C k59_27154_1 237368.SCABRO_03229 1.27e-19 95.1 COG3291@1|root,COG4733@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - - - - - - - - - - CBM_6,Laminin_G_3,PKD,PPC,Phage-tail_3,Reprolysin_3,fn3 k59_1012872_1 690850.Desaf_0969 1.5e-65 212.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2M8GR@213115|Desulfovibrionales 28221|Deltaproteobacteria T SMART Nucleotide binding protein, PINc phoH1 - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_423767_1 1249480.B649_01125 2.22e-179 517.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_63114_1 1408473.JHXO01000007_gene826 1.92e-14 73.9 COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - HTH_18,TPR_8 k59_325192_2 56780.SYN_00674 3.08e-47 165.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,42MTV@68525|delta/epsilon subdivisions,2WKVP@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 k59_261088_2 1395571.TMS3_0103630 9.64e-19 78.2 COG1773@1|root,COG1773@2|Bacteria 2|Bacteria C rubredoxin rubA - - ko:K03618 - - - - ko00000 - - - HupH_C,Rubredoxin k59_261088_3 1348657.M622_13735 4.04e-99 301.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2VPD5@28216|Betaproteobacteria,2KWNS@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome P450 - - - - - - - - - - - - p450 k59_63137_1 439375.Oant_2555 2.85e-101 305.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,1J1P7@118882|Brucellaceae 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component aapM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_813774_1 1249480.B649_07990 9.32e-87 270.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2YMGC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_261091_1 1196029.ALIM01000049_gene4663 8.37e-34 126.0 COG0673@1|root,COG0673@2|Bacteria,1TRHA@1239|Firmicutes,4HA6R@91061|Bacilli,1ZENE@1386|Bacillus 91061|Bacilli S Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively iolG - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_97624_1 1049564.TevJSym_ap00190 5.15e-59 195.0 COG1073@1|root,COG1073@2|Bacteria,1MY4C@1224|Proteobacteria,1RNS3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S alpha beta - - - - - - - - - - - - Hydrolase_4 k59_97624_2 748658.KB907318_gene994 8.17e-53 185.0 COG2215@1|root,COG2215@2|Bacteria,1MWIW@1224|Proteobacteria,1RQ9T@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the NiCoT transporter (TC 2.A.52) family yohM - - ko:K08970 - - - - ko00000,ko02000 2.A.52.2 - - NicO k59_97624_3 1266909.AUAG01000026_gene1936 1.61e-40 145.0 COG3683@1|root,COG3683@2|Bacteria,1R4QA@1224|Proteobacteria,1RQ73@1236|Gammaproteobacteria 1236|Gammaproteobacteria S transport system periplasmic component Z012_08265 - - ko:K06925 - - - - ko00000,ko03016 - - - DUF1007 k59_97624_5 1049564.TevJSym_aa01810 0.0 947.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter sac1 - - - - - - - - - - - CitMHS,TrkA_C k59_97624_6 391625.PPSIR1_19854 0.000424 47.8 COG1595@1|root,COG1595@2|Bacteria,1PEYN@1224|Proteobacteria,42ST1@68525|delta/epsilon subdivisions 1224|Proteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_97624_7 104623.Ser39006_02385 2.56e-09 55.8 COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria,1SH4J@1236|Gammaproteobacteria,405E8@613|Serratia 1236|Gammaproteobacteria S Putative zinc-finger - - - - - - - - - - - - zf-HC2 k59_97624_9 1266925.JHVX01000007_gene2372 1.19e-126 369.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKP0@28216|Betaproteobacteria,372US@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_97624_10 1411685.U062_00408 5.63e-48 166.0 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1J6PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_97624_11 396588.Tgr7_2637 7.12e-53 171.0 COG2259@1|root,COG2259@2|Bacteria,1RDRZ@1224|Proteobacteria,1SA8P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DoxX family - - - ko:K15977 - - - - ko00000 - - - DoxX k59_97624_12 631362.Thi970DRAFT_02651 7.06e-197 560.0 COG0225@1|root,COG0229@1|root,COG0526@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,COG0526@2|Bacteria,1MVUS@1224|Proteobacteria,1T0T1@1236|Gammaproteobacteria,1X2MT@135613|Chromatiales 135613|Chromatiales CO Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11,1.8.4.12 ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR,Thioredoxin_2 k59_97624_14 1307759.JOMJ01000003_gene2266 2.26e-43 143.0 COG1633@1|root,COG1633@2|Bacteria,1RKE9@1224|Proteobacteria,42UNE@68525|delta/epsilon subdivisions,2WQ3F@28221|Deltaproteobacteria,2MF71@213115|Desulfovibrionales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - COQ7,Rubrerythrin k59_97624_15 105559.Nwat_1216 2.12e-43 142.0 COG2119@1|root,COG2119@2|Bacteria,1N85A@1224|Proteobacteria,1SAAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_97624_17 1121878.AUGL01000005_gene2659 6.67e-26 101.0 COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,1SAI5@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5,LMWPc k59_97624_18 2340.JV46_04680 2.41e-39 131.0 COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,1SCEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO redox-active disulfide protein 2 - - - - - - - - - - - - DUF2892,Thioredoxin_3 k59_97624_19 1249627.D779_2579 3.95e-171 484.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RR9N@1236|Gammaproteobacteria,1WX27@135613|Chromatiales 135613|Chromatiales S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_97624_20 1217713.F993_00047 4.85e-128 382.0 COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,1RP20@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - - - - - - - - - - DUF2235 k59_83230_1 1168034.FH5T_19670 7.53e-147 438.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolase family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 k59_574109_1 933262.AXAM01000008_gene1943 1.14e-83 274.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MHQD@213118|Desulfobacterales 28221|Deltaproteobacteria F Carbamoyl-phosphate synthetase large chain oligomerisation carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_475255_1 563040.Saut_1194 1.19e-129 385.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2YMJV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_475255_2 1537917.JU82_01050 7.98e-66 205.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2YNXC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iIT341.HP0618 ADK k59_509868_1 1121405.dsmv_2273 4.52e-12 67.4 COG2823@1|root,COG2823@2|Bacteria,1Q1QW@1224|Proteobacteria,42U7A@68525|delta/epsilon subdivisions,2X5PY@28221|Deltaproteobacteria,2MKM2@213118|Desulfobacterales 28221|Deltaproteobacteria S BON domain - - - ko:K04065 - - - - ko00000 - - - BON k59_509868_2 713586.KB900536_gene1251 1.01e-18 79.7 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1WYMA@135613|Chromatiales 135613|Chromatiales O Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_672810_1 387093.SUN_1790 1.76e-49 166.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,42N1M@68525|delta/epsilon subdivisions,2YN3T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_672810_2 387093.SUN_1791 5.23e-27 107.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2YMSV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E o-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_999248_1 103733.JNYO01000046_gene6567 4.58e-31 127.0 COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4DZDB@85010|Pseudonocardiales 201174|Actinobacteria Q polyketide synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_672812_1 501479.ACNW01000115_gene3947 2.43e-77 240.0 COG1052@1|root,COG1052@2|Bacteria,1QVZS@1224|Proteobacteria,2TUUQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.29,1.1.1.399,1.1.1.95 ko:K00018,ko:K00058 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00020,M00346 R00717,R01388,R01513 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_377668_1 1158610.UC3_02567 6.61e-16 79.0 COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,4HC4A@91061|Bacilli,4B13C@81852|Enterococcaceae 91061|Bacilli C Produces ATP from ADP in the presence of a proton gradient across the membrane ntpD - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_1030629_1 1537917.JU82_10415 2.15e-46 159.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2YM81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Cysteine desulfurase iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1030629_3 1249480.B649_06830 2.78e-34 123.0 297UU@1|root,2ZV1D@2|Bacteria,1MXFE@1224|Proteobacteria,430YU@68525|delta/epsilon subdivisions,2YS1X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_442078_1 329726.AM1_0134 3.37e-24 99.8 COG1260@1|root,COG1260@2|Bacteria,1G0I9@1117|Cyanobacteria 1117|Cyanobacteria I Myo-inositol-1-phosphate synthase ino1 - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_116278_1 1047013.AQSP01000103_gene1160 1.95e-65 221.0 COG1770@1|root,COG1770@2|Bacteria,2NNMF@2323|unclassified Bacteria 2|Bacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain ptrB GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_116278_2 1168034.FH5T_17755 1.57e-29 115.0 COG0591@1|root,COG0591@2|Bacteria,4NH7H@976|Bacteroidetes 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307,ko:K14387 ko04725,ko05231,map04725,map05231 - - - ko00000,ko00001,ko02000 2.A.21,2.A.21.8 - - HD_4,SSF k59_607179_1 396588.Tgr7_0047 6.92e-63 204.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1WW4W@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1030635_1 196367.JNFG01000044_gene1645 7.36e-89 274.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIX2@28216|Betaproteobacteria,1K2AF@119060|Burkholderiaceae 28216|Betaproteobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_607182_1 986075.CathTA2_3002 6.75e-62 215.0 COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,4HBX7@91061|Bacilli 91061|Bacilli KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iYO844.BSU27600 ACT_4,HD_4,RelA_SpoT,TGS k59_736030_1 572544.Ilyop_0960 3.26e-24 95.9 COG0494@1|root,COG0494@2|Bacteria,378TQ@32066|Fusobacteria 32066|Fusobacteria L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_640333_2 1283300.ATXB01000001_gene249 3.1e-48 162.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1XEM4@135618|Methylococcales 135618|Methylococcales H Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_542405_1 1443665.JACA01000050_gene2120 7.26e-59 195.0 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1HXW9@117743|Flavobacteriia,2YI5P@290174|Aquimarina 976|Bacteroidetes M Biotin-lipoyl like - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_378316_1 2340.JV46_15700 5.86e-77 253.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1J56C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_13513_1 105559.Nwat_3036 2.71e-120 354.0 COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,1RZ5M@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_1031331_1 1122603.ATVI01000007_gene1660 1.22e-40 150.0 COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,1RPFY@1236|Gammaproteobacteria,1XD6R@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase-like ATPases - - 2.7.13.3 ko:K07637 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HATPase_c k59_835818_1 1168034.FH5T_21250 1.11e-88 277.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,4NFCF@976|Bacteroidetes,2FNDY@200643|Bacteroidia 976|Bacteroidetes P Chloride transporter, ClC family clcB - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_835818_2 493475.GARC_3397 1.62e-08 56.6 COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,1RNUR@1236|Gammaproteobacteria,469VA@72275|Alteromonadaceae 1236|Gammaproteobacteria E Asparaginase aga - 3.5.1.1,3.5.1.26 ko:K01424,ko:K01444 ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase_2 k59_673492_1 1125863.JAFN01000001_gene2334 3.83e-49 160.0 COG3744@1|root,COG3744@2|Bacteria,1RJ4K@1224|Proteobacteria,42WUI@68525|delta/epsilon subdivisions,2WT5M@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_312026_1 1217705.F900_02708 2.98e-11 60.5 COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria,1SH4J@1236|Gammaproteobacteria,3NPW6@468|Moraxellaceae 1236|Gammaproteobacteria S Transmembrane anti-sigma factor - - - - - - - - - - - - zf-HC2 k59_247354_1 1323663.AROI01000020_gene721 4.5e-08 59.7 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_475892_1 1168034.FH5T_22110 8.33e-45 158.0 COG0205@1|root,COG0205@2|Bacteria,4NIKT@976|Bacteroidetes,2FNYX@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_475892_2 1121945.ATXS01000004_gene975 1.19e-16 75.1 COG3478@1|root,arCOG05073@2157|Archaea,2Y03G@28890|Euryarchaeota,23XMS@183963|Halobacteria 183963|Halobacteria S nucleic-acid-binding protein containing a Zn-ribbon domain - - - ko:K07069 - - - - ko00000 - - - zinc_ribbon_13 k59_999874_1 103690.17131374 1.08e-08 61.6 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GRE7@1117|Cyanobacteria,1HRR4@1161|Nostocales 1117|Cyanobacteria KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_640358_1 1408439.JHXW01000008_gene293 2.32e-67 207.0 COG0691@1|root,COG0691@2|Bacteria,379WW@32066|Fusobacteria 32066|Fusobacteria O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_183252_2 207954.MED92_03508 3.59e-23 93.2 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1XK9E@135619|Oceanospirillales 135619|Oceanospirillales K Transcriptional - - - ko:K22042 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 k59_183252_3 91464.S7335_4934 3.94e-10 62.0 COG0748@1|root,COG0748@2|Bacteria,1GJCT@1117|Cyanobacteria,1H2BJ@1129|Synechococcus 1117|Cyanobacteria P Pyridoxamine 5'-phosphate oxidase family protein - - - - - - - - - - - - Putative_PNPOx k59_934476_1 1168034.FH5T_05725 9.48e-52 177.0 COG0591@1|root,COG0591@2|Bacteria,4NEF3@976|Bacteroidetes,2FM9G@200643|Bacteroidia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_278597_1 1237149.C900_03625 2.83e-14 77.8 COG3227@1|root,COG3291@1|root,COG4733@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,4NGRJ@976|Bacteroidetes,47JD6@768503|Cytophagia 976|Bacteroidetes O PFAM Pregnancy-associated plasma protein-A - - - - - - - - - - - - Peptidase_M43,fn3 k59_901285_1 1121434.AULY01000014_gene2754 4.13e-29 122.0 COG4191@1|root,COG4192@1|root,COG4191@2|Bacteria,COG4192@2|Bacteria,1RCM9@1224|Proteobacteria,439Y7@68525|delta/epsilon subdivisions,2X1VF@28221|Deltaproteobacteria,2MAY2@213115|Desulfovibrionales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K10125 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 k59_607810_1 1168034.FH5T_14955 1.43e-267 741.0 COG1142@1|root,COG4624@1|root,COG1142@2|Bacteria,COG4624@2|Bacteria,4NGF4@976|Bacteroidetes,2FPND@200643|Bacteroidia 976|Bacteroidetes C COG4624 Iron only hydrogenase large subunit C-terminal domain - - - - - - - - - - - - Fe_hyd_lg_C,Fer4 k59_901293_1 631362.Thi970DRAFT_03923 3.09e-46 163.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales 135613|Chromatiales M PFAM Three-deoxy-D-manno-octulosonic-acid transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N,Kdo k59_901293_2 589865.DaAHT2_1103 5.91e-25 103.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,2MJ7E@213118|Desulfobacterales 28221|Deltaproteobacteria H Bifunctional protein hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF987.Gmet_0922 CTP_transf_like,PfkB k59_966740_1 1122609.AUGT01000013_gene4105 2.04e-27 116.0 COG2909@1|root,COG2909@2|Bacteria,2I50W@201174|Actinobacteria,4DPMG@85009|Propionibacteriales 201174|Actinobacteria K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE k59_934486_2 1177154.Y5S_01973 8.49e-27 104.0 28JTN@1|root,2Z9IV@2|Bacteria,1RCK3@1224|Proteobacteria,1S21G@1236|Gammaproteobacteria,1XPME@135619|Oceanospirillales 135619|Oceanospirillales S Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_770478_1 572544.Ilyop_0660 3.08e-164 496.0 COG0642@1|root,COG5000@1|root,COG0642@2|Bacteria,COG5000@2|Bacteria,3784S@32066|Fusobacteria 32066|Fusobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HAMP,HATPase_c k59_770478_2 572544.Ilyop_0661 0.0 916.0 COG0060@1|root,COG0060@2|Bacteria,3788C@32066|Fusobacteria 32066|Fusobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_542447_1 1121015.N789_12040 4.34e-133 402.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2BS@1236|Gammaproteobacteria,1XDAE@135614|Xanthomonadales 135614|Xanthomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_247408_1 1123278.KB893579_gene883 3.89e-29 120.0 28JZQ@1|root,2Z9PN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_770484_2 1408473.JHXO01000001_gene2382 2.34e-73 238.0 COG3408@1|root,COG3408@2|Bacteria,4NF09@976|Bacteroidetes,2FMEX@200643|Bacteroidia 976|Bacteroidetes G Glycogen debranching enzyme, archaeal type - - - - - - - - - - - - GDE_C,GDE_N k59_510505_1 929556.Solca_1503 8e-23 100.0 COG3119@1|root,COG3119@2|Bacteria,4NEBN@976|Bacteroidetes,1IQGE@117747|Sphingobacteriia 976|Bacteroidetes P PFAM sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_510505_2 1121875.KB907550_gene636 5.66e-17 80.9 COG2015@1|root,COG2015@2|Bacteria,4NJE2@976|Bacteroidetes 976|Bacteroidetes Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_312077_1 977880.RALTA_A0448 2.66e-68 213.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,1K14P@119060|Burkholderiaceae 28216|Betaproteobacteria S phospholipid-binding protein bbsI - - ko:K06910 - - - - ko00000 - - - PBP k59_475919_1 1265505.ATUG01000001_gene3423 9.86e-23 89.7 COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,42UIZ@68525|delta/epsilon subdivisions,2WQ43@28221|Deltaproteobacteria,2MPDN@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative heavy-metal-binding - - - - - - - - - - - - YbjQ_1 k59_475919_2 1029823.AFIE01000009_gene1699 3.74e-21 90.5 COG0393@1|root,COG0393@2|Bacteria,1N6BK@1224|Proteobacteria,1SAFJ@1236|Gammaproteobacteria,3NN5K@468|Moraxellaceae 1236|Gammaproteobacteria S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k59_475919_3 391612.CY0110_03454 1.56e-30 122.0 COG4783@1|root,COG4783@2|Bacteria,1G3BT@1117|Cyanobacteria,3KHB6@43988|Cyanothece 1117|Cyanobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_475919_4 1537917.JU82_06900 7.62e-139 418.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2YMTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_378363_1 395493.BegalDRAFT_0708 5.62e-67 224.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,45ZU0@72273|Thiotrichales 72273|Thiotrichales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_510513_1 1121481.AUAS01000003_gene4026 2.67e-22 93.2 COG0071@1|root,COG0071@2|Bacteria,4NQXY@976|Bacteroidetes,47R7Q@768503|Cytophagia 976|Bacteroidetes O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_999906_1 439235.Dalk_3030 1.7e-103 313.0 COG2944@1|root,COG4279@1|root,COG2944@2|Bacteria,COG4279@2|Bacteria,1N5C3@1224|Proteobacteria,42QFI@68525|delta/epsilon subdivisions,2WKF8@28221|Deltaproteobacteria,2MIDB@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM zinc finger SWIM domain protein - - - - - - - - - - - - SWIM k59_999906_2 83406.HDN1F_23130 1.25e-66 224.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria 1236|Gammaproteobacteria KL COG0553 Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - DUF3670,Helicase_C,SNF2_N,SWIM k59_117002_1 439235.Dalk_0317 9.02e-85 256.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2MJ2V@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_934498_1 1249997.JHZW01000003_gene2534 4.48e-12 70.9 COG3656@1|root,COG3656@2|Bacteria,4NNP1@976|Bacteroidetes,1I2FU@117743|Flavobacteriia 976|Bacteroidetes S Periplasmic Protein - - - - - - - - - - - - Kelch_3,TIG k59_510530_1 999541.bgla_1g05510 7.28e-60 192.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,1JZZV@119060|Burkholderiaceae 28216|Betaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_312085_1 1168034.FH5T_18910 1.95e-38 146.0 COG0823@1|root,COG0823@2|Bacteria,4NGPR@976|Bacteroidetes,2FNGJ@200643|Bacteroidia 976|Bacteroidetes U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - - k59_736720_1 1211114.ALIP01000127_gene572 1.98e-147 429.0 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1X2YX@135614|Xanthomonadales 135614|Xanthomonadales E phospho-2-dehydro-3-deoxyheptonate aldolase dhs1 - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_2 k59_410764_1 240302.BN982_03004 1.31e-27 116.0 COG0381@1|root,COG0381@2|Bacteria,1UXZI@1239|Firmicutes,4HCHF@91061|Bacilli,3ND7D@45667|Halobacillus 91061|Bacilli M UDP-N-acetylglucosamine 2-epimerase activity - - - - - - - - - - - - - k59_475944_1 387093.SUN_1243 7.58e-155 451.0 COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria,43CEV@68525|delta/epsilon subdivisions,2YRH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_999910_1 393595.ABO_2597 8.81e-64 206.0 COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,1XHSC@135619|Oceanospirillales 135619|Oceanospirillales P Iron deficiency-induced protein A - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_1031392_1 1044.EH31_02115 3.17e-46 169.0 COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,2VEV5@28211|Alphaproteobacteria,2K7TR@204457|Sphingomonadales 204457|Sphingomonadales S K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - Sortilin-Vps10 k59_934512_1 998088.B565_0278 3.84e-96 291.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1Y42T@135624|Aeromonadales 135624|Aeromonadales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_934512_2 765912.Thimo_1360 3.2e-13 68.9 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales 135613|Chromatiales H Uroporphyrinogen III synthase - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_117017_1 630626.EBL_c29780 2.39e-06 49.7 COG4381@1|root,COG4381@2|Bacteria,1N954@1224|Proteobacteria,1S7NU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage protein GP46 - - - - - - - - - - - - GP46 k59_117018_1 622637.KE124774_gene1787 9.65e-19 85.1 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,36ZYD@31993|Methylocystaceae 28211|Alphaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_934516_1 1182553.XP_007746520.1 7.12e-05 48.1 COG1231@1|root,KOG0029@2759|Eukaryota,38B4W@33154|Opisthokonta,3NYHX@4751|Fungi,3QNZG@4890|Ascomycota,20EAH@147545|Eurotiomycetes 4751|Fungi Q amine oxidase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase,Ribonuc_L-PSP k59_580328_2 1265505.ATUG01000001_gene3527 2.87e-38 144.0 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,42N95@68525|delta/epsilon subdivisions,2WJ0N@28221|Deltaproteobacteria,2MIKM@213118|Desulfobacterales 28221|Deltaproteobacteria N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_156515_1 1121441.AUCX01000005_gene1398 1.44e-42 158.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MG2T@213115|Desulfovibrionales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_448807_1 1415778.JQMM01000001_gene437 1.41e-40 149.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1J5VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases ubiH GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008681,GO:0009058,GO:0009108,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03185,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R04989,R08768,R08773 RC00046,RC02670 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_02702,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECD_1391.ECD_02739,iEcHS_1320.EcHS_A3066 FAD_binding_3 k59_776165_1 1049564.TevJSym_ai00970 1.13e-92 291.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J53A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_1005467_1 1165841.SULAR_03108 7.16e-52 174.0 COG0561@1|root,COG0561@2|Bacteria,1Q5G6@1224|Proteobacteria,42R7D@68525|delta/epsilon subdivisions,2YP2E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S of the HAD superfamily - - - - - - - - - - - - Hydrolase_3 k59_711013_1 1168034.FH5T_11115 9.65e-95 287.0 COG0527@1|root,COG0527@2|Bacteria,4NF0M@976|Bacteroidetes,2G2TX@200643|Bacteroidia 976|Bacteroidetes E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_711013_2 1168034.FH5T_11110 2.71e-08 54.3 COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes,2FW6G@200643|Bacteroidia 976|Bacteroidetes M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_D23,OEP k59_940024_2 572544.Ilyop_0066 7.23e-37 130.0 COG1396@1|root,COG2932@1|root,COG1396@2|Bacteria,COG2932@2|Bacteria,37927@32066|Fusobacteria 2|Bacteria K Peptidase S24-like XK27_10050 - - - - - - - - - - - HTH_19,HTH_3,Peptidase_S24 k59_972255_1 411463.EUBVEN_01172 1.11e-31 118.0 COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,25V3K@186806|Eubacteriaceae 186801|Clostridia H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_972255_2 665950.HMPREF1025_01065 2.19e-119 350.0 COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,27K47@186928|unclassified Lachnospiraceae 186801|Clostridia H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_972255_3 545697.HMPREF0216_00481 1.03e-63 197.0 COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,36K0M@31979|Clostridiaceae 186801|Clostridia H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_972255_4 481448.Minf_0152 6.33e-72 252.0 COG1331@1|root,COG1331@2|Bacteria,46SEJ@74201|Verrucomicrobia,37G3S@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_972255_5 994573.T472_0208745 2.23e-52 180.0 COG1737@1|root,COG1737@2|Bacteria,1TPIX@1239|Firmicutes,24AKZ@186801|Clostridia,36WUB@31979|Clostridiaceae 186801|Clostridia K transcriptional regulator, RpiR family - - - - - - - - - - - - HTH_6,SIS k59_972255_7 986075.CathTA2_0530 7.55e-188 538.0 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1TPJ8@1239|Firmicutes,4HA8X@91061|Bacilli 91061|Bacilli G pts system nagE - 2.7.1.193,2.7.1.199 ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00267,M00809 R02738,R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_972255_8 1278306.KB906912_gene849 5.75e-145 414.0 COG0363@1|root,COG0363@2|Bacteria,378PK@32066|Fusobacteria 32066|Fusobacteria G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso k59_972255_9 469616.FMAG_01735 3.69e-141 413.0 COG1820@1|root,COG1820@2|Bacteria,378VQ@32066|Fusobacteria 32066|Fusobacteria G Belongs to the metallo-dependent hydrolases superfamily. NagA family - - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_972255_10 1321779.HMPREF1984_00746 3.24e-40 140.0 COG2190@1|root,COG2190@2|Bacteria,37A1G@32066|Fusobacteria 32066|Fusobacteria G PTS system crr - - ko:K02777 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1 - - PTS_EIIA_1 k59_972255_11 999411.HMPREF1092_02766 1.61e-44 153.0 COG1182@1|root,COG1182@2|Bacteria,1UZBY@1239|Firmicutes,248VP@186801|Clostridia,36DWT@31979|Clostridiaceae 186801|Clostridia I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity azoR - - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 k59_972255_12 1423767.BALU01000008_gene515 1.06e-12 71.2 COG4939@1|root,COG4939@2|Bacteria,1TSWI@1239|Firmicutes,4IR0S@91061|Bacilli,3FBKI@33958|Lactobacillaceae 91061|Bacilli S FMN_bind - - - - - - - - - - - - FMN_bind k59_972255_13 523791.Kkor_1759 6.8e-25 113.0 COG4872@1|root,COG4872@2|Bacteria,1N3FM@1224|Proteobacteria 1224|Proteobacteria S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157 k59_972255_14 1123256.KB907930_gene3568 2.7e-15 77.4 COG4929@1|root,COG4929@2|Bacteria,1NCJA@1224|Proteobacteria,1SJH8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S GDYXXLXY protein - - - - - - - - - - - - GDYXXLXY k59_972255_15 572480.Arnit_0947 2.73e-153 445.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2YMB7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_972255_16 865861.AZSU01000004_gene992 8.89e-91 285.0 COG1251@1|root,COG1251@2|Bacteria,1UI2I@1239|Firmicutes,25EB3@186801|Clostridia,36UJ1@31979|Clostridiaceae 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase nasD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015044,GO:0016491,GO:0016730,GO:0016731,GO:0017144,GO:0022900,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0072592,GO:0097159,GO:1901265,GO:1901363 1.6.3.4,1.7.1.15 ko:K00362,ko:K22405 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2 k59_972255_18 469616.FMAG_00786 6.17e-253 717.0 COG0514@1|root,COG0514@2|Bacteria,3790Q@32066|Fusobacteria 32066|Fusobacteria L RQC recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_972255_19 526218.Sterm_1133 5.01e-69 217.0 COG0745@1|root,COG0745@2|Bacteria,379HE@32066|Fusobacteria 32066|Fusobacteria K Psort location Cytoplasmic, score 9.97 - - - - - - - - - - - - Response_reg,Trans_reg_C k59_972255_20 1120985.AUMI01000011_gene484 1.64e-40 156.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4H9CQ@909932|Negativicutes 909932|Negativicutes T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_188950_2 1165841.SULAR_00170 1.6e-38 131.0 COG2608@1|root,COG2608@2|Bacteria,1N81B@1224|Proteobacteria,42VKI@68525|delta/epsilon subdivisions,2YQD5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Heavy-metal-associated domain - - - - - - - - - - - - HMA k59_188950_3 1172190.M947_00410 5.76e-11 62.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2YMZR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_156533_1 1453501.JELR01000002_gene347 6.88e-21 86.7 2EQ5T@1|root,32ZV0@2|Bacteria,1NFTI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_156533_2 1232410.KI421425_gene1548 1.55e-37 131.0 COG0457@1|root,COG0457@2|Bacteria,1N1J2@1224|Proteobacteria,42ZHG@68525|delta/epsilon subdivisions,2WV2W@28221|Deltaproteobacteria,43UR6@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1037006_1 1094556.MCY_01545 5.79e-07 51.6 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,48T74@772|Bartonellaceae 28211|Alphaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_805466_1 1049564.TevJSym_ai00520 5.94e-74 247.0 COG2199@1|root,COG4223@1|root,COG2199@2|Bacteria,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1J4ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_221306_1 316279.Syncc9902_0330 1.07e-29 120.0 COG1090@1|root,COG1090@2|Bacteria,1G1NR@1117|Cyanobacteria,1GYJI@1129|Synechococcus 1117|Cyanobacteria S epimerase - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_940030_1 1517416.IDAT_09080 9.64e-57 191.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,2QF7V@267893|Idiomarinaceae 1236|Gammaproteobacteria HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - Dala_Dala_lig_C,RLAN,RimK k59_646209_1 1198232.CYCME_0392 3.2e-90 275.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,4613M@72273|Thiotrichales 72273|Thiotrichales S Sodium Bile acid symporter family - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_679360_1 305700.B447_17701 2.87e-90 279.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,2KUI1@206389|Rhodocyclales 206389|Rhodocyclales C Glycolate oxidase subunit GlcD glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_711024_1 1168034.FH5T_19435 4.96e-29 111.0 COG0623@1|root,COG0623@2|Bacteria,4NEVE@976|Bacteroidetes,2FM85@200643|Bacteroidia 976|Bacteroidetes I Enoyl- acyl-carrier-protein reductase NADH fabI - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_972268_1 709991.Odosp_2182 5.47e-33 118.0 COG3829@1|root,COG3829@2|Bacteria,4NUDP@976|Bacteroidetes,2FU2M@200643|Bacteroidia,22YF1@171551|Porphyromonadaceae 976|Bacteroidetes KT Diguanylate cyclase - - - - - - - - - - - - PAS_4 k59_972268_2 1121904.ARBP01000028_gene1646 3.04e-08 55.8 COG1752@1|root,COG1752@2|Bacteria,4NDXY@976|Bacteroidetes 976|Bacteroidetes M esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_613636_1 1121456.ATVA01000014_gene635 2.97e-24 106.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1N4K5@1224|Proteobacteria,42RTP@68525|delta/epsilon subdivisions,2WN9M@28221|Deltaproteobacteria,2M9XH@213115|Desulfovibrionales 28221|Deltaproteobacteria T Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - PAS_8,Response_reg,SpoIIE k59_805479_1 686340.Metal_0069 1.31e-74 235.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1XDYG@135618|Methylococcales 135618|Methylococcales E Aminotransferase, class I - - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_317562_1 702450.CUW_1953 5.2e-66 218.0 COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,3VPSA@526524|Erysipelotrichia 526524|Erysipelotrichia S Putative modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD k59_317562_2 1319815.HMPREF0202_02980 1e-46 162.0 COG0312@1|root,COG0312@2|Bacteria,3795R@32066|Fusobacteria 32066|Fusobacteria S Putative modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_940049_1 1469557.JSWF01000014_gene2532 5.9e-28 108.0 COG2849@1|root,COG2849@2|Bacteria,4NP2Z@976|Bacteroidetes,1I22V@117743|Flavobacteriia 976|Bacteroidetes S protein conserved in bacteria - - - - - - - - - - - - MORN_2 k59_940049_2 1347342.BN863_8230 1.76e-14 73.2 COG0706@1|root,COG0706@2|Bacteria,4NESJ@976|Bacteroidetes,1HWSE@117743|Flavobacteriia 976|Bacteroidetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_352579_1 156889.Mmc1_2504 1.11e-47 164.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,2U4H3@28211|Alphaproteobacteria 28211|Alphaproteobacteria C PFAM Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_352579_2 156889.Mmc1_2503 5.34e-64 210.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_481329_1 767817.Desgi_1004 1.13e-121 378.0 COG0610@1|root,COG0610@2|Bacteria,1TP7S@1239|Firmicutes,248A6@186801|Clostridia,2610J@186807|Peptococcaceae 186801|Clostridia V Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_481329_2 1454007.JAUG01000021_gene1175 2.6e-08 56.2 2CIUD@1|root,33B3M@2|Bacteria,4P78Q@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_19320_1 748658.KB907312_gene1709 3.34e-46 166.0 COG2271@1|root,COG2271@2|Bacteria,1QUF4@1224|Proteobacteria,1RPSF@1236|Gammaproteobacteria,1WWNP@135613|Chromatiales 135613|Chromatiales G PFAM Major Facilitator Superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_580392_1 227377.CBU_1286 1.57e-120 361.0 COG1373@1|root,COG1373@2|Bacteria 2|Bacteria V ATPase (AAA superfamily - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_873767_1 439235.Dalk_2279 1.08e-43 162.0 COG1033@1|root,COG4191@1|root,COG1033@2|Bacteria,COG4191@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales 28221|Deltaproteobacteria K MMPL family - - - ko:K07003 - - - - ko00000 - - - GGDEF,LolA_like,MMPL,cNMP_binding k59_906942_1 1123400.KB904758_gene2390 2.77e-41 146.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,45ZQ9@72273|Thiotrichales 72273|Thiotrichales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1005500_1 631362.Thi970DRAFT_04432 6.53e-115 343.0 COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales 135613|Chromatiales P Sodium/hydrogen exchanger family - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_972283_2 1384066.JAGT01000001_gene2575 1.06e-05 51.2 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - ko:K15045 ko05164,map05164 - - - ko00000,ko00001 - - - Fer4_12,Fer4_14,Radical_SAM k59_253172_1 1123401.JHYQ01000032_gene3429 4.51e-73 230.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,1RRCR@1236|Gammaproteobacteria 1236|Gammaproteobacteria K adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins - - - - - - - - - - - - Fic k59_156591_2 1168034.FH5T_10835 6.69e-103 300.0 COG0634@1|root,COG0634@2|Bacteria,4NNIB@976|Bacteroidetes,2FN5J@200643|Bacteroidia 976|Bacteroidetes F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_156591_3 1089547.KB913013_gene2923 5.3e-42 144.0 COG0563@1|root,COG0563@2|Bacteria,4NG7J@976|Bacteroidetes,47NHN@768503|Cytophagia 976|Bacteroidetes F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,Pribosyltran k59_776217_2 765914.ThisiDRAFT_0027 1.21e-42 142.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_516691_2 1123060.JONP01000007_gene5107 1.92e-43 154.0 COG0154@1|root,COG0154@2|Bacteria,1MUKC@1224|Proteobacteria,2TTUD@28211|Alphaproteobacteria,2JZ9R@204441|Rhodospirillales 204441|Rhodospirillales J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_548343_1 1168034.FH5T_06450 1.63e-66 212.0 28NPZ@1|root,2ZBPQ@2|Bacteria,4NN3K@976|Bacteroidetes,2FPEH@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - OMP_b-brl_2 k59_384277_1 765911.Thivi_3772 1.74e-20 91.3 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1WWN0@135613|Chromatiales 135613|Chromatiales L TIGRFAM Phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_874398_2 504487.JCM19302_1733 1.48e-36 130.0 COG2391@1|root,COG2391@2|Bacteria,4NMK0@976|Bacteroidetes,1I1SD@117743|Flavobacteriia 976|Bacteroidetes S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_1037872_1 1167006.UWK_02788 1.5e-153 451.0 COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,2MJD2@213118|Desulfobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_318084_1 1121935.AQXX01000086_gene5260 1.04e-84 259.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria,1XHQ1@135619|Oceanospirillales 135619|Oceanospirillales S NAD(P)-dependent - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_907440_1 1537917.JU82_01305 1.67e-11 63.5 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2YNXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_907440_2 929558.SMGD1_2868 3.74e-35 132.0 COG0683@1|root,COG0683@2|Bacteria,1Q7JN@1224|Proteobacteria,42NDA@68525|delta/epsilon subdivisions,2YN6T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E leucine binding - - - - - - - - - - - - - k59_549128_1 96561.Dole_2063 5.09e-41 149.0 COG1145@1|root,COG1145@2|Bacteria,1QW1N@1224|Proteobacteria,42YYY@68525|delta/epsilon subdivisions,2WUE0@28221|Deltaproteobacteria,2MN7Z@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Fer4 k59_90746_1 32057.KB217478_gene3668 7.04e-21 93.2 COG0092@1|root,COG0092@2|Bacteria,1G01D@1117|Cyanobacteria,1HIYC@1161|Nostocales 1117|Cyanobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rps3 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_90746_2 380749.HY04AAS1_0270 6.88e-14 68.9 COG0091@1|root,COG0091@2|Bacteria 2|Bacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_253741_1 1168034.FH5T_08905 4.24e-187 531.0 COG0056@1|root,COG0056@2|Bacteria,4NFZW@976|Bacteroidetes,2FM4H@200643|Bacteroidia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_253741_2 1168034.FH5T_08910 1.88e-07 50.8 COG0712@1|root,COG0712@2|Bacteria,4NSNF@976|Bacteroidetes,2FQZ5@200643|Bacteroidia 976|Bacteroidetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_284752_1 1168034.FH5T_11885 4.46e-37 139.0 COG0768@1|root,COG0768@2|Bacteria,4NERV@976|Bacteroidetes,2FM0U@200643|Bacteroidia 976|Bacteroidetes M Penicillin-binding protein, transpeptidase domain protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_284752_2 927658.AJUM01000040_gene921 2.62e-06 50.1 2E4WB@1|root,32ZQF@2|Bacteria,4NUMY@976|Bacteroidetes,2FSKJ@200643|Bacteroidia,3XK5R@558415|Marinilabiliaceae 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_284752_3 999419.HMPREF1077_01962 3.28e-36 130.0 COG0275@1|root,COG0275@2|Bacteria,4NFQB@976|Bacteroidetes,2FMPT@200643|Bacteroidia,22W13@171551|Porphyromonadaceae 976|Bacteroidetes J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_646859_1 519989.ECTPHS_00475 6.92e-42 141.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1WYD2@135613|Chromatiales 135613|Chromatiales J binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_972803_1 207954.MED92_00475 1.01e-92 293.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XHJY@135619|Oceanospirillales 135619|Oceanospirillales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_549130_1 933262.AXAM01000068_gene2762 5.15e-15 76.6 COG0438@1|root,COG0438@2|Bacteria,1MVB4@1224|Proteobacteria,42TB1@68525|delta/epsilon subdivisions,2WRAQ@28221|Deltaproteobacteria,2MP1I@213118|Desulfobacterales 28221|Deltaproteobacteria M Glycosyltransferase Family 4 - - 2.4.1.348 ko:K12995 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_549130_2 768671.ThimaDRAFT_1471 6.2e-58 189.0 COG0463@1|root,COG0463@2|Bacteria,1QW3P@1224|Proteobacteria,1TJ5J@1236|Gammaproteobacteria,1WXZC@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glycos_transf_2 k59_874411_1 5693.XP_809632.1 1.66e-14 73.9 COG0319@1|root,2QUN8@2759|Eukaryota,3XUYF@5653|Kinetoplastida 5653|Kinetoplastida G Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - Hydrolase_3 k59_874411_2 411461.DORFOR_01429 1.34e-17 84.7 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,27V10@189330|Dorea 186801|Clostridia H Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_940764_1 1121405.dsmv_1974 7.8e-60 205.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MHRJ@213118|Desulfobacterales 28221|Deltaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin poR - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_811220_1 247634.GPB2148_943 1.16e-49 165.0 COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,1J6CJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S s cog2930 CT2216 - - - - - - - - - - - Ysc84 k59_486462_1 879212.DespoDRAFT_02818 1.9e-32 124.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42N47@68525|delta/epsilon subdivisions,2WIKZ@28221|Deltaproteobacteria,2MIEN@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD qrcD - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_486462_2 1121405.dsmv_1075 1.83e-22 87.4 2EJCZ@1|root,33D3Z@2|Bacteria,1NJIM@1224|Proteobacteria,42XMC@68525|delta/epsilon subdivisions,2WSWU@28221|Deltaproteobacteria,2MMDZ@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_194846_1 765911.Thivi_3617 4.35e-40 139.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1WWQJ@135613|Chromatiales 135613|Chromatiales H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_194846_2 1049564.TevJSym_as00200 3.21e-237 662.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1J4RZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - iSDY_1059.SDY_4251 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_194846_3 765910.MARPU_12625 3.93e-18 84.7 2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1S5Q0@1236|Gammaproteobacteria,1WY9R@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_194846_4 998674.ATTE01000001_gene215 1.63e-112 340.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,4600Z@72273|Thiotrichales 72273|Thiotrichales J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_194846_6 631362.Thi970DRAFT_04192 4.51e-310 862.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales 135613|Chromatiales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_194846_7 1049564.TevJSym_aj00720 6.77e-189 532.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1J5CA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroG GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_0684,iECSF_1327.ECSF_0680,iEcSMS35_1347.EcSMS35_0777,iLF82_1304.LF82_0146,iNRG857_1313.NRG857_03335,iYL1228.KPN_00758 DAHP_synth_1 k59_194846_8 1049564.TevJSym_ac01530 2.72e-21 90.9 COG0790@1|root,COG0790@2|Bacteria,1PDUX@1224|Proteobacteria,1RW86@1236|Gammaproteobacteria,1JBN1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sel1-like repeats. - - - - - - - - - - - - Sel1 k59_194846_9 223283.PSPTO_3522 1.58e-115 368.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1Z4YA@136849|Pseudomonas syringae group 1236|Gammaproteobacteria M Soluble lytic murein transglycosylase slt GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 iETEC_1333.ETEC_4747,iPC815.YPO0452 SLT,SLT_L k59_194846_10 1049564.TevJSym_ac01560 1.63e-184 555.0 COG2114@1|root,COG2114@2|Bacteria,1NQPW@1224|Proteobacteria 1224|Proteobacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - - k59_194846_11 1049564.TevJSym_ac01570 7.47e-50 163.0 COG3160@1|root,COG3160@2|Bacteria 2|Bacteria K Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase rsd GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - ko:K07740 - - - - ko00000 - - - Rsd_AlgQ k59_194846_12 765912.Thimo_0566 3.52e-86 265.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1WWMK@135613|Chromatiales 135613|Chromatiales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_194846_13 1453501.JELR01000002_gene1271 4.21e-73 239.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,1S0UK@1236|Gammaproteobacteria,46ACH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_978446_1 1121106.JQKB01000015_gene5767 8.28e-74 233.0 2DB8Q@1|root,2Z7SF@2|Bacteria,1MXSW@1224|Proteobacteria,2U0VT@28211|Alphaproteobacteria,2JQ1H@204441|Rhodospirillales 204441|Rhodospirillales C The reaction center of purple bacteria contains a tightly bound cytochrome molecule which re-reduces the photo oxidized primary electron donor pufC - - ko:K13992 - - - - ko00000,ko00194 - - - CytoC_RC k59_879878_1 96561.Dole_3184 2.88e-157 462.0 COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MIRV@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit - - 2.3.1.169 ko:K14138 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00377 R08433,R10243 RC00004,RC00113,RC01144,RC02963,RC02964,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhC k59_811876_1 326298.Suden_0898 2.59e-33 129.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2YMEZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thiol disulfide interchange protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7 k59_879879_1 1168034.FH5T_08750 1.54e-111 334.0 COG0008@1|root,COG0008@2|Bacteria,4NEED@976|Bacteroidetes,2FN2D@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_25715_1 314278.NB231_11634 1.36e-33 120.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_25715_2 394503.Ccel_1529 2.85e-17 80.9 COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,36EJW@31979|Clostridiaceae 186801|Clostridia J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_227800_1 572544.Ilyop_1807 2.12e-77 237.0 COG0090@1|root,COG0090@2|Bacteria,379DG@32066|Fusobacteria 32066|Fusobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_227800_2 1319815.HMPREF0202_01269 4.55e-51 162.0 COG0185@1|root,COG0185@2|Bacteria,37ADC@32066|Fusobacteria 32066|Fusobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_227800_3 572544.Ilyop_1805 4.46e-61 189.0 COG0091@1|root,COG0091@2|Bacteria,37A7K@32066|Fusobacteria 32066|Fusobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_227800_4 1319815.HMPREF0202_01271 2.23e-129 370.0 COG0092@1|root,COG0092@2|Bacteria,3785X@32066|Fusobacteria 32066|Fusobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_227800_7 1035196.HMPREF9998_00672 3.33e-32 114.0 COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,25RSK@186804|Peptostreptococcaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_227800_8 1278306.KB906913_gene962 2.76e-72 218.0 COG0093@1|root,COG0093@2|Bacteria,37A59@32066|Fusobacteria 32066|Fusobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_227800_9 1408439.JHXW01000004_gene1392 7.32e-66 201.0 COG0198@1|root,COG0198@2|Bacteria,37AIF@32066|Fusobacteria 32066|Fusobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_227800_10 469618.FVAG_02845 8.11e-108 313.0 COG0094@1|root,COG0094@2|Bacteria,378SH@32066|Fusobacteria 32066|Fusobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_227800_11 1321820.HMPREF1983_00886 1.06e-07 49.7 COG0199@1|root,COG0199@2|Bacteria,1VEF6@1239|Firmicutes,4HKK1@91061|Bacilli,3WEXR@539002|Bacillales incertae sedis 91061|Bacilli J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_391639_1 1168034.FH5T_17390 7.35e-24 97.4 COG0639@1|root,COG0639@2|Bacteria,4NIDG@976|Bacteroidetes,2FWN0@200643|Bacteroidia 976|Bacteroidetes T Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_391639_2 1134474.O59_001159 4.22e-19 89.0 COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria,1FG3B@10|Cellvibrio 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_195612_1 472759.Nhal_3802 5.91e-62 213.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales 135613|Chromatiales G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_782613_1 1121015.N789_03595 2.02e-58 196.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales 135614|Xanthomonadales P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_587077_1 1121405.dsmv_1757 6.09e-65 206.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,42N1F@68525|delta/epsilon subdivisions,2WK2V@28221|Deltaproteobacteria,2MI0R@213118|Desulfobacterales 28221|Deltaproteobacteria H PFAM Phosphomethylpyrimidine kinase thiD - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00941,ko:K14153,ko:K21219 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2909 Phos_pyr_kin,TMP-TENI,ThiP_synth k59_782622_2 121225.PHUM538000-PA 2.11e-11 67.4 COG1073@1|root,KOG4391@2759|Eukaryota,38DWX@33154|Opisthokonta,3BB4H@33208|Metazoa,3CWGB@33213|Bilateria,41VJQ@6656|Arthropoda,3SH0J@50557|Insecta,3E9ME@33342|Paraneoptera 33208|Metazoa S Serine hydrolase (FSH1) ABHD13 GO:0002084,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008474,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030163,GO:0030425,GO:0032838,GO:0032839,GO:0035601,GO:0036211,GO:0036477,GO:0042157,GO:0042159,GO:0042995,GO:0043005,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044463,GO:0044464,GO:0071704,GO:0097447,GO:0097458,GO:0098599,GO:0098732,GO:0098734,GO:0099568,GO:0120025,GO:0120038,GO:0120111,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - ko:K06889 - - - - ko00000 - - - Abhydrolase_1,FSH1,Hydrolase_4 k59_95926_1 1121459.AQXE01000012_gene2349 4.87e-22 91.3 COG2945@1|root,COG2945@2|Bacteria,1QY8I@1224|Proteobacteria,43CAB@68525|delta/epsilon subdivisions,2X7KV@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - - k59_422001_1 1479237.JMLY01000001_gene1046 4.12e-35 141.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,468GY@72275|Alteromonadaceae 1236|Gammaproteobacteria M esterase of the alpha-beta hydrolase superfamily plpD - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_847324_1 314285.KT71_03017 5.71e-50 178.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT6@1236|Gammaproteobacteria,1J7Y7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_912862_1 1150621.SMUL_1093 2.22e-18 89.7 COG1195@1|root,COG1361@1|root,COG3210@1|root,COG1195@2|Bacteria,COG1361@2|Bacteria,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,43DGB@68525|delta/epsilon subdivisions,2YTII@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LU Calx-beta domain - - - - - - - - - - - - Calx-beta k59_685816_1 742817.HMPREF9449_00129 6.36e-30 117.0 COG3104@1|root,COG3104@2|Bacteria,4NIIT@976|Bacteroidetes,2FMR3@200643|Bacteroidia,22X2C@171551|Porphyromonadaceae 976|Bacteroidetes E POT family dtpD - - - - - - - - - - - MFS_1,PTR2 k59_195636_1 56110.Oscil6304_3505 3.26e-99 327.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria,1H9JF@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Conserved region in glutamate synthase gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.7.1 ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 - R00021,R10086 RC00006,RC00010 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_391649_1 997346.HMPREF9374_2225 3.17e-55 186.0 COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H9R3@91061|Bacilli,27BKM@186824|Thermoactinomycetaceae 91061|Bacilli G Phosphoglycerate kinase pgk GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSB619.SA_RS04145 PGK k59_847336_1 765913.ThidrDRAFT_2215 3.85e-78 243.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,1WVWJ@135613|Chromatiales 135613|Chromatiales E ABC transporter, urea - - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_422020_1 471853.Bcav_2830 1.31e-40 140.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - - - - - - - - - - - DUF2505 k59_912873_2 472759.Nhal_2115 1.51e-56 182.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_227830_1 1167006.UWK_03444 2.2e-26 110.0 COG2197@1|root,COG3852@1|root,COG2197@2|Bacteria,COG3852@2|Bacteria,1R2HI@1224|Proteobacteria,42ZPI@68525|delta/epsilon subdivisions,2WUU1@28221|Deltaproteobacteria,2MPPT@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,PAS_4,Response_reg k59_1011529_1 3880.AES88228 5.34e-24 100.0 COG0052@1|root,COG0356@1|root,COG0636@1|root,KOG0232@2759|Eukaryota,KOG0832@2759|Eukaryota,KOG4665@2759|Eukaryota,37S1B@33090|Viridiplantae,3GHIA@35493|Streptophyta 35493|Streptophyta J ribosomal protein S2 rps2 GO:0000313,GO:0000314,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0031974,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0098798,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_25759_1 96561.Dole_1325 3.58e-51 164.0 2AJQY@1|root,31ACW@2|Bacteria,1Q5CW@1224|Proteobacteria,4311R@68525|delta/epsilon subdivisions,2WWI4@28221|Deltaproteobacteria,2MP0K@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_25759_2 96561.Dole_1326 2.49e-25 103.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,42NVI@68525|delta/epsilon subdivisions,2WJTD@28221|Deltaproteobacteria,2MMNF@213118|Desulfobacterales 28221|Deltaproteobacteria EH PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1011533_1 1123228.AUIH01000042_gene2992 6.24e-24 97.4 COG0671@1|root,COG0671@2|Bacteria,1RIRR@1224|Proteobacteria,1T0AG@1236|Gammaproteobacteria 1236|Gammaproteobacteria I phosphoesterase, PA-phosphatase - - - - - - - - - - - - PAP2 k59_1011533_2 1123517.JOMR01000001_gene699 8.27e-14 72.8 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,46225@72273|Thiotrichales 72273|Thiotrichales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_195667_1 477974.Daud_0138 3.01e-23 103.0 COG2199@1|root,COG2206@1|root,COG3290@1|root,COG3829@1|root,COG4936@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,COG4936@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia,267B5@186807|Peptococcaceae 186801|Clostridia T PAS domain - - - - - - - - - - - - GGDEF,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9 k59_782660_1 933262.AXAM01000018_gene968 1.51e-27 116.0 COG4972@1|root,COG4972@2|Bacteria,1RCKF@1224|Proteobacteria,42R0T@68525|delta/epsilon subdivisions,2WMSI@28221|Deltaproteobacteria,2MKAH@213118|Desulfobacterales 28221|Deltaproteobacteria NU Pilus assembly protein - - - - - - - - - - - - PilM_2 k59_195672_1 768671.ThimaDRAFT_1999 1.83e-24 95.5 2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria,1WYYH@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_290499_1 1207063.P24_08986 3.91e-41 141.0 COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,2JTMR@204441|Rhodospirillales 204441|Rhodospirillales T TspO/MBR family - - - ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 - - - ko00000,ko00001,ko02000 9.A.24 - - TspO_MBR k59_358684_2 1168034.FH5T_12340 7.57e-224 629.0 28HQ3@1|root,2Z7XW@2|Bacteria,4NF9H@976|Bacteroidetes,2FPMP@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF2851 k59_129272_2 405948.SACE_5073 2.92e-250 696.0 COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4E9CU@85010|Pseudonocardiales 201174|Actinobacteria L Transposase tnp3508a - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_129272_3 1449347.JQLN01000006_gene2545 4.1e-44 154.0 COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,2M60B@2063|Kitasatospora 201174|Actinobacteria L Integrase core domain - - - ko:K07483 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_259396_1 1041147.AUFB01000014_gene231 1.32e-102 316.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_748163_1 1123228.AUIH01000059_gene3722 7.28e-64 210.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1XH48@135619|Oceanospirillales 135619|Oceanospirillales E acetylornithine aminotransferase argD - 2.6.1.11,2.6.1.17,2.6.1.81 ko:K00821,ko:K00840 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04217,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1043829_1 177437.HRM2_46360 1.11e-171 498.0 COG2801@1|root,COG2801@2|Bacteria,1RCQN@1224|Proteobacteria,42R94@68525|delta/epsilon subdivisions,2WN3K@28221|Deltaproteobacteria,2MJKF@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - - k59_129290_1 1120999.JONM01000007_gene1726 2.53e-29 120.0 2B3X8@1|root,31WM6@2|Bacteria,1RFRT@1224|Proteobacteria,2VRRY@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3999) - - - - - - - - - - - - DUF3999 k59_323344_1 395493.BegalDRAFT_0706 1.23e-08 60.1 COG3210@1|root,COG3210@2|Bacteria,1QMZZ@1224|Proteobacteria,1SG2Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria U TIGRFAM filamentous hemagglutinin family N-terminal domain - - - - - - - - - - - - Haemagg_act k59_61842_1 1265313.HRUBRA_01474 1.32e-131 386.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,1RS1U@1236|Gammaproteobacteria 1236|Gammaproteobacteria K acetyltransferase yghO GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - - k59_1043832_1 1049564.TevJSym_aa01890 2.38e-115 346.0 COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_978539_1 572544.Ilyop_1203 9.78e-147 421.0 COG0192@1|root,COG0192@2|Bacteria,379HD@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_391701_1 1168034.FH5T_16560 2.24e-251 717.0 COG3533@1|root,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes,2FRIG@200643|Bacteroidia 976|Bacteroidetes S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Big_4,DUF4986,Glyco_hydro_127,Laminin_G_3 k59_259399_1 1216362.B437_01670 1.24e-14 72.8 COG0515@1|root,COG0515@2|Bacteria,37A1Q@32066|Fusobacteria 32066|Fusobacteria KLT serine threonine protein kinase - - - ko:K02850 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005 - - - RIO1,WaaY k59_259399_2 572544.Ilyop_1196 1.33e-274 769.0 COG0726@1|root,COG1819@1|root,COG0726@2|Bacteria,COG1819@2|Bacteria,379I2@32066|Fusobacteria 32066|Fusobacteria G Glycosyl transferase 4-like - - - - - - - - - - - - Glyco_transf_4,Polysacc_deac_1 k59_879948_1 1122134.KB893650_gene271 1.54e-72 229.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1XHUW@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_422067_1 1254432.SCE1572_36940 7.29e-34 137.0 COG0695@1|root,COG0695@2|Bacteria,1QVSK@1224|Proteobacteria,43DC6@68525|delta/epsilon subdivisions,2X8I6@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM glutaredoxin - - - - - - - - - - - - - k59_259400_2 557598.LHK_03005 7.97e-33 120.0 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,2KR00@206351|Neisseriales 206351|Neisseriales C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_717146_1 1168034.FH5T_05545 1.49e-47 160.0 COG0053@1|root,COG0053@2|Bacteria,4NEID@976|Bacteroidetes,2FNNF@200643|Bacteroidia 976|Bacteroidetes P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_717146_2 1168034.FH5T_05540 3.2e-24 97.4 COG3279@1|root,COG3279@2|Bacteria,4NF8U@976|Bacteroidetes,2FMI5@200643|Bacteroidia 976|Bacteroidetes KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_25796_1 1123368.AUIS01000001_gene2024 7.66e-21 94.7 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,2NC0C@225057|Acidithiobacillales 225057|Acidithiobacillales S M61 glycyl aminopeptidase - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_25796_2 1005395.CSV86_20532 7.57e-32 122.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_391703_1 34506.g3028 1.05e-13 71.6 2EGUQ@1|root,2SMPF@2759|Eukaryota,3ADXV@33154|Opisthokonta,3BZA8@33208|Metazoa,3DFB0@33213|Bilateria 33208|Metazoa S Sigma-70 region 2 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4 k59_391703_2 1144275.COCOR_01453 8.87e-48 164.0 COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,42ND0@68525|delta/epsilon subdivisions,2WNKU@28221|Deltaproteobacteria,2YTTK@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF808) - - - ko:K09781 - - - - ko00000 - - - DUF808 k59_323352_1 875454.BAEW01000004_gene846 1.06e-07 57.0 COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes,24AB7@186801|Clostridia 186801|Clostridia M PFAM O-antigen polymerase - - - - - - - - - - - - Wzy_C k59_323352_2 469616.FMAG_00659 6.77e-10 59.7 COG0859@1|root,COG0859@2|Bacteria,378J9@32066|Fusobacteria 32066|Fusobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1011580_1 243233.MCA3076 7.82e-52 178.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1XEHX@135618|Methylococcales 135618|Methylococcales N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_96008_1 1537917.JU82_09485 2.42e-62 202.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2YMUV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_96008_2 709032.Sulku_0210 6.54e-120 347.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2YM98@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_331241_1 888050.HMPREF9004_0568 5.72e-26 102.0 COG0212@1|root,COG0212@2|Bacteria,2IKWR@201174|Actinobacteria,4D33A@85005|Actinomycetales 201174|Actinobacteria H 5-formyltetrahydrofolate cyclo-ligase ygfA - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_331241_2 1304865.JAGF01000001_gene385 1.32e-30 122.0 COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4F0SH@85016|Cellulomonadaceae 201174|Actinobacteria S PFAM peptidase S45 penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_199954_1 1286632.P278_09840 8.8e-95 293.0 COG1621@1|root,COG1621@2|Bacteria,4NGJC@976|Bacteroidetes,1I15I@117743|Flavobacteriia 976|Bacteroidetes G Pkd domain containing protein - - - - - - - - - - - - - k59_755470_1 1150621.SMUL_1560 7.22e-148 420.0 COG2875@1|root,COG2875@2|Bacteria,1MVYY@1224|Proteobacteria,42P88@68525|delta/epsilon subdivisions 1224|Proteobacteria H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase cobM - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase k59_428605_1 387093.SUN_0583 2.83e-76 249.0 COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2YNBS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,ResIII k59_755471_1 1121405.dsmv_1332 5.31e-80 251.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2MHQX@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_8 k59_102400_1 1168034.FH5T_07145 1.44e-40 141.0 COG2825@1|root,COG2825@2|Bacteria 2|Bacteria M unfolded protein binding ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_232927_1 1144310.PMI07_004125 3.11e-40 142.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2U1VY@28211|Alphaproteobacteria,4BA76@82115|Rhizobiaceae 28211|Alphaproteobacteria NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR2 - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_167985_2 1249627.D779_3323 2.25e-52 183.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales 135613|Chromatiales P PFAM Na Picotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_919753_2 632292.Calhy_0247 6.84e-143 445.0 COG0421@1|root,COG0421@2|Bacteria,1VRGK@1239|Firmicutes,24C37@186801|Clostridia 186801|Clostridia E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth k59_919753_3 891974.E05_46600 6.63e-26 110.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,282JA@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_919753_4 1123296.JQKE01000018_gene1585 3.92e-06 49.3 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,2KPI0@206351|Neisseriales 206351|Neisseriales P Psort location CytoplasmicMembrane, score - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_363606_2 641149.HMPREF9016_02171 1.5e-26 99.8 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2VVTR@28216|Betaproteobacteria,2KS03@206351|Neisseriales 206351|Neisseriales S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_363606_3 861299.J421_1069 1.84e-16 75.5 COG0594@1|root,COG0594@2|Bacteria,1ZV89@142182|Gemmatimonadetes 142182|Gemmatimonadetes J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_494587_1 1535422.ND16A_3571 3.29e-78 243.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q707@267889|Colwelliaceae 1236|Gammaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_462159_2 1187848.AJYQ01000003_gene410 5.74e-92 285.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_494589_1 1417296.U879_08090 4.54e-52 172.0 COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,2U3QM@28211|Alphaproteobacteria 28211|Alphaproteobacteria C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4_9 k59_658298_1 768671.ThimaDRAFT_0847 5.4e-78 251.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SA31@1236|Gammaproteobacteria 1224|Proteobacteria T SMART ATP-binding region, ATPase-like - - - - - - - - - - - - HATPase_c,HisKA,PAS_3 k59_69306_2 1379270.AUXF01000003_gene3534 2.66e-113 341.0 COG1008@1|root,COG1008@2|Bacteria,1ZUBB@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Proton-conducting membrane transporter - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_821263_1 1168034.FH5T_12300 8.02e-104 308.0 COG2334@1|root,COG2334@2|Bacteria,4NITA@976|Bacteroidetes 976|Bacteroidetes S A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - - - - - - - - - - - k59_167995_1 331636.G5O_0916 7.35e-28 117.0 COG1197@1|root,COG1197@2|Bacteria,2JFGI@204428|Chlamydiae 204428|Chlamydiae L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_167995_2 1120980.JQKH01000002_gene272 2.63e-06 49.3 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,2KPNM@206351|Neisseriales 206351|Neisseriales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_952018_1 360107.CHAB381_1436 6.72e-17 85.9 2AJBX@1|root,319X7@2|Bacteria,1Q4BG@1224|Proteobacteria,42YT4@68525|delta/epsilon subdivisions,2YRDM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_331256_1 211586.SO_0859 1.09e-89 319.0 COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3852@1|root,COG4251@1|root,COG5000@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG3852@2|Bacteria,COG4251@2|Bacteria,COG5000@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_690492_1 99598.Cal7507_5009 2.43e-25 106.0 COG1509@1|root,COG1509@2|Bacteria,1G4BY@1117|Cyanobacteria,1HQUC@1161|Nostocales 1117|Cyanobacteria C Lysine-2,3-aminomutase - - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_2771_1 484770.UFO1_3152 1.09e-95 286.0 COG1082@1|root,COG1082@2|Bacteria,1UZXE@1239|Firmicutes,4H2VV@909932|Negativicutes 909932|Negativicutes G PFAM Xylose isomerase domain-containing protein TIM barrel - - - ko:K06605 - - - - ko00000 - - - AP_endonuc_2 k59_2771_2 338963.Pcar_0912 2.34e-103 304.0 COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1R71B@1224|Proteobacteria,42SBN@68525|delta/epsilon subdivisions,2WP4A@28221|Deltaproteobacteria,43VBX@69541|Desulfuromonadales 28221|Deltaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20,HTH_5,Rhodanese k59_2771_3 338963.Pcar_0913 8.68e-81 243.0 COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,43B7P@68525|delta/epsilon subdivisions,2X6M4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K05586 ko00190,ko01100,map00190,map01100 - R11945 RC00061 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx k59_2771_4 338963.Pcar_0914 5.66e-71 231.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.12.1.3,1.6.5.2,1.6.5.3 ko:K00124,ko:K00335,ko:K00355,ko:K18331 ko00130,ko00190,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,ko05200,ko05225,ko05418,map00130,map00190,map00630,map00680,map01100,map01110,map01120,map01200,map05200,map05225,map05418 M00144 R00519,R02964,R03643,R03816,R11945 RC00061,RC00819,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_984550_1 1046714.AMRX01000003_gene491 2.35e-16 75.1 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,467H1@72275|Alteromonadaceae 1236|Gammaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520 PgpA k59_984550_2 1163617.SCD_n02191 3.46e-12 67.8 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria 28216|Betaproteobacteria S Aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_723124_1 1168289.AJKI01000010_gene1594 2.9e-40 152.0 COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FM4Z@200643|Bacteroidia,3XJ3T@558415|Marinilabiliaceae 976|Bacteroidetes G Domain of unknown function (DUF5110) - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31 k59_363629_1 1121904.ARBP01000009_gene4310 5.64e-93 280.0 COG3301@1|root,COG3301@2|Bacteria,4NITJ@976|Bacteroidetes 976|Bacteroidetes P Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_428631_1 631362.Thi970DRAFT_02913 3.1e-35 127.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1WY7U@135613|Chromatiales 135613|Chromatiales J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_690502_1 1121396.KB893081_gene1734 4.42e-41 146.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MIR1@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_690502_2 879212.DespoDRAFT_02270 2.33e-48 163.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,42P86@68525|delta/epsilon subdivisions,2WN8T@28221|Deltaproteobacteria,2MJWP@213118|Desulfobacterales 28221|Deltaproteobacteria M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_886153_1 1168034.FH5T_04780 7.58e-139 400.0 COG0436@1|root,COG0436@2|Bacteria,4NG6G@976|Bacteroidetes,2FN1B@200643|Bacteroidia 976|Bacteroidetes E Aminotransferase, class I II aspC - 2.6.1.1,2.6.1.2,2.6.1.66 ko:K00812,ko:K14260 ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R05052 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_363630_1 1249480.B649_08920 2.64e-105 313.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2YMSY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Co-chaperone-curved DNA binding protein A cbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_592008_1 2340.JV46_08070 2.79e-75 239.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1J54W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - iZ_1308.Z4900 Pyr_redox_2,Pyr_redox_dim k59_723126_1 298386.PBPRA1404 4.74e-111 335.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XUVI@135623|Vibrionales 135623|Vibrionales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_723126_2 216142.LT40_20180 3.43e-13 70.5 COG3637@1|root,COG3637@2|Bacteria,1RJJS@1224|Proteobacteria,1SET5@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - ko:K12976 - - - - ko00000,ko01000,ko01005 - - - PagL k59_690503_1 1168034.FH5T_18275 9.89e-25 101.0 COG0111@1|root,COG0111@2|Bacteria,4NGEB@976|Bacteroidetes,2FMMV@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate pdxB - 1.1.1.290 ko:K03473 ko00750,ko01100,map00750,map01100 M00124 R04210 RC00084 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C,DUF3410 k59_690503_2 1168034.FH5T_18270 4.95e-203 571.0 COG0362@1|root,COG0362@2|Bacteria,4NG05@976|Bacteroidetes,2FMFW@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_984560_1 1122599.AUGR01000002_gene3344 1.26e-49 174.0 COG3069@1|root,COG3069@2|Bacteria,1R2JV@1224|Proteobacteria,1T5RB@1236|Gammaproteobacteria,1XS18@135619|Oceanospirillales 135619|Oceanospirillales C C4-dicarboxylate transmembrane transporter activity - - - - - - - - - - - - - k59_984560_2 1415630.U771_28390 3.92e-07 54.3 COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,1S0R2@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_102449_1 749222.Nitsa_0020 5.17e-50 169.0 COG0388@1|root,COG0388@2|Bacteria,1PZZZ@1224|Proteobacteria,42REP@68525|delta/epsilon subdivisions,2YP77@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - CN_hydrolase k59_102449_2 387093.SUN_2400 9.64e-47 156.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2YNXJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H protein-L-isoaspartate O-methyltransferase pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_462859_6 572544.Ilyop_1438 2.96e-141 406.0 COG0142@1|root,COG0142@2|Bacteria,3787Y@32066|Fusobacteria 32066|Fusobacteria H Belongs to the FPP GGPP synthase family - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_462859_7 572544.Ilyop_1439 1.19e-10 57.4 COG1722@1|root,COG1722@2|Bacteria,37AZJ@32066|Fusobacteria 32066|Fusobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_658900_1 36874.HQ34_08525 5.27e-21 90.1 COG0084@1|root,COG0084@2|Bacteria,4NEVW@976|Bacteroidetes,2FMP9@200643|Bacteroidia,22XKP@171551|Porphyromonadaceae 976|Bacteroidetes L hydrolase, TatD tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_658900_2 385682.AFSL01000006_gene2377 3.74e-31 119.0 COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,2FM43@200643|Bacteroidia,3XJIK@558415|Marinilabiliaceae 976|Bacteroidetes E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase gdhA - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_592566_1 192952.MM_1819 1.41e-116 355.0 arCOG04931@1|root,arCOG04931@2157|Archaea,2XZHF@28890|Euryarchaeota 28890|Euryarchaeota - - - - - - - - - - - - - - - k59_854575_1 639282.DEFDS_2021 2.16e-72 233.0 COG1373@1|root,COG1373@2|Bacteria,2GFZK@200930|Deferribacteres 200930|Deferribacteres S Domain of unknown function (DUF4143) - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_69897_1 426114.THI_0137 3.33e-29 120.0 28IUD@1|root,2Z8T4@2|Bacteria,1QZHS@1224|Proteobacteria,2VK06@28216|Betaproteobacteria 28216|Betaproteobacteria S Carboxysome shell peptide mid-region - - - - - - - - - - - - CsoS2_M k59_789062_2 269796.Rru_A0481 1.65e-144 439.0 COG1752@1|root,COG1752@2|Bacteria,1N5JZ@1224|Proteobacteria,2UENP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - - k59_1017949_1 373994.Riv7116_2921 4.53e-15 76.3 COG2197@1|root,COG2197@2|Bacteria,1G33W@1117|Cyanobacteria,1HR5P@1161|Nostocales 1117|Cyanobacteria K PFAM Response regulator receiver domain - - - - - - - - - - - - GerE,Response_reg k59_821950_1 498761.HM1_1002 1.44e-27 111.0 COG1643@1|root,COG1643@2|Bacteria,1TPET@1239|Firmicutes,250IE@186801|Clostridia 186801|Clostridia L Helicase associated domain (HA2) Add an annotation - - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - HA2,Helicase_C k59_821950_2 565045.NOR51B_1193 2.99e-40 145.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system, permease component VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_103129_1 322710.Avin_19830 3.54e-111 339.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5 k59_135890_1 1168034.FH5T_05690 9.45e-110 353.0 COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,2FMIV@200643|Bacteroidia 976|Bacteroidetes S Peptidase family C25 porU - - - - - - - - - - - Peptidase_C25 k59_265729_1 1168034.FH5T_17370 5.45e-89 270.0 COG1609@1|root,COG1609@2|Bacteria,4NFB7@976|Bacteroidetes,2FQD2@200643|Bacteroidia 976|Bacteroidetes K Bacterial regulatory proteins, gntR family - - - - - - - - - - - - GntR,Peripla_BP_3 k59_723648_2 469618.FVAG_01471 1.8e-116 345.0 COG1940@1|root,COG1940@2|Bacteria,378B8@32066|Fusobacteria 32066|Fusobacteria GK Psort location Cytoplasmic, score 9.97 - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_723648_3 1484479.DI14_06390 4.25e-59 195.0 COG3568@1|root,COG3568@2|Bacteria,1TQZG@1239|Firmicutes,4HGS5@91061|Bacilli,3WERD@539002|Bacillales incertae sedis 91061|Bacilli L Endonuclease/Exonuclease/phosphatase family rgfB - 3.1.3.90 ko:K06896 ko00500,map00500 - R10486 RC00017 ko00000,ko00001,ko01000 - - - Exo_endo_phos k59_723648_4 642492.Clole_0765 1.1e-160 476.0 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1TPJ8@1239|Firmicutes,24809@186801|Clostridia 186801|Clostridia G pts system - - 2.7.1.208 ko:K20107,ko:K20108 ko00500,ko02060,map00500,map02060 M00806 R04111 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.11,4.A.1.1.12 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_723648_5 1391647.AVSV01000020_gene2194 8.79e-267 744.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,36DTW@31979|Clostridiaceae 186801|Clostridia G PFAM alpha amylase, catalytic gsj - 3.2.1.1,3.2.1.20 ko:K01176,ko:K01187 ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973 - R00028,R00801,R00802,R02108,R02112,R06087,R06088,R11262 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH13,GH31 - Alpha-amylase,DUF3459,Malt_amylase_C k59_265733_2 1049564.TevJSym_ap00600 3.14e-66 208.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_821972_1 1185876.BN8_03493 8.41e-85 259.0 COG3507@1|root,COG3507@2|Bacteria,4NEIZ@976|Bacteroidetes,47NFQ@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 k59_821972_2 1123008.KB905697_gene3333 1.37e-07 52.8 COG3250@1|root,COG3250@2|Bacteria,4NFPC@976|Bacteroidetes,2FPUZ@200643|Bacteroidia,22WX3@171551|Porphyromonadaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_789089_1 261292.Nit79A3_2014 1.34e-19 90.5 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,372HQ@32003|Nitrosomonadales 28216|Betaproteobacteria O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_886656_1 631362.Thi970DRAFT_02764 8.34e-49 165.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1WYDI@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome c, class I - - - - - - - - - - - - Cytochrom_C k59_3179_1 697282.Mettu_0898 6.45e-20 83.2 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1XFHQ@135618|Methylococcales 135618|Methylococcales O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_3179_2 243233.MCA1817 3.17e-34 122.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1XFF5@135618|Methylococcales 135618|Methylococcales J Belongs to the HSP15 family hslR - - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_298505_1 387093.SUN_2227 2.47e-36 135.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2YM9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase - - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 k59_298505_2 387093.SUN_2226 3.99e-67 223.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4_10,Molybdopterin,NADH-G_4Fe-4S_3 k59_364309_1 1278073.MYSTI_07662 1.12e-89 270.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2YW96@29|Myxococcales 28221|Deltaproteobacteria K Transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_592599_1 572544.Ilyop_1549 1.93e-115 349.0 COG1032@1|root,COG1032@2|Bacteria,378ST@32066|Fusobacteria 32066|Fusobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_592599_2 394503.Ccel_2567 1.73e-217 604.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,36H3S@31979|Clostridiaceae 186801|Clostridia C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73 ko:K00052,ko:K07246 ko00290,ko00630,ko00650,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00630,map00650,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00215,R00994,R01751,R02545,R04426,R06180,R10052 RC00084,RC00105,RC00417,RC00594,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_528117_1 1485544.JQKP01000004_gene457 2e-105 314.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,44V0R@713636|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_920442_1 237368.SCABRO_01129 1.81e-180 508.0 COG0119@1|root,COG0119@2|Bacteria 2|Bacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_920442_2 1122137.AQXF01000002_gene126 6.95e-74 223.0 COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,2U728@28211|Alphaproteobacteria 28211|Alphaproteobacteria E methylmalonyl-CoA epimerase mce - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_792254_1 1168034.FH5T_08870 6.36e-107 313.0 COG5587@1|root,COG5587@2|Bacteria,4NNS3@976|Bacteroidetes,2FPZZ@200643|Bacteroidia 976|Bacteroidetes S TIGR02453 family - - - - - - - - - - - - DUF2461 k59_401520_1 765913.ThidrDRAFT_2601 8.53e-31 115.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1WX92@135613|Chromatiales 135613|Chromatiales D probably involved in intracellular septation - - - ko:K06190 - - - - ko00000 - - - IspA k59_401520_2 1304883.KI912532_gene2018 9.68e-38 128.0 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2VUM7@28216|Betaproteobacteria,2KWK7@206389|Rhodocyclales 206389|Rhodocyclales S YCII-related domain - - - ko:K09780 - - - - ko00000 - - - YCII k59_630877_1 1209072.ALBT01000031_gene1808 8.92e-30 116.0 2BWJV@1|root,32U7J@2|Bacteria,1N47S@1224|Proteobacteria,1S8XJ@1236|Gammaproteobacteria,1FI8Q@10|Cellvibrio 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_369590_1 1108045.GORHZ_164_00300 3.4e-47 166.0 COG0530@1|root,COG0530@2|Bacteria,2GJR3@201174|Actinobacteria,4GD89@85026|Gordoniaceae 201174|Actinobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_598214_1 768671.ThimaDRAFT_4232 2.34e-89 276.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1WX1N@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_598214_2 1049564.TevJSym_aj00190 2.41e-26 104.0 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1J6KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes mutT GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - iE2348C_1286.E2348C_0104,iSDY_1059.SDY_0129 NUDIX,NUDIX_4,TMP-TENI k59_826731_1 1094508.Tsac_1341 1.67e-90 279.0 COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,248JG@186801|Clostridia,42FWB@68295|Thermoanaerobacterales 186801|Clostridia L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,HhH-GPD,Transposase_20 k59_141334_1 395493.BegalDRAFT_2421 1.01e-05 47.8 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,45ZY4@72273|Thiotrichales 72273|Thiotrichales S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_174533_1 765913.ThidrDRAFT_0973 2.43e-55 179.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,1WY50@135613|Chromatiales 135613|Chromatiales T low molecular weight - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_402440_1 572544.Ilyop_0037 2.99e-45 155.0 COG0859@1|root,COG0859@2|Bacteria,378VK@32066|Fusobacteria 32066|Fusobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 k59_402440_2 572544.Ilyop_0038 1.09e-55 181.0 COG0463@1|root,COG0463@2|Bacteria,378GA@32066|Fusobacteria 32066|Fusobacteria M Glycosyltransferase, group 2 family protein - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 k59_142343_1 1121904.ARBP01000002_gene7004 6.39e-35 137.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,4NDXY@976|Bacteroidetes,47U9U@768503|Cytophagia 976|Bacteroidetes M Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_926400_1 290400.Jann_3108 2.75e-46 162.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - MacB_PCD k59_792877_1 765911.Thivi_3897 4.76e-86 280.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1WW9S@135613|Chromatiales 135613|Chromatiales E Bacterial transglutaminase-like N-terminal - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_958042_1 387093.SUN_0013 1.59e-48 159.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,42RFN@68525|delta/epsilon subdivisions,2YP6C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_566670_1 360104.CCC13826_1780 3.05e-59 199.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2YMFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_501664_1 388919.SSA_0289 2.55e-55 196.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,1WRER@1305|Streptococcus sanguinis 91061|Bacilli J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_926406_1 880073.Calab_0946 0.000752 43.1 COG1195@1|root,COG1195@2|Bacteria,2NPEJ@2323|unclassified Bacteria 2|Bacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_926406_2 935863.AWZR01000001_gene1566 2.14e-42 150.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1X3F0@135614|Xanthomonadales 135614|Xanthomonadales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_599245_1 745411.B3C1_17797 1.44e-06 51.6 COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SWYJ@1236|Gammaproteobacteria,1J6IG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Anti sigma-E protein RseA, N-terminal domain - - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N k59_468301_1 1333507.AUTQ01000248_gene2216 3.29e-46 158.0 arCOG11972@1|root,30KBF@2|Bacteria,1N1VF@1224|Proteobacteria,1SGYU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4166) - - - - - - - - - - - - DUF4166 k59_468301_2 1034943.BN1094_02512 2.36e-57 183.0 COG5528@1|root,COG5528@2|Bacteria,1RDUE@1224|Proteobacteria,1S5XB@1236|Gammaproteobacteria,1JEB0@118969|Legionellales 118969|Legionellales S Predicted integral membrane protein (DUF2269) - - - - - - - - - - - - DUF2269 k59_468301_3 472759.Nhal_1254 3.18e-121 366.0 COG0702@1|root,COG0702@2|Bacteria,1MZ0C@1224|Proteobacteria,1S2PQ@1236|Gammaproteobacteria,1WZW0@135613|Chromatiales 135613|Chromatiales GM DoxX-like family - - - - - - - - - - - - DoxX_3,NAD_binding_10 k59_468301_5 748658.KB907321_gene848 8.02e-81 244.0 COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,1RRGB@1236|Gammaproteobacteria,1X08N@135613|Chromatiales 135613|Chromatiales K Bacterial regulatory protein, arsR family - - - - - - - - - - - - MarR_2 k59_468301_6 1049564.TevJSym_al00280 2.61e-111 329.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1J4P0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction protein - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - HDOD k59_468301_7 1049564.TevJSym_al00270 1.72e-107 325.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1J62T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S aminomethyltransferase related to GcvT ygfZ GO:0003674,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0019842,GO:0022607,GO:0031163,GO:0031406,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071840,GO:0072341,GO:0097159,GO:1901363 - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_468301_8 765911.Thivi_0897 4.45e-220 632.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,1RNZU@1236|Gammaproteobacteria,1WXEZ@135613|Chromatiales 135613|Chromatiales K PFAM Ribonuclease II - - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_468301_10 754477.Q7C_1447 1.98e-74 237.0 COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,1RSI6@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Enoyl-CoA hydratase rpfF - - ko:K13816 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001 - - - ECH_1 k59_468301_11 946483.Cenrod_2578 4.27e-79 288.0 COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2203@1|root,COG3614@1|root,COG3829@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG3614@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,4AJX3@80864|Comamonadaceae 28216|Betaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_468301_12 1049564.TevJSym_bf00050 7.19e-17 75.1 COG0236@1|root,COG0236@2|Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_468301_13 1105367.CG50_14340 1.23e-127 380.0 COG0304@1|root,COG0304@2|Bacteria,1MV30@1224|Proteobacteria,2TRYK@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family fabF1 - - ko:K14660 - - - - ko00000,ko01000 - - - Ketoacyl-synt_C,ketoacyl-synt k59_468301_14 671143.DAMO_2996 4.34e-52 196.0 COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria 2|Bacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM k59_468301_15 1123368.AUIS01000010_gene2326 5.42e-43 173.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K10715,ko:K20974 ko02020,ko02024,ko02025,map02020,map02024,map02025 M00517,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_468301_16 1049564.TevJSym_bf00090 1.82e-153 441.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1J4VQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T a CheY-like receiver domain and an HD-GYP domain rpfG - - ko:K07814,ko:K13815 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko02022 - - - HD,HD_5,Response_reg k59_468301_17 1232683.ADIMK_3644 2.18e-109 318.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,1RRRU@1236|Gammaproteobacteria,465E1@72275|Alteromonadaceae 1236|Gammaproteobacteria E phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_468301_18 572477.Alvin_1282 2.43e-172 488.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1WWPU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_665002_1 765913.ThidrDRAFT_0469 1.33e-21 95.1 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X08T@135613|Chromatiales 135613|Chromatiales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_665002_2 314230.DSM3645_26444 1.95e-15 76.3 COG0366@1|root,COG0366@2|Bacteria,2IXJN@203682|Planctomycetes 203682|Planctomycetes G alpha amylase catalytic - - 3.2.1.1,3.2.1.10,5.4.99.16 ko:K01182,ko:K05343 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00801,R01557,R01718,R01791,R02108,R02112,R06199,R11262 RC00028,RC00059,RC00077,RC00451,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459,Malt_amylase_C k59_41800_1 633131.TR2A62_2139 1.05e-26 100.0 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2UF6K@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_41800_2 1479238.JQMZ01000001_gene422 2.53e-19 81.3 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2U756@28211|Alphaproteobacteria,43Y1Q@69657|Hyphomonadaceae 28211|Alphaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_792887_1 472759.Nhal_2782 3.85e-134 409.0 COG0508@1|root,COG1249@1|root,COG0508@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding,Pyr_redox_2,Pyr_redox_dim k59_631937_1 1121948.AUAC01000007_gene330 1.64e-09 61.6 COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria,43XAS@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_631937_2 1166948.JPZL01000001_gene3250 7.73e-47 159.0 COG0220@1|root,COG0220@2|Bacteria,1RE0G@1224|Proteobacteria,1RS5R@1236|Gammaproteobacteria,1XJNJ@135619|Oceanospirillales 135619|Oceanospirillales J Methyltransferase - - - - - - - - - - - - Methyltransf_4 k59_109142_1 621372.ACIH01000181_gene2097 1.74e-19 94.7 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,26TGK@186822|Paenibacillaceae 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_207039_1 706587.Desti_5203 3.3e-135 404.0 COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,42NG1@68525|delta/epsilon subdivisions,2WM58@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Protein of unknown function (DUF3141) - - - - - - - - - - - - DUF3141 k59_174572_1 400668.Mmwyl1_3705 2.52e-67 208.0 COG3090@1|root,COG3090@2|Bacteria 2|Bacteria G Trap-type c4-dicarboxylate transport system, small permease component - - - ko:K11689,ko:K21394 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctQ k59_174572_2 400668.Mmwyl1_3704 3.34e-09 57.0 COG1638@1|root,COG1638@2|Bacteria,1MXUZ@1224|Proteobacteria,1S79Q@1236|Gammaproteobacteria,1XPVU@135619|Oceanospirillales 135619|Oceanospirillales G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_370528_1 1297742.A176_07125 6.67e-05 47.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - - k59_271019_1 469617.FUAG_01630 1.24e-58 186.0 COG1898@1|root,COG1898@2|Bacteria,379FK@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose - - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_271019_2 572544.Ilyop_0809 8.36e-11 61.2 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity - - - - - - - - - - - - Epimerase k59_271019_3 572544.Ilyop_0809 1.13e-82 253.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity - - - - - - - - - - - - Epimerase k59_402476_1 1168034.FH5T_12250 4.83e-134 392.0 COG2721@1|root,COG2721@2|Bacteria,4NFVQ@976|Bacteroidetes,2FPGJ@200643|Bacteroidia 976|Bacteroidetes G SAF domain protein uxaA - 4.2.1.42,4.2.1.7 ko:K01685,ko:K01708 ko00040,ko00053,ko01100,map00040,map00053,map01100 M00631 R01540,R05608 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_599265_1 385682.AFSL01000064_gene1700 2.98e-76 237.0 COG0501@1|root,COG0501@2|Bacteria,4NE0J@976|Bacteroidetes,2FQJ1@200643|Bacteroidia,3XJXP@558415|Marinilabiliaceae 976|Bacteroidetes O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_41813_1 56780.SYN_00875 1.44e-10 67.4 COG0745@1|root,COG2197@1|root,COG0745@2|Bacteria,COG2197@2|Bacteria,1MVNV@1224|Proteobacteria 1224|Proteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MA20_23080 - - - - - - - - - - - GerE,Response_reg k59_338538_1 1284686.HMPREF1630_06910 9.84e-35 136.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,22G6N@1570339|Peptoniphilaceae 186801|Clostridia G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C k59_501700_1 1168034.FH5T_08575 1.47e-133 409.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,2FP1Q@200643|Bacteroidia 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_566699_1 754477.Q7C_885 6.03e-145 423.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,45ZQZ@72273|Thiotrichales 72273|Thiotrichales O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - ATPase,ChlI k59_1023405_1 883096.HMPREF9699_00373 4.3e-12 65.5 COG0318@1|root,COG0318@2|Bacteria,4PKJY@976|Bacteroidetes,1IJBB@117743|Flavobacteriia 976|Bacteroidetes IQ GH3 auxin-responsive promoter - - - - - - - - - - - - GH3 k59_1023405_2 1168034.FH5T_03570 5.21e-99 291.0 COG1428@1|root,COG1428@2|Bacteria,4NFA8@976|Bacteroidetes,2FSWC@200643|Bacteroidia 976|Bacteroidetes F Deoxynucleoside kinase dck - - - - - - - - - - - dNK k59_303750_1 827.JFJK01000005_gene1214 4.85e-15 79.0 29CAW@1|root,2ZZ9C@2|Bacteria,1Q5FH@1224|Proteobacteria,42Q2S@68525|delta/epsilon subdivisions,2YP18@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_501702_1 187272.Mlg_0373 2.59e-62 203.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales 135613|Chromatiales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_501702_2 1499686.BN1079_01824 3.49e-72 221.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_991609_1 1121441.AUCX01000021_gene713 2.46e-48 176.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1QFX3@1224|Proteobacteria,42PIP@68525|delta/epsilon subdivisions,2WKWI@28221|Deltaproteobacteria,2MG9J@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Pyruvate phosphate dikinase, PEP pyruvate-binding - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_958076_1 553219.CAMSH0001_0976 2.42e-30 115.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,42M0Q@68525|delta/epsilon subdivisions,2YMXU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_958076_2 983328.AFGH01000035_gene1992 2.06e-68 220.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42M87@68525|delta/epsilon subdivisions,2YNA4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_41820_1 999541.bgla_1g29340 5.08e-09 53.9 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,1K8J9@119060|Burkholderiaceae 28216|Betaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_41820_2 1123487.KB892836_gene3119 4.95e-05 48.5 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,2KVRT@206389|Rhodocyclales 206389|Rhodocyclales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_76289_1 1390370.O203_05660 1.03e-41 161.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1YF2D@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M LppC putative lipoprotein lpoA GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07121 - - - - ko00000 - - - LppC k59_468332_1 96561.Dole_3030 1.02e-45 148.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria,2MKH5@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_566709_1 247490.KSU1_C1443 2.42e-21 97.1 COG1234@1|root,COG1234@2|Bacteria,2J27A@203682|Planctomycetes 203682|Planctomycetes S Beta-lactamase superfamily domain - - - - - - - - - - - - - k59_109155_1 469618.FVAG_01454 3.05e-91 284.0 COG0635@1|root,COG0635@2|Bacteria,3788G@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score 9.97 hemZ - - - - - - - - - - - Radical_SAM k59_109155_2 879212.DespoDRAFT_01023 5.89e-70 231.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MIF7@213118|Desulfobacterales 28221|Deltaproteobacteria U General secretion pathway protein F gspF - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_76295_1 926550.CLDAP_01010 4.37e-74 253.0 COG0784@1|root,COG2202@1|root,COG3290@1|root,COG3614@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3290@2|Bacteria,COG3614@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - - - - - - - - - - - CHASE,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_926454_1 1122212.AULO01000013_gene1986 2.71e-55 189.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1XHAE@135619|Oceanospirillales 135619|Oceanospirillales J beta-lactamase - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_892940_1 255470.cbdbA108 5.87e-85 277.0 COG0553@1|root,COG0553@2|Bacteria,2G6I4@200795|Chloroflexi,34DJG@301297|Dehalococcoidia 301297|Dehalococcoidia L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_303760_1 1121459.AQXE01000005_gene1556 2.83e-103 335.0 COG0574@1|root,COG3651@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3651@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42NYJ@68525|delta/epsilon subdivisions,2WKWS@28221|Deltaproteobacteria,2M9PD@213115|Desulfovibrionales 28221|Deltaproteobacteria GT Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_271036_1 338966.Ppro_2908 7.64e-28 118.0 COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria,43TMC@69541|Desulfuromonadales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_271036_2 96561.Dole_0566 6.71e-37 135.0 COG0004@1|root,COG0004@2|Bacteria,1R50W@1224|Proteobacteria,42PKR@68525|delta/epsilon subdivisions,2WM8P@28221|Deltaproteobacteria,2MII5@213118|Desulfobacterales 28221|Deltaproteobacteria P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_41835_1 555793.WSK_1933 2.03e-61 202.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,2K191@204457|Sphingomonadales 204457|Sphingomonadales S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_566714_1 1408473.JHXO01000011_gene3075 1.38e-55 179.0 COG0566@1|root,COG0566@2|Bacteria,4NFH3@976|Bacteroidetes,2FSSX@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA trmH - 2.1.1.34 ko:K00556 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_566714_2 1168034.FH5T_01190 2.39e-49 157.0 COG0776@1|root,COG0776@2|Bacteria,4NSK6@976|Bacteroidetes,2FTWW@200643|Bacteroidia 976|Bacteroidetes L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_338569_1 318167.Sfri_2291 1.54e-69 233.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2QAEU@267890|Shewanellaceae 1236|Gammaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_631987_1 749222.Nitsa_0481 4.6e-39 134.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,42QQM@68525|delta/epsilon subdivisions,2YNZA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT signal transduction sensor histidine kinase - - - - - - - - - - - - PAS,PAS_3 k59_631987_2 749222.Nitsa_0480 3.32e-20 82.4 2AK1D@1|root,31AQZ@2|Bacteria,1Q5ZH@1224|Proteobacteria,42V6N@68525|delta/epsilon subdivisions,2YQ6B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_207083_2 247490.KSU1_B0085 1.57e-08 64.7 COG5184@1|root,COG5184@2|Bacteria,2J3XT@203682|Planctomycetes 203682|Planctomycetes DZ Putative metal-binding motif - - - - - - - - - - - - Cu-binding_MopE k59_338577_1 709032.Sulku_2135 4.78e-94 288.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2YMID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_792928_2 395495.Lcho_0958 7.45e-05 46.2 COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,1KIWG@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Belongs to the ompA family ompA - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA k59_243855_2 1168034.FH5T_12540 1.64e-27 108.0 COG0564@1|root,COG0564@2|Bacteria,4NEV3@976|Bacteroidetes,2FMD1@200643|Bacteroidia 976|Bacteroidetes J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_796239_1 933262.AXAM01000062_gene948 8.88e-96 311.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MIEI@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_147309_1 59538.XP_005980035.1 1.07e-49 167.0 COG2518@1|root,KOG1661@2759|Eukaryota 2759|Eukaryota O protein-L-isoaspartate (D-aspartate) O-methyltransferase activity - GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT,Peptidase_M23 k59_472397_1 290512.Paes_0726 2.98e-11 64.7 COG1236@1|root,COG1236@2|Bacteria,1FER3@1090|Chlorobi 1090|Chlorobi J PFAM beta-lactamase domain protein - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_472397_2 1224746.B932_3009 6.04e-53 184.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria 28211|Alphaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC k59_604477_1 631362.Thi970DRAFT_00375 1.92e-87 269.0 COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,1WXWV@135613|Chromatiales 135613|Chromatiales E Catalyzes the sodium-dependent transport of glutamate - - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter k59_343586_1 1122613.ATUP01000001_gene874 7.84e-33 124.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,43XHW@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Belongs to the multicopper oxidase YfiH RL5 family yfiH - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_636933_1 348824.LPU83_1180 6.74e-62 201.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TS0W@28211|Alphaproteobacteria,4B708@82115|Rhizobiaceae 28211|Alphaproteobacteria S alcohol dehydrogenase adh - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_80505_2 1121015.N789_14460 9.86e-49 164.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1X4ZI@135614|Xanthomonadales 135614|Xanthomonadales U AAA domain - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_832402_1 1168289.AJKI01000007_gene157 2.96e-123 377.0 COG0542@1|root,COG0542@2|Bacteria,4NE1J@976|Bacteroidetes,2FNNW@200643|Bacteroidia,3XJJ6@558415|Marinilabiliaceae 976|Bacteroidetes O AAA ATPase domain clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_1028032_1 1095769.CAHF01000011_gene2162 2.5e-161 463.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,2W0HG@28216|Betaproteobacteria,4727U@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4478) - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_113490_2 349124.Hhal_0667 2.41e-33 124.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1WWI0@135613|Chromatiales 135613|Chromatiales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_796258_1 269799.Gmet_2794 2.74e-59 194.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria 28221|Deltaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_832403_1 1168034.FH5T_01760 4.98e-110 322.0 COG2877@1|root,COG2877@2|Bacteria,4NENN@976|Bacteroidetes,2FN47@200643|Bacteroidia 976|Bacteroidetes M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_963152_1 1458357.BG58_01510 5.34e-23 95.1 COG2353@1|root,COG2353@2|Bacteria,1RJFZ@1224|Proteobacteria,2WFN7@28216|Betaproteobacteria,1KFZJ@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_963152_2 399795.CtesDRAFT_PD2235 2.94e-32 121.0 COG2353@1|root,COG2353@2|Bacteria,1N3P9@1224|Proteobacteria,2VSMB@28216|Betaproteobacteria 28216|Betaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_472411_1 1042163.BRLA_c020390 1.54e-70 239.0 COG0454@1|root,COG3321@1|root,COG0456@2|Bacteria,COG3321@2|Bacteria 2|Bacteria Q synthase rhiF - - ko:K13611,ko:K13612,ko:K13614,ko:K15674,ko:K15679 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,Acetyltransf_1,Condensation,DinB_2,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_343613_1 1280946.HY29_04005 3.23e-37 147.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTUW@28211|Alphaproteobacteria,43WD3@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_439429_1 1537917.JU82_06215 5.89e-161 459.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2YMUA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_733295_1 572544.Ilyop_0622 7.73e-278 770.0 COG0504@1|root,COG0504@2|Bacteria,378S0@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_733295_2 1095747.HMPREF1049_1393 1.99e-46 158.0 COG0191@1|root,COG0191@2|Bacteria,378U7@32066|Fusobacteria 32066|Fusobacteria G Fructose-1,6-bisphosphate aldolase, class II fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_407273_1 1123393.KB891328_gene703 4.85e-145 416.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VIIQ@28216|Betaproteobacteria,1KSPD@119069|Hydrogenophilales 119069|Hydrogenophilales C Dehydrogenase E1 component - - - - - - - - - - - - E1_dh k59_275184_1 1441629.PCH70_17530 1.7e-34 130.0 COG1879@1|root,COG1879@2|Bacteria,1MWGU@1224|Proteobacteria,1RPE9@1236|Gammaproteobacteria,1Z4SN@136849|Pseudomonas syringae group 1236|Gammaproteobacteria G Periplasmic binding proteins and sugar binding domain of LacI family mglB GO:0005575,GO:0005623,GO:0006810,GO:0006935,GO:0008150,GO:0008643,GO:0008645,GO:0009605,GO:0015749,GO:0015757,GO:0015765,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:1901264,GO:1901656 - ko:K10439,ko:K10540,ko:K17205,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00214,M00591,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.15,3.A.1.2.19,3.A.1.2.3 - iPC815.YPO1507 Peripla_BP_4 k59_80546_1 1123073.KB899243_gene664 2.73e-67 218.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RRDQ@1236|Gammaproteobacteria,1X4AT@135614|Xanthomonadales 135614|Xanthomonadales V MatE - - - - - - - - - - - - MatE k59_113533_1 533247.CRD_00114 4.24e-42 150.0 COG0304@1|root,COG0304@2|Bacteria,1G1J5@1117|Cyanobacteria,1HM38@1161|Nostocales 1117|Cyanobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_113533_2 710111.FraQA3DRAFT_4656 9.77e-06 47.4 COG0236@1|root,COG0236@2|Bacteria,2INV8@201174|Actinobacteria 201174|Actinobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding k59_796289_1 1173024.KI912148_gene3523 3.44e-62 204.0 COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria 1117|Cyanobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - cobW k59_963181_1 1235793.C809_02544 2.89e-33 125.0 COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24MVR@186801|Clostridia,27M9K@186928|unclassified Lachnospiraceae 186801|Clostridia U Signal peptidase, peptidase S26 lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_670034_1 179408.Osc7112_4909 7.09e-24 105.0 COG0438@1|root,COG0463@1|root,COG1215@1|root,COG1216@1|root,COG5185@1|root,COG0438@2|Bacteria,COG0463@2|Bacteria,COG1215@2|Bacteria,COG1216@2|Bacteria,COG5185@2|Bacteria,1G3E3@1117|Cyanobacteria,1HH4F@1150|Oscillatoriales 1117|Cyanobacteria DM PFAM Glycosyl transferase family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_308704_1 1249627.D779_2705 1.29e-99 305.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales 135613|Chromatiales MU type I secretion outer membrane protein, TolC - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_374978_1 1235792.C808_05156 1.96e-06 46.6 COG1146@1|root,COG1146@2|Bacteria,1UE73@1239|Firmicutes,25J25@186801|Clostridia,27T4C@186928|unclassified Lachnospiraceae 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 k59_374978_2 1265505.ATUG01000001_gene4021 2.85e-45 155.0 COG0489@1|root,COG0489@2|Bacteria,1R6AC@1224|Proteobacteria,42NTJ@68525|delta/epsilon subdivisions,2WM95@28221|Deltaproteobacteria,2MJ5Z@213118|Desulfobacterales 28221|Deltaproteobacteria D protein tyrosine kinase activity - - - - - - - - - - - - - k59_636969_1 1121004.ATVC01000027_gene151 9.41e-68 224.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,2KQ92@206351|Neisseriales 206351|Neisseriales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_80554_1 1122134.KB893650_gene9 1.34e-58 200.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1XHEE@135619|Oceanospirillales 135619|Oceanospirillales P Chloride channel - - - - - - - - - - - - CBS,Voltage_CLC k59_897832_1 469616.FMAG_00263 1.16e-56 192.0 COG0438@1|root,COG0438@2|Bacteria,37A2I@32066|Fusobacteria 32066|Fusobacteria M Psort location Cytoplasmic, score - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_212289_1 4006.Lus10041041 2.79e-18 84.7 COG0087@1|root,COG0438@1|root,KOG0746@2759|Eukaryota,KOG0853@2759|Eukaryota,37R2V@33090|Viridiplantae,3G9PP@35493|Streptophyta,4JMY4@91835|fabids 35493|Streptophyta M Belongs to the glycosyltransferase 1 family - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008194,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0035251,GO:0044464,GO:0046524,GO:0046527,GO:0071944 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glycos_transf_1,S6PP,Sucrose_synth k59_243902_1 981085.XP_010098680.1 1.73e-47 156.0 COG0839@1|root,2QQHR@2759|Eukaryota,37N23@33090|Viridiplantae,3GCEY@35493|Streptophyta,4JS5P@91835|fabids 35493|Streptophyta C Belongs to the complex I subunit 6 family ndhG GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0044237 1.6.5.3 ko:K05578 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_q3 k59_243902_2 4113.PGSC0003DMT400029490 3.56e-56 176.0 KOG4669@1|root,KOG4669@2759|Eukaryota,37V63@33090|Viridiplantae,3GJK7@35493|Streptophyta,44TJB@71274|asterids 35493|Streptophyta C NADH-ubiquinone/plastoquinone oxidoreductase chain 4L ndhE GO:0003674,GO:0003824,GO:0003954,GO:0003959,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008137,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009987,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031976,GO:0031984,GO:0032991,GO:0034357,GO:0042180,GO:0042181,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0050136,GO:0051186,GO:0051188,GO:0055035,GO:0055114,GO:0071704,GO:0098796,GO:1901576,GO:1901661,GO:1901663,GO:1902494 1.6.5.3 ko:K05576 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_q2 k59_243902_3 3075.A0A023HHU3 5.03e-36 124.0 COG1145@1|root,2S26M@2759|Eukaryota,37VAY@33090|Viridiplantae,34IB8@3041|Chlorophyta 3041|Chlorophyta C essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA B D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin cytochrome c6- ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn psaC - - ko:K02691 ko00195,ko01100,map00195,map01100 M00163 - - ko00000,ko00001,ko00002,ko00194 - - - Fer4 k59_46198_1 765910.MARPU_08110 9.19e-39 140.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales 135613|Chromatiales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_733314_1 411901.BACCAC_03169 1.91e-35 130.0 28NZ3@1|root,2ZBW2@2|Bacteria,4NN5U@976|Bacteroidetes,2FKZ5@200643|Bacteroidia,4AP6X@815|Bacteroidaceae 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_507215_1 29760.VIT_08s0007g03280.t01 5.47e-67 215.0 COG0106@1|root,KOG3055@2759|Eukaryota,37JVT@33090|Viridiplantae,3GCV3@35493|Streptophyta 35493|Streptophyta E Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase - GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_701867_1 351348.Maqu_1434 4.17e-86 273.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,4659B@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941 Alpha-amylase,Alpha-amylase_C,CBM_48 k59_864591_1 243233.MCA1126 2.34e-88 271.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1XE9P@135618|Methylococcales 135618|Methylococcales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1028112_1 59538.XP_005979552.1 6.82e-32 127.0 COG0210@1|root,KOG0118@1|root,KOG0118@2759|Eukaryota,KOG2108@2759|Eukaryota,38I2J@33154|Opisthokonta 33154|Opisthokonta L ATP-dependent DNA helicase activity srs2 GO:0000018,GO:0000725,GO:0000726,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006282,GO:0006301,GO:0006302,GO:0006303,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008047,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009892,GO:0009893,GO:0009987,GO:0010569,GO:0010604,GO:0010605,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0022411,GO:0030234,GO:0031297,GO:0031323,GO:0031324,GO:0031325,GO:0032069,GO:0032070,GO:0032071,GO:0032075,GO:0032077,GO:0032079,GO:0032392,GO:0032508,GO:0032984,GO:0032986,GO:0033554,GO:0034641,GO:0034644,GO:0034645,GO:0042623,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0045738,GO:0045910,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051276,GO:0051336,GO:0051345,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070035,GO:0071103,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0098772,GO:0104004,GO:0140097,GO:1901360,GO:1901576,GO:2000042,GO:2000779,GO:2000780,GO:2001020,GO:2001021 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_996464_1 247490.KSU1_C1447 4.04e-58 204.0 COG0457@1|root,COG0457@2|Bacteria,2IXBT@203682|Planctomycetes 203682|Planctomycetes C deca-heme c-type cytochrome - - - - - - - - - - - - Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_2,TPR_8 k59_832479_1 1238184.CM001792_gene2726 2.81e-10 69.7 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,23JHA@182709|Oceanobacillus 91061|Bacilli O Subtilase family - - 3.4.21.66 ko:K08651 - - - - ko00000,ko01000,ko01002,ko03110 - - - PPC,Peptidase_S8 k59_407311_1 1517416.IDAT_10045 3.82e-90 283.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RXWZ@1236|Gammaproteobacteria,2QGUV@267893|Idiomarinaceae 1236|Gammaproteobacteria EU alpha/beta hydrolase fold - - - - - - - - - - - - Peptidase_S9 k59_931244_1 631362.Thi970DRAFT_01578 3.41e-39 147.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1WXTS@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3 k59_733323_1 1123401.JHYQ01000016_gene2966 2.84e-54 175.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,460RU@72273|Thiotrichales 72273|Thiotrichales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_733323_2 349521.HCH_04926 0.000514 41.6 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1XHAG@135619|Oceanospirillales 135619|Oceanospirillales K Transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_80594_1 90813.JQMT01000001_gene309 1.24e-49 170.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,461KC@72273|Thiotrichales 72273|Thiotrichales J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_1028130_1 247633.GP2143_15196 8.58e-74 235.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1J4SX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF k59_963203_2 1173021.ALWA01000007_gene3564 8.87e-23 102.0 COG1216@1|root,COG1216@2|Bacteria,1G2W7@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_571941_1 1049564.TevJSym_be00030 4.47e-85 261.0 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,1J5V7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Peptidase family U32 yhbV - - - - - - - - - - - Peptidase_U32 k59_275808_1 1415780.JPOG01000001_gene1823 6.92e-87 265.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1S4HN@1236|Gammaproteobacteria,1X9SZ@135614|Xanthomonadales 135614|Xanthomonadales EP Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_571948_1 326298.Suden_1812 8.69e-10 59.7 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2YMKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_180540_1 1114970.PSF113_5901 7.98e-75 240.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria,1YT9J@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_931800_1 990073.ATHU01000004_gene119 5.13e-39 139.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,42R50@68525|delta/epsilon subdivisions,2YNX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - - - - - - - - - - MoCF_biosynth k59_865331_1 1123326.JFBL01000017_gene2329 7.8e-56 190.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE k59_344211_1 323261.Noc_0363 1.57e-99 296.0 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind k59_10797_1 563040.Saut_1283 1.06e-72 221.0 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,42T86@68525|delta/epsilon subdivisions 1224|Proteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_1028628_1 339670.Bamb_2045 5.6e-10 65.1 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,1JZSU@119060|Burkholderiaceae 28216|Betaproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_605159_1 1168034.FH5T_05345 1.28e-133 403.0 COG0495@1|root,COG0495@2|Bacteria,4NE5K@976|Bacteroidetes,2FM7V@200643|Bacteroidia 976|Bacteroidetes J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,DUF559,tRNA-synt_1,tRNA-synt_1_2 k59_81182_1 1178482.BJB45_18675 2.51e-09 65.5 COG2304@1|root,COG4254@1|root,COG2304@2|Bacteria,COG4254@2|Bacteria,1QU09@1224|Proteobacteria,1T5WD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oxidoreductase activity - - - - - - - - - - - - - k59_114187_2 1237149.C900_01570 1.07e-55 194.0 COG0550@1|root,COG0550@2|Bacteria,4NF9S@976|Bacteroidetes,47K7C@768503|Cytophagia 976|Bacteroidetes L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt k59_473178_1 929558.SMGD1_1508 1.05e-115 342.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2YMCM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_309385_1 1123054.KB907716_gene147 1.75e-36 138.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,1WXVB@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 k59_114188_1 1123054.KB907703_gene1342 1.03e-11 66.2 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1WVVW@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_114188_2 292415.Tbd_2601 2.64e-05 50.8 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria 28216|Betaproteobacteria S permease - - - - - - - - - - - - AI-2E_transport k59_46840_1 1168034.FH5T_09890 9.36e-101 299.0 COG3016@1|root,COG3016@2|Bacteria,4NEQ4@976|Bacteroidetes,2FRHD@200643|Bacteroidia 976|Bacteroidetes S Haem-binding uptake, Tiki superfamily, ChaN - - - - - - - - - - - - Cofac_haem_bdg k59_605166_1 1123279.ATUS01000001_gene1020 6.58e-52 178.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1SZT5@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_275829_3 390874.Tpet_0688 6.7e-10 65.9 COG0770@1|root,COG0770@2|Bacteria,2GCZ1@200918|Thermotogae 200918|Thermotogae M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_833154_1 926556.Echvi_0881 1.28e-39 147.0 COG1652@1|root,COG4677@1|root,COG1652@2|Bacteria,COG4677@2|Bacteria,4P0WW@976|Bacteroidetes 976|Bacteroidetes G pectinesterase activity - - - - - - - - - - - - - k59_931819_2 314345.SPV1_12006 3.31e-14 70.9 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria 1224|Proteobacteria H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 ygdL GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0030955,GO:0031402,GO:0031420,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0061503,GO:0061504,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_571975_1 1168034.FH5T_07290 1.57e-33 126.0 COG1262@1|root,COG1262@2|Bacteria,4NGY2@976|Bacteroidetes,2FPTN@200643|Bacteroidia 976|Bacteroidetes M gliding motility-associated lipoprotein GldK gldK - - - - - - - - - - - FGE-sulfatase k59_571975_2 1168034.FH5T_07295 2.92e-42 146.0 COG0226@1|root,COG0226@2|Bacteria,4PKGM@976|Bacteroidetes,2G3GH@200643|Bacteroidia 976|Bacteroidetes P Type IX secretion system membrane protein PorP/SprF - - - - - - - - - - - - PorP_SprF k59_51079_2 387093.SUN_2326 1.31e-24 94.4 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2YPJZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_184804_1 572480.Arnit_1509 2.89e-47 182.0 COG2304@1|root,COG2911@1|root,COG2931@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,42TVF@68525|delta/epsilon subdivisions 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,VWA_2 k59_543969_1 1415780.JPOG01000001_gene1582 2.41e-19 87.8 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria,1X8GB@135614|Xanthomonadales 135614|Xanthomonadales NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_772097_1 1121874.KB892377_gene911 6.73e-25 99.4 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,3VQH6@526524|Erysipelotrichia 526524|Erysipelotrichia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_772097_2 469618.FVAG_01395 2.33e-37 129.0 COG0792@1|root,COG0792@2|Bacteria,37AGG@32066|Fusobacteria 32066|Fusobacteria L Uncharacterised protein family UPF0102 - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_772097_3 572544.Ilyop_1520 4.25e-36 122.0 COG3478@1|root,COG3478@2|Bacteria,37BA1@32066|Fusobacteria 32066|Fusobacteria S Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) - - - - - - - - - - - - zinc_ribbon_13 k59_772097_4 396588.Tgr7_0129 2.08e-06 55.1 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1WWVF@135613|Chromatiales 135613|Chromatiales S Competence protein - - - - - - - - - - - - Pribosyltran k59_118741_1 439235.Dalk_4966 5.88e-21 95.9 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MJ2D@213118|Desulfobacterales 28221|Deltaproteobacteria C FAD binding domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,Pyr_redox_2 k59_15287_1 1123253.AUBD01000004_gene1055 1.06e-42 144.0 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,1S98V@1236|Gammaproteobacteria,1X8P0@135614|Xanthomonadales 135614|Xanthomonadales P Rhodanese domain protein - - - - - - - - - - - - Rhodanese k59_801311_1 546271.Selsp_0630 8.78e-29 116.0 COG2826@1|root,COG2826@2|Bacteria,1TRSF@1239|Firmicutes,4H36B@909932|Negativicutes 909932|Negativicutes L Integrase core domain protein - - - - - - - - - - - - HTH_38,rve k59_444524_1 1123504.JQKD01000018_gene1979 2.45e-23 103.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,4AC5G@80864|Comamonadaceae 28216|Betaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_675207_1 1121924.ATWH01000006_gene1878 7.77e-08 53.9 COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4FKXU@85023|Microbacteriaceae 201174|Actinobacteria K regulation of nucleic acid-templated transcription yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_675207_2 1319815.HMPREF0202_02175 1.06e-18 87.0 COG1200@1|root,COG1200@2|Bacteria,378RT@32066|Fusobacteria 32066|Fusobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_184827_1 1168034.FH5T_21130 4.98e-66 212.0 COG1975@1|root,COG1975@2|Bacteria,4NG02@976|Bacteroidetes 976|Bacteroidetes O maturation factor XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_118751_1 485917.Phep_2074 4.27e-05 48.5 COG0782@1|root,COG0782@2|Bacteria,4NW1R@976|Bacteroidetes,1ITY1@117747|Sphingobacteriia 976|Bacteroidetes J transcription elongation factor GreA - - - ko:K06140 - - - - ko00000,ko03000 - - - GreA_GreB k59_152275_1 98439.AJLL01000097_gene2061 8.61e-83 261.0 COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria 1117|Cyanobacteria C NAD(P) transhydrogenase, alpha subunit pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_512173_1 1300345.LF41_2649 3.26e-18 89.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales 135614|Xanthomonadales T Adenylate cyclase - - - - - - - - - - - - - k59_184830_1 765913.ThidrDRAFT_1962 2.58e-106 342.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1141@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1141@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales 135613|Chromatiales C pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_380057_1 1049564.TevJSym_ca00050 3.53e-74 249.0 COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MMPL family VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_152277_1 1042375.AFPL01000040_gene2748 9.51e-16 71.6 COG3245@1|root,COG3245@2|Bacteria,1PEG2@1224|Proteobacteria,1SSHD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_152277_2 998088.B565_0140 5.93e-27 102.0 COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,1Y619@135624|Aeromonadales 135624|Aeromonadales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C k59_348633_1 1507.HMPREF0262_00710 2.25e-77 245.0 COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,36F3G@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase - - - ko:K07137 - - - - ko00000 - - - FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4 k59_119637_1 1408473.JHXO01000004_gene102 3.36e-85 273.0 COG1674@1|root,COG1674@2|Bacteria,4NE86@976|Bacteroidetes,2FMX0@200643|Bacteroidia 976|Bacteroidetes D FtsK SpoIIIE family protein ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_119637_2 1168034.FH5T_21305 4.31e-10 59.3 COG2834@1|root,COG2834@2|Bacteria,4NFGN@976|Bacteroidetes,2FQ63@200643|Bacteroidia 976|Bacteroidetes M outer membrane lipoprotein carrier protein LolA lolA - - ko:K03634 - - - - ko00000 - - - LolA,LolA_2 k59_1002339_1 948565.AFFP02000025_gene84 3.01e-14 72.8 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1Y7IZ@135625|Pasteurellales 135625|Pasteurellales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1002340_1 768671.ThimaDRAFT_3950 6.5e-70 214.0 COG3945@1|root,COG3945@2|Bacteria,1RBVC@1224|Proteobacteria,1S2ZK@1236|Gammaproteobacteria,1WY19@135613|Chromatiales 135613|Chromatiales S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_153158_1 1123065.ATWL01000006_gene2274 1.68e-58 200.0 COG1276@1|root,COG3336@1|root,COG1276@2|Bacteria,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria 201174|Actinobacteria P Cytochrome c oxidase - - - ko:K02351,ko:K07245 - - - - ko00000,ko02000 9.B.62.1 - - Caa3_CtaG,CopD k59_1033711_2 754477.Q7C_609 4.01e-40 142.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,460I1@72273|Thiotrichales 72273|Thiotrichales D Part of the ABC transporter FtsEX involved in cellular division - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_119646_1 880073.Calab_1030 8.17e-32 119.0 2E661@1|root,330UQ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_119646_2 1168034.FH5T_11750 3.1e-127 378.0 COG0173@1|root,COG0173@2|Bacteria,4NECY@976|Bacteroidetes,2FMCA@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_249824_1 387093.SUN_1431 4.51e-102 310.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2YN1U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_281039_1 1232683.ADIMK_3356 2.51e-55 192.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,4648F@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0339 Zn-dependent oligopeptidases prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_86533_1 1250232.JQNJ01000001_gene2918 1.69e-68 232.0 COG5511@1|root,COG5511@2|Bacteria 2|Bacteria F Phage portal protein, lambda family JD73_18735 - - - - - - - - - - - Phage_portal_2 k59_1002358_1 1168034.FH5T_06990 3.63e-104 312.0 COG1305@1|root,COG1305@2|Bacteria,4NEZ3@976|Bacteroidetes,2G2JQ@200643|Bacteroidia 976|Bacteroidetes E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core k59_707719_1 991905.SL003B_0176 1.57e-07 54.3 COG1595@1|root,COG1595@2|Bacteria,1RHRR@1224|Proteobacteria,2U9G0@28211|Alphaproteobacteria,4BQM8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_478365_1 96561.Dole_0762 1.77e-62 200.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MHP2@213118|Desulfobacterales 28221|Deltaproteobacteria Q Hypothetical methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - HTH_20,Methyltransf_31 k59_707722_1 290398.Csal_2112 6.45e-95 286.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1XIE0@135619|Oceanospirillales 135619|Oceanospirillales F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1033733_1 1198232.CYCME_0831 3.53e-69 218.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,460GB@72273|Thiotrichales 72273|Thiotrichales C PFAM Cytochrome C1 - - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_86543_1 983917.RGE_03800 6.09e-76 243.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VUHF@28216|Betaproteobacteria,1KPGU@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_513137_1 572547.Amico_1229 1.43e-49 161.0 COG1592@1|root,COG1592@2|Bacteria,3TAWZ@508458|Synergistetes 508458|Synergistetes C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_513137_2 1121904.ARBP01000001_gene5713 3.44e-39 137.0 2E1HF@1|root,32WVJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF3996 k59_281055_1 1537917.JU82_06190 4.77e-48 156.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2YMH3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E serine acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_314537_1 59374.Fisuc_0890 1.04e-35 129.0 COG1285@1|root,COG1285@2|Bacteria 2|Bacteria E pathogenesis - - - - - - - - - - - - DUF4956 k59_513138_1 446466.Cfla_1804 6.27e-46 156.0 COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4F183@85016|Cellulomonadaceae 201174|Actinobacteria O PFAM peptidyl-prolyl cis-trans isomerase cyclophilin type - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_185767_1 1168034.FH5T_00660 3.35e-89 281.0 COG3534@1|root,COG3534@2|Bacteria,4NGKW@976|Bacteroidetes,2FM0F@200643|Bacteroidia 976|Bacteroidetes G Carbohydrate binding domain - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C,CBM_4_9 k59_936971_1 1168034.FH5T_06980 2.23e-90 274.0 COG1408@1|root,COG1408@2|Bacteria,4NFCH@976|Bacteroidetes,2FQ9F@200643|Bacteroidia 976|Bacteroidetes S Ser Thr phosphatase family protein - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_445472_1 497964.CfE428DRAFT_2135 6.96e-31 114.0 COG0279@1|root,COG0279@2|Bacteria,46SXU@74201|Verrucomicrobia 74201|Verrucomicrobia G SIS domain gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_314544_1 861299.J421_4050 4.84e-28 117.0 COG5549@1|root,COG5549@2|Bacteria,1ZTC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Domain of unknown function (DUF5118) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 k59_513150_1 445973.CLOBAR_01284 2.66e-65 216.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,25QYT@186804|Peptostreptococcaceae 186801|Clostridia V transporter (ATP-binding protein) - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_577335_1 998088.B565_1873 5.74e-20 95.1 COG4928@1|root,COG4928@2|Bacteria,1MWRP@1224|Proteobacteria,1RZUM@1236|Gammaproteobacteria,1Y6CN@135624|Aeromonadales 135624|Aeromonadales S KAP family P-loop domain - - - - - - - - - - - - KAP_NTPase k59_86554_1 469604.HMPREF0946_01016 4.03e-06 50.8 COG0124@1|root,COG0124@2|Bacteria,378SC@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_86554_2 96561.Dole_1953 2.76e-36 141.0 COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2MI86@213118|Desulfobacterales 28221|Deltaproteobacteria L DEAD DEAH box helicase yprA - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C,RNase_H_2 k59_86554_3 760192.Halhy_2386 0.000222 41.6 COG0607@1|root,COG0607@2|Bacteria,4NVM6@976|Bacteroidetes,1IZ3G@117747|Sphingobacteriia 976|Bacteroidetes P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_610260_1 401053.AciPR4_2074 2.27e-32 128.0 COG1306@1|root,COG1306@2|Bacteria,3Y791@57723|Acidobacteria,2JKV4@204432|Acidobacteriia 204432|Acidobacteriia S Putative glycosyl hydrolase domain - - - - - - - - - - - - DUF4015 k59_969251_1 1165841.SULAR_01813 7.88e-55 179.0 COG0715@1|root,COG0715@2|Bacteria,1MVRA@1224|Proteobacteria,42M17@68525|delta/epsilon subdivisions 1224|Proteobacteria P NMT1/THI5 like thi - - ko:K15598 ko02010,map02010 M00442 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.3,3.A.1.17.6 - - NMT1 k59_969251_2 177437.HRM2_43010 3.2e-15 74.7 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2MIBF@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_739032_1 1449335.JQLG01000002_gene115 0.000935 47.8 COG5527@1|root,COG5527@2|Bacteria,1V8VU@1239|Firmicutes,4HWIQ@91061|Bacilli 91061|Bacilli L Initiator Replication protein - - - - - - - - - - - - Rep_3 k59_642862_1 387093.SUN_1947 5.61e-64 213.0 COG3307@1|root,COG3307@2|Bacteria,1N25I@1224|Proteobacteria,42RSJ@68525|delta/epsilon subdivisions,2YPDD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M PFAM O-Antigen - - - ko:K02847 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 - - Wzy_C k59_642862_2 1116472.MGMO_61c00380 5.96e-20 89.4 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1XDRH@135618|Methylococcales 135618|Methylococcales M TIGRFAM lipopolysaccharide heptosyltransferase I - - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_445483_1 1265313.HRUBRA_02633 3.31e-14 72.0 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1J6KT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - ko:K14055 - - - - ko00000 - - - Usp k59_249867_1 2903.EOD19812 1.6e-07 55.1 COG4581@1|root,KOG0947@2759|Eukaryota 2759|Eukaryota L nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay - GO:0000003,GO:0000373,GO:0000375,GO:0000377,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0006810,GO:0007275,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0008380,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009892,GO:0009987,GO:0010154,GO:0010467,GO:0010468,GO:0010494,GO:0010496,GO:0010497,GO:0010501,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016441,GO:0016458,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0022414,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032991,GO:0034641,GO:0035770,GO:0036464,GO:0040029,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048316,GO:0048519,GO:0048608,GO:0048731,GO:0048856,GO:0050789,GO:0051179,GO:0051234,GO:0060255,GO:0061458,GO:0065007,GO:0070013,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:1901360,GO:1901363,GO:1990904 - ko:K12599 ko03018,map03018 M00392 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,DSHCT,Helicase_C k59_870454_1 1168034.FH5T_04805 8.16e-102 312.0 COG2866@1|root,COG2866@2|Bacteria,4NF5T@976|Bacteroidetes 976|Bacteroidetes E Carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_610266_1 1168034.FH5T_04905 2.16e-84 258.0 COG5653@1|root,COG5653@2|Bacteria,4NQN5@976|Bacteroidetes,2FT4P@200643|Bacteroidia 976|Bacteroidetes M Protein involved in cellulose biosynthesis - - - - - - - - - - - - Acetyltransf_6 k59_802291_1 502025.Hoch_4109 1.31e-50 169.0 2DGG3@1|root,32U75@2|Bacteria,1RJCY@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_739039_1 1255043.TVNIR_3023 4.12e-63 202.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1WX89@135613|Chromatiales 135613|Chromatiales C PFAM cytochrome c oxidase, subunit III - - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_739039_2 1517416.IDAT_11915 9.48e-29 109.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,2QG0U@267893|Idiomarinaceae 1236|Gammaproteobacteria O Cytochrome c oxidase assembly protein CtaG/Cox11 ctaG - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_153211_1 95619.PM1_0229030 3.43e-69 229.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria 1236|Gammaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_707744_1 502025.Hoch_1020 7.07e-50 174.0 COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria,43BBP@68525|delta/epsilon subdivisions,2WRX0@28221|Deltaproteobacteria,2Z20S@29|Myxococcales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_153216_1 1408473.JHXO01000006_gene1015 1.63e-31 121.0 COG0696@1|root,COG0696@2|Bacteria,4NEQT@976|Bacteroidetes,2FMVJ@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_153216_2 1168034.FH5T_09400 3.97e-23 93.6 COG0727@1|root,COG0727@2|Bacteria,4NEPX@976|Bacteroidetes,2FNXY@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF3109 k59_544984_1 1168034.FH5T_05740 2.74e-107 338.0 COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,2FN0V@200643|Bacteroidia 976|Bacteroidetes G Glycoside hydrolase family 3 - - - - - - - - - - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C k59_577356_1 1476390.A0A060RFF1_9CAUD 6.39e-21 91.3 4QG8X@10239|Viruses,4QVDN@35237|dsDNA viruses no RNA stage,4QSBT@28883|Caudovirales,4QM55@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_188421_1 643562.Daes_2713 1.43e-98 298.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,42MNR@68525|delta/epsilon subdivisions,2WJ70@28221|Deltaproteobacteria,2M9YD@213115|Desulfovibrionales 28221|Deltaproteobacteria C Lysine 2,3-aminomutase YodO family protein kamA2 - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_188421_2 1121434.AULY01000007_gene1235 2.31e-12 66.6 COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,2M8FI@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_317147_1 1121405.dsmv_1777 4.06e-120 368.0 COG1743@1|root,COG1743@2|Bacteria,1P7I6@1224|Proteobacteria,42TQS@68525|delta/epsilon subdivisions,2WQIN@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA Methylase - - - - - - - - - - - - N6_N4_Mtase k59_89443_1 1123070.KB899254_gene1215 1.72e-07 54.7 COG1519@1|root,COG1519@2|Bacteria,46SK9@74201|Verrucomicrobia,2ITS4@203494|Verrucomicrobiae 203494|Verrucomicrobiae M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N k59_516044_1 339670.Bamb_4990 3.58e-20 85.9 2E66W@1|root,30WZZ@2|Bacteria,1PIS7@1224|Proteobacteria,2W7BH@28216|Betaproteobacteria,1KE9Q@119060|Burkholderiaceae 28216|Betaproteobacteria S RNP_Burkhold ribosomal natural product, two-chain TOMM family protein - - - - - - - - - - - - - k59_516044_2 342113.DM82_25 2.52e-21 87.4 2E66W@1|root,330VF@2|Bacteria,1N9N0@1224|Proteobacteria,2W1DI@28216|Betaproteobacteria,1KEGY@119060|Burkholderiaceae 28216|Betaproteobacteria S RNP_Burkhold ribosomal natural product, two-chain TOMM family protein - - - - - - - - - - - - - k59_841628_1 1121396.KB893112_gene2005 2.25e-49 166.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2WINX@28221|Deltaproteobacteria,2MI9X@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1037385_1 443143.GM18_3862 5.52e-08 51.2 COG1917@1|root,COG1917@2|Bacteria,1MZD8@1224|Proteobacteria,42W0P@68525|delta/epsilon subdivisions,2WRDR@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Cupin domain - - - - - - - - - - - - Cupin_2 k59_646475_1 1168034.FH5T_14055 1.13e-69 213.0 COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,2FT5G@200643|Bacteroidia 976|Bacteroidetes L Single-stranded DNA-binding protein ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_646475_2 1121097.JCM15093_1344 2.49e-40 146.0 COG1194@1|root,COG1194@2|Bacteria,4NDZY@976|Bacteroidetes,2FNMQ@200643|Bacteroidia,4AN85@815|Bacteroidaceae 976|Bacteroidetes L COG1194 A G-specific DNA glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_55349_1 396588.Tgr7_0696 1.33e-111 340.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales 135613|Chromatiales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_805717_1 768671.ThimaDRAFT_2417 1.06e-71 228.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RS8H@1236|Gammaproteobacteria,1WWVZ@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_156900_1 485915.Dret_0868 3.96e-57 199.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2M8MZ@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,PAS_4,PAS_9,Response_reg k59_189259_1 748247.AZKH_p0163 8.66e-68 225.0 COG1018@1|root,COG3894@1|root,COG1018@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2VZBE@28216|Betaproteobacteria 28216|Betaproteobacteria C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_516943_1 631362.Thi970DRAFT_02288 8.05e-87 271.0 COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria,1X0HX@135613|Chromatiales 135613|Chromatiales S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_940347_2 1392488.JHZY01000002_gene267 1.71e-26 112.0 COG1595@1|root,COG3533@1|root,COG4733@1|root,COG1595@2|Bacteria,COG3533@2|Bacteria,COG4733@2|Bacteria,4NHIK@976|Bacteroidetes,1I7M2@117743|Flavobacteriia 976|Bacteroidetes K Glycosyl hydrolase catalytic core - - - - - - - - - - - - CBM_4_9,Glyco_hydro_cc,Laminin_G_3 k59_805722_1 929558.SMGD1_1211 1.67e-73 227.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2YMEM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_253390_1 318167.Sfri_0356 4.1e-13 69.7 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,2QA2S@267890|Shewanellaceae 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_90338_1 1499967.BAYZ01000013_gene6453 2.48e-31 120.0 2CC7H@1|root,32RJ0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_156901_1 1288298.rosmuc_03687 1.57e-16 75.5 COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,2U9A2@28211|Alphaproteobacteria,46QRV@74030|Roseovarius 28211|Alphaproteobacteria S COG2166 SufE protein probably involved in Fe-S center assembly sufE - - ko:K02426 - - - - ko00000 - - - SufE k59_1005721_1 929558.SMGD1_2643 1.43e-238 678.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,42M43@68525|delta/epsilon subdivisions,2YM8G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the aconitase IPM isomerase family acnB GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0045333,GO:0046395,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:0097159,GO:1901363,GO:1901575 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_776451_1 1237149.C900_00249 8.55e-17 85.1 COG1629@1|root,COG1629@2|Bacteria,4NF88@976|Bacteroidetes,47JEF@768503|Cytophagia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 k59_352821_1 1298608.JCM18900_11619 0.000115 46.6 COG0328@1|root,COG0847@1|root,COG0328@2|Bacteria,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,3NKVD@468|Moraxellaceae 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids dnaQ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.1.26.4 ko:K02342,ko:K14159 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_H,RNase_T k59_352821_2 751994.AGIG01000027_gene1405 9.27e-49 168.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1J6D6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter nhaD - - - - - - - - - - - CitMHS k59_646492_1 494416.AYXN01000012_gene1224 1.8e-13 67.8 COG2227@1|root,COG2227@2|Bacteria,1QVH1@1224|Proteobacteria,1T2QF@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25 k59_646492_2 1038866.KB902824_gene1250 4.17e-29 111.0 2CM31@1|root,32SD0@2|Bacteria,1N2TZ@1224|Proteobacteria,2UH7X@28211|Alphaproteobacteria,3K1PA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_90342_2 1232410.KI421422_gene2086 2.45e-59 206.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TIGRFAM TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DctM k59_711289_1 452471.Aasi_0287 1.31e-29 120.0 COG0696@1|root,COG0696@2|Bacteria,4NEQT@976|Bacteroidetes,47K1F@768503|Cytophagia 976|Bacteroidetes G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_841648_1 387093.SUN_0471 7.3e-133 389.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2YN93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH anthranilate synthase component trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP1282 Anth_synt_I_N,Chorismate_bind k59_156915_1 387093.SUN_2456 9.45e-11 63.5 COG1574@1|root,COG1574@2|Bacteria,1R53N@1224|Proteobacteria,42R2P@68525|delta/epsilon subdivisions,2YRFE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_156915_2 565045.NOR51B_1649 6.08e-14 70.5 COG3316@1|root,COG3316@2|Bacteria,1MWZ2@1224|Proteobacteria,1RRC2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase and inactivated derivatives - - - ko:K07498 - - - - ko00000 - - - DDE_Tnp_IS240 k59_679642_1 1101191.KI912577_gene1306 5.12e-22 95.9 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,1JRAW@119045|Methylobacteriaceae 28211|Alphaproteobacteria C TIGRFAM cytochrome d ubiquinol oxidase, subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_317796_1 1177181.T9A_02952 3.59e-19 88.6 COG2114@1|root,COG5000@1|root,COG2114@2|Bacteria,COG5000@2|Bacteria,1MV1V@1224|Proteobacteria,1SZ0N@1236|Gammaproteobacteria,1XMTD@135619|Oceanospirillales 135619|Oceanospirillales T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_384601_1 387093.SUN_1107 4.36e-126 389.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2YMHU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_940375_1 269799.Gmet_1393 1.5e-89 279.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,43TCZ@69541|Desulfuromonadales 28221|Deltaproteobacteria NU General secretory system II, protein E domain protein pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding k59_1037451_2 572544.Ilyop_1506 1e-20 87.4 COG0571@1|root,COG0571@2|Bacteria,378UZ@32066|Fusobacteria 32066|Fusobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_55384_1 391615.ABSJ01000034_gene1097 2.89e-64 207.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1J4PY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - iYL1228.KPN_03597,ic_1306.c3945 polyprenyl_synt k59_874045_1 1120951.AUBG01000017_gene3331 5.61e-14 70.1 2CCSR@1|root,32RWC@2|Bacteria,4NUMI@976|Bacteroidetes,1I452@117743|Flavobacteriia 976|Bacteroidetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_874045_2 484770.UFO1_4078 7.78e-88 270.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,4H24Q@909932|Negativicutes 909932|Negativicutes G Transketolase, thiamine diphosphate binding domain protein - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_874045_3 6211.A0A068YD37 1.3e-20 94.0 COG0036@1|root,KOG3111@2759|Eukaryota,38G6J@33154|Opisthokonta,3BBFI@33208|Metazoa,3CTKR@33213|Bilateria 33208|Metazoa G Belongs to the ribulose-phosphate 3-epimerase family RPE GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0030246,GO:0034641,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0046983,GO:0048029,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_907176_1 768671.ThimaDRAFT_3894 1.75e-50 179.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales 135613|Chromatiales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_384619_1 637905.SVI_1901 3.77e-95 290.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria,2QCAD@267890|Shewanellaceae 1236|Gammaproteobacteria L Transposase DDE domain insG - - ko:K07495 - - - - ko00000 - - - DDE_Tnp_1,Nterm_IS4 k59_580750_1 187272.Mlg_1486 3.09e-50 160.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1WYW2@135613|Chromatiales 135613|Chromatiales C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4 k59_580750_2 216595.PFLU_5022 3.11e-51 169.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1YM65@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria F Nudix N-terminal - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_805748_1 713587.THITH_10330 2.56e-83 265.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales 135613|Chromatiales CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_805748_2 765914.ThisiDRAFT_1055 3.59e-35 122.0 COG0713@1|root,COG0713@2|Bacteria 2|Bacteria C ATP synthesis coupled electron transport - - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_805748_3 1379270.AUXF01000003_gene3531 3.53e-39 135.0 COG0839@1|root,COG0839@2|Bacteria,1ZUZB@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_548688_1 517417.Cpar_0501 1.29e-35 130.0 COG4420@1|root,COG4420@2|Bacteria,1FFB9@1090|Chlorobi 1090|Chlorobi S Protein of unknown function (DUF1003) - - - - - - - - - - - - DUF1003 k59_1037459_1 1168034.FH5T_03815 2.66e-93 297.0 COG0178@1|root,COG0178@2|Bacteria,4NFQU@976|Bacteroidetes,2FNMG@200643|Bacteroidia 976|Bacteroidetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_711316_1 1265313.HRUBRA_01475 6.02e-54 181.0 COG0746@1|root,COG0746@2|Bacteria,1QWF1@1224|Proteobacteria,1T603@1236|Gammaproteobacteria 1236|Gammaproteobacteria H MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_907178_1 1168034.FH5T_06685 8.1e-77 240.0 COG0322@1|root,COG0322@2|Bacteria,4NGEV@976|Bacteroidetes,2FNVF@200643|Bacteroidia 976|Bacteroidetes L COG NOG11654 non supervised orthologous group - - - - - - - - - - - - DUF4837 k59_907178_2 1203611.KB894549_gene2298 4.82e-09 53.1 COG1826@1|root,COG1826@2|Bacteria,4NUNH@976|Bacteroidetes 976|Bacteroidetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_156947_1 1286106.MPL1_06084 1.7e-27 108.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,45ZWD@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_156947_3 583345.Mmol_1667 1.07e-06 50.1 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,2KKRI@206350|Nitrosomonadales 206350|Nitrosomonadales G PFAM Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_156950_1 498211.CJA_0172 2.69e-54 188.0 COG5434@1|root,COG5434@2|Bacteria,1MXP8@1224|Proteobacteria,1RRJZ@1236|Gammaproteobacteria,1FFZ0@10|Cellvibrio 1236|Gammaproteobacteria G Glycosyl hydrolases family 28 - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_580764_1 1166018.FAES_4631 1.85e-22 103.0 COG1629@1|root,COG2373@1|root,COG1629@2|Bacteria,COG2373@2|Bacteria,4NG2S@976|Bacteroidetes,47K94@768503|Cytophagia 976|Bacteroidetes P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - A2M,A2M_N,A2M_comp,A2M_recep,Plug,Thiol-ester_cl k59_940392_1 1165841.SULAR_07325 4.22e-89 266.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2YMP8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP1386 Ribul_P_3_epim k59_284441_2 944546.ABED_0265 2.89e-79 262.0 COG1835@1|root,COG1835@2|Bacteria 2|Bacteria I transferase activity, transferring acyl groups other than amino-acyl groups ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - Acyl_transf_3,DUF4153 k59_742518_1 1049564.TevJSym_ag00990 1.82e-83 260.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1J4GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0569 K transport systems, NAD-binding component trkA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655 - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iE2348C_1286.E2348C_3552 TrkA_C,TrkA_N k59_516997_1 351348.Maqu_0017 4.47e-49 166.0 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,1T2MP@1236|Gammaproteobacteria,46D6V@72275|Alteromonadaceae 1236|Gammaproteobacteria V Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_123148_1 765912.Thimo_2429 3.08e-23 95.5 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales 135613|Chromatiales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_352862_1 756272.Plabr_3038 4.84e-66 218.0 COG0651@1|root,COG0651@2|Bacteria,2IXRM@203682|Planctomycetes 203682|Planctomycetes CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_907185_1 1165841.SULAR_05723 4.9e-52 171.0 COG0711@1|root,COG0711@2|Bacteria,1Q9TP@1224|Proteobacteria,42U87@68525|delta/epsilon subdivisions,2YPT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_156957_1 338963.Pcar_0519 1.3e-78 254.0 2E1TH@1|root,32X3B@2|Bacteria,1NKJB@1224|Proteobacteria 1224|Proteobacteria S Legionella pneumophila major outer membrane protein precursor - - - - - - - - - - - - Legionella_OMP k59_646541_1 608538.HTH_0602 6.66e-30 116.0 COG0436@1|root,COG0436@2|Bacteria,2G3UC@200783|Aquificae 200783|Aquificae E PFAM Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_352870_1 392499.Swit_3849 9.32e-27 112.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria,2K0E5@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase M48 - - - - - - - - - - - - Peptidase_M48,TPR_16 k59_907191_1 1537917.JU82_10650 7.29e-36 125.0 COG1331@1|root,COG1331@2|Bacteria,1QZMV@1224|Proteobacteria,43CKK@68525|delta/epsilon subdivisions,2YR0X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH,Thioredoxin_7 k59_189326_1 1232437.KL662061_gene4183 5.29e-35 125.0 COG0247@1|root,COG1149@1|root,COG0247@2|Bacteria,COG1149@2|Bacteria,1NTAE@1224|Proteobacteria,42YY3@68525|delta/epsilon subdivisions,2WUQ7@28221|Deltaproteobacteria,2MMW8@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_17 k59_189326_2 1121459.AQXE01000008_gene808 5.58e-16 73.6 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MBDN@213115|Desulfovibrionales 28221|Deltaproteobacteria C Cysteine-rich domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 k59_1037499_1 497321.C664_10148 6.3e-61 199.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2VIYE@28216|Betaproteobacteria,2KUH2@206389|Rhodocyclales 206389|Rhodocyclales L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_449279_1 324925.Ppha_0035 2.56e-18 85.1 COG1150@1|root,COG2181@1|root,COG1150@2|Bacteria,COG2181@2|Bacteria,1FEFH@1090|Chlorobi 1090|Chlorobi C 4Fe-4S dicluster domain - - - ko:K16887 - - - - ko00000 - - - Fer4_17 k59_776520_1 717774.Marme_1463 4.73e-36 138.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1XIQV@135619|Oceanospirillales 135619|Oceanospirillales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_776520_2 1131553.JIBI01000012_gene816 2.77e-85 262.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,371WY@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_742543_1 1168034.FH5T_07370 7.44e-31 113.0 COG0231@1|root,COG0231@2|Bacteria,4NDXA@976|Bacteroidetes,2FP84@200643|Bacteroidia 976|Bacteroidetes J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_485693_1 1165841.SULAR_07168 5.6e-36 132.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2YMB7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_977162_1 1165841.SULAR_00120 3.58e-123 383.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2YMA1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_553712_1 575594.ACOH01000010_gene1692 8.95e-08 52.8 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,3F4TZ@33958|Lactobacillaceae 91061|Bacilli L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_553712_2 933262.AXAM01000021_gene477 9.65e-37 125.0 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2WRI4@28221|Deltaproteobacteria,2MKRV@213118|Desulfobacterales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_454986_1 1123054.KB907725_gene3175 7.99e-08 53.5 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_454986_2 645991.Sgly_1723 6.5e-32 119.0 COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,24HE5@186801|Clostridia,261IS@186807|Peptococcaceae 186801|Clostridia H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_194051_1 2340.JV46_25740 3.8e-242 678.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1J4IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_3999 CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_194051_2 765912.Thimo_2775 2.72e-70 216.0 COG3154@1|root,COG3154@2|Bacteria,1RB7T@1224|Proteobacteria,1RMJD@1236|Gammaproteobacteria,1WY2A@135613|Chromatiales 135613|Chromatiales I Sterol-binding domain protein - - - - - - - - - - - - SCP2 k59_194051_3 95619.PM1_0218915 3.44e-62 199.0 COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,1S337@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity azoR GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006950,GO:0006979,GO:0008081,GO:0008150,GO:0008152,GO:0008770,GO:0009058,GO:0009108,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0016655,GO:0016661,GO:0016787,GO:0016788,GO:0032553,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046857,GO:0048037,GO:0050446,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363 - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 k59_194051_4 471854.Dfer_1016 6.02e-47 160.0 COG0800@1|root,COG0800@2|Bacteria,4NHVV@976|Bacteroidetes,47MP6@768503|Cytophagia 976|Bacteroidetes G KDPG and KHG aldolase - - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_194051_5 1049564.TevJSym_ab02070 2.75e-121 354.0 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,1S9D2@1236|Gammaproteobacteria,1J6WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_194051_6 357804.Ping_1553 1.35e-60 195.0 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria U UPF0056 membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_194051_7 1122134.KB893650_gene1298 7.28e-24 105.0 2FBD5@1|root,343IZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_194051_8 237368.SCABRO_02836 6.92e-66 206.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase paiA - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 k59_194051_9 879212.DespoDRAFT_03534 9.85e-94 279.0 COG0500@1|root,COG2226@2|Bacteria,1RFJD@1224|Proteobacteria,42S09@68525|delta/epsilon subdivisions,2WPB6@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_11,Nitro_FeMo-Co k59_194051_10 1249627.D779_2751 9.32e-63 196.0 COG3453@1|root,COG3453@2|Bacteria,1RHZ3@1224|Proteobacteria,1SH6N@1236|Gammaproteobacteria,1X1Z4@135613|Chromatiales 135613|Chromatiales S Putative phosphatase (DUF442) - - - - - - - - - - - - DUF442 k59_194051_11 1121035.AUCH01000007_gene436 4.02e-77 238.0 COG0664@1|root,COG0664@2|Bacteria,1RJU7@1224|Proteobacteria,2VZHQ@28216|Betaproteobacteria,2KYES@206389|Rhodocyclales 206389|Rhodocyclales K Cyclic nucleotide-monophosphate binding domain - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_194051_12 640081.Dsui_3351 1.08e-134 402.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VMKA@28216|Betaproteobacteria,2KW8I@206389|Rhodocyclales 206389|Rhodocyclales C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_194051_13 640081.Dsui_3350 1.61e-50 161.0 2ED9V@1|root,33769@2|Bacteria,1N87Z@1224|Proteobacteria,2W3PP@28216|Betaproteobacteria,2KZ35@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_194051_14 156889.Mmc1_2216 9.51e-58 185.0 COG1863@1|root,COG1863@2|Bacteria,1PDJ3@1224|Proteobacteria,2UDVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Na H antiporter mnhE - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_194051_15 640511.BC1002_6332 3.61e-17 76.3 COG2212@1|root,COG2212@2|Bacteria 2|Bacteria P antiporter activity mrpF - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k59_194051_16 156889.Mmc1_2214 5.58e-43 143.0 COG1320@1|root,COG1320@2|Bacteria,1N3BA@1224|Proteobacteria,2UDGG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Na+/H+ antiporter subunit - - - ko:K05571 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - PhaG_MnhG_YufB k59_194051_17 156889.Mmc1_2213 5.05e-23 91.3 COG1563@1|root,COG1563@2|Bacteria,1NI59@1224|Proteobacteria,2VG3W@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Domain of unknown function (DUF4040) - - - - - - - - - - - - DUF4040 k59_194051_18 870187.Thini_0561 9.1e-106 311.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Na H antiporter, MnhB - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_194051_19 870187.Thini_0562 7.42e-48 156.0 COG1006@1|root,COG1006@2|Bacteria,1QP28@1224|Proteobacteria,1SINF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P NADH-ubiquinone/plastoquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_194051_20 870187.Thini_0563 0.0 1440.0 COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,1T1AA@1236|Gammaproteobacteria 1236|Gammaproteobacteria CP Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_194051_21 870187.Thini_0564 1.38e-186 522.0 COG0650@1|root,COG0650@2|Bacteria,1QE37@1224|Proteobacteria,1RZJC@1236|Gammaproteobacteria 1236|Gammaproteobacteria C pfam nadh - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_420699_1 882.DVU_3064 6.57e-37 140.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,sCache_2 k59_521523_1 251229.Chro_2374 1.24e-27 114.0 COG1216@1|root,COG1216@2|Bacteria,1GQEZ@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_2,Glycos_transf_2 k59_553725_1 870187.Thini_0154 7.93e-73 234.0 COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,1S09M@1236|Gammaproteobacteria 1236|Gammaproteobacteria OQ Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_24416_1 75379.Tint_1590 2.07e-107 319.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2VJ31@28216|Betaproteobacteria,1KKBT@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_24416_2 1100721.ALKO01000033_gene191 2.94e-20 89.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,4ABKZ@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_194066_1 545693.BMQ_4890 2.77e-09 63.5 COG2267@1|root,COG2267@2|Bacteria,1W2QR@1239|Firmicutes,4I0G2@91061|Bacilli 91061|Bacilli I Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_226389_1 935837.JAEK01000043_gene3861 6.42e-176 508.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,4HA1G@91061|Bacilli,1ZASC@1386|Bacillus 91061|Bacilli G COG0366 Glycosidases yugT - 3.2.1.10,3.2.1.20 ko:K01182,ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R01718,R01791,R06087,R06088,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 - GH13,GH31 iSB619.SA_RS07580 Alpha-amylase,Malt_amylase_C k59_911564_1 1167006.UWK_01677 1.69e-43 155.0 COG0477@1|root,COG2814@2|Bacteria,1QWMM@1224|Proteobacteria,42PZZ@68525|delta/epsilon subdivisions,2WJ1J@28221|Deltaproteobacteria,2MIYY@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1 k59_1010063_1 1304878.AUGD01000001_gene195 8.94e-92 278.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3K066@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110 k59_1042480_1 177437.HRM2_39940 6.36e-95 281.0 COG2842@1|root,COG2842@2|Bacteria,1Q491@1224|Proteobacteria,42YN2@68525|delta/epsilon subdivisions,2WTMU@28221|Deltaproteobacteria,2MMGY@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposition protein - - - - - - - - - - - - - k59_257988_1 1168034.FH5T_08420 1.13e-243 681.0 COG0793@1|root,COG0793@2|Bacteria,4NEGV@976|Bacteroidetes,2FP0Y@200643|Bacteroidia 976|Bacteroidetes M Belongs to the peptidase S41A family ctp - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_945149_1 748280.NH8B_2004 4.39e-23 103.0 COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2VNR3@28216|Betaproteobacteria 28216|Betaproteobacteria K LuxR family transcriptional regulator - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_22,GerE k59_618681_1 387093.SUN_1457 2.89e-30 112.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2YQ5A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - - - - - - - - - - Macro k59_618681_2 387092.NIS_1756 1.19e-56 186.0 COG1028@1|root,COG1028@2|Bacteria,1RFQT@1224|Proteobacteria,43D9I@68525|delta/epsilon subdivisions,2YP3V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.320 ko:K16216 - - - - ko00000,ko01000 - - - adh_short k59_715695_1 1123035.ARLA01000027_gene450 3.02e-21 92.4 COG4623@1|root,COG4623@2|Bacteria,4NHFW@976|Bacteroidetes,1HZYC@117743|Flavobacteriia,4C3MP@83612|Psychroflexus 976|Bacteroidetes M Bacterial periplasmic substrate-binding proteins mltF - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_715695_2 1168034.FH5T_07455 6.14e-86 262.0 COG0191@1|root,COG0191@2|Bacteria,4NF5C@976|Bacteroidetes,2FNQM@200643|Bacteroidia 976|Bacteroidetes G Fructose-bisphosphate aldolase class-II fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_257990_1 243233.MCA0345 1.5e-104 312.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XE3A@135618|Methylococcales 135618|Methylococcales C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_321893_1 94624.Bpet0931 1.07e-79 248.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,3T2BU@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD - 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_194101_1 335543.Sfum_0712 5.13e-83 257.0 COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_485712_1 1168034.FH5T_05160 2.22e-101 321.0 COG0437@1|root,COG0437@2|Bacteria,4NE5M@976|Bacteroidetes 976|Bacteroidetes C Quinol cytochrome c oxidoreductase nrfC - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molydop_binding k59_911576_1 1266925.JHVX01000001_gene2483 2.78e-114 338.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales 28216|Betaproteobacteria O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_746826_1 519989.ECTPHS_06727 6.43e-101 308.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales 135613|Chromatiales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 k59_390266_1 32057.KB217478_gene5792 4.31e-58 198.0 COG3385@1|root,COG3385@2|Bacteria,1G2W3@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_585736_1 387093.SUN_2234 3.5e-19 86.7 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,43BP0@68525|delta/epsilon subdivisions,2YTEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LV TaqI-like C-terminal specificity domain - - - - - - - - - - - - N6_Mtase,TaqI_C k59_585736_2 683083.C414_000240011 5.91e-72 226.0 28I7P@1|root,2Z8AJ@2|Bacteria,1MY0A@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3800) rlfA - - - - - - - - - - - DUF3800 k59_585736_3 945550.VISI1226_20650 3.01e-42 146.0 2E0JQ@1|root,32W57@2|Bacteria,1N087@1224|Proteobacteria,1T13D@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_684148_1 269796.Rru_A0623 4.85e-32 121.0 COG2710@1|root,COG2710@2|Bacteria,1MVP0@1224|Proteobacteria,2TSK1@28211|Alphaproteobacteria,2JQH3@204441|Rhodospirillales 204441|Rhodospirillales C Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex bchN - 1.3.7.7 ko:K04038 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06282 RC01008 ko00000,ko00001,ko01000 - - - Oxidored_nitro k59_684148_2 1123072.AUDH01000025_gene378 2.11e-82 258.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,2TSTQ@28211|Alphaproteobacteria,2JQT8@204441|Rhodospirillales 204441|Rhodospirillales C Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex bchB - 1.3.7.7 ko:K04039 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06282 RC01008 ko00000,ko00001,ko01000 - - - Oxidored_nitro,PCP_red k59_945173_1 240016.ABIZ01000001_gene5341 3.9e-66 213.0 COG3287@1|root,COG3287@2|Bacteria 2|Bacteria M FIST C domain - - - - - - - - - - - - FIST,FIST_C,GGDEF k59_258017_1 387093.SUN_1357 2.17e-15 76.3 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,42RPB@68525|delta/epsilon subdivisions,2YP5G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q ABC-type transport system involved in resistance to organic solvents periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_258017_2 59196.RICGR_0579 2.82e-21 91.3 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RQVA@1236|Gammaproteobacteria,1JGH5@118969|Legionellales 118969|Legionellales P ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_781365_1 1168034.FH5T_16500 1.22e-118 340.0 COG1014@1|root,COG1014@2|Bacteria,4NGWJ@976|Bacteroidetes,2FNG6@200643|Bacteroidia 976|Bacteroidetes C 2-oxoacid ferredoxin flavodoxin oxidoreductase, gamma subunit porG - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_781365_2 1168034.FH5T_16495 2.1e-25 100.0 COG1013@1|root,COG1013@2|Bacteria,4NDWF@976|Bacteroidetes,2FP3C@200643|Bacteroidia 976|Bacteroidetes C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain vorA - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_60504_1 3847.GLYMA01G35681.1 1.77e-05 45.4 2CNIT@1|root,2QWJF@2759|Eukaryota,37RZQ@33090|Viridiplantae,3GF68@35493|Streptophyta,4JRTT@91835|fabids 35493|Streptophyta C Belongs to the reaction center PufL M PsbA D family psbD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0010287,GO:0016020,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 1.10.3.9 ko:K02706 ko00195,ko01100,map00195,map01100 M00161 - - ko00000,ko00001,ko00002,ko00194,ko01000 - - - Photo_RC k59_1042513_1 1049564.TevJSym_ak00590 1.02e-108 330.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1J5IS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_684162_1 1172190.M947_04105 1.97e-82 256.0 COG1672@1|root,COG1672@2|Bacteria,1PZGT@1224|Proteobacteria,42QN9@68525|delta/epsilon subdivisions,2YNKC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Archaea bacterial proteins of unknown function - - - ko:K06921 - - - - ko00000 - - - DUF234 k59_810302_1 1168034.FH5T_05010 2.06e-116 340.0 COG0809@1|root,COG0809@2|Bacteria,4NF2T@976|Bacteroidetes,2FMFT@200643|Bacteroidia 976|Bacteroidetes H Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_977240_1 1249480.B649_07980 6.16e-34 124.0 COG1226@1|root,COG1226@2|Bacteria,1R0RZ@1224|Proteobacteria,42UWU@68525|delta/epsilon subdivisions,2YQ24@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TrkA-N domain - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - TrkA_C,TrkA_N k59_977240_2 563040.Saut_1431 6.33e-16 78.2 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2YNJR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P potassium channel protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2,TrkA_C,TrkA_N k59_127612_1 1458357.BG58_12565 3.4e-31 132.0 COG0642@1|root,COG0745@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2WA95@28216|Betaproteobacteria,1K5PM@119060|Burkholderiaceae 28216|Betaproteobacteria T GAF domain - - - - - - - - - - - - GAF,HATPase_c,HisKA,Response_reg k59_321925_1 112098.XP_008619461.1 0.000996 43.5 KOG1539@1|root,KOG1539@2759|Eukaryota 2759|Eukaryota S rRNA processing WDR36 GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030684,GO:0030686,GO:0031974,GO:0031981,GO:0032040,GO:0032991,GO:0034388,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - ko:K14554,ko:K16353 ko03008,map03008 - - - ko00000,ko00001,ko03009,ko04516 - - - ANAPC4_WD40,Utp21,WD40 k59_321925_2 1123355.JHYO01000013_gene1072 6.47e-19 85.9 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,36X7C@31993|Methylocystaceae 28211|Alphaproteobacteria G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_194846_14 187272.Mlg_0030 1.16e-144 424.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1WWKR@135613|Chromatiales 135613|Chromatiales J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_194846_15 583345.Mmol_0497 1.75e-49 169.0 28JUM@1|root,2Z9JN@2|Bacteria,1NDV6@1224|Proteobacteria,2VJ3P@28216|Betaproteobacteria,2KMPZ@206350|Nitrosomonadales 206350|Nitrosomonadales - - - - - - - - - - - - - - - k59_194846_16 1049564.TevJSym_ab01320 1.79e-150 438.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_194846_17 1049564.TevJSym_ab01310 3.37e-110 324.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1J5TN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.100,1.5.1.33 ko:K00059,ko:K03793 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_194846_18 1537917.JU82_02020 3.31e-203 583.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,42MI1@68525|delta/epsilon subdivisions,2YMPQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Sulfatase eptA - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_194846_19 270374.MELB17_20431 2.11e-44 151.0 COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,46782@72275|Alteromonadaceae 1236|Gammaproteobacteria H COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase folK2 - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_194846_20 2340.JV46_28830 6.01e-56 176.0 COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1J6AD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB GO:0003674,GO:0003824,GO:0004150,GO:0005488,GO:0005515,GO:0016829,GO:0016830,GO:0016832,GO:0042802 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_2955,iECSE_1348.ECSE_3338,iPC815.YPO0648,iSBO_1134.SBO_2914,iSDY_1059.SDY_3241,iSFxv_1172.SFxv_3403,iUTI89_1310.UTI89_C3494,iYL1228.KPN_03462,ic_1306.c3808 FolB k59_194846_21 765912.Thimo_0558 1.6e-86 261.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1WWMS@135613|Chromatiales 135613|Chromatiales I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_194846_22 765911.Thivi_4080 1.12e-180 510.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1WWRX@135613|Chromatiales 135613|Chromatiales O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_194846_24 572477.Alvin_1841 5.9e-61 191.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1WYDV@135613|Chromatiales 135613|Chromatiales S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_194846_25 765912.Thimo_0553 3.72e-205 591.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales 135613|Chromatiales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_811227_1 1336233.JAEH01000005_gene1832 3.42e-08 60.5 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QD77@267890|Shewanellaceae 1236|Gammaproteobacteria T Histidine Phosphotransfer domain rcsC - 2.7.13.3 ko:K07677,ko:K07679,ko:K20974 ko02020,ko02025,ko02026,ko05133,map02020,map02025,map02026,map05133 M00474,M00477,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,HATPase_c,HisKA,Hpt,MASE1,PAS,PAS_3,PAS_4,PAS_9,RcsC,Response_reg,SBP_bac_3 k59_651444_1 572544.Ilyop_0309 2.89e-134 400.0 COG0370@1|root,COG0370@2|Bacteria,37888@32066|Fusobacteria 32066|Fusobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_194850_1 1123401.JHYQ01000006_gene134 1.09e-32 125.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,4600C@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_194850_2 545264.KB898751_gene2623 1.37e-93 280.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_685099_1 1121396.KB893101_gene488 2.11e-40 135.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,42W3M@68525|delta/epsilon subdivisions,2WP9C@28221|Deltaproteobacteria,2MK7D@213118|Desulfobacterales 28221|Deltaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_61256_1 639282.DEFDS_1394 3.12e-65 222.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GEXA@200930|Deferribacteres 200930|Deferribacteres C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8 k59_554609_1 306263.Cla_0685 7.68e-13 69.7 COG0477@1|root,COG2814@2|Bacteria,1QRUM@1224|Proteobacteria,42MFJ@68525|delta/epsilon subdivisions,2YMW9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_421346_1 1206733.BAGC01000054_gene2994 5.12e-25 110.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4FUGV@85025|Nocardiaceae 201174|Actinobacteria Q Peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_391011_1 1390370.O203_01575 5.43e-19 88.2 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1YFZU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S SURF1 family surf1 - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_162889_1 991905.SL003B_4216 1.8e-41 144.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,4BPVM@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_162889_2 929794.CALV01000021_gene846 1.63e-59 198.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,48TM4@772|Bartonellaceae 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_718454_1 861452.HMPREF9093_01419 3.79e-125 381.0 COG0220@1|root,COG1519@1|root,COG0220@2|Bacteria,COG1519@2|Bacteria,378F3@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527,ko:K03439 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03016 - GT30 - Glycos_transf_N,Methyltransf_4 k59_718454_2 572544.Ilyop_1376 2.89e-109 320.0 COG0220@1|root,COG0220@2|Bacteria,3786K@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_718454_3 572544.Ilyop_1375 6.37e-256 707.0 COG0104@1|root,COG0104@2|Bacteria,3793N@32066|Fusobacteria 32066|Fusobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_718454_4 572544.Ilyop_1374 2.73e-44 146.0 COG2739@1|root,COG2739@2|Bacteria,37AX7@32066|Fusobacteria 32066|Fusobacteria S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein - - - ko:K09787 - - - - ko00000 - - - UPF0122 k59_718454_5 572544.Ilyop_1373 6.97e-234 654.0 COG0541@1|root,COG0541@2|Bacteria,378I8@32066|Fusobacteria 32066|Fusobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_718454_6 1408439.JHXW01000005_gene1185 5.09e-41 136.0 COG0228@1|root,COG0228@2|Bacteria,37AM9@32066|Fusobacteria 32066|Fusobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_423360_1 1121405.dsmv_2721 2.53e-129 377.0 COG0067@1|root,COG0067@2|Bacteria,1MW6C@1224|Proteobacteria,42MTE@68525|delta/epsilon subdivisions,2WJ9E@28221|Deltaproteobacteria,2MI1S@213118|Desulfobacterales 28221|Deltaproteobacteria E glutamate synthase - - - - - - - - - - - - - k59_848466_1 616991.JPOO01000001_gene3463 1.4e-29 115.0 COG0415@1|root,COG0415@2|Bacteria,4NEDW@976|Bacteroidetes,1HXRR@117743|Flavobacteriia,23FXN@178469|Arenibacter 976|Bacteroidetes L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_848466_2 1341155.FSS13T_13020 1.98e-88 267.0 COG2227@1|root,COG2227@2|Bacteria,4NF6D@976|Bacteroidetes,1HXVW@117743|Flavobacteriia,2NTAA@237|Flavobacterium 976|Bacteroidetes H Methyltransferase type 12 - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_947734_1 1288494.EBAPG3_26360 1.82e-13 70.9 COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria,3722N@32003|Nitrosomonadales 28216|Betaproteobacteria M Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_947734_3 1352941.M877_00850 1.92e-12 67.8 COG0596@1|root,COG0596@2|Bacteria,2GMMB@201174|Actinobacteria 201174|Actinobacteria M Alpha beta hydrolase ephB GO:0003674,GO:0003824,GO:0004301,GO:0005488,GO:0005515,GO:0016787,GO:0016801,GO:0016803,GO:0018742,GO:0042802,GO:0042803,GO:0046983 - - - - - - - - - - Abhydrolase_1 k59_130393_1 879212.DespoDRAFT_03113 7.44e-125 358.0 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_947736_1 999549.KI421513_gene2099 8.94e-58 193.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,280EP@191028|Leisingera 28211|Alphaproteobacteria T Tetratricopeptide repeats - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_2,TPR_8 k59_97322_1 1187848.AJYQ01000076_gene1722 4.39e-19 89.4 COG1061@1|root,COG1112@1|root,COG1061@2|Bacteria,COG1112@2|Bacteria,1MWW9@1224|Proteobacteria,1TBUU@1236|Gammaproteobacteria,1XZ4H@135623|Vibrionales 135623|Vibrionales KL AAA domain - - - - - - - - - - - - AAA_11,AAA_12 k59_881064_1 765912.Thimo_0103 1.69e-122 374.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WVYX@135613|Chromatiales 135613|Chromatiales G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_979787_1 1168034.FH5T_16570 1.86e-95 306.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,4NF4F@976|Bacteroidetes,2FKZU@200643|Bacteroidia 976|Bacteroidetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1012544_1 762966.HMPREF9439_02561 2.93e-09 56.6 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2VUH0@28216|Betaproteobacteria,4PR5V@995019|Sutterellaceae 28216|Betaproteobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yqgF - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_1012544_2 768671.ThimaDRAFT_3038 1.36e-66 208.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales 135613|Chromatiales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_914178_2 1237149.C900_04087 2.71e-19 89.7 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes 976|Bacteroidetes V permease - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_653383_1 1388763.O165_027725 2.19e-67 214.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1YXCB@136845|Pseudomonas putida group 1236|Gammaproteobacteria J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006464,GO:0006479,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0016043,GO:0016740,GO:0016741,GO:0018364,GO:0019222,GO:0019538,GO:0022411,GO:0032259,GO:0032984,GO:0034641,GO:0034645,GO:0036009,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043414,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_260690_1 929558.SMGD1_0637 6.84e-25 97.1 COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,42V9C@68525|delta/epsilon subdivisions,2YQ7A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_260690_2 563040.Saut_0591 3.11e-113 337.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2YT0U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases tagE - - - - - - - - - - - Peptidase_M23 k59_260690_3 1537917.JU82_11870 1.01e-140 412.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2YMRG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H folylpolyglutamate synthase folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_653384_1 1384056.N787_05660 1.75e-26 105.0 COG0745@1|root,COG0745@2|Bacteria,1REEH@1224|Proteobacteria,1SZDK@1236|Gammaproteobacteria,1X6X6@135614|Xanthomonadales 135614|Xanthomonadales KT cheY-homologous receiver domain - - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_97338_2 768671.ThimaDRAFT_0733 2.72e-75 229.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WVXA@135613|Chromatiales 135613|Chromatiales K Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_749510_1 469610.HMPREF0189_00654 3.57e-25 105.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,1KK4Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria D Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_718511_1 929558.SMGD1_2653 6.57e-103 306.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2YMR0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_291980_1 1049564.TevJSym_au00170 5.83e-65 199.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,1J6AQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C ferredoxin, 2Fe-2S fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_291980_2 713586.KB900536_gene440 6.81e-11 57.4 COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Fe-S assembly protein IscX iscX GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - - - - - - - - - - Fe-S_assembly k59_813354_1 563040.Saut_1822 2.05e-40 146.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2YMP5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_813354_2 1249480.B649_01210 1.35e-106 322.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2YNBN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_718515_1 1499686.BN1079_03360 1.45e-14 81.6 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria 1236|Gammaproteobacteria L nucleotidyltransferase DNA polymerase involved in DNA repair imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_783813_1 99598.Cal7507_2520 7.49e-82 275.0 COG0496@1|root,COG3540@1|root,COG4222@1|root,COG4247@1|root,COG0496@2|Bacteria,COG3540@2|Bacteria,COG4222@2|Bacteria,COG4247@2|Bacteria,1G00S@1117|Cyanobacteria,1HIY4@1161|Nostocales 1117|Cyanobacteria I 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) - - 3.1.3.1,3.1.3.8,3.1.4.46 ko:K01083,ko:K01113,ko:K01126 ko00562,ko00564,ko00790,ko01100,ko02020,map00562,map00564,map00790,map01100,map02020 M00126 R01030,R01470,R03371,R04620 RC00017,RC00078,RC00425 ko00000,ko00001,ko00002,ko01000 - - - Calx-beta,DUF4114,Exo_endo_phos,GDPD,HemolysinCabind,PhoD,PhoD_N,Phytase,Phytase-like,SurE k59_62813_1 1255043.TVNIR_1954 7.94e-49 166.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_62813_2 713587.THITH_10375 2.74e-61 191.0 COG0852@1|root,COG0852@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3353 Complex1_30kDa k59_813370_1 572544.Ilyop_0911 1.75e-83 261.0 COG0312@1|root,COG0312@2|Bacteria,3795R@32066|Fusobacteria 32066|Fusobacteria S Putative modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_718531_1 765911.Thivi_4327 2.18e-116 345.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans - - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_653413_2 1244869.H261_05814 9.12e-06 47.4 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2U78S@28211|Alphaproteobacteria,2JS8G@204441|Rhodospirillales 204441|Rhodospirillales H Belongs to the MenA family. Type 1 subfamily menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_914222_1 981383.AEWH01000057_gene2409 8.38e-31 125.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes 1239|Firmicutes Q synthase - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_881104_1 1168034.FH5T_14070 2.43e-74 236.0 COG1530@1|root,COG1530@2|Bacteria,4NED1@976|Bacteroidetes,2FMXV@200643|Bacteroidia 976|Bacteroidetes J S1 RNA binding domain protein rng - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_947783_1 1121405.dsmv_2376 8.38e-216 623.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,Pyr_redox_2 k59_848516_1 330214.NIDE1438 3.01e-81 249.0 COG3000@1|root,COG3000@2|Bacteria 2|Bacteria I iron ion binding - - - - - - - - - - - - FA_hydroxylase k59_260745_1 1009370.ALO_04983 8.12e-14 75.5 COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,4H1US@909932|Negativicutes 909932|Negativicutes ET Belongs to the bacterial solute-binding protein 3 family glnH - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_260748_1 709032.Sulku_2151 2.11e-100 298.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2YMK7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_260748_2 929558.SMGD1_0838 1.08e-45 150.0 COG1544@1|root,COG1544@2|Bacteria,1QNAY@1224|Proteobacteria,430WG@68525|delta/epsilon subdivisions,2YS0N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Sigma 54 modulation protein / S30EA ribosomal protein - - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_293218_1 1173020.Cha6605_1310 7.35e-45 159.0 COG5659@1|root,COG5659@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - DDE_5 k59_489701_1 2340.JV46_24290 2.23e-47 161.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Hydrogenase formation hypA family hypD GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - ko:K04654 - - - - ko00000 - - - HypD k59_489701_3 318161.Sden_2581 1.16e-18 82.4 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,2QAM5@267890|Shewanellaceae 1236|Gammaproteobacteria P Plays a role in the regulation of phosphate uptake phoU GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_28236_1 886293.Sinac_2265 6.2e-22 99.0 COG2520@1|root,COG2520@2|Bacteria,2J555@203682|Planctomycetes 203682|Planctomycetes J TIGRFAM methyltransferase FkbM family - - - - - - - - - - - - Methyltransf_21 k59_64073_1 1380387.JADM01000001_gene222 8.74e-19 85.1 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1XJVK@135619|Oceanospirillales 135619|Oceanospirillales K Response regulator of the LytR AlgR family algR - - ko:K02477,ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_64073_2 207954.MED92_03762 1.72e-23 95.5 COG2143@1|root,COG2143@2|Bacteria,1NP6X@1224|Proteobacteria,1SBRN@1236|Gammaproteobacteria,1XKIM@135619|Oceanospirillales 135619|Oceanospirillales O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_882275_1 443143.GM18_2988 1.19e-185 533.0 COG0603@1|root,COG0603@2|Bacteria,1MXFU@1224|Proteobacteria,42T68@68525|delta/epsilon subdivisions,2WS4G@28221|Deltaproteobacteria 28221|Deltaproteobacteria F PP-loop superfamily ATPase - - - - - - - - - - - - QueC k59_64076_1 572477.Alvin_2880 6.72e-118 350.0 COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,1S0Z6@1236|Gammaproteobacteria,1WXDJ@135613|Chromatiales 135613|Chromatiales G Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_293247_1 1027273.GZ77_20855 9.35e-96 300.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1XHNC@135619|Oceanospirillales 135619|Oceanospirillales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_882284_1 1449050.JNLE01000003_gene2074 1.51e-18 90.1 COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae 186801|Clostridia Q Beta-ketoacyl synthase - - - ko:K13613 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_489744_1 1123376.AUIU01000011_gene1076 4.81e-75 238.0 COG0337@1|root,COG0337@2|Bacteria,3J0GA@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_489744_2 1408439.JHXW01000001_gene1844 1.47e-58 187.0 COG0703@1|root,COG0703@2|Bacteria,379GH@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_424733_1 929506.CbC4_0646 5.61e-78 247.0 COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,36FD4@31979|Clostridiaceae 186801|Clostridia G Belongs to the metallo-dependent hydrolases superfamily. NagA family nagA - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_28271_1 1168065.DOK_19160 9.56e-36 133.0 COG3547@1|root,COG3547@2|Bacteria,1RBIF@1224|Proteobacteria,1SDAR@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_849654_1 1396141.BATP01000014_gene2745 7.14e-79 250.0 COG0388@1|root,COG0388@2|Bacteria,46ZGG@74201|Verrucomicrobia,2IUQ5@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Carbon-nitrogen hydrolase - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_882301_1 765912.Thimo_2547 2.4e-55 182.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1WXND@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_814626_2 944546.ABED_1909 3.24e-75 233.0 COG1136@1|root,COG1136@2|Bacteria,1NVQS@1224|Proteobacteria,43AKA@68525|delta/epsilon subdivisions,2YM7X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_814626_3 749222.Nitsa_0517 3.94e-40 144.0 COG0577@1|root,COG0577@2|Bacteria,1P00G@1224|Proteobacteria,42P0D@68525|delta/epsilon subdivisions,2YMKU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter permease - - - - - - - - - - - - FtsX k59_489774_1 1168034.FH5T_00405 1.76e-132 387.0 COG0760@1|root,COG0760@2|Bacteria,4NEW0@976|Bacteroidetes,2FMDU@200643|Bacteroidia 976|Bacteroidetes M peptidylprolyl isomerase surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N_3 k59_326110_1 452471.Aasi_0895 0.000805 45.4 COG0790@1|root,COG0790@2|Bacteria,4NMCC@976|Bacteroidetes,47QS2@768503|Cytophagia 976|Bacteroidetes KLT Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Pkinase,Sel1,Tox-ODYAM1,U-box k59_326130_2 573569.F7308_0761 2.59e-26 117.0 COG1196@1|root,COG1196@2|Bacteria,1N82P@1224|Proteobacteria,1SEMH@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_489821_1 1485544.JQKP01000004_gene448 1.1e-29 124.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,44W7B@713636|Nitrosomonadales 28216|Betaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,NIT,PAS,PAS_4,PAS_9,Response_reg k59_849715_1 582515.KR51_00024560 3.56e-34 134.0 COG0606@1|root,COG0606@2|Bacteria,1G0K1@1117|Cyanobacteria 1117|Cyanobacteria O PFAM Magnesium chelatase, subunit ChlI comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_64158_1 1168034.FH5T_10415 1.57e-40 140.0 28MFD@1|root,2ZASV@2|Bacteria,4NH4N@976|Bacteroidetes,2FQXU@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_64158_2 1168034.FH5T_10435 4.39e-28 110.0 COG0826@1|root,COG0826@2|Bacteria,4NERN@976|Bacteroidetes,2FN1E@200643|Bacteroidia 976|Bacteroidetes O Peptidase, U32 family prtC - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_489842_1 1249627.D779_2413 5.22e-77 246.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales 135613|Chromatiales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_849727_1 1255043.TVNIR_0089 2.32e-97 301.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales 135613|Chromatiales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_814714_1 479434.Sthe_0290 1.17e-10 62.0 COG1028@1|root,COG1028@2|Bacteria,2G8II@200795|Chloroflexi,27XKN@189775|Thermomicrobia 189775|Thermomicrobia IQ Dehydrogenase reductase sdr - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_64187_1 765910.MARPU_07530 8.84e-66 224.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2RK@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - CHASE,HAMP,HATPase_c,HisKA,Hpt,MASE1,PAS_3,PAS_9,Response_reg k59_849751_1 641526.ADIWIN_4047 2.14e-35 142.0 COG5373@1|root,COG5373@2|Bacteria,4NGKV@976|Bacteroidetes,1HZB4@117743|Flavobacteriia 976|Bacteroidetes KT membrane - - - - - - - - - - - - DUF2339 k59_64195_1 861299.J421_6317 9.93e-39 152.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6317|- V efflux transmembrane transporter activity - - - - - - - - - - - - - k59_814728_1 1121004.ATVC01000041_gene959 1.29e-41 157.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,2KQ00@206351|Neisseriales 206351|Neisseriales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_882423_1 1231190.NA8A_09394 2.38e-06 50.1 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,2U7AP@28211|Alphaproteobacteria,43JVR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MA20_28295 - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_882423_2 754035.Mesau_04731 4.16e-21 95.1 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria,43J0E@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S AI-2E family transporter perM - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_489915_1 1165841.SULAR_03752 8.72e-113 341.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2YNMV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_293387_1 392499.Swit_1701 1.34e-32 128.0 COG0477@1|root,COG2814@2|Bacteria,1QZVG@1224|Proteobacteria,2TYEV@28211|Alphaproteobacteria,2KEM5@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_99019_2 1517681.HW45_00875 6.61e-38 143.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1XTH5@135623|Vibrionales 135623|Vibrionales D Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_458612_1 1249480.B649_11105 3.95e-32 120.0 2AI9D@1|root,318Q0@2|Bacteria,1Q0R3@1224|Proteobacteria,42SDN@68525|delta/epsilon subdivisions,2YP0E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_458612_2 1537917.JU82_02090 1.15e-51 169.0 COG5456@1|root,COG5456@2|Bacteria,1Q27X@1224|Proteobacteria,42V4G@68525|delta/epsilon subdivisions,2YQE8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P FixH - - - - - - - - - - - - FixH,YtkA k59_1014272_1 545243.BAEV01000028_gene671 2.58e-92 289.0 COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia,36UJ4@31979|Clostridiaceae 186801|Clostridia G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_66187_1 283942.IL0942 3.17e-08 55.5 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,2QFU5@267893|Idiomarinaceae 1236|Gammaproteobacteria T Phosphate starvation-inducible protein PhoH ybeZ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06217 - - - - ko00000 - - - PhoH k59_66187_2 631362.Thi970DRAFT_02251 7.22e-97 298.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_687438_1 246199.CUS_7037 8.19e-56 186.0 COG1175@1|root,COG1175@2|Bacteria,1TSMJ@1239|Firmicutes,24EBY@186801|Clostridia,3WRTB@541000|Ruminococcaceae 186801|Clostridia G ABC transporter, permease protein - - - - - - - - - - - - BPD_transp_1 k59_948902_1 469618.FVAG_01865 1.2e-07 58.5 COG2217@1|root,COG2217@2|Bacteria,378U0@32066|Fusobacteria 32066|Fusobacteria P Psort location CytoplasmicMembrane, score 10.00 cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase k59_654808_1 228410.NE1482 3.57e-126 368.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,371N5@32003|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_360612_2 331869.BAL199_00400 1.57e-36 134.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,4BT5R@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_29,rve,rve_3 k59_458618_1 709032.Sulku_0370 2.99e-80 253.0 COG1776@1|root,COG1776@2|Bacteria,1RICK@1224|Proteobacteria,42NMU@68525|delta/epsilon subdivisions,2YMV4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Chemotaxis phosphatase CheX - - - - - - - - - - - - CheX k59_916254_2 1454004.AW11_00250 4.74e-09 56.6 2EJDA@1|root,33D4B@2|Bacteria,1NJG2@1224|Proteobacteria,2VXQP@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_491206_1 1168034.FH5T_11860 2.52e-81 249.0 COG3176@1|root,COG3176@2|Bacteria,4PKEK@976|Bacteroidetes,2FKZ3@200643|Bacteroidia 976|Bacteroidetes S Hemolysin - - - - - - - - - - - - Acetyltransf_5 k59_425835_1 572480.Arnit_1510 5.67e-23 102.0 COG1538@1|root,COG1538@2|Bacteria,1N1Q8@1224|Proteobacteria,42Y0J@68525|delta/epsilon subdivisions 1224|Proteobacteria MU Outer membrane efflux protein - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP k59_33648_1 572544.Ilyop_1339 1.97e-94 292.0 COG1283@1|root,COG1283@2|Bacteria,378CQ@32066|Fusobacteria 32066|Fusobacteria P Na Pi-cotransporter II-like protein - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_33648_2 596323.HMPREF0554_1006 8.44e-93 275.0 COG0231@1|root,COG0231@2|Bacteria,378D7@32066|Fusobacteria 32066|Fusobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_622039_2 3880.AES88257 4.41e-51 162.0 COG0185@1|root,KOG0899@2759|Eukaryota,37W5Z@33090|Viridiplantae,3GKJU@35493|Streptophyta,4JVCU@91835|fabids 35493|Streptophyta J 30S ribosomal protein S19 rps19 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009507,GO:0009536,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_622039_3 57918.XP_004309313.1 4.13e-107 310.0 COG0090@1|root,KOG0438@2759|Eukaryota,37SZP@33090|Viridiplantae,3GDE2@35493|Streptophyta,4JTF7@91835|fabids 35493|Streptophyta J 50S ribosomal protein rpl2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - ko:K02886,ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C,Ribosomal_S19 k59_622039_4 4081.Solyc01g007630.2.1 2.52e-63 204.0 COG0090@1|root,KOG0438@2759|Eukaryota,37QJY@33090|Viridiplantae,3G9KA@35493|Streptophyta,44KYN@71274|asterids 35493|Streptophyta J Ribosomal Proteins L2, C-terminal domain rpl2 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0031967,GO:0031975,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L23,Ribosomal_L2_C k59_622039_5 29760.VIT_03s0038g02780.t01 1.77e-59 183.0 COG0089@1|root,2S1Z9@2759|Eukaryota,37VSJ@33090|Viridiplantae,3GJY5@35493|Streptophyta 35493|Streptophyta J ribosomal protein L23 rpl23 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_229832_2 1121342.AUCO01000008_gene105 1.29e-21 95.5 COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,24A5W@186801|Clostridia,36VIU@31979|Clostridiaceae 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC k59_164458_1 1408473.JHXO01000006_gene1385 9.41e-57 190.0 COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes,2FWBI@200643|Bacteroidia 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_589409_1 1528098.NOVO_04470 4.62e-31 120.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,47EUN@766|Rickettsiales 766|Rickettsiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_589409_2 666685.R2APBS1_2376 2.29e-30 112.0 COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,1SAC6@1236|Gammaproteobacteria,1X7KQ@135614|Xanthomonadales 135614|Xanthomonadales C succinate dehydrogenase sdhD - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_785426_2 246194.CHY_2518 1.5e-31 125.0 COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,249ZV@186801|Clostridia,42G1G@68295|Thermoanaerobacterales 186801|Clostridia L PFAM Integrase catalytic - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_66207_1 105559.Nwat_2261 2.44e-30 120.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_66207_2 1112209.AHVZ01000042_gene976 3.91e-16 76.3 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,3NJ52@468|Moraxellaceae 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_327951_1 1168034.FH5T_16685 1.3e-92 276.0 COG0705@1|root,COG0705@2|Bacteria,4NGT3@976|Bacteroidetes,2FMIT@200643|Bacteroidia 976|Bacteroidetes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Rhomboid k59_655438_1 1168034.FH5T_19480 1.08e-80 260.0 COG3137@1|root,COG3137@2|Bacteria,4NRXD@976|Bacteroidetes,2FNZ5@200643|Bacteroidia 976|Bacteroidetes M Protein of unknown function (DUF3078) - - - - - - - - - - - - DUF3078 k59_622600_1 1442598.JABW01000028_gene939 1.26e-90 281.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,42M6T@68525|delta/epsilon subdivisions,2YMJD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_622600_2 537971.HCCG_01521 1.17e-14 73.2 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QYV@68525|delta/epsilon subdivisions,2YNW5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Jag_N - - - ko:K06346 - - - - ko00000 - - - Jag_N k59_753279_1 406124.ACPC01000019_gene2819 1.91e-31 114.0 COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,4HJ3J@91061|Bacilli,1ZH3J@1386|Bacillus 91061|Bacilli S protein conserved in bacteria csoR_2 - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal k59_753279_3 485916.Dtox_2964 4.41e-06 48.5 COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,25AZU@186801|Clostridia,2673M@186807|Peptococcaceae 186801|Clostridia M pfam nlp p60 spr - - ko:K19224,ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - CBM50 - LysM,NLPC_P60,SH3_3 k59_197650_1 387093.SUN_0468 5.35e-111 323.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,42MG4@68525|delta/epsilon subdivisions,2YME4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K response regulator racR - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_589974_1 387093.SUN_0859 5.66e-42 148.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - ko:K12980 - - - - ko00000,ko01005 - - - OMP_b-brl k59_589974_2 387093.SUN_2371 3.43e-30 117.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2YMZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_361265_1 716544.wcw_1271 3.09e-73 238.0 COG1960@1|root,COG1960@2|Bacteria,2JFSS@204428|Chlamydiae 204428|Chlamydiae C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_785996_1 1168034.FH5T_13660 3.64e-112 340.0 COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,2FMK5@200643|Bacteroidia 976|Bacteroidetes T Tetratricopeptide repeat protein batD - - - - - - - - - - - BatD,TPR_2 k59_884068_1 999419.HMPREF1077_01471 2.43e-94 306.0 COG3250@1|root,COG3250@2|Bacteria,4NE7H@976|Bacteroidetes,2FNT8@200643|Bacteroidia,22WE2@171551|Porphyromonadaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_132297_1 765912.Thimo_1314 2.46e-53 169.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1WYVV@135613|Chromatiales 135613|Chromatiales J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_132297_2 2340.JV46_26330 7.37e-44 143.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,1J6MX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_165151_1 314278.NB231_04935 9.81e-26 107.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_165151_2 1403819.BATR01000062_gene1896 2.33e-26 103.0 2C85M@1|root,334CZ@2|Bacteria,46WIF@74201|Verrucomicrobia 74201|Verrucomicrobia S Stress responsive A/B Barrel Domain - - - - - - - - - - - - Dabb k59_426378_1 1144305.PMI02_01500 2.5e-05 52.4 COG0664@1|root,COG0664@2|Bacteria,1NTKW@1224|Proteobacteria,2VF3B@28211|Alphaproteobacteria,2K3N3@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix, cAMP Regulatory protein - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_622613_1 1206101.AZXC01000070_gene1892 2.3e-70 231.0 COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_785998_3 525318.HMPREF0497_2919 0.000169 43.1 COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,4HAMW@91061|Bacilli,3F4N6@33958|Lactobacillaceae 91061|Bacilli IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) kduD - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short,adh_short_C2 k59_851545_1 1077972.ARGLB_059_00060 0.000466 49.3 COG1262@1|root,COG2319@1|root,COG1262@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,1W9RX@1268|Micrococcaceae 201174|Actinobacteria S WD40 repeats - - - - - - - - - - - - AAA_16,PD40,TIR_2,WD40 k59_851545_2 929556.Solca_1423 1.53e-13 65.5 2BTNY@1|root,32NVY@2|Bacteria,4NV0G@976|Bacteroidetes,1IUM3@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF2905) - - - - - - - - - - - - DUF2905 k59_655458_1 96561.Dole_1062 3.79e-34 135.0 COG2114@1|root,COG2114@2|Bacteria,1NQPW@1224|Proteobacteria 1224|Proteobacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - - k59_589985_1 877415.JNJQ01000009_gene986 7.18e-68 218.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,3VNPX@526524|Erysipelotrichia 1239|Firmicutes P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_66765_1 29581.BW37_04138 1.33e-41 157.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,473CW@75682|Oxalobacteraceae 28216|Betaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_295711_2 709032.Sulku_1789 1.04e-52 170.0 COG2044@1|root,COG2044@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DrsE k59_295711_3 709032.Sulku_1790 4.49e-118 341.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,42U26@68525|delta/epsilon subdivisions,2YQ4F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K transcriptional regulator, Crp - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_688038_1 765913.ThidrDRAFT_2859 1.9e-47 174.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1WXN2@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) - - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_459296_1 1237149.C900_01709 5.63e-172 491.0 COG5433@1|root,COG5433@2|Bacteria,4NHJC@976|Bacteroidetes,47X71@768503|Cytophagia 976|Bacteroidetes L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_884075_1 1408303.JNJJ01000058_gene1262 2.08e-11 63.5 COG1898@1|root,COG1898@2|Bacteria,1TRVB@1239|Firmicutes,4HFQB@91061|Bacilli,1ZFCU@1386|Bacillus 91061|Bacilli M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_884075_2 1201293.AKXQ01000010_gene3248 6.52e-129 385.0 COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,1RPYU@1236|Gammaproteobacteria 1236|Gammaproteobacteria E homoserine dehydrogenase - - - - - - - - - - - - DapB_N,NAD_binding_3,SAF k59_884075_3 553177.CAPSP0001_0178 4.19e-48 159.0 COG1898@1|root,COG1898@2|Bacteria,4NNKW@976|Bacteroidetes,1I20V@117743|Flavobacteriia,1ER2T@1016|Capnocytophaga 976|Bacteroidetes G Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_720729_1 929558.SMGD1_1658 1.2e-123 361.0 COG3842@1|root,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,42MSG@68525|delta/epsilon subdivisions,2YMX7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E ATP-binding protein modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran k59_720729_2 572480.Arnit_0042 2.61e-118 343.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,42NZV@68525|delta/epsilon subdivisions,2YN88@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter permease modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_720729_3 1172190.M947_07610 1.07e-30 114.0 COG3585@1|root,COG3585@2|Bacteria,1N06J@1224|Proteobacteria,42U4N@68525|delta/epsilon subdivisions,2YQ5D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H TOBE domain - - - - - - - - - - - - TOBE k59_720729_4 1165841.SULAR_00665 2.37e-109 322.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42QWE@68525|delta/epsilon subdivisions,2YNG3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_720729_5 1172190.M947_02025 1.69e-119 366.0 COG4773@1|root,COG4773@2|Bacteria,1QZ1U@1224|Proteobacteria,42PHE@68525|delta/epsilon subdivisions,2YN5J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD k59_720729_6 709032.Sulku_1158 1.26e-82 256.0 COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,42RG9@68525|delta/epsilon subdivisions,2YMVF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Transcriptional regulator, ModE family modE - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1,TOBE k59_132319_1 941449.dsx2_1841 0.000275 49.7 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_393849_1 517418.Ctha_2072 2.32e-133 385.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 wbbL - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2 k59_393849_2 1537915.JU57_07985 4.39e-132 387.0 COG1835@1|root,COG1835@2|Bacteria,1R4WZ@1224|Proteobacteria 1224|Proteobacteria I Acyl-transferase - - - - - - - - - - - - Acyl_transf_3 k59_393849_3 1173029.JH980292_gene230 9.83e-22 100.0 COG1216@1|root,COG1216@2|Bacteria,1GQEZ@1117|Cyanobacteria,1HI6Y@1150|Oscillatoriales 1117|Cyanobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_tranf_2_2,Glycos_transf_2,Methyltransf_11,Methyltransf_23 k59_393849_4 1165841.SULAR_10499 6.68e-69 222.0 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2YNN5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Glycosyltransferase like family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_393849_5 1121923.GPUN_2861 5.72e-123 367.0 COG0438@1|root,COG0438@2|Bacteria,1PEGM@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase group 1 - - - - - - - - - - - - Glycos_transf_1 k59_393849_6 1537915.JU57_07955 2.38e-165 468.0 COG1087@1|root,COG1087@2|Bacteria,1QX2P@1224|Proteobacteria,42RZ1@68525|delta/epsilon subdivisions 1224|Proteobacteria M NAD-dependent epimerase dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_393849_7 1537915.JU57_07950 1.76e-114 331.0 COG0110@1|root,COG0110@2|Bacteria,1N6SQ@1224|Proteobacteria,42W16@68525|delta/epsilon subdivisions,2YTM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - Hexapep k59_197676_1 1168034.FH5T_16570 5.59e-215 627.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,4NF4F@976|Bacteroidetes,2FKZU@200643|Bacteroidia 976|Bacteroidetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_949564_1 857293.CAAU_0746 4.58e-35 124.0 COG2445@1|root,COG2445@2|Bacteria,1V6HC@1239|Firmicutes,24M25@186801|Clostridia,36J8T@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF86 - - - - - - - - - - - - DUF86 k59_361298_1 204773.HEAR2384 2.81e-19 85.5 COG1309@1|root,COG1309@2|Bacteria,1RARJ@1224|Proteobacteria,2VQUZ@28216|Betaproteobacteria,4782J@75682|Oxalobacteraceae 28216|Betaproteobacteria K BetI-type transcriptional repressor, C-terminal - - - - - - - - - - - - TetR_C_6,TetR_N k59_361298_2 406552.NJ7G_4276 3.93e-09 58.2 COG0667@1|root,arCOG01617@2157|Archaea,2XTHW@28890|Euryarchaeota,23SR4@183963|Halobacteria 183963|Halobacteria C oxidoreductases (related to aryl-alcohol dehydrogenases) - - - - - - - - - - - - Aldo_ket_red k59_361300_1 1165841.SULAR_05433 8.24e-73 225.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,42N66@68525|delta/epsilon subdivisions,2YMY7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_1014851_1 713586.KB900536_gene2639 3.04e-12 72.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_590009_1 631454.N177_3468 1.46e-77 234.0 28NR0@1|root,2ZBQD@2|Bacteria,1RA2I@1224|Proteobacteria,2U5BA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Nucleoside 2-deoxyribosyltransferase YtoQ ytoQ - - - - - - - - - - - Nuc_deoxyri_tr3 k59_99618_1 1168034.FH5T_01095 1.58e-82 260.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia 976|Bacteroidetes E Glutamate formimidoyltransferase ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N k59_524611_1 933262.AXAM01000014_gene226 5.62e-254 705.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2MJQY@213118|Desulfobacterales 28221|Deltaproteobacteria V PFAM N-6 DNA methylase hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_328579_1 1122179.KB890458_gene661 1.13e-32 117.0 COG0093@1|root,COG0093@2|Bacteria,4NNM6@976|Bacteroidetes,1ISEA@117747|Sphingobacteriia 976|Bacteroidetes J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_328579_2 1408415.JHXL01000010_gene965 9.6e-22 89.7 COG0198@1|root,COG0198@2|Bacteria,3WTRU@544448|Tenericutes 544448|Tenericutes J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_655490_1 96561.Dole_1552 2.33e-13 69.7 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJUN@28221|Deltaproteobacteria,2MIK6@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_491892_2 1095769.CAHF01000010_gene1133 1.44e-50 176.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4735B@75682|Oxalobacteraceae 28216|Betaproteobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_818743_2 572544.Ilyop_1285 0.0 1062.0 COG1185@1|root,COG1185@2|Bacteria,378Z4@32066|Fusobacteria 32066|Fusobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_818743_3 469617.FUAG_00541 2.42e-97 296.0 COG0621@1|root,COG0621@2|Bacteria,379IJ@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_720748_1 525898.Sdel_1232 2.69e-26 115.0 COG0666@1|root,COG5276@1|root,COG0666@2|Bacteria,COG5276@2|Bacteria,1R46A@1224|Proteobacteria 1224|Proteobacteria S LVIVD repeat - - - - - - - - - - - - Big_5,LVIVD k59_1014863_1 382464.ABSI01000012_gene2146 3.72e-41 154.0 COG1593@1|root,COG1593@2|Bacteria 2|Bacteria G mannitol 2-dehydrogenase activity - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM,DctQ k59_132346_1 709032.Sulku_0545 7.82e-133 381.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2YN3D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI GO:0003674,GO:0005488,GO:0005515,GO:0042802 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_132346_2 1537917.JU82_03315 8.93e-17 79.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2YMCI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_165196_1 1168034.FH5T_01600 0.0 950.0 COG1217@1|root,COG1217@2|Bacteria,4NDVM@976|Bacteroidetes,2FMNU@200643|Bacteroidia 976|Bacteroidetes T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_491898_2 709032.Sulku_0667 1.44e-82 261.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H ATP citrate synthase - - 2.3.3.8 ko:K15230 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,Ligase_CoA k59_295750_1 794903.OPIT5_21000 9.39e-55 181.0 COG0501@1|root,COG0501@2|Bacteria,46VES@74201|Verrucomicrobia,3K7XR@414999|Opitutae 414999|Opitutae O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_622648_2 523794.Lebu_0028 4.7e-206 587.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,3791J@32066|Fusobacteria 32066|Fusobacteria H Belongs to the precorrin methyltransferase family cobA - 2.1.1.107,4.2.1.75 ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,TP_methylase k59_622648_3 526218.Sterm_1024 1.61e-225 631.0 COG0001@1|root,COG0001@2|Bacteria,378IA@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_655504_1 1123368.AUIS01000019_gene1205 3.3e-33 125.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_492503_1 1042376.AFPK01000028_gene2019 2.02e-20 89.7 COG0366@1|root,COG0366@2|Bacteria,4NI8U@976|Bacteroidetes,1HYGV@117743|Flavobacteriia 976|Bacteroidetes G Alpha amylase, catalytic domain - - 2.4.1.4 ko:K05341 ko00500,map00500 - R01823 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_492503_2 572480.Arnit_0211 3.64e-71 226.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,42PX0@68525|delta/epsilon subdivisions 1224|Proteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis gpgS - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_329179_1 1121405.dsmv_2345 3.53e-91 285.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1R68U@1224|Proteobacteria,42M71@68525|delta/epsilon subdivisions,2WKG0@28221|Deltaproteobacteria,2MJ02@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,FlpD k59_623195_1 1336233.JAEH01000001_gene885 1.33e-42 160.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RYFT@1236|Gammaproteobacteria,2QACK@267890|Shewanellaceae 1236|Gammaproteobacteria EU PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 k59_950182_2 869213.JCM21142_73028 1.08e-108 328.0 COG3182@1|root,COG3182@2|Bacteria,4NHC5@976|Bacteroidetes 976|Bacteroidetes S PepSY domain protein - - - - - - - - - - - - PepSY_TM k59_753757_1 1357400.HMPREF2086_00872 1.78e-51 181.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2YMI1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Peptidase, M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_525218_1 385682.AFSL01000093_gene755 6.64e-62 208.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,2FNQB@200643|Bacteroidia,3XIMM@558415|Marinilabiliaceae 976|Bacteroidetes G pectate lyase K01728 - - - - - - - - - - - - - k59_917598_1 102107.XP_008224000.1 4.7e-240 715.0 28JZI@1|root,2QSDY@2759|Eukaryota,37J4T@33090|Viridiplantae,3GC2Z@35493|Streptophyta,4JREA@91835|fabids 35493|Streptophyta U Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope ycf1 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009507,GO:0009526,GO:0009528,GO:0009536,GO:0009706,GO:0009941,GO:0015031,GO:0015833,GO:0016020,GO:0019866,GO:0031090,GO:0031967,GO:0031969,GO:0031975,GO:0033036,GO:0042170,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - - - - - - - - - - Ycf1 k59_459939_1 519989.ECTPHS_02169 1.05e-81 253.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_34484_1 1408287.AXUR01000027_gene129 5.2e-17 85.9 COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,37909@32066|Fusobacteria 32066|Fusobacteria M Peptidase, M23 - - - - - - - - - - - - LysM,Peptidase_M23 k59_34484_2 572544.Ilyop_1453 6.03e-215 603.0 COG1158@1|root,COG1158@2|Bacteria,378DX@32066|Fusobacteria 32066|Fusobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_34484_3 572544.Ilyop_1454 1.36e-129 380.0 COG0530@1|root,COG0530@2|Bacteria 2|Bacteria P calcium, potassium:sodium antiporter activity yrbG - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_34484_4 1121935.AQXX01000139_gene3075 1.86e-21 96.3 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHS3@135619|Oceanospirillales 135619|Oceanospirillales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_9,Response_reg k59_34484_5 357804.Ping_1954 8.03e-190 541.0 COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB - - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - hDGE_amylase k59_34484_6 469618.FVAG_00157 1.05e-225 632.0 COG0621@1|root,COG0621@2|Bacteria,378TU@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_34484_7 572544.Ilyop_1457 1.99e-100 297.0 COG1059@1|root,COG1059@2|Bacteria,37905@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 8.96 ogg - 4.2.99.18 ko:K03653 - - - - ko00000,ko01000 - - - - k59_34484_8 994573.T472_0212710 1.46e-25 111.0 COG3768@1|root,COG3768@2|Bacteria,1V39W@1239|Firmicutes,24GI5@186801|Clostridia,36QFH@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF697) - - - - - - - - - - - - DUF697 k59_34484_10 1284352.AOIG01000015_gene4266 8.29e-47 155.0 COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,4HIJ3@91061|Bacilli,26XWC@186822|Paenibacillaceae 91061|Bacilli F Cytidine and deoxycytidylate deaminase zinc-binding region cdd - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 k59_34484_11 572544.Ilyop_1460 4.22e-135 386.0 COG0813@1|root,COG0813@2|Bacteria,3789D@32066|Fusobacteria 32066|Fusobacteria F purine-nucleoside phosphorylase deoD - 2.4.2.1 ko:K03784 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_34484_12 523794.Lebu_0728 4.35e-36 132.0 COG1015@1|root,COG1015@2|Bacteria,378FA@32066|Fusobacteria 32066|Fusobacteria G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme k59_67340_1 1249627.D779_3449 1.49e-65 219.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1WW6M@135613|Chromatiales 135613|Chromatiales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_296270_1 572480.Arnit_1643 1.91e-99 292.0 COG1247@1|root,COG1247@2|Bacteria,1R9WS@1224|Proteobacteria,42RZM@68525|delta/epsilon subdivisions,2YP9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_459947_1 864051.BurJ1DRAFT_1593 2.85e-09 63.2 COG0457@1|root,COG0457@2|Bacteria,1Q7UR@1224|Proteobacteria,2VKBS@28216|Betaproteobacteria,1KJ62@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_133002_1 335541.Swol_1688 1.46e-51 171.0 COG0500@1|root,COG2226@2|Bacteria,1V7SG@1239|Firmicutes,24AEB@186801|Clostridia 186801|Clostridia Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_133002_2 326298.Suden_1547 0.000613 42.0 COG1629@1|root,COG4771@2|Bacteria,1QZ2F@1224|Proteobacteria,42PWH@68525|delta/epsilon subdivisions,2YPE0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug k59_852242_1 485918.Cpin_4331 1.12e-12 68.6 COG2159@1|root,COG2159@2|Bacteria,4NPSE@976|Bacteroidetes,1ISGH@117747|Sphingobacteriia 976|Bacteroidetes S metal-dependent hydrolase of the TIM-barrel fold - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_492527_1 331678.Cphamn1_0514 1.18e-108 347.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - HemolysinCabind k59_198198_1 1408422.JHYF01000004_gene1569 8.59e-85 262.0 COG1082@1|root,COG1082@2|Bacteria,1U81K@1239|Firmicutes,2492P@186801|Clostridia,36EQ6@31979|Clostridiaceae 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_198198_2 572544.Ilyop_2925 6.42e-06 47.0 COG1028@1|root,COG1028@2|Bacteria,379JC@32066|Fusobacteria 32066|Fusobacteria IQ PFAM short-chain dehydrogenase reductase SDR - - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short,adh_short_C2 k59_34492_1 765911.Thivi_4145 6e-34 124.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,1WWFD@135613|Chromatiales 135613|Chromatiales K PFAM Cyclic nucleotide-binding - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_231060_1 1168034.FH5T_14100 6.44e-152 437.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase bamJ - - - - - - - - - - iSB619.SA_RS10050 Aminotran_1_2 k59_982675_1 1168034.FH5T_05025 3.56e-17 88.2 COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,2FM01@200643|Bacteroidia 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_753769_2 667014.Thein_0197 1.2e-44 150.0 COG1959@1|root,COG1959@2|Bacteria,2GGXM@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_525235_1 933262.AXAM01000084_gene1046 8.1e-101 305.0 COG0624@1|root,COG0624@2|Bacteria,1NYRF@1224|Proteobacteria,42SSP@68525|delta/epsilon subdivisions,2WP84@28221|Deltaproteobacteria,2MN7M@213118|Desulfobacterales 28221|Deltaproteobacteria E peptidase - - - - - - - - - - - - M20_dimer k59_296278_1 1168034.FH5T_21980 5.04e-127 381.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,2FN1K@200643|Bacteroidia 976|Bacteroidetes EU Peptidase, S9A B C family, catalytic domain protein pop GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - PD40,Peptidase_S9 k59_590559_1 1286171.EAL2_c14090 2.29e-08 53.9 COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,25UY6@186806|Eubacteriaceae 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_590559_2 1230342.CTM_21156 8.51e-88 266.0 COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,36FQ2@31979|Clostridiaceae 186801|Clostridia E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_590559_3 1174504.AJTN02000230_gene1226 1.79e-13 67.8 COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,4HFXQ@91061|Bacilli,1ZBC4@1386|Bacillus 91061|Bacilli E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_950217_1 1265502.KB905972_gene1345 3.01e-12 65.9 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2VJ01@28216|Betaproteobacteria,4A9PC@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase ahpF - - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_950217_2 640081.Dsui_2224 6.92e-41 140.0 COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,2VW5P@28216|Betaproteobacteria,2KXN3@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09790 - - - - ko00000 - - - DUF454 k59_525240_1 1168034.FH5T_17700 4.16e-93 287.0 COG0793@1|root,COG0793@2|Bacteria,4NEGV@976|Bacteroidetes,2FN98@200643|Bacteroidia 976|Bacteroidetes M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_1015374_1 1121939.L861_15905 2.37e-159 457.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,1RPST@1236|Gammaproteobacteria,1XM7H@135619|Oceanospirillales 135619|Oceanospirillales L Belongs to the 'phage' integrase family rci - - - - - - - - - - - Phage_integrase k59_1015374_2 1437448.AZRT01000057_gene509 2.37e-74 233.0 COG0084@1|root,COG0084@2|Bacteria,1R450@1224|Proteobacteria,2TUDR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L TatD-related deoxyribonuclease - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1015374_3 394221.Mmar10_2312 1.15e-96 304.0 COG0603@1|root,COG0603@2|Bacteria,1MXFU@1224|Proteobacteria,2U0CR@28211|Alphaproteobacteria,43ZUB@69657|Hyphomonadaceae 28211|Alphaproteobacteria F PP-loop superfamily ATPase - - - - - - - - - - - - QueC k59_1015374_4 406817.XNC1_p0120 3.73e-41 149.0 2DBMM@1|root,2Z9ZB@2|Bacteria,1Q9W2@1224|Proteobacteria,1RT7H@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1015374_5 1173020.Cha6605_6017 1.22e-164 489.0 COG4928@1|root,COG4928@2|Bacteria 2|Bacteria G KAP family P-loop domain - - - - - - - - - - - - KAP_NTPase k59_1015374_8 342113.DM82_1122 5.7e-25 108.0 COG3355@1|root,COG3355@2|Bacteria,1NAJT@1224|Proteobacteria,2W4NN@28216|Betaproteobacteria,1K6RU@119060|Burkholderiaceae 28216|Betaproteobacteria K ROK family - - - - - - - - - - - - HTH_36 k59_1015374_9 1219031.BBJR01000085_gene888 1.61e-93 281.0 COG5314@1|root,COG5314@2|Bacteria,1R6SS@1224|Proteobacteria,2VWXZ@28216|Betaproteobacteria,4AFD3@80864|Comamonadaceae 28216|Betaproteobacteria U Type IV secretion system proteins - - - ko:K03200 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T4SS k59_1015374_10 380358.XALC_2642 2.4e-44 149.0 2CG3T@1|root,2ZFS2@2|Bacteria,1PB4W@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_786603_1 457421.CBFG_00259 1.47e-26 108.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,26A5Y@186813|unclassified Clostridiales 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_133016_1 1168034.FH5T_07475 5.68e-93 286.0 COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes,2FMG2@200643|Bacteroidia 976|Bacteroidetes P Arylsulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_688660_1 1458357.BG58_12500 2.14e-56 182.0 COG1335@1|root,COG1335@2|Bacteria,1NZJ1@1224|Proteobacteria,2VKN5@28216|Betaproteobacteria,1K5W3@119060|Burkholderiaceae 1224|Proteobacteria Q Isochorismatase family - - 3.5.1.107 ko:K13995 ko00760,ko01120,map00760,map01120 M00622 R03540 RC00950 ko00000,ko00001,ko00002,ko01000 - - - Isochorismatase k59_852257_1 536232.CLM_1793 9.07e-34 124.0 COG1775@1|root,COG1775@2|Bacteria,1TSHM@1239|Firmicutes,249WE@186801|Clostridia,36EPN@31979|Clostridiaceae 186801|Clostridia E 2-hydroxyglutaryl-CoA dehydratase - - - - - - - - - - - - HGD-D k59_852257_2 526218.Sterm_4011 2.06e-48 168.0 COG1879@1|root,COG1879@2|Bacteria,3793S@32066|Fusobacteria 2|Bacteria G Periplasmic binding protein domain - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_459959_2 1122217.KB899575_gene1990 1.42e-67 219.0 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,4H48I@909932|Negativicutes 909932|Negativicutes K SMART Helix-turn-helix, AraC domain-containing protein - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC k59_361943_1 880072.Desac_2373 8.02e-78 238.0 COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,42UW2@68525|delta/epsilon subdivisions,2WQFD@28221|Deltaproteobacteria,2MS52@213462|Syntrophobacterales 28221|Deltaproteobacteria S ABC-type transport auxiliary lipoprotein component - - - ko:K09857 - - - - ko00000 - - - ABC_trans_aux k59_427488_1 1121405.dsmv_3570 3.63e-97 295.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1015997_1 1168034.FH5T_06470 6.82e-81 255.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,4NEBW@976|Bacteroidetes,2FMDF@200643|Bacteroidia 976|Bacteroidetes P TrkA C-terminal domain protein - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C k59_819939_1 765912.Thimo_2264 2.37e-74 242.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales 135613|Chromatiales F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_983216_1 1439940.BAY1663_03082 3.45e-102 310.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_558694_1 1283300.ATXB01000001_gene1158 4.66e-216 639.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales 135618|Methylococcales H Vitamin B12 dependent methionine synthase, activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_623819_1 572544.Ilyop_0543 8.72e-190 561.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,378RN@32066|Fusobacteria 32066|Fusobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_166440_1 1286106.MPL1_09410 1.33e-54 184.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,46007@72273|Thiotrichales 72273|Thiotrichales S DNA recombination protein RmuC - - - ko:K09760 - - - - ko00000 - - - RmuC k59_1016007_1 1168034.FH5T_19530 7.76e-70 239.0 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,2FNBJ@200643|Bacteroidia 976|Bacteroidetes S Psort location OuterMembrane, score 9.49 - - - - - - - - - - - - TamB k59_100887_2 497965.Cyan7822_5218 2.29e-21 95.1 COG1610@1|root,COG1610@2|Bacteria,1G607@1117|Cyanobacteria,3KI04@43988|Cyanothece 1117|Cyanobacteria D Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_918366_1 1123234.AUKI01000017_gene2691 7.47e-08 56.2 COG0702@1|root,COG0702@2|Bacteria,4PKHQ@976|Bacteroidetes,1IJ9C@117743|Flavobacteriia 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_35081_1 997346.HMPREF9374_3510 8.98e-39 140.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,27AZ9@186824|Thermoactinomycetaceae 91061|Bacilli I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_950891_1 1353531.AZNX01000037_gene3804 1.98e-52 181.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_591125_1 1129374.AJE_17610 2.93e-18 84.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,464U6@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG2133 Glucose sorbosone dehydrogenases yliI GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363 - ko:K21430 - - - - ko00000,ko01000 - - iSbBS512_1146.SbBS512_E2507 GSDH k59_591125_2 522306.CAP2UW1_2571 2.84e-28 117.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2VJ4Z@28216|Betaproteobacteria 28216|Betaproteobacteria P TrkA-N domain protein - - - - - - - - - - - - Ion_trans_2,TrkA_N k59_754371_1 1380600.AUYN01000009_gene1077 7.33e-17 84.3 COG2133@1|root,COG2133@2|Bacteria,4NF61@976|Bacteroidetes 976|Bacteroidetes G Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - - - - - - - - - - VCBS k59_68267_2 598659.NAMH_0543 4.03e-80 243.0 COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2YM8K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate ribA - 3.5.4.25 ko:K01497 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125 R00425 RC00293,RC02504 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydro2 k59_951204_1 1172190.M947_02635 8.03e-39 137.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,43B0D@68525|delta/epsilon subdivisions,2YT4V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RluA family - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_951204_2 326298.Suden_2095 6.18e-62 202.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2YMZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_362563_1 1232437.KL662011_gene1477 4.14e-116 347.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria,2MHXY@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_8 k59_559054_1 1049564.TevJSym_an00030 4.92e-40 146.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7AF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F 5'-nucleotidase, C-terminal domain soxB - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_657256_1 1304284.L21TH_2713 1.42e-23 99.0 COG0044@1|root,COG0044@2|Bacteria,1TPI6@1239|Firmicutes,2495I@186801|Clostridia,36UWD@31979|Clostridiaceae 186801|Clostridia F Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation iadA - - ko:K01305 - - - - ko00000,ko01000,ko01002 - - - Amidohydro_1,Amidohydro_3 k59_657256_3 101028.EKJ77860 2.69e-13 74.3 COG1564@1|root,KOG3153@2759|Eukaryota,391MK@33154|Opisthokonta,3P2EK@4751|Fungi,3QP67@4890|Ascomycota,213CJ@147550|Sordariomycetes,3TFDE@5125|Hypocreales,1FRSY@110618|Nectriaceae 4751|Fungi H Belongs to the thiamine pyrophosphokinase family THI80 GO:0003674,GO:0003824,GO:0004788,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006732,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009229,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042357,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 - R00619 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TPK_B1_binding,TPK_catalytic k59_657256_4 1123009.AUID01000025_gene90 2.89e-18 85.5 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,2686Y@186813|unclassified Clostridiales 186801|Clostridia V MatE - - - - - - - - - - - - MatE k59_754615_2 1144319.PMI16_01958 5.36e-20 84.7 COG3628@1|root,COG3628@2|Bacteria,1N23A@1224|Proteobacteria,2WCPT@28216|Betaproteobacteria,47810@75682|Oxalobacteraceae 28216|Betaproteobacteria S Gene 25-like lysozyme - - - ko:K06903 - - - - ko00000 - - - GPW_gp25 k59_493491_1 1232437.KL661978_gene3837 1.2e-49 170.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42M3I@68525|delta/epsilon subdivisions,2WIXZ@28221|Deltaproteobacteria,2MI4J@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - - - - - - - - - - Dus k59_35368_1 1408422.JHYF01000004_gene1503 9.88e-127 377.0 COG1906@1|root,COG1906@2|Bacteria,1V5AX@1239|Firmicutes,24JFK@186801|Clostridia,36PN0@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF401) - - - ko:K09133 - - - - ko00000 - - - DUF401 k59_820254_1 314230.DSM3645_20627 2.59e-32 128.0 COG1520@1|root,COG1520@2|Bacteria,2IWR8@203682|Planctomycetes 203682|Planctomycetes S beta-propeller repeat - - - - - - - - - - - - PQQ_2 k59_231969_1 1449050.JNLE01000003_gene3691 1.05e-17 80.5 COG3711@1|root,COG3711@2|Bacteria,1TT5A@1239|Firmicutes,24931@186801|Clostridia,36H6I@31979|Clostridiaceae 186801|Clostridia K CAT RNA binding domain - - - ko:K03488 - - - - ko00000,ko03000 - - - CAT_RBD,PRD k59_231969_2 1449050.JNLE01000003_gene3692 1.34e-60 199.0 COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia,36DZU@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 1 family bglC - 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT1 - Glyco_hydro_1 k59_526278_2 635013.TherJR_2684 1.12e-54 181.0 COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia,260R3@186807|Peptococcaceae 186801|Clostridia K PFAM response regulator receiver arlR - - - - - - - - - - - Response_reg,Trans_reg_C k59_526278_3 1122917.KB899659_gene5053 2.87e-28 124.0 COG5002@1|root,COG5002@2|Bacteria,1TPSK@1239|Firmicutes,4HAH5@91061|Bacilli,26R1A@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase - - 2.7.13.3 ko:K18940 ko02020,map02020 M00716,M00717 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_657267_1 396588.Tgr7_1275 2.38e-116 343.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1WWD8@135613|Chromatiales 135613|Chromatiales O Belongs to the HypD family - - - ko:K04654 - - - - ko00000 - - - HypD k59_101265_1 1125863.JAFN01000001_gene1979 1.32e-76 235.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM ABC transporter related - - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_591395_1 1266909.AUAG01000028_gene1645 2.75e-106 339.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_101268_1 1410634.JHVD01000019_gene1359 1.91e-16 84.3 COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4DPRS@85009|Propionibacteriales 201174|Actinobacteria CP Domain related to MnhB subunit of Na+/H+ antiporter mrpA/mrpB - - ko:K05565,ko:K14086 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N k59_362582_1 373903.Hore_10060 4.65e-90 268.0 COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,3WAMD@53433|Halanaerobiales 186801|Clostridia C TIGRFAM hydro-lyases, Fe-S type, tartrate fumarate subfamily, beta region fumB - 4.2.1.2 ko:K01678 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase_C k59_362582_2 293826.Amet_2965 4.18e-196 554.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae 186801|Clostridia C malic enzyme - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_134126_1 879212.DespoDRAFT_00763 2.51e-101 320.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_427750_1 159087.Daro_1317 1.09e-90 275.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,2KUKA@206389|Rhodocyclales 206389|Rhodocyclales P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components oppB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_231982_1 1172190.M947_06560 3.16e-77 261.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2YMJS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,NIT,Response_reg k59_461032_1 96561.Dole_3232 3.11e-49 169.0 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,42P1A@68525|delta/epsilon subdivisions,2WM73@28221|Deltaproteobacteria,2MIVM@213118|Desulfobacterales 28221|Deltaproteobacteria I enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_134131_1 1205680.CAKO01000024_gene4509 5.34e-27 115.0 2F26G@1|root,33V4S@2|Bacteria,1NUS1@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_264302_1 1168034.FH5T_01640 1.03e-75 238.0 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - - - - - - - - - - PQQ_2 k59_330216_1 864073.HFRIS_001859 2.65e-98 296.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,4728E@75682|Oxalobacteraceae 28216|Betaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3,OmpA k59_199127_1 768671.ThimaDRAFT_0038 4.37e-66 214.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,1RZVF@1236|Gammaproteobacteria,1WXBS@135613|Chromatiales 135613|Chromatiales M NlpB/DapX lipoprotein - - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_297166_1 1430440.MGMSRv2_1559 2.36e-32 131.0 COG0784@1|root,COG4564@1|root,COG5000@1|root,COG0784@2|Bacteria,COG4564@2|Bacteria,COG5000@2|Bacteria,1NC9X@1224|Proteobacteria,2TXEG@28211|Alphaproteobacteria,2JW4T@204441|Rhodospirillales 204441|Rhodospirillales T Cache 3/Cache 2 fusion domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,Response_reg,dCache_2 k59_101285_2 1499685.CCFJ01000056_gene309 8.8e-27 110.0 COG1752@1|root,COG1752@2|Bacteria,1UUVB@1239|Firmicutes,4HDFQ@91061|Bacilli,1ZBCG@1386|Bacillus 91061|Bacilli S esterase of the alpha-beta hydrolase superfamily ylbK GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_68308_2 1168034.FH5T_11090 1.44e-66 209.0 29X7V@1|root,30IX4@2|Bacteria,4PMJ5@976|Bacteroidetes,2FZND@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_983585_1 1479235.KK366039_gene2800 4.91e-19 86.3 COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,1S971@1236|Gammaproteobacteria,1XM57@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_983585_2 1255043.TVNIR_2888 2.82e-15 73.9 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_199129_1 522306.CAP2UW1_3983 8.16e-94 286.0 COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,2VMFB@28216|Betaproteobacteria 28216|Betaproteobacteria M FtsX-like permease family - - - - - - - - - - - - FtsX k59_559108_2 580332.Slit_1670 5.55e-37 135.0 COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,2W0RY@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - - k59_264313_1 675813.VIB_000066 1.4e-103 310.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1XSWN@135623|Vibrionales 135623|Vibrionales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_134153_1 1123393.KB891330_gene830 3.4e-86 265.0 COG0547@1|root,COG0547@2|Bacteria,1PWC3@1224|Proteobacteria,2WBX0@28216|Betaproteobacteria,1KSR4@119069|Hydrogenophilales 119069|Hydrogenophilales E Glycosyl transferase family, helical bundle domain - - - - - - - - - - - - Glycos_trans_3N k59_918764_1 1123354.AUDR01000015_gene436 3.85e-37 136.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,1KS7Y@119069|Hydrogenophilales 119069|Hydrogenophilales C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN k59_722277_1 1123228.AUIH01000077_gene3777 1.3e-19 84.0 2C9QX@1|root,32U54@2|Bacteria,1N6HR@1224|Proteobacteria,1SHPM@1236|Gammaproteobacteria,1XQ3T@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_722277_2 525897.Dbac_0469 5.16e-46 165.0 29WN3@1|root,30I8X@2|Bacteria,1R4H3@1224|Proteobacteria,42Q38@68525|delta/epsilon subdivisions,2WM8N@28221|Deltaproteobacteria,2M8K9@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_951253_1 443152.MDG893_16362 7.61e-18 87.4 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria,464AV@72275|Alteromonadaceae 1236|Gammaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD recD GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009338,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,AAA_30,UvrD_C_2 k59_134154_2 4081.Solyc01g007650.2.1 4.19e-31 109.0 2CQT8@1|root,2R5Q2@2759|Eukaryota,386GT@33090|Viridiplantae,3GUDY@35493|Streptophyta,44UFM@71274|asterids 35493|Streptophyta S Chloroplast protein precursor Ycf15 putative - - - - - - - - - - - - Ycf15 k59_493549_1 1123355.JHYO01000010_gene3459 3.43e-32 127.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,2VF2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_722279_1 1165841.SULAR_09149 1.91e-71 219.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,42RGH@68525|delta/epsilon subdivisions,2YP5E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_2174_1 1203605.HMPREF1531_01769 2.9e-16 79.0 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DN0X@85009|Propionibacteriales 201174|Actinobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - HHH_5,IMS,IMS_C,IMS_HHH k59_2174_2 1122947.FR7_2332 4.24e-112 337.0 COG1012@1|root,COG1012@2|Bacteria,1UHQT@1239|Firmicutes,4H8WF@909932|Negativicutes 909932|Negativicutes C Aldehyde dehydrogenase family - - 1.2.1.81 ko:K15515 - - - - ko00000,ko01000 - - - Aldedh k59_657318_1 391615.ABSJ01000026_gene110 2.86e-45 159.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1J6A4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria PT COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_395439_1 631362.Thi970DRAFT_04732 7.61e-56 184.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1WWC4@135613|Chromatiales 135613|Chromatiales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_35423_1 526222.Desal_2643 3.28e-43 150.0 COG0725@1|root,COG0725@2|Bacteria,1QD9D@1224|Proteobacteria,42QRE@68525|delta/epsilon subdivisions,2WMW0@28221|Deltaproteobacteria,2MD3P@213115|Desulfovibrionales 28221|Deltaproteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_787543_1 709032.Sulku_1861 4.55e-93 291.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,42MUY@68525|delta/epsilon subdivisions,2YMZF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E PFAM peptidase M3A and M3B thimet oligopeptidase F prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_362622_1 1168034.FH5T_07830 2.17e-115 366.0 COG1196@1|root,COG1196@2|Bacteria,4NF7P@976|Bacteroidetes,2FXCC@200643|Bacteroidia 976|Bacteroidetes D nuclear chromosome segregation - - - - - - - - - - - - DUF4175 k59_493560_1 880072.Desac_1143 2.07e-80 264.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MQB6@213462|Syntrophobacterales 28221|Deltaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_885340_1 765911.Thivi_1205 7.87e-38 146.0 COG0784@1|root,COG0834@1|root,COG2198@1|root,COG4251@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1X2QI@135613|Chromatiales 135613|Chromatiales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_166901_1 768671.ThimaDRAFT_1032 2.53e-114 355.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_657326_1 85643.Tmz1t_1738 1.99e-71 230.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,2KUMC@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_820323_1 1297581.H919_08540 4.28e-63 213.0 COG2189@1|root,COG2189@2|Bacteria,1TR8A@1239|Firmicutes,4HBP1@91061|Bacilli 91061|Bacilli L Adenine specific DNA methylase Mod mod - 2.1.1.72 ko:K00571,ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase,TypeIII_RM_meth k59_297202_1 1121937.AUHJ01000021_gene1432 3.32e-107 318.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,46BKC@72275|Alteromonadaceae 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_2186_1 1408303.JNJJ01000050_gene2102 3.27e-33 128.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4HA13@91061|Bacilli,1ZCMB@1386|Bacillus 91061|Bacilli E Aminotransferase aspB GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 ko:K00812,ko:K22457 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052 RC00006,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_2186_2 97096.XP_007790553.1 3.27e-06 48.5 COG0082@1|root,KOG4492@2759|Eukaryota,38EIY@33154|Opisthokonta,3NUJB@4751|Fungi,3QJS2@4890|Ascomycota,211M4@147550|Sordariomycetes 4751|Fungi E Chorismate synthase ARO2 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042602,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_722305_1 522306.CAP2UW1_3313 6.02e-69 220.0 COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2VRBW@28216|Betaproteobacteria 28216|Betaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_101341_2 886379.AEWI01000205_gene2390 8.27e-24 93.2 COG0234@1|root,COG0234@2|Bacteria,4NRE1@976|Bacteroidetes,2FTDY@200643|Bacteroidia,3XJZ8@558415|Marinilabiliaceae 976|Bacteroidetes O Chaperonin 10 Kd subunit - - - - - - - - - - - - Cpn10 k59_199174_1 768671.ThimaDRAFT_2616 2.42e-05 50.8 2CI39@1|root,32VJ3@2|Bacteria,1N3UR@1224|Proteobacteria,1SBDS@1236|Gammaproteobacteria,1WYYR@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_330272_1 1121106.JQKB01000015_gene5801 4.24e-86 269.0 COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2TSQJ@28211|Alphaproteobacteria,2JQW2@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF3422) - - - - - - - - - - - - DUF3422 k59_35449_1 95619.PM1_0201095 3.62e-99 311.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_362654_1 387093.SUN_1774 6.6e-31 114.0 COG0712@1|root,COG0712@2|Bacteria,1RFPY@1224|Proteobacteria,42SKR@68525|delta/epsilon subdivisions,2YPHX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_362654_2 1244083.CSUNSWCD_2140 9.14e-50 172.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2YMSF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iIT341.HP1134 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_2188_1 1565314.OA34_10675 3.89e-49 168.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,42RV8@68525|delta/epsilon subdivisions,2YPC0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_2188_2 1537917.JU82_07620 3.74e-15 70.5 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2YMNT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_885778_1 1454004.AW11_03116 9.03e-98 291.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2VHYC@28216|Betaproteobacteria,1KQVC@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U Binding-protein-dependent transport system inner membrane component potH - - ko:K11071,ko:K11075 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - - BPD_transp_1 k59_559686_2 526222.Desal_2200 5.46e-44 151.0 COG1225@1|root,COG1225@2|Bacteria,1MWFZ@1224|Proteobacteria,42SCA@68525|delta/epsilon subdivisions,2WP2G@28221|Deltaproteobacteria,2MCMW@213115|Desulfovibrionales 28221|Deltaproteobacteria O AhpC/TSA family - - - - - - - - - - - - AhpC-TSA k59_264765_2 338966.Ppro_1009 2.24e-60 201.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42T20@68525|delta/epsilon subdivisions,2WP7S@28221|Deltaproteobacteria,43W22@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_591507_1 572477.Alvin_0015 7.72e-64 219.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WX2G@135613|Chromatiales 135613|Chromatiales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_526910_1 1168034.FH5T_07455 4.72e-134 387.0 COG0191@1|root,COG0191@2|Bacteria,4NF5C@976|Bacteroidetes,2FNQM@200643|Bacteroidia 976|Bacteroidetes G Fructose-bisphosphate aldolase class-II fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_559689_1 795666.MW7_2140 2.03e-84 263.0 COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2VK8A@28216|Betaproteobacteria,1JZYP@119060|Burkholderiaceae 28216|Betaproteobacteria F Imidazolone-5-propionate hydrolase hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_199562_2 396588.Tgr7_1817 5.51e-22 94.0 COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,1RY8F@1236|Gammaproteobacteria,1WZYN@135613|Chromatiales 135613|Chromatiales E 4-Hydroxyphenylpyruvate dioxygenase - - - - - - - - - - - - - k59_984104_1 1123311.KB904460_gene808 1.39e-08 56.2 COG3039@1|root,COG3039@2|Bacteria,1TPFS@1239|Firmicutes,4H9V9@91061|Bacilli 91061|Bacilli L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_984104_2 556261.HMPREF0240_01867 1.17e-114 345.0 COG3039@1|root,COG3039@2|Bacteria,1TPFS@1239|Firmicutes,249JM@186801|Clostridia,36E38@31979|Clostridiaceae 186801|Clostridia L This gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_690144_1 1517681.HW45_25645 9.36e-42 155.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1SWH8@1236|Gammaproteobacteria,1XVAI@135623|Vibrionales 135623|Vibrionales I Phospholipase D. Active site motifs. - - - - - - - - - - - - PLDc_2 k59_919327_2 864051.BurJ1DRAFT_2239 3.4e-09 62.8 COG1361@1|root,COG2304@1|root,COG2931@1|root,COG2982@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,1KK67@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q TIGRFAM outer membrane adhesin like proteiin - - - - - - - - - - - - Cadherin_3,DUF4347,He_PIG,HemolysinCabind,VWA_2 k59_232486_1 1408473.JHXO01000007_gene851 2.65e-27 108.0 COG2992@1|root,COG2992@2|Bacteria 2|Bacteria S amidase activity bax - - ko:K03796 - - - - ko00000 - GH73 - Glucosaminidase k59_232486_2 572544.Ilyop_0614 3.59e-170 495.0 COG1164@1|root,COG1164@2|Bacteria,3797Y@32066|Fusobacteria 32066|Fusobacteria E oligoendopeptidase, M3 family - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_461646_1 570952.ATVH01000001_gene923 2.62e-29 127.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria,2JPKF@204441|Rhodospirillales 204441|Rhodospirillales M COG3264 Small-conductance mechanosensitive channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - DUF3772,MS_channel k59_722706_1 1279038.KB907337_gene663 6.35e-86 279.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,2JPN7@204441|Rhodospirillales 204441|Rhodospirillales L ATP-dependent helicase hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_722706_2 450851.PHZ_c3167 0.000191 47.8 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria,2KFBW@204458|Caulobacterales 204458|Caulobacterales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_199567_1 1168034.FH5T_06820 6.34e-76 254.0 COG1361@1|root,COG3209@1|root,COG3291@1|root,COG4386@1|root,COG5184@1|root,COG1361@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4386@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity - - - - - - - - - - - - CHU_C,DUF11,RCC1 k59_428256_1 3712.Bo01499s020.1 5.93e-20 87.0 2CYKI@1|root,2S503@2759|Eukaryota,37VZS@33090|Viridiplantae,3GKQM@35493|Streptophyta 35493|Streptophyta S Protein of unknown function (DUF2647) - - - - - - - - - - - - DUF2647 k59_951671_1 519989.ECTPHS_06752 3.35e-113 343.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1WW0Q@135613|Chromatiales 135613|Chromatiales EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_951671_2 529507.PMI2361 1.25e-15 79.7 COG3103@1|root,COG4991@2|Bacteria,1MX7M@1224|Proteobacteria,1RS74@1236|Gammaproteobacteria,3Z2K2@583|Proteus 1236|Gammaproteobacteria T sh3 domain protein ygiM GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - ko:K07184 - - - - ko00000 - - - SH3_3 k59_951671_3 2340.JV46_28200 0.0 1010.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1J5FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T GTP-binding protein TypA typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_951671_4 1049564.TevJSym_bh00170 4.28e-171 484.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1J5A8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the peptidase S33 family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_951671_5 402626.Rpic_0373 1.18e-57 184.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,2VR31@28216|Betaproteobacteria,1K3IP@119060|Burkholderiaceae 28216|Betaproteobacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_951671_6 317013.NY99_11950 3.05e-96 326.0 COG0840@1|root,COG5000@1|root,COG0840@2|Bacteria,COG5000@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X3KX@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_4 k59_951671_7 713586.KB900536_gene2346 1.99e-110 320.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1WVVY@135613|Chromatiales 135613|Chromatiales E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_951671_8 1049564.TevJSym_bh00230 3.76e-107 313.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1J5UD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_951671_9 765910.MARPU_00335 2.01e-135 388.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1WXHX@135613|Chromatiales 135613|Chromatiales E TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_951671_10 2340.JV46_18600 1.04e-153 435.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1J5IF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - ko:K01663,ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iYL1228.KPN_02481 His_biosynth k59_951671_11 443144.GM21_2073 1.94e-62 201.0 COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,43UMS@69541|Desulfuromonadales 28221|Deltaproteobacteria S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_951671_12 870187.Thini_2351 9.88e-48 155.0 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,460XU@72273|Thiotrichales 72273|Thiotrichales E PFAM phosphoribosyl-ATP pyrophosphohydrolase hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_951671_14 1335757.SPICUR_00350 9.7e-15 71.6 COG1826@1|root,COG1826@2|Bacteria 2|Bacteria U protein secretion tatB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_951671_15 2340.JV46_18640 6.24e-106 321.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1J4ZF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_951671_16 765912.Thimo_0094 4.38e-38 136.0 COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1S0ZZ@1236|Gammaproteobacteria,1WX12@135613|Chromatiales 135613|Chromatiales KT response regulator receiver - - - - - - - - - - - - PAS,PAS_9,Response_reg k59_951671_17 1049564.TevJSym_bb00310 1.04e-52 167.0 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity bigR - - ko:K03892,ko:K07721,ko:K22042,ko:K22491 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 k59_951671_18 1123367.C666_06030 1.19e-65 211.0 COG0730@1|root,COG0730@2|Bacteria,1R712@1224|Proteobacteria,2VIJA@28216|Betaproteobacteria,2KV6U@206389|Rhodocyclales 206389|Rhodocyclales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_951671_19 1238182.C882_2393 5.52e-13 68.6 COG2703@1|root,COG2703@2|Bacteria,1N8CP@1224|Proteobacteria,2UVS6@28211|Alphaproteobacteria,2JXCZ@204441|Rhodospirillales 204441|Rhodospirillales P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_951671_20 396588.Tgr7_1038 7.11e-72 230.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction protein - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - HDOD k59_951671_21 404589.Anae109_4500 1.7e-30 115.0 COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2YVIX@29|Myxococcales 28221|Deltaproteobacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_951671_22 1380358.JADJ01000003_gene4553 1.11e-30 112.0 COG3070@1|root,COG3070@2|Bacteria,1RDWD@1224|Proteobacteria,1S496@1236|Gammaproteobacteria 1236|Gammaproteobacteria K regulator of competence-specific genes sxy GO:0006355,GO:0006810,GO:0007154,GO:0008150,GO:0009290,GO:0009292,GO:0009294,GO:0009605,GO:0009889,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0015931,GO:0019219,GO:0019222,GO:0030420,GO:0031323,GO:0031326,GO:0031344,GO:0031346,GO:0031668,GO:0044087,GO:0044089,GO:0044093,GO:0044764,GO:0048518,GO:0048522,GO:0050657,GO:0050789,GO:0050794,GO:0050896,GO:0051027,GO:0051090,GO:0051091,GO:0051128,GO:0051130,GO:0051171,GO:0051179,GO:0051234,GO:0051252,GO:0051704,GO:0051716,GO:0060255,GO:0060491,GO:0065007,GO:0065009,GO:0071496,GO:0071702,GO:0071705,GO:0080090,GO:0098657,GO:1903506,GO:1903656,GO:1903658,GO:2000112,GO:2001141 - ko:K07343 - - - - ko00000 - - - TfoX_C,TfoX_N k59_951671_25 1123229.AUBC01000006_gene850 2.75e-76 251.0 2AJ9B@1|root,319UA@2|Bacteria,1NU4P@1224|Proteobacteria,2UQB8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1513) - - - - - - - - - - - - DUF1513 k59_951671_28 439235.Dalk_0299 1.32e-230 645.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WJKF@28221|Deltaproteobacteria,2MJD9@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_820796_1 604354.TSIB_1693 9.53e-52 173.0 COG0396@1|root,arCOG04236@2157|Archaea,2XT6T@28890|Euryarchaeota,2436F@183968|Thermococci 183968|Thermococci E ABC transporter - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_820796_2 373903.Hore_18100 2.01e-122 360.0 COG0719@1|root,COG0719@2|Bacteria,1UQS5@1239|Firmicutes,258I9@186801|Clostridia,3WANN@53433|Halanaerobiales 186801|Clostridia O SufBD protein - - - ko:K07033 - - - - ko00000 - - - UPF0051 k59_820796_3 592316.Pat9b_0389 0.000344 42.7 COG1082@1|root,COG1082@2|Bacteria,1NFRG@1224|Proteobacteria,1RPT9@1236|Gammaproteobacteria,3VY9R@53335|Pantoea 1236|Gammaproteobacteria G Xylose isomerase-like TIM barrel iolH - - ko:K06605 - - - - ko00000 - - - AP_endonuc_2 k59_68894_2 861454.HMPREF9099_01606 9.83e-70 221.0 COG1414@1|root,COG1414@2|Bacteria,1V7RD@1239|Firmicutes,24F4Z@186801|Clostridia,27P7J@186928|unclassified Lachnospiraceae 186801|Clostridia K helix_turn_helix isocitrate lyase regulation - - - - - - - - - - - - HTH_IclR,IclR k59_788061_1 387093.SUN_0385 6.11e-128 370.0 COG0583@1|root,COG0583@2|Bacteria,1R8CE@1224|Proteobacteria,42PKW@68525|delta/epsilon subdivisions,2YNJK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_101896_1 469616.FMAG_00431 3.07e-96 293.0 COG0679@1|root,COG0679@2|Bacteria,3798S@32066|Fusobacteria 32066|Fusobacteria S Auxin Efflux Carrier - - - - - - - - - - - - - k59_101896_2 545693.BMQ_0769 1.64e-36 126.0 COG1440@1|root,COG1440@2|Bacteria,1VADE@1239|Firmicutes,4HM5Q@91061|Bacilli,1ZIC3@1386|Bacillus 91061|Bacilli G transporter subunit IIB licB - 2.7.1.196,2.7.1.205 ko:K02760 ko00500,ko02060,map00500,map02060 M00275 R11170,R11172 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.3.2 - - PTS_IIB k59_101896_3 1408254.T458_27580 2.61e-164 477.0 COG1455@1|root,COG1455@2|Bacteria,1TP8D@1239|Firmicutes,4H9W2@91061|Bacilli,26SNV@186822|Paenibacillaceae 91061|Bacilli G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane licC - - ko:K02761 ko00500,ko02060,map00500,map02060 M00275 R11170,R11172 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.3.2 - iYO844.BSU38390 PTS_EIIC k59_101896_4 1123511.KB905860_gene2269 2.45e-266 738.0 COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes 1239|Firmicutes G Belongs to the glycosyl hydrolase 1 family - - 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT1 - Glyco_hydro_1 k59_101896_5 1120746.CCNL01000005_gene203 3.36e-26 102.0 COG2186@1|root,COG2186@2|Bacteria 2|Bacteria K Transcriptional regulator - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR k59_134685_1 1168034.FH5T_12900 2.35e-101 295.0 COG0098@1|root,COG0098@2|Bacteria,4NG1Z@976|Bacteroidetes,2FMI8@200643|Bacteroidia 976|Bacteroidetes J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_134685_2 1296415.JACC01000013_gene340 7.26e-19 79.0 COG1841@1|root,COG1841@2|Bacteria,4NUXV@976|Bacteroidetes,1I55H@117743|Flavobacteriia,2YK3P@290174|Aquimarina 976|Bacteroidetes J Ribosomal protein L30p/L7e rpmD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_134685_3 1168034.FH5T_12910 1.74e-76 231.0 COG0200@1|root,COG0200@2|Bacteria,4NNFQ@976|Bacteroidetes,2FSJF@200643|Bacteroidia 976|Bacteroidetes J binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_167511_1 522306.CAP2UW1_2186 3.79e-91 275.0 COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,2VZJ4@28216|Betaproteobacteria 28216|Betaproteobacteria P Polycystin cation channel - - - ko:K08714 - - - - ko00000,ko02000 1.A.1.14 - - Ion_trans k59_526937_1 706587.Desti_3348 1.63e-82 255.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,42MEN@68525|delta/epsilon subdivisions,2WIYF@28221|Deltaproteobacteria,2MRF9@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_820802_1 1122603.ATVI01000006_gene502 2.69e-27 107.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1X4XB@135614|Xanthomonadales 135614|Xanthomonadales NU assembly protein (PilN) pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_820802_2 1049564.TevJSym_bb00160 5.75e-70 218.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_199583_1 944547.ABLL_2113 6.69e-117 339.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2YMN4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HP ATP-binding protein - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_428265_1 382464.ABSI01000012_gene2198 7.05e-30 124.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C k59_134687_1 72664.XP_006404497.1 9.27e-49 157.0 COG0457@1|root,KOG1124@2759|Eukaryota,37TZH@33090|Viridiplantae,3GKZ9@35493|Streptophyta 35493|Streptophyta S Essential for the assembly of the photosystem I (PSI) complex. May act as a chaperone-like factor to guide the assembly of the PSI subunits ycf3 - - - - - - - - - - - TPR_1 k59_134687_2 3983.cassava4.1_029880m 5.04e-17 73.9 2CYY8@1|root,2S76X@2759|Eukaryota,37XC2@33090|Viridiplantae,3GM76@35493|Streptophyta 35493|Streptophyta S Photosystem I assembly protein Ycf3 - - - - - - - - - - - - - k59_35923_1 266264.Rmet_0831 2.7e-62 215.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,1K06F@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_755143_1 484019.THA_1994 5.19e-39 137.0 COG3476@1|root,COG3476@2|Bacteria 2|Bacteria T COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) tspO GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 - - - ko00000,ko00001,ko02000 9.A.24 - - TspO_MBR k59_395972_1 1249480.B649_05385 6.99e-102 311.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2YR9K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Synthesizes alpha-1,4-glucan chains using ADP-glucose - - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_395972_2 1232410.KI421412_gene319 2.75e-12 66.2 COG0297@1|root,COG0366@1|root,COG0297@2|Bacteria,COG0366@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,43U7I@69541|Desulfuromonadales 28221|Deltaproteobacteria G Starch synthase catalytic domain glgA-2 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Alpha-amylase,Glyco_transf_5,Glycos_transf_1 k59_885822_1 177437.HRM2_p00250 1.4e-33 133.0 COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHWA@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,Response_reg k59_564641_1 1288963.ADIS_1506 7.76e-79 260.0 2CHVP@1|root,2Z866@2|Bacteria,4NJWZ@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_172429_1 2340.JV46_27600 2.52e-92 281.0 COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,1RS3Q@1236|Gammaproteobacteria,1JB7K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S DMSO reductase anchor subunit (DmsC) dmsC - - ko:K21309 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - DmsC k59_1021851_1 176280.SE_1200 2.63e-10 67.0 COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,4H9ZR@91061|Bacilli,4GXC8@90964|Staphylococcaceae 91061|Bacilli L May be involved in recombinational repair of damaged DNA recN GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_74342_1 553218.CAMRE0001_0698 4.32e-103 320.0 COG4928@1|root,COG4928@2|Bacteria,1RBWH@1224|Proteobacteria,43BDT@68525|delta/epsilon subdivisions,2YQ3A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S KAP family P-loop domain - - - - - - - - - - - - KAP_NTPase k59_74342_2 1249480.B649_11095 1.42e-12 67.0 COG1502@1|root,COG1502@2|Bacteria,1R51A@1224|Proteobacteria,42PGS@68525|delta/epsilon subdivisions,2YNQ6@29547|Epsilonproteobacteria 68525|delta/epsilon subdivisions I ORF6N domain - - - - - - - - - - - - ORF6N k59_924384_1 1121904.ARBP01000012_gene1271 5.76e-90 282.0 COG0438@1|root,COG0438@2|Bacteria,4PKQN@976|Bacteroidetes,47K56@768503|Cytophagia 976|Bacteroidetes M PFAM glycogen synthase - - 2.4.1.11 ko:K00693 ko00500,ko01100,ko04151,ko04152,ko04910,ko04922,ko04931,map00500,map01100,map04151,map04152,map04910,map04922,map04931 - R00292 RC00005 ko00000,ko00001,ko01000,ko01003 - GT3 - Glycogen_syn k59_172432_2 1300345.LF41_816 1.21e-39 142.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1X36D@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_400431_1 367737.Abu_1643 3.18e-82 253.0 COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,42KZB@68525|delta/epsilon subdivisions,2YN63@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_336292_1 1178482.BJB45_02400 2.69e-86 263.0 COG4663@1|root,COG4663@2|Bacteria,1MUA1@1224|Proteobacteria,1RYNZ@1236|Gammaproteobacteria,1XHP3@135619|Oceanospirillales 135619|Oceanospirillales Q Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_759688_1 1049564.TevJSym_aq00430 9.96e-70 216.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1J6DN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 OSCP k59_759688_2 2340.JV46_17390 4.86e-52 169.0 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,1J5YT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664 ATP-synt_B k59_759688_3 1123393.KB891332_gene2797 1.97e-36 124.0 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,1KRWR@119069|Hydrogenophilales 119069|Hydrogenophilales C ATP synthase subunit C - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_759688_4 1415778.JQMM01000001_gene558 8.07e-130 377.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1J4Z2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 ATP-synt_A k59_759688_6 631362.Thi970DRAFT_03474 2.14e-120 354.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales 135613|Chromatiales K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_759688_7 1027273.GZ77_22020 1.9e-115 338.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1XHC3@135619|Oceanospirillales 135619|Oceanospirillales D Chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_759688_8 1125863.JAFN01000001_gene229 3.81e-12 64.3 2EH48@1|root,33AW7@2|Bacteria,1NIYU@1224|Proteobacteria,42XKK@68525|delta/epsilon subdivisions,2WSKU@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_759688_9 316273.XCV1537 2.57e-16 82.8 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,1X4JP@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA k59_759688_10 443152.MDG893_18252 5.79e-66 209.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,466SB@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_759688_11 870187.Thini_3341 7.42e-306 850.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,4604K@72273|Thiotrichales 72273|Thiotrichales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_759688_12 1049564.TevJSym_aq00320 6.7e-187 535.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1J4DQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_759688_13 765910.MARPU_16735 3e-220 628.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales 135613|Chromatiales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_759688_14 765910.MARPU_00005 1.39e-216 610.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales 135613|Chromatiales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_759688_15 2340.JV46_17130 6.68e-141 411.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1J4Z6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_759688_16 1499686.BN1079_02586 2.34e-69 228.0 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria 1236|Gammaproteobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_759688_17 765912.Thimo_0674 0.0 1116.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_759688_18 243231.GSU0802 1.69e-16 78.2 COG1028@1|root,COG1028@2|Bacteria,1RBGC@1224|Proteobacteria,42TP6@68525|delta/epsilon subdivisions,2WQAU@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_759688_20 1117647.M5M_18250 2.01e-61 189.0 COG2732@1|root,COG2732@2|Bacteria,1NNSG@1224|Proteobacteria,1SITD@1236|Gammaproteobacteria 1236|Gammaproteobacteria K (Barnase) inhibitor - - - - - - - - - - - - Barstar k59_759688_21 349124.Hhal_1223 5.17e-57 189.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales 135613|Chromatiales I PFAM Phospholipid glycerol acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_759688_22 1286106.MPL1_09250 8.31e-72 221.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,460Q1@72273|Thiotrichales 72273|Thiotrichales E D,D-heptose 1,7-bisphosphate phosphatase - - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like k59_759688_23 1049564.TevJSym_aq00120 1.45e-56 177.0 2F88A@1|root,340MG@2|Bacteria,1NXS1@1224|Proteobacteria,1SQ1P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphoribosyl-ATP pyrophosphohydrolase - - - - - - - - - - - - MazG k59_759688_24 396588.Tgr7_3255 2.48e-269 763.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales 135613|Chromatiales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_759688_25 1049564.TevJSym_aq00100 2.96e-196 547.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1J50F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J glycyl-tRNA synthetase, alpha subunit glyQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 tRNA-synt_2e k59_759688_26 1049564.TevJSym_aj00150 2.27e-35 125.0 2DSPU@1|root,33GZC@2|Bacteria,1NJ5W@1224|Proteobacteria,1SHAK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - PilZ k59_759688_28 1049564.TevJSym_aq00090 2.36e-202 565.0 COG0482@1|root,COG0482@2|Bacteria,1QV6H@1224|Proteobacteria,1RQSV@1236|Gammaproteobacteria 1236|Gammaproteobacteria J tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain - - - - - - - - - - - - ThiI,tRNA_Me_trans k59_759688_29 1026882.MAMP_02885 5.85e-26 97.8 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1SCFA@1236|Gammaproteobacteria,461H2@72273|Thiotrichales 72273|Thiotrichales O Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - TusA k59_759688_30 572477.Alvin_3001 5.01e-127 378.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales 135613|Chromatiales P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_759688_31 1049564.TevJSym_aq00060 1.47e-303 832.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1J4KI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_759688_32 550540.Fbal_0090 5.74e-18 86.3 2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1SCUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S penicillin-binding protein - - - - - - - - - - - - BiPBP_C,DUF4124 k59_759688_33 631362.Thi970DRAFT_02339 6.56e-124 368.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_759688_34 1049564.TevJSym_aq00030 4.07e-250 696.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_759688_35 1049564.TevJSym_aq00020 5e-55 176.0 2BE3G@1|root,327U6@2|Bacteria,1RI7X@1224|Proteobacteria,1S88B@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_759688_36 472759.Nhal_3538 6.49e-100 296.0 COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,1RRYH@1236|Gammaproteobacteria,1X059@135613|Chromatiales 135613|Chromatiales L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_759688_37 317025.Tcr_2046 3.05e-26 110.0 COG0412@1|root,COG0526@1|root,COG0412@2|Bacteria,COG0526@2|Bacteria,1RB6H@1224|Proteobacteria,1S2QN@1236|Gammaproteobacteria,460Z2@72273|Thiotrichales 72273|Thiotrichales CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,LGT k59_759688_38 396588.Tgr7_3279 6.59e-183 514.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales 135613|Chromatiales F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_759688_39 1049564.TevJSym_at00190 3.89e-66 206.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1J5X0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_759688_40 768671.ThimaDRAFT_2570 7e-130 381.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales 135613|Chromatiales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_759688_41 765912.Thimo_3673 1.37e-59 189.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales 135613|Chromatiales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_759688_42 1049564.TevJSym_at00240 1.05e-52 170.0 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,1S8ZI@1236|Gammaproteobacteria,1J72K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Rhodanese-related sulfurtransferase yibN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_759688_44 768671.ThimaDRAFT_2567 1.48e-52 168.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1WYHD@135613|Chromatiales 135613|Chromatiales K regulatory protein, arsR - - - - - - - - - - - - HTH_5 k59_759688_45 1149133.ppKF707_2069 7.4e-232 654.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1YEMU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_759688_46 1049564.TevJSym_at00270 1.24e-82 265.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1J4S5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG4942 Membrane-bound metallopeptidase envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - - - - - - - - - - Peptidase_M23 k59_759688_47 1049564.TevJSym_at00280 1.07e-187 536.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J4IS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_759688_48 1049564.TevJSym_at00290 9.25e-74 234.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,1J6T5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_759688_49 765914.ThisiDRAFT_0005 1.36e-69 216.0 COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,1RSBI@1236|Gammaproteobacteria,1WY2E@135613|Chromatiales 135613|Chromatiales S TIGRFAM DJ-1 family protein - - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_759688_50 252305.OB2597_12081 3.54e-42 152.0 COG0515@1|root,COG0515@2|Bacteria,1QVSB@1224|Proteobacteria,2TWKG@28211|Alphaproteobacteria 28211|Alphaproteobacteria KLT serine threonine protein kinase - - - - - - - - - - - - - k59_759688_51 1049564.TevJSym_at00390 5.64e-283 786.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1J4IR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 - ko:K03688 - - - - ko00000 - - iYL1228.KPN_04331 ABC1 k59_759688_52 768671.ThimaDRAFT_1560 2.1e-36 134.0 COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1WWJP@135613|Chromatiales 135613|Chromatiales S Sterol-binding domain protein - - - ko:K03690 - - - - ko00000 - - - SCP2 k59_630365_20 1049564.TevJSym_cb00030 9.02e-47 155.0 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,1S8XU@1236|Gammaproteobacteria,1J72N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG3030 Protein affecting phage T7 exclusion by the F plasmid fxsA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944 - ko:K07113 - - - - ko00000 - - - FxsA k59_630365_21 105422.BBPM01000039_gene783 1.24e-07 59.7 COG2755@1|root,COG2755@2|Bacteria,2GTSG@201174|Actinobacteria,2NH8B@228398|Streptacidiphilus 201174|Actinobacteria E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 k59_630365_23 1049564.TevJSym_cb00050 2.6e-250 716.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_630365_24 1121015.N789_13810 5.71e-22 95.1 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,1SASG@1236|Gammaproteobacteria,1X798@135614|Xanthomonadales 135614|Xanthomonadales CO COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA,Redoxin k59_630365_25 631362.Thi970DRAFT_01169 9.91e-59 186.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1WY3G@135613|Chromatiales 135613|Chromatiales E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_630365_26 1328313.DS2_05340 1.15e-53 173.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,466TN@72275|Alteromonadaceae 1236|Gammaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - iYL1228.KPN_03664 Biotin_lipoyl k59_630365_27 2340.JV46_09790 1.07e-264 731.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1J50W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Biotin carboxylase accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_630365_28 2340.JV46_09800 2.39e-102 308.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1J4VE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Ribosomal protein L11 methyltransferase prmA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_630365_30 95619.PM1_0204215 3.46e-128 375.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_630365_31 2340.JV46_22250 1.31e-20 85.9 COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1J6UC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters fis GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03557 ko05111,map05111 - - - ko00000,ko00001,ko03000,ko03036,ko03400 - - - HTH_8 k59_630365_32 1049564.TevJSym_ao00430 1.57e-310 853.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1J4DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Bifunctional purine biosynthesis protein PurH purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_630365_33 1219065.VPR01S_26_00070 1.94e-235 656.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1XT9Q@135623|Vibrionales 135623|Vibrionales F Belongs to the GARS family purD GO:0003674,GO:0003824,GO:0004637,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_630365_34 765912.Thimo_3524 4.86e-121 358.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1X2FT@135613|Chromatiales 135613|Chromatiales S PFAM Aminoglycoside phosphotransferase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_630365_35 765910.MARPU_01050 3.9e-177 538.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales 135613|Chromatiales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_630365_36 391615.ABSJ01000042_gene2213 2.26e-100 314.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1J4I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_630365_37 697282.Mettu_0022 1.2e-153 441.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1XEPY@135618|Methylococcales 135618|Methylococcales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_630365_39 765912.Thimo_3262 2.88e-127 370.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1WVWS@135613|Chromatiales 135613|Chromatiales T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_630365_40 314278.NB231_14036 4.84e-49 160.0 2AGHX@1|root,316QI@2|Bacteria,1RI7I@1224|Proteobacteria,1S8W9@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_630365_41 1049564.TevJSym_ao00170 3.21e-76 231.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1J69X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0019842,GO:0031406,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051870,GO:0051871,GO:0055114,GO:0070401,GO:0070402,GO:0072341,GO:0097159,GO:1901265,GO:1901363 1.5.1.3 ko:K00287,ko:K18590 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 br01600,ko00000,ko00001,ko00002,ko01000,ko01504 - - iECBD_1354.ECBD_3567,iECDH1ME8569_1439.ECDH1ME8569_0047,iECNA114_1301.ECNA114_0036,iEcDH1_1363.EcDH1_3551,iEcSMS35_1347.EcSMS35_0050,iG2583_1286.G2583_0050,iJN746.PP_5132,iNRG857_1313.NRG857_00250,iUMN146_1321.UM146_23020 DHFR_1 k59_630365_42 1149133.ppKF707_3352 4.64e-163 459.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,1YCUA@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2827,iAPECO1_1312.APECO1_3678,iBWG_1329.BWG_2562,iE2348C_1286.E2348C_3096,iEC042_1314.EC042_3024,iEC55989_1330.EC55989_3103,iECABU_c1320.ECABU_c31240,iECDH10B_1368.ECDH10B_2997,iECDH1ME8569_1439.ECDH1ME8569_2734,iECED1_1282.ECED1_3283,iECH74115_1262.ECH74115_4093,iECIAI1_1343.ECIAI1_2935,iECIAI39_1322.ECIAI39_3246,iECNA114_1301.ECNA114_2885,iECO103_1326.ECO103_3386,iECO111_1330.ECO111_3555,iECO26_1355.ECO26_3899,iECOK1_1307.ECOK1_3231,iECP_1309.ECP_2840,iECS88_1305.ECS88_3122,iECSE_1348.ECSE_3084,iECSF_1327.ECSF_2642,iECSP_1301.ECSP_3779,iECUMN_1333.ECUMN_3154,iECW_1372.ECW_m3069,iECs_1301.ECs3684,iEKO11_1354.EKO11_0914,iETEC_1333.ETEC_3014,iEcDH1_1363.EcDH1_0864,iEcE24377_1341.EcE24377A_3147,iEcSMS35_1347.EcSMS35_2974,iG2583_1286.G2583_3481,iJO1366.b2827,iJR904.b2827,iLF82_1304.LF82_2267,iNRG857_1313.NRG857_13965,iSSON_1240.SSON_2984,iUMN146_1321.UM146_02290,iUMNK88_1353.UMNK88_3511,iUTI89_1310.UTI89_C3229,iWFL_1372.ECW_m3069,iY75_1357.Y75_RS14705,iYL1228.KPN_03236,iZ_1308.Z4144,ic_1306.c3422 Thymidylat_synt k59_630365_43 765912.Thimo_2451 4.82e-133 384.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales 135613|Chromatiales M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_630365_45 946483.Cenrod_1456 1.84e-15 87.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,2VNEJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 k59_630365_47 338966.Ppro_1641 3.69e-29 111.0 2E3B5@1|root,32YAP@2|Bacteria,1N7KQ@1224|Proteobacteria,42W05@68525|delta/epsilon subdivisions,2WS7Z@28221|Deltaproteobacteria,43VK6@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF2721) - - - - - - - - - - - - DUF2721 k59_630365_48 270374.MELB17_01555 2.02e-46 155.0 COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,1S60I@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Domain of unknown function DUF302 - - - - - - - - - - - - Beta-lactamase,DUF302 k59_630365_49 765913.ThidrDRAFT_0351 2.24e-179 511.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1WX7X@135613|Chromatiales 135613|Chromatiales J SAM-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_630365_50 1089552.KI911559_gene1833 1.47e-32 122.0 COG1695@1|root,COG1695@2|Bacteria,1N33P@1224|Proteobacteria,2U9ZC@28211|Alphaproteobacteria,2JTEX@204441|Rhodospirillales 204441|Rhodospirillales K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR k59_630365_51 706587.Desti_5504 2.74e-09 66.2 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42PAC@68525|delta/epsilon subdivisions,2WKAD@28221|Deltaproteobacteria,2MRT5@213462|Syntrophobacterales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_630365_52 870187.Thini_3615 0.0 1157.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,4622X@72273|Thiotrichales 72273|Thiotrichales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_630365_53 1485545.JQLW01000011_gene1357 1.66e-57 186.0 COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria 1224|Proteobacteria S (twin-arginine translocation) pathway signal - - - - - - - - - - - - Ysc84 k59_630365_54 1049564.TevJSym_ao00080 5.86e-178 501.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G sugar kinase adoK - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_630365_55 1384056.N787_06040 8.86e-38 131.0 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1X70R@135614|Xanthomonadales 135614|Xanthomonadales M Recycling of diacylglycerol produced during the turnover of membrane phospholipid dgkA - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_630365_56 765912.Thimo_1681 1.43e-280 775.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P k59_764909_1 323261.Noc_1323 1.45e-20 93.6 2DBYQ@1|root,32TYF@2|Bacteria,1N2HM@1224|Proteobacteria,1SB6Y@1236|Gammaproteobacteria,1X1T1@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_602442_1 99598.Cal7507_5584 1.57e-33 125.0 COG0825@1|root,COG0825@2|Bacteria,1G0PY@1117|Cyanobacteria,1HJ7R@1161|Nostocales 1117|Cyanobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_602442_2 1319815.HMPREF0202_01474 5.69e-155 443.0 COG0205@1|root,COG0205@2|Bacteria,37841@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_602442_3 572544.Ilyop_1759 1.34e-247 690.0 COG0469@1|root,COG0469@2|Bacteria,378U8@32066|Fusobacteria 32066|Fusobacteria G Pyruvate kinase pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_470586_1 1120919.AUBI01000017_gene965 1.41e-17 85.9 COG0589@1|root,COG0589@2|Bacteria,1RCG7@1224|Proteobacteria,2U6TI@28211|Alphaproteobacteria,2JSIM@204441|Rhodospirillales 204441|Rhodospirillales T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_830510_1 1158294.JOMI01000001_gene1893 1.55e-84 258.0 COG1073@1|root,COG1073@2|Bacteria,4NFJZ@976|Bacteroidetes,2FMNP@200643|Bacteroidia 976|Bacteroidetes S COG COG1073 Hydrolases of the alpha beta superfamily - - - ko:K06889 - - - - ko00000 - - - AXE1,DLH,Peptidase_S15 k59_8551_2 1168034.FH5T_17375 6.2e-260 718.0 COG0153@1|root,COG0153@2|Bacteria,4NE0C@976|Bacteroidetes,2FNGC@200643|Bacteroidia 976|Bacteroidetes G Belongs to the GHMP kinase family. GalK subfamily galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_8551_3 1168034.FH5T_17385 1.26e-31 120.0 COG0738@1|root,COG0738@2|Bacteria,4NEPI@976|Bacteroidetes,2FP0B@200643|Bacteroidia 976|Bacteroidetes G Transporter, major facilitator family protein gluP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_602458_1 1304885.AUEY01000026_gene3555 1.25e-51 172.0 COG2267@1|root,COG2267@2|Bacteria,1N8UK@1224|Proteobacteria,43CRT@68525|delta/epsilon subdivisions,2X7ZE@28221|Deltaproteobacteria,2MKZI@213118|Desulfobacterales 28221|Deltaproteobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6 k59_111626_1 445973.CLOBAR_00354 5.11e-149 435.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,25RRG@186804|Peptostreptococcaceae 186801|Clostridia G Glycosyl hydrolase family 3 N terminal domain - - - - - - - - - - - - Glyco_hydro_3 k59_764929_1 391612.CY0110_25486 1.3e-20 97.4 COG0642@1|root,COG2202@1|root,COG3899@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1GD97@1117|Cyanobacteria,3KHHW@43988|Cyanothece 1117|Cyanobacteria T Serine Threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_9,Response_reg k59_505141_1 292415.Tbd_2145 2.93e-22 94.0 28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria,2VQVV@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_505141_2 1121861.KB899925_gene2554 1.76e-07 54.7 COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,2JQ14@204441|Rhodospirillales 204441|Rhodospirillales E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_699818_1 1004785.AMBLS11_05025 1.23e-76 240.0 COG3108@1|root,COG3108@2|Bacteria,1RAMQ@1224|Proteobacteria,1S35S@1236|Gammaproteobacteria,46AQ3@72275|Alteromonadaceae 1236|Gammaproteobacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_1026073_1 1249480.B649_09010 5.66e-15 72.0 28QM5@1|root,319KE@2|Bacteria,1Q3DZ@1224|Proteobacteria,42X5X@68525|delta/epsilon subdivisions,2YQT9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - Cytochrome_CBB3 k59_569426_1 391625.PPSIR1_08671 8.59e-79 243.0 COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,42SZ5@68525|delta/epsilon subdivisions,2WPP5@28221|Deltaproteobacteria,2YZUG@29|Myxococcales 28221|Deltaproteobacteria S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1 k59_78805_1 929558.SMGD1_1174 1.64e-89 273.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,42MF9@68525|delta/epsilon subdivisions,2YN3Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0005488,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0663 Chorismate_synt k59_635066_1 944547.ABLL_2114 2.92e-85 273.0 COG4774@1|root,COG4774@2|Bacteria,1QU2Y@1224|Proteobacteria,43CFU@68525|delta/epsilon subdivisions,2YTF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M PFAM TonB-dependent Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - TonB_dep_Rec k59_505154_1 572547.Amico_1843 5.03e-20 95.9 COG2206@1|root,COG2984@1|root,COG2206@2|Bacteria,COG2984@2|Bacteria,3TBWG@508458|Synergistetes 508458|Synergistetes T PFAM metal-dependent phosphohydrolase HD sub domain - - - - - - - - - - - - ABC_sub_bind,HD,PAS_9 k59_635072_1 452637.Oter_0894 4.17e-178 539.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae 414999|Opitutae E glutamate synthase - - 1.4.7.1 ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 - R00021,R10086 RC00006,RC00010 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_145413_1 765911.Thivi_2951 7.45e-47 157.0 COG3335@1|root,COG3335@2|Bacteria,1N5WI@1224|Proteobacteria,1S5TZ@1236|Gammaproteobacteria,1WZ05@135613|Chromatiales 135613|Chromatiales L COG3335 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_3 k59_146166_2 118797.XP_007468251.1 1.36e-74 248.0 COG0085@1|root,KOG0214@2759|Eukaryota 2759|Eukaryota K DNA-directed 5'-3' RNA polymerase activity rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043,ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_178684_1 1499967.BAYZ01000080_gene914 3.16e-17 86.3 COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria 2|Bacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_765766_1 1049564.TevJSym_bh00120 1.43e-25 101.0 2C5QF@1|root,31MIM@2|Bacteria,1QJDJ@1224|Proteobacteria,1THCP@1236|Gammaproteobacteria,1JAA3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4381) - - - - - - - - - - - - DUF4381 k59_831262_1 572544.Ilyop_1854 1.59e-54 184.0 COG0773@1|root,COG0773@2|Bacteria,3788J@32066|Fusobacteria 32066|Fusobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_831262_2 572544.Ilyop_1853 1.38e-142 409.0 COG0812@1|root,COG0812@2|Bacteria,3785T@32066|Fusobacteria 32066|Fusobacteria M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_831262_3 572544.Ilyop_1852 5.5e-129 375.0 COG1181@1|root,COG1181@2|Bacteria,378CP@32066|Fusobacteria 32066|Fusobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_538146_1 1121441.AUCX01000015_gene3461 1.13e-82 253.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42N9Z@68525|delta/epsilon subdivisions,2WIKQ@28221|Deltaproteobacteria,2M9HW@213115|Desulfovibrionales 28221|Deltaproteobacteria I PFAM 6-phosphogluconate dehydrogenase NAD-binding - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_896608_1 1286106.MPL1_10322 2.71e-16 74.7 COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,45ZW8@72273|Thiotrichales 72273|Thiotrichales O Alkyl hydroperoxide reductase - - - - - - - - - - - - AhpC-TSA k59_896608_2 697282.Mettu_1619 8.18e-115 340.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1XEHS@135618|Methylococcales 135618|Methylococcales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_668974_1 1121935.AQXX01000136_gene4076 3.97e-47 159.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1XK3H@135619|Oceanospirillales 135619|Oceanospirillales D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_342434_1 1433126.BN938_1561 1.98e-10 61.6 COG0339@1|root,COG0339@2|Bacteria,4NFYA@976|Bacteroidetes,2FNQV@200643|Bacteroidia,22U26@171550|Rikenellaceae 976|Bacteroidetes E Peptidase family M3 dcp - 3.4.15.5 ko:K01284 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_342434_2 1168034.FH5T_16455 3.74e-101 316.0 COG0072@1|root,COG0072@2|Bacteria,4NF5B@976|Bacteroidetes,2FNBF@200643|Bacteroidia 976|Bacteroidetes J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_962048_1 666685.R2APBS1_0424 5.5e-39 136.0 COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,1S2V3@1236|Gammaproteobacteria,1XAPS@135614|Xanthomonadales 135614|Xanthomonadales L May nick specific sequences that contain T G mispairs resulting from m5C-deamination - - - ko:K07458 - - - - ko00000,ko01000,ko03400 - - - Vsr k59_242744_1 1408473.JHXO01000013_gene561 5.29e-11 68.9 COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FX61@200643|Bacteroidia 976|Bacteroidetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_406112_1 1265505.ATUG01000002_gene2299 4.9e-47 156.0 COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,2MJM3@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase korC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_406112_2 933262.AXAM01000040_gene1218 1.49e-58 189.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,2MIEW@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Thiamine pyrophosphate - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_603322_1 394.NGR_c22210 0.000217 49.3 COG0667@1|root,COG0673@1|root,COG0667@2|Bacteria,COG0673@2|Bacteria,1R5SD@1224|Proteobacteria,2U1JH@28211|Alphaproteobacteria,4B783@82115|Rhizobiaceae 28211|Alphaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red,GFO_IDH_MocA k59_570112_1 572544.Ilyop_2847 1.78e-144 411.0 COG0175@1|root,COG0175@2|Bacteria,37C5C@32066|Fusobacteria 32066|Fusobacteria H sulfate adenylyltransferase subunit 2 - - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_570112_2 572544.Ilyop_2846 1.64e-19 82.0 COG1146@1|root,COG1146@2|Bacteria,37CDD@32066|Fusobacteria 32066|Fusobacteria C binding domain protein - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - Fer4_10 k59_342442_1 1166018.FAES_3351 6.4e-65 216.0 COG0493@1|root,COG0493@2|Bacteria,4NG9R@976|Bacteroidetes,47M2V@768503|Cytophagia 976|Bacteroidetes E TIGRFAM glutamate synthases, NADH NADPH, small subunit gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_307613_2 1090318.ATTI01000001_gene634 2.15e-19 93.2 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2K0NT@204457|Sphingomonadales 204457|Sphingomonadales MU RND efflux system, outer membrane lipoprotein - - - - - - - - - - - - OEP k59_668999_1 1158756.AQXQ01000011_gene890 5.6e-15 77.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales 135613|Chromatiales S PFAM Peptidoglycan-binding lysin domain - - - - - - - - - - - - LysM k59_765787_2 1319815.HMPREF0202_00972 5.01e-253 702.0 COG0166@1|root,COG0166@2|Bacteria,378M3@32066|Fusobacteria 32066|Fusobacteria G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_765787_3 572544.Ilyop_1894 1.15e-244 682.0 COG1362@1|root,COG1362@2|Bacteria,378B1@32066|Fusobacteria 32066|Fusobacteria E M18 family aminopeptidase - - - - - - - - - - - - Peptidase_M18 k59_506019_1 1500890.JQNL01000001_gene2007 1.09e-08 55.5 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1X4A7@135614|Xanthomonadales 135614|Xanthomonadales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_506019_2 279714.FuraDRAFT_0631 2.5e-61 202.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria 28216|Betaproteobacteria S permease - - - - - - - - - - - - AI-2E_transport k59_732247_2 379066.GAU_2857 3.6e-27 110.0 COG0183@1|root,COG0183@2|Bacteria,1ZSW1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thiolase, C-terminal domain - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_635866_1 1312959.KI914697_gene3241 2.5e-43 154.0 COG2801@1|root,COG2801@2|Bacteria,2I8Z0@201174|Actinobacteria 201174|Actinobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_438300_1 314265.R2601_18668 1.67e-122 372.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the GcvT family - - 1.5.8.3 ko:K00314 ko00260,ko01100,map00260,map01100 - R00611 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_342462_1 1500893.JQNB01000001_gene523 3.1e-21 97.4 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1X5JZ@135614|Xanthomonadales 135614|Xanthomonadales H porphyrin biosynthesis protein hemY - - ko:K02498 - - - - ko00000 - - - HemY_N k59_669009_1 929558.SMGD1_1283 3.33e-94 285.0 COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,42MQ9@68525|delta/epsilon subdivisions,2YTBB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Arginosuccinate synthase - - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - Arginosuc_synth,ThiI,tRNA_Me_trans k59_211144_1 1191523.MROS_0102 3.81e-37 127.0 COG4577@1|root,COG4577@2|Bacteria 2|Bacteria CQ ethanolamine catabolic process - - - ko:K04027 - - - - ko00000 - - - BMC k59_211144_2 439235.Dalk_5001 1.56e-17 79.0 COG4577@1|root,COG4577@2|Bacteria,1RH1U@1224|Proteobacteria,42U8T@68525|delta/epsilon subdivisions,2WQCF@28221|Deltaproteobacteria,2MNPB@213118|Desulfobacterales 28221|Deltaproteobacteria CQ BMC - - - ko:K04027 - - - - ko00000 - - - BMC k59_930216_1 999541.bgla_1g32000 4.85e-18 83.6 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,1K3R4@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family livM - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_242776_1 1304885.AUEY01000005_gene854 8.64e-39 138.0 COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2WNEN@28221|Deltaproteobacteria,2MK2I@213118|Desulfobacterales 28221|Deltaproteobacteria P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp k59_700646_1 387093.SUN_1569 6.78e-75 239.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,42M6T@68525|delta/epsilon subdivisions,2YMJD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_831310_2 572544.Ilyop_1545 1.75e-114 340.0 COG1940@1|root,COG1940@2|Bacteria,378B8@32066|Fusobacteria 32066|Fusobacteria GK Psort location Cytoplasmic, score 9.97 - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_930223_1 1396418.BATQ01000018_gene4135 4.74e-10 65.9 COG5414@1|root,COG5414@2|Bacteria,46VD3@74201|Verrucomicrobia 74201|Verrucomicrobia K histone acetyltransferase binding - - - - - - - - - - - - - k59_700650_1 1537917.JU82_06590 4.09e-111 330.0 COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,42MNX@68525|delta/epsilon subdivisions,2YME9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG0330 Membrane protease subunits stomatin prohibitin homologs - - - - - - - - - - - - Band_7 k59_538209_1 1168034.FH5T_15000 2.32e-71 227.0 COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,2FNV5@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_112370_1 290340.AAur_0768 9.47e-28 109.0 2BDAC@1|root,326YU@2|Bacteria,2HCIT@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_831314_1 570952.ATVH01000018_gene3314 4.6e-21 92.4 COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,2JT6Z@204441|Rhodospirillales 204441|Rhodospirillales O HupE / UreJ protein - - - ko:K03192 - - - - ko00000 - - - HupE_UreJ k59_79437_1 1168034.FH5T_06120 3.29e-151 447.0 COG0760@1|root,COG0760@2|Bacteria,4NDZZ@976|Bacteroidetes,2FN8C@200643|Bacteroidia 976|Bacteroidetes O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_2 k59_1026898_1 1353537.TP2_14550 2.25e-23 92.8 COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,2UFJJ@28211|Alphaproteobacteria,2XNIM@285107|Thioclava 28211|Alphaproteobacteria U function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex atpI - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_732271_1 1168034.FH5T_11915 3.06e-84 262.0 COG0773@1|root,COG0773@2|Bacteria,4NE1V@976|Bacteroidetes,2FM6G@200643|Bacteroidia 976|Bacteroidetes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_342485_1 1120980.JQKH01000003_gene386 7.19e-11 68.2 COG2304@1|root,COG2931@1|root,COG3115@1|root,COG3209@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3115@2|Bacteria,COG3209@2|Bacteria,1MU7T@1224|Proteobacteria,2VNQS@28216|Betaproteobacteria 28216|Betaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3,HemolysinCabind k59_146171_1 1049564.TevJSym_ag00680 3.38e-262 723.0 COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,1RYIC@1236|Gammaproteobacteria 1236|Gammaproteobacteria C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388,ko:K16885 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored,Pyr_redox_2 k59_146171_2 1049564.TevJSym_ag00690 0.0 1106.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,1S0DI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - ko:K16886 - - - - ko00000 - - - Fer4,FlpD,Pyr_redox_2 k59_312981_1 1185766.DL1_06320 4.35e-85 257.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,2XN25@285107|Thioclava 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family paaG - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_248457_2 525904.Tter_0021 3.92e-06 48.9 COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabB - 2.3.1.179,2.3.1.41 ko:K00647,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_184218_1 754477.Q7C_1240 1.21e-82 259.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,4604E@72273|Thiotrichales 72273|Thiotrichales JKL DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_800729_2 194439.CT1466 8.75e-28 108.0 COG4916@1|root,COG4916@2|Bacteria 2|Bacteria S TIR domain - - - - - - - - - - - - Mrr_cat,SIR2_2,TIR_2 k59_476877_1 1449050.JNLE01000003_gene3692 2.53e-125 369.0 COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia,36DZU@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 1 family bglC - 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT1 - Glyco_hydro_1 k59_706288_1 1255043.TVNIR_1957 3.24e-44 147.0 COG0838@1|root,COG0838@2|Bacteria 2|Bacteria C NADH dehydrogenase (ubiquinone) activity nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_869122_1 765911.Thivi_0061 2.64e-73 238.0 COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Universal stress protein family - - - ko:K07090 - - - - ko00000 - - - TauE,Usp k59_869122_2 765911.Thivi_0060 1.13e-32 115.0 2EGXE@1|root,329EB@2|Bacteria,1NIPX@1224|Proteobacteria,1SHV3@1236|Gammaproteobacteria,1X1VS@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_706289_1 1168034.FH5T_01475 6.06e-101 298.0 COG0331@1|root,COG0331@2|Bacteria,4NE1D@976|Bacteroidetes,2FM9P@200643|Bacteroidia 976|Bacteroidetes I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_1032373_1 929558.SMGD1_0628 8.88e-37 144.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2YMWR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_706292_1 1280953.HOC_18124 7.05e-91 287.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae 28211|Alphaproteobacteria C pyruvate flavodoxin ferredoxin oxidoreductase MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_706292_2 379066.GAU_2382 3.31e-91 277.0 COG1013@1|root,COG1013@2|Bacteria,1ZSWT@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_248469_1 234831.PSM_B0468 4.03e-54 179.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_312997_2 1165841.SULAR_06343 1.39e-07 56.2 COG4967@1|root,COG4967@2|Bacteria 2|Bacteria NU type IV pilus modification protein PilV ppdC - - ko:K02458,ko:K02671,ko:K02681 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15 - - N_methyl,T2SSppdC k59_184226_1 572544.Ilyop_0590 3.81e-33 121.0 COG4359@1|root,COG4359@2|Bacteria,37ACE@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - HAD,Put_Phosphatase k59_184226_2 572544.Ilyop_0589 9.48e-93 279.0 COG1187@1|root,COG1187@2|Bacteria,379AA@32066|Fusobacteria 32066|Fusobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_184226_3 469616.FMAG_01231 3.47e-66 207.0 COG1386@1|root,COG1386@2|Bacteria,378I6@32066|Fusobacteria 32066|Fusobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_706307_2 765911.Thivi_3088 3.89e-32 119.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1WW5V@135613|Chromatiales 135613|Chromatiales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_476894_1 857087.Metme_1888 1.08e-29 117.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDW6@135618|Methylococcales 135618|Methylococcales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_476894_2 477184.KYC_14100 1.46e-07 55.5 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2VKCK@28216|Betaproteobacteria,3T39E@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mdtA_2 - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_608807_1 709032.Sulku_0108 8.72e-44 146.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2YNX4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_608807_2 1249480.B649_00465 3.22e-46 163.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2YMDG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD k59_836838_1 572544.Ilyop_0866 5.18e-51 171.0 COG1354@1|root,COG1354@2|Bacteria,379QJ@32066|Fusobacteria 32066|Fusobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_836838_2 572544.Ilyop_0865 1.78e-146 421.0 COG0196@1|root,COG0196@2|Bacteria,378GM@32066|Fusobacteria 32066|Fusobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_836838_3 572544.Ilyop_0864 1.38e-33 124.0 COG1481@1|root,COG1481@2|Bacteria,378E3@32066|Fusobacteria 32066|Fusobacteria K May be required for sporulation - - - ko:K09762 - - - - ko00000 - - - HTH_WhiA,LAGLIDADG_WhiA,WhiA_N k59_543445_1 1123020.AUIE01000016_gene1982 2.9e-17 83.2 29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_543445_2 710421.Mycch_4888 6.24e-54 184.0 COG4992@1|root,COG4992@2|Bacteria,2GIYG@201174|Actinobacteria,234P4@1762|Mycobacteriaceae 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_511515_1 713587.THITH_10370 5.92e-101 303.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_737602_1 2340.JV46_08400 3.55e-29 117.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria,1J5AV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor oprC - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_84992_1 236097.ADG881_2807 1.09e-56 191.0 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,1S52W@1236|Gammaproteobacteria 1236|Gammaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_50589_1 944564.HMPREF9200_0894 1.78e-62 219.0 COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,4H359@909932|Negativicutes 909932|Negativicutes L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_50589_2 44689.DDB0217898 1.56e-58 200.0 COG0042@1|root,KOG2335@2759|Eukaryota,3XB2K@554915|Amoebozoa 554915|Amoebozoa J Dihydrouridine synthase (Dus) - - - - - - - - - - - - Dus k59_737605_1 870967.VIS19158_09987 3.39e-81 244.0 COG3415@1|root,COG3415@2|Bacteria,1R1WJ@1224|Proteobacteria,1T5CK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_118092_1 666510.ASAC_0525 3.23e-38 143.0 COG1032@1|root,arCOG01356@2157|Archaea 2157|Archaea C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM k59_800751_1 1250232.JQNJ01000001_gene667 1.62e-48 176.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,1HXFM@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_771454_1 1121015.N789_12450 4.32e-71 226.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,1X41E@135614|Xanthomonadales 135614|Xanthomonadales S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation - - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_641453_1 768671.ThimaDRAFT_1565 5.25e-34 136.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_2 k59_14662_3 1121033.AUCF01000030_gene170 4.94e-81 251.0 COG0730@1|root,COG0730@2|Bacteria,1MVA4@1224|Proteobacteria,2U2D5@28211|Alphaproteobacteria,2JX2H@204441|Rhodospirillales 204441|Rhodospirillales S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE k59_379444_1 306537.jk1531 3.48e-07 57.4 COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,22JR4@1653|Corynebacteriaceae 201174|Actinobacteria T Histidine kinase mprB GO:0000160,GO:0003674,GO:0003824,GO:0004721,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023052,GO:0035556,GO:0036211,GO:0040007,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07653 ko02020,map02020 M00460 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_967788_1 1410618.JNKI01000007_gene785 1.56e-10 63.5 COG3494@1|root,COG3494@2|Bacteria,1U1G6@1239|Firmicutes,4H2CZ@909932|Negativicutes 909932|Negativicutes S Psort location Cytoplasmic, score 8.96 - - - ko:K09949 - - - - ko00000 - - - DUF1009 k59_967788_2 1278306.KB906908_gene590 5.39e-42 151.0 COG1043@1|root,COG1043@2|Bacteria,378KQ@32066|Fusobacteria 32066|Fusobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_967788_3 469618.FVAG_00402 2.34e-61 192.0 COG0764@1|root,COG0764@2|Bacteria,37A80@32066|Fusobacteria 32066|Fusobacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_967788_4 572544.Ilyop_1115 4.34e-46 155.0 COG0774@1|root,COG0774@2|Bacteria,3794N@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_935376_2 1168034.FH5T_05010 1.1e-143 411.0 COG0809@1|root,COG0809@2|Bacteria,4NF2T@976|Bacteroidetes,2FMFT@200643|Bacteroidia 976|Bacteroidetes H Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_967792_2 498211.CJA_2802 3.07e-10 64.3 COG3117@1|root,COG3117@2|Bacteria,1NGCC@1224|Proteobacteria,1SGDP@1236|Gammaproteobacteria,1FHMZ@10|Cellvibrio 1236|Gammaproteobacteria S Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA lptC - - ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC k59_511520_2 387092.NIS_1826 2.12e-18 85.1 COG2143@1|root,COG2143@2|Bacteria,1NEN3@1224|Proteobacteria,42SXU@68525|delta/epsilon subdivisions,2YPR0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7 k59_511524_1 258052.JNYV01000001_gene97 4e-15 80.9 COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria 201174|Actinobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_737613_1 1116472.MGMO_45c00480 6.03e-15 73.2 COG3415@1|root,COG3415@2|Bacteria,1QIVY@1224|Proteobacteria,1TGS2@1236|Gammaproteobacteria,1XGGU@135618|Methylococcales 135618|Methylococcales L Homeodomain-like domain - - - - - - - - - - - - HTH_32 k59_511531_2 1411685.U062_00408 9.74e-08 55.1 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1J6PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_379455_1 933262.AXAM01000023_gene643 1.04e-84 270.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2MJ0A@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_675211_1 1537917.JU82_04005 3.5e-125 367.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2YMR3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_118755_1 1033802.SSPSH_003278 7.11e-90 293.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU General Secretion Pathway protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_902831_1 387093.SUN_1701 6.63e-122 371.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2YMN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA_synt_2f k59_738104_1 344747.PM8797T_13827 3.88e-43 155.0 COG3119@1|root,COG3119@2|Bacteria,2IYSH@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A - - - - - - - - - - - - Sulfatase k59_444545_1 385682.AFSL01000088_gene912 9.57e-93 300.0 COG1026@1|root,COG1026@2|Bacteria,4PJ9W@976|Bacteroidetes,2G279@200643|Bacteroidia,3XKNA@558415|Marinilabiliaceae 976|Bacteroidetes S Peptidase M16C associated - - - - - - - - - - - - M16C_assoc,Peptidase_M16_C k59_412277_1 860228.Ccan_09310 0.000829 44.3 COG1538@1|root,COG1538@2|Bacteria,4NDZK@976|Bacteroidetes,1HWRE@117743|Flavobacteriia,1EQ3K@1016|Capnocytophaga 976|Bacteroidetes M Efflux transporter, outer membrane factor lipoprotein, NodT family - - - - - - - - - - - - OEP k59_412277_2 1121923.GPUN_1630 1.53e-18 90.5 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,46CQ4@72275|Alteromonadaceae 1236|Gammaproteobacteria M Biotin-lipoyl like - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_935972_2 944547.ABLL_0029 2.21e-73 227.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42QWE@68525|delta/epsilon subdivisions,2YNG3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_249011_1 448385.sce6976 1.23e-41 156.0 COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria 2|Bacteria C ATP:ADP antiporter activity - - - ko:K01932,ko:K03301 - - - - ko00000,ko01000 2.A.12 - - Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC k59_1032902_1 395493.BegalDRAFT_2930 1.21e-54 177.0 COG0235@1|root,COG0235@2|Bacteria,1QAVF@1224|Proteobacteria,1RW3I@1236|Gammaproteobacteria,4628Z@72273|Thiotrichales 72273|Thiotrichales G PFAM Class II Aldolase and Adducin N-terminal domain - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II k59_902845_2 1123400.KB904766_gene2953 7.42e-10 61.2 COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,461AM@72273|Thiotrichales 72273|Thiotrichales U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_902845_3 572544.Ilyop_1269 6.02e-41 140.0 COG0811@1|root,COG0811@2|Bacteria,379FS@32066|Fusobacteria 32066|Fusobacteria U Transporter, MotA TolQ ExbB proton channel family protein - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_184849_1 765914.ThisiDRAFT_0776 2.15e-77 239.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1WX04@135613|Chromatiales 135613|Chromatiales D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_512188_1 756272.Plabr_3518 1.29e-34 132.0 COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,2IX8E@203682|Planctomycetes 203682|Planctomycetes O PA domain - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 k59_512188_2 857087.Metme_1888 1.13e-12 67.8 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDW6@135618|Methylococcales 135618|Methylococcales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_412282_1 1168034.FH5T_08670 1.17e-88 289.0 COG0060@1|root,COG0060@2|Bacteria,4NEYT@976|Bacteroidetes,2FM5R@200643|Bacteroidia 976|Bacteroidetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_869680_1 580332.Slit_0827 1.06e-08 56.6 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,44VFX@713636|Nitrosomonadales 1224|Proteobacteria C PFAM FAD linked oxidase domain protein glcD GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750 FAD-oxidase_C,FAD_binding_4 k59_869680_2 710685.MycrhN_4104 9.55e-17 80.5 COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria,234ZI@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the long-chain O-acyltransferase family - GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_706857_1 387093.SUN_1181 1.88e-58 187.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2YP4X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L methyltransferase rsmD - - - - - - - - - - - Cons_hypoth95 k59_609454_1 713586.KB900536_gene2678 6.01e-36 127.0 COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria 1236|Gammaproteobacteria T dksA traR - - - - - - - - - - - - zf-dskA_traR k59_544009_1 1514668.JOOA01000002_gene3090 8.63e-21 92.4 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WGEA@541000|Ruminococcaceae 186801|Clostridia C glutamate synthase gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_544009_2 1235835.C814_00685 1.7e-35 129.0 COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,3WGGC@541000|Ruminococcaceae 186801|Clostridia C domain protein nfnA - 1.18.1.2,1.19.1.1 ko:K00528,ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146,R10159 RC00065 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_642032_1 264731.PRU_1102 2.59e-27 108.0 COG0148@1|root,COG0148@2|Bacteria,4NF5M@976|Bacteroidetes,2FMNI@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_642032_3 1168034.FH5T_14615 3.75e-27 99.4 COG2345@1|root,COG2345@2|Bacteria,4NYUQ@976|Bacteroidetes,2FVNT@200643|Bacteroidia 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - - k59_642032_4 1168034.FH5T_14610 2.24e-121 348.0 COG0605@1|root,COG0605@2|Bacteria,4NDZ4@976|Bacteroidetes,2FNA0@200643|Bacteroidia 976|Bacteroidetes C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_968347_1 1232437.KL662015_gene1255 1.41e-06 55.8 COG2909@1|root,COG3187@1|root,COG2909@2|Bacteria,COG3187@2|Bacteria 2|Bacteria O response to heat - - - ko:K03668,ko:K03929 - - - - ko00000,ko01000 - CE10 - GerE,META k59_801350_1 1537915.JU57_07530 1.63e-78 244.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2YMPS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_217472_1 563040.Saut_2154 5.96e-32 113.0 2AJEY@1|root,31A0Z@2|Bacteria,1Q4KX@1224|Proteobacteria,4325F@68525|delta/epsilon subdivisions,2YSRD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_157697_1 1403819.BATR01000036_gene1127 5.14e-73 254.0 COG0178@1|root,COG0178@2|Bacteria,46SAF@74201|Verrucomicrobia,2ITHY@203494|Verrucomicrobiae 203494|Verrucomicrobiae L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - - - - - - - - - - ABC_tran k59_222199_1 1168034.FH5T_07060 6.76e-164 467.0 COG0686@1|root,COG0686@2|Bacteria,4NE8F@976|Bacteroidetes,2FP71@200643|Bacteroidia 976|Bacteroidetes C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_711859_1 493475.GARC_0080 7.7e-66 223.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,465DD@72275|Alteromonadaceae 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_874666_1 765911.Thivi_0540 9.24e-18 80.1 2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - - - - - - - - - - Cas6 k59_874666_2 2340.JV46_21580 3.38e-95 283.0 COG0457@1|root,COG0457@2|Bacteria,1R85G@1224|Proteobacteria,1S0MD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_123797_1 935557.ATYB01000014_gene4274 6.34e-114 345.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,4B81G@82115|Rhizobiaceae 28211|Alphaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1006282_1 177437.HRM2_30840 7.44e-71 229.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria,2MIGZ@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_581550_1 1120963.KB894502_gene1361 1.59e-104 317.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,2Q26G@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_449986_1 1537917.JU82_10900 1.49e-131 392.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2YM9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase - - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 k59_385396_1 604331.AUHY01000020_gene1902 6.89e-31 121.0 COG0675@1|root,COG0675@2|Bacteria,1WJ2V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L Probable transposase - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_549335_1 232721.Ajs_3939 7.53e-40 149.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,4AARG@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_549335_2 754477.Q7C_1416 3.54e-39 137.0 COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,1S6CC@1236|Gammaproteobacteria,46131@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_416898_1 112098.XP_008605960.1 2.33e-09 59.3 COG0523@1|root,KOG2743@2759|Eukaryota 2759|Eukaryota F ATP binding - - - - - - - - - - - - CobW_C,cobW k59_416898_2 1168034.FH5T_15080 8.39e-58 186.0 COG0730@1|root,COG0730@2|Bacteria,4NKPI@976|Bacteroidetes,2FSAZ@200643|Bacteroidia 976|Bacteroidetes S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_614425_1 1049564.TevJSym_ag00520 1.91e-41 145.0 COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,1S3KS@1236|Gammaproteobacteria,1JBXT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Cobalt uptake substrate-specific transmembrane region - - - - - - - - - - - - CbiM k59_1006293_2 313606.M23134_07601 2.64e-08 57.4 COG2008@1|root,COG2008@2|Bacteria,4NEIH@976|Bacteroidetes,47KXF@768503|Cytophagia 976|Bacteroidetes E Threonine aldolase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_518339_1 765912.Thimo_0780 1.95e-111 321.0 2DB76@1|root,2Z7JZ@2|Bacteria,1R41X@1224|Proteobacteria,1S1J8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k59_1006804_1 525898.Sdel_0979 2.02e-128 396.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YM96@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cmeF - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_712397_1 448385.sce3195 2.47e-36 141.0 COG0331@1|root,COG3321@1|root,COG0331@2|Bacteria,COG3321@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria,2YYQ3@29|Myxococcales 28221|Deltaproteobacteria I Acyl transferase domain - - 2.3.1.39 ko:K00645,ko:K15327,ko:K15329,ko:K15469 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - Acyl_transf_1 k59_743622_1 1128398.Curi_c00320 2.76e-91 274.0 COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,2487W@186801|Clostridia,269WM@186813|unclassified Clostridiales 186801|Clostridia L Integrase core domain - - - - - - - - - - - - HTH_21,rve k59_743622_2 1392487.JIAD01000001_gene1002 9.81e-20 86.7 COG3481@1|root,COG3481@2|Bacteria,1TPIU@1239|Firmicutes,248SS@186801|Clostridia,25VNH@186806|Eubacteriaceae 186801|Clostridia S Psort location Cytoplasmic, score yhaM - - ko:K03698 - - - - ko00000,ko01000,ko03019 - - - HD,tRNA_anti-codon k59_21027_1 927658.AJUM01000034_gene468 1.52e-28 111.0 2FFT5@1|root,347QA@2|Bacteria,4P5W2@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - DUF4398 k59_518346_1 1548151.LS70_08790 4.89e-54 186.0 COG3843@1|root,COG3843@2|Bacteria,1MVHF@1224|Proteobacteria,42R02@68525|delta/epsilon subdivisions,2YNXA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U relaxase - - - - - - - - - - - - Relaxase k59_158638_2 1484460.JSWG01000006_gene2744 1.2e-100 301.0 COG5309@1|root,COG5309@2|Bacteria,4NIVF@976|Bacteroidetes,1I014@117743|Flavobacteriia 976|Bacteroidetes G Glycosyl hydrolase - - - - - - - - - - - - Glyco_hydro_17 k59_91827_1 1168034.FH5T_18315 2.41e-244 677.0 COG0673@1|root,COG0673@2|Bacteria,4NIF1@976|Bacteroidetes,2FX47@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_222834_1 713587.THITH_12290 2.86e-76 231.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1RMZM@1236|Gammaproteobacteria,1X0TN@135613|Chromatiales 135613|Chromatiales H Probable molybdopterin binding domain - - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_417448_1 472759.Nhal_0556 6.25e-17 82.4 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1WX3X@135613|Chromatiales 135613|Chromatiales N PFAM ABC-type uncharacterised transport system - - - - - - - - - - - - ABC_transp_aux k59_417448_2 323261.Noc_2645 5.32e-13 70.1 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WXUC@135613|Chromatiales 135613|Chromatiales S ABC-type transport system involved in multi-copper enzyme maturation, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_124554_1 1454007.JAUG01000099_gene1374 5.63e-90 289.0 COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,1IP26@117747|Sphingobacteriia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug k59_582370_1 1122225.AULQ01000006_gene1081 4.14e-67 217.0 COG1538@1|root,COG1538@2|Bacteria,4NE4S@976|Bacteroidetes,1HXG4@117743|Flavobacteriia 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_973668_1 96561.Dole_1349 3.29e-25 105.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MJ42@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2 k59_973668_2 326427.Cagg_0647 2.19e-08 57.0 COG0745@1|root,COG2203@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - - - - - - - - - - - CHASE3,EAL,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_91833_1 395494.Galf_0490 2.25e-59 196.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,44V0G@713636|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_743641_1 1168034.FH5T_10755 1.25e-170 509.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,4NE1X@976|Bacteroidetes,2FMPX@200643|Bacteroidia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_482441_1 1249627.D779_1826 1.85e-78 259.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_647814_1 1537917.JU82_10180 2.33e-61 197.0 COG0697@1|root,COG0697@2|Bacteria,1PIFB@1224|Proteobacteria,42QAN@68525|delta/epsilon subdivisions,2YNGI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG integral membrane protein (DUF6 domain protein) - - - - - - - - - - - - EamA k59_647814_2 2340.JV46_16370 3.27e-16 75.1 COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria,1J766@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P involved in tolerance to divalent cations cutA GO:0003674,GO:0005488,GO:0005507,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840 - ko:K03926 - - - - ko00000 - - - CutA1 k59_647814_3 1165841.SULAR_09114 4.43e-97 290.0 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2YNYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Hemolysin tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_647814_4 1355368.JART01000023_gene1491 2.15e-09 58.5 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2YMFH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_386189_1 472759.Nhal_3108 1.98e-160 475.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_482442_1 1086011.HJ01_02512 1.47e-45 157.0 COG2220@1|root,COG2220@2|Bacteria,4NIWY@976|Bacteroidetes,1HXJA@117743|Flavobacteriia,2NV8Y@237|Flavobacterium 976|Bacteroidetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 k59_56671_1 1122212.AULO01000014_gene1219 5.11e-64 205.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales 135619|Oceanospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_56671_2 477228.YO5_05529 2.15e-79 241.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1Z219@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_254646_1 187272.Mlg_1964 1.06e-116 364.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_549890_1 1168034.FH5T_07885 5.57e-84 265.0 COG0457@1|root,COG0457@2|Bacteria,4NDVW@976|Bacteroidetes,2FMY8@200643|Bacteroidia 976|Bacteroidetes NU Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_417461_1 189753.AXAS01000075_gene6010 4.61e-95 292.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_190517_1 981384.AEYW01000018_gene3284 1.88e-116 368.0 COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,2TTSD@28211|Alphaproteobacteria,4NCZM@97050|Ruegeria 28211|Alphaproteobacteria L RNase_H superfamily - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,RNase_H_2 k59_450809_1 709032.Sulku_0374 2.64e-109 321.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2YMPY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_21086_1 1537917.JU82_10275 4.56e-90 271.0 COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,43DIT@68525|delta/epsilon subdivisions,2YTIZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DREV methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_908217_1 96561.Dole_1669 1.19e-70 219.0 COG2203@1|root,COG2203@2|Bacteria,1NBYK@1224|Proteobacteria,42NFX@68525|delta/epsilon subdivisions,2WM8H@28221|Deltaproteobacteria,2MIRU@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM GAF domain protein - - - - - - - - - - - - GAF,GAF_2 k59_743666_1 1249627.D779_0448 8.44e-28 102.0 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,1WZ9Q@135613|Chromatiales 135613|Chromatiales J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_417473_2 765912.Thimo_1841 1.17e-60 206.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1WXAB@135613|Chromatiales 135613|Chromatiales P TrkA-N domain - - - - - - - - - - - - Ion_trans_2,TrkA_N k59_615005_1 371042.NG99_19825 1.71e-16 79.0 2DMWM@1|root,32U4H@2|Bacteria,1N2SS@1224|Proteobacteria,1S9T8@1236|Gammaproteobacteria,3X6IH@551|Erwinia 1236|Gammaproteobacteria - - Z012_00645 - - - - - - - - - - - - k59_615005_2 1306406.ASHX01000002_gene5411 1.01e-84 262.0 COG0426@1|root,COG0426@2|Bacteria,2GJT6@201174|Actinobacteria 201174|Actinobacteria C Metallo-beta-lactamase superfamily - - - - - - - - - - - - Flavodoxin_1,Lactamase_B k59_615005_5 313596.RB2501_10927 2.37e-70 222.0 arCOG07533@1|root,2ZF5I@2|Bacteria,4NMWZ@976|Bacteroidetes,1II7Y@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4386) - - - - - - - - - - - - DUF4386 k59_615005_6 586413.CCDL010000001_gene1418 7.88e-11 58.2 29TPQ@1|root,30EXR@2|Bacteria,1UD42@1239|Firmicutes,4IDUW@91061|Bacilli,23N73@182709|Oceanobacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_615005_7 1408473.JHXO01000002_gene3931 4.41e-74 234.0 COG0604@1|root,COG0604@2|Bacteria,4NHHT@976|Bacteroidetes,2FR11@200643|Bacteroidia 976|Bacteroidetes C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_N_2,ADH_zinc_N_2 k59_842769_2 572544.Ilyop_1348 8.14e-54 172.0 COG0319@1|root,COG0319@2|Bacteria,379V1@32066|Fusobacteria 32066|Fusobacteria S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_21100_1 1121406.JAEX01000005_gene2882 4.37e-23 96.7 COG3677@1|root,COG3677@2|Bacteria,1RFKN@1224|Proteobacteria,42RGK@68525|delta/epsilon subdivisions,2WNW7@28221|Deltaproteobacteria,2M7QY@213115|Desulfovibrionales 28221|Deltaproteobacteria L Transposase zinc-ribbon domain - - - ko:K07488 - - - - ko00000 - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_842774_1 864073.HFRIS_001729 1.56e-63 208.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,473P1@75682|Oxalobacteraceae 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_875376_1 493475.GARC_1735 4.63e-149 445.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,4663U@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG4993 Glucose dehydrogenase exaA - 1.1.2.8,1.1.5.5,1.1.9.1 ko:K00114,ko:K17760,ko:K22473 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285,R09479 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3 k59_190552_1 387093.SUN_2127 4.3e-75 230.0 COG0494@1|root,COG0494@2|Bacteria,1QSQG@1224|Proteobacteria,42RR5@68525|delta/epsilon subdivisions,2YP9Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Nudix domain - - 3.6.1.45 ko:K08077 - - - - ko00000,ko01000 - - - NUDIX k59_386246_1 247634.GPB2148_1447 5.85e-90 292.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1S0K4@1236|Gammaproteobacteria,1J8UH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_158690_1 29730.Gorai.012G156400.1 6.9e-16 75.9 COG0654@1|root,KOG2614@2759|Eukaryota,37PQZ@33090|Viridiplantae,3GDSC@35493|Streptophyta 35493|Streptophyta C Zeaxanthin epoxidase, chloroplastic-like - - - - - - - - - - - - FAD_binding_3 k59_353999_1 1122604.JONR01000004_gene889 6.18e-103 330.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5MD@135614|Xanthomonadales 135614|Xanthomonadales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_842786_1 349520.PPE_03011 9.48e-135 427.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_56728_2 98439.AJLL01000087_gene3932 5.59e-44 163.0 COG0592@1|root,COG0592@2|Bacteria,1FZV5@1117|Cyanobacteria,1JIB5@1189|Stigonemataceae 1117|Cyanobacteria L DNA polymerase III beta subunit dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_56728_3 557436.Lreu_0001 1.8e-14 73.9 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,3F3YA@33958|Lactobacillaceae 91061|Bacilli L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_354001_1 96561.Dole_3226 3.71e-53 185.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42NCR@68525|delta/epsilon subdivisions,2WKMY@28221|Deltaproteobacteria,2MHTZ@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC transporter transmembrane region - - - ko:K06147,ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_973739_1 762982.HMPREF9442_01574 5.42e-07 55.5 COG2335@1|root,COG2335@2|Bacteria,4NH49@976|Bacteroidetes,2FPBD@200643|Bacteroidia 976|Bacteroidetes M Fasciclin domain - - - ko:K19519 - - - - ko00000,ko04516 - - - Fasciclin k59_712479_1 177437.HRM2_15410 7.07e-31 114.0 COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,42T2P@68525|delta/epsilon subdivisions,2WPQ3@28221|Deltaproteobacteria,2MKI3@213118|Desulfobacterales 28221|Deltaproteobacteria S Cupin superfamily (DUF985) - - - ko:K09705 - - - - ko00000 - - - Cupin_5 k59_1006889_1 1168034.FH5T_08755 3.35e-57 188.0 COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,2FM0N@200643|Bacteroidia 976|Bacteroidetes E 8-amino-7-oxononanoate synthase kbl - 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_680835_1 1236514.BAKL01000033_gene2840 3.14e-75 237.0 COG4935@1|root,COG4935@2|Bacteria,4NH8G@976|Bacteroidetes,2G16U@200643|Bacteroidia,4AVH5@815|Bacteroidaceae 976|Bacteroidetes O CotH kinase protein cotH - - - - - - - - - - - CotH k59_21140_1 1121930.AQXG01000008_gene148 1.66e-103 320.0 COG1249@1|root,COG1249@2|Bacteria,4NEMS@976|Bacteroidetes,1IP99@117747|Sphingobacteriia 976|Bacteroidetes C Pyridine nucleotide-disulphide oxidoreductase, dimerisation merA - 1.16.1.1 ko:K00520 - - - - ko00000,ko01000 - - - HMA,Pyr_redox_2,Pyr_redox_dim k59_21140_3 690850.Desaf_3786 6.48e-23 89.0 COG2608@1|root,COG2608@2|Bacteria,1R1IE@1224|Proteobacteria,43EI8@68525|delta/epsilon subdivisions,2X8G7@28221|Deltaproteobacteria 28221|Deltaproteobacteria P mercury ion transmembrane transporter activity - - - - - - - - - - - - - k59_875397_1 391615.ABSJ01000054_gene1381 2.99e-142 424.0 COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1J4MV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Short chain dehydrogenase - - - - - - - - - - - - NAD_binding_4,adh_short k59_875397_2 314287.GB2207_08196 3.69e-17 76.6 COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,1J772@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_423088_1 396588.Tgr7_0458 5.06e-21 96.7 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1WYS8@135613|Chromatiales 135613|Chromatiales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - HAMP,HEAT_2,Pkinase,sCache_3_2 k59_26599_1 1380354.JIAN01000005_gene2819 8.44e-104 311.0 COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4F0PD@85016|Cellulomonadaceae 201174|Actinobacteria E TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_228657_1 1255043.TVNIR_1957 1.41e-34 122.0 COG0838@1|root,COG0838@2|Bacteria 2|Bacteria C NADH dehydrogenase (ubiquinone) activity nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_228657_2 765914.ThisiDRAFT_1073 9.37e-49 159.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_718054_1 1304885.AUEY01000138_gene215 4.41e-114 342.0 COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,42NUH@68525|delta/epsilon subdivisions,2WISE@28221|Deltaproteobacteria,2MI4T@213118|Desulfobacterales 28221|Deltaproteobacteria Q PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_913821_1 713586.KB900536_gene1098 1.75e-73 233.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1WWRB@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_947527_1 1038859.AXAU01000002_gene681 4.81e-20 89.4 COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2TS7X@28211|Alphaproteobacteria,3JT68@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Alpha/beta hydrolase family ephA - - - - - - - - - - - Abhydrolase_1 k59_947527_2 1120956.JHZK01000042_gene3051 1.31e-11 64.7 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,1JQ5T@119043|Rhodobiaceae 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_718058_1 1149133.ppKF707_4743 2.46e-41 156.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1YE6K@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyltransferase,Aminotran_1_2,NAD_binding_4,PP-binding,Thioesterase k59_979512_1 338969.Rfer_1232 3.3e-129 383.0 COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,2VNMY@28216|Betaproteobacteria,4AGEE@80864|Comamonadaceae 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_620948_1 632335.Calkr_0624 1.7e-32 131.0 COG0863@1|root,COG1743@1|root,COG0863@2|Bacteria,COG1743@2|Bacteria,1TQWC@1239|Firmicutes,2492S@186801|Clostridia,42EXK@68295|Thermoanaerobacterales 186801|Clostridia L PFAM DNA methylase N-4 N-6 - - - - - - - - - - - - N6_N4_Mtase k59_812970_1 768671.ThimaDRAFT_2202 1.14e-25 110.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria,1WY2W@135613|Chromatiales 135613|Chromatiales L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1 k59_588198_2 1041826.FCOL_09875 3.32e-22 96.7 COG4974@1|root,COG4974@2|Bacteria,4NP7P@976|Bacteroidetes,1I3Y6@117743|Flavobacteriia,2P0FN@237|Flavobacterium 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_324564_2 1150621.SMUL_2613 2.64e-30 113.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,42N20@68525|delta/epsilon subdivisions,2YN0N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 k59_423104_1 395493.BegalDRAFT_0738 4.86e-21 92.8 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,45ZZX@72273|Thiotrichales 72273|Thiotrichales T response regulator receiver - - - - - - - - - - - - DUF229,HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_423104_2 1247649.D560_1161 1.22e-25 108.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,3T20G@506|Alcaligenaceae 28216|Betaproteobacteria T Histidine kinase ntrY - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8 k59_652981_1 709032.Sulku_0074 4.02e-20 87.4 COG0679@1|root,COG0679@2|Bacteria,1N5NC@1224|Proteobacteria,42PYE@68525|delta/epsilon subdivisions,2YMUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_652981_2 1165841.SULAR_10279 2.58e-19 87.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_260276_1 1168034.FH5T_22110 1.49e-121 361.0 COG0205@1|root,COG0205@2|Bacteria,4NIKT@976|Bacteroidetes,2FNYX@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_783587_1 935845.JADQ01000054_gene3554 2.93e-64 210.0 COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,26R27@186822|Paenibacillaceae 91061|Bacilli J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_913840_1 1048834.TC41_2414 2.11e-57 192.0 COG0675@1|root,COG0675@2|Bacteria,1TRNY@1239|Firmicutes,4HD8I@91061|Bacilli,2795V@186823|Alicyclobacillaceae 91061|Bacilli L Helix-turn-helix domain - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_359535_1 84531.JMTZ01000051_gene912 1.83e-35 135.0 COG1878@1|root,COG1878@2|Bacteria,1R8IH@1224|Proteobacteria,1S46Y@1236|Gammaproteobacteria,1X5VG@135614|Xanthomonadales 135614|Xanthomonadales S Putative cyclase - - - - - - - - - - - - Cyclase k59_359535_2 1224318.DT73_04150 5.39e-54 185.0 COG0697@1|root,COG0697@2|Bacteria,1PIF0@1224|Proteobacteria,1SF3G@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_359535_3 1515746.HR45_04575 4.4e-69 218.0 COG0010@1|root,COG0010@2|Bacteria,1MWZY@1224|Proteobacteria,1RS4R@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the arginase family - - 3.5.3.1 ko:K01476 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00134 R00551 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_324574_2 929558.SMGD1_2511 1.03e-18 84.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,42NEF@68525|delta/epsilon subdivisions,2YTM5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_423116_1 1313265.JNIE01000008_gene95 5.03e-38 142.0 COG2199@1|root,COG2770@1|root,COG2770@2|Bacteria,COG3706@2|Bacteria,2G439@200783|Aquificae 200783|Aquificae T Diguanylate cyclase - - - - - - - - - - - - GGDEF,Lactamase_B k59_588231_1 674977.VMC_26410 1.01e-35 134.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1XSXA@135623|Vibrionales 135623|Vibrionales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_97047_1 1168034.FH5T_00940 1.58e-308 852.0 COG3250@1|root,COG3250@2|Bacteria,4NESZ@976|Bacteroidetes,2FPDW@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_718101_1 1158318.ATXC01000001_gene686 8.57e-24 95.5 2CJXU@1|root,32ZPF@2|Bacteria,2G5CX@200783|Aquificae 200783|Aquificae S Ribbon-helix-helix domain - - - - - - - - - - - - RHH_3 k59_718101_2 1158345.JNLL01000001_gene1523 4.68e-27 101.0 COG2026@1|root,COG2026@2|Bacteria,2G5FP@200783|Aquificae 200783|Aquificae DJ Addiction module toxin, RelE StbE family - - - - - - - - - - - - ParE_toxin k59_718101_3 1121923.GPUN_0165 2.9e-12 70.1 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,464CU@72275|Alteromonadaceae 1236|Gammaproteobacteria O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032 AnmK k59_749106_1 396588.Tgr7_3234 3e-50 172.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1WWA9@135613|Chromatiales 135613|Chromatiales C PFAM FAD dependent oxidoreductase - - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO k59_1012330_1 1386089.N865_02815 4.09e-32 118.0 COG1694@1|root,COG1694@2|Bacteria,2IKRC@201174|Actinobacteria,4FHQX@85021|Intrasporangiaceae 201174|Actinobacteria S MazG-like family - - - - - - - - - - - - MazG,MazG-like k59_359565_1 1408473.JHXO01000007_gene858 1.1e-112 349.0 COG0542@1|root,COG0542@2|Bacteria,4NE1J@976|Bacteroidetes,2FNNW@200643|Bacteroidia 976|Bacteroidetes O ATPase family associated with various cellular activities (AAA) clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_1044642_2 1286632.P278_24380 4.92e-15 76.3 COG0591@1|root,COG0591@2|Bacteria,4NG2M@976|Bacteroidetes,1HZKP@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1012338_1 1304885.AUEY01000032_gene1991 8.04e-35 137.0 COG1578@1|root,COG1578@2|Bacteria,1R50K@1224|Proteobacteria,42Q0S@68525|delta/epsilon subdivisions,2WJ5M@28221|Deltaproteobacteria,2MIQ5@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function DUF89 - - - - - - - - - - - - DUF89 k59_653035_1 387093.SUN_2220 5.71e-86 271.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2YN0B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_260328_1 243233.MCA2543 9.49e-109 347.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1XE1A@135618|Methylococcales 135618|Methylococcales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_457580_1 1238182.C882_1059 1.38e-69 228.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2JPV0@204441|Rhodospirillales 204441|Rhodospirillales S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_291691_1 1232437.KL662010_gene1576 2.47e-109 331.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHXB@213118|Desulfobacterales 28221|Deltaproteobacteria S ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn k59_783610_1 1235803.C825_04207 1e-48 176.0 COG0383@1|root,COG0383@2|Bacteria,4NI6N@976|Bacteroidetes,2FQGF@200643|Bacteroidia 976|Bacteroidetes G COG COG0383 Alpha-mannosidase - - - - - - - - - - - - CBM-like,Glyco_hydro_38,Glyco_hydro_38C k59_228719_1 551275.KB899544_gene1571 1.23e-18 84.7 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2TSC9@28211|Alphaproteobacteria,43XMU@69657|Hyphomonadaceae 28211|Alphaproteobacteria J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_812994_2 1304885.AUEY01000053_gene155 5.33e-17 81.6 COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,42MAT@68525|delta/epsilon subdivisions,2WKY9@28221|Deltaproteobacteria,2MKB1@213118|Desulfobacterales 28221|Deltaproteobacteria KLT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,Peptidase_C14 k59_749159_1 7217.FBpp0114484 6.89e-31 125.0 COG2272@1|root,KOG1516@2759|Eukaryota,38D2A@33154|Opisthokonta,3BDJX@33208|Metazoa,3CTBY@33213|Bilateria,41TV5@6656|Arthropoda,3SKV9@50557|Insecta,44ZX0@7147|Diptera,45SE3@7214|Drosophilidae 33208|Metazoa G alpha/beta hydrolase fold CES5A GO:0003674,GO:0003824,GO:0004771,GO:0004806,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0005811,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006486,GO:0006629,GO:0006631,GO:0006637,GO:0006638,GO:0006639,GO:0006690,GO:0006692,GO:0006693,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006805,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009056,GO:0009058,GO:0009059,GO:0009062,GO:0009100,GO:0009101,GO:0009117,GO:0009150,GO:0009259,GO:0009410,GO:0009636,GO:0009888,GO:0009987,GO:0010468,GO:0010876,GO:0010984,GO:0012505,GO:0015850,GO:0015918,GO:0016042,GO:0016043,GO:0016054,GO:0016125,GO:0016126,GO:0016192,GO:0016289,GO:0016290,GO:0016298,GO:0016482,GO:0016787,GO:0016788,GO:0016790,GO:0019216,GO:0019222,GO:0019538,GO:0019626,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0030154,GO:0030301,GO:0030855,GO:0031323,GO:0031974,GO:0032365,GO:0032366,GO:0032367,GO:0032501,GO:0032502,GO:0032787,GO:0033036,GO:0033559,GO:0033865,GO:0033875,GO:0034032,GO:0034377,GO:0034378,GO:0034379,GO:0034641,GO:0034645,GO:0035383,GO:0036211,GO:0042221,GO:0043062,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043413,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044283,GO:0044421,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046165,GO:0046395,GO:0046459,GO:0046461,GO:0046464,GO:0046483,GO:0046486,GO:0046503,GO:0046907,GO:0047617,GO:0047619,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051186,GO:0051234,GO:0051239,GO:0051641,GO:0051649,GO:0051716,GO:0051791,GO:0052689,GO:0055086,GO:0060255,GO:0060429,GO:0065003,GO:0065005,GO:0065007,GO:0070013,GO:0070085,GO:0070887,GO:0071466,GO:0071702,GO:0071704,GO:0071825,GO:0071827,GO:0071840,GO:0072329,GO:0072521,GO:0080090,GO:0090119,GO:0090122,GO:0090207,GO:0090320,GO:0097006,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901568,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653 3.1.1.1,3.1.1.56,3.1.1.59,3.1.1.7,3.1.1.84 ko:K01044,ko:K01049,ko:K01063,ko:K03927,ko:K15743 ko00564,ko00981,ko00983,ko01100,ko04725,map00564,map00981,map00983,map01100,map04725 - R01026,R06728,R08149,R08150,R08220,R08249,R08251,R08255,R08258 RC00020,RC00041,RC00055,RC00162,RC00460,RC00461,RC00475,RC00476,RC00523,RC00962,RC02264 ko00000,ko00001,ko00537,ko01000 - CE10 - COesterase k59_26658_1 1254432.SCE1572_28450 1.45e-34 134.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42RS8@68525|delta/epsilon subdivisions,2WND0@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Group II intron maturase-specific domain protein - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - Cas_Cas1,GIIM,RVT_1 k59_457598_1 574966.KB898649_gene4 5.04e-45 159.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,1RN0N@1236|Gammaproteobacteria,1XH9J@135619|Oceanospirillales 135619|Oceanospirillales C Ubiquinol oxidase subunit II - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_947569_1 1122947.FR7_4587 3.78e-39 149.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes 1239|Firmicutes Q synthase - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_324637_1 1535422.ND16A_0875 5.24e-23 98.6 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,2Q61F@267889|Colwelliaceae 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_784249_1 252305.OB2597_15325 3.83e-11 65.1 COG2374@1|root,COG2374@2|Bacteria,1NTH6@1224|Proteobacteria,2TVN3@28211|Alphaproteobacteria,2PDHH@252301|Oceanicola 28211|Alphaproteobacteria L endonuclease - - - - - - - - - - - - Exo_endo_phos k59_292516_1 380358.XALC_2642 6.28e-10 57.4 2CG3T@1|root,2ZFS2@2|Bacteria,1PB4W@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_292516_3 380358.XALC_2640 1.36e-114 344.0 COG3704@1|root,COG3704@2|Bacteria,1N8DA@1224|Proteobacteria 1224|Proteobacteria U TrbL/VirB6 plasmid conjugal transfer protein - - - ko:K03201 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - TrbL k59_292516_6 395495.Lcho_0783 1.41e-63 211.0 COG1475@1|root,COG1475@2|Bacteria,1R634@1224|Proteobacteria,2VPF5@28216|Betaproteobacteria,1KN2S@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - KorB,KorB_C,ParBc k59_292516_7 1038922.PflQ2_0580 2.45e-49 164.0 2E672@1|root,330VM@2|Bacteria,1N961@1224|Proteobacteria,1SSIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial mobilisation protein (MobC) - - - - - - - - - - - - MobC k59_292516_8 582744.Msip34_2376 3.92e-75 243.0 COG3843@1|root,COG3843@2|Bacteria,1MVHF@1224|Proteobacteria,2VS34@28216|Betaproteobacteria 28216|Betaproteobacteria U relaxase - - - - - - - - - - - - Relaxase k59_292516_10 983548.Krodi_0094 2.34e-43 172.0 COG5635@1|root,COG5635@2|Bacteria,4NIRY@976|Bacteroidetes,1HZWA@117743|Flavobacteriia 976|Bacteroidetes T NACHT domain - - - - - - - - - - - - NACHT k59_292516_12 237368.SCABRO_00363 4.98e-96 301.0 COG3177@1|root,COG3177@2|Bacteria,2J1MI@203682|Planctomycetes 203682|Planctomycetes S Fic/DOC family - - - - - - - - - - - - DUF4172,Fic k59_292516_14 765911.Thivi_3022 4.85e-69 215.0 2BVU9@1|root,32G90@2|Bacteria,1RJ7Q@1224|Proteobacteria,1SPC7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_292516_15 765911.Thivi_3023 2.88e-27 108.0 2AXGI@1|root,31PG6@2|Bacteria,1R9JH@1224|Proteobacteria,1SHCZ@1236|Gammaproteobacteria,1X20F@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_848914_1 1286106.MPL1_12493 2.98e-63 206.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,45ZWG@72273|Thiotrichales 72273|Thiotrichales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - Fer4_14,HemN_C,Radical_SAM k59_27325_1 1165841.SULAR_09054 2.25e-33 127.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2YMR5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_27325_2 1165841.SULAR_09049 2.78e-28 105.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2YPGX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the Fur family fur GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_488769_1 290512.Paes_0726 1.02e-141 417.0 COG1236@1|root,COG1236@2|Bacteria,1FER3@1090|Chlorobi 1090|Chlorobi J PFAM beta-lactamase domain protein - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_980416_1 1121405.dsmv_0302 2.67e-81 256.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2MHTM@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_423953_1 311402.Avi_4089 3.72e-06 55.1 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,4B8T7@82115|Rhizobiaceae 28211|Alphaproteobacteria S protein conserved in bacteria tamB - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_292538_1 387093.SUN_1302 5.7e-09 57.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,43AER@68525|delta/epsilon subdivisions,2YR8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M TIGRFAM YD repeat protein - - - - - - - - - - - - RHS_repeat k59_881526_1 96561.Dole_0775 5.3e-52 181.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2MHY5@213118|Desulfobacterales 28221|Deltaproteobacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_325419_1 886293.Sinac_3549 5.42e-11 69.3 COG0515@1|root,COG0515@2|Bacteria,2IXXT@203682|Planctomycetes 203682|Planctomycetes KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1013069_1 1234364.AMSF01000018_gene1411 4.79e-43 151.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_980433_1 326298.Suden_1817 2.81e-75 244.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2YN0B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_784290_1 2340.JV46_23450 3.18e-85 264.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1J4QB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0281 Malic enzyme maeB - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_488805_1 411479.BACUNI_04066 3.97e-14 74.3 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FM2D@200643|Bacteroidia,4AK7X@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug k59_980447_1 177439.DP2874 1.41e-58 198.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42QM3@68525|delta/epsilon subdivisions,2WKI2@28221|Deltaproteobacteria,2MI4S@213118|Desulfobacterales 28221|Deltaproteobacteria M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_233717_2 926561.KB900623_gene961 4.94e-21 91.3 COG2826@1|root,COG2826@2|Bacteria,1TRSF@1239|Firmicutes,248IJ@186801|Clostridia,3WBJ5@53433|Halanaerobiales 186801|Clostridia L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_38,rve k59_985261_1 1184609.KILIM_090_00100 5.26e-115 335.0 COG0693@1|root,COG0693@2|Bacteria,2I8UU@201174|Actinobacteria 201174|Actinobacteria EGP ThiJ/PfpI family-like - - - - - - - - - - - - ThiJ_like k59_723772_1 469616.FMAG_01246 1.88e-30 124.0 COG0841@1|root,COG0841@2|Bacteria,378DQ@32066|Fusobacteria 32066|Fusobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_789208_1 387093.SUN_0228 1.17e-71 236.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2YMS1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhF - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_298604_1 1537917.JU82_11065 9.12e-90 266.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2YP4R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_298604_2 1249480.B649_06385 1.06e-16 75.9 COG0125@1|root,COG0125@2|Bacteria,1R98D@1224|Proteobacteria,43B5Z@68525|delta/epsilon subdivisions,2YP5N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_952662_1 396588.Tgr7_2295 8.45e-155 464.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_265855_1 265072.Mfla_0623 1.13e-14 71.2 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,2KMKJ@206350|Nitrosomonadales 206350|Nitrosomonadales S PFAM Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_265855_2 713586.KB900536_gene2702 6.21e-49 176.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1WWF7@135613|Chromatiales 135613|Chromatiales H TonB-dependent Receptor Plug - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_168856_1 1179773.BN6_67920 4e-107 325.0 COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria,4DXM5@85010|Pseudonocardiales 201174|Actinobacteria I acyl-CoA dehydrogenase - - 1.3.8.7,1.3.8.8 ko:K00249,ko:K00255 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_168856_2 626418.bglu_1g02020 3.97e-15 79.3 COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2VKHW@28216|Betaproteobacteria,1K0FC@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_723784_1 273121.WS0749 1.85e-67 219.0 COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1NTJT@1224|Proteobacteria,42NK8@68525|delta/epsilon subdivisions,2YNNU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM Cytochrome c, class I - - - - - - - - - - - - Cyt_bd_oxida_I,Cytochrome_CBB3 k59_985279_2 690850.Desaf_0281 1.74e-28 112.0 COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,43BM7@68525|delta/epsilon subdivisions,2X6ZD@28221|Deltaproteobacteria,2MH97@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM peptidase M48 Ste24p - - - - - - - - - - - - Peptidase_M48 k59_3268_1 1168034.FH5T_04275 3.27e-86 259.0 COG1216@1|root,COG1216@2|Bacteria,4NHH6@976|Bacteroidetes,2FM40@200643|Bacteroidia 976|Bacteroidetes S Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 k59_298613_1 929556.Solca_3818 5.51e-22 99.8 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - Guanylate_cyc,HTH_18,TPR_16,TPR_2,TPR_8 k59_560964_1 1122226.AUHX01000011_gene430 9.66e-33 125.0 COG0702@1|root,COG0702@2|Bacteria,4NEJF@976|Bacteroidetes,1HY1N@117743|Flavobacteriia 976|Bacteroidetes GM epimerase - - - - - - - - - - - - DUF2867,Epimerase,NAD_binding_10 k59_723788_1 228405.HNE_0356 4.94e-06 48.1 COG4319@1|root,COG4319@2|Bacteria,1RDBF@1224|Proteobacteria,2U7AM@28211|Alphaproteobacteria,43Y3X@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 k59_723788_2 1121012.AUKX01000052_gene2581 7.67e-70 225.0 COG1409@1|root,COG1409@2|Bacteria,4NKP0@976|Bacteroidetes,1HY1S@117743|Flavobacteriia,23H8T@178469|Arenibacter 976|Bacteroidetes S Calcineurin-like phosphoesterase - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Metallophos,SASA k59_723788_3 743722.Sph21_2557 3.51e-29 111.0 COG0412@1|root,COG0412@2|Bacteria,4NEUX@976|Bacteroidetes,1IPA9@117747|Sphingobacteriia 976|Bacteroidetes Q dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_397144_2 435590.BVU_3485 1.96e-05 54.3 COG3177@1|root,COG3177@2|Bacteria,4NV5G@976|Bacteroidetes,2FQU1@200643|Bacteroidia,4AVSW@815|Bacteroidaceae 976|Bacteroidetes L Fic/DOC family - - - - - - - - - - - - Fic k59_103316_1 572477.Alvin_1633 4.16e-17 77.8 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1WW1Q@135613|Chromatiales 135613|Chromatiales S Belongs to the WrbA family - - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_103316_2 1158756.AQXQ01000009_gene1040 2.26e-25 99.8 COG3308@1|root,COG3308@2|Bacteria,1N5UB@1224|Proteobacteria,1SAAJ@1236|Gammaproteobacteria,1X1QR@135613|Chromatiales 135613|Chromatiales S Predicted membrane protein (DUF2069) - - - - - - - - - - - - DUF2069 k59_103316_4 745411.B3C1_04685 9.21e-63 201.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1J6CU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the DnaA family. HdA subfamily hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_789236_1 1049564.TevJSym_af00420 5.16e-61 210.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1J56P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_789236_2 935567.JAES01000024_gene1469 1.78e-14 72.8 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1X3MV@135614|Xanthomonadales 135614|Xanthomonadales C dehydrogenase lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_3490_32 1049564.TevJSym_av00170 3.92e-274 757.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1J547@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616 tRNA-synt_1c k59_3490_33 1049564.TevJSym_av00160 0.0 954.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1J4EK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG0008 Glutamyl- and glutaminyl-tRNA synthetases glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_985899_1 1121012.AUKX01000002_gene3413 1.19e-203 573.0 COG2801@1|root,COG2801@2|Bacteria,4NHJD@976|Bacteroidetes,1IABF@117743|Flavobacteriia 976|Bacteroidetes L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_29,rve,rve_3 k59_37655_1 745411.B3C1_00230 1.94e-74 228.0 COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,1J5W4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S DoxX - - - - - - - - - - - - DoxX k59_37655_2 1248916.ANFY01000004_gene1880 2.78e-20 94.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2TVI9@28211|Alphaproteobacteria,2K2GU@204457|Sphingomonadales 204457|Sphingomonadales O CAAX prenyl protease N-terminal, five membrane helices - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_855379_1 927658.AJUM01000045_gene1 2.89e-60 193.0 COG2801@1|root,COG2801@2|Bacteria,4PJ74@976|Bacteroidetes,2G1E2@200643|Bacteroidia,3XKYB@558415|Marinilabiliaceae 976|Bacteroidetes L Integrase core domain - - - - - - - - - - - - - k59_855379_2 927658.AJUM01000045_gene2 1.3e-43 143.0 COG2963@1|root,COG2963@2|Bacteria,4NSUA@976|Bacteroidetes,2G29G@200643|Bacteroidia,3XKFP@558415|Marinilabiliaceae 976|Bacteroidetes L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_593315_1 1168034.FH5T_20485 2.27e-41 154.0 COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,2FM3C@200643|Bacteroidia 976|Bacteroidetes G Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_16,TPR_2,TPR_21,TPR_6,TPR_8 k59_495881_1 1537917.JU82_11570 8.61e-146 424.0 COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2YMWN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Potassium uptake protein ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_495881_2 367737.Abu_1288 7.22e-46 155.0 COG0569@1|root,COG0569@2|Bacteria,1N3KX@1224|Proteobacteria,43B42@68525|delta/epsilon subdivisions,2YT5U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C TrkA-N domain - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_N k59_561500_1 349124.Hhal_0599 1.95e-70 241.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1WWAA@135613|Chromatiales 135613|Chromatiales O peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 k59_561500_2 765913.ThidrDRAFT_1260 1.68e-135 389.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1WX1J@135613|Chromatiales 135613|Chromatiales I Enoyl- acyl-carrier-protein reductase NADH - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_561500_3 1049564.TevJSym_au00330 0.0 980.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1J5J7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle hbpA - - - - - - - - - - - SBP_bac_5 k59_561500_4 768671.ThimaDRAFT_2293 3.53e-177 500.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WXAY@135613|Chromatiales 135613|Chromatiales EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_561500_5 331678.Cphamn1_1862 1.13e-73 224.0 COG0607@1|root,COG0607@2|Bacteria,1FEK7@1090|Chlorobi 1090|Chlorobi P PFAM Rhodanese domain protein - - - - - - - - - - - - Rhodanese k59_561500_6 1121935.AQXX01000120_gene4849 1.68e-64 203.0 COG1714@1|root,COG1714@2|Bacteria 2|Bacteria S RDD family - - - - - - - - - - - - RDD k59_561500_8 1267005.KB911260_gene3483 2.39e-36 135.0 COG1376@1|root,COG1376@2|Bacteria,1MUAB@1224|Proteobacteria,2TTXM@28211|Alphaproteobacteria 28211|Alphaproteobacteria L ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD k59_561500_10 1049564.TevJSym_ab00650 9.24e-260 737.0 COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S serine threonine protein kinase ppkA - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - VWA,VWA_2 k59_561500_11 1049564.TevJSym_ab00640 1.08e-113 334.0 COG1136@1|root,COG1136@2|Bacteria,1RCXK@1224|Proteobacteria,1S7TZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria V abc transporter atp-binding protein attE - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_561500_12 1049564.TevJSym_ab00630 6.96e-173 495.0 COG0577@1|root,COG0577@2|Bacteria,1QRYR@1224|Proteobacteria,1S0ZU@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-type antimicrobial peptide transport system, permease component tagS - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_561500_13 765912.Thimo_1128 1.09e-157 450.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria,1WWKB@135613|Chromatiales 135613|Chromatiales S PFAM Radical SAM - - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_561500_14 765912.Thimo_1127 4.31e-213 591.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RP6X@1236|Gammaproteobacteria,1WWZ7@135613|Chromatiales 135613|Chromatiales O PFAM peptidase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_561500_15 998674.ATTE01000001_gene1094 1.23e-70 223.0 COG3738@1|root,COG3738@2|Bacteria,1RE1M@1224|Proteobacteria,1S44B@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09974 - - - - ko00000 - - - DUF1287 k59_561500_16 1249627.D779_2907 2.23e-116 345.0 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,1WVVX@135613|Chromatiales 135613|Chromatiales O PFAM peptidase - - - - - - - - - - - - Peptidase_U32 k59_561500_17 880073.Calab_1648 4.65e-58 184.0 COG4731@1|root,COG4731@2|Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2147) - - - - - - - - - - - - DUF2147 k59_561500_18 1049564.TevJSym_af00300 1.62e-73 224.0 2DS8H@1|root,32USH@2|Bacteria,1RCDN@1224|Proteobacteria 1224|Proteobacteria S Putative redox-active protein (C_GCAxxG_C_C) - - - - - - - - - - - - C_GCAxxG_C_C k59_756637_1 314287.GB2207_07866 0.000462 42.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1J4IU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases visC GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03184,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R06146,R08768,R08775 RC00046,RC01254 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_756637_2 351348.Maqu_3426 3.69e-57 194.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,464X1@72275|Alteromonadaceae 1236|Gammaproteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases ubiH GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008681,GO:0009058,GO:0009108,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03185,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R04989,R08768,R08773 RC00046,RC02670 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_02702,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECD_1391.ECD_02739,iEcHS_1320.EcHS_A3066 FAD_binding_3 k59_332697_1 1123514.KB905900_gene2216 9.46e-24 92.8 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,4618M@72273|Thiotrichales 72273|Thiotrichales K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_332697_2 1121923.GPUN_0153 2.31e-127 387.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,464Q0@72275|Alteromonadaceae 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_561505_1 1235457.C404_26095 1.37e-78 254.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,1K0XH@119060|Burkholderiaceae 28216|Betaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_463720_1 633149.Bresu_0904 2.99e-91 285.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2KGX9@204458|Caulobacterales 204458|Caulobacterales S pfam abc1 - - - - - - - - - - - - ABC1 k59_201336_1 1321778.HMPREF1982_02114 1.12e-16 77.8 COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,248UZ@186801|Clostridia 186801|Clostridia ET ABC transporter, substrate-binding protein, family 3 glnH1 - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_201336_2 60520.HR47_07580 1.29e-24 104.0 COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,4HAJ5@91061|Bacilli,3F4HA@33958|Lactobacillaceae 91061|Bacilli P ABC transporter glnP - - ko:K02029,ko:K02030,ko:K10036 ko02010,map02010 M00227,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.2 - - BPD_transp_1,SBP_bac_3 k59_169588_1 1408473.JHXO01000010_gene3625 4.5e-80 258.0 COG0243@1|root,COG0243@2|Bacteria,4NITD@976|Bacteroidetes 976|Bacteroidetes C Molybdopterin oxidoreductase - - 1.7.2.3,1.8.5.5 ko:K07812,ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.4,5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_169588_2 313603.FB2170_11551 4.15e-75 227.0 COG0437@1|root,COG0437@2|Bacteria,4NK7Y@976|Bacteroidetes,1I0UN@117743|Flavobacteriia 976|Bacteroidetes C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_11 k59_332705_1 1380355.JNIJ01000051_gene2211 3.03e-156 457.0 COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,2U0T4@28211|Alphaproteobacteria,3JRE4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C PFAM FAD linked oxidase domain protein - - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_495897_1 1165096.ARWF01000001_gene832 0.00014 44.7 COG0826@1|root,2ZFB1@2|Bacteria,1P5R2@1224|Proteobacteria 1224|Proteobacteria O peptidase activity - - - - - - - - - - - - - k59_495897_2 1120953.AUBH01000003_gene2104 3.76e-61 190.0 COG1943@1|root,COG1943@2|Bacteria,1N7RA@1224|Proteobacteria 1224|Proteobacteria L COG1943 Transposase and inactivated derivatives - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_756647_1 457412.RSAG_03400 1.59e-07 56.2 COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,24ARJ@186801|Clostridia,3WHQ7@541000|Ruminococcaceae 186801|Clostridia K GntR family araR - - ko:K02103 - - - - ko00000,ko03000 - - - GntR,Peripla_BP_3 k59_756647_2 526218.Sterm_4011 1.31e-75 238.0 COG1879@1|root,COG1879@2|Bacteria,3793S@32066|Fusobacteria 2|Bacteria G Periplasmic binding protein domain - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_789836_1 314285.KT71_02627 2.06e-49 178.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_593340_1 1165841.SULAR_07580 9.51e-118 345.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2YMNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_266438_1 4081.Solyc01g007640.2.1 3.81e-194 594.0 2CMQD@1|root,2QRDV@2759|Eukaryota,37QIN@33090|Viridiplantae,3GEA1@35493|Streptophyta,44PKI@71274|asterids 35493|Streptophyta C Plant protein of unknown function (DUF825) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009509,GO:0009532,GO:0009536,GO:0009570,GO:0009575,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 - - - - - - - - - - AAA,DUF825 k59_169596_1 1541065.JRFE01000012_gene2495 1.21e-74 241.0 COG3385@1|root,COG3385@2|Bacteria,1G2W3@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_299179_1 1168034.FH5T_05470 3.54e-46 167.0 COG1502@1|root,COG4085@1|root,COG1502@2|Bacteria,COG4085@2|Bacteria,4NVWC@976|Bacteroidetes,2FZM7@200643|Bacteroidia 976|Bacteroidetes I PLD-like domain - - - - - - - - - - - - PLDc_2 k59_756653_1 686340.Metal_1376 1.34e-08 63.2 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1XDTR@135618|Methylococcales 135618|Methylococcales G alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_985937_1 4081.Solyc01g007470.1.1 1.2e-21 87.4 COG0292@1|root,KOG4707@2759|Eukaryota,37VVT@33090|Viridiplantae,3GJCY@35493|Streptophyta 35493|Streptophyta J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rpl20 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006996,GO:0008150,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0031967,GO:0031975,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_299180_1 998088.B565_4010 3.24e-13 63.9 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1Y613@135624|Aeromonadales 135624|Aeromonadales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_299180_2 754477.Q7C_1918 1.15e-55 182.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,460DM@72273|Thiotrichales 72273|Thiotrichales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_953214_1 556267.HWAG_01611 8.97e-74 229.0 COG3736@1|root,COG3736@2|Bacteria,1MYE6@1224|Proteobacteria,43B80@68525|delta/epsilon subdivisions,2YT6N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U VirB8 protein - - - - - - - - - - - - VirB8 k59_822794_2 572544.Ilyop_0005 3.53e-29 107.0 2ECAP@1|root,33M19@2|Bacteria,37B78@32066|Fusobacteria 32066|Fusobacteria S Domain of unknown function (DUF370) - - - - - - - - - - - - DUF370 k59_822794_3 469618.FVAG_02463 7.9e-126 376.0 COG0187@1|root,COG0187@2|Bacteria,3789U@32066|Fusobacteria 32066|Fusobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_724407_1 1211813.CAPH01000012_gene315 1.63e-81 251.0 COG0042@1|root,COG0042@2|Bacteria,4NEN4@976|Bacteroidetes,2FM9Z@200643|Bacteroidia,22U6Z@171550|Rikenellaceae 976|Bacteroidetes J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - - - - - - - - - - Dus k59_691905_1 1249627.D779_1741 5.31e-40 153.0 28IUD@1|root,2Z8T4@2|Bacteria,1QZHS@1224|Proteobacteria,1RNTX@1236|Gammaproteobacteria,1WW4J@135613|Chromatiales 135613|Chromatiales S Carboxysome shell peptide mid-region - - - - - - - - - - - - CsoS2_M k59_659706_1 395493.BegalDRAFT_0648 4.59e-40 141.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,460Z3@72273|Thiotrichales 72273|Thiotrichales O Thiol disulfide interchange protein - - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA k59_1018863_1 933262.AXAM01000009_gene1495 9.09e-85 264.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2WJGT@28221|Deltaproteobacteria,2MICP@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_299189_1 749222.Nitsa_1860 8.5e-103 306.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2YM8U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_75696_1 573370.DMR_37480 2.37e-25 97.1 2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,42S33@68525|delta/epsilon subdivisions,2WNKG@28221|Deltaproteobacteria,2MC3F@213115|Desulfovibrionales 28221|Deltaproteobacteria S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - k59_990901_1 1417296.U879_08065 9.46e-75 224.0 COG2044@1|root,COG2044@2|Bacteria,1RGWS@1224|Proteobacteria,2UB97@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_238672_1 1249627.D779_2782 2e-30 115.0 COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,1RZC6@1236|Gammaproteobacteria,1WW50@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_238672_2 857087.Metme_3363 1.42e-33 127.0 COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,1S09S@1236|Gammaproteobacteria,1XG9D@135618|Methylococcales 135618|Methylococcales G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - - k59_892230_1 1120965.AUBV01000015_gene1100 2.9e-107 344.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47N25@768503|Cytophagia 976|Bacteroidetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_859214_1 1265505.ATUG01000001_gene4716 6.41e-68 211.0 COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,42UT4@68525|delta/epsilon subdivisions,2WQMN@28221|Deltaproteobacteria,2MP02@213118|Desulfobacterales 28221|Deltaproteobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_859214_2 1265505.ATUG01000001_gene4717 1.56e-06 48.9 COG5643@1|root,COG5643@2|Bacteria 2|Bacteria S FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - - - - - - - - - - - FmdE k59_41241_1 335543.Sfum_3077 3.31e-72 225.0 COG0558@1|root,COG0558@2|Bacteria,1N9TT@1224|Proteobacteria,42V2Q@68525|delta/epsilon subdivisions,2WRYY@28221|Deltaproteobacteria,2MSEQ@213462|Syntrophobacterales 28221|Deltaproteobacteria I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf,GtrA k59_696202_2 314292.VAS14_17841 8.47e-09 56.6 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1XTAV@135623|Vibrionales 135623|Vibrionales O COG1214 Inactive homolog of metal-dependent proteases tsaB - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_792461_1 1267535.KB906767_gene3086 0.00058 43.9 COG0500@1|root,COG2226@2|Bacteria,3Y7D3@57723|Acidobacteria 57723|Acidobacteria Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_25 k59_792461_2 1408473.JHXO01000005_gene1610 6.08e-93 276.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran k59_792461_3 1449335.JQLG01000004_gene1030 2.52e-54 179.0 COG1018@1|root,COG1018@2|Bacteria,1TREA@1239|Firmicutes,4HCF2@91061|Bacilli,27GSA@186828|Carnobacteriaceae 91061|Bacilli C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress - - - - - - - - - - - - FAD_binding_6,FAD_binding_8,NAD_binding_1 k59_467872_2 864051.BurJ1DRAFT_4367 7.43e-18 81.3 2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,2VVQC@28216|Betaproteobacteria 28216|Betaproteobacteria S Cytochrome P460 - - - - - - - - - - - - Cytochrome_P460 k59_108557_1 637905.SVI_1506 7.16e-26 105.0 COG1922@1|root,COG2148@1|root,COG1922@2|Bacteria,COG2148@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,2QAQA@267890|Shewanellaceae 1236|Gammaproteobacteria M TIGRFAM glycosyl transferase, WecB TagA CpsF family gumM - 2.4.1.187 ko:K05946,ko:K13660 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Bac_transf,Glyco_tran_WecB k59_108557_2 399549.Msed_1845 0.000344 46.2 COG1209@1|root,arCOG00667@2157|Archaea,2XPRJ@28889|Crenarchaeota 28889|Crenarchaeota M PFAM Nucleotidyl transferase rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_501007_1 572544.Ilyop_1333 2e-113 348.0 COG0465@1|root,COG0465@2|Bacteria,378CN@32066|Fusobacteria 32066|Fusobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_892240_1 563040.Saut_1804 4.49e-125 362.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2YMQ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_957446_1 1249480.B649_04785 3.97e-159 474.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2YMFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_760954_2 123899.JPQP01000020_gene1859 1.1e-14 74.7 2E8HH@1|root,332VP@2|Bacteria,1NACZ@1224|Proteobacteria,2WBW1@28216|Betaproteobacteria,3T6T7@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_303160_1 1117314.PCIT_07327 7.04e-05 43.9 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,2Q1IY@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Oligopeptidase A prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_303160_2 1288494.EBAPG3_16130 3.38e-21 92.0 2B1HQ@1|root,31TYQ@2|Bacteria,1MYSE@1224|Proteobacteria,2VTMU@28216|Betaproteobacteria,3731A@32003|Nitrosomonadales 28216|Betaproteobacteria S CNP1-like family - - - - - - - - - - - - CNP1 k59_990920_1 1123008.KB905700_gene2038 4.76e-81 253.0 COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,2FQNW@200643|Bacteroidia,22ZVG@171551|Porphyromonadaceae 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_337854_1 485918.Cpin_4545 3.12e-101 316.0 COG3533@1|root,COG3533@2|Bacteria,4P23R@976|Bacteroidetes 976|Bacteroidetes S Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - - k59_501016_1 1123326.JFBL01000021_gene2589 7.41e-93 299.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YM96@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cmeF - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_206382_1 326298.Suden_0006 6.78e-52 179.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_206382_2 1537917.JU82_05100 1.06e-76 237.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,42ME8@68525|delta/epsilon subdivisions,2YN4W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_696216_1 765912.Thimo_1740 1.24e-37 140.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_434042_1 1163398.AJJP01000030_gene232 3.16e-21 95.5 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_434042_2 2340.JV46_11660 3.75e-08 56.2 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1J4G3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0050896,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264 - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iG2583_1286.G2583_0058 OstA,OstA_C k59_696223_1 1049564.TevJSym_aa00990 3.25e-56 195.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1J55N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Chemotaxis protein histidine kinase cheA GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009892,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010605,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032101,GO:0032268,GO:0032269,GO:0032270,GO:0032879,GO:0032991,GO:0035303,GO:0035304,GO:0035306,GO:0035307,GO:0035556,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045937,GO:0046777,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051270,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0098561,GO:0140096,GO:1901564,GO:1901873,GO:1901875,GO:1902021,GO:2000145 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,CheY-binding,H-kinase_dim,HATPase_c,Hpt k59_664403_1 937777.Deipe_2101 4.74e-41 140.0 2BYEQ@1|root,32SXE@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_75726_1 1045855.DSC_04770 1.3e-33 134.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales 135614|Xanthomonadales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_859234_1 1249480.B649_09050 1.33e-152 459.0 COG0457@1|root,COG0457@2|Bacteria,1QV15@1224|Proteobacteria,42NKI@68525|delta/epsilon subdivisions,2YMKG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG0457 FOG TPR repeat pflB - - - - - - - - - - - TPR_16,TPR_2,TPR_6,TPR_8 k59_696224_1 318167.Sfri_2285 4.34e-22 89.0 COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,1S6BB@1236|Gammaproteobacteria,2QC1C@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM NADH-ubiquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_696224_2 318167.Sfri_2284 4.07e-143 413.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,2Q9B0@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM Na H antiporter MnhB subunit-related protein - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_631282_1 1168034.FH5T_06500 1.47e-117 345.0 COG2876@1|root,COG2876@2|Bacteria,4NDU4@976|Bacteroidetes,2FPF1@200643|Bacteroidia 976|Bacteroidetes E 3-deoxy-7-phosphoheptulonate synthase pheB - 5.4.99.5 ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,DAHP_synth_1 k59_631282_2 1168034.FH5T_06500 3.94e-40 142.0 COG2876@1|root,COG2876@2|Bacteria,4NDU4@976|Bacteroidetes,2FPF1@200643|Bacteroidia 976|Bacteroidetes E 3-deoxy-7-phosphoheptulonate synthase pheB - 5.4.99.5 ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,DAHP_synth_1 k59_598613_1 392500.Swoo_0898 1.17e-58 191.0 COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,1RMM9@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_337879_1 1121937.AUHJ01000050_gene1243 2.48e-201 565.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_664410_2 472759.Nhal_3988 1.96e-103 312.0 28JU3@1|root,2Z9J6@2|Bacteria,1RIGC@1224|Proteobacteria,1S7N4@1236|Gammaproteobacteria,1X0W6@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_664410_3 1317124.DW2_06823 2.63e-22 92.4 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,2XNEB@285107|Thioclava 28211|Alphaproteobacteria S Thioesterase-like superfamily ybgC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_206406_1 1122201.AUAZ01000008_gene426 1.92e-54 181.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,464DE@72275|Alteromonadaceae 1236|Gammaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_206406_2 1049564.TevJSym_ar00100 7.43e-10 57.8 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1J637@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_827074_1 572544.Ilyop_0517 1.45e-62 197.0 COG4123@1|root,COG4123@2|Bacteria,378T2@32066|Fusobacteria 32066|Fusobacteria S Putative RNA methylase family UPF0020 - - 2.1.1.172 ko:K00564 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - MTS,Methyltransf_31 k59_631292_1 1499967.BAYZ01000156_gene565 1.33e-50 171.0 COG0407@1|root,COG0407@2|Bacteria 2|Bacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_108600_1 1165841.SULAR_08864 1.74e-67 209.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,42RMF@68525|delta/epsilon subdivisions,2YP6U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_108600_2 387093.SUN_0520 7.2e-29 112.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2YME3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P sulfate adenylyltransferase sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_141735_1 765912.Thimo_0062 2.72e-17 81.6 2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1S5Q0@1236|Gammaproteobacteria,1WY9R@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_206413_1 1122164.JHWF01000007_gene1051 1.63e-136 397.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1JCHB@118969|Legionellales 118969|Legionellales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_859261_1 1049564.TevJSym_bn00140 1.88e-17 81.6 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1J8GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Amidohydrolase family pyrC - 3.5.2.3,3.5.2.5 ko:K01465,ko:K01466 ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120 M00051,M00546 R01993,R02425 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_859261_2 631362.Thi970DRAFT_02219 1.42e-41 151.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales 135613|Chromatiales E PFAM Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_566102_1 399742.Ent638_0216 1.49e-87 276.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,3X220@547|Enterobacter 1236|Gammaproteobacteria F Bifunctional purine biosynthesis protein PurH purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_173920_1 500632.CLONEX_00944 3.73e-51 167.0 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia 186801|Clostridia J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_173920_2 743719.PaelaDRAFT_5400 1.63e-20 85.9 COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,4HIGF@91061|Bacilli,26XMJ@186822|Paenibacillaceae 91061|Bacilli J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_467920_1 1165841.SULAR_09204 6.96e-53 179.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,42RJN@68525|delta/epsilon subdivisions,2YP6V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Divergent polysaccharide deacetylase - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_369971_1 572544.Ilyop_0543 1.68e-153 466.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,378RN@32066|Fusobacteria 32066|Fusobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_206422_1 666509.RCA23_c13130 2.78e-112 332.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L InterPro IPR001584 COGs COG2801 - - - - - - - - - - - - HTH_29,rve k59_108613_1 326298.Suden_0045 7.76e-27 108.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,42P57@68525|delta/epsilon subdivisions,2YMGG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_108613_2 709032.Sulku_0059 7.85e-65 203.0 COG1714@1|root,COG1714@2|Bacteria,1N2TA@1224|Proteobacteria 1224|Proteobacteria S RDD family - - - - - - - - - - - - RDD k59_108613_3 1172190.M947_08015 1.71e-31 114.0 COG3829@1|root,COG3829@2|Bacteria,1NG3B@1224|Proteobacteria,43AE4@68525|delta/epsilon subdivisions,2YT0Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT PAS sensor protein - - - - - - - - - - - - PAS,PAS_3 k59_566107_1 572544.Ilyop_0472 2.15e-82 254.0 COG2508@1|root,COG2508@2|Bacteria 2|Bacteria QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30,PucR k59_892311_1 563040.Saut_1004 9.46e-103 310.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2YNG4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_728497_1 2340.JV46_21830 2.93e-17 78.2 2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1J6SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4426) PP5099 - - - - - - - - - - - DUF4426 k59_728497_2 1198232.CYCME_0044 3.71e-20 86.3 COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,1S24V@1236|Gammaproteobacteria,460IK@72273|Thiotrichales 72273|Thiotrichales Q Methionine biosynthesis protein MetW - - - - - - - - - - - - MetW k59_631329_1 768671.ThimaDRAFT_0907 6.64e-48 160.0 COG1277@1|root,COG1277@2|Bacteria,1MWUZ@1224|Proteobacteria,1RQFG@1236|Gammaproteobacteria,1X1TK@135613|Chromatiales 135613|Chromatiales S ABC-2 family transporter protein - - - ko:K19341 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC2_membrane_2 k59_631329_2 768671.ThimaDRAFT_0908 7.51e-68 213.0 COG4314@1|root,COG4314@2|Bacteria,1N3G0@1224|Proteobacteria,1SPJU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C NosL - - - - - - - - - - - - NosL k59_141766_1 1225184.ALXE01000021_gene2600 4.61e-18 90.1 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,3VXPH@53335|Pantoea 1236|Gammaproteobacteria S With LptABCF is involved in the transport of lipopolysaccharides lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_598666_1 706587.Desti_5556 2.65e-12 66.2 COG0688@1|root,COG0688@2|Bacteria,1NNH6@1224|Proteobacteria,42YJ1@68525|delta/epsilon subdivisions,2WTZP@28221|Deltaproteobacteria,2MR4E@213462|Syntrophobacterales 28221|Deltaproteobacteria I Phosphatidylserine decarboxylase - - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_598666_2 1122212.AULO01000010_gene211 9.83e-19 80.9 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1XHB3@135619|Oceanospirillales 135619|Oceanospirillales I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_664450_1 749222.Nitsa_0162 1.9e-110 337.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2YM9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase - - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 k59_75782_1 748247.AZKH_4494 5.31e-57 193.0 COG3258@1|root,COG3258@2|Bacteria 2|Bacteria C Cytochrome c soxA GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005507,GO:0005515,GO:0005575,GO:0005623,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019418,GO:0019538,GO:0020037,GO:0022900,GO:0032991,GO:0036211,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0070069,GO:0071704,GO:0097159,GO:0098822,GO:1901363,GO:1901564 1.8.2.2 ko:K00406,ko:K03889,ko:K17222,ko:K19713 ko00190,ko00920,ko01100,ko01120,ko02020,map00190,map00920,map01100,map01120,map02020 M00151,M00156,M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - - k59_598671_1 1502851.FG93_02765 1.29e-50 179.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,3JU26@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_173958_1 1462527.CCDM010000001_gene2004 4.49e-77 244.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,23J9M@182709|Oceanobacillus 1239|Firmicutes G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_892334_1 1348635.BBJY01000015_gene742 2.52e-21 85.1 COG0633@1|root,COG0633@2|Bacteria,1QU91@1224|Proteobacteria,1T1VI@1236|Gammaproteobacteria,1XXYP@135623|Vibrionales 135623|Vibrionales C COG0633 Ferredoxin - - - ko:K11107 - - - - ko00000 - - - Fer2 k59_892334_2 675817.VDA_003182 3.44e-86 266.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria,1XVNI@135623|Vibrionales 135623|Vibrionales L Transposase and inactivated - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_75785_1 1319815.HMPREF0202_00053 2.53e-150 431.0 COG0709@1|root,COG0709@2|Bacteria,379T4@32066|Fusobacteria 32066|Fusobacteria H Selenide, water dikinase selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k59_75785_2 596329.HMPREF0631_1630 0.000928 42.4 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,25R1M@186804|Peptostreptococcaceae 186801|Clostridia E cysteine desulfurase family protein csd2 - - - - - - - - - - - Aminotran_5 k59_270574_1 760192.Halhy_3411 6.44e-56 181.0 COG0640@1|root,COG0640@2|Bacteria,4NS23@976|Bacteroidetes,1IT8B@117747|Sphingobacteriia 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - HTH_DeoR k59_76356_1 1165841.SULAR_04367 2.28e-12 65.9 COG4487@1|root,COG4487@2|Bacteria,1MWNT@1224|Proteobacteria,42NKA@68525|delta/epsilon subdivisions,2YMC2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2130 k59_76356_2 85962.C694_06885 1.17e-75 235.0 COG1432@1|root,COG1432@2|Bacteria,1R9SC@1224|Proteobacteria,42V0U@68525|delta/epsilon subdivisions,2YR6I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S NYN domain - - - - - - - - - - - - NYN k59_958149_1 869213.JCM21142_210 3.45e-30 127.0 COG1262@1|root,COG1262@2|Bacteria,4NGWF@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF1566) - - - - - - - - - - - - DUF1566 k59_665115_1 1249480.B649_02405 1.51e-07 51.6 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2YN0Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_665115_2 1249480.B649_02400 2.48e-112 330.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2YNV5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_665115_3 709032.Sulku_0480 4.9e-91 276.0 COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1NF4E@1224|Proteobacteria,42R4G@68525|delta/epsilon subdivisions,2YN6N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar motor switch protein fliY - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C k59_377972_2 1121396.KB893123_gene1076 9.23e-84 266.0 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,42PCY@68525|delta/epsilon subdivisions,2WJCR@28221|Deltaproteobacteria,2MN94@213118|Desulfobacterales 28221|Deltaproteobacteria NT Single cache domain 3 - - - ko:K03406,ko:K13487 ko02020,ko02025,ko02030,map02020,map02025,map02030 - - - ko00000,ko00001,ko02035 - - - Cache_3-Cache_2,HAMP,MCPsignal k59_442424_1 404380.Gbem_0052 2.15e-14 78.2 COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_9,Response_reg k59_934140_1 1168034.FH5T_14155 2.4e-30 114.0 COG0462@1|root,COG0462@2|Bacteria,4NEVF@976|Bacteroidetes,2FPH1@200643|Bacteroidia 976|Bacteroidetes F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_934140_2 1168034.FH5T_14150 2.03e-65 203.0 COG0218@1|root,COG0218@2|Bacteria,4NEA9@976|Bacteroidetes,2FM4M@200643|Bacteroidia 976|Bacteroidetes D Necessary for normal cell division and for the maintenance of normal septation engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_900909_1 933262.AXAM01000044_gene1408 2.9e-71 229.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2MKFC@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_867649_1 247633.GP2143_07959 3.62e-76 245.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1030982_1 1121937.AUHJ01000031_gene3081 7.82e-122 355.0 COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,1RS6V@1236|Gammaproteobacteria,464BY@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - 4.1.1.77 ko:K01617 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R02602,R05374 RC00751,RC02672 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_1030982_2 1123401.JHYQ01000023_gene1184 1.4e-05 46.2 COG0119@1|root,COG0119@2|Bacteria,1MVQG@1224|Proteobacteria,1RPPW@1236|Gammaproteobacteria,460HJ@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds - - 4.1.3.39,4.1.3.43 ko:K01666,ko:K18365 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750,R05298 RC00307,RC00371,RC00572 br01602,ko00000,ko00001,ko00002,ko01000 - - - DmpG_comm,HMGL-like k59_999574_1 765912.Thimo_1564 1.13e-55 196.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_410366_1 1565314.OA34_07985 2.57e-65 221.0 COG4774@1|root,COG4774@2|Bacteria,1QU2Y@1224|Proteobacteria,43CFU@68525|delta/epsilon subdivisions,2YTF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M PFAM TonB-dependent Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - TonB_dep_Rec k59_182914_1 926550.CLDAP_29120 6.91e-137 394.0 COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi 200795|Chloroflexi C PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_49171_1 909663.KI867150_gene2888 1.42e-80 259.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,2MQ9F@213462|Syntrophobacterales 28221|Deltaproteobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_736358_1 765912.Thimo_1977 4.2e-25 107.0 COG5380@1|root,COG5380@2|Bacteria,1N6UY@1224|Proteobacteria,1S03R@1236|Gammaproteobacteria,1WX19@135613|Chromatiales 135613|Chromatiales O lipid catabolic process - - - - - - - - - - - - - k59_799482_1 1123278.KB893579_gene869 4.37e-44 150.0 COG0796@1|root,COG0796@2|Bacteria,4NG1C@976|Bacteroidetes,47MMI@768503|Cytophagia 976|Bacteroidetes M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_799482_2 269798.CHU_1581 4.58e-86 272.0 COG0438@1|root,COG0438@2|Bacteria,4PKQN@976|Bacteroidetes,47K56@768503|Cytophagia 976|Bacteroidetes M PFAM glycogen synthase - - 2.4.1.11 ko:K00693 ko00500,ko01100,ko04151,ko04152,ko04910,ko04922,ko04931,map00500,map01100,map04151,map04152,map04910,map04922,map04931 - R00292 RC00005 ko00000,ko00001,ko01000,ko01003 - GT3 - Glycogen_syn k59_83608_1 375286.mma_2403 1.02e-30 124.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,472FR@75682|Oxalobacteraceae 28216|Betaproteobacteria M Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_247035_1 867903.ThesuDRAFT_00642 7.55e-136 423.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,3WCDF@538999|Clostridiales incertae sedis 186801|Clostridia J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_247035_2 1183438.GKIL_4364 1.45e-06 56.2 COG2339@1|root,COG2339@2|Bacteria,1GB65@1117|Cyanobacteria 1117|Cyanobacteria S Protease prsW family - - - - - - - - - - - - PrsW-protease k59_442435_1 1168034.FH5T_09180 1.15e-40 143.0 COG1082@1|root,COG1082@2|Bacteria,4NJ3Z@976|Bacteroidetes,2FX90@200643|Bacteroidia 976|Bacteroidetes G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_934143_1 1172190.M947_02840 7.86e-67 215.0 COG0795@1|root,COG0795@2|Bacteria,1PXEK@1224|Proteobacteria,42MVG@68525|delta/epsilon subdivisions,2YN6F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S permease - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_377989_1 2340.JV46_05260 8.55e-89 273.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1J515@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Flavocytochrome c sulphide dehydrogenase, flavin-binding fccB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_510216_1 326298.Suden_1929 2.96e-41 144.0 COG0790@1|root,COG0790@2|Bacteria,1NY7Z@1224|Proteobacteria,42T5I@68525|delta/epsilon subdivisions,2YPQ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0790 FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_410372_1 326298.Suden_1220 5.18e-95 300.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,42ZKZ@68525|delta/epsilon subdivisions 1224|Proteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_1031010_1 886377.Murru_1997 1.24e-144 424.0 COG2936@1|root,COG2936@2|Bacteria,4NHGT@976|Bacteroidetes,1HYGE@117743|Flavobacteriia 976|Bacteroidetes S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - 3.4.14.11 ko:K01281 - - - - ko00000,ko01000,ko01002 - - - PepX_C,Peptidase_S15 k59_49178_1 349163.Acry_0024 4.35e-20 88.6 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,2JVW8@204441|Rhodospirillales 204441|Rhodospirillales M Polysaccharide biosynthesis protein - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_49178_2 945550.VISI1226_21494 2.93e-76 238.0 COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,1RNVI@1236|Gammaproteobacteria,1XU77@135623|Vibrionales 135623|Vibrionales F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism - - 3.5.4.2 ko:K21053 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_49180_1 1095769.CAHF01000001_gene3559 2.57e-49 172.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,473Q4@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_182934_1 1121481.AUAS01000005_gene2109 1.29e-64 209.0 COG1735@1|root,COG1735@2|Bacteria,4NJYF@976|Bacteroidetes,47NZQ@768503|Cytophagia 976|Bacteroidetes S Phosphotriesterase family php - - ko:K07048 - - - - ko00000 - - - PTE k59_640054_1 314287.GB2207_09811 1.48e-16 73.6 COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,1S9KN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_640054_2 392500.Swoo_1672 1.94e-69 221.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,2QEPK@267890|Shewanellaceae 1236|Gammaproteobacteria L PFAM Integrase, catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_442444_1 323261.Noc_2658 3.23e-47 160.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1WY2J@135613|Chromatiales 135613|Chromatiales D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf k59_442444_2 395493.BegalDRAFT_2635 1.49e-18 84.3 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,45ZW6@72273|Thiotrichales 72273|Thiotrichales J ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_150302_1 95619.PM1_0216640 4.69e-129 388.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Single-stranded-DNA-specific exonuclease recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_966363_1 1168034.FH5T_08730 2.54e-223 622.0 COG0673@1|root,COG0673@2|Bacteria,4NF9M@976|Bacteroidetes,2FP2F@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,TAT_signal k59_966363_2 927658.AJUM01000034_gene436 2.24e-23 99.0 COG1262@1|root,COG3005@1|root,COG1262@2|Bacteria,COG3005@2|Bacteria,4NEUZ@976|Bacteroidetes,2G2PJ@200643|Bacteroidia,3XM0I@558415|Marinilabiliaceae 976|Bacteroidetes C Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - Cytochrom_NNT,FGE-sulfatase k59_215425_1 1165841.SULAR_00795 3.16e-53 177.0 COG0697@1|root,COG0697@2|Bacteria,1QA9R@1224|Proteobacteria,42RRA@68525|delta/epsilon subdivisions,2YRCY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_14222_1 990073.ATHU01000001_gene1785 4.41e-35 121.0 2A433@1|root,30SN2@2|Bacteria,1PBWY@1224|Proteobacteria,42VT4@68525|delta/epsilon subdivisions,2YQB2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_279224_1 1165841.SULAR_09829 6.83e-20 85.1 COG3770@1|root,COG3770@2|Bacteria,1PXYG@1224|Proteobacteria 1224|Proteobacteria M Penicillin-insensitive murein endopeptidase - - - ko:K07261 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M74 k59_868743_2 1168034.FH5T_21730 1.09e-35 134.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,4NFUJ@976|Bacteroidetes,2FM2T@200643|Bacteroidia 976|Bacteroidetes C Psort location Cytoplasmic, score maeB - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_14225_1 1268072.PSAB_04580 2.12e-07 57.4 COG1845@1|root,COG1845@2|Bacteria,1TQJ1@1239|Firmicutes,4HCWH@91061|Bacilli,26R4B@186822|Paenibacillaceae 91061|Bacilli C cytochrome o ubiquinol oxidase, subunit III qoxC GO:0003674,GO:0003824,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016679,GO:0016682,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.10.3.12 ko:K02828 ko00190,ko01100,map00190,map01100 M00416 R09492 RC00819 ko00000,ko00001,ko00002,ko01000 - - - COX3 k59_117711_1 1168034.FH5T_17600 1.69e-39 142.0 COG1660@1|root,COG3178@1|root,COG1660@2|Bacteria,COG3178@2|Bacteria,4NIT0@976|Bacteroidetes,2FMEM@200643|Bacteroidia 976|Bacteroidetes S Phosphotransferase enzyme family - - - - - - - - - - - - APH,ATP_bind_2 k59_1032012_1 1218084.BBJK01000149_gene7524 4.57e-05 46.2 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WBWX@28216|Betaproteobacteria,1K6U7@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_1032012_2 1217718.ALOU01000112_gene4316 2.96e-49 169.0 COG1075@1|root,COG1075@2|Bacteria,1NSK3@1224|Proteobacteria,2WG1G@28216|Betaproteobacteria,1KI8H@119060|Burkholderiaceae 28216|Betaproteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_641045_1 1121405.dsmv_3396 5.22e-13 69.7 COG4656@1|root,COG4656@2|Bacteria,1QMZ4@1224|Proteobacteria,42NJ5@68525|delta/epsilon subdivisions,2WKCG@28221|Deltaproteobacteria,2MIQX@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,RnfC_N k59_641045_2 933262.AXAM01000029_gene2745 1.01e-43 151.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,2MHVT@213118|Desulfobacterales 28221|Deltaproteobacteria C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_543103_1 1237149.C900_00233 2.49e-122 379.0 COG0358@1|root,COG0630@1|root,COG0358@2|Bacteria,COG0630@2|Bacteria,4NI2W@976|Bacteroidetes,47NGY@768503|Cytophagia 976|Bacteroidetes LNU type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_511156_1 749222.Nitsa_0613 1.4e-09 56.2 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42R6H@68525|delta/epsilon subdivisions,2YP0H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_511156_2 749222.Nitsa_0614 8.44e-80 247.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2YME5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_117721_1 1454004.AW11_02387 1.38e-75 239.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2VHI3@28216|Betaproteobacteria 28216|Betaproteobacteria I Outer membrane protein transport protein, Ompp1 FadL TodX - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_575456_1 1249480.B649_09450 1.64e-42 150.0 COG0446@1|root,COG0446@2|Bacteria,1PWV7@1224|Proteobacteria,42QCM@68525|delta/epsilon subdivisions,2YND4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG1252 NADH dehydrogenase FAD-containing subunit - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_575456_2 929558.SMGD1_2083 1.63e-09 58.5 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2YR60@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Domain of unknown function (DUF3458_C) ARM repeats - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_967474_2 1121351.AUAP01000001_gene718 1.71e-58 192.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,2KQDB@206351|Neisseriales 206351|Neisseriales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_868768_1 572544.Ilyop_0476 3.47e-39 140.0 COG1929@1|root,COG1929@2|Bacteria,379HN@32066|Fusobacteria 32066|Fusobacteria G Belongs to the glycerate kinase type-1 family - - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase k59_608430_1 519989.ECTPHS_08968 6.74e-42 157.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales 135613|Chromatiales C pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_84619_1 387093.SUN_1320 8.7e-22 92.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2YMHR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_84619_2 1165841.SULAR_01310 4.6e-37 135.0 29CAW@1|root,2ZZ9C@2|Bacteria,1Q5FH@1224|Proteobacteria,42Q2S@68525|delta/epsilon subdivisions,2YQ1W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_967478_2 385682.AFSL01000105_gene85 4.22e-35 130.0 COG1451@1|root,COG1451@2|Bacteria,4NNY6@976|Bacteroidetes,2FPFA@200643|Bacteroidia,3XJN6@558415|Marinilabiliaceae 976|Bacteroidetes S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_84636_1 556261.HMPREF0240_01472 2.22e-217 612.0 COG0407@1|root,COG0407@2|Bacteria,1UYXW@1239|Firmicutes,25DH8@186801|Clostridia,36H1T@31979|Clostridiaceae 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - Thioredoxin_3,URO-D k59_14249_1 1117108.PAALTS15_00930 2.94e-26 107.0 COG1653@1|root,COG1653@2|Bacteria,1TR3D@1239|Firmicutes,4HCHA@91061|Bacilli,26TVS@186822|Paenibacillaceae 91061|Bacilli G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 k59_347659_3 228410.NE1602 1.62e-12 67.8 COG2165@1|root,COG2165@2|Bacteria,1N1QJ@1224|Proteobacteria,2VTYJ@28216|Betaproteobacteria,37385@32003|Nitrosomonadales 28216|Betaproteobacteria U PFAM type II secretion system protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_347659_4 443144.GM21_2997 7.92e-27 104.0 COG2165@1|root,COG2165@2|Bacteria,1N1QJ@1224|Proteobacteria 1224|Proteobacteria U type II secretion system protein G oxpG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_347659_5 1095769.CAHF01000022_gene429 1.01e-27 107.0 COG2165@1|root,COG2165@2|Bacteria,1RGZZ@1224|Proteobacteria,2VSZ6@28216|Betaproteobacteria,4773W@75682|Oxalobacteraceae 28216|Betaproteobacteria U prepilin-type N-terminal cleavage methylation - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_347659_6 690850.Desaf_1235 1.35e-40 156.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MAHG@213115|Desulfovibrionales 28221|Deltaproteobacteria U PFAM type II secretion system gspF - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_347659_7 545697.HMPREF0216_02287 1.48e-138 402.0 COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,36GDV@31979|Clostridiaceae 186801|Clostridia O PFAM AIR synthase related protein hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_50242_1 411470.RUMGNA_01001 3.37e-42 149.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,24BWQ@186801|Clostridia 186801|Clostridia G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - - - - - - - - - - DctP k59_50242_2 1158606.I579_00241 1.05e-24 100.0 COG3090@1|root,COG3090@2|Bacteria,1V3SM@1239|Firmicutes,4HK4Y@91061|Bacilli,4B2P1@81852|Enterococcaceae 91061|Bacilli G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_50242_3 515620.EUBELI_20227 1.91e-186 533.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,25VRS@186806|Eubacteriaceae 186801|Clostridia G Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DctM k59_151343_2 1353537.TP2_15400 2.14e-63 206.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2XNAT@285107|Thioclava 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_575488_1 1209072.ALBT01000023_gene4042 1.48e-64 208.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1FGIX@10|Cellvibrio 1236|Gammaproteobacteria J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_575488_2 765914.ThisiDRAFT_0970 8.39e-14 72.4 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales 135613|Chromatiales GM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_800427_1 582899.Hden_0690 3.05e-18 84.0 COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_800427_2 1417296.U879_08070 2.22e-90 270.0 COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,2U2FE@28211|Alphaproteobacteria 28211|Alphaproteobacteria C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4_8 k59_1000462_1 945713.IALB_1601 8.71e-118 358.0 COG0659@1|root,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - iSbBS512_1146.SbBS512_E1370 STAS,Sulfate_transp k59_443522_1 2340.JV46_12700 2.9e-83 258.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1J4PD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_476602_1 944547.ABLL_2601 5.9e-116 340.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N1I@68525|delta/epsilon subdivisions,2YMA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome ccpA - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_543145_1 1197906.CAJQ02000040_gene1586 3.48e-66 210.0 COG5530@1|root,COG5530@2|Bacteria,1R6P3@1224|Proteobacteria,2TUPW@28211|Alphaproteobacteria,3JX7R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Predicted integral membrane protein (DUF2270) - - - - - - - - - - - - DUF2270 k59_836513_1 95619.PM1_0226330 2.08e-104 322.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent protease - - - - - - - - - - - - Peptidase_M48 k59_967504_1 519989.ECTPHS_00909 6.23e-160 461.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1WWCI@135613|Chromatiales 135613|Chromatiales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_476608_1 1168034.FH5T_08655 1.59e-65 206.0 COG0434@1|root,COG0434@2|Bacteria,4P0R6@976|Bacteroidetes 976|Bacteroidetes S BtpA family - - - ko:K06971 - - - - ko00000 - - - BtpA k59_641111_1 936136.ARRT01000006_gene5873 2.53e-46 169.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,4B7MU@82115|Rhizobiaceae 28211|Alphaproteobacteria M penicillin-binding protein pbpC - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_481642_1 2340.JV46_19400 1.15e-85 270.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1J4H2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_548868_2 1033743.CAES01000064_gene4137 5.39e-27 113.0 COG0642@1|root,COG0745@1|root,COG2972@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG2972@2|Bacteria,1TRIG@1239|Firmicutes,4HD8X@91061|Bacilli,26QIJ@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase - - - - - - - - - - - - 7TMR-DISM_7TM,HATPase_c,HisKA,His_kinase,Response_reg k59_941411_1 485917.Phep_2438 8.99e-15 75.9 COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,4NNX5@976|Bacteroidetes,1IX2F@117747|Sphingobacteriia 976|Bacteroidetes S Uncharacterised conserved protein (DUF2156) - - 2.3.2.3 ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504 2.A.1.3.37 - - DUF2156,LPG_synthase_TM k59_318573_1 1415779.JOMH01000001_gene183 5.73e-24 102.0 28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_318573_2 1279017.AQYJ01000022_gene2616 5.06e-16 77.4 2EDVS@1|root,337QX@2|Bacteria,1NEZW@1224|Proteobacteria,1SCKV@1236|Gammaproteobacteria,46C7E@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_222508_1 96561.Dole_1163 8.86e-43 149.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,2MJHY@213118|Desulfobacterales 28221|Deltaproteobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_450372_2 498211.CJA_3040 3.69e-10 61.2 COG0497@1|root,COG0497@2|Bacteria,1R0MC@1224|Proteobacteria,1SMYQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA recombination - - - - - - - - - - - - - k59_875009_2 1537917.JU82_00565 6.4e-25 94.7 2AJ3H@1|root,319MX@2|Bacteria,1Q39A@1224|Proteobacteria,42WZA@68525|delta/epsilon subdivisions,2YQQE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - DUF2892 k59_875009_3 1537917.JU82_00560 3.41e-84 253.0 COG0421@1|root,COG0421@2|Bacteria,1PD55@1224|Proteobacteria,42UAB@68525|delta/epsilon subdivisions,2YPTY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_875009_4 709032.Sulku_0101 7.74e-27 103.0 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,42RI5@68525|delta/epsilon subdivisions,2YP6Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0831 CoaE k59_777322_1 1120951.AUBG01000002_gene1322 1.07e-94 300.0 COG0188@1|root,COG0188@2|Bacteria,4NERI@976|Bacteroidetes,1HWVT@117743|Flavobacteriia 976|Bacteroidetes L Belongs to the type II topoisomerase GyrA ParC subunit family parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_topoisoIV k59_777324_2 112098.XP_008607639.1 1.68e-26 111.0 COG0484@1|root,KOG0715@2759|Eukaryota 2759|Eukaryota O heat shock protein binding - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_743317_1 876044.IMCC3088_1765 7.34e-46 155.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_743317_2 1122194.AUHU01000015_gene2979 3.52e-16 78.2 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,464TP@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_285545_1 105559.Nwat_2038 8.89e-157 456.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1006560_1 742733.HMPREF9469_05004 1.04e-06 53.1 COG1879@1|root,COG1879@2|Bacteria,1VTWD@1239|Firmicutes,24YC2@186801|Clostridia 186801|Clostridia K COG COG1879 ABC-type sugar transport system, periplasmic component - - - - - - - - - - - - LacI,Peripla_BP_4 k59_385775_1 713586.KB900536_gene1715 3.41e-39 134.0 COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1S5GE@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the bacterial histone-like protein family VL23_14575 - - - - - - - - - - - Bac_DNA_binding k59_158187_1 572544.Ilyop_1349 5.3e-87 278.0 COG1480@1|root,COG1480@2|Bacteria,378ZH@32066|Fusobacteria 32066|Fusobacteria S 7TM receptor with intracellular HD hydrolase - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_875026_1 1537917.JU82_09715 1.1e-96 310.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42MWW@68525|delta/epsilon subdivisions,2YMMH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_842480_1 1049564.TevJSym_ad01110 8.56e-76 251.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1J8WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyltransferase,Aminotran_1_2,NAD_binding_4,PP-binding,Thioesterase k59_647500_1 335543.Sfum_0014 4.83e-70 236.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1Q199@1224|Proteobacteria,42NDM@68525|delta/epsilon subdivisions,2WIQH@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin, iron-sulfur binding - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_581979_1 765911.Thivi_1869 1.42e-190 540.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_581979_2 631362.Thi970DRAFT_01080 2.95e-146 421.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales 135613|Chromatiales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_581979_3 697282.Mettu_3280 7.78e-83 256.0 28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria,1RP8T@1236|Gammaproteobacteria,1XG6M@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_581979_4 589865.DaAHT2_2095 2.54e-146 421.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2MIIT@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_973371_3 862908.BMS_0467 2.94e-123 357.0 COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,42ZSX@68525|delta/epsilon subdivisions,2WV17@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_973371_4 292.DM42_3839 6.45e-05 48.1 COG1846@1|root,COG1846@2|Bacteria,1MZY5@1224|Proteobacteria,2VW6K@28216|Betaproteobacteria,1KFN0@119060|Burkholderiaceae 28216|Betaproteobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - MarR,MarR_2 k59_973371_5 1121396.KB892969_gene1031 5.43e-35 120.0 COG4925@1|root,COG4925@2|Bacteria,1QT72@1224|Proteobacteria,43F1Z@68525|delta/epsilon subdivisions,2X321@28221|Deltaproteobacteria,2MP8F@213118|Desulfobacterales 28221|Deltaproteobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - - - - - - - - - - - - k59_482222_1 1168034.FH5T_17760 1.39e-97 302.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,4NF2R@976|Bacteroidetes,2FQYA@200643|Bacteroidia 976|Bacteroidetes HJ Belongs to the D-alanine--D-alanine ligase family - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_941463_1 1121937.AUHJ01000009_gene1482 1.03e-89 274.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,1RNTW@1236|Gammaproteobacteria,465GE@72275|Alteromonadaceae 1236|Gammaproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008776,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016741,GO:0016742,GO:0016772,GO:0016774,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_1135 ATP-grasp,Epimerase k59_743342_1 1528106.JRJE01000032_gene2602 1.22e-56 192.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria,2JRMZ@204441|Rhodospirillales 204441|Rhodospirillales S RmuC family - - - ko:K09760 - - - - ko00000 - - - RmuC k59_777357_1 991905.SL003B_4076 1.32e-105 311.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TVMM@28211|Alphaproteobacteria,4BS3F@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_124198_1 1168034.FH5T_05875 1.22e-188 536.0 COG1508@1|root,COG1508@2|Bacteria,4NE5B@976|Bacteroidetes,2FM52@200643|Bacteroidia 976|Bacteroidetes K RNA polymerase sigma54 factor rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_875046_1 34506.g2405 3.31e-98 297.0 COG0526@1|root,KOG0910@2759|Eukaryota 2759|Eukaryota O glycerol ether metabolic process - - - - - - - - - - - - Thioredoxin k59_158213_1 1458275.AZ34_16075 1.82e-36 137.0 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,4AAGS@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_158213_2 62977.ACIAD0854 1.35e-18 82.0 COG1225@1|root,COG1225@2|Bacteria,1RH4P@1224|Proteobacteria,1SBKN@1236|Gammaproteobacteria,3NM03@468|Moraxellaceae 1236|Gammaproteobacteria O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_482230_1 998674.ATTE01000001_gene4168 2.2e-107 328.0 COG1196@1|root,COG1196@2|Bacteria,1MVMQ@1224|Proteobacteria,1S2MH@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_417212_1 1238182.C882_1968 1.43e-117 357.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,2JQ9A@204441|Rhodospirillales 204441|Rhodospirillales F formate-tetrahydrofolate ligase activity fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_91512_1 1202962.KB907164_gene3925 2.61e-49 176.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_285590_1 1123504.JQKD01000041_gene2856 2.46e-29 111.0 COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,2VQ4B@28216|Betaproteobacteria,4ADII@80864|Comamonadaceae 28216|Betaproteobacteria O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_285590_2 1123255.JHYS01000014_gene557 1.37e-23 100.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,4AARG@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_56359_1 1150600.ADIARSV_1542 1.16e-58 198.0 COG4584@1|root,COG4584@2|Bacteria,4NEY6@976|Bacteroidetes,1IPYU@117747|Sphingobacteriia 976|Bacteroidetes L PFAM Integrase, catalytic core - - - - - - - - - - - - rve k59_875060_1 1219035.NT2_18_00040 3.69e-06 54.3 COG4625@1|root,COG4625@2|Bacteria,1N4H5@1224|Proteobacteria,2TT5A@28211|Alphaproteobacteria 28211|Alphaproteobacteria S outer membrane autotransporter barrel - - - - - - - - - - - - Autotransporter k59_1038725_1 765912.Thimo_3399 2.09e-32 119.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria,1WYE4@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_450451_1 1165841.SULAR_08452 1.57e-127 379.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_190232_1 471854.Dfer_2123 3.25e-25 102.0 COG5618@1|root,COG5618@2|Bacteria,4NRFA@976|Bacteroidetes,47UUR@768503|Cytophagia 976|Bacteroidetes S Predicted periplasmic lipoprotein (DUF2291) - - - - - - - - - - - - DUF2291 k59_190232_2 1268068.PG5_55780 1.2e-09 59.3 COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the carbamate kinase family arcC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - iE2348C_1286.E2348C_0454,iECED1_1282.ECED1_0540,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iJN746.PP_0999 AA_kinase k59_417230_1 631362.Thi970DRAFT_03277 1.13e-79 247.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WWB0@135613|Chromatiales 135613|Chromatiales S PFAM von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_450458_1 1120965.AUBV01000005_gene1711 1.36e-50 173.0 COG1609@1|root,COG1609@2|Bacteria,4NFB7@976|Bacteroidetes,47JAA@768503|Cytophagia 976|Bacteroidetes K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR,Peripla_BP_3 k59_285616_2 913325.N799_10530 2.21e-25 97.4 COG0271@1|root,COG0271@2|Bacteria,1QCDM@1224|Proteobacteria,1RTFD@1236|Gammaproteobacteria,1X7ES@135614|Xanthomonadales 135614|Xanthomonadales T Belongs to the BolA IbaG family - - - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_285616_3 748280.NH8B_1713 5.21e-08 50.8 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2VUM7@28216|Betaproteobacteria,2KRJ4@206351|Neisseriales 206351|Neisseriales S YCII-related domain - - - ko:K09780 - - - - ko00000 - - - YCII k59_712180_2 1123296.JQKE01000050_gene1120 2.66e-31 117.0 COG4278@1|root,COG4278@2|Bacteria,1N6VA@1224|Proteobacteria,2VWWK@28216|Betaproteobacteria 28216|Betaproteobacteria H phenylacetate-CoA ligase activity - - - - - - - - - - - - - k59_875081_1 497964.CfE428DRAFT_5992 1.78e-74 248.0 COG3829@1|root,COG3829@2|Bacteria 2|Bacteria T transcription factor binding - - - ko:K15836 - - - - ko00000,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_20731_1 1304872.JAGC01000009_gene1532 1.16e-69 233.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MAAB@213115|Desulfovibrionales 28221|Deltaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_614774_1 398720.MED217_08775 4.46e-69 234.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1IJ92@117743|Flavobacteriia 976|Bacteroidetes H Outer membrane receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_842530_2 1442598.JABW01000003_gene117 3.38e-15 77.8 COG3704@1|root,COG3704@2|Bacteria,1P5RF@1224|Proteobacteria,42SHH@68525|delta/epsilon subdivisions,2YPJC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U TrbL/VirB6 plasmid conjugal transfer protein - - - ko:K03201 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - TrbL k59_222600_1 1237149.C900_02818 9.15e-30 124.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,47K68@768503|Cytophagia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1006619_1 661478.OP10G_0704 2.05e-32 128.0 COG1007@1|root,COG1007@2|Bacteria 2|Bacteria C ATP synthesis coupled electron transport nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1006620_1 349124.Hhal_1184 1.77e-22 95.5 COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1WYR7@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0149 family - - - ko:K09895 - - - - ko00000 - - - UPF0149 k59_285656_1 1249480.B649_04705 2.08e-52 184.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2YMRQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_190267_1 572544.Ilyop_1457 7.18e-58 184.0 COG1059@1|root,COG1059@2|Bacteria,37905@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 8.96 ogg - 4.2.99.18 ko:K03653 - - - - ko00000,ko01000 - - - - k59_190267_2 926549.KI421517_gene941 2.36e-41 148.0 COG0038@1|root,COG0038@2|Bacteria,4NEIA@976|Bacteroidetes,47JNF@768503|Cytophagia 976|Bacteroidetes P Chloride channel - - - - - - - - - - - - Voltage_CLC k59_582070_1 1123376.AUIU01000016_gene250 4.93e-10 61.2 COG0438@1|root,COG0438@2|Bacteria,3J19R@40117|Nitrospirae 40117|Nitrospirae M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_582070_2 1437882.AZRU01000013_gene6978 1.23e-41 150.0 COG0438@1|root,COG0500@1|root,COG0438@2|Bacteria,COG2226@2|Bacteria,1R7N8@1224|Proteobacteria,1SJUD@1236|Gammaproteobacteria,1YFFR@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Glycosyltransferase - - - - - - - - - - - - Glyco_trans_1_4 k59_806681_2 563040.Saut_2105 5.47e-60 188.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,42SIR@68525|delta/epsilon subdivisions,2YP9V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_353774_1 96561.Dole_0194 1.05e-70 237.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,43BQI@68525|delta/epsilon subdivisions 1224|Proteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4,1.8.5.3 ko:K00370,ko:K07306,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500,R09501 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.3,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_386594_1 1461580.CCAS010000022_gene2386 6.61e-164 469.0 COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,4HADP@91061|Bacilli,1ZAP3@1386|Bacillus 91061|Bacilli M Belongs to the UDP-glucose GDP-mannose dehydrogenase family tuaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_908562_1 326298.Suden_1143 4.82e-98 297.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2YMUR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_974016_1 572544.Ilyop_1782 7.95e-123 357.0 COG0202@1|root,COG0202@2|Bacteria,3791W@32066|Fusobacteria 32066|Fusobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_57208_1 709032.Sulku_0520 5.91e-101 311.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,42M6B@68525|delta/epsilon subdivisions,2YN3C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_550221_1 1122604.JONR01000022_gene627 5.25e-156 454.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,1X4BB@135614|Xanthomonadales 135614|Xanthomonadales EGP major facilitator superfamily emrB - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_32221_1 1168034.FH5T_02090 5.88e-99 315.0 COG4772@1|root,COG4772@2|Bacteria,4PM03@976|Bacteroidetes,2G09Q@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_32259_1 522306.CAP2UW1_1254 2.57e-48 160.0 COG3133@1|root,COG3133@2|Bacteria 2|Bacteria M Outer membrane lipoprotein pcp - - ko:K06077 - - - - ko00000 - - - Rick_17kDa_Anti k59_32292_1 342610.Patl_2231 2.99e-42 158.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_32309_1 335283.Neut_1201 7.75e-70 224.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2VI6V@28216|Betaproteobacteria,3720R@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_32432_1 1168034.FH5T_01780 8.22e-138 407.0 COG0561@1|root,COG0561@2|Bacteria,4PKHD@976|Bacteroidetes,2G0K6@200643|Bacteroidia 976|Bacteroidetes S Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_32449_1 1304284.L21TH_0829 3.13e-104 321.0 COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,1TP5X@1239|Firmicutes,247WT@186801|Clostridia,36DI9@31979|Clostridiaceae 186801|Clostridia G Pts system - - 2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02809,ko:K02810 ko00500,ko02060,map00500,map02060 M00269,M00271 R00811 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6,4.A.1.2.9 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_32514_1 572544.Ilyop_0610 5.09e-33 124.0 COG1044@1|root,COG1044@2|Bacteria,378VP@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_32514_2 266779.Meso_4517 1.55e-10 63.5 COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2U06F@28211|Alphaproteobacteria,43HZP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S PFAM Oxidoreductase family, NAD-binding Rossmann fold socC - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_32551_2 525898.Sdel_1721 6.28e-130 377.0 28K88@1|root,2Z9W2@2|Bacteria,1R5CF@1224|Proteobacteria 1224|Proteobacteria L NgoPII restriction endonuclease - - - - - - - - - - - - RE_NgoPII k59_32551_3 326298.Suden_0945 9.59e-213 598.0 COG1746@1|root,COG1746@2|Bacteria,1NVSS@1224|Proteobacteria 1224|Proteobacteria J tRNA cytidylyltransferase activity - - - - - - - - - - - - NTP_transf_2 k59_32551_4 326298.Suden_0946 4.31e-81 245.0 29T71@1|root,30EDT@2|Bacteria,1RFDY@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_32551_5 525898.Sdel_1722 2.46e-197 552.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,42RBB@68525|delta/epsilon subdivisions,2YR8T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_32588_1 1150469.RSPPHO_00278 1.42e-65 209.0 COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2U613@28211|Alphaproteobacteria,2JSGA@204441|Rhodospirillales 204441|Rhodospirillales Q methyltransferase - - - - - - - - - - - - Methyltransf_25 k59_32598_2 759362.KVU_1407 3.14e-79 236.0 COG0309@1|root,COG0309@2|Bacteria,1RDJ4@1224|Proteobacteria,2U7HE@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG3293 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_32598_3 1437448.AZRT01000126_gene323 4.66e-41 137.0 COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2U7E3@28211|Alphaproteobacteria,1J46G@118882|Brucellaceae 28211|Alphaproteobacteria L Putative transposase of IS4/5 family (DUF4096) - - - ko:K07492 - - - - ko00000 - - - DUF4096 k59_32617_1 1158345.JNLL01000001_gene10 3.04e-135 400.0 arCOG03638@1|root,2Z8W3@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_32646_1 555778.Hneap_1500 6.18e-14 68.9 COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1WY0V@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_32646_2 1349822.NSB1T_04370 6.08e-15 75.1 COG0438@1|root,COG0438@2|Bacteria,4NEJ6@976|Bacteroidetes,2FMCY@200643|Bacteroidia,22Y9E@171551|Porphyromonadaceae 976|Bacteroidetes M Domain of unknown function (DUF1972) - - - - - - - - - - - - DUF1972,Glycos_transf_1 k59_555733_1 1094980.Mpsy_3073 4.02e-42 151.0 arCOG02376@1|root,arCOG02376@2157|Archaea,2Y7ZM@28890|Euryarchaeota 2157|Archaea T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_719181_1 1121875.KB907547_gene3144 3.04e-79 245.0 COG1005@1|root,COG1005@2|Bacteria,4NGK7@976|Bacteroidetes,1HY4Q@117743|Flavobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_523045_1 243233.MCA2160 2.77e-31 126.0 COG3291@1|root,COG3291@2|Bacteria,1R5MQ@1224|Proteobacteria 2|Bacteria C Cytochrome c5530 family protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Lipase_GDSL_2,PKD,TSP_3,VWA k59_686496_1 1260251.SPISAL_02645 6.69e-51 178.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1WWXY@135613|Chromatiales 135613|Chromatiales S Permease YjgP YjgQ - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_392286_1 1366050.N234_26610 4.42e-54 191.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,1K38N@119060|Burkholderiaceae 28216|Betaproteobacteria I Phospholipase D Transphosphatidylase - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_163458_2 4572.TRIUR3_00075-P1 1.03e-190 537.0 28ISP@1|root,2QR3X@2759|Eukaryota,37T53@33090|Viridiplantae,3G7SE@35493|Streptophyta,3KP6W@4447|Liliopsida,3IG0F@38820|Poales 35493|Streptophyta C One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light- driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation psbC - - ko:K02705 ko00195,ko01100,map00195,map01100 M00161 - - ko00000,ko00001,ko00002,ko00194 - - - PSII k59_784570_2 795666.MW7_2733 2.41e-41 147.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,1K3Q4@119060|Burkholderiaceae 28216|Betaproteobacteria NU twitching motility protein pilT - - ko:K02669,ko:K12203 - - - - ko00000,ko02035,ko02044 3.A.15.2,3.A.7.10.1,3.A.7.9.1 - - T2SSE k59_98085_1 1380391.JIAS01000012_gene4100 8.51e-58 192.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,2JQNE@204441|Rhodospirillales 204441|Rhodospirillales C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_849946_1 1415630.U771_09290 3.32e-44 162.0 COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase,PDH k59_621128_1 1168034.FH5T_14630 8.46e-255 707.0 COG1070@1|root,COG1070@2|Bacteria,4NFBZ@976|Bacteroidetes,2FPIS@200643|Bacteroidia 976|Bacteroidetes G Carbohydrate kinase, FGGY family protein xylB_2 - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_32724_1 398767.Glov_2578 1.33e-109 320.0 COG2820@1|root,COG2820@2|Bacteria,1QW1B@1224|Proteobacteria,42R3X@68525|delta/epsilon subdivisions,2WP50@28221|Deltaproteobacteria 28221|Deltaproteobacteria F PFAM purine or other phosphorylase family 1 - - - - - - - - - - - - PNP_UDP_1 k59_784583_1 3067.XP_002953537.1 1.2e-46 166.0 COG0626@1|root,KOG0053@2759|Eukaryota,37K09@33090|Viridiplantae,34GXJ@3041|Chlorophyta 3041|Chlorophyta E Cys/Met metabolism PLP-dependent enzyme CGS1 - 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_98102_1 565045.NOR51B_2751 1.08e-46 164.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_948033_1 287.DR97_3381 6.43e-35 137.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YEZ2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Signal transducing histidine kinase, homodimeric domain chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_392310_1 749222.Nitsa_0354 1.1e-83 275.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2YMA1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_163479_1 929558.SMGD1_2514 7.88e-103 310.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2YMMP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the peptidase M16 family pqqL - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_915344_1 1191523.MROS_0858 3.85e-78 249.0 COG0508@1|root,COG0508@2|Bacteria 2|Bacteria C S-acyltransferase activity aceF GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_0111,iSSON_1240.SSON_0123,iYL1228.KPN_00119 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_392312_1 326298.Suden_0499 7.42e-27 105.0 COG3301@1|root,COG3301@2|Bacteria,1QSRQ@1224|Proteobacteria,42PAY@68525|delta/epsilon subdivisions,2YN5Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_392312_2 929558.SMGD1_0715 2e-152 428.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M6H@68525|delta/epsilon subdivisions,2YNC6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S ferredoxin - - - - - - - - - - - - Fer4_11,Fer4_4 k59_588462_1 660470.Theba_0154 4.92e-13 69.7 COG0191@1|root,COG0191@2|Bacteria,2GDV6@200918|Thermotogae 200918|Thermotogae G Fructose-bisphosphate aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_588462_2 1444310.JANV01000095_gene3177 4.86e-17 79.7 COG0673@1|root,COG0673@2|Bacteria,1TQJX@1239|Firmicutes,4HAJ8@91061|Bacilli,1ZDU4@1386|Bacillus 91061|Bacilli S Oxidoreductase family, C-terminal alpha/beta domain iolG2 - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_196176_1 243233.MCA0338 1.22e-48 176.0 COG3291@1|root,COG3291@2|Bacteria,1R5MQ@1224|Proteobacteria,1TI1G@1236|Gammaproteobacteria,1XGA7@135618|Methylococcales 135618|Methylococcales C Cytochrome c5530 family protein - - - - - - - - - - - - - k59_425012_1 387093.SUN_1577 4.32e-87 265.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2YMSA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iIT341.HP0961 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_849976_1 96561.Dole_2788 4.13e-73 232.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2MIUK@213118|Desulfobacterales 28221|Deltaproteobacteria D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_523080_1 1319815.HMPREF0202_00248 3.27e-84 254.0 COG4656@1|root,COG4656@2|Bacteria,378Z7@32066|Fusobacteria 32066|Fusobacteria C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2,Fer2_4,Fer4_7 k59_359635_1 466088.CL42_07915 2.76e-18 93.2 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,3NM8W@468|Moraxellaceae 1236|Gammaproteobacteria S AI-2E family transporter perM - - - - - - - - - - - AI-2E_transport k59_686536_1 765910.MARPU_00820 1.36e-115 351.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_588477_2 765912.Thimo_3281 3.49e-63 195.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1WYD9@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_980743_1 1235457.C404_29345 5.36e-20 94.7 COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2WGN9@28216|Betaproteobacteria,1K1R2@119060|Burkholderiaceae 28216|Betaproteobacteria S transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_849986_1 999541.bgla_1g22890 9.79e-39 140.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,1JZX7@119060|Burkholderiaceae 28216|Betaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_621157_1 1121396.KB892990_gene4470 6.2e-104 307.0 COG0697@1|root,COG0697@2|Bacteria,1Q9JX@1224|Proteobacteria,434FQ@68525|delta/epsilon subdivisions,2WYT5@28221|Deltaproteobacteria,2MN71@213118|Desulfobacterales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_294251_1 1165841.SULAR_06488 8.31e-69 218.0 28IIB@1|root,2Z8JE@2|Bacteria,1QIR3@1224|Proteobacteria,430WH@68525|delta/epsilon subdivisions 1224|Proteobacteria S Glycosyltransferase family 10 (fucosyltransferase) C-term - - - - - - - - - - - - Glyco_transf_10 k59_588482_1 1121405.dsmv_0608 1.04e-58 197.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_294252_1 1537917.JU82_07115 1.25e-77 255.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,43BQI@68525|delta/epsilon subdivisions,2YRHF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K17050 - - - - ko00000,ko02000 5.A.3.8 - - Molybdopterin,Molydop_binding k59_784596_1 713586.KB900536_gene841 6.88e-29 111.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1RPCQ@1236|Gammaproteobacteria,1X2AC@135613|Chromatiales 135613|Chromatiales C N-terminal domain of oxidoreductase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_784596_2 338969.Rfer_1050 2.41e-45 154.0 COG0702@1|root,COG0702@2|Bacteria,1N1C0@1224|Proteobacteria,2VT7I@28216|Betaproteobacteria 28216|Betaproteobacteria GM Complex I intermediate-associated protein 30 - - - - - - - - - - - - CIA30 k59_784596_3 864073.HFRIS_014080 8.52e-66 212.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2VIJB@28216|Betaproteobacteria,473VU@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily - - 1.1.1.1,1.1.1.284 ko:K00001,ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_849991_1 1038862.KB893806_gene2742 3.76e-11 68.6 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TUA9@28211|Alphaproteobacteria,3JRPT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Carboxylesterase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase,PBP k59_719247_1 1128398.Curi_c21700 1.71e-61 213.0 COG0189@1|root,COG2918@1|root,COG0189@2|Bacteria,COG2918@2|Bacteria,1TPGX@1239|Firmicutes,25ER3@186801|Clostridia 186801|Clostridia H Belongs to the glutamate--cysteine ligase type 1 family gshF - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase,RimK k59_294256_1 572544.Ilyop_0555 1.51e-100 305.0 COG4865@1|root,COG4865@2|Bacteria,3798R@32066|Fusobacteria 32066|Fusobacteria E Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate) glmE - 5.4.99.1 ko:K19268 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R00262 RC01221 ko00000,ko00001,ko00002,ko01000 - - - Met_asp_mut_E k59_980755_1 1232437.KL662006_gene4420 4.01e-52 186.0 COG0769@1|root,COG0770@1|root,COG0769@2|Bacteria,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,43BV1@68525|delta/epsilon subdivisions,2X760@28221|Deltaproteobacteria,2MPKR@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.10,6.3.2.13 ko:K15792 ko00300,ko00550,map00300,map00550 - R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_980755_2 1122947.FR7_3215 3.81e-42 157.0 COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,4H1WR@909932|Negativicutes 909932|Negativicutes M PFAM penicillin-binding protein transpeptidase, Penicillin-binding protein dimerization domain-containing protein, PASTA domain containing protein - - - ko:K08384 ko00550,map00550 - - - ko00000,ko00001,ko01011 - - - PASTA,PBP_dimer,Transpeptidase k59_228898_1 1168034.FH5T_03475 8.68e-136 387.0 COG0564@1|root,COG0564@2|Bacteria,4NFS8@976|Bacteroidetes,2FN9G@200643|Bacteroidia 976|Bacteroidetes J Pseudouridine synthase rluC - 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 - - - - ko00000,ko01000,ko03009,ko03016 - - - PseudoU_synth_2 k59_719252_1 247634.GPB2148_990 3.39e-96 298.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_65427_1 326298.Suden_1272 5.44e-68 209.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2YPGX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the Fur family fur GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_65427_2 944547.ABLL_0796 7.08e-233 650.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2YMR5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_130819_1 1125863.JAFN01000001_gene1256 7.18e-37 136.0 COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,43BD6@68525|delta/epsilon subdivisions,2X6S2@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_196210_1 463191.SSEG_00450 4.12e-56 175.0 2D0VD@1|root,32T9B@2|Bacteria 2|Bacteria S COG NOG15344 non supervised orthologous group - - - - - - - - - - - - - k59_882718_1 1121904.ARBP01000005_gene4786 9.01e-87 273.0 COG2986@1|root,COG2986@2|Bacteria,4NE0D@976|Bacteroidetes,47MP5@768503|Cytophagia 976|Bacteroidetes E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_817314_1 768671.ThimaDRAFT_2038 1.24e-28 114.0 COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1S576@1236|Gammaproteobacteria,1WYCB@135613|Chromatiales 135613|Chromatiales S ABC-type transport auxiliary lipoprotein component - - - ko:K09857 - - - - ko00000 - - - ABC_trans_aux k59_980763_1 483219.LILAB_27605 1.78e-05 50.4 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2X734@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_196211_1 749222.Nitsa_2049 3.06e-76 247.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2YMUE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_294273_1 1385517.N800_12125 1.03e-105 326.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1X334@135614|Xanthomonadales 135614|Xanthomonadales JKL DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_915383_1 1415780.JPOG01000001_gene2187 2.51e-19 85.1 COG1309@1|root,COG1309@2|Bacteria,1R7QV@1224|Proteobacteria,1S8ES@1236|Gammaproteobacteria,1X76F@135614|Xanthomonadales 135614|Xanthomonadales K WHG domain - - - - - - - - - - - - TetR_N,WHG k59_915383_2 530564.Psta_1613 2.37e-59 188.0 COG0783@1|root,COG0783@2|Bacteria,2IZJP@203682|Planctomycetes 203682|Planctomycetes P Belongs to the Dps family - - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_130830_1 765913.ThidrDRAFT_2212 8.79e-71 226.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M20A family. ArgE subfamily - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_103603_27 765911.Thivi_0551 3.3e-301 830.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_756462_1 765911.Thivi_0537 8.2e-38 138.0 COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,1S13M@1236|Gammaproteobacteria,1WWSG@135613|Chromatiales 135613|Chromatiales S PFAM Alpha beta hydrolase of - - - - - - - - - - - - DUF900 k59_887150_1 525898.Sdel_1390 8.67e-69 221.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2YMCS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_429580_1 1168034.FH5T_00230 1.57e-93 282.0 COG0624@1|root,COG0624@2|Bacteria,4NE2G@976|Bacteroidetes,2FN2Z@200643|Bacteroidia 976|Bacteroidetes E Acetylornithine deacetylase argE - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_70475_1 1168034.FH5T_05325 2.89e-48 162.0 28PU4@1|root,2ZCF6@2|Bacteria,4NTXA@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_136469_1 472759.Nhal_3890 2.81e-30 115.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1WY4Z@135613|Chromatiales 135613|Chromatiales NU PFAM Fimbrial assembly - - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_103606_1 1537917.JU82_04610 3.26e-26 105.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2YNN2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_103606_2 1537917.JU82_04615 8.27e-24 93.6 COG0711@1|root,COG0711@2|Bacteria,1Q2G9@1224|Proteobacteria,42VN4@68525|delta/epsilon subdivisions,2YQBE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the ATPase B chain family atpF' - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_855170_2 1504981.KO116_1329 1.44e-19 87.4 COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,1S3T8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ribonuclease BN - - - - - - - - - - - - Virul_fac_BrkB k59_495642_1 96561.Dole_1296 1.47e-08 62.4 COG1216@1|root,COG1216@2|Bacteria,1N72Z@1224|Proteobacteria,42TKX@68525|delta/epsilon subdivisions 1224|Proteobacteria S Glycosyltransferase like family 2 - - - ko:K00786,ko:K16555 - - - - ko00000,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_756464_1 1158165.KB898874_gene1911 6.53e-11 64.7 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WXMA@135613|Chromatiales 135613|Chromatiales T Chemotaxis sensory transducer - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_169338_1 794903.OPIT5_02585 7.97e-65 213.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,46U8H@74201|Verrucomicrobia,3K8WM@414999|Opitutae 414999|Opitutae C Glucose sorbosone dehydrogenase - - - ko:K21430 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,GSDH k59_822557_1 1123270.ATUR01000002_gene2339 1.37e-49 172.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2K1R5@204457|Sphingomonadales 204457|Sphingomonadales S ABC1 family - - - - - - - - - - - - ABC1 k59_528714_1 243233.MCA0719 3.59e-66 204.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1XF5B@135618|Methylococcales 135618|Methylococcales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_985683_1 56110.Oscil6304_5843 7.07e-63 206.0 COG0297@1|root,COG0297@2|Bacteria,1G1YU@1117|Cyanobacteria,1H8IV@1150|Oscillatoriales 1117|Cyanobacteria G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA2 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_985683_2 563040.Saut_2134 1.85e-13 68.2 COG4106@1|root,COG4106@2|Bacteria,1QZ2S@1224|Proteobacteria,43CEU@68525|delta/epsilon subdivisions,2YTCB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Methyltransferase domain - - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25 k59_397544_1 187272.Mlg_0394 7.09e-100 304.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_332465_1 552811.Dehly_1677 9.69e-112 356.0 COG0507@1|root,COG0782@1|root,COG1112@1|root,COG0507@2|Bacteria,COG0782@2|Bacteria,COG1112@2|Bacteria 2|Bacteria L Superfamily I DNA and RNA helicases and helicase subunits - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,DUF559,GreA_GreB k59_691652_2 709032.Sulku_1191 2.5e-148 421.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2YNB3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L exodeoxyribonuclease III xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_691652_3 1120966.AUBU01000008_gene2383 2.58e-14 82.0 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47U6P@768503|Cytophagia 976|Bacteroidetes T SnoaL-like domain - - - - - - - - - - - - HATPase_c,HisKA,SnoaL_3 k59_855171_1 1249627.D779_0110 9.83e-219 632.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_953017_2 1049564.TevJSym_al00360 7.26e-06 47.4 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1J5ZK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolase gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_201124_1 387093.SUN_1496 4.17e-98 288.0 COG1943@1|root,COG1943@2|Bacteria,1RG4K@1224|Proteobacteria,42RWC@68525|delta/epsilon subdivisions,2YRM9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Transposase IS200 like - - - - - - - - - - - - - k59_887157_1 1165841.SULAR_01425 1.21e-20 89.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2YMCA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Methylenetetrahydrofolate reductase metF - - - - - - - - - - - MTHFR k59_920944_1 908612.HMPREF9720_0058 8.86e-66 222.0 COG0348@1|root,COG0348@2|Bacteria,4PJS0@976|Bacteroidetes,2FPJW@200643|Bacteroidia 976|Bacteroidetes C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 k59_169349_1 1116472.MGMO_182c00020 7.87e-12 68.6 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1XFC7@135618|Methylococcales 135618|Methylococcales L DNA RNA helicase, superfamily II - - - - - - - - - - - - Helicase_C,SNF2_N k59_169349_2 765420.OSCT_2087 2.24e-23 98.6 COG0326@1|root,COG0326@2|Bacteria,2G9ND@200795|Chloroflexi 200795|Chloroflexi O Molecular chaperone. Has ATPase activity - - - - - - - - - - - - - k59_593144_1 1506994.JNLQ01000002_gene2255 2.63e-06 48.1 2EVBX@1|root,33NSE@2|Bacteria,1VKHC@1239|Firmicutes,24WCF@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_724178_1 1049564.TevJSym_ak00810 7.28e-102 310.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1J4HB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_495664_1 1265505.ATUG01000003_gene633 5.02e-71 224.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,42MQV@68525|delta/epsilon subdivisions,2WIZC@28221|Deltaproteobacteria,2MIQG@213118|Desulfobacterales 28221|Deltaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_985701_1 1172190.M947_11010 3.15e-45 158.0 COG0475@1|root,COG0475@2|Bacteria,1N2RV@1224|Proteobacteria,43B2N@68525|delta/epsilon subdivisions,2YT5E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_789635_1 452637.Oter_0785 1.18e-73 231.0 COG0379@1|root,COG0379@2|Bacteria,46SA1@74201|Verrucomicrobia,3K7P4@414999|Opitutae 414999|Opitutae H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_136493_1 749222.Nitsa_0289 2.92e-54 183.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2YMC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU twitching motility protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_103640_1 880072.Desac_2165 2.97e-14 67.4 COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MQFR@213462|Syntrophobacterales 28221|Deltaproteobacteria C Desulfoferrodoxin, ferrous iron-binding dfx - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrod_N,Desulfoferrodox k59_103640_2 96561.Dole_2647 1.33e-64 201.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2MHUF@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Rubrerythrin rbr GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - - - - - - - - - - Rubrerythrin k59_332484_1 1415779.JOMH01000001_gene178 3.27e-27 114.0 2ASXF@1|root,31ID0@2|Bacteria,1RM30@1224|Proteobacteria,1S8I2@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_463503_1 305900.GV64_16165 6.48e-77 243.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1XHYF@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_561406_1 387093.SUN_1906 7.33e-114 351.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2YMNT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_593165_1 395493.BegalDRAFT_0425 1.49e-88 270.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C small subunit hyaA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040 NiFe_hyd_SSU_C,Oxidored_q6 k59_1018629_1 13333.ERM97892 6.37e-308 841.0 COG1850@1|root,2QTI9@2759|Eukaryota,37HQX@33090|Viridiplantae,3GDC3@35493|Streptophyta 35493|Streptophyta G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site rbcL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.1.3.15,4.1.1.39,6.4.1.2 ko:K01601,ko:K01963 ko00061,ko00620,ko00630,ko00640,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00630,map00640,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00165,M00166,M00376,M00532 R00024,R00742,R03140,R04386 RC00040,RC00172,RC00253,RC00367,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_887181_1 745411.B3C1_10727 3.29e-75 244.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1J8W5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S oligopeptide transporter - - - - - - - - - - - - OPT k59_822600_1 335543.Sfum_3021 2.5e-79 241.0 COG1896@1|root,COG1896@2|Bacteria,1R71H@1224|Proteobacteria,42NGN@68525|delta/epsilon subdivisions,2WKMF@28221|Deltaproteobacteria,2MRJY@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM metal-dependent phosphohydrolase, HD sub domain - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_266259_1 1123261.AXDW01000001_gene1445 2.97e-79 243.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales 135614|Xanthomonadales V Part of the ABC transporter complex LolCDE involved in the translocation of lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_266259_2 1283300.ATXB01000001_gene1476 2.62e-19 86.3 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1XE02@135618|Methylococcales 135618|Methylococcales M TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_429616_1 1168034.FH5T_15275 1.18e-289 795.0 COG1904@1|root,COG1904@2|Bacteria,4NFHS@976|Bacteroidetes,2FMMW@200643|Bacteroidia 976|Bacteroidetes G glucuronate isomerase uxaC - 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - - UxaC k59_495711_1 981369.JQMJ01000004_gene2507 2.75e-88 274.0 COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,2NHP0@228398|Streptacidiphilus 201174|Actinobacteria S GTP1/OBG obg GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k59_724214_1 396588.Tgr7_2778 6.44e-89 292.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_953056_1 572544.Ilyop_0121 3.75e-25 100.0 COG0679@1|root,COG0679@2|Bacteria,37AKH@32066|Fusobacteria 32066|Fusobacteria S Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_660485_2 1165841.SULAR_06553 4.03e-46 159.0 COG3660@1|root,COG3660@2|Bacteria,1RC47@1224|Proteobacteria,42R32@68525|delta/epsilon subdivisions,2YNVT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mitochondrial fission ELM1 - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_496777_1 400682.PAC_15711221 7.48e-48 167.0 COG0316@1|root,KOG1120@2759|Eukaryota,3A9KT@33154|Opisthokonta,3BV66@33208|Metazoa 33208|Metazoa P Iron-sulphur cluster biosynthesis - - - ko:K22063 - - - - ko00000,ko03029 - - - Fe-S_biosyn k59_235037_1 481448.Minf_0748 0.000112 45.1 COG1044@1|root,COG1044@2|Bacteria,46SAD@74201|Verrucomicrobia,37GE9@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,LpxD k59_235037_2 469618.FVAG_01956 8.23e-14 72.4 COG2825@1|root,COG2825@2|Bacteria,37AAK@32066|Fusobacteria 32066|Fusobacteria M Outer membrane protein (OmpH-like) - - - ko:K06142 - - - - ko00000 - - - OmpH k59_235037_3 572544.Ilyop_0608 9.34e-142 424.0 COG4775@1|root,COG4775@2|Bacteria,378TB@32066|Fusobacteria 32066|Fusobacteria M Outer membrane protein, OMP85 family - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_856162_1 1304885.AUEY01000004_gene911 1.25e-60 204.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42Z3K@68525|delta/epsilon subdivisions,2WTSP@28221|Deltaproteobacteria,2MMNN@213118|Desulfobacterales 28221|Deltaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,AcylCoA_DH_N k59_823481_1 326298.Suden_0779 1.15e-34 127.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2YTQI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_823481_2 1172190.M947_01480 1.28e-37 132.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2YMFJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_71621_1 702113.PP1Y_AT11717 2.93e-18 83.2 COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2TRBF@28211|Alphaproteobacteria,2K261@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_692637_1 717773.Thicy_0702 4.71e-64 202.0 COG0564@1|root,COG0564@2|Bacteria,1RDAG@1224|Proteobacteria,1S406@1236|Gammaproteobacteria,4626S@72273|Thiotrichales 72273|Thiotrichales J RNA pseudouridylate synthase - - 5.4.99.28,5.4.99.29 ko:K06177 - - - - ko00000,ko01000,ko03009,ko03016 - - - PseudoU_synth_2 k59_267124_1 1226994.AMZB01000118_gene3183 3.51e-19 86.7 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RNQ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Mate efflux family protein yeeO GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006862,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015215,GO:0015230,GO:0015605,GO:0015711,GO:0015748,GO:0015833,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0034220,GO:0035350,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0044610,GO:0051179,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1901679,GO:1904680 - - - - - - - - - - MatE k59_267124_2 1121940.AUDZ01000005_gene1900 3.46e-57 192.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1XHRK@135619|Oceanospirillales 135619|Oceanospirillales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_790283_1 342610.Patl_2842 5.73e-10 65.5 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_790283_2 367737.Abu_0867 5.98e-40 138.0 COG2236@1|root,COG2236@2|Bacteria,1Q1HY@1224|Proteobacteria,42TR4@68525|delta/epsilon subdivisions,2YP9B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F phosphoribosyltransferase gpt - 2.4.2.22 ko:K00769 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01229,R02142 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_921961_1 1319815.HMPREF0202_02028 1.2e-64 208.0 COG0368@1|root,COG0368@2|Bacteria,379H2@32066|Fusobacteria 32066|Fusobacteria H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_921961_2 1122173.AXVL01000009_gene980 4.07e-43 148.0 COG0406@1|root,COG0406@2|Bacteria,378IR@32066|Fusobacteria 32066|Fusobacteria G phosphoglycerate mutase - - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_562318_1 929558.SMGD1_0657 9.96e-55 179.0 COG1639@1|root,COG1639@2|Bacteria,1Q1C5@1224|Proteobacteria,42T98@68525|delta/epsilon subdivisions,2YPNT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_38377_1 352165.HMPREF7215_1308 5.07e-26 99.0 COG2158@1|root,COG2158@2|Bacteria 2|Bacteria S Cysteine-rich small domain cbiA - - ko:K07162 - - - - ko00000 - - - zf-like k59_38377_2 1313304.CALK_0144 6.06e-98 300.0 COG1226@1|root,COG1226@2|Bacteria 2|Bacteria P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) kch - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_38377_3 469618.FVAG_01812 1.55e-23 96.3 COG1489@1|root,COG1489@2|Bacteria,37918@32066|Fusobacteria 32066|Fusobacteria S Belongs to the SfsA family sfsA - - ko:K06206 - - - - ko00000 - - - SfsA k59_856177_1 765912.Thimo_0508 4.92e-87 261.0 COG1387@1|root,COG1387@2|Bacteria 2|Bacteria E zinc ion binding hisK - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP k59_170306_1 156889.Mmc1_0403 1.42e-42 159.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2UP6H@28211|Alphaproteobacteria 28211|Alphaproteobacteria T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3 k59_986774_1 713586.KB900536_gene465 9.06e-58 191.0 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales 135613|Chromatiales Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_696157_1 489825.LYNGBM3L_74460 7.54e-08 60.5 COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria 1117|Cyanobacteria Q Beta-ketoacyl synthase, N-terminal domain - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2,AMP-binding,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Sulfotransfer_3,ketoacyl-synt k59_75673_1 469618.FVAG_02728 1.13e-218 612.0 COG0055@1|root,COG0055@2|Bacteria,3794W@32066|Fusobacteria 32066|Fusobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_75673_2 1321820.HMPREF1983_00724 4.81e-19 84.3 COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,4HKHS@91061|Bacilli,3WEVV@539002|Bacillales incertae sedis 91061|Bacilli C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_270445_1 563040.Saut_1975 2.08e-16 78.2 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2YN8R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_270445_2 709032.Sulku_2359 7.25e-94 279.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,42NGT@68525|delta/epsilon subdivisions,2YN0R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_566016_1 929558.SMGD1_2186 4.72e-178 508.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42MJ7@68525|delta/epsilon subdivisions,2YMWU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F COG0402 Cytosine deaminase and related metal-dependent orf1 - 3.5.4.40 ko:K20810 ko00130,ko01110,map00130,map01110 - R10695 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_566016_2 1165841.SULAR_01673 6.81e-72 228.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2YMK1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria OU signal peptide peptidase SppA, 36K type sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_859180_1 1045855.DSC_13320 8.87e-09 61.2 COG2353@1|root,COG2353@2|Bacteria,1RHEW@1224|Proteobacteria,1S6XG@1236|Gammaproteobacteria,1X60U@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_925800_1 629265.PMA4326_13949 1.84e-16 83.6 COG3904@1|root,COG3904@2|Bacteria,1R3Y5@1224|Proteobacteria 1224|Proteobacteria S periplasmic protein - - - - - - - - - - - - - k59_337805_1 626887.J057_09196 2.43e-49 175.0 COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria,4664T@72275|Alteromonadaceae 1236|Gammaproteobacteria V ABC transporter transmembrane region ygaD - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_433994_1 1347392.CCEZ01000004_gene745 9.99e-83 265.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae 186801|Clostridia P Belongs to the sulfur carrier protein TusA family cdr - - - - - - - - - - - DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA k59_41219_2 981336.F944_02940 3.95e-77 246.0 COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,1RRHZ@1236|Gammaproteobacteria,3NKE5@468|Moraxellaceae 1236|Gammaproteobacteria S Fic/DOC family - - - - - - - - - - - - Fic,HTH_11,HTH_24 k59_827002_1 697282.Mettu_1576 0.000258 54.7 COG0689@1|root,COG0823@1|root,COG2202@1|root,COG2304@1|root,COG2931@1|root,COG3188@1|root,COG3210@1|root,COG3898@1|root,COG4932@1|root,COG0689@2|Bacteria,COG0823@2|Bacteria,COG2202@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3188@2|Bacteria,COG3210@2|Bacteria,COG3898@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XFUS@135618|Methylococcales 135618|Methylococcales QU COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4347 k59_664350_1 864051.BurJ1DRAFT_0810 2.94e-134 394.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,1KJ4C@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Alanine dehydrogenase/PNT, N-terminal domain pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_990888_1 1469245.JFBG01000023_gene1243 2.3e-12 69.7 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_75687_1 502025.Hoch_5971 4.6e-98 315.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding pucD - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_206345_2 1120999.JONM01000007_gene1869 1.08e-14 72.8 COG3744@1|root,COG3744@2|Bacteria,1RJ4K@1224|Proteobacteria,2VTJR@28216|Betaproteobacteria 28216|Betaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_173837_1 1121403.AUCV01000002_gene549 1.13e-19 88.6 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2MIQM@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_467855_1 935845.JADQ01000001_gene1149 1.07e-41 157.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli,26QP7@186822|Paenibacillaceae 91061|Bacilli G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21,3.2.1.52 ko:K01207,ko:K05349 ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501 M00628 R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko00002,ko01000 - GH3 - CBM_6,Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_369893_1 521393.JH806632_gene1121 4.52e-08 57.8 COG1190@1|root,COG2898@1|root,COG1190@2|Bacteria,COG2898@2|Bacteria,2GKE0@201174|Actinobacteria,4D4G0@85005|Actinomycetales 201174|Actinobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family - - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon k59_108538_1 1049564.TevJSym_ai00210 1.87e-69 227.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1J4VX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_990891_1 639030.JHVA01000001_gene3479 1.14e-05 50.4 COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JHXZ@204432|Acidobacteriia 204432|Acidobacteriia S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_598556_2 2340.JV46_11840 3.74e-14 72.4 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1J4DP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f k59_566043_1 519989.ECTPHS_02976 4.85e-65 213.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_534497_1 329726.AM1_0469 5.63e-16 82.4 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG2202@2|Bacteria,1GHFQ@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_402524_1 335543.Sfum_0853 1.28e-96 297.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MR37@213462|Syntrophobacterales 28221|Deltaproteobacteria K two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_696908_2 553219.CAMSH0001_1682 4.77e-27 107.0 COG0614@1|root,COG0614@2|Bacteria,1NVK4@1224|Proteobacteria,42MBT@68525|delta/epsilon subdivisions,2YMTN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_434681_3 981384.AEYW01000024_gene3937 4.8e-07 53.5 COG0848@1|root,COG0848@2|Bacteria,1RHQ3@1224|Proteobacteria,2U912@28211|Alphaproteobacteria 28211|Alphaproteobacteria U COG0848 Biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_434681_4 1122951.ATUE01000007_gene624 3.06e-15 77.8 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,3NKFJ@468|Moraxellaceae 1236|Gammaproteobacteria U MotA/TolQ/ExbB proton channel family exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_434681_5 525146.Ddes_1512 9.61e-07 57.0 COG0810@1|root,COG0810@2|Bacteria,1N94H@1224|Proteobacteria,42V43@68525|delta/epsilon subdivisions,2WRRA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_434681_6 1121403.AUCV01000052_gene2560 5.56e-44 151.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42NRB@68525|delta/epsilon subdivisions,2WJHF@28221|Deltaproteobacteria,2MJI6@213118|Desulfobacterales 28221|Deltaproteobacteria HP ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_859905_1 1244869.H261_04450 2.45e-127 369.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,2JPW0@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1023450_1 749222.Nitsa_1308 1.4e-113 347.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2YMHZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_566747_1 1349822.NSB1T_14355 5.72e-18 82.4 COG1011@1|root,COG1011@2|Bacteria,4NQT8@976|Bacteroidetes,2FMXN@200643|Bacteroidia,22Y9W@171551|Porphyromonadaceae 976|Bacteroidetes S Haloacid dehalogenase-like hydrolase yihX - 3.1.3.10 ko:K07025,ko:K20866 ko00010,ko01120,map00010,map01120 - R00947 RC00078 ko00000,ko00001,ko01000 - - - HAD_2 k59_566747_2 1168034.FH5T_06220 5.64e-58 191.0 COG0652@1|root,COG0652@2|Bacteria,4NMJF@976|Bacteroidetes,2FWT5@200643|Bacteroidia 976|Bacteroidetes O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - - - - - - - - - - - Pro_isomerase k59_402532_1 572544.Ilyop_0241 1.99e-172 507.0 COG0653@1|root,COG0653@2|Bacteria,378NS@32066|Fusobacteria 32066|Fusobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_991619_2 247490.KSU1_B0678 2.55e-188 534.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein nirJ - - ko:K22226 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_991619_3 552811.Dehly_0450 1.07e-103 317.0 COG0535@1|root,COG0535@2|Bacteria,2G5XT@200795|Chloroflexi 200795|Chloroflexi C PFAM Radical SAM domain protein - - - ko:K22227 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_991619_4 1121451.DESAM_22935 1.53e-26 110.0 COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,42RM4@68525|delta/epsilon subdivisions,2WNU8@28221|Deltaproteobacteria,2MBGM@213115|Desulfovibrionales 28221|Deltaproteobacteria K SMART Transcription regulator, AsnC-type nirD - - - - - - - - - - - HTH_AsnC-type k59_991619_5 994573.T472_0206170 0.0 1202.0 COG0376@1|root,COG0376@2|Bacteria,1TQDA@1239|Firmicutes,24DM7@186801|Clostridia,36HFJ@31979|Clostridiaceae 186801|Clostridia P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_991619_6 526218.Sterm_2260 9.62e-56 177.0 COG0432@1|root,COG0432@2|Bacteria 2|Bacteria S Uncharacterised protein family UPF0047 yugU - - - - - - - - - - - UPF0047 k59_991619_7 572544.Ilyop_0732 2.38e-270 750.0 COG0733@1|root,COG0733@2|Bacteria,378ZP@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_728798_2 768671.ThimaDRAFT_3040 3.66e-65 206.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1WXPI@135613|Chromatiales 135613|Chromatiales F phosphoribosyltransferase pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_728798_3 1249627.D779_0658 1.17e-163 466.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1WWU0@135613|Chromatiales 135613|Chromatiales F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_728798_4 1049564.TevJSym_bn00140 3.45e-182 521.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1J8GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Amidohydrolase family pyrC - 3.5.2.3,3.5.2.5 ko:K01465,ko:K01466 ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120 M00051,M00546 R01993,R02425 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_728798_5 1049564.TevJSym_bn00150 2.65e-146 419.0 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6 k59_728798_6 686578.AFFX01000003_gene185 2.98e-188 532.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU twitching motility protein pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_728798_7 1049564.TevJSym_am00210 3.91e-225 623.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1J4KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein, pilus retraction ATPase PilT pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_728798_8 768671.ThimaDRAFT_2722 5.16e-85 259.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,1WWUW@135613|Chromatiales 135613|Chromatiales S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_728798_9 1249627.D779_0683 2.3e-101 304.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1WWVS@135613|Chromatiales 135613|Chromatiales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_728798_10 264730.PSPPH_0466 6.5e-40 141.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1Z7IC@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S YGGT family yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_728798_11 323261.Noc_3000 3.76e-32 115.0 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,1WYTV@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0235 family - - - ko:K09131 - - - - ko00000 - - - DUF167 k59_728798_12 1049564.TevJSym_am00160 1.51e-253 721.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1J9QI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_728798_13 555778.Hneap_1837 2.63e-196 554.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1WYIB@135613|Chromatiales 135613|Chromatiales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metXS - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_728798_14 1198232.CYCME_0044 2.8e-77 237.0 COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,1S24V@1236|Gammaproteobacteria,460IK@72273|Thiotrichales 72273|Thiotrichales Q Methionine biosynthesis protein MetW - - - - - - - - - - - - MetW k59_728798_15 2340.JV46_21830 1.61e-28 109.0 2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1J6SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4426) PP5099 - - - - - - - - - - - DUF4426 k59_728798_16 1049564.TevJSym_ak00870 4.07e-137 398.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1J4U9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P antiporter yrbG - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_728798_17 765911.Thivi_2229 1.62e-148 428.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales 135613|Chromatiales M Arabinose 5-phosphate isomerase - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_728798_18 768671.ThimaDRAFT_1391 9.24e-65 203.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1WY5Q@135613|Chromatiales 135613|Chromatiales S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_728798_19 1198232.CYCME_0817 1.51e-37 135.0 COG3117@1|root,COG3117@2|Bacteria,1NGCC@1224|Proteobacteria,1SGDP@1236|Gammaproteobacteria,463B5@72273|Thiotrichales 72273|Thiotrichales S Lipopolysaccharide-assembly, LptC-related - - - ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC k59_728798_20 981384.AEYW01000017_gene3101 3.75e-07 55.1 COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria,4NC79@97050|Ruegeria 28211|Alphaproteobacteria S OstA-like protein lptA - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_728798_21 697282.Mettu_2482 7.16e-107 316.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1XEEF@135618|Methylococcales 135618|Methylococcales S Branched-chain amino acid ATP-binding cassette transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_728798_22 1049564.TevJSym_ak00810 1.93e-217 615.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1J4HB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_728798_23 1049564.TevJSym_ak00800 2.28e-49 159.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1J6HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1544 Ribosome-associated protein Y (PSrp-1) yhbH GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_728798_24 187272.Mlg_2232 6.52e-53 172.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1WYAA@135613|Chromatiales 135613|Chromatiales G PTS IIA-like nitrogen-regulatory protein PtsN - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_728798_25 2340.JV46_25920 3.86e-98 299.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1J7PM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_728798_26 1049564.TevJSym_ak00770 8.21e-123 359.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1J528@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Displays ATPase and GTPase activities rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_728798_27 1049564.TevJSym_ak00760 8.71e-42 142.0 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,1RNAT@1236|Gammaproteobacteria,1J9A2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G PTS system fructose IIA component manX GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0009987,GO:0015144,GO:0015145,GO:0015149,GO:0015578,GO:0015749,GO:0015761,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0022870,GO:0031224,GO:0031226,GO:0034219,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098657,GO:0098704,GO:0098708,GO:0098739,GO:1904659 2.7.1.191 ko:K02793,ko:K02794 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 - iAPECO1_1312.APECO1_874,iECOK1_1307.ECOK1_1934,iECS88_1305.ECS88_1869,iPC815.YPO1758,iUMN146_1321.UM146_08085,iUTI89_1310.UTI89_C2014 EIIA-man,PTSIIB_sorb k59_728798_28 1122164.JHWF01000001_gene1913 1.66e-27 102.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SX88@1236|Gammaproteobacteria,1JEY3@118969|Legionellales 118969|Legionellales G PTS HPr component phosphorylation site ptsH - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_728798_29 472759.Nhal_0558 4.14e-104 313.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1WY5A@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_728798_30 247490.KSU1_C0523 6.38e-09 62.8 COG1277@1|root,COG1277@2|Bacteria,2J0HW@203682|Planctomycetes 203682|Planctomycetes S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_728798_31 1283300.ATXB01000001_gene1785 1.15e-129 389.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1XEHX@135618|Methylococcales 135618|Methylococcales N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_728798_32 243233.MCA3075 1.22e-21 96.3 2E2KI@1|root,32XPU@2|Bacteria,1RH64@1224|Proteobacteria,1RYC7@1236|Gammaproteobacteria,1XGH6@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 k59_728798_33 1042377.AFPJ01000028_gene2277 4.22e-113 334.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,464SQ@72275|Alteromonadaceae 1236|Gammaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_728798_34 1540221.JQNI01000002_gene2813 3.27e-54 186.0 COG0730@1|root,COG2391@1|root,COG0730@2|Bacteria,COG2391@2|Bacteria,1WIAC@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_728798_35 160488.PP_3296 5.85e-09 58.9 COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,1S8UB@1236|Gammaproteobacteria,1YYWA@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Transporter Component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_728798_36 870187.Thini_2059 6.65e-218 608.0 28IVT@1|root,2Z8U5@2|Bacteria,1R7G9@1224|Proteobacteria,1S02A@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_728798_37 1049564.TevJSym_ai00610 5.16e-18 77.8 COG3313@1|root,COG3313@2|Bacteria 2|Bacteria S Fe-S protein - - - ko:K06938 - - - - ko00000 - - - DUF1289 k59_728798_38 1286631.X805_39740 4.9e-42 139.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,1KMCZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria C 4Fe-4S binding domain fdx1 - - - - - - - - - - - Fer4,Fer4_7 k59_728798_39 187272.Mlg_2655 1.21e-64 202.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1WY42@135613|Chromatiales 135613|Chromatiales H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_728798_40 1049564.TevJSym_aa00900 4.8e-69 215.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1J66E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_728798_41 1049564.TevJSym_aa00890 9.71e-177 508.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1J6RI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Insulinase (Peptidase family M16) - - 2.7.7.6 ko:K00960,ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_728798_42 2340.JV46_28010 8.01e-186 533.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1JC0J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_728798_44 1249627.D779_0976 2.16e-153 444.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1WW5G@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_728798_45 754476.Q7A_1267 1.16e-103 305.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,4604Q@72273|Thiotrichales 72273|Thiotrichales D TIGRFAM Cell division ATP-binding protein FtsE - - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_728798_46 1049564.TevJSym_aa00850 5.66e-110 330.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1J4H6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944 - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_728798_47 765910.MARPU_00790 2.31e-130 378.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1WWRE@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_728798_48 395493.BegalDRAFT_1266 7.47e-170 484.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,45ZQT@72273|Thiotrichales 72273|Thiotrichales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - - - - - - - - - - - DAHP_synth_1 k59_728798_49 1049564.TevJSym_aa00820 1.68e-81 249.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1J5P0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858 AAA_26 k59_541861_13 1163617.SCD_n02386 1.66e-21 96.7 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM Forkhead-associated protein - - - - - - - - - - - - FHA,Yop-YscD_cpl k59_541861_14 519989.ECTPHS_06897 7.03e-59 195.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1SZ5G@1236|Gammaproteobacteria,1WWSY@135613|Chromatiales 135613|Chromatiales T PFAM protein phosphatase - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2,SpoIIE k59_541861_15 156889.Mmc1_0444 7.58e-37 142.0 COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria 1224|Proteobacteria O DSBA oxidoreductase MA20_20720 - - - - - - - - - - - DSBA,Thioredoxin_4 k59_541861_16 857087.Metme_3848 2.34e-52 172.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1XEYS@135618|Methylococcales 135618|Methylococcales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_541861_17 765911.Thivi_3723 7.84e-133 385.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1WW40@135613|Chromatiales 135613|Chromatiales L TIGRFAM Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_541861_18 1282876.BAOK01000001_gene2600 4.21e-56 179.0 COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,4BS5F@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Putative zinc- or iron-chelating domain MA20_15575 - - ko:K09160 - - - - ko00000 - - - CxxCxxCC k59_541861_20 317025.Tcr_1929 8.82e-90 278.0 COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,460S7@72273|Thiotrichales 72273|Thiotrichales T HPP family - - - - - - - - - - - - HPP k59_541861_21 670307.HYPDE_28383 2.42e-282 804.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2TR2N@28211|Alphaproteobacteria,3N80D@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_541861_22 768671.ThimaDRAFT_3198 1.28e-188 530.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1WX20@135613|Chromatiales 135613|Chromatiales O TIGRFAM hydrogenase expression formation protein HypE - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_541861_23 1485545.JQLW01000005_gene917 1.92e-202 568.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria 1224|Proteobacteria O Belongs to the HypD family hypD - - ko:K04654 - - - - ko00000 - - iAF987.Gmet_0117 HypD k59_541861_24 768671.ThimaDRAFT_3200 5.74e-25 95.9 COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,1SCGX@1236|Gammaproteobacteria,1WZ96@135613|Chromatiales 135613|Chromatiales O TIGRFAM hydrogenase assembly chaperone hypC hupF - - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_541861_25 1485545.JQLW01000005_gene919 2.88e-121 355.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria 1224|Proteobacteria KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG hypB GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010467,GO:0016151,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:1901564 - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_541861_26 857087.Metme_1765 4.79e-46 151.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,1XFP3@135618|Methylococcales 135618|Methylococcales C Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_541861_28 318167.Sfri_1939 9.06e-92 305.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,2QAI3@267890|Shewanellaceae 1236|Gammaproteobacteria NT PFAM histidine kinase, HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_3 k59_541861_32 1458275.AZ34_13775 6.34e-61 191.0 COG2050@1|root,COG2050@2|Bacteria,1QU0P@1224|Proteobacteria,2VTB0@28216|Betaproteobacteria 28216|Betaproteobacteria Q Putative thioesterase (yiiD_Cterm) - - - - - - - - - - - - YiiD_C k59_541861_33 1238450.VIBNISOn1_1760005 2.54e-79 248.0 COG2207@1|root,COG2207@2|Bacteria,1R6WN@1224|Proteobacteria,1RRR4@1236|Gammaproteobacteria,1XVD4@135623|Vibrionales 135623|Vibrionales K helix_turn_helix, arabinose operon control protein - - - ko:K20968 ko02025,map02025 - - - ko00000,ko00001,ko03000 - - - HTH_18 k59_541861_34 1238450.VIBNISOn1_1760006 5.15e-40 134.0 COG1359@1|root,COG1359@2|Bacteria,1NDZZ@1224|Proteobacteria,1SUS3@1236|Gammaproteobacteria,1Y1HB@135623|Vibrionales 135623|Vibrionales S (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - - - - - - - - - - - k59_541861_36 1123247.AUIJ01000018_gene2703 8.5e-85 271.0 2DBS0@1|root,2ZANT@2|Bacteria,1R8Y3@1224|Proteobacteria,2U146@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_541861_39 1121413.JMKT01000002_gene2645 7.24e-27 102.0 COG1504@1|root,COG1504@2|Bacteria,1NCBP@1224|Proteobacteria,42VUI@68525|delta/epsilon subdivisions,2WRJY@28221|Deltaproteobacteria,2MDIW@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 k59_541861_42 717774.Marme_0128 8.29e-62 197.0 COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,1SA2T@1236|Gammaproteobacteria,1XKVA@135619|Oceanospirillales 135619|Oceanospirillales O HupE / UreJ protein - - - ko:K03192 - - - - ko00000 - - - HupE_UreJ k59_541861_43 2340.JV46_11730 5.36e-37 130.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1J6NQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases hit1 - - - - - - - - - - - HIT k59_541861_44 1073999.BN137_2732 2.69e-34 125.0 COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,1RR2X@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0791 Cell wall-associated hydrolases (invasion-associated proteins) spr GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009254,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564 3.4.17.13 ko:K13694 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 k59_541861_45 2340.JV46_06860 4.9e-224 628.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1J58A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0826 Collagenase and related proteases yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_541861_46 913325.N799_05440 1.09e-46 159.0 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1S8HN@1236|Gammaproteobacteria,1X62E@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_541861_48 1049564.TevJSym_aa01140 4.11e-55 178.0 COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,1S2AY@1236|Gammaproteobacteria,1J762@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Phosphoglycerate mutase family sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_541861_49 42565.FP66_06760 7.31e-150 436.0 COG0391@1|root,COG0391@2|Bacteria,1NW3K@1224|Proteobacteria,1RQP9@1236|Gammaproteobacteria,1XJ3Y@135619|Oceanospirillales 135619|Oceanospirillales S Uncharacterised protein family UPF0052 - - - - - - - - - - - - UPF0052 k59_541861_50 1049564.TevJSym_aa00430 9.55e-150 476.0 COG4191@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1T5JB@1236|Gammaproteobacteria 1236|Gammaproteobacteria T PAS domain - - - - - - - - - - - - - k59_541861_51 1121028.ARQE01000010_gene1066 1.62e-96 293.0 COG2951@1|root,COG2951@2|Bacteria,1MVY0@1224|Proteobacteria,2TTVI@28211|Alphaproteobacteria,2PKWX@255475|Aurantimonadaceae 28211|Alphaproteobacteria M Transglycosylase SLT domain MA20_41385 - - - - - - - - - - - SLT_2 k59_541861_52 1188252.AJYK01000015_gene1844 7.11e-12 68.9 COG2204@1|root,COG2204@2|Bacteria,1QUG8@1224|Proteobacteria,1T1Y0@1236|Gammaproteobacteria,1XT04@135623|Vibrionales 135623|Vibrionales T COG0784 FOG CheY-like receiver rssB - - - - - - - - - - - Response_reg k59_541861_53 1049564.TevJSym_ax00090 2.17e-282 791.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1J4ET@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_541861_54 1049564.TevJSym_ax00110 3.86e-122 353.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_541861_55 387092.NIS_0049 1.84e-51 167.0 2B5BG@1|root,31Y5N@2|Bacteria,1RJ1N@1224|Proteobacteria,42TPY@68525|delta/epsilon subdivisions,2YPZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_541861_56 580332.Slit_0803 7.44e-21 86.7 COG1433@1|root,COG1433@2|Bacteria,1N7S0@1224|Proteobacteria,2WG9K@28216|Betaproteobacteria 28216|Betaproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_541861_57 243233.MCA2483 2.58e-208 586.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1XE3G@135618|Methylococcales 135618|Methylococcales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_541861_58 349521.HCH_00128 1.51e-80 248.0 28NH4@1|root,2ZBJ2@2|Bacteria,1N1V3@1224|Proteobacteria,1SPNH@1236|Gammaproteobacteria,1XPED@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_541861_59 1120948.KB903243_gene2321 1.28e-36 145.0 COG1864@1|root,COG1864@2|Bacteria 2|Bacteria F neuron death in response to oxidative stress - - - ko:K01173 ko04210,map04210 - - - ko00000,ko00001,ko03029 - - - Endonuclea_NS_2,Endonuclease_NS,Excalibur k59_541861_62 679926.Mpet_2494 2.68e-127 376.0 COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2NAAK@224756|Methanomicrobia 224756|Methanomicrobia S radical SAM domain - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_541861_65 1121351.AUAP01000003_gene234 1.01e-47 161.0 2BVDV@1|root,32QTT@2|Bacteria,1RI1S@1224|Proteobacteria,2VSKI@28216|Betaproteobacteria,2KRHF@206351|Neisseriales 206351|Neisseriales - - - - - - - - - - - - - - - k59_541861_66 323848.Nmul_A1497 3.37e-254 703.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,3726F@32003|Nitrosomonadales 28216|Betaproteobacteria E Cys/Met metabolism PLP-dependent enzyme metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_541861_67 118168.MC7420_7722 4.16e-37 130.0 COG0517@1|root,COG0642@1|root,COG0784@1|root,COG4251@1|root,COG0517@2|Bacteria,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1G09B@1117|Cyanobacteria,1H82F@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,GAF_3,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_541861_69 580332.Slit_2185 1.28e-179 503.0 COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,2VN74@28216|Betaproteobacteria 28216|Betaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_541861_70 765913.ThidrDRAFT_3383 4.38e-204 588.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1WXAB@135613|Chromatiales 135613|Chromatiales P TrkA-N domain - - - - - - - - - - - - Ion_trans_2,TrkA_N k59_541861_71 768671.ThimaDRAFT_4361 6.48e-60 187.0 2AHT8@1|root,3185S@2|Bacteria,1RH98@1224|Proteobacteria,1S7UG@1236|Gammaproteobacteria,1WY6X@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_541861_73 1049564.TevJSym_ab00030 0.0 1222.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1J4PP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_541861_74 83406.HDN1F_04230 3.01e-161 470.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains cbrB - - - - - - - - - - - Response_reg,Sigma54_activat k59_541861_75 1049564.TevJSym_az00050 9.01e-92 280.0 COG5036@1|root,COG5036@2|Bacteria,1RG06@1224|Proteobacteria 1224|Proteobacteria P VTC domain - - - - - - - - - - - - VTC k59_541861_77 1049564.TevJSym_az00030 9.58e-119 375.0 COG0845@1|root,COG0845@2|Bacteria,1R8YY@1224|Proteobacteria 1224|Proteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_541861_78 177437.HRM2_21160 2.03e-78 242.0 COG1285@1|root,COG1285@2|Bacteria,1RAIG@1224|Proteobacteria,42T1T@68525|delta/epsilon subdivisions,2WPMM@28221|Deltaproteobacteria,2MMH8@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 k59_541861_79 991905.SL003B_2901 1.69e-100 298.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,4BPTM@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria KT Transcriptional regulatory protein, C terminal ragA GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_541861_80 573370.DMR_37850 2.14e-83 271.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42SW9@68525|delta/epsilon subdivisions,2WPN3@28221|Deltaproteobacteria,2M9KZ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_836089_1 1232437.KL662077_gene1840 1.78e-81 256.0 COG0569@1|root,COG0569@2|Bacteria,1NSUV@1224|Proteobacteria,42YVZ@68525|delta/epsilon subdivisions,2WUAK@28221|Deltaproteobacteria,2MMQR@213118|Desulfobacterales 28221|Deltaproteobacteria P TrkA-N domain - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_967031_1 1182590.BN5_01389 7.09e-75 241.0 COG2610@1|root,COG2610@2|Bacteria,1N2VU@1224|Proteobacteria,1RNCQ@1236|Gammaproteobacteria,1YIZH@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria EG GntP family permease - - - - - - - - - - - - GntP_permease k59_836095_1 519989.ECTPHS_04990 1.39e-109 338.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_117261_1 1033810.HLPCO_000211 2.9e-13 69.3 COG0392@1|root,COG0392@2|Bacteria 2|Bacteria M lysyltransferase activity mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_117261_2 1033810.HLPCO_000212 9.66e-64 215.0 COG0438@1|root,COG1409@1|root,COG0438@2|Bacteria,COG1409@2|Bacteria,2NPWY@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1,Metallophos k59_278845_1 572544.Ilyop_0867 1.15e-27 111.0 COG0728@1|root,COG0728@2|Bacteria,3789R@32066|Fusobacteria 32066|Fusobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_278845_2 572544.Ilyop_0868 5.43e-32 123.0 COG0827@1|root,COG0827@2|Bacteria,379CB@32066|Fusobacteria 32066|Fusobacteria L TaqI-like C-terminal specificity domain - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - Eco57I,Methyltransf_31,TaqI_C k59_934726_1 1238450.VIBNISOn1_830107 4.8e-17 85.1 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XT0M@135623|Vibrionales 135623|Vibrionales M protein conserved in bacteria - - - ko:K16291,ko:K19236 ko01503,map01503 - - - ko00000,ko00001,ko01002,ko01011 - - - LysM,YkuD k59_312326_1 1121405.dsmv_0430 1.9e-80 247.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MJ0G@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_84260_2 204669.Acid345_4094 1.08e-05 47.0 COG1834@1|root,COG1834@2|Bacteria,3Y86C@57723|Acidobacteria 57723|Acidobacteria E Amidinotransferase - - 3.5.3.18 ko:K01482 - - - - ko00000,ko01000,ko04147 - - - Amidinotransf k59_640653_1 1219080.VEZ01S_27_00010 2.32e-07 60.5 COG2911@1|root,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,1Y3D5@135623|Vibrionales 135623|Vibrionales S Bacterial Ig-like domain (group 3) - - - - - - - - - - - - Big_3_2 k59_901506_1 1410609.JHVB01000001_gene1835 2.31e-74 249.0 COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes 203691|Spirochaetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_608056_1 118173.KB235910_gene4728 1.7e-22 100.0 COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,1H71F@1150|Oscillatoriales 1117|Cyanobacteria O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_736951_1 395019.Bmul_1485 4.74e-25 99.4 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,1K2WG@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family phbB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_967074_1 67352.JODS01000003_gene2174 3.82e-72 227.0 COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria 201174|Actinobacteria E HAD-superfamily subfamily IB hydrolase, TIGR01490 serB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - HAD k59_836114_2 396588.Tgr7_3307 5.17e-53 181.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1WVYR@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_575109_1 332101.JIBU02000013_gene1362 5.47e-26 115.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae 186801|Clostridia C NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_836116_2 749222.Nitsa_0515 2.43e-43 148.0 COG4314@1|root,COG4314@2|Bacteria,1N43A@1224|Proteobacteria,42U7U@68525|delta/epsilon subdivisions,2YN6A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NosL - - - - - - - - - - - - NosL k59_1000104_1 472759.Nhal_3915 9.24e-26 96.7 COG1598@1|root,COG1598@2|Bacteria,1P4UT@1224|Proteobacteria 1224|Proteobacteria S PFAM Uncharacterised protein family UPF0150 - - - - - - - - - - - - - k59_156471_1 869213.JCM21142_93741 1.82e-89 290.0 COG3250@1|root,COG3250@2|Bacteria,4NEP8@976|Bacteroidetes,47P44@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_156471_2 1121097.JCM15093_1645 3.64e-44 160.0 COG3250@1|root,COG4225@1|root,COG3250@2|Bacteria,COG4225@2|Bacteria,4NESZ@976|Bacteroidetes,2FPDW@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_516589_1 765913.ThidrDRAFT_0398 8.05e-72 226.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1WWNS@135613|Chromatiales 135613|Chromatiales I TIGRFAM malonyl CoA-acyl carrier protein transacylase - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_516589_2 1101195.Meth11DRAFT_1225 8.32e-06 47.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,2KMAU@206350|Nitrosomonadales 206350|Nitrosomonadales IQ TIGRFAM 3-oxoacyl-(acyl-carrier-protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_384157_1 926560.KE387025_gene4059 3.61e-28 112.0 2DBAF@1|root,2Z82V@2|Bacteria,1WJNY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L CRISPR-associated protein (Cas_Cas5) - - - ko:K19119 - - - - ko00000,ko02048 - - - Cas_Cas5d k59_646176_1 911239.CF149_17315 7.36e-52 169.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the WrbA family wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_646176_2 395493.BegalDRAFT_2716 1.24e-25 103.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,4611E@72273|Thiotrichales 72273|Thiotrichales L Belongs to the DnaA family. HdA subfamily - - - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_1005450_1 1255043.TVNIR_2414 2.12e-43 156.0 COG0709@1|root,COG1252@1|root,COG0709@2|Bacteria,COG1252@2|Bacteria,1MWFG@1224|Proteobacteria,1RQ5Q@1236|Gammaproteobacteria,1X13W@135613|Chromatiales 135613|Chromatiales CE AIR synthase related protein, N-terminal domain - - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C,Pyr_redox_2 k59_1005450_2 69395.JQLZ01000002_gene1005 1.74e-09 59.3 COG1262@1|root,COG4301@1|root,COG1262@2|Bacteria,COG4301@2|Bacteria,1MUNC@1224|Proteobacteria,2TQXE@28211|Alphaproteobacteria,2KFXT@204458|Caulobacterales 204458|Caulobacterales S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase,Methyltransf_33 k59_580312_1 1278073.MYSTI_03700 1.44e-05 47.4 COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - DUF11,OmpA,Phenol_MetA_deg,TSP_3 k59_710990_2 1121859.KB890756_gene1429 7.98e-77 257.0 COG1629@1|root,COG1629@2|Bacteria,4PN6G@976|Bacteroidetes 976|Bacteroidetes P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug k59_317525_1 411490.ANACAC_00429 2.61e-48 165.0 COG0673@1|root,COG0673@2|Bacteria,1UZEK@1239|Firmicutes,24AR9@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_317525_4 1158610.UC3_03243 3.61e-19 87.8 COG0673@1|root,COG0673@2|Bacteria,1UZEK@1239|Firmicutes,4HUSS@91061|Bacilli 91061|Bacilli S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_317525_5 697281.Mahau_1217 2.66e-21 99.0 COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,1VDX5@1239|Firmicutes,25F4T@186801|Clostridia,42HXP@68295|Thermoanaerobacterales 186801|Clostridia K PFAM helix-turn-helix- domain containing protein, AraC type - - - ko:K02855 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18 k59_317525_6 748449.Halha_1741 0.0 882.0 COG1070@1|root,COG1070@2|Bacteria,1TP91@1239|Firmicutes,24A4Z@186801|Clostridia 186801|Clostridia G Carbohydrate kinase, FGGY family protein araB - - - - - - - - - - - FGGY_C,FGGY_N k59_317525_7 1122918.KB907250_gene3620 4.25e-171 491.0 COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,4HBDM@91061|Bacilli,26T54@186822|Paenibacillaceae 91061|Bacilli G Belongs to the binding-protein-dependent transport system permease family araH - - ko:K10544,ko:K10547 ko02010,map02010 M00215,M00216 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.4,3.A.1.2.5 - - BPD_transp_2 k59_1005451_1 1168034.FH5T_09960 2.92e-56 187.0 COG0165@1|root,COG0165@2|Bacteria,4NFCY@976|Bacteroidetes,2FPNB@200643|Bacteroidia 976|Bacteroidetes E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Lyase_1 k59_939998_1 768671.ThimaDRAFT_0575 1.08e-99 304.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPN9@1236|Gammaproteobacteria,1WWMD@135613|Chromatiales 135613|Chromatiales S of ABC transporters with duplicated ATPase - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_89972_1 2340.JV46_17100 1.39e-54 189.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1J4W4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1038246_1 545276.KB898729_gene1647 1.43e-98 290.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1WVVY@135613|Chromatiales 135613|Chromatiales E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_647181_1 1165841.SULAR_10329 5.09e-72 218.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,42RDZ@68525|delta/epsilon subdivisions,2YP5I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_647181_2 387093.SUN_0141 9.37e-68 225.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2YMUW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_56021_1 519989.ECTPHS_01634 8.01e-101 310.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_941108_1 1249480.B649_10965 1.22e-19 87.4 COG0778@1|root,COG0778@2|Bacteria,1N95W@1224|Proteobacteria,42T85@68525|delta/epsilon subdivisions,2YPNS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_842214_1 1121405.dsmv_3251 5.94e-71 236.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MHZG@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_91113_4 326298.Suden_0481 1.39e-94 290.0 COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,42M6F@68525|delta/epsilon subdivisions,2YMXE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase, class I patB - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_711885_2 1288494.EBAPG3_26350 1.38e-58 197.0 COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,2VPEA@28216|Betaproteobacteria,3729T@32003|Nitrosomonadales 28216|Betaproteobacteria O pdz dhr glgf - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_20238_1 1144319.PMI16_01881 1.2e-59 229.0 COG3209@1|root,COG3209@2|Bacteria,1R1SB@1224|Proteobacteria,2W3D6@28216|Betaproteobacteria 1224|Proteobacteria M Salmonella virulence plasmid 65kDa B protein - - - - - - - - - - - - VCBS k59_222233_1 1049564.TevJSym_ac00480 2.9e-49 170.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4I6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_222233_2 697282.Mettu_3285 5.15e-28 103.0 COG0724@1|root,COG0724@2|Bacteria,1NDEM@1224|Proteobacteria,1SFDX@1236|Gammaproteobacteria,1XFGC@135618|Methylococcales 135618|Methylococcales S PFAM RNA recognition motif - - - - - - - - - - - - RRM_1 k59_874703_1 1454007.JAUG01000029_gene3184 1.2e-11 64.7 COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,1IP9D@117747|Sphingobacteriia 976|Bacteroidetes G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos k59_874703_2 36874.HQ34_04270 7.79e-20 92.4 COG1074@1|root,COG1074@2|Bacteria,4NEX4@976|Bacteroidetes,2FMHG@200643|Bacteroidia,22W5V@171551|Porphyromonadaceae 976|Bacteroidetes L Belongs to the helicase family. UvrD subfamily addA - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_450035_1 1400520.LFAB_16145 0.000442 42.0 COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,4HCJE@91061|Bacilli,3F5GY@33958|Lactobacillaceae 91061|Bacilli M RmlD substrate binding domain cps2D - 5.1.3.2,5.1.3.25 ko:K01784,ko:K17947 ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130 M00361,M00362,M00632 R00291,R02984,R10279 RC00289 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS00780 Epimerase,GDP_Man_Dehyd k59_353431_1 1158146.KB907121_gene913 6.27e-36 132.0 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1WWKK@135613|Chromatiales 135613|Chromatiales O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_647201_1 640511.BC1002_4873 1.77e-05 51.6 COG5607@1|root,COG5607@2|Bacteria,1QTX6@1224|Proteobacteria,2W1SX@28216|Betaproteobacteria,1KG3V@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM CHAD domain containing protein - - - - - - - - - - - - CHAD k59_647201_2 1380393.JHVP01000003_gene1214 1.73e-14 71.2 COG1192@1|root,COG1192@2|Bacteria,2IGYZ@201174|Actinobacteria 201174|Actinobacteria D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 k59_91128_1 95619.PM1_0228605 1.88e-64 206.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_353432_1 639282.DEFDS_1418 3.76e-93 283.0 COG0136@1|root,COG0136@2|Bacteria,2GF4J@200930|Deferribacteres 200930|Deferribacteres E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_711891_2 153721.MYP_525 8e-14 79.7 COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,47JUP@768503|Cytophagia 976|Bacteroidetes S PFAM von Willebrand factor type A batA - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_711891_3 1049564.TevJSym_bh00110 4.73e-20 88.6 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1J577@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_777055_1 1122137.AQXF01000005_gene1305 1.8e-22 95.9 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,2VF2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_416936_1 688269.Theth_0083 1.92e-08 58.2 COG1555@1|root,COG1555@2|Bacteria,2GD8U@200918|Thermotogae 200918|Thermotogae L TIGRFAM competence protein ComEA helix-hairpin-helix repeat - - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 k59_517690_1 1168034.FH5T_16650 5.4e-97 289.0 COG1051@1|root,COG1051@2|Bacteria,4NIBP@976|Bacteroidetes,2FNT4@200643|Bacteroidia 976|Bacteroidetes F Hydrolase, NUDIX family - - - - - - - - - - - - NUDIX k59_517690_2 1168034.FH5T_16655 8.67e-61 196.0 COG0012@1|root,COG0012@2|Bacteria,4NF7N@976|Bacteroidetes,2FMWX@200643|Bacteroidia 976|Bacteroidetes J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_941136_1 1223410.KN050846_gene791 5.84e-114 338.0 COG1322@1|root,COG1322@2|Bacteria,4NE04@976|Bacteroidetes,1HYTA@117743|Flavobacteriia 976|Bacteroidetes S protein conserved in bacteria rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_743076_2 1038869.AXAN01000031_gene517 2.38e-18 82.0 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,2VVP0@28216|Betaproteobacteria,1K760@119060|Burkholderiaceae 28216|Betaproteobacteria J RNA-binding protein yhbY - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_743076_3 713586.KB900536_gene3038 3.6e-87 262.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1WX98@135613|Chromatiales 135613|Chromatiales J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_874725_1 1121085.AUCI01000002_gene3875 0.00043 48.5 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1ZAVY@1386|Bacillus 91061|Bacilli T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_4 k59_123858_1 1168034.FH5T_06195 2.38e-145 431.0 COG0642@1|root,COG2205@2|Bacteria,4NEFW@976|Bacteroidetes,2FSEE@200643|Bacteroidia 976|Bacteroidetes T His Kinase A (phosphoacceptor) domain rprX - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_680278_1 391615.ABSJ01000029_gene1955 4.08e-64 207.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1J4BT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_517697_1 1168034.FH5T_11980 3.3e-86 274.0 COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes 976|Bacteroidetes C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_20272_1 523791.Kkor_0378 8.67e-54 181.0 COG1878@1|root,COG1878@2|Bacteria 2|Bacteria S arylformamidase activity - - - - - - - - - - - - Cyclase k59_647216_1 395493.BegalDRAFT_2990 8.7e-45 159.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,45ZXR@72273|Thiotrichales 72273|Thiotrichales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_647216_2 1144319.PMI16_03320 1.75e-10 62.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,473X2@75682|Oxalobacteraceae 28216|Betaproteobacteria K Crp Fnr family transcription regulator anr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_450067_1 1410670.JHXF01000017_gene1916 2.96e-09 64.3 COG1705@1|root,COG1705@2|Bacteria,1UMKN@1239|Firmicutes,25GKA@186801|Clostridia 186801|Clostridia NU CotH kinase protein - - - - - - - - - - - - CotH k59_941152_1 4113.PGSC0003DMT400018310 3.36e-07 57.0 COG3320@1|root,KOG1221@2759|Eukaryota,37IRY@33090|Viridiplantae,3G7T7@35493|Streptophyta,44NB1@71274|asterids 35493|Streptophyta I Catalyzes the reduction of fatty acyl-CoA to fatty alcohols - - 1.2.1.84 ko:K13356 ko00073,ko04146,ko04212,map00073,map04146,map04212 - R09470 RC00004 ko00000,ko00001,ko01000 - - - NAD_binding_4,Sterile k59_254070_1 522306.CAP2UW1_2630 7.16e-19 83.6 2CNUX@1|root,32SHU@2|Bacteria,1REYT@1224|Proteobacteria,2VR2A@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF2760) - - - - - - - - - - - - DUF2760 k59_874748_1 686340.Metal_0558 1.5e-52 170.0 COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,1S337@1236|Gammaproteobacteria,1XG7T@135618|Methylococcales 135618|Methylococcales C Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity azoR - - - - - - - - - - - Flavodoxin_2 k59_874748_2 1283300.ATXB01000001_gene1724 1.26e-19 82.8 COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,1S8UI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane yqjF - - ko:K15977 - - - - ko00000 - - - DoxX k59_482027_1 749222.Nitsa_2111 5.4e-218 615.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2YMDG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD k59_482027_2 679897.HMU07850 7.28e-18 80.5 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2YNX4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_614486_1 28072.Nos7524_1286 3.75e-22 101.0 COG2931@1|root,COG3210@1|root,COG3291@1|root,COG3595@1|root,COG4070@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria,1GHDQ@1117|Cyanobacteria,1HUA0@1161|Nostocales 1117|Cyanobacteria Q Domain of unknown function (DUF4114) - - - - - - - - - - - - DUF4114 k59_1038324_1 1168065.DOK_05245 2.87e-113 335.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1J946@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_973132_1 760154.Sulba_2364 1.4e-57 188.0 COG2378@1|root,COG2378@2|Bacteria,1R65H@1224|Proteobacteria,42PYW@68525|delta/epsilon subdivisions,2YN39@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_11,WYL k59_123887_1 999541.bgla_1g07870 3.85e-61 196.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2VHA6@28216|Betaproteobacteria,1JZPM@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_123887_2 561230.PC1_4006 9.63e-34 125.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,1MRUJ@122277|Pectobacterium 1236|Gammaproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rffG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_3926,iECSF_1327.ECSF_3628 GDP_Man_Dehyd k59_680300_1 96561.Dole_2694 7.43e-25 102.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2MHKY@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_680300_2 1056820.KB900674_gene2534 1.41e-14 74.3 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,2PN36@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Found in ATP-dependent protease La (LON) lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_614493_1 83406.HDN1F_29060 1.01e-154 452.0 COG0286@1|root,COG0286@2|Bacteria,1MXPV@1224|Proteobacteria,1RXYG@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Type I restriction-modification system methyltransferase subunit - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HSDR_N_2,Methylase_S,N6_Mtase k59_549413_1 2340.JV46_26150 2.76e-87 260.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1J4YR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH COG0512 Anthranilate para-aminobenzoate synthases component II pabA GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135 GATase k59_293007_3 592029.DDD_0888 3.34e-46 154.0 COG4675@1|root,COG4675@2|Bacteria,4NQJR@976|Bacteroidetes,1I31T@117743|Flavobacteriia 976|Bacteroidetes S PFAM phage Tail Collar domain - - - - - - - - - - - - Collar k59_489472_1 471857.Svir_00480 0.000124 49.3 COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4DYEU@85010|Pseudonocardiales 201174|Actinobacteria G Belongs to the HpcH HpaI aldolase family mcl2 - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI,PEP-utilizers_C k59_882070_1 1168034.FH5T_06910 1.83e-119 354.0 COG0055@1|root,COG0055@2|Bacteria,4NF1Q@976|Bacteroidetes,2FP0J@200643|Bacteroidia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_814417_1 565045.NOR51B_2323 2.68e-110 326.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1J4KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein, pilus retraction ATPase PilT pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_882077_1 1049564.TevJSym_aa01930 2.59e-113 360.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_489495_1 357276.EL88_10880 1.4e-60 199.0 COG1621@1|root,COG1621@2|Bacteria,4NGJC@976|Bacteroidetes,2FP75@200643|Bacteroidia,4AW2K@815|Bacteroidaceae 976|Bacteroidetes G beta-fructofuranosidase activity - - - - - - - - - - - - - k59_814424_1 1256908.HMPREF0373_01022 3.99e-32 125.0 COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,25V8G@186806|Eubacteriaceae 186801|Clostridia F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_814437_1 367737.Abu_1882 1.61e-09 58.9 2AJ4J@1|root,319P3@2|Bacteria,1Q3DP@1224|Proteobacteria,42X5G@68525|delta/epsilon subdivisions,2YQYN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_849453_1 1122604.JONR01000004_gene889 1.4e-89 292.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5MD@135614|Xanthomonadales 135614|Xanthomonadales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_325896_1 1121396.KB893051_gene3445 4.48e-59 195.0 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MI9D@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 k59_814444_1 537013.CLOSTMETH_01557 0.000128 48.9 COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,24AE1@186801|Clostridia,3WJ7R@541000|Ruminococcaceae 186801|Clostridia E Vitamin B12 dependent methionine synthase activation metH2 - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Met_synt_B12 k59_882107_1 396588.Tgr7_3061 1.53e-64 208.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales 135613|Chromatiales C PFAM Alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_882107_2 930166.CD58_06620 5.99e-15 71.6 COG3133@1|root,COG3133@2|Bacteria,1RJXC@1224|Proteobacteria,1SYAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria M membrane IV02_08655 - - ko:K06077 - - - - ko00000 - - - Rick_17kDa_Anti k59_750848_1 1049564.TevJSym_aq00110 5.44e-63 213.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1J4DP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f k59_424571_1 203124.Tery_3489 1.82e-29 121.0 COG2831@1|root,COG3210@1|root,COG2831@2|Bacteria,COG3210@2|Bacteria,1G0EK@1117|Cyanobacteria,1H6WE@1150|Oscillatoriales 1117|Cyanobacteria U filamentous hemagglutinin family N-terminal domain - - - - - - - - - - - - Haemagg_act,POTRA_2,ShlB k59_882139_1 1168034.FH5T_17790 1.08e-61 203.0 COG0673@1|root,COG0673@2|Bacteria,4NGPP@976|Bacteroidetes,2FW0T@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,TAT_signal k59_849498_1 80884.CCF32369 1.19e-39 144.0 COG1028@1|root,KOG1209@2759|Eukaryota,3AERP@33154|Opisthokonta,3PCAD@4751|Fungi,3R1E6@4890|Ascomycota,21NQJ@147550|Sordariomycetes,1EUWI@1028384|Glomerellales 4751|Fungi Q Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_293124_1 84531.JMTZ01000038_gene3596 3.24e-39 149.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales 135614|Xanthomonadales E glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_325946_1 313603.FB2170_06625 2.94e-180 524.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,1HZAM@117743|Flavobacteriia,2PIWJ@252356|Maribacter 976|Bacteroidetes G Glycosyl hydrolase family 92 - - - - - - - - - - - - Glyco_hydro_92 k59_489559_2 314275.MADE_1009000 7.43e-91 288.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,1RNC7@1236|Gammaproteobacteria,465DW@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG3634 Alkyl hydroperoxide reductase, large subunit ahpF GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008785,GO:0009321,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204 - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_489559_3 526218.Sterm_0377 7.62e-118 344.0 COG0708@1|root,COG0708@2|Bacteria,378ZF@32066|Fusobacteria 32066|Fusobacteria L Endonuclease/Exonuclease/phosphatase family xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_489559_5 1262449.CP6013_3057 7.66e-73 228.0 COG1346@1|root,COG1346@2|Bacteria,1TRGN@1239|Firmicutes,24AGM@186801|Clostridia,36HZR@31979|Clostridiaceae 186801|Clostridia M PFAM LrgB family protein lrgB - - - - - - - - - - - LrgB k59_489559_6 469617.FUAG_00450 9.69e-29 107.0 COG1380@1|root,COG1380@2|Bacteria,37AAP@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score - - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA k59_489559_7 1293054.HSACCH_02530 1.31e-32 121.0 COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia,3WAUZ@53433|Halanaerobiales 186801|Clostridia CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,DsbD,Redoxin k59_489559_8 1307761.L21SP2_1116 1.75e-26 111.0 COG0785@1|root,COG0785@2|Bacteria,2J640@203691|Spirochaetes 203691|Spirochaetes O cytochrome c biogenesis protein - - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_489559_9 519441.Smon_1004 6.84e-116 353.0 COG0446@1|root,COG0446@2|Bacteria,3793H@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 9.26 - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_882163_1 1215092.PA6_020_01200 1.56e-08 58.2 2DR2Y@1|root,339YA@2|Bacteria,1NHB7@1224|Proteobacteria,1SDH6@1236|Gammaproteobacteria,1YKTT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_63971_1 743718.Isova_1640 3.77e-91 281.0 COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4F3PX@85017|Promicromonosporaceae 201174|Actinobacteria J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_489577_1 1009370.ALO_08525 1.3e-71 238.0 COG2185@1|root,COG2185@2|Bacteria,1V45Q@1239|Firmicutes,4H4DH@909932|Negativicutes 909932|Negativicutes I B12 binding domain - - 5.4.99.1 ko:K01846 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R00262 RC01221 ko00000,ko00001,ko00002,ko01000 - - - B12-binding k59_882168_1 1168034.FH5T_08685 2.03e-16 77.8 COG0215@1|root,COG0215@2|Bacteria,4NE3Y@976|Bacteroidetes,2FM9D@200643|Bacteroidia 976|Bacteroidetes J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_882168_2 1168034.FH5T_08690 7.53e-108 313.0 COG0307@1|root,COG0307@2|Bacteria,4NHI8@976|Bacteroidetes,2FNEF@200643|Bacteroidia 976|Bacteroidetes H Riboflavin synthase ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_849521_2 324602.Caur_1618 2.96e-15 76.6 COG2890@1|root,COG2890@2|Bacteria,2G6I8@200795|Chloroflexi,375AV@32061|Chloroflexia 32061|Chloroflexia J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS k59_293144_1 941449.dsx2_1445 3.77e-15 76.6 COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,42QQ7@68525|delta/epsilon subdivisions,2WN8Z@28221|Deltaproteobacteria,2M8UD@213115|Desulfovibrionales 28221|Deltaproteobacteria M Linear amide C-N hydrolases, choloylglycine hydrolase family - - 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 - R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CBAH k59_28124_1 572477.Alvin_0639 3.43e-85 276.0 COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1WX8Z@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K02482,ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,MASE1,PAS_4,PAS_9 k59_325954_2 1232437.KL662020_gene705 9.56e-198 564.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_28126_1 399742.Ent638_1562 3e-36 139.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes clsC GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0090483,GO:1901576 - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_750916_1 316274.Haur_2045 5.5e-59 202.0 COG3328@1|root,COG3328@2|Bacteria,2G6SX@200795|Chloroflexi 200795|Chloroflexi L PFAM transposase mutator type - - - - - - - - - - - - Transposase_mut k59_28132_1 387093.SUN_0682 3.52e-25 97.4 COG2010@1|root,COG2010@2|Bacteria,1QA9H@1224|Proteobacteria,42VAH@68525|delta/epsilon subdivisions,2YQGU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_28132_2 387093.SUN_0681 1.49e-28 112.0 COG5002@1|root,COG5002@2|Bacteria,1QZ29@1224|Proteobacteria,43CEG@68525|delta/epsilon subdivisions,2YTC2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_424633_1 941824.TCEL_01450 9.01e-115 343.0 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1TP5X@1239|Firmicutes,247WT@186801|Clostridia,36DI9@31979|Clostridiaceae 186801|Clostridia G Pts system - - 2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02809,ko:K02810 ko00500,ko02060,map00500,map02060 M00269,M00271 R00811 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6,4.A.1.2.9 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_424633_4 1408437.JNJN01000026_gene701 1.52e-57 183.0 COG4702@1|root,COG4702@2|Bacteria,1VBQP@1239|Firmicutes,24PFD@186801|Clostridia 186801|Clostridia S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_293166_1 177437.HRM2_09390 3.92e-66 219.0 COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria,433HE@68525|delta/epsilon subdivisions,2WYHG@28221|Deltaproteobacteria,2MP7M@213118|Desulfobacterales 28221|Deltaproteobacteria L Domain of unknown function (DUF4277) - - - - - - - - - - - - DUF4277 k59_814542_1 278957.ABEA03000149_gene4064 1.58e-67 219.0 COG0439@1|root,COG0439@2|Bacteria,46SIE@74201|Verrucomicrobia,3K78R@414999|Opitutae 414999|Opitutae I acetyl-CoA carboxylase - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_293173_1 435908.IDSA_01670 1.48e-08 62.4 COG1073@1|root,COG1073@2|Bacteria,1NVTC@1224|Proteobacteria,1RNXQ@1236|Gammaproteobacteria,2QFGB@267893|Idiomarinaceae 1236|Gammaproteobacteria S Bacterial virulence factor lipase N-terminal - - - - - - - - - - - - Lipase_bact_N k59_814544_2 1192034.CAP_3201 1.11e-44 164.0 COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2YYK8@29|Myxococcales 28221|Deltaproteobacteria IQ PKS_DH - - - ko:K15314 ko01059,ko01130,map01059,map01130 M00824,M00825 R11435 - ko00000,ko00001,ko00002,ko01008 - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_28186_1 580332.Slit_0264 8.9e-05 48.9 2AFYG@1|root,31628@2|Bacteria,1PWQT@1224|Proteobacteria,2WC9D@28216|Betaproteobacteria,44VMT@713636|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_750977_1 264201.pc1492 1.4e-05 52.4 COG3039@1|root,COG3039@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1_3 k59_64031_1 1168034.FH5T_01780 3.96e-97 301.0 COG0561@1|root,COG0561@2|Bacteria,4PKHD@976|Bacteroidetes,2G0K6@200643|Bacteroidia 976|Bacteroidetes S Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_882238_1 580332.Slit_0350 6.54e-13 68.9 COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,2VJR3@28216|Betaproteobacteria,44W7Z@713636|Nitrosomonadales 28216|Betaproteobacteria IQ Beta-ketoacyl synthase, C-terminal domain fabB - 2.3.1.179,2.3.1.41 ko:K00647,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_882238_2 1123504.JQKD01000035_gene2695 1.35e-59 194.0 COG0304@1|root,COG0304@2|Bacteria,1NP8M@1224|Proteobacteria,2VJDN@28216|Betaproteobacteria,4ADNR@80864|Comamonadaceae 28216|Betaproteobacteria IQ Beta-ketoacyl synthase, N-terminal domain - - - - - - - - - - - - Ketoacyl-synt_2 k59_196864_2 479435.Kfla_2889 8.59e-78 253.0 COG0206@1|root,COG3266@1|root,COG0206@2|Bacteria,COG3266@2|Bacteria,2GJWC@201174|Actinobacteria,4DND0@85009|Propionibacteriales 201174|Actinobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_589246_3 1122194.AUHU01000017_gene1775 2.82e-22 93.2 COG3201@1|root,COG3201@2|Bacteria,1MXN4@1224|Proteobacteria,1RMZE@1236|Gammaproteobacteria,467GF@72275|Alteromonadaceae 1236|Gammaproteobacteria H nicotinamide mononucleotide transporter pnuC - - ko:K03811 - - - - ko00000,ko02000 4.B.1.1 - - NMN_transporter k59_66123_1 1249627.D779_4189 9.1e-103 331.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1141@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1141@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales 135613|Chromatiales C pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_33486_1 754476.Q7A_2463 1.28e-59 194.0 COG0515@1|root,COG0515@2|Bacteria,1MXX9@1224|Proteobacteria,1RQFJ@1236|Gammaproteobacteria,4629K@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core - - - ko:K02848 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005 - - - Kdo k59_752653_1 1319815.HMPREF0202_02282 1.07e-50 179.0 COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,379E9@32066|Fusobacteria 32066|Fusobacteria C belongs to the iron- containing alcohol dehydrogenase family - - 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 - R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 - - - Aldedh,Fe-ADH k59_752653_2 401526.TcarDRAFT_0411 5.68e-17 75.9 COG1905@1|root,COG1905@2|Bacteria,1VFEK@1239|Firmicutes,4H5UM@909932|Negativicutes 909932|Negativicutes C Thioredoxin-like [2Fe-2S] ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx k59_752653_3 118163.Ple7327_2687 2.74e-41 143.0 COG3829@1|root,COG3829@2|Bacteria,1GQTX@1117|Cyanobacteria 1117|Cyanobacteria KT PAS domain - - - - - - - - - - - - PAS_9 k59_752653_4 1173028.ANKO01000017_gene236 2.83e-104 320.0 COG2208@1|root,COG2208@2|Bacteria,1G1FC@1117|Cyanobacteria,1H81M@1150|Oscillatoriales 1117|Cyanobacteria KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - SpoIIE k59_752653_5 552811.Dehly_0625 4.23e-10 59.7 COG1905@1|root,COG1905@2|Bacteria,2G6Q5@200795|Chloroflexi,34CUJ@301297|Dehalococcoidia 301297|Dehalococcoidia C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_752653_6 572544.Ilyop_1421 6.6e-154 452.0 COG1142@1|root,COG1146@1|root,COG4624@1|root,COG1142@2|Bacteria,COG1146@2|Bacteria,COG4624@2|Bacteria,37BPA@32066|Fusobacteria 32066|Fusobacteria C PFAM hydrogenase large subunit domain protein - - - - - - - - - - - - Fe_hyd_lg_C,Fer4 k59_425659_1 1168034.FH5T_03085 1.76e-64 202.0 COG4191@1|root,COG4191@2|Bacteria,4NQBN@976|Bacteroidetes,2FTEN@200643|Bacteroidia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c k59_556488_1 1234364.AMSF01000016_gene1547 1.56e-58 198.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1X3VI@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the DNA photolyase family phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_327758_1 1167006.UWK_01625 7.08e-13 68.9 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WMIQ@28221|Deltaproteobacteria,2MJ5G@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM HDOD domain - - - - - - - - - - - - HDOD k59_262254_1 1517416.IDAT_02680 4.89e-24 106.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2QFRV@267893|Idiomarinaceae 1236|Gammaproteobacteria U Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_393113_1 1168034.FH5T_01455 1.18e-106 314.0 COG1773@1|root,COG1853@1|root,COG1773@2|Bacteria,COG1853@2|Bacteria,4NHF0@976|Bacteroidetes,2FUN6@200643|Bacteroidia 976|Bacteroidetes C rubredoxin rubR - - - - - - - - - - - Rubredoxin k59_393113_2 344747.PM8797T_26465 1.02e-19 90.1 COG2706@1|root,COG2706@2|Bacteria,2IY02@203682|Planctomycetes 203682|Planctomycetes G COG2706 3-carboxymuconate cyclase - - 3.1.1.31 ko:K07404 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Lactonase k59_850691_2 1265505.ATUG01000001_gene3492 1.14e-46 170.0 COG0784@1|root,COG2202@1|root,COG4191@1|root,COG4936@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHWA@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,Response_reg k59_164290_1 1122201.AUAZ01000038_gene1158 1.12e-117 350.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,464ET@72275|Alteromonadaceae 1236|Gammaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iJN746.PP_4678,iLF82_1304.LF82_1103 IlvC,IlvN k59_948715_1 118005.AWNK01000003_gene2230 1.18e-81 265.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria 2|Bacteria G chondroitin AC lyase activity ndvB - 2.4.1.12,3.2.1.58 ko:K00694,ko:K01210,ko:K03292 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R00308,R02889,R03115 RC00005,RC00467 ko00000,ko00001,ko01000,ko01003,ko02000 2.A.2,4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,MFS_2 k59_600_1 161934.XP_010686370.1 8.56e-11 62.0 COG0076@1|root,KOG0628@2759|Eukaryota,37T28@33090|Viridiplantae,3GFW2@35493|Streptophyta 35493|Streptophyta E Aromatic-L-amino-acid decarboxylase - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC k59_600_2 1054213.HMPREF9946_00422 1.81e-14 69.7 COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,2JTTR@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the acylphosphatase family acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_600_3 1168034.FH5T_14775 9.17e-43 143.0 2EFWM@1|root,339NX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_262261_1 1168034.FH5T_10755 1.19e-94 303.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,4NE1X@976|Bacteroidetes,2FMPX@200643|Bacteroidia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_327771_1 670292.JH26_08910 1.9e-20 91.3 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,1JVDT@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_327771_2 1268237.G114_07032 1.99e-14 69.7 COG2963@1|root,COG2963@2|Bacteria,1NBFZ@1224|Proteobacteria,1SFDA@1236|Gammaproteobacteria,1Y65R@135624|Aeromonadales 135624|Aeromonadales L COG2963 Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_719949_2 1385517.N800_13135 1.02e-54 176.0 2B4XH@1|root,32REP@2|Bacteria,1RJ9F@1224|Proteobacteria,1T0SV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_626158_1 314278.NB231_13121 4.14e-37 130.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1WY75@135613|Chromatiales 135613|Chromatiales H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis - - 1.5.1.3 ko:K00287,ko:K18590 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 br01600,ko00000,ko00001,ko00002,ko01000,ko01504 - - - DHFR_1 k59_463368_1 2340.JV46_19210 2.07e-75 247.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1J4VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08483,ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_298885_1 997296.PB1_09347 9.3e-22 91.3 COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,4H9Z2@91061|Bacilli,1ZCAE@1386|Bacillus 91061|Bacilli D cell division ATP-binding protein FtsE ftsE GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0008356,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0032506,GO:0042173,GO:0043937,GO:0043938,GO:0044085,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:1902531 - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_298885_2 642492.Clole_3496 7.25e-28 117.0 COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia 186801|Clostridia D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_887065_1 518766.Rmar_0342 3.44e-32 127.0 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1FJVJ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrd - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_887065_2 1453501.JELR01000001_gene2482 1.24e-09 56.2 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SD3Y@1236|Gammaproteobacteria,468XD@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_201012_1 572544.Ilyop_0694 8.7e-107 332.0 COG0058@1|root,COG0058@2|Bacteria,378HK@32066|Fusobacteria 32066|Fusobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_920820_1 1168034.FH5T_13650 2.2e-74 231.0 COG1562@1|root,COG1562@2|Bacteria,4NEIK@976|Bacteroidetes,2FS8N@200643|Bacteroidia 976|Bacteroidetes I Squalene/phytoene synthase crtB - - - - - - - - - - - SQS_PSY k59_822457_1 187272.Mlg_0817 2.28e-90 286.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_104191_1 1168034.FH5T_12350 3.42e-61 199.0 COG2235@1|root,COG2235@2|Bacteria,4NHKZ@976|Bacteroidetes,2FRKB@200643|Bacteroidia 976|Bacteroidetes E Amidinotransferase - - 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 - R00552 RC00177 ko00000,ko00001,ko01000 - - - Amidinotransf k59_104191_2 655815.ZPR_3735 2.67e-13 67.0 COG0566@1|root,COG0566@2|Bacteria,4NM8C@976|Bacteroidetes,1HY0Q@117743|Flavobacteriia 976|Bacteroidetes J Methyltransferase spoU - - - - - - - - - - - SpoU_methylase k59_756869_1 1168034.FH5T_17520 5.07e-95 290.0 COG0464@1|root,COG0464@2|Bacteria,4NFWG@976|Bacteroidetes,2FR01@200643|Bacteroidia 976|Bacteroidetes O ATPase, AAA family - - - - - - - - - - - - AAA k59_496178_1 709032.Sulku_1099 1.63e-32 114.0 2AJQW@1|root,31ACT@2|Bacteria,1Q5CJ@1224|Proteobacteria,43111@68525|delta/epsilon subdivisions,2YSC2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_496178_2 387093.SUN_0742 1.76e-33 119.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,42UF8@68525|delta/epsilon subdivisions,2YPGM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J chain release factor - - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_593609_1 1123070.KB899258_gene1876 4.36e-61 199.0 COG0438@1|root,COG0438@2|Bacteria,46VHB@74201|Verrucomicrobia,2IVB9@203494|Verrucomicrobiae 203494|Verrucomicrobiae M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_529210_1 762903.Pedsa_3010 1.95e-09 58.2 COG2268@1|root,COG2268@2|Bacteria,4NIH3@976|Bacteroidetes,1IUM7@117747|Sphingobacteriia 976|Bacteroidetes S prohibitin homologues yqiK - - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot k59_529210_2 357809.Cphy_1143 4.48e-27 107.0 29F7N@1|root,3025B@2|Bacteria,1V7G9@1239|Firmicutes,24KI2@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - NfeD k59_724596_1 2340.JV46_17540 8.49e-100 304.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1J70K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Dimerisation domain of Zinc Transporter fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_429949_2 1255043.TVNIR_1645 3.01e-52 170.0 COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,1S620@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG1522 Transcriptional regulators nirL - - - - - - - - - - - HTH_AsnC-type k59_692101_1 1168034.FH5T_06750 2.38e-22 93.2 2EBX7@1|root,335WI@2|Bacteria,4NV52@976|Bacteroidetes,2FZ6P@200643|Bacteroidia 976|Bacteroidetes S Putative zincin peptidase - - - - - - - - - - - - DUF3267 k59_659941_1 1121403.AUCV01000014_gene4615 1.74e-19 90.9 COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1R6YN@1224|Proteobacteria,42Q4G@68525|delta/epsilon subdivisions,2WJM9@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - - - - - - - - - - - HDOD,Response_reg k59_626668_2 195253.Syn6312_1045 3.23e-56 181.0 COG0637@1|root,COG0637@2|Bacteria,1G2T2@1117|Cyanobacteria,1GZ2D@1129|Synechococcus 1117|Cyanobacteria S HAD-superfamily hydrolase subfamily IA, variant 3 - - - - - - - - - - - - HAD_2 k59_986168_1 1168034.FH5T_17650 4.73e-131 372.0 COG1595@1|root,COG1595@2|Bacteria,4NVR6@976|Bacteroidetes 976|Bacteroidetes K Sigma-70 region 2 - - - - - - - - - - - - Sigma70_r2 k59_299373_1 1492738.FEM21_13820 7.27e-60 206.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXM6@117743|Flavobacteriia,2NTV9@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_887501_1 525898.Sdel_0185 2.18e-47 160.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2YMG4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - iIT341.HP1375 Acetyltransf_11,Hexapep k59_887501_2 1249480.B649_03525 1.2e-33 125.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2YM9G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_1019094_1 387093.SUN_0823 5.86e-40 137.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,42RPS@68525|delta/epsilon subdivisions,2YP4Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_823024_1 387093.SUN_0140 1.44e-70 229.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,42M47@68525|delta/epsilon subdivisions,2YMRS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T (EAL) domain protein - - - - - - - - - - - - EAL,GGDEF k59_3645_1 1335757.SPICUR_02045 1.38e-68 230.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_3645_2 697282.Mettu_1558 2.11e-11 63.9 COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,1RRYS@1236|Gammaproteobacteria,1XDSY@135618|Methylococcales 135618|Methylococcales P ZIP Zinc transporter - - - - - - - - - - - - - k59_561766_1 465817.ETA_12720 1.54e-23 95.9 COG0231@1|root,COG0231@2|Bacteria,1NWY9@1224|Proteobacteria,1RQ0N@1236|Gammaproteobacteria,3X5WH@551|Erwinia 1236|Gammaproteobacteria J Belongs to the elongation factor P family yeiP GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_561766_2 523791.Kkor_0338 3.6e-52 170.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1XJUJ@135619|Oceanospirillales 135619|Oceanospirillales O Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_429961_1 933262.AXAM01000113_gene2117 2.12e-51 179.0 COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,42M8V@68525|delta/epsilon subdivisions,2WJ7S@28221|Deltaproteobacteria,2MHTW@213118|Desulfobacterales 28221|Deltaproteobacteria F anaerobic ribonucleoside-triphosphate reductase nrdD - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,NRDD k59_429961_2 1304880.JAGB01000001_gene974 6.44e-14 76.3 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia 186801|Clostridia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_299382_1 572477.Alvin_1171 4.85e-21 90.5 COG1142@1|root,COG2878@1|root,COG1142@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales 135613|Chromatiales C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_986189_1 1168034.FH5T_20565 8.83e-88 285.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_397857_1 553184.ATORI0001_0386 2.35e-20 85.5 COG0346@1|root,COG0346@2|Bacteria,2IRBY@201174|Actinobacteria 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase,Glyoxalase_4 k59_626689_1 1232437.KL662000_gene4735 1.79e-82 258.0 COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria,2MHPX@213118|Desulfobacterales 28221|Deltaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity recC - 3.1.11.5 ko:K03583 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_V_gamma k59_529230_1 877455.Metbo_0079 2.07e-134 396.0 COG1896@1|root,arCOG04311@2157|Archaea,2XVI0@28890|Euryarchaeota 28890|Euryarchaeota S HD domain - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_986192_1 1121405.dsmv_3307 9.02e-87 282.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2MIAC@213118|Desulfobacterales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_496208_1 987059.RBXJA2T_12142 1.06e-29 115.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1KJCV@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_496208_2 243233.MCA1366 1.52e-09 61.6 2DRM4@1|root,33C8W@2|Bacteria,1NQ8K@1224|Proteobacteria,1SGVH@1236|Gammaproteobacteria,1XFRG@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_496208_3 545276.KB898725_gene830 1.08e-53 182.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1WZ40@135613|Chromatiales 135613|Chromatiales J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_365408_2 1095750.HMPREF9970_1563 1.45e-150 442.0 COG3395@1|root,COG3395@2|Bacteria,1W75B@1239|Firmicutes,25M8U@186801|Clostridia,1HWE5@1164882|Lachnoanaerobaculum 186801|Clostridia S Putative nucleotide-binding of sugar-metabolising enzyme - - - - - - - - - - - - DUF1357_C,DUF1537 k59_365408_3 1095750.HMPREF9970_1562 2.15e-171 486.0 COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,1HW1Y@1164882|Lachnoanaerobaculum 186801|Clostridia C Pyridoxal phosphate biosynthetic protein PdxA pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_365408_4 1123511.KB905842_gene1677 2.37e-80 250.0 COG1349@1|root,COG1349@2|Bacteria,1UXYW@1239|Firmicutes,4H7RE@909932|Negativicutes 909932|Negativicutes GK DeoR C terminal sensor domain - - - - - - - - - - - - DeoRC,HTH_DeoR k59_887507_2 56780.SYN_03131 5.3e-60 191.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42T3J@68525|delta/epsilon subdivisions,2X5P0@28221|Deltaproteobacteria,2MRWT@213462|Syntrophobacterales 28221|Deltaproteobacteria S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_887507_3 1122927.KB895414_gene5418 7.27e-18 85.5 COG1309@1|root,COG1309@2|Bacteria,1V88I@1239|Firmicutes,4IPKN@91061|Bacilli,26ZE8@186822|Paenibacillaceae 91061|Bacilli K Transcriptional regulator C-terminal region - - - - - - - - - - - - TetR_C_8,TetR_N k59_756907_2 1168034.FH5T_06620 3.9e-33 116.0 COG2921@1|root,COG2921@2|Bacteria,4PBA8@976|Bacteroidetes,2FYR9@200643|Bacteroidia 976|Bacteroidetes S Belongs to the UPF0250 family - - - ko:K09158 - - - - ko00000 - - - DUF493 k59_855639_3 1232447.BAHW02000002_gene45 5.53e-46 167.0 COG1609@1|root,COG1609@2|Bacteria,1TSRM@1239|Firmicutes,24BFS@186801|Clostridia,26CRR@186813|unclassified Clostridiales 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_4 k59_855639_5 929506.CbC4_1945 6.29e-214 610.0 COG4146@1|root,COG4146@2|Bacteria,1UHPR@1239|Firmicutes,24QXT@186801|Clostridia,36FAM@31979|Clostridiaceae 186801|Clostridia S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_429973_1 1168034.FH5T_06760 9.19e-55 176.0 COG0233@1|root,COG0233@2|Bacteria,4NF95@976|Bacteroidetes,2FPZE@200643|Bacteroidia 976|Bacteroidetes J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_429973_2 1168034.FH5T_06750 2.44e-16 77.0 2EBX7@1|root,335WI@2|Bacteria,4NV52@976|Bacteroidetes,2FZ6P@200643|Bacteroidia 976|Bacteroidetes S Putative zincin peptidase - - - - - - - - - - - - DUF3267 k59_823041_1 1231190.NA8A_03105 1.72e-13 70.5 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,43I5X@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Peptidogalycan biosysnthesis/recognition MA20_36195 - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_823041_2 1166948.JPZL01000001_gene2666 2.09e-76 236.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XH86@135619|Oceanospirillales 135619|Oceanospirillales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_1019115_1 1168034.FH5T_05070 5.62e-68 214.0 COG0396@1|root,COG0396@2|Bacteria,4NEMY@976|Bacteroidetes,2FMCD@200643|Bacteroidia 976|Bacteroidetes O FeS assembly ATPase SufC sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_953431_1 387093.SUN_0991 2.68e-109 328.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YMN1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DEAD box helicase family deaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C k59_429977_1 177437.HRM2_18400 7.74e-125 371.0 COG1653@1|root,COG1653@2|Bacteria,1MV8A@1224|Proteobacteria,42N6A@68525|delta/epsilon subdivisions,2WK4K@28221|Deltaproteobacteria,2MIW4@213118|Desulfobacterales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein - - - ko:K17321 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - SBP_bac_1 k59_169830_1 1319815.HMPREF0202_00127 4.58e-81 248.0 COG1175@1|root,COG1175@2|Bacteria,37C9U@32066|Fusobacteria 32066|Fusobacteria U Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_659981_1 1487921.DP68_01000 1.45e-219 632.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,36DUH@31979|Clostridiaceae 186801|Clostridia E Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans k59_234583_1 1430331.EP10_06280 4.04e-29 120.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,1WF4J@129337|Geobacillus 91061|Bacilli KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - CBS,HTH_8,PAS,Sigma54_activat k59_953433_1 1537917.JU82_00790 9.59e-27 105.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2YMR8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_953433_2 563040.Saut_1739 5.58e-107 322.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2YNID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S acid membrane antigen A amaA - - - - - - - - - - - AI-2E_transport k59_823051_1 1121935.AQXX01000143_gene4186 2.78e-71 236.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XHNV@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_397884_1 1049564.TevJSym_ac00340 2.97e-10 58.9 2ER3M@1|root,33IP8@2|Bacteria,1NGAV@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_397884_2 1049564.TevJSym_ac00350 1.09e-36 133.0 2EBH3@1|root,335HM@2|Bacteria,1NDXE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_724637_1 330214.NIDE2825 6.82e-103 320.0 COG2804@1|root,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae 2|Bacteria NU Type II/IV secretion system protein gspE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_692159_1 657309.BXY_41970 2.73e-16 82.4 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FW53@200643|Bacteroidia,4AWE5@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec k59_692159_2 1089547.KB913013_gene936 4.13e-19 93.2 COG0702@1|root,COG0702@2|Bacteria,4NHVQ@976|Bacteroidetes,47JBM@768503|Cytophagia 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_169849_1 572544.Ilyop_0231 1.77e-64 216.0 COG1032@1|root,COG1032@2|Bacteria,378NN@32066|Fusobacteria 32066|Fusobacteria C Radical SAM N-terminal - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_921484_1 749222.Nitsa_1232 3.78e-125 373.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2YMAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_659991_1 1165841.SULAR_06643 3.74e-44 154.0 COG4625@1|root,COG4625@2|Bacteria,1N0QY@1224|Proteobacteria,4314D@68525|delta/epsilon subdivisions 1224|Proteobacteria S pathogenesis - - - - - - - - - - - - - k59_104272_1 1319815.HMPREF0202_00971 2.81e-26 111.0 COG1196@1|root,COG1196@2|Bacteria,37AJB@32066|Fusobacteria 32066|Fusobacteria D S-layer homology domain - - - - - - - - - - - - SLH k59_986220_1 572544.Ilyop_0198 4.68e-81 254.0 COG1109@1|root,COG1109@2|Bacteria,3788E@32066|Fusobacteria 32066|Fusobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_986220_2 469596.HMPREF9488_02575 1.72e-22 99.4 COG4976@1|root,COG4976@2|Bacteria,1UHZM@1239|Firmicutes,3VUUF@526524|Erysipelotrichia 526524|Erysipelotrichia S Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_25 k59_632484_2 1247963.JPHU01000004_gene564 0.000521 41.6 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E alcohol dehydrogenase tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_402960_1 525898.Sdel_1018 1.31e-69 226.0 COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,42N2D@68525|delta/epsilon subdivisions,2YNAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_1023906_1 1201293.AKXQ01000023_gene4192 7.87e-10 65.1 2DCNX@1|root,2ZESX@2|Bacteria,1QUV9@1224|Proteobacteria,1RRBH@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_567206_1 563040.Saut_1664 6.48e-60 209.0 COG2199@1|root,COG2200@1|root,COG3287@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG3287@2|Bacteria,1RGCV@1224|Proteobacteria,42ZA8@68525|delta/epsilon subdivisions,2YTEP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase - - 3.1.4.52 ko:K20964 ko05111,map05111 - - - ko00000,ko00001,ko01000 - - - EAL,FIST,FIST_C,GGDEF,PAS_9 k59_958575_1 1165841.SULAR_10229 1.7e-97 286.0 COG1943@1|root,COG1943@2|Bacteria,1RG4K@1224|Proteobacteria,42RWC@68525|delta/epsilon subdivisions,2YRM9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Transposase IS200 like - - - - - - - - - - - - - k59_958575_2 240015.ACP_1539 2.61e-69 224.0 2EDN6@1|root,337HX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_402971_1 1121403.AUCV01000031_gene2812 1.68e-74 233.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,42RKW@68525|delta/epsilon subdivisions,2X5I8@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_893464_1 1121937.AUHJ01000003_gene3189 9.59e-84 275.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_175129_1 1168034.FH5T_09300 6.99e-35 132.0 COG0358@1|root,COG0358@2|Bacteria,4NENT@976|Bacteroidetes,2FMV1@200643|Bacteroidia 976|Bacteroidetes L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_175129_2 1168034.FH5T_09305 1.83e-81 243.0 COG3467@1|root,COG3467@2|Bacteria,4NR88@976|Bacteroidetes,2FN3R@200643|Bacteroidia 976|Bacteroidetes S Pyridoxamine 5'-phosphate oxidase family protein - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_535009_1 1168034.FH5T_18250 2.07e-79 259.0 COG1629@1|root,COG4771@2|Bacteria,4PN1J@976|Bacteroidetes,2G0P2@200643|Bacteroidia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,OMP_b-brl_3 k59_599851_1 1165841.SULAR_01035 2.33e-115 353.0 COG0465@1|root,COG0465@2|Bacteria,1NQVB@1224|Proteobacteria,42MWB@68525|delta/epsilon subdivisions,2YR9A@29547|Epsilonproteobacteria 2|Bacteria O Peptidase family M41 - - - - - - - - - - - - AAA,Peptidase_M41 k59_567207_1 279714.FuraDRAFT_2591 1.74e-61 199.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2VIC3@28216|Betaproteobacteria,2KTZH@206351|Neisseriales 206351|Neisseriales S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_109590_2 395019.Bmul_5266 9.41e-23 97.4 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VMAV@28216|Betaproteobacteria,1K1IM@119060|Burkholderiaceae 28216|Betaproteobacteria E Dehydrogenase - - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_697403_1 1165841.SULAR_02463 9.12e-69 220.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2YMC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU twitching motility protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_665564_1 929558.SMGD1_2249 5.84e-147 424.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2YMQU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the HypD family hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_893470_1 1056816.JAFQ01000004_gene3440 1.17e-82 267.0 COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4FUKH@85025|Nocardiaceae 201174|Actinobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation - - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g k59_567214_1 2340.JV46_10670 8.95e-111 333.0 COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1JAKX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Nickel-dependent hydrogenase - - 1.12.1.2 ko:K00436 - - R00700 - ko00000,ko01000 - - - NiFeSe_Hases k59_762249_1 1162668.LFE_1592 6.01e-78 240.0 COG1670@1|root,COG1670@2|Bacteria 2|Bacteria J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins ydaF_1 - - - - - - - - - - - Acetyltransf_3 k59_762249_2 1443111.JASG01000004_gene633 6.28e-72 235.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,3ZVQE@60136|Sulfitobacter 28211|Alphaproteobacteria V ABC transporter transmembrane region msbA2 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_7043_1 709032.Sulku_0876 2.52e-161 462.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2YMTB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_468811_1 387093.SUN_1957 4.58e-132 385.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2YMPK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_632513_1 1187851.A33M_0697 5.2e-11 63.2 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2TRS4@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase, family 39 MA20_30100 - - - - - - - - - - - PMT,PMT_2 k59_632513_2 525903.Taci_1702 4.16e-24 100.0 COG0075@1|root,COG0075@2|Bacteria,3TA05@508458|Synergistetes 508458|Synergistetes E PFAM Aminotransferase - - - - - - - - - - - - Aminotran_5 k59_567217_1 1366050.N234_10460 2.72e-45 157.0 COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria,2VZKC@28216|Betaproteobacteria,1KBNU@119060|Burkholderiaceae 28216|Betaproteobacteria S TGS domain - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS k59_567217_2 1535422.ND16A_1887 1.24e-24 102.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,1RQ1A@1236|Gammaproteobacteria,2Q6Q9@267889|Colwelliaceae 1236|Gammaproteobacteria M PFAM membrane bound O-acyl transferase MBOAT family protein patA - - - - - - - - - - - MBOAT k59_599867_1 1123228.AUIH01000008_gene2354 5.07e-10 61.2 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,1XJ26@135619|Oceanospirillales 135619|Oceanospirillales EGP Sugar (and other) transporter - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_599867_2 1123354.AUDR01000013_gene598 1.47e-29 116.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,1KRC2@119069|Hydrogenophilales 119069|Hydrogenophilales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_339109_1 292.DM42_7104 4.94e-20 95.1 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VMW6@28216|Betaproteobacteria,1K4TB@119060|Burkholderiaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN2 - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_371009_1 1537917.JU82_02895 7.05e-137 397.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2YN2D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_304237_1 397291.C804_04906 1.02e-86 278.0 COG0012@1|root,COG0012@2|Bacteria,1UIBA@1239|Firmicutes,24DM9@186801|Clostridia,27TWJ@186928|unclassified Lachnospiraceae 186801|Clostridia J GTP binding - - - - - - - - - - - - - k59_42295_1 768671.ThimaDRAFT_4832 3.84e-53 176.0 COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,1S59S@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative DNA-binding domain - - - - - - - - - - - - DUF2063 k59_239848_1 1121904.ARBP01000024_gene6666 3.07e-06 49.3 COG1215@1|root,COG1215@2|Bacteria,4NF0S@976|Bacteroidetes,47KDC@768503|Cytophagia 976|Bacteroidetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_304239_1 61647.LG71_21815 1.09e-90 295.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_893488_1 1123073.KB899243_gene470 9.76e-27 112.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1X4MQ@135614|Xanthomonadales 135614|Xanthomonadales NU Tfp pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - TPR_19 k59_893488_2 1279019.ARQK01000058_gene671 1.96e-18 82.8 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1WWMZ@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_42302_2 314231.FP2506_14189 4.58e-23 96.3 COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,2PJ6T@255475|Aurantimonadaceae 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain gst - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_C_3,GST_N_3 k59_599881_1 1168034.FH5T_09600 8.19e-74 230.0 COG0697@1|root,COG0697@2|Bacteria,4NNBQ@976|Bacteroidetes,2FMN9@200643|Bacteroidia 976|Bacteroidetes EG Psort location CytoplasmicMembrane, score 10.00 eamA - - - - - - - - - - - EamA k59_142955_1 1278306.KB906907_gene72 5.01e-144 417.0 COG1960@1|root,COG1960@2|Bacteria,378TZ@32066|Fusobacteria 32066|Fusobacteria C Acyl-CoA dehydrogenase, N-terminal domain bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_142955_2 1280663.ATVR01000002_gene351 1.8e-30 116.0 COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,24AF7@186801|Clostridia,4C0Y1@830|Butyrivibrio 186801|Clostridia G Xylose isomerase-like TIM barrel iolE - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_468822_1 768671.ThimaDRAFT_4690 3.9e-98 297.0 COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WWGR@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_697423_1 1443122.Z958_09160 7.35e-90 282.0 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,36EFF@31979|Clostridiaceae 186801|Clostridia C Na H antiporter - - - - - - - - - - - - Na_H_antiporter k59_339124_1 869213.JCM21142_105 4e-21 92.0 COG2197@1|root,COG2197@2|Bacteria,4NNVV@976|Bacteroidetes 976|Bacteroidetes K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE k59_109615_1 671143.DAMO_2937 1.03e-19 93.2 COG0784@1|root,COG3290@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,2NS4C@2323|unclassified Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SPOB_a k59_175168_1 1121396.KB893051_gene3433 3.86e-18 85.1 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42NGM@68525|delta/epsilon subdivisions,2WKBQ@28221|Deltaproteobacteria,2MK7Q@213118|Desulfobacterales 28221|Deltaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_599886_1 991.IW20_12015 5.1e-30 119.0 COG1333@1|root,COG1333@2|Bacteria,4NGT1@976|Bacteroidetes,1I1G4@117743|Flavobacteriia,2NY8B@237|Flavobacterium 976|Bacteroidetes O ResB-like family ccs1 - - - - - - - - - - - ResB k59_599886_2 1408310.JHUW01000005_gene1603 1.79e-20 90.1 COG0755@1|root,COG0755@2|Bacteria,4NIJZ@976|Bacteroidetes,2FM69@200643|Bacteroidia 976|Bacteroidetes O Psort location CytoplasmicMembrane, score 10.00 ycf - - - - - - - - - - - Cytochrom_C_asm k59_207673_1 1178482.BJB45_18935 1.91e-43 164.0 COG2304@1|root,COG2304@2|Bacteria,1QU09@1224|Proteobacteria,1T5WD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oxidoreductase activity - - - - - - - - - - - - - k59_893508_1 1120983.KB894571_gene2178 1.77e-35 127.0 COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,2VBS3@28211|Alphaproteobacteria,1JQJX@119043|Rhodobiaceae 28211|Alphaproteobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_992157_1 479432.Sros_0727 1.89e-25 110.0 COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4EIMP@85012|Streptosporangiales 201174|Actinobacteria V Beta-lactamase - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase k59_175178_1 1049564.TevJSym_ao00280 1.99e-106 338.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1224|Proteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_271554_1 318161.Sden_2376 2.36e-07 56.2 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S66I@1236|Gammaproteobacteria,2QBJI@267890|Shewanellaceae 1236|Gammaproteobacteria S ErfK YbiS YcfS YnhG IV02_27405 - - - - - - - - - - - YkuD k59_304258_1 305900.GV64_05350 3.51e-134 393.0 COG4804@1|root,COG4804@2|Bacteria,1NBWK@1224|Proteobacteria,1RY9R@1236|Gammaproteobacteria,1XH7A@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1016) - - - - - - - - - - - - DUF1016 k59_304258_2 572544.Ilyop_2932 2.72e-103 302.0 COG1961@1|root,COG1961@2|Bacteria 2|Bacteria L recombinase activity - - - - - - - - - - - - Resolvase k59_240340_2 572544.Ilyop_0145 6.51e-64 206.0 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) VP1287 - - ko:K07003 - - - - ko00000 - - - LolA_like k59_600561_1 1168034.FH5T_06910 4.48e-194 548.0 COG0055@1|root,COG0055@2|Bacteria,4NF1Q@976|Bacteroidetes,2FP0J@200643|Bacteroidia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_304877_1 1121403.AUCV01000024_gene3424 2.47e-64 210.0 COG3875@1|root,COG3875@2|Bacteria,1RHU4@1224|Proteobacteria,42SM9@68525|delta/epsilon subdivisions,2WPUJ@28221|Deltaproteobacteria,2MKWW@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 k59_208388_1 1282876.BAOK01000001_gene1780 4.91e-113 347.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,4BPK2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O C-terminal, D2-small domain, of ClpB protein clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_535581_1 765910.MARPU_06335 1.38e-221 623.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWTP@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K10126,ko:K10943 ko02020,ko05111,map02020,map05111 M00504,M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_535581_2 1121943.KB899999_gene1298 8.38e-161 490.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RQIN@1236|Gammaproteobacteria,1XHAU@135619|Oceanospirillales 135619|Oceanospirillales T Signal transduction histidine kinase - - 2.7.13.3 ko:K10125 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_9,dCache_1 k59_535581_3 1049564.TevJSym_at00720 1.66e-66 206.0 COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,1SAZP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P hemerythrin-like metal-binding - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_535581_4 2340.JV46_23290 3.25e-68 211.0 COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1J5QA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length greB - - ko:K04760 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_535581_5 1049564.TevJSym_ag00370 2.12e-116 341.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1J4PJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0422 IGPS k59_535581_6 2340.JV46_07560 1.39e-163 466.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1J5KW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases yhdH GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0043957,GO:0055114 - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_535581_7 203122.Sde_0091 2.14e-107 317.0 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,1RMKM@1236|Gammaproteobacteria,465F7@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family ydfG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019860,GO:0031132,GO:0034641,GO:0035527,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.1.1.276,1.1.1.313,1.1.1.381 ko:K05886,ko:K15373,ko:K16066 ko00240,ko00260,ko00430,ko01100,map00240,map00260,map00430,map01100 - R02600,R09289,R10851,R10852 RC00087,RC00525,RC03288 ko00000,ko00001,ko01000 - - - adh_short k59_535581_8 395493.BegalDRAFT_0029 2.64e-44 148.0 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,4610Q@72273|Thiotrichales 72273|Thiotrichales S Stringent starvation protein B - - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_535581_9 765911.Thivi_3747 5.53e-91 272.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1WWWN@135613|Chromatiales 135613|Chromatiales O PFAM Glutathione S-transferase sspA - - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_C_2,GST_N_3 k59_535581_10 713586.KB900536_gene1394 4.47e-95 285.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1WWVP@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome C1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_535581_11 1049564.TevJSym_ag00080 1.21e-257 711.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1J5A4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_535581_12 1049564.TevJSym_ag00090 1.2e-96 285.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_535581_13 626887.J057_18340 2.7e-88 269.0 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,1RNBU@1236|Gammaproteobacteria,464UP@72275|Alteromonadaceae 1236|Gammaproteobacteria S NIF3 (NGG1p interacting factor 3) ybgI GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896 - - - - - - - - - - NIF3 k59_535581_14 1049564.TevJSym_ag00110 8.49e-136 400.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain degS GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_535581_15 1049564.TevJSym_ag00170 9.17e-177 502.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1J9QP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II hisC GO:0000105,GO:0003674,GO:0003824,GO:0004400,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - iECO111_1330.ECO111_2745,iSDY_1059.SDY_2220,iSSON_1240.SSON_2092 Aminotran_1_2 k59_535581_16 1049564.TevJSym_ag00180 1.1e-233 652.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1J59J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_535581_17 2340.JV46_17730 1.82e-119 345.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1J5GS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_535581_18 1500893.JQNB01000001_gene1636 2.69e-63 205.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1X48Z@135614|Xanthomonadales 135614|Xanthomonadales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_435807_1 272942.RCAP_rcc01163 7.04e-23 97.4 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,1FB3N@1060|Rhodobacter 28211|Alphaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC fixI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_435807_2 1208323.B30_12497 2.33e-19 79.3 COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,2UJFJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Cytochrome oxidase maturation protein fixS - - - - - - - - - - - FixS k59_435807_3 272942.RCAP_rcc01165 9.27e-14 70.5 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TRCV@28211|Alphaproteobacteria,1FAPB@1060|Rhodobacter 28211|Alphaproteobacteria M Belongs to the peptidase S11 family dacF - 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S11,SPOR k59_861081_2 709032.Sulku_1150 2.39e-59 203.0 COG4774@1|root,COG4774@2|Bacteria,1QU2Y@1224|Proteobacteria,43CFU@68525|delta/epsilon subdivisions,2YTF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M PFAM TonB-dependent Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - TonB_dep_Rec k59_927645_2 1249627.D779_2018 1.17e-33 120.0 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,1S50W@1236|Gammaproteobacteria,1WY7T@135613|Chromatiales 135613|Chromatiales S PFAM Dinitrogenase iron-molybdenum cofactor - - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_762990_1 631362.Thi970DRAFT_01277 2.37e-06 54.3 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,1T3PK@1236|Gammaproteobacteria,1X0PQ@135613|Chromatiales 135613|Chromatiales T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3 k59_992782_1 509635.N824_28355 6.37e-43 162.0 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1IPF5@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_828825_1 536232.CLM_3289 2.21e-70 221.0 COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,36G5G@31979|Clostridiaceae 186801|Clostridia O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_175873_1 177437.HRM2_46600 1.84e-107 321.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,42NNJ@68525|delta/epsilon subdivisions,2WKP9@28221|Deltaproteobacteria,2MKV7@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,DUF2924,Transposase_20 k59_77384_1 709032.Sulku_2115 1.28e-71 238.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,42NNW@68525|delta/epsilon subdivisions,2YN9Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM ABC transporter - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_507803_2 1168034.FH5T_02790 5.88e-154 435.0 COG0169@1|root,COG0169@2|Bacteria,4NEBJ@976|Bacteroidetes,2FP6C@200643|Bacteroidia 976|Bacteroidetes E Shikimate aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_dh_N k59_733978_1 1298867.AUES01000051_gene4506 1.53e-90 287.0 COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria,3K33G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Peptidase, M50 family - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3,PqqD k59_571921_1 1249480.B649_08295 1.87e-78 241.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2YMRV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_571921_2 1537917.JU82_04635 4.79e-33 125.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2YMSF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iIT341.HP1134 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_670651_1 314345.SPV1_08346 7.04e-46 162.0 COG3202@1|root,COG3202@2|Bacteria,1RCHN@1224|Proteobacteria 1224|Proteobacteria P Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism tlc4 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015931,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03301 - - - - ko00000 2.A.12 - - TLC k59_375632_1 37919.EP51_25960 4.18e-08 61.2 COG2207@1|root,COG2207@2|Bacteria,2IBP1@201174|Actinobacteria,4FVP2@85025|Nocardiaceae 201174|Actinobacteria K AraC family transcriptional regulator - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_997117_1 1379270.AUXF01000007_gene996 7.41e-10 65.1 COG0515@1|root,COG0515@2|Bacteria,1ZUIC@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Lipopolysaccharide kinase (Kdo/WaaP) family - - - - - - - - - - - - Pkinase k59_963900_1 765914.ThisiDRAFT_0270 2.56e-25 106.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales 135613|Chromatiales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_637612_2 1300345.LF41_1506 7.46e-11 62.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1X4NB@135614|Xanthomonadales 135614|Xanthomonadales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_114160_1 886377.Murru_0952 2.68e-53 192.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NDXS@976|Bacteroidetes,1HWYV@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec k59_309354_1 1172190.M947_03035 4.84e-121 366.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2YMKH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_46821_1 485917.Phep_2726 7.21e-20 91.3 COG0642@1|root,COG0745@1|root,COG2207@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1IPF5@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_46821_2 1168034.FH5T_00885 3.32e-54 181.0 COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes,2FWNU@200643|Bacteroidia 976|Bacteroidetes S Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_212933_1 522306.CAP2UW1_2214 4.44e-53 180.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2VHRI@28216|Betaproteobacteria 28216|Betaproteobacteria V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_440135_1 385682.AFSL01000089_gene919 2.44e-27 104.0 28VPU@1|root,2ZHRS@2|Bacteria,4NJWU@976|Bacteroidetes,2FQ41@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_571931_1 207559.Dde_1744 6.56e-92 284.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria,2MC15@213115|Desulfovibrionales 28221|Deltaproteobacteria L DDE domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve k59_571931_2 1291050.JAGE01000001_gene1005 1.65e-12 65.9 COG2963@1|root,COG2963@2|Bacteria,1VIRY@1239|Firmicutes,24QMV@186801|Clostridia,3WQF0@541000|Ruminococcaceae 186801|Clostridia L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_28,HTH_Tnp_1 k59_81172_1 1144310.PMI07_002360 8.13e-07 56.6 2DPZ1@1|root,3340X@2|Bacteria,1R2EE@1224|Proteobacteria,2TZIB@28211|Alphaproteobacteria,4BP2Q@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_637625_1 913325.N799_12275 2.28e-78 254.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1X3HM@135614|Xanthomonadales 135614|Xanthomonadales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_605150_1 472759.Nhal_1619 2.99e-110 344.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1X01G@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_507824_1 1408473.JHXO01000005_gene1663 1.02e-47 173.0 COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,4NG9Q@976|Bacteroidetes 976|Bacteroidetes S Uncharacterised conserved protein (DUF2156) - - 2.3.2.3 ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504 2.A.1.3.37 - - DUF2156,LPG_synthase_TM k59_637630_1 1121405.dsmv_2781 1.28e-88 272.0 COG1207@1|root,COG1207@2|Bacteria,1R7DE@1224|Proteobacteria,42N1D@68525|delta/epsilon subdivisions,2WIRZ@28221|Deltaproteobacteria,2MHM4@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain - - 2.7.7.23,2.7.7.83 ko:K00972 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00361,M00362 R00416 RC00002 ko00000,ko00001,ko00002,ko01000 - - - - k59_375640_1 335543.Sfum_0504 1.44e-05 48.9 COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,42VJM@68525|delta/epsilon subdivisions,2WRBG@28221|Deltaproteobacteria,2MSE2@213462|Syntrophobacterales 28221|Deltaproteobacteria K PFAM ROSMUCR transcriptional regulator - - - - - - - - - - - - ROS_MUCR k59_11538_2 1168034.FH5T_07280 4.04e-58 196.0 28HG4@1|root,2Z7S0@2|Bacteria,4NE3G@976|Bacteroidetes,2FNU8@200643|Bacteroidia 976|Bacteroidetes S Gliding motility-associated protein GldM gldM - - - - - - - - - - - GldM_C,GldM_N k59_703288_1 469618.FVAG_00179 7.47e-38 134.0 COG0581@1|root,COG0581@2|Bacteria,379R4@32066|Fusobacteria 32066|Fusobacteria P Binding-protein-dependent transport system inner membrane component pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_703288_2 1408439.JHXW01000002_gene702 5.48e-145 412.0 COG1117@1|root,COG1117@2|Bacteria,378BG@32066|Fusobacteria 32066|Fusobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_703288_3 1121129.KB903374_gene546 1.78e-13 74.7 COG0704@1|root,COG0704@2|Bacteria,4NQ6U@976|Bacteroidetes,2G3C4@200643|Bacteroidia,22Y4F@171551|Porphyromonadaceae 976|Bacteroidetes P PhoU domain - - - ko:K02039 - - - - ko00000 - - - PhoU k59_703288_4 572544.Ilyop_0629 1.09e-109 321.0 COG0745@1|root,COG0745@2|Bacteria,37990@32066|Fusobacteria 32066|Fusobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_703288_5 572544.Ilyop_0630 1.08e-176 517.0 COG5002@1|root,COG5002@2|Bacteria,3788W@32066|Fusobacteria 32066|Fusobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_703288_7 572544.Ilyop_0308 9.61e-36 122.0 COG1918@1|root,COG1918@2|Bacteria,37AMQ@32066|Fusobacteria 32066|Fusobacteria P FeoA - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_703288_8 572544.Ilyop_0309 0.0 1018.0 COG0370@1|root,COG0370@2|Bacteria,37888@32066|Fusobacteria 32066|Fusobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_245332_1 1249627.D779_3324 3.97e-18 80.1 COG0589@1|root,COG0589@2|Bacteria,1NB6E@1224|Proteobacteria,1SEN6@1236|Gammaproteobacteria,1WZ7A@135613|Chromatiales 135613|Chromatiales T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_245332_2 765910.MARPU_02035 3.66e-125 377.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales 135613|Chromatiales P PFAM Na Picotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_440908_1 1123226.KB899284_gene3737 1.2e-30 127.0 COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae 91061|Bacilli K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE k59_47528_1 1537915.JU57_12030 1.39e-64 209.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42NCC@68525|delta/epsilon subdivisions,2YPJ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_964634_1 345201.RPB1_IIV3 2.22e-61 211.0 4QARB@10239|Viruses,4QV3H@35237|dsDNA viruses no RNA stage 10239|Viruses S RNA polymerase Rpb1, domain 3 - GO:0008150,GO:0016032,GO:0019080,GO:0019083,GO:0039695,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_932537_1 670487.Ocepr_1219 6.92e-13 70.9 COG1446@1|root,COG1446@2|Bacteria,1WKGS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E PFAM peptidase T2 asparaginase 2 - - 3.4.19.5 ko:K13051 - - - - ko00000,ko01000,ko01002 - - - Asparaginase_2 k59_148638_1 713586.KB900536_gene1938 5.49e-97 312.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,NB-ARC,cNMP_binding k59_734804_1 1121448.DGI_2643 1.58e-82 257.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_899311_1 485913.Krac_7649 5.71e-58 196.0 COG0818@1|root,COG0818@2|Bacteria,2G75I@200795|Chloroflexi 200795|Chloroflexi M PFAM diacylglycerol kinase - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_964648_1 387093.SUN_0361 1.44e-54 181.0 COG1579@1|root,COG1579@2|Bacteria,1R7GT@1224|Proteobacteria,42P3S@68525|delta/epsilon subdivisions,2YMAN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG1579 Zn-ribbon protein possibly nucleic acid-binding - - 3.5.4.16 ko:K07164,ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - zf-RING_7 k59_11552_1 1168034.FH5T_13065 1.29e-31 126.0 COG0457@1|root,COG0457@2|Bacteria,4NGGZ@976|Bacteroidetes,2FMHN@200643|Bacteroidia 976|Bacteroidetes S tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8 k59_605908_1 1255043.TVNIR_1950 6.99e-83 256.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_768396_1 1123400.KB904768_gene3408 1.25e-205 597.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales 72273|Thiotrichales C Molybdopterin oxidoreductase Fe4S4 domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_932541_1 472759.Nhal_0579 4.9e-142 408.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales 135613|Chromatiales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_47541_1 572544.Ilyop_0810 3.31e-77 234.0 COG1898@1|root,COG1898@2|Bacteria,379FK@32066|Fusobacteria 2|Bacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose - - 4.2.1.46,5.1.3.13 ko:K01710,ko:K01790 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513,R06514 RC00402,RC01531 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd,dTDP_sugar_isom k59_734815_1 1163617.SCD_n00486 9.56e-37 139.0 COG0025@1|root,COG0025@2|Bacteria,1N07S@1224|Proteobacteria,2VP23@28216|Betaproteobacteria 28216|Betaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_734815_2 314285.KT71_14554 1.19e-47 171.0 28MAS@1|root,318XW@2|Bacteria,1NU47@1224|Proteobacteria,1SM4U@1236|Gammaproteobacteria,1J7Z3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 k59_115016_1 1172190.M947_04175 4.29e-149 426.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2YMNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_768405_1 283942.IL0516 1.99e-28 117.0 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1RPY8@1236|Gammaproteobacteria,2QEXY@267893|Idiomarinaceae 1236|Gammaproteobacteria M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_376404_1 1537917.JU82_02675 6.51e-08 53.1 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,42NRV@68525|delta/epsilon subdivisions,2YMK2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_376404_2 929558.SMGD1_1757 1.82e-104 310.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2YMMA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iIT341.HP0202 ACP_syn_III,ACP_syn_III_C k59_148674_1 1298593.TOL_3205 1.38e-11 67.4 2BN8J@1|root,32GW0@2|Bacteria,1RH74@1224|Proteobacteria,1S7A4@1236|Gammaproteobacteria,1XM4F@135619|Oceanospirillales 135619|Oceanospirillales S LPP20 lipoprotein - - - - - - - - - - - - LPP20 k59_245348_1 443152.MDG893_03425 5.45e-73 235.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,464B6@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - DUF1298,WES_acyltransf k59_964664_1 1168034.FH5T_01395 1.62e-26 110.0 COG0668@1|root,COG0668@2|Bacteria,4NE4R@976|Bacteroidetes,2FN78@200643|Bacteroidia 976|Bacteroidetes M COG0668 Small-conductance mechanosensitive channel mscS - - ko:K16053 - - - - ko00000,ko02000 1.A.23.4.5 - - MS_channel k59_572774_1 1168034.FH5T_12120 1.02e-89 266.0 29CCT@1|root,2ZZB9@2|Bacteria,4NM9K@976|Bacteroidetes,2FNRJ@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - PRiA4_ORF3 k59_572774_2 1300143.CCAV010000006_gene4277 2.89e-07 53.1 COG0324@1|root,COG0324@2|Bacteria,4NEAE@976|Bacteroidetes,1HXKT@117743|Flavobacteriia,3ZPA4@59732|Chryseobacterium 976|Bacteroidetes J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_345017_1 983545.Glaag_3727 1.27e-87 289.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RQEQ@1236|Gammaproteobacteria,46A77@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_932566_2 748658.KB907312_gene1683 1.96e-37 143.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales 135613|Chromatiales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_115041_1 709032.Sulku_1577 1.52e-91 275.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2YMHA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_115041_2 504728.K649_01765 1.61e-14 68.9 COG1324@1|root,COG1324@2|Bacteria,1WKG6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P PFAM CutA1 divalent ion tolerance protein cutA - - ko:K03926 - - - - ko00000 - - - CutA1 k59_932573_1 1321778.HMPREF1982_01395 0.000118 45.4 COG1177@1|root,COG1177@2|Bacteria,1URBC@1239|Firmicutes,24801@186801|Clostridia,26B5U@186813|unclassified Clostridiales 186801|Clostridia E Binding-protein-dependent transport system inner membrane component - - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_932573_2 198467.NP92_08505 6.5e-38 142.0 COG1176@1|root,COG1176@2|Bacteria,1V1K7@1239|Firmicutes,4HG7A@91061|Bacilli 91061|Bacilli E transport system, permease component - - - ko:K02054 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_932573_3 1526927.Plano_1477 1.11e-95 293.0 COG4134@1|root,COG4134@2|Bacteria,1TR3G@1239|Firmicutes,4HAW1@91061|Bacilli,26H10@186818|Planococcaceae 91061|Bacilli S Bacterial extracellular solute-binding protein - - - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - SBP_bac_8 k59_82028_1 1348657.M622_04820 1.74e-74 245.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2VMQV@28216|Betaproteobacteria,2KXK7@206389|Rhodocyclales 206389|Rhodocyclales P Flavin-binding monooxygenase-like - - - ko:K07222 - - - - ko00000 - - - FMO-like,K_oxygenase k59_310138_1 713586.KB900536_gene1201 7.43e-42 142.0 COG0526@1|root,COG0526@2|Bacteria,1RDGI@1224|Proteobacteria,1S8ZA@1236|Gammaproteobacteria,1X1I8@135613|Chromatiales 135613|Chromatiales CO Glutathione peroxidase - - - - - - - - - - - - AhpC-TSA,Redoxin k59_310138_2 864702.OsccyDRAFT_4357 6.78e-10 58.2 COG1981@1|root,COG1981@2|Bacteria,1G18U@1117|Cyanobacteria,1H8D3@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Uncharacterised protein family (UPF0093) - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_964684_1 1249627.D779_3611 6.84e-139 412.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales 135613|Chromatiales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_997920_1 1123504.JQKD01000012_gene1362 2.11e-40 146.0 COG3751@1|root,COG3751@2|Bacteria,1NG7K@1224|Proteobacteria,2VK5Y@28216|Betaproteobacteria,4AAXY@80864|Comamonadaceae 28216|Betaproteobacteria O SMART Prolyl 4-hydroxylase, alpha subunit - - 1.14.11.2 ko:K00472 ko00330,ko01100,map00330,map01100 - R01252 RC00478 ko00000,ko00001,ko01000 - - - 2OG-FeII_Oxy_3 k59_508595_1 1283300.ATXB01000002_gene3052 3.57e-16 83.2 COG4262@1|root,COG4262@2|Bacteria,1QUPY@1224|Proteobacteria,1RMJV@1236|Gammaproteobacteria,1XFY9@135618|Methylococcales 135618|Methylococcales S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth k59_997921_1 749222.Nitsa_1505 9.32e-22 88.6 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2YPEP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_932579_1 1123368.AUIS01000032_gene1394 4.94e-63 208.0 COG1080@1|root,COG1080@2|Bacteria 2|Bacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_932579_2 935567.JAES01000001_gene2285 2.06e-14 72.8 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1X523@135614|Xanthomonadales 135614|Xanthomonadales J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_181314_1 1408473.JHXO01000010_gene3670 7.16e-41 147.0 COG4677@1|root,COG4677@2|Bacteria,4NEEI@976|Bacteroidetes,2FMFM@200643|Bacteroidia 976|Bacteroidetes G Pectinesterase rhgT_2 - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Lipase_GDSL_2,Pectinesterase k59_508605_1 387093.SUN_0664 2.81e-104 310.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2YM8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_734867_1 1120973.AQXL01000132_gene2202 1.45e-83 260.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4HA5K@91061|Bacilli,2785X@186823|Alicyclobacillaceae 91061|Bacilli E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_932594_1 1485545.JQLW01000013_gene1811 1.67e-26 112.0 COG0025@1|root,COG0025@2|Bacteria 2|Bacteria P sodium:proton antiporter activity - - - ko:K03316 - - - - ko00000 2.A.36 - - GGDEF,Na_H_Exchanger k59_605954_1 715451.ambt_19570 8.27e-48 166.0 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,1RQBC@1236|Gammaproteobacteria,465JI@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG1253 Hemolysins and related proteins containing CBS domains - - - - - - - - - - - - CBS,DUF21 k59_899367_1 445975.COLSTE_02244 1.11e-10 62.0 COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4CUFP@84998|Coriobacteriia 84998|Coriobacteriia M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase k59_899367_2 572544.Ilyop_1532 2.47e-88 268.0 COG0462@1|root,COG0462@2|Bacteria,3784I@32066|Fusobacteria 32066|Fusobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_671505_1 909943.HIMB100_00002970 5.8e-62 201.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,4BPFY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_115076_1 1218084.BBJK01000055_gene4241 2.23e-101 305.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2VJ99@28216|Betaproteobacteria,1K1C0@119060|Burkholderiaceae 28216|Betaproteobacteria S VWA containing CoxE family protein - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_540825_1 1123518.ARWI01000001_gene1965 0.000103 45.1 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,45ZTP@72273|Thiotrichales 72273|Thiotrichales S Flavocytochrome c sulphide dehydrogenase, flavin-binding - - 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2 k59_82054_1 742725.HMPREF9450_00695 5.06e-17 79.0 COG1214@1|root,COG1214@2|Bacteria,4NDUR@976|Bacteroidetes,2FPYK@200643|Bacteroidia,22UD1@171550|Rikenellaceae 976|Bacteroidetes O Glycoprotease family yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_280931_1 1168034.FH5T_01830 1.37e-49 174.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,2FM7I@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_936798_1 679935.Alfi_1945 1.96e-07 52.4 COG0597@1|root,COG0597@2|Bacteria,4NEZN@976|Bacteroidetes,2FS30@200643|Bacteroidia,22URY@171550|Rikenellaceae 976|Bacteroidetes MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_936798_2 1408473.JHXO01000001_gene2113 4.31e-66 202.0 COG1734@1|root,COG1734@2|Bacteria,4NNID@976|Bacteroidetes,2FSI2@200643|Bacteroidia 976|Bacteroidetes T RNA polymerase-binding protein DksA yocK - - - - - - - - - - - zf-dskA_traR k59_870342_2 283699.D172_3103 2.19e-49 169.0 COG5505@1|root,COG5505@2|Bacteria,1MW87@1224|Proteobacteria,1RQPZ@1236|Gammaproteobacteria,2Q0KK@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S integral membrane protein - - - - - - - - - - - - DUF819 k59_1002270_1 1304275.C41B8_12504 8.02e-76 243.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - iECO103_1326.ECO103_1114 MVIN k59_380754_1 1049564.TevJSym_ad01400 2.49e-09 57.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1J52I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_380754_2 765911.Thivi_3343 8.84e-155 446.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria,1WWQU@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_380754_3 713586.KB900536_gene585 1.45e-197 561.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales 135613|Chromatiales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_380754_4 768671.ThimaDRAFT_3351 5.2e-122 353.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1WX56@135613|Chromatiales 135613|Chromatiales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_380754_5 261292.Nit79A3_2632 1.21e-74 232.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,372H2@32003|Nitrosomonadales 28216|Betaproteobacteria S HAD-superfamily hydrolase, subfamily IA, variant 1 gph - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_380754_6 999141.GME_16072 1.9e-99 297.0 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XH47@135619|Oceanospirillales 135619|Oceanospirillales IQ reductase - - - - - - - - - - - - adh_short k59_380754_7 1269813.ATUL01000031_gene1387 1.44e-34 141.0 COG2199@1|root,COG2202@1|root,COG3290@1|root,COG2202@2|Bacteria,COG3290@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1T4M3@1236|Gammaproteobacteria,1WY59@135613|Chromatiales 135613|Chromatiales T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_380754_8 1437824.BN940_02756 2.04e-82 250.0 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2VQAQ@28216|Betaproteobacteria,3T3MQ@506|Alcaligenaceae 28216|Betaproteobacteria J RNA pseudouridylate synthase rluE - 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_380754_9 2340.JV46_21300 3.3e-53 176.0 2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,1SFME@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_380754_10 1123401.JHYQ01000018_gene2401 4.12e-174 496.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,45ZSN@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_380754_11 1484158.PSNIH1_12060 2.1e-29 115.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,3VYMB@53335|Pantoea 1236|Gammaproteobacteria S High frequency lysogenization protein HflD homolog hflD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562 - ko:K07153 - - - - ko00000 - - - DUF489 k59_380754_13 1049564.TevJSym_ad01330 2.21e-273 754.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1J4V5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_380754_14 572477.Alvin_0841 2.51e-27 108.0 COG2153@1|root,COG2153@2|Bacteria,1N7TN@1224|Proteobacteria,1SCI6@1236|Gammaproteobacteria,1WYQK@135613|Chromatiales 135613|Chromatiales S protein acetylation - - - - - - - - - - - - - k59_380754_15 105559.Nwat_0982 1.76e-27 114.0 COG1450@1|root,COG1450@2|Bacteria,1NC06@1224|Proteobacteria,1T2R0@1236|Gammaproteobacteria,1X25N@135613|Chromatiales 135613|Chromatiales NU Type ii and iii secretion system protein - - - - - - - - - - - - Secretin_N k59_380754_16 314345.SPV1_12255 1.05e-124 363.0 COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria 1224|Proteobacteria M mechano-sensitive ion channel mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_380754_17 1049564.TevJSym_as00640 0.0 941.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1J4D8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair rapA GO:0000166,GO:0001000,GO:0003674,GO:0003676,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - Helicase_C,RapA_C,SNF2_N k59_380754_18 380703.AHA_3765 3.25e-57 190.0 COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1Y4D1@135624|Aeromonadales 135624|Aeromonadales L NUDIX domain nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_380754_19 713587.THITH_01400 2.59e-247 683.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_380754_20 396588.Tgr7_1548 6.74e-15 70.9 COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria 1224|Proteobacteria L Competence protein ComEA comEA GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 k59_314408_1 1129794.C427_2779 3.21e-55 201.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_577217_1 572544.Ilyop_0148 1.51e-83 258.0 COG0859@1|root,COG0859@2|Bacteria,378YY@32066|Fusobacteria 32066|Fusobacteria M heptosyltransferase - - - - - - - - - - - - Glyco_transf_9 k59_478278_1 396595.TK90_2186 8.79e-14 76.3 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1WW7R@135613|Chromatiales 135613|Chromatiales NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_772846_1 1131553.JIBI01000030_gene2443 7.09e-81 258.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,2VJP0@28216|Betaproteobacteria,3721K@32003|Nitrosomonadales 28216|Betaproteobacteria HJ RimK-like ATPgrasp N-terminal domain rimK - - - - - - - - - - - RLAN,RimK k59_903620_1 1123517.JOMR01000001_gene1508 1.54e-101 307.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,4602E@72273|Thiotrichales 72273|Thiotrichales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_802153_1 2340.JV46_07980 2.17e-71 226.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1J4J2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_280955_1 1165841.SULAR_04117 1.87e-20 94.7 COG1196@1|root,COG1196@2|Bacteria,1QUJ1@1224|Proteobacteria,42P7I@68525|delta/epsilon subdivisions,2YMKS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 k59_838220_1 1168034.FH5T_00400 2.67e-42 148.0 COG0760@1|root,COG0760@2|Bacteria,4NG2P@976|Bacteroidetes,2FMWD@200643|Bacteroidia 976|Bacteroidetes O COG NOG23400 non supervised orthologous group - - - - - - - - - - - - Rotamase_2 k59_838220_2 1168034.FH5T_00395 2.85e-52 182.0 COG0760@1|root,COG0760@2|Bacteria,4NGIR@976|Bacteroidetes,2FNS9@200643|Bacteroidia 976|Bacteroidetes M peptidylprolyl isomerase - - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 k59_870360_1 1121447.JONL01000002_gene1807 0.000177 47.8 COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,42TI1@68525|delta/epsilon subdivisions,2WQ9N@28221|Deltaproteobacteria,2MDQ0@213115|Desulfovibrionales 28221|Deltaproteobacteria S Ankyrin repeat - - - - - - - - - - - - Ank,Ank_2,Ank_3,Ank_4,Ank_5 k59_870363_1 439235.Dalk_0268 4.64e-74 240.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_544836_1 1192124.LIG30_1253 3.25e-19 79.3 COG1773@1|root,COG1773@2|Bacteria,1N6TQ@1224|Proteobacteria,2VWD0@28216|Betaproteobacteria,1K9A5@119060|Burkholderiaceae 28216|Betaproteobacteria C Rubredoxin hoxR - - - - - - - - - - - Rubredoxin k59_544836_2 1458427.BAWN01000033_gene1895 9.58e-59 196.0 COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2VKNQ@28216|Betaproteobacteria,4AG9E@80864|Comamonadaceae 28216|Betaproteobacteria C HupH hydrogenase expression protein, C-terminal conserved region hoxQ - - ko:K03618 - - - - ko00000 - - - HupH_C k59_802170_1 1165841.SULAR_07295 2.65e-127 382.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2YMUE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_16163_1 387092.NIS_1830 3.18e-11 59.7 COG2033@1|root,COG2033@2|Bacteria,1NNT5@1224|Proteobacteria,42TKZ@68525|delta/epsilon subdivisions,2YPSG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_16163_2 929558.SMGD1_0059 3.59e-65 206.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,42MIC@68525|delta/epsilon subdivisions,2YN8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Thiosulfate-oxidizing multienzyme system protein SoxA - - - ko:K17222 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - - k59_1033662_2 1172190.M947_09925 8.43e-45 153.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,42QY6@68525|delta/epsilon subdivisions,2YNYW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the inositol monophosphatase superfamily cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_349423_1 926561.KB900618_gene315 8.5e-78 241.0 COG2834@1|root,COG2834@2|Bacteria,1V6F3@1239|Firmicutes,24MGP@186801|Clostridia,3WAQP@53433|Halanaerobiales 186801|Clostridia M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_544843_1 1265313.HRUBRA_01684 3.9e-21 87.8 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1J5R2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria A 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_544843_2 1123073.KB899241_gene1855 3.98e-104 311.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1X3CD@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_478295_2 288000.BBta_4342 2.61e-73 266.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,3JTGV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_478295_3 1049564.TevJSym_ak00930 2.98e-111 324.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1J5G3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA GO:0003674,GO:0003824,GO:0004751,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_478295_5 1122201.AUAZ01000006_gene3870 8.73e-39 137.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,467AN@72275|Alteromonadaceae 1236|Gammaproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 5-FTHF_cyc-lig k59_903658_1 96561.Dole_1470 1.76e-59 206.0 COG0457@1|root,COG2203@1|root,COG2204@1|root,COG0457@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BR8@68525|delta/epsilon subdivisions,2X724@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Sigma54_activat k59_185664_1 1123326.JFBL01000009_gene861 3.35e-28 116.0 COG1293@1|root,COG1293@2|Bacteria,1R54S@1224|Proteobacteria,42MYG@68525|delta/epsilon subdivisions,2YT8X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K RNA-binding protein homologous to eukaryotic snRNP - - - - - - - - - - - - DUF814,FbpA k59_870375_1 1165841.SULAR_05738 1.64e-95 284.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2YMZQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_413021_1 1034807.FBFL15_2915 3.32e-44 150.0 COG3637@1|root,COG3637@2|Bacteria,4NY09@976|Bacteroidetes,1IIAD@117743|Flavobacteriia 976|Bacteroidetes M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl k59_544860_1 1123355.JHYO01000008_gene2679 1.72e-104 318.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,36ZEK@31993|Methylocystaceae 28211|Alphaproteobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_314466_1 933262.AXAM01000057_gene1533 1.19e-120 351.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria,2MI3X@213118|Desulfobacterales 28221|Deltaproteobacteria E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_610211_1 1168034.FH5T_10215 1.14e-117 346.0 COG3203@1|root,COG3203@2|Bacteria,4NMHJ@976|Bacteroidetes,2FT17@200643|Bacteroidia 976|Bacteroidetes M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_380844_1 1286632.P278_19050 0.000585 47.4 COG4932@1|root,COG4932@2|Bacteria,4NRKG@976|Bacteroidetes,1I33J@117743|Flavobacteriia 976|Bacteroidetes M domain protein - - - - - - - - - - - - - k59_936901_1 439235.Dalk_5191 8.78e-32 126.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria,2MIWR@213118|Desulfobacterales 1224|Proteobacteria C PFAM CoA-binding domain protein MA20_15065 - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_936907_1 1121921.KB898710_gene602 1.15e-26 109.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,2PN3X@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_119635_1 1034943.BN1094_00184 1.74e-88 284.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1JC56@118969|Legionellales 118969|Legionellales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_1033699_1 930166.CD58_08610 6.95e-28 113.0 COG2199@1|root,COG3706@2|Bacteria,1RDI8@1224|Proteobacteria,1S436@1236|Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - GGDEF k59_445425_1 1038869.AXAN01000102_gene4464 1.48e-26 108.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria,1K2WR@119060|Burkholderiaceae 28216|Betaproteobacteria S transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_445425_2 1408428.JNJP01000007_gene1867 5.45e-10 61.2 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,2M7XS@213115|Desulfovibrionales 28221|Deltaproteobacteria D TIGRFAM Tyrosine recombinase XerD xerD - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_773691_1 1168034.FH5T_11735 1.34e-177 504.0 COG0128@1|root,COG0128@2|Bacteria,4NE8T@976|Bacteroidetes,2FNY8@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_545595_1 1499686.BN1079_02296 4.33e-115 329.0 COG0454@1|root,COG0456@2|Bacteria,1NII2@1224|Proteobacteria,1SJB0@1236|Gammaproteobacteria 1236|Gammaproteobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_186518_1 1168034.FH5T_21745 2.73e-182 526.0 COG1216@1|root,COG1216@2|Bacteria,4NFW5@976|Bacteroidetes,2FQ14@200643|Bacteroidia 976|Bacteroidetes S Glycosyltransferase, group 2 family protein wbbL - - ko:K07011 - - - - ko00000 - - - CoA_binding_3,Glyco_tranf_2_3,Glycos_transf_2 k59_218955_1 1165841.SULAR_02788 4.91e-78 259.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2YNJ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cznA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_381646_1 1049564.TevJSym_av00360 1.52e-90 288.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J4UY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU general secretion pathway protein D xcsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_381646_2 1177181.T9A_02949 1.8e-32 126.0 COG3031@1|root,COG3031@2|Bacteria,1RK5N@1224|Proteobacteria,1S7YM@1236|Gammaproteobacteria,1XKFU@135619|Oceanospirillales 135619|Oceanospirillales U Type II secretion system protein C - - - ko:K02452 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSC k59_773700_2 1408287.AXUR01000081_gene2153 8e-37 128.0 COG0718@1|root,COG0718@2|Bacteria,37AJZ@32066|Fusobacteria 32066|Fusobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_773700_3 572544.Ilyop_0654 2.46e-85 258.0 COG2121@1|root,COG2121@2|Bacteria,379T5@32066|Fusobacteria 32066|Fusobacteria S K02527 3-deoxy-D-manno-octulosonic-acid transferase - - - ko:K09778 - - - - ko00000 - - - DUF374 k59_773700_4 1209989.TepiRe1_1677 4.46e-26 109.0 COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,42FJX@68295|Thermoanaerobacterales 186801|Clostridia C Belongs to the PdxA family pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1034462_1 1163617.SCD_n02724 1.89e-28 114.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VJK5@28216|Betaproteobacteria 28216|Betaproteobacteria G pyruvate phosphate dikinase ppdK - 2.7.9.1,2.7.9.2 ko:K01006,ko:K01007 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1034462_2 1123229.AUBC01000034_gene1364 0.000104 47.4 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,3K3W8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_513964_1 1168034.FH5T_07295 3.44e-70 222.0 COG0226@1|root,COG0226@2|Bacteria,4PKGM@976|Bacteroidetes,2G3GH@200643|Bacteroidia 976|Bacteroidetes P Type IX secretion system membrane protein PorP/SprF - - - - - - - - - - - - PorP_SprF k59_904540_1 745310.G432_10735 1.11e-37 142.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,2K0RP@204457|Sphingomonadales 204457|Sphingomonadales I Belongs to the enoyl-CoA hydratase isomerase family - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_970016_1 246199.CUS_4899 7.01e-46 155.0 COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,3WGGC@541000|Ruminococcaceae 186801|Clostridia C domain protein nfnA - 1.18.1.2,1.19.1.1 ko:K00528,ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146,R10159 RC00065 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_970016_2 1226322.HMPREF1545_02488 9.65e-45 157.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,2N6JY@216572|Oscillospiraceae 186801|Clostridia E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_610994_1 1168034.FH5T_05685 2.38e-43 150.0 COG2067@1|root,COG2067@2|Bacteria,4NDZW@976|Bacteroidetes,2FPVJ@200643|Bacteroidia 976|Bacteroidetes I Psort location OuterMembrane, score porV - - - - - - - - - - - - k59_610994_2 1168034.FH5T_05680 1.93e-61 191.0 COG0245@1|root,COG0245@2|Bacteria,4NP0N@976|Bacteroidetes,2FNVA@200643|Bacteroidia 976|Bacteroidetes H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB k59_972178_2 697282.Mettu_2235 2.1e-45 157.0 COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,1SAB5@1236|Gammaproteobacteria,1XFPV@135618|Methylococcales 135618|Methylococcales K Transcriptional regulator - - - - - - - - - - - - DUF1956,TetR_N k59_1005296_1 91464.S7335_5034 2e-40 139.0 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1GYT4@1129|Synechococcus 1117|Cyanobacteria C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_775975_1 93220.LV28_06615 1.4e-54 190.0 COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria,1MVYR@1224|Proteobacteria,2VK0V@28216|Betaproteobacteria,1K123@119060|Burkholderiaceae 28216|Betaproteobacteria E 3-isopropylmalate dehydratase - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_448564_1 484770.UFO1_3813 9.28e-121 359.0 COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,4H3AY@909932|Negativicutes 909932|Negativicutes M Glycosyl transferase family group 2 - - - ko:K11936 ko02026,map02026 - - - ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.2,4.D.1.1.3 GT2 - Glyco_tranf_2_3 k59_481171_1 396588.Tgr7_0517 9.89e-150 433.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_156276_2 1408473.JHXO01000010_gene3639 1.23e-57 189.0 COG0151@1|root,COG0151@2|Bacteria,4NK50@976|Bacteroidetes 976|Bacteroidetes F Belongs to the GarS family - - - - - - - - - - - - ATP-grasp_3 k59_188730_1 387093.SUN_1858 7.9e-77 248.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2YMEZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thiol disulfide interchange protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7 k59_284013_1 1158756.AQXQ01000007_gene265 1.28e-49 167.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1WWN0@135613|Chromatiales 135613|Chromatiales L TIGRFAM Phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_710828_2 983545.Glaag_0144 2.24e-39 147.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,464D8@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_841225_1 1165841.SULAR_07795 1.62e-80 253.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42MYT@68525|delta/epsilon subdivisions,2YMKP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_19133_1 335283.Neut_0703 7.38e-83 267.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales 28216|Betaproteobacteria I acyl-CoA dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_873535_1 1123393.KB891316_gene1799 2.06e-08 60.8 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1KRH8@119069|Hydrogenophilales 119069|Hydrogenophilales L Helix-hairpin-helix class 2 (Pol1 family) motifs - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_221117_1 1168034.FH5T_14390 4.03e-76 230.0 COG1778@1|root,COG1778@2|Bacteria,4NMHD@976|Bacteroidetes,2FTGQ@200643|Bacteroidia 976|Bacteroidetes S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - HAD_2,Hydrolase_3 k59_776002_1 1123065.ATWL01000011_gene109 2.27e-59 185.0 COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria 201174|Actinobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_776002_2 562973.HMPREF0059_00032 1.53e-24 93.2 COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,4D6F8@85005|Actinomycetales 201174|Actinobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_352405_1 1232437.KL662063_gene3993 7.58e-57 187.0 COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,42S07@68525|delta/epsilon subdivisions,2WNR0@28221|Deltaproteobacteria,2MKBT@213118|Desulfobacterales 28221|Deltaproteobacteria U Flp pilus assembly protein RcpC/CpaB - - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - ChapFlgA,RcpC,SAF k59_580152_1 1537917.JU82_00650 5.46e-45 157.0 COG1293@1|root,COG1293@2|Bacteria,1R54S@1224|Proteobacteria,42MYG@68525|delta/epsilon subdivisions,2YT8X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K RNA-binding protein homologous to eukaryotic snRNP - - - - - - - - - - - - DUF814,FbpA k59_580152_2 1537917.JU82_00645 8.79e-25 96.3 2ANKR@1|root,31DJY@2|Bacteria,1QAVT@1224|Proteobacteria,42VKM@68525|delta/epsilon subdivisions,2YQB6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_873546_1 1381123.AYOD01000055_gene508 4.99e-34 125.0 COG4665@1|root,COG4665@2|Bacteria,1RDYM@1224|Proteobacteria,2TVMY@28211|Alphaproteobacteria,43KKI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_679213_2 439235.Dalk_0403 1.2e-51 173.0 COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2MI4K@213118|Desulfobacterales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_383997_1 383381.EH30_04550 2.88e-19 88.2 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K2G6@204457|Sphingomonadales 204457|Sphingomonadales EQ COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_841251_1 1232437.KL662030_gene2453 3.28e-99 303.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2MHXE@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_156331_1 107636.JQNK01000009_gene3513 6.08e-94 289.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_156332_1 1304885.AUEY01000004_gene963 1.64e-67 212.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2MIB0@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM AAA ATPase central domain protein - - - - - - - - - - - - AAA,AAA_5 k59_156332_2 96561.Dole_0048 1.87e-12 66.2 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2MIB1@213118|Desulfobacterales 28221|Deltaproteobacteria S VWA containing CoxE family protein - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_221149_1 933262.AXAM01000042_gene1810 3.1e-54 183.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MIYV@213118|Desulfobacterales 28221|Deltaproteobacteria NU Type II secretion system (T2SS), protein F - - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_221149_2 1131269.AQVV01000007_gene988 4.52e-10 57.8 COG2165@1|root,COG2165@2|Bacteria 2|Bacteria NU general secretion pathway protein gspG - - ko:K02246,ko:K02456 ko03070,ko05111,map03070,map05111 M00331,M00429 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_679231_1 1168034.FH5T_10525 4.31e-109 332.0 COG1884@1|root,COG1884@2|Bacteria,4NDVE@976|Bacteroidetes,2FM0R@200643|Bacteroidia 976|Bacteroidetes I Methylmalonyl-CoA mutase mutA - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_841253_1 382464.ABSI01000011_gene2585 1.27e-118 360.0 COG3039@1|root,COG3039@2|Bacteria,46WXW@74201|Verrucomicrobia,2IWQD@203494|Verrucomicrobiae 74201|Verrucomicrobia L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_352430_1 272560.BPSL0768 4.15e-23 98.2 2B6ZF@1|root,31ZZQ@2|Bacteria,1R56K@1224|Proteobacteria,2WE6Z@28216|Betaproteobacteria,1KBYU@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_352430_2 1122915.AUGY01000085_gene6141 1.28e-20 91.7 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - DUF3638,DUF853,DUF87,Hydrolase_3 k59_89844_1 1347087.CBYO010000004_gene318 2.09e-17 83.2 COG1131@1|root,COG1131@2|Bacteria,1TRNT@1239|Firmicutes,4HB3P@91061|Bacilli 91061|Bacilli V ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_89844_2 290317.Cpha266_2528 0.000414 42.7 COG2267@1|root,COG2267@2|Bacteria,1FDIN@1090|Chlorobi 1090|Chlorobi I PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1 k59_873581_1 929558.SMGD1_1620 3.08e-130 377.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2YMMK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_384033_1 1121937.AUHJ01000004_gene948 1.54e-100 318.0 COG1629@1|root,COG4771@2|Bacteria,1QYDM@1224|Proteobacteria,1RYCH@1236|Gammaproteobacteria,469WZ@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_252993_1 358681.BBR47_39880 7.93e-52 187.0 COG0236@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksJ - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_221168_1 1307759.JOMJ01000003_gene954 1.35e-85 280.0 COG3515@1|root,COG5283@1|root,COG5412@1|root,COG3515@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,1P1DE@1224|Proteobacteria,42PIK@68525|delta/epsilon subdivisions,2WKHC@28221|Deltaproteobacteria,2M9DQ@213115|Desulfovibrionales 28221|Deltaproteobacteria S TIGRFAM Phage tail tape measure protein TP901 - - - - - - - - - - - - PhageMin_Tail k59_481222_2 96561.Dole_0421 2.11e-33 129.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42MQJ@68525|delta/epsilon subdivisions,2WJIX@28221|Deltaproteobacteria,2MKQF@213118|Desulfobacterales 28221|Deltaproteobacteria P E1-E2 ATPase - - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase k59_548125_1 234267.Acid_1749 1.97e-65 213.0 COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,3Y652@57723|Acidobacteria 57723|Acidobacteria G alpha beta - - - - - - - - - - - - - k59_1036861_1 1049564.TevJSym_as00200 6.03e-85 264.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1J4RZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - iSDY_1059.SDY_4251 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_284635_1 929558.SMGD1_0348 7.85e-23 95.9 COG0457@1|root,COG0457@2|Bacteria,1N9AG@1224|Proteobacteria,42QUG@68525|delta/epsilon subdivisions,2YP2D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3137) - - - - - - - - - - - - DUF3137 k59_284635_2 387092.NIS_0507 1.29e-40 140.0 COG3054@1|root,COG3054@2|Bacteria,1REC3@1224|Proteobacteria,42UI1@68525|delta/epsilon subdivisions,2YQ06@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Bacterial protein of unknown function (YtfJ_HI0045) - - - ko:K07109 - - - - ko00000 - - - YtfJ_HI0045 k59_189539_1 572544.Ilyop_0579 3.78e-159 475.0 COG0525@1|root,COG0525@2|Bacteria,378RD@32066|Fusobacteria 32066|Fusobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_189539_2 572544.Ilyop_0580 1.27e-133 387.0 COG0583@1|root,COG0583@2|Bacteria,3792W@32066|Fusobacteria 32066|Fusobacteria K Psort location Cytoplasmic, score 9.97 - - - - - - - - - - - - HTH_1,LysR_substrate k59_189539_3 742767.HMPREF9456_01934 1.63e-59 191.0 COG0279@1|root,COG0279@2|Bacteria,4NJX7@976|Bacteroidetes,2FSAT@200643|Bacteroidia,22YKV@171551|Porphyromonadaceae 976|Bacteroidetes G SIS domain gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_742727_1 595460.RRSWK_01011 7.55e-45 154.0 COG0057@1|root,COG0057@2|Bacteria,2IX66@203682|Planctomycetes 2|Bacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap3 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_742727_2 768671.ThimaDRAFT_3701 3.51e-32 119.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1X0CI@135613|Chromatiales 135613|Chromatiales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_711537_1 443143.GM18_2389 5.76e-73 232.0 COG0599@1|root,COG1917@1|root,COG0599@2|Bacteria,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,42SSF@68525|delta/epsilon subdivisions,2WPME@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Cupin domain - - - - - - - - - - - - Cupin_2 k59_157269_1 1163408.UU9_01984 9.97e-58 189.0 COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1RN1S@1236|Gammaproteobacteria,1X448@135614|Xanthomonadales 135614|Xanthomonadales L Exodeoxyribonuclease IX exo - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_1037778_1 1168034.FH5T_11085 4.35e-191 553.0 COG0525@1|root,COG0525@2|Bacteria,4NETB@976|Bacteroidetes,2FPJG@200643|Bacteroidia 976|Bacteroidetes J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_874325_1 1408473.JHXO01000001_gene2348 2.83e-54 176.0 COG0652@1|root,COG0652@2|Bacteria,4NRWP@976|Bacteroidetes,2FY2X@200643|Bacteroidia 976|Bacteroidetes M Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03767 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_253669_1 349741.Amuc_1222 2.07e-59 202.0 COG1297@1|root,COG1297@2|Bacteria,46TNW@74201|Verrucomicrobia,2IV9P@203494|Verrucomicrobiae 203494|Verrucomicrobiae S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT k59_481731_1 1537917.JU82_06795 2.25e-71 232.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42NK1@68525|delta/epsilon subdivisions,2YMHN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the AAA ATPase family ftsH1 - - - - - - - - - - - AAA,Peptidase_M41 k59_123426_1 1348657.M622_10730 6.84e-107 321.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,2KVI2@206389|Rhodocyclales 206389|Rhodocyclales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_123426_2 396588.Tgr7_2894 1.44e-28 111.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1WVWR@135613|Chromatiales 135613|Chromatiales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1005975_1 3641.EOX93900 0.000139 49.3 COG2273@1|root,2RXRM@2759|Eukaryota,37U6M@33090|Viridiplantae,3GHW0@35493|Streptophyta 35493|Streptophyta G Catalyzes xyloglucan endohydrolysis (XEH) and or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues - - 2.4.1.207 ko:K08235 - - - - ko00000,ko01000 - - - Glyco_hydro_16,XET_C k59_805986_1 159087.Daro_2223 4.89e-108 322.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2VMP0@28216|Betaproteobacteria 28216|Betaproteobacteria L Pfam Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_55654_1 1227349.C170_26968 1.56e-36 141.0 COG0507@1|root,COG1112@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,1TP20@1239|Firmicutes,4IQB6@91061|Bacilli,26VKC@186822|Paenibacillaceae 91061|Bacilli L COG1112 Superfamily I DNA and RNA helicases and helicase subunits - - - - - - - - - - - - AAA_11,AAA_12,DUF2726 k59_581123_1 96561.Dole_1668 2.77e-42 146.0 2CCV8@1|root,2Z7KX@2|Bacteria,1MY2J@1224|Proteobacteria,42PUV@68525|delta/epsilon subdivisions,2WKCH@28221|Deltaproteobacteria,2MJRG@213118|Desulfobacterales 28221|Deltaproteobacteria S EcsC protein family - - - - - - - - - - - - EcsC k59_123430_1 1168034.FH5T_20740 1.46e-84 257.0 COG2207@1|root,COG2207@2|Bacteria,4NJYE@976|Bacteroidetes,2FQ6S@200643|Bacteroidia 976|Bacteroidetes K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,HTH_18 k59_742745_1 1385517.N800_03155 1.69e-42 148.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1X3ZT@135614|Xanthomonadales 135614|Xanthomonadales C Heme copper-type cytochrome quinol oxidase subunit 3 cox3 - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_742745_2 1255043.TVNIR_3024 1.3e-29 112.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X0T0@135613|Chromatiales 135613|Chromatiales O PFAM Cytochrome c oxidase assembly protein CtaG Cox11 - - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_253679_1 760192.Halhy_0492 1.89e-52 185.0 COG3533@1|root,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes,1IPYH@117747|Sphingobacteriia 976|Bacteroidetes S Domain of unknown function - - - ko:K09955 - - - - ko00000 - - - DUF4986,Glyco_hydro_127 k59_123431_1 1088721.NSU_pLA2009 8.03e-17 81.3 COG0741@1|root,COG0741@2|Bacteria,1N00I@1224|Proteobacteria,2UFBZ@28211|Alphaproteobacteria,2K58I@204457|Sphingomonadales 204457|Sphingomonadales M Transglycosylase SLT domain virB1 - - ko:K03194 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 - - - SLT k59_907390_1 1235788.C802_03989 2.27e-84 256.0 COG0175@1|root,COG0175@2|Bacteria,4NEPD@976|Bacteroidetes,2FM2X@200643|Bacteroidia,4AKXN@815|Bacteroidaceae 976|Bacteroidetes H COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase cysD - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_776752_1 523791.Kkor_0209 1.59e-88 279.0 COG0471@1|root,COG0490@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1XHSW@135619|Oceanospirillales 135619|Oceanospirillales P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_841902_1 309807.SRU_1659 3.66e-35 133.0 COG3174@1|root,COG3174@2|Bacteria,4NKP6@976|Bacteroidetes,1FJWC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_614145_1 1492737.FEM08_04690 3.72e-148 429.0 COG2755@1|root,COG2755@2|Bacteria,4NKE5@976|Bacteroidetes,1IJUW@117743|Flavobacteriia,2P0NY@237|Flavobacterium 976|Bacteroidetes E pectate lyase - - - - - - - - - - - - Lipase_GDSL_2,Pec_lyase k59_614145_2 1235788.C802_03433 6.41e-26 107.0 COG1506@1|root,COG1506@2|Bacteria,4PMGM@976|Bacteroidetes,2FPGH@200643|Bacteroidia,4AKIG@815|Bacteroidaceae 976|Bacteroidetes E Abhydrolase family - - - - - - - - - - - - AXE1 k59_416600_1 1121405.dsmv_3403 2.52e-74 234.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2MHV9@213118|Desulfobacterales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_123432_1 177437.HRM2_26500 2.04e-103 333.0 COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria,2MHPX@213118|Desulfobacterales 28221|Deltaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity recC - 3.1.11.5 ko:K03583 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_V_gamma k59_517270_2 522306.CAP2UW1_3895 5.73e-53 172.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,2VHDT@28216|Betaproteobacteria 28216|Betaproteobacteria E phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_776758_1 10224.XP_002734431.2 3.29e-15 80.9 COG0515@1|root,KOG1095@2759|Eukaryota,38GM4@33154|Opisthokonta,3BCUM@33208|Metazoa,3CYSX@33213|Bilateria 33208|Metazoa T MAM and LDL-receptor class A domain-containing protein - - - - - - - - - - - - Ldl_recept_a,MAM k59_581139_1 1122918.KB907253_gene3309 2.47e-28 115.0 COG0667@1|root,COG0667@2|Bacteria,1UKPC@1239|Firmicutes,4HCF8@91061|Bacilli,27516@186822|Paenibacillaceae 91061|Bacilli C Aldo/keto reductase family tas - - - - - - - - - - - Aldo_ket_red k59_874354_1 926692.AZYG01000052_gene1820 5.73e-26 109.0 COG2182@1|root,COG2182@2|Bacteria,1TPU9@1239|Firmicutes,247KG@186801|Clostridia,3WAB7@53433|Halanaerobiales 186801|Clostridia G PFAM Bacterial extracellular solute-binding protein - - - ko:K15770 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - SBP_bac_8 k59_221875_1 1168034.FH5T_03150 7.79e-60 196.0 COG0285@1|root,COG0285@2|Bacteria,4NES8@976|Bacteroidetes,2FNFB@200643|Bacteroidia 976|Bacteroidetes H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_221875_2 1168034.FH5T_03155 6.31e-25 101.0 COG1875@1|root,COG1875@2|Bacteria,4NDUI@976|Bacteroidetes,2FP3H@200643|Bacteroidia 976|Bacteroidetes T ATPase related to phosphate starvation-inducible protein PhoH ybeZ_1 - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_416610_1 156889.Mmc1_1353 5.16e-68 233.0 COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1MVGH@1224|Proteobacteria,2U1X5@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_808741_1 96561.Dole_0554 3.28e-39 139.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales 28221|Deltaproteobacteria KLT PFAM Protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_8 k59_484514_1 1121405.dsmv_3101 1.31e-41 148.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2WJZM@28221|Deltaproteobacteria,2MHS9@213118|Desulfobacterales 28221|Deltaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_877232_1 1168034.FH5T_09975 9.79e-118 354.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - PMT_2 k59_745583_1 760568.Desku_0388 3.34e-32 122.0 COG2452@1|root,COG2452@2|Bacteria,1TQNJ@1239|Firmicutes,24B79@186801|Clostridia 186801|Clostridia L protein MJ0014 - Methanococcus jannaschii gi 1590824 gb AAB97992.1 (U67460) conserved - - - ko:K07450 - - - - ko00000 - - - MerR,MerR_1,Resolvase k59_844579_1 997829.HMPREF1121_00070 5.4e-12 64.7 COG0136@1|root,COG0136@2|Bacteria,4NE4V@976|Bacteroidetes,2FMHI@200643|Bacteroidia,22VZA@171551|Porphyromonadaceae 976|Bacteroidetes E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_844579_2 1408473.JHXO01000013_gene605 2.66e-140 410.0 COG0388@1|root,COG0388@2|Bacteria,4NEAQ@976|Bacteroidetes,2FNGK@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 ramA_2 - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_877234_1 485915.Dret_2370 1.44e-68 219.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42M4Y@68525|delta/epsilon subdivisions,2WKKD@28221|Deltaproteobacteria,2MG10@213115|Desulfovibrionales 28221|Deltaproteobacteria T metal-dependent phosphohydrolase HD region - - - ko:K07814 - - - - ko00000,ko02022 - - - HD_5,Response_reg k59_649601_1 936596.HMPREF1495_1974 2.2e-35 133.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,1HUVZ@1164882|Lachnoanaerobaculum 186801|Clostridia P FecCD transport family - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_649601_2 999411.HMPREF1092_03035 1.21e-86 266.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,36EEP@31979|Clostridiaceae 186801|Clostridia HP ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_649601_3 665571.STHERM_c21080 5.87e-47 169.0 COG0614@1|root,COG0614@2|Bacteria,2J7EM@203691|Spirochaetes 203691|Spirochaetes P periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_745584_1 1123399.AQVE01000004_gene2539 1.76e-36 139.0 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_617254_1 380358.XALC_0410 5.52e-41 155.0 COG0526@1|root,COG0526@2|Bacteria,1MWU8@1224|Proteobacteria,1SFUW@1236|Gammaproteobacteria,1X970@135614|Xanthomonadales 135614|Xanthomonadales M Protein of unknown function, DUF255 - - 5.3.4.1 ko:K01829 - - - - ko00000,ko01000 - - - Thioredoxin_7 k59_1041130_1 713586.KB900536_gene2702 3.94e-55 192.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1WWF7@135613|Chromatiales 135613|Chromatiales H TonB-dependent Receptor Plug - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_93491_1 158190.SpiGrapes_1871 3.07e-153 460.0 COG0495@1|root,COG0495@2|Bacteria,2J5BV@203691|Spirochaetes 203691|Spirochaetes J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_877236_2 743721.Psesu_2308 4.35e-34 129.0 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1X2YX@135614|Xanthomonadales 135614|Xanthomonadales E phospho-2-dehydro-3-deoxyheptonate aldolase dhs1 - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_2 k59_453358_1 1297742.A176_00092 4.56e-47 164.0 COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,431ET@68525|delta/epsilon subdivisions,2WWV2@28221|Deltaproteobacteria,2YX5R@29|Myxococcales 28221|Deltaproteobacteria S Saccharopine dehydrogenase NADP binding domain - - - - - - - - - - - - Sacchrp_dh_NADP k59_288159_1 1442598.JABW01000002_gene1771 1.15e-28 111.0 COG4185@1|root,COG4185@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Zeta_toxin k59_910956_1 1165841.SULAR_00590 1.56e-26 107.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2YMJ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mur ligase middle domain murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_910956_2 1165841.SULAR_00585 1.49e-52 171.0 COG0596@1|root,COG0596@2|Bacteria,1NH3R@1224|Proteobacteria,42R8Q@68525|delta/epsilon subdivisions,2YNWT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_93967_2 765914.ThisiDRAFT_1784 5.83e-24 97.4 COG3439@1|root,COG3439@2|Bacteria,1RA8I@1224|Proteobacteria,1S34D@1236|Gammaproteobacteria,1WXZJ@135613|Chromatiales 135613|Chromatiales S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_23768_1 713587.THITH_09035 2.15e-103 305.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1WW0K@135613|Chromatiales 135613|Chromatiales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_746253_1 1249480.B649_10270 1.13e-67 217.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2YMB7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_976347_1 4081.Solyc01g007640.2.1 5.55e-127 405.0 2CMQD@1|root,2QRDV@2759|Eukaryota,37QIN@33090|Viridiplantae,3GEA1@35493|Streptophyta,44PKI@71274|asterids 35493|Streptophyta C Plant protein of unknown function (DUF825) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009509,GO:0009532,GO:0009536,GO:0009570,GO:0009575,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 - - - - - - - - - - AAA,DUF825 k59_389671_1 870187.Thini_3264 7.56e-71 226.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,45ZYR@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_389671_2 1441629.PCH70_00710 2.18e-08 57.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,1S0UK@1236|Gammaproteobacteria,1Z5WK@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_715133_1 1504672.669787273 3.59e-69 214.0 COG3335@1|root,COG3335@2|Bacteria,1N5WI@1224|Proteobacteria,2VHUB@28216|Betaproteobacteria,4AF8S@80864|Comamonadaceae 28216|Betaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_193517_1 1537917.JU82_07765 7.34e-167 474.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2YMUN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_193517_3 563040.Saut_1524 2.39e-68 219.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2YMVM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_485194_1 1265502.KB905935_gene3039 1.25e-57 185.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,4AE7E@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the skp family ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_389685_1 519989.ECTPHS_06087 1.16e-73 237.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales 135613|Chromatiales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1041817_1 929558.SMGD1_1613 2.42e-114 333.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2YMIH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_553092_1 1127673.GLIP_1839 1.22e-101 310.0 COG3507@1|root,COG3507@2|Bacteria,1NNX4@1224|Proteobacteria,1RYTM@1236|Gammaproteobacteria,4657H@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 k59_93991_1 1144319.PMI16_04697 2.57e-88 269.0 COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2VWUY@28216|Betaproteobacteria,477T5@75682|Oxalobacteraceae 28216|Betaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_356679_1 257313.BP1725 6.18e-48 169.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,3T29H@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_1009449_1 1385515.N791_09370 1.99e-39 147.0 COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1X5EV@135614|Xanthomonadales 135614|Xanthomonadales S membrane - - - - - - - - - - - - MMPL k59_746273_1 1168034.FH5T_12260 1.66e-89 284.0 COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,2FM7F@200643|Bacteroidia 976|Bacteroidetes C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_1009450_2 1255043.TVNIR_1889 3.89e-71 221.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_420117_1 96561.Dole_2397 4.9e-49 167.0 COG1102@1|root,COG1102@2|Bacteria,1RGPP@1224|Proteobacteria,42RZZ@68525|delta/epsilon subdivisions,2WNEB@28221|Deltaproteobacteria,2MK0E@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 k59_585118_2 598659.NAMH_0018 3.38e-54 184.0 COG1351@1|root,COG1351@2|Bacteria 2|Bacteria F thymidylate synthase (FAD) activity thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_485221_1 1168034.FH5T_14985 4.4e-76 237.0 COG2972@1|root,COG2972@2|Bacteria,4NK09@976|Bacteroidetes,2FNWE@200643|Bacteroidia 976|Bacteroidetes T Histidine kinase ypdA_4 - - - - - - - - - - - HATPase_c_5,His_kinase k59_585125_1 1313304.CALK_1464 2.6e-87 276.0 COG2804@1|root,COG2804@2|Bacteria 2|Bacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_976391_1 626887.J057_22885 1.46e-30 124.0 2AK27@1|root,31ARV@2|Bacteria,1NMHV@1224|Proteobacteria,1T1AB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_193550_2 926559.JoomaDRAFT_2381 2.76e-56 182.0 COG2608@1|root,COG2608@2|Bacteria,4NEDS@976|Bacteroidetes,1HYSS@117743|Flavobacteriia 976|Bacteroidetes P mercuric transport protein - - - - - - - - - - - - HMA,MerT k59_94015_1 10228.TriadP35141 4.53e-13 62.8 COG0074@1|root,KOG1255@2759|Eukaryota 2759|Eukaryota C succinate-CoA ligase (GDP-forming) activity - GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006104,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016020,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0031974,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 6.2.1.4,6.2.1.5 ko:K01899 ko00020,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R00432,R00727 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_94015_2 765911.Thivi_3357 2.6e-85 263.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1WW90@135613|Chromatiales 135613|Chromatiales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_288757_1 1304275.C41B8_10930 1.81e-78 240.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_161400_1 326298.Suden_1047 2.74e-45 162.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2YMT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_161400_2 929558.SMGD1_2648 4.01e-18 82.4 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,42MPA@68525|delta/epsilon subdivisions,2YMKT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_976392_1 1355368.JART01000025_gene180 3e-39 142.0 COG0799@1|root,COG1057@1|root,COG0799@2|Bacteria,COG1057@2|Bacteria,1NG4J@1224|Proteobacteria,42P0F@68525|delta/epsilon subdivisions,2YMQR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like,RsfS k59_976392_2 1537917.JU82_10985 6.81e-51 163.0 COG0799@1|root,COG0799@2|Bacteria,1RCJN@1224|Proteobacteria,42TWB@68525|delta/epsilon subdivisions,2YPU4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_389717_1 1415779.JOMH01000001_gene2885 4.73e-43 157.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1X57M@135614|Xanthomonadales 135614|Xanthomonadales E Sodium alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_520918_1 177437.HRM2_01330 4.27e-06 45.4 COG0610@1|root,COG0610@2|Bacteria 2|Bacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_520918_2 331678.Cphamn1_2542 2.95e-78 239.0 COG1451@1|root,COG1451@2|Bacteria 2|Bacteria S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_1041860_1 1168034.FH5T_01510 8.39e-188 560.0 COG0577@1|root,COG0577@2|Bacteria,4NZYZ@976|Bacteroidetes,2FWFC@200643|Bacteroidia 976|Bacteroidetes V FtsX-like permease family - - - - - - - - - - - - FtsX k59_356713_1 572544.Ilyop_0201 3.76e-109 320.0 COG0356@1|root,COG0356@2|Bacteria,378C0@32066|Fusobacteria 32066|Fusobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_520928_1 485917.Phep_1526 1.16e-12 73.6 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1IQHK@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase pgtB - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA k59_59792_1 1408437.JNJN01000003_gene1562 2.24e-16 85.5 COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,25VDR@186806|Eubacteriaceae 186801|Clostridia L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_225774_1 1047013.AQSP01000107_gene2079 5.85e-35 125.0 COG1432@1|root,COG1432@2|Bacteria,2NRX6@2323|unclassified Bacteria 2|Bacteria S NYN domain - - - - - - - - - - - - NYN k59_225774_2 1240349.ANGC01000012_gene437 4.3e-19 80.9 COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4G24W@85025|Nocardiaceae 201174|Actinobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_225774_3 882378.RBRH_01624 1.23e-46 157.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,1K071@119060|Burkholderiaceae 28216|Betaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_126926_1 537970.HCAN_0190 5.82e-11 66.6 2ENNZ@1|root,33GAB@2|Bacteria,1R0T9@1224|Proteobacteria,43EFQ@68525|delta/epsilon subdivisions,2YTFA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_321323_1 690850.Desaf_3501 3.51e-23 105.0 COG3210@1|root,COG4412@1|root,COG3210@2|Bacteria,COG4412@2|Bacteria,1R3SG@1224|Proteobacteria,42SZZ@68525|delta/epsilon subdivisions,2WPD0@28221|Deltaproteobacteria,2MEAM@213115|Desulfovibrionales 28221|Deltaproteobacteria M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PA,Peptidase_M36,REJ k59_585172_1 713586.KB900536_gene37 2.66e-74 252.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria 1224|Proteobacteria L double-strand break repair protein AddB addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_809430_2 42565.FP66_10600 9.06e-72 221.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1XJ7F@135619|Oceanospirillales 135619|Oceanospirillales L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_257458_1 1168034.FH5T_12225 4.62e-154 438.0 COG1052@1|root,COG1052@2|Bacteria,4NFDE@976|Bacteroidetes,2FP6R@200643|Bacteroidia 976|Bacteroidetes CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_553141_1 187272.Mlg_1894 3.86e-53 180.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales 135613|Chromatiales C PFAM FAD linked oxidase domain protein - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_553141_2 1278309.KB907100_gene2191 4.92e-33 125.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,1XHN3@135619|Oceanospirillales 135619|Oceanospirillales C FAD binding domain glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_454263_1 1278309.KB907099_gene2593 1.5e-39 135.0 COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria,1S8J5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Domain of unknown function (DUF1924) shp - - - - - - - - - - - DUF1924 k59_454263_2 1122201.AUAZ01000005_gene606 4.18e-11 63.9 COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,1S2S2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Di-haem cytochrome c - - - - - - - - - - - - DHC k59_845244_1 264730.PSPPH_2620 3.97e-41 152.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1Z635@136849|Pseudomonas syringae group 1236|Gammaproteobacteria H B12 binding domain metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_845244_2 1528106.JRJE01000009_gene1834 4.51e-20 87.8 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2JQ95@204441|Rhodospirillales 204441|Rhodospirillales E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_161439_2 768671.ThimaDRAFT_3829 5.08e-54 182.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WXET@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_8,RnfC_N,SLBB k59_356746_1 1123326.JFBL01000008_gene391 1.56e-53 183.0 COG1070@1|root,COG1070@2|Bacteria,1MWS5@1224|Proteobacteria,43CSA@68525|delta/epsilon subdivisions,2YNV8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G COG1070 Sugar (pentulose and hexulose) - - 2.7.1.189 ko:K11216 ko02024,map02024 - R11183 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_650216_1 1165841.SULAR_07995 9.12e-58 181.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2YNWG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_1009502_1 1408422.JHYF01000011_gene3385 7.82e-72 233.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,36DHZ@31979|Clostridiaceae 186801|Clostridia F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS04230 AICARFT_IMPCHas,MGS k59_520946_1 207559.Dde_3427 3.31e-219 613.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2M8V9@213115|Desulfovibrionales 28221|Deltaproteobacteria V PFAM N-6 DNA methylase hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_520946_2 880072.Desac_0075 6.58e-76 259.0 COG0286@1|root,COG0732@1|root,COG0286@2|Bacteria,COG0732@2|Bacteria,1MW3A@1224|Proteobacteria,42M3B@68525|delta/epsilon subdivisions,2X2AD@28221|Deltaproteobacteria,2MR4B@213462|Syntrophobacterales 28221|Deltaproteobacteria L HsdM N-terminal domain - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_257465_1 626887.J057_22690 3.26e-68 226.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,4658U@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG3267 Type II secretory pathway, component ExeA gspA - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_976448_1 1165841.SULAR_07540 9.31e-54 175.0 COG1183@1|root,COG1183@2|Bacteria,1MYK9@1224|Proteobacteria,42RFD@68525|delta/epsilon subdivisions,2YP9Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_6486_1 1121405.dsmv_2390 2.18e-133 385.0 COG3385@1|root,COG3385@2|Bacteria,1R8CS@1224|Proteobacteria,42P9F@68525|delta/epsilon subdivisions,2WKTA@28221|Deltaproteobacteria,2MJAY@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_5,DDE_Tnp_2 k59_534088_1 1317122.ATO12_08470 7.06e-34 120.0 2CYW5@1|root,32T50@2|Bacteria,4NS73@976|Bacteroidetes,1I3WS@117743|Flavobacteriia,2YJE5@290174|Aquimarina 976|Bacteroidetes - - - - - - - - - - - - - - - k59_598903_1 317025.Tcr_1114 1.79e-14 71.6 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,460CZ@72273|Thiotrichales 72273|Thiotrichales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_598903_2 1168034.FH5T_12055 8.64e-34 126.0 28M15@1|root,2ZAG0@2|Bacteria,4NMZB@976|Bacteroidetes,2G2G6@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF4831) - - - - - - - - - - - - DUF4831 k59_434318_1 290512.Paes_1773 1.4e-29 114.0 2DQMF@1|root,337KW@2|Bacteria,1FESM@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - k59_631597_1 1156935.QWE_18839 3.25e-09 60.1 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,4BC46@82115|Rhizobiaceae 28211|Alphaproteobacteria C Domain of unknown function (DUF4445) nqrF - - - - - - - - - - - DUF4445,Fer2 k59_270732_1 387093.SUN_1891 8.95e-97 293.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2YMR4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_370215_1 420662.Mpe_A3368 7.26e-54 187.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,1KJHG@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_664669_1 933262.AXAM01000010_gene1385 1.93e-08 54.3 COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WR6T@28221|Deltaproteobacteria,2MK1E@213118|Desulfobacterales 28221|Deltaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_664669_2 933262.AXAM01000010_gene1386 2.41e-52 171.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MJKI@213118|Desulfobacterales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_991249_1 1168034.FH5T_02930 2.94e-56 180.0 COG0350@1|root,COG0350@2|Bacteria,4NFYC@976|Bacteroidetes,2FSA5@200643|Bacteroidia 976|Bacteroidetes H Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_926105_1 1537915.JU57_10190 1.11e-102 304.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2YNAJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_501332_1 765869.BDW_08065 1.51e-148 438.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2MTSI@213481|Bdellovibrionales,2WKBU@28221|Deltaproteobacteria 213481|Bdellovibrionales E extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_174193_1 396588.Tgr7_3002 1.32e-14 73.9 COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,1SKBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_174193_2 2340.JV46_24540 3.36e-22 94.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1J4ZG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - iJN746.PP_0110 UbiA k59_468128_2 395493.BegalDRAFT_2233 3.26e-81 267.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria 1236|Gammaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_75981_1 179408.Osc7112_5583 7.02e-20 96.7 COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria,1H8BN@1150|Oscillatoriales 1117|Cyanobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_598919_1 639283.Snov_1178 1.22e-12 69.7 COG1457@1|root,COG4191@1|root,COG1457@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TY1S@28211|Alphaproteobacteria,3EYQR@335928|Xanthobacteraceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_892573_1 1318628.MARLIPOL_03675 2.69e-76 246.0 COG0546@1|root,COG0546@2|Bacteria,1Q5AX@1224|Proteobacteria,1RRNJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phosphatases dhlA - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_859524_1 999141.GME_03367 7.87e-22 86.7 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,1XKET@135619|Oceanospirillales 135619|Oceanospirillales J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_859524_2 1049564.TevJSym_bl00190 9.73e-35 130.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1J4RK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_142031_1 1049564.TevJSym_aa02290 7.77e-67 226.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_1023091_1 1249975.JQLP01000005_gene2723 1.06e-34 131.0 2DQKA@1|root,337EA@2|Bacteria,4NY84@976|Bacteroidetes 976|Bacteroidetes S Uracil DNA glycosylase superfamily - - - - - - - - - - - - - k59_598922_1 886379.AEWI01000024_gene340 2.2e-18 88.6 COG0452@1|root,COG0452@2|Bacteria,4NE46@976|Bacteroidetes,2FNDG@200643|Bacteroidia,3XJ8W@558415|Marinilabiliaceae 976|Bacteroidetes H Flavoprotein coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_402158_2 484770.UFO1_4669 1.16e-74 232.0 COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,4H33H@909932|Negativicutes 909932|Negativicutes I PFAM 6-phosphogluconate dehydrogenase NAD-binding protein garR - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_827323_1 198628.Dda3937_03716 8.52e-71 233.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,2JD3E@204037|Dickeya 1236|Gammaproteobacteria L SMART helicase c2 yoaA GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_957763_1 1215343.B488_05230 4.88e-18 89.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,4B92R@82115|Rhizobiaceae 28211|Alphaproteobacteria T Histidine kinase pleC - 2.7.13.3 ko:K07716 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_3,PAS_7 k59_991250_1 1499967.BAYZ01000195_gene3087 1.8e-107 332.0 COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria 2|Bacteria O smart pdz dhr glgf htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_991250_2 469618.FVAG_01248 4.95e-174 526.0 COG0729@1|root,COG1752@1|root,COG0729@2|Bacteria,COG1752@2|Bacteria,378P1@32066|Fusobacteria 32066|Fusobacteria M Psort location OuterMembrane, score - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_728715_1 221359.RS9916_36052 2.16e-26 114.0 COG4872@1|root,COG4872@2|Bacteria 2|Bacteria S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157,GDYXXLXY k59_434342_1 411476.BACOVA_02021 9.52e-164 470.0 COG0499@1|root,COG0499@2|Bacteria,4NEKE@976|Bacteroidetes,2FPWZ@200643|Bacteroidia,4AP1W@815|Bacteroidaceae 976|Bacteroidetes H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_598938_1 221109.22778285 1.16e-10 66.6 COG0561@1|root,COG0561@2|Bacteria,1UFDJ@1239|Firmicutes,4HDIH@91061|Bacilli,23NBW@182709|Oceanobacillus 91061|Bacilli S Sucrose-6F-phosphate phosphohydrolase hmpP2 - - - - - - - - - - - Hydrolase_3 k59_892591_1 398525.KB900701_gene6815 3.38e-13 68.9 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,3JS8R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S biosynthesis protein E pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_892591_2 744980.TRICHSKD4_1623 1.99e-31 114.0 COG0535@1|root,COG0535@2|Bacteria,1N7TR@1224|Proteobacteria,2UFAS@28211|Alphaproteobacteria 28211|Alphaproteobacteria S coenzyme PQQ synthesis pqqD - - ko:K06138 - - - - ko00000 - - - PqqD k59_892591_3 78245.Xaut_1801 3.25e-11 63.2 COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2TSQT@28211|Alphaproteobacteria,3EXY8@335928|Xanthobacteraceae 28211|Alphaproteobacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ pqqC - 1.3.3.11 ko:K06136,ko:K06137 - - - - ko00000,ko01000 - - - TENA_THI-4 k59_402172_1 1239962.C943_02261 2.39e-32 124.0 COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes,47MXY@768503|Cytophagia 976|Bacteroidetes V Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase,DUF3471 k59_402172_2 1168034.FH5T_16815 5.57e-96 283.0 COG1238@1|root,COG1238@2|Bacteria,4NMW6@976|Bacteroidetes 976|Bacteroidetes I metal cluster binding - - - - - - - - - - - - SNARE_assoc k59_501363_1 768671.ThimaDRAFT_2919 5.33e-29 110.0 2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - - - - - - - - - - Cas6 k59_501363_2 1123399.AQVE01000001_gene504 1.19e-21 87.0 COG2920@1|root,COG2920@2|Bacteria,1RISY@1224|Proteobacteria,1S8HB@1236|Gammaproteobacteria 1236|Gammaproteobacteria P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_534127_2 563040.Saut_1368 7.98e-146 419.0 COG1565@1|root,COG1565@2|Bacteria,1QNDB@1224|Proteobacteria,42MQ8@68525|delta/epsilon subdivisions,2YNBU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_728722_1 981336.F944_00131 4.94e-12 62.4 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,3NN5W@468|Moraxellaceae 1236|Gammaproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_728722_2 713586.KB900536_gene1162 4.21e-19 79.7 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_728722_3 395493.BegalDRAFT_2615 3.75e-36 124.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,4613R@72273|Thiotrichales 72273|Thiotrichales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_859545_1 292415.Tbd_0830 2.52e-19 85.5 COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,2VUGI@28216|Betaproteobacteria 28216|Betaproteobacteria S Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - - - ko:K13053,ko:K14160 - - - - ko00000,ko03036,ko03400 - - - SulA k59_859545_2 390235.PputW619_1659 1.09e-36 129.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,1YYH8@136845|Pseudomonas putida group 1236|Gammaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_631632_1 709032.Sulku_1905 2.31e-101 309.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,42N4Y@68525|delta/epsilon subdivisions,2YNCE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - DinB_2,FGE-sulfatase,Methyltransf_11,Methyltransf_31 k59_696535_1 572544.Ilyop_1262 4.11e-113 337.0 COG0305@1|root,COG0305@2|Bacteria,3784X@32066|Fusobacteria 32066|Fusobacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_696535_2 469618.FVAG_01695 3.79e-220 615.0 COG0826@1|root,COG0826@2|Bacteria,378DV@32066|Fusobacteria 32066|Fusobacteria O Peptidase U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_534130_1 1168034.FH5T_00790 1.26e-87 285.0 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_239017_1 221988.MS0087 9.05e-24 105.0 COG5283@1|root,COG5283@2|Bacteria,1NFKU@1224|Proteobacteria,1RP2D@1236|Gammaproteobacteria,1Y7M1@135625|Pasteurellales 135625|Pasteurellales S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_142064_1 933262.AXAM01000127_gene1030 3.79e-23 95.1 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,2MKAW@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM Transglycosylase SLT domain - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - DUF4124,SLT k59_338221_1 368407.Memar_1880 1.27e-69 222.0 COG0725@1|root,arCOG00219@2157|Archaea,2XUPB@28890|Euryarchaeota 28890|Euryarchaeota P ABC-type molybdate transport system periplasmic component wtpA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0071944 - ko:K15495 ko02010,map02010 M00423 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.5 - - SBP_bac_11 k59_534134_1 255470.cbdbA109 1.29e-51 195.0 COG0326@1|root,COG0326@2|Bacteria,2G9ND@200795|Chloroflexi 200795|Chloroflexi O Molecular chaperone. Has ATPase activity - - - - - - - - - - - - - k59_534134_2 314230.DSM3645_14500 1.47e-41 154.0 COG0507@1|root,COG0507@2|Bacteria,2IZXV@203682|Planctomycetes 203682|Planctomycetes L Viral (Superfamily 1) RNA helicase - - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,UvrD_C_2 k59_338225_1 1122951.ATUE01000006_gene1119 1.36e-121 358.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,3NIF2@468|Moraxellaceae 1236|Gammaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919 NadA k59_827358_1 1417296.U879_11275 3.02e-133 388.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria 28211|Alphaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_76029_1 1238182.C882_1252 2.53e-46 162.0 COG4782@1|root,COG4782@2|Bacteria,1MXVC@1224|Proteobacteria,2V79W@28211|Alphaproteobacteria,2JSIV@204441|Rhodospirillales 204441|Rhodospirillales S Alpha/beta hydrolase of unknown function (DUF900) - - - - - - - - - - - - DUF900 k59_696552_1 1249627.D779_1266 1.09e-27 103.0 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales 135613|Chromatiales S RNA-binding protein - - - - - - - - - - - - RRM_1 k59_598967_1 933262.AXAM01000022_gene3241 6.59e-80 265.0 COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales 28221|Deltaproteobacteria IQ TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA - - - - - - - - - - - - Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_631659_1 1457250.BBMO01000001_gene1503 7.48e-33 133.0 COG0367@1|root,arCOG00071@2157|Archaea,2XV5E@28890|Euryarchaeota,23WDA@183963|Halobacteria 183963|Halobacteria E COG0367 Asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_142087_1 765912.Thimo_2264 2.44e-113 343.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales 135613|Chromatiales F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_991302_1 1499967.BAYZ01000044_gene3001 1.49e-52 179.0 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - OprD,Porin_4 k59_239052_1 521674.Plim_1494 2.17e-80 249.0 COG1305@1|root,COG1305@2|Bacteria,2IYAD@203682|Planctomycetes 203682|Planctomycetes E transglutaminase-like - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_859582_1 1283300.ATXB01000001_gene319 4.12e-165 482.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1XEDM@135618|Methylococcales 135618|Methylococcales C Aconitase C-terminal domain - - - - - - - - - - - - Aconitase,Aconitase_C k59_792722_1 517418.Ctha_0720 1.51e-38 131.0 COG2119@1|root,COG2119@2|Bacteria,1FFN7@1090|Chlorobi 1090|Chlorobi S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_41581_1 1168034.FH5T_05130 8.25e-70 221.0 COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,2FNG4@200643|Bacteroidia 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Acetyltransf_1 k59_41581_2 1168034.FH5T_05125 4.05e-19 85.1 COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,2FNG4@200643|Bacteroidia 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Acetyltransf_1 k59_566434_1 933262.AXAM01000060_gene2890 2.81e-99 299.0 COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42NJU@68525|delta/epsilon subdivisions,2WKA6@28221|Deltaproteobacteria,2MJK5@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4143) - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_1023162_1 382464.ABSI01000011_gene2872 7.23e-76 238.0 COG0563@1|root,COG0563@2|Bacteria,46YYW@74201|Verrucomicrobia,2IUVY@203494|Verrucomicrobiae 203494|Verrucomicrobiae F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK k59_728768_1 519989.ECTPHS_07242 1.81e-93 287.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales 135613|Chromatiales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_303977_2 997884.HMPREF1068_00494 3.22e-16 79.3 COG0463@1|root,COG0463@2|Bacteria,4PN4G@976|Bacteroidetes,2G0PY@200643|Bacteroidia 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_468588_1 272942.RCAP_rcc02299 5.88e-54 169.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,1FC28@1060|Rhodobacter 28211|Alphaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_502022_1 1182590.BN5_00877 2.13e-07 53.1 COG4221@1|root,COG4221@2|Bacteria,1R08K@1224|Proteobacteria 1224|Proteobacteria S KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_502022_2 1317124.DW2_04084 1.79e-64 207.0 COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,2U1A9@28211|Alphaproteobacteria,2XMIF@285107|Thioclava 28211|Alphaproteobacteria GM NAD(P)H-binding - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_207365_1 1172190.M947_10035 1.08e-20 90.5 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42M87@68525|delta/epsilon subdivisions,2YNA4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_207365_2 1249480.B649_09430 1.65e-14 71.6 COG0745@1|root,COG0745@2|Bacteria,1PGAE@1224|Proteobacteria,4348Y@68525|delta/epsilon subdivisions,2YREY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C k59_338863_1 1217718.ALOU01000112_gene4316 9.11e-92 280.0 COG1075@1|root,COG1075@2|Bacteria,1NSK3@1224|Proteobacteria,2WG1G@28216|Betaproteobacteria,1KI8H@119060|Burkholderiaceae 28216|Betaproteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_860174_1 1123274.KB899406_gene1038 1.81e-08 61.6 COG1080@1|root,COG1080@2|Bacteria,2J5FB@203691|Spirochaetes 203691|Spirochaetes G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_239589_1 1225785.CM001983_gene2677 4.49e-37 129.0 COG0454@1|root,COG0454@2|Bacteria,1QWFR@1224|Proteobacteria,1S6VC@1236|Gammaproteobacteria,2JE34@204037|Dickeya 1236|Gammaproteobacteria K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 k59_926748_1 1165841.SULAR_09554 3.04e-92 282.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2YMQM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_76548_1 1382306.JNIM01000001_gene2836 2.81e-75 256.0 COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi 200795|Chloroflexi L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_958359_1 472759.Nhal_3891 1.96e-98 297.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1WXGR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus assembly protein PilM - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_929462_2 768671.ThimaDRAFT_0873 1.13e-61 206.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales 135613|Chromatiales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_306835_1 1128421.JAGA01000002_gene717 2.48e-94 298.0 COG0201@1|root,COG0201@2|Bacteria,2NNVK@2323|unclassified Bacteria 2|Bacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_306835_2 204536.SULAZ_1736 3.46e-17 80.5 COG0200@1|root,COG0200@2|Bacteria,2G41V@200783|Aquificae 200783|Aquificae J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_306835_3 402777.KB235904_gene4616 8.74e-35 127.0 COG0098@1|root,COG0098@2|Bacteria,1G1EF@1117|Cyanobacteria,1H7SH@1150|Oscillatoriales 1117|Cyanobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rps5 GO:0003674,GO:0003735,GO:0005198,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_602535_1 1049564.TevJSym_av00040 2.41e-148 435.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1J5H2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon k59_765017_1 1035839.AFNK01000071_gene681 2.09e-79 251.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1Y6QU@135625|Pasteurellales 135625|Pasteurellales O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - ATPase,ChlI k59_635127_1 521011.Mpal_1912 4.69e-78 265.0 COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2NAA0@224756|Methanomicrobia 224756|Methanomicrobia P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_896275_1 977880.pRALTA_0394 0.000332 43.1 COG1484@1|root,COG3316@1|root,COG4584@1|root,COG1484@2|Bacteria,COG3316@2|Bacteria,COG4584@2|Bacteria,1RHKZ@1224|Proteobacteria,2WGG1@28216|Betaproteobacteria,1K2RM@119060|Burkholderiaceae 28216|Betaproteobacteria L transposase - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_896275_2 743299.Acife_2313 1.1e-40 152.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1SWPK@1236|Gammaproteobacteria,2NDCF@225057|Acidithiobacillales 225057|Acidithiobacillales L Integrase core domain - - - - - - - - - - - - rve k59_341708_2 402881.Plav_0316 1.24e-43 149.0 2E0TH@1|root,32WB5@2|Bacteria,1N3GK@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_242121_1 1123392.AQWL01000005_gene3146 6.92e-41 159.0 COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,2VK9C@28216|Betaproteobacteria 28216|Betaproteobacteria S Uncharacterised conserved protein (DUF2156) - - 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 - - DUF2156,LPG_synthase_TM k59_537444_1 749222.Nitsa_0340 2.26e-37 146.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,43AER@68525|delta/epsilon subdivisions,2YR8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M TIGRFAM YD repeat protein - - - - - - - - - - - - RHS_repeat k59_405424_1 1298867.AUES01000051_gene4511 6.69e-44 163.0 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_78876_2 572544.Ilyop_1839 2.59e-197 553.0 COG1077@1|root,COG1077@2|Bacteria,37873@32066|Fusobacteria 32066|Fusobacteria D cell shape determining protein, MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_78876_3 572544.Ilyop_1838 5.4e-53 176.0 COG2812@1|root,COG2812@2|Bacteria,37CVH@32066|Fusobacteria 32066|Fusobacteria L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_306851_1 4555.Si020892m 2.67e-09 54.7 2CQZ8@1|root,2R6BA@2759|Eukaryota,3871I@33090|Viridiplantae,3GZTC@35493|Streptophyta,3M958@4447|Liliopsida,3IT33@38820|Poales 35493|Streptophyta - - - - - - - - - - - - - - - k59_306851_2 3880.AES69829 1.9e-158 468.0 COG0048@1|root,COG0049@1|root,COG1007@1|root,KOG1750@2759|Eukaryota,KOG3291@2759|Eukaryota,KOG4668@2759|Eukaryota,37KVW@33090|Viridiplantae,3GH1R@35493|Streptophyta,4JNJF@91835|fabids 35493|Streptophyta C NAD(P)H-quinone oxidoreductase subunit 2 ndhB - 1.6.5.3 ko:K02992,ko:K05573 ko00190,ko01100,ko03010,map00190,map01100,map03010 M00145,M00178,M00179 R11945 RC00061 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - Proton_antipo_M k59_505226_1 1049564.TevJSym_ad00300 1.85e-105 318.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J90E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Proton-conducting membrane transporter - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_961357_2 1365176.N186_08995 2.9e-12 70.5 COG4690@1|root,arCOG03602@2157|Archaea,2XRTU@28889|Crenarchaeota 28889|Crenarchaeota E Peptidase family C69 - - - - - - - - - - - - Peptidase_C69 k59_505228_2 1191460.F959_00190 3.87e-26 104.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,3NN5T@468|Moraxellaceae 1236|Gammaproteobacteria U general secretion pathway protein gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_765037_1 1123008.KB905695_gene2541 2.11e-18 85.5 COG0502@1|root,COG0502@2|Bacteria,4NI8V@976|Bacteroidetes,2FQC9@200643|Bacteroidia,22XN4@171551|Porphyromonadaceae 976|Bacteroidetes C Biotin synthase hydE - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_765037_2 443254.Marpi_0104 2.1e-72 231.0 COG0502@1|root,COG0502@2|Bacteria,2GCAT@200918|Thermotogae 200918|Thermotogae C Biotin and Thiamin Synthesis associated thiH - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - iLJ478.TM1267 BATS,Radical_SAM k59_994613_1 1286106.MPL1_06300 1.11e-91 289.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,45ZMF@72273|Thiotrichales 72273|Thiotrichales CP Proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_437615_1 1304275.C41B8_02282 1.24e-39 137.0 COG1961@1|root,COG1961@2|Bacteria,1R3XB@1224|Proteobacteria,1RSC2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Resolvase - - - - - - - - - - - - HTH_7,Resolvase k59_765040_1 880073.Calab_2410 5.77e-12 71.2 COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria 2|Bacteria T Signal transduction histidine kinase, nitrogen specific, NtrB - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg k59_896304_1 827.JFJK01000009_gene1378 1.74e-69 211.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,42RDQ@68525|delta/epsilon subdivisions,2YP65@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_242142_1 357808.RoseRS_2562 1.39e-65 216.0 COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia 32061|Chloroflexia G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_994618_1 360106.CFF8240_1370 1.33e-14 73.6 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2YMKA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_273542_1 765910.MARPU_06485 8.19e-34 125.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1WXAS@135613|Chromatiales 135613|Chromatiales C PFAM NADH Ubiquinone - - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_273542_2 631362.Thi970DRAFT_00630 6.88e-39 137.0 2DNYF@1|root,32ZSU@2|Bacteria,1N8ZB@1224|Proteobacteria,1S5ZH@1236|Gammaproteobacteria,1WYS0@135613|Chromatiales 135613|Chromatiales S PFAM HupH hydrogenase expression protein, C-terminal conserved region - - - ko:K03618 - - - - ko00000 - - - HupH_C k59_862779_1 7213.XP_004532914.1 5.58e-212 625.0 COG0646@1|root,KOG1579@2759|Eukaryota,38H40@33154|Opisthokonta,3BHBF@33208|Metazoa,3CTDE@33213|Bilateria,41UWJ@6656|Arthropoda,3SQNC@50557|Insecta 33208|Metazoa E Homocysteine S-methyltransferase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_602570_1 1265503.KB905166_gene882 1.27e-16 79.7 COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,1RSIB@1236|Gammaproteobacteria,2Q827@267889|Colwelliaceae 1236|Gammaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_602570_2 269084.syc2302_d 6.04e-11 62.8 COG2133@1|root,COG2133@2|Bacteria,1G2QD@1117|Cyanobacteria,1GYDW@1129|Synechococcus 1117|Cyanobacteria G Glucose / Sorbosone dehydrogenase - - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH k59_569524_2 460265.Mnod_2315 1.01e-35 137.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JWZ9@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_8 k59_1026184_2 1049564.TevJSym_ar00470 7.76e-50 176.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1J4Z1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_765058_1 589865.DaAHT2_1598 1.14e-24 102.0 2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MKYF@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3786) - - - - - - - - - - - - DUF3786 k59_731593_1 525919.Apre_0060 3.33e-21 94.4 COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,22H8D@1570339|Peptoniphilaceae 186801|Clostridia C Glycerophosphodiester phosphodiesterase family protein glpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_210391_1 1158756.AQXQ01000012_gene1473 1.51e-67 219.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1WX7Y@135613|Chromatiales 135613|Chromatiales HJ Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - - - - - - - - - - ATP-grasp_3,RLAN,RimK k59_210391_2 1123392.AQWL01000003_gene249 2.17e-17 79.7 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,2WGQC@28216|Betaproteobacteria,1KRMT@119069|Hydrogenophilales 119069|Hydrogenophilales C Oxidoreductase FAD-binding domain - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_896330_1 439375.Oant_4260 3.56e-67 222.0 COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,2TRPY@28211|Alphaproteobacteria,1J1FM@118882|Brucellaceae 28211|Alphaproteobacteria E Oligopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_177946_1 990073.ATHU01000001_gene1786 1.79e-19 89.4 COG0454@1|root,COG4886@1|root,COG0456@2|Bacteria,COG4886@2|Bacteria,1Q94S@1224|Proteobacteria,42X59@68525|delta/epsilon subdivisions,2YQUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KLT COG4886 Leucine-rich repeat (LRR) protein - - - - - - - - - - - - LRR_4,LRR_8,Pkinase k59_177946_2 709032.Sulku_1503 2.01e-42 140.0 2A433@1|root,30SN2@2|Bacteria,1PBWY@1224|Proteobacteria,42VT4@68525|delta/epsilon subdivisions,2YQB2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_437649_1 1537917.JU82_10755 3.01e-105 313.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2YMQW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_961404_1 1347392.CCEZ01000044_gene672 4.88e-110 327.0 COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,36DKI@31979|Clostridiaceae 186801|Clostridia C Radical SAM - - - - - - - - - - - - Radical_SAM k59_273568_1 187272.Mlg_0956 8.98e-80 261.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales 135613|Chromatiales F PFAM glycosyl transferase family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_896335_1 511051.CSE_00940 1.06e-11 68.9 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_341766_1 575540.Isop_3379 1.04e-105 333.0 COG0553@1|root,COG0553@2|Bacteria,2IYGY@203682|Planctomycetes 203682|Planctomycetes L COGs COG0553 Superfamily II DNA RNA helicase SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_896551_28 400668.Mmwyl1_3004 1.42e-33 117.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1XKYU@135619|Oceanospirillales 135619|Oceanospirillales S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_896551_29 1049564.TevJSym_az00370 1.28e-118 348.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1J596@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type Mn2 Zn2 transport systems, permease znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_896551_30 1123399.AQVE01000001_gene706 4.02e-102 303.0 COG1121@1|root,COG1121@2|Bacteria,1MW47@1224|Proteobacteria,1RS5Y@1236|Gammaproteobacteria,4613H@72273|Thiotrichales 72273|Thiotrichales P ABC transporter - - - ko:K11710 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ABC_tran k59_896551_31 1265505.ATUG01000002_gene957 9.29e-69 223.0 COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WJYG@28221|Deltaproteobacteria,2MJBW@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_896551_32 1049564.TevJSym_as00540 2.31e-26 106.0 29QAQ@1|root,30B9W@2|Bacteria,1RGQ5@1224|Proteobacteria,1S5E4@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_896551_33 1123366.TH3_18168 4.13e-19 80.1 2EK1G@1|root,33DRY@2|Bacteria,1NH6C@1224|Proteobacteria,2UXGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3012) - - - - - - - - - - - - DUF3012 k59_896551_34 1124983.PFLCHA0_c00880 9.42e-53 198.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,1YMIJ@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T diguanylate cyclase pleD - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_896551_35 765912.Thimo_0445 3.63e-101 302.0 COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1RYBE@1236|Gammaproteobacteria,1X2D8@135613|Chromatiales 135613|Chromatiales L PFAM Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_896551_36 2340.JV46_05830 1e-43 152.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thiol disulfide interchange protein dsbA GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA k59_896551_37 1049564.TevJSym_as00580 7.64e-85 256.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1J6DD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2863 Cytochrome c553 cc4 - - - - - - - - - - - Cytochrom_C k59_896551_38 1049564.TevJSym_ac00160 6.31e-146 432.0 COG1169@1|root,COG1169@2|Bacteria,1MVB7@1224|Proteobacteria,1RNSR@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of chorismate to isochorismate menF GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008909,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009233,GO:0009234,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042180,GO:0042181,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046872,GO:0050486,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901661,GO:1901663,GO:1902494 5.4.4.2 ko:K01851,ko:K02361,ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c26010,iECIAI39_1322.ECIAI39_2413,iSF_1195.SF2344,iS_1188.S2478,ic_1306.c2809 Chorismate_bind k59_896551_39 1049564.TevJSym_ac00170 6.07e-223 635.0 COG1165@1|root,COG1165@2|Bacteria,1MVMZ@1224|Proteobacteria,1RNRS@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD GO:0003674,GO:0003824,GO:0005488,GO:0006732,GO:0008150,GO:0008152,GO:0008683,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016833,GO:0019842,GO:0030976,GO:0036094,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070204,GO:0071704,GO:0097159,GO:1901363,GO:1901576,GO:1901661,GO:1901663,GO:1901681 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_2301 TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_896551_40 566466.NOR53_2460 4.26e-140 460.0 COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1J56J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Small-conductance mechanosensitive channel kefA GO:0005575,GO:0005623,GO:0005886,GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016020,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0044464,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K05802,ko:K22051 - - - - ko00000,ko02000 1.A.23.1.1,1.A.23.1.2,1.A.23.1.3 - - MS_channel,MscS_TM,MscS_porin k59_896551_41 1049564.TevJSym_ac00190 5.88e-172 483.0 COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,1T1TZ@1236|Gammaproteobacteria,1JBZH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - iYL1228.KPN_02660 ECH_1 k59_896551_42 1049564.TevJSym_ac00200 4.4e-127 370.0 COG1575@1|root,COG1575@2|Bacteria,1PKCZ@1224|Proteobacteria,1SXAN@1236|Gammaproteobacteria,1J9HU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_896551_45 1122135.KB893141_gene66 5.61e-154 441.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,2U20B@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Mg2 transporter protein, CorA family protein - - - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_896551_48 765914.ThisiDRAFT_0751 8.14e-77 231.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1WYAE@135613|Chromatiales 135613|Chromatiales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_896551_49 1120970.AUBZ01000006_gene1110 5.56e-245 678.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,464FS@72275|Alteromonadaceae 1236|Gammaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB2 - 4.2.1.20 ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_896551_50 1163617.SCD_n00348 1.12e-90 283.0 COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2VH1R@28216|Betaproteobacteria 28216|Betaproteobacteria M mandelate racemase muconate lactonizing catB - 4.2.1.113,4.2.1.171,5.1.1.20,5.1.1.22,5.5.1.1,5.5.1.7 ko:K01856,ko:K01860,ko:K02549,ko:K19802,ko:K21617,ko:K21624 ko00130,ko00330,ko00361,ko00362,ko00364,ko00623,ko01100,ko01110,ko01120,ko01220,map00130,map00330,map00361,map00362,map00364,map00623,map01100,map01110,map01120,map01220 M00116,M00568 R04031,R04259,R05300,R05390,R05392,R06834,R06840,R06989,R08116,R08119,R09135,R09215,R09217,R09221,R09229,R10938,R11625 RC00903,RC01038,RC01053,RC01108,RC01321,RC01356,RC01358,RC01687,RC02117,RC02448,RC02464,RC02465,RC03309 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_896551_51 1049564.TevJSym_ae00490 2.72e-141 421.0 COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,1RN35@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ O-succinylbenzoic acid--CoA ligase menE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0008150,GO:0008152,GO:0008756,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016043,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0022607,GO:0042180,GO:0042181,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576,GO:1901661,GO:1901663 6.2.1.26 ko:K00666,ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004 - - iECNA114_1301.ECNA114_2354,iECSF_1327.ECSF_2141,iEcE24377_1341.EcE24377A_2556,iEcHS_1320.EcHS_A2406,iLF82_1304.LF82_1314,iNRG857_1313.NRG857_11465 AMP-binding,AMP-binding_C k59_896551_52 767434.Fraau_2915 2.37e-16 73.9 COG3831@1|root,COG3831@2|Bacteria,1NGUF@1224|Proteobacteria,1T9BG@1236|Gammaproteobacteria,1X84E@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - WGR k59_896551_53 765913.ThidrDRAFT_0111 6.13e-51 167.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1WYZ4@135613|Chromatiales 135613|Chromatiales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_896551_54 1049564.TevJSym_ad00800 9.28e-67 210.0 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,1S3NG@1236|Gammaproteobacteria,1JB67@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S SCO1/SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_896551_55 765913.ThidrDRAFT_1777 2.55e-46 155.0 2EQTE@1|root,33ID4@2|Bacteria,1RKB7@1224|Proteobacteria,1S6DN@1236|Gammaproteobacteria,1WYKP@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_896551_56 583345.Mmol_0398 7.47e-29 107.0 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KMZ0@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM cytochrome c, class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_896551_57 1049564.TevJSym_as00630 2.53e-70 217.0 COG2862@1|root,COG2862@2|Bacteria,1RFUX@1224|Proteobacteria,1S75J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein family, UPF0114 - - - - - - - - - - - - UPF0114 k59_896551_58 396588.Tgr7_0487 0.0 1051.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_896551_59 519989.ECTPHS_01624 7.11e-70 219.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,1WX4D@135613|Chromatiales 135613|Chromatiales O PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_896551_61 768671.ThimaDRAFT_3045 1.91e-158 460.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales 135613|Chromatiales M PFAM Three-deoxy-D-manno-octulosonic-acid transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N,Kdo k59_896551_62 757424.Hsero_4417 1.1e-71 222.0 COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,2WF6I@28216|Betaproteobacteria,477A3@75682|Oxalobacteraceae 28216|Betaproteobacteria G SIS domain - - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_896551_63 870187.Thini_3872 1.95e-92 280.0 COG0667@1|root,COG0667@2|Bacteria,1PDY4@1224|Proteobacteria,1RQYV@1236|Gammaproteobacteria,461PQ@72273|Thiotrichales 72273|Thiotrichales C PFAM Aldo keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_896551_64 247633.GP2143_16126 3.15e-106 325.0 COG0578@1|root,COG0578@2|Bacteria,1QXST@1224|Proteobacteria,1T3HY@1236|Gammaproteobacteria,1J5NK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0578 Glycerol-3-phosphate dehydrogenase - - - - - - - - - - - - DAO k59_443267_2 933262.AXAM01000003_gene2862 3.51e-32 123.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,42NYD@68525|delta/epsilon subdivisions,2WKHT@28221|Deltaproteobacteria,2MHU9@213118|Desulfobacterales 28221|Deltaproteobacteria S permease YjgP YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_312470_1 1224136.AMFN01000023_gene1894 2.06e-06 50.1 COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,1RQ41@1236|Gammaproteobacteria,283BU@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria S Haloacid dehalogenase-like hydrolase yigB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0022611,GO:0032502,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.102,3.1.3.104 ko:K20862 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00548,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD_2 k59_312470_2 1027273.GZ77_14680 9.7e-16 77.8 COG3977@1|root,COG3977@2|Bacteria,1MVRW@1224|Proteobacteria,1RNK1@1236|Gammaproteobacteria,1XHID@135619|Oceanospirillales 135619|Oceanospirillales E catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids avtA - - - - - - - - - - - Aminotran_1_2 k59_476354_1 929558.SMGD1_0622 6.62e-62 203.0 COG0845@1|root,COG0845@2|Bacteria,1RI9S@1224|Proteobacteria,42T1D@68525|delta/epsilon subdivisions,2YPK5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_278990_2 351348.Maqu_3418 1.69e-65 202.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,4679A@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_5014 PRA-CH,PRA-PH k59_278990_3 1469245.JFBG01000027_gene1458 5.81e-33 122.0 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1WYNT@135613|Chromatiales 135613|Chromatiales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_278990_4 1123517.JOMR01000001_gene3 1.28e-18 79.7 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,461D2@72273|Thiotrichales 72273|Thiotrichales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_184257_1 935948.KE386494_gene745 6.61e-149 432.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,42FX4@68295|Thermoanaerobacterales 186801|Clostridia G PFAM glycoside hydrolase, family 4 - - 3.2.1.22 ko:K07406 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_4,Glyco_hydro_4C k59_184257_2 996637.SGM_2866 5.73e-10 63.5 COG1172@1|root,COG1879@1|root,COG1172@2|Bacteria,COG1879@2|Bacteria,2GJDW@201174|Actinobacteria 201174|Actinobacteria G Belongs to the binding-protein-dependent transport system permease family rbsC - - ko:K10439,ko:K10440 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2,Peripla_BP_4 k59_216804_1 243159.AFE_0466 2.67e-71 228.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,2NCJG@225057|Acidithiobacillales 225057|Acidithiobacillales E Glutamine synthetase, catalytic domain glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_641468_1 349124.Hhal_2429 7.62e-45 150.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1WY0Q@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_85028_1 1123237.Salmuc_05264 1.39e-126 372.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U0EE@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_608854_1 1168034.FH5T_21975 4.88e-62 201.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA k59_184281_2 85643.Tmz1t_2956 9.34e-38 135.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,2KY5Y@206389|Rhodocyclales 206389|Rhodocyclales C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_14705_1 768066.HELO_2643 2.55e-40 144.0 28JC4@1|root,2Z96S@2|Bacteria,1RI8W@1224|Proteobacteria,1S6FI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S P22 coat protein-protein 5 domain protein - - - - - - - - - - - - - k59_869156_1 1511.CLOST_0457 1.8e-24 107.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,25QT4@186804|Peptostreptococcaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_85033_1 1304885.AUEY01000013_gene3078 2.45e-65 213.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,2MI0K@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_800789_1 583355.Caka_2618 2.22e-48 165.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_902256_1 1049564.TevJSym_aj00240 3.89e-87 268.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1J5BU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_216832_2 1525715.IX54_10770 1.93e-13 73.2 COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,2U0G2@28211|Alphaproteobacteria,2PXV3@265|Paracoccus 28211|Alphaproteobacteria K Bacterial transcriptional repressor C-terminal - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_348068_1 1168034.FH5T_18040 2.63e-70 226.0 COG3303@1|root,COG3303@2|Bacteria,4NG0P@976|Bacteroidetes,2FP37@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process nrfA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 k59_348068_2 1168034.FH5T_18045 2.55e-51 173.0 COG3203@1|root,COG3203@2|Bacteria,4NDYW@976|Bacteroidetes,2FMQD@200643|Bacteroidia 976|Bacteroidetes M Alginate export - - - - - - - - - - - - Alginate_exp k59_411782_1 1168034.FH5T_05205 4.59e-54 176.0 COG3439@1|root,COG3439@2|Bacteria,4PB0E@976|Bacteroidetes,2FY5F@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_411782_2 1410628.JNKS01000009_gene3226 1.35e-07 55.8 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,27IBQ@186928|unclassified Lachnospiraceae 186801|Clostridia P E1-E2 ATPase actP - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_411782_4 1168034.FH5T_10090 7.19e-12 64.3 COG0458@1|root,COG0458@2|Bacteria,4NEQ0@976|Bacteroidetes,2FMKD@200643|Bacteroidia 976|Bacteroidetes EF Carbamoyl-phosphate synthase (glutamine-hydrolyzing) carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_118152_2 1168034.FH5T_08380 8.75e-105 306.0 COG0127@1|root,COG0127@2|Bacteria,4NM42@976|Bacteroidetes,2FP46@200643|Bacteroidia 976|Bacteroidetes F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_443923_1 563040.Saut_2117 4.45e-116 343.0 COG2199@1|root,COG2199@2|Bacteria,1QZ2R@1224|Proteobacteria,43CET@68525|delta/epsilon subdivisions,2YTCA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF k59_641484_3 1121440.AUMA01000002_gene2167 6.98e-76 243.0 COG2885@1|root,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2M7W6@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the ompA family - - - - - - - - - - - - OmpA,TSP_3 k59_641484_4 1121935.AQXX01000112_gene5756 7.33e-53 172.0 COG2365@1|root,COG2365@2|Bacteria,1RGE7@1224|Proteobacteria,1SBQH@1236|Gammaproteobacteria,1XPA6@135619|Oceanospirillales 135619|Oceanospirillales T Tyrosine phosphatase family - - - - - - - - - - - - Y_phosphatase2 k59_443928_2 1283300.ATXB01000001_gene2335 2.9e-11 64.3 COG1216@1|root,COG2120@1|root,COG1216@2|Bacteria,COG2120@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,1XDIU@135618|Methylococcales 135618|Methylococcales H Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2,Methyltransf_24 k59_935427_1 316055.RPE_3197 7.99e-69 219.0 COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,2U1A9@28211|Alphaproteobacteria,3JXC0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Polysaccharide biosynthesis protein - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_706364_1 1049564.TevJSym_be00270 3.96e-215 615.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J57P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_869174_1 1125973.JNLC01000010_gene1601 1.45e-64 210.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,3JRVX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_216844_1 1049564.TevJSym_aa02180 4.31e-54 173.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1J5XT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_902285_1 345341.KUTG_09261 2.43e-46 168.0 COG3250@1|root,COG3250@2|Bacteria,2I9Q2@201174|Actinobacteria,4EAA4@85010|Pseudonocardiales 201174|Actinobacteria G Ricin-type beta-trefoil lectin domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,RicinB_lectin_2 k59_279684_2 867903.ThesuDRAFT_01285 3.28e-50 183.0 COG1203@1|root,COG1203@2|Bacteria,1TQ9B@1239|Firmicutes,248UE@186801|Clostridia,3WD49@538999|Clostridiales incertae sedis 186801|Clostridia L Metal dependent phosphohydrolases with conserved 'HD' motif. cas3 - - ko:K07012 - - - - ko00000,ko01000,ko02048 - - - DEAD,HD,Helicase_C,ResIII k59_379505_1 1304885.AUEY01000082_gene2154 4.56e-123 374.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42NEV@68525|delta/epsilon subdivisions,2WJD0@28221|Deltaproteobacteria,2MHX6@213118|Desulfobacterales 28221|Deltaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_348091_1 716544.wcw_1902 5.05e-120 357.0 COG3328@1|root,COG3328@2|Bacteria,2JGVA@204428|Chlamydiae 204428|Chlamydiae L Transposase and inactivated derivatives - - - - - - - - - - - - Transposase_mut k59_248537_2 1232437.KL662018_gene610 2.91e-24 97.4 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,42VCD@68525|delta/epsilon subdivisions,2WRUC@28221|Deltaproteobacteria,2MMEZ@213118|Desulfobacterales 28221|Deltaproteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32,rve k59_674629_1 1537917.JU82_00605 1.62e-98 296.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2YMBY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_50664_1 187272.Mlg_1842 0.000151 45.1 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales 135613|Chromatiales D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_50664_2 1123253.AUBD01000007_gene667 4.2e-41 145.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1X3I8@135614|Xanthomonadales 135614|Xanthomonadales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_443950_2 1165841.SULAR_03777 1.53e-27 112.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,42N8E@68525|delta/epsilon subdivisions,2YNF0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_511591_2 696369.KI912183_gene1480 3.93e-13 72.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,2603X@186807|Peptococcaceae 186801|Clostridia NU PFAM Type II secretion system protein E - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_967850_1 446469.Sked_09980 2.06e-36 125.0 COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria 201174|Actinobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_967850_2 1169152.AXVD01000005_gene440 5.52e-25 99.8 COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria,4FUSW@85025|Nocardiaceae 201174|Actinobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_118191_1 1537917.JU82_08445 1.03e-91 274.0 COG1309@1|root,COG1309@2|Bacteria,1RG05@1224|Proteobacteria,42RA4@68525|delta/epsilon subdivisions,2YNVU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - TetR_N k59_641515_1 383372.Rcas_1644 6.07e-05 48.1 COG0018@1|root,COG0018@2|Bacteria,2G6DK@200795|Chloroflexi,374S1@32061|Chloroflexia 32061|Chloroflexia J TIGRFAM arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_641515_2 1479623.JHEL01000015_gene505 7.34e-05 48.5 COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4FKTB@85023|Microbacteriaceae 201174|Actinobacteria L Involved in DNA repair and RecF pathway recombination recO GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_14739_1 702450.CUW_0097 5.93e-176 504.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,3VNUF@526524|Erysipelotrichia 526524|Erysipelotrichia G Psort location Cytoplasmic, score - - - - - - - - - - - - Alpha-amylase,Malt_amylase_C k59_313077_2 1165841.SULAR_00830 1.24e-125 366.0 COG0679@1|root,COG0679@2|Bacteria,1N5NC@1224|Proteobacteria,42PYE@68525|delta/epsilon subdivisions,2YMUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_313077_3 749222.Nitsa_1494 9.8e-111 329.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2YM99@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Saccharopine dehydrogenase LYS1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_543521_1 387092.NIS_0035 7.34e-33 117.0 COG2033@1|root,COG2033@2|Bacteria 2|Bacteria C superoxide reductase activity rbo - 1.15.1.2 ko:K05919,ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - Desulfoferrod_N,Desulfoferrodox,SoxZ k59_543521_2 156889.Mmc1_3716 3.58e-26 103.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2U72E@28211|Alphaproteobacteria 28211|Alphaproteobacteria S sulfur oxidation protein soxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_543521_3 1172190.M947_05425 1.22e-96 296.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42Q9B@68525|delta/epsilon subdivisions,2YNKN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - FCSD-flav_bind,Pyr_redox_2 k59_443961_1 944479.JQLX01000010_gene501 1.44e-27 115.0 COG0745@1|root,COG2200@1|root,COG0745@2|Bacteria,COG2200@2|Bacteria,1NQKX@1224|Proteobacteria,43AWS@68525|delta/epsilon subdivisions,2WUX5@28221|Deltaproteobacteria,2M6Z0@213113|Desulfurellales 28221|Deltaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,PAS_3,Response_reg k59_902322_1 1165841.SULAR_08107 1.8e-23 110.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind k59_118211_1 563040.Saut_0671 3.18e-134 392.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2YNUK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_737693_1 243233.MCA2870 4.53e-10 60.8 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XDNC@135618|Methylococcales 135618|Methylococcales EH synthase component I pabB - 2.6.1.85 ko:K01665 ko00790,map00790 - R01716 RC00010,RC01418 ko00000,ko00001,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_737693_2 232346.JHQL01000004_gene1777 7.73e-17 79.3 COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,1RR0H@1236|Gammaproteobacteria,1XJJP@135619|Oceanospirillales 135619|Oceanospirillales S Haloacid dehalogenase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_411819_1 1397528.Q671_09440 1.6e-23 100.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XHJR@135619|Oceanospirillales 135619|Oceanospirillales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_737698_1 105559.Nwat_0545 1.9e-91 277.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales 135613|Chromatiales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_85100_1 1278309.KB907103_gene1012 3.91e-30 120.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XITW@135619|Oceanospirillales 135619|Oceanospirillales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_771584_1 545243.BAEV01000031_gene467 7.64e-08 56.2 COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,36E1K@31979|Clostridiaceae 186801|Clostridia J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_771584_2 879212.DespoDRAFT_00402 1.33e-18 84.3 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2WK2M@28221|Deltaproteobacteria,2MJ27@213118|Desulfobacterales 28221|Deltaproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K02523,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_511629_1 1304885.AUEY01000073_gene1469 2.04e-57 186.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2MIV5@213118|Desulfobacterales 28221|Deltaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0547 Asp_Glu_race k59_800850_2 83406.HDN1F_00980 4.52e-36 130.0 COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,1RRUP@1236|Gammaproteobacteria,1J6NU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K beta-keto acid cleavage enzyme - - - - - - - - - - - - BKACE k59_14774_1 1165841.SULAR_00825 7.25e-120 351.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2YM99@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Saccharopine dehydrogenase LYS1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_902337_1 1278307.KB906980_gene4142 4.71e-72 247.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,2QIQN@267894|Psychromonadaceae 1236|Gammaproteobacteria P Cyclic nucleotide-monophosphate binding domain - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,cNMP_binding k59_902337_2 187272.Mlg_2501 1.44e-51 185.0 COG3203@1|root,COG3203@2|Bacteria,1MX4Q@1224|Proteobacteria,1RY5B@1236|Gammaproteobacteria,1X0SM@135613|Chromatiales 135613|Chromatiales M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_380233_1 563040.Saut_1302 1.66e-93 282.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2YMY3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O hydrogenase expression formation protein hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_412441_1 999141.GME_18927 3.59e-53 172.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1XJC5@135619|Oceanospirillales 135619|Oceanospirillales S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - - - - - - - - - - Hexapep k59_317969_1 1121875.KB907546_gene2203 6.39e-25 102.0 COG2367@1|root,COG2367@2|Bacteria,4NE3C@976|Bacteroidetes,1HZYJ@117743|Flavobacteriia 976|Bacteroidetes V beta-lactamase per1 - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_317969_2 1121875.KB907546_gene2207 1.07e-73 234.0 COG5476@1|root,COG5476@2|Bacteria,4NG23@976|Bacteroidetes,1I0K5@117743|Flavobacteriia 2|Bacteria S MlrC C-terminus - - - ko:K19048 - - - - ko00000,ko02048 - - - DUF1485,MlrC_C k59_776664_1 1249627.D779_1484 1.86e-05 46.2 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1WW0E@135613|Chromatiales 135613|Chromatiales G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_776664_2 926692.AZYG01000038_gene1057 3.39e-83 254.0 COG1023@1|root,COG1023@2|Bacteria,1UHN4@1239|Firmicutes,25E7N@186801|Clostridia,3WBIZ@53433|Halanaerobiales 186801|Clostridia G 6-phosphogluconate dehydrogenase, C-terminal domain gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_157188_1 1266925.JHVX01000020_gene1777 6.81e-19 87.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,371WH@32003|Nitrosomonadales 28216|Betaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_157188_2 2340.JV46_28910 2.99e-29 107.0 COG0607@1|root,COG0607@2|Bacteria,1QMXA@1224|Proteobacteria,1S6DI@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam Rhodanese-like - - - - - - - - - - - - Rhodanese k59_90584_1 1449126.JQKL01000035_gene2155 2.12e-36 140.0 COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia 186801|Clostridia O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_711490_1 929558.SMGD1_1929 5.4e-06 48.5 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2YP4X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L methyltransferase rsmD - - - - - - - - - - - Cons_hypoth95 k59_711490_2 387092.NIS_0996 1.16e-71 225.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2YMI2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - ko:K02034,ko:K12370 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_907324_1 326298.Suden_0769 3.37e-34 122.0 COG1714@1|root,COG1714@2|Bacteria 2|Bacteria S RDD family - - - - - - - - - - - - RDD k59_907324_2 1249480.B649_08150 1.35e-35 130.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2YMSV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E o-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_614085_1 709032.Sulku_2593 4.95e-167 477.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2YMKZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitric oxide reductase norZ - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_253611_1 690850.Desaf_0477 2.77e-40 148.0 COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria,42YC9@68525|delta/epsilon subdivisions,2WTSH@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Beta-lactamase - - - - - - - - - - - - - k59_449481_2 387093.SUN_0026 4.83e-17 85.1 2A9R8@1|root,30YYK@2|Bacteria,1PKV5@1224|Proteobacteria,42XYU@68525|delta/epsilon subdivisions,2YQWH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_317974_1 754477.Q7C_1988 6.23e-09 62.8 COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,1RRRC@1236|Gammaproteobacteria,460RI@72273|Thiotrichales 72273|Thiotrichales M OmpW family - - - ko:K07275 - - - - ko00000 - - - OmpW k59_679918_2 247634.GPB2148_3534 2.64e-36 129.0 COG5012@1|root,COG5012@2|Bacteria,1QDZ3@1224|Proteobacteria,1RYST@1236|Gammaproteobacteria,1J90C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S B12 binding domain - - - - - - - - - - - - B12-binding,B12-binding_2 k59_189507_1 640081.Dsui_2108 9.59e-86 280.0 COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,2VXDT@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase - - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,Helicase_C,Peptidase_C14 k59_384892_2 402881.Plav_2864 3.22e-15 73.6 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,2TSUP@28211|Alphaproteobacteria,1JNUW@119043|Rhodobiaceae 28211|Alphaproteobacteria L UreE urease accessory protein, C-terminal domain ung - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_157207_2 1123326.JFBL01000001_gene1328 3.57e-85 263.0 COG0426@1|root,COG0426@2|Bacteria,1NDXY@1224|Proteobacteria,42N11@68525|delta/epsilon subdivisions,2YNA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Metallo-beta-lactamase superfamily - - 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B k59_19763_1 1168034.FH5T_17705 1.29e-107 323.0 COG0519@1|root,COG0519@2|Bacteria,4NESX@976|Bacteroidetes,2FM3V@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_189514_1 749222.Nitsa_1243 4.83e-42 144.0 COG0500@1|root,COG2226@2|Bacteria,1RFJD@1224|Proteobacteria,42S09@68525|delta/epsilon subdivisions,2YPFV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - - k59_1037733_1 566466.NOR53_1154 1.8e-22 102.0 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,1J8IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_19767_1 931627.MycrhDRAFT_2509 7.13e-105 314.0 COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,233QZ@1762|Mycobacteriaceae 201174|Actinobacteria I acyl-CoA dehydrogenase fadE2 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_481706_1 768671.ThimaDRAFT_2348 1.31e-37 144.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales 135613|Chromatiales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_123378_1 439235.Dalk_2894 2.86e-39 149.0 COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,PAS,PAS_3,PAS_9,Response_reg k59_711515_1 1399774.JDWH01000013_gene695 7.25e-141 416.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,3X0GZ@547|Enterobacter 1236|Gammaproteobacteria T PrkA serine kinase yeaG GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_1037740_1 1499967.BAYZ01000018_gene6343 1.23e-19 88.6 COG0415@1|root,COG0415@2|Bacteria,2NQCC@2323|unclassified Bacteria 2|Bacteria L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1037740_2 933262.AXAM01000019_gene1119 6.73e-33 120.0 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,42TC0@68525|delta/epsilon subdivisions,2WPYI@28221|Deltaproteobacteria,2MK6A@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k59_317995_1 991.IW20_12455 1.51e-28 113.0 COG0253@1|root,COG0253@2|Bacteria,4NF26@976|Bacteroidetes,1HY3U@117743|Flavobacteriia,2NSDT@237|Flavobacterium 976|Bacteroidetes E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_646756_2 1168034.FH5T_02905 1.07e-26 109.0 COG1524@1|root,COG1524@2|Bacteria,4NE94@976|Bacteroidetes,2FMQC@200643|Bacteroidia 976|Bacteroidetes P type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_1005947_1 1165841.SULAR_06288 6.34e-128 375.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2YMBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1055 Na H antiporter NhaD and related arsenite - - - - - - - - - - - - CitMHS k59_679939_1 391165.GbCGDNIH1_0206 2.37e-102 307.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2JQ95@204441|Rhodospirillales 204441|Rhodospirillales E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_481714_1 880073.Calab_0834 8.48e-16 82.0 COG3385@1|root,COG3385@2|Bacteria,2NRDU@2323|unclassified Bacteria 2|Bacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_449523_1 261292.Nit79A3_2781 2.63e-19 86.3 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2VHZZ@28216|Betaproteobacteria,3729W@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_449523_2 925775.XVE_3411 1.71e-23 100.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X31B@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_19781_1 929558.SMGD1_2432 1.36e-67 218.0 COG1565@1|root,COG1565@2|Bacteria,1QNDB@1224|Proteobacteria,42MQ8@68525|delta/epsilon subdivisions,2YNBU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_253646_1 999541.bgla_1g32730 1.91e-75 234.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHUJ@28216|Betaproteobacteria,1K1GV@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_253646_2 1279009.ADICEAN_03078 2.2e-185 532.0 COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,47P0R@768503|Cytophagia 976|Bacteroidetes S Peptidase family M49 - - - - - - - - - - - - Peptidase_M49 k59_646769_1 1121878.AUGL01000031_gene3505 8.43e-55 183.0 COG0131@1|root,COG0241@1|root,COG0131@2|Bacteria,COG0241@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Histidine biosynthesis bifunctional protein HisB hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iUMNK88_1353.UMNK88_2570 Hydrolase_like,IGPD,PNK3P k59_318012_1 1121405.dsmv_3712 1.83e-55 189.0 28I62@1|root,2Z896@2|Bacteria,1MWB8@1224|Proteobacteria,42P7E@68525|delta/epsilon subdivisions,2WKM1@28221|Deltaproteobacteria,2MIBX@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_940652_1 391625.PPSIR1_03943 9.3e-57 187.0 COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,42UJZ@68525|delta/epsilon subdivisions,2WQCC@28221|Deltaproteobacteria,2YV77@29|Myxococcales 28221|Deltaproteobacteria F adenosine deaminase add - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_254100_2 765912.Thimo_0237 1.84e-64 213.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales 135613|Chromatiales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_285256_1 641526.ADIWIN_0151 4.84e-09 53.9 2EFFE@1|root,33G5P@2|Bacteria,4NYX4@976|Bacteroidetes,1I6RS@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_777112_1 631362.Thi970DRAFT_02291 1.63e-162 480.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales 135613|Chromatiales M HAD-superfamily hydrolase, subfamily IIB - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_549429_1 1121949.AQXT01000002_gene2614 6.83e-30 123.0 COG2271@1|root,COG2271@2|Bacteria 2|Bacteria G transmembrane transporter activity - - - - - - - - - - - - MFS_1 k59_353494_1 265072.Mfla_2509 1.04e-96 312.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,2KKBF@206350|Nitrosomonadales 206350|Nitrosomonadales E Vitamin B12 dependent methionine synthase activation - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_711948_1 244581.IM40_01945 3.42e-12 71.6 COG2982@1|root,COG2982@2|Bacteria,1MUNH@1224|Proteobacteria,2TT0W@28211|Alphaproteobacteria,47FAC@766|Rickettsiales 766|Rickettsiales M AsmA family asmA - - ko:K07289 - - - - ko00000 - - - AsmA,AsmA_2 k59_20352_1 1178825.ALIH01000014_gene1957 7.18e-06 54.7 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1HXUN@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_907744_1 1168034.FH5T_15450 1.93e-46 156.0 COG0330@1|root,COG0330@2|Bacteria,4NEBV@976|Bacteroidetes,2FPV3@200643|Bacteroidia 976|Bacteroidetes O SPFH Band 7 PHB domain protein - - - - - - - - - - - - Band_7 k59_907744_2 688270.Celal_2716 4.52e-08 56.6 2E30A@1|root,32Y0V@2|Bacteria,4NPVG@976|Bacteroidetes,1I2I5@117743|Flavobacteriia,1FA9G@104264|Cellulophaga 976|Bacteroidetes - - - - - - - - - - - - - - DUF1705 k59_157874_1 981336.F944_00248 4.34e-42 139.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,1S6KR@1236|Gammaproteobacteria,3NP7G@468|Moraxellaceae 1236|Gammaproteobacteria L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_157874_2 1485545.JQLW01000013_gene1787 5.38e-134 385.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_743141_1 323261.Noc_1667 2.11e-119 349.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1WWWT@135613|Chromatiales 135613|Chromatiales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_647280_1 1121405.dsmv_1511 2.98e-57 191.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJUN@28221|Deltaproteobacteria,2MIK6@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_285277_1 572544.Ilyop_0463 9.28e-43 142.0 COG1607@1|root,COG1607@2|Bacteria 2|Bacteria I acyl-coa hydrolase yciA - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT k59_517772_1 511062.GU3_10400 2.42e-54 192.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1Y3TA@135624|Aeromonadales 135624|Aeromonadales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_417010_1 314278.NB231_12496 2.05e-55 194.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_806422_1 439235.Dalk_1637 1.14e-22 101.0 COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,42UM2@68525|delta/epsilon subdivisions,2WR61@28221|Deltaproteobacteria 28221|Deltaproteobacteria GM PFAM NAD dependent epimerase dehydratase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_711960_1 1209072.ALBT01000058_gene932 2.83e-06 57.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_318414_1 697282.Mettu_2589 6.89e-12 65.5 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1XE36@135618|Methylococcales 135618|Methylococcales O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_318414_2 1238182.C882_3120 2.55e-46 156.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2U78A@28211|Alphaproteobacteria,2JS4Y@204441|Rhodospirillales 204441|Rhodospirillales S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_614537_1 699246.HMPREF0868_1540 8.16e-23 94.4 COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,268U8@186813|unclassified Clostridiales 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_614537_2 267747.PPA1862 7.2e-38 135.0 COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4DN59@85009|Propionibacteriales 201174|Actinobacteria J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_743151_1 269797.Mbar_A1248 2.92e-62 194.0 COG1943@1|root,arCOG02759@2157|Archaea,2XWPT@28890|Euryarchaeota 28890|Euryarchaeota L COG1943 Transposase and inactivated derivatives - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_1006396_1 857087.Metme_0310 3.96e-46 162.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1XEDR@135618|Methylococcales 135618|Methylococcales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1006396_2 765912.Thimo_1430 1.97e-05 46.6 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXK2@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_743152_1 1232683.ADIMK_0084 4.71e-138 410.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,464A6@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_123961_1 749222.Nitsa_1712 1.53e-55 182.0 COG1216@1|root,COG1216@2|Bacteria,1N78N@1224|Proteobacteria 1224|Proteobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - - k59_941235_1 1122604.JONR01000004_gene853 6.07e-35 137.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales 135614|Xanthomonadales S cAMP biosynthetic process - - - - - - - - - - - - - k59_647296_1 1249480.B649_03885 5.79e-143 413.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2YMBD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_20396_1 1121405.dsmv_3476 1.07e-108 337.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MJ6A@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_2300 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_973195_1 632518.Calow_0655 5.86e-204 591.0 COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,42EYD@68295|Thermoanaerobacterales 186801|Clostridia J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_123964_1 713586.KB900536_gene2702 5.21e-32 128.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1WWF7@135613|Chromatiales 135613|Chromatiales H TonB-dependent Receptor Plug - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_874832_2 469618.FVAG_01777 5.68e-57 189.0 COG4866@1|root,COG4866@2|Bacteria,378DP@32066|Fusobacteria 32066|Fusobacteria S Uncharacterised conserved protein (DUF2156) - - - ko:K01163 - - - - ko00000 - - - DUF2156 k59_318433_1 1049564.TevJSym_an00630 5.17e-129 375.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1J4WN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_941247_1 469618.FVAG_02835 2.28e-86 264.0 COG1052@1|root,COG1052@2|Bacteria,379ME@32066|Fusobacteria 32066|Fusobacteria C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family ldhA - 1.1.1.28 ko:K03778 ko00620,ko01120,map00620,map01120 - R00704 RC00044 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_482084_1 1168034.FH5T_00885 8.03e-78 246.0 COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes,2FWNU@200643|Bacteroidia 976|Bacteroidetes S Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_222361_1 998674.ATTE01000001_gene2518 8.79e-100 301.0 COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,461R6@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF - 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_254157_1 1168034.FH5T_11165 1.68e-118 350.0 COG1109@1|root,COG1109@2|Bacteria,4NG3H@976|Bacteroidetes,2FM6E@200643|Bacteroidia 976|Bacteroidetes G Phosphoglucosamine mutase glmM - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_973202_1 1095769.CAHF01000001_gene3553 2.39e-91 275.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VHFS@28216|Betaproteobacteria,4737I@75682|Oxalobacteraceae 28216|Betaproteobacteria ET Bacterial periplasmic substrate-binding proteins gltI - - ko:K10001 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - SBP_bac_3 k59_549478_1 765910.MARPU_00770 1e-64 213.0 COG2334@1|root,COG2334@2|Bacteria,1Q18Y@1224|Proteobacteria,1RR8Y@1236|Gammaproteobacteria,1WWTK@135613|Chromatiales 135613|Chromatiales S Phosphotransferase - - - - - - - - - - - - APH k59_806446_2 335543.Sfum_0246 6.55e-112 336.0 COG2006@1|root,COG2221@1|root,COG2006@2|Bacteria,COG2221@2|Bacteria,1RABP@1224|Proteobacteria,42QQA@68525|delta/epsilon subdivisions,2WMRX@28221|Deltaproteobacteria,2MQEY@213462|Syntrophobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362,Fer4 k59_190017_1 367737.Abu_2326 2.24e-16 81.3 COG0642@1|root,COG0642@2|Bacteria,1N5IQ@1224|Proteobacteria,42N7Z@68525|delta/epsilon subdivisions,2YN64@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_353540_1 710696.Intca_2682 1.12e-62 212.0 COG4653@1|root,COG4653@2|Bacteria,2I9AZ@201174|Actinobacteria 201174|Actinobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_1006423_1 1232437.KL662050_gene5389 4.81e-16 73.9 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MI9D@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 k59_392101_1 349520.PPE_03011 4.44e-42 161.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_359099_1 382464.ABSI01000012_gene2198 1.01e-61 216.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C k59_456978_1 1168034.FH5T_21005 2.67e-104 303.0 COG0716@1|root,COG0716@2|Bacteria,4NTUA@976|Bacteroidetes,2FTX7@200643|Bacteroidia 976|Bacteroidetes C Flavodoxin - - - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 k59_456978_2 1168034.FH5T_21000 4.69e-28 110.0 COG0436@1|root,COG0436@2|Bacteria,4NHP7@976|Bacteroidetes,2FN3D@200643|Bacteroidia 976|Bacteroidetes E Aminotransferase, class I alaC - - - - - - - - - - - Aminotran_1_2 k59_359101_1 95619.PM1_0225640 0.000199 45.4 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_359101_2 583355.Caka_2268 6.71e-07 50.4 COG0848@1|root,COG0848@2|Bacteria,46VV0@74201|Verrucomicrobia 74201|Verrucomicrobia U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1044203_1 86416.Clopa_2016 5.04e-22 95.5 COG1740@1|root,COG1740@2|Bacteria,1TZZD@1239|Firmicutes,2489B@186801|Clostridia,36EWC@31979|Clostridiaceae 186801|Clostridia C Hydrogenase (NiFe) small subunit HydA hupS - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_129733_1 1410612.JNKO01000017_gene2974 7.77e-66 224.0 COG1882@1|root,COG1882@2|Bacteria,1W6Y3@1239|Firmicutes,25MGH@186801|Clostridia,2PTJ3@265975|Oribacterium 186801|Clostridia C Pyruvate formate lyase-like - - - - - - - - - - - - Gly_radical,PFL-like k59_291014_1 1336233.JAEH01000002_gene1372 3.59e-39 155.0 COG1922@1|root,COG2148@1|root,COG1922@2|Bacteria,COG2148@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,2QAQA@267890|Shewanellaceae 1236|Gammaproteobacteria M TIGRFAM glycosyl transferase, WecB TagA CpsF family gumM - 2.4.1.187 ko:K05946,ko:K13660 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Bac_transf,Glyco_tran_WecB k59_392115_1 926569.ANT_14120 2.11e-30 121.0 COG2271@1|root,COG2271@2|Bacteria 2|Bacteria G transmembrane transporter activity - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - Acatn,MFS_1 k59_196136_1 1168034.FH5T_04745 2.31e-135 394.0 COG1160@1|root,COG1160@2|Bacteria,4NE2J@976|Bacteroidetes,2FN63@200643|Bacteroidia 976|Bacteroidetes S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1044208_1 1202962.KB907151_gene927 4.14e-30 123.0 COG1574@1|root,COG3126@1|root,COG1574@2|Bacteria,COG3126@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3,YscW k59_717662_1 247156.NFA_28090 1.42e-31 126.0 2EWTS@1|root,33Q5B@2|Bacteria,2HZQX@201174|Actinobacteria,4FXWW@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_456988_1 768706.Desor_2590 4.31e-44 153.0 COG4925@1|root,COG4925@2|Bacteria,1VA4J@1239|Firmicutes,24MKE@186801|Clostridia 186801|Clostridia C FMN binding - - - - - - - - - - - - Flavodoxin_4 k59_26196_1 1318628.MARLIPOL_05365 1.57e-47 161.0 2DK8S@1|root,308W6@2|Bacteria,1NEC2@1224|Proteobacteria 1224|Proteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_26196_3 1123487.KB892838_gene3806 5.32e-26 107.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VMKP@28216|Betaproteobacteria,2KV5U@206389|Rhodocyclales 206389|Rhodocyclales H Acetolactate synthase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_947140_1 751944.HALDL1_01915 4.93e-47 162.0 COG0702@1|root,arCOG03015@2157|Archaea,2XT7V@28890|Euryarchaeota,23T9H@183963|Halobacteria 183963|Halobacteria M Nucleoside-diphosphate-sugar epimerases - - - - - - - - - - - - NAD_binding_10 k59_62190_1 1049564.TevJSym_ab01840 2.43e-55 177.0 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1J6Y3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG2927 DNA polymerase III, chi subunit holC GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_847798_1 1165841.SULAR_03782 2.09e-117 363.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2YMSQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II k59_422633_2 765913.ThidrDRAFT_1869 2.46e-27 105.0 2A08H@1|root,30NBS@2|Bacteria,1RDGP@1224|Proteobacteria,1S4RA@1236|Gammaproteobacteria,1WYDC@135613|Chromatiales 135613|Chromatiales S [NiFe]-hydrogenase assembly, chaperone, HybE - - - - - - - - - - - - NiFe-hyd_HybE k59_487579_1 1249627.D779_2379 5e-54 180.0 COG1275@1|root,COG1275@2|Bacteria,1MVPG@1224|Proteobacteria,1RPVM@1236|Gammaproteobacteria,1WWJ7@135613|Chromatiales 135613|Chromatiales P PFAM C4-dicarboxylate transporter malic acid transport protein - - - ko:K03304 - - - - ko00000,ko02000 2.A.16.1 - - SLAC1 k59_129746_1 1430440.MGMSRv2_2000 1.29e-76 235.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2TURW@28211|Alphaproteobacteria,2JPFC@204441|Rhodospirillales 204441|Rhodospirillales C Cytochrome c-type protein - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT k59_62191_1 585531.HMPREF0063_11133 2.4e-09 63.2 COG1028@1|root,COG1028@2|Bacteria,2HESV@201174|Actinobacteria,4DV1B@85009|Propionibacteriales 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_291027_1 1150621.SMUL_1547 3.05e-47 161.0 COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions 1224|Proteobacteria F Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_2242,iSF_1195.SF2059,iSFxv_1172.SFxv_2293,iS_1188.S2169 DBI_PRT k59_291027_2 596323.HMPREF0554_0339 6.48e-31 115.0 COG0406@1|root,COG0406@2|Bacteria,37939@32066|Fusobacteria 32066|Fusobacteria G Psort location Cytoplasmic, score 8.96 - - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_1044216_2 693979.Bache_1018 6.49e-45 145.0 2C8VT@1|root,32RN1@2|Bacteria,4NS78@976|Bacteroidetes,2FTSK@200643|Bacteroidia,4ARQ3@815|Bacteroidaceae 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF2795 k59_1044216_3 1168034.FH5T_19680 1.14e-26 100.0 COG3370@1|root,COG3370@2|Bacteria,4NRQG@976|Bacteroidetes,2FTBG@200643|Bacteroidia 976|Bacteroidetes O Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - DrsE k59_228333_1 985255.APHJ01000031_gene2794 2.12e-30 120.0 COG1418@1|root,COG1418@2|Bacteria,4NE3V@976|Bacteroidetes,1HYHI@117743|Flavobacteriia,2P5E4@244698|Gillisia 976|Bacteroidetes S Domain of unknown function (DUF3552) rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_587542_1 1123326.JFBL01000001_gene1280 3.71e-194 555.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_62197_1 1537917.JU82_07415 2.4e-99 297.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,42MC1@68525|delta/epsilon subdivisions,2YMD0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M ADP-L-glycero-D-manno-heptose-6-epimerase waaD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_587550_2 498211.CJA_0343 1.72e-06 52.8 COG1520@1|root,COG3209@1|root,COG1520@2|Bacteria,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - Calx-beta,DUF1566,DUF4114,DUF4347,FG-GAP,HemolysinCabind,PQQ_3,RHS,RHS_repeat,SLH k59_947156_1 1122599.AUGR01000001_gene375 2.18e-05 52.4 2DSV1@1|root,33HI7@2|Bacteria,1P87Q@1224|Proteobacteria 1224|Proteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_652536_1 1123023.JIAI01000002_gene4825 2.66e-08 58.2 COG0115@1|root,COG0115@2|Bacteria,2HFYZ@201174|Actinobacteria,4EB5G@85010|Pseudonocardiales 201174|Actinobacteria EH Amino-transferase class IV - - - - - - - - - - - - Aminotran_4 k59_652536_2 265072.Mfla_2499 7.3e-24 93.6 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,2KN2V@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein of unknown function (DUF493) - - - ko:K09158 - - - - ko00000 - - - DUF493 k59_652536_3 1042209.HK44_017795 7.34e-66 207.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1YNXZ@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718 BPL_LplA_LipB k59_26220_1 76114.ebA3810 1.13e-23 94.7 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,2VUEX@28216|Betaproteobacteria,2KWR4@206389|Rhodocyclales 206389|Rhodocyclales U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_587562_1 399739.Pmen_3562 9.17e-86 273.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RNBK@1236|Gammaproteobacteria,1YDAK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_422657_1 1537917.JU82_04820 7.31e-109 323.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,42N1M@68525|delta/epsilon subdivisions,2YN3T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_587567_1 1168034.FH5T_03110 3.4e-51 164.0 COG4109@1|root,COG4109@2|Bacteria,4NTDQ@976|Bacteroidetes,2FTXG@200643|Bacteroidia 976|Bacteroidetes K DRTGG domain - - - - - - - - - - - - DRTGG k59_587567_2 1168034.FH5T_03105 1.67e-67 207.0 COG2172@1|root,COG2172@2|Bacteria,4NRAS@976|Bacteroidetes,2FT57@200643|Bacteroidia 976|Bacteroidetes T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c,HATPase_c_2 k59_587567_3 1168034.FH5T_03100 1.52e-105 318.0 COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,4NJAS@976|Bacteroidetes,2FMHZ@200643|Bacteroidia 976|Bacteroidetes C Iron only hydrogenase large subunit, C-terminal domain - - - - - - - - - - - - FeS,Fe_hyd_lg_C,Fer4,Fer4_6 k59_457027_1 1313421.JHBV01000014_gene3891 0.000115 50.4 COG1629@1|root,COG1629@2|Bacteria 2|Bacteria P transport - - - - - - - - - - - - CarbopepD_reg_2,OMP_b-brl_3,Plug k59_291053_1 377629.TERTU_4697 2.87e-82 259.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria,2PQ4J@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Arsenical pump membrane protein - - - - - - - - - - - - CitMHS k59_979076_1 96561.Dole_2039 3.64e-106 314.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MIRN@213118|Desulfobacterales 28221|Deltaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_96534_1 644282.Deba_1636 2.9e-32 124.0 COG2875@1|root,COG2875@2|Bacteria,1RACR@1224|Proteobacteria,42R8K@68525|delta/epsilon subdivisions,2WN37@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase - - - - - - - - - - - - TP_methylase k59_913453_1 749222.Nitsa_1910 1.72e-52 179.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ5@1224|Proteobacteria,42NJC@68525|delta/epsilon subdivisions,2YMGQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase cosS - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_587575_1 1408444.JHYC01000030_gene1292 3.47e-44 159.0 COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1JDR9@118969|Legionellales 118969|Legionellales P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_487614_1 1123368.AUIS01000013_gene875 1.39e-33 119.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,2NCUZ@225057|Acidithiobacillales 225057|Acidithiobacillales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_487614_2 519989.ECTPHS_13088 9.26e-105 308.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1WVYC@135613|Chromatiales 135613|Chromatiales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_392169_1 572544.Ilyop_0931 3.4e-40 141.0 COG0582@1|root,COG0582@2|Bacteria,379QR@32066|Fusobacteria 32066|Fusobacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_359163_1 1122951.ATUE01000007_gene595 1.05e-100 296.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,1RQNI@1236|Gammaproteobacteria,3NKTR@468|Moraxellaceae 1236|Gammaproteobacteria G Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II k59_422679_1 1260251.SPISAL_01180 1.62e-133 408.0 COG0475@1|root,COG1226@1|root,COG3273@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,COG3273@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales 135613|Chromatiales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_129753_1 469616.FMAG_01330 5.49e-119 352.0 COG0412@1|root,COG0412@2|Bacteria 2|Bacteria Q carboxymethylenebutenolidase activity - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - Abhydrolase_7,DLH,Peptidase_S9 k59_129753_2 1408422.JHYF01000011_gene3473 0.0 1222.0 COG0683@1|root,COG1361@1|root,COG2755@1|root,COG5263@1|root,COG0683@2|Bacteria,COG1361@2|Bacteria,COG2755@2|Bacteria,COG5263@2|Bacteria,1TS5Q@1239|Firmicutes,24AGK@186801|Clostridia,36V4D@31979|Clostridiaceae 186801|Clostridia M Parallel beta-helix repeats - - - - - - - - - - - - Beta_helix,Big_3,CW_binding_1,Pectinesterase,SLH,fn3 k59_129753_3 1134474.O59_002385 1.75e-105 333.0 COG2755@1|root,COG2755@2|Bacteria,1QV8G@1224|Proteobacteria,1T29W@1236|Gammaproteobacteria,1FFRP@10|Cellvibrio 1236|Gammaproteobacteria E GDSL-like Lipase/Acylhydrolase family paeY - - - - - - - - - - - Lipase_GDSL_2 k59_129753_7 46256.BBIK01000004_gene736 3.38e-32 129.0 COG0679@1|root,COG0679@2|Bacteria,1UFHP@1239|Firmicutes,4IES7@91061|Bacilli,4AYCY@81850|Leuconostocaceae 91061|Bacilli S Membrane transport protein - - - - - - - - - - - - Mem_trans k59_129753_8 1347369.CCAD010000019_gene1369 3.12e-37 140.0 COG2755@1|root,COG4677@1|root,COG2755@2|Bacteria,COG4677@2|Bacteria,1UYI6@1239|Firmicutes,4HHAB@91061|Bacilli,1ZSFX@1386|Bacillus 91061|Bacilli G Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pectinesterase k59_587610_1 572544.Ilyop_0940 9.65e-107 315.0 COG0648@1|root,COG0648@2|Bacteria,378DZ@32066|Fusobacteria 32066|Fusobacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_913467_1 1168034.FH5T_10280 2.45e-79 244.0 COG0095@1|root,COG0095@2|Bacteria,4NE5F@976|Bacteroidetes,2FMDJ@200643|Bacteroidia 976|Bacteroidetes H Lipoate-protein ligase lplA - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB,Lip_prot_lig_C k59_812477_1 318167.Sfri_2285 1.17e-45 151.0 COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,1S6BB@1236|Gammaproteobacteria,2QC1C@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM NADH-ubiquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_812477_2 351016.RAZWK3B_13834 1.13e-07 55.8 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,2P22Y@2433|Roseobacter 28211|Alphaproteobacteria CP COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit phaD - - ko:K05561 - - - - ko00000,ko02000 2.A.63.1 - - Proton_antipo_M k59_228370_1 391619.PGA1_c34080 2.45e-21 95.5 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2TSZM@28211|Alphaproteobacteria,34DXI@302485|Phaeobacter 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_359173_1 1049564.TevJSym_aa00370 1.91e-199 576.0 COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1J5G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon2 - 3.4.21.53 ko:K01338,ko:K08675 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002,ko03029 - - - AAA,LON_substr_bdg,Lon_C k59_291096_1 1537915.JU57_01955 9.41e-40 142.0 COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,42UNC@68525|delta/epsilon subdivisions,2YQNU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_96576_1 443143.GM18_0882 1.86e-37 141.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_260748_3 1537917.JU82_02715 1.45e-65 202.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,42S1N@68525|delta/epsilon subdivisions,2YPJI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin k59_260748_4 1537917.JU82_02710 2.76e-45 150.0 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,42ST2@68525|delta/epsilon subdivisions,2YPG7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_260760_1 215803.DB30_2967 1.06e-165 474.0 2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,42Y78@68525|delta/epsilon subdivisions,2X3CW@28221|Deltaproteobacteria,2YUS0@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF2891) - - - - - - - - - - - - DUF2891 k59_362383_2 1238450.VIBNISOn1_470002 1.23e-137 399.0 2EADA@1|root,334H4@2|Bacteria,1N9H0@1224|Proteobacteria,1SM46@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_362383_3 296591.Bpro_1557 7.06e-202 570.0 COG1106@1|root,COG1106@2|Bacteria,1MVU0@1224|Proteobacteria,2VMJQ@28216|Betaproteobacteria,4ACCE@80864|Comamonadaceae 28216|Betaproteobacteria S AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K06926 - - - - ko00000 - - - AAA_21 k59_362383_4 296591.Bpro_1558 4.81e-92 276.0 2DNYB@1|root,32ZS8@2|Bacteria,1RF1E@1224|Proteobacteria,2VRNZ@28216|Betaproteobacteria,4AE6U@80864|Comamonadaceae 28216|Betaproteobacteria S RloB-like protein - - - - - - - - - - - - RloB k59_362383_6 1049564.TevJSym_ag00400 4.48e-185 521.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1J4GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0421 Glycos_trans_3N,Glycos_transf_3 k59_362383_7 519989.ECTPHS_03769 5.87e-109 317.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1WVVN@135613|Chromatiales 135613|Chromatiales EH TIGRFAM glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_362383_8 765911.Thivi_3479 3.13e-285 788.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales 135613|Chromatiales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_362383_9 722419.PH505_cw00130 3.7e-72 234.0 COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria,1T2BY@1236|Gammaproteobacteria,2Q0SS@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG1226 Kef-type K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_362383_10 545276.KB898735_gene1302 1.93e-130 374.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1WX9I@135613|Chromatiales 135613|Chromatiales G Belongs to the ribulose-phosphate 3-epimerase family - - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_362383_11 413404.Rmag_0376 7.64e-29 118.0 COG1073@1|root,COG1073@2|Bacteria,1N1WH@1224|Proteobacteria,1S9JK@1236|Gammaproteobacteria,1JBBD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3530) - - - - - - - - - - - - DUF3530 k59_362383_12 631362.Thi970DRAFT_02209 5.64e-127 370.0 COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,1RRC5@1236|Gammaproteobacteria,1WXE3@135613|Chromatiales 135613|Chromatiales G PFAM Fructosamine - - - - - - - - - - - - Fructosamin_kin k59_362383_13 2340.JV46_06250 2.11e-101 298.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1J60R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG1403 Restriction endonuclease - - - - - - - - - - - - HNH_5 k59_362383_15 765912.Thimo_2397 2.62e-278 791.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales 135613|Chromatiales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_362383_16 749222.Nitsa_1488 5.69e-53 178.0 COG3850@1|root,COG3850@2|Bacteria,1NUYP@1224|Proteobacteria,42YP4@68525|delta/epsilon subdivisions,2YRKD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Type IV pili methyl-accepting chemotaxis transducer N-term - - - - - - - - - - - - PilJ k59_362383_17 1049564.TevJSym_ak00590 0.0 962.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1J5IS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_362383_18 1049564.TevJSym_ak00580 4.35e-39 140.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1J6IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG3087 Cell division protein ftsN - - ko:K03591 - - - - ko00000,ko03036 - - - SPOR k59_362383_21 7668.SPU_003703-tr 7.75e-19 92.4 KOG1565@1|root,KOG1565@2759|Eukaryota,38CRR@33154|Opisthokonta,3B9IY@33208|Metazoa,3CT1E@33213|Bilateria 33208|Metazoa O Belongs to the peptidase M10A family Mmp1 GO:0001838,GO:0002009,GO:0002164,GO:0002165,GO:0002168,GO:0003007,GO:0003143,GO:0003144,GO:0005575,GO:0005623,GO:0006950,GO:0007155,GO:0007275,GO:0007399,GO:0007413,GO:0007417,GO:0007419,GO:0007424,GO:0007444,GO:0007503,GO:0007505,GO:0007507,GO:0007552,GO:0007560,GO:0007561,GO:0007591,GO:0008037,GO:0008038,GO:0008150,GO:0009611,GO:0009653,GO:0009790,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009987,GO:0016043,GO:0016331,GO:0022008,GO:0022411,GO:0022610,GO:0030030,GO:0030154,GO:0030182,GO:0030198,GO:0030425,GO:0031099,GO:0031175,GO:0032501,GO:0032502,GO:0034330,GO:0034769,GO:0035001,GO:0035050,GO:0035148,GO:0035150,GO:0035151,GO:0035152,GO:0035159,GO:0035239,GO:0035295,GO:0036477,GO:0040007,GO:0042060,GO:0042246,GO:0042303,GO:0042995,GO:0043005,GO:0043062,GO:0044463,GO:0044464,GO:0045216,GO:0048468,GO:0048513,GO:0048562,GO:0048563,GO:0048568,GO:0048569,GO:0048589,GO:0048598,GO:0048646,GO:0048666,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048856,GO:0048869,GO:0050896,GO:0060429,GO:0060541,GO:0060560,GO:0060562,GO:0060612,GO:0061448,GO:0061564,GO:0065007,GO:0065008,GO:0071711,GO:0071840,GO:0072175,GO:0072359,GO:0090066,GO:0097156,GO:0097447,GO:0097458,GO:0106030,GO:0120025,GO:0120036,GO:0120038 3.4.24.80 ko:K07763 ko04668,ko04912,map04668,map04912 - - - ko00000,ko00001,ko01000,ko01002 - - - Hemopexin,PG_binding_1,Peptidase_M10 k59_362383_23 1049564.TevJSym_ak00570 6.39e-25 96.3 2EGR8@1|root,33AHD@2|Bacteria,1N6Z8@1224|Proteobacteria,1SDY4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S FeoC like transcriptional regulator - - - - - - - - - - - - FeoC k59_362383_24 1049564.TevJSym_ak00560 0.0 1035.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1J5MJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_362383_25 743299.Acife_2444 8.25e-07 50.1 COG1918@1|root,COG1918@2|Bacteria,1NH7U@1224|Proteobacteria,1T8TX@1236|Gammaproteobacteria,2NDET@225057|Acidithiobacillales 225057|Acidithiobacillales P FeoA domain - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_362383_26 1121035.AUCH01000006_gene673 3.07e-82 252.0 COG0500@1|root,COG2226@2|Bacteria,1RKQD@1224|Proteobacteria,2VQJ7@28216|Betaproteobacteria,2KUBG@206389|Rhodocyclales 206389|Rhodocyclales Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_362383_27 1049564.TevJSym_ak00520 1.5e-158 452.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1J69M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_362383_28 1049564.TevJSym_ak00510 7.32e-65 206.0 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU,PEMT k59_362383_29 396588.Tgr7_1284 1.65e-08 55.1 2A7N8@1|root,30WK9@2|Bacteria,1QSI4@1224|Proteobacteria,1SX3K@1236|Gammaproteobacteria,1X1QK@135613|Chromatiales 135613|Chromatiales S PFAM Type IV pilus assembly PilZ - - - - - - - - - - - - PilZ k59_362383_30 765913.ThidrDRAFT_3979 1.25e-139 404.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales 135613|Chromatiales CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_362383_31 572477.Alvin_1073 0.0 1811.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_362383_33 1499967.BAYZ01000033_gene1095 1.99e-23 105.0 COG3829@1|root,COG3829@2|Bacteria 2|Bacteria T transcription factor binding - - - ko:K02584,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022,ko03000 - - - GAF,GAF_2,HTH_8,PocR,Sigma54_activat,Yop-YscD_cpl k59_362383_34 243233.MCA0466 1.51e-139 431.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1XDJ9@135618|Methylococcales 135618|Methylococcales E Domain of unknown function (DUF3488) - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_362383_35 765910.MARPU_00635 3.89e-71 230.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1WWD0@135613|Chromatiales 135613|Chromatiales S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_362383_36 631362.Thi970DRAFT_03646 6.8e-140 404.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1WXIF@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_362383_37 765912.Thimo_0136 1.13e-50 171.0 292F7@1|root,2ZPZF@2|Bacteria,1RGFI@1224|Proteobacteria,1S48P@1236|Gammaproteobacteria,1WY8A@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_362383_38 1469245.JFBG01000030_gene1547 1.09e-112 340.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1WXT8@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0118 - - - - - - - - - - - - AI-2E_transport k59_362383_40 1049564.TevJSym_at00120 1.58e-200 565.0 COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,1RPND@1236|Gammaproteobacteria,1J945@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S TraB family traB - - - - - - - - - - - TraB k59_362383_41 392500.Swoo_0681 2.59e-42 146.0 2DZH7@1|root,32VAP@2|Bacteria,1N6FC@1224|Proteobacteria,1SABS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - TerB k59_362383_42 713586.KB900536_gene35 2.62e-64 230.0 COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T domain protein - - - - - - - - - - - - CBS,GAF_2,HD,HD_5,PAS_4,PAS_9 k59_362383_43 323850.Shew_0884 7.07e-68 216.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,2Q9UJ@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM Nucleotidyl transferase - GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.99 ko:K00966,ko:K00992 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_362383_44 323261.Noc_2286 6.83e-169 491.0 COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1WWXK@135613|Chromatiales 135613|Chromatiales S glutamate--cysteine ligase - - - - - - - - - - - - GCS2 k59_362383_45 572477.Alvin_2542 6.36e-146 422.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria,1WWYR@135613|Chromatiales 135613|Chromatiales S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_362383_46 1255043.TVNIR_0483 1.33e-51 164.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1WYJ2@135613|Chromatiales 135613|Chromatiales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_362383_47 1049564.TevJSym_bj00170 8.89e-314 864.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1J4FJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009986,GO:0009987,GO:0016465,GO:0018995,GO:0022610,GO:0030430,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0050789,GO:0051082,GO:0051704,GO:0061077,GO:0065007,GO:0101031,GO:1990220,GO:2000535 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_362383_48 765913.ThidrDRAFT_0075 0.0 1071.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_362383_49 765913.ThidrDRAFT_0074 2.27e-196 547.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales 135613|Chromatiales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_362383_50 686340.Metal_3841 2.03e-130 382.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1XEXK@135618|Methylococcales 135618|Methylococcales M TIGRFAM Lipopolysaccharide heptosyltransferase II - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_624566_1 1168034.FH5T_13525 1.64e-96 309.0 COG0553@1|root,COG0553@2|Bacteria,4NG6P@976|Bacteroidetes,2FPNU@200643|Bacteroidia 976|Bacteroidetes L SNF2 family N-terminal domain - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Helicase_C,SNF2_N k59_690020_1 1165841.SULAR_04517 6e-18 80.9 COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions 1224|Proteobacteria S (twin-arginine translocation) pathway signal - - - - - - - - - - - - Ysc84 k59_690020_2 1408442.JADE01000007_gene921 1.17e-79 242.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2YNXC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iIT341.HP0618 ADK k59_690020_3 598659.NAMH_1045 1.93e-23 99.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2YMJV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_690024_1 765912.Thimo_3399 6.18e-52 171.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria,1WYE4@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_690024_2 321846.PS417_05150 3.17e-32 125.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_919203_1 909943.HIMB100_00015760 5.68e-23 103.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,4BSMX@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_787925_2 1165841.SULAR_08010 1.16e-59 184.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,42THY@68525|delta/epsilon subdivisions,2YPFU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_787925_3 387093.SUN_2326 7.22e-19 79.3 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2YPJZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_134519_1 1168034.FH5T_10400 2.89e-25 103.0 COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes,2FM1V@200643|Bacteroidia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_134519_2 1168034.FH5T_10395 5.72e-81 249.0 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,2FQSG@200643|Bacteroidia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23,OEP k59_232365_1 709032.Sulku_1918 8.92e-23 97.4 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,42N04@68525|delta/epsilon subdivisions,2YMF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_232365_2 929558.SMGD1_0747 3.17e-190 536.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2YMW7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_232365_3 709032.Sulku_1920 9.58e-100 298.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2YNAN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Chorismate mutase prephenate dehydratase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_591410_1 1049564.TevJSym_af00580 6.64e-15 74.7 2A494@1|root,30SUJ@2|Bacteria,1NCCT@1224|Proteobacteria,1SX6S@1236|Gammaproteobacteria,1J77W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_591410_2 240016.ABIZ01000001_gene5889 7.7e-07 61.6 COG0457@1|root,COG0457@2|Bacteria,46V4J@74201|Verrucomicrobia 74201|Verrucomicrobia S Tetratricopeptide repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_8 k59_591410_3 1485544.JQKP01000005_gene418 3.59e-216 602.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2VIBX@28216|Betaproteobacteria,44VAE@713636|Nitrosomonadales 28216|Betaproteobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_591410_4 314292.VAS14_05903 2.36e-166 472.0 COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,1RMPQ@1236|Gammaproteobacteria,1XUPH@135623|Vibrionales 135623|Vibrionales GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_591410_6 443143.GM18_1587 6.6e-104 309.0 COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,42TWK@68525|delta/epsilon subdivisions,2WIJC@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM glycosyl transferase WecB TagA CpsF - - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB k59_591410_8 231434.JQJH01000034_gene1242 9.98e-103 314.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2U963@28211|Alphaproteobacteria,3NCFD@45404|Beijerinckiaceae 28211|Alphaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_591410_9 326426.Bbr_0451 2.63e-11 72.4 COG3594@1|root,COG3594@2|Bacteria,2GPJB@201174|Actinobacteria,4D1BX@85004|Bifidobacteriales 201174|Actinobacteria G Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_591410_12 443143.GM18_1619 1.25e-48 176.0 COG0438@1|root,COG0438@2|Bacteria,1RGJZ@1224|Proteobacteria 1224|Proteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1 k59_591410_14 762968.HMPREF9441_03534 2.74e-43 164.0 COG0438@1|root,COG0438@2|Bacteria,4NNU7@976|Bacteroidetes,2FU7N@200643|Bacteroidia 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_4_2,Glycos_transf_1 k59_591410_15 396595.TK90_1562 1.4e-70 222.0 COG0500@1|root,COG2226@2|Bacteria,1RG8C@1224|Proteobacteria,1SSHV@1236|Gammaproteobacteria,1X1GD@135613|Chromatiales 135613|Chromatiales H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_591410_16 1384057.CD33_09630 4.13e-13 74.7 COG1215@1|root,COG1215@2|Bacteria,1TRM2@1239|Firmicutes,4HFHG@91061|Bacilli 91061|Bacilli M COG0463, glycosyltransferases involved in cell wall biogenesis - - - ko:K19423 - - - - ko00000,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_591410_17 1292034.OR37_03058 1.82e-14 80.9 COG1216@1|root,COG1216@2|Bacteria,1RAIR@1224|Proteobacteria,2UDYT@28211|Alphaproteobacteria,2KIU0@204458|Caulobacterales 204458|Caulobacterales S Glycosyl transferase, family 2 - - - - - - - - - - - - - k59_591410_18 67315.JOBD01000012_gene355 2.56e-27 112.0 COG0726@1|root,COG0726@2|Bacteria,2H6C7@201174|Actinobacteria 201174|Actinobacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_591410_19 1300143.CCAV010000001_gene1421 7.89e-13 67.8 COG1045@1|root,COG1045@2|Bacteria 2|Bacteria E serine acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_591410_21 765913.ThidrDRAFT_2895 1.85e-99 318.0 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria,1WYEE@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 4 wecA - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_591410_22 1163617.SCD_n01348 7.39e-212 604.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VHWW@28216|Betaproteobacteria 28216|Betaproteobacteria C eight transmembrane protein EpsH - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_591410_23 999141.GME_02745 2.57e-153 444.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,1RPNC@1236|Gammaproteobacteria,1XH2E@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_591410_24 316067.Geob_3227 3.67e-176 504.0 COG0677@1|root,COG0677@2|Bacteria,1QV0P@1224|Proteobacteria,43BN8@68525|delta/epsilon subdivisions,2WTPE@28221|Deltaproteobacteria 28221|Deltaproteobacteria M UDP binding domain - - 1.1.1.336 ko:K02472 ko00520,ko05111,map00520,map05111 - R03317 RC00291 ko00000,ko00001,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_591410_25 572477.Alvin_0920 2.23e-229 646.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1WW64@135613|Chromatiales 135613|Chromatiales M Belongs to the mannose-6-phosphate isomerase type 2 family - - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_591410_26 329726.AM1_0803 4.8e-73 233.0 COG1091@1|root,COG1091@2|Bacteria,1G1CP@1117|Cyanobacteria 1117|Cyanobacteria M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - iJN678.rfbD RmlD_sub_bind k59_591410_27 1449050.JNLE01000003_gene2148 2.42e-144 418.0 COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,36DGP@31979|Clostridiaceae 186801|Clostridia M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_591410_28 1116472.MGMO_8c00410 3.21e-99 301.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1XERT@135618|Methylococcales 135618|Methylococcales U SMART ATPase, AAA type, core - - - - - - - - - - - - AAA_22 k59_591410_29 857087.Metme_2602 9.34e-63 205.0 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1XFZI@135618|Methylococcales 135618|Methylococcales D protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - - k59_591410_30 1163617.SCD_n01328 1.32e-139 424.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2VMDA@28216|Betaproteobacteria 28216|Betaproteobacteria M Polysaccharide chain length determinant protein - - - - - - - - - - - - Wzz k59_591410_32 1301098.PKB_1184 9.09e-12 70.5 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M polysaccharide export wza - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_591410_34 1286106.MPL1_01468 2.24e-133 400.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,46033@72273|Thiotrichales 72273|Thiotrichales M TIGRFAM type I secretion membrane fusion protein, HlyD family - - - ko:K12542 - M00330 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1 - - Biotin_lipoyl_2,HlyD_3,OEP k59_591410_35 1198232.CYCME_0399 7.26e-230 666.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,45ZQX@72273|Thiotrichales 72273|Thiotrichales V ABC transporter transmembrane region - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_591410_36 159087.Daro_1367 1.22e-09 66.6 COG1499@1|root,COG2771@1|root,COG1499@2|Bacteria,COG2771@2|Bacteria,1MWC0@1224|Proteobacteria,2VX3T@28216|Betaproteobacteria,2KZES@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - - k59_591410_37 360104.CCC13826_0888 7.82e-34 141.0 COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,42Q7M@68525|delta/epsilon subdivisions,2YNPH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU outer membrane protein, TolC family - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP k59_368136_1 1517681.HW45_03840 1.65e-38 145.0 COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,1SM5A@1236|Gammaproteobacteria,1XVNU@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214,DUF1254 k59_368136_2 1245471.PCA10_38050 7.53e-05 46.2 COG0671@1|root,COG0671@2|Bacteria,1R91F@1224|Proteobacteria,1S1DW@1236|Gammaproteobacteria,1YH3T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Acid phosphatase homologues - - 3.1.3.2 ko:K09474 ko00740,ko01100,ko02020,map00740,map01100,map02020 - R00548 RC00017 ko00000,ko00001,ko01000 - - - PAP2 k59_890238_1 749222.Nitsa_0456 1.56e-41 145.0 COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,42T0U@68525|delta/epsilon subdivisions,2YPN4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Uroporphyrinogen-III synthase hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_466242_1 395493.BegalDRAFT_2574 2.41e-54 192.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,46043@72273|Thiotrichales 1236|Gammaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_301691_1 1168034.FH5T_20715 2.86e-68 212.0 2AU2S@1|root,31JP5@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF1080 k59_301691_2 1313421.JHBV01000039_gene2649 4.45e-26 106.0 COG0513@1|root,COG0513@2|Bacteria,4NHCA@976|Bacteroidetes,1INR3@117747|Sphingobacteriia 976|Bacteroidetes L helicase superfamily c-terminal domain - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_400104_1 2340.JV46_22720 4.26e-152 434.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1J4YW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_400104_2 1218075.BAYA01000049_gene6762 1.74e-14 76.6 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,1KH4I@119060|Burkholderiaceae 28216|Betaproteobacteria Q PFAM toluene tolerance family protein ttg2D - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_400104_3 1177154.Y5S_03440 2.66e-06 47.4 COG2900@1|root,COG2900@2|Bacteria,1NGFM@1224|Proteobacteria,1SGAM@1236|Gammaproteobacteria,1XMNQ@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the SlyX family slyX - - ko:K03745 - - - - ko00000 - - - SlyX k59_400104_4 765913.ThidrDRAFT_0367 4.27e-61 195.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1WY2S@135613|Chromatiales 135613|Chromatiales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate tsaC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_400104_5 1278307.KB906992_gene3238 3.83e-76 231.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,2QI0Z@267894|Psychromonadaceae 1236|Gammaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_400104_6 1167006.UWK_00078 1.63e-179 511.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,42QX9@68525|delta/epsilon subdivisions,2WKS8@28221|Deltaproteobacteria,2MIGQ@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1 k59_400104_7 1049564.TevJSym_ag01090 0.0 1107.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1J526@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_400104_8 2340.JV46_25860 5.27e-55 177.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1J6PQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF494) smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_400104_9 1049564.TevJSym_ag01070 1.48e-134 397.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1J5T7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria LU Rossmann fold nucleotide-binding protein involved in DNA uptake smf - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_400104_10 105559.Nwat_3070 7.55e-106 321.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales 135613|Chromatiales S PFAM Peptidoglycan-binding lysin domain - - - - - - - - - - - - LysM k59_400104_11 1283300.ATXB01000001_gene1101 1.78e-71 220.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1XF14@135618|Methylococcales 135618|Methylococcales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_400104_12 399739.Pmen_0054 1.32e-121 358.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1YE83@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Formyl_trans_C,Formyl_trans_N k59_400104_13 1049564.TevJSym_ag01030 5.58e-160 465.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1J5DY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_400104_14 765911.Thivi_3195 7.54e-45 153.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_400104_15 1049564.TevJSym_ag01010 4.67e-253 725.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction Histidine kinase ntrY - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8 k59_400104_16 765911.Thivi_3193 3.56e-249 693.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_400104_17 1049564.TevJSym_ag00990 5.32e-245 682.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1J4GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0569 K transport systems, NAD-binding component trkA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655 - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iE2348C_1286.E2348C_3552 TrkA_C,TrkA_N k59_400104_18 765913.ThidrDRAFT_0382 4.34e-236 662.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_924030_1 313595.P700755_002137 1.83e-39 148.0 COG4467@1|root,COG4467@2|Bacteria,4NV1D@976|Bacteroidetes,1I9SU@117743|Flavobacteriia 976|Bacteroidetes S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_825407_1 1385517.N800_14285 1.07e-16 81.6 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1RQUV@1236|Gammaproteobacteria,1X4AA@135614|Xanthomonadales 135614|Xanthomonadales T phosphatase - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_301695_1 1168034.FH5T_04170 7.24e-250 726.0 COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,2FMWR@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_368148_1 1165841.SULAR_02493 5.21e-32 118.0 2AK26@1|root,31ART@2|Bacteria,1Q60M@1224|Proteobacteria,432MI@68525|delta/epsilon subdivisions,2YSKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_726991_2 330214.NIDE0126 3.21e-06 52.8 2CFYD@1|root,2Z81N@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_335928_1 572477.Alvin_1664 9.82e-55 177.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,1WYNA@135613|Chromatiales 135613|Chromatiales S Belongs to the CinA family - - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_268880_2 1123261.AXDW01000004_gene2709 2.05e-80 251.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1X2YM@135614|Xanthomonadales 135614|Xanthomonadales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_73944_1 1484479.DI14_10080 4.37e-58 197.0 COG1231@1|root,COG1231@2|Bacteria,1UZBA@1239|Firmicutes,4HC4Q@91061|Bacilli 91061|Bacilli E Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_301701_1 338969.Rfer_2326 1.28e-46 161.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2VIXA@28216|Betaproteobacteria,4ABBP@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM polar amino acid ABC transporter, inner membrane subunit aapM - - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_301701_2 1408164.MOLA814_01947 3.82e-13 68.2 COG4597@1|root,COG4597@2|Bacteria 2|Bacteria P amino acid transport - - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_400119_1 1168034.FH5T_18240 1.53e-65 213.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,2FMBN@200643|Bacteroidia 976|Bacteroidetes I Biotin carboxylase accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K01965 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_39742_2 906968.Trebr_0222 1.79e-48 162.0 COG1853@1|root,COG1853@2|Bacteria,2J8D2@203691|Spirochaetes 203691|Spirochaetes S COGs COG1853 Conserved protein domain typically associated with flavoprotein oxygenase DIM6 NTAB family - - - - - - - - - - - - Flavin_Reduct k59_955640_1 1230342.CTM_15053 3.83e-05 51.2 COG0834@1|root,COG3437@1|root,COG0834@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GGDEF,HD_5,PAS,PAS_4,SBP_bac_3 k59_237035_1 1537917.JU82_09575 2.62e-94 278.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,42MPW@68525|delta/epsilon subdivisions,2YMU6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_237035_2 709032.Sulku_0190 1.1e-101 298.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2YMFG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J ribosomal protein L3 rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_400124_1 1116369.KB890024_gene4706 3.47e-39 137.0 COG5456@1|root,COG5456@2|Bacteria,1N5J5@1224|Proteobacteria,2UC8D@28211|Alphaproteobacteria,43KAD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P integral membrane protein linked to a cation pump fixH - - - - - - - - - - - FixH k59_629649_1 713586.KB900536_gene1384 1.75e-79 261.0 COG2199@1|root,COG3221@1|root,COG3221@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1SZ0G@1236|Gammaproteobacteria 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_629649_2 1537917.JU82_01510 1.46e-41 142.0 COG2227@1|root,COG2227@2|Bacteria,1QYD8@1224|Proteobacteria,43CBI@68525|delta/epsilon subdivisions,2YTHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Ribosomal RNA adenine dimethylase - - - - - - - - - - - - Methyltransf_25 k59_237036_1 686340.Metal_3507 4.46e-52 179.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1XERH@135618|Methylococcales 135618|Methylococcales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_335951_2 1123371.ATXH01000018_gene1381 7.5e-05 46.6 COG0823@1|root,COG0823@2|Bacteria,2GHJ5@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_727012_1 985255.APHJ01000018_gene2985 2.16e-51 175.0 COG0598@1|root,COG0598@2|Bacteria,4NG3C@976|Bacteroidetes,1HXRX@117743|Flavobacteriia,2P5MW@244698|Gillisia 976|Bacteroidetes P CorA-like Mg2+ transporter protein corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_39754_1 56110.Oscil6304_2863 6.68e-12 66.2 COG1971@1|root,COG1971@2|Bacteria,1G66H@1117|Cyanobacteria,1HBEK@1150|Oscillatoriales 1117|Cyanobacteria P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp k59_564376_1 56107.Cylst_4665 2.65e-37 144.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2204@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2204@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HIE5@1161|Nostocales 1117|Cyanobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg k59_989026_1 865937.Gilli_0010 2.81e-69 224.0 COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,1HY1D@117743|Flavobacteriia,2P5FE@244698|Gillisia 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_989026_2 391616.OA238_c40150 6.34e-86 273.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_924081_1 498761.HM1_0138 1.66e-13 76.3 COG4733@1|root,COG5492@1|root,COG4733@2|Bacteria,COG5492@2|Bacteria,1UHXK@1239|Firmicutes,25E6U@186801|Clostridia 186801|Clostridia N S-layer homology domain - - - - - - - - - - - - Big_2,CBM_X2,Flg_new,I-set,Laminin_G_3,SLH k59_466300_1 349521.HCH_01116 3.48e-68 225.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1XHDI@135619|Oceanospirillales 135619|Oceanospirillales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_791403_1 1144275.COCOR_02763 7.79e-41 149.0 COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMQ@68525|delta/epsilon subdivisions,2X6ZS@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_759680_1 722419.PH505_au00260 8.77e-84 273.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,2PZGC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_694767_1 686340.Metal_2280 1.46e-164 471.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1XEEH@135618|Methylococcales 135618|Methylococcales F TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_564398_1 56780.SYN_00309 5.3e-72 229.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MQ8D@213462|Syntrophobacterales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1021573_1 1123239.KB898632_gene2200 3.22e-11 69.7 COG4974@1|root,COG4974@2|Bacteria,1V0KQ@1239|Firmicutes,4HDPQ@91061|Bacilli 91061|Bacilli L Belongs to the 'phage' integrase family xerS GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - - - - - - - - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_596667_2 572544.Ilyop_0968 4.06e-39 135.0 COG1622@1|root,COG1622@2|Bacteria,37CJY@32066|Fusobacteria 2|Bacteria C cytochrome c oxidase subunit II - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1 k59_596667_3 572544.Ilyop_2830 3.19e-101 296.0 COG2128@1|root,COG2128@2|Bacteria 2|Bacteria S hydroperoxide reductase activity ynjA - - ko:K07486 - - - - ko00000 - - - CMD k59_596667_4 572544.Ilyop_2833 0.0 924.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase copA - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_596667_5 865937.Gilli_3289 1.27e-10 58.5 COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,1I2XY@117743|Flavobacteriia,2P6Z2@244698|Gillisia 976|Bacteroidetes S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_499144_1 1121481.AUAS01000009_gene73 1.2e-51 186.0 COG5434@1|root,COG5434@2|Bacteria,4NE4H@976|Bacteroidetes,47NFA@768503|Cytophagia 976|Bacteroidetes M Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - - k59_204553_1 1052684.PPM_3217 6.94e-28 119.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_791412_1 443143.GM18_1921 4.62e-24 99.4 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42R18@68525|delta/epsilon subdivisions,2WN0H@28221|Deltaproteobacteria,43UH3@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 3.1.11.2,4.2.99.18 ko:K01142,ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,Exo_endo_phos,HhH-GPD k59_1021585_1 326298.Suden_1104 1.19e-33 125.0 COG4786@1|root,COG4786@2|Bacteria,1PZ24@1224|Proteobacteria,42NGI@68525|delta/epsilon subdivisions,2YNFE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar basal body flgG2 - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1021585_2 929558.SMGD1_2730 6.58e-101 298.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,42N3R@68525|delta/epsilon subdivisions,2YMWT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Belongs to the flagella basal body rod proteins family flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_564416_1 1458275.AZ34_14670 7.25e-47 170.0 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,4ACXX@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23,HlyD_D4 k59_727063_1 1235803.C825_02373 1.39e-21 94.4 COG2259@1|root,COG2259@2|Bacteria,4NGNF@976|Bacteroidetes,2G2Z3@200643|Bacteroidia,22W11@171551|Porphyromonadaceae 976|Bacteroidetes S DoxX family - - - - - - - - - - - - DoxX k59_727063_2 1168034.FH5T_21045 1.31e-35 127.0 COG0149@1|root,COG0149@2|Bacteria,4NE2F@976|Bacteroidetes,2FNEK@200643|Bacteroidia 976|Bacteroidetes G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_74038_1 1121405.dsmv_1475 1e-51 181.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2WJ23@28221|Deltaproteobacteria,2MHTD@213118|Desulfobacterales 28221|Deltaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_663271_1 56780.SYN_01486 9.16e-39 140.0 COG0791@1|root,COG3087@1|root,COG0791@2|Bacteria,COG3087@2|Bacteria,1N0EE@1224|Proteobacteria,42V3C@68525|delta/epsilon subdivisions,2WRIP@28221|Deltaproteobacteria,2MSJ0@213462|Syntrophobacterales 28221|Deltaproteobacteria M NlpC/P60 family - - - - - - - - - - - - NLPC_P60,SPOR k59_433055_1 1168034.FH5T_10220 1.19e-143 412.0 COG0226@1|root,COG0226@2|Bacteria,4NHAS@976|Bacteroidetes,2FQFA@200643|Bacteroidia 976|Bacteroidetes P Belongs to the PstS family pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_172847_1 631362.Thi970DRAFT_04087 2.27e-183 521.0 COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,1RMJT@1236|Gammaproteobacteria,1WWC2@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation sthA - 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_140521_1 1144313.PMI10_00482 1.64e-62 218.0 COG4677@1|root,COG4677@2|Bacteria,4PNFN@976|Bacteroidetes,1I0J5@117743|Flavobacteriia,2P0UZ@237|Flavobacterium 976|Bacteroidetes G pectinesterase activity - - - - - - - - - - - - Pectinesterase,TSP_3 k59_336693_1 43179.ENSSTOP00000010535 8.72e-32 129.0 COG3119@1|root,KOG3867@2759|Eukaryota,38CRA@33154|Opisthokonta,3BGPB@33208|Metazoa,3CTVU@33213|Bilateria,48564@7711|Chordata,48XC5@7742|Vertebrata,3JEM7@40674|Mammalia,35JBY@314146|Euarchontoglires,4PYB4@9989|Rodentia 33208|Metazoa P Sulfatase IDS GO:0000323,GO:0003674,GO:0003824,GO:0004423,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0005775,GO:0006022,GO:0006026,GO:0006027,GO:0006029,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008484,GO:0009056,GO:0009057,GO:0009100,GO:0009987,GO:0016787,GO:0016788,GO:0019538,GO:0030203,GO:0030204,GO:0030207,GO:0031974,GO:0043170,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044273,GO:0044281,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0050654,GO:0070013,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903510 3.1.6.13 ko:K01136 ko00531,ko01100,ko04142,map00531,map01100,map04142 M00076,M00078 R07812,R07821 - ko00000,ko00001,ko00002,ko01000 - - - Sulfatase k59_74734_1 1408287.AXUR01000026_gene102 4.17e-46 165.0 COG0846@1|root,COG0846@2|Bacteria 2|Bacteria K NAD+ binding - - - - - - - - - - - - SIR2_2 k59_602326_1 387093.SUN_2227 8.5e-115 347.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2YM9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase - - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 k59_1025951_1 679937.Bcop_2390 9.56e-50 179.0 COG0770@1|root,COG0787@1|root,COG0770@2|Bacteria,COG0787@2|Bacteria,4NEXM@976|Bacteroidetes,2FMM3@200643|Bacteroidia,4AK9Q@815|Bacteroidaceae 976|Bacteroidetes M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N,Mur_ligase,Mur_ligase_M k59_896043_1 349102.Rsph17025_0799 4.49e-108 319.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L hmm pf01609 - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_210135_1 1168034.FH5T_04160 1.39e-27 106.0 COG2086@1|root,COG2086@2|Bacteria,4NFWB@976|Bacteroidetes,2FMG3@200643|Bacteroidia 976|Bacteroidetes C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_437403_1 1168065.DOK_13214 7.99e-169 492.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1J4QN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009436,GO:0009987,GO:0015980,GO:0016054,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:1901575 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - iECSF_1327.ECSF_2799,iECW_1372.ECW_m3242,iEKO11_1354.EKO11_0745,iJN746.PP_0356,iWFL_1372.ECW_m3242 Malate_synthase k59_341499_1 545697.HMPREF0216_00186 1.4e-26 110.0 COG1216@1|root,COG1216@2|Bacteria,1V5AQ@1239|Firmicutes,24IBY@186801|Clostridia,36KV3@31979|Clostridiaceae 186801|Clostridia S Glycosyltransferase, group 2 family protein - - - ko:K12990 ko02024,ko02025,map02024,map02025 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_2 k59_273340_1 1122603.ATVI01000008_gene2234 6.01e-40 137.0 COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1X5XX@135614|Xanthomonadales 135614|Xanthomonadales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length greB - - ko:K04760 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_273340_2 754477.Q7C_2134 1.16e-18 83.6 2BVTQ@1|root,2Z7J9@2|Bacteria,1P01Z@1224|Proteobacteria,1RNNB@1236|Gammaproteobacteria,4603Z@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF2797) - - - - - - - - - - - - DUF2797 k59_111530_1 742738.HMPREF9460_00687 8.14e-42 149.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,268FV@186813|unclassified Clostridiales 186801|Clostridia I Acyl-CoA dehydrogenase, C-terminal domain bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_111530_2 929506.CbC4_1949 1.48e-315 877.0 COG3962@1|root,COG3962@2|Bacteria,1UI18@1239|Firmicutes,25EA8@186801|Clostridia,36UJU@31979|Clostridiaceae 186801|Clostridia E Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) iolD - 3.7.1.22 ko:K03336 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08603 RC02331 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_537245_1 795666.MW7_2373 5.31e-27 111.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2VNA4@28216|Betaproteobacteria,1K6DJ@119060|Burkholderiaceae 28216|Betaproteobacteria H Aminotransferase class I and II jqsA - - ko:K10915 ko02024,ko05111,map02024,map05111 - - - ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_994416_1 1049564.TevJSym_ag00620 4.04e-42 142.0 COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1SBVN@1236|Gammaproteobacteria,1JBWS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Bacterial DNA-binding protein hup - - - - - - - - - - - Bac_DNA_binding k59_341506_1 929558.SMGD1_1950 6.84e-95 291.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2YMZG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_44296_1 1433126.BN938_2081 3.36e-13 69.3 COG2825@1|root,COG2825@2|Bacteria,4NSCM@976|Bacteroidetes,2FT3P@200643|Bacteroidia,22UIQ@171550|Rikenellaceae 976|Bacteroidetes M Outer membrane protein (OmpH-like) ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_44296_2 172045.KS04_01650 3.12e-41 144.0 COG0796@1|root,COG0796@2|Bacteria,4NG1C@976|Bacteroidetes,1HX4S@117743|Flavobacteriia,34QRA@308865|Elizabethkingia 976|Bacteroidetes M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_241943_1 159087.Daro_0237 3.16e-57 192.0 COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,2VHU2@28216|Betaproteobacteria,2KYQW@206389|Rhodocyclales 206389|Rhodocyclales C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_470482_1 1168034.FH5T_10310 6.85e-154 464.0 COG1413@1|root,COG1413@2|Bacteria,4NEZ7@976|Bacteroidetes,2FPRF@200643|Bacteroidia 976|Bacteroidetes C Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080,HEAT_2 k59_537249_1 460265.Mnod_7596 4.07e-88 272.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria,1JQUY@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_437414_1 1304880.JAGB01000001_gene369 1.09e-46 172.0 COG3250@1|root,COG3250@2|Bacteria,1TRQF@1239|Firmicutes,248UC@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - Glyco_hydro_106 k59_1025967_1 305700.B447_05660 2.62e-18 90.5 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,2KUKQ@206389|Rhodocyclales 206389|Rhodocyclales S protein containing LysM domain - - - - - - - - - - - - LysM k59_830410_1 1255043.TVNIR_0090 2.39e-42 153.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1WXMK@135613|Chromatiales 135613|Chromatiales S Polyphosphate AMP phosphotransferase - - - - - - - - - - - - PPK2 k59_830410_2 1163617.SCD_n02191 3.12e-16 77.4 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria 28216|Betaproteobacteria S Aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_505029_1 665942.HMPREF1022_03238 2.23e-123 363.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria,2M7SQ@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family capL - 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 - R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_177696_1 1357399.HMPREF2087_00933 9.93e-31 125.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2YNM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T ATPase related to phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_78708_2 1408473.JHXO01000014_gene4075 1.11e-63 212.0 COG0441@1|root,COG0441@2|Bacteria,4NEFT@976|Bacteroidetes,2FMAU@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_111545_2 1168034.FH5T_00065 1.64e-24 98.2 COG1208@1|root,COG1208@2|Bacteria,4NMJ5@976|Bacteroidetes,2FNEE@200643|Bacteroidia 976|Bacteroidetes JM Nucleotidyl transferase hddC - - - - - - - - - - - NTP_transferase k59_1025975_1 208444.JNYY01000001_gene4716 1.66e-24 105.0 28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria,4E6WC@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_994431_1 1408473.JHXO01000008_gene2714 1.57e-26 102.0 COG1846@1|root,COG1846@2|Bacteria,4NRNH@976|Bacteroidetes 976|Bacteroidetes K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k59_994431_2 980584.AFPB01000147_gene1289 6.75e-26 106.0 COG3387@1|root,COG3387@2|Bacteria,4NEE6@976|Bacteroidetes,1HY70@117743|Flavobacteriia 976|Bacteroidetes G COG3387 Glucoamylase and related glycosyl - - 3.2.1.3 ko:K01178 ko00500,ko01100,map00500,map01100 - R01790,R01791,R06199 - ko00000,ko00001,ko01000 - GH15 - Glyco_hydro_15 k59_569339_1 572480.Arnit_2682 5.74e-07 47.8 2EKKG@1|root,33EAB@2|Bacteria,1PAFB@1224|Proteobacteria,42XD1@68525|delta/epsilon subdivisions,2YQY5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_569339_3 760154.Sulba_1598 6.15e-70 231.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M0P@68525|delta/epsilon subdivisions,2YMU0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P heavy metal translocating P-type ATPase - - - - - - - - - - - - E1-E2_ATPase,Hydrolase k59_306671_1 1168034.FH5T_01550 3.84e-88 277.0 COG1520@1|root,COG1520@2|Bacteria,4P1VG@976|Bacteroidetes,2FW8D@200643|Bacteroidia 976|Bacteroidetes S PQQ-like domain - - - - - - - - - - - - PQQ_2 k59_177699_1 338966.Ppro_3583 8.23e-27 109.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria,43UBP@69541|Desulfuromonadales 28221|Deltaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_177699_2 1201290.M902_2586 8.44e-05 47.0 COG1651@1|root,COG1651@2|Bacteria,1NZPQ@1224|Proteobacteria,42U1T@68525|delta/epsilon subdivisions,2MSXR@213481|Bdellovibrionales,2WQH9@28221|Deltaproteobacteria 213481|Bdellovibrionales O PFAM DSBA oxidoreductase - - - - - - - - - - - - Thioredoxin_4 k59_731402_1 323848.Nmul_A2131 1.63e-46 160.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,372A8@32003|Nitrosomonadales 28216|Betaproteobacteria NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_929308_1 1121937.AUHJ01000036_gene2809 2.22e-112 335.0 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,1RRWS@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_929308_2 1121937.AUHJ01000036_gene2810 2.18e-20 87.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,4658U@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG3267 Type II secretory pathway, component ExeA - - - - - - - - - - - - AAA_22 k59_470498_1 1168034.FH5T_19100 6.1e-35 135.0 COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,4NI98@976|Bacteroidetes,2FPEX@200643|Bacteroidia 976|Bacteroidetes KT SpoIIE domain protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,HATPase_c_2,SpoIIE,dCache_1 k59_210171_1 929558.SMGD1_2447 2.03e-81 268.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2YMQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_177703_1 857087.Metme_0617 1.04e-26 116.0 COG0419@1|root,COG3264@1|root,COG0419@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales 135618|Methylococcales M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM,MscS_porin k59_994436_1 1121405.dsmv_3151 3.21e-52 189.0 COG0699@1|root,COG0699@2|Bacteria,1R3WJ@1224|Proteobacteria,42N0G@68525|delta/epsilon subdivisions,2WKFJ@28221|Deltaproteobacteria,2MJ5I@213118|Desulfobacterales 28221|Deltaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_1025987_1 269796.Rru_A1622 7.13e-28 111.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2U1PX@28211|Alphaproteobacteria,2JRDE@204441|Rhodospirillales 204441|Rhodospirillales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_406004_1 204669.Acid345_2295 6.38e-61 203.0 COG2252@1|root,COG2252@2|Bacteria,3Y2I3@57723|Acidobacteria,2JIGY@204432|Acidobacteriia 204432|Acidobacteriia S Permease family - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k59_210975_1 385682.AFSL01000003_gene1942 4.23e-35 130.0 COG2264@1|root,COG2264@2|Bacteria,4NFRW@976|Bacteroidetes,2FP0Q@200643|Bacteroidia,3XJZX@558415|Marinilabiliaceae 976|Bacteroidetes J Ribosomal protein L11 methyltransferase (PrmA) prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_961918_2 472759.Nhal_3318 1.45e-50 176.0 COG4424@1|root,COG4424@2|Bacteria,1N77D@1224|Proteobacteria,1SB49@1236|Gammaproteobacteria,1WZDB@135613|Chromatiales 135613|Chromatiales S PFAM sulfotransferase - - - - - - - - - - - - Sulfotransfer_3 k59_538030_2 1168034.FH5T_00115 8.5e-66 203.0 COG5015@1|root,COG5015@2|Bacteria,4P5J8@976|Bacteroidetes,2FW0K@200643|Bacteroidia 976|Bacteroidetes S Pyridoxamine 5'-phosphate oxidase - - - - - - - - - - - - Putative_PNPOx k59_603201_1 589924.Ferp_1257 7.57e-51 182.0 COG0243@1|root,COG1153@1|root,arCOG01495@2157|Archaea,arCOG02674@2157|Archaea,2Y8AD@28890|Euryarchaeota 28890|Euryarchaeota C Molybdopterin oxidoreductase - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_373777_1 1120968.AUBX01000014_gene2511 4.15e-48 167.0 COG1609@1|root,COG1609@2|Bacteria,4NFB7@976|Bacteroidetes,47JAA@768503|Cytophagia 976|Bacteroidetes K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR,Peripla_BP_3 k59_210982_1 56780.SYN_02069 2.95e-52 172.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2MQ9V@213462|Syntrophobacterales 28221|Deltaproteobacteria Q ABC-type transport system involved in resistance to organic solvents, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_210982_2 1122604.JONR01000007_gene2816 2.41e-12 67.0 COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,1S6SW@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q MlaD protein - - - ko:K06192 - - - - ko00000 - - - MlaD k59_831186_1 95619.PM1_0216590 2.18e-17 81.6 COG0025@1|root,COG1226@1|root,COG0025@2|Bacteria,COG1226@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family nhaP - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,TrkA_N k59_831186_2 1504672.669784767 1.98e-111 332.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,4A9SH@80864|Comamonadaceae 28216|Betaproteobacteria C NADH flavin oxidoreductase NADH oxidase - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_603205_1 1278307.KB907025_gene744 2.62e-26 103.0 COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,1S6T4@1236|Gammaproteobacteria,2QJ1I@267894|Psychromonadaceae 1236|Gammaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_373787_1 545264.KB898746_gene695 9.04e-72 231.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales 135613|Chromatiales T SMART Nucleotide binding protein, PINc - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_79293_2 383372.Rcas_0601 0.000751 43.5 COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi,3753C@32061|Chloroflexia 32061|Chloroflexia L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_831193_1 391937.NA2_02284 2.05e-34 129.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,43H44@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_831193_2 713586.KB900536_gene2838 7.51e-42 144.0 COG1249@1|root,COG1249@2|Bacteria 2|Bacteria C cell redox homeostasis - - 4.99.1.2 ko:K00221 - - - - ko00000,ko01000 - - - MerB k59_700513_1 1121448.DGI_0306 2.66e-130 385.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process - - - - - - - - - - - - Beta_helix,DUF1565,SLH k59_603217_1 1165841.SULAR_01588 1.3e-24 95.5 COG1254@1|root,COG1254@2|Bacteria,1Q88S@1224|Proteobacteria,42WDB@68525|delta/epsilon subdivisions,2YQCS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the acylphosphatase family - - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_603217_2 749222.Nitsa_1249 1.99e-27 100.0 2AKC8@1|root,31B36@2|Bacteria,1Q6TQ@1224|Proteobacteria,433T1@68525|delta/epsilon subdivisions,2YSPZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_438188_1 709032.Sulku_0488 9.44e-138 410.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2YMKH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_995211_1 765913.ThidrDRAFT_4109 1.11e-24 98.6 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1WZFD@135613|Chromatiales 135613|Chromatiales U PFAM Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_307484_1 1049564.TevJSym_bj00010 9.35e-55 185.0 COG0665@1|root,COG0665@2|Bacteria,1Q8AY@1224|Proteobacteria,1RSC9@1236|Gammaproteobacteria,1JC30@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_406023_2 413404.Rmag_0637 1.08e-64 207.0 COG4912@1|root,COG4912@2|Bacteria,1QJE1@1224|Proteobacteria,1S2U6@1236|Gammaproteobacteria,1JATV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA alkylation repair enzyme - - - - - - - - - - - - DNA_alkylation k59_863355_1 3983.cassava4.1_024533m 2.88e-48 168.0 28JZI@1|root,2QSDY@2759|Eukaryota,37J4T@33090|Viridiplantae,3GC2Z@35493|Streptophyta,4JREA@91835|fabids 35493|Streptophyta U Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope ycf1 - - - - - - - - - - - Ycf1 k59_373795_1 469618.FVAG_01506 6.53e-06 46.6 COG1302@1|root,COG1302@2|Bacteria,37AEJ@32066|Fusobacteria 32066|Fusobacteria S Asp23 family, cell envelope-related function - - - - - - - - - - - - Asp23 k59_373795_2 572544.Ilyop_1468 8.63e-40 140.0 28PMX@1|root,2ZCAR@2|Bacteria,379XU@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_406028_1 472759.Nhal_3421 3.64e-80 249.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1WXVZ@135613|Chromatiales 135613|Chromatiales C Belongs to the AlaDH PNT family - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_961952_1 863365.XHC_0723 1.35e-75 239.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1X3US@135614|Xanthomonadales 135614|Xanthomonadales NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_732132_1 1121012.AUKX01000078_gene8 8.26e-67 223.0 COG3547@1|root,COG3547@2|Bacteria,4NGED@976|Bacteroidetes,1HYRZ@117743|Flavobacteriia,23ID0@178469|Arenibacter 976|Bacteroidetes L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_307491_1 998674.ATTE01000001_gene511 1.84e-35 132.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,4601Y@72273|Thiotrichales 72273|Thiotrichales F Belongs to the GARS family purD - 6.3.2.6,6.3.4.13 ko:K01945,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N,SAICAR_synt k59_995216_1 1227349.C170_13205 4.8e-83 253.0 COG1940@1|root,COG1940@2|Bacteria,1TQU4@1239|Firmicutes,4HA1C@91061|Bacilli,26SF1@186822|Paenibacillaceae 91061|Bacilli GK fructokinase gmuE - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - ROK k59_995216_2 996637.SGM_2866 8.05e-09 59.3 COG1172@1|root,COG1879@1|root,COG1172@2|Bacteria,COG1879@2|Bacteria,2GJDW@201174|Actinobacteria 201174|Actinobacteria G Belongs to the binding-protein-dependent transport system permease family rbsC - - ko:K10439,ko:K10440 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2,Peripla_BP_4 k59_112242_1 1283300.ATXB01000001_gene405 9.69e-17 79.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1XEWQ@135618|Methylococcales 135618|Methylococcales S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_112242_2 713586.KB900536_gene1344 8.51e-93 281.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1WWBW@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_635754_1 1168034.FH5T_05140 7.51e-110 320.0 COG4912@1|root,COG4912@2|Bacteria,4NUAZ@976|Bacteroidetes,2FQ8F@200643|Bacteroidia 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DNA_alkylation k59_538065_1 1279017.AQYJ01000029_gene3960 1.62e-60 207.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_771027_2 3649.evm.model.supercontig_30.79 4.51e-63 197.0 COG0711@1|root,2S22I@2759|Eukaryota,37V28@33090|Viridiplantae,3GJTX@35493|Streptophyta,3I057@3699|Brassicales 35493|Streptophyta C ATP synthase B/B' CF(0) atpF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009719,GO:0009725,GO:0009735,GO:0010033,GO:0016020,GO:0031976,GO:0031984,GO:0034357,GO:0042221,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0055035 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_737179_1 376686.Fjoh_4216 1.1e-53 179.0 COG0697@1|root,2Z7ID@2|Bacteria,4NEHB@976|Bacteroidetes,1HZTB@117743|Flavobacteriia,2NT4R@237|Flavobacterium 976|Bacteroidetes EG Sugar proton symporter rhaT - - ko:K02856 - - - - ko00000,ko02000 2.A.7.6 - - RhaT k59_737179_2 504487.JCM19302_2072 2.36e-51 164.0 COG3254@1|root,COG3254@2|Bacteria,4NSEM@976|Bacteroidetes,1I4MI@117743|Flavobacteriia 976|Bacteroidetes G Involved in the anomeric conversion of L-rhamnose rhaU - 5.1.3.32 ko:K03534 - - R10819 RC00563 ko00000,ko01000 - - - rhaM k59_737179_3 1168034.FH5T_01030 3.74e-80 248.0 COG4806@1|root,COG4806@2|Bacteria,4NHKW@976|Bacteroidetes,2FNVS@200643|Bacteroidia 976|Bacteroidetes G Psort location Cytoplasmic, score 8.96 rhaA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008740,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.14 ko:K01813 ko00051,ko01120,map00051,map01120 - R02437 RC00434 ko00000,ko00001,ko01000 - - - RhaA k59_934943_1 1174504.AJTN02000176_gene2072 2.44e-06 47.4 2DR8Z@1|root,33AQV@2|Bacteria,1VK7N@1239|Firmicutes,4IDP9@91061|Bacilli,1ZNDA@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_84537_1 1565314.OA34_04080 2.33e-63 206.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2YMCS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_84537_2 563040.Saut_0303 5.49e-34 129.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2YMEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_706540_1 472759.Nhal_1652 3.39e-65 216.0 COG1538@1|root,COG1538@2|Bacteria,1NEZC@1224|Proteobacteria,1S1F9@1236|Gammaproteobacteria,1X1BJ@135613|Chromatiales 135613|Chromatiales MU PFAM Outer membrane efflux protein - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP k59_348223_1 1168034.FH5T_04005 6.62e-56 184.0 COG1995@1|root,COG1995@2|Bacteria,4NEUR@976|Bacteroidetes,2FN0X@200643|Bacteroidia 976|Bacteroidetes C Belongs to the PdxA family pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_348223_2 908612.HMPREF9720_2782 1.64e-26 102.0 COG0632@1|root,COG0632@2|Bacteria,4NF4E@976|Bacteroidetes,2FNA8@200643|Bacteroidia,22VBJ@171550|Rikenellaceae 976|Bacteroidetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_477126_1 1121296.JONJ01000004_gene1007 1.03e-09 59.7 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,21Z1B@1506553|Lachnoclostridium 186801|Clostridia J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_477126_2 472175.EL18_03218 1.68e-15 76.6 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2U78A@28211|Alphaproteobacteria,43IJ0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S DedA family dedA - - - - - - - - - - - SNARE_assoc k59_118335_1 96561.Dole_3138 6.96e-07 55.1 COG5340@1|root,COG5340@2|Bacteria,1P6MT@1224|Proteobacteria,42SXD@68525|delta/epsilon subdivisions,2WP1U@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Transcriptional regulator, AbiEi antitoxin - - - - - - - - - - - - AbiEi_4 k59_674795_1 1429851.X548_18210 8.74e-71 221.0 COG4555@1|root,COG4555@2|Bacteria,1QU2T@1224|Proteobacteria,1RY2V@1236|Gammaproteobacteria,1X307@135614|Xanthomonadales 135614|Xanthomonadales CP abc transporter atp-binding protein - - 3.6.3.7 ko:K09697 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.115 - - ABC_tran k59_1001095_1 929558.SMGD1_2188 1.96e-07 51.2 COG0579@1|root,COG0579@2|Bacteria,1MUCC@1224|Proteobacteria,42M2Q@68525|delta/epsilon subdivisions,2YMYG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Malate quinone- oxidoreductase mqo GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.5.4 ko:K00116 ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R00360,R00361,R01257 RC00031 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0086 Mqo k59_1001095_2 1249480.B649_00095 3.93e-76 234.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42PA1@68525|delta/epsilon subdivisions,2YNMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_348238_2 1304888.ATWF01000001_gene2193 3.75e-07 54.7 COG4567@1|root,COG4567@2|Bacteria,2GGD8@200930|Deferribacteres 200930|Deferribacteres T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg k59_217025_1 742726.HMPREF9448_00527 1.08e-28 115.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FM37@200643|Bacteroidia,22W2S@171551|Porphyromonadaceae 976|Bacteroidetes P TonB-dependent Receptor Plug Domain ragA - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_217025_2 411479.BACUNI_01092 1.36e-09 62.8 COG0446@1|root,COG0446@2|Bacteria,4PM76@976|Bacteroidetes,2FTT1@200643|Bacteroidia,4ASD7@815|Bacteroidaceae 976|Bacteroidetes S Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_151906_1 306263.Cla_a018 4.45e-96 293.0 COG2948@1|root,COG2948@2|Bacteria,1MXVX@1224|Proteobacteria,42MRP@68525|delta/epsilon subdivisions,2YN83@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Bacterial conjugation TrbI-like protein - - - ko:K03195 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - TrbI k59_151906_2 683083.C414_000160000 6.06e-147 424.0 COG0630@1|root,COG0630@2|Bacteria,1QUJ6@1224|Proteobacteria,43BJE@68525|delta/epsilon subdivisions,2YN60@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis - - - ko:K03196 ko03070,ko05120,map03070,map05120 M00333,M00564 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T2SSE k59_248660_1 4896.SPAC20G8.04c.1 3.06e-47 171.0 COG2440@1|root,KOG2415@2759|Eukaryota,38H8R@33154|Opisthokonta,3NY0G@4751|Fungi,3QQD7@4890|Ascomycota,3MDRD@451866|Taphrinomycotina 4751|Fungi C Electron transfer flavoprotein-ubiquinone oxidoreductase - GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0006116,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019362,GO:0019637,GO:0019674,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0046483,GO:0046496,GO:0048037,GO:0048038,GO:0048039,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0070013,GO:0071704,GO:0072524,GO:0098573,GO:0098798,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_348252_1 1121875.KB907547_gene2908 1.62e-43 162.0 COG0834@1|root,COG2172@1|root,COG2208@1|root,COG3829@1|root,COG0834@2|Bacteria,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3829@2|Bacteria,4PPGD@976|Bacteroidetes 976|Bacteroidetes T PAS domain - - - - - - - - - - - - - k59_641670_1 205922.Pfl01_4873 9.78e-17 77.8 COG0782@1|root,COG0782@2|Bacteria,1RHU5@1224|Proteobacteria,1SB59@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Elongation factor greB2 - - - - - - - - - - - GreA_GreB k59_348264_1 391613.RTM1035_08024 4.77e-27 108.0 COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,46P2E@74030|Roseovarius 28211|Alphaproteobacteria M Mitochondrial fission ELM1 - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_348264_2 1288298.rosmuc_01635 1.12e-29 113.0 COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,2U2U3@28211|Alphaproteobacteria,46PDN@74030|Roseovarius 28211|Alphaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_641683_2 1459636.NTE_03552 1.61e-12 67.0 COG0123@1|root,arCOG00324@2157|Archaea 2157|Archaea BQ including yeast histone deacetylase and acetoin utilization protein - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_869367_1 1168034.FH5T_07850 5.25e-97 296.0 COG2244@1|root,COG2244@2|Bacteria,4NDZ0@976|Bacteroidetes,2FKYU@200643|Bacteroidia 976|Bacteroidetes S Polysaccharide biosynthesis protein cap - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_576088_1 243231.GSU2533 1.22e-38 143.0 COG3203@1|root,COG3203@2|Bacteria,1PJNW@1224|Proteobacteria,42TCM@68525|delta/epsilon subdivisions,2WPPQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_837101_1 43989.cce_3823 5.26e-23 100.0 COG0628@1|root,COG0628@2|Bacteria,1G26W@1117|Cyanobacteria,3KG14@43988|Cyanothece 1117|Cyanobacteria S Pfam:UPF0118 - - - - - - - - - - - - AI-2E_transport k59_869374_1 1049564.TevJSym_aw00480 4.68e-82 249.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1J5PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_869374_2 1049564.TevJSym_aw00490 4.72e-62 199.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RMZ2@1236|Gammaproteobacteria,1J4GX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Belongs to the ParA family fleN - - ko:K04562 - - - - ko00000,ko02035 - - - ParA k59_935610_1 765913.ThidrDRAFT_1758 3.23e-51 164.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1WYHF@135613|Chromatiales 135613|Chromatiales J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_248675_1 1499684.CCNP01000020_gene2495 3.12e-64 206.0 COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia,36DQC@31979|Clostridiaceae 186801|Clostridia E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_737811_1 526222.Desal_0422 4.77e-53 184.0 COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,42PR4@68525|delta/epsilon subdivisions,2WJCN@28221|Deltaproteobacteria,2M7SG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Pfam:T6SS_VipB - - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF k59_411961_1 1458357.BG58_36745 3.9e-23 102.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,1K4Y9@119060|Burkholderiaceae 28216|Betaproteobacteria I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_217064_1 1379270.AUXF01000003_gene3412 6.09e-76 242.0 COG2211@1|root,COG2211@2|Bacteria,1ZV78@142182|Gemmatimonadetes 142182|Gemmatimonadetes G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_379726_1 439235.Dalk_3780 3.39e-76 243.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MIPI@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM carboxyl transferase - - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_50832_1 565034.BHWA1_00381 2.62e-52 179.0 COG1883@1|root,COG1883@2|Bacteria,2J61F@203691|Spirochaetes 203691|Spirochaetes C Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit - - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_706562_1 572544.Ilyop_1086 4.41e-92 299.0 COG1196@1|root,COG1196@2|Bacteria,37848@32066|Fusobacteria 32066|Fusobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_511820_1 580327.Tthe_1169 8.24e-31 120.0 COG0637@1|root,COG0637@2|Bacteria,1UHZ0@1239|Firmicutes,25E7J@186801|Clostridia,42GNN@68295|Thermoanaerobacterales 186801|Clostridia S PFAM haloacid - - - - - - - - - - - - HAD_2,Hydrolase k59_511824_1 32024.JMTI01000002_gene687 2.52e-16 79.7 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_511824_2 1244531.CIG1485E_1000 5.15e-13 70.5 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_968029_1 1123267.JONN01000001_gene1238 1.08e-65 225.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP k59_248703_1 1408473.JHXO01000006_gene1076 8.16e-94 288.0 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,2FNG7@200643|Bacteroidia 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_609127_2 563040.Saut_2139 6.55e-80 241.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2YMYI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_411981_1 519989.ECTPHS_06197 5.62e-11 67.8 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1SZ0N@1236|Gammaproteobacteria,1X2J4@135613|Chromatiales 135613|Chromatiales T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_674877_1 1349767.GJA_1877 1.94e-48 174.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2VHTT@28216|Betaproteobacteria,476KH@75682|Oxalobacteraceae 28216|Betaproteobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain f1pep1 - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_511833_1 1394175.AWUN01000005_gene87 1.47e-11 64.3 COG1136@1|root,COG1136@2|Bacteria,2GM25@201174|Actinobacteria,4CZZ4@85004|Bifidobacteriales 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_511833_2 572544.Ilyop_0510 6.3e-46 155.0 COG1544@1|root,COG1544@2|Bacteria,3795K@32066|Fusobacteria 32066|Fusobacteria J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE k59_543698_2 643867.Ftrac_3686 4.06e-30 119.0 COG2010@1|root,COG2010@2|Bacteria,4NF0A@976|Bacteroidetes,47J8Z@768503|Cytophagia 976|Bacteroidetes C PFAM Class III cytochrome C family actA - - - - - - - - - - - Cytochrom_C,Cytochrom_CIII,Cytochrome_C7 k59_279798_1 1049564.TevJSym_ar00460 1.88e-233 657.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1J589@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_279798_2 1049564.TevJSym_ar00470 2.87e-285 799.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1J4Z1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_279798_3 1049564.TevJSym_ar00480 3.24e-89 268.0 COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,1S9PP@1236|Gammaproteobacteria,1J6J0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_279798_4 1049564.TevJSym_ar00500 3.79e-60 193.0 28NN8@1|root,2ZBNM@2|Bacteria,1RC04@1224|Proteobacteria,1S2KF@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_279798_5 1049564.TevJSym_ar00490 0.0 1207.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1J5CM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_279798_6 765913.ThidrDRAFT_3393 2.24e-143 410.0 COG1432@1|root,COG1432@2|Bacteria,1PC2I@1224|Proteobacteria,1TIXS@1236|Gammaproteobacteria,1WXAE@135613|Chromatiales 135613|Chromatiales S NYN domain - - - - - - - - - - - - NYN k59_279798_7 351348.Maqu_2062 9.6e-291 831.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,469RS@72275|Alteromonadaceae 1236|Gammaproteobacteria S transport system, fused permease components - - - - - - - - - - - - DUF3394,DctM k59_279798_8 323259.Mhun_2415 9.23e-16 79.3 arCOG03377@1|root,arCOG03377@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - Trypsin k59_279798_9 1049564.TevJSym_ac01750 2.4e-176 494.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1J5NQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Polyphosphate kinase 2 (PPK2) ppk2 - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_279798_10 1307761.L21SP2_2330 8.02e-43 144.0 COG1832@1|root,COG1832@2|Bacteria 2|Bacteria S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_279798_11 1249627.D779_1436 4.92e-125 368.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1WW5X@135613|Chromatiales 135613|Chromatiales J Elongation factor P--(R)-beta-lysine ligase - - - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_279798_12 857087.Metme_3752 1.39e-111 323.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1XE5P@135618|Methylococcales 135618|Methylococcales J Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_279798_13 511062.GU3_05315 8.18e-100 303.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria 1236|Gammaproteobacteria C lysine 2,3-aminomutase epmB GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016866,GO:0016869,GO:0048037,GO:0051536,GO:0051539,GO:0051540 5.4.3.2 ko:K01843,ko:K19810 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000,ko03012 - - iECH74115_1262.ECH74115_5662,iECIAI39_1322.ECIAI39_4611,iS_1188.S4569 Fer4_12,Fer4_14,Radical_SAM k59_279798_14 1453503.AU05_20275 2e-59 216.0 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_279798_15 1049564.TevJSym_aj00730 3.21e-207 606.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1J4N6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_9,Response_reg k59_279798_16 472759.Nhal_2760 1.53e-145 418.0 2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,1RNI9@1236|Gammaproteobacteria,1WW9W@135613|Chromatiales 135613|Chromatiales S PFAM 5'-nucleotidase - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5-nucleotidase k59_279798_17 754476.Q7A_1251 5.25e-07 58.9 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,1RS25@1236|Gammaproteobacteria,460MD@72273|Thiotrichales 72273|Thiotrichales T HDOD domain - - - - - - - - - - - - EAL,HDOD k59_279798_18 1122176.KB903554_gene3954 3.13e-58 191.0 COG1051@1|root,COG1051@2|Bacteria,4NH28@976|Bacteroidetes,1IQBA@117747|Sphingobacteriia 976|Bacteroidetes F Belongs to the Nudix hydrolase family - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_279798_19 1049564.TevJSym_aa01850 8.53e-194 545.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1J56G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919 NadA k59_279798_20 1163617.SCD_n00461 4.54e-101 315.0 COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,2VNAW@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the heme-copper respiratory oxidase family - - - - - - - - - - - - - k59_279798_21 580332.Slit_1118 5.8e-08 52.8 COG0425@1|root,COG0425@2|Bacteria,1QU8C@1224|Proteobacteria,2WGIR@28216|Betaproteobacteria 28216|Betaproteobacteria O Uncharacterized conserved protein (DUF2249) - - - - - - - - - - - - DUF2249 k59_279798_22 292415.Tbd_2172 2.32e-47 157.0 COG2846@1|root,COG2846@2|Bacteria,1QX13@1224|Proteobacteria,2WH3K@28216|Betaproteobacteria,1KRV2@119069|Hydrogenophilales 119069|Hydrogenophilales D Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_279798_24 1172190.M947_07275 1.39e-151 443.0 COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,42P30@68525|delta/epsilon subdivisions,2YNT6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L radical SAM domain protein - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - k59_279798_25 203122.Sde_3365 1.99e-16 82.0 COG3152@1|root,COG3152@2|Bacteria,1N85G@1224|Proteobacteria,1SCMI@1236|Gammaproteobacteria,468P3@72275|Alteromonadaceae 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - - k59_279798_26 396588.Tgr7_0082 8.6e-143 449.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2QR@135613|Chromatiales 135613|Chromatiales T Histidine Phosphotransfer domain - - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg k59_279798_27 653733.Selin_0468 7.89e-63 208.0 COG0679@1|root,COG0679@2|Bacteria 2|Bacteria S auxin-activated signaling pathway - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_279798_28 765910.MARPU_02035 1.62e-245 695.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales 135613|Chromatiales P PFAM Na Picotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_279798_29 1454004.AW11_00035 4.87e-52 170.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - Usp k59_279798_30 1454004.AW11_00033 1.7e-190 541.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria 1224|Proteobacteria S CBS domain containing protein - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_279798_31 1454004.AW11_00034 1.29e-206 588.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria 1224|Proteobacteria S CBS domain containing protein - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_279798_34 1049564.TevJSym_aa01710 2.51e-46 150.0 2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,1S9N4@1236|Gammaproteobacteria,1JB6N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_279798_35 1167006.UWK_00156 2.7e-228 642.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,42Q6Y@68525|delta/epsilon subdivisions,2WJK0@28221|Deltaproteobacteria,2MI1Y@213118|Desulfobacterales 28221|Deltaproteobacteria L Exonuclease C-terminal - - 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_279798_36 1049564.TevJSym_aa01690 2.47e-55 174.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1J65P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_353272_1 485915.Dret_1473 2.73e-41 154.0 COG1629@1|root,COG4771@2|Bacteria,1MXY7@1224|Proteobacteria,42MSN@68525|delta/epsilon subdivisions,2X763@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane protein beta-barrel family - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_353272_2 566466.NOR53_3522 7.74e-14 70.5 COG0457@1|root,COG0457@2|Bacteria,1MYQU@1224|Proteobacteria,1RWMR@1236|Gammaproteobacteria,1JABK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Tetratricopeptide repeat - - - - - - - - - - - - TPR_12,TPR_7 k59_222059_1 1121405.dsmv_0381 7.52e-96 297.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria,2MHX0@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_284932_1 326298.Suden_2034 7.49e-46 153.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,42RFN@68525|delta/epsilon subdivisions,2YP6C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_449823_1 439235.Dalk_2638 1.48e-81 254.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2MIJC@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the thiolase family pcaF - 2.3.1.174,2.3.1.9 ko:K00626,ko:K07823 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R00829,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_284940_1 1121403.AUCV01000005_gene345 9.65e-47 164.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MIU8@213118|Desulfobacterales 28221|Deltaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_284940_2 1125863.JAFN01000001_gene1635 7.98e-55 184.0 COG1099@1|root,COG1099@2|Bacteria,1NDYC@1224|Proteobacteria,42W47@68525|delta/epsilon subdivisions,2WS3B@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TatD related DNase - - - ko:K07051 - - - - ko00000 - - - TatD_DNase k59_90931_1 1121439.dsat_0639 8.6e-90 288.0 COG0243@1|root,COG0243@2|Bacteria,1R5ZE@1224|Proteobacteria,42QK1@68525|delta/epsilon subdivisions,2WPX8@28221|Deltaproteobacteria,2MEF8@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_157560_1 225849.swp_2667 1.2e-41 141.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,2QBXE@267890|Shewanellaceae 1236|Gammaproteobacteria S Uncharacterised protein family UPF0047 yjbQ - - - - - - - - - - - UPF0047 k59_157560_2 1249480.B649_05580 6.74e-43 149.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2YN8Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_318213_1 243233.MCA1233 3.5e-117 340.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1XETJ@135618|Methylococcales 135618|Methylococcales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_776867_1 1121035.AUCH01000006_gene668 6.27e-26 105.0 2AIHJ@1|root,318ZE@2|Bacteria,1Q18Q@1224|Proteobacteria,2W6AT@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_776867_2 765911.Thivi_4550 5.48e-145 424.0 COG0501@1|root,COG4969@1|root,COG0501@2|Bacteria,COG4969@2|Bacteria,1R47C@1224|Proteobacteria,1RPRU@1236|Gammaproteobacteria,1X0GS@135613|Chromatiales 135613|Chromatiales O PFAM Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_776867_4 319224.Sputcn32_3333 7.24e-226 634.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,2Q8Y2@267890|Shewanellaceae 1236|Gammaproteobacteria E TIGRFAM amino acid carrier protein dagA - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_776867_5 1249627.D779_1207 3.39e-211 600.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales 135613|Chromatiales O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_776867_6 426716.JOAJ01000004_gene3222 4.46e-33 136.0 COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4FW9Z@85025|Nocardiaceae 201174|Actinobacteria S Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine egtB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0019439,GO:0019752,GO:0034641,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0055114,GO:0071704,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - DinB_2,FGE-sulfatase k59_776867_7 1122978.AUFP01000001_gene1065 1.15e-26 111.0 COG0545@1|root,COG0545@2|Bacteria,4NP7W@976|Bacteroidetes,2FM5J@200643|Bacteroidia 976|Bacteroidetes M Peptidyl-prolyl cis-trans isomerase fkpB - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_776867_8 396588.Tgr7_0869 5.73e-13 65.1 2ECYK@1|root,336VN@2|Bacteria,1NCGJ@1224|Proteobacteria,1SFQM@1236|Gammaproteobacteria,1WZH5@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_776867_9 1049564.TevJSym_ai00500 1.21e-126 368.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1J4KG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the NadC ModD family nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0109 QRPTase_C,QRPTase_N k59_776867_10 243233.MCA3053 1.18e-94 317.0 COG3170@1|root,COG3170@2|Bacteria,1QV1N@1224|Proteobacteria,1T261@1236|Gammaproteobacteria,1XFD1@135618|Methylococcales 135618|Methylococcales NU Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_776867_11 1122599.AUGR01000012_gene901 3.43e-111 326.0 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,1XIZW@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_776867_12 1049564.TevJSym_ai00540 8.68e-114 334.0 arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_776867_15 1049564.TevJSym_ai00570 1.15e-85 257.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1J61Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG3023 Negative regulator of beta-lactamase expression ampD GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043170,GO:0044424,GO:0044464,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 ko:K01447,ko:K03806 - - R04112 RC00064,RC00141 ko00000,ko01000,ko01011 - - iAF1260.b0110,iB21_1397.B21_00108,iBWG_1329.BWG_0103,iEC55989_1330.EC55989_0103,iECBD_1354.ECBD_3509,iECB_1328.ECB_00109,iECDH10B_1368.ECDH10B_0090,iECDH1ME8569_1439.ECDH1ME8569_0104,iECD_1391.ECD_00109,iECIAI1_1343.ECIAI1_0107,iECO103_1326.ECO103_0110,iECO111_1330.ECO111_0111,iECO26_1355.ECO26_0112,iECSE_1348.ECSE_0110,iECW_1372.ECW_m0107,iEKO11_1354.EKO11_3806,iETEC_1333.ETEC_0106,iEcDH1_1363.EcDH1_3492,iEcE24377_1341.EcE24377A_0112,iEcHS_1320.EcHS_A0114,iEcolC_1368.EcolC_3549,iJO1366.b0110,iSFV_1184.SFV_0101,iSF_1195.SF0107,iSFxv_1172.SFxv_0113,iS_1188.S0109,iUMNK88_1353.UMNK88_108,iWFL_1372.ECW_m0107,iY75_1357.Y75_RS00560 Amidase_2 k59_776867_16 519989.ECTPHS_06117 1.2e-16 85.1 COG3725@1|root,COG3725@2|Bacteria 2|Bacteria - - ampE GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 6.3.1.10 ko:K02227,ko:K03807 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - AmpE,CobD_Cbib k59_776867_18 1049564.TevJSym_ab00410 1.8e-271 761.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1J50Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,STAS_2,Sulfate_transp k59_157561_1 1121918.ARWE01000001_gene2567 2.28e-97 295.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,42NEN@68525|delta/epsilon subdivisions,2WKJP@28221|Deltaproteobacteria,43U1J@69541|Desulfuromonadales 28221|Deltaproteobacteria Q Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_1006183_1 1049564.TevJSym_ad00280 5.23e-89 278.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit - - 1.6.5.3 ko:K05577 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Proton_antipo_M,Proton_antipo_N k59_517505_2 1123326.JFBL01000017_gene2328 3.54e-27 116.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2YNRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU general secretion pathway protein D - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_123659_1 102129.Lepto7375DRAFT_2688 2.82e-54 176.0 COG0454@1|root,COG0456@2|Bacteria,1G9X4@1117|Cyanobacteria,1HG8U@1150|Oscillatoriales 1117|Cyanobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_385255_1 1184609.KILIM_042_00100 2.99e-92 303.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,COG1145@2|Bacteria,2I995@201174|Actinobacteria 201174|Actinobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_647036_1 754476.Q7A_2839 3.83e-93 287.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales 72273|Thiotrichales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_222090_1 553217.ENHAE0001_1650 1.42e-81 260.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,3NIFV@468|Moraxellaceae 1236|Gammaproteobacteria T GTP-binding protein TypA typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1006188_1 563040.Saut_2156 6.95e-118 348.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2YMZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_711767_1 390235.PputW619_1517 3.3e-77 244.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1YWZP@136845|Pseudomonas putida group 1236|Gammaproteobacteria G Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_972957_1 641491.DND132_2118 3.29e-21 90.9 COG0746@1|root,COG0746@2|Bacteria,1RKCH@1224|Proteobacteria,42T8X@68525|delta/epsilon subdivisions,2WP3Q@28221|Deltaproteobacteria,2MB8C@213115|Desulfovibrionales 28221|Deltaproteobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_972957_2 1122947.FR7_2041 4.57e-12 67.0 COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,4H3QS@909932|Negativicutes 909932|Negativicutes H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_253911_1 869213.JCM21142_52179 4.2e-83 257.0 COG0407@1|root,COG0407@2|Bacteria,4NTJT@976|Bacteroidetes 2|Bacteria H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D k59_253911_2 1121957.ATVL01000007_gene1551 1.55e-35 135.0 COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,47KNU@768503|Cytophagia 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_157572_1 469616.FMAG_01103 1.43e-41 152.0 COG1032@1|root,COG1032@2|Bacteria,378ZU@32066|Fusobacteria 32066|Fusobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_157572_2 572544.Ilyop_1335 2.63e-110 335.0 COG2385@1|root,COG2385@2|Bacteria,379FC@32066|Fusobacteria 32066|Fusobacteria D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID k59_157572_3 290402.Cbei_0098 1.1e-27 112.0 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,36EWX@31979|Clostridiaceae 186801|Clostridia D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_647047_1 1165841.SULAR_03607 1.51e-07 51.6 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2YMJU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_647047_2 1165841.SULAR_03183 7.06e-42 152.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,42P0P@68525|delta/epsilon subdivisions,2YN3S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Na H antiporter nhaC - - - - - - - - - - - Na_H_antiporter k59_449861_2 156889.Mmc1_1567 1.8e-59 190.0 COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2TTXE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glyoxalase - - - ko:K08234 - - - - ko00000 - - - Glyoxalase k59_1038109_1 1168034.FH5T_19750 2.32e-13 69.3 COG0527@1|root,COG0527@2|Bacteria,4PKFA@976|Bacteroidetes,2G3F2@200643|Bacteroidia 976|Bacteroidetes E Amino acid kinase family - - 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_1038109_2 1168034.FH5T_19740 3.35e-100 303.0 COG2873@1|root,COG2873@2|Bacteria,4NE27@976|Bacteroidetes,2FMQX@200643|Bacteroidia 976|Bacteroidetes E O-acetylhomoserine aminocarboxypropyltransferase cysteine synthase metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_615051_1 929558.SMGD1_1015 1.29e-87 269.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2YMQ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_190587_2 586416.GZ22_13990 1.66e-05 48.9 COG0438@1|root,COG0438@2|Bacteria,1TPUA@1239|Firmicutes,4HF5B@91061|Bacilli 91061|Bacilli M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_21164_2 563040.Saut_0432 1.6e-24 96.3 COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,42V0C@68525|delta/epsilon subdivisions,2YQBD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Redox-active disulfide protein - - - - - - - - - - - - Thioredoxin_3 k59_647898_1 189425.PGRAT_07185 3.46e-37 140.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4HA13@91061|Bacilli,26QZA@186822|Paenibacillaceae 91061|Bacilli E Catalyzes the transamination of the aromatic amino acid forming a ketoacid yugH - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_549938_1 314278.NB231_13006 7.91e-57 188.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,1WVUP@135613|Chromatiales 135613|Chromatiales M Lipid A biosynthesis acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_875424_1 933262.AXAM01000069_gene2692 4e-82 251.0 COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,42P40@68525|delta/epsilon subdivisions,2WK7K@28221|Deltaproteobacteria,2MHT1@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1009) - - - ko:K09949 - - - - ko00000 - - - DUF1009 k59_222931_1 1366050.N234_34825 2.64e-65 216.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,2VJBZ@28216|Betaproteobacteria,1KB5K@119060|Burkholderiaceae 28216|Betaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_417525_1 402881.Plav_0998 7.43e-46 152.0 COG0848@1|root,COG0848@2|Bacteria,1RHDF@1224|Proteobacteria,2UEA0@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Biopolymer - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_417527_1 1211114.ALIP01000081_gene2507 6.29e-14 72.8 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X3EN@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the peptidase S1C family htrA - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_417527_2 1158165.KB898871_gene2501 2.04e-11 61.2 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1WYTK@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_286083_1 509191.AEDB02000017_gene100 2.59e-38 137.0 COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,3WGD3@541000|Ruminococcaceae 186801|Clostridia P ABC 3 transport family protein - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_450922_1 929558.SMGD1_1696 3.88e-48 174.0 COG4783@1|root,COG4783@2|Bacteria,1QZ2M@1224|Proteobacteria,43CEP@68525|delta/epsilon subdivisions,2YTC5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S chaperone-mediated protein folding - - - - - - - - - - - - - k59_386325_1 272630.MexAM1_META1p3129 6.67e-12 70.9 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2TRPJ@28211|Alphaproteobacteria,1JZFY@119045|Methylobacteriaceae 28211|Alphaproteobacteria M TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_615084_1 1168034.FH5T_14805 2.08e-37 127.0 COG0640@1|root,COG0640@2|Bacteria,4NQK3@976|Bacteroidetes,2FT4U@200643|Bacteroidia 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - HTH_20,HTH_5 k59_941895_1 572544.Ilyop_1476 2.03e-169 478.0 COG1159@1|root,COG1159@2|Bacteria,378FD@32066|Fusobacteria 32066|Fusobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_941895_2 572544.Ilyop_1477 2e-71 228.0 COG4974@1|root,COG4974@2|Bacteria,379Q6@32066|Fusobacteria 32066|Fusobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_941895_3 1278306.KB906912_gene869 1.8e-55 189.0 COG0497@1|root,COG0497@2|Bacteria,378SP@32066|Fusobacteria 32066|Fusobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_124662_1 471874.PROSTU_04578 1.59e-68 215.0 COG3022@1|root,COG3022@2|Bacteria,1MUAF@1224|Proteobacteria,1RMTD@1236|Gammaproteobacteria,3Z7VA@586|Providencia 1236|Gammaproteobacteria S Belongs to the UPF0246 family yaaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700 - ko:K09861 - - - - ko00000 - - - H2O2_YaaD k59_354034_2 1165841.SULAR_04027 7.77e-55 175.0 COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,42TYT@68525|delta/epsilon subdivisions,2YRZQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L May nick specific sequences that contain T G mispairs resulting from m5C-deamination - - - ko:K07458 - - - - ko00000,ko01000,ko03400 - - - DUF559,Vsr k59_354034_3 1137281.D778_01383 1.68e-114 343.0 28HT5@1|root,2Z803@2|Bacteria,4NQQY@976|Bacteroidetes,1I3R2@117743|Flavobacteriia 976|Bacteroidetes L HpaII restriction endonuclease hpaIIR - 3.1.21.4 ko:K01155 - - - - ko00000,ko01000,ko02048 - - - RE_HpaII k59_354034_4 746697.Aeqsu_0738 5.94e-138 405.0 COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,1HZAK@117743|Flavobacteriia 976|Bacteroidetes H cytosine-specific methyltransferase hpaIIM - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_450937_1 2340.JV46_26700 1.94e-61 201.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain dgcB - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_124663_1 1168034.FH5T_17440 4.78e-99 304.0 COG2027@1|root,COG2027@2|Bacteria,4NGIQ@976|Bacteroidetes,2FM0Y@200643|Bacteroidia 976|Bacteroidetes M COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_1039230_1 1390370.O203_11730 8.23e-58 200.0 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,1YDD5@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF k59_417548_1 1168034.FH5T_07285 2.03e-99 297.0 28IG3@1|root,2Z8HM@2|Bacteria,4NFJR@976|Bacteroidetes,2FTZD@200643|Bacteroidia 976|Bacteroidetes S Gliding motility-associated protein, GldL gldL - - - - - - - - - - - - k59_417548_2 1168034.FH5T_07270 3.96e-21 91.7 COG1262@1|root,COG1262@2|Bacteria,4NGY2@976|Bacteroidetes,2FPTN@200643|Bacteroidia 976|Bacteroidetes M gliding motility-associated lipoprotein GldK gldK - - - - - - - - - - - FGE-sulfatase k59_712544_1 519989.ECTPHS_01674 1.34e-26 99.8 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1WYWY@135613|Chromatiales 135613|Chromatiales J Sigma 54 modulation protein - - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_712544_2 631362.Thi970DRAFT_02465 1.3e-47 165.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1WVZD@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_910828_1 1144305.PMI02_02713 5.43e-15 81.6 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2K0P4@204457|Sphingomonadales 204457|Sphingomonadales M PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_389435_1 745411.B3C1_04635 7.67e-38 144.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1J98P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Domain of unknown function (DUF1974) fadE GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0217 Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_193390_1 1537917.JU82_00235 1.95e-95 288.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2YMQ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_193390_2 929558.SMGD1_1226 1.18e-50 187.0 COG2319@1|root,COG2319@2|Bacteria,1Q4KY@1224|Proteobacteria,42ZEF@68525|delta/epsilon subdivisions,2YR4A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S WD40 repeats - - - - - - - - - - - - - k59_454035_2 76114.p2A174 4.08e-99 308.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria,2KY8S@206389|Rhodocyclales 28216|Betaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_584892_1 765912.Thimo_1075 1.81e-23 100.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,1RP8V@1236|Gammaproteobacteria,1WXFT@135613|Chromatiales 135613|Chromatiales M D-Ala-D-Ala carboxypeptidase - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_877711_2 387093.SUN_0073 2.06e-63 206.0 COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,42P5E@68525|delta/epsilon subdivisions,2YN01@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Fad-dependent pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_520747_1 1304883.KI912532_gene2473 7.42e-32 121.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,2KUW2@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_520747_2 863365.XHC_1117 3.83e-36 125.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,1X7EF@135614|Xanthomonadales 135614|Xanthomonadales IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_93855_1 1123368.AUIS01000001_gene1868 6.56e-128 372.0 COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,1S11K@1236|Gammaproteobacteria,2NBQA@225057|Acidithiobacillales 225057|Acidithiobacillales E DAHP synthetase I family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_714947_1 1005395.CSV86_05027 2.62e-28 118.0 COG4928@1|root,COG4928@2|Bacteria,1MWRP@1224|Proteobacteria,1RZUM@1236|Gammaproteobacteria,1YZ2C@136845|Pseudomonas putida group 1236|Gammaproteobacteria S KAP family P-loop domain - - - - - - - - - - - - KAP_NTPase k59_485015_1 1209072.ALBT01000035_gene1492 7.44e-86 263.0 COG4733@1|root,COG5297@1|root,COG4733@2|Bacteria,COG5297@2|Bacteria,1R6PF@1224|Proteobacteria,1RZMP@1236|Gammaproteobacteria,1FHZK@10|Cellvibrio 1236|Gammaproteobacteria G Pectate lyase hrpW - - - - - - - - - - - Pectate_lyase k59_617956_1 237368.SCABRO_03925 1.24e-12 64.3 2B1XW@1|root,31UE7@2|Bacteria 2|Bacteria S S23 ribosomal protein - - - - - - - - - - - - 23S_rRNA_IVP k59_617956_2 1168034.FH5T_03070 1.2e-70 228.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,4PKV4@976|Bacteroidetes,2FNTR@200643|Bacteroidia 976|Bacteroidetes C COG4624 Iron only hydrogenase large subunit C-terminal domain hndD - 1.12.1.3,1.17.1.9 ko:K00123,ko:K18332 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_288629_1 347834.RHE_CH01060 5.68e-06 47.0 COG3703@1|root,COG3703@2|Bacteria 2|Bacteria P gamma-glutamylcyclotransferase activity - - - ko:K07232 - - - - ko00000 - - - ChaC k59_288629_2 1123487.KB892868_gene1286 6.84e-10 63.2 COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria 28216|Betaproteobacteria EGP major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_584905_1 1537994.JQFW01000004_gene3198 1.17e-27 108.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,466CG@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) ycdF - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 k59_584905_2 391625.PPSIR1_40485 1.08e-16 81.3 COG0793@1|root,COG0793@2|Bacteria,1MUA3@1224|Proteobacteria,43413@68525|delta/epsilon subdivisions,2X4K3@28221|Deltaproteobacteria,2YZ68@29|Myxococcales 28221|Deltaproteobacteria M Peptidase family S41 - - - - - - - - - - - - PDZ_2,Peptidase_S41 k59_976170_1 935866.JAER01000003_gene1177 5.03e-134 404.0 COG0515@1|root,COG0515@2|Bacteria,2GJ24@201174|Actinobacteria,4DPBP@85009|Propionibacteriales 201174|Actinobacteria KLT Protein kinase G tetratricopeptide repeat pknG - 2.7.11.1 ko:K14949 ko05152,map05152 - - - ko00000,ko00001,ko01000,ko01001 - - - Pkinase,PknG_TPR,PknG_rubred k59_809235_1 637905.SVI_2713 6.5e-116 353.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,2QEU3@267890|Shewanellaceae 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_288630_1 1278306.KB906908_gene577 3.98e-11 62.0 COG1211@1|root,COG1211@2|Bacteria,379Y6@32066|Fusobacteria 32066|Fusobacteria I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_288630_2 572544.Ilyop_1845 2.6e-45 164.0 COG1193@1|root,COG1193@2|Bacteria,378XS@32066|Fusobacteria 32066|Fusobacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_780561_1 583355.Caka_2618 1.72e-44 155.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_126752_2 589924.Ferp_2487 1.05e-51 174.0 COG0123@1|root,arCOG00324@2157|Archaea,2Y2ST@28890|Euryarchaeota,246Y4@183980|Archaeoglobi 183980|Archaeoglobi BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_356560_1 498761.HM1_2934 2.56e-170 483.0 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,247TB@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - DUF2800 k59_485033_2 936155.HFELIS_04690 2.43e-42 151.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,42MX8@68525|delta/epsilon subdivisions,2YN00@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flaB GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_23656_1 504472.Slin_3066 8.32e-39 142.0 COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,47KKB@768503|Cytophagia 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_617976_1 869213.JCM21142_41874 7.24e-83 253.0 COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,47JMW@768503|Cytophagia 976|Bacteroidetes I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_389483_1 314278.NB231_01274 5.27e-88 285.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_1041655_1 96561.Dole_1718 7.03e-65 211.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2WIPM@28221|Deltaproteobacteria,2MITD@213118|Desulfobacterales 28221|Deltaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_845786_1 765910.MARPU_01935 3.11e-87 271.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_1009919_2 1168034.FH5T_09275 9.92e-61 191.0 COG2391@1|root,COG2391@2|Bacteria,4NMK0@976|Bacteroidetes 976|Bacteroidetes S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_845802_1 159087.Daro_2248 4.59e-30 112.0 COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,2KW4E@206389|Rhodocyclales 206389|Rhodocyclales S membrane - - - - - - - - - - - - UPF0016 k59_845802_2 399795.CtesDRAFT_PD1714 5.58e-20 87.8 COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2VGZA@28216|Betaproteobacteria,4AI6A@80864|Comamonadaceae 28216|Betaproteobacteria C Has an organic peroxide-dependent peroxidase activity - - 1.11.1.6 ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 M00532 R00009,R00602,R02670 RC00034,RC00767,RC02141,RC02755 ko00000,ko00001,ko00002,ko01000 - - - Catalase k59_60280_1 948106.AWZT01000017_gene31 1.28e-66 227.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria,1JZQJ@119060|Burkholderiaceae 28216|Betaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_357147_1 384676.PSEEN3782 3.69e-13 70.1 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria 1236|Gammaproteobacteria O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479 ABC_tran k59_976993_2 1355374.JARU01000004_gene1440 1.77e-15 74.3 COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,42TJ0@68525|delta/epsilon subdivisions,2YPZ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T phosphohistidine phosphatase, SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_257854_1 1298880.AUEV01000013_gene3895 1.33e-21 98.6 COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria 201174|Actinobacteria S tail sheath protein - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_127444_1 1333998.M2A_2095 9.74e-74 243.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,4BRK5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_746665_1 880073.Calab_3467 2.11e-39 152.0 COG0708@1|root,COG4886@1|root,COG0708@2|Bacteria,COG4886@2|Bacteria 2|Bacteria S regulation of response to stimulus - - 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH13 - DUF3160,Flg_new,LRR_5 k59_810051_1 1406840.Q763_15780 5.29e-142 412.0 COG0621@1|root,COG0621@2|Bacteria,4NDU6@976|Bacteroidetes,1HX6T@117743|Flavobacteriia,2NSNS@237|Flavobacterium 976|Bacteroidetes J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_977006_2 90814.KL370891_gene813 2.16e-62 205.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1RMFI@1236|Gammaproteobacteria,460B3@72273|Thiotrichales 72273|Thiotrichales C PFAM NADH flavin oxidoreductase NADH oxidase family - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_289151_1 1246459.KB898353_gene347 1.37e-52 194.0 COG1345@1|root,COG2931@1|root,COG2982@1|root,COG3209@1|root,COG3210@1|root,COG5295@1|root,COG1345@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4BB16@82115|Rhizobiaceae 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4214,DUF4347,HCBP_related,He_PIG,HemolysinCabind,Metallophos,P_proprotein,Peptidase_S8 k59_161900_1 1429851.X548_06505 2.68e-57 189.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1X4F8@135614|Xanthomonadales 135614|Xanthomonadales L glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_161900_2 1178482.BJB45_01035 3.02e-16 78.2 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XIAH@135619|Oceanospirillales 135619|Oceanospirillales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_94447_2 1283300.ATXB01000001_gene2322 2.79e-39 145.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1XDTU@135618|Methylococcales 135618|Methylococcales H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_715584_1 313596.RB2501_09515 3.28e-41 143.0 COG0698@1|root,COG0698@2|Bacteria,4NP5D@976|Bacteroidetes,1I2XE@117743|Flavobacteriia 976|Bacteroidetes G Ribose/Galactose Isomerase - - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_945033_1 763034.HMPREF9446_03223 1.3e-62 203.0 COG0275@1|root,COG0275@2|Bacteria,4NFQB@976|Bacteroidetes,2FMPT@200643|Bacteroidia,4AM5W@815|Bacteroidaceae 976|Bacteroidetes J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_357159_1 349124.Hhal_1870 1.61e-105 315.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C6@1236|Gammaproteobacteria,1WXH4@135613|Chromatiales 135613|Chromatiales C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_357161_1 234267.Acid_0868 5.43e-08 53.5 COG3665@1|root,COG3665@2|Bacteria,3Y61C@57723|Acidobacteria 57723|Acidobacteria S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_357161_2 1121403.AUCV01000031_gene2816 1.31e-62 197.0 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,42QUI@68525|delta/epsilon subdivisions,2WSPS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF1989) - - - - - - - - - - - - DUF1989 k59_553586_1 1168034.FH5T_13680 6.51e-98 294.0 COG3088@1|root,COG3088@2|Bacteria,4NGHU@976|Bacteroidetes,2FP8Y@200643|Bacteroidia 976|Bacteroidetes O Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - k59_127469_1 1168034.FH5T_09215 1.12e-05 47.4 COG2220@1|root,COG2220@2|Bacteria,4NFJ4@976|Bacteroidetes,2FNMD@200643|Bacteroidia 976|Bacteroidetes S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_127469_2 1077285.AGDG01000004_gene2298 3.25e-27 115.0 COG4948@1|root,COG4948@2|Bacteria,4PKP3@976|Bacteroidetes,2FMI4@200643|Bacteroidia,4AMKV@815|Bacteroidaceae 976|Bacteroidetes M COG NOG06228 non supervised orthologous group - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - GH97_C,GH97_N,Glyco_hydro_97 k59_161908_1 1123377.AUIV01000002_gene1156 7.44e-39 145.0 COG1028@1|root,COG3320@1|root,COG1028@2|Bacteria,COG3320@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1X3FH@135614|Xanthomonadales 135614|Xanthomonadales Q Male sterility protein - - - - - - - - - - - - NAD_binding_4,adh_short k59_161908_2 1479237.JMLY01000001_gene3618 7.02e-74 244.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1S1HS@1236|Gammaproteobacteria,46DMD@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Condensation domain - - - - - - - - - - - - DUF1298,WES_acyltransf k59_977033_1 709032.Sulku_0531 5.48e-88 265.0 COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,42PCG@68525|delta/epsilon subdivisions,2YN6X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S metallophosphoesterase - - - ko:K09769 - - - - ko00000 - - - YmdB k59_977033_2 563040.Saut_0592 4.6e-16 77.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2YMGZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_945045_1 1165841.SULAR_06123 1.15e-131 390.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2YMRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_650624_1 1313304.CALK_1813 1.85e-31 117.0 COG1051@1|root,COG1051@2|Bacteria 2|Bacteria F GDP-mannose mannosyl hydrolase activity mutT - 3.6.1.13,3.6.1.55,3.6.1.56,3.6.1.62,3.6.1.64 ko:K01515,ko:K03574,ko:K16855,ko:K17816 ko00230,ko03018,map00230,map03018 - R00961,R01054,R10235,R10815 RC00002 ko00000,ko00001,ko01000,ko03019,ko03400 - - - NUDIX k59_781227_1 1173028.ANKO01000009_gene1721 1.59e-56 180.0 COG1848@1|root,COG1848@2|Bacteria,1G80N@1117|Cyanobacteria,1HDV1@1150|Oscillatoriales 1117|Cyanobacteria S PIN domain - - - - - - - - - - - - PIN k59_454871_1 314278.NB231_16118 7.3e-07 50.8 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1WXFV@135613|Chromatiales 135613|Chromatiales J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_454871_2 686340.Metal_1078 4.39e-53 175.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1XF2E@135618|Methylococcales 135618|Methylococcales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_257889_1 713586.KB900536_gene2944 5.67e-50 166.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1WYWG@135613|Chromatiales 135613|Chromatiales H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_289181_1 1207075.PputUW4_03091 3.17e-26 103.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria 1236|Gammaproteobacteria H polyphosphate kinase ppk2 - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_553606_1 926566.Terro_2761 1.48e-54 179.0 COG1137@1|root,COG1137@2|Bacteria,3Y2MC@57723|Acidobacteria,2JHPV@204432|Acidobacteriia 204432|Acidobacteriia S ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_485674_1 1168034.FH5T_15040 9.18e-46 156.0 COG0473@1|root,COG0473@2|Bacteria,4NEBE@976|Bacteroidetes,2FNJ0@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_485674_2 1168034.FH5T_15045 6.55e-77 244.0 COG0119@1|root,COG0119@2|Bacteria,4NF3N@976|Bacteroidetes,2FKYJ@200643|Bacteroidia 976|Bacteroidetes E Belongs to the alpha-IPM synthase homocitrate synthase family leuA_1 - 2.3.1.182 ko:K09011 ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230 M00535 R07399 RC00004,RC01205 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_683958_1 1366050.N234_31455 4.77e-20 86.3 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2VH10@28216|Betaproteobacteria,1K0A7@119060|Burkholderiaceae 28216|Betaproteobacteria H GTP cyclohydrolase folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_683958_2 1538295.JY96_05340 4.28e-58 184.0 COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,2VQFF@28216|Betaproteobacteria,1KKUR@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Sensors of blue-light using FAD - - - - - - - - - - - - BLUF k59_945056_1 96561.Dole_0849 5.83e-70 234.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MIPG@213118|Desulfobacterales 28221|Deltaproteobacteria G phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_845876_1 323261.Noc_2822 3.49e-05 45.4 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales 135613|Chromatiales F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_845876_2 1382359.JIAL01000001_gene2207 2.43e-47 157.0 COG2905@1|root,COG2905@2|Bacteria,3Y5NG@57723|Acidobacteria,2JN0N@204432|Acidobacteriia 204432|Acidobacteriia T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_810120_1 926561.KB900617_gene1320 4.85e-63 215.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3WBD0@53433|Halanaerobiales 186801|Clostridia E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_810120_2 1116231.SMA_1886 1.64e-14 74.7 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,4HA4G@91061|Bacilli 91061|Bacilli E glutamate synthase gltA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_810120_3 267747.PPA1135 4.73e-20 89.4 COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4DNI1@85009|Propionibacteriales 201174|Actinobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster gltD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iNJ661.Rv3858c Fer4_20,Pyr_redox_2 k59_945059_1 1168034.FH5T_00630 1.18e-164 476.0 COG1069@1|root,COG1069@2|Bacteria,4NEFQ@976|Bacteroidetes,2FNNI@200643|Bacteroidia 976|Bacteroidetes G Belongs to the ribulokinase family araB - 2.7.1.16 ko:K00853 ko00040,ko01100,map00040,map01100 - R01526,R02439 RC00002,RC00538 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_746711_1 758.BBIX01000008_gene1255 5.46e-87 275.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1Y7P6@135625|Pasteurellales 135625|Pasteurellales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_878449_1 357276.EL88_02595 1.37e-16 86.7 COG0249@1|root,COG4227@1|root,COG0249@2|Bacteria,COG4227@2|Bacteria,4NM80@976|Bacteroidetes,2FNM1@200643|Bacteroidia,4AWCE@815|Bacteroidaceae 976|Bacteroidetes L DNA primase TraC - - - - - - - - - - - - DUF1738 k59_161946_1 1397527.Q670_05425 9.56e-09 61.2 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XIW5@135619|Oceanospirillales 135619|Oceanospirillales NU Tfp pilus assembly protein - - - ko:K08086 - - - - ko00000 - - - LysM,TPR_19 k59_127491_1 1550073.JROH01000025_gene1016 3.37e-124 377.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2K0PZ@204457|Sphingomonadales 204457|Sphingomonadales E gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_127491_2 1238182.C882_3713 2.03e-48 173.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2JQAX@204441|Rhodospirillales 204441|Rhodospirillales V ABC-type multidrug transport system, ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_97624_22 283942.IL0308 9.84e-68 209.0 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,1S6S0@1236|Gammaproteobacteria,2QGUA@267893|Idiomarinaceae 1236|Gammaproteobacteria J Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ybaK GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_97624_23 265072.Mfla_1158 2.16e-144 421.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VHQF@28216|Betaproteobacteria 28216|Betaproteobacteria O S6, chymotrypsin Hap - - 1.3.1.74 ko:K08070 - - - - ko00000,ko01000 - - - PDZ_2,Trypsin_2 k59_97624_24 1453501.JELR01000001_gene2874 1.77e-120 358.0 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,46BQ5@72275|Alteromonadaceae 1236|Gammaproteobacteria U Cation efflux family catA - - - - - - - - - - - Cation_efflux,ZT_dimer k59_97624_25 1049564.TevJSym_bi00100 3.79e-217 611.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1J56U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the acetyltransferase family. ArgA subfamily argA GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226 AA_kinase,Acetyltransf_1 k59_97624_26 396588.Tgr7_0573 4.02e-173 494.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M20A family. ArgE subfamily - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_294041_1 1121022.ABENE_13040 6.07e-34 132.0 COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,2U2Q3@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_5 k59_29018_1 754476.Q7A_1033 3.89e-114 346.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,4607X@72273|Thiotrichales 72273|Thiotrichales JKL DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_294054_1 319225.Plut_1805 4.35e-46 156.0 COG1848@1|root,COG1848@2|Bacteria 2|Bacteria G Toxic component of a toxin-antitoxin (TA) module. An RNase - - 2.6.1.98 ko:K13017 ko00520,map00520 - R10141 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - PIN,PIN_3 k59_294054_2 1121406.JAEX01000043_gene716 1.24e-28 107.0 COG2856@1|root,COG2856@2|Bacteria 2|Bacteria E Zn peptidase - - - - - - - - - - - - Peptidase_M78 k59_64889_2 760142.Hipma_0058 4.27e-84 255.0 COG0529@1|root,COG0529@2|Bacteria,1PJGN@1224|Proteobacteria,43A5M@68525|delta/epsilon subdivisions,2X26H@28221|Deltaproteobacteria,2M7K5@213113|Desulfurellales 28221|Deltaproteobacteria P Adenylylsulphate kinase - - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_64889_3 944547.ABLL_2806 5.34e-51 169.0 COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,42NYE@68525|delta/epsilon subdivisions,2YN2H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase cysD - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_326889_1 1366050.N234_08530 1.51e-68 232.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1K0BE@119060|Burkholderiaceae 28216|Betaproteobacteria CK PFAM GCN5-related N-acetyltransferase - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_64911_1 1168034.FH5T_12745 3.99e-51 174.0 COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,2FREU@200643|Bacteroidia 976|Bacteroidetes H Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_64911_2 1168034.FH5T_12740 2.51e-158 450.0 COG0407@1|root,COG0407@2|Bacteria,4NEQ7@976|Bacteroidetes,2FPSK@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_64913_2 999419.HMPREF1077_01941 5.92e-09 57.0 COG0340@1|root,COG0340@2|Bacteria,4NHCH@976|Bacteroidetes,2FMM7@200643|Bacteroidia,22XZH@171551|Porphyromonadaceae 976|Bacteroidetes H Biotin/lipoate A/B protein ligase family birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_LplA_LipB k59_29078_1 869213.JCM21142_41955 5.54e-15 79.3 COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,47MCG@768503|Cytophagia 976|Bacteroidetes IQ AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897,ko:K18660 ko00061,ko00071,ko00280,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00280,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280,R03383 RC00004,RC00014,RC00137 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,PP-binding k59_294164_1 1122134.KB893650_gene1380 6.01e-16 82.4 COG5563@1|root,COG5563@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Autotransporter,CBM_4_9,DUF3466,FG-GAP_2 k59_64970_1 4572.TRIUR3_00079-P1 0.0 989.0 COG0086@1|root,2QPYA@2759|Eukaryota,37HSD@33090|Viridiplantae,3GDVE@35493|Streptophyta,3KV60@4447|Liliopsida,3I5C8@38820|Poales 35493|Streptophyta K DNA-directed RNA polymerase rpoC2 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_815528_2 709032.Sulku_0224 1.25e-66 214.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2YMF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran k59_64989_1 1042377.AFPJ01000054_gene1715 1.61e-81 260.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,4674P@72275|Alteromonadaceae 1236|Gammaproteobacteria EU Prolyl oligopeptidase, N-terminal beta-propeller domain - - - - - - - - - - - - PD40,Peptidase_S9,Peptidase_S9_N k59_29155_1 1249480.B649_00335 8.95e-183 529.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42Q5F@68525|delta/epsilon subdivisions,2YPMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Cache_3-Cache_2,MCPsignal k59_65061_1 765912.Thimo_1577 5.49e-98 291.0 COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria,1WXG2@135613|Chromatiales 135613|Chromatiales V (ABC) transporter - - - - - - - - - - - - - k59_29225_1 861299.J421_1491 5.05e-53 181.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1ZSZ7@142182|Gemmatimonadetes 142182|Gemmatimonadetes CE Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3 k59_65163_1 316055.RPE_3768 1.63e-26 104.0 COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,3JQRA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Cytochrome c cyc - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_65163_2 1205680.CAKO01000004_gene3605 4.61e-54 177.0 COG1028@1|root,COG1028@2|Bacteria,1R4GD@1224|Proteobacteria,2TVNF@28211|Alphaproteobacteria,2JWE1@204441|Rhodospirillales 204441|Rhodospirillales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_65197_1 713586.KB900536_gene1289 7.76e-28 116.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,1WYW3@135613|Chromatiales 135613|Chromatiales O Tetratricopeptide repeats - - - - - - - - - - - - TPR_16,TPR_8,Trans_reg_C k59_29337_1 1185876.BN8_05143 8.34e-31 120.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,47K8Q@768503|Cytophagia 976|Bacteroidetes E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_815736_1 765913.ThidrDRAFT_3545 8.99e-20 89.7 COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,1SCGA@1236|Gammaproteobacteria,1WXZ4@135613|Chromatiales 135613|Chromatiales H Belongs to the P-Pant transferase superfamily - - - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_815736_2 85643.Tmz1t_1700 4.39e-08 55.1 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria,2KVUG@206389|Rhodocyclales 206389|Rhodocyclales NU NYN domain - - - - - - - - - - - - NYN k59_29353_1 1348635.BBJY01000013_gene1020 3.27e-112 352.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1XSMS@135623|Vibrionales 135623|Vibrionales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_29410_1 1502852.FG94_01095 1.32e-115 348.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,472ND@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_815815_1 990073.ATHU01000001_gene1252 6.76e-09 53.5 COG2768@1|root,COG2768@2|Bacteria,1QZF1@1224|Proteobacteria,43CIA@68525|delta/epsilon subdivisions,2YTCX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7 k59_29472_1 1168034.FH5T_16745 3.03e-86 261.0 COG1234@1|root,COG1234@2|Bacteria,4NE1K@976|Bacteroidetes,2FM13@200643|Bacteroidia 976|Bacteroidetes S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_29472_2 1168034.FH5T_16750 1.53e-23 91.7 COG1366@1|root,COG1366@2|Bacteria,4NTAB@976|Bacteroidetes,2FYPE@200643|Bacteroidia 976|Bacteroidetes T STAS domain - - - - - - - - - - - - STAS,STAS_2 k59_65359_1 1313421.JHBV01000022_gene4690 3.04e-52 178.0 COG5505@1|root,COG5505@2|Bacteria,4NE2H@976|Bacteroidetes,1IPAU@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF819) - - - - - - - - - - - - DUF819 k59_816005_1 1123034.JMKP01000027_gene2148 7.45e-45 160.0 COG2304@1|root,COG2304@2|Bacteria,1QDZ4@1224|Proteobacteria,1RZ30@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oxidoreductase activity - - - - - - - - - - - - - k59_29602_1 1453496.AT03_06710 5.84e-14 69.7 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria 1236|Gammaproteobacteria K belongs to the Fur family fur GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_29602_2 387093.SUN_0482 3.02e-21 94.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2YMR5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_29603_1 1537917.JU82_06585 4.94e-98 289.0 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2YNQD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Histidine biosynthesis bifunctional protein hisIE hisI - 3.5.4.19,3.6.1.31 ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_816042_1 999541.bgla_2g19330 3e-78 262.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1K1YU@119060|Burkholderiaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_816059_1 1168034.FH5T_06775 1.13e-95 283.0 COG1917@1|root,COG1917@2|Bacteria,4NMER@976|Bacteroidetes,2G0DI@200643|Bacteroidia 976|Bacteroidetes K Cupin domain - - - - - - - - - - - - Cupin_2,HTH_19,HTH_3 k59_816059_2 1168034.FH5T_06770 2.61e-20 89.0 COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,2FMTR@200643|Bacteroidia 976|Bacteroidetes IQ Psort location Cytoplasmic, score 9.97 - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_29652_1 439235.Dalk_4515 2.73e-64 215.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_816122_1 713586.KB900536_gene1501 2.59e-38 144.0 COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,1S09M@1236|Gammaproteobacteria,1X09N@135613|Chromatiales 135613|Chromatiales OQ Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_816144_1 523791.Kkor_1690 5.06e-100 292.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1XI80@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_29749_1 1537917.JU82_04610 2.4e-71 223.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2YNN2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_29749_2 1537917.JU82_04605 6.67e-44 149.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2YMZQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_816176_1 1397528.Q671_10585 1.14e-80 256.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,1XIK6@135619|Oceanospirillales 135619|Oceanospirillales L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_29777_1 929558.SMGD1_0377 2.48e-12 65.1 COG0835@1|root,COG0835@2|Bacteria 2|Bacteria NT chemotaxis - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW,Response_reg k59_29777_2 929558.SMGD1_0378 3.52e-151 454.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2YMB9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T chemotaxis protein cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_29815_1 1384056.N787_11595 1.66e-92 286.0 COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,1X56I@135614|Xanthomonadales 135614|Xanthomonadales C Na+/H+ antiporter family - - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k59_816328_1 96561.Dole_1475 2.88e-88 267.0 COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,43BR5@68525|delta/epsilon subdivisions,2X725@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_29933_1 1168034.FH5T_04765 3.68e-54 176.0 COG0253@1|root,COG0253@2|Bacteria,4NF26@976|Bacteroidetes,2FNI4@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_29992_1 313606.M23134_03584 2.11e-12 70.1 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,47K49@768503|Cytophagia 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_816438_1 1454004.AW11_03086 4.99e-96 302.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria 28216|Betaproteobacteria P Pfam Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_816522_1 323848.Nmul_A2709 2.27e-23 95.9 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,371NN@32003|Nitrosomonadales 28216|Betaproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_30179_1 983917.RGE_38090 7.02e-138 404.0 COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2VJB1@28216|Betaproteobacteria,1KMXV@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_30215_1 1294143.H681_17250 1.47e-11 70.5 COG2199@1|root,COG3706@2|Bacteria,1RDWG@1224|Proteobacteria,1S7W2@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_816670_1 1249480.B649_09620 1.19e-71 227.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2YMAS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Small subunit hydA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.5.1 ko:K05927 - - - - ko00000,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_30238_1 521000.PROVRETT_07506 1.75e-35 142.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,3Z7YC@586|Providencia 1236|Gammaproteobacteria P Psort location CytoplasmicMembrane, score 10.00 copA GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035434,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060003,GO:0061687,GO:0070887,GO:0071241,GO:0071248,GO:0071280,GO:0071292,GO:0071944,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:1902601,GO:1990169 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - iEC55989_1330.EC55989_0497,iECIAI1_1343.ECIAI1_0487,iECO103_1326.ECO103_0460,iECSE_1348.ECSE_0509,iECW_1372.ECW_m0557,iEKO11_1354.EKO11_3363,iWFL_1372.ECW_m0557 E1-E2_ATPase,HMA,Hydrolase k59_816741_1 566466.NOR53_3348 1.71e-14 78.2 COG1570@1|root,COG3170@1|root,COG1570@2|Bacteria,COG3170@2|Bacteria,1N7EX@1224|Proteobacteria,1SMK5@1236|Gammaproteobacteria,1J8F7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_30317_1 666685.R2APBS1_2749 9.74e-09 56.2 COG2963@1|root,COG2963@2|Bacteria,1N1CG@1224|Proteobacteria,1SAIC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_816824_3 1537917.JU82_08405 6.6e-73 228.0 COG3751@1|root,COG3751@2|Bacteria,1Q4MK@1224|Proteobacteria,42ZFP@68525|delta/epsilon subdivisions,2YRNS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Prolyl 4-hydroxylase alpha subunit homologues. - - - ko:K07394 - - - - ko00000 - - - 2OG-FeII_Oxy_3 k59_30402_1 1168034.FH5T_15240 1.74e-43 157.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE4A@976|Bacteroidetes,2FX71@200643|Bacteroidia 976|Bacteroidetes C Dehydrogenase E1 component pdhB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_816876_1 748247.AZKH_p0367 4.54e-41 150.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VH5N@28216|Betaproteobacteria 28216|Betaproteobacteria Q ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_262298_2 1042376.AFPK01000036_gene1929 2.97e-79 250.0 COG1619@1|root,COG1619@2|Bacteria,4NF5Q@976|Bacteroidetes,1HXC6@117743|Flavobacteriia,406AZ@61432|unclassified Flavobacteriaceae 976|Bacteroidetes V LD-carboxypeptidase ykfA - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_262298_3 338966.Ppro_3203 1.21e-07 53.9 COG0546@1|root,COG0546@2|Bacteria,1REXF@1224|Proteobacteria,43B2S@68525|delta/epsilon subdivisions,2WN4A@28221|Deltaproteobacteria 28221|Deltaproteobacteria S HAD-hyrolase-like - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1014175_2 927658.AJUM01000034_gene485 1.72e-05 49.3 COG3637@1|root,COG3637@2|Bacteria,4NNFR@976|Bacteroidetes,2FV0V@200643|Bacteroidia,3XK3Z@558415|Marinilabiliaceae 976|Bacteroidetes M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_393161_1 1392488.JHZY01000004_gene1982 4.44e-39 150.0 COG4206@1|root,COG4206@2|Bacteria,4NHTX@976|Bacteroidetes,1I7EP@117743|Flavobacteriia,2XJUR@283735|Leeuwenhoekiella 976|Bacteroidetes H TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_850759_1 1304880.JAGB01000002_gene2196 1.65e-144 421.0 COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia 186801|Clostridia M Monogalactosyldiacylglycerol synthase - - 2.4.1.315 ko:K03429 ko00561,ko01100,map00561,map01100 - R02689,R04377 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT28 - Glyco_tran_28_C,Glycos_transf_1,MGDG_synth k59_850759_2 1238184.CM001792_gene3496 3.25e-99 300.0 COG0329@1|root,COG0329@2|Bacteria,1TPVS@1239|Firmicutes,4HATJ@91061|Bacilli,23NCD@182709|Oceanobacillus 91061|Bacilli EM Dihydrodipicolinate synthetase family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_33556_1 335543.Sfum_0271 3.02e-39 142.0 COG0659@1|root,COG0659@2|Bacteria,1MX1U@1224|Proteobacteria,42QCR@68525|delta/epsilon subdivisions,2WIP7@28221|Deltaproteobacteria,2MQDZ@213462|Syntrophobacterales 28221|Deltaproteobacteria P Molybdate transporter of MFS superfamily - - - - - - - - - - - - MFS_MOT1 k59_33556_2 768671.ThimaDRAFT_3603 1.95e-10 59.3 COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,1RQ3M@1236|Gammaproteobacteria,1X266@135613|Chromatiales 135613|Chromatiales P Cation efflux family - - - - - - - - - - - - Cation_efflux k59_720004_1 1537917.JU82_02705 9.93e-93 286.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2YMQ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_262301_1 1172190.M947_04010 1.08e-99 303.0 COG0591@1|root,COG0591@2|Bacteria,1MYTC@1224|Proteobacteria,42P8Z@68525|delta/epsilon subdivisions,2YN9K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_133424_1 1121405.dsmv_3387 8.93e-12 63.2 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2WPHH@28221|Deltaproteobacteria,2MJYY@213118|Desulfobacterales 28221|Deltaproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_133424_2 1379698.RBG1_1C00001G0172 2.48e-19 87.4 COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria 2|Bacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_950573_1 469616.FMAG_01331 3.49e-185 522.0 COG3842@1|root,COG3842@2|Bacteria,3788D@32066|Fusobacteria 32066|Fusobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_950573_2 523794.Lebu_1494 2.31e-123 360.0 COG0395@1|root,COG0395@2|Bacteria,37AMC@32066|Fusobacteria 32066|Fusobacteria P ABC transporter, permease protein - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_950573_3 545243.BAEV01000003_gene3342 2.46e-136 396.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,24B75@186801|Clostridia,36HHS@31979|Clostridiaceae 186801|Clostridia G PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_950573_4 935948.KE386495_gene1902 7.79e-40 145.0 COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,248X0@186801|Clostridia,42ESM@68295|Thermoanaerobacterales 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 k59_231433_2 1121403.AUCV01000124_gene2974 8.34e-151 444.0 COG2433@1|root,COG2433@2|Bacteria,1RE5Q@1224|Proteobacteria,42WSA@68525|delta/epsilon subdivisions,2WRPQ@28221|Deltaproteobacteria,2MMJ3@213118|Desulfobacterales 28221|Deltaproteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_1015726_1 323848.Nmul_A0975 2.92e-23 91.7 COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,2VW5A@28216|Betaproteobacteria,373PD@32003|Nitrosomonadales 28216|Betaproteobacteria H Protein of unknown function (DUF2905) - - - - - - - - - - - - DUF2905 k59_1015726_2 1249627.D779_2632 7.63e-14 67.0 2E7X9@1|root,332BU@2|Bacteria,1N7MD@1224|Proteobacteria,1SDFK@1236|Gammaproteobacteria,1WZ93@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_492874_1 1158762.KB898039_gene1702 3.15e-89 276.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1WXCW@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_133431_1 1123008.KB905698_gene3448 1.11e-64 223.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FKYX@200643|Bacteroidia,22W07@171551|Porphyromonadaceae 976|Bacteroidetes P TonB-dependent receptor plug domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec k59_918056_1 439235.Dalk_3301 3.32e-37 135.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MHXJ@213118|Desulfobacterales 28221|Deltaproteobacteria NU PFAM type II secretion system protein E pilT1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_918056_2 56780.SYN_00125 7.18e-23 95.5 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MQ3Y@213462|Syntrophobacterales 28221|Deltaproteobacteria NU PFAM Type II IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_721713_2 335541.Swol_2256 1.97e-188 556.0 COG0610@1|root,COG0610@2|Bacteria,1TP7S@1239|Firmicutes,248A6@186801|Clostridia,42KDX@68298|Syntrophomonadaceae 186801|Clostridia F Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_460366_1 3702.ATCG00510.1 1.63e-13 63.5 2E7JA@1|root,2SE4W@2759|Eukaryota,37XVE@33090|Viridiplantae,3GMGP@35493|Streptophyta 35493|Streptophyta C May help in the organization of the PsaL subunit psaI - - ko:K02696 ko00195,ko01100,map00195,map01100 - - - ko00000,ko00001,ko00194 - - - PSI_8 k59_460366_2 4081.Solyc01g007360.2.1 8.52e-115 330.0 2CNI2@1|root,2QWGG@2759|Eukaryota,37P4I@33090|Viridiplantae,3GGGH@35493|Streptophyta,44MN2@71274|asterids 35493|Streptophyta S Ycf4 ycf4 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0015979,GO:0016043,GO:0019684,GO:0022607,GO:0034622,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048564,GO:0051082,GO:0065003,GO:0071840 - - - - - - - - - - Ycf4 k59_787012_1 760192.Halhy_0390 6.47e-115 347.0 COG3637@1|root,COG3637@2|Bacteria,4NEA6@976|Bacteroidetes,1IREB@117747|Sphingobacteriia 976|Bacteroidetes M RagB SusD domain protein - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_231443_1 1123326.JFBL01000007_gene534 1.62e-66 212.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MR6@68525|delta/epsilon subdivisions,2YNHM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_231443_2 1165841.SULAR_06413 5.59e-35 129.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,42M92@68525|delta/epsilon subdivisions,2YN0J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_263759_2 749222.Nitsa_2120 9.35e-44 152.0 COG0492@1|root,COG0492@2|Bacteria,1NDW6@1224|Proteobacteria,42MUD@68525|delta/epsilon subdivisions,2YMV2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O pyridine nucleotide-disulfide oxidoreductase trxB_2 - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - FixS,Pyr_redox_3 k59_689013_1 50452.W0USV0 0.0 1031.0 28JJ8@1|root,2QRYE@2759|Eukaryota,37RH7@33090|Viridiplantae,3GCW8@35493|Streptophyta,3I0SM@3699|Brassicales 35493|Streptophyta C PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin psaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009941,GO:0009987,GO:0010287,GO:0015979,GO:0016020,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 - ko:K02689 ko00195,ko01100,map00195,map01100 M00163 - - ko00000,ko00001,ko00002,ko00194 - - - PsaA_PsaB k59_721718_1 388413.ALPR1_09965 1.07e-39 147.0 COG0438@1|root,COG0438@2|Bacteria,4NMSN@976|Bacteroidetes,47VYN@768503|Cytophagia 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_427268_2 1410668.JNKC01000005_gene2386 3.63e-34 128.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_231444_1 472759.Nhal_0168 7.61e-93 298.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WVXM@135613|Chromatiales 135613|Chromatiales P heavy metal translocating P-type ATPase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_689015_1 1095769.CAHF01000010_gene1163 1.17e-68 226.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,4728K@75682|Oxalobacteraceae 28216|Betaproteobacteria P Ferrous iron transport protein B C terminus feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_884813_1 1442598.JABW01000030_gene1439 4.39e-05 45.4 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2YMJV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_884813_2 1049564.TevJSym_av00030 3.91e-42 144.0 COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,1S20Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L dihydroneopterin triphosphate nudB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008828,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017144,GO:0018130,GO:0019177,GO:0019438,GO:0019752,GO:0034641,GO:0042364,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0046872,GO:0047429,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.6.1.67 ko:K08310 ko00790,map00790 M00126 R04638 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_1867,iSF_1195.SF1875,iSFxv_1172.SFxv_2099,iS_1188.S1941,iY75_1357.Y75_RS09795,iYL1228.KPN_02379 NUDIX k59_623571_1 1168034.FH5T_16880 6.81e-104 321.0 COG1480@1|root,COG1480@2|Bacteria,4NEHV@976|Bacteroidetes,2FNT9@200643|Bacteroidia 976|Bacteroidetes S 7TM receptor with intracellular HD hydrolase - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_623571_2 172045.KS04_11250 1.69e-13 75.9 COG0793@1|root,COG0793@2|Bacteria,4NFKJ@976|Bacteroidetes,1HXNC@117743|Flavobacteriia,34R0E@308865|Elizabethkingia 976|Bacteroidetes M PDZ domain (Also known as DHR or GLGF) - - - - - - - - - - - - PDZ,PDZ_2,Peptidase_S41 k59_525667_1 332101.JIBU02000012_gene908 1.29e-15 78.2 COG0596@1|root,COG0596@2|Bacteria,1TSPF@1239|Firmicutes,24AD1@186801|Clostridia,36FJN@31979|Clostridiaceae 186801|Clostridia S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_525667_2 195103.CPF_0453 1.1e-27 103.0 COG0346@1|root,COG0346@2|Bacteria,1V6XU@1239|Firmicutes,24JFW@186801|Clostridia,36JVK@31979|Clostridiaceae 186801|Clostridia E glyoxalase bleomycin resistance protein dioxygenase - - - ko:K08234 - - - - ko00000 - - - Glyoxalase k59_590858_2 1439940.BAY1663_04909 6.89e-16 77.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria 1236|Gammaproteobacteria U biopolymer transport protein tolR GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_590858_3 1163617.SCD_n02541 1.8e-64 202.0 COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria 28216|Betaproteobacteria U Mota tolq exbb proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_133443_1 751994.AGIG01000035_gene357 9.05e-118 356.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7VQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F 5'-nucleotidase, C-terminal domain soxB - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_329624_1 1049564.TevJSym_ap00510 4.03e-90 284.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341,ko:K05559 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_623572_1 1249627.D779_0679 1.07e-06 48.9 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1WW0F@135613|Chromatiales 135613|Chromatiales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_623572_2 765911.Thivi_3326 2.23e-29 116.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria,1WVZ1@135613|Chromatiales 135613|Chromatiales KLT kinase domain - - - - - - - - - - - - Pkinase k59_67733_1 572544.Ilyop_0266 1.94e-44 152.0 COG0037@1|root,COG0037@2|Bacteria,378FH@32066|Fusobacteria 32066|Fusobacteria H Belongs to the TtcA family - - - - - - - - - - - - ATP_bind_3 k59_656612_1 156889.Mmc1_1035 7.01e-56 200.0 COG0642@1|root,COG0745@1|root,COG2199@1|root,COG2202@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - EAL,HATPase_c,HisKA,Hpt,NMT1,PAS,PAS_9,Response_reg k59_754119_1 485918.Cpin_1800 3.18e-12 67.4 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_754119_2 1121098.HMPREF1534_00448 4e-07 55.1 COG1435@1|root,COG1435@2|Bacteria,4NGX8@976|Bacteroidetes,2FPJC@200643|Bacteroidia,4ANTP@815|Bacteroidaceae 976|Bacteroidetes F SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_198552_1 572544.Ilyop_0569 3.99e-137 397.0 COG0195@1|root,COG0195@2|Bacteria,378QB@32066|Fusobacteria 32066|Fusobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k59_198552_2 1227268.HMPREF1552_00551 8.86e-39 137.0 COG2740@1|root,COG2740@2|Bacteria,378MG@32066|Fusobacteria 32066|Fusobacteria K Psort location Cytoplasmic, score 8.96 - - - ko:K07742 - - - - ko00000 - - - DUF448,Ribosomal_L7Ae k59_198552_3 572544.Ilyop_0571 0.0 936.0 COG0532@1|root,COG0532@2|Bacteria,378PR@32066|Fusobacteria 32066|Fusobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_198552_4 1319815.HMPREF0202_00578 6.55e-46 151.0 COG0858@1|root,COG0858@2|Bacteria,37A8Q@32066|Fusobacteria 32066|Fusobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_198552_5 572544.Ilyop_0573 1.94e-204 582.0 COG0608@1|root,COG0608@2|Bacteria,378YU@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score - - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_329630_2 1033802.SSPSH_002008 1.69e-15 73.9 COG3151@1|root,COG3151@2|Bacteria,1NAPI@1224|Proteobacteria,1SEY8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1249) - - - ko:K09920 - - - - ko00000 - - - DUF1249 k59_100628_1 1168034.FH5T_00385 1.11e-263 736.0 COG0514@1|root,COG0514@2|Bacteria,4NEFD@976|Bacteroidetes,2FMT4@200643|Bacteroidia 976|Bacteroidetes L ATP-dependent DNA helicase RecQ recQ2 - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecQ_Zn_bind k59_362354_1 338963.Pcar_1079 2.35e-76 236.0 COG0599@1|root,COG0599@2|Bacteria,1QTZH@1224|Proteobacteria,42TJW@68525|delta/epsilon subdivisions,2X5P7@28221|Deltaproteobacteria,43UQ2@69541|Desulfuromonadales 28221|Deltaproteobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_1015753_1 1168034.FH5T_11005 6.25e-106 313.0 COG0136@1|root,COG0136@2|Bacteria,4NE4V@976|Bacteroidetes,2FMHI@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_166165_1 1150621.SMUL_0514 4.52e-39 146.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2YMP5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_623580_1 469618.FVAG_00915 3.76e-151 441.0 COG0252@1|root,COG0252@2|Bacteria,378DK@32066|Fusobacteria 32066|Fusobacteria EJ L-asparaginase, type I - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_362383_51 395961.Cyan7425_3345 4.31e-94 280.0 COG0529@1|root,COG0529@2|Bacteria,1G21C@1117|Cyanobacteria,3KGJR@43988|Cyanothece 1117|Cyanobacteria F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_362383_52 1049564.TevJSym_bj00080 4.46e-119 354.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1J5TV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) rfaC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107 Glyco_transf_9 k59_362383_53 95619.PM1_0201290 1.31e-151 439.0 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,1RQE3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of the first glucose residue to the LPS core rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_transf_4,Glycos_transf_1 k59_362383_54 522306.CAP2UW1_4194 3.84e-89 272.0 COG0515@1|root,COG0515@2|Bacteria,1MXX9@1224|Proteobacteria,2VHSR@28216|Betaproteobacteria,1KR2Y@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core - - - ko:K02848 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005 - - - Kdo k59_362383_55 1112274.KI911560_gene180 1.89e-52 178.0 COG0515@1|root,COG0515@2|Bacteria,1QU0D@1224|Proteobacteria,2VU0E@28216|Betaproteobacteria,2KMSZ@206350|Nitrosomonadales 206350|Nitrosomonadales KLT Lipopolysaccharide kinase (Kdo/WaaP) family - - - - - - - - - - - - Kdo k59_362383_56 1123354.AUDR01000013_gene534 2.36e-84 275.0 COG1718@1|root,COG1718@2|Bacteria,1QY37@1224|Proteobacteria,2VKUD@28216|Betaproteobacteria 28216|Betaproteobacteria DT Lipopolysaccharide kinase (Kdo/WaaP) family - - - - - - - - - - - - Kdo k59_362383_57 1198232.CYCME_0690 0.0 905.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,45ZSA@72273|Thiotrichales 72273|Thiotrichales O PFAM Carbamoyltransferase - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_362383_58 349124.Hhal_2265 1e-39 139.0 COG0250@1|root,COG0250@2|Bacteria,1N01W@1224|Proteobacteria,1S91B@1236|Gammaproteobacteria,1WZ5M@135613|Chromatiales 135613|Chromatiales K Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components rfaH - - ko:K05785 - - - - ko00000,ko03000 - - - NusG k59_362383_60 1121413.JMKT01000003_gene182 1.84e-26 102.0 COG1846@1|root,COG1846@2|Bacteria,1N0TY@1224|Proteobacteria,42V0T@68525|delta/epsilon subdivisions,2WS8F@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Winged helix-turn-helix DNA-binding - - - - - - - - - - - - HTH_24 k59_362383_61 489825.LYNGBM3L_29920 5.28e-156 446.0 COG1089@1|root,COG1089@2|Bacteria,1G2FW@1117|Cyanobacteria,1H7QC@1150|Oscillatoriales 1117|Cyanobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose yefA - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_362383_62 640081.Dsui_0073 2.15e-133 382.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2VIQG@28216|Betaproteobacteria,2KVDT@206389|Rhodocyclales 206389|Rhodocyclales M Nucleotidyl transferase - - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_362383_63 1207075.PputUW4_03902 3.09e-138 404.0 COG0451@1|root,COG0451@2|Bacteria,1MV73@1224|Proteobacteria,1RMKK@1236|Gammaproteobacteria 1236|Gammaproteobacteria M CDP-glucose 4,6-dehydratase rfbG - 4.2.1.45 ko:K01709 ko00520,map00520 - R02426 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_362383_64 640081.Dsui_0071 9.83e-81 244.0 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,2VQ02@28216|Betaproteobacteria,2KUTY@206389|Rhodocyclales 28216|Betaproteobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_362383_65 1123020.AUIE01000001_gene2266 2.1e-212 596.0 COG0500@1|root,COG0500@2|Bacteria,1MVD1@1224|Proteobacteria,1RZDA@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_362383_66 1122605.KB893627_gene2999 2.13e-79 248.0 COG0451@1|root,COG0451@2|Bacteria,4NQXN@976|Bacteroidetes,1IUDB@117747|Sphingobacteriia 976|Bacteroidetes GM GDP-mannose 4,6 dehydratase - - - - - - - - - - - - Epimerase k59_362383_67 118005.AWNK01000003_gene2327 4.48e-61 200.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.222,2.1.1.64 ko:K00568,ko:K20444 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Acyltransferase,Glycos_transf_2,MMPL,Methyltransf_11,Methyltransf_13,Methyltransf_14,Methyltransf_23,Methyltransf_31,TPR_8 k59_787386_1 316055.RPE_3198 1.37e-66 214.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,2U2YW@28211|Alphaproteobacteria,3JYK9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S SBF-like CPA transporter family (DUF4137) - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_787386_2 316055.RPE_3199 8.81e-32 113.0 COG0028@1|root,COG0028@2|Bacteria 2|Bacteria EH Belongs to the TPP enzyme family - - - - - - - - - - - - TPP_enzyme_C k59_820077_1 933262.AXAM01000051_gene2990 2.28e-64 210.0 COG3464@1|root,COG3464@2|Bacteria,1N5CJ@1224|Proteobacteria,43CJ2@68525|delta/epsilon subdivisions,2X7TC@28221|Deltaproteobacteria,2MPPB@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_68097_2 1249627.D779_2564 9.31e-34 117.0 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,1WZDN@135613|Chromatiales 135613|Chromatiales J Belongs to the bacterial ribosomal protein bS21 family rpsU - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_657066_1 313596.RB2501_00896 8.74e-85 271.0 COG3408@1|root,COG3408@2|Bacteria,4NHHR@976|Bacteroidetes,1I003@117743|Flavobacteriia 976|Bacteroidetes G Alpha-L-rhamnosidase N-terminal domain - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_787390_1 1283284.AZUK01000001_gene137 1.96e-126 382.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Alpha amylase catalytic ams - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_198943_1 1121456.ATVA01000013_gene1108 2.35e-14 75.9 COG2198@1|root,COG2198@2|Bacteria,1NWWY@1224|Proteobacteria,43EFH@68525|delta/epsilon subdivisions,2X88P@28221|Deltaproteobacteria,2M8IZ@213115|Desulfovibrionales 28221|Deltaproteobacteria T signal transduction histidine kinase - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - Hpt,STAS_2 k59_198943_2 1392488.JHZY01000004_gene2353 0.000586 44.7 COG3279@1|root,COG3279@2|Bacteria,4NIJQ@976|Bacteroidetes,1HZD8@117743|Flavobacteriia,2XI8J@283735|Leeuwenhoekiella 976|Bacteroidetes T COG3279 Response regulator of the LytR AlgR family - - - - - - - - - - - - LytTR,Response_reg k59_231810_1 631362.Thi970DRAFT_01578 9.76e-48 173.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1WXTS@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3 k59_133913_1 387093.SUN_0122 3.98e-37 132.0 COG3022@1|root,COG3022@2|Bacteria,1Q5IV@1224|Proteobacteria,42QYB@68525|delta/epsilon subdivisions,2YNY3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0246 family - - - ko:K09861 - - - - ko00000 - - - H2O2_YaaD k59_427603_1 501479.ACNW01000062_gene2721 1.82e-84 264.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2U2RS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type sugar transport systems, ATPase components - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_166618_1 388051.AUFE01000003_gene728 1.19e-81 274.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria 28216|Betaproteobacteria M surface antigen variable number repeat protein - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_526102_1 563040.Saut_1577 9.48e-229 644.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H ATP citrate synthase - - 2.3.3.8 ko:K15230 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,Ligase_CoA k59_754482_3 1198232.CYCME_0769 2.35e-57 182.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,4601G@72273|Thiotrichales 72273|Thiotrichales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_918526_1 1117379.BABA_04334 2.41e-12 66.2 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HACS@91061|Bacilli,1ZATG@1386|Bacillus 91061|Bacilli IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.3,6.2.1.48 ko:K00666,ko:K01897,ko:K02182 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_951043_1 1121405.dsmv_2912 3.43e-78 252.0 COG1944@1|root,COG1944@2|Bacteria,1N5NV@1224|Proteobacteria,42P09@68525|delta/epsilon subdivisions,2WK3G@28221|Deltaproteobacteria,2MMSK@213118|Desulfobacterales 28221|Deltaproteobacteria S YcaO cyclodehydratase, ATP-ad Mg2+-binding - - - - - - - - - - - - YcaO k59_1028518_10 768671.ThimaDRAFT_3720 1.58e-131 389.0 COG2270@1|root,COG2270@2|Bacteria,1QX9I@1224|Proteobacteria,1T4WF@1236|Gammaproteobacteria,1X2TX@135613|Chromatiales 135613|Chromatiales S PFAM nucleoside H symporter - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_1028518_11 713586.KB900536_gene77 4.48e-209 584.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1WXNW@135613|Chromatiales 135613|Chromatiales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_1028518_12 2340.JV46_17820 4.82e-112 344.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1J52S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria MU COG1538 Outer membrane protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1028518_14 1049564.TevJSym_ab01910 1.24e-299 831.0 COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter ygaD - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1028518_16 498211.CJA_1331 7.94e-108 354.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1FGIG@10|Cellvibrio 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9 k59_1028518_17 1167006.UWK_03541 8.72e-76 240.0 COG3221@1|root,COG3221@2|Bacteria,1NPBT@1224|Proteobacteria,42NX8@68525|delta/epsilon subdivisions,2WM7I@28221|Deltaproteobacteria,2MIUZ@213118|Desulfobacterales 28221|Deltaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_997009_1 933262.AXAM01000018_gene974 5.02e-61 205.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MJE7@213118|Desulfobacterales 28221|Deltaproteobacteria NU General secretory system II protein E domain protein - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_10685_1 387093.SUN_1964 1.2e-113 341.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2YMA3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_865178_1 1226994.AMZB01000124_gene3017 5.83e-38 137.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1YCWB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) rfaC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107 Glyco_transf_9 k59_865178_2 582744.Msip34_1891 4.01e-54 180.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,2KM3T@206350|Nitrosomonadales 206350|Nitrosomonadales M TIGRFAM lipopolysaccharide heptosyltransferase II - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_473036_3 395019.Bmul_0912 8.73e-56 187.0 COG5635@1|root,COG5635@2|Bacteria,1N7XU@1224|Proteobacteria 1224|Proteobacteria T Nacht domain - - - - - - - - - - - - DUF4062 k59_375540_1 1168034.FH5T_07265 5.84e-78 251.0 COG4206@1|root,COG4206@2|Bacteria,4NHH8@976|Bacteroidetes,2FM70@200643|Bacteroidia 976|Bacteroidetes H COG COG4771 Outer membrane receptor for ferrienterochelin and colicins - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_833039_1 264732.Moth_0440 6.71e-16 80.5 COG2048@1|root,COG2048@2|Bacteria,1V67B@1239|Firmicutes,248DI@186801|Clostridia,42H12@68295|Thermoanaerobacterales 186801|Clostridia C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_1028526_1 1168034.FH5T_11925 1.08e-47 167.0 COG0849@1|root,COG0849@2|Bacteria,4NE0V@976|Bacteroidetes,2FMUG@200643|Bacteroidia 976|Bacteroidetes D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_1028526_2 1168034.FH5T_11930 4.9e-07 50.4 COG0206@1|root,COG0206@2|Bacteria,4NF8N@976|Bacteroidetes,2FMJV@200643|Bacteroidia 976|Bacteroidetes D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_796890_1 1121939.L861_00600 0.00044 48.5 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XICI@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04691,ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_898430_1 316273.XCV1066 6.47e-10 58.9 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1X5K2@135614|Xanthomonadales 135614|Xanthomonadales S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_898430_2 379731.PST_2051 3.11e-75 231.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1Z0V2@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_81090_1 1415756.JQMY01000001_gene3407 4.55e-60 204.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,2PF9S@252301|Oceanicola 28211|Alphaproteobacteria G Transketolase, thiamine diphosphate binding domain cbbT - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_81090_2 1123237.Salmuc_04598 6.84e-14 70.1 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_46739_2 583355.Caka_2358 7.9e-76 243.0 COG3137@1|root,COG3137@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF481 k59_244503_1 1249480.B649_00450 2.31e-41 137.0 COG0268@1|root,COG0268@2|Bacteria,1NITA@1224|Proteobacteria,42V4U@68525|delta/epsilon subdivisions,2YPUG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_244503_2 563040.Saut_2123 2.47e-24 100.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2YMD9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_898446_1 935548.KI912159_gene1923 1.74e-85 260.0 COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,43PQD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Ubie_methyltran k59_605056_1 1089548.KI783301_gene732 1.57e-125 383.0 COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4HC9J@91061|Bacilli,3WDVN@539002|Bacillales incertae sedis 91061|Bacilli S Endoribonuclease that initiates mRNA decay rny GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_605062_1 1157490.EL26_22810 1.4e-70 222.0 COG2043@1|root,COG2043@2|Bacteria,1TT5P@1239|Firmicutes,4HFED@91061|Bacilli,2796U@186823|Alicyclobacillaceae 91061|Bacilli S Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 k59_46772_1 768671.ThimaDRAFT_4269 1.09e-88 271.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RY2H@1236|Gammaproteobacteria,1WX0H@135613|Chromatiales 135613|Chromatiales GM epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_931745_1 709032.Sulku_0432 1.37e-44 163.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2YMW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1028556_2 1382306.JNIM01000001_gene4079 8.09e-127 391.0 COG0595@1|root,COG0595@2|Bacteria,2G611@200795|Chloroflexi 200795|Chloroflexi S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,RMMBL k59_1028556_3 1460634.JCM19037_2790 1.08e-13 79.3 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli 91061|Bacilli E ABC transporter substrate-binding protein - - - - - - - - - - - - SBP_bac_5 k59_375571_1 509635.N824_20000 5.5e-43 159.0 COG2010@1|root,COG2010@2|Bacteria,4NEPV@976|Bacteroidetes,1IPAR@117747|Sphingobacteriia 976|Bacteroidetes C Protein of unknown function (DUF1553) - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_344125_1 2340.JV46_10170 2.18e-22 94.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1J545@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - iJN746.PP_4253 Cytochrome_CBB3,FixP_N k59_148460_1 314292.VAS14_20826 1.39e-63 206.0 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,1XSUQ@135623|Vibrionales 135623|Vibrionales H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 ygdL - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_473649_1 1158345.JNLL01000001_gene1838 2.81e-28 116.0 COG1672@1|root,COG1672@2|Bacteria 2|Bacteria - - cyoE - - ko:K06921 - - - - ko00000 - - - ATPase_2 k59_734566_1 685778.AORL01000010_gene2659 6.49e-24 104.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2TS31@28211|Alphaproteobacteria,2K1MM@204457|Sphingomonadales 204457|Sphingomonadales C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex bkdB - 2.3.1.168 ko:K09699 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R02662,R03174,R04097,R10998 RC00004,RC02727,RC02870 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_734566_2 1123257.AUFV01000010_gene3203 2.78e-140 404.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1X44Z@135614|Xanthomonadales 135614|Xanthomonadales C Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit pdhB - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_768188_1 1168034.FH5T_12085 1.88e-100 302.0 COG0104@1|root,COG0104@2|Bacteria,4NGRZ@976|Bacteroidetes,2FM8A@200643|Bacteroidia 976|Bacteroidetes F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_768188_2 1087448.Eab7_2626 7.7e-28 114.0 COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,4HAI4@91061|Bacilli,3WEA1@539002|Bacillales incertae sedis 91061|Bacilli H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase k59_572569_1 1052684.PPM_3217 4.14e-73 249.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_540569_1 1121405.dsmv_3083 1.04e-59 196.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2MI8E@213118|Desulfobacterales 28221|Deltaproteobacteria J Protein of unknown function (DUF933) - - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_309869_1 1548153.LR59_00005 3.94e-51 179.0 COG3563@1|root,COG3563@2|Bacteria,1MW0T@1224|Proteobacteria,42PXV@68525|delta/epsilon subdivisions,2YN4A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M polysaccharide export protein KPSC kpsC - - ko:K07266 - - - - ko00000 - - - Capsule_synth k59_671200_2 1485545.JQLW01000005_gene1092 6.88e-90 291.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria 1224|Proteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07239,ko:K15726 - - - - ko00000,ko02000 2.A.6.1,2.A.6.1.2 - - ACR_tran k59_638139_1 1168034.FH5T_20990 8.18e-115 336.0 COG0668@1|root,COG0668@2|Bacteria,4NEPW@976|Bacteroidetes,2G3EE@200643|Bacteroidia 2|Bacteria M mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_508358_1 158189.SpiBuddy_1592 1.57e-79 256.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6JA@203691|Spirochaetes 203691|Spirochaetes C PFAM Iron only hydrogenase large subunit, C-terminal domain - - 1.12.1.3,1.17.99.7,1.6.5.3 ko:K00336,ko:K18332,ko:K22015 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_932296_1 338963.Pcar_2039 4.26e-53 186.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,43RX7@69541|Desulfuromonadales 28221|Deltaproteobacteria J Ribonuclease E/G family rne - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_797505_1 929558.SMGD1_2193 3.83e-106 314.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42PF7@68525|delta/epsilon subdivisions,2YM9X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the ParA family flhG - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,ParA k59_797505_2 563040.Saut_0713 4.95e-06 47.4 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,42NBF@68525|delta/epsilon subdivisions,2YN28@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar biosynthesis flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_997688_1 509190.Cseg_1483 1.37e-60 212.0 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2KFWJ@204458|Caulobacterales 204458|Caulobacterales P TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_540575_1 935863.AWZR01000001_gene1626 1.44e-07 58.2 COG3595@1|root,COG3595@2|Bacteria,1N10U@1224|Proteobacteria,1S8T2@1236|Gammaproteobacteria,1X5XN@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_540575_2 886293.Sinac_5243 4.12e-20 88.2 COG0115@1|root,COG0115@2|Bacteria,2J2GT@203682|Planctomycetes 203682|Planctomycetes H Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_309901_1 477228.YO5_03687 3.94e-59 188.0 COG0386@1|root,COG0386@2|Bacteria,1PY6H@1224|Proteobacteria,1SNWD@1236|Gammaproteobacteria,1Z050@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_899146_1 749222.Nitsa_0195 7.74e-95 284.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,42P86@68525|delta/epsilon subdivisions,2YN53@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - iIT341.HP1418 MurB_C k59_309909_1 709032.Sulku_1823 1.09e-34 127.0 COG0697@1|root,COG0697@2|Bacteria,1R8RU@1224|Proteobacteria,42SDJ@68525|delta/epsilon subdivisions,2YPDW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_309909_2 425104.Ssed_2272 9.31e-36 131.0 COG1073@1|root,COG1073@2|Bacteria,1RBII@1224|Proteobacteria,1RWRQ@1236|Gammaproteobacteria,2QCN0@267890|Shewanellaceae 1236|Gammaproteobacteria S Alpha/beta hydrolase family - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_638154_1 1122137.AQXF01000002_gene194 8.44e-111 332.0 COG0312@1|root,COG0312@2|Bacteria 2|Bacteria S metallopeptidase activity tldD3 - - - - - - - - - - - PmbA_TldD k59_734593_1 1168034.FH5T_21310 1.84e-61 215.0 COG1674@1|root,COG1674@2|Bacteria,4NE86@976|Bacteroidetes,2FMX0@200643|Bacteroidia 976|Bacteroidetes D FtsK SpoIIIE family protein ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_508389_1 1335757.SPICUR_06695 2.83e-149 445.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_181077_1 172088.AUGA01000064_gene7510 7.96e-15 84.3 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,3JRJK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Penicillin-binding protein OB-like domain mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_734600_1 208439.AJAP_19400 3.19e-15 75.1 COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4E14X@85010|Pseudonocardiales 201174|Actinobacteria KT helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_734600_2 1105031.HMPREF1141_0075 5.18e-10 65.9 COG2972@1|root,COG2972@2|Bacteria,1V0SG@1239|Firmicutes,249FK@186801|Clostridia,36KBK@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase,dCache_1 k59_638161_1 765910.MARPU_14675 1.23e-98 303.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales 135613|Chromatiales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_11331_1 1168034.FH5T_06945 1.51e-60 195.0 COG2518@1|root,COG2518@2|Bacteria,4NMTP@976|Bacteroidetes,2FXTG@200643|Bacteroidia 976|Bacteroidetes O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_11331_2 1168034.FH5T_05930 5.89e-23 97.8 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,2FMH3@200643|Bacteroidia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran,OEP k59_638163_2 1244083.CSUNSWCD_1370 4.67e-26 99.0 COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,42VB5@68525|delta/epsilon subdivisions,2YPVJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S of the cytoplasmic domain of flagellar protein FhlB flhB2 - - ko:K04061 - - - - ko00000,ko02044 - - - Bac_export_2 k59_638163_3 1537917.JU82_04980 9.11e-38 137.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,42N4K@68525|delta/epsilon subdivisions,2YMXB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_964471_2 1267005.KB911260_gene3483 1.32e-25 104.0 COG1376@1|root,COG1376@2|Bacteria,1MUAB@1224|Proteobacteria,2TTXM@28211|Alphaproteobacteria 28211|Alphaproteobacteria L ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD k59_508393_1 1120970.AUBZ01000019_gene3563 1.12e-90 279.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,465AR@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nrtC - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_344781_1 439235.Dalk_5256 1.15e-136 399.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MNIW@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_276402_1 1123401.JHYQ01000001_gene1825 1.82e-33 116.0 COG3514@1|root,COG3514@2|Bacteria,1NAV1@1224|Proteobacteria,1S9TK@1236|Gammaproteobacteria,463K8@72273|Thiotrichales 72273|Thiotrichales S CopG antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_81829_1 113355.CM001775_gene377 1.48e-55 186.0 COG3900@1|root,COG3900@2|Bacteria,1G5FF@1117|Cyanobacteria 1117|Cyanobacteria S periplasmic protein (DUF2092) - - - - - - - - - - - - DUF2092 k59_213551_1 1042326.AZNV01000029_gene3564 5.1e-84 260.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria,4B8WN@82115|Rhizobiaceae 28211|Alphaproteobacteria C Zinc-binding dehydrogenase - GO:0001505,GO:0003008,GO:0003674,GO:0003824,GO:0004022,GO:0004552,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0007610,GO:0007611,GO:0007612,GO:0007632,GO:0008150,GO:0008152,GO:0008306,GO:0008542,GO:0009314,GO:0009416,GO:0009628,GO:0016491,GO:0016614,GO:0016616,GO:0016651,GO:0016657,GO:0019222,GO:0031323,GO:0031399,GO:0032268,GO:0032501,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050877,GO:0050890,GO:0050896,GO:0051171,GO:0051246,GO:0051903,GO:0055114,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080007,GO:0080090,GO:0080164,GO:1901615,GO:2000169,GO:2000377 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_408484_2 1168034.FH5T_17540 2.22e-134 386.0 COG4105@1|root,COG4105@2|Bacteria,4NJ5A@976|Bacteroidetes,2FNAY@200643|Bacteroidia 976|Bacteroidetes S outer membrane assembly lipoprotein YfiO yfiO - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_968881_1 1056820.KB900652_gene3349 8.06e-11 63.5 COG1017@1|root,COG1017@2|Bacteria,1NA56@1224|Proteobacteria,1SDRC@1236|Gammaproteobacteria,2PP31@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C nitric oxide dioxygenase activity VPA1107 - - - - - - - - - - - - k59_478011_1 588581.Cpap_0010 6.97e-34 138.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria 2|Bacteria IQ oxidoreductase activity - - - ko:K13612,ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - ADH_N,ADH_zinc_N,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_412751_1 1355368.JART01000016_gene1967 3.39e-96 291.0 28M05@1|root,2ZB16@2|Bacteria,1QVZ0@1224|Proteobacteria,43D1M@68525|delta/epsilon subdivisions,2YTF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_412751_2 387093.SUN_1198 3.94e-27 107.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2YN0I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS k59_576975_1 563040.Saut_0515 3.53e-129 375.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,42NRV@68525|delta/epsilon subdivisions,2YMK2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_349660_2 1229485.AMYV01000052_gene1563 3.42e-11 58.5 COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,1S8S1@1236|Gammaproteobacteria,1J7AQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG1977 Molybdopterin converting factor, small subunit moaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - iE2348C_1286.E2348C_0736,iEC55989_1330.EC55989_0827,iG2583_1286.G2583_1012,iLF82_1304.LF82_1368,iNRG857_1313.NRG857_03495,iSFV_1184.SFV_0767,iSF_1195.SF0734,iSFxv_1172.SFxv_0800,iSSON_1240.SSON_0763,iS_1188.S0775 ThiS k59_153327_1 925409.KI911562_gene1378 6.85e-40 150.0 COG4447@1|root,COG4447@2|Bacteria,4NK01@976|Bacteroidetes,1IWVG@117747|Sphingobacteriia 976|Bacteroidetes T Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_838471_1 933262.AXAM01000022_gene3241 1.78e-67 231.0 COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales 28221|Deltaproteobacteria IQ TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA - - - - - - - - - - - - Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_642987_2 765912.Thimo_2445 1e-25 103.0 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1WXHE@135613|Chromatiales 135613|Chromatiales M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_218327_1 926562.Oweho_3043 1.81e-53 182.0 COG1668@1|root,COG1668@2|Bacteria,4NFSZ@976|Bacteroidetes,1HXQA@117743|Flavobacteriia,2PAWK@246874|Cryomorphaceae 976|Bacteroidetes CP ABC-2 family transporter protein natB - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_218327_2 886379.AEWI01000005_gene970 1.32e-16 79.0 COG0248@1|root,COG0248@2|Bacteria,4NEI0@976|Bacteroidetes,2FN6C@200643|Bacteroidia,3XJF5@558415|Marinilabiliaceae 976|Bacteroidetes FP Ppx/GppA phosphatase family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_802427_2 563040.Saut_0230 3.09e-55 177.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,42NSE@68525|delta/epsilon subdivisions,2YMUG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_381107_1 1150469.RSPPHO_02557 5.72e-72 234.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2JSY5@204441|Rhodospirillales 204441|Rhodospirillales C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_610381_1 414684.RC1_1593 1.37e-109 330.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPSC@204441|Rhodospirillales 204441|Rhodospirillales C belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_707897_1 572544.Ilyop_0818 4.22e-62 202.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups gtf1 GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758 2.4.1.52 ko:K00712 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_A_1,Glycos_transf_1 k59_937186_1 1236514.BAKL01000006_gene742 6.38e-51 180.0 COG1331@1|root,COG1331@2|Bacteria,4NSMA@976|Bacteroidetes,2FP32@200643|Bacteroidia,4ANH7@815|Bacteroidaceae 976|Bacteroidetes O Pectic acid lyase - - - - - - - - - - - - Pec_lyase k59_676397_1 96561.Dole_2140 3.58e-73 239.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,Radical_SAM k59_903896_1 278957.ABEA03000186_gene1540 4.28e-22 95.1 COG0277@1|root,COG0277@2|Bacteria,46Y87@74201|Verrucomicrobia,3K93M@414999|Opitutae 414999|Opitutae C FAD linked oxidases, C-terminal domain - - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_52113_1 765912.Thimo_0453 1.26e-52 169.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_739194_1 1403819.BATR01000040_gene1207 8.61e-55 192.0 COG0654@1|root,COG2020@1|root,COG0654@2|Bacteria,COG2020@2|Bacteria,46VIV@74201|Verrucomicrobia,2IWBP@203494|Verrucomicrobiae 203494|Verrucomicrobiae CH FAD binding domain - - - - - - - - - - - - FAD_binding_3 k59_513286_2 1168034.FH5T_05135 1.58e-80 245.0 COG4760@1|root,COG4760@2|Bacteria,4NNIN@976|Bacteroidetes 976|Bacteroidetes S membrane - - - - - - - - - - - - BaxI_1 k59_16456_1 1313421.JHBV01000004_gene760 1.02e-11 65.5 COG1285@1|root,COG1285@2|Bacteria,4NTPJ@976|Bacteroidetes 976|Bacteroidetes S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 k59_676411_1 870187.Thini_4246 1.54e-40 153.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3 k59_281241_1 1038866.KB902809_gene2493 7.04e-10 59.3 28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,2TU05@28211|Alphaproteobacteria,3JS0Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - MA20_08580 - - - - - - - - - - - Endostatin k59_281241_2 1266908.AQPB01000060_gene347 3.75e-15 76.6 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales 135613|Chromatiales K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,DUF3335 k59_773113_1 648757.Rvan_0558 3.07e-62 211.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,3N65P@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_903913_1 391615.ABSJ01000039_gene1854 1.15e-52 177.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1J4Z6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_838507_1 1232683.ADIMK_3896 2.17e-58 192.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1T245@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_802458_1 572477.Alvin_2184 7.06e-111 341.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_610409_1 572544.Ilyop_1339 2.86e-58 194.0 COG1283@1|root,COG1283@2|Bacteria,378CQ@32066|Fusobacteria 32066|Fusobacteria P Na Pi-cotransporter II-like protein - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_478511_1 1304888.ATWF01000001_gene1900 4.24e-10 57.4 COG5336@1|root,COG5336@2|Bacteria,2GG0Q@200930|Deferribacteres 200930|Deferribacteres S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_478511_2 96561.Dole_0627 1.14e-17 81.3 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria,2MKD4@213118|Desulfobacterales 28221|Deltaproteobacteria C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_349692_1 1384056.N787_04435 7.59e-92 280.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RVZ6@1236|Gammaproteobacteria,1XCIP@135614|Xanthomonadales 135614|Xanthomonadales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine - - - - - - - - - - - - SUA5,Sua5_yciO_yrdC k59_773131_1 886379.AEWI01000091_gene1610 1.14e-144 422.0 COG5659@1|root,COG5659@2|Bacteria,4NQCF@976|Bacteroidetes,2FXFH@200643|Bacteroidia 976|Bacteroidetes L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_478512_2 666685.R2APBS1_3849 5.03e-28 107.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1X3TD@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_52142_1 1168034.FH5T_07040 3.06e-179 522.0 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,2FN30@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrd - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_676438_1 1385420.FRA_34c06300 1.55e-92 274.0 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,460IX@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose - - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_577520_1 1442598.JABW01000008_gene732 4.37e-108 318.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,42MAB@68525|delta/epsilon subdivisions,2YN34@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_937236_1 469618.FVAG_00327 2.92e-105 313.0 COG1101@1|root,COG1101@2|Bacteria,378KE@32066|Fusobacteria 32066|Fusobacteria S ABC transporter - - - ko:K05833 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_tran k59_937236_2 393480.FNP_2380 1.82e-95 290.0 COG4120@1|root,COG4120@2|Bacteria,378SN@32066|Fusobacteria 32066|Fusobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K05832 - M00247 - - ko00000,ko00002,ko02000 - - - BPD_transp_2 k59_937236_3 536227.CcarbDRAFT_1253 6.6e-109 325.0 COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,36EB5@31979|Clostridiaceae 186801|Clostridia S ABC transporter - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_281283_1 1168034.FH5T_11360 6.62e-112 338.0 COG1502@1|root,COG1502@2|Bacteria,4NE2W@976|Bacteroidetes,2FMEA@200643|Bacteroidia 976|Bacteroidetes I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_903939_1 266835.14022106 5.64e-65 212.0 COG0477@1|root,2Z82B@2|Bacteria,1R9GD@1224|Proteobacteria,2TTIS@28211|Alphaproteobacteria,43J6X@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_413240_1 761193.Runsl_1403 7.73e-48 163.0 COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,47KW5@768503|Cytophagia 976|Bacteroidetes S PFAM Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_773165_1 378806.STAUR_0675 6.67e-82 264.0 COG5337@1|root,COG5337@2|Bacteria,1QCJ4@1224|Proteobacteria,42QGZ@68525|delta/epsilon subdivisions,2WKE6@28221|Deltaproteobacteria,2YYP7@29|Myxococcales 28221|Deltaproteobacteria M CotH kinase protein - - - - - - - - - - - - CotH k59_52164_1 1168034.FH5T_02805 2.74e-73 228.0 COG0697@1|root,COG0697@2|Bacteria,4NH9M@976|Bacteroidetes,2FPTW@200643|Bacteroidia 976|Bacteroidetes EG membrane - - - - - - - - - - - - EamA k59_52164_2 1168034.FH5T_02800 4.28e-91 268.0 COG2030@1|root,COG2030@2|Bacteria,4NNHH@976|Bacteroidetes,2FP51@200643|Bacteroidia 976|Bacteroidetes I MaoC-like protein nodN - - - - - - - - - - - MaoC_dehydratas k59_445642_1 1335757.SPICUR_04860 5.11e-27 103.0 COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,1SD91@1236|Gammaproteobacteria,1X23R@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 k59_314769_1 765914.ThisiDRAFT_0209 7.08e-34 126.0 COG0688@1|root,COG0688@2|Bacteria 2|Bacteria I phosphatidylethanolamine metabolic process psd GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_903948_1 159087.Daro_2284 6.82e-40 134.0 COG2963@1|root,COG2963@2|Bacteria,1N06K@1224|Proteobacteria,2VUF3@28216|Betaproteobacteria,2KZ7Q@206389|Rhodocyclales 206389|Rhodocyclales L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_903948_2 1219035.NT2_12_00990 2.21e-12 63.2 COG2801@1|root,COG3328@1|root,COG2801@2|Bacteria,COG3328@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07497 - - - - ko00000 - - - Transposase_mut,rve,rve_3 k59_545180_1 1049564.TevJSym_ab00620 2.96e-76 239.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1J5BC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II IV02_28760 - - - - - - - - - - - Aminotran_1_2 k59_513335_1 1168034.FH5T_11870 9.39e-48 157.0 COG2001@1|root,COG2001@2|Bacteria,4NM4X@976|Bacteroidetes,2FQMY@200643|Bacteroidia 976|Bacteroidetes K Belongs to the MraZ family mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_513335_2 1168034.FH5T_11865 4.74e-44 151.0 COG0204@1|root,COG0204@2|Bacteria,4NF25@976|Bacteroidetes,2FNJQ@200643|Bacteroidia 976|Bacteroidetes I Acyl-transferase - - - - - - - - - - - - Acyltransferase k59_478539_1 441620.Mpop_3223 8.05e-48 166.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TTE1@28211|Alphaproteobacteria,1JT8D@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_577541_2 1049564.TevJSym_ab00650 5.76e-42 152.0 COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S serine threonine protein kinase ppkA - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - VWA,VWA_2 k59_413250_1 926556.Echvi_4317 1.58e-52 190.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,47YE9@768503|Cytophagia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_16500_1 870187.Thini_1237 3.54e-71 227.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,45ZTP@72273|Thiotrichales 72273|Thiotrichales S Flavocytochrome c sulphide dehydrogenase, flavin-binding - - 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2 k59_1002600_1 1379698.RBG1_1C00001G0894 3.87e-60 199.0 COG1775@1|root,COG1775@2|Bacteria,2NRF8@2323|unclassified Bacteria 2|Bacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_643093_1 743718.Isova_1047 3.71e-49 175.0 28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_16504_1 985665.HPL003_02165 6.05e-23 94.7 COG1846@1|root,COG1846@2|Bacteria,1VCB7@1239|Firmicutes 1239|Firmicutes K Transcriptional - - - - - - - - - - - - MarR,MarR_2 k59_739255_2 867845.KI911784_gene3678 5.04e-121 380.0 COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi,374YG@32061|Chloroflexia 32061|Chloroflexia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_478554_2 412597.AEPN01000076_gene1373 1.85e-23 97.1 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2TSZM@28211|Alphaproteobacteria,2PVIY@265|Paracoccus 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_739258_1 1168034.FH5T_11625 4.43e-82 251.0 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination - - - - - - - - - - - - EamA k59_545198_1 153721.MYP_2680 1.2e-14 78.6 COG1208@1|root,COG4412@1|root,COG1208@2|Bacteria,COG4412@2|Bacteria,4NI02@976|Bacteroidetes,47RAY@768503|Cytophagia 976|Bacteroidetes JM N-acetylglucosamine-1-phosphate uridyltransferase - - - - - - - - - - - - BACON,DUF4859 k59_1002609_1 690850.Desaf_2330 2.51e-21 86.7 2B3E9@1|root,31W34@2|Bacteria,1MZ95@1224|Proteobacteria,42U85@68525|delta/epsilon subdivisions,2WQIR@28221|Deltaproteobacteria,2MCCW@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_643106_1 326297.Sama_0961 9.64e-123 379.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,2Q9V4@267890|Shewanellaceae 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_676502_1 649638.Trad_0194 4.06e-10 67.0 COG4663@1|root,COG4663@2|Bacteria,1WJJU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_937287_1 395494.Galf_1957 3.98e-130 383.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,2VW9J@28216|Betaproteobacteria 28216|Betaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_937287_2 661367.LLO_4081 2.19e-32 118.0 2EC13@1|root,3360B@2|Bacteria,1NG6Q@1224|Proteobacteria,1SEDP@1236|Gammaproteobacteria,1JEWR@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - k59_937287_3 402626.Rpic_3199 1.22e-09 56.6 2EE35@1|root,33E1B@2|Bacteria,1NKKN@1224|Proteobacteria,2WG6K@28216|Betaproteobacteria,1KBDZ@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_937287_4 1120977.JHUX01000003_gene843 4.81e-19 91.3 COG3935@1|root,COG3935@2|Bacteria,1NIEW@1224|Proteobacteria 1224|Proteobacteria L DnaD domain protein - - - - - - - - - - - - - k59_17196_2 290402.Cbei_3494 9.15e-27 107.0 COG0384@1|root,COG0384@2|Bacteria,1TRAF@1239|Firmicutes,25D2F@186801|Clostridia,36DVZ@31979|Clostridiaceae 186801|Clostridia S Phenazine biosynthesis protein, PhzF family - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF k59_387818_2 387093.SUN_1406 4.21e-21 88.2 COG0526@1|root,COG0526@2|Bacteria,1N0R9@1224|Proteobacteria,42VVX@68525|delta/epsilon subdivisions,2YQGM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_483685_1 1297570.MESS4_240036 3.38e-71 225.0 28M1B@1|root,2ZAG6@2|Bacteria,1R4TW@1224|Proteobacteria,2TTPC@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - YkuD_2 k59_779140_1 1408437.JNJN01000011_gene1154 3.32e-31 117.0 COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,24AF7@186801|Clostridia 186801|Clostridia G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) iolE - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_1008172_1 765912.Thimo_1248 1.67e-45 160.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales 135613|Chromatiales S PFAM Peptidoglycan-binding lysin domain - - - - - - - - - - - - LysM k59_583766_1 1282876.BAOK01000001_gene2774 2.1e-46 164.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TQXH@28211|Alphaproteobacteria,4BQU5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_22593_1 1049564.TevJSym_aj00750 2.13e-12 74.7 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J9H4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function (DUF1631) ykoW - - - - - - - - - - - DUF1631,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_1008173_1 1304275.C41B8_15872 6.11e-92 293.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_649108_1 1121013.P873_12090 8.67e-64 211.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1X8AF@135614|Xanthomonadales 135614|Xanthomonadales S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_713862_2 247633.GP2143_08334 3.11e-22 95.5 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1J4IC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_418852_1 452662.SJA_C1-09040 9.47e-31 114.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,2K206@204457|Sphingomonadales 204457|Sphingomonadales S COG2041 Sulfite oxidase and related enzymes - - - - - - - - - - - - Oxidored_molyb k59_418852_2 1120970.AUBZ01000007_gene3002 6.28e-13 68.6 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNFK@1236|Gammaproteobacteria,4647A@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K07641 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_160143_1 1168034.FH5T_12665 3.73e-73 241.0 COG0210@1|root,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,2FNIM@200643|Bacteroidia 976|Bacteroidetes L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1040463_1 367737.Abu_1774 1.38e-149 435.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2YMRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_1040463_3 1249480.B649_06530 1.85e-111 333.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,42MNG@68525|delta/epsilon subdivisions,2YNM4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation - - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_616413_1 1288826.MSNKSG1_00581 1.36e-39 132.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,467T8@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_483694_1 385682.AFSL01000008_gene2621 1.27e-164 476.0 COG0702@1|root,COG0702@2|Bacteria,4NFWH@976|Bacteroidetes,2FPBZ@200643|Bacteroidia 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_745041_1 765912.Thimo_2753 6.24e-07 49.3 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1WXYG@135613|Chromatiales 135613|Chromatiales Q PFAM Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_943180_2 1335760.ASTG01000005_gene1036 2.44e-21 93.6 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,2K074@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_483699_1 983917.RGE_43340 8.28e-41 150.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,1KJYM@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_452489_1 768706.Desor_4116 2.46e-51 185.0 COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,24CKX@186801|Clostridia,26100@186807|Peptococcaceae 186801|Clostridia S Hemerythrin HHE cation binding domain - - - ko:K09155 - - - - ko00000 - - - DUF1858,DUF438,Hemerythrin,PAS_10 k59_943184_1 690850.Desaf_0478 9.9e-53 189.0 COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria,42UE9@68525|delta/epsilon subdivisions,2WR5R@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_224341_1 1121405.dsmv_2444 7.53e-102 310.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria,2MIA7@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase - - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_713874_1 1165841.SULAR_00060 3.25e-64 217.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2YMAI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_387832_1 190650.CC_3499 6.12e-05 47.8 2AA4J@1|root,30ZDH@2|Bacteria,1NKJ2@1224|Proteobacteria,2UK6J@28211|Alphaproteobacteria,2KJK0@204458|Caulobacterales 204458|Caulobacterales - - - - - - - - - - - - - - - k59_551592_1 1188252.AJYK01000060_gene1887 1.57e-06 52.8 COG1309@1|root,COG1309@2|Bacteria,1N0GT@1224|Proteobacteria,1SA00@1236|Gammaproteobacteria,1XVJ8@135623|Vibrionales 135623|Vibrionales K Transcriptional regulator - - - ko:K18136 ko01501,map01501 - - - ko00000,ko00001,ko03000 - - - TetR_C_10,TetR_N k59_519687_1 926561.KB900617_gene2161 8.41e-07 53.5 COG1261@1|root,COG1261@2|Bacteria,1V49J@1239|Firmicutes,24T5Q@186801|Clostridia,3WAVZ@53433|Halanaerobiales 186801|Clostridia N TIGRFAM flagella basal body P-ring formation protein FlgA - - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA k59_126032_2 1173022.Cri9333_0509 5.04e-47 166.0 COG3267@1|root,COG3267@2|Bacteria 2|Bacteria - - exeA - - - - - - - - - - - AAA_22 k59_387835_1 1465751.W8QF12_9VIRU 4.2e-139 426.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA polymerase family B - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004527,GO:0004540,GO:0005575,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018130,GO:0018995,GO:0019058,GO:0019079,GO:0019438,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0042025,GO:0042221,GO:0043170,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0050896,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902074 - - - - - - - - - - - k59_943196_1 1168067.JAGP01000001_gene105 1.84e-69 226.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,460ZZ@72273|Thiotrichales 72273|Thiotrichales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_551599_1 709032.Sulku_1574 3.82e-123 367.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1008197_1 395493.BegalDRAFT_3457 1.04e-12 68.2 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,45ZYD@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_1008197_2 1123073.KB899242_gene975 1.63e-05 50.1 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1X5IM@135614|Xanthomonadales 135614|Xanthomonadales NU type IV pilus biogenesis stability protein PilW pilF - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - TPR_10,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8 k59_583806_1 879212.DespoDRAFT_02068 3.92e-56 196.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,PAS,Response_reg,dCache_1 k59_191982_1 644076.SCH4B_1136 7.57e-23 103.0 COG1178@1|root,COG1178@2|Bacteria,1R0MN@1224|Proteobacteria,2VFDY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P binding-protein-dependent transport systems inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_191982_2 1121936.AUHI01000006_gene2106 3.14e-14 73.2 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,4H9MS@91061|Bacilli 91061|Bacilli P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_745056_1 754477.Q7C_1002 9.67e-67 220.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria,460CE@72273|Thiotrichales 72273|Thiotrichales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_745056_2 765914.ThisiDRAFT_1725 5.25e-119 352.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_126140_43 1288826.MSNKSG1_07758 1.74e-79 239.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,466DM@72275|Alteromonadaceae 1236|Gammaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_126140_44 1129794.C427_2042 4.08e-54 181.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,466F4@72275|Alteromonadaceae 1236|Gammaproteobacteria S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - iE2348C_1286.E2348C_0457 Metallophos,Metallophos_2 k59_126140_45 1121024.AUCD01000001_gene1641 2.92e-42 172.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,27FB8@186828|Carnobacteriaceae 91061|Bacilli KLT Protein tyrosine kinase prkC GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_126140_46 1121403.AUCV01000033_gene3672 9.54e-37 127.0 COG3952@1|root,COG3952@2|Bacteria,1NFUX@1224|Proteobacteria 1224|Proteobacteria S membrane - - - - - - - - - - - - LAB_N k59_126140_47 243233.MCA0374 4.03e-98 293.0 COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,1S22P@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis dpm1 - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_126140_48 401526.TcarDRAFT_1133 6.83e-40 160.0 COG1807@1|root,COG1807@2|Bacteria,1UY16@1239|Firmicutes,4H35V@909932|Negativicutes 909932|Negativicutes M dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_126140_49 743722.Sph21_2152 3.83e-28 122.0 COG3258@1|root,COG3258@2|Bacteria,4NGIH@976|Bacteroidetes,1IXIN@117747|Sphingobacteriia 976|Bacteroidetes C Cytochrome C oxidase, cbb3-type, subunit III - - 1.8.2.2 ko:K19713 - - - - ko00000,ko01000 - - - Cytochrom_C,Cytochrome_CBB3 k59_126140_50 1283283.ATXA01000003_gene1546 5.67e-13 80.1 COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria 201174|Actinobacteria P Sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_126140_51 1049564.TevJSym_aa02050 1.02e-86 263.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1J669@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG1214 Inactive homolog of metal-dependent proteases yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_617012_1 880073.Calab_2864 3.17e-10 63.5 COG0389@1|root,COG0389@2|Bacteria,2NP5S@2323|unclassified Bacteria 2|Bacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_453133_1 1499689.CCNN01000007_gene1162 2.43e-74 241.0 COG0687@1|root,COG1177@1|root,COG0687@2|Bacteria,COG1177@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia,36DK4@31979|Clostridiaceae 186801|Clostridia P Spermidine putrescine-binding periplasmic protein potD - - ko:K11069,ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1,SBP_bac_6,SBP_bac_8 k59_355849_1 1168034.FH5T_05040 2.48e-99 300.0 COG1078@1|root,COG1078@2|Bacteria,4NE1T@976|Bacteroidetes,2FMCR@200643|Bacteroidia 976|Bacteroidetes S HD domain protein - - - ko:K06885 - - - - ko00000 - - - HD k59_975404_1 156578.ATW7_12298 1.93e-55 201.0 COG1506@1|root,COG1506@2|Bacteria,1MWFI@1224|Proteobacteria,1RPJD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - DPPIV_N,Peptidase_S9 k59_453135_1 1168034.FH5T_12215 6.14e-128 371.0 COG0404@1|root,COG0404@2|Bacteria,4NF7S@976|Bacteroidetes,2FPDM@200643|Bacteroidia 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_943725_1 1168034.FH5T_17710 4.73e-80 260.0 COG0683@1|root,COG1388@1|root,COG0683@2|Bacteria,COG1388@2|Bacteria,4NG96@976|Bacteroidetes,2FNR1@200643|Bacteroidia 976|Bacteroidetes M LysM domain protein lysM - - - - - - - - - - - ANF_receptor,LysM,Peripla_BP_6 k59_355850_1 1049564.TevJSym_al00200 2.39e-130 387.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_649482_1 1449076.JOOE01000004_gene3 1.59e-20 95.5 COG1357@1|root,COG2931@1|root,COG3210@1|root,COG1357@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2K78I@204457|Sphingomonadales 204457|Sphingomonadales Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind,VCBS k59_552266_1 394221.Mmar10_0469 9.23e-46 164.0 COG0520@1|root,COG0520@2|Bacteria,1N124@1224|Proteobacteria,2TZXB@28211|Alphaproteobacteria,43ZHD@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_224882_1 1049564.TevJSym_ao00280 2.42e-102 327.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1224|Proteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_126143_1 517418.Ctha_0554 1.49e-25 99.4 COG1993@1|root,COG1993@2|Bacteria,1FE97@1090|Chlorobi 1090|Chlorobi S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 k59_256555_1 1196029.ALIM01000022_gene978 4.5e-190 533.0 COG0673@1|root,COG0673@2|Bacteria,1TR8S@1239|Firmicutes,4HBHI@91061|Bacilli,1ZDU7@1386|Bacillus 91061|Bacilli S Oxidoreductase - - 1.1.1.371 ko:K16044 ko00562,ko01120,map00562,map01120 - R09954 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_288025_1 765913.ThidrDRAFT_2128 1.96e-82 257.0 COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,1RRTC@1236|Gammaproteobacteria,1WWHR@135613|Chromatiales 135613|Chromatiales I Domain of unknown function (DUF389) - - - - - - - - - - - - DUF389 k59_288025_2 1286106.MPL1_02968 9.27e-14 67.4 COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,1SCD4@1236|Gammaproteobacteria,461DH@72273|Thiotrichales 72273|Thiotrichales S Transglycosylase associated protein - - - - - - - - - - - - Transgly_assoc k59_714361_1 391603.FBALC1_16287 6.2e-37 141.0 2CESB@1|root,2Z8UZ@2|Bacteria,4NJSJ@976|Bacteroidetes,1I15D@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DUF481 k59_552270_1 91464.S7335_1425 2.42e-15 79.3 COG1912@1|root,COG1912@2|Bacteria,1G1B1@1117|Cyanobacteria,1GYAI@1129|Synechococcus 1117|Cyanobacteria S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_388533_1 1548153.LR59_10805 2.12e-77 253.0 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42M62@68525|delta/epsilon subdivisions,2YMKY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Capsular polysaccharide ABC transporter, periplasmic polysaccharide-binding protein kpsD - - - - - - - - - - - Poly_export,SLBB k59_192611_1 37659.JNLN01000001_gene1392 6.22e-12 68.6 COG4461@1|root,COG4461@2|Bacteria,1VDVF@1239|Firmicutes,24N0M@186801|Clostridia,36KF8@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF4163) - - - - - - - - - - - - DUF3298,DUF4163 k59_192611_2 869213.JCM21142_72957 7.25e-46 154.0 2A42S@1|root,30SMP@2|Bacteria,4P40W@976|Bacteroidetes 976|Bacteroidetes S Nickel-containing superoxide dismutase - - - - - - - - - - - - Sod_Ni k59_192611_4 1216932.CM240_3261 8.82e-38 145.0 COG4928@1|root,COG4928@2|Bacteria,1V38I@1239|Firmicutes,24H2Q@186801|Clostridia,36JNG@31979|Clostridiaceae 186801|Clostridia S KAP family P-loop domain - - - - - - - - - - - - KAP_NTPase k59_844416_1 983917.RGE_35750 2.46e-210 588.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VK03@28216|Betaproteobacteria,1KJYT@119065|unclassified Burkholderiales 28216|Betaproteobacteria C TIGRFAM hydrogenase (NiFe) small subunit (hydA) hoxK GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_844416_2 648757.Rvan_0965 2.7e-65 214.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria,3N88J@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hupL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_355864_2 1003200.AXXA_09023 1.1e-62 199.0 2DF54@1|root,32U4N@2|Bacteria,1NMP3@1224|Proteobacteria 1224|Proteobacteria S Bacterial PH domain - - - - - - - - - - - - SHOCT,bPH_3 k59_126153_1 1537917.JU82_03810 4.82e-106 325.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2YMVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_288028_1 1120953.AUBH01000005_gene2427 1.39e-100 320.0 COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria,46979@72275|Alteromonadaceae 1236|Gammaproteobacteria G Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_256560_1 743719.PaelaDRAFT_5096 3.37e-47 174.0 COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,4HAS9@91061|Bacilli,26UAJ@186822|Paenibacillaceae 91061|Bacilli J GTP-binding protein tet3 - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_256560_2 1124780.ANNU01000023_gene3220 6.17e-32 131.0 COG0111@1|root,COG0560@1|root,COG0111@2|Bacteria,COG0560@2|Bacteria,4NDVN@976|Bacteroidetes,47MQ2@768503|Cytophagia 976|Bacteroidetes EH PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,HAD k59_457746_2 572544.Ilyop_1564 3.42e-116 340.0 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat yfcA - - ko:K07090 - - - - ko00000 - - - TauE k59_457746_3 572544.Ilyop_0970 9.6e-70 213.0 COG0824@1|root,COG0824@2|Bacteria,37A9H@32066|Fusobacteria 32066|Fusobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 k59_294292_1 675812.VHA_000705 5.26e-121 365.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XSX1@135623|Vibrionales 135623|Vibrionales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0003674,GO:0003824,GO:0004802,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016740,GO:0016744,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_784629_1 1168034.FH5T_12580 1.44e-59 202.0 COG2067@1|root,COG2067@2|Bacteria,4NKM1@976|Bacteroidetes,2FPD4@200643|Bacteroidia 976|Bacteroidetes I Psort location OuterMembrane, score - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - OMP_b-brl k59_130847_1 391615.ABSJ01000046_gene2112 1.9e-15 75.9 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria 1236|Gammaproteobacteria G TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_130847_2 1121405.dsmv_0648 1.13e-20 89.0 COG3090@1|root,COG3090@2|Bacteria,1MZNX@1224|Proteobacteria,42TZJ@68525|delta/epsilon subdivisions,2WQB8@28221|Deltaproteobacteria,2MKJH@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - - - - - - - - - - DctQ k59_130849_1 1122605.KB893637_gene3348 1.13e-49 179.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1IV3D@117747|Sphingobacteriia 976|Bacteroidetes H TIGRFAM TonB-dependent outer membrane receptor, SusC RagA subfamily, signature region - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_882744_1 96561.Dole_0801 7.08e-48 159.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NZS@68525|delta/epsilon subdivisions,2WINI@28221|Deltaproteobacteria,2MI5U@213118|Desulfobacterales 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_882744_2 1121405.dsmv_1712 6.71e-26 97.4 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42UFU@68525|delta/epsilon subdivisions,2WR59@28221|Deltaproteobacteria,2MKI0@213118|Desulfobacterales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_32791_1 1144342.PMI40_01583 9.59e-06 47.4 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,472AR@75682|Oxalobacteraceae 28216|Betaproteobacteria C IG-like fold at C-terminal of FixG, putative oxidoreductase ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_32791_2 1007105.PT7_1439 4.03e-10 58.9 2EFX9@1|root,339PI@2|Bacteria,1NI0D@1224|Proteobacteria,2VU0U@28216|Betaproteobacteria,3T4SX@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_32791_3 1144342.PMI40_01582 1.6e-12 67.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,4726F@75682|Oxalobacteraceae 28216|Betaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_294299_2 760568.Desku_2648 7.91e-08 55.8 COG0589@1|root,COG0589@2|Bacteria,1V1UN@1239|Firmicutes,24HEQ@186801|Clostridia 186801|Clostridia T PFAM UspA - - - - - - - - - - - - Usp k59_294299_3 306537.jk1918 3.49e-18 77.4 COG1773@1|root,COG1773@2|Bacteria,2HN5Z@201174|Actinobacteria,22PI0@1653|Corynebacteriaceae 201174|Actinobacteria C Rubredoxin rubA - - - - - - - - - - - Rubredoxin k59_196242_1 326298.Suden_1033 8.76e-14 70.1 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,42PAW@68525|delta/epsilon subdivisions,2YNM3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_65458_1 1132442.KB889752_gene451 0.0 1032.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,4HCXR@91061|Bacilli,1ZRHZ@1386|Bacillus 91061|Bacilli G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_817343_1 1150621.SMUL_1956 2.14e-103 311.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2YMDM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H dihydropteroate synthase folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_65459_1 983917.RGE_43500 1.76e-18 89.4 28KUM@1|root,2ZABC@2|Bacteria,1R683@1224|Proteobacteria,2VPU1@28216|Betaproteobacteria,1KKMU@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function (DUF2868) - - - - - - - - - - - - DUF2868,DUF3482 k59_65461_1 985054.JQEZ01000001_gene2642 9.86e-12 65.5 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,4NB3J@97050|Ruegeria 28211|Alphaproteobacteria V ABC transporter, permease ATP-binding protein msbA2 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_65461_2 290318.Cvib_0114 4.96e-09 57.8 COG2801@1|root,COG4928@1|root,COG2801@2|Bacteria,COG4928@2|Bacteria 2|Bacteria G KAP family P-loop domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,KAP_NTPase,rve,rve_3 k59_555849_1 1111131.HMPREF1255_0755 5.99e-36 135.0 COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4DU0U@85009|Propionibacteriales 201174|Actinobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster preT - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3 k59_555849_2 1236542.BALM01000006_gene3265 3.67e-78 259.0 COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,2QA4T@267890|Shewanellaceae 1236|Gammaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_751985_1 572544.Ilyop_1882 4.83e-138 395.0 COG0834@1|root,COG0834@2|Bacteria,37A23@32066|Fusobacteria 32066|Fusobacteria ET Bacterial periplasmic substrate-binding proteins - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_751985_2 572544.Ilyop_1880 1.13e-68 231.0 COG0210@1|root,COG0210@2|Bacteria 2|Bacteria L ATP-dependent DNA helicase activity - - 3.1.11.5,3.6.4.12 ko:K03582,ko:K03657 ko03420,ko03430,ko03440,map03420,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1013497_1 1089547.KB913013_gene3581 2.44e-74 254.0 COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,47MPU@768503|Cytophagia 976|Bacteroidetes G glycoside hydrolase family 2 sugar binding - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_106,Glyco_hydro_2_N k59_228960_1 396588.Tgr7_2800 8e-49 169.0 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,1X2PU@135613|Chromatiales 135613|Chromatiales EGP Drug resistance transporter Bcr CflA subfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_1013499_1 1300345.LF41_2649 4.54e-23 106.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales 135614|Xanthomonadales T Adenylate cyclase - - - - - - - - - - - - - k59_107_2 582899.Hden_0687 1.07e-16 78.6 COG0518@1|root,COG0518@2|Bacteria,1MYXC@1224|Proteobacteria,2UBE9@28211|Alphaproteobacteria 28211|Alphaproteobacteria F GMP synthase (glutamine-hydrolyzing) activity - - - - - - - - - - - - - k59_555853_1 929558.SMGD1_0909 1.79e-73 229.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,42NM9@68525|delta/epsilon subdivisions,2YNQC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_555853_2 1565314.OA34_00400 9.75e-31 119.0 2DBJK@1|root,2Z9MI@2|Bacteria,1QW5X@1224|Proteobacteria,43DAY@68525|delta/epsilon subdivisions,2YTI0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_948119_1 1250006.JHZZ01000001_gene808 3.44e-45 158.0 COG3547@1|root,COG3547@2|Bacteria,4NKDC@976|Bacteroidetes,1HXB1@117743|Flavobacteriia,3VWVC@52959|Polaribacter 976|Bacteroidetes L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_65467_1 1168034.FH5T_06150 4.8e-08 53.5 COG0157@1|root,COG0157@2|Bacteria,4NDXF@976|Bacteroidetes,2FMJM@200643|Bacteroidia 976|Bacteroidetes H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_65467_2 1168034.FH5T_06155 6.3e-131 387.0 COG0029@1|root,COG0029@2|Bacteria,4NGUE@976|Bacteroidetes,2FNMT@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_653927_1 367737.Abu_2169 1.45e-229 640.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2YMSV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E o-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_653927_2 1355374.JARU01000011_gene2229 2.85e-65 215.0 28JKB@1|root,2Z9D6@2|Bacteria,1NVYW@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_653927_3 367737.Abu_1528 1.11e-21 103.0 2DB7X@1|root,2Z7P2@2|Bacteria,1NWZ6@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_719326_1 316067.Geob_3691 1.06e-14 76.3 COG3920@1|root,COG4191@1|root,COG3920@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,43U1A@69541|Desulfuromonadales 28221|Deltaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_32822_1 1215092.PA6_001_00380 1.11e-128 378.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1YE8T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275 DHQ_synthase k59_653931_2 1165841.SULAR_09334 9.55e-85 254.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2YN1G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_490481_1 1232437.KL661963_gene3414 2.65e-162 464.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,42R7H@68525|delta/epsilon subdivisions,2WMU0@28221|Deltaproteobacteria,2MK2C@213118|Desulfobacterales 28221|Deltaproteobacteria S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_523169_1 1347392.CCEZ01000013_gene2626 1.12e-39 144.0 COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,36F3G@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase - - - ko:K07137 - - - - ko00000 - - - FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4 k59_686630_1 314278.NB231_03827 1.79e-17 78.6 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, E subunit - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_686630_2 713586.KB900536_gene3046 3.08e-205 574.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_719329_1 1168034.FH5T_04695 1.88e-16 75.5 2E4AG@1|root,32Z66@2|Bacteria,4NYIR@976|Bacteroidetes 976|Bacteroidetes S Domain of unknown function (DUF4783) - - - - - - - - - - - - DUF4783 k59_719329_2 1168034.FH5T_04690 1.17e-76 232.0 COG1576@1|root,COG1576@2|Bacteria,4NMFP@976|Bacteroidetes,2FN6G@200643|Bacteroidia 976|Bacteroidetes J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_817369_1 795797.C497_05357 1.67e-31 125.0 COG0733@1|root,arCOG04466@2157|Archaea,2XTG1@28890|Euryarchaeota,23SDV@183963|Halobacteria 183963|Halobacteria P COG0733 Na -dependent transporters of the SNF family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_948132_1 929558.SMGD1_0411 3.7e-12 65.9 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,42PMY@68525|delta/epsilon subdivisions,2YMBR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_948132_2 929558.SMGD1_2123 4.07e-95 287.0 COG0598@1|root,COG0598@2|Bacteria,1NWUN@1224|Proteobacteria,42S8K@68525|delta/epsilon subdivisions,2YPDR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P CorA-like Mg2 transporter protein - - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_98231_1 472759.Nhal_2510 5.34e-93 283.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales 135613|Chromatiales C PFAM Alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_784678_1 1121459.AQXE01000004_gene1748 1.11e-36 136.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2MB0W@213115|Desulfovibrionales 28221|Deltaproteobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis yggS - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_32841_1 396588.Tgr7_0560 7.44e-74 236.0 COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1WWXK@135613|Chromatiales 135613|Chromatiales S glutamate--cysteine ligase - - - - - - - - - - - - GCS2 k59_98233_1 492774.JQMB01000002_gene1264 1.55e-87 266.0 COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2TUZX@28211|Alphaproteobacteria,4BAR3@82115|Rhizobiaceae 28211|Alphaproteobacteria E Ornithine cyclodeaminase/mu-crystallin family - - 1.4.1.1,4.3.1.12 ko:K01750,ko:K19244 ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230 - R00396,R00671 RC00008,RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_392450_1 1177181.T9A_02169 2.49e-65 209.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1XI8U@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_948140_1 1121937.AUHJ01000014_gene2678 3.46e-38 148.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T239@1236|Gammaproteobacteria,46DDX@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_653952_1 1168034.FH5T_01510 1.03e-110 350.0 COG0577@1|root,COG0577@2|Bacteria,4NZYZ@976|Bacteroidetes,2FWFC@200643|Bacteroidia 976|Bacteroidetes V FtsX-like permease family - - - - - - - - - - - - FtsX k59_457810_1 983545.Glaag_0680 8.86e-189 542.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,4647I@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,STAS_2,Sulfate_transp k59_457810_2 642492.Clole_1080 8.03e-69 217.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia 186801|Clostridia C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_555890_1 1121405.dsmv_1764 1.43e-68 226.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2MIQB@213118|Desulfobacterales 28221|Deltaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_523192_1 1295642.H839_06094 1.15e-65 216.0 COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,4HA0U@91061|Bacilli,1WE9V@129337|Geobacillus 91061|Bacilli G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 k59_817386_1 1408473.JHXO01000006_gene1156 2.1e-22 101.0 COG0115@1|root,COG0115@2|Bacteria,4NG0G@976|Bacteroidetes,2FZI0@200643|Bacteroidia 976|Bacteroidetes EH Amino-transferase class IV ilvE - 2.6.1.42,4.1.3.38 ko:K00826,ko:K02619 ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R05553,R10991 RC00006,RC00036,RC01843,RC02148 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_752037_1 1472716.KBK24_0112915 7.06e-110 326.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,1K0CZ@119060|Burkholderiaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_163628_2 1196083.SALWKB12_0367 1.48e-27 111.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2VIFH@28216|Betaproteobacteria,2KQZK@206351|Neisseriales 206351|Neisseriales H Psort location Cytoplasmic, score 8.96 - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_98246_1 1392502.JNIO01000008_gene1954 5.25e-08 59.7 COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,4H30U@909932|Negativicutes 909932|Negativicutes L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_915459_1 1168034.FH5T_01490 4.53e-80 257.0 COG1208@1|root,COG1208@2|Bacteria,4NGYR@976|Bacteroidetes,2FMJ4@200643|Bacteroidia 976|Bacteroidetes JM Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF4954 k59_948148_1 1125863.JAFN01000001_gene1857 6.63e-84 266.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_65508_1 502025.Hoch_2313 1.44e-41 156.0 COG3568@1|root,COG3568@2|Bacteria,1RGY4@1224|Proteobacteria 1224|Proteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_784695_1 977880.RALTA_A0210 6.72e-34 125.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2VHDA@28216|Betaproteobacteria,1K016@119060|Burkholderiaceae 28216|Betaproteobacteria P cation diffusion facilitator family transporter czcD2 - - - - - - - - - - - Cation_efflux k59_163640_1 1323663.AROI01000009_gene3479 6.56e-51 180.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RYP9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_229026_1 1123376.AUIU01000011_gene818 2.72e-79 252.0 COG3604@1|root,COG3604@2|Bacteria,3J0W9@40117|Nitrospirae 40117|Nitrospirae KT GAF domain - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF_2,HTH_8,Sigma54_activat k59_163642_1 1163617.SCD_n00409 6.95e-34 123.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJBY@28216|Betaproteobacteria 28216|Betaproteobacteria V abc transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_163642_2 472759.Nhal_3356 6.03e-45 157.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXP0@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_850125_1 270374.MELB17_15017 5.02e-118 360.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,464M6@72275|Alteromonadaceae 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_686671_2 414684.RC1_0538 1.13e-15 79.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,2VEZT@28211|Alphaproteobacteria,2JR2N@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3 k59_457840_1 1201293.AKXQ01000035_gene1075 1.46e-58 205.0 COG0236@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1R89Z@1224|Proteobacteria,1SMTI@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q polyketide synthase pfaA - - ko:K21783 ko00333,ko01130,map00333,map01130 M00837,M00838 R11665 - ko00000,ko00001,ko00002,ko01000 - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,PS-DH,ketoacyl-synt k59_163647_1 2340.JV46_21860 9e-52 187.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1J4ZR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_156_1 261292.Nit79A3_2954 1.32e-102 311.0 COG1376@1|root,COG1388@1|root,COG1376@2|Bacteria,COG1388@2|Bacteria,1MVYT@1224|Proteobacteria,2VMTY@28216|Betaproteobacteria,373X8@32003|Nitrosomonadales 28216|Betaproteobacteria M SMART Peptidoglycan-binding Lysin subgroup - - - ko:K16291 - - - - ko00000,ko01002,ko01011 - - - LysM,YkuD k59_130928_1 1121396.KB893090_gene242 1.16e-150 428.0 COG1092@1|root,COG1092@2|Bacteria,1QW1V@1224|Proteobacteria,42Q3P@68525|delta/epsilon subdivisions,2WJXM@28221|Deltaproteobacteria,2MHVR@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the methyltransferase superfamily - - 2.1.1.173,2.1.1.191,2.1.1.264 ko:K06969,ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_359785_3 2340.JV46_19500 4.9e-40 134.0 2FG0M@1|root,347XB@2|Bacteria,1P191@1224|Proteobacteria,1SSBB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1488) - - - - - - - - - - - - DUF1488 k59_425147_1 335543.Sfum_3622 1.82e-64 204.0 COG0655@1|root,COG0655@2|Bacteria,1RD5X@1224|Proteobacteria,42T3S@68525|delta/epsilon subdivisions,2WN9W@28221|Deltaproteobacteria,2MQMP@213462|Syntrophobacterales 28221|Deltaproteobacteria S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_98272_2 1167006.UWK_01954 5.69e-08 54.7 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,43BRR@68525|delta/epsilon subdivisions,2WMB1@28221|Deltaproteobacteria,2MI5N@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_458344_2 1211777.BN77_p30027 2.49e-16 73.9 COG4423@1|root,COG4423@2|Bacteria,1NDG1@1224|Proteobacteria,2UDZV@28211|Alphaproteobacteria,4BG1B@82115|Rhizobiaceae 28211|Alphaproteobacteria S Rv0623-like transcription factor - - - ko:K19687 - - - - ko00000,ko02048 - - - PSK_trans_fac k59_458344_3 555779.Dthio_PD1992 5.77e-32 115.0 COG3742@1|root,COG3742@2|Bacteria,1Q9V8@1224|Proteobacteria,432KI@68525|delta/epsilon subdivisions,2WXAS@28221|Deltaproteobacteria,2MFTK@213115|Desulfovibrionales 28221|Deltaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_719827_1 292.DM42_2069 2.27e-68 219.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VH9Y@28216|Betaproteobacteria,1K0HZ@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_294890_1 1537917.JU82_11030 3.09e-60 197.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2YMJW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N k59_915999_1 864051.BurJ1DRAFT_0974 2.79e-57 199.0 28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,2VPEJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_360316_1 469617.FUAG_01616 5.8e-56 193.0 COG2148@1|root,COG2148@2|Bacteria,37984@32066|Fusobacteria 32066|Fusobacteria M Bacterial sugar transferase - - 2.7.8.6 ko:K00996 - - - - ko00000,ko01000,ko01005 - - - Bac_transf,CoA_binding_3 k59_236989_1 749222.Nitsa_0818 2.69e-47 157.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2YPDX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GatB Yqey family protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_139692_1 1121447.JONL01000007_gene1175 4.55e-18 89.7 COG0715@1|root,COG5000@1|root,COG0715@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_139692_2 1121396.KB892913_gene161 1.01e-49 173.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJKZ@28221|Deltaproteobacteria,2MI48@213118|Desulfobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_73903_1 762903.Pedsa_3706 2.81e-86 286.0 COG4206@1|root,COG4206@2|Bacteria,4NHTX@976|Bacteroidetes,1IRJA@117747|Sphingobacteriia 976|Bacteroidetes H TIGRFAM TonB-dependent outer membrane receptor, SusC RagA subfamily, signature region - - - - - - - - - - - - Plug,TonB_dep_Rec k59_629609_2 1184607.AUCHE_05_06090 1.35e-92 291.0 COG1882@1|root,COG1882@2|Bacteria,2GTTT@201174|Actinobacteria,4F7MD@85018|Dermatophilaceae 201174|Actinobacteria C Glycine radical pflB - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_988963_2 360107.CHAB381_0599 6.32e-28 120.0 2AJW1@1|root,31AIU@2|Bacteria,1Q5R1@1224|Proteobacteria,431NE@68525|delta/epsilon subdivisions,2YS95@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_368123_1 1293054.HSACCH_00209 7.53e-76 234.0 28HGK@1|root,2Z7SE@2|Bacteria,1UP9Q@1239|Firmicutes 1239|Firmicutes S Malonate/sodium symporter MadM subunit madM - - - - - - - - - - - MadM k59_139699_1 1247649.D560_0787 9.63e-64 216.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VPT3@28216|Betaproteobacteria,3T8RH@506|Alcaligenaceae 28216|Betaproteobacteria V ABC transporter transmembrane region sunT - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran k59_335895_2 247634.GPB2148_1219 1.31e-05 47.4 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S60F@1236|Gammaproteobacteria,1J6M3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S aspartyl protease orf - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_1021494_1 1049564.TevJSym_bo00190 1.26e-42 157.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT,EB_dh k59_1021494_2 1304883.KI912532_gene3212 1.93e-05 45.4 COG3794@1|root,COG3794@2|Bacteria,1N889@1224|Proteobacteria,2WFFY@28216|Betaproteobacteria,2KZ72@206389|Rhodocyclales 206389|Rhodocyclales C blue (type 1) copper - - - - - - - - - - - - Copper-bind k59_301683_1 452637.Oter_2603 5.9e-35 137.0 COG2864@1|root,COG2864@2|Bacteria 2|Bacteria C formate dehydrogenase cbcY - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese k59_663118_1 1168034.FH5T_06675 3.11e-94 305.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,2FMI7@200643|Bacteroidia 976|Bacteroidetes E 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_825874_1 563040.Saut_2023 3.47e-29 111.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,42YWZ@68525|delta/epsilon subdivisions,2YRHN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_890843_1 563040.Saut_0564 2.98e-63 205.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2YMQE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_400621_1 572544.Ilyop_0603 2.48e-123 364.0 COG0168@1|root,COG0168@2|Bacteria,37893@32066|Fusobacteria 32066|Fusobacteria P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_759708_1 1485545.JQLW01000006_gene397 3.02e-149 440.0 COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria 1224|Proteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_759708_2 631362.Thi970DRAFT_03498 2.43e-63 213.0 COG2433@1|root,COG2433@2|Bacteria,1N0ZS@1224|Proteobacteria,1S7FF@1236|Gammaproteobacteria,1WYCM@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_759708_3 1123228.AUIH01000007_gene2531 5.51e-61 195.0 COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,1RPZ6@1236|Gammaproteobacteria,1XJ6Q@135619|Oceanospirillales 135619|Oceanospirillales D Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions slmA - - ko:K05501 - - - - ko00000,ko03000,ko03036 - - - TetR_N k59_759708_4 2340.JV46_16840 1.49e-169 478.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1J5E4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0033554,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.7.2.8 ko:K00930,ko:K22478 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00259,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2508,iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iUTI89_1310.UTI89_C4550,iY75_1357.Y75_RS17255 AA_kinase,NAT k59_759708_5 472759.Nhal_3802 1.01e-223 658.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales 135613|Chromatiales G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_759708_6 71421.HI_0954 6.48e-78 234.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,1Y8DY@135625|Pasteurellales 135625|Pasteurellales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_759708_7 1049564.TevJSym_am00060 6.64e-169 485.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1J4KE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_759708_8 998674.ATTE01000001_gene1819 6.7e-106 311.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,460D0@72273|Thiotrichales 72273|Thiotrichales E Belongs to the UPF0758 family - - - ko:K03630 - - - - ko00000 - - - RadC k59_759708_9 870187.Thini_1225 3.7e-43 141.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,460X2@72273|Thiotrichales 72273|Thiotrichales J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_759708_10 2340.JV46_25820 1.09e-24 92.8 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1J6XH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_759708_11 1049564.TevJSym_by00040 5.87e-67 209.0 COG2888@1|root,COG2888@2|Bacteria,1PBSM@1224|Proteobacteria,1SWH0@1236|Gammaproteobacteria,1JBN5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Zinc-ribbon containing domain - - - - - - - - - - - - DUF1451 k59_759708_12 1049564.TevJSym_by00030 0.0 1212.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1J4T4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_759708_13 105559.Nwat_0452 1.26e-21 93.2 COG2980@1|root,COG2980@2|Bacteria,1NGPX@1224|Proteobacteria,1SGKQ@1236|Gammaproteobacteria,1WY80@135613|Chromatiales 135613|Chromatiales M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_759708_14 1182590.BN5_03464 1.06e-103 316.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1YICB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Processivity clamp loader gamma complex DNA pol III C-term holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_759708_15 1049564.TevJSym_bg00200 1.91e-237 660.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1J4G6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iYL1228.KPN_00280 Aldedh k59_759708_16 572477.Alvin_2147 2.38e-77 238.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales 135613|Chromatiales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_759708_17 1049564.TevJSym_bg00170 2.31e-51 165.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1J6PI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_759708_18 1348635.BBJY01000012_gene1154 3.16e-57 182.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1XSIT@135623|Vibrionales 135623|Vibrionales J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_759708_19 287.DR97_1657 5.16e-64 203.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1YEU5@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria D Maf-like protein yhdE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf k59_759708_20 1049564.TevJSym_ak00680 2.62e-256 714.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1530 Ribonucleases G and E rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_759708_21 1198232.CYCME_0807 1.72e-166 538.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,460QS@72273|Thiotrichales 72273|Thiotrichales S TIGRFAM TIGR02099 family protein - - - - - - - - - - - - AsmA_2,DUF3971 k59_759708_22 765913.ThidrDRAFT_2321 3.62e-120 352.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales 135613|Chromatiales S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_759708_23 519989.ECTPHS_02976 1.6e-249 696.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_759708_24 572477.Alvin_2519 9.94e-208 587.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_759708_25 1537915.JU57_01955 1.43e-73 232.0 COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,42UNC@68525|delta/epsilon subdivisions,2YQNU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_759708_29 547163.BN979_01114 3.97e-88 268.0 COG1656@1|root,COG1656@2|Bacteria,2GMQR@201174|Actinobacteria,23528@1762|Mycobacteriaceae 201174|Actinobacteria S Mut7-C ubiquitin - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_5650_1 1134912.AJTV01000020_gene3072 6.4e-14 72.4 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2TR90@28211|Alphaproteobacteria,36YE8@31993|Methylocystaceae 28211|Alphaproteobacteria S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_5650_2 1172190.M947_02100 7.62e-157 456.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2YNSP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL k59_956109_1 1168034.FH5T_16780 8.23e-115 344.0 COG1109@1|root,COG1109@2|Bacteria,4NFU7@976|Bacteroidetes,2FM0A@200643|Bacteroidia 976|Bacteroidetes G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II pgcA - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_172659_1 713587.THITH_17480 1.01e-42 157.0 COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RQRW@1236|Gammaproteobacteria,1WWNC@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_400629_1 709032.Sulku_1256 1.18e-103 311.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,42MHN@68525|delta/epsilon subdivisions,2YMYK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Involved in arsenical resistance. Thought to form the channel of an arsenite pump arsB - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - ArsB k59_368713_1 1353537.TP2_08085 7.76e-78 249.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,2XKQB@285107|Thioclava 28211|Alphaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_368713_2 1415756.JQMY01000001_gene3242 1.67e-13 68.2 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,2PCQE@252301|Oceanicola 28211|Alphaproteobacteria F Adenylate kinase, active site lid adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_727489_1 1049564.TevJSym_ab01910 6.72e-76 244.0 COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter ygaD - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_630233_1 1165841.SULAR_07013 4.96e-83 253.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,42SQE@68525|delta/epsilon subdivisions,2YPHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0003674,GO:0003824,GO:0004141,GO:0016874,GO:0016879,GO:0016882 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_791667_1 572480.Arnit_1434 3.85e-25 94.4 COG3655@1|root,COG3655@2|Bacteria,1N6VH@1224|Proteobacteria,42WD9@68525|delta/epsilon subdivisions 1224|Proteobacteria K transcriptional regulator, XRE family BT2546 - - ko:K07727 - - - - ko00000,ko03000 - - - HTH_26 k59_791667_2 572480.Arnit_1433 7.96e-86 257.0 2BVXN@1|root,32S7Z@2|Bacteria,1R39Q@1224|Proteobacteria,42W95@68525|delta/epsilon subdivisions 1224|Proteobacteria S Protein of unknown function (DUF2975) - - - - - - - - - - - - DUF2975 k59_630235_2 1384056.N787_02385 1.35e-78 245.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales 135614|Xanthomonadales I Acyl-CoA dehydrogenase gcdH - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_663119_2 1249480.B649_07390 3.94e-100 358.0 COG2304@1|root,COG4932@1|root,COG5295@1|root,COG2304@2|Bacteria,COG4932@2|Bacteria,COG5295@2|Bacteria,1QU09@1224|Proteobacteria,43DI2@68525|delta/epsilon subdivisions 1224|Proteobacteria M von Willebrand factor (vWF) type A domain - - - - - - - - - - - - Calx-beta,HemolysinCabind,VWA_2 k59_302155_1 1165841.SULAR_03587 3.36e-117 363.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0474 Cation transport ATPase - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_532480_1 572544.Ilyop_0618 1.02e-107 324.0 COG0172@1|root,COG0172@2|Bacteria,378ZK@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_630245_1 1461580.CCAS010000021_gene2334 1.04e-31 129.0 COG1361@1|root,COG1470@1|root,COG2247@1|root,COG3209@1|root,COG3386@1|root,COG4733@1|root,COG5492@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,COG2247@2|Bacteria,COG3209@2|Bacteria,COG3386@2|Bacteria,COG4733@2|Bacteria,COG5492@2|Bacteria,1V0PN@1239|Firmicutes,4HWCI@91061|Bacilli,1ZFT8@1386|Bacillus 91061|Bacilli N COG3209 Rhs family protein - - - - - - - - - - - - Glug,Gram_pos_anchor k59_759744_1 13333.ERN02876 1.29e-113 342.0 28JJ8@1|root,2QRYE@2759|Eukaryota,37RH7@33090|Viridiplantae,3GCW8@35493|Streptophyta 35493|Streptophyta C PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin psaA - - ko:K02689 ko00195,ko01100,map00195,map01100 M00163 - - ko00000,ko00001,ko00002,ko00194 - - - PsaA_PsaB k59_466780_1 991905.SL003B_1196 5.69e-23 96.7 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,4BP8V@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_858156_1 338966.Ppro_2303 2.37e-30 126.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,43TCH@69541|Desulfuromonadales 28221|Deltaproteobacteria J TIGRFAM phenylalanyl-tRNA synthetase, beta subunit pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_695068_1 1122599.AUGR01000010_gene950 5.83e-46 157.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1XKC6@135619|Oceanospirillales 135619|Oceanospirillales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_466786_1 68199.JNZO01000050_gene1578 7.57e-07 52.8 COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_663138_1 207954.MED92_03797 6.6e-34 133.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XHFD@135619|Oceanospirillales 135619|Oceanospirillales P P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_663138_2 1033802.SSPSH_002855 4.56e-11 59.7 COG3197@1|root,COG3197@2|Bacteria 2|Bacteria P Cytochrome oxidase maturation protein ccoS - - - - - - - - - - - FixS k59_759756_1 105559.Nwat_1090 5.44e-114 360.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1022072_1 572544.Ilyop_0594 7.99e-44 151.0 COG4731@1|root,COG4731@2|Bacteria,37AQ5@32066|Fusobacteria 32066|Fusobacteria S Uncharacterized protein conserved in bacteria (DUF2147) - - - - - - - - - - - - DUF2147 k59_564887_1 709032.Sulku_2350 6.25e-116 345.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2YMGW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - iIT341.HP0144 COX1 k59_564887_2 1537917.JU82_02120 1.74e-21 89.4 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,42NZG@68525|delta/epsilon subdivisions,2YMBE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cytochrome c oxidase, cbb3-type, subunit II ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - iIT341.HP0145 FixO k59_858163_1 1304284.L21TH_2090 8.08e-69 225.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,248BZ@186801|Clostridia,36E93@31979|Clostridiaceae 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3,Peripla_BP_4 k59_825927_1 1120966.AUBU01000008_gene2398 1.25e-41 155.0 COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,4NEVN@976|Bacteroidetes,47MR3@768503|Cytophagia 976|Bacteroidetes T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_12,TPR_8 k59_336548_1 1121430.JMLG01000002_gene1324 2.36e-10 66.6 COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia,2611U@186807|Peptococcaceae 186801|Clostridia L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_40244_1 869213.JCM21142_93538 1.1e-144 431.0 COG3459@1|root,COG3459@2|Bacteria,4NIVN@976|Bacteroidetes,47MEX@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolase 36 superfamily, catalytic domain cepA - 2.4.1.20 ko:K00702 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000 - GT36 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_924654_1 1167006.UWK_01483 3.8e-72 226.0 COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RDM@68525|delta/epsilon subdivisions,2WMYM@28221|Deltaproteobacteria,2MJHP@213118|Desulfobacterales 28221|Deltaproteobacteria L Bacterial dnaA protein helix-turn-helix - - - ko:K07491 - - - - ko00000 - - - Bac_DnaA_C,Y1_Tnp k59_890893_1 395963.Bind_1450 1.82e-19 86.7 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,3NAX6@45404|Beijerinckiaceae 28211|Alphaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_890893_2 929558.SMGD1_1790 2.76e-121 351.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2YM9Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Enoyl- acyl-carrier-protein reductase NADH fabI GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_205114_1 1168034.FH5T_10050 2.92e-108 317.0 COG0345@1|root,COG0345@2|Bacteria,4NE6F@976|Bacteroidetes,2FMRG@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_630286_1 572544.Ilyop_1003 3.44e-121 370.0 COG0574@1|root,COG3605@1|root,COG0574@2|Bacteria,COG3605@2|Bacteria,378MB@32066|Fusobacteria 32066|Fusobacteria G Psort location Cytoplasmic, score 9.97 ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_732348_2 671143.DAMO_1309 5.27e-67 206.0 COG1943@1|root,COG1943@2|Bacteria,2NRRG@2323|unclassified Bacteria 2|Bacteria L Transposase IS200 like isplu5A - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_538287_1 765911.Thivi_3322 5.28e-119 366.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_342568_1 1168034.FH5T_12805 3.76e-100 310.0 COG0480@1|root,COG0480@2|Bacteria,4NE9X@976|Bacteroidetes,2FM1M@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_146247_1 323848.Nmul_A2699 3.84e-57 182.0 COG0221@1|root,COG0221@2|Bacteria,1RGCP@1224|Proteobacteria,2VRVG@28216|Betaproteobacteria,3747J@32003|Nitrosomonadales 28216|Betaproteobacteria C Inorganic pyrophosphatase - - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_669110_1 933262.AXAM01000026_gene3089 7.84e-41 150.0 COG1629@1|root,COG4771@2|Bacteria,1R1ZC@1224|Proteobacteria,43DCQ@68525|delta/epsilon subdivisions,2X8IR@28221|Deltaproteobacteria,2MPPA@213118|Desulfobacterales 2|Bacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_863578_1 631362.Thi970DRAFT_02048 9.75e-20 83.2 COG3153@1|root,COG3153@2|Bacteria,1RHPP@1224|Proteobacteria,1S7G1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S acetyltransferase VVA1529 - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,Acetyltransf_9 k59_146250_1 997884.HMPREF1068_01139 4.59e-123 362.0 COG2152@1|root,COG2152@2|Bacteria,4NGA2@976|Bacteroidetes,2FMJR@200643|Bacteroidia,4AKWA@815|Bacteroidaceae 976|Bacteroidetes G Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose - - 2.4.1.281 ko:K16212 - - R09943 RC00049 ko00000,ko01000 - - - Glyco_hydro_130 k59_146250_2 1121912.AUHD01000004_gene2045 8.44e-16 77.8 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1HWTC@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_570229_1 765912.Thimo_1968 2.22e-49 174.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales 135613|Chromatiales CI TIGRFAM Oxaloacetate decarboxylase, alpha subunit - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_506153_1 1121918.ARWE01000001_gene2528 9.3e-44 151.0 COG0583@1|root,COG0583@2|Bacteria,1MZX1@1224|Proteobacteria,42Q0Y@68525|delta/epsilon subdivisions,2WMJA@28221|Deltaproteobacteria 28221|Deltaproteobacteria K LysR substrate binding domain ilvY - - ko:K02521 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_863586_1 749222.Nitsa_0162 1.33e-114 348.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2YM9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase - - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 k59_930313_1 1249627.D779_3281 6.07e-10 61.2 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1WWM8@135613|Chromatiales 135613|Chromatiales IQ TIGRFAM acetoacetyl-CoA reductase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_669121_1 349521.HCH_02064 1.05e-41 152.0 28H52@1|root,2ZADT@2|Bacteria,1R8NH@1224|Proteobacteria,1RQUB@1236|Gammaproteobacteria,1XNVS@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_112462_1 1123073.KB899242_gene928 8.15e-24 97.1 COG1309@1|root,COG1309@2|Bacteria,1R52P@1224|Proteobacteria,1S6PU@1236|Gammaproteobacteria,1X3R7@135614|Xanthomonadales 135614|Xanthomonadales K Bacterial transcriptional repressor - - - - - - - - - - - - TetR,TetR_N k59_112462_2 1121013.P873_02335 4.21e-28 103.0 COG4281@1|root,COG4281@2|Bacteria,1MZPP@1224|Proteobacteria,1SF9T@1236|Gammaproteobacteria,1X7GR@135614|Xanthomonadales 135614|Xanthomonadales I Acyl CoA binding protein - - - - - - - - - - - - ACBP k59_374011_2 572544.Ilyop_0777 3.11e-84 253.0 COG0393@1|root,COG0393@2|Bacteria 2|Bacteria S Putative heavy-metal-binding - - - - - - - - - - - - YbjQ_1 k59_374011_4 586413.CCDL010000003_gene3233 1e-63 202.0 COG1896@1|root,COG1896@2|Bacteria,1TQ4N@1239|Firmicutes,4HGGZ@91061|Bacilli,23MHW@182709|Oceanobacillus 91061|Bacilli S HD domain - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_406264_1 1304885.AUEY01000011_gene1744 1.28e-32 123.0 COG1309@1|root,COG1309@2|Bacteria,1N6R3@1224|Proteobacteria,42N4M@68525|delta/epsilon subdivisions,2WQ5F@28221|Deltaproteobacteria,2MKF8@213118|Desulfobacterales 28221|Deltaproteobacteria K WHG domain - - - - - - - - - - - - TetR_N,WHG k59_146255_1 929506.CbC4_1381 2.29e-93 284.0 COG1237@1|root,COG1237@2|Bacteria,1UWI6@1239|Firmicutes,247K3@186801|Clostridia,36H5I@31979|Clostridiaceae 186801|Clostridia S hmm pf00753 - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_538311_1 1232437.KL662061_gene4181 4.66e-10 58.2 COG0745@1|root,COG0789@1|root,COG0745@2|Bacteria,COG0789@2|Bacteria,1RD9E@1224|Proteobacteria,42PTZ@68525|delta/epsilon subdivisions,2WKZI@28221|Deltaproteobacteria,2MHNV@213118|Desulfobacterales 28221|Deltaproteobacteria T Helix-turn-helix domain - - - - - - - - - - - - HTH_17,Response_reg k59_538311_2 439235.Dalk_2556 4.04e-38 136.0 COG0685@1|root,COG0685@2|Bacteria,1MWQ3@1224|Proteobacteria,42PKP@68525|delta/epsilon subdivisions,2WK0A@28221|Deltaproteobacteria,2MIZB@213118|Desulfobacterales 28221|Deltaproteobacteria E Methylenetetrahydrofolate reductase - - - - - - - - - - - - MTHFR k59_112466_1 247490.KSU1_B0709 6.34e-11 62.8 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - ko:K04767,ko:K07182 - - - - ko00000 - - - CBS k59_146259_1 998674.ATTE01000001_gene4114 1.53e-46 156.0 COG4665@1|root,COG4665@2|Bacteria,1QZG7@1224|Proteobacteria,1SZU1@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_146259_2 1122135.KB893157_gene166 3.44e-78 243.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS5C@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_342605_1 305700.B447_09153 1.15e-185 526.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,2KV1C@206389|Rhodocyclales 206389|Rhodocyclales H RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site rbcL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_603487_1 1500894.JQNN01000001_gene2305 2.2e-29 114.0 COG1215@1|root,COG1215@2|Bacteria,1QTWU@1224|Proteobacteria,2WGGD@28216|Betaproteobacteria,473WJ@75682|Oxalobacteraceae 28216|Betaproteobacteria M Glycosyl transferase family 2 arnC - 2.4.2.53 ko:K10012 ko00520,ko01503,map00520,map01503 M00721,M00761 R07661 RC00005,RC02954 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.2.1.8 GT2 - Glycos_transf_2 k59_603487_2 697282.Mettu_2528 1.02e-48 165.0 COG0726@1|root,COG0726@2|Bacteria,1N8Q4@1224|Proteobacteria,1RQ0R@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides arnD GO:0005575,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0042221,GO:0050896 - ko:K13014 ko00520,ko01503,map00520,map01503 M00721,M00761 R07662 RC00323,RC01575 ko00000,ko00001,ko00002,ko01000,ko01005 - - iB21_1397.B21_02141,iBWG_1329.BWG_2029,iEC042_1314.EC042_2499,iECBD_1354.ECBD_1403,iECB_1328.ECB_02182,iECDH10B_1368.ECDH10B_2416,iECDH1ME8569_1439.ECDH1ME8569_2192,iECD_1391.ECD_02182,iECO103_1326.ECO103_2722,iECO111_1330.ECO111_3006,iECO26_1355.ECO26_3246,iECUMN_1333.ECUMN_2597,iECW_1372.ECW_m2447,iEKO11_1354.EKO11_1508,iETEC_1333.ETEC_2390,iEcDH1_1363.EcDH1_1402,iEcHS_1320.EcHS_A2401,iEcolC_1368.EcolC_1393,iJO1366.b2256,iSFV_1184.SFV_2326,iSSON_1240.SSON_2317,iUMNK88_1353.UMNK88_2808,iWFL_1372.ECW_m2447,iY75_1357.Y75_RS11830 Polysacc_deac_1 k59_506181_1 1121405.dsmv_1370 1.36e-46 155.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MIE0@213118|Desulfobacterales 28221|Deltaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_506181_2 933262.AXAM01000021_gene466 5.64e-21 89.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,42T4F@68525|delta/epsilon subdivisions,2WP6B@28221|Deltaproteobacteria,2MJST@213118|Desulfobacterales 28221|Deltaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_45197_1 177437.HRM2_23930 4.48e-73 236.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,2MHPG@213118|Desulfobacterales 28221|Deltaproteobacteria M N-acetylmuramoyl-L-alanine amidase amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,TPR_6 k59_506188_1 1121918.ARWE01000001_gene2824 1.59e-52 178.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria 28221|Deltaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_112479_1 999541.bgla_2g27110 6.37e-53 193.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae 28216|Betaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - CHASE,EAL,GAF,GAF_2,GGDEF,HAMP,PAS_4,PAS_9,Response_reg k59_438447_1 1347392.CCEZ01000043_gene553 1.19e-29 117.0 COG2966@1|root,COG2966@2|Bacteria,1TSE8@1239|Firmicutes,24A25@186801|Clostridia,36EA1@31979|Clostridiaceae 186801|Clostridia S hmm pf06738 - - - - - - - - - - - - ThrE k59_538338_1 1537917.JU82_07400 3.5e-94 300.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2YMI5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P cation transport ATPase ccoI - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_930343_1 990073.ATHU01000001_gene888 2.63e-22 89.4 2AK1D@1|root,31AQZ@2|Bacteria,1Q5ZH@1224|Proteobacteria,42V6N@68525|delta/epsilon subdivisions,2YQ6B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_930343_2 1123326.JFBL01000016_gene2490 1.03e-48 161.0 COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,42T7P@68525|delta/epsilon subdivisions,2YPIP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions menG - - ko:K02553 - - - - ko00000,ko03019 - - - RraA-like k59_930343_3 387093.SUN_1085 1.73e-28 105.0 COG2185@1|root,COG2185@2|Bacteria,1RB2M@1224|Proteobacteria,42RER@68525|delta/epsilon subdivisions,2YP7X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Methylaspartate mutase mamA - 5.4.99.1 ko:K01846 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R00262 RC01221 ko00000,ko00001,ko00002,ko01000 - - - B12-binding k59_178887_1 592029.DDD_1152 2.22e-46 160.0 COG5295@1|root,COG5295@2|Bacteria,4NTMP@976|Bacteroidetes,1I4NQ@117743|Flavobacteriia 976|Bacteroidetes UW Hep Hag repeat protein - - - - - - - - - - - - Fib_succ_major k59_896824_1 1129794.C427_0212 6.05e-163 471.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,464XB@72275|Alteromonadaceae 1236|Gammaproteobacteria CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_506197_2 762966.HMPREF9439_02747 3.95e-43 146.0 COG3671@1|root,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria,4PR5N@995019|Sutterellaceae 28216|Betaproteobacteria S membrane - - - - - - - - - - - - - k59_1027024_1 598659.NAMH_0989 5.85e-113 337.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2YN4Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_930349_2 1236689.MMALV_12400 3.22e-26 108.0 COG1120@1|root,arCOG00198@2157|Archaea,2XV8E@28890|Euryarchaeota,3F3J4@33867|unclassified Euryarchaeota 28890|Euryarchaeota P ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_79573_1 1168034.FH5T_19575 1.15e-59 196.0 COG1760@1|root,COG1760@2|Bacteria,4NENR@976|Bacteroidetes,2FMVE@200643|Bacteroidia 976|Bacteroidetes E L-serine ammonia-lyase sdaA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_45219_1 706587.Desti_2952 1.33e-85 272.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2WINP@28221|Deltaproteobacteria,2MR0I@213462|Syntrophobacterales 28221|Deltaproteobacteria I PFAM Enoyl-CoA hydratase isomerase - - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_506214_1 754476.Q7A_1224 1.08e-58 187.0 2AEMZ@1|root,314HW@2|Bacteria,1RHE3@1224|Proteobacteria,1S7P7@1236|Gammaproteobacteria,462HH@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_274286_1 546275.FUSPEROL_00203 1.35e-25 105.0 COG0368@1|root,COG0368@2|Bacteria,379H2@32066|Fusobacteria 32066|Fusobacteria H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_274286_2 1321779.HMPREF1984_00895 2.55e-30 114.0 COG0406@1|root,COG0406@2|Bacteria,37939@32066|Fusobacteria 32066|Fusobacteria G Psort location Cytoplasmic, score 8.96 - - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_603531_1 1537917.JU82_00790 9.33e-69 216.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2YMR8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_274287_2 1069080.KB913028_gene71 0.000662 47.4 COG1560@1|root,COG1560@2|Bacteria,1U76T@1239|Firmicutes,4H2PH@909932|Negativicutes 909932|Negativicutes M Lipid A biosynthesis - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_471480_1 1165841.SULAR_09189 5.2e-91 276.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2YN15@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Glycosyl hydrolase family 3 - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Amidase_2,Glyco_hydro_3 k59_732426_1 1449076.JOOE01000001_gene1634 4.07e-20 93.6 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria,2K0FR@204457|Sphingomonadales 204457|Sphingomonadales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_930366_1 880072.Desac_0856 2.84e-72 224.0 COG1387@1|root,COG1387@2|Bacteria,1R9W5@1224|Proteobacteria,42QNF@68525|delta/epsilon subdivisions,2WMV0@28221|Deltaproteobacteria,2MRJE@213462|Syntrophobacterales 28221|Deltaproteobacteria E DNA polymerase alpha chain like domain - - - - - - - - - - - - PHP k59_796230_1 1348635.BBJY01000003_gene3748 0.000292 42.4 COG2706@1|root,COG2706@2|Bacteria,1MWGS@1224|Proteobacteria,1RNX2@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate - - 3.1.1.31 ko:K07404 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Lactonase k59_796230_2 90371.CY43_22480 5.59e-17 78.6 COG3381@1|root,COG3381@2|Bacteria,1RF2Y@1224|Proteobacteria,1S3Q9@1236|Gammaproteobacteria,3ZK3S@590|Salmonella 1236|Gammaproteobacteria S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_864540_1 1120968.AUBX01000014_gene2352 1.61e-21 92.0 COG3832@1|root,COG3832@2|Bacteria,4NQ4A@976|Bacteroidetes,47QHI@768503|Cytophagia 976|Bacteroidetes S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_212254_1 1537917.JU82_09425 2.14e-18 78.6 COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,42X24@68525|delta/epsilon subdivisions,2YPV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O hydrogenase assembly chaperone HypC hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_212254_2 1165841.SULAR_02898 1.08e-131 383.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2YMQU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the HypD family hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_472382_1 1449351.RISW2_02495 8.77e-42 145.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,4KMUV@93682|Roseivivax 28211|Alphaproteobacteria L transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_897782_1 1168034.FH5T_19475 1.52e-20 84.3 COG3832@1|root,COG3832@2|Bacteria,4PKNU@976|Bacteroidetes,2FUD3@200643|Bacteroidia 976|Bacteroidetes S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_897782_2 1168034.FH5T_19480 4.66e-72 236.0 COG3137@1|root,COG3137@2|Bacteria,4NRXD@976|Bacteroidetes,2FNZ5@200643|Bacteroidia 976|Bacteroidetes M Protein of unknown function (DUF3078) - - - - - - - - - - - - DUF3078 k59_439398_2 1537917.JU82_05320 2.55e-51 177.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2YN1V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_864544_1 563040.Saut_1758 2.56e-19 79.7 COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42VEW@68525|delta/epsilon subdivisions,2YQ7J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S RNA-binding protein - - - ko:K06960 - - - - ko00000 - - - KH_4 k59_864544_2 273121.WS0548 1.35e-35 122.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,42V30@68525|delta/epsilon subdivisions,2YPWV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_407244_2 700598.Niako_0476 4.22e-05 49.3 COG5412@1|root,COG5412@2|Bacteria,4NJXH@976|Bacteroidetes,1IX5R@117747|Sphingobacteriia 976|Bacteroidetes M Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157,Endonuclea_NS_2 k59_243851_1 1304885.AUEY01000004_gene952 2.44e-27 108.0 COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,2MI36@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM oxidoreductase FAD NAD(P)-binding domain protein nfnB - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_439408_1 768671.ThimaDRAFT_2156 6.23e-63 196.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales 135613|Chromatiales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_439408_2 697282.Mettu_0765 2.87e-11 62.8 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1XDK8@135618|Methylococcales 135618|Methylococcales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1028022_1 1331060.RLDS_20460 1.12e-35 137.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2K0ZS@204457|Sphingomonadales 204457|Sphingomonadales T nitrogen fixation sensor protein fixL - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS k59_147297_1 1123060.JONP01000004_gene611 0.000435 41.6 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2UGK6@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_147297_2 1121927.GOHSU_01_00350 9.63e-40 152.0 COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4GC8K@85026|Gordoniaceae 201174|Actinobacteria KLT Protein tyrosine kinase pknL GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_343583_1 754476.Q7A_1443 7.27e-16 79.7 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,461RK@72273|Thiotrichales 72273|Thiotrichales O Tetratricopeptide repeat - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_8 k59_243855_1 1168034.FH5T_12545 1.94e-89 272.0 COG2815@1|root,COG2815@2|Bacteria,4NSUI@976|Bacteroidetes,2FPS4@200643|Bacteroidia 976|Bacteroidetes S PASTA domain protein spk1 - 2.7.11.1,6.3.2.4 ko:K01921,ko:K08884,ko:K12132 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01001,ko01011 - - - PASTA k59_543048_2 376686.Fjoh_0254 2.41e-32 115.0 COG2827@1|root,COG2827@2|Bacteria,4NSI7@976|Bacteroidetes,1I2RZ@117743|Flavobacteriia,2NXN4@237|Flavobacterium 976|Bacteroidetes L endonuclease containing a URI domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_443436_2 1168034.FH5T_02780 4.16e-41 147.0 COG0457@1|root,COG0457@2|Bacteria,4NG1I@976|Bacteroidetes,2FQPG@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_674160_1 1049564.TevJSym_ak00850 2.38e-67 208.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1J685@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate kdsC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECO26_1355.ECO26_4302 Hydrolase_3 k59_934991_1 526218.Sterm_1122 2.34e-109 320.0 COG0149@1|root,COG0149@2|Bacteria,378PF@32066|Fusobacteria 32066|Fusobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_934991_2 572544.Ilyop_1516 2.51e-44 156.0 COG0696@1|root,COG0696@2|Bacteria,378G0@32066|Fusobacteria 32066|Fusobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_543054_1 1121019.AUMN01000019_gene3865 4.1e-09 58.5 COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,1W7R7@1268|Micrococcaceae 201174|Actinobacteria E Belongs to the AlaDH PNT family ald GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030312,GO:0036293,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_543054_2 1121033.AUCF01000010_gene4500 7.22e-53 172.0 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,2JRUZ@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx k59_1000406_2 426117.M446_1580 4.18e-11 62.8 COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,2TYKE@28211|Alphaproteobacteria,1JZI1@119045|Methylobacteriaceae 28211|Alphaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_279199_1 563040.Saut_1687 9.2e-97 288.0 COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,42NNI@68525|delta/epsilon subdivisions,2YNBH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) cmoA GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25,Methyltransf_31 k59_279199_2 1122211.JMLW01000001_gene2223 6.9e-18 79.7 COG2227@1|root,COG2227@2|Bacteria,1R10F@1224|Proteobacteria 1224|Proteobacteria H Methyltransferase domain - - - - - - - - - - - - - k59_868692_1 1049564.TevJSym_ap00510 4.79e-129 389.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341,ko:K05559 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_868692_2 1219375.CM002139_gene3889 5.44e-05 46.2 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1X3SW@135614|Xanthomonadales 135614|Xanthomonadales C NADH ubiquinone oxidoreductase subunit nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1031974_1 1283300.ATXB01000001_gene1084 2.45e-70 233.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XE6A@135618|Methylococcales 135618|Methylococcales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - COX15-CtaA,SRP54,SRP54_N k59_543060_1 1144307.PMI04_02525 1.03e-37 135.0 2DNBN@1|root,32WN2@2|Bacteria,1N5BF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3313) - - - - - - - - - - - - DUF3313 k59_575426_1 1168034.FH5T_20460 2.26e-94 297.0 COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,2FR3B@200643|Bacteroidia 976|Bacteroidetes O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Glyco_hydro_127,Glyco_hydro_76,Thioredox_DsbH k59_216449_1 179408.Osc7112_2821 2.24e-55 191.0 COG1797@1|root,COG1797@2|Bacteria,1G1SF@1117|Cyanobacteria,1H8CH@1150|Oscillatoriales 1117|Cyanobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_183889_1 177437.HRM2_12410 6.13e-45 167.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_935016_1 395965.Msil_1614 9.16e-28 116.0 COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2TV2M@28211|Alphaproteobacteria,3NAUY@45404|Beijerinckiaceae 28211|Alphaproteobacteria P Phosphate transport regulator - - - - - - - - - - - - - k59_216452_1 682795.AciX8_1157 1.34e-17 87.4 COG2273@1|root,COG2273@2|Bacteria,3Y9CU@57723|Acidobacteria,2JM2F@204432|Acidobacteriia 204432|Acidobacteriia G Carbohydrate-binding protein of the ER - - - - - - - - - - - - Malectin k59_836466_1 113395.AXAI01000005_gene4150 1.27e-127 388.0 COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,2TVI2@28211|Alphaproteobacteria,3JUS1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_347623_1 556263.FSEG_02129 3.88e-24 99.4 COG3619@1|root,COG3619@2|Bacteria,378ME@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF1275) - - - - - - - - - - - - DUF1275 k59_674187_1 545695.TREAZ_3449 8.87e-49 177.0 COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes 203691|Spirochaetes J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_737274_1 1198232.CYCME_0743 5.44e-260 715.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,45ZSW@72273|Thiotrichales 72273|Thiotrichales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_50212_1 1121405.dsmv_1666 4.66e-57 199.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_379971_1 1249480.B649_07465 2.33e-58 195.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2YMAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_609348_1 935567.JAES01000007_gene1860 8.67e-59 197.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales 135614|Xanthomonadales S cAMP biosynthetic process - - - - - - - - - - - - - k59_1032819_1 1123253.AUBD01000002_gene1196 1.22e-23 107.0 COG1807@1|root,COG1807@2|Bacteria,1MXH5@1224|Proteobacteria,1RSQE@1236|Gammaproteobacteria,1X415@135614|Xanthomonadales 135614|Xanthomonadales M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 k59_801241_1 572480.Arnit_1435 7.89e-44 143.0 COG2161@1|root,COG2161@2|Bacteria,1N07B@1224|Proteobacteria,42UIW@68525|delta/epsilon subdivisions 1224|Proteobacteria D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox k59_801241_2 572480.Arnit_1436 4.46e-23 89.7 COG4115@1|root,COG4115@2|Bacteria,1N0WH@1224|Proteobacteria,42U3X@68525|delta/epsilon subdivisions,2YSVU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S YoeB-like toxin of bacterial type II toxin-antitoxin system - - - - - - - - - - - - YoeB_toxin k59_512069_1 443143.GM18_0348 1.11e-12 72.8 COG3863@1|root,COG3863@2|Bacteria,1R3R2@1224|Proteobacteria,42S8G@68525|delta/epsilon subdivisions,2WNZG@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 k59_543915_1 1120792.JAFV01000001_gene320 4.36e-25 110.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2TRVM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S phosphatase - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_609359_1 768671.ThimaDRAFT_0083 1.32e-16 78.2 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1X257@135613|Chromatiales 135613|Chromatiales P PFAM von Willebrand factor type A - - - - - - - - - - - - VWA k59_609359_2 153948.NAL212_0995 1.41e-37 130.0 2E0T4@1|root,32WAV@2|Bacteria,1N19Z@1224|Proteobacteria,2VTHM@28216|Betaproteobacteria,373HE@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_576313_1 404380.Gbem_3167 2.33e-09 62.8 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42PY0@68525|delta/epsilon subdivisions,2WJ2Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_576313_2 1005048.CFU_3223 1.79e-45 157.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4730X@75682|Oxalobacteraceae 28216|Betaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_902726_1 177437.HRM2_18930 2.15e-24 97.4 COG3474@1|root,COG3474@2|Bacteria,1QUNA@1224|Proteobacteria,42PVG@68525|delta/epsilon subdivisions,2WJ7N@28221|Deltaproteobacteria,2MIQK@213118|Desulfobacterales 28221|Deltaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrom_CIII,Cytochrome_C7 k59_902726_2 1121405.dsmv_1078 1.78e-42 154.0 COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria,2MI3Z@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family qrcB - - ko:K08357 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1032830_1 1333856.L686_13125 9.49e-126 365.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1Z0UP@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024 LYTB k59_217342_1 748658.KB907312_gene1441 5.38e-73 238.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1WWBM@135613|Chromatiales 135613|Chromatiales E Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_15204_1 999141.GME_15915 3.87e-83 275.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XHB4@135619|Oceanospirillales 135619|Oceanospirillales E Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_801257_1 1379281.AVAG01000071_gene734 7.57e-70 226.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,42MQ1@68525|delta/epsilon subdivisions,2WJII@28221|Deltaproteobacteria,2M9HZ@213115|Desulfovibrionales 28221|Deltaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_217352_1 1168034.FH5T_04165 2.14e-56 177.0 COG4191@1|root,COG4191@2|Bacteria,4NSNP@976|Bacteroidetes,2FTSX@200643|Bacteroidia 976|Bacteroidetes T Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF3467 k59_217352_2 1168034.FH5T_04170 1.1e-16 78.6 COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,2FMWR@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_217353_1 927658.AJUM01000047_gene2938 3.94e-26 109.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,4NDVV@976|Bacteroidetes,2FMFI@200643|Bacteroidia,3XIJU@558415|Marinilabiliaceae 976|Bacteroidetes S Probable molybdopterin binding domain cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_869620_1 1168034.FH5T_11900 4.49e-131 383.0 COG0771@1|root,COG0771@2|Bacteria,4NEFF@976|Bacteroidetes,2FP0X@200643|Bacteroidia 976|Bacteroidetes M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_869620_2 1168034.FH5T_11905 1.73e-19 87.8 COG0772@1|root,COG0772@2|Bacteria,4NFIM@976|Bacteroidetes,2FM93@200643|Bacteroidia 976|Bacteroidetes D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_641939_1 1504981.KO116_3656 1.31e-56 184.0 COG3335@1|root,COG3335@2|Bacteria,1RKBQ@1224|Proteobacteria,1SZ96@1236|Gammaproteobacteria,1XRNN@135619|Oceanospirillales 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_641939_2 390235.PputW619_2535 4.21e-08 54.7 COG3415@1|root,COG3415@2|Bacteria 2|Bacteria L Transposase - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_28,HTH_29,HTH_32,LZ_Tnp_IS481 k59_935890_1 324925.Ppha_0360 1.25e-28 116.0 COG0745@1|root,COG2202@1|root,COG3829@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,1FF5G@1090|Chlorobi 1090|Chlorobi KT SMART PAS domain containing protein - - - - - - - - - - - - PAS_9 k59_85524_2 237368.SCABRO_01917 5.24e-42 147.0 COG0264@1|root,COG0264@2|Bacteria,2IZGM@203682|Planctomycetes 203682|Planctomycetes J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_85524_3 4929.XP_001483124.1 4.7e-16 84.3 COG0052@1|root,KOG0832@2759|Eukaryota,38BFI@33154|Opisthokonta,3NV5T@4751|Fungi,3QNVW@4890|Ascomycota,3RTSC@4891|Saccharomycetes,47AJS@766764|Debaryomycetaceae 4751|Fungi J Belongs to the universal ribosomal protein uS2 family - GO:0000049,GO:0000313,GO:0000314,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_968248_1 1121937.AUHJ01000036_gene2807 9.17e-95 287.0 COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,1RN1I@1236|Gammaproteobacteria,4640P@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_280042_1 643867.Ftrac_1703 1.63e-59 187.0 28W66@1|root,2ZI6U@2|Bacteria,4P8V7@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_706765_1 768066.HELO_3861 7.88e-93 279.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1XHIU@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_837372_1 1403313.AXBR01000007_gene241 1.83e-16 85.5 COG1653@1|root,COG1653@2|Bacteria,1UY14@1239|Firmicutes,4HEMF@91061|Bacilli,1ZQ33@1386|Bacillus 91061|Bacilli G COG1653 ABC-type sugar transport system, periplasmic component yurO - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 k59_837372_2 1122915.AUGY01000002_gene7395 3.22e-93 291.0 COG1653@1|root,COG1653@2|Bacteria,1TR3D@1239|Firmicutes,4HCHA@91061|Bacilli,26TVS@186822|Paenibacillaceae 91061|Bacilli G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 k59_675146_1 1173027.Mic7113_3921 6.07e-80 270.0 COG0515@1|root,COG0642@1|root,COG0745@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,Guanylate_cyc,HATPase_c,HisKA,PAS_4,Pkinase,Response_reg k59_152225_1 332101.JIBU02000020_gene2058 1.26e-23 102.0 COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,248MY@186801|Clostridia,36GD1@31979|Clostridiaceae 186801|Clostridia C Alcohol dehydrogenase GroES-like domain - - 1.1.1.303,1.1.1.4 ko:K00004 ko00650,map00650 - R02855,R02946,R10504 RC00205,RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_N_assoc,ADH_zinc_N k59_313533_1 1397528.Q671_05535 9.44e-53 180.0 COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,1XIRN@135619|Oceanospirillales 135619|Oceanospirillales C COG2864 Cytochrome b subunit of formate dehydrogenase - - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB k59_184783_1 1269813.ATUL01000008_gene1534 2.59e-46 159.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales 135613|Chromatiales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_184783_2 765911.Thivi_0625 1.05e-07 50.1 2E5B5@1|root,33039@2|Bacteria,1NDK8@1224|Proteobacteria,1SFKE@1236|Gammaproteobacteria,1WZDR@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_772067_1 1396141.BATP01000020_gene84 3.73e-90 297.0 COG2010@1|root,COG2133@1|root,COG3506@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,COG3506@2|Bacteria,46TW3@74201|Verrucomicrobia,2IVDX@203494|Verrucomicrobiae 74201|Verrucomicrobia G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - Cadherin,GSDH,Laminin_G_3 k59_869644_1 130081.XP_005709039.1 2.44e-15 78.6 2CN3J@1|root,2QTQC@2759|Eukaryota 2759|Eukaryota S Domain of unknown function (DUF5107) - - - - - - - - - - - - DUF5107 k59_412243_1 396588.Tgr7_3279 1.34e-146 419.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales 135613|Chromatiales F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_412244_2 335543.Sfum_3894 1.14e-08 59.3 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,42SV9@68525|delta/epsilon subdivisions,2WPXX@28221|Deltaproteobacteria,2MRUJ@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM Phosphoribosyltransferase - - - - - - - - - - - - Pribosyltran k59_543962_1 56780.SYN_00295 4.08e-113 359.0 COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Alpha amylase catalytic - - - - - - - - - - - - Alpha-amylase,GDE_C,GDE_N k59_869648_2 926569.ANT_27900 2.78e-55 186.0 COG4603@1|root,COG4603@2|Bacteria,2G6MU@200795|Chloroflexi 200795|Chloroflexi S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_152240_1 96561.Dole_1115 1.95e-23 99.4 COG0189@1|root,COG0189@2|Bacteria,1RH7D@1224|Proteobacteria,42SDD@68525|delta/epsilon subdivisions,2WPGS@28221|Deltaproteobacteria,2MKA2@213118|Desulfobacterales 28221|Deltaproteobacteria HJ PFAM RimK domain protein ATP-grasp - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_51079_1 387093.SUN_2327 1.53e-131 375.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2YN05@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_743206_1 1446473.JHWH01000023_gene2895 1.65e-53 169.0 COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2UC8C@28211|Alphaproteobacteria,2PX7U@265|Paracoccus 28211|Alphaproteobacteria E Sarcosine oxidase, delta subunit family soxD - 1.5.3.1 ko:K00304 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - SoxD k59_743206_2 412597.AEPN01000004_gene3200 5.07e-92 280.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,2PU4G@265|Paracoccus 28211|Alphaproteobacteria E FAD dependent oxidoreductase soxB3 - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_385612_2 180332.JTGN01000024_gene1694 5.07e-46 165.0 COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,248XD@186801|Clostridia 186801|Clostridia K CobW P47K family protein - - - - - - - - - - - - CobW_C,cobW k59_385612_3 1291050.JAGE01000001_gene1385 3.97e-93 305.0 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,3WI2J@541000|Ruminococcaceae 186801|Clostridia C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_385612_4 545695.TREAZ_3007 2.6e-33 128.0 COG0145@1|root,COG0145@2|Bacteria,2JAMB@203691|Spirochaetes 203691|Spirochaetes EQ Protein of unknown function (DUF1638) - - - - - - - - - - - - DUF1638 k59_385612_5 742733.HMPREF9469_05004 1.48e-29 123.0 COG1879@1|root,COG1879@2|Bacteria,1VTWD@1239|Firmicutes,24YC2@186801|Clostridia 186801|Clostridia K COG COG1879 ABC-type sugar transport system, periplasmic component - - - - - - - - - - - - LacI,Peripla_BP_4 k59_385612_6 180332.JTGN01000024_gene1676 4.23e-84 256.0 COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia 186801|Clostridia S TIGRFAM methyltransferase cognate corrinoid proteins, Methanosarcina family - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2 k59_874894_1 472759.Nhal_3425 2.72e-89 275.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria 1236|Gammaproteobacteria O PFAM peptidase - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_712025_1 550540.Fbal_1103 7.01e-98 303.0 COG2211@1|root,COG2211@2|Bacteria,1MX4Z@1224|Proteobacteria,1RRNW@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major facilitator superfamily malT - - ko:K16211 - - - - ko00000,ko02000 2.A.2.6 - - MFS_1 k59_973233_1 1049564.TevJSym_ab01230 1.88e-138 398.0 COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_973233_2 998674.ATTE01000001_gene214 1.56e-59 197.0 COG0501@1|root,COG0501@2|Bacteria,1R0V5@1224|Proteobacteria,1SBIF@1236|Gammaproteobacteria 1236|Gammaproteobacteria O peptidase M48, Ste24p - - - - - - - - - - - - Peptidase_M48 k59_973233_3 998674.ATTE01000001_gene213 7.54e-52 169.0 COG0393@1|root,COG0393@2|Bacteria,1N6BK@1224|Proteobacteria,1SAFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k59_973233_4 998674.ATTE01000001_gene212 1.09e-51 165.0 COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1T189@1236|Gammaproteobacteria,463TY@72273|Thiotrichales 72273|Thiotrichales S Putative heavy-metal-binding - - - - - - - - - - - - YbjQ_1 k59_842368_1 1150621.SMUL_2567 3.13e-104 310.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,42N94@68525|delta/epsilon subdivisions,2YMHM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_20483_2 713587.THITH_06735 9.34e-56 189.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXFK@135613|Chromatiales 135613|Chromatiales GM nucleoside-diphosphate sugar epimerase - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_1038506_1 1192034.CAP_3728 6.54e-72 235.0 COG3509@1|root,COG3509@2|Bacteria 2|Bacteria Q xylan catabolic process - GO:0005575,GO:0005576 - ko:K03932 - - - - ko00000 - CE1 - Abhydrolase_2,Big_3_3,CBM_2,Glyco_hydro_62,Inhibitor_I9,Peptidase_S8,RicinB_lectin_2 k59_777219_1 398579.Spea_0261 2.24e-50 181.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,2QBA4@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM Aldehyde ferredoxin oxidoreductase ydhV GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0030151,GO:0033719,GO:0043167,GO:0043169,GO:0043546,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0097159,GO:1901363 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_1006457_1 1285586.H131_12753 5.45e-13 71.2 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,3IZG9@400634|Lysinibacillus 91061|Bacilli Q COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_517863_1 244581.IM40_09480 1.08e-30 118.0 COG4974@1|root,COG4974@2|Bacteria,1MZES@1224|Proteobacteria,2U7WS@28211|Alphaproteobacteria,47FNN@766|Rickettsiales 766|Rickettsiales L Plasmid pRiA4b ORF-3-like protein - - - - - - - - - - - - PRiA4_ORF3 k59_190070_1 2340.JV46_28010 4.24e-94 290.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1JC0J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_254197_1 873513.HMPREF6485_0232 3.46e-47 166.0 COG3507@1|root,COG3507@2|Bacteria,4NGA5@976|Bacteroidetes,2FMIM@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0046556,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 k59_254197_2 743722.Sph21_2647 9.65e-37 137.0 COG3507@1|root,COG3507@2|Bacteria,4NGA5@976|Bacteroidetes,1IP09@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0046556,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 k59_614610_2 160799.PBOR_26795 8.29e-36 135.0 COG4670@1|root,COG4670@2|Bacteria,1TP5H@1239|Firmicutes,4IS4T@91061|Bacilli,26VUY@186822|Paenibacillaceae 91061|Bacilli I Belongs to the 3-oxoacid CoA-transferase family pct - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_777225_1 861299.J421_1699 2.2e-17 88.2 COG2866@1|root,COG2866@2|Bacteria,1ZSQ1@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_647376_1 931276.Cspa_c22640 2.74e-71 221.0 COG2057@1|root,COG2057@2|Bacteria,1TNY5@1239|Firmicutes,247ZM@186801|Clostridia,36GAR@31979|Clostridiaceae 186801|Clostridia I 3-oxoacid CoA-transferase, B subunit - - 2.8.3.8,2.8.3.9 ko:K01035 ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020 - R01179,R01359,R01365,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_806506_1 1121912.AUHD01000005_gene1754 1.8e-73 240.0 COG3420@1|root,COG3420@2|Bacteria,4PMG9@976|Bacteroidetes,1IKNW@117743|Flavobacteriia 976|Bacteroidetes P Right handed beta helix region - - - - - - - - - - - - Beta_helix k59_56225_1 1223410.KN050846_gene665 1.05e-76 245.0 COG0187@1|root,COG0187@2|Bacteria,4NF18@976|Bacteroidetes,1HWNY@117743|Flavobacteriia 976|Bacteroidetes L Type IIA topoisomerase (DNA gyrase topo II topoisomerase IV) B subunit parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_806507_1 1232666.JANE01000031_gene1378 2.98e-58 187.0 2DB8K@1|root,2Z7S1@2|Bacteria,1TRA1@1239|Firmicutes,4HBIE@91061|Bacilli,4GYUZ@90964|Staphylococcaceae 91061|Bacilli G Streptomycin adenylyltransferase aadK - - ko:K05593 - - - - ko00000,ko01000,ko01504 - - - Adenyl_transf k59_806507_2 1232666.JANE01000031_gene1379 1.2e-42 145.0 COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,4ISTQ@91061|Bacilli,4H1TW@90964|Staphylococcaceae 91061|Bacilli Q Protein of unknown function (DUF1698) - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_647381_1 1465751.W8QN24_9VIRU 7.64e-64 210.0 4QHKZ@10239|Viruses,4R02U@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_450266_1 1049564.TevJSym_an00300 8.62e-91 276.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1J4VG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1509 Lysine 2,3-aminomutase epmB GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016866,GO:0016869,GO:0048037,GO:0051536,GO:0051539,GO:0051540 5.4.3.2 ko:K01843,ko:K19810 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000,ko03012 - - iECH74115_1262.ECH74115_5662,iECIAI39_1322.ECIAI39_4611,iS_1188.S4569 Fer4_12,Fer4_14,Radical_SAM k59_158044_1 472759.Nhal_2557 8.93e-81 250.0 COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,1S3T8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ribonuclease BN - - - - - - - - - - - - Virul_fac_BrkB k59_647387_1 631362.Thi970DRAFT_00975 2.23e-32 120.0 COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,1S2WZ@1236|Gammaproteobacteria,1WWAG@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF533) - - - - - - - - - - - - DUF533 k59_647387_2 1248232.BANQ01000150_gene4009 1.78e-18 80.1 COG3743@1|root,COG3743@2|Bacteria,1RA3K@1224|Proteobacteria,1S9SF@1236|Gammaproteobacteria,1XXMJ@135623|Vibrionales 135623|Vibrionales S Domain of unknown function (DUF4332) - - - - - - - - - - - - DUF4332 k59_549541_1 1101190.ARWB01000001_gene2062 1.43e-19 92.8 2DN7H@1|root,32VYK@2|Bacteria,1QUPN@1224|Proteobacteria,2TW3K@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_318506_1 387093.SUN_0544 9.06e-73 232.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2YMTB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_124064_1 477228.YO5_14480 3.43e-81 254.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1Z33S@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_318508_1 748449.Halha_2508 1.4e-86 263.0 COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,3WABY@53433|Halanaerobiales 186801|Clostridia G fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_712052_1 1042377.AFPJ01000032_gene2743 1.27e-120 378.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RS1Q@1236|Gammaproteobacteria,469PS@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_20528_1 999141.GME_03722 5.62e-97 292.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XIQQ@135619|Oceanospirillales 135619|Oceanospirillales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_614633_1 1049564.TevJSym_ar00050 6.11e-17 82.0 COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1J6N7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sporulation related domain dedD - - ko:K03749 - - - - ko00000 - - - SPOR k59_647396_1 1449345.JHWC01000006_gene936 1.49e-05 47.8 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2YMEM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_56248_1 395493.BegalDRAFT_2280 1.68e-80 249.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,461Y0@72273|Thiotrichales 72273|Thiotrichales M Polysaccharide biosynthesis protein - - 5.1.3.7 ko:K02473 ko00520,ko01100,map00520,map01100 - R00418 RC00289 ko00000,ko00001,ko01000 - - - Epimerase k59_124073_1 749222.Nitsa_0052 3e-21 87.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2YPMF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_254230_1 1408473.JHXO01000001_gene2526 1.94e-75 237.0 COG0626@1|root,COG0626@2|Bacteria,4PKE6@976|Bacteroidetes,2G3E3@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine megL - 4.4.1.11,4.4.1.8 ko:K01760,ko:K01761 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00654,R00782,R01286,R02408,R04770,R04941 RC00056,RC00069,RC00196,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_254230_2 236814.IX39_06300 8.56e-18 83.2 COG2377@1|root,COG2377@2|Bacteria,4NFZU@976|Bacteroidetes,1HWX7@117743|Flavobacteriia,3ZQ3H@59732|Chryseobacterium 976|Bacteroidetes O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_777256_1 572544.Ilyop_0272 6.69e-153 445.0 COG4670@1|root,COG4670@2|Bacteria,379F4@32066|Fusobacteria 32066|Fusobacteria I Coenzyme A transferase - - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_417121_1 749222.Nitsa_0054 1.24e-05 47.0 2A1AT@1|root,30PHH@2|Bacteria,1Q6P3@1224|Proteobacteria,433GY@68525|delta/epsilon subdivisions,2YSHB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_907854_2 1179778.PMM47T1_05664 7.25e-20 88.2 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Type I secretion membrane fusion protein, HlyD lssD - - ko:K12542 - M00330 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1 - - Biotin_lipoyl_2,HlyD_3 k59_385675_1 768671.ThimaDRAFT_0164 2e-76 242.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1WWHM@135613|Chromatiales 135613|Chromatiales Q TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_842409_1 876044.IMCC3088_2824 7.06e-10 57.0 COG3572@1|root,COG3572@2|Bacteria,1N0R0@1224|Proteobacteria 1224|Proteobacteria H Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_842409_2 1038922.PflQ2_3051 5.71e-56 181.0 2ANPA@1|root,31DNS@2|Bacteria,1REM3@1224|Proteobacteria,1SY9Z@1236|Gammaproteobacteria,1YQDA@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Protein of unknown function (DUF3833) - - - - - - - - - - - - DUF3833 k59_450303_1 317619.ANKN01000230_gene216 3.7e-34 126.0 COG3001@1|root,COG3001@2|Bacteria,1G040@1117|Cyanobacteria,1MM08@1212|Prochloraceae 1117|Cyanobacteria G Ribulosamine erythrulosamine 3-kinase potentially involved in protein deglycation - GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 - - - - - - - - - - Fructosamin_kin k59_190109_1 470145.BACCOP_00969 2.62e-57 192.0 COG4124@1|root,COG4124@2|Bacteria,4NEZG@976|Bacteroidetes,2FPAD@200643|Bacteroidia,4AM74@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 26 family - - 3.2.1.78 ko:K01218,ko:K19355 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - Glyco_hydro_26 k59_581893_1 97138.C820_01424 4.81e-47 170.0 COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,36DF6@31979|Clostridiaceae 186801|Clostridia C Radical SAM - - 1.21.98.3 ko:K04034 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06268,R06269,R06270 RC00741,RC01491,RC01492 ko00000,ko00001,ko01000 - - - B12-binding,DUF4080,Radical_SAM k59_56261_1 316057.RPD_3423 1.8e-64 210.0 COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,2TTAU@28211|Alphaproteobacteria 28211|Alphaproteobacteria E catalyzes the formation of indole and pyruvate from tryptophan tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_712074_1 1346330.M472_09480 1.14e-50 183.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,4NDXS@976|Bacteroidetes 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_743264_1 1095769.CAHF01000006_gene1884 2.72e-12 63.9 COG0071@1|root,COG0071@2|Bacteria,1N0RH@1224|Proteobacteria,2VVUG@28216|Betaproteobacteria,47820@75682|Oxalobacteraceae 28216|Betaproteobacteria O Hsp20/alpha crystallin family - - - - - - - - - - - - HSP20 k59_743264_2 1223521.BBJX01000001_gene1022 5.52e-51 170.0 COG4106@1|root,COG4106@2|Bacteria,1QZC8@1224|Proteobacteria,2WHJN@28216|Betaproteobacteria,4AJYU@80864|Comamonadaceae 28216|Betaproteobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_647420_1 323850.Shew_0984 1.19e-68 223.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQX@1236|Gammaproteobacteria,2QCYP@267890|Shewanellaceae 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_417135_1 572544.Ilyop_2810 1.54e-53 175.0 2EFRP@1|root,339HP@2|Bacteria,37B3E@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_417135_2 546275.FUSPEROL_02263 4.47e-33 132.0 COG0210@1|root,COG0210@2|Bacteria 2|Bacteria L ATP-dependent DNA helicase activity helD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1902494 3.6.4.12 ko:K03658 - - - - ko00000,ko01000,ko03400 - - - Helicase_IV_N,UvrD-helicase,UvrD_C,zf-C4_Topoisom k59_285478_1 439235.Dalk_3994 7.4e-32 124.0 COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,42U8I@68525|delta/epsilon subdivisions,2WQCY@28221|Deltaproteobacteria,2MNWM@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_385700_1 1123519.PSJM300_16300 1.1e-15 81.6 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1Z2CU@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CZB,HAMP,MCPsignal,dCache_3 k59_353629_1 706587.Desti_2042 2.08e-98 304.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_806553_1 1166018.FAES_4556 3.52e-19 83.6 29AZZ@1|root,2ZXYX@2|Bacteria,4NP6M@976|Bacteroidetes,47Q19@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_806553_2 1168034.FH5T_05580 5.24e-163 472.0 COG1022@1|root,COG1022@2|Bacteria,4NEA4@976|Bacteroidetes,2FNK9@200643|Bacteroidia 976|Bacteroidetes I AMP-binding enzyme fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_190124_1 517418.Ctha_1390 8.62e-70 228.0 COG1274@1|root,COG1274@2|Bacteria,1FDFQ@1090|Chlorobi 1090|Chlorobi H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_56271_1 1249627.D779_4159 1.86e-75 237.0 COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria,1WWCH@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of dihydroorotate to orotate - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_614669_1 563040.Saut_0576 4.25e-78 243.0 COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2YN0V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Potassium channel protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_874989_1 292415.Tbd_2337 2.44e-24 106.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1KRHD@119069|Hydrogenophilales 119069|Hydrogenophilales M Organic solvent tolerance protein - - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA_C k59_777297_1 1249480.B649_07215 1.15e-114 335.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2YM8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_124132_1 387092.NIS_1238 8.99e-28 107.0 COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,42TC2@68525|delta/epsilon subdivisions,2YPKS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterised protein family (UPF0227) - - - ko:K07000 - - - - ko00000 - - - UPF0227 k59_842438_1 1123072.AUDH01000003_gene828 7.08e-05 50.1 COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,2TVP1@28211|Alphaproteobacteria,2JPFD@204441|Rhodospirillales 204441|Rhodospirillales M COG4591 ABC-type transport system, involved in lipoprotein release, permease component - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_482185_1 765913.ThidrDRAFT_1865 5.66e-33 126.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1SYHR@1236|Gammaproteobacteria,1WZZ5@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_482185_2 1249627.D779_2839 1.23e-40 148.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1SYHR@1236|Gammaproteobacteria,1WZZ5@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_549601_1 522306.CAP2UW1_1590 1.12e-78 264.0 COG0296@1|root,COG1523@1|root,COG0296@2|Bacteria,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_190977_12 1304885.AUEY01000061_gene2829 1.03e-08 56.6 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42R5Z@68525|delta/epsilon subdivisions,2WMPN@28221|Deltaproteobacteria,2MJH1@213118|Desulfobacterales 28221|Deltaproteobacteria H Thiamine monophosphate synthase thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_778218_1 1265505.ATUG01000003_gene320 3.49e-53 188.0 COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria,2MHMP@213118|Desulfobacterales 28221|Deltaproteobacteria I Phosphate acyltransferases - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Acyltransferase,Hydrolase_4 k59_518860_1 395493.BegalDRAFT_1884 2.25e-95 305.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,45ZUB@72273|Thiotrichales 72273|Thiotrichales C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_550391_1 1254432.SCE1572_09950 1.29e-38 144.0 COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria,2YV97@29|Myxococcales 28221|Deltaproteobacteria O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin k59_93102_1 1049564.TevJSym_aa01800 1.01e-59 197.0 COG1055@1|root,COG1055@2|Bacteria 2|Bacteria P arsenite transmembrane transporter activity - - - - - - - - - - - - CitMHS k59_418978_1 1537917.JU82_07625 5.61e-83 250.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2YMQ6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_256231_1 709032.Sulku_2228 6.45e-108 335.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2YMJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_616554_1 1266914.ATUK01000018_gene686 1.01e-40 150.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales 135613|Chromatiales S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP k59_876772_1 123214.PERMA_0385 8.77e-50 184.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria 2|Bacteria T EAL domain yliE GO:0003674,GO:0003824,GO:0008081,GO:0016787,GO:0016788,GO:0042578,GO:0071111 3.1.4.52 ko:K20964 ko05111,map05111 - - - ko00000,ko00001,ko01000 - - - CHASE9,EAL,FIST,FIST_C,GGDEF,PAS_9,Peripla_BP_3 k59_876772_2 589865.DaAHT2_1868 9.59e-115 342.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N1I@68525|delta/epsilon subdivisions,2WNI2@28221|Deltaproteobacteria 28221|Deltaproteobacteria C cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C,Haem_bd,Pkinase k59_58637_1 926559.JoomaDRAFT_2639 4.47e-44 152.0 COG0500@1|root,COG0500@2|Bacteria,4NGY5@976|Bacteroidetes,1HXZX@117743|Flavobacteriia 976|Bacteroidetes Q Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_320237_1 1408473.JHXO01000008_gene2753 6.37e-92 287.0 COG1132@1|root,COG1132@2|Bacteria,4NFQG@976|Bacteroidetes,2G2XP@200643|Bacteroidia 976|Bacteroidetes V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_584008_1 519989.ECTPHS_13365 1.57e-40 145.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1WXT0@135613|Chromatiales 135613|Chromatiales S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_584008_2 631362.Thi970DRAFT_03124 4e-113 334.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WW4I@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_943404_1 1304284.L21TH_0368 4.55e-62 204.0 COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,36DQ8@31979|Clostridiaceae 186801|Clostridia S peptidase U62, modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_224520_1 903818.KI912268_gene2387 4.59e-43 159.0 COG0277@1|root,COG0277@2|Bacteria 2|Bacteria C FAD linked oxidase domain protein - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - BBE,FAD_binding_4 k59_160298_1 1487921.DP68_01000 1.13e-92 295.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,36DUH@31979|Clostridiaceae 186801|Clostridia E Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans k59_160298_3 1487923.DP73_02805 3.35e-96 285.0 COG0288@1|root,COG0288@2|Bacteria,1V0AW@1239|Firmicutes,249P8@186801|Clostridia,2607R@186807|Peptococcaceae 186801|Clostridia P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_160298_4 1121324.CLIT_23c02630 7.07e-179 525.0 COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes 1239|Firmicutes T Diguanylate cyclase - - - - - - - - - - - - GAF_2,GGDEF,HD,HD_5,HisKA_7TM,PAS_3,PAS_4,PAS_9 k59_160298_5 572544.Ilyop_0968 5e-34 122.0 COG1622@1|root,COG1622@2|Bacteria,37CJY@32066|Fusobacteria 2|Bacteria C cytochrome c oxidase subunit II - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1 k59_160298_6 572544.Ilyop_1170 5.4e-188 533.0 COG0452@1|root,COG0452@2|Bacteria,37970@32066|Fusobacteria 32066|Fusobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_160298_7 572544.Ilyop_1140 6.91e-52 168.0 COG1846@1|root,COG1846@2|Bacteria,37B11@32066|Fusobacteria 32066|Fusobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - MarR k59_160298_8 999411.HMPREF1092_02882 6.04e-78 244.0 COG5495@1|root,COG5495@2|Bacteria,1UZZU@1239|Firmicutes,249YF@186801|Clostridia,36FY5@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF2520) - - - - - - - - - - - - DUF2520,F420_oxidored,Rossmann-like k59_160298_9 1211817.CCAT010000068_gene1326 1.09e-104 310.0 COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,36EKX@31979|Clostridiaceae 186801|Clostridia H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_876784_1 929558.SMGD1_0803 1.96e-62 204.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2YMBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1055 Na H antiporter NhaD and related arsenite - - - - - - - - - - - - CitMHS k59_192187_1 879212.DespoDRAFT_02109 3.26e-40 148.0 COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,42U9T@68525|delta/epsilon subdivisions,2WQPQ@28221|Deltaproteobacteria,2MK7H@213118|Desulfobacterales 28221|Deltaproteobacteria S protein conserved in bacteria (DUF2064) - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_943420_1 1168034.FH5T_08810 1.97e-137 397.0 COG0489@1|root,COG0489@2|Bacteria,4NF5I@976|Bacteroidetes,2FKYK@200643|Bacteroidia 976|Bacteroidetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1008351_1 709032.Sulku_1659 7.32e-45 163.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42QQC@68525|delta/epsilon subdivisions,2YPD6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T SMART GGDEF domain containing protein - - - - - - - - - - - - GGDEF,Response_reg k59_1008351_2 1051632.TPY_0110 1.18e-06 52.0 COG0607@1|root,COG0607@2|Bacteria,1VES3@1239|Firmicutes,24UVG@186801|Clostridia,3WDJW@538999|Clostridiales incertae sedis 186801|Clostridia P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_388017_1 1168289.AJKI01000008_gene746 3.9e-18 84.0 COG3550@1|root,COG3550@2|Bacteria,4NG6N@976|Bacteroidetes,2FMN8@200643|Bacteroidia 976|Bacteroidetes S HipA-like C-terminal domain protein - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - HipA_C k59_388017_2 68223.JNZY01000008_gene2768 7.09e-17 83.2 COG5297@1|root,COG5297@2|Bacteria,2GK92@201174|Actinobacteria 201174|Actinobacteria G Belongs to the glycosyl hydrolase family 6 - - 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CBM_2,Glyco_hydro_6 k59_452704_1 1254432.SCE1572_44870 7.76e-81 255.0 COG3104@1|root,COG3104@2|Bacteria,1P6K2@1224|Proteobacteria 1224|Proteobacteria E PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 k59_551822_1 743721.Psesu_1225 9.94e-13 68.6 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1X4MV@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_551822_2 266117.Rxyl_2884 1.24e-21 92.4 COG1438@1|root,COG1438@2|Bacteria 2|Bacteria K arginine binding argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k59_551822_3 1123228.AUIH01000034_gene2791 3.89e-12 65.1 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,1S24F@1236|Gammaproteobacteria,1XJAQ@135619|Oceanospirillales 135619|Oceanospirillales S Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_519893_1 1304885.AUEY01000020_gene3502 7.15e-76 239.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2MIAD@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_22766_1 1415778.JQMM01000001_gene2175 1.56e-209 588.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1J56Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits - - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_22766_2 472759.Nhal_2241 1.4e-21 87.8 COG0355@1|root,COG0355@2|Bacteria,1N1NE@1224|Proteobacteria,1S9B5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C epsilon subunit - - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_388027_1 1168034.FH5T_04000 2.47e-164 471.0 COG0260@1|root,COG0260@2|Bacteria,4NDWT@976|Bacteroidetes,2FMS1@200643|Bacteroidia 976|Bacteroidetes E Cytosol aminopeptidase family, catalytic domain pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_452712_1 588596.U9TDT2 1.16e-22 102.0 COG0095@1|root,KOG3159@2759|Eukaryota,38IBB@33154|Opisthokonta,3NTYI@4751|Fungi 4751|Fungi H Lipoate-protein ligase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:0140096,GO:1901564 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB,Lip_prot_lig_C k59_419006_1 555779.Dthio_PD0436 3.37e-19 89.4 COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,42Q61@68525|delta/epsilon subdivisions,2WM4W@28221|Deltaproteobacteria,2MG0J@213115|Desulfovibrionales 555779.Dthio_PD0436|- S Domain of unknown function (DUF4143) - - - - - - - - - - - - - k59_419006_2 324925.Ppha_1041 1.61e-20 89.7 COG5421@1|root,COG5421@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1 k59_22772_2 1047013.AQSP01000126_gene2727 2.5e-29 105.0 COG1278@1|root,COG1278@2|Bacteria,2NPXP@2323|unclassified Bacteria 2|Bacteria K 'Cold-shock' DNA-binding domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_355419_1 997350.HMPREF9129_0117 4.28e-38 144.0 COG3634@1|root,COG3634@2|Bacteria,1UIUB@1239|Firmicutes,25ES4@186801|Clostridia,22G2J@1570339|Peptoniphilaceae 186801|Clostridia C Alkyl hydroperoxide reductase, F subunit ahpF - - ko:K03387 - - - - ko00000,ko01000 - - - Glutaredoxin,Pyr_redox_2,Thioredoxin_3 k59_160334_1 929558.SMGD1_0890 3.87e-94 294.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2YMB2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_876809_1 1525715.IX54_12045 1.02e-103 324.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TSAP@28211|Alphaproteobacteria,2PVP8@265|Paracoccus 28211|Alphaproteobacteria C Molydopterin dinucleotide binding domain - - 1.7.2.3 ko:K07812,ko:K08351 ko00780,ko01100,map00780,map01100 - R10127 RC03056 ko00000,ko00001,ko01000,ko02000 5.A.3.4 - - Molybdopterin,Molydop_binding k59_519909_1 929558.SMGD1_0427 7.87e-97 301.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,42MUY@68525|delta/epsilon subdivisions,2YMZF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E PFAM peptidase M3A and M3B thimet oligopeptidase F prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_452732_1 555779.Dthio_PD3610 2.55e-36 127.0 2E0F6@1|root,32W1G@2|Bacteria,1N6I3@1224|Proteobacteria,42V01@68525|delta/epsilon subdivisions,2WQWS@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_975138_2 398720.MED217_11009 9.6e-31 122.0 COG0078@1|root,COG0078@2|Bacteria,4NEYX@976|Bacteroidetes,1HYDI@117743|Flavobacteriia,2XHW9@283735|Leeuwenhoekiella 976|Bacteroidetes E Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 ko:K09065,ko:K13043 ko00220,ko01100,ko01230,map00220,map01100,map01230 M00845 R07245,R08937 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_745208_1 1123501.KB902287_gene1965 4.44e-38 132.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2TRQH@28211|Alphaproteobacteria 28211|Alphaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_649247_1 1121405.dsmv_0616 1.4e-120 368.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,42NNE@68525|delta/epsilon subdivisions,2WJZX@28221|Deltaproteobacteria,2MI6X@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit qmoB - - ko:K16886 - - - - ko00000 - - - Fer4,Fer4_9,FlpD,Pyr_redox_2 k59_909785_1 1517416.IDAT_11075 8.41e-122 366.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,2QF9G@267893|Idiomarinaceae 1236|Gammaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_519916_1 644107.SL1157_A0191 1.08e-99 305.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1N3PN@1224|Proteobacteria,2U2TJ@28211|Alphaproteobacteria,4NBKA@97050|Ruegeria 28211|Alphaproteobacteria C Cytochrome D1 heme domain nirS GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_287770_1 768671.ThimaDRAFT_0176 1.82e-38 140.0 COG0392@1|root,COG0392@2|Bacteria,1R5YC@1224|Proteobacteria,1S815@1236|Gammaproteobacteria,1WX3Y@135613|Chromatiales 135613|Chromatiales S Lysylphosphatidylglycerol synthase TM region - - - - - - - - - - - - LPG_synthase_TM k59_714078_1 1165841.SULAR_04903 6.03e-134 383.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2YMZ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ABC transporter, ATP-binding protein lptB - - ko:K01990,ko:K06861 ko02010,map02010 M00254,M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1,3.A.1 - - ABC_tran,BCA_ABC_TP_C k59_551860_1 385682.AFSL01000026_gene645 1.82e-08 51.6 COG0089@1|root,COG0089@2|Bacteria,4NS7H@976|Bacteroidetes,2FT3A@200643|Bacteroidia,3XKBV@558415|Marinilabiliaceae 976|Bacteroidetes J Ribosomal protein L23 rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_551860_2 1168034.FH5T_12830 1.8e-181 506.0 COG0090@1|root,COG0090@2|Bacteria,4NE8G@976|Bacteroidetes,2FN89@200643|Bacteroidia 976|Bacteroidetes J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_551860_3 1168034.FH5T_12835 4.21e-31 110.0 COG0185@1|root,COG0185@2|Bacteria,4NQ8T@976|Bacteroidetes,2FT46@200643|Bacteroidia 976|Bacteroidetes J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_452753_1 748247.AZKH_2559 1.83e-101 300.0 COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2VHPA@28216|Betaproteobacteria,2KW94@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin k59_616620_1 713586.KB900536_gene1783 1.52e-39 150.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales 135613|Chromatiales M PFAM Lytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_808332_1 1168034.FH5T_14845 1.17e-38 132.0 COG0640@1|root,COG0640@2|Bacteria,4NQK3@976|Bacteroidetes,2FYHY@200643|Bacteroidia 976|Bacteroidetes K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 k59_160370_1 1168034.FH5T_18730 2.16e-96 309.0 COG0653@1|root,COG0653@2|Bacteria,4NF7C@976|Bacteroidetes,2FMVF@200643|Bacteroidia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1040686_1 1265502.KB905932_gene1797 3.79e-56 195.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,4ABBZ@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DUF3394,DctM k59_388079_2 768671.ThimaDRAFT_3553 1.37e-74 233.0 COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,1RSGM@1236|Gammaproteobacteria,1WXDR@135613|Chromatiales 135613|Chromatiales S Metal-dependent hydrolase, beta-lactamase superfamily II - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_192269_1 234267.Acid_2120 1.44e-46 175.0 COG1361@1|root,COG1361@2|Bacteria,3Y2G0@57723|Acidobacteria 57723|Acidobacteria M Alpha-L-arabinofuranosidase B, catalytic - - - - - - - - - - - - ArabFuran-catal,LTD,NPCBM_assoc k59_1040688_1 765912.Thimo_0132 1.19e-39 135.0 COG3118@1|root,COG3118@2|Bacteria,1RI6E@1224|Proteobacteria,1S8B4@1236|Gammaproteobacteria,1WYJW@135613|Chromatiales 135613|Chromatiales O Belongs to the thioredoxin family - - - ko:K05838 - - - - ko00000,ko03110 - - - Thioredoxin k59_388083_1 1123401.JHYQ01000005_gene234 6.78e-71 227.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria,463RQ@72273|Thiotrichales 72273|Thiotrichales P CorA-like Mg2+ transporter protein - - - - - - - - - - - - CorA k59_808335_1 396588.Tgr7_1016 6.83e-68 215.0 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria,1WWYH@135613|Chromatiales 135613|Chromatiales E Bacterial transglutaminase-like N-terminal - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_551880_1 1168034.FH5T_04430 2.41e-66 222.0 COG1082@1|root,COG1082@2|Bacteria,4NEWC@976|Bacteroidetes,2FKZT@200643|Bacteroidia 976|Bacteroidetes G alpha-glucosidase susB GO:0000272,GO:0003674,GO:0003824,GO:0004339,GO:0004553,GO:0004558,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015926,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:0090599,GO:1901575 3.2.1.20,3.2.1.3 ko:K01187,ko:K21574 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R01790,R01791,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31,GH97 - GH97_C,GH97_N,Glyco_hydro_97 k59_225410_1 1101192.KB910516_gene348 2.41e-92 291.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,1JTHV@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_877517_1 289377.HL41_03660 4.51e-27 111.0 COG0141@1|root,COG0141@2|Bacteria,2GHCX@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_419830_1 335543.Sfum_3617 9.01e-19 86.3 COG1842@1|root,COG1842@2|Bacteria,1Q6II@1224|Proteobacteria,43383@68525|delta/epsilon subdivisions,2WY57@28221|Deltaproteobacteria 28221|Deltaproteobacteria KT PFAM PspA IM30 family - - - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_584727_1 396588.Tgr7_1176 1.7e-204 602.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_59482_1 1168034.FH5T_09770 5.45e-95 285.0 COG2010@1|root,COG2010@2|Bacteria,4NV2A@976|Bacteroidetes,2FY82@200643|Bacteroidia 976|Bacteroidetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_257115_1 1182590.BN5_00507 4.17e-25 110.0 COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1YD18@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_484916_1 1537917.JU82_03315 1.53e-129 378.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2YMCI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_745977_1 1168034.FH5T_02000 3.91e-21 92.4 COG2942@1|root,COG2942@2|Bacteria,4NEH7@976|Bacteroidetes,2FM9N@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) bfce - 5.1.3.11 ko:K16213 - - R01445,R10810 RC00289 ko00000,ko01000 - - - GlcNAc_2-epim k59_745977_2 1168034.FH5T_03525 6.67e-31 120.0 COG3307@1|root,COG3307@2|Bacteria,4NMYT@976|Bacteroidetes 976|Bacteroidetes M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_584734_1 886293.Sinac_0967 1.61e-58 204.0 COG0841@1|root,COG0841@2|Bacteria,2IX3P@203682|Planctomycetes 203682|Planctomycetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1024943_29 765913.ThidrDRAFT_0127 6.53e-47 155.0 COG2105@1|root,COG2105@2|Bacteria,1RH3X@1224|Proteobacteria,1S68T@1236|Gammaproteobacteria,1WYAJ@135613|Chromatiales 135613|Chromatiales S PFAM AIG2-like - - - - - - - - - - - - GGACT k59_1024943_30 1188256.BASI01000005_gene1625 7.08e-26 99.4 COG3383@1|root,COG3383@2|Bacteria,1QU53@1224|Proteobacteria,2U9QC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Ferredoxin fdxB - - - - - - - - - - - Fer4,Fer4_10,Fer4_4,Fer4_7 k59_1024943_31 870187.Thini_4021 1.59e-74 226.0 2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,1S5CH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Nitrogen fixation protein - - - - - - - - - - - - DUF269 k59_1024943_32 870187.Thini_4019 2.17e-48 161.0 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,1S50W@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pfam Dinitrogenase iron-molybdenum cofactor nifX - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_1024943_33 572477.Alvin_0904 1.64e-219 619.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,1RPBI@1236|Gammaproteobacteria,1WWZJ@135613|Chromatiales 135613|Chromatiales C Belongs to the NifD NifK NifE NifN family - - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_1024943_34 765913.ThidrDRAFT_2759 1.96e-283 782.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,1RQ8X@1236|Gammaproteobacteria,1WW6F@135613|Chromatiales 135613|Chromatiales C Belongs to the NifD NifK NifE NifN family - - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_1024943_35 1304885.AUEY01000004_gene978 6.74e-156 449.0 28IWG@1|root,2Z8US@2|Bacteria,1NHDW@1224|Proteobacteria,42MHT@68525|delta/epsilon subdivisions,2WMMN@28221|Deltaproteobacteria,2MMHW@213118|Desulfobacterales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157 k59_730441_1 1537917.JU82_03270 5.31e-72 221.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,42MG4@68525|delta/epsilon subdivisions,2YME4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K response regulator cprR - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_829379_1 1160707.AJIK01000003_gene641 2.43e-97 296.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4HA5K@91061|Bacilli,26CW9@186818|Planococcaceae 91061|Bacilli E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_404210_1 1198452.Jab_2c01960 5.12e-40 147.0 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,2WGKB@28216|Betaproteobacteria,476H4@75682|Oxalobacteraceae 28216|Betaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_110616_9 425104.Ssed_0869 5.45e-24 107.0 COG2197@1|root,COG2197@2|Bacteria,1NPE8@1224|Proteobacteria,1RPXE@1236|Gammaproteobacteria,2QDMM@267890|Shewanellaceae 1236|Gammaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_110616_10 1196835.A458_14595 7.12e-96 285.0 COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,1RRV0@1236|Gammaproteobacteria,1Z02J@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Integrase - - - - - - - - - - - - Phage_integrase k59_110616_14 76869.PputGB1_4162 3.12e-25 96.3 2DND7@1|root,32WWM@2|Bacteria,1N9KM@1224|Proteobacteria 1224|Proteobacteria S Uncharacterized protein conserved in bacteria (DUF2188) - - - - - - - - - - - - DUF2188 k59_666889_1 1168034.FH5T_18520 5.36e-152 433.0 COG0552@1|root,COG0552@2|Bacteria,4NE9Z@976|Bacteroidetes,2FMMT@200643|Bacteroidia 976|Bacteroidetes U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_730448_1 1511.CLOST_0074 1.27e-70 226.0 COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,24DV7@186801|Clostridia 186801|Clostridia P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_340409_1 290512.Paes_2372 7.7e-25 107.0 COG0641@1|root,COG0641@2|Bacteria,1FEDJ@1090|Chlorobi 1090|Chlorobi C PFAM Radical SAM domain protein - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM k59_436402_1 1232683.ADIMK_0558 4.11e-56 188.0 COG2334@1|root,COG2334@2|Bacteria,1PGM7@1224|Proteobacteria,1RNPA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S homoserine kinase type II (Protein kinase fold) - - - - - - - - - - - - APH k59_928252_2 1120968.AUBX01000010_gene1262 3.6e-16 80.9 COG3193@1|root,COG3193@2|Bacteria,4NGRH@976|Bacteroidetes,47Q7C@768503|Cytophagia 976|Bacteroidetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_829388_1 572544.Ilyop_1688 8.72e-74 247.0 COG1452@1|root,COG1452@2|Bacteria,37983@32066|Fusobacteria 32066|Fusobacteria M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - k59_633874_1 1347086.CCBA010000008_gene1267 8.13e-11 68.2 COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1TPKU@1239|Firmicutes,4H9KR@91061|Bacilli,1ZAVB@1386|Bacillus 91061|Bacilli GT COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) fruA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563 2.7.1.202 ko:K02768,ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB k59_176553_2 1249480.B649_05440 3.36e-98 288.0 COG0745@1|root,COG0745@2|Bacteria,1Q4AG@1224|Proteobacteria,42YR3@68525|delta/epsilon subdivisions,2YR20@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Response regulator receiver - - - - - - - - - - - - Response_reg k59_305543_1 457570.Nther_0365 6.49e-34 130.0 COG3587@1|root,COG3587@2|Bacteria,1TPRR@1239|Firmicutes,2488I@186801|Clostridia 186801|Clostridia L Type III restriction - - 3.1.21.5 ko:K01156 - - - - ko00000,ko01000,ko02048 - - - ResIII k59_272955_2 1168034.FH5T_12720 7.46e-75 239.0 COG0155@1|root,COG0155@2|Bacteria,4NENW@976|Bacteroidetes,2FRKX@200643|Bacteroidia 976|Bacteroidetes P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate cysI - 1.7.7.1,1.8.1.2 ko:K00366,ko:K00381 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00858 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_177205_1 1168034.FH5T_01750 5.19e-14 71.2 COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,2FPVW@200643|Bacteroidia 976|Bacteroidetes G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Fucosidase_C k59_994018_3 387093.SUN_0512 2.3e-61 202.0 COG1143@1|root,COG1145@1|root,COG1143@2|Bacteria,COG1145@2|Bacteria,1N7HT@1224|Proteobacteria,42RFF@68525|delta/epsilon subdivisions,2YP9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 k59_764358_1 909663.KI867150_gene490 1.3e-83 262.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria,2MQ4E@213462|Syntrophobacterales 28221|Deltaproteobacteria S Vacuole effluxer Atg22 like - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_209689_1 247633.GP2143_01865 5.42e-38 147.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,1J8TD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_241512_1 754477.Q7C_2373 4.95e-115 348.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,45ZT8@72273|Thiotrichales 72273|Thiotrichales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_341088_1 426114.THI_2276 2.6e-21 91.3 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,1KN0I@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Transcriptional regulatory protein, C terminal - - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_341088_2 314287.GB2207_11193 2.88e-05 49.3 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,1RPG9@1236|Gammaproteobacteria,1J4EW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain qseC - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_111190_1 177437.HRM2_07710 1.12e-123 357.0 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,42R8M@68525|delta/epsilon subdivisions,2WMSA@28221|Deltaproteobacteria,2MHX1@213118|Desulfobacterales 28221|Deltaproteobacteria M Asp/Glu/Hydantoin racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_241514_1 1123269.NX02_21130 7.79e-32 120.0 2DN0U@1|root,32UTB@2|Bacteria,1MZ2J@1224|Proteobacteria,2UHAI@28211|Alphaproteobacteria,2K24S@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_241514_2 1163408.UU9_10282 3.29e-15 75.5 COG3735@1|root,COG3735@2|Bacteria,1NARA@1224|Proteobacteria,1T12Y@1236|Gammaproteobacteria,1X4VR@135614|Xanthomonadales 135614|Xanthomonadales S TraB family gumN - - - - - - - - - - - TraB k59_830002_2 1168034.FH5T_17225 5.76e-89 276.0 COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,2FMMH@200643|Bacteroidia 976|Bacteroidetes H acetolactate synthase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_862155_1 1049564.TevJSym_ap00430 2.22e-79 245.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1J4X5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_764367_2 469616.FMAG_01302 6e-87 265.0 COG0564@1|root,COG0564@2|Bacteria,37A6R@32066|Fusobacteria 32066|Fusobacteria J Belongs to the pseudouridine synthase RluA family - - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_111195_1 335283.Neut_1045 7.87e-17 78.2 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2VR8K@28216|Betaproteobacteria,372ZV@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_144887_1 929558.SMGD1_0381 1.02e-45 150.0 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,42SAC@68525|delta/epsilon subdivisions 1224|Proteobacteria T PFAM response regulator receiver cheY34H-1 - 2.7.13.3 ko:K03407,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - Response_reg k59_144887_2 929558.SMGD1_0382 4.37e-130 377.0 COG1352@1|root,COG1352@2|Bacteria,1MVP3@1224|Proteobacteria,42SZX@68525|delta/epsilon subdivisions,2YTRV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Methyltransferase, chemotaxis proteins - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR k59_144887_3 929558.SMGD1_0383 1.76e-27 105.0 COG1413@1|root,COG1413@2|Bacteria,1RIZR@1224|Proteobacteria 1224|Proteobacteria C HEAT repeats - - - - - - - - - - - - HEAT_2 k59_794410_1 438753.AZC_2938 4.83e-94 296.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3F0QB@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_601874_1 886379.AEWI01000122_gene1876 1.15e-28 111.0 COG0664@1|root,COG0664@2|Bacteria,4P3ES@976|Bacteroidetes,2FYTV@200643|Bacteroidia,3XKZ8@558415|Marinilabiliaceae 976|Bacteroidetes T Cyclic nucleotide-monophosphate binding domain - - - ko:K21562 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_731032_1 330214.NIDE1309 1.04e-128 376.0 COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae 40117|Nitrospirae J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis - - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_830008_1 368407.Memar_2489 1.08e-71 235.0 COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N913@224756|Methanomicrobia 224756|Methanomicrobia P Ferrous iron transport B domain protein - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_764377_1 987059.RBXJA2T_15588 1.77e-23 105.0 COG0642@1|root,COG0834@1|root,COG2461@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KJCZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - 4HB_MCP_1,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_504536_2 76114.ebA2245 1.62e-84 264.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,2KVQ1@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_241528_2 1485544.JQKP01000004_gene537 4.29e-19 87.8 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2VMB7@28216|Betaproteobacteria 28216|Betaproteobacteria C Major Facilitator - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC k59_404860_1 1026882.MAMP_00712 3.44e-104 323.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,45ZU0@72273|Thiotrichales 72273|Thiotrichales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_536833_1 742767.HMPREF9456_01214 3.42e-18 85.5 COG1595@1|root,COG1595@2|Bacteria,4NSVA@976|Bacteroidetes,2FMT6@200643|Bacteroidia,22Y4K@171551|Porphyromonadaceae 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_764381_1 1123393.KB891328_gene696 2.31e-63 201.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,1KT8R@119069|Hydrogenophilales 119069|Hydrogenophilales G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_764381_2 1123393.KB891328_gene695 4.94e-39 135.0 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VQTE@28216|Betaproteobacteria,1KTCZ@119069|Hydrogenophilales 119069|Hydrogenophilales G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_341111_1 1319815.HMPREF0202_02668 1.38e-31 119.0 COG0115@1|root,COG0115@2|Bacteria,378G4@32066|Fusobacteria 32066|Fusobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_341111_2 1286171.EAL2_c15540 2.76e-101 313.0 COG3855@1|root,COG3855@2|Bacteria,1TPFU@1239|Firmicutes,248ZC@186801|Clostridia,25VED@186806|Eubacteriaceae 186801|Clostridia G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 fbp - 3.1.3.11 ko:K04041 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_2 k59_78332_2 159450.NH14_23620 1.1e-28 108.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2VQC5@28216|Betaproteobacteria,1K1V9@119060|Burkholderiaceae 28216|Betaproteobacteria L Pfam Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_504545_1 762903.Pedsa_0479 2.33e-48 174.0 COG1554@1|root,COG1554@2|Bacteria,4NHVP@976|Bacteroidetes,1IPI9@117747|Sphingobacteriia 976|Bacteroidetes G hydrolase, family 65, central catalytic - - - - - - - - - - - - - k59_634593_1 1537917.JU82_05115 7.74e-89 277.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2YMTY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Mg chelatase-related protein comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_404872_1 1144319.PMI16_05014 2.15e-61 204.0 COG1788@1|root,COG1788@2|Bacteria,1R1R7@1224|Proteobacteria,2WI4N@28216|Betaproteobacteria,4727J@75682|Oxalobacteraceae 28216|Betaproteobacteria I malonate decarboxylase, alpha subunit mdcA - 2.3.1.187 ko:K13929 - - R08944 RC00012,RC00014 ko00000,ko01000,ko02000 3.B.1.1.4 - - Mal_decarbox_Al k59_404872_2 1007105.PT7_0163 2.08e-08 54.7 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VJME@28216|Betaproteobacteria,3T6HX@506|Alcaligenaceae 28216|Betaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_895612_1 1049564.TevJSym_aa01270 1.19e-92 278.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,1RMJ2@1236|Gammaproteobacteria,1J4WA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Belongs to the flagella basal body rod proteins family flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_568986_1 485915.Dret_1201 5.69e-123 367.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2M7VS@213115|Desulfovibrionales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,PAS_9,Sigma54_activat k59_144912_1 1168034.FH5T_01410 7.17e-40 133.0 2EFPT@1|root,339FT@2|Bacteria,4NV1V@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_144912_2 1144313.PMI10_03697 6.94e-15 72.8 COG1595@1|root,COG1595@2|Bacteria,4NSVA@976|Bacteroidetes,1I0Q1@117743|Flavobacteriia,2NS8W@237|Flavobacterium 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_504563_1 387093.SUN_2269 1.68e-91 275.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2YMQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_634603_1 1168034.FH5T_17935 1.98e-63 197.0 COG4747@1|root,COG4747@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - ACT k59_634603_2 1121098.HMPREF1534_02148 4.99e-18 86.3 292UM@1|root,2ZQC9@2|Bacteria,4NTGF@976|Bacteroidetes,2FMY7@200643|Bacteroidia,4ANUN@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_601908_1 986075.CathTA2_0945 1.24e-65 213.0 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,4HBJ6@91061|Bacilli 91061|Bacilli J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA GO:0002097,GO:0002098,GO:0002143,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_437044_1 1165841.SULAR_08332 5.57e-103 305.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,42ME8@68525|delta/epsilon subdivisions,2YN4W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_404884_2 1317124.DW2_18923 1.6e-95 282.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2U0PH@28211|Alphaproteobacteria,2XP68@285107|Thioclava 28211|Alphaproteobacteria L IstB-like ATP binding N-terminal - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_470148_2 1537917.JU82_07640 1.99e-113 338.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,42M78@68525|delta/epsilon subdivisions,2YMR1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_769924_1 349124.Hhal_1210 4.17e-73 235.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVW7@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_510068_1 335284.Pcryo_2501 2.39e-46 159.0 COG3769@1|root,COG3769@2|Bacteria,1NFV5@1224|Proteobacteria,1RR9R@1236|Gammaproteobacteria,3NPWQ@468|Moraxellaceae 1236|Gammaproteobacteria S Sucrose-6F-phosphate phosphohydrolase yedP - 2.7.1.31,3.1.3.70 ko:K07026,ko:K15918 ko00051,ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00051,map00260,map00561,map00630,map01100,map01110,map01130,map01200 M00532 R01514,R05790 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Hydrolase_3,S6PP k59_510068_2 880073.Calab_2576 8.17e-37 140.0 COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria 2|Bacteria G MOFRL family ttuD - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_835346_1 864051.BurJ1DRAFT_2239 1.31e-07 58.2 COG1361@1|root,COG2304@1|root,COG2931@1|root,COG2982@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,1KK67@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q TIGRFAM outer membrane adhesin like proteiin - - - - - - - - - - - - Cadherin_3,DUF4347,He_PIG,HemolysinCabind,VWA_2 k59_704736_2 1168034.FH5T_03025 4.61e-76 237.0 COG0763@1|root,COG0763@2|Bacteria,4NDW3@976|Bacteroidetes,2FPE5@200643|Bacteroidia 976|Bacteroidetes M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_377848_1 335543.Sfum_1739 1.51e-25 104.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,42M9K@68525|delta/epsilon subdivisions,2WJ22@28221|Deltaproteobacteria,2MR2H@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,Aminotran_1_2,CbiA,GATase_3,TP_methylase k59_377848_2 1449063.JMLS01000023_gene2878 1.07e-40 152.0 COG0079@1|root,COG1492@1|root,COG0079@2|Bacteria,COG1492@2|Bacteria,1TP5E@1239|Firmicutes,4HAQW@91061|Bacilli,26UJH@186822|Paenibacillaceae 91061|Bacilli H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_116471_1 604331.AUHY01000048_gene2130 1.83e-16 79.0 COG0517@1|root,COG0517@2|Bacteria,1WMQJ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Domain in cystathionine beta-synthase and other proteins. - - - ko:K04767 - - - - ko00000 - - - CBS k59_116474_1 342113.DM82_6343 3.07e-74 237.0 COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,2W26D@28216|Betaproteobacteria,1KADQ@119060|Burkholderiaceae 28216|Betaproteobacteria E to Mus musculus sphingosine-1-phosphate lyase Sgpl1 SWALL O54955 (EMBL AF036894) (568 aa) fasta scores E() - - 4.1.2.27 ko:K01634 ko00600,ko01100,ko04071,map00600,map01100,map04071 M00100 R02464,R06516 RC00264,RC00721,RC01266 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_311622_1 1168034.FH5T_20355 5.85e-124 374.0 COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes 976|Bacteroidetes E Aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_999457_1 998674.ATTE01000001_gene4066 9.31e-56 186.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,460M1@72273|Thiotrichales 72273|Thiotrichales P Required for the activity of the bacterial periplasmic transport system of putrescine potF - - ko:K11073 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - SBP_bac_8 k59_215248_2 525898.Sdel_1670 1.29e-57 191.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2YM8W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_966190_2 765911.Thivi_4504 2.68e-45 154.0 COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria,1WXXG@135613|Chromatiales 135613|Chromatiales L PFAM HhH-GPD - - - ko:K07457 - - - - ko00000 - - - HhH-GPD k59_510078_1 2340.JV46_08030 7.04e-143 411.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1JA5H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K LysR substrate binding domain oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_410227_1 991905.SL003B_0150 3.25e-97 316.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,4BPMR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Bacterial NAD-glutamate dehydrogenase gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_116485_1 1249480.B649_03720 1.44e-66 219.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,42T05@68525|delta/epsilon subdivisions 1224|Proteobacteria S Protein kinase, ABC1 domain-containing - - - - - - - - - - - - ABC1,APH k59_182771_1 1168034.FH5T_18420 4.39e-70 225.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,2FM4G@200643|Bacteroidia 976|Bacteroidetes I Carboxyl transferase domain protein mmdA - - - - - - - - - - - Carboxyl_trans k59_182771_2 1168034.FH5T_18415 1.07e-42 143.0 COG3630@1|root,COG3630@2|Bacteria,4NV8J@976|Bacteroidetes,2G2DV@200643|Bacteroidia 976|Bacteroidetes C COG NOG19100 non supervised orthologous group - - - - - - - - - - - - LTD,OAD_gamma k59_639895_1 1149133.ppKF707_0501 2.28e-07 50.4 2DRB5@1|root,33B20@2|Bacteria,1NIFF@1224|Proteobacteria,1SGF4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative addiction module component - - - - - - - - - - - - Unstab_antitox k59_639895_2 214092.YPO3612 4.32e-36 127.0 COG1396@1|root,COG1396@2|Bacteria,1RF9G@1224|Proteobacteria,1S5F5@1236|Gammaproteobacteria,41GPT@629|Yersinia 1236|Gammaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_3 k59_769952_1 1122201.AUAZ01000021_gene3194 2.96e-66 215.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,464MZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_49049_1 1165841.SULAR_07735 1.16e-30 122.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2YNP4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_1030844_1 414684.RC1_1457 1.45e-87 265.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2TRRJ@28211|Alphaproteobacteria,2JQ7X@204441|Rhodospirillales 204441|Rhodospirillales E COG1177 ABC-type spermidine putrescine transport system, permease component II potI - - ko:K11074 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_311635_1 627192.SLG_01570 4.29e-85 271.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2K0PZ@204457|Sphingomonadales 204457|Sphingomonadales E gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_311636_1 926556.Echvi_4497 6.83e-75 236.0 COG3677@1|root,COG3677@2|Bacteria,4NHYS@976|Bacteroidetes,47QNY@768503|Cytophagia 976|Bacteroidetes L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_13064_1 749222.Nitsa_0482 1.16e-180 538.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2YMTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_639927_1 1217720.ALOX01000032_gene253 5.34e-19 84.0 COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,2JTDG@204441|Rhodospirillales 204441|Rhodospirillales C COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_999479_1 1260251.SPISAL_02640 3.11e-25 105.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1WWGT@135613|Chromatiales 135613|Chromatiales S Permease YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_999479_2 522306.CAP2UW1_4127 5.72e-36 139.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,1KPNZ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_83500_1 313606.M23134_06215 2.66e-134 405.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia 976|Bacteroidetes G PFAM Glycosyl Hydrolase - - - - - - - - - - - - Glyco_hydro_92 k59_116509_1 1283300.ATXB01000001_gene1784 8.42e-45 157.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1XDJA@135618|Methylococcales 135618|Methylococcales S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_150182_1 398720.MED217_11059 7.15e-11 62.0 COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,1HXF9@117743|Flavobacteriia,2XJ10@283735|Leeuwenhoekiella 976|Bacteroidetes EH Thiamine pyrophosphate enzyme, central domain ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_150182_2 1168034.FH5T_17220 2.22e-60 190.0 COG0440@1|root,COG0440@2|Bacteria,4NIDK@976|Bacteroidetes,2FNQ4@200643|Bacteroidia 976|Bacteroidetes E synthase small subunit ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_442296_1 388413.ALPR1_02185 2.71e-108 345.0 COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes 2|Bacteria T Histidine kinase - - - - - - - - - - - - CHASE2,HATPase_c,HisKA,Reg_prop,SnoaL_3,Y_Y_Y k59_1030877_1 1121403.AUCV01000033_gene3626 1.96e-43 162.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,42MZC@68525|delta/epsilon subdivisions,2WKRK@28221|Deltaproteobacteria,2MIYS@213118|Desulfobacterales 28221|Deltaproteobacteria C Protein of unknown function (DUF3683) - - - - - - - - - - - - CCG,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_10,Fer4_8 k59_542047_2 32042.PstZobell_04861 3.33e-159 470.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1Z1E2@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria U Belongs to the BCCT transporter (TC 2.A.15) family betT - - ko:K02168 - - - - ko00000,ko02000 2.A.15.1.3,2.A.15.1.4 - - BCCT k59_639943_1 1283299.AUKG01000001_gene3517 1.03e-08 62.0 COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,2GS3I@201174|Actinobacteria 201174|Actinobacteria T protein phosphatase 2C domain protein prpG2 - - - - - - - - - - - Response_reg,SpoIIE k59_607365_1 1123253.AUBD01000009_gene2225 1.37e-59 201.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1X3CQ@135614|Xanthomonadales 135614|Xanthomonadales E Transporter yhiP - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_736270_1 1168034.FH5T_08945 6.3e-93 280.0 COG0332@1|root,COG0332@2|Bacteria,4NEYH@976|Bacteroidetes,2FM5X@200643|Bacteroidia 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_1030883_1 1321778.HMPREF1982_01131 4.23e-15 74.3 COG0561@1|root,COG0561@2|Bacteria,1TR16@1239|Firmicutes,248MW@186801|Clostridia,26CPG@186813|unclassified Clostridiales 186801|Clostridia S Sucrose-6F-phosphate phosphohydrolase - - - - - - - - - - - - Hydrolase_3 k59_1030883_2 556263.FSEG_00859 2.74e-40 134.0 COG0184@1|root,COG0184@2|Bacteria,37APE@32066|Fusobacteria 32066|Fusobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_278175_1 882.DVU_1781 3.14e-61 197.0 COG1556@1|root,COG1556@2|Bacteria,1RJ6A@1224|Proteobacteria,42VHI@68525|delta/epsilon subdivisions,2WSAQ@28221|Deltaproteobacteria,2MC7E@213115|Desulfovibrionales 28221|Deltaproteobacteria S Pfam:DUF162 - - - ko:K00782 - - - - ko00000 - - - LUD_dom k59_900809_1 1121441.AUCX01000009_gene2422 7.41e-84 260.0 COG0444@1|root,COG0444@2|Bacteria,1QWV4@1224|Proteobacteria,42ZHH@68525|delta/epsilon subdivisions,2WUUQ@28221|Deltaproteobacteria,2MA4F@213115|Desulfovibrionales 28221|Deltaproteobacteria EP ATPases associated with a variety of cellular activities - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_673069_1 572544.Ilyop_1854 3.28e-103 311.0 COG0773@1|root,COG0773@2|Bacteria,3788J@32066|Fusobacteria 32066|Fusobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_999505_1 1168034.FH5T_06680 8.74e-102 302.0 COG0685@1|root,COG0685@2|Bacteria,4NDY0@976|Bacteroidetes,2FMPC@200643|Bacteroidia 976|Bacteroidetes C Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_346609_1 631362.Thi970DRAFT_03536 3.68e-137 423.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_442320_2 870967.VIS19158_10309 5.35e-71 214.0 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,1S6DA@1236|Gammaproteobacteria 1236|Gammaproteobacteria L IS66 Orf2 like - - - - - - - - - - - - TnpB_IS66 k59_377901_1 59689.fgenesh1_pm.C_scaffold_2000554 1.5e-153 450.0 28JJ8@1|root,2QRYE@2759|Eukaryota,37QY5@33090|Viridiplantae,3GH5Y@35493|Streptophyta,3I1XS@3699|Brassicales 35493|Streptophyta C PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin psaB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009941,GO:0010287,GO:0016020,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 - ko:K02690 ko00195,ko01100,map00195,map01100 M00163 - - ko00000,ko00001,ko00002,ko00194 - - - PsaA_PsaB k59_377901_2 4155.Migut.J01359.1.p 6.4e-37 125.0 COG0199@1|root,KOG1741@2759|Eukaryota,37VQM@33090|Viridiplantae,3GJZT@35493|Streptophyta 35493|Streptophyta J Binds 16S rRNA, required for the assembly of 30S particles rps14 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_13103_1 886379.AEWI01000210_gene2485 6.04e-20 88.2 COG2152@1|root,COG2152@2|Bacteria,4NGA2@976|Bacteroidetes,2FMJR@200643|Bacteroidia,3XJSF@558415|Marinilabiliaceae 976|Bacteroidetes G beta-1,4-mannooligosaccharide phosphorylase - - 2.4.1.281 ko:K16212 - - R09943 RC00049 ko00000,ko01000 - - - Glyco_hydro_130 k59_13103_2 1168034.FH5T_17620 3.08e-82 253.0 COG0673@1|root,COG0673@2|Bacteria,4NE07@976|Bacteroidetes,2FNUN@200643|Bacteroidia 976|Bacteroidetes H Oxidoreductase NAD-binding domain protein - - - - - - - - - - - - GFO_IDH_MocA k59_346617_1 1026882.MAMP_00247 4.77e-72 232.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,45ZP9@72273|Thiotrichales 72273|Thiotrichales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_639951_1 491915.Aflv_2452 5.78e-37 149.0 COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,4HCUT@91061|Bacilli 91061|Bacilli L PFAM Integrase catalytic - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_673084_1 1537917.JU82_00520 8.46e-126 374.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2YMDG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD k59_49117_2 643648.Slip_2048 1.01e-26 105.0 COG0622@1|root,COG0622@2|Bacteria,1VA0U@1239|Firmicutes,24MMK@186801|Clostridia,42K6X@68298|Syntrophomonadaceae 186801|Clostridia S Calcineurin-like phosphoesterase superfamily domain yfcE1 - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_49117_3 1123405.AUMM01000005_gene853 2.58e-06 49.7 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,4HAVN@91061|Bacilli,26NEY@186821|Sporolactobacillaceae 91061|Bacilli J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_934066_1 1262449.CP6013_0234 1.13e-21 94.0 COG2849@1|root,COG2849@2|Bacteria,1V5HE@1239|Firmicutes,24AYV@186801|Clostridia,36FJG@31979|Clostridiaceae 186801|Clostridia S repeat protein - - - - - - - - - - - - - k59_247476_1 450851.PHZ_c1698 5.62e-75 243.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,2KJRT@204458|Caulobacterales 28211|Alphaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster MA20_01050 - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_770540_1 1165841.SULAR_03103 3.47e-260 723.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,42N0P@68525|delta/epsilon subdivisions,2YN14@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C UPF0313 protein - - - - - - - - - - - - Radical_SAM,Radical_SAM_N k59_799814_1 1049564.TevJSym_az00130 5.13e-199 560.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1J5AS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_799814_2 547144.HydHO_1377 2e-15 72.0 COG3411@1|root,COG3411@2|Bacteria,2G541@200783|Aquificae 200783|Aquificae C Ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx k59_799814_3 156889.Mmc1_1749 3.32e-311 860.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_799814_4 156889.Mmc1_1750 1.68e-158 450.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit MA20_01040 - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_799814_6 1121033.AUCF01000010_gene4534 7.79e-252 715.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,2JW5J@204441|Rhodospirillales 204441|Rhodospirillales C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Pyr_redox_2 k59_799814_7 697282.Mettu_3023 3.95e-52 166.0 COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,1S9G3@1236|Gammaproteobacteria,1XFBE@135618|Methylococcales 135618|Methylococcales S Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions ppnP - 2.4.2.1,2.4.2.2 ko:K09913 ko00230,ko00240,map00230,map00240 - R01561,R01570,R01863,R01876,R02147,R02296,R02297 RC00063,RC00122 ko00000,ko00001,ko01000 - - - DUF1255 k59_799814_8 298386.PBPRA1449 5.6e-64 207.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S6JM@1236|Gammaproteobacteria,1Y0FQ@135623|Vibrionales 135623|Vibrionales S Alpha/beta hydrolase family - - - ko:K06889 - - - - ko00000 - - - - k59_799814_9 1049564.TevJSym_ab00860 9.88e-44 145.0 COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,1S3Z2@1236|Gammaproteobacteria,1J6KI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acyl-CoA hydrolase - - - - - - - - - - - - 4HBT k59_799814_12 331678.Cphamn1_0473 0.0 1226.0 COG0493@1|root,COG0493@2|Bacteria,1FEHZ@1090|Chlorobi 2|Bacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - FeS,Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2,Pyr_redox_3 k59_799814_13 237368.SCABRO_03174 0.0 878.0 COG1894@1|root,COG1894@2|Bacteria,2IXJ8@203682|Planctomycetes 203682|Planctomycetes C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_799814_14 331678.Cphamn1_0471 4.05e-83 251.0 COG1905@1|root,COG1905@2|Bacteria 2|Bacteria C 2 iron, 2 sulfur cluster binding - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_799814_15 1163617.SCD_n02228 0.0 1602.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1MVM0@1224|Proteobacteria,2VN9C@28216|Betaproteobacteria 28216|Betaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_13,Fer4_16,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_799814_16 316067.Geob_3718 2.67e-142 408.0 COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,43UVP@69541|Desulfuromonadales 28221|Deltaproteobacteria C PFAM oxidoreductase FAD NAD(P)-binding domain protein hdrF - - - - - - - - - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_799814_17 237368.SCABRO_01874 1.62e-82 261.0 COG0479@1|root,COG0479@2|Bacteria,2IWTB@203682|Planctomycetes 203682|Planctomycetes C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_799814_18 526222.Desal_0598 3.99e-60 201.0 COG0479@1|root,COG1035@1|root,COG0479@2|Bacteria,COG1035@2|Bacteria,1NQN7@1224|Proteobacteria,42MGI@68525|delta/epsilon subdivisions,2WKNC@28221|Deltaproteobacteria,2M7U2@213115|Desulfovibrionales 28221|Deltaproteobacteria C Coenzyme F420 hydrogenase dehydrogenase, beta subunit hdrD - - - - - - - - - - - Fer4_10,Fer4_17,Fer4_8,FlpD,FrhB_FdhB_C k59_799814_19 194439.CT1247 5.14e-58 184.0 COG1908@1|root,COG1908@2|Bacteria,1FEFC@1090|Chlorobi 1090|Chlorobi C PFAM methyl-viologen-reducing hydrogenase delta subunit - - - - - - - - - - - - FlpD k59_799814_20 411476.BACOVA_05242 1.7e-289 813.0 COG1148@1|root,COG1148@2|Bacteria,4NI95@976|Bacteroidetes,2FRRV@200643|Bacteroidia,4ANZK@815|Bacteroidaceae 976|Bacteroidetes C Glucose inhibited division protein A - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Fer4,Fer4_7,HI0933_like,Pyr_redox_2 k59_799814_21 1125863.JAFN01000001_gene1774 2.46e-263 737.0 COG1053@1|root,COG1053@2|Bacteria,1R478@1224|Proteobacteria,42PCT@68525|delta/epsilon subdivisions,2WJIG@28221|Deltaproteobacteria 28221|Deltaproteobacteria C FAD binding domain - - 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00278 ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00115,M00149,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_644851_2 1123057.P872_02000 1.07e-29 119.0 COG4409@1|root,COG4409@2|Bacteria,4NI5M@976|Bacteroidetes,47JYZ@768503|Cytophagia 976|Bacteroidetes G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - BNR_2 k59_53995_1 641112.ACOK01000116_gene2690 2.81e-06 50.8 COG1896@1|root,COG1896@2|Bacteria,1TQ4N@1239|Firmicutes,24HCK@186801|Clostridia,3WGZW@541000|Ruminococcaceae 186801|Clostridia S HD domain - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_612277_1 2340.JV46_15900 3.99e-57 196.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1J9M8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - iSSON_1240.SSON_0092 PBP_dimer,Transpeptidase k59_316486_1 251229.Chro_1292 3.64e-40 141.0 COG3124@1|root,COG3124@2|Bacteria,1GKY3@1117|Cyanobacteria,3VMTC@52604|Pleurocapsales 1117|Cyanobacteria S Pfam:DUF479 - - - - - - - - - - - - ACP_PD k59_741183_1 96561.Dole_0237 1.24e-102 325.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2MIQM@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_382698_1 765911.Thivi_2349 9.34e-76 232.0 COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1WWWB@135613|Chromatiales 135613|Chromatiales O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_53998_1 1123487.KB892857_gene2355 3.79e-17 84.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VRSM@28216|Betaproteobacteria,2KVQV@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_840352_2 1249627.D779_3075 2.14e-11 63.5 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1WW2C@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_515136_3 1249627.D779_3573 1.07e-85 267.0 COG3267@1|root,COG3267@2|Bacteria,1R94V@1224|Proteobacteria,1T53H@1236|Gammaproteobacteria,1X2WM@135613|Chromatiales 1236|Gammaproteobacteria U Type II secretory pathway component ExeA - - - - - - - - - - - - AAA_16 k59_351441_1 1124780.ANNU01000010_gene3689 1.02e-31 128.0 COG0475@1|root,COG0475@2|Bacteria,4NF11@976|Bacteroidetes,47KD1@768503|Cytophagia 976|Bacteroidetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger,Usp k59_644855_1 929558.SMGD1_0766 3.06e-47 162.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,42NNZ@68525|delta/epsilon subdivisions,2YNIC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Peptidase dimerisation domain - - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_644855_2 563040.Saut_1755 3.1e-46 150.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,42TMU@68525|delta/epsilon subdivisions,2YPEI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_515140_1 234267.Acid_2075 8.09e-39 144.0 COG3356@1|root,COG3356@2|Bacteria,3Y5I7@57723|Acidobacteria 57723|Acidobacteria S Neutral/alkaline non-lysosomal ceramidase, N-terminal - - - - - - - - - - - - Ceramidase_alk k59_220202_1 1121105.ATXL01000017_gene1587 1.16e-17 85.5 COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,4HAKE@91061|Bacilli,4B0RK@81852|Enterococcaceae 91061|Bacilli M tail specific protease ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,PG_binding_1,Peptidase_S41 k59_220202_2 515635.Dtur_1359 4.63e-13 69.7 COG0359@1|root,COG0359@2|Bacteria 2|Bacteria J rRNA binding rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_220202_3 983920.Y88_2557 1.62e-24 95.1 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,2K60H@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_220202_6 225117.XP_009351890.1 3.09e-09 61.2 COG0330@1|root,KOG2620@2759|Eukaryota,37HFS@33090|Viridiplantae,3GF0M@35493|Streptophyta,4JIZ2@91835|fabids 35493|Streptophyta C Stomatin-like protein - GO:0006996,GO:0007005,GO:0007006,GO:0008150,GO:0009987,GO:0016043,GO:0061024,GO:0071840 - - - - - - - - - - Band_7,Band_7_C k59_251929_1 1168034.FH5T_21975 1.92e-52 175.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA k59_546826_2 749222.Nitsa_0269 1.25e-31 122.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2YMRG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H folylpolyglutamate synthase folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_741192_1 944547.ABLL_1709 3.23e-41 149.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2YNFF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P transporter - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_741192_2 598659.NAMH_1153 2.38e-12 66.2 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,42RJN@68525|delta/epsilon subdivisions,2YP6V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Divergent polysaccharide deacetylase - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_840365_1 1123020.AUIE01000008_gene3563 5.17e-46 169.0 COG0421@1|root,COG0421@2|Bacteria,1QVJA@1224|Proteobacteria,1RYYT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_709799_1 1408287.AXUR01000026_gene102 5.02e-19 90.9 COG0846@1|root,COG0846@2|Bacteria 2|Bacteria K NAD+ binding - - - - - - - - - - - - SIR2_2 k59_447339_1 1000565.METUNv1_04010 4.64e-79 248.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,2KURP@206389|Rhodocyclales 206389|Rhodocyclales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_251939_1 794903.OPIT5_03555 1.77e-94 290.0 COG0472@1|root,COG0472@2|Bacteria,46SD0@74201|Verrucomicrobia,3K7EK@414999|Opitutae 414999|Opitutae M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_155215_1 1123514.KB905899_gene1986 1.01e-93 298.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,461S8@72273|Thiotrichales 72273|Thiotrichales P Cation transporter/ATPase, N-terminus - - 3.6.3.9 ko:K01539 ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 - - - ko00000,ko00001,ko01000,ko04147 3.A.3.1 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_774955_1 1172190.M947_07405 1.72e-18 77.4 COG0255@1|root,COG0255@2|Bacteria,1Q5ZI@1224|Proteobacteria,42VCR@68525|delta/epsilon subdivisions,2YQ6C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_774955_2 563040.Saut_0222 2.23e-77 232.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2YNWG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_774955_3 326298.Suden_0292 1.19e-62 198.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2YN05@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_840964_1 1380394.JADL01000012_gene1024 9.22e-84 258.0 COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2JPCP@204441|Rhodospirillales 204441|Rhodospirillales Q homogentisate 1,2-dioxygenase - - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_188430_1 1392488.JHZY01000004_gene3198 2.04e-45 164.0 COG1874@1|root,COG1874@2|Bacteria,4NDX1@976|Bacteroidetes,1HXQ9@117743|Flavobacteriia,2XJY4@283735|Leeuwenhoekiella 976|Bacteroidetes G Glycosyl hydrolases family 35 - - - - - - - - - - - - Glyco_hydro_35,Glyco_hydro_42 k59_613213_1 555079.Toce_0243 1.72e-57 206.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.17.1.10,1.17.1.9,1.97.1.9 ko:K00123,ko:K12527,ko:K15022 ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519,R07229 RC02420,RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3 k59_516046_1 1168034.FH5T_09650 2.5e-05 45.8 COG4589@1|root,COG4589@2|Bacteria,4NIPM@976|Bacteroidetes,2FMKC@200643|Bacteroidia 976|Bacteroidetes S Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_516046_2 1168034.FH5T_09655 1.16e-24 94.0 2A7I2@1|root,30WFU@2|Bacteria,4PIFY@976|Bacteroidetes,2FW2Z@200643|Bacteroidia 976|Bacteroidetes S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_516046_3 929556.Solca_4111 4.8e-39 139.0 COG1556@1|root,COG1556@2|Bacteria,4NIGX@976|Bacteroidetes,1IRJ2@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Uncharacterised ACR, YkgG family COG1556 - - - ko:K00782 - - - - ko00000 - - - LUD_dom k59_252665_1 1127673.GLIP_2642 2.31e-14 76.3 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,46CJK@72275|Alteromonadaceae 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_383605_1 588581.Cpap_3272 2.93e-70 239.0 COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,3WSTF@541000|Ruminococcaceae 186801|Clostridia Q Beta-ketoacyl synthase - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_220824_1 1168034.FH5T_10530 8e-108 332.0 COG2335@1|root,COG2335@2|Bacteria,4NGU3@976|Bacteroidetes,2FQ02@200643|Bacteroidia 976|Bacteroidetes M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - ko:K19519 - - - - ko00000,ko04516 - - - DUF5108,Fasciclin k59_613218_1 1121926.AXWO01000026_gene2745 1.01e-42 160.0 COG2755@1|root,COG3401@1|root,COG4447@1|root,COG2755@2|Bacteria,COG3401@2|Bacteria,COG4447@2|Bacteria,2GMCU@201174|Actinobacteria 201174|Actinobacteria M cellulose binding - - - - - - - - - - - - CBM_2,fn3 k59_805011_1 76114.ebA6749 4.76e-100 303.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VRHD@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_971942_1 1278309.KB907100_gene2194 9.26e-60 206.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1XHSW@135619|Oceanospirillales 135619|Oceanospirillales P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_18885_1 580332.Slit_1609 1.09e-94 282.0 COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria,2VI6U@28216|Betaproteobacteria,44W9N@713636|Nitrosomonadales 28216|Betaproteobacteria C PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding hoxU - 1.12.1.2 ko:K18006 - - - - ko00000,ko01000 - - - Fer2_4,Fer4_15,NADH-G_4Fe-4S_3 k59_352129_1 323259.Mhun_0951 7.92e-27 115.0 COG0840@1|root,COG2770@1|root,arCOG02320@2157|Archaea,arCOG02372@2157|Archaea,2XTG0@28890|Euryarchaeota,2NA6G@224756|Methanomicrobia 224756|Methanomicrobia NT HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_18889_1 439235.Dalk_2669 8.78e-75 251.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales 28221|Deltaproteobacteria I BadF BadG BcrA BcrD - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_1036418_1 1123008.KB905715_gene3639 1.09e-75 240.0 COG0502@1|root,COG0502@2|Bacteria,4NEI7@976|Bacteroidetes,2FM8N@200643|Bacteroidia,22VVB@171551|Porphyromonadaceae 976|Bacteroidetes C In Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and IscS hydG - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM k59_613228_1 765910.MARPU_01815 2.65e-55 192.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1WX48@135613|Chromatiales 135613|Chromatiales P Ferrous iron transport protein B - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_805021_1 316067.Geob_3104 1.87e-51 177.0 COG1625@1|root,COG1625@2|Bacteria,1R76F@1224|Proteobacteria 1224|Proteobacteria C Protein of unknown function (DUF512) - - - - - - - - - - - - DUF512 k59_579789_1 1168034.FH5T_15055 1.34e-113 338.0 COG0065@1|root,COG0065@2|Bacteria,4NG7E@976|Bacteroidetes,2FMCX@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_283767_1 1278307.KB907007_gene183 1.23e-39 136.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,2QHMK@267894|Psychromonadaceae 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_283767_2 89187.ISM_16735 4.35e-13 73.9 COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,2TRZB@28211|Alphaproteobacteria,46NJW@74030|Roseovarius 28211|Alphaproteobacteria M Glycosyl transferase, group 2 family protein - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2 k59_678922_1 1487923.DP73_12425 7.96e-83 271.0 COG0427@1|root,COG0427@2|Bacteria 2|Bacteria C acetyl-CoA hydrolase activity - - - ko:K18122 ko00650,ko01100,ko01200,map00650,map01100,map01200 - R05336 RC00012,RC00014 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_252686_1 1165841.SULAR_03267 1.04e-87 264.0 COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,42NNR@68525|delta/epsilon subdivisions,2YMH0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase k59_252686_2 643867.Ftrac_1652 1.34e-39 138.0 COG0217@1|root,COG0217@2|Bacteria,4NE8Y@976|Bacteroidetes,47JWX@768503|Cytophagia 976|Bacteroidetes K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_1005095_1 1173029.JH980292_gene3313 1.14e-19 94.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7V4@1150|Oscillatoriales 1117|Cyanobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_906565_1 1049564.TevJSym_ad00500 8.72e-91 285.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP Proton-conducting membrane transporter phaD - 1.6.5.3 ko:K00342,ko:K05561,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_448261_1 1168034.FH5T_12510 2.38e-17 80.9 2E9C0@1|root,333JQ@2|Bacteria,4NVAR@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_448261_2 1168034.FH5T_20635 1.1e-55 189.0 COG1158@1|root,COG1158@2|Bacteria,4NEFP@976|Bacteroidetes,2FN7R@200643|Bacteroidia 976|Bacteroidetes K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_383651_1 1026882.MAMP_02613 0.000757 40.8 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,45ZRE@72273|Thiotrichales 72273|Thiotrichales O FeS assembly ATPase SufC sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_383651_2 768671.ThimaDRAFT_1714 2.34e-75 238.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1WWT1@135613|Chromatiales 135613|Chromatiales O TIGRFAM FeS assembly protein SufB - - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_252696_1 305900.GV64_09615 2.42e-50 173.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1XI3H@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.113 ko:K12256 ko00330,ko01100,map00330,map01100 - R08714 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_18909_1 1380380.JIAX01000001_gene2858 4.07e-17 76.3 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2963 Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_547727_1 1197906.CAJQ02000053_gene4290 1.05e-13 78.2 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JT9B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Diguanylate cyclase MA20_18100 - 3.1.4.52 ko:K13245 ko04112,map04112 - R08991 RC00296 ko00000,ko00001,ko01000 - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_3 k59_579811_1 1168034.FH5T_04110 5.82e-170 485.0 COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,2FN8N@200643|Bacteroidia 976|Bacteroidetes CO AhpC Tsa family - - - - - - - - - - - - AhpC-TSA,DUF4369,Thioredoxin_8 k59_1036453_1 1168034.FH5T_07905 8.61e-61 192.0 COG0664@1|root,COG0664@2|Bacteria,4NFB1@976|Bacteroidetes,2FSG2@200643|Bacteroidia 976|Bacteroidetes K Bacterial regulatory proteins, crp family - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1036453_2 385682.AFSL01000060_gene1757 8.93e-05 43.1 COG1765@1|root,COG1765@2|Bacteria,4NNTY@976|Bacteroidetes,2FU46@200643|Bacteroidia,3XK5V@558415|Marinilabiliaceae 976|Bacteroidetes O OsmC-like protein - - - ko:K07397 - - - - ko00000 - - - OsmC k59_971974_1 398579.Spea_0429 3.09e-83 255.0 COG0300@1|root,COG0300@2|Bacteria,1R5VP@1224|Proteobacteria,1SYZP@1236|Gammaproteobacteria,2QAYW@267890|Shewanellaceae 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_579819_1 13333.ERM97465 5.49e-23 96.7 COG0649@1|root,COG1005@1|root,KOG2870@2759|Eukaryota,KOG4770@2759|Eukaryota,37KKG@33090|Viridiplantae,3GDNP@35493|Streptophyta 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhH GO:0003674,GO:0003824,GO:0003959,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0015979,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0019866,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0032991,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0055035,GO:0055114,GO:0070469,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K05572,ko:K05579 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Complex1_49kDa,Fer4,NADHdh k59_188492_1 715451.ambt_20455 3.43e-115 334.0 COG3293@1|root,COG3293@2|Bacteria,1P5HD@1224|Proteobacteria,1RSHY@1236|Gammaproteobacteria,466JD@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3293 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DUF4096 k59_18921_1 292415.Tbd_0387 8.3e-25 100.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,1KRHN@119069|Hydrogenophilales 119069|Hydrogenophilales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_18921_2 243233.MCA1057 2.9e-44 149.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1XEUB@135618|Methylococcales 135618|Methylococcales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_481020_1 1323663.AROI01000022_gene828 8.98e-51 182.0 COG5001@1|root,COG5001@2|Bacteria,1R4H0@1224|Proteobacteria,1RS9G@1236|Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,dCache_1 k59_645793_1 1049564.TevJSym_ap00450 1.18e-82 268.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_1036475_1 595494.Tola_0537 2.73e-23 104.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1Y3G0@135624|Aeromonadales 135624|Aeromonadales NU Type 4 fimbrial assembly protein PilC - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_188497_1 357804.Ping_0808 4.03e-18 79.3 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,2QHZX@267894|Psychromonadaceae 1236|Gammaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_188497_2 95619.PM1_0203415 8.12e-60 207.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_547752_1 1408473.JHXO01000010_gene3768 3.25e-42 150.0 COG1621@1|root,COG1621@2|Bacteria,4NEYI@976|Bacteroidetes,2FM1Y@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 32 family - - 3.2.1.80 ko:K03332 ko00051,map00051 - R00879 - ko00000,ko00001,ko01000 - - - DUF4980,Glyco_hydro_32C,Glyco_hydro_32N k59_383680_1 314278.NB231_01334 2.19e-52 179.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales 135613|Chromatiales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_448299_1 472759.Nhal_3010 3.85e-60 201.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1WW8I@135613|Chromatiales 135613|Chromatiales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_252732_1 933262.AXAM01000001_gene421 1.43e-67 210.0 COG3599@1|root,COG3599@2|Bacteria,1NCAV@1224|Proteobacteria,42VH6@68525|delta/epsilon subdivisions,2WS27@28221|Deltaproteobacteria,2MJQX@213118|Desulfobacterales 28221|Deltaproteobacteria D DivIVA protein - - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA k59_939576_1 529507.PMI3589 5.28e-29 113.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,3Z1EU@583|Proteus 1236|Gammaproteobacteria J With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P epmA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576 - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_939576_2 999541.bgla_1g11160 3.69e-63 199.0 COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2VTDA@28216|Betaproteobacteria,1K450@119060|Burkholderiaceae 28216|Betaproteobacteria T GAF domain msrC - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF_2 k59_715939_1 1249627.D779_3925 1.95e-79 254.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_390514_1 765910.MARPU_15600 7.52e-40 141.0 COG0515@1|root,COG0515@2|Bacteria,1NDP8@1224|Proteobacteria 1224|Proteobacteria KLT serine threonine protein kinase - - - - - - - - - - - - - k59_485889_1 321846.PS417_25820 2.58e-70 222.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074 Metallophos k59_390526_1 666684.AfiDRAFT_0149 4.95e-77 241.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,3JQZ0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme tdcB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006520,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016854,GO:0016855,GO:0017144,GO:0018249,GO:0019538,GO:0019752,GO:0019842,GO:0030170,GO:0030378,GO:0030848,GO:0036094,GO:0036211,GO:0036361,GO:0042219,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0047661,GO:0048037,GO:0050662,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_747039_1 713586.KB900536_gene2224 1.87e-101 309.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_715951_2 1200557.JHWV01000010_gene853 2.01e-26 102.0 2DZIB@1|root,32VBF@2|Bacteria,1VBZI@1239|Firmicutes 1239|Firmicutes S Domain of unknown function DUF83 - - - - - - - - - - - - Cas_Cas4 k59_521975_1 323261.Noc_0578 1.46e-10 62.8 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1WVVR@135613|Chromatiales 135613|Chromatiales M PFAM glycosyl transferase family 9 - - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_60779_1 1168034.FH5T_08615 2.52e-106 320.0 COG2610@1|root,COG2610@2|Bacteria,4NFBD@976|Bacteroidetes 976|Bacteroidetes EG Gluconate transporter - - - ko:K03299,ko:K06156 - - - - ko00000,ko02000 2.A.8,2.A.8.1.8 - - GntP_permease k59_846245_1 1168034.FH5T_09195 6.03e-96 305.0 COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,2FM1K@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug k59_650970_1 1121405.dsmv_1235 5.99e-63 201.0 COG0412@1|root,COG0412@2|Bacteria,1NKIB@1224|Proteobacteria,43B7J@68525|delta/epsilon subdivisions,2X6KZ@28221|Deltaproteobacteria,2MMAU@213118|Desulfobacterales 28221|Deltaproteobacteria Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_321990_1 497965.Cyan7822_4213 2.08e-28 114.0 COG4409@1|root,COG4409@2|Bacteria,1GG92@1117|Cyanobacteria 1117|Cyanobacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - - k59_321990_2 395493.BegalDRAFT_0778 2.42e-256 724.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,4607X@72273|Thiotrichales 72273|Thiotrichales JKL DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_321990_4 706587.Desti_0293 1.41e-39 137.0 COG1633@1|root,COG1633@2|Bacteria,1N4PW@1224|Proteobacteria,42UZG@68525|delta/epsilon subdivisions,2WNGQ@28221|Deltaproteobacteria,2MS9U@213462|Syntrophobacterales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_321990_5 395493.BegalDRAFT_3113 2.77e-31 115.0 COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,1SAXA@1236|Gammaproteobacteria,462P4@72273|Thiotrichales 72273|Thiotrichales K Ferric uptake regulator family - - - ko:K09826 - - - - ko00000,ko03000 - - - FUR k59_321990_6 765912.Thimo_2272 2.32e-50 164.0 2ECCI@1|root,336AU@2|Bacteria,1NG5X@1224|Proteobacteria,1SUHH@1236|Gammaproteobacteria,1X1UM@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_321990_7 195250.CM001776_gene1111 4.74e-40 148.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_321990_8 1283300.ATXB01000002_gene2696 1.23e-165 506.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XFKT@135618|Methylococcales 135618|Methylococcales T PFAM Chemotaxis methyl-accepting receptor, signalling - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_8,PAS_9,TarH k59_321990_9 472759.Nhal_3529 2.39e-52 169.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1WYA2@135613|Chromatiales 135613|Chromatiales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_321990_10 95619.PM1_0204675 1.66e-38 129.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_321990_11 857087.Metme_1547 8.23e-40 148.0 2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1XER1@135618|Methylococcales 135618|Methylococcales S membrane - - - - - - - - - - - - DUF2232 k59_321990_12 519989.ECTPHS_00475 5.75e-58 184.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1WYD2@135613|Chromatiales 135613|Chromatiales J binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_321990_13 1049564.TevJSym_ac00860 1.18e-251 700.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_321990_14 472759.Nhal_3525 5.84e-138 403.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1WWIB@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_321990_15 765910.MARPU_02150 4.57e-227 637.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales 135613|Chromatiales O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_321990_16 1333856.L686_22180 7.39e-31 113.0 2E3XG@1|root,32YUI@2|Bacteria,1N8RF@1224|Proteobacteria,1SCJ3@1236|Gammaproteobacteria,1Z31R@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a - - - - - - - - - - - - PilZ k59_321990_18 765910.MARPU_12125 3.24e-185 528.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales 135613|Chromatiales P CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_321990_19 1163408.UU9_02209 9.99e-07 54.7 2EJ60@1|root,337WG@2|Bacteria,1N9QH@1224|Proteobacteria,1T8TU@1236|Gammaproteobacteria,1X80G@135614|Xanthomonadales 135614|Xanthomonadales S Atypical PilZ domain, cyclic di-GMP receptor - - - - - - - - - - - - PilZ_2 k59_321990_20 1049564.TevJSym_ac00800 1.97e-203 580.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1J5J8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleQ - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FleQ,HTH_8,Sigma54_activat k59_321990_21 1283300.ATXB01000001_gene955 1.62e-82 266.0 COG5000@1|root,COG5000@2|Bacteria,1QUG9@1224|Proteobacteria,1T1Y1@1236|Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction histidine kinase flrB - 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_8 k59_321990_22 1049564.TevJSym_ac00780 1.27e-195 556.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4Q2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleR - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_321990_23 1049564.TevJSym_ac00770 2.76e-33 117.0 COG1677@1|root,COG1677@2|Bacteria,1N6RZ@1224|Proteobacteria,1SD52@1236|Gammaproteobacteria,1J6U5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar hook-basal body fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE k59_321990_24 1049564.TevJSym_ac00760 5.84e-190 550.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,1RN6T@1236|Gammaproteobacteria,1J500@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_321990_25 1049564.TevJSym_ac00750 6.66e-163 465.0 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,1RM9B@1236|Gammaproteobacteria,1J56V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliG GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_321990_26 1049564.TevJSym_ac00740 3.35e-71 224.0 COG1317@1|root,COG1317@2|Bacteria,1NBN3@1224|Proteobacteria,1SWWK@1236|Gammaproteobacteria,1J6X3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar biosynthesis type III secretory pathway protein - - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH k59_321990_27 1049564.TevJSym_ac00730 1.41e-251 700.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,1RM9W@1236|Gammaproteobacteria,1J55H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_321990_28 1049564.TevJSym_ac00720 1.57e-42 144.0 COG2882@1|root,COG2882@2|Bacteria,1PUI7@1224|Proteobacteria,1TAJY@1236|Gammaproteobacteria,1J75K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NOU Flagellar FliJ protein - - - - - - - - - - - - FliJ k59_321990_29 1049564.TevJSym_aa02480 1.11e-93 286.0 COG0697@1|root,COG0697@2|Bacteria,1QQY8@1224|Proteobacteria,1RRQ6@1236|Gammaproteobacteria,1J7WK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_321990_33 1265313.HRUBRA_01716 8.26e-41 146.0 COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RPQR@1236|Gammaproteobacteria,1JBCV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pfam:HipA_N hipA_1 - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_226614_1 396588.Tgr7_0580 1.48e-59 204.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RQ5D@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_846249_1 1121396.KB893077_gene733 5.78e-93 280.0 COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,42MNX@68525|delta/epsilon subdivisions,2WK2W@28221|Deltaproteobacteria,2MMS8@213118|Desulfobacterales 28221|Deltaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_162316_1 610130.Closa_1121 1.45e-113 334.0 COG1073@1|root,COG1073@2|Bacteria,1TPW7@1239|Firmicutes,24A5B@186801|Clostridia,21ZQ0@1506553|Lachnoclostridium 186801|Clostridia S Dienelactone hydrolase family - - - ko:K06889 - - - - ko00000 - - - AXE1,DLH,Peptidase_S15 k59_618953_1 930169.B5T_01279 7.96e-58 199.0 COG2272@1|root,COG4222@1|root,COG2272@2|Bacteria,COG4222@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_60787_1 933262.AXAM01000041_gene1903 3.79e-41 149.0 COG1148@1|root,COG1148@2|Bacteria,1NFQN@1224|Proteobacteria,42QES@68525|delta/epsilon subdivisions,2WM5P@28221|Deltaproteobacteria,2MITE@213118|Desulfobacterales 28221|Deltaproteobacteria C Glucose inhibited division protein A - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2 k59_485916_1 593750.Metfor_2002 1.07e-12 67.8 COG2326@1|root,arCOG03575@2157|Archaea,2XV3H@28890|Euryarchaeota,2N9AK@224756|Methanomicrobia 224756|Methanomicrobia F Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_485916_2 661367.LLO_2586 8.51e-114 340.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1JCMZ@118969|Legionellales 118969|Legionellales P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 k59_289545_1 1121324.CLIT_10c01970 1.1e-19 85.5 COG3874@1|root,COG3874@2|Bacteria,1V99U@1239|Firmicutes,24K00@186801|Clostridia 186801|Clostridia S Sporulation protein YtfJ - - - - - - - - - - - - Spore_YtfJ k59_289545_2 1484460.JSWG01000007_gene3140 1.9e-31 112.0 2DZVD@1|root,32VJZ@2|Bacteria,4NUB2@976|Bacteroidetes,1I482@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - ydhR k59_258242_1 1121405.dsmv_0564 9.01e-93 304.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_618959_1 768671.ThimaDRAFT_0579 1.22e-50 168.0 COG0500@1|root,COG2226@2|Bacteria,1RKQD@1224|Proteobacteria,1RZ3N@1236|Gammaproteobacteria,1WWAS@135613|Chromatiales 135613|Chromatiales Q PFAM methyltransferase - - - - - - - - - - - - Methyltransf_25 k59_485918_1 1172190.M947_07975 6.93e-114 341.0 COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,42NVN@68525|delta/epsilon subdivisions,2YMH8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P phosphate-selective porin O and P - - - - - - - - - - - - - k59_554106_1 944546.ABED_1648 3.52e-55 181.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,42MFN@68525|delta/epsilon subdivisions,2YMGM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_554106_2 563040.Saut_0265 7.28e-75 230.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,42QY6@68525|delta/epsilon subdivisions,2YNYW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the inositol monophosphatase superfamily cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_1010385_1 1165841.SULAR_01245 1.01e-66 213.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2YMC8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1010385_2 1140001.I571_00483 8.16e-09 56.6 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,4B0G1@81852|Enterococcaceae 91061|Bacilli V ABC transporter transmembrane region yfiC - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_94862_1 1168034.FH5T_12285 8.33e-103 304.0 COG0174@1|root,COG0174@2|Bacteria,4NGG2@976|Bacteroidetes 976|Bacteroidetes E glutamine synthetase glnII - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_781627_1 428125.CLOLEP_01416 1.07e-32 118.0 2ECB3@1|root,3369E@2|Bacteria,1VEV9@1239|Firmicutes,24R69@186801|Clostridia,3WNCY@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_618963_1 572544.Ilyop_1532 1.72e-128 371.0 COG0462@1|root,COG0462@2|Bacteria,3784I@32066|Fusobacteria 32066|Fusobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_554114_1 626887.J057_14095 1.29e-62 202.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,464HA@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_554114_2 1249627.D779_3549 9.35e-42 142.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1WW34@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_94874_1 387093.SUN_1827 1.59e-94 288.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2YMUR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_390551_1 1163398.AJJP01000156_gene2823 4.46e-64 206.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_1304 GHMP_kinases_C,GHMP_kinases_N k59_715985_1 1348657.M622_04040 1.74e-52 177.0 COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2W89I@28216|Betaproteobacteria,2KY6X@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_357536_2 1122993.KB898326_gene1778 2.69e-25 108.0 COG3182@1|root,COG3182@2|Bacteria,4NJ7N@976|Bacteroidetes,2FPKX@200643|Bacteroidia 976|Bacteroidetes S PepSY domain protein - - - - - - - - - - - - PepSY_TM k59_747071_1 552811.Dehly_1698 1.25e-129 374.0 28J6X@1|root,2Z92E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_127942_1 1168034.FH5T_08535 5.18e-124 375.0 COG1554@1|root,COG1554@2|Bacteria,4NFG1@976|Bacteroidetes,2FME6@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolase family 65 central catalytic domain - - 2.4.1.8 ko:K00691 ko00500,ko01100,map00500,map01100 - R01555 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m k59_195140_2 572544.Ilyop_1479 9.07e-29 111.0 COG0061@1|root,COG0061@2|Bacteria,37A1D@32066|Fusobacteria 32066|Fusobacteria H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_456032_1 1131814.JAFO01000001_gene447 1.34e-13 77.8 COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,2TQTY@28211|Alphaproteobacteria,3F07I@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - - - - - - - - - - DUF2235 k59_685384_1 1049564.TevJSym_ac01740 1.69e-53 191.0 28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phosphoenolpyruvate carboxykinase (diphosphate) activity - - 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 - R00346 RC02741 ko00000,ko00001,ko01000 - - - - k59_782283_1 1121396.KB893125_gene4531 4.46e-67 212.0 COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MIPS@213118|Desulfobacterales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_782283_2 1121396.KB893125_gene4532 2.2e-20 85.1 COG3090@1|root,COG3090@2|Bacteria,1N9EF@1224|Proteobacteria,42WJB@68525|delta/epsilon subdivisions,2WRDN@28221|Deltaproteobacteria,2MK1K@213118|Desulfobacterales 28221|Deltaproteobacteria G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_486748_1 572544.Ilyop_1734 1.93e-101 309.0 COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,378DH@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 k59_522710_1 1121904.ARBP01000005_gene4880 6.31e-78 243.0 COG1748@1|root,COG1748@2|Bacteria,4NFM8@976|Bacteroidetes 976|Bacteroidetes E Saccharopine dehydrogenase - - - - - - - - - - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_879445_1 1121921.KB898708_gene1533 2.16e-39 152.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,2PN2Z@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L SMC proteins Flexible Hinge Domain smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_846946_1 1463900.JOIX01000022_gene7202 1.02e-12 68.6 COG1136@1|root,COG1136@2|Bacteria,2GNB3@201174|Actinobacteria 201174|Actinobacteria V ABC transporter hrtA - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_846946_2 243233.MCA0133 1.71e-22 97.1 COG0552@1|root,COG1612@1|root,COG0552@2|Bacteria,COG1612@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XE6A@135618|Methylococcales 135618|Methylococcales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - COX15-CtaA,SRP54,SRP54_N k59_391196_1 1168034.FH5T_01535 6.53e-114 342.0 COG0493@1|root,COG0493@2|Bacteria,4P2CU@976|Bacteroidetes,2FXPN@200643|Bacteroidia 976|Bacteroidetes E 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2_4,Fer4_20 k59_391196_2 1168034.FH5T_01530 3.59e-40 147.0 COG1520@1|root,COG1520@2|Bacteria,4P310@976|Bacteroidetes 976|Bacteroidetes S PQQ-like domain - - - - - - - - - - - - PQQ_3 k59_394602_2 426117.M446_0082 1.94e-13 72.0 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,2TW9Z@28211|Alphaproteobacteria,1JTWQ@119045|Methylobacteriaceae 28211|Alphaproteobacteria V secretion protein HlyD family yhiI - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_231259_2 1232683.ADIMK_4184 1.03e-54 190.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVK@1236|Gammaproteobacteria,466PE@72275|Alteromonadaceae 1236|Gammaproteobacteria KLT Sulfatase-modifying factor enzyme 1 - - - ko:K20333 ko02024,map02024 - - - ko00000,ko00001 - - - FGE-sulfatase,Pkinase k59_982867_1 634499.EpC_21560 9.33e-79 261.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,3X65U@551|Erwinia 1236|Gammaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne GO:0000287,GO:0000966,GO:0000967,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008312,GO:0008995,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0017151,GO:0019222,GO:0019439,GO:0019899,GO:0022607,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034655,GO:0034660,GO:0042254,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043462,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0046872,GO:0048519,GO:0050789,GO:0050790,GO:0051095,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051336,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902280 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - PNPase_C,RNase_E_G,S1 k59_394610_1 1255043.TVNIR_0484 7.97e-76 243.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales 135613|Chromatiales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_329418_2 697281.Mahau_1312 4.51e-40 141.0 COG0637@1|root,COG0637@2|Bacteria,1V1NW@1239|Firmicutes,24G37@186801|Clostridia,42G6E@68295|Thermoanaerobacterales 186801|Clostridia S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - - - - - - - - - - Acetyltransf_3,HAD_2 k59_296469_1 1565314.OA34_02480 8.16e-51 170.0 COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,42QZE@68525|delta/epsilon subdivisions,2YSAJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TPM domain - - - ko:K08988 - - - - ko00000 - - - TPM_phosphatase k59_623441_1 572544.Ilyop_0012 5.56e-120 367.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,378F8@32066|Fusobacteria 32066|Fusobacteria J Phenylalanyl-tRNA synthetase beta pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_623441_2 572544.Ilyop_0015 2.43e-89 265.0 COG0193@1|root,COG0193@2|Bacteria,379XT@32066|Fusobacteria 32066|Fusobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_362134_1 323261.Noc_0233 5.2e-79 243.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales 135613|Chromatiales M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_852434_1 879212.DespoDRAFT_02234 8.54e-101 300.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RJT0@1224|Proteobacteria,43CRQ@68525|delta/epsilon subdivisions,2X7ZB@28221|Deltaproteobacteria,2MPB2@213118|Desulfobacterales 28221|Deltaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_525452_1 96561.Dole_2101 5.71e-97 300.0 COG2414@1|root,COG2414@2|Bacteria,1R8M4@1224|Proteobacteria,42PRY@68525|delta/epsilon subdivisions,2WIS4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.6 ko:K11389 ko00010,ko01100,ko01120,ko01200,ko01230,map00010,map01100,map01120,map01200,map01230 M00001,M00002 R07159 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_950417_1 1537917.JU82_07175 1.12e-77 258.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2YMA1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_67555_1 1307759.JOMJ01000003_gene965 3.65e-81 240.0 28PKN@1|root,2ZCA1@2|Bacteria,1RARD@1224|Proteobacteria,42QYT@68525|delta/epsilon subdivisions,2WMUD@28221|Deltaproteobacteria,2MBDB@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_394619_1 387093.SUN_0007 3.06e-114 337.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2YM81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Cysteine desulfurase iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_786824_1 556261.HMPREF0240_01867 1.09e-64 212.0 COG3039@1|root,COG3039@2|Bacteria,1TPFS@1239|Firmicutes,249JM@186801|Clostridia,36E38@31979|Clostridiaceae 186801|Clostridia L This gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_133239_1 2340.JV46_25920 4.21e-18 83.2 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1J7PM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_133239_2 1249627.D779_0321 1.85e-55 183.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1WW9Z@135613|Chromatiales 135613|Chromatiales S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_362140_1 626887.J057_22535 3.7e-36 132.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,464FS@72275|Alteromonadaceae 1236|Gammaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_362140_2 765912.Thimo_2648 1.4e-87 265.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales 135613|Chromatiales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_786827_1 439235.Dalk_1460 1.79e-65 222.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MJ5T@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_884663_2 1150621.SMUL_2492 8.64e-54 181.0 COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,42M2P@68525|delta/epsilon subdivisions,2YNS6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Glycosyltransferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1015589_1 1216007.AOPM01000040_gene2733 1.87e-49 169.0 COG4667@1|root,COG4667@2|Bacteria,1PV7M@1224|Proteobacteria,1RRPR@1236|Gammaproteobacteria,2Q1FA@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_558223_1 1410628.JNKS01000005_gene1208 1.66e-68 213.0 COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,247WC@186801|Clostridia,27JWB@186928|unclassified Lachnospiraceae 186801|Clostridia E Imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_558223_2 1121324.CLIT_11c01300 5.5e-106 319.0 COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia 186801|Clostridia E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_884667_1 1121935.AQXX01000065_gene1675 1.02e-48 164.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1XJ8Z@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_34671_1 517417.Cpar_0875 5.55e-220 617.0 COG1252@1|root,COG1252@2|Bacteria 2|Bacteria C NADH dehydrogenase - - 1.6.99.3,1.8.5.4 ko:K03885,ko:K17218 ko00190,ko00920,map00190,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_34671_2 1537917.JU82_11575 2.98e-25 99.8 COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,42PJH@68525|delta/epsilon subdivisions,2YP5Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P uptake protein ktrA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_492714_1 1229205.BUPH_02615 5.83e-239 671.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria,1K5SV@119060|Burkholderiaceae 28216|Betaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_23,HTH_24,rve k59_492714_2 1121923.GPUN_1204 4.6e-131 377.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,1RPJM@1236|Gammaproteobacteria,4686R@72275|Alteromonadaceae 1236|Gammaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_492714_3 316067.Geob_3252 8.06e-96 284.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,42PP3@68525|delta/epsilon subdivisions,2WK0G@28221|Deltaproteobacteria,43SJH@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_590727_2 59196.RICGR_0633 0.000177 49.3 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1JCQ5@118969|Legionellales 118969|Legionellales I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD_1 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_982902_1 1297865.APJD01000020_gene155 1.36e-53 170.0 COG4319@1|root,COG4319@2|Bacteria,1PIQU@1224|Proteobacteria,2UXCH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ketosteroid isomerase - - - - - - - - - - - - - k59_917895_2 998088.B565_0695 5.48e-08 53.9 COG3895@1|root,COG4461@1|root,COG3895@2|Bacteria,COG4461@2|Bacteria,1R6Q3@1224|Proteobacteria,1S2QD@1236|Gammaproteobacteria,1Y4Y7@135624|Aeromonadales 135624|Aeromonadales S protein conserved in bacteria - - - - - - - - - - - - LprI,MliC k59_1739_1 572480.Arnit_0031 1.35e-46 165.0 COG1956@1|root,COG3604@1|root,COG1956@2|Bacteria,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2YNEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF_2,HTH_8,Sigma54_activat k59_134170_1 908338.HMPREF9286_1621 8.88e-05 50.4 COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,249U2@186801|Clostridia,22G0J@1570339|Peptoniphilaceae 186801|Clostridia S Metallo-beta-lactamase domain protein yycJ - - - - - - - - - - - Lactamase_B,Lactamase_B_2 k59_134170_2 391612.CY0110_24076 1.84e-155 447.0 COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria,3KK9I@43988|Cyanothece 1117|Cyanobacteria H Belongs to the deoxyhypusine synthase family - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_134170_3 323259.Mhun_0113 1.06e-81 246.0 COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia 224756|Methanomicrobia E Belongs to the PdaD family pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC k59_134170_5 1499967.BAYZ01000028_gene1340 3.77e-46 152.0 COG3339@1|root,COG3339@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_134170_6 526218.Sterm_3811 3.31e-68 216.0 COG4420@1|root,COG4420@2|Bacteria,37CEF@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF1003 k59_134170_7 1279017.AQYJ01000028_gene2401 5.41e-37 152.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,465SK@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 13 family pulA - 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 - R02111 - ko00000,ko00001,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3372,PUD k59_624208_2 765911.Thivi_0952 3.5e-28 112.0 COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,1T4ST@1236|Gammaproteobacteria,1WW05@135613|Chromatiales 135613|Chromatiales O Belongs to the heme-copper respiratory oxidase family - - - - - - - - - - - - - k59_134175_1 1265505.ATUG01000001_gene4529 1.04e-35 125.0 COG4683@1|root,COG4683@2|Bacteria 2|Bacteria K PFAM Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 k59_918823_1 1168034.FH5T_08545 9.04e-123 367.0 COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,2FNVI@200643|Bacteroidia 976|Bacteroidetes G Alpha amylase, catalytic domain protein amyA - - - - - - - - - - - Alpha-amylase,Alpha-amylase_C,tRNA_SAD k59_722321_1 709032.Sulku_0460 9.89e-21 95.9 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2YM9V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_657365_1 1168034.FH5T_08720 6.05e-105 330.0 COG3947@1|root,COG3947@2|Bacteria,4NFJU@976|Bacteroidetes,2FN4F@200643|Bacteroidia 976|Bacteroidetes T COG NOG26059 non supervised orthologous group - - - - - - - - - - - - Laminin_G_3 k59_657365_2 1168034.FH5T_08710 1.29e-31 117.0 COG0637@1|root,COG0637@2|Bacteria 2|Bacteria S phosphonoacetaldehyde hydrolase activity pgmB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576 2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6 ko:K01087,ko:K01194,ko:K01838,ko:K05342 ko00500,ko01100,map00500,map01100 - R00010,R02727,R02728,R02778,R11310 RC00017,RC00049,RC00408 ko00000,ko00001,ko00537,ko01000 - GH37,GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase,Trehalose_PPase k59_330292_1 1168034.FH5T_19665 1.95e-99 313.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,2FS4M@200643|Bacteroidia 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 k59_689705_1 1195246.AGRI_08715 8.03e-07 50.1 COG1051@1|root,COG1051@2|Bacteria,1RB8R@1224|Proteobacteria,1S1A6@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_689705_2 642492.Clole_4183 2.32e-160 464.0 COG1690@1|root,COG1690@2|Bacteria,1TPJ2@1239|Firmicutes,2481V@186801|Clostridia 186801|Clostridia S Belongs to the RtcB family - - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_232054_1 1165841.SULAR_07735 6.52e-85 268.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2YNP4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_232054_2 596319.STAWA0001_0736 1.15e-05 46.2 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,4GYXG@90964|Staphylococcaceae 91061|Bacilli J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_68375_1 572544.Ilyop_1716 1.1e-274 768.0 COG1154@1|root,COG1154@2|Bacteria,378P4@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_754703_1 1163617.SCD_n02712 5.08e-55 179.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,2VPFB@28216|Betaproteobacteria 28216|Betaproteobacteria C Nitrate reductase gamma subunit - - - - - - - - - - - - Nitrate_red_gam k59_754703_2 864051.BurJ1DRAFT_3331 4.35e-54 171.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,2VSFJ@28216|Betaproteobacteria 28216|Betaproteobacteria P DsrC like protein - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_885378_1 1122604.JONR01000002_gene1622 3.94e-89 287.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1X4NM@135614|Xanthomonadales 135614|Xanthomonadales C E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_493617_1 1165841.SULAR_07053 1.69e-71 220.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,42SB8@68525|delta/epsilon subdivisions,2YPI9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA gidB - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_493617_2 387093.SUN_2076 3.17e-19 80.9 2DRDY@1|root,33BC0@2|Bacteria,1NHDE@1224|Proteobacteria,42WZU@68525|delta/epsilon subdivisions,2YS89@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Coenzyme PQQ synthesis protein D (PqqD) - - - - - - - - - - - - PqqD k59_853258_1 338969.Rfer_0806 1.57e-106 316.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VICP@28216|Betaproteobacteria,4AEPS@80864|Comamonadaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_918841_1 709032.Sulku_1233 9.87e-140 412.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2YMP0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H arginine decarboxylase speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0422 Orn_Arg_deC_N k59_820362_4 1123392.AQWL01000003_gene291 1.49e-22 88.6 2ESIQ@1|root,33K3E@2|Bacteria,1NJ20@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_820362_5 870187.Thini_2823 2.57e-104 313.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,4609F@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_199201_1 1004785.AMBLS11_04085 5.21e-211 617.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,46ABP@72275|Alteromonadaceae 1236|Gammaproteobacteria P receptor - - - - - - - - - - - - Plug,STN,TonB_dep_Rec k59_983674_1 760192.Halhy_0886 2.95e-42 159.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IWHI@117747|Sphingobacteriia 976|Bacteroidetes M Tricorn protease PDZ domain - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_951339_1 645991.Sgly_0639 6.47e-10 58.5 COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,261XI@186807|Peptococcaceae 186801|Clostridia K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_951339_2 339671.Asuc_1940 7.82e-26 105.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1Y71P@135625|Pasteurellales 135625|Pasteurellales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_657393_1 269799.Gmet_2565 2.49e-41 146.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria 28221|Deltaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_885392_1 1229487.AMYW01000014_gene2948 6.99e-113 329.0 COG1262@1|root,COG1262@2|Bacteria,4NEUZ@976|Bacteroidetes,1HYG0@117743|Flavobacteriia,2NV11@237|Flavobacterium 976|Bacteroidetes S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase k59_526424_1 933262.AXAM01000002_gene525 4.56e-67 230.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,2MIWZ@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iAF987.Gmet_1487 GATase_6,SIS k59_264385_1 439235.Dalk_5028 1.32e-49 179.0 COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2MIMK@213118|Desulfobacterales 28221|Deltaproteobacteria T Stage II sporulation protein E (SpoIIE) - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,SpoIIE,dCache_1,dCache_2 k59_493634_1 314345.SPV1_00857 7.84e-51 175.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria 1224|Proteobacteria S Major facilitator Superfamily MA20_25070 - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_493634_2 1278309.KB907100_gene1833 4.23e-24 100.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1XHRK@135619|Oceanospirillales 135619|Oceanospirillales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_199212_1 289376.THEYE_A0923 1.43e-75 251.0 COG0841@1|root,COG0841@2|Bacteria,3J0XV@40117|Nitrospirae 40117|Nitrospirae V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K07788,ko:K07789 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_1016453_1 1319815.HMPREF0202_01142 1.52e-56 180.0 COG1396@1|root,COG1396@2|Bacteria,37A1B@32066|Fusobacteria 32066|Fusobacteria K PFAM Cupin 2 conserved barrel domain protein - - - - - - - - - - - - Cupin_2,HTH_19 k59_1016453_2 999411.HMPREF1092_02164 4.74e-205 576.0 COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,36DDF@31979|Clostridiaceae 186801|Clostridia H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1016453_3 1304284.L21TH_0234 9.32e-145 414.0 COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,36U5Z@31979|Clostridiaceae 186801|Clostridia E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_1016453_4 1033810.HLPCO_001320 3.97e-163 461.0 COG0421@1|root,COG0421@2|Bacteria,2NPMY@2323|unclassified Bacteria 2|Bacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_1016453_5 572544.Ilyop_1205 6.64e-93 271.0 COG1586@1|root,COG1586@2|Bacteria,37ARN@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_657402_1 1168034.FH5T_18950 1.66e-123 372.0 COG0706@1|root,COG0706@2|Bacteria,4NESJ@976|Bacteroidetes,2FN3A@200643|Bacteroidia 976|Bacteroidetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_140305_1 4155.Migut.D01328.1.p 7.44e-69 210.0 COG0096@1|root,KOG1754@2759|Eukaryota,37UMN@33090|Viridiplantae,3GIWP@35493|Streptophyta,44TEK@71274|asterids 35493|Streptophyta J Ribosomal protein S8 rps8 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0031967,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14,Ribosomal_L16,Ribosomal_S8 k59_858696_1 1306406.ASHX01000001_gene2726 1.11e-45 166.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_32 k59_108000_1 1168034.FH5T_05050 2.94e-56 187.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,4NEJ3@976|Bacteroidetes,2FM6X@200643|Bacteroidia 976|Bacteroidetes IM Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ - 3.5.1.108,4.2.1.59 ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 - - - FabA,LpxC k59_597857_1 926560.KE387027_gene261 2.92e-61 213.0 COG2202@1|root,COG2203@1|root,COG4191@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,1WMF2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9 k59_401216_1 631362.Thi970DRAFT_01214 2.05e-97 293.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1WW13@135613|Chromatiales 135613|Chromatiales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_467310_1 1205753.A989_15232 1.58e-39 147.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1X3CQ@135614|Xanthomonadales 135614|Xanthomonadales E Transporter yhiP - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_269919_1 1121434.AULY01000006_gene272 1.7e-23 105.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - DUF3365,GAF,GAF_2,HAMP,HATPase_c,HTH_31,HisKA,Hpt,PAS,PAS_4,PAS_8,Response_reg,SBP_bac_3 k59_205688_1 765912.Thimo_2012 6.96e-50 172.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1WXPP@135613|Chromatiales 135613|Chromatiales G pfam mofrl - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_75129_2 1207076.ALAT01000036_gene4152 1.11e-79 245.0 COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,1S9I3@1236|Gammaproteobacteria,1Z2RY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L COG1525 Micrococcal nuclease (thermonuclease) homologs Z012_04225 GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - Excalibur,SNase k59_369282_1 1168034.FH5T_20565 4.14e-77 257.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_597869_1 38654.XP_006033617.1 3.07e-05 51.6 28KV9@1|root,2QTBN@2759|Eukaryota,38DU3@33154|Opisthokonta,3BBCZ@33208|Metazoa,3CTUR@33213|Bilateria,485U4@7711|Chordata,49320@7742|Vertebrata 33208|Metazoa S hydrolase activity TMEM62 - - - - - - - - - - - Metallophos k59_891501_2 1094980.Mpsy_0797 1.17e-41 144.0 COG0221@1|root,arCOG01711@2157|Archaea,2XTSU@28890|Euryarchaeota,2NAH8@224756|Methanomicrobia 224756|Methanomicrobia C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - iAF692.Mbar_A1481 Pyrophosphatase k59_891501_5 35841.BT1A1_3509 8.83e-09 64.7 COG0739@1|root,COG0739@2|Bacteria,1TRWJ@1239|Firmicutes,4HB43@91061|Bacilli,1ZBXH@1386|Bacillus 91061|Bacilli M G5 nlpD - - - - - - - - - - - G5,LysM,Peptidase_M23 k59_760374_1 1049564.TevJSym_ac00330 1.89e-64 206.0 2CGG3@1|root,33XQ6@2|Bacteria,1NWYE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_205699_2 1117647.M5M_09505 8.44e-50 168.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,1J4BZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2333 k59_792054_1 435908.IDSA_08580 7.23e-05 43.9 2EFT3@1|root,339J3@2|Bacteria,1NH28@1224|Proteobacteria,1SI3W@1236|Gammaproteobacteria,2QGC8@267893|Idiomarinaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_792054_2 228405.HNE_2398 3.15e-82 259.0 COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,43WHM@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_891504_1 1121011.AUCB01000034_gene893 3.42e-67 218.0 COG2133@1|root,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - - k59_695570_1 765910.MARPU_07805 4.86e-140 422.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WXMA@135613|Chromatiales 135613|Chromatiales T Chemotaxis sensory transducer - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_695570_2 1122201.AUAZ01000001_gene2224 1.77e-104 326.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,465ZX@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_695570_3 488538.SAR116_1166 1.33e-105 324.0 COG2248@1|root,COG2248@2|Bacteria,1MVZY@1224|Proteobacteria,2TTII@28211|Alphaproteobacteria,4BRVU@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Putative, 10TM heavy-metal exporter - - - - - - - - - - - - ArsP_2 k59_695570_4 765913.ThidrDRAFT_1422 2.62e-154 441.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_695570_5 768671.ThimaDRAFT_3925 8.05e-41 140.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,1RPQV@1236|Gammaproteobacteria,1WVZT@135613|Chromatiales 135613|Chromatiales O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_990207_1 1165841.SULAR_02473 3.94e-136 392.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,42MVI@68525|delta/epsilon subdivisions,2YMGY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C aldo keto reductase tas - - - - - - - - - - - Aldo_ket_red k59_925222_1 1121396.KB893061_gene2710 3.5e-61 199.0 COG0042@1|root,COG0042@2|Bacteria,1QDJE@1224|Proteobacteria,42PCR@68525|delta/epsilon subdivisions,2WKBH@28221|Deltaproteobacteria,2MJ5C@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - - - - - - - - - - Dus k59_858726_2 9823.ENSSSCP00000011334 6.02e-13 72.4 COG5640@1|root,KOG1217@1|root,KOG1217@2759|Eukaryota,KOG3627@2759|Eukaryota,38EF1@33154|Opisthokonta,3BJ95@33208|Metazoa,3CRAT@33213|Bilateria,488EG@7711|Chordata,496RB@7742|Vertebrata,3JAFN@40674|Mammalia,4IZTP@91561|Cetartiodactyla 33208|Metazoa T hyaluronan binding protein 2 HABP2 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005539,GO:0005575,GO:0005576,GO:0005615,GO:0006508,GO:0006807,GO:0007155,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009605,GO:0009607,GO:0009620,GO:0010033,GO:0010243,GO:0016787,GO:0017171,GO:0019538,GO:0022610,GO:0042221,GO:0043170,GO:0043207,GO:0044238,GO:0044421,GO:0046677,GO:0050896,GO:0051704,GO:0051707,GO:0070011,GO:0071704,GO:0097367,GO:0140096,GO:1901564,GO:1901652,GO:1901698,GO:1901700,GO:1904975 - ko:K08648,ko:K09640 - - - - ko00000,ko00536,ko01000,ko01002 - - - EGF,Kringle,Trypsin k59_500362_1 929558.SMGD1_0895 2.02e-54 173.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,42SHZ@68525|delta/epsilon subdivisions,2YPDZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_500362_2 563040.Saut_0316 2.59e-21 87.4 COG0244@1|root,COG0244@2|Bacteria,1RB0Y@1224|Proteobacteria,43B5K@68525|delta/epsilon subdivisions,2YPHB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_401243_1 1254432.SCE1572_17685 3.02e-66 228.0 COG0515@1|root,COG2203@1|root,COG3829@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YTVN@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory protein, Fis family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Pkinase,PocR,Sigma54_activat k59_695579_1 1168034.FH5T_10715 2.21e-95 298.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,2FS4M@200643|Bacteroidia 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 k59_565466_1 1123326.JFBL01000001_gene1334 6.82e-112 332.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,42P89@68525|delta/epsilon subdivisions,2YN9D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NifD NifK NifE NifN family - - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_858727_1 1168034.FH5T_00165 8.46e-16 77.0 COG1572@1|root,COG1572@2|Bacteria,4PM6M@976|Bacteroidetes,2FXM1@200643|Bacteroidia 976|Bacteroidetes S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA,CARDB k59_858727_2 1168034.FH5T_00170 1.17e-162 462.0 COG4992@1|root,COG4992@2|Bacteria,4NE93@976|Bacteroidetes,2FMPQ@200643|Bacteroidia 976|Bacteroidetes E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family rocD - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_760401_1 367737.Abu_1735 4.19e-92 283.0 COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1RE9S@1224|Proteobacteria,43ANP@68525|delta/epsilon subdivisions,2YT2J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_891525_1 1242969.ATCC51562_1831 1.12e-41 145.0 COG1040@1|root,COG1040@2|Bacteria,1Q1C2@1224|Proteobacteria,42T93@68525|delta/epsilon subdivisions,2YPEB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S transformation system protein ctsW - - ko:K02242 - M00429 - - ko00000,ko00002,ko02044 - - - Pribosyltran k59_6041_1 1441629.PCH70_26440 2e-53 190.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_663751_2 935848.JAEN01000006_gene3154 1.01e-21 102.0 COG3188@1|root,COG3188@2|Bacteria,1MWV6@1224|Proteobacteria,2TU95@28211|Alphaproteobacteria,2PYIZ@265|Paracoccus 28211|Alphaproteobacteria NU Outer membrane usher protein - - - ko:K07347 ko05133,map05133 - - - ko00000,ko00001,ko02000,ko02035,ko02044 1.B.11.3 - - PapC_C,Usher k59_337190_1 697282.Mettu_2697 7.51e-32 121.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1XE4Q@135618|Methylococcales 135618|Methylococcales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_401245_1 1268072.PSAB_02230 8.76e-165 468.0 COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,4HBX5@91061|Bacilli,26STF@186822|Paenibacillaceae 91061|Bacilli C Voltage-gated potassium channel - - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red k59_401245_2 666686.B1NLA3E_13925 4.84e-73 228.0 COG0599@1|root,COG0599@2|Bacteria,1TQGP@1239|Firmicutes,4IQRK@91061|Bacilli,1ZRN0@1386|Bacillus 91061|Bacilli S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_956777_1 1168034.FH5T_02775 1.97e-109 328.0 COG3172@1|root,COG3172@2|Bacteria,4NEQF@976|Bacteroidetes,2FN8P@200643|Bacteroidia 976|Bacteroidetes H Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF4301 k59_533097_1 1089551.KE386572_gene2379 1.42e-33 132.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria,4BP6F@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T CheY-like receiver, AAA-type ATPase, and DNA-binding domains ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_533097_2 1500894.JQNN01000001_gene3707 6.61e-29 115.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,476ER@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_533104_1 290398.Csal_1227 2.74e-16 78.6 2E3D3@1|root,32YCC@2|Bacteria,1NAK2@1224|Proteobacteria,1SED0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_533104_2 631362.Thi970DRAFT_00034 1.02e-13 67.8 COG3011@1|root,COG3011@2|Bacteria,1PV30@1224|Proteobacteria,1SCCX@1236|Gammaproteobacteria,1WZJ7@135613|Chromatiales 135613|Chromatiales S Protein of unknown function, DUF393 - - - - - - - - - - - - DUF393 k59_695605_1 1461693.ATO10_05467 1.33e-14 79.3 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TVI7@28211|Alphaproteobacteria 28211|Alphaproteobacteria M protein involved in outer membrane biogenesis - - - ko:K07289 - - - - ko00000 - - - AsmA,AsmA_2 k59_990242_1 314278.NB231_07942 1.7e-104 318.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family cysC - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_269959_1 591157.SSLG_03493 5.04e-92 276.0 28M46@1|root,2ZAI5@2|Bacteria,2H1QG@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_269959_2 323261.Noc_1367 1.45e-54 189.0 COG1743@1|root,COG1743@2|Bacteria,1P7I6@1224|Proteobacteria,1RY2K@1236|Gammaproteobacteria,1WXME@135613|Chromatiales 135613|Chromatiales L DNA methylase - - - - - - - - - - - - HTH_31,N6_N4_Mtase k59_792087_1 1041147.AUFB01000032_gene5858 3.29e-24 103.0 COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2U0B6@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_205749_1 857087.Metme_0281 2.25e-70 239.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1XE8U@135618|Methylococcales 135618|Methylococcales M Penicillin-binding protein 1A mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_75189_1 563040.Saut_1283 5.1e-17 79.0 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,42T86@68525|delta/epsilon subdivisions 1224|Proteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_75189_2 929558.SMGD1_0740 0.000504 42.0 COG1262@1|root,COG1352@1|root,COG1262@2|Bacteria,COG1352@2|Bacteria,1MUNC@1224|Proteobacteria,42N4Y@68525|delta/epsilon subdivisions,2YNCE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - DinB_2,FGE-sulfatase,Methyltransf_11,Methyltransf_31 k59_369342_1 1172190.M947_02030 2.57e-133 394.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2YMSG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the 5'-nucleotidase family soxB - 3.1.3.6,3.1.4.16 ko:K01119,ko:K17224 ko00230,ko00240,ko00920,ko01100,ko01120,map00230,map00240,map00920,map01100,map01120 M00595 R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135,R10151 RC00078,RC00296,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C,Metallophos k59_695612_1 933262.AXAM01000072_gene2243 4.66e-34 131.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQ2S@213118|Desulfobacterales 28221|Deltaproteobacteria C FAD binding domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,FlpD,Pyr_redox_2 k59_695612_2 1121403.AUCV01000001_gene778 1.25e-26 108.0 COG0247@1|root,COG1908@1|root,COG0247@2|Bacteria,COG1908@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MIBB@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8,Fer4_9,FlpD k59_533118_1 1173024.KI912151_gene1870 1.5e-32 127.0 COG1653@1|root,COG1653@2|Bacteria,1G0AA@1117|Cyanobacteria,1JJ8D@1189|Stigonemataceae 1117|Cyanobacteria G Bacterial extracellular solute-binding protein ugpB - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 k59_108069_1 765914.ThisiDRAFT_1694 2.14e-38 131.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1WYQC@135613|Chromatiales 135613|Chromatiales J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_108069_2 1380387.JADM01000019_gene3263 5.34e-26 107.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1XHW3@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_269968_1 1172190.M947_04425 2.18e-81 270.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2YNJ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cznA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_990259_2 945713.IALB_2341 2.19e-47 165.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_826529_1 765869.BDW_07220 3.62e-25 105.0 COG1073@1|root,COG1073@2|Bacteria,1MZUA@1224|Proteobacteria,431FI@68525|delta/epsilon subdivisions,2WX1E@28221|Deltaproteobacteria 28221|Deltaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_6 k59_630608_1 177437.HRM2_43490 1.15e-77 236.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42QN7@68525|delta/epsilon subdivisions,2WP27@28221|Deltaproteobacteria,2MNGB@213118|Desulfobacterales 28221|Deltaproteobacteria E Aconitase C-terminal domain leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_40787_1 439235.Dalk_3391 5.87e-47 167.0 COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,42NUH@68525|delta/epsilon subdivisions,2WISE@28221|Deltaproteobacteria,2MI4T@213118|Desulfobacterales 28221|Deltaproteobacteria Q PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_533138_1 1537917.JU82_01710 1.5e-61 199.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2YMZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_75214_1 1123008.KB905711_gene782 1.13e-56 190.0 COG1082@1|root,COG2133@1|root,COG1082@2|Bacteria,COG2133@2|Bacteria,4NFKF@976|Bacteroidetes,2FRR2@200643|Bacteroidia,22XIX@171551|Porphyromonadaceae 976|Bacteroidetes G Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 k59_565523_2 2340.JV46_24530 2.3e-60 191.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1J68X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 - ko:K03664 - - - - ko00000 - - - SmpB k59_205771_1 390235.PputW619_3124 1.12e-12 78.2 2EI2Z@1|root,33BUF@2|Bacteria,1NND7@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_173408_1 1120705.FG95_01036 8.8e-71 228.0 COG1073@1|root,COG1073@2|Bacteria,1R2CS@1224|Proteobacteria,2TZHJ@28211|Alphaproteobacteria,2KBAC@204457|Sphingomonadales 204457|Sphingomonadales S BAAT / Acyl-CoA thioester hydrolase C terminal - - - - - - - - - - - - - k59_40789_1 1453505.JASY01000001_gene3245 3.12e-33 136.0 COG2755@1|root,COG3866@1|root,COG4677@1|root,COG2755@2|Bacteria,COG3866@2|Bacteria,COG4677@2|Bacteria,4NEEI@976|Bacteroidetes,1IK65@117743|Flavobacteriia 2|Bacteria G PFAM Pectinesterase pemA GO:0005575,GO:0005576 3.1.1.11 ko:K01051,ko:K10297 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000,ko04121 - - - Beta_helix,Pectinesterase k59_500382_1 588581.Cpap_2791 1.93e-99 307.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,249X1@186801|Clostridia,3WJCU@541000|Ruminococcaceae 186801|Clostridia C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_500382_2 572544.Ilyop_0470 5.39e-76 228.0 COG0251@1|root,COG0251@2|Bacteria,37CQN@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score 9.97 - - - - - - - - - - - - Ribonuc_L-PSP k59_500382_3 572544.Ilyop_0469 5.75e-222 617.0 COG0665@1|root,COG0665@2|Bacteria 2|Bacteria E tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity agaE - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_500382_4 931276.Cspa_c49090 1.05e-56 177.0 COG1251@1|root,COG1251@2|Bacteria,1V9BG@1239|Firmicutes,24M0B@186801|Clostridia,36J5X@31979|Clostridiaceae 186801|Clostridia C BFD-like [2Fe-2S] binding domain - - - - - - - - - - - - Fer2_BFD k59_238670_1 387093.SUN_0854 1.11e-49 172.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions 1224|Proteobacteria P Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_275612_1 1168034.FH5T_13795 5.25e-124 360.0 COG0468@1|root,COG0468@2|Bacteria,4NEXT@976|Bacteroidetes,2FN5D@200643|Bacteroidia 976|Bacteroidetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_309150_1 414684.RC1_3723 6.55e-27 110.0 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_80965_1 1265505.ATUG01000003_gene718 5.15e-50 174.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PGC@68525|delta/epsilon subdivisions,2WKHK@28221|Deltaproteobacteria,2MJ4J@213118|Desulfobacterales 28221|Deltaproteobacteria T ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,dCache_3 k59_1028469_1 1168034.FH5T_08765 1.33e-197 573.0 COG3250@1|root,COG3250@2|Bacteria,4NE7H@976|Bacteroidetes,2FN2H@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolase family 2, sugar binding domain protein csxA_2 - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_N k59_898303_1 1274.HX89_11720 8.55e-07 57.8 COG2182@1|root,COG2182@2|Bacteria,2I0UI@201174|Actinobacteria,1ZWKX@145357|Dermacoccaceae 201174|Actinobacteria G Bacterial extracellular solute-binding protein - - - ko:K15770 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - SBP_bac_8 k59_898303_2 1408422.JHYF01000004_gene1553 3.67e-201 564.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36DYU@31979|Clostridiaceae 186801|Clostridia P Belongs to the ABC transporter superfamily msmX - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_1028473_1 1415779.JOMH01000001_gene1003 4.37e-51 171.0 COG3239@1|root,COG3239@2|Bacteria,1MXTQ@1224|Proteobacteria,1RRM8@1236|Gammaproteobacteria,1X5Q8@135614|Xanthomonadales 135614|Xanthomonadales I fatty acid desaturase - - - - - - - - - - - - - k59_796747_1 426355.Mrad2831_4121 2.91e-22 95.1 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,1JS0Z@119045|Methylobacteriaceae 28211|Alphaproteobacteria J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_796747_2 693986.MOC_0622 1.37e-79 245.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria,1JT0Y@119045|Methylobacteriaceae 28211|Alphaproteobacteria F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_539830_1 864069.MicloDRAFT_00063920 4.16e-19 84.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,1JSYF@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_539830_2 1123511.KB905853_gene3678 2.56e-05 51.2 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H2BH@909932|Negativicutes 909932|Negativicutes KLT serine threonine protein kinase prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_931589_1 102129.Lepto7375DRAFT_2011 1.37e-51 189.0 COG2909@1|root,COG2909@2|Bacteria,1G3UH@1117|Cyanobacteria,1HDU6@1150|Oscillatoriales 1117|Cyanobacteria K transcriptional regulator - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE k59_244373_1 1123261.AXDW01000010_gene423 1.64e-52 176.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1X3P6@135614|Xanthomonadales 135614|Xanthomonadales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_898314_1 722419.PH505_ad00140 1.15e-12 75.1 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2PZDP@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_113967_1 765912.Thimo_0558 2.62e-60 192.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1WWMS@135613|Chromatiales 135613|Chromatiales I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_670476_1 411464.DESPIG_01864 9.17e-74 244.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2M9DU@213115|Desulfovibrionales 28221|Deltaproteobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_507676_1 326298.Suden_0135 3.84e-208 595.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,42M9U@68525|delta/epsilon subdivisions,2YNJP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K RNA binding S1 domain protein - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_1028491_1 999611.KI421504_gene1258 8.49e-41 145.0 COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2TUQ5@28211|Alphaproteobacteria,27ZYD@191028|Leisingera 28211|Alphaproteobacteria S DMSO reductase anchor subunit (DmsC) dmsC - - ko:K21309 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - DmsC k59_865061_1 1537917.JU82_00250 2.13e-82 253.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2YMCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kpsF - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_931603_1 1121373.KB903664_gene2643 2.45e-93 286.0 COG1262@1|root,COG1262@2|Bacteria,4NFR2@976|Bacteroidetes,47KU9@768503|Cytophagia 976|Bacteroidetes S Sulfatase-modifying factor enzyme 1 - - 1.8.3.7 ko:K13444 ko04142,map04142 - - - ko00000,ko00001,ko01000 - - - FGE-sulfatase k59_931603_2 1168034.FH5T_08275 7.04e-122 371.0 COG1882@1|root,COG1882@2|Bacteria,4NDWW@976|Bacteroidetes,2FMC2@200643|Bacteroidia 976|Bacteroidetes C Psort location Cytoplasmic, score 9.97 - - 2.3.1.54,4.1.1.83 ko:K00656,ko:K18427 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_733814_1 1442598.JABW01000003_gene120 4.19e-72 228.0 COG3504@1|root,COG3504@2|Bacteria,1MVHJ@1224|Proteobacteria,42MUV@68525|delta/epsilon subdivisions,2YNDB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Conjugal transfer protein - - - ko:K03204 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - CagX k59_275644_1 502025.Hoch_4148 1.79e-78 249.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2WJZA@28221|Deltaproteobacteria,2YZ8X@29|Myxococcales 28221|Deltaproteobacteria U Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_46672_1 765911.Thivi_1903 4.43e-138 413.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_637432_1 1304883.KI912532_gene1874 1.19e-26 108.0 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1R53C@1224|Proteobacteria,2VNCZ@28216|Betaproteobacteria,2KW0J@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_81001_1 118173.KB235910_gene4327 6.21e-58 193.0 COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1H8SW@1150|Oscillatoriales 1117|Cyanobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_996921_1 1121289.JHVL01000039_gene3115 7.09e-47 164.0 COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,36EVZ@31979|Clostridiaceae 186801|Clostridia T carbon starvation protein CstA cstA - - - - - - - - - - - CstA,CstA_5TM k59_1028504_1 1144305.PMI02_04518 4.81e-219 618.0 COG3515@1|root,COG3515@2|Bacteria,1NRMK@1224|Proteobacteria 1224|Proteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_10624_1 153721.MYP_5011 2.99e-32 128.0 COG0358@1|root,COG0630@1|root,COG0358@2|Bacteria,COG0630@2|Bacteria,4NI2W@976|Bacteroidetes,47NGY@768503|Cytophagia 976|Bacteroidetes LNU type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_1028510_1 376686.Fjoh_4093 5.46e-104 317.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,1I007@117743|Flavobacteriia,2NUYI@237|Flavobacterium 976|Bacteroidetes G Pectate lyase - - - - - - - - - - - - - k59_832941_1 400682.PAC_15704268 2.21e-58 193.0 COG0464@1|root,KOG0730@2759|Eukaryota,3AKJP@33154|Opisthokonta 33154|Opisthokonta O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_472976_1 1537917.JU82_11285 4.51e-40 144.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2YM8S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_472976_2 1537917.JU82_11280 8.41e-22 95.5 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2YMFX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N_3 k59_637443_1 395493.BegalDRAFT_3404 3.12e-54 180.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,460J5@72273|Thiotrichales 72273|Thiotrichales M PFAM Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_637444_1 237368.SCABRO_01747 1.93e-78 243.0 COG1943@1|root,COG1943@2|Bacteria,2J13K@203682|Planctomycetes 203682|Planctomycetes L Transposase IS200 like - - - - - - - - - - - - - k59_767570_1 7209.EFO12873.1 5.04e-06 51.6 COG0531@1|root,KOG2082@2759|Eukaryota,38E2I@33154|Opisthokonta,3BBDS@33208|Metazoa,3CTA6@33213|Bilateria,40BS2@6231|Nematoda,1KV4A@119089|Chromadorea 33208|Metazoa P Solute carrier family 12 - GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006820,GO:0006821,GO:0006865,GO:0007154,GO:0007267,GO:0007268,GO:0007610,GO:0007638,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009605,GO:0009612,GO:0009628,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015103,GO:0015108,GO:0015171,GO:0015291,GO:0015293,GO:0015294,GO:0015296,GO:0015318,GO:0015377,GO:0015379,GO:0015672,GO:0015698,GO:0015711,GO:0015849,GO:0022804,GO:0022857,GO:0022890,GO:0023052,GO:0030001,GO:0030424,GO:0034220,GO:0036477,GO:0042995,GO:0043005,GO:0043025,GO:0044297,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071804,GO:0071805,GO:0097458,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:0098916,GO:0099536,GO:0099537,GO:0120025,GO:1902476,GO:1903825,GO:1905039 - ko:K14427 - - - - ko00000,ko02000 2.A.30.5 - - AA_permease,SLC12 k59_996945_1 1249480.B649_02160 7.61e-188 526.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,42N99@68525|delta/epsilon subdivisions,2YMDU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_996945_2 709032.Sulku_0440 2.63e-59 191.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,42MY7@68525|delta/epsilon subdivisions,2YMP6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_344033_2 998674.ATTE01000001_gene1965 2.84e-12 69.7 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1T58V@1236|Gammaproteobacteria,463WP@72273|Thiotrichales 1236|Gammaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_670507_1 1121422.AUMW01000038_gene3022 4.08e-114 340.0 COG3259@1|root,COG3259@2|Bacteria,1UZNV@1239|Firmicutes,24F0H@186801|Clostridia 186801|Clostridia C PFAM Nickel-dependent hydrogenase, large subunit - - 1.8.98.5 ko:K14126 ko00680,map00680 - R00019,R11943 RC00011 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_996947_1 572544.Ilyop_1185 1.52e-60 191.0 COG0476@1|root,COG0476@2|Bacteria,379ZW@32066|Fusobacteria 32066|Fusobacteria H ThiF family thiF - 2.7.7.73 ko:K03148 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_996947_2 572544.Ilyop_1186 7.19e-26 100.0 COG0352@1|root,COG0352@2|Bacteria,37954@32066|Fusobacteria 32066|Fusobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_81018_1 709032.Sulku_2500 1.33e-40 139.0 COG0352@1|root,COG0352@2|Bacteria,1P3Q4@1224|Proteobacteria,42SIF@68525|delta/epsilon subdivisions,2YPJ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H thiamine-phosphate diphosphorylase activity - - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - - k59_81018_2 387093.SUN_0039 6.73e-111 325.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2YMEM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_148532_1 204669.Acid345_1077 2.95e-37 141.0 COG0317@1|root,COG0317@2|Bacteria,3Y6MC@57723|Acidobacteria,2JKUM@204432|Acidobacteriia 204432|Acidobacteriia KT HD domain - - - - - - - - - - - - HD_4 k59_114921_1 886293.Sinac_2330 6.84e-13 70.9 COG0526@1|root,COG0526@2|Bacteria,2J0JE@203682|Planctomycetes 203682|Planctomycetes CO COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_114921_2 1122139.KB907883_gene324 7.42e-08 54.7 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1XHDQ@135619|Oceanospirillales 135619|Oceanospirillales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_964535_1 1408473.JHXO01000008_gene2648 1.61e-94 297.0 COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes,2FMEB@200643|Bacteroidia 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_734696_1 326298.Suden_1519 2.3e-65 209.0 COG3391@1|root,COG3391@2|Bacteria,1QUIK@1224|Proteobacteria,42RTQ@68525|delta/epsilon subdivisions,2YPA4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S amine dehydrogenase activity napL - - - - - - - - - - - - k59_276484_1 439235.Dalk_2268 2.62e-56 189.0 COG4191@1|root,COG4191@2|Bacteria,1R682@1224|Proteobacteria,42P91@68525|delta/epsilon subdivisions,2WKQI@28221|Deltaproteobacteria,2MJEK@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9 k59_703207_1 1187851.A33M_1080 1.88e-75 242.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,3FCTW@34008|Rhodovulum 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_964541_1 641491.DND132_3093 1.28e-79 245.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2MEMH@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - DmsC,Fer4_11,Fer4_4 k59_245225_1 1454004.AW11_02363 2.95e-09 56.2 COG1961@1|root,COG1961@2|Bacteria,1MXXT@1224|Proteobacteria,2VK5K@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Resolvase - - - - - - - - - - - - Resolvase k59_81883_1 314230.DSM3645_11237 2.64e-19 87.8 COG3119@1|root,COG3119@2|Bacteria,2IX9T@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - DUF4976,Sulfatase k59_81883_2 1042376.AFPK01000074_gene2381 7.77e-06 51.2 COG3119@1|root,COG3119@2|Bacteria,4NGJU@976|Bacteroidetes,1I7IS@117743|Flavobacteriia 976|Bacteroidetes P Sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_508450_1 1049564.TevJSym_aj00380 1.06e-14 72.4 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1J4C3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_508450_2 85643.Tmz1t_3434 5.25e-19 81.3 COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,2KWVG@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_508450_3 1123261.AXDW01000010_gene415 7.5e-08 55.1 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1X3X2@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_605799_1 882083.SacmaDRAFT_0264 5.01e-84 269.0 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4E0ZF@85010|Pseudonocardiales 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_605804_1 1347086.CCBA010000003_gene3934 1.27e-44 160.0 COG4974@1|root,COG4974@2|Bacteria,1UA9R@1239|Firmicutes,4HFKY@91061|Bacilli,1ZE7N@1386|Bacillus 91061|Bacilli L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_5,Phage_integrase k59_865954_1 469617.FUAG_01258 4.14e-79 251.0 COG4468@1|root,COG4468@2|Bacteria,378V1@32066|Fusobacteria 32066|Fusobacteria G Galactose-1-phosphate uridyl transferase, C-terminal domain galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf k59_768325_1 754436.JCM19237_4369 1.14e-33 128.0 COG4461@1|root,COG4461@2|Bacteria,1R6Q3@1224|Proteobacteria,1S2QD@1236|Gammaproteobacteria 1236|Gammaproteobacteria G protein conserved in bacteria - - - - - - - - - - - - LprI,MliC k59_797603_1 751994.AGIG01000035_gene356 7.93e-69 221.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RRHA@1236|Gammaproteobacteria,1JA2H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_376290_3 387092.NIS_0181 5.13e-70 225.0 COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42Q7W@68525|delta/epsilon subdivisions,2YQ1A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Glycosyl transferase family 21 - - - ko:K11936 ko02026,map02026 - - - ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.2,4.D.1.1.3 GT2 - Glyco_tranf_2_3 k59_997811_1 869213.JCM21142_104360 1.78e-144 422.0 COG0369@1|root,COG1151@2|Bacteria,4NGRB@976|Bacteroidetes 976|Bacteroidetes C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k59_310034_1 768671.ThimaDRAFT_3169 6.09e-34 124.0 2ESM0@1|root,33K5K@2|Bacteria,1N02H@1224|Proteobacteria,1SA2K@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_47443_2 1165841.SULAR_10549 1.95e-22 96.7 COG0475@1|root,COG0475@2|Bacteria,1RFKE@1224|Proteobacteria,43B2P@68525|delta/epsilon subdivisions,2YT5F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_932460_1 1238450.VIBNISOn1_30151 0.000282 50.4 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,1XV5E@135623|Vibrionales 135623|Vibrionales M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_276516_1 1265503.KB905166_gene652 3.01e-39 159.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_81897_1 1298593.TOL_1305 5.1e-12 71.6 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,1XI6K@135619|Oceanospirillales 135619|Oceanospirillales T 7TMR-DISM extracellular 2 - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF k59_1029303_1 1027273.GZ77_10370 1.8e-49 171.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,1XIS5@135619|Oceanospirillales 135619|Oceanospirillales C alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_473763_1 1174528.JH992898_gene977 1.28e-56 194.0 COG5421@1|root,COG5421@2|Bacteria,1G3YW@1117|Cyanobacteria 1117|Cyanobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_605815_2 536233.CLO_3007 3.03e-56 189.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,36DUZ@31979|Clostridiaceae 186801|Clostridia E Aminotransferase aspB - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS06550 Aminotran_1_2 k59_276530_1 1168034.FH5T_12885 7.55e-83 246.0 COG0096@1|root,COG0096@2|Bacteria,4NNFW@976|Bacteroidetes,2FRZ6@200643|Bacteroidia 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_276530_2 1168034.FH5T_12890 9.8e-53 170.0 COG0097@1|root,COG0097@2|Bacteria,4NGJM@976|Bacteroidetes,2FNEG@200643|Bacteroidia 976|Bacteroidetes J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_344914_1 221988.MS0658 1.42e-70 216.0 COG0615@1|root,COG0615@2|Bacteria,1RAJP@1224|Proteobacteria,1S65A@1236|Gammaproteobacteria,1Y9MD@135625|Pasteurellales 135625|Pasteurellales IM Cytidylyltransferase-like - - 2.7.7.39 ko:K00980 ko00564,map00564 - R00856 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like k59_833813_1 472759.Nhal_0484 1.06e-59 202.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_11457_1 1499683.CCFF01000017_gene2844 4.84e-105 315.0 COG0524@1|root,COG0524@2|Bacteria,1TQ9Q@1239|Firmicutes,25B0T@186801|Clostridia,36WFM@31979|Clostridiaceae 186801|Clostridia G pfkB family carbohydrate kinase - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_932470_1 387093.SUN_0689 3.51e-33 131.0 COG1538@1|root,COG1538@2|Bacteria,1Q5ZE@1224|Proteobacteria,42V2A@68525|delta/epsilon subdivisions,2YQ6A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU COG1538 Outer membrane protein - - - - - - - - - - - - OEP k59_708474_2 1332071.L581_2432 1.83e-80 247.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RP6D@1236|Gammaproteobacteria,4029F@613|Serratia 1236|Gammaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_643586_1 35720.XP_003651999.1 2.64e-51 183.0 COG0002@1|root,COG0548@1|root,KOG2436@2759|Eukaryota,KOG4354@2759|Eukaryota,38FTK@33154|Opisthokonta,3NW51@4751|Fungi,3QK90@4890|Ascomycota,2117P@147550|Sordariomycetes,3U6P8@5139|Sordariales,3HB6D@35718|Chaetomiaceae 4751|Fungi E belongs to the acetylglutamate kinase family 6 GO:0003674,GO:0003824,GO:0003942,GO:0003991,GO:0004042,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006355,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016491,GO:0016597,GO:0016620,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0016903,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0031406,GO:0031974,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055114,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903506,GO:2000112,GO:2001141 1.2.1.38,2.7.2.8 ko:K12659 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649,R03443 RC00002,RC00043,RC00684 ko00000,ko00001,ko00002,ko01000 - - iMM904.YER069W,iND750.YER069W AA_kinase,NAT,Semialdhyde_dh,Semialdhyde_dhC k59_381642_1 1304866.K413DRAFT_5149 2.8e-90 283.0 COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,36DHY@31979|Clostridiaceae 186801|Clostridia J elongation factor G tetM - - ko:K18220 - - - - br01600,ko00000,ko01504 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_120451_1 1449126.JQKL01000039_gene1064 2.22e-46 165.0 COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,268EF@186813|unclassified Clostridiales 186801|Clostridia P Cation transport protein trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_16895_1 1449353.JQMQ01000005_gene1467 1.88e-12 67.0 COG1403@1|root,COG1403@2|Bacteria,2GMJV@201174|Actinobacteria,2NHE5@228398|Streptacidiphilus 201174|Actinobacteria V HNH endonuclease - - - - - - - - - - - - HNH,HNH_5 k59_676946_2 795955.AFRW01000015_gene1694 3.72e-14 77.8 COG0637@1|root,COG3021@1|root,COG0637@2|Bacteria,COG3021@2|Bacteria,2I362@201174|Actinobacteria,1W9IZ@1268|Micrococcaceae 201174|Actinobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_708481_1 572544.Ilyop_1901 5.13e-117 370.0 COG1197@1|root,COG1197@2|Bacteria,378H0@32066|Fusobacteria 32066|Fusobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_16896_1 1297865.APJD01000006_gene4324 1.7e-23 98.2 COG2267@1|root,COG2267@2|Bacteria,1PIJ1@1224|Proteobacteria,2U2FG@28211|Alphaproteobacteria,3JUWG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_1003146_1 999550.KI421507_gene38 3.72e-60 193.0 COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,2U1ES@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ KR domain fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_87337_1 1168034.FH5T_04015 2e-91 299.0 COG4797@1|root,COG4797@2|Bacteria,4PKQS@976|Bacteroidetes,2FP69@200643|Bacteroidia 976|Bacteroidetes S Motility related/secretion protein sprA - - - - - - - - - - - SprA_N k59_1003994_2 765914.ThisiDRAFT_1131 1.04e-24 115.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1WVZW@135613|Chromatiales 135613|Chromatiales NU Type II and III secretion system protein - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_514745_1 159087.Daro_3314 1.54e-05 46.2 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,2KUSX@206389|Rhodocyclales 206389|Rhodocyclales C FAD binding glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_514745_2 1231391.AMZF01000032_gene643 8.04e-41 147.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,3T1NU@506|Alcaligenaceae 28216|Betaproteobacteria C Glycolate oxidase iron-sulfur subunit glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_154727_1 118163.Ple7327_1851 1.63e-43 161.0 COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1GQTV@1117|Cyanobacteria 1117|Cyanobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_578768_1 391735.Veis_3398 8.66e-144 426.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,4AA6N@80864|Comamonadaceae 28216|Betaproteobacteria I Methylmalonyl-CoA mutase large subunit icmF - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_154728_1 1492737.FEM08_17840 4.55e-69 226.0 COG1070@1|root,COG1070@2|Bacteria,4NIJC@976|Bacteroidetes 976|Bacteroidetes G Carbohydrate kinase, FGGY family protein rhaB GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 2.7.1.5,2.7.1.51 ko:K00848,ko:K00879 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01902,R03014,R03241 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_546366_1 411154.GFO_3525 8.49e-19 89.0 28M5H@1|root,2ZAJ9@2|Bacteria,4NESS@976|Bacteroidetes,1HZDQ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_480006_1 270374.MELB17_01660 3.71e-25 97.4 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,46779@72275|Alteromonadaceae 1236|Gammaproteobacteria S metal-binding protein copG - - - - - - - - - - - DUF411 k59_480006_2 472759.Nhal_1702 2.14e-13 66.2 COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1TKC3@1236|Gammaproteobacteria,1X1RM@135613|Chromatiales 135613|Chromatiales S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_382392_1 637905.SVI_0955 6.76e-86 268.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,2QAN0@267890|Shewanellaceae 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_872118_1 1168034.FH5T_15270 8.32e-30 115.0 2BXG3@1|root,2Z82R@2|Bacteria,4NI3Z@976|Bacteroidetes,2FNWQ@200643|Bacteroidia 976|Bacteroidetes S tagaturonate epimerase - - 5.1.2.7 ko:K21619 ko00040,ko01100,map00040,map01100 - R11624 - ko00000,ko00001,ko01000 - - - UxaE k59_872118_2 1168034.FH5T_15265 5.35e-55 192.0 COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,2FM0P@200643|Bacteroidia 976|Bacteroidetes G beta-galactosidase - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_803854_1 561229.Dd1591_2741 4.78e-52 175.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1S0KW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Molecular chaperone GroES - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_803854_2 411474.COPEUT_02500 3.51e-13 68.9 COG0599@1|root,COG1917@1|root,COG0599@2|Bacteria,COG1917@2|Bacteria,1TRVH@1239|Firmicutes,249JY@186801|Clostridia 186801|Clostridia S conserved protein, contains double-stranded beta-helix domain - - - - - - - - - - - - CMD,Cupin_2 k59_839912_1 1168034.FH5T_18125 1.25e-58 195.0 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - - - - - - - - - - PQQ_2 k59_644448_1 387093.SUN_1021 2.18e-84 255.0 COG1191@1|root,COG1943@1|root,COG1191@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2YPQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Transposase - - - - - - - - - - - - Y1_Tnp k59_17824_1 765911.Thivi_1338 3.88e-78 249.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria,1WWS0@135613|Chromatiales 135613|Chromatiales P inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_17824_2 1123023.JIAI01000001_gene6691 0.000511 42.4 COG0410@1|root,COG0410@2|Bacteria,2IB16@201174|Actinobacteria,4E8TX@85010|Pseudonocardiales 201174|Actinobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_350992_1 1265313.HRUBRA_01492 4.04e-87 265.0 COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_611818_1 1165841.SULAR_02323 1.17e-79 250.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2YMQ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_53566_1 929558.SMGD1_1804 1.51e-91 282.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,42N4K@68525|delta/epsilon subdivisions,2YMVY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S HI0933 family - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_316104_1 326298.Suden_1695 1e-55 179.0 COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,42RIW@68525|delta/epsilon subdivisions,2YP6Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane-associated protein dedA - - - - - - - - - - - SNARE_assoc k59_414568_1 765912.Thimo_2264 1.14e-134 397.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales 135613|Chromatiales F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_677715_1 1304885.AUEY01000030_gene2429 1.02e-88 275.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MHV2@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_839926_1 1168034.FH5T_08455 2.27e-69 226.0 COG1983@1|root,COG1983@2|Bacteria,4NG3T@976|Bacteroidetes,2FPZX@200643|Bacteroidia 976|Bacteroidetes KT PspC domain protein - - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - DUF2807,PspC k59_644468_1 1121396.KB893080_gene896 1.77e-42 157.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42MBP@68525|delta/epsilon subdivisions,2WJAJ@28221|Deltaproteobacteria,2MHTN@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_351006_1 1168034.FH5T_03550 1.52e-54 184.0 COG1566@1|root,COG1566@2|Bacteria,4NH7M@976|Bacteroidetes,2FUVZ@200643|Bacteroidia 976|Bacteroidetes V Protein of unknown function (DUF3667) - - - - - - - - - - - - DUF3667 k59_187298_1 1265505.ATUG01000002_gene2688 3.5e-79 254.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2MIPZ@213118|Desulfobacterales 28221|Deltaproteobacteria C Phosphoenolpyruvate carboxykinase N-terminal domain pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2638 PEPCK_C,PEPCK_N k59_644476_1 1278306.KB906906_gene296 1.08e-45 160.0 COG3181@1|root,COG3181@2|Bacteria,37AES@32066|Fusobacteria 32066|Fusobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1035162_1 573061.Clocel_4240 2.32e-80 251.0 COG3401@1|root,COG3401@2|Bacteria,1VSGG@1239|Firmicutes,24AMB@186801|Clostridia,36F2R@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function - - - - - - - - - - - - DUF4990 k59_774567_1 1110502.TMO_0633 4.62e-93 278.0 COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,2JQ14@204441|Rhodospirillales 204441|Rhodospirillales E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_414587_1 765912.Thimo_2383 1.05e-38 138.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales 135613|Chromatiales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_414587_2 572477.Alvin_1893 1.01e-37 135.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1WWWT@135613|Chromatiales 135613|Chromatiales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_121204_1 1121456.ATVA01000011_gene1357 1.52e-72 240.0 COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2M7VM@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_546398_1 929558.SMGD1_2325 4.05e-61 201.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2YNFF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P transporter - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_546398_2 1172190.M947_00225 1.81e-45 155.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2YMSA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iIT341.HP0961 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_970807_1 1095769.CAHF01000011_gene2568 4.92e-07 56.6 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS,PAS_3 k59_740869_1 243231.GSU1290 6.32e-50 176.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,43S4S@69541|Desulfuromonadales 28221|Deltaproteobacteria T Signal transducing histidine kinase homodimeric cheA34H - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_1035170_1 393595.ABO_2540 1.13e-40 140.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,1XKPZ@135619|Oceanospirillales 135619|Oceanospirillales C cytochrome c5 - - - - - - - - - - - - Cytochrome_CBB3 k59_1035170_2 420662.Mpe_A2510 1.31e-30 123.0 COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KJDR@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_8,PAS_9,SBP_bac_3 k59_154792_1 1168034.FH5T_04685 2.13e-52 187.0 COG5000@1|root,COG5000@2|Bacteria,4NE49@976|Bacteroidetes,2FRVJ@200643|Bacteroidia 976|Bacteroidetes T COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation zraS_1 - - - - - - - - - - - HATPase_c,HisKA k59_872186_1 1120963.KB894494_gene3474 7.96e-66 223.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,2Q06W@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Bifunctional aspartokinase I homoserine dehydrogenase I thrA GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0002,iEcDH1_1363.EcDH1_3594,iSFV_1184.SFV_0001 AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_774588_1 572544.Ilyop_1257 1.54e-63 214.0 COG1762@1|root,COG3711@1|root,COG1762@2|Bacteria,COG3711@2|Bacteria,379DZ@32066|Fusobacteria 32066|Fusobacteria K PRD domain protein - - - - - - - - - - - - HTH_11,Mga,PRD,PTS_EIIA_2,PTS_IIB k59_905585_1 697282.Mettu_4268 4.36e-106 338.0 28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria,1XDZM@135618|Methylococcales 135618|Methylococcales S phosphoenolpyruvate carboxykinase (diphosphate) activity - - 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 - R00346 RC02741 ko00000,ko00001,ko01000 - - - - k59_414623_1 683083.C414_000160011 9.93e-50 179.0 COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,42N1G@68525|delta/epsilon subdivisions,2YME2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U COG3451 Type IV secretory pathway, VirB4 components cagE - - ko:K03199,ko:K12108 ko03070,ko05120,map03070,map05120 M00333,M00564 - - ko00000,ko00001,ko00002,ko02044 3.A.7,3.A.7.12.1 - - AAA_10,CagE_TrbE_VirB,VirB3 k59_970832_1 1168034.FH5T_09195 2.24e-101 317.0 COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,2FM1K@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug k59_154805_1 301.JNHE01000002_gene2187 4.79e-48 166.0 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1YD7T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S L,D-transpeptidase catalytic domain ycfS GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0034645,GO:0042546,GO:0042597,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070004,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K16291,ko:K19234,ko:K19235,ko:K19236 ko01503,map01503 - - - ko00000,ko00001,ko01002,ko01011 - - - LysM,YkuD k59_872198_1 1247963.JPHU01000021_gene18 7.29e-73 244.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_351044_1 1278309.KB907101_gene379 2.09e-21 99.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1XRT5@135619|Oceanospirillales 135619|Oceanospirillales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_17873_1 983920.Y88_3312 9.34e-40 145.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,2K1X6@204457|Sphingomonadales 204457|Sphingomonadales C FAD linked oxidases, C-terminal domain - - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_803913_1 742823.HMPREF9465_00624 1.42e-53 181.0 COG2021@1|root,COG2021@2|Bacteria,1QU6N@1224|Proteobacteria,2WGNS@28216|Betaproteobacteria,4PS3G@995019|Sutterellaceae 28216|Betaproteobacteria E Alpha/beta hydrolase family - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_803913_2 1123256.KB907925_gene1423 1.36e-36 136.0 COG1020@1|root,COG1020@2|Bacteria,1R70N@1224|Proteobacteria,1RZDY@1236|Gammaproteobacteria,1X4RB@135614|Xanthomonadales 135614|Xanthomonadales Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_480064_1 1280685.AUKC01000048_gene3055 4.35e-55 186.0 COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,4BYGF@830|Butyrivibrio 186801|Clostridia J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_514802_2 766499.C357_04527 6.17e-35 128.0 COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain alaS2 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K07050 - - - - ko00000,ko01000,ko03016 - - - tRNA-synt_2c,tRNA_SAD k59_154813_1 1278073.MYSTI_05584 1.08e-171 496.0 COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,42ZIG@68525|delta/epsilon subdivisions,2WUZE@28221|Deltaproteobacteria,2YX8Y@29|Myxococcales 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_282711_1 709032.Sulku_0381 6.6e-156 454.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2YMRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_905592_1 929558.SMGD1_0149 1.2e-81 259.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2YN0E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the UbiD family menA - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0396 UbiD k59_970843_2 546271.Selsp_2063 1.2e-67 215.0 COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,4H20B@909932|Negativicutes 909932|Negativicutes KT response regulator arlR - - - - - - - - - - - Response_reg,Trans_reg_C k59_578840_1 1168034.FH5T_04225 1.46e-50 161.0 COG1544@1|root,COG1544@2|Bacteria,4NUME@976|Bacteroidetes,2FTZJ@200643|Bacteroidia 976|Bacteroidetes J ribosomal subunit interface protein raiA - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_578840_2 1408473.JHXO01000006_gene1407 2.43e-65 208.0 COG4974@1|root,COG4974@2|Bacteria,4NGQW@976|Bacteroidetes,2FNFK@200643|Bacteroidia 976|Bacteroidetes L Belongs to the 'phage' integrase family xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_480073_1 583355.Caka_2045 3.22e-98 322.0 COG0771@1|root,COG2911@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity murD - 3.4.21.10,6.3.2.13,6.3.2.9 ko:K01317,ko:K01925,ko:K01928,ko:K01932 ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100 - R02783,R02788 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01002,ko01011,ko04131 - - - DUF1727,Mur_ligase_C,Mur_ligase_M k59_17890_1 519989.ECTPHS_01379 3.87e-97 293.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_17890_2 870187.Thini_3225 8.94e-11 62.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4607S@72273|Thiotrichales 72273|Thiotrichales T nitrogen regulation protein NR(I) - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_803929_1 631362.Thi970DRAFT_01906 1.24e-68 223.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales 135613|Chromatiales G PFAM glycoside hydrolase, family 77 - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_59306_3 153948.NAL212_0064 5.88e-05 46.2 COG2963@1|root,COG2963@2|Bacteria,1QWAU@1224|Proteobacteria,2W69R@28216|Betaproteobacteria,374FJ@32003|Nitrosomonadales 28216|Betaproteobacteria L transposase activity - - - - - - - - - - - - HTH_Tnp_1 k59_844794_1 330214.NIDE0779 9.49e-51 179.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_225192_1 279714.FuraDRAFT_2888 9.28e-42 149.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,2KQDY@206351|Neisseriales 206351|Neisseriales S Displays ATPase and GTPase activities yhbJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_225192_2 225937.HP15_2444 3.9e-12 65.1 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,46810@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) ptsN GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008047,GO:0008150,GO:0008643,GO:0009401,GO:0009893,GO:0010033,GO:0010243,GO:0010562,GO:0010604,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032879,GO:0033674,GO:0034219,GO:0034762,GO:0034765,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071944,GO:0080090,GO:0090563,GO:0098772,GO:1901698 - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_1041282_1 1537917.JU82_06385 1.89e-46 156.0 COG1579@1|root,COG1579@2|Bacteria,1R7GT@1224|Proteobacteria,42P3S@68525|delta/epsilon subdivisions,2YMAN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG1579 Zn-ribbon protein possibly nucleic acid-binding - - 3.5.4.16 ko:K07164,ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - zf-RING_7 k59_389002_1 1415780.JPOG01000001_gene2394 6.51e-231 645.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1X35C@135614|Xanthomonadales 135614|Xanthomonadales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_453627_1 631362.Thi970DRAFT_04753 3.82e-96 296.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_389006_1 1265505.ATUG01000001_gene2968 8.93e-12 64.3 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,42NSB@68525|delta/epsilon subdivisions,2WIKP@28221|Deltaproteobacteria,2MJ70@213118|Desulfobacterales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_389006_2 1121405.dsmv_3527 1.44e-46 161.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,42PDT@68525|delta/epsilon subdivisions,2WKER@28221|Deltaproteobacteria,2MIIP@213118|Desulfobacterales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_975727_2 2340.JV46_11260 8.18e-34 120.0 COG0346@1|root,COG0346@2|Bacteria,1RIR2@1224|Proteobacteria,1S7P4@1236|Gammaproteobacteria,1J6FS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_617553_1 864069.MicloDRAFT_00060880 2.02e-28 118.0 COG0421@1|root,COG0421@2|Bacteria,1QVKE@1224|Proteobacteria,2U21Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_389011_1 2340.JV46_22540 2.33e-85 276.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1J57N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_453638_1 387093.SUN_2218 4.4e-127 376.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2YNBN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_59318_1 1379281.AVAG01000077_gene1605 2.04e-76 248.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2M882@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_256939_1 1168034.FH5T_10365 6.73e-77 234.0 2EUVH@1|root,33NAZ@2|Bacteria,4NXNT@976|Bacteroidetes,2FZE7@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_484742_1 1150600.ADIARSV_2339 2.68e-56 193.0 COG3064@1|root,COG3064@2|Bacteria 2|Bacteria M translation initiation factor activity - - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - ABC_tran k59_584568_1 1151127.KB906331_gene3261 9.86e-12 67.8 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1YRZ2@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria MU Transporter - - - - - - - - - - - - OEP k59_584568_2 667014.Thein_0138 2.89e-51 171.0 COG1309@1|root,COG1309@2|Bacteria,2GIHE@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K Domain of unknown function (DUF1956) - - - - - - - - - - - - DUF1956,TetR_N k59_910518_1 1325130.HFN_2208 4.27e-44 147.0 COG1699@1|root,COG1699@2|Bacteria,1N347@1224|Proteobacteria,42RNU@68525|delta/epsilon subdivisions,2YQ0C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW k59_910518_2 387093.SUN_1761 1.56e-39 139.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2YNFY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_552650_1 1049564.TevJSym_ab00440 2.92e-194 559.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter sac1 - - - - - - - - - - - CitMHS,TrkA_C k59_23352_1 765912.Thimo_3513 9.95e-85 258.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_944073_1 1131553.JIBI01000017_gene577 6.93e-161 484.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VJSI@28216|Betaproteobacteria,372PZ@32003|Nitrosomonadales 28216|Betaproteobacteria L RNA polymerase recycling family C-terminal - - - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - DUF3883,Helicase_C,RapA_C,ResIII,SNF2_N k59_356203_1 367737.Abu_0813 4.05e-153 463.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YM7R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Efflux pump membrane transporter - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_356203_2 90813.JQMT01000001_gene362 3.12e-57 197.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,460GN@72273|Thiotrichales 72273|Thiotrichales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_D23 k59_356203_4 1165841.SULAR_09704 5.02e-52 173.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2YMD5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_877398_1 392499.Swit_3856 4.24e-36 134.0 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2U5M0@28211|Alphaproteobacteria,2KEAE@204457|Sphingomonadales 204457|Sphingomonadales EGP of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_877398_2 631362.Thi970DRAFT_01520 2.67e-54 175.0 2DX2X@1|root,32V2M@2|Bacteria,1MZZC@1224|Proteobacteria,1S4WN@1236|Gammaproteobacteria,1WYAX@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_484748_1 69395.JQLZ01000001_gene2708 1.82e-108 330.0 COG1331@1|root,COG1331@2|Bacteria,1R570@1224|Proteobacteria,2TUBQ@28211|Alphaproteobacteria,2KFKA@204458|Caulobacterales 204458|Caulobacterales O Pectic acid lyase - - - - - - - - - - - - Pec_lyase k59_192989_1 1121405.dsmv_3573 1.46e-44 148.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales 28221|Deltaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_192989_2 1121405.dsmv_3572 3.04e-24 92.4 COG1841@1|root,COG1841@2|Bacteria,1PU2T@1224|Proteobacteria,42WNP@68525|delta/epsilon subdivisions,2WRZZ@28221|Deltaproteobacteria,2MM1B@213118|Desulfobacterales 28221|Deltaproteobacteria J Ribosomal protein L30p/L7e rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_192989_3 350688.Clos_0511 1.25e-09 56.2 COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,36I11@31979|Clostridiaceae 186801|Clostridia J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_320820_1 1123354.AUDR01000013_gene721 3.3e-86 281.0 COG1061@1|root,COG1061@2|Bacteria,1MX92@1224|Proteobacteria,2VP2T@28216|Betaproteobacteria,1KT1V@119069|Hydrogenophilales 119069|Hydrogenophilales KL Type III restriction enzyme, res subunit - - 3.1.21.5 ko:K01156 - - - - ko00000,ko01000,ko02048 - - - ResIII k59_520500_1 526218.Sterm_1020 2.21e-95 291.0 COG0079@1|root,COG0079@2|Bacteria,378HR@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_520500_3 526218.Sterm_1022 6.16e-136 393.0 COG0181@1|root,COG0181@2|Bacteria,378HI@32066|Fusobacteria 32066|Fusobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_780125_1 497321.C664_04996 4.75e-70 216.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2VT25@28216|Betaproteobacteria 28216|Betaproteobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_780125_2 472759.Nhal_1059 1.36e-25 102.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S48C@1236|Gammaproteobacteria,1X28M@135613|Chromatiales 135613|Chromatiales J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1009040_1 926550.CLDAP_19740 7.22e-11 68.6 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi 200795|Chloroflexi C FAD linked oxidase domain protein - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8 k59_256968_1 1168034.FH5T_19100 1.39e-57 199.0 COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,4NI98@976|Bacteroidetes,2FPEX@200643|Bacteroidia 976|Bacteroidetes KT SpoIIE domain protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,HATPase_c_2,SpoIIE,dCache_1 k59_193002_1 694427.Palpr_2955 3.89e-60 210.0 COG4096@1|root,COG4096@2|Bacteria,4NH89@976|Bacteroidetes,2FQAV@200643|Bacteroidia,22XEH@171551|Porphyromonadaceae 976|Bacteroidetes L EcoEI R protein C-terminal - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF4145,EcoEI_R_C,HSDR_N,Helicase_C,ResIII k59_256969_1 296591.Bpro_4334 2.69e-91 278.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,4ABVU@80864|Comamonadaceae 28216|Betaproteobacteria L Integrase, catalytic region - - - - - - - - - - - - HTH_38,rve k59_910548_1 398767.Glov_1685 3.1e-10 59.7 COG1433@1|root,COG1433@2|Bacteria,1N7IQ@1224|Proteobacteria,42WGA@68525|delta/epsilon subdivisions,2WS2U@28221|Deltaproteobacteria,43VG7@69541|Desulfuromonadales 28221|Deltaproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_682957_1 1121904.ARBP01000009_gene4309 1.22e-51 169.0 COG2391@1|root,COG2391@2|Bacteria,4NGS1@976|Bacteroidetes 976|Bacteroidetes S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_682957_2 1250005.PHEL85_2145 3.66e-10 58.9 COG2391@1|root,COG2391@2|Bacteria,4NMK0@976|Bacteroidetes,1I1SD@117743|Flavobacteriia 976|Bacteroidetes S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_552679_1 768671.ThimaDRAFT_4701 5.62e-61 207.0 COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_780147_1 1168034.FH5T_05515 2.87e-114 338.0 COG0304@1|root,COG0304@2|Bacteria,4NEKC@976|Bacteroidetes,2FNDB@200643|Bacteroidia 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_844849_1 469616.FMAG_00785 2.07e-99 310.0 COG0209@1|root,COG0209@2|Bacteria,378A9@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC k59_617631_1 215803.DB30_1051 3.34e-24 106.0 COG0457@1|root,COG0515@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2YU18@29|Myxococcales 28221|Deltaproteobacteria KLT Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc,Pkinase k59_808954_1 565045.NOR51B_1736 8.81e-52 187.0 COG0642@1|root,COG0834@1|root,COG4251@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T1YP@1236|Gammaproteobacteria,1JC2G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Hpt domain - - - - - - - - - - - - 4HB_MCP_1,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_23392_1 379731.PST_0668 4.06e-83 260.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1Z33S@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_453715_1 1042377.AFPJ01000023_gene664 4.02e-39 149.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,46DC5@72275|Alteromonadaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_160951_1 1168034.FH5T_00675 2.33e-101 298.0 COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,2FPB3@200643|Bacteroidia 976|Bacteroidetes V ABC transporter, ATP-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_160951_2 1168034.FH5T_00670 9.48e-15 73.6 COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes,2FN2G@200643|Bacteroidia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_808957_1 1168034.FH5T_10545 1.46e-241 677.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,4NECB@976|Bacteroidetes,2FNV6@200643|Bacteroidia 976|Bacteroidetes J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_975780_1 1121035.AUCH01000009_gene918 1.04e-58 192.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,2KUQH@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_617646_1 709032.Sulku_0720 2.41e-09 58.5 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,43BJ2@68525|delta/epsilon subdivisions,2YN49@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II and III secretion system protein ctsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - STN,Secretin,Secretin_N_2 k59_584606_1 1218103.CIN01S_02_02880 3.58e-111 346.0 COG2189@1|root,COG2189@2|Bacteria,4NFKE@976|Bacteroidetes,1HYXQ@117743|Flavobacteriia,3ZR5Z@59732|Chryseobacterium 976|Bacteroidetes L Type III restriction/modification enzyme methylation subunit - - 2.1.1.72 ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase,TypeIII_RM_meth k59_584606_3 489653.NLA_12220 1.12e-294 845.0 COG3421@1|root,COG3421@2|Bacteria,1MWD2@1224|Proteobacteria,2W0RE@28216|Betaproteobacteria,2KSRA@206351|Neisseriales 206351|Neisseriales S Type III restriction modification system enzyme - - 3.1.21.5 ko:K01156 - - - - ko00000,ko01000,ko02048 - - - - k59_584606_4 32024.JMTI01000008_gene1159 1.68e-13 67.0 COG2033@1|root,COG2033@2|Bacteria,1Q2YB@1224|Proteobacteria,42WG8@68525|delta/epsilon subdivisions,2YQJS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Desulfoferrodoxin - - - - - - - - - - - - Desulfoferrodox k59_844860_1 1473546.CH76_09555 2.4e-26 110.0 COG0155@1|root,COG1010@1|root,COG0155@2|Bacteria,COG1010@2|Bacteria,1TPJ7@1239|Firmicutes,4HCQ1@91061|Bacilli,3IVSU@400634|Lysinibacillus 91061|Bacilli H Cobalt-precorrin-3B C(17)-methyltransferase cbiH - 2.1.1.272 ko:K21479 ko00860,ko01100,map00860,map01100 - R11580 RC03479 ko00000,ko00001,ko01000 - - - NIR_SIR,TP_methylase k59_520527_1 493475.GARC_4235 7.29e-52 185.0 COG3356@1|root,COG3356@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Ceramidase_alk k59_976857_1 870187.Thini_2000 1.04e-81 247.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,462CF@72273|Thiotrichales 72273|Thiotrichales C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_193884_1 1249480.B649_09050 4.11e-51 182.0 COG0457@1|root,COG0457@2|Bacteria,1QV15@1224|Proteobacteria,42NKI@68525|delta/epsilon subdivisions,2YMKG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG0457 FOG TPR repeat pflB - - - - - - - - - - - TPR_16,TPR_2,TPR_6,TPR_8 k59_24192_1 1168034.FH5T_12025 4.9e-27 109.0 COG2972@1|root,COG2972@2|Bacteria,4NHG3@976|Bacteroidetes,2FUUQ@200643|Bacteroidia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c_5,His_kinase k59_24192_2 1168034.FH5T_12020 7.2e-66 206.0 COG4758@1|root,COG4758@2|Bacteria,4NQRE@976|Bacteroidetes,2FMXH@200643|Bacteroidia 976|Bacteroidetes S Cell wall-active antibiotics response 4TMS YvqF - - - - - - - - - - - - DUF2154 k59_161785_1 387093.SUN_1678 1.67e-50 177.0 COG4972@1|root,COG4972@2|Bacteria,1QA6M@1224|Proteobacteria,42NDB@68525|delta/epsilon subdivisions,2YMP2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Pilus assembly protein - - - - - - - - - - - - - k59_809913_1 572544.Ilyop_0340 7.97e-104 310.0 COG0137@1|root,COG0137@2|Bacteria,3788R@32066|Fusobacteria 32066|Fusobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1042238_1 760154.Sulba_1574 3.2e-65 211.0 COG0270@1|root,COG0270@2|Bacteria,1R59Y@1224|Proteobacteria,42Z5R@68525|delta/epsilon subdivisions,2YRE6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_618469_1 714961.BFZC1_18550 2.01e-06 52.0 COG4127@1|root,COG4127@2|Bacteria,1VGJH@1239|Firmicutes 1239|Firmicutes S Restriction endonuclease - - - - - - - - - - - - - k59_845686_1 1232437.KL662061_gene4206 1.21e-70 227.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2WJZA@28221|Deltaproteobacteria,2MJXH@213118|Desulfobacterales 28221|Deltaproteobacteria P Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_257763_1 1454004.AW11_00535 1.97e-85 266.0 COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,2VKTF@28216|Betaproteobacteria 28216|Betaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_390060_1 755732.Fluta_0131 1.12e-29 117.0 2A263@1|root,30QGN@2|Bacteria,4NMYV@976|Bacteroidetes,1I29B@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_781109_1 1172190.M947_07470 5.64e-79 247.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2YMQH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin biosynthesis moeA2 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_944936_2 1397528.Q671_10590 4.52e-41 138.0 COG3436@1|root,COG3436@2|Bacteria,1N7AY@1224|Proteobacteria,1SD05@1236|Gammaproteobacteria,1XM3Y@135619|Oceanospirillales 135619|Oceanospirillales L IS66 Orf2 like protein - - - - - - - - - - - - TnpB_IS66 k59_553457_1 998674.ATTE01000001_gene4264 1.02e-52 182.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,460G2@72273|Thiotrichales 72273|Thiotrichales J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_193905_1 477974.Daud_1920 8.2e-71 233.0 COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,24CA4@186801|Clostridia,260IP@186807|Peptococcaceae 186801|Clostridia S RmuC family rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_683790_1 506534.Rhein_1544 4.53e-47 173.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJE@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_521238_1 1165841.SULAR_06863 4.38e-65 207.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2YP1P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_521238_2 387093.SUN_2004 5.26e-33 117.0 29QY9@1|root,30BZ3@2|Bacteria,1QTGR@1224|Proteobacteria,42VBX@68525|delta/epsilon subdivisions,2YQ83@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_524790_1 1165841.SULAR_09179 1.53e-17 87.8 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K07648,ko:K07679 ko02020,ko02026,ko05133,map02020,map02026,map05133 M00456,M00477 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 7TMR-DISM_7TM,GAF_2,HATPase_c,HisKA,Hpt,PAS,Response_reg k59_753475_1 290512.Paes_1558 1.52e-37 133.0 2EF9K@1|root,3392I@2|Bacteria,1FE95@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - k59_328752_1 879212.DespoDRAFT_00571 1.67e-28 118.0 COG2202@1|root,COG3852@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria,43DBR@68525|delta/epsilon subdivisions,2X8HR@28221|Deltaproteobacteria,2MPNM@213118|Desulfobacterales 28221|Deltaproteobacteria T PAS fold - - - - - - - - - - - - HATPase_c,PAS_9 k59_230627_1 749222.Nitsa_0345 2.39e-06 53.1 COG3209@1|root,COG3209@2|Bacteria,1R0C4@1224|Proteobacteria,43CUG@68525|delta/epsilon subdivisions 1224|Proteobacteria M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - - k59_851767_1 1168034.FH5T_09665 4.19e-27 110.0 COG0465@1|root,COG0465@2|Bacteria,4NF0E@976|Bacteroidetes,2FNEA@200643|Bacteroidia 976|Bacteroidetes O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_851767_2 1168034.FH5T_09670 1.03e-60 189.0 COG0799@1|root,COG0799@2|Bacteria,4NSKK@976|Bacteroidetes,2FSG4@200643|Bacteroidia 976|Bacteroidetes J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_720913_1 1165841.SULAR_04823 1.68e-65 209.0 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QYV@68525|delta/epsilon subdivisions,2YNW5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Jag_N - - - ko:K06346 - - - - ko00000 - - - Jag_N k59_818897_1 290402.Cbei_0446 4.82e-197 554.0 COG4806@1|root,COG4806@2|Bacteria,1TS42@1239|Firmicutes,2487G@186801|Clostridia,36HH0@31979|Clostridiaceae 186801|Clostridia G Belongs to the rhamnose isomerase family rhaA - 5.3.1.14 ko:K01813 ko00051,ko01120,map00051,map01120 - R02437 RC00434 ko00000,ko00001,ko01000 - - - RhaA k59_818897_2 478749.BRYFOR_06580 4.98e-148 438.0 COG1070@1|root,COG1070@2|Bacteria,1TP7Z@1239|Firmicutes,247ZU@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score rhaB - 2.7.1.5 ko:K00848 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01902,R03014 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_818897_3 1158606.I579_00241 1.35e-23 97.4 COG3090@1|root,COG3090@2|Bacteria,1V3SM@1239|Firmicutes,4HK4Y@91061|Bacilli,4B2P1@81852|Enterococcaceae 91061|Bacilli G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_818897_4 572544.Ilyop_0315 5.04e-36 135.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - Usp k59_361474_1 1229780.BN381_130081 6.85e-73 237.0 COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria 201174|Actinobacteria H Mg-chelatase subunit ChlI chlI - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - iNJ661.Rv0958 Mg_chelatase,Sigma54_activat k59_590167_2 697281.Mahau_1153 6.15e-45 163.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,42FFC@68295|Thermoanaerobacterales 186801|Clostridia C Part of a membrane complex involved in electron transport rnfC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,RnfC_N,SLBB k59_99791_1 1122138.AQUZ01000152_gene5379 8.48e-58 190.0 COG1961@1|root,COG1961@2|Bacteria 2|Bacteria L recombinase activity - - - - - - - - - - - - HTH_17,Recombinase,Resolvase,Zn_ribbon_recom k59_622801_2 387093.SUN_1046 9.01e-98 301.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2YMAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_66962_1 1123393.KB891316_gene1533 5.97e-174 495.0 COG0446@1|root,COG0446@2|Bacteria,1PVXQ@1224|Proteobacteria,2WBJS@28216|Betaproteobacteria,1KS2X@119069|Hydrogenophilales 119069|Hydrogenophilales S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_949769_1 879212.DespoDRAFT_02643 2e-66 212.0 COG1227@1|root,COG1227@2|Bacteria,1RE45@1224|Proteobacteria,42RM1@68525|delta/epsilon subdivisions,2WNVB@28221|Deltaproteobacteria,2MJTY@213118|Desulfobacterales 28221|Deltaproteobacteria C DHHA2 - - 3.6.1.11 ko:K01514 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - DHH,DHHA2 k59_165382_1 644282.Deba_2537 2.84e-146 439.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42M86@68525|delta/epsilon subdivisions,2WIT1@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - HSDR_N,ResIII k59_720918_1 572544.Ilyop_0205 7.06e-135 395.0 COG0056@1|root,COG0056@2|Bacteria,378SQ@32066|Fusobacteria 32066|Fusobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_720918_2 572544.Ilyop_0204 4.66e-68 211.0 COG0712@1|root,COG0712@2|Bacteria,379A4@32066|Fusobacteria 32066|Fusobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_720918_3 572544.Ilyop_0203 3.54e-35 127.0 COG0711@1|root,COG0711@2|Bacteria,37ATG@32066|Fusobacteria 32066|Fusobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_720918_4 190304.FN0363 9.4e-42 138.0 COG0636@1|root,COG0636@2|Bacteria,37AJP@32066|Fusobacteria 32066|Fusobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_720918_5 572544.Ilyop_0201 2.5e-58 188.0 COG0356@1|root,COG0356@2|Bacteria,378C0@32066|Fusobacteria 32066|Fusobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_982282_1 335543.Sfum_1549 9.13e-109 347.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MR0B@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1015033_1 305900.GV64_19320 2.09e-75 232.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1XJ7K@135619|Oceanospirillales 135619|Oceanospirillales T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_917183_1 82654.Pse7367_1746 4.92e-08 54.7 COG1468@1|root,COG1468@2|Bacteria,1G00B@1117|Cyanobacteria,1H84S@1150|Oscillatoriales 1117|Cyanobacteria L TIGRFAM CRISPR-associated protein Cas4 - - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas4 k59_917183_2 1249627.D779_1651 4.75e-64 207.0 COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,1RNYK@1236|Gammaproteobacteria,1WWHK@135613|Chromatiales 135613|Chromatiales L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1,Cas_Cas4 k59_557679_1 1122225.AULQ01000007_gene2257 1.42e-74 236.0 COG0438@1|root,COG0438@2|Bacteria,4NE53@976|Bacteroidetes,1HX83@117743|Flavobacteriia 976|Bacteroidetes M glycosyl transferase - - - - - - - - - - - - Glycos_transf_1 k59_753500_1 411476.BACOVA_04920 2.04e-36 144.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,2G214@200643|Bacteroidia,4ATIU@815|Bacteroidaceae 976|Bacteroidetes G Putative binding domain, N-terminal - - - - - - - - - - - - BACON k59_753500_2 1168034.FH5T_00835 1.03e-25 103.0 COG4677@1|root,COG4677@2|Bacteria,4NEEI@976|Bacteroidetes,2FMFM@200643|Bacteroidia 976|Bacteroidetes G Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pec_lyase,Pectinesterase k59_1015037_1 827.JFJK01000001_gene830 3.23e-16 84.3 COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,42PK9@68525|delta/epsilon subdivisions,2YNXX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Oxygen tolerance - - - - - - - - - - - - BatD k59_197895_1 1415755.JQLV01000001_gene1345 1.36e-44 158.0 COG4984@1|root,COG4984@2|Bacteria,1RB7Y@1224|Proteobacteria,1S046@1236|Gammaproteobacteria,1XKME@135619|Oceanospirillales 135619|Oceanospirillales S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157 k59_66980_1 748247.AZKH_4047 3.94e-79 246.0 COG1108@1|root,COG1108@2|Bacteria,1PM37@1224|Proteobacteria,2VM6C@28216|Betaproteobacteria,2KY4A@206389|Rhodocyclales 206389|Rhodocyclales P ABC 3 transport family - - - ko:K02075 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ABC-3 k59_66980_2 1163617.SCD_n00316 9.66e-91 276.0 COG0803@1|root,COG0803@2|Bacteria,1PQEX@1224|Proteobacteria 1224|Proteobacteria P Periplasmic solute binding protein znuA - - ko:K02077 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ZnuA k59_132567_1 387093.SUN_1611 6.91e-72 225.0 COG3943@1|root,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,42NYC@68525|delta/epsilon subdivisions,2YN8N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Virulence protein RhuM family - - - - - - - - - - - - Virulence_RhuM k59_132568_1 1269813.ATUL01000031_gene1393 7.14e-08 58.9 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1WVWX@135613|Chromatiales 135613|Chromatiales CH TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 - - - ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R08768 RC00046 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_197898_1 765912.Thimo_2272 2.66e-14 69.7 2ECCI@1|root,336AU@2|Bacteria,1NG5X@1224|Proteobacteria,1SUHH@1236|Gammaproteobacteria,1X1UM@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_917185_2 572544.Ilyop_1841 4.95e-241 674.0 COG0215@1|root,COG0215@2|Bacteria,378N1@32066|Fusobacteria 32066|Fusobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_917185_3 1499683.CCFF01000014_gene4168 1.46e-12 65.9 COG1939@1|root,COG1939@2|Bacteria,1VA5V@1239|Firmicutes,24MR1@186801|Clostridia,36JIS@31979|Clostridiaceae 186801|Clostridia J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) mrnC - - ko:K11145 - - - - ko00000,ko01000,ko03009 - - - Ribonuclease_3 k59_949798_1 314271.RB2654_06719 8.43e-12 70.5 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2 k59_394068_1 709986.Deima_0264 1.57e-22 101.0 COG2217@1|root,COG2217@2|Bacteria,1WJ55@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P ATPase P-type (Transporting), HAD superfamily, subfamily IC pacS - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_492134_1 102107.XP_008244832.1 4.06e-62 192.0 2C63X@1|root,2S2ZC@2759|Eukaryota,37VFD@33090|Viridiplantae,3GJPI@35493|Streptophyta,4JW29@91835|fabids 35493|Streptophyta - - - - - - - - - - - - - - - k59_492134_2 29730.Gorai.001G162400.1 1.54e-38 136.0 COG1845@1|root,KOG4664@2759|Eukaryota,37QER@33090|Viridiplantae,3G8C5@35493|Streptophyta 35493|Streptophyta C cytochrome c oxidase subunit 3 cox3 - - ko:K02262 ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.11,3.D.4.7,3.D.4.8 - - COX3 k59_230676_1 1454004.AW11_01952 2.48e-13 67.4 COG0071@1|root,COG0071@2|Bacteria,1N0RH@1224|Proteobacteria,2VVUG@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - - - - - - - - - - HSP20 k59_230676_2 1168059.KB899087_gene2513 1.77e-34 132.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2U0IK@28211|Alphaproteobacteria,3F0G8@335928|Xanthobacteraceae 28211|Alphaproteobacteria O Found in ATP-dependent protease La (LON) MA20_45155 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_949801_1 1232410.KI421414_gene2846 1.24e-25 105.0 COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria,43T0K@69541|Desulfuromonadales 28221|Deltaproteobacteria S Domain of unknown function (DUF374) - - - ko:K09778 - - - - ko00000 - - - DUF374 k59_720950_1 1002340.AFCF01000028_gene3138 1.39e-74 234.0 COG2114@1|root,COG2114@2|Bacteria,1R75D@1224|Proteobacteria,2U4P3@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc,cNMP_binding k59_426580_1 990073.ATHU01000001_gene876 1.46e-44 160.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2YMQT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the peptidase S1C family htrA - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_753517_1 1217718.ALOU01000019_gene2692 9.25e-34 120.0 COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,2VTXS@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III nirC - - ko:K19344 - - - - ko00000 - - - Cytochrome_CBB3 k59_524833_6 709032.Sulku_1206 1.54e-06 53.1 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind,Laminin_G_3 k59_524833_9 153948.NAL212_0426 1e-06 58.5 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VNQ5@28216|Betaproteobacteria,373VM@32003|Nitrosomonadales 28216|Betaproteobacteria Q Haemolysin-type calcium-binding - - - - - - - - - - - - CAP,HemolysinCabind,Peptidase_M10,VCBS k59_917196_1 105559.Nwat_2653 5.97e-41 142.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1WWNN@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine - - 2.4.2.28,2.4.2.44 ko:K00772,ko:K19696 ko00270,ko01100,map00270,map01100 M00034 R01402,R09668 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_917196_2 768066.HELO_2708 2.84e-17 78.2 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XJQK@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_786210_1 1123400.KB904772_gene3330 1.35e-110 327.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,460VQ@72273|Thiotrichales 72273|Thiotrichales S PFAM Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - - - - - - - - - - LigB k59_786210_2 1408439.JHXW01000001_gene1886 3.85e-93 278.0 COG1335@1|root,COG1335@2|Bacteria,378G9@32066|Fusobacteria 32066|Fusobacteria Q Isochorismatase family - - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase k59_786210_3 572544.Ilyop_1778 6.08e-139 397.0 COG0052@1|root,COG0052@2|Bacteria,3795U@32066|Fusobacteria 32066|Fusobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_786210_4 556263.FSEG_01659 9.12e-142 408.0 COG0264@1|root,COG0264@2|Bacteria,378TR@32066|Fusobacteria 32066|Fusobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_786210_5 1319815.HMPREF0202_02715 8.31e-139 396.0 COG0528@1|root,COG0528@2|Bacteria,3786C@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_786210_6 572544.Ilyop_1775 2.14e-95 281.0 COG0233@1|root,COG0233@2|Bacteria,378W9@32066|Fusobacteria 32066|Fusobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_786210_7 469616.FMAG_02378 2.31e-107 315.0 COG0020@1|root,COG0020@2|Bacteria,37853@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_786210_8 572544.Ilyop_1773 1.25e-80 251.0 COG0575@1|root,COG0575@2|Bacteria,37A25@32066|Fusobacteria 32066|Fusobacteria I Cytidylyltransferase family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_786210_9 572544.Ilyop_1772 3.93e-183 520.0 COG0743@1|root,COG0743@2|Bacteria,378W2@32066|Fusobacteria 32066|Fusobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_786210_10 469618.FVAG_02813 2.35e-94 282.0 COG0125@1|root,COG0125@2|Bacteria,379MW@32066|Fusobacteria 32066|Fusobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_786210_12 572544.Ilyop_1769 1.65e-127 375.0 COG0750@1|root,COG0750@2|Bacteria,378E4@32066|Fusobacteria 32066|Fusobacteria M RIP metalloprotease RseP rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_786210_13 572544.Ilyop_1768 7.19e-138 402.0 COG0161@1|root,COG0161@2|Bacteria,3791N@32066|Fusobacteria 32066|Fusobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_688293_1 1163617.SCD_n01919 4.95e-48 160.0 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2VSDI@28216|Betaproteobacteria 28216|Betaproteobacteria S protein SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_688293_2 396588.Tgr7_1952 1.04e-08 56.6 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1WYZ4@135613|Chromatiales 135613|Chromatiales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_884284_1 1122604.JONR01000068_gene4230 6.17e-71 218.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1X514@135614|Xanthomonadales 135614|Xanthomonadales S carbonic - - - - - - - - - - - - Hexapep k59_818960_1 1304885.AUEY01000022_gene3407 5.16e-91 278.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42PMQ@68525|delta/epsilon subdivisions,2WKB8@28221|Deltaproteobacteria,2MIF9@213118|Desulfobacterales 28221|Deltaproteobacteria K Transcriptional regulator, LysR - - - - - - - - - - - - HTH_1,LysR_substrate k59_1739_2 572480.Arnit_0032 1.12e-33 116.0 COG5554@1|root,COG5554@2|Bacteria,1Q3JU@1224|Proteobacteria,42XF5@68525|delta/epsilon subdivisions,2YQVJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q nitrogen fixation protein FixT - - - ko:K02593 - - - - ko00000 - - - NifT k59_623476_1 1234664.AMRO01000004_gene2585 2.61e-13 72.4 COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4HCSN@91061|Bacilli,1WFP9@129337|Geobacillus 91061|Bacilli G Periplasmic binding protein domain - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_329468_1 1121904.ARBP01000031_gene555 3.05e-61 214.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,47NVQ@768503|Cytophagia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_367458_1 880071.Fleli_3680 5.81e-16 84.7 COG0771@1|root,COG0771@2|Bacteria,4NEFF@976|Bacteroidetes,47KTX@768503|Cytophagia 976|Bacteroidetes M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_595849_1 1245471.PCA10_38260 7.61e-57 195.0 COG2267@1|root,COG2267@2|Bacteria,1MX2H@1224|Proteobacteria,1RRSX@1236|Gammaproteobacteria,1YEQQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M serine threonine protein kinase - - - - - - - - - - - - - k59_531165_1 1380387.JADM01000023_gene1842 8.67e-129 393.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XH2S@135619|Oceanospirillales 135619|Oceanospirillales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_824785_1 591001.Acfer_1986 1.41e-77 247.0 COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,4H93U@909932|Negativicutes 909932|Negativicutes S BFD-like [2Fe-2S] binding domain - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD k59_726369_1 1038859.AXAU01000005_gene5082 5.86e-14 70.9 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria,3JV28@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C cytochrome c oxidase subunit III ctaE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_726369_2 1121033.AUCF01000027_gene2747 5.82e-72 223.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,2JSCM@204441|Rhodospirillales 204441|Rhodospirillales O Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I ctaG - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_431813_1 1121403.AUCV01000028_gene2420 1.09e-37 135.0 COG3500@1|root,COG3500@2|Bacteria,1Q2U5@1224|Proteobacteria,42UA7@68525|delta/epsilon subdivisions,2WQM0@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Late control gene D protein - - - - - - - - - - - - Phage_GPD k59_431813_2 1121403.AUCV01000028_gene2421 2.85e-88 263.0 COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,42Q1X@68525|delta/epsilon subdivisions,2WM75@28221|Deltaproteobacteria,2MNWA@213118|Desulfobacterales 28221|Deltaproteobacteria S Baseplate assembly protein - - - - - - - - - - - - - k59_498357_1 709032.Sulku_2058 1.15e-48 159.0 COG1143@1|root,COG1143@2|Bacteria,1RK71@1224|Proteobacteria,42Y1X@68525|delta/epsilon subdivisions 1224|Proteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein echF - 1.6.5.3 ko:K00338,ko:K14091 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - ETF_QO,Fer4,Fer4_7 k59_498357_2 1537917.JU82_08435 1.35e-29 117.0 COG1251@1|root,COG1740@1|root,COG1251@2|Bacteria,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42PSD@68525|delta/epsilon subdivisions,2YNBA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C hydrogenase (NiFe) small subunit HydA - - 1.12.5.1 ko:K05927 - - - - ko00000,ko01000 - - - Fer2_BFD,NiFe_hyd_SSU_C,Oxidored_q6,Pyr_redox_2 k59_39143_1 1168034.FH5T_14045 1.42e-16 76.3 293VW@1|root,2ZRB2@2|Bacteria,4NMK7@976|Bacteroidetes,2FUEE@200643|Bacteroidia 976|Bacteroidetes S Gliding motility-associated lipoprotein GldD gldD - - - - - - - - - - - - k59_39143_2 1168034.FH5T_14050 5.59e-134 391.0 COG1253@1|root,COG1253@2|Bacteria,4NDZ7@976|Bacteroidetes,2FMEZ@200643|Bacteroidia 976|Bacteroidetes S gliding motility-associated protein GldE gldE - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_531180_1 1286106.MPL1_05679 1.27e-81 266.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,45ZWT@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_563699_1 1123393.KB891316_gene1127 2.64e-64 202.0 COG1416@1|root,COG1416@2|Bacteria,1RHW0@1224|Proteobacteria,2VWXN@28216|Betaproteobacteria,1KSFB@119069|Hydrogenophilales 119069|Hydrogenophilales S DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_335206_1 869213.JCM21142_104169 5e-214 612.0 COG3256@1|root,COG3256@2|Bacteria,4NG9H@976|Bacteroidetes,47K63@768503|Cytophagia 976|Bacteroidetes P Cytochrome C and Quinol oxidase polypeptide I - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_955049_1 748280.NH8B_3475 1e-47 173.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KQ2R@206351|Neisseriales 206351|Neisseriales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_531185_1 269799.Gmet_2573 3.86e-70 227.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,43T9G@69541|Desulfuromonadales 28221|Deltaproteobacteria L helicase superfamily c-terminal domain rhlE-2 - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_106336_1 76869.PputGB1_4738 1.38e-77 256.0 COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,1RM7Z@1236|Gammaproteobacteria,1YXWK@136845|Pseudomonas putida group 1236|Gammaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein lldE - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8 k59_988308_1 562743.JH976435_gene2714 3.41e-32 127.0 28I94@1|root,2Z8BU@2|Bacteria,1UE59@1239|Firmicutes,4HT4J@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_988308_2 218284.CCDN010000005_gene3206 6.31e-19 89.0 COG4565@1|root,COG4565@2|Bacteria,1V3PK@1239|Firmicutes,4HGXB@91061|Bacilli,1ZFRB@1386|Bacillus 91061|Bacilli T COG4565 Response regulator of citrate malate metabolism dcuR - - ko:K02475,ko:K11615 ko02020,map02020 M00490 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_11,Response_reg k59_465714_2 395493.BegalDRAFT_3002 2.1e-61 199.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,460E1@72273|Thiotrichales 72273|Thiotrichales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_39155_1 290397.Adeh_1979 1.33e-90 270.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42QN7@68525|delta/epsilon subdivisions,2WP27@28221|Deltaproteobacteria,2YVXG@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_923402_2 765912.Thimo_0506 1.17e-10 61.6 2DWCI@1|root,33ZMQ@2|Bacteria,1NXC9@1224|Proteobacteria,1SQEH@1236|Gammaproteobacteria,1X12A@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_531190_1 713586.KB900536_gene1923 1.33e-13 71.2 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_531190_2 1249627.D779_0944 1.26e-64 199.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales 135613|Chromatiales J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_628933_2 927658.AJUM01000022_gene1003 3.35e-08 63.5 COG1361@1|root,COG2304@1|root,COG5184@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG5184@2|Bacteria,4NMB8@976|Bacteroidetes,2G13I@200643|Bacteroidia,3XJY5@558415|Marinilabiliaceae 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,DUF11 k59_268334_1 1453501.JELR01000002_gene230 8.63e-08 53.9 COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,1S0BA@1236|Gammaproteobacteria,464QN@72275|Alteromonadaceae 1236|Gammaproteobacteria M Glycosyl transferase 4-like domain - - 2.4.1.56 ko:K03280 ko00540,ko01100,map00540,map01100 M00080 R01996 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4,GT9 - Glyco_transf_4,Glycos_transf_1 k59_268334_2 1120950.KB892731_gene3798 1.38e-13 75.5 COG1216@1|root,COG1216@2|Bacteria,2I5Z7@201174|Actinobacteria,4DR9J@85009|Propionibacteriales 201174|Actinobacteria M Glycosyl transferase family 2 - - 2.4.1.289 ko:K16870 - - - - ko00000,ko01000,ko01003 - - - Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2 k59_465722_1 545264.KB898752_gene2416 8.89e-60 192.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1WX46@135613|Chromatiales 135613|Chromatiales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_465722_2 882378.RBRH_02217 0.000368 42.0 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,1K9EN@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the UPF0250 family ybeD - - ko:K09158 - - - - ko00000 - - - DUF493 k59_889604_1 765914.ThisiDRAFT_1157 9.5e-60 208.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_758962_1 642492.Clole_4016 1.98e-32 116.0 COG1051@1|root,COG1051@2|Bacteria 2|Bacteria F GDP-mannose mannosyl hydrolase activity - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_758962_2 1047013.AQSP01000119_gene1318 3.79e-58 188.0 COG4843@1|root,COG4843@2|Bacteria,2NPKB@2323|unclassified Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 k59_139067_1 267608.RSp0530 2.56e-36 140.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,1K16F@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_563723_1 1168034.FH5T_05880 3.24e-32 122.0 COG0017@1|root,COG0017@2|Bacteria,4NDY4@976|Bacteroidetes,2FKYI@200643|Bacteroidia 976|Bacteroidetes J Asparaginyl-tRNA synthetase asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_563723_2 1408473.JHXO01000010_gene3638 0.000243 40.8 2EBCA@1|root,335D0@2|Bacteria,4NUYY@976|Bacteroidetes 976|Bacteroidetes S Coenzyme PQQ synthesis protein D (PqqD) - - - - - - - - - - - - PqqD k59_367511_1 387093.SUN_0200 1.49e-78 245.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2YMD8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_595894_1 1335757.SPICUR_01485 1.21e-43 162.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_531213_1 1304275.C41B8_15867 2.19e-46 164.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_595895_1 1267533.KB906733_gene2828 5.06e-27 114.0 COG5361@1|root,COG5361@2|Bacteria 2|Bacteria P Conserved Protein - - - - - - - - - - - - DUF1214,DUF1254 k59_73266_1 1286106.MPL1_03880 7.49e-106 323.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,45ZSX@72273|Thiotrichales 72273|Thiotrichales NU Type II IV secretion system protein pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_73266_2 1121015.N789_11290 3.67e-14 73.2 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1X49V@135614|Xanthomonadales 135614|Xanthomonadales U Type II secretory pathway pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_628964_1 2340.JV46_22100 1.84e-15 77.8 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1J665@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria GM COG0451 Nucleoside-diphosphate-sugar epimerases - - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind k59_628964_2 748658.KB907312_gene1808 2.46e-20 88.6 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1WVYQ@135613|Chromatiales 135613|Chromatiales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_465739_1 1173024.KI912148_gene2629 2.99e-31 126.0 COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1G46J@1117|Cyanobacteria,1JH02@1189|Stigonemataceae 1117|Cyanobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c,HisKA,PAS_9 k59_237182_2 768671.ThimaDRAFT_0291 5.16e-160 457.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1WXFU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_172219_1 1122176.KB903546_gene1017 1.88e-17 77.0 COG0607@1|root,COG0607@2|Bacteria,4NVM6@976|Bacteroidetes,1IZ3G@117747|Sphingobacteriia 976|Bacteroidetes P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_172219_2 994479.GL877878_gene1142 4.7e-12 67.8 COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4E1PW@85010|Pseudonocardiales 201174|Actinobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP GO:0006950,GO:0008150,GO:0050896,GO:0051409 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_139899_1 290317.Cpha266_2328 8.71e-69 233.0 COG1924@1|root,COG1924@2|Bacteria 2|Bacteria I 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_301824_1 96561.Dole_2009 2.74e-16 77.0 COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,42NM4@68525|delta/epsilon subdivisions,2WJ8H@28221|Deltaproteobacteria,2MJ16@213118|Desulfobacterales 28221|Deltaproteobacteria S alpha/beta hydrolase fold - - 3.8.1.5 ko:K01563,ko:K22318 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_301824_2 933262.AXAM01000054_gene2673 7.56e-55 181.0 COG0332@1|root,COG0332@2|Bacteria,1P9I2@1224|Proteobacteria,42PE7@68525|delta/epsilon subdivisions,2WJZZ@28221|Deltaproteobacteria,2MHMU@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III fabH-3 - - ko:K22317 - - - - ko00000 - - - ACP_syn_III,ACP_syn_III_C,Thiolase_N k59_924211_1 1168034.FH5T_09465 2.96e-31 116.0 COG0284@1|root,COG0284@2|Bacteria,4NE12@976|Bacteroidetes,2FPJM@200643|Bacteroidia 976|Bacteroidetes F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_924211_2 1168034.FH5T_09470 1.36e-69 223.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,2FQ0Q@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_727147_1 999550.KI421507_gene2650 0.000446 48.1 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR1S@28211|Alphaproteobacteria 28211|Alphaproteobacteria T signal transduction histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 k59_989168_1 745411.B3C1_06598 1.74e-20 94.7 COG2813@1|root,COG2813@2|Bacteria,1MXE9@1224|Proteobacteria,1RQCH@1236|Gammaproteobacteria,1J64R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle rsmC GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052914,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.172 ko:K00564 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - MTS,MTS_N k59_989168_2 925775.XVE_3131 2.56e-40 146.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1X3IZ@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_989169_1 762211.BSTEL_1031 2.14e-14 79.7 COG0463@1|root,COG0463@2|Bacteria,2I2GT@201174|Actinobacteria,4CZ0W@85004|Bifidobacteriales 201174|Actinobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_924220_1 1380394.JADL01000001_gene2696 0.000681 43.5 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2TV39@28211|Alphaproteobacteria,2JR6C@204441|Rhodospirillales 204441|Rhodospirillales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_727154_1 1168289.AJKI01000067_gene1499 2.7e-130 380.0 COG4948@1|root,COG4948@2|Bacteria,4NG8N@976|Bacteroidetes,2FNCM@200643|Bacteroidia,3XJ2I@558415|Marinilabiliaceae 976|Bacteroidetes M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain ykfB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20,5.1.1.3 ko:K01776,ko:K19802 ko00471,ko01100,map00471,map01100 - R00260,R10938 RC00302,RC03309 ko00000,ko00001,ko01000,ko01011 - - - MR_MLE_C,MR_MLE_N k59_432643_1 743718.Isova_2719 1.93e-84 262.0 COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4F3JS@85017|Promicromonosporaceae 201174|Actinobacteria E ACT domain ask GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_564512_1 1120999.JONM01000005_gene3882 2.93e-10 69.7 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria,2KU0C@206351|Neisseriales 28216|Betaproteobacteria M RHS Repeat - - - - - - - - - - - - RHS_repeat k59_791470_1 1408473.JHXO01000010_gene3647 1.63e-12 67.0 2BUJT@1|root,32VAI@2|Bacteria,4NSUJ@976|Bacteroidetes,2G2HM@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_791470_2 1168034.FH5T_09965 2.09e-26 103.0 2AFPW@1|root,315RN@2|Bacteria,4NFY9@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_629839_1 572544.Ilyop_0522 2.68e-116 345.0 COG1570@1|root,COG1570@2|Bacteria,3798J@32066|Fusobacteria 32066|Fusobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_890464_1 709032.Sulku_0681 3.27e-150 434.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2YMEB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_466429_1 387093.SUN_0477 9.7e-135 391.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2YMEX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0183 SHMT k59_39900_1 1283300.ATXB01000001_gene2446 1.14e-99 304.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1XDIP@135618|Methylococcales 135618|Methylococcales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_204708_1 438753.AZC_0236 7.93e-126 366.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,3EYA2@335928|Xanthobacteraceae 28211|Alphaproteobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain gyaR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_629847_1 1537917.JU82_06955 2.57e-34 127.0 COG0176@1|root,COG0176@2|Bacteria,1N9G3@1224|Proteobacteria,42MCK@68525|delta/epsilon subdivisions,2YMRY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_629847_2 709032.Sulku_1926 2.31e-114 338.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2YMC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU twitching motility protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_39905_1 187272.Mlg_1866 1.07e-88 271.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1WWET@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class I and II - - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_466439_1 323850.Shew_0983 1.19e-67 221.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,2QAS1@267890|Shewanellaceae 1236|Gammaproteobacteria Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_432666_1 749222.Nitsa_1339 8.71e-114 344.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2YMYX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g,tRNA_bind k59_532108_1 1168034.FH5T_18895 6.4e-134 394.0 COG0457@1|root,COG0457@2|Bacteria,4NWTK@976|Bacteroidetes 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19,TPR_8 k59_532108_2 1168034.FH5T_11285 1.78e-21 89.7 COG0810@1|root,COG0810@2|Bacteria,4NMG7@976|Bacteroidetes,2FPKW@200643|Bacteroidia 976|Bacteroidetes M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_74192_1 1249480.B649_05395 6.65e-113 342.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,43AEI@68525|delta/epsilon subdivisions,2YT3E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_336149_2 1537917.JU82_08305 4.34e-95 290.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2YNM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T ATPase related to phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_237232_1 1134474.O59_001109 3.87e-36 139.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1FH4H@10|Cellvibrio 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_596840_1 933262.AXAM01000005_gene2521 7.55e-07 50.4 COG2882@1|root,COG2882@2|Bacteria,1NNS8@1224|Proteobacteria,42XQJ@68525|delta/epsilon subdivisions,2WSXU@28221|Deltaproteobacteria 28221|Deltaproteobacteria N Flagellar FliJ protein fliJ - - ko:K02413 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliJ k59_269077_1 1460635.JCM19038_1485 8.94e-19 90.1 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,4H9TI@91061|Bacilli 91061|Bacilli I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_466444_1 927658.AJUM01000037_gene2022 2.44e-09 58.9 COG0673@1|root,COG0673@2|Bacteria,4NE07@976|Bacteroidetes,2FNUN@200643|Bacteroidia,3XJP4@558415|Marinilabiliaceae 976|Bacteroidetes S Oxidoreductase family, C-terminal alpha/beta domain gfo_1 - 1.1.1.384 ko:K13327 ko00523,ko01130,map00523,map01130 M00801,M00802 R05526 RC00897 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like,GFO_IDH_MocA,GFO_IDH_MocA_C k59_466444_2 1461579.CCNK01000020_gene491 2.85e-22 91.3 COG2731@1|root,COG2731@2|Bacteria,1RBKM@1224|Proteobacteria,1S4YJ@1236|Gammaproteobacteria,1Y8UF@135625|Pasteurellales 135625|Pasteurellales G EbgC protein Z012_01470 - - - - - - - - - - - DUF386 k59_924253_1 572544.Ilyop_1425 4.68e-75 254.0 COG0658@1|root,COG0658@2|Bacteria,378SE@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence k59_924253_2 1321779.HMPREF1984_01757 1.18e-65 211.0 COG1994@1|root,COG1994@2|Bacteria,379C9@32066|Fusobacteria 32066|Fusobacteria S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_700913_2 1123248.KB893315_gene2947 2.36e-22 95.9 COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,1IPWK@117747|Sphingobacteriia 976|Bacteroidetes G Glycoside hydrolase, family 2 - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_106,Glyco_hydro_2_N k59_995627_1 1172190.M947_02320 1.97e-38 133.0 COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SJM@68525|delta/epsilon subdivisions,2YPJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_995627_2 387093.SUN_1876 2.06e-57 189.0 COG2404@1|root,COG2404@2|Bacteria,1NHB1@1224|Proteobacteria,42NB0@68525|delta/epsilon subdivisions,2YMQ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S phosphohydrolase (DHH superfamily) - - - ko:K07097 - - - - ko00000 - - - DHHA1 k59_636147_1 1165841.SULAR_01465 1.42e-135 398.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2YN1U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_438597_1 1172190.M947_02205 2.05e-119 354.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2YMM2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_636150_1 1283300.ATXB01000001_gene1261 4.26e-12 66.2 COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,1T1Q4@1236|Gammaproteobacteria,1XE42@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA k59_636150_2 391615.ABSJ01000033_gene708 7.57e-63 205.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains pilR - - ko:K02481,ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_863742_1 768671.ThimaDRAFT_3762 1.63e-99 306.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1WW0E@135613|Chromatiales 135613|Chromatiales G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_112635_1 1537917.JU82_04585 1.46e-75 237.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2YMGX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_930489_1 485918.Cpin_5597 2.35e-06 50.8 COG2972@1|root,COG2972@2|Bacteria,4NHM5@976|Bacteroidetes,1IRRM@117747|Sphingobacteriia 976|Bacteroidetes T PFAM histidine kinase - - - - - - - - - - - - HATPase_c_5,His_kinase k59_930489_2 1250005.PHEL85_1686 3.85e-82 250.0 COG3279@1|root,COG3279@2|Bacteria,4NI3K@976|Bacteroidetes,1HZ0N@117743|Flavobacteriia,3VWFD@52959|Polaribacter 976|Bacteroidetes K Two-component system response regulator - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_9310_1 765911.Thivi_1727 1.09e-128 378.0 COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,1RQGG@1236|Gammaproteobacteria,1WXV8@135613|Chromatiales 135613|Chromatiales P Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto k59_211484_1 414684.RC1_1459 1.35e-18 84.3 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JPVQ@204441|Rhodospirillales 204441|Rhodospirillales E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - - ko:K11076 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - ABC_tran,TOBE_2 k59_211484_2 945543.VIBR0546_07322 2.74e-29 115.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,1XW4V@135623|Vibrionales 135623|Vibrionales E Required for the activity of the bacterial periplasmic transport system of putrescine - - - ko:K11073 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - SBP_bac_8 k59_9313_1 485915.Dret_0562 3.25e-35 135.0 COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,42PU8@68525|delta/epsilon subdivisions,2WJ2M@28221|Deltaproteobacteria,2M9Z4@213115|Desulfovibrionales 28221|Deltaproteobacteria MU type I secretion outer membrane protein, TolC - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP k59_930498_2 1507.HMPREF0262_00678 6.13e-34 126.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36EAA@31979|Clostridiaceae 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 k59_732564_1 1124983.PFLCHA0_c05950 1.73e-19 89.7 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1YNXE@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_732564_2 1121937.AUHJ01000004_gene1132 1.07e-33 129.0 COG1020@1|root,COG1020@2|Bacteria,1R76E@1224|Proteobacteria,1SZT4@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_79727_1 387093.SUN_1004 1.91e-55 193.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2YRC9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_795532_1 888727.HMPREF9092_1152 4.36e-43 160.0 COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,3WCJ6@538999|Clostridiales incertae sedis 186801|Clostridia M Domain present in PSD-95, Dlg, and ZO-1/2. rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_863757_1 1120970.AUBZ01000030_gene3077 4.88e-31 121.0 COG1609@1|root,COG1609@2|Bacteria,1MU1G@1224|Proteobacteria,1RMSP@1236|Gammaproteobacteria,465QA@72275|Alteromonadaceae 1236|Gammaproteobacteria K transcriptional - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_962405_1 1178825.ALIH01000002_gene883 3.28e-16 87.4 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,1HWKQ@117743|Flavobacteriia 976|Bacteroidetes S PFAM Family of - - - - - - - - - - - - TamB k59_732567_1 1123073.KB899241_gene2672 1.68e-73 233.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1X3IR@135614|Xanthomonadales 135614|Xanthomonadales C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - CBS,Iso_dh k59_636175_1 1249627.D779_2341 4.71e-75 241.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales 135613|Chromatiales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_406469_1 522306.CAP2UW1_0311 1.86e-17 87.4 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,1KPNU@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_766118_1 1121352.JHZP01000009_gene1809 8.99e-18 86.3 COG3210@1|root,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,2VI40@28216|Betaproteobacteria,2KQQA@206351|Neisseriales 206351|Neisseriales U Large exoproteins involved in heme utilization or adhesion - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act k59_506407_1 1168034.FH5T_08280 9.03e-35 127.0 COG1180@1|root,COG1180@2|Bacteria,4NIUZ@976|Bacteroidetes,2FP2R@200643|Bacteroidia 976|Bacteroidetes C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4,Fer4_12,Radical_SAM k59_146495_1 1232437.KL662038_gene2296 2.08e-68 223.0 COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43DC7@68525|delta/epsilon subdivisions,2X8I7@28221|Deltaproteobacteria,2MPQ6@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg k59_506414_1 929562.Emtol_0574 4.37e-78 249.0 COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,47MBT@768503|Cytophagia 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_274451_1 388399.SSE37_16848 5.19e-14 67.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_274451_2 713587.THITH_04050 2.31e-39 145.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1WW79@135613|Chromatiales 135613|Chromatiales H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_342823_1 1453501.JELR01000001_gene2977 1.5e-12 70.5 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,466B8@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA polymerase III, delta subunit holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_342823_2 396588.Tgr7_2275 5.48e-71 222.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales 135613|Chromatiales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_243086_1 469616.FMAG_02083 2.92e-07 59.3 COG0642@1|root,COG5000@1|root,COG0642@2|Bacteria,COG5000@2|Bacteria,3784S@32066|Fusobacteria 32066|Fusobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HAMP,HATPase_c k59_243086_2 1321774.HMPREF9108_00010 0.0 892.0 COG2183@1|root,COG2183@2|Bacteria,379B1@32066|Fusobacteria 32066|Fusobacteria K Psort location Cytoplasmic, score - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_243086_3 273068.TTE0520 2.72e-36 129.0 COG1827@1|root,COG1827@2|Bacteria,1V6EY@1239|Firmicutes,24JF2@186801|Clostridia,42G2G@68295|Thermoanaerobacterales 186801|Clostridia C PFAM 3H domain niaR - - ko:K07105 - - - - ko00000 - - - 3H,HTH_11 k59_669347_1 177437.HRM2_30110 1.73e-42 157.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2MJ19@213118|Desulfobacterales 28221|Deltaproteobacteria NU Bacterial type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_506419_1 391587.KAOT1_02029 2.78e-31 124.0 COG3547@1|root,COG3547@2|Bacteria,4NKDC@976|Bacteroidetes,1HXB1@117743|Flavobacteriia 976|Bacteroidetes L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_146503_1 1239962.C943_03721 6.42e-50 176.0 COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes,47NUP@768503|Cytophagia 976|Bacteroidetes V Domain of unknown function (DUF3471) - - - - - - - - - - - - Beta-lactamase,DUF3471 k59_146503_2 1168034.FH5T_01410 1.4e-20 84.3 2EFPT@1|root,339FT@2|Bacteria,4NV1V@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_930535_1 1168034.FH5T_15240 2.88e-151 447.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE4A@976|Bacteroidetes,2FX71@200643|Bacteroidia 976|Bacteroidetes C Dehydrogenase E1 component pdhB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_243096_1 1125863.JAFN01000001_gene633 9.39e-77 245.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42P15@68525|delta/epsilon subdivisions,2WK8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_7,rve k59_438651_1 944547.ABLL_2828 3.97e-96 287.0 COG3907@1|root,COG3907@2|Bacteria,1MY7B@1224|Proteobacteria,42RAC@68525|delta/epsilon subdivisions,2YRS3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PAP2 superfamily - - - - - - - - - - - - PAP2 k59_406501_1 1449347.JQLN01000005_gene5579 2.27e-06 51.2 COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria,2M052@2063|Kitasatospora 201174|Actinobacteria E Membrane dipeptidase (Peptidase family M19) Dpep - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_603731_1 1121033.AUCF01000016_gene5419 2.88e-104 311.0 COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2JPCP@204441|Rhodospirillales 204441|Rhodospirillales Q homogentisate 1,2-dioxygenase - - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_1027217_1 1168034.FH5T_09320 5.56e-217 611.0 COG1649@1|root,COG1649@2|Bacteria,4NFKQ@976|Bacteroidetes,2FMPU@200643|Bacteroidia 976|Bacteroidetes S lipoprotein YddW precursor - - - - - - - - - - - - GHL10 k59_930544_1 1249627.D779_0403 1.1e-143 410.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_930544_2 1230338.MOMA_05205 2.69e-31 120.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,3NK1I@468|Moraxellaceae 1236|Gammaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_570437_1 1121957.ATVL01000006_gene2731 6.24e-31 121.0 COG3137@1|root,COG3137@2|Bacteria,4NGB2@976|Bacteroidetes,47Q2F@768503|Cytophagia 976|Bacteroidetes M Protein of unknown function (DUF3078) - - - - - - - - - - - - DUF3078 k59_112703_2 335543.Sfum_2845 3.54e-60 194.0 COG1073@1|root,COG1073@2|Bacteria,1RBV1@1224|Proteobacteria,42M9M@68525|delta/epsilon subdivisions,2WM64@28221|Deltaproteobacteria,2MQDT@213462|Syntrophobacterales 28221|Deltaproteobacteria S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_766153_1 1279019.ARQK01000059_gene912 1.31e-18 85.9 COG4861@1|root,COG4861@2|Bacteria,1RFGZ@1224|Proteobacteria,1S42X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Transcriptional regulator, AbiEi antitoxin, Type IV TA system - - - - - - - - - - - - AbiEi_2 k59_766153_2 667632.KB890180_gene746 7.1e-13 69.3 COG4849@1|root,COG4849@2|Bacteria,1N4EJ@1224|Proteobacteria,2W30C@28216|Betaproteobacteria,1K2Y3@119060|Burkholderiaceae 28216|Betaproteobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_438662_1 1487953.JMKF01000070_gene3344 1.71e-63 205.0 COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1H8SW@1150|Oscillatoriales 1117|Cyanobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_570439_1 697282.Mettu_0405 5.66e-14 70.9 COG3459@1|root,COG3459@2|Bacteria,1R1HB@1224|Proteobacteria,1T531@1236|Gammaproteobacteria,1XG0G@135618|Methylococcales 135618|Methylococcales G Glycosyltransferase 36 associated - - - - - - - - - - - - - k59_570439_2 697282.Mettu_3478 5.61e-15 75.9 COG5520@1|root,COG5520@2|Bacteria,1N9T9@1224|Proteobacteria,1RP92@1236|Gammaproteobacteria,1XG0W@135618|Methylococcales 135618|Methylococcales M Belongs to the glycosyl hydrolase 30 family - - - - - - - - - - - - Glyco_hydro_30,Glyco_hydro_30C k59_732611_1 526218.Sterm_3385 4.38e-92 283.0 COG3775@1|root,COG3775@2|Bacteria,378FJ@32066|Fusobacteria 32066|Fusobacteria G PTS system Galactitol-specific IIC component - - - ko:K02775 ko00052,ko01100,ko02060,map00052,map01100,map02060 M00279 R05570 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.5.1 - - EIIC-GAT k59_211536_1 243231.GSU0975 1.04e-106 330.0 COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,42QD3@68525|delta/epsilon subdivisions,2WM12@28221|Deltaproteobacteria,43W16@69541|Desulfuromonadales 28221|Deltaproteobacteria L Phage tail sheath C-terminal domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_406510_1 1034769.KB910518_gene4871 5.08e-12 71.6 COG3039@1|root,COG3039@2|Bacteria,1TPFS@1239|Firmicutes,4H9V9@91061|Bacilli,26VAA@186822|Paenibacillaceae 91061|Bacilli L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_211539_1 880072.Desac_0487 3.25e-57 181.0 2DWSR@1|root,341Q6@2|Bacteria,1Q538@1224|Proteobacteria,430G3@68525|delta/epsilon subdivisions,2WVK2@28221|Deltaproteobacteria,2MRYW@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_243124_2 187272.Mlg_2443 8.54e-17 75.9 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales 135613|Chromatiales K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_112721_1 485913.Krac_6795 2.46e-44 153.0 COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi 200795|Chloroflexi C PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_307994_1 1168034.FH5T_14435 9.88e-23 95.1 COG2207@1|root,COG2207@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - AraC_binding,BLUF,HTH_18,Methyltransf_23,TPR_8 k59_9372_1 1434325.AZQN01000008_gene3032 0.000169 43.1 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,47KYY@768503|Cytophagia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_9372_2 1120968.AUBX01000010_gene1359 4.21e-35 134.0 COG0702@1|root,COG0702@2|Bacteria,4NEDB@976|Bacteroidetes,47KQ4@768503|Cytophagia 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_438685_1 1123247.AUIJ01000001_gene1635 2.09e-35 133.0 COG2374@1|root,COG2374@2|Bacteria,1NTH6@1224|Proteobacteria,2TVN3@28211|Alphaproteobacteria 28211|Alphaproteobacteria L endonuclease - - - - - - - - - - - - Exo_endo_phos k59_45420_2 406327.Mevan_0145 5.26e-48 162.0 COG3369@1|root,arCOG03174@2157|Archaea,2XX0Q@28890|Euryarchaeota 28890|Euryarchaeota S SMART zinc finger, CDGSH-type domain protein - - - - - - - - - - - - Fer4_19,zf-CDGSH k59_636247_2 1120999.JONM01000004_gene3473 4.66e-45 150.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VJMC@28216|Betaproteobacteria,2KPNQ@206351|Neisseriales 28216|Betaproteobacteria S Belongs to the WrbA family - - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_506468_1 1168034.FH5T_10310 1.24e-48 174.0 COG1413@1|root,COG1413@2|Bacteria,4NEZ7@976|Bacteroidetes,2FPRF@200643|Bacteroidia 976|Bacteroidetes C Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080,HEAT_2 k59_506468_2 1168034.FH5T_10315 1.72e-90 275.0 COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,2FPMK@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_996475_1 768671.ThimaDRAFT_0763 7.69e-88 264.0 COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria 1224|Proteobacteria C NADH ubiquinone oxidoreductase hoxU - 1.12.1.2 ko:K18006 - - - - ko00000,ko01000 - - - Fer2_4,Fer4_15,NADH-G_4Fe-4S_3 k59_472476_1 83406.HDN1F_22480 3.11e-81 259.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1J5AY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0608 Single-stranded DNA-specific exonuclease recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_507224_1 1335757.SPICUR_01585 5.92e-158 456.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales 135613|Chromatiales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_733334_1 523791.Kkor_2206 2.25e-36 125.0 COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,1S8Z1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L endonuclease containing a URI domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_179901_1 1107311.Q767_09940 2.25e-09 65.1 COG1357@1|root,COG3291@1|root,COG1357@2|Bacteria,COG3291@2|Bacteria,4PI2H@976|Bacteroidetes,1IA3E@117743|Flavobacteriia,2NXN5@237|Flavobacterium 976|Bacteroidetes DZ Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_375004_1 1168034.FH5T_11190 2.84e-87 262.0 COG2013@1|root,COG2013@2|Bacteria,4NFNA@976|Bacteroidetes,2FWBE@200643|Bacteroidia 976|Bacteroidetes S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k59_343673_2 349521.HCH_00528 7.8e-07 51.6 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1XHFY@135619|Oceanospirillales 135619|Oceanospirillales S Deacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_444040_1 933262.AXAM01000042_gene1832 4.54e-79 247.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2MIB1@213118|Desulfobacterales 28221|Deltaproteobacteria S VWA containing CoxE family protein - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_837008_1 1168034.FH5T_07465 1.43e-62 212.0 COG0642@1|root,COG2205@2|Bacteria,4P15P@976|Bacteroidetes 976|Bacteroidetes T Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,TPR_12,TPR_8 k59_1032549_1 501479.ACNW01000077_gene1793 1.31e-62 201.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Cysteine synthase cysB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_14805_1 1168034.FH5T_22130 2.66e-98 309.0 COG1452@1|root,COG1452@2|Bacteria,4NFWD@976|Bacteroidetes,2FM9F@200643|Bacteroidia 976|Bacteroidetes M Psort location OuterMembrane, score - - - - - - - - - - - - - k59_444051_1 1121396.KB893071_gene1283 7.87e-87 276.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_444056_1 1434325.AZQN01000005_gene3628 9.24e-45 166.0 COG3321@1|root,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,47XYI@768503|Cytophagia 976|Bacteroidetes Q PKS_KR - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_511699_1 1173028.ANKO01000099_gene1536 5.9e-11 68.9 COG5001@1|root,COG5001@2|Bacteria,1G3BI@1117|Cyanobacteria,1HEEG@1150|Oscillatoriales 1117|Cyanobacteria T PAS domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_4 k59_50750_2 1234364.AMSF01000080_gene3021 1.93e-31 117.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RPNH@1236|Gammaproteobacteria,1X6CD@135614|Xanthomonadales 135614|Xanthomonadales T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_837023_1 1437882.AZRU01000099_gene1122 7.88e-53 179.0 COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,1S2HE@1236|Gammaproteobacteria,1YFJR@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Fungal family of unknown function (DUF1776) - - - - - - - - - - - - adh_short k59_706469_1 1168034.FH5T_11550 4.2e-95 286.0 COG1792@1|root,COG1792@2|Bacteria,4NF14@976|Bacteroidetes,2FMWS@200643|Bacteroidia 976|Bacteroidetes M shape-determining protein MreC mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_576021_1 106648.BBLJ01000060_gene4541 1.6e-27 108.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_411897_1 1465751.W8QRJ5_9VIRU 8.65e-51 181.0 4QAPV@10239|Viruses,4QV7H@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA binding - - - - - - - - - - - - - k59_737739_1 693661.Arcve_0466 1.93e-63 221.0 arCOG05009@1|root,arCOG05009@2157|Archaea,2XZTV@28890|Euryarchaeota,246TV@183980|Archaeoglobi 183980|Archaeoglobi - - - - - - - - - - - - - - - k59_800917_1 1192124.LIG30_2987 1.86e-38 135.0 COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2VHMD@28216|Betaproteobacteria,1KFD4@119060|Burkholderiaceae 28216|Betaproteobacteria IQ KR domain - - - ko:K07535 ko00362,ko01120,ko01220,map00362,map01120,map01220 M00540 R05582 RC00154 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_800917_2 1206733.BAGC01000050_gene2675 1.2e-22 97.8 COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,4G0A5@85025|Nocardiaceae 201174|Actinobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_14824_1 563040.Saut_1513 9.7e-17 80.9 COG1287@1|root,COG1287@2|Bacteria,1R481@1224|Proteobacteria,42MNZ@68525|delta/epsilon subdivisions,2YMU3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Oligosaccharyl transferase, STT3 subunit pglB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0034645,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046872,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.99.18,2.4.99.19 ko:K07151,ko:K17251 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_14824_2 1442598.JABW01000003_gene90 7.81e-169 481.0 COG0438@1|root,COG0438@2|Bacteria,1MUYN@1224|Proteobacteria,42S1I@68525|delta/epsilon subdivisions 1224|Proteobacteria M Domain of unknown function (DUF1972) - - - - - - - - - - - - DUF1972,Glyco_trans_1_2,Glycos_transf_1 k59_14824_3 344747.PM8797T_29882 0.000316 45.8 COG0438@1|root,COG0438@2|Bacteria,2IY3T@203682|Planctomycetes 203682|Planctomycetes M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_511725_1 643562.Daes_0835 6.14e-62 200.0 COG4849@1|root,COG4849@2|Bacteria,1RDHG@1224|Proteobacteria,42WAF@68525|delta/epsilon subdivisions,2WRPU@28221|Deltaproteobacteria,2M9UD@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_935546_1 765912.Thimo_2383 6.64e-51 173.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales 135613|Chromatiales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_837034_1 1122613.ATUP01000001_gene90 2.82e-112 330.0 COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,2TSK5@28211|Alphaproteobacteria,4415K@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Serine aminopeptidase, S33 dhmA - 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1032564_1 694427.Palpr_0320 1e-112 342.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,4NI8S@976|Bacteroidetes,2FWS5@200643|Bacteroidia,22ZUE@171551|Porphyromonadaceae 976|Bacteroidetes C Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S - - 1.5.5.1 ko:K00311,ko:K00313 - - - - ko00000,ko01000 - - - DAO,ETF_QO,NAD_binding_8 k59_1032564_2 929558.SMGD1_2652 8.4e-80 254.0 COG2025@1|root,COG2086@1|root,COG2025@2|Bacteria,COG2086@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2YQDA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Electron transfer flavoprotein FAD-binding domain - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_800923_1 1120951.AUBG01000024_gene1841 2.94e-111 356.0 COG1572@1|root,COG1572@2|Bacteria,4PMQR@976|Bacteroidetes,1IK7W@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C k59_151870_1 391615.ABSJ01000039_gene1861 1.02e-46 157.0 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria,1J6UB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D AAA domain - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_184420_1 768671.ThimaDRAFT_0815 1.45e-44 162.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1WXVP@135613|Chromatiales 135613|Chromatiales P PFAM von Willebrand factor type A - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - VWA,VWA_2 k59_967950_1 986075.CathTA2_2537 5.04e-48 160.0 COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,4H9PA@91061|Bacilli 91061|Bacilli J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_967950_2 411489.CLOL250_01646 3.15e-53 172.0 COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,24FQT@186801|Clostridia,36IR5@31979|Clostridiaceae 186801|Clostridia J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_14833_1 1319815.HMPREF0202_00207 3.24e-126 373.0 COG2252@1|root,COG2252@2|Bacteria,37914@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k59_216981_1 3983.cassava4.1_020914m 2.62e-72 221.0 COG0092@1|root,2QV63@2759|Eukaryota,37ITR@33090|Viridiplantae,3GH7T@35493|Streptophyta,4JSQ4@91835|fabids 35493|Streptophyta J Belongs to the universal ribosomal protein uS3 family rps3 GO:0002181,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0031967,GO:0031975,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S3_C k59_837052_1 1307761.L21SP2_1483 7.6e-65 207.0 COG3638@1|root,COG3638@2|Bacteria,2J6UW@203691|Spirochaetes 203691|Spirochaetes P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_85193_1 402777.KB235904_gene4117 2.22e-83 263.0 COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1H97S@1150|Oscillatoriales 1117|Cyanobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_85194_1 879243.Poras_0056 9.58e-06 47.4 COG0556@1|root,COG0556@2|Bacteria,4NE6E@976|Bacteroidetes,2FNBD@200643|Bacteroidia,22W4K@171551|Porphyromonadaceae 976|Bacteroidetes L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_85194_2 1168034.FH5T_14120 3.57e-69 214.0 28H8Z@1|root,30SVU@2|Bacteria,4NY56@976|Bacteroidetes 976|Bacteroidetes S Yip1 domain - - - - - - - - - - - - Yip1 k59_902414_1 387092.NIS_0047 1.01e-19 88.6 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,42ME8@68525|delta/epsilon subdivisions,2YN4W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_902414_2 1537917.JU82_08095 6.03e-58 194.0 COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2YM7Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_771707_1 658612.MD26_08285 2.41e-69 232.0 COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,1RQW2@1236|Gammaproteobacteria 1236|Gammaproteobacteria U type IV secretory pathway, VirB4 components trbE - - ko:K20530 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - CagE_TrbE_VirB k59_411925_1 709032.Sulku_0680 3.22e-152 447.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2YMHZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_411925_2 709032.Sulku_0678 6.26e-90 267.0 COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,42UCT@68525|delta/epsilon subdivisions,2YRMZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides - - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_576057_1 1121935.AQXX01000135_gene3747 2.96e-52 177.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1XHS2@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the glutamine synthetase family - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1032594_1 484770.UFO1_3169 2.03e-45 155.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4H217@909932|Negativicutes 909932|Negativicutes I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_800947_1 387092.NIS_1691 5.14e-76 243.0 COG0582@1|root,COG0582@2|Bacteria,1N45B@1224|Proteobacteria,42QTV@68525|delta/epsilon subdivisions,2YNKX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase k59_800947_5 1278073.MYSTI_01933 8.31e-108 338.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,42MCU@68525|delta/epsilon subdivisions,2WJ3Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_184438_1 177439.DP0890 4.17e-32 118.0 COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2WNEN@28221|Deltaproteobacteria,2MK2I@213118|Desulfobacterales 28221|Deltaproteobacteria P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp k59_184438_2 331678.Cphamn1_1659 5.57e-50 162.0 COG1661@1|root,COG1661@2|Bacteria,1FF1P@1090|Chlorobi 1090|Chlorobi S Domain of unknown function (DUF296) - - - - - - - - - - - - DUF296 k59_902429_1 305900.GV64_01955 7.41e-59 195.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XIU7@135619|Oceanospirillales 135619|Oceanospirillales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_935580_1 706587.Desti_4371 4.72e-77 251.0 COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Pkinase,PocR,Sigma54_activat k59_641644_2 929558.SMGD1_0551 5.06e-54 173.0 2994D@1|root,2ZW7V@2|Bacteria,1Q2D1@1224|Proteobacteria,42VGB@68525|delta/epsilon subdivisions,2YQM6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_280401_1 566466.NOR53_3005 1.84e-91 285.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,1J58C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2939 Carboxypeptidase C (cathepsin A) - - - - - - - - - - - - Peptidase_S10 k59_772422_1 398512.JQKC01000030_gene4366 3.69e-09 59.3 COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,3WIY7@541000|Ruminococcaceae 186801|Clostridia J Metallo-beta-lactamase domain protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Ada_Zn_binding,Lactamase_B k59_772422_2 909663.KI867150_gene1151 7.09e-24 97.8 COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,2MRNX@213462|Syntrophobacterales 28221|Deltaproteobacteria P Iron/manganese superoxide dismutases, alpha-hairpin domain sodA - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_51377_1 326298.Suden_1658 1.4e-05 47.8 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2YMIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LU DNA processing protein dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_642283_1 1188256.BASI01000003_gene2710 5.64e-32 122.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_642283_2 1121033.AUCF01000026_gene2913 1.48e-75 235.0 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JR4P@204441|Rhodospirillales 204441|Rhodospirillales H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_152597_2 572544.Ilyop_1500 1.96e-70 223.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_152598_1 529818.AMSG_09242T0 7.88e-45 160.0 COG0604@1|root,KOG1198@2759|Eukaryota 2759|Eukaryota C oxidoreductase activity VAT1L - 2.3.1.85 ko:K00665 ko00061,ko01100,ko01212,ko04152,ko04910,map00061,map01100,map01212,map04152,map04910 M00082,M00083 R01404,R01624,R01626,R01706,R04355,R04428,R04430,R04533,R04534,R04535,R04536,R04537,R04543,R04544,R04566,R04568,R04725,R04726,R04952,R04953,R04954,R04956,R04957,R04959,R04960,R04962,R04963,R04965,R04967,R04968,R04970,R08159 RC00004,RC00014,RC00029,RC00039,RC00052,RC00076,RC00117,RC00120,RC00831,RC01095,RC02727,RC02728,RC02729,RC02857,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_707140_1 1121428.DESHY_110146___1 1.7e-14 70.5 COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,261GR@186807|Peptococcaceae 186801|Clostridia F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_707140_2 583355.Caka_2912 2.01e-72 231.0 COG3303@1|root,COG3303@2|Bacteria,46UP1@74201|Verrucomicrobia,3K7Z3@414999|Opitutae 414999|Opitutae C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 k59_837696_1 572544.Ilyop_1780 9.36e-119 348.0 COG0502@1|root,COG0502@2|Bacteria,379SY@32066|Fusobacteria 32066|Fusobacteria C Elongator protein 3, MiaB family, Radical SAM hydE - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - Fer4_12,Radical_SAM k59_217606_5 1121035.AUCH01000001_gene2063 0.0 961.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,2KVZR@206389|Rhodocyclales 206389|Rhodocyclales P transporter of a GTP-driven Fe(2 ) uptake system - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_217606_6 1279038.KB907347_gene3152 4.29e-22 88.6 COG1918@1|root,COG1918@2|Bacteria,1N8ZJ@1224|Proteobacteria,2UFZ6@28211|Alphaproteobacteria,2JTWS@204441|Rhodospirillales 204441|Rhodospirillales P FeoA - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_217606_7 1249627.D779_1639 8.5e-92 290.0 COG3203@1|root,COG3203@2|Bacteria,1R49B@1224|Proteobacteria,1RSFN@1236|Gammaproteobacteria,1WWR4@135613|Chromatiales 135613|Chromatiales M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_217606_8 666685.R2APBS1_1267 8.55e-110 334.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1X3FF@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_217606_9 765913.ThidrDRAFT_4145 0.0 1567.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales 135613|Chromatiales U Hydrophobe Amphiphile Efflux-1 (HAE1) - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_217606_10 722419.PH505_bv00280 6.16e-122 376.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMV2@1236|Gammaproteobacteria,2Q0UZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG0840 Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_2,sCache_2 k59_217606_11 765913.ThidrDRAFT_2806 7.81e-24 96.3 2E26Q@1|root,32XD5@2|Bacteria,1N4AD@1224|Proteobacteria,1SB7M@1236|Gammaproteobacteria,1WZ47@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_217606_12 1382303.JPOM01000001_gene69 1.4e-119 354.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,2KF2V@204458|Caulobacterales 204458|Caulobacterales C PFAM Alcohol dehydrogenase zinc-binding domain protein - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_217606_13 697282.Mettu_4017 4.16e-14 73.6 29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,1S6VD@1236|Gammaproteobacteria,1XFEE@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_217606_14 1248232.BANQ01000091_gene3223 3.96e-91 276.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria,1XVIM@135623|Vibrionales 135623|Vibrionales C COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 fpr - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_217606_15 1049564.TevJSym_bh00200 5.67e-117 337.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_217606_18 1565314.OA34_11955 1.34e-62 194.0 COG2033@1|root,COG2033@2|Bacteria,1NDWH@1224|Proteobacteria,42RSM@68525|delta/epsilon subdivisions,2YP5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Desulfoferrodoxin ferrous iron-binding - - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrodox k59_217606_19 159087.Daro_0563 1.94e-93 278.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,2VI7T@28216|Betaproteobacteria,2KUMS@206389|Rhodocyclales 206389|Rhodocyclales O C-terminal domain of 1-Cys peroxiredoxin ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_217606_20 400668.Mmwyl1_4140 1.03e-77 241.0 COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,1RQ95@1236|Gammaproteobacteria,1XJBB@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the SfsA family sfsA - - ko:K06206 - - - - ko00000 - - - SfsA k59_217606_21 1049564.TevJSym_au00630 1.51e-300 825.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1J4J5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_217606_22 1049564.TevJSym_au00640 5.78e-128 368.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1J4Y9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_217606_23 1049564.TevJSym_au00650 1.76e-31 111.0 2E5UC@1|root,330IN@2|Bacteria,1NAMZ@1224|Proteobacteria,1SCK7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Cbb3-type cytochrome oxidase component FixQ - - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_217606_26 1049564.TevJSym_ba00370 2.28e-231 649.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1J4E8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0348 Polyferredoxin ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_217606_27 765913.ThidrDRAFT_2664 9.34e-45 152.0 COG5456@1|root,COG5456@2|Bacteria,1MYXM@1224|Proteobacteria,1S6WF@1236|Gammaproteobacteria,1WY96@135613|Chromatiales 135613|Chromatiales P FixH - - - - - - - - - - - - FixH k59_942923_1 1123401.JHYQ01000007_gene545 2e-40 152.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria,461U9@72273|Thiotrichales 72273|Thiotrichales C 4Fe-4S binding domain - - - - - - - - - - - - DUF3306,Fer4 k59_744872_2 321327.CYA_2031 2.25e-19 92.4 COG1629@1|root,COG4771@2|Bacteria,1G3RJ@1117|Cyanobacteria,1H1JF@1129|Synechococcus 1117|Cyanobacteria P Transporter, TonB-dependent heme hemoglobin receptor family - - - ko:K02014,ko:K16087 - - - - ko00000,ko02000 1.B.14,1.B.14.2 - - AMIN,Plug,TonB_dep_Rec k59_452240_1 1168034.FH5T_07895 1.6e-42 149.0 COG4942@1|root,COG4942@2|Bacteria,4NH2T@976|Bacteroidetes,2FN4U@200643|Bacteroidia 976|Bacteroidetes D Peptidase, M23 family envC - - - - - - - - - - - Peptidase_M23 k59_452240_2 1168034.FH5T_07900 2.83e-39 132.0 2FH9E@1|root,3493R@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_745585_1 768671.ThimaDRAFT_4882 1.61e-93 287.0 COG3385@1|root,COG3385@2|Bacteria,1N963@1224|Proteobacteria,1SE1N@1236|Gammaproteobacteria,1WZEW@135613|Chromatiales 135613|Chromatiales L transposase activity - - - - - - - - - - - - DDE_5 k59_1041133_1 765911.Thivi_0807 8.95e-47 155.0 COG3193@1|root,COG3193@2|Bacteria,1REZG@1224|Proteobacteria,1S5K5@1236|Gammaproteobacteria,1WYDR@135613|Chromatiales 135613|Chromatiales S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_1041133_2 765913.ThidrDRAFT_3483 7.95e-10 59.3 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales 135613|Chromatiales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1008823_1 1049564.TevJSym_af00570 7.61e-150 437.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1J523@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_356056_1 1249480.B649_11695 1.49e-204 574.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,42M0K@68525|delta/epsilon subdivisions,2YMJX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU ATP synthase fliI - 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab k59_910318_1 1249480.B649_00185 6.5e-05 45.1 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42R1M@68525|delta/epsilon subdivisions,2YNZ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, iron-sulfur protein - - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_910318_2 563040.Saut_0050 1.48e-55 177.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,42SVZ@68525|delta/epsilon subdivisions,2YPE3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_484530_1 1288494.EBAPG3_14810 7.08e-39 139.0 COG0676@1|root,COG0676@2|Bacteria,1Q7VN@1224|Proteobacteria,2VKZK@28216|Betaproteobacteria,372TP@32003|Nitrosomonadales 28216|Betaproteobacteria G Belongs to the glucose-6-phosphate 1-epimerase family - - 5.1.3.15 ko:K01792 ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130 - R02739 RC00563 ko00000,ko00001,ko01000 - - - Aldose_epim k59_453366_1 1121396.KB893072_gene1224 3.29e-114 333.0 COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,42N2E@68525|delta/epsilon subdivisions,2WJFV@28221|Deltaproteobacteria,2MIP6@213118|Desulfobacterales 28221|Deltaproteobacteria S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24,DUF4339 k59_93498_1 1168034.FH5T_12565 6.05e-96 290.0 COG1703@1|root,COG1703@2|Bacteria,4NE7Y@976|Bacteroidetes,2FNHU@200643|Bacteroidia 976|Bacteroidetes E Lao Ao transport system ATPase argK - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_552499_1 1231391.AMZF01000030_gene321 1.3e-13 75.5 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,3T34Z@506|Alcaligenaceae 28216|Betaproteobacteria T factor regulatory protein rseB - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_225009_1 572544.Ilyop_1700 1.04e-106 312.0 COG0217@1|root,COG0217@2|Bacteria,3787I@32066|Fusobacteria 32066|Fusobacteria K Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_225009_2 1123284.KB899043_gene38 8.79e-20 90.5 COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,4HM35@91061|Bacilli,26P00@186821|Sporolactobacillaceae 91061|Bacilli H 5-formyltetrahydrofolate cyclo-ligase family fthC GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0030272,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_225009_3 572544.Ilyop_1701 6.3e-57 185.0 COG1573@1|root,COG1573@2|Bacteria,379EE@32066|Fusobacteria 32066|Fusobacteria L Uracil-DNA glycosylase, family 4 - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_225009_4 469615.FGAG_01580 8.3e-92 278.0 COG1235@1|root,COG1235@2|Bacteria,3783T@32066|Fusobacteria 32066|Fusobacteria S domain protein - - - - - - - - - - - - Lactamase_B,Lactamase_B_2 k59_225009_6 572544.Ilyop_1704 1.84e-33 122.0 COG1396@1|root,COG1974@1|root,COG1396@2|Bacteria,COG1974@2|Bacteria,3799F@32066|Fusobacteria 32066|Fusobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_3,Peptidase_S24 k59_484540_1 765911.Thivi_1901 6.89e-118 353.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WWF8@135613|Chromatiales 135613|Chromatiales F Belongs to the 5'-nucleotidase family - - 3.1.3.5,3.6.1.45 ko:K01081,ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_484541_1 1121949.AQXT01000002_gene300 5.61e-17 86.3 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,43WYI@69657|Hyphomonadaceae 28211|Alphaproteobacteria S L,D-transpeptidase catalytic domain - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_388786_1 388413.ALPR1_02155 2.31e-72 252.0 COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - CHASE2,CHASE5,HATPase_c,HisKA,HisKA_3,Reg_prop,Y_Y_Y k59_714508_2 381764.Fnod_1068 4.39e-12 75.1 COG1404@1|root,COG1404@2|Bacteria,2GCP4@200918|Thermotogae 200918|Thermotogae M Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8 k59_59132_1 1380600.AUYN01000001_gene2893 1.29e-24 102.0 COG1609@1|root,COG1609@2|Bacteria,4NDW6@976|Bacteroidetes,1HY65@117743|Flavobacteriia 976|Bacteroidetes K lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k59_59132_2 435591.BDI_3601 3.3e-07 51.2 COG0018@1|root,COG0018@2|Bacteria,4NE7Q@976|Bacteroidetes,2FN06@200643|Bacteroidia,22VUX@171551|Porphyromonadaceae 976|Bacteroidetes J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_943840_1 1537917.JU82_08460 8.09e-89 271.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2YMAS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Small subunit hydA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.5.1 ko:K05927 - - - - ko00000,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_943840_2 709032.Sulku_2051 6.98e-18 82.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2YM8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.5.1 ko:K05922 - - - - ko00000,ko01000 - - - NiFeSe_Hases k59_388787_1 159087.Daro_4123 1.82e-17 81.3 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,2KUM9@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_388787_2 1122197.ATWI01000011_gene405 6.88e-55 179.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,1RQNI@1236|Gammaproteobacteria,4643V@72275|Alteromonadaceae 1236|Gammaproteobacteria G Class II aldolase - - - - - - - - - - - - Aldolase_II k59_419442_1 1384056.N787_07675 7.25e-72 227.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1X3SU@135614|Xanthomonadales 135614|Xanthomonadales K Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_975562_1 1469245.JFBG01000014_gene2027 1.23e-88 275.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter TctA - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_844615_1 1121396.KB893058_gene2562 7.29e-27 122.0 COG0642@1|root,COG0834@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - DUF3365,HATPase_c,HisKA,PAS_4,Response_reg,SBP_bac_3 k59_943849_1 1175654.A0A0S0N899_9CAUD 1.5e-12 66.2 4QB1F@10239|Viruses,4QUYH@35237|dsDNA viruses no RNA stage,4QPSW@28883|Caudovirales,4QKPW@10699|Siphoviridae 10699|Siphoviridae S exonuclease activity - - - - - - - - - - - - - k59_225029_2 754477.Q7C_1249 1.72e-06 50.4 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,460CV@72273|Thiotrichales 72273|Thiotrichales G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_779815_1 1380600.AUYN01000009_gene1444 9.83e-99 308.0 COG1554@1|root,COG1554@2|Bacteria,4NEWW@976|Bacteroidetes,1HXGZ@117743|Flavobacteriia 976|Bacteroidetes G Pfam Glycosyl hydrolase family 65, N-terminal domain - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2 k59_320667_1 1121423.JONT01000003_gene1112 1.43e-71 235.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,260E3@186807|Peptococcaceae 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_584441_1 450380.JPSY01000001_gene1186 2.74e-69 231.0 29GCA@1|root,303A5@2|Bacteria,2H1W0@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1041161_1 237368.SCABRO_04028 1.75e-43 155.0 COG0644@1|root,COG0664@1|root,COG0644@2|Bacteria,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding prnA - 1.14.19.9 ko:K07058,ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_5,Trp_halogenase,cNMP_binding k59_617317_1 1007103.AFHW01000010_gene6075 2.63e-45 167.0 COG0300@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_910343_1 795666.MW7_1237 2.12e-39 152.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1K1Q0@119060|Burkholderiaceae 28216|Betaproteobacteria Q abc transporter, permease - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_714533_1 1168034.FH5T_12530 5.57e-143 417.0 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,2FNG7@200643|Bacteroidia 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_126310_1 795359.TOPB45_0494 3.8e-80 248.0 COG0846@1|root,COG0846@2|Bacteria,2GHHA@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K Sir2 family - - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_126310_2 382245.ASA_0031 6.85e-78 244.0 COG0561@1|root,COG0561@2|Bacteria,1MV02@1224|Proteobacteria,1RP1D@1236|Gammaproteobacteria,1Y49T@135624|Aeromonadales 135624|Aeromonadales S Sucrose-6F-phosphate phosphohydrolase - - - - - - - - - - - - Hydrolase_3 k59_160725_2 1232437.KL661969_gene4955 2.88e-13 66.6 2EDKE@1|root,337G8@2|Bacteria,1NDN5@1224|Proteobacteria,42WHK@68525|delta/epsilon subdivisions,2WS4A@28221|Deltaproteobacteria,2MKUW@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_520367_1 1168034.FH5T_17635 7.02e-75 231.0 COG1082@1|root,COG1082@2|Bacteria,4NIWS@976|Bacteroidetes,2FQ58@200643|Bacteroidia 976|Bacteroidetes G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N k59_192795_1 1434325.AZQN01000005_gene3651 2.75e-13 70.9 COG0745@1|root,COG0745@2|Bacteria,4NG7D@976|Bacteroidetes,47MJ5@768503|Cytophagia 976|Bacteroidetes T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_682743_1 1168034.FH5T_21950 9.59e-84 255.0 COG0061@1|root,COG0061@2|Bacteria,4NFG5@976|Bacteroidetes,2FMTM@200643|Bacteroidia 976|Bacteroidetes H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_682743_2 1168034.FH5T_21955 4.87e-41 140.0 COG0517@1|root,COG0517@2|Bacteria,4NF8G@976|Bacteroidetes,2FT2B@200643|Bacteroidia 976|Bacteroidetes S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_388840_2 869213.JCM21142_134752 3.51e-59 203.0 COG0582@1|root,COG0582@2|Bacteria,4PP5M@976|Bacteroidetes,47NSG@768503|Cytophagia 976|Bacteroidetes L PFAM Transposase, IS801 IS1294 - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_388840_3 243090.RB3999 4.79e-80 256.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_453435_1 1165841.SULAR_00275 2.33e-93 279.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2YMHA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_484597_1 551275.KB899544_gene1459 1.17e-149 454.0 COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,2VEV5@28211|Alphaproteobacteria,43ZGC@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_943896_1 385682.AFSL01000056_gene1973 3.3e-14 70.1 COG0727@1|root,COG0727@2|Bacteria,4NJH9@976|Bacteroidetes,2FT9S@200643|Bacteroidia,3XK1D@558415|Marinilabiliaceae 976|Bacteroidetes S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_943896_2 1168034.FH5T_09600 7.73e-50 167.0 COG0697@1|root,COG0697@2|Bacteria,4NNBQ@976|Bacteroidetes,2FMN9@200643|Bacteroidia 976|Bacteroidetes EG Psort location CytoplasmicMembrane, score 10.00 eamA - - - - - - - - - - - EamA k59_453448_1 1168034.FH5T_21935 1.69e-71 238.0 COG4775@1|root,COG4775@2|Bacteria,4NE6Z@976|Bacteroidetes,2FM76@200643|Bacteroidia 976|Bacteroidetes M Outer membrane protein assembly complex, YaeT protein yaeT - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_584454_1 1408473.JHXO01000014_gene4075 2.25e-129 385.0 COG0441@1|root,COG0441@2|Bacteria,4NEFT@976|Bacteroidetes,2FMAU@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_714540_2 1294142.CINTURNW_1735 2.58e-130 377.0 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,36FRF@31979|Clostridiaceae 186801|Clostridia E Histidinol phosphate phosphatase, HisJ family - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP k59_714540_3 1294142.CINTURNW_2443 2.78e-91 283.0 COG1940@1|root,COG1940@2|Bacteria,1TSMH@1239|Firmicutes,24F5X@186801|Clostridia,36HKJ@31979|Clostridiaceae 186801|Clostridia GK ROK family - - - - - - - - - - - - ROK k59_714540_4 1033738.CAEP01000088_gene1800 5.7e-57 188.0 COG0110@1|root,COG1320@1|root,COG0110@2|Bacteria,COG1320@2|Bacteria,1TQEX@1239|Firmicutes,4HAJ0@91061|Bacilli,26EVS@186818|Planococcaceae 91061|Bacilli P Maltose acetyltransferase maa - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - CM_2,Hexapep,Hexapep_2,Mac k59_877297_1 104623.Ser39006_01039 1.25e-20 93.2 COG0508@1|root,COG2267@1|root,COG0508@2|Bacteria,COG2267@2|Bacteria,1MVAI@1224|Proteobacteria,1RY6P@1236|Gammaproteobacteria,402FZ@613|Serratia 1236|Gammaproteobacteria I May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation rutD - 2.3.1.12 ko:K00627,ko:K09023 ko00010,ko00020,ko00240,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00240,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569,R09983 RC00004,RC02742,RC02769,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_4 k59_649672_1 1125863.JAFN01000001_gene771 2.14e-60 209.0 COG0464@1|root,COG0466@1|root,COG0464@2|Bacteria,COG0466@2|Bacteria,1R9P6@1224|Proteobacteria,42PYU@68525|delta/epsilon subdivisions,2WJW7@28221|Deltaproteobacteria 28221|Deltaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,Lon_C k59_844661_1 1049564.TevJSym_aa00390 1.74e-119 349.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1J4UT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_844661_2 83406.HDN1F_03980 2.93e-21 89.4 2BZAA@1|root,2ZCFW@2|Bacteria,1RCKH@1224|Proteobacteria,1SHNK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_844661_3 29850.GGTG_07706T0 1.1e-10 65.5 COG0642@1|root,KOG0519@2759|Eukaryota,39R3Q@33154|Opisthokonta,3NUCH@4751|Fungi,3QP38@4890|Ascomycota,211WW@147550|Sordariomycetes,41MBJ@639021|Magnaporthales 4751|Fungi T Phytochrome region - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_2,PHY,Response_reg k59_779872_1 439235.Dalk_3072 6.21e-91 278.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,42NJ3@68525|delta/epsilon subdivisions,2WKHX@28221|Deltaproteobacteria,2MMT7@213118|Desulfobacterales 28221|Deltaproteobacteria O Uncharacterized protein family (UPF0051) - - - ko:K07033 - - - - ko00000 - - - UPF0051 k59_552547_1 760154.Sulba_1374 1.34e-37 133.0 COG1943@1|root,COG1943@2|Bacteria,1R75U@1224|Proteobacteria 1224|Proteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_453466_1 1121405.dsmv_1587 4.79e-67 207.0 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,2MJGN@213118|Desulfobacterales 28221|Deltaproteobacteria F PFAM CMP dCMP deaminase zinc-binding comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_453466_2 1121405.dsmv_1588 1.37e-39 135.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,42SJP@68525|delta/epsilon subdivisions,2WPK0@28221|Deltaproteobacteria,2MJT3@213118|Desulfobacterales 28221|Deltaproteobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_975614_1 715451.ambt_20690 1.04e-06 57.8 COG2197@1|root,COG2199@1|root,COG2197@2|Bacteria,COG3706@2|Bacteria,1MVNV@1224|Proteobacteria,1RQHK@1236|Gammaproteobacteria,464D3@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain luxR - - - - - - - - - - - GerE,Response_reg k59_225098_1 101510.RHA1_ro06914 4.5e-68 213.0 COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4G3K3@85025|Nocardiaceae 201174|Actinobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_976588_1 1121296.JONJ01000004_gene962 2.71e-08 53.5 COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,21Z6A@1506553|Lachnoclostridium 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_296215_1 768671.ThimaDRAFT_3218 3.75e-82 256.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales 135613|Chromatiales U Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_753702_2 1165841.SULAR_03622 1.17e-17 79.3 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,42SI3@68525|delta/epsilon subdivisions,2YRUU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Membrane - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_623143_1 933262.AXAM01000034_gene1559 1.72e-95 296.0 COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales 28221|Deltaproteobacteria T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - - - - - - - - - - - k59_656081_1 765913.ThidrDRAFT_0850 6.18e-96 300.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales 135613|Chromatiales P PFAM Na Picotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_590489_1 393283.XP_007828587.1 1.63e-17 87.0 COG0642@1|root,KOG0519@2759|Eukaryota,38E1E@33154|Opisthokonta,3NXNC@4751|Fungi,3QKA6@4890|Ascomycota,213R6@147550|Sordariomycetes 4751|Fungi T Histidine kinase NIK1 GO:0000155,GO:0000156,GO:0000160,GO:0002831,GO:0002833,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0007231,GO:0007234,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010033,GO:0010570,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030447,GO:0031667,GO:0032101,GO:0032103,GO:0032104,GO:0032106,GO:0032107,GO:0032109,GO:0033554,GO:0033993,GO:0035556,GO:0036170,GO:0036180,GO:0036211,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043412,GO:0044182,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0045927,GO:0046677,GO:0048518,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071214,GO:0071236,GO:0071310,GO:0071396,GO:0071470,GO:0071704,GO:0080134,GO:0090033,GO:0097305,GO:0097306,GO:0097307,GO:0097308,GO:0104004,GO:0140096,GO:1900428,GO:1900430,GO:1900434,GO:1900436,GO:1900443,GO:1900445,GO:1901564,GO:1901700,GO:1901701 2.7.13.3 ko:K19691 ko02020,map02020 M00516 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Response_reg k59_492467_1 998088.B565_0546 8.6e-22 92.8 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RRQE@1236|Gammaproteobacteria,1Y4JE@135624|Aeromonadales 135624|Aeromonadales EH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C k59_492467_2 497321.C664_08468 8.89e-74 227.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VIBS@28216|Betaproteobacteria,2KUSB@206389|Rhodocyclales 206389|Rhodocyclales P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_590493_1 768671.ThimaDRAFT_2575 6.42e-81 253.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_884426_1 1121878.AUGL01000007_gene1090 1.24e-63 213.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2015 Alkyl sulfatase and related hydrolases BDS1 - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_688578_1 1279017.AQYJ01000022_gene2615 1.59e-31 124.0 28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria,4662R@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_688578_2 883067.HMPREF9237_00446 1.3e-19 96.3 COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3B2@85005|Actinomycetales 201174|Actinobacteria KLT serine threonine protein kinase pknB GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_852168_1 1502852.FG94_02216 3.81e-36 136.0 COG3677@1|root,COG3677@2|Bacteria,1R999@1224|Proteobacteria,2W3K1@28216|Betaproteobacteria,476UM@75682|Oxalobacteraceae 28216|Betaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,HTH_23 k59_1015360_1 1121935.AQXX01000118_gene4964 1.09e-83 267.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1XHQB@135619|Oceanospirillales 135619|Oceanospirillales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_590497_1 1168289.AJKI01000044_gene56 1.49e-54 178.0 COG3182@1|root,COG3182@2|Bacteria,4NJ7N@976|Bacteroidetes,2FPKX@200643|Bacteroidia,3XKDY@558415|Marinilabiliaceae 976|Bacteroidetes S PepSY domain protein - - - - - - - - - - - - PepSY_TM k59_296222_1 907348.TresaDRAFT_2770 9.58e-109 325.0 COG1638@1|root,COG1638@2|Bacteria,2J5GS@203691|Spirochaetes 203691|Spirochaetes G PFAM Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_296222_2 526218.Sterm_0694 8.32e-44 150.0 COG1802@1|root,COG1802@2|Bacteria,37AT1@32066|Fusobacteria 32066|Fusobacteria K Transcriptional regulator, GntR family - - - - - - - - - - - - FCD,GntR k59_786536_1 485917.Phep_3687 9.99e-47 166.0 COG3590@1|root,COG3590@2|Bacteria,4NEYB@976|Bacteroidetes,1IPA6@117747|Sphingobacteriia 976|Bacteroidetes O peptidase M13 pepO - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N k59_361859_1 314225.ELI_01405 1.95e-63 199.0 2EGQ7@1|root,33AGD@2|Bacteria,1NI1N@1224|Proteobacteria,2UJJ3@28211|Alphaproteobacteria,2K5B7@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_656106_1 749222.Nitsa_0378 2.64e-88 267.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2YN8Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_459901_1 439235.Dalk_5141 3.71e-53 176.0 arCOG07533@1|root,2ZF5I@2|Bacteria,1RB8D@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4386) - - - - - - - - - - - - DUF4386 k59_1015368_1 1192034.CAP_5407 1.87e-91 291.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42QKW@68525|delta/epsilon subdivisions,2WKH1@28221|Deltaproteobacteria,2YWTQ@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1015372_1 1121875.KB907546_gene2720 1e-85 272.0 28HMZ@1|root,2Z7WD@2|Bacteria,4P095@976|Bacteroidetes,1I89H@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_394379_1 469618.FVAG_00717 1e-116 370.0 COG1629@1|root,COG4771@2|Bacteria,37971@32066|Fusobacteria 32066|Fusobacteria P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_394379_2 1319815.HMPREF0202_00559 8.32e-16 75.5 COG0810@1|root,COG0810@2|Bacteria,37ANH@32066|Fusobacteria 32066|Fusobacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_263326_1 396588.Tgr7_1069 1.12e-82 254.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales 135613|Chromatiales S PFAM Radical SAM - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_100184_1 998088.B565_2887 1.78e-17 89.0 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1Y46M@135624|Aeromonadales 135624|Aeromonadales MU AAA domain exeA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_329159_1 502025.Hoch_1780 5.77e-69 232.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,2YUAP@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_231025_1 96561.Dole_2366 8.26e-45 163.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria,2MJ7S@213118|Desulfobacterales 28221|Deltaproteobacteria I acyl-CoA dehydrogenase - - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1563_1 930166.CD58_24555 8.11e-51 170.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_525196_1 1537917.JU82_01230 8.1e-138 398.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2YM99@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Saccharopine dehydrogenase LYS1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_525196_2 1172190.M947_04645 3.13e-121 355.0 COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,42RC6@68525|delta/epsilon subdivisions,2YR0K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K helix_turn_helix, arabinose operon control protein - - - ko:K13652 - - - - ko00000,ko03000 - - - GyrI-like,HTH_18 k59_525196_3 1442598.JABW01000028_gene1000 6.91e-77 242.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2YMWB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Biotin carboxylase pycA - 6.3.4.14,6.4.1.1,6.4.1.2 ko:K01959,ko:K01961 ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00376,M00620 R00344,R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_786557_1 1168034.FH5T_05490 1.38e-166 480.0 COG0481@1|root,COG0481@2|Bacteria,4NEJ9@976|Bacteroidetes,2FM9V@200643|Bacteroidia 976|Bacteroidetes M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_67312_1 1150621.SMUL_1671 1.27e-78 246.0 COG1149@1|root,COG1149@2|Bacteria,1MVPB@1224|Proteobacteria,42MJ5@68525|delta/epsilon subdivisions 1224|Proteobacteria C Cobyrinic acid ac-diamide synthase - - - - - - - - - - - - CbiA,Fer4 k59_67312_2 744872.Spica_0704 1.95e-12 63.5 COG1433@1|root,COG1433@2|Bacteria 2|Bacteria S nitrogen fixation VPA0323 - - - - - - - - - - - Nitro_FeMo-Co k59_950169_2 1537917.JU82_01110 6.17e-71 217.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,42RJX@68525|delta/epsilon subdivisions,2YP8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_426877_1 491915.Aflv_2133 1.63e-90 290.0 COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,4HAMK@91061|Bacilli,21W6G@150247|Anoxybacillus 91061|Bacilli E Bacterial extracellular solute-binding proteins, family 5 Middle oppA - - ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_426877_2 697303.Thewi_0698 1.69e-114 340.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FJK@68295|Thermoanaerobacterales 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component oppB - - ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_426877_3 545693.BMQ_0707 1.58e-95 291.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4H9PZ@91061|Bacilli,1ZC9B@1386|Bacillus 91061|Bacilli EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components oppC - - ko:K15582,ko:K16201 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439,M00566 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.2,3.A.1.5.25 - - BPD_transp_1,OppC_N k59_426877_4 526218.Sterm_3854 2.94e-51 172.0 COG0444@1|root,COG0444@2|Bacteria,378P9@32066|Fusobacteria 32066|Fusobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_492500_1 865937.Gilli_1039 1.21e-77 242.0 COG0381@1|root,COG0381@2|Bacteria,4NFTG@976|Bacteroidetes,1HZTF@117743|Flavobacteriia,2P7CG@244698|Gillisia 976|Bacteroidetes M UDP-N-acetylglucosamine 2-epimerase neuC - 3.2.1.183,3.2.1.184 ko:K08068,ko:K18429 ko00520,map00520 - R10187 RC00005,RC00288 ko00000,ko00001,ko01000 - - - Epimerase_2 k59_165672_1 765912.Thimo_3326 2.71e-142 429.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWXC@135613|Chromatiales 135613|Chromatiales G Belongs to the PEP-utilizing enzyme family - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_394823_1 743299.Acife_0163 7.73e-66 213.0 COG0732@1|root,COG0732@2|Bacteria,1PFJI@1224|Proteobacteria,1T6EX@1236|Gammaproteobacteria,2NE0I@225057|Acidithiobacillales 225057|Acidithiobacillales L Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_394823_2 641149.HMPREF9016_00220 8.26e-35 120.0 2E3GE@1|root,32YF6@2|Bacteria,1N7MX@1224|Proteobacteria,2VWDH@28216|Betaproteobacteria 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2188) - - - - - - - - - - - - DUF2188 k59_67738_1 469615.FGAG_00565 1.25e-43 146.0 COG5341@1|root,COG5341@2|Bacteria,37A06@32066|Fusobacteria 32066|Fusobacteria S NusG domain II - - - - - - - - - - - - NusG_II k59_67738_2 1319815.HMPREF0202_00534 8.99e-44 154.0 COG0415@1|root,COG0415@2|Bacteria,37BMG@32066|Fusobacteria 32066|Fusobacteria L FAD binding domain of DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase k59_1015754_1 1165841.SULAR_06838 4.43e-66 222.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2YMW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_296670_1 411902.CLOBOL_02615 7.44e-51 170.0 COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia,21Z8V@1506553|Lachnoclostridium 186801|Clostridia C Malate/L-lactate dehydrogenase - - 1.1.1.130 ko:K08092 ko00040,ko00053,map00040,map00053 - R02637,R02639 RC00238 ko00000,ko00001,ko01000 - - - Ldh_2 k59_296670_2 221988.MS0072 2.67e-53 185.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria,1Y7BJ@135625|Pasteurellales 135625|Pasteurellales S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_427282_1 469618.FVAG_01466 1.17e-66 211.0 COG0462@1|root,COG0462@2|Bacteria,3784I@32066|Fusobacteria 32066|Fusobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_427282_2 1232410.KI421412_gene318 9.02e-53 179.0 COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2WKT8@28221|Deltaproteobacteria,43S3R@69541|Desulfuromonadales 28221|Deltaproteobacteria H Galactose-1-phosphate uridyl transferase, N-terminal domain galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - DUF4921,GalP_UDP_tr_C,GalP_UDP_transf k59_884829_2 387093.SUN_1683 8.82e-86 272.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,42MUY@68525|delta/epsilon subdivisions,2YMZF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E PFAM peptidase M3A and M3B thimet oligopeptidase F prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_460398_1 519989.ECTPHS_01924 2.26e-80 263.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_460400_1 1249480.B649_08370 1.3e-76 240.0 COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,43D9T@68525|delta/epsilon subdivisions,2YPAD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C FAD binding domain - - 1.3.1.111,1.3.1.83 ko:K10960 ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110 - R02063,R08754,R08755,R08756,R11226,R11518 RC00212,RC00522,RC01823 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_787043_1 387092.NIS_0729 2.4e-78 243.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,42MPM@68525|delta/epsilon subdivisions,2YMX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_787043_2 1165841.SULAR_05473 5.91e-109 323.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2YME5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_525698_1 477184.KYC_22581 4.09e-79 245.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VMBX@28216|Betaproteobacteria,3T1V3@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_852649_1 1218103.CIN01S_09_03240 1.95e-30 114.0 COG1704@1|root,COG1704@2|Bacteria,4NMP9@976|Bacteroidetes,1I1WR@117743|Flavobacteriia,3ZQEP@59732|Chryseobacterium 976|Bacteroidetes S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_852649_2 688270.Celal_3703 0.000166 50.8 2A420@1|root,30SKQ@2|Bacteria,4P05U@976|Bacteroidetes,1IM81@117743|Flavobacteriia,1FAC4@104264|Cellulophaga 976|Bacteroidetes - - - - - - - - - - - - - - - k59_852649_3 1095747.HMPREF1049_0586 1.09e-101 306.0 COG0130@1|root,COG0130@2|Bacteria,378NK@32066|Fusobacteria 32066|Fusobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_852649_4 572544.Ilyop_0445 0.0 1081.0 COG1217@1|root,COG1217@2|Bacteria,378B5@32066|Fusobacteria 32066|Fusobacteria T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_852649_5 572544.Ilyop_0413 7.12e-204 577.0 COG1875@1|root,COG1875@2|Bacteria,379EH@32066|Fusobacteria 32066|Fusobacteria T Large family of predicted nucleotide-binding domains - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_852649_6 1380391.JIAS01000020_gene1691 5.43e-05 52.8 COG2885@1|root,COG2885@2|Bacteria,1RJ3P@1224|Proteobacteria,2U9ZX@28211|Alphaproteobacteria,2JSTE@204441|Rhodospirillales 204441|Rhodospirillales M COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins - - - - - - - - - - - - OmpA k59_852649_7 1286171.EAL2_c21670 1.89e-94 289.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia 186801|Clostridia F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine guaD - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_558466_1 990073.ATHU01000001_gene1410 1.51e-18 90.5 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2YMHD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_492927_1 1168034.FH5T_10065 5.76e-97 292.0 COG0137@1|root,COG0137@2|Bacteria,4NE3R@976|Bacteroidetes,2FMRA@200643|Bacteroidia 976|Bacteroidetes E argininosuccinate synthase argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_492927_2 1168034.FH5T_10070 7e-122 351.0 COG1670@1|root,COG1670@2|Bacteria,4PKMC@976|Bacteroidetes,2G07D@200643|Bacteroidia 976|Bacteroidetes J acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_492927_3 1168034.FH5T_10075 0.000286 42.0 COG1438@1|root,COG1438@2|Bacteria,4NSSS@976|Bacteroidetes,2FR3Q@200643|Bacteroidia 976|Bacteroidetes K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k59_852658_1 1238450.VIBNISOn1_770041 4.19e-34 121.0 COG1733@1|root,COG1733@2|Bacteria,1N414@1224|Proteobacteria,1SZ1S@1236|Gammaproteobacteria 1236|Gammaproteobacteria K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_623606_1 1336245.JAGO01000016_gene2169 1.75e-14 72.8 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1XK3U@135619|Oceanospirillales 135619|Oceanospirillales I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_623606_2 1042375.AFPL01000023_gene1657 3.58e-27 112.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,4649V@72275|Alteromonadaceae 1236|Gammaproteobacteria I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_819728_1 572544.Ilyop_0887 2.37e-235 655.0 COG0004@1|root,COG0004@2|Bacteria,37ANZ@32066|Fusobacteria 2|Bacteria P Ammonium Transporter Family amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,P-II k59_335042_1 1168034.FH5T_09325 6.13e-59 186.0 COG1309@1|root,COG1309@2|Bacteria,4NNNT@976|Bacteroidetes,2FS2Z@200643|Bacteroidia 976|Bacteroidetes K transcriptional regulator, TetR family qacR - - - - - - - - - - - TetR_C_5,TetR_N k59_73064_1 1168034.FH5T_14400 2.69e-68 216.0 COG4213@1|root,COG4213@2|Bacteria,4NNBW@976|Bacteroidetes,2FWT8@200643|Bacteroidia 976|Bacteroidetes G Periplasmic binding protein domain - - - ko:K10543 ko02010,map02010 M00215 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.4 - - Peripla_BP_4 k59_595705_1 1342299.Z947_1530 1.07e-29 117.0 COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2TSR9@28211|Alphaproteobacteria,3ZXUA@60136|Sulfitobacter 28211|Alphaproteobacteria E Ornithine cyclodeaminase/mu-crystallin family - - 1.4.1.1,1.5.1.1,4.3.1.12 ko:K01750,ko:K19244,ko:K19743 ko00250,ko00310,ko00330,ko00430,ko00960,ko01100,ko01110,ko01130,ko01230,map00250,map00310,map00330,map00430,map00960,map01100,map01110,map01130,map01230 - R00396,R00671,R01246,R01249,R02201,R02203 RC00008,RC00135,RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_1020737_1 1249627.D779_0040 9.42e-49 162.0 COG0457@1|root,COG0457@2|Bacteria,1RESK@1224|Proteobacteria,1S41N@1236|Gammaproteobacteria,1WYBB@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2 k59_923262_1 572544.Ilyop_0604 6.54e-85 258.0 COG0569@1|root,COG0569@2|Bacteria,379BC@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score 8.96 - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_923262_2 1354303.M917_1206 7.22e-07 53.5 COG1414@1|root,COG1414@2|Bacteria,1RAQI@1224|Proteobacteria,1S7IF@1236|Gammaproteobacteria,3NSI0@468|Moraxellaceae 1236|Gammaproteobacteria K Bacterial transcriptional regulator - - - ko:K20539 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - HTH_IclR,IclR k59_923262_3 1304284.L21TH_0089 5.09e-210 595.0 COG2610@1|root,COG2610@2|Bacteria,1TQ14@1239|Firmicutes,248PQ@186801|Clostridia,36ESW@31979|Clostridiaceae 186801|Clostridia EG Gluconate - - - ko:K03299,ko:K06155,ko:K06157 - - - - ko00000,ko02000 2.A.8,2.A.8.1.2,2.A.8.1.4 - iHN637.CLJU_RS05690,iHN637.CLJU_RS13905 GntP_permease k59_923262_4 293826.Amet_1268 1.07e-174 503.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,36DS1@31979|Clostridiaceae 186801|Clostridia EG Belongs to the IlvD Edd family ilvD3 - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_531034_1 857293.CAAU_2714 4.67e-08 54.3 COG5001@1|root,COG5001@2|Bacteria,1VRUY@1239|Firmicutes,25EFD@186801|Clostridia,36UNW@31979|Clostridiaceae 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - CHASE,GGDEF k59_531034_2 1121342.AUCO01000017_gene2885 2.22e-60 196.0 COG0639@1|root,COG0639@2|Bacteria,1UYWK@1239|Firmicutes,25DVG@186801|Clostridia,36UF7@31979|Clostridiaceae 186801|Clostridia T Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 k59_531034_3 572544.Ilyop_0782 3.85e-36 125.0 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - ko:K03892,ko:K21903 - - - - ko00000,ko03000 - - - HTH_5 k59_531034_4 1210884.HG799462_gene8246 4.07e-75 233.0 COG0580@1|root,COG0580@2|Bacteria,2IZDN@203682|Planctomycetes 203682|Planctomycetes U Belongs to the MIP aquaporin (TC 1.A.8) family - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP k59_531034_5 572544.Ilyop_0784 2.77e-273 761.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,378ZZ@32066|Fusobacteria 32066|Fusobacteria P Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,Rhodanese k59_531034_6 1504981.KO116_3914 1.42e-23 108.0 COG2199@1|root,COG3706@2|Bacteria,1MVWM@1224|Proteobacteria,1RR1M@1236|Gammaproteobacteria,1XJR6@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF,Hpt,Response_reg k59_531034_7 1526927.Plano_1475 1.82e-157 467.0 COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,4HCRI@91061|Bacilli 91061|Bacilli C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - DUF1499,Pyr_redox_2,Pyr_redox_dim k59_367332_1 929558.SMGD1_1944 2.43e-24 97.1 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2YPEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E D,D-heptose 1,7-bisphosphate phosphatase gmhB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - iIT341.HP0860 HAD_2,Hydrolase_like,PNK3P k59_367332_2 1150621.SMUL_0597 3.68e-47 157.0 COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2YQ20@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EJ GlutRNAGln amidotransferase subunit D - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_367332_3 563040.Saut_1572 5.03e-70 232.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2YMI5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P cation transport ATPase ccoI - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_39028_1 202955.BBND01000021_gene2937 6.82e-39 165.0 COG1672@1|root,COG1672@2|Bacteria,1QKUB@1224|Proteobacteria,1TIZM@1236|Gammaproteobacteria,3NRD1@468|Moraxellaceae 1236|Gammaproteobacteria S PFAM Archaeal ATPase - - - - - - - - - - - - - k59_790970_1 1223410.KN050846_gene2306 1.52e-76 243.0 COG0457@1|root,COG0457@2|Bacteria,4NF7U@976|Bacteroidetes,1HWMR@117743|Flavobacteriia 976|Bacteroidetes S Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_8 k59_498233_1 1286631.X805_30790 7.22e-49 167.0 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,1KIZ7@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_923278_1 644107.SL1157_1787 4.38e-40 138.0 COG0589@1|root,COG0589@2|Bacteria,1RDMJ@1224|Proteobacteria,2U769@28211|Alphaproteobacteria,4NBZG@97050|Ruegeria 28211|Alphaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_335077_1 243233.MCA2891 1.43e-12 73.6 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1XE8E@135618|Methylococcales 135618|Methylococcales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_236282_2 572544.Ilyop_1871 1.07e-22 91.7 2CE3J@1|root,32RZ2@2|Bacteria,37ASU@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_236282_3 572544.Ilyop_1879 1.09e-57 190.0 COG2887@1|root,COG2887@2|Bacteria 2|Bacteria L Belongs to the helicase family. UvrD subfamily - - - ko:K07465 - - - - ko00000 - - - FtsK_SpoIIIE,PDDEXK_1 k59_236282_4 203119.Cthe_0206 1.53e-88 294.0 COG0210@1|root,COG0210@2|Bacteria,1UQI9@1239|Firmicutes,24BXT@186801|Clostridia,3WI0N@541000|Ruminococcaceae 186801|Clostridia L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_431715_1 1168034.FH5T_21725 3.15e-75 237.0 COG0472@1|root,COG0472@2|Bacteria,4NGKM@976|Bacteroidetes,2FM86@200643|Bacteroidia 976|Bacteroidetes M Psort location CytoplasmicMembrane, score 10.00 mraY2 - - - - - - - - - - - Glycos_transf_4 k59_106215_1 1537917.JU82_06325 6.34e-36 128.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,42MJU@68525|delta/epsilon subdivisions,2YM7H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M UTP-glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0646 NTP_transferase k59_106215_2 485916.Dtox_4144 1.59e-30 119.0 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,248WV@186801|Clostridia,261IW@186807|Peptococcaceae 186801|Clostridia M sugar transferase - - 2.7.8.6 ko:K00996 - - - - ko00000,ko01000,ko01005 - - - Bac_transf,CoA_binding_3 k59_399648_1 1347393.HG726023_gene3428 2.86e-51 184.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,2FQQ7@200643|Bacteroidia,4AM6I@815|Bacteroidaceae 976|Bacteroidetes C Proline dehydrogenase pruA - 1.2.1.3,1.2.1.88,1.5.5.2 ko:K00128,ko:K00294,ko:K13821 ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00245,R00264,R00631,R00707,R00708,R00710,R00904,R01253,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04444,R04445,R04506,R04903,R05050,R05051,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00083,RC00186,RC00216,RC00218,RC00242,RC00255,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000,ko03000 - - - Aldedh,Pro_dh k59_106217_1 1121912.AUHD01000010_gene3598 1.34e-121 356.0 COG2089@1|root,COG2089@2|Bacteria,4NEKD@976|Bacteroidetes,1I0MG@117743|Flavobacteriia 976|Bacteroidetes M COG2089 Sialic acid synthase neuB - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_726282_1 933262.AXAM01000077_gene1703 1.38e-59 198.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria,2MJ2C@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_758844_1 999541.bgla_2g10690 7.4e-36 139.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,1JZUU@119060|Burkholderiaceae 28216|Betaproteobacteria Q amino acid adenylation domain protein - - - ko:K04780 ko01053,map01053 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_1020773_1 1168034.FH5T_17480 7.08e-91 283.0 COG3501@1|root,COG3501@2|Bacteria,4NFPB@976|Bacteroidetes,2FPUE@200643|Bacteroidia 976|Bacteroidetes S Rhs element Vgr protein - - - - - - - - - - - - Phage_GPD k59_465598_1 457421.CBFG_03315 1.79e-91 275.0 COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,249YG@186801|Clostridia,269XI@186813|unclassified Clostridiales 186801|Clostridia I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_465598_2 1408439.JHXW01000016_gene62 1.01e-31 121.0 COG2407@1|root,COG2407@2|Bacteria 2|Bacteria G Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - - - - - - - - - - Fucose_iso_C k59_595753_1 1165841.SULAR_05603 1.18e-63 209.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,42M78@68525|delta/epsilon subdivisions,2YMR1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_335097_1 1454004.AW11_02473 9.55e-25 100.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,1KQHS@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Cysteine-rich domain glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_335097_2 640081.Dsui_3414 4.53e-36 134.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,2KUSX@206389|Rhodocyclales 206389|Rhodocyclales C FAD binding glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_595762_1 566466.NOR53_2419 6.42e-28 114.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1J8KD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_39063_1 243233.MCA2846 1.76e-07 51.2 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1XFDT@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_39063_2 765912.Thimo_1243 1.22e-39 150.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_988203_1 929558.SMGD1_1633 1.29e-37 134.0 2AK36@1|root,31ASY@2|Bacteria,1Q62K@1224|Proteobacteria,42W11@68525|delta/epsilon subdivisions,2YQDG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF2393) - - - - - - - - - - - - DUF2393 k59_988203_2 1172190.M947_07720 3.06e-49 164.0 2AJSF@1|root,30P8S@2|Bacteria,1PCR0@1224|Proteobacteria,42WCR@68525|delta/epsilon subdivisions,2YSXN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF2393) - - - - - - - - - - - - DUF2393 k59_988203_3 563040.Saut_1857 7.03e-179 504.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,42PX9@68525|delta/epsilon subdivisions,2YN2U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Radical SAM protein - - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_988203_4 929558.SMGD1_1636 1.7e-57 191.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2YMF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran k59_171288_1 1123237.Salmuc_03572 1.04e-10 61.6 COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain alaS2 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K07050 - - - - ko00000,ko01000,ko03016 - - - tRNA-synt_2c,tRNA_SAD k59_171288_2 1479235.KK366039_gene3042 1.91e-09 59.7 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XH9G@135619|Oceanospirillales 135619|Oceanospirillales V ABC transporter - - - ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_693973_1 1195236.CTER_2912 6.16e-78 241.0 COG1082@1|root,COG1082@2|Bacteria,1TRGF@1239|Firmicutes,248GM@186801|Clostridia 186801|Clostridia G TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_693973_2 565034.BHWA1_02079 1.24e-47 164.0 COG1802@1|root,COG1802@2|Bacteria,2J7H2@203691|Spirochaetes 203691|Spirochaetes K PFAM Bacterial regulatory proteins, gntR family - - - - - - - - - - - - FCD,GntR k59_693973_3 1348635.BBJY01000010_gene1331 1.34e-201 564.0 COG1312@1|root,COG1312@2|Bacteria,1MWYD@1224|Proteobacteria,1RR0Q@1236|Gammaproteobacteria,1XU49@135623|Vibrionales 135623|Vibrionales G Catalyzes the dehydration of D-mannonate uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - UxuA k59_1020785_1 1207075.PputUW4_02307 1.01e-86 279.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_73132_1 572544.Ilyop_1394 1.7e-112 327.0 COG4149@1|root,COG4149@2|Bacteria,378XY@32066|Fusobacteria 32066|Fusobacteria P Binding-protein-dependent transport system inner membrane component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_73132_2 931626.Awo_c27680 2.12e-08 55.8 COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,249VA@186801|Clostridia,25WJQ@186806|Eubacteriaceae 186801|Clostridia P Bacterial extracellular solute-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_988211_1 998088.B565_1416 1.16e-27 111.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1Y3HX@135624|Aeromonadales 135624|Aeromonadales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_595774_1 392500.Swoo_0577 9.93e-13 73.9 COG4932@1|root,COG5384@1|root,COG5644@1|root,COG4932@2|Bacteria,COG5384@2|Bacteria,COG5644@2|Bacteria,1QUEG@1224|Proteobacteria,1T4AQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_498276_2 247490.KSU1_B0085 7.64e-11 67.8 COG5184@1|root,COG5184@2|Bacteria,2J3XT@203682|Planctomycetes 203682|Planctomycetes DZ Putative metal-binding motif - - - - - - - - - - - - Cu-binding_MopE k59_595783_1 1232447.BAHW02000049_gene3025 7.81e-56 186.0 COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,268A6@186813|unclassified Clostridiales 186801|Clostridia M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_268255_2 749222.Nitsa_0590 6.66e-60 191.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,42MPM@68525|delta/epsilon subdivisions,2YMX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_171310_1 1317124.DW2_03019 1.83e-97 293.0 COG0725@1|root,COG0725@2|Bacteria,1NACV@1224|Proteobacteria,2U20P@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_498288_1 1304275.C41B8_04656 2.09e-40 150.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II JD73_00810 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C_2,PP-binding k59_367404_1 1168034.FH5T_04100 9.98e-109 326.0 COG1073@1|root,COG1073@2|Bacteria,4NFCA@976|Bacteroidetes,2FP8B@200643|Bacteroidia 976|Bacteroidetes S PS-10 peptidase S37 - - - - - - - - - - - - Peptidase_S37 k59_758879_1 1165841.SULAR_05533 7.35e-67 218.0 COG3203@1|root,COG3203@2|Bacteria,1QVBP@1224|Proteobacteria,42M72@68525|delta/epsilon subdivisions,2YNNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M outer membrane porin, OprD family - - - - - - - - - - - - OprD k59_889511_1 1165841.SULAR_06553 9.63e-39 140.0 COG3660@1|root,COG3660@2|Bacteria,1RC47@1224|Proteobacteria,42R32@68525|delta/epsilon subdivisions,2YNVT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mitochondrial fission ELM1 - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_726325_1 314225.ELI_14900 8.63e-131 379.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_988237_1 1232437.KL661988_gene81 1.64e-63 209.0 COG2204@1|root,COG2206@1|root,COG2204@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria,2MHS0@213118|Desulfobacterales 28221|Deltaproteobacteria T HD domain - - - - - - - - - - - - GAF_2,GAF_3,GGDEF,HD,Response_reg k59_39103_1 1122612.AUBA01000009_gene2040 1.38e-47 163.0 COG3217@1|root,COG3217@2|Bacteria,1MXN2@1224|Proteobacteria,2U7IM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Fe-S protein - - - ko:K07140 - - - - ko00000 - - - MOSC,MOSC_N k59_758891_2 118168.MC7420_6146 2.2e-39 144.0 COG1403@1|root,COG1403@2|Bacteria,1G2XW@1117|Cyanobacteria,1H9JX@1150|Oscillatoriales 1117|Cyanobacteria L HNH endonuclease - - - - - - - - - - - - HNH,HNH_5,RRXRR k59_595806_1 869213.JCM21142_104498 5e-53 188.0 COG4775@1|root,COG4775@2|Bacteria,4NDYT@976|Bacteroidetes,47MWA@768503|Cytophagia 976|Bacteroidetes M CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2 k59_694787_1 518766.Rmar_0266 1.31e-33 123.0 COG0730@1|root,COG0730@2|Bacteria,4NFWP@976|Bacteroidetes,1FJ28@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_694787_2 1112217.PPL19_06250 1.04e-34 127.0 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0491 Zn-dependent hydrolases, including glyoxylases blh - - - - - - - - - - - Lactamase_B k59_662683_1 1168034.FH5T_08155 1.62e-130 384.0 COG0589@1|root,COG0589@2|Bacteria,4NHBB@976|Bacteroidetes,2FPV4@200643|Bacteroidia 976|Bacteroidetes T universal stress protein uspA - - - - - - - - - - - DUF2007,Usp k59_924124_1 323261.Noc_1204 1.45e-50 177.0 COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,1S29W@1236|Gammaproteobacteria,1WYC1@135613|Chromatiales 135613|Chromatiales L Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_368245_1 446466.Cfla_1118 4.85e-121 360.0 COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4F0KR@85016|Cellulomonadaceae 201174|Actinobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_825469_3 572544.Ilyop_0144 1.02e-287 823.0 COG1033@1|root,COG1033@2|Bacteria 2|Bacteria S growth of symbiont in host cell hpnN - - ko:K07003 - - - - ko00000 - - - MMPL k59_825469_4 1121904.ARBP01000004_gene850 4.67e-28 115.0 COG2267@1|root,COG2267@2|Bacteria,4NFDA@976|Bacteroidetes,47NH1@768503|Cytophagia 976|Bacteroidetes I Serine aminopeptidase, S33 - - 1.11.1.10,3.4.11.5 ko:K00433,ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_825469_5 340177.Cag_0187 7.69e-121 350.0 COG0588@1|root,COG0588@2|Bacteria,1FDHF@1090|Chlorobi 1090|Chlorobi F Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_432550_1 1242864.D187_007529 1.13e-09 59.3 COG0300@1|root,COG0300@2|Bacteria,1QU6Z@1224|Proteobacteria,43EAQ@68525|delta/epsilon subdivisions,2X7T9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_432550_2 1316936.K678_12961 1.87e-21 93.6 COG0406@1|root,COG0406@2|Bacteria,1RB0S@1224|Proteobacteria,2UEW2@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_536932_1 765914.ThisiDRAFT_1142 3.69e-118 352.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_8290_1 1535422.ND16A_3875 4.2e-35 137.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,2Q73E@267889|Colwelliaceae 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_830120_1 1121035.AUCH01000004_gene429 6.41e-82 271.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_699429_1 1101195.Meth11DRAFT_2209 2.64e-80 256.0 2AT3Q@1|root,31IJS@2|Bacteria,1RIYP@1224|Proteobacteria,2W2W1@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4401) - - - - - - - - - - - - DUF4401 k59_830122_1 1168034.FH5T_05525 1.13e-56 182.0 COG3952@1|root,COG3952@2|Bacteria,4NH8Q@976|Bacteroidetes,2FPQS@200643|Bacteroidia 976|Bacteroidetes S Lipid A Biosynthesis domain protein - - - - - - - - - - - - LAB_N k59_830122_2 1168034.FH5T_05520 5.37e-19 83.6 COG0571@1|root,COG0571@2|Bacteria,4NE0N@976|Bacteroidetes,2FMV3@200643|Bacteroidia 976|Bacteroidetes J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_602012_1 1121015.N789_13500 2.99e-21 95.9 COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,1SHAC@1236|Gammaproteobacteria,1X3IB@135614|Xanthomonadales 135614|Xanthomonadales S Dak2 - - - ko:K07030 - - - - ko00000 - - - Dak2,DegV k59_994154_1 177437.HRM2_21630 6.99e-119 360.0 COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MJ4K@213118|Desulfobacterales 28221|Deltaproteobacteria CK PFAM Acetyl-CoA hydrolase transferase - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1 k59_78430_1 1088868.CIN_14650 2.18e-09 59.7 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2JQ4K@204441|Rhodospirillales 204441|Rhodospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_78430_2 223926.28807162 3.01e-28 108.0 COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,1S5XU@1236|Gammaproteobacteria,1XWWH@135623|Vibrionales 135623|Vibrionales S Belongs to the UPF0260 family VV2402 - - ko:K09160 - - - - ko00000 - - - CxxCxxCC k59_764494_1 1280944.HY17_19030 2.81e-50 181.0 COG1215@1|root,COG2604@1|root,COG1215@2|Bacteria,COG2604@2|Bacteria,1QVTJ@1224|Proteobacteria,2TXTU@28211|Alphaproteobacteria,43ZTK@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Glycosyl transferase family 2 - - - ko:K13002 - - - - ko00000,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_1,Glycos_transf_2 k59_536942_1 95619.PM1_0227215 8.82e-39 144.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein with a C-terminal ATPase domain algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_177363_1 314278.NB231_07482 2.45e-97 302.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW7H@135613|Chromatiales 135613|Chromatiales V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_895729_1 765913.ThidrDRAFT_2661 1.3e-55 182.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1WWRW@135613|Chromatiales 135613|Chromatiales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_504667_1 1220534.B655_0403 3.56e-06 48.9 COG0708@1|root,arCOG02207@2157|Archaea,2XVJ5@28890|Euryarchaeota,23PEV@183925|Methanobacteria 183925|Methanobacteria L PFAM Endonuclease Exonuclease phosphatase - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_504667_2 1197719.A464_3810 9.45e-90 270.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,3ZJVS@590|Salmonella 1236|Gammaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186 Pribosyltran k59_602029_1 497321.C664_07268 3.02e-36 128.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VK6R@28216|Betaproteobacteria,2KVYG@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11,Fer4_4 k59_504676_1 1265505.ATUG01000001_gene4676 5.27e-47 161.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42NVJ@68525|delta/epsilon subdivisions,2WJN1@28221|Deltaproteobacteria,2MIXE@213118|Desulfobacterales 28221|Deltaproteobacteria E TOBE domain - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_504676_2 1188252.AJYK01000065_gene2605 2.04e-16 77.0 COG0395@1|root,COG0395@2|Bacteria,1MUT9@1224|Proteobacteria,1RZHT@1236|Gammaproteobacteria,1XTKM@135623|Vibrionales 135623|Vibrionales P COG0395 ABC-type sugar transport system, permease component - - - ko:K17317 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - BPD_transp_1 k59_536954_1 479433.Caci_7859 1.56e-13 70.9 COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_536954_2 1380387.JADM01000019_gene3279 9.16e-13 66.2 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1XJWK@135619|Oceanospirillales 135619|Oceanospirillales E glycine cleavage system - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_177379_1 666681.M301_0034 1.98e-120 354.0 COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,2W11Y@28216|Betaproteobacteria,2KKMU@206350|Nitrosomonadales 206350|Nitrosomonadales E 4-Hydroxyphenylpyruvate dioxygenase - - - - - - - - - - - - - k59_341233_1 396588.Tgr7_0692 8.48e-71 225.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_273117_1 765912.Thimo_3624 1.73e-70 226.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1WXE8@135613|Chromatiales 135613|Chromatiales S PFAM Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_895752_1 999419.HMPREF1077_00010 6.45e-55 194.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia,22W33@171551|Porphyromonadaceae 976|Bacteroidetes M Tricorn protease homolog - - - - - - - - - - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_731165_1 644968.DFW101_2850 8.3e-60 199.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MAU1@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_209861_1 886293.Sinac_7188 1.51e-12 73.2 COG0568@1|root,COG0568@2|Bacteria,2IY72@203682|Planctomycetes 203682|Planctomycetes K TIGRFAM RNA polymerase sigma factor, sigma-70 family - - - ko:K03086,ko:K03093 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4 k59_862302_2 768671.ThimaDRAFT_1056 0.000261 44.7 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1WW5P@135613|Chromatiales 135613|Chromatiales J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_830146_1 96561.Dole_1473 1.81e-101 309.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,42PNB@68525|delta/epsilon subdivisions,2WKT7@28221|Deltaproteobacteria,2MI6D@213118|Desulfobacterales 28221|Deltaproteobacteria IQ synthetase - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_78451_1 471853.Bcav_1906 1.02e-125 370.0 COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria 201174|Actinobacteria E Belongs to the class-II DAHP synthase family aroG GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0022607,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.5.1.54 ko:K01626,ko:K16019 ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01051,map01100,map01110,map01130,map01230,map02024 M00022 R01826,R06591 RC00435,RC01556 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2178c DAHP_synth_2 k59_341240_1 765911.Thivi_3067 1.75e-84 269.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1WWM9@135613|Chromatiales 135613|Chromatiales O Cytochrome c-type biogenesis protein - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_994182_1 1123326.JFBL01000018_gene2339 9.36e-58 190.0 COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2YRCR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_667732_1 702450.CUW_0827 1.35e-44 164.0 COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,3VP8D@526524|Erysipelotrichia 526524|Erysipelotrichia J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_634653_1 765913.ThidrDRAFT_0180 4.56e-137 400.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales 135613|Chromatiales U Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_634653_2 1121459.AQXE01000002_gene1245 2.9e-36 142.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S7S@68525|delta/epsilon subdivisions,2WNFR@28221|Deltaproteobacteria,2M9XW@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GAF_2,GGDEF,PAS,PAS_3,PAS_4 k59_634653_4 1049564.TevJSym_at00700 0.0 1288.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1J4YE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_634653_6 1049564.TevJSym_at00740 1.24e-93 277.0 COG0622@1|root,COG0622@2|Bacteria,1RCUQ@1224|Proteobacteria,1S2YE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_929729_1 326298.Suden_0910 4.82e-100 319.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2YMA1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_307086_1 1096930.L284_08615 9.11e-45 167.0 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_929734_1 1122194.AUHU01000003_gene1978 2.66e-22 97.8 2CKCQ@1|root,31FHN@2|Bacteria,1RKED@1224|Proteobacteria,1SKDY@1236|Gammaproteobacteria,46A4R@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_145754_1 1415779.JOMH01000001_gene1263 1.06e-49 168.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1X3EY@135614|Xanthomonadales 135614|Xanthomonadales M Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_210627_1 187272.Mlg_0661 2.64e-10 58.5 COG2905@1|root,COG2905@2|Bacteria,1RI05@1224|Proteobacteria,1S7Q3@1236|Gammaproteobacteria,1WZSY@135613|Chromatiales 135613|Chromatiales T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_210627_2 1255043.TVNIR_1863 2.31e-36 127.0 COG0347@1|root,COG0347@2|Bacteria,1NEHV@1224|Proteobacteria,1S7AN@1236|Gammaproteobacteria,1WZH3@135613|Chromatiales 135613|Chromatiales E Belongs to the P(II) protein family - - - - - - - - - - - - - k59_210627_3 387093.SUN_1865 3.72e-73 235.0 arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,42P6Y@68525|delta/epsilon subdivisions,2YMZI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_863016_1 1123399.AQVE01000027_gene30 2.96e-42 150.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,460AB@72273|Thiotrichales 72273|Thiotrichales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_863016_2 765912.Thimo_0725 2.2e-70 224.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales 135613|Chromatiales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_79125_1 869213.JCM21142_104067 1.99e-133 413.0 COG0553@1|root,COG1203@1|root,COG0553@2|Bacteria,COG1203@2|Bacteria 2|Bacteria L DNA/RNA hybrid annealing activity - - 3.6.4.12 ko:K03657,ko:K07012 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03400 - - - AAA_34,Helicase_C,Helicase_C_4,ResIII,UvrD-helicase,UvrD_C_2 k59_210628_1 1122225.AULQ01000001_gene1793 1.11e-35 124.0 2CJFR@1|root,32T3P@2|Bacteria,4NTID@976|Bacteroidetes,1I41R@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_210628_2 1120951.AUBG01000017_gene3301 9.04e-11 59.7 COG2318@1|root,COG2318@2|Bacteria,4NQBY@976|Bacteroidetes,1I30V@117743|Flavobacteriia 976|Bacteroidetes S Damage-inducible protein DinB - - - - - - - - - - - - DinB_2 k59_863018_1 745014.OMB55_00023250 4.84e-30 121.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU type I secretion outer membrane protein, TolC tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_373487_1 1168034.FH5T_00410 1.08e-105 312.0 COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,2FWQX@200643|Bacteroidia 976|Bacteroidetes S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_668509_1 1049564.TevJSym_aa00800 1.21e-50 171.0 COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,1J6DZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters bioH GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:0090499,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - iBWG_1329.BWG_3103,iECBD_1354.ECBD_0333,iECDH10B_1368.ECDH10B_3587,iECDH1ME8569_1439.ECDH1ME8569_3291,iETEC_1333.ETEC_3662,iEcDH1_1363.EcDH1_0301,iJO1366.b3412,iY75_1357.Y75_RS20155 Abhydrolase_1,Abhydrolase_6 k59_830868_1 1333998.M2A_1287 2.16e-23 100.0 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,4BS2P@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q MlaD protein MA20_08125 - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_145762_1 515635.Dtur_0873 7.24e-98 317.0 COG2804@1|root,COG2804@2|Bacteria 2|Bacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_731829_1 536227.CcarbDRAFT_3853 2.86e-25 101.0 COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,36E1V@31979|Clostridiaceae 186801|Clostridia S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_437867_1 1120946.AUBF01000012_gene1237 5.93e-42 157.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4D311@85005|Actinomycetales 201174|Actinobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_242372_1 768671.ThimaDRAFT_1325 4.67e-66 216.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria,1X080@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_602864_1 572544.Ilyop_0298 2.46e-34 121.0 COG3630@1|root,COG3630@2|Bacteria 2|Bacteria C sodium ion export across plasma membrane oadG GO:0003674,GO:0003824,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008948,GO:0015672,GO:0016829,GO:0016830,GO:0016831,GO:0030001,GO:0051179,GO:0051234 4.1.1.3 ko:K01573 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_gamma k59_602864_2 572544.Ilyop_0297 1.46e-10 60.8 COG3051@1|root,COG3051@2|Bacteria,379CJ@32066|Fusobacteria 32066|Fusobacteria C Citrate lyase, alpha subunit (CitF) citF - 2.8.3.10 ko:K01643 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - CitF k59_765309_1 526218.Sterm_2707 5.88e-18 82.4 COG0061@1|root,COG0061@2|Bacteria,37A1D@32066|Fusobacteria 32066|Fusobacteria H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_765309_2 572544.Ilyop_1478 4.56e-154 454.0 COG0497@1|root,COG0497@2|Bacteria,378SP@32066|Fusobacteria 32066|Fusobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_437884_1 979556.MTES_3156 7.3e-12 65.1 COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4FKI1@85023|Microbacteriaceae 201174|Actinobacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase k59_437884_2 743718.Isova_1025 2.08e-39 134.0 COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4F4UA@85017|Promicromonosporaceae 201174|Actinobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_668541_1 1121101.HMPREF1532_02078 2.56e-46 163.0 COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,2FMMZ@200643|Bacteroidia,4ATQR@815|Bacteroidaceae 976|Bacteroidetes G Converts alpha-aldose to the beta-anomer - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_373519_1 1249627.D779_2785 4.48e-22 100.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales 135613|Chromatiales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_635446_1 472759.Nhal_2027 5.46e-30 117.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,1RS1G@1236|Gammaproteobacteria,1WXVJ@135613|Chromatiales 135613|Chromatiales C TIGRFAM SagB-type dehydrogenase domain - - - - - - - - - - - - Nitroreductase k59_635446_2 1297742.A176_05914 2.68e-07 53.9 COG0741@1|root,COG0741@2|Bacteria 2|Bacteria M lytic transglycosylase activity - - - - - - - - - - - - SLT k59_961687_1 4155.Migut.D01426.1.p 1.69e-59 187.0 COG0522@1|root,KOG3301@2759|Eukaryota,37TGK@33090|Viridiplantae,3G7BN@35493|Streptophyta,44PVZ@71274|asterids 35493|Streptophyta J Ribosomal protein S4/S9 N-terminal domain rps4 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_44731_1 1121940.AUDZ01000017_gene2456 3.3e-59 186.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XJH4@135619|Oceanospirillales 135619|Oceanospirillales K at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA) glnK-2 - - ko:K04752 - - - - ko00000 - - - P-II k59_342036_1 1121935.AQXX01000131_gene2773 3.65e-20 91.7 COG1073@1|root,COG1073@2|Bacteria,1MZUA@1224|Proteobacteria,1S9ZY@1236|Gammaproteobacteria,1XM1G@135619|Oceanospirillales 135619|Oceanospirillales S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 k59_795035_1 1121904.ARBP01000004_gene988 1.09e-109 335.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_830916_1 1120970.AUBZ01000003_gene75 1.4e-23 93.2 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,468EX@72275|Alteromonadaceae 1236|Gammaproteobacteria S DUF167 yggU - - ko:K09131 - - - - ko00000 - - - DUF167 k59_273797_1 880072.Desac_1996 5.07e-39 134.0 COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,42VFB@68525|delta/epsilon subdivisions,2WRRQ@28221|Deltaproteobacteria,2MRRH@213462|Syntrophobacterales 28221|Deltaproteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_273797_2 543913.D521_1509 1.87e-16 79.0 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2VQQ0@28216|Betaproteobacteria,1KQSM@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_312284_1 1049564.TevJSym_be00160 3.8e-19 87.4 COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,1T2GY@1236|Gammaproteobacteria,1J6IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M TonB C terminal tolA - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2,TonB_C k59_216055_1 929558.SMGD1_1085 3.09e-95 290.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2YMQ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_737447_2 1121403.AUCV01000014_gene4632 2.32e-106 314.0 COG0535@1|root,COG0535@2|Bacteria,1R6IV@1224|Proteobacteria,42YE7@68525|delta/epsilon subdivisions,2WU7H@28221|Deltaproteobacteria,2MMU0@213118|Desulfobacterales 28221|Deltaproteobacteria S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12 k59_248304_1 1541959.KQ51_00538 1.4e-42 152.0 COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria 2|Bacteria U 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - DUF362,Fer4,Fer4_10,Fer4_7 k59_312861_1 913865.DOT_5120 3.32e-116 341.0 COG0376@1|root,COG0376@2|Bacteria,1TQDA@1239|Firmicutes,24DM7@186801|Clostridia,260RF@186807|Peptococcaceae 186801|Clostridia P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_800602_1 1268068.PG5_60520 1.04e-05 47.0 COG0622@1|root,COG0622@2|Bacteria,1N8BH@1224|Proteobacteria 1224|Proteobacteria S Phosphoesterase - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_800602_2 1537917.JU82_06840 1.19e-41 154.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2YMH2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_868959_1 1168034.FH5T_04905 7.01e-75 234.0 COG5653@1|root,COG5653@2|Bacteria,4NQN5@976|Bacteroidetes,2FT4P@200643|Bacteroidia 976|Bacteroidetes M Protein involved in cellulose biosynthesis - - - - - - - - - - - - Acetyltransf_6 k59_543311_1 1247649.D560_2579 6.74e-125 364.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,3T1H4@506|Alcaligenaceae 28216|Betaproteobacteria C NADPH quinone reductase and related Zn-dependent oxidoreductases qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_706167_1 1165841.SULAR_00275 3.91e-109 321.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2YMHA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_379269_1 387093.SUN_0228 1.08e-107 330.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2YMS1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhF - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_312873_1 709032.Sulku_1578 4.77e-98 296.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2YN18@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_312873_2 1537917.JU82_04480 7.08e-198 556.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2YMJQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.92 ko:K15895 ko00520,map00520 - R09825 RC00006,RC00781 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 k59_312873_3 929558.SMGD1_0161 1.16e-06 48.9 COG0171@1|root,COG0171@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2YNG2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase k59_248310_2 1121129.KB903367_gene2630 6.33e-84 263.0 COG0527@1|root,COG0527@2|Bacteria,4NFWR@976|Bacteroidetes,2FMTV@200643|Bacteroidia,22X04@171551|Porphyromonadaceae 976|Bacteroidetes E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_935207_2 985762.SAGN_10660 2.73e-11 64.7 COG0511@1|root,COG0511@2|Bacteria,1VAB7@1239|Firmicutes,4HKCS@91061|Bacilli,4GZ3T@90964|Staphylococcaceae 91061|Bacilli I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_935207_3 572544.Ilyop_1470 2.21e-70 225.0 COG0439@1|root,COG0439@2|Bacteria,379P7@32066|Fusobacteria 32066|Fusobacteria I acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_50435_1 1123393.KB891316_gene1736 3.94e-109 346.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KSFJ@119069|Hydrogenophilales 119069|Hydrogenophilales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_800625_1 1234364.AMSF01000055_gene1089 1.77e-68 214.0 COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria,1X3BY@135614|Xanthomonadales 135614|Xanthomonadales K Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_800632_1 326298.Suden_0566 2.1e-70 233.0 COG1256@1|root,COG1749@1|root,COG1256@2|Bacteria,COG1749@2|Bacteria,1MV2M@1224|Proteobacteria,42PBN@68525|delta/epsilon subdivisions,2YMGR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_379302_1 90814.KL370891_gene1865 7.22e-25 105.0 2DR8A@1|root,33AMX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_511373_1 1304885.AUEY01000036_gene2266 4.06e-63 216.0 COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,42NF1@68525|delta/epsilon subdivisions,2WK52@28221|Deltaproteobacteria,2MI9T@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the heat shock protein 70 family - - - - - - - - - - - - DUF3731,HSP70 k59_1000682_1 998674.ATTE01000001_gene1102 3.74e-60 201.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,461YX@72273|Thiotrichales 72273|Thiotrichales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_216691_1 1165841.SULAR_10684 4.58e-98 297.0 COG3245@1|root,COG3258@1|root,COG3245@2|Bacteria,COG3258@2|Bacteria,1QTYW@1224|Proteobacteria,42WAQ@68525|delta/epsilon subdivisions,2YTG9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrome_CBB3 k59_543357_2 1249480.B649_05840 2.57e-30 117.0 COG2885@1|root,COG2885@2|Bacteria,1MZKA@1224|Proteobacteria,42U2D@68525|delta/epsilon subdivisions,2YQ5B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_543357_3 1123326.JFBL01000001_gene1392 1.43e-30 114.0 COG4254@1|root,COG4254@2|Bacteria,1N739@1224|Proteobacteria,42VBI@68525|delta/epsilon subdivisions,2YQ2P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S FecR protein - - - - - - - - - - - - FecR k59_543357_4 1172190.M947_06730 1.54e-30 115.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,42RGS@68525|delta/epsilon subdivisions,2YNY5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N k59_1032265_1 1121013.P873_12175 1.15e-75 243.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1X3IH@135614|Xanthomonadales 135614|Xanthomonadales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_935234_1 709032.Sulku_0337 9.77e-111 340.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2YMPF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_902111_1 1260251.SPISAL_00265 1.02e-44 150.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales 135613|Chromatiales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_902111_2 472759.Nhal_3812 4.81e-88 281.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_800643_1 717606.PaecuDRAFT_3963 1.17e-52 187.0 COG0204@1|root,COG0764@1|root,COG3321@1|root,COG0204@2|Bacteria,COG0764@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins - - - - - - - - - - - - AMP-binding,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_836750_1 1168034.FH5T_20925 7.83e-43 144.0 COG1225@1|root,COG1225@2|Bacteria,4NMEK@976|Bacteroidetes,2G13J@200643|Bacteroidia 976|Bacteroidetes O Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin k59_1032276_1 1123267.JONN01000002_gene21 1.63e-64 218.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,2K0DV@204457|Sphingomonadales 204457|Sphingomonadales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_771357_1 1121403.AUCV01000013_gene4008 7.74e-107 329.0 COG5492@1|root,COG5492@2|Bacteria,1QY8X@1224|Proteobacteria,43CAR@68525|delta/epsilon subdivisions,2X7M8@28221|Deltaproteobacteria 28221|Deltaproteobacteria C domain, Protein - - - - - - - - - - - - - k59_476771_1 177437.HRM2_46340 3.22e-41 138.0 COG0358@1|root,COG0358@2|Bacteria,1N8NW@1224|Proteobacteria,42WR7@68525|delta/epsilon subdivisions,2WS70@28221|Deltaproteobacteria,2MP12@213118|Desulfobacterales 28221|Deltaproteobacteria L Zinc finger, CHC2-type protein - - - - - - - - - - - - zf-CHC2 k59_869016_1 743299.Acife_1499 1.5e-180 513.0 COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RR5N@1236|Gammaproteobacteria,2NDPF@225057|Acidithiobacillales 225057|Acidithiobacillales S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_869016_2 1283300.ATXB01000002_gene2968 1.35e-26 99.8 COG1396@1|root,COG1396@2|Bacteria,1NGQR@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - ko:K15773 - - - - ko00000,ko02048,ko03000 - - - HTH_3,HTH_31 k59_869016_3 667632.KB890182_gene877 3.79e-54 174.0 COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,2VUGN@28216|Betaproteobacteria,1K7AT@119060|Burkholderiaceae 28216|Betaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - ko:K07062 - - - - ko00000,ko01000,ko02048 - - - PIN k59_869016_4 314278.NB231_13701 8.1e-26 98.2 COG4691@1|root,COG4691@2|Bacteria,1NAMF@1224|Proteobacteria,1SD4G@1236|Gammaproteobacteria,1X1U3@135613|Chromatiales 135613|Chromatiales S Plasmid stability protein - - - - - - - - - - - - - k59_869016_5 1331060.RLDS_17950 6e-31 116.0 COG5340@1|root,COG5340@2|Bacteria,1RGNP@1224|Proteobacteria,2U1VQ@28211|Alphaproteobacteria,2K8M3@204457|Sphingomonadales 28211|Alphaproteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_543363_1 1460635.JCM19038_287 2.81e-27 109.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli 91061|Bacilli D recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_50463_1 484018.BACPLE_01706 3.53e-24 107.0 COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,2FM0P@200643|Bacteroidia,4AKYP@815|Bacteroidaceae 976|Bacteroidetes G beta-galactosidase - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_935259_1 1123020.AUIE01000005_gene4286 1.37e-40 148.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1YE4H@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Acetyl-coenzyme A synthetase N-terminus acsA - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_935259_2 1123519.PSJM300_09340 6.03e-11 65.1 COG1485@1|root,COG1485@2|Bacteria,1MWH4@1224|Proteobacteria,1RMXV@1236|Gammaproteobacteria,1Z03Q@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S AFG1-like ATPase - - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_411608_1 1437824.BN940_11346 8.18e-38 141.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,3T2IU@506|Alcaligenaceae 28216|Betaproteobacteria I Fatty acid desaturase ole1 - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_184155_1 519989.ECTPHS_08211 4.51e-39 137.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,1WXXM@135613|Chromatiales 135613|Chromatiales S HAD-superfamily hydrolase, subfamily IA, variant 1 - - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_184155_2 1123514.KB905899_gene1023 5.47e-20 88.2 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,460FS@72273|Thiotrichales 72273|Thiotrichales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_737521_1 1537917.JU82_11050 1.69e-22 96.3 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2YMP0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H arginine decarboxylase speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0422 Orn_Arg_deC_N k59_737521_2 1537917.JU82_11055 4.7e-216 604.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2YMII@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_706223_1 1168034.FH5T_05950 8.41e-82 265.0 COG2366@1|root,COG2366@2|Bacteria,4NEIX@976|Bacteroidetes 976|Bacteroidetes S PFAM peptidase S45 penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_443756_1 448385.sce4818 7.22e-48 160.0 COG1028@1|root,COG1028@2|Bacteria,1MW4W@1224|Proteobacteria,43E25@68525|delta/epsilon subdivisions,2WZH0@28221|Deltaproteobacteria,2Z24S@29|Myxococcales 28221|Deltaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_641372_1 1168034.FH5T_01610 3.97e-76 239.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FMPG@200643|Bacteroidia 976|Bacteroidetes T acetoacetate metabolism regulatory protein AtoC K07714 - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_641372_2 1168034.FH5T_01615 1.2e-46 164.0 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,2FR1C@200643|Bacteroidia 976|Bacteroidetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_800673_1 863365.XHC_4424 6.47e-17 79.0 COG1595@1|root,COG1595@2|Bacteria,1N6SV@1224|Proteobacteria,1S570@1236|Gammaproteobacteria,1X6UZ@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_771377_1 1307761.L21SP2_2583 1.67e-25 104.0 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity nodI - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran k59_771377_2 889378.Spiaf_2383 2.27e-108 322.0 COG0842@1|root,COG0842@2|Bacteria 2|Bacteria V Transport permease protein nodJ - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane k59_771377_3 1211817.CCAT010000012_gene2837 2.06e-48 163.0 COG1971@1|root,COG1971@2|Bacteria,1V4QK@1239|Firmicutes,24FY0@186801|Clostridia,36ICE@31979|Clostridiaceae 186801|Clostridia P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp k59_312929_1 1283300.ATXB01000001_gene1395 2.64e-115 337.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1XDVR@135618|Methylococcales 135618|Methylococcales I Enoyl- acyl-carrier-protein reductase NADH fabI - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_312930_1 522306.CAP2UW1_1025 7.9e-142 410.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,1KQGY@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Cys/Met metabolism PLP-dependent enzyme metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_902125_1 1168034.FH5T_19725 3.26e-72 223.0 COG0084@1|root,COG0084@2|Bacteria,4NSGW@976|Bacteroidetes,2FQ90@200643|Bacteroidia 976|Bacteroidetes L hydrolase, TatD family - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_902125_2 1168034.FH5T_19720 8.26e-72 221.0 COG1179@1|root,COG1179@2|Bacteria,4NEKB@976|Bacteroidetes,2FMG4@200643|Bacteroidia 976|Bacteroidetes H ThiF family hypB - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_706237_1 313625.BL107_06159 5.49e-50 175.0 COG0463@1|root,COG0463@2|Bacteria,1GMYZ@1117|Cyanobacteria,1H00Z@1129|Synechococcus 1117|Cyanobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_543377_1 411902.CLOBOL_07079 1.4e-151 449.0 COG2211@1|root,COG2211@2|Bacteria,1TSEH@1239|Firmicutes,25MPI@186801|Clostridia,21YWX@1506553|Lachnoclostridium 186801|Clostridia G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_216727_1 1419583.V466_19425 4.45e-11 68.6 COG0642@1|root,COG0834@1|root,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RQCU@1236|Gammaproteobacteria,1YUPN@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T Histidine Phosphotransfer domain evgS GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0009927,GO:0009987,GO:0010447,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07677,ko:K07679 ko02020,ko02026,ko05133,map02020,map02026,map05133 M00474,M00477 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg,SBP_bac_3 k59_800687_1 1095769.CAHF01000005_gene1570 4.09e-56 186.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,476ER@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_869044_1 749222.Nitsa_0640 7.06e-44 151.0 COG0470@1|root,COG0470@2|Bacteria,1R9U1@1224|Proteobacteria,42R45@68525|delta/epsilon subdivisions,2YPZZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_869044_2 387093.SUN_0459 1.41e-11 64.7 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2YMDM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H dihydropteroate synthase folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_248403_1 1537917.JU82_03860 2.91e-59 189.0 COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,42N60@68525|delta/epsilon subdivisions,2YMCU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S phosphoribosyltransferase - - - ko:K07100 - - - - ko00000 - - - Pribosyltran k59_347944_1 1049564.TevJSym_ac01950 4.86e-190 536.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1J4M5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_836778_2 1537917.JU82_09865 5.81e-59 190.0 COG0470@1|root,COG0470@2|Bacteria,1R9U1@1224|Proteobacteria,42R45@68525|delta/epsilon subdivisions,2YPZZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_575798_1 700598.Niako_3599 7.88e-46 160.0 COG0329@1|root,COG0329@2|Bacteria,4NFIH@976|Bacteroidetes,1IQG0@117747|Sphingobacteriia 976|Bacteroidetes H Belongs to the DapA family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_575798_2 1187851.A33M_0718 9.4e-19 88.2 COG1995@1|root,COG3395@1|root,COG1995@2|Bacteria,COG3395@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,3FCZ3@34008|Rhodovulum 28211|Alphaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_50497_1 572544.Ilyop_1533 8.36e-112 335.0 COG1207@1|root,COG1207@2|Bacteria,378XH@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3,NTP_transferase k59_575800_1 31964.CMS1687 8.77e-06 52.4 COG1073@1|root,COG1073@2|Bacteria,2GNDJ@201174|Actinobacteria 201174|Actinobacteria Q Belongs to the glycosyl hydrolase family 6 - - 3.1.1.101 ko:K21104 - - R11540 - ko00000,ko01000 - - - Abhydrolase_5,CBM_2,DLH,Hydrolase_4,PAF-AH_p_II,Ricin_B_lectin k59_641378_1 1005048.CFU_0629 5.84e-168 508.0 COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,472JM@75682|Oxalobacteraceae 28216|Betaproteobacteria C Domain of unknown function (DUF3400) glpCD - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_543394_1 1168034.FH5T_12410 5.79e-124 366.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,2FPY6@200643|Bacteroidia 976|Bacteroidetes I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - - - - - - - - - - - Carboxyl_trans k59_50498_1 1121396.KB893079_gene852 4.75e-135 397.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2MIFG@213118|Desulfobacterales 28221|Deltaproteobacteria P Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_280209_1 395493.BegalDRAFT_1564 6.15e-24 101.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales 72273|Thiotrichales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_280209_2 243265.plu3972 4.16e-14 76.6 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca GO:0001680,GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016437,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042245,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_801442_1 1033810.HLPCO_002736 1.66e-39 143.0 COG2984@1|root,COG2984@2|Bacteria,2NPCT@2323|unclassified Bacteria 2|Bacteria S ABC transporter substrate binding protein - - - ko:K01989,ko:K05832 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind,BPD_transp_2 k59_642111_1 1168034.FH5T_04320 6.07e-34 123.0 COG0545@1|root,COG0545@2|Bacteria,4NDW4@976|Bacteroidetes,2G31Y@200643|Bacteroidia 976|Bacteroidetes M Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_612630_2 929558.SMGD1_2784 7.54e-75 226.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42PGH@68525|delta/epsilon subdivisions,2YN8W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Molybdenum cofactor biosynthesis protein mogA - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_18427_1 1123393.KB891326_gene87 1.37e-09 58.5 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2VKCX@28216|Betaproteobacteria 28216|Betaproteobacteria G Phosphoglucomutase phosphomannomutase alpha beta alpha domain I pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1004623_1 944480.ATUV01000001_gene1400 2.24e-44 162.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2M722@213113|Desulfurellales 28221|Deltaproteobacteria J tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_187965_1 1218074.BAXZ01000015_gene3172 2.5e-53 181.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2VSDG@28216|Betaproteobacteria,1KGMN@119060|Burkholderiaceae 28216|Betaproteobacteria I Alpha beta hydrolase - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_612642_1 999550.KI421507_gene2653 1.04e-125 360.0 COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VEY7@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0437 Fe-S-cluster-containing hydrogenase components 1 fdhB - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4,Fer4_11,Fer4_7 k59_612642_2 1123400.KB904768_gene3408 4.71e-25 102.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales 72273|Thiotrichales C Molybdopterin oxidoreductase Fe4S4 domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_220472_1 667632.KB890217_gene4738 5.12e-20 91.3 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria,1K0KN@119060|Burkholderiaceae 28216|Betaproteobacteria S Competence protein comF - - - - - - - - - - - Pribosyltran k59_220472_2 338963.Pcar_1390 1.05e-55 187.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,43T6E@69541|Desulfuromonadales 28221|Deltaproteobacteria P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_515464_1 1220535.IMCC14465_07910 4.39e-18 89.4 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2U059@28211|Alphaproteobacteria,4BRVA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Cysteine-rich domain - - 1.1.5.3 ko:K00113 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - CCG k59_741447_1 1124983.PFLCHA0_c60030 7.12e-36 139.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1YNG5@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_804536_1 1123276.KB893264_gene4611 1.62e-12 68.9 COG2159@1|root,COG2159@2|Bacteria,4NK6T@976|Bacteroidetes,47MSC@768503|Cytophagia 976|Bacteroidetes S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_283337_1 246195.DNO_0181 2.46e-143 438.0 COG1474@1|root,COG1474@2|Bacteria,1R5I2@1224|Proteobacteria,1RXXF@1236|Gammaproteobacteria 1236|Gammaproteobacteria LO Belongs to the peptidase S16 family - - - - - - - - - - - - - k59_515473_1 1270196.JCKI01000005_gene3145 2.23e-07 51.2 COG0854@1|root,COG0854@2|Bacteria,4NF4Z@976|Bacteroidetes,1IQ0U@117747|Sphingobacteriia 976|Bacteroidetes H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_515473_2 1168034.FH5T_21965 2.23e-70 218.0 COG0596@1|root,COG0596@2|Bacteria,4NDZI@976|Bacteroidetes,2FTEM@200643|Bacteroidia 976|Bacteroidetes S Serine aminopeptidase, S33 ybfF - - - - - - - - - - - Abhydrolase_1 k59_155452_1 1304885.AUEY01000050_gene1198 9.43e-148 431.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WJVC@28221|Deltaproteobacteria,2MINJ@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_316739_1 1040986.ATYO01000008_gene2672 1.75e-51 179.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,43IID@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_612657_1 880073.Calab_2935 7.81e-65 214.0 COG3005@1|root,COG3005@2|Bacteria,2NQ9M@2323|unclassified Bacteria 2|Bacteria C NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - - - - - - - - - - Cytochrom_NNT,Cytochrom_c3_2 k59_351676_2 1123401.JHYQ01000001_gene1824 6.51e-23 89.7 COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,1SESI@1236|Gammaproteobacteria,463D1@72273|Thiotrichales 72273|Thiotrichales S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_187975_1 393921.HQ45_04035 2.64e-84 261.0 COG2262@1|root,COG2262@2|Bacteria,4NF0P@976|Bacteroidetes,2FM9T@200643|Bacteroidia,22W7M@171551|Porphyromonadaceae 976|Bacteroidetes S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_872795_1 323848.Nmul_A0467 5.41e-83 262.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2VKCX@28216|Betaproteobacteria,3722M@32003|Nitrosomonadales 28216|Betaproteobacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_447623_1 511062.GU3_09530 2.4e-43 144.0 COG3223@1|root,COG3223@2|Bacteria,1N0MS@1224|Proteobacteria,1S9SN@1236|Gammaproteobacteria,1Y5WJ@135624|Aeromonadales 135624|Aeromonadales S Phosphate-starvation-inducible E - - - ko:K13256 - - - - ko00000 - - - PsiE k59_840559_1 1121012.AUKX01000003_gene1519 2.07e-11 70.9 COG0702@1|root,COG0702@2|Bacteria,4NEDB@976|Bacteroidetes,1IFV8@117743|Flavobacteriia,23IBC@178469|Arenibacter 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_515478_1 1165841.SULAR_01455 1.74e-137 405.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1R5RS@1224|Proteobacteria,42M3K@68525|delta/epsilon subdivisions,2YN6E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM biotin lipoyl attachment domain-containing protein pycB - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_447638_1 1168034.FH5T_10395 1.11e-155 444.0 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,2FQSG@200643|Bacteroidia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23,OEP k59_515481_3 572544.Ilyop_1313 2.06e-150 438.0 COG1132@1|root,COG1132@2|Bacteria,378QA@32066|Fusobacteria 32066|Fusobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_383050_1 563040.Saut_1743 3.5e-126 364.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2YMWV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_840573_1 675817.VDA_002940 3.92e-61 211.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XSHU@135623|Vibrionales 135623|Vibrionales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019752,GO:0031323,GO:0033238,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1035824_1 1123256.KB907950_gene3190 3.39e-06 48.1 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RS3E@1236|Gammaproteobacteria,1X5AU@135614|Xanthomonadales 135614|Xanthomonadales S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_1035824_2 1117647.M5M_09607 1.14e-131 387.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,1J4W6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O metalloendopeptidase pepO - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_187999_1 1123326.JFBL01000001_gene1276 3.76e-109 320.0 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,42Z77@68525|delta/epsilon subdivisions,2YRAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_187999_2 1123326.JFBL01000001_gene1277 5.95e-07 49.3 COG2077@1|root,COG2077@2|Bacteria,1Q5Y2@1224|Proteobacteria,4321Y@68525|delta/epsilon subdivisions,2YS92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides - - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - - k59_872814_1 572544.Ilyop_0563 3.83e-144 418.0 COG0147@1|root,COG0147@2|Bacteria,378IB@32066|Fusobacteria 32066|Fusobacteria EH Psort location Cytoplasmic, score pabB - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind,GATase k59_804577_1 156889.Mmc1_2139 2.56e-95 287.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component dctP - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_612701_1 765912.Thimo_1294 9.09e-114 344.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1WW58@135613|Chromatiales 135613|Chromatiales S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_775273_1 768671.ThimaDRAFT_2617 4.04e-99 295.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales 135613|Chromatiales KO TIGRFAM Hydrogenase accessory protein HypB - - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_415290_1 1322246.BN4_10956 2.37e-25 108.0 COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria,2MH87@213115|Desulfovibrionales 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_515507_2 1121875.KB907551_gene1007 7.18e-40 146.0 COG1468@1|root,COG1468@2|Bacteria,4PM88@976|Bacteroidetes,1IJMB@117743|Flavobacteriia 976|Bacteroidetes L Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_121990_1 870187.Thini_0278 5.76e-54 183.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,4637B@72273|Thiotrichales 72273|Thiotrichales C Fe-S oxidoreductase - - - - - - - - - - - - CCG,Fer4_8 k59_121990_2 1417296.U879_20705 2.93e-73 228.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,2UIT4@28211|Alphaproteobacteria 28211|Alphaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_155495_1 1298867.AUES01000051_gene4504 7.13e-110 334.0 COG0653@1|root,COG0653@2|Bacteria,1MX0P@1224|Proteobacteria,2U086@28211|Alphaproteobacteria,3K2HA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria U SecA preprotein cross-linking domain - - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind k59_804592_1 439235.Dalk_3007 2.79e-71 230.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2MMYN@213118|Desulfobacterales 28221|Deltaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_351720_1 880070.Cycma_3815 5.19e-104 316.0 COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,47MQK@768503|Cytophagia 976|Bacteroidetes P Arylsulfatase A - - - - - - - - - - - - DUF4976,Sulfatase k59_678465_1 1249480.B649_06270 5.28e-121 371.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2YMV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_906200_1 381666.H16_A3424 7.79e-44 154.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,1K1I1@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM VacJ family lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_972144_1 326298.Suden_1813 8.23e-60 200.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2YQN3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_972144_2 1304883.KI912532_gene1960 1.65e-29 114.0 2DB6R@1|root,2Z7I2@2|Bacteria,1R7AG@1224|Proteobacteria,2VQZS@28216|Betaproteobacteria,2KYBI@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1036700_1 1236542.BALM01000031_gene1900 9.56e-38 140.0 COG0303@1|root,COG1763@1|root,COG0303@2|Bacteria,COG1763@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,2Q981@267890|Shewanellaceae 1236|Gammaproteobacteria H MoeA domain protein domain I and II moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MobB,MoeA_C,MoeA_N k59_1036700_2 1537915.JU57_02815 2.79e-28 110.0 COG2221@1|root,COG2221@2|Bacteria,1QUIJ@1224|Proteobacteria,43BJ1@68525|delta/epsilon subdivisions,2YT8Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrite and sulphite reductase 4Fe-4S napF - - ko:K02572 - - - - ko00000 - - - Fer4 k59_1036700_3 929558.SMGD1_0592 7.74e-18 84.3 COG3043@1|root,COG3043@2|Bacteria,1NAZB@1224|Proteobacteria,42SN1@68525|delta/epsilon subdivisions,2YPF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Electron transfer subunit of the periplasmic nitrate reductase complex NapAB napB - - ko:K02568 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798 RC02812 ko00000,ko00001,ko00002 - - - NapB k59_1036700_4 713587.THITH_07505 3.98e-38 137.0 COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,1RQ1I@1236|Gammaproteobacteria,1X08E@135613|Chromatiales 135613|Chromatiales C 4Fe-4S binding domain - - - ko:K02574 - - - - ko00000 - - - Fer4_5 k59_448521_1 85643.Tmz1t_2951 1.86e-77 242.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2VV78@28216|Betaproteobacteria,2KXPH@206389|Rhodocyclales 206389|Rhodocyclales E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_448521_2 648757.Rvan_0036 1.54e-05 46.2 COG1024@1|root,COG1024@2|Bacteria,1R8QP@1224|Proteobacteria,2UNSE@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.100 ko:K07537 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05597 RC03168 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_873464_1 1168034.FH5T_03150 2.72e-54 182.0 COG0285@1|root,COG0285@2|Bacteria,4NES8@976|Bacteroidetes,2FNFB@200643|Bacteroidia 976|Bacteroidetes H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_221057_1 1249480.B649_00455 3.11e-152 439.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2YMNB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_19086_1 550540.Fbal_0665 1.48e-09 63.9 COG1404@1|root,COG1404@2|Bacteria,1MVJE@1224|Proteobacteria,1RQ2M@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Inhibitor_I9,PA,PPC,Peptidase_S8 k59_679141_1 929703.KE386491_gene2099 2.39e-42 159.0 COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes,47MS0@768503|Cytophagia 976|Bacteroidetes V Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_188690_1 641147.HMPREF9021_01408 1.18e-21 87.4 COG1977@1|root,COG1977@2|Bacteria,1NAHE@1224|Proteobacteria,2WB4X@28216|Betaproteobacteria,2KRUH@206351|Neisseriales 206351|Neisseriales H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_188690_2 1234364.AMSF01000015_gene3109 9.69e-53 182.0 COG0314@1|root,COG0476@1|root,COG0314@2|Bacteria,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1X3YQ@135614|Xanthomonadales 135614|Xanthomonadales H ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase moeB - - - - - - - - - - - Rhodanese,ThiF k59_188690_3 1101192.KB910516_gene3118 1.22e-68 220.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,1JSTB@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_352347_1 396588.Tgr7_2929 1.01e-12 65.1 COG0727@1|root,COG0727@2|Bacteria,1NXZE@1224|Proteobacteria,1SQVM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_352347_2 177437.HRM2_07850 3.03e-37 130.0 COG0655@1|root,COG0655@2|Bacteria,1RAK6@1224|Proteobacteria,42QS5@68525|delta/epsilon subdivisions,2WN2M@28221|Deltaproteobacteria,2MIU5@213118|Desulfobacterales 28221|Deltaproteobacteria S Flavodoxin-like fold - - - - - - - - - - - - FMN_red k59_448534_1 1537917.JU82_00930 8.68e-73 224.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2YMCQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_448534_2 1537917.JU82_00935 2.38e-27 100.0 COG1758@1|root,COG1758@2|Bacteria,1Q28G@1224|Proteobacteria,42V5Z@68525|delta/epsilon subdivisions,2YQDH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_679154_1 1318628.MARLIPOL_15879 3.94e-26 101.0 2C945@1|root,32W5M@2|Bacteria,1RFGX@1224|Proteobacteria 1224|Proteobacteria - - - - 5.4.4.1 ko:K01865 ko00627,ko01120,map00627,map01120 - - - ko00000,ko00001,ko01000 - - - - k59_54873_1 3067.XP_002954608.1 1.82e-07 58.5 KOG0274@1|root,KOG0274@2759|Eukaryota,37V1D@33090|Viridiplantae,34I44@3041|Chlorophyta 3041|Chlorophyta S WD domain, G-beta repeat - - - - - - - - - - - - WD40 k59_122588_1 1249627.D779_1100 4.2e-57 189.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1WX7X@135613|Chromatiales 135613|Chromatiales J SAM-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_122588_2 768671.ThimaDRAFT_2221 1.46e-24 97.1 COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1WY57@135613|Chromatiales 135613|Chromatiales O OsmC-like protein - - - - - - - - - - - - OsmC k59_283985_1 1249480.B649_09680 1.52e-52 174.0 COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions,2YNGT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Hydrogenase-4, component G - - - ko:K14090 - - - - ko00000 - - - Complex1_49kDa,NiFeSe_Hases k59_448547_1 177437.HRM2_40960 1.27e-47 159.0 COG0526@1|root,COG0526@2|Bacteria,1QWP1@1224|Proteobacteria,43BTZ@68525|delta/epsilon subdivisions,2X74Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria CO AhpC/TSA family - - - - - - - - - - - - AhpC-TSA k59_1036730_2 105559.Nwat_0645 7.76e-68 213.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales 135613|Chromatiales O TIGRFAM FeS assembly ATPase SufC - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_221081_1 338966.Ppro_3460 1.39e-31 127.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,43AN8@68525|delta/epsilon subdivisions,2X62F@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - BTAD k59_646009_1 610130.Closa_1434 5.61e-59 201.0 COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,21XVZ@1506553|Lachnoclostridium 186801|Clostridia G Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_548001_1 232346.JHQL01000004_gene1772 2.94e-66 209.0 COG0221@1|root,COG0221@2|Bacteria,1RF8Z@1224|Proteobacteria,1S4VZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Inorganic pyrophosphatase - - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_89764_1 1408473.JHXO01000006_gene1255 4.84e-96 312.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,2FNH9@200643|Bacteroidia 976|Bacteroidetes E Glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_805256_1 944546.ABED_2015 1.07e-101 303.0 COG2842@1|root,COG2842@2|Bacteria,1PSN7@1224|Proteobacteria,42SI9@68525|delta/epsilon subdivisions,2YRDF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Bacterial TniB protein - - - - - - - - - - - - TniB k59_805256_2 944546.ABED_2016 8.05e-66 213.0 2DKIW@1|root,309MK@2|Bacteria,1RF7C@1224|Proteobacteria,42T89@68525|delta/epsilon subdivisions,2YR98@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TniQ - - - - - - - - - - - - TniQ k59_972178_1 1249480.B649_08215 1.86e-52 171.0 COG1739@1|root,COG1739@2|Bacteria,1NFJC@1224|Proteobacteria,42T7W@68525|delta/epsilon subdivisions,2YPM6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S hmm pf01205 - - - - - - - - - - - - DUF1949,UPF0029 k59_287467_2 469616.FMAG_01576 1.07e-130 375.0 COG0336@1|root,COG0336@2|Bacteria,378KH@32066|Fusobacteria 32066|Fusobacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_287467_3 696369.KI912183_gene2624 8.47e-31 114.0 COG1661@1|root,COG1661@2|Bacteria,1VBWE@1239|Firmicutes,24HQ2@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - ko:K06934 - - - - ko00000 - - - DUF296 k59_943042_2 83406.HDN1F_01990 5.07e-31 114.0 COG3436@1|root,COG3436@2|Bacteria,1N638@1224|Proteobacteria,1SFHC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L IS66 Orf2 like protein - - - - - - - - - - - - TnpB_IS66 k59_583652_1 1449068.JMLQ01000001_gene43 2.87e-09 62.4 COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,2GJJ9@201174|Actinobacteria,4FYH1@85025|Nocardiaceae 201174|Actinobacteria P Binding-protein-dependent transport system inner membrane component tcyA/tcyB - - ko:K02029,ko:K02424,ko:K10009 ko02010,map02010 M00234,M00236 - - ko00000,ko00001,ko00002,ko02000,ko02035 3.A.1.3,3.A.1.3.10,3.A.1.3.14 - - BPD_transp_1,SBP_bac_3 k59_744952_1 1122599.AUGR01000004_gene2205 5.87e-70 217.0 COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,1RM8J@1236|Gammaproteobacteria,1XNJ0@135619|Oceanospirillales 135619|Oceanospirillales L 3' exoribonuclease, RNase T-like - - - - - - - - - - - - RNase_T k59_191883_1 450851.PHZ_c0425 9.63e-50 170.0 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2KFEX@204458|Caulobacterales 204458|Caulobacterales E Hydroxymethylglutaryl-CoA lyase - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_92927_1 631454.N177_2252 2.41e-55 198.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,1JMZJ@119043|Rhodobiaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase MA20_18100 - 3.1.4.52 ko:K13245 ko04112,map04112 - R08991 RC00296 ko00000,ko00001,ko01000 - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_3 k59_974901_1 187272.Mlg_2438 4.77e-74 231.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales 135613|Chromatiales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_974901_2 105559.Nwat_0986 1.38e-29 113.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1WWVF@135613|Chromatiales 135613|Chromatiales S Competence protein - - - - - - - - - - - - Pribosyltran k59_909492_1 290397.Adeh_1659 2.42e-68 223.0 COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - - - - - - - - - - Cytochrom_NNT k59_224262_1 1172190.M947_01800 5.32e-38 139.0 COG1538@1|root,COG1538@2|Bacteria,1Q066@1224|Proteobacteria,42RNJ@68525|delta/epsilon subdivisions,2YNZR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_452390_1 1128427.KB904821_gene1482 7.78e-35 128.0 28IMV@1|root,2Z8NA@2|Bacteria,1GBNW@1117|Cyanobacteria,1HEKI@1150|Oscillatoriales 1117|Cyanobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_843957_2 670487.Ocepr_0084 4.86e-55 190.0 COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus 2|Bacteria C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate - - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_779087_1 1548151.LS70_01090 1.07e-58 197.0 2AHY8@1|root,318BB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_779087_2 1485545.JQLW01000009_gene167 7.12e-87 261.0 COG5340@1|root,COG5340@2|Bacteria,1R1GM@1224|Proteobacteria 1224|Proteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - AbiEi_4 k59_779087_3 944547.ABLL_0883 6.03e-144 416.0 COG2253@1|root,COG2253@2|Bacteria,1PZRM@1224|Proteobacteria,42SAJ@68525|delta/epsilon subdivisions 1224|Proteobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_519623_1 1168034.FH5T_14660 2.03e-131 385.0 COG1215@1|root,COG1215@2|Bacteria,4NMSY@976|Bacteroidetes,2FSAI@200643|Bacteroidia 976|Bacteroidetes M Pfam Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_125960_1 1454004.AW11_00566 1.53e-117 341.0 COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria 1224|Proteobacteria P Phosphate transport regulator (Distant homolog of PhoU) UF78_21250 - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_191899_1 1265505.ATUG01000003_gene325 3.29e-47 161.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,42STV@68525|delta/epsilon subdivisions,2WKKA@28221|Deltaproteobacteria,2MJB6@213118|Desulfobacterales 28221|Deltaproteobacteria O Tellurite resistance protein TerB - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_519626_1 439497.RR11_1289 6.52e-09 58.5 COG2172@1|root,COG2172@2|Bacteria,1N7CT@1224|Proteobacteria,2UFUR@28211|Alphaproteobacteria,4NCDK@97050|Ruegeria 28211|Alphaproteobacteria T Histidine kinase-like ATPase domain rsbW - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 k59_160087_2 1121935.AQXX01000093_gene3413 9.18e-71 222.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1XHPG@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the RimK family rimK - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_552364_1 944547.ABLL_1446 2.48e-52 185.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria 1224|Proteobacteria P Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_256615_1 86416.Clopa_0640 8.23e-87 289.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,36DIR@31979|Clostridiaceae 1239|Firmicutes G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_256615_2 1163617.SCD_n00189 5.21e-57 202.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria 28216|Betaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_649551_1 879212.DespoDRAFT_01525 2.51e-141 415.0 COG3829@1|root,COG3829@2|Bacteria,1N1WB@1224|Proteobacteria,42P76@68525|delta/epsilon subdivisions,2WIU6@28221|Deltaproteobacteria,2MIIW@213118|Desulfobacterales 28221|Deltaproteobacteria KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat k59_160613_1 1537917.JU82_08455 3.68e-52 178.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42NDE@68525|delta/epsilon subdivisions,2YMNM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Hydrogenase, large subunit hupL - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_160613_2 387092.NIS_0963 1.25e-94 288.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2YMAS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Small subunit hydA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.5.1 ko:K05927 - - - - ko00000,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_877165_1 377629.TERTU_2321 1.07e-26 116.0 COG2755@1|root,COG2755@2|Bacteria,1N3FB@1224|Proteobacteria,1RW9E@1236|Gammaproteobacteria,2PPTD@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - CBM_6,Lipase_GDSL_2 k59_23082_1 273121.WS1156 9.79e-46 159.0 COG2014@1|root,COG2014@2|Bacteria,1R8SV@1224|Proteobacteria,42YF4@68525|delta/epsilon subdivisions,2YRIQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative heavy-metal chelation - - - ko:K09138 - - - - ko00000 - - - DUF364 k59_779696_2 757424.Hsero_2055 1.01e-08 58.2 COG2882@1|root,COG2882@2|Bacteria,1N4IX@1224|Proteobacteria,2VUIK@28216|Betaproteobacteria,47909@75682|Oxalobacteraceae 28216|Betaproteobacteria N flagellar fliJ - - ko:K02413 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliJ k59_779696_3 1049564.TevJSym_ac00730 9.98e-113 338.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,1RM9W@1236|Gammaproteobacteria,1J55H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_714440_1 933262.AXAM01000004_gene2368 3.75e-42 144.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,42WB9@68525|delta/epsilon subdivisions,2WQ0S@28221|Deltaproteobacteria,2MKS1@213118|Desulfobacterales 28221|Deltaproteobacteria S PHB/PHA accumulation regulator DNA-binding domain - - - - - - - - - - - - PHB_acc_N k59_714441_1 1123253.AUBD01000004_gene1063 1.51e-37 141.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X41A@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_714441_2 1122194.AUHU01000013_gene731 4.55e-58 193.0 COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,469FI@72275|Alteromonadaceae 1236|Gammaproteobacteria S Pyridine nucleotide-disulphide oxidoreductase sqr - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_126235_1 515622.bpr_I2391 5.27e-28 112.0 COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,4BWE0@830|Butyrivibrio 186801|Clostridia E Aminotransferase class I and II hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_126235_3 333138.LQ50_03435 2.75e-23 96.7 COG4989@1|root,COG4989@2|Bacteria,1TQ12@1239|Firmicutes,4HA57@91061|Bacilli,1ZD8D@1386|Bacillus 91061|Bacilli S Oxidoreductase ycsN - - - - - - - - - - - Aldo_ket_red k59_484441_2 926559.JoomaDRAFT_0289 3.36e-26 107.0 COG0246@1|root,COG0246@2|Bacteria,4NEMT@976|Bacteroidetes,1I085@117743|Flavobacteriia 976|Bacteroidetes G PFAM Mannitol dehydrogenase C-terminal domain uxaB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009026,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.1.1.17,1.1.1.58 ko:K00009,ko:K00041 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00631 R02555,R02703 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_975482_1 1121405.dsmv_2657 1.71e-66 212.0 COG1092@1|root,COG1092@2|Bacteria,1QW1V@1224|Proteobacteria,42Q3P@68525|delta/epsilon subdivisions,2WJXM@28221|Deltaproteobacteria,2MHVR@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the methyltransferase superfamily - - 2.1.1.173,2.1.1.191,2.1.1.264 ko:K06969,ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_484451_1 545276.KB898734_gene2333 3.77e-19 85.9 COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,1X01T@135613|Chromatiales 135613|Chromatiales HJ TIGRFAM alpha-L-glutamate ligase-like protein - - - - - - - - - - - - ATPgrasp_ST k59_975485_1 879212.DespoDRAFT_03282 1.13e-107 323.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,42M5T@68525|delta/epsilon subdivisions,2WJF2@28221|Deltaproteobacteria,2MHSA@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the NifD NifK NifE NifN family nifE - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_419374_1 1249480.B649_11475 4.72e-15 77.0 COG3177@1|root,COG3177@2|Bacteria,1NB0K@1224|Proteobacteria,42QY1@68525|delta/epsilon subdivisions,2YRJN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Fic/DOC family - - - - - - - - - - - - Fic k59_484457_1 1537917.JU82_03325 1.98e-96 296.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2YMWR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_93456_2 1027273.GZ77_12535 7.89e-18 84.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1XM0V@135619|Oceanospirillales 135619|Oceanospirillales D cell division protein - - - - - - - - - - - - SPOR k59_388686_1 243231.GSU2792 1.35e-26 106.0 COG0500@1|root,COG0500@2|Bacteria,1QW0F@1224|Proteobacteria,43C56@68525|delta/epsilon subdivisions,2X7FJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_356023_1 572477.Alvin_2082 1.56e-06 49.3 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1WW2D@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_779725_1 1232410.KI421414_gene2922 8.98e-80 256.0 COG2766@1|root,COG2766@2|Bacteria,1PXNG@1224|Proteobacteria,42N5G@68525|delta/epsilon subdivisions,2WINM@28221|Deltaproteobacteria,43S13@69541|Desulfuromonadales 28221|Deltaproteobacteria T PrkA AAA domain prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_714464_1 1151116.Q7S_19415 1.93e-11 63.9 COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,1RN1W@1236|Gammaproteobacteria,3FF3M@34037|Rahnella 1236|Gammaproteobacteria N Protein of unknown function (DUF2950) - - - - - - - - - - - - DUF2950 k59_256682_1 574966.KB898650_gene389 5.37e-44 148.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1XJXJ@135619|Oceanospirillales 135619|Oceanospirillales I Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc k59_256682_2 519989.ECTPHS_06922 9.4e-47 154.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1WX50@135613|Chromatiales 135613|Chromatiales O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_23118_1 1168034.FH5T_21900 1.41e-46 157.0 COG1208@1|root,COG1208@2|Bacteria,4PKJR@976|Bacteroidetes,2G07F@200643|Bacteroidia 976|Bacteroidetes JM COG NOG09722 non supervised orthologous group - - - - - - - - - - - - NTP_transferase k59_23118_2 1168034.FH5T_21905 1.29e-23 98.2 COG2334@1|root,COG2334@2|Bacteria,4NH00@976|Bacteroidetes,2FKYD@200643|Bacteroidia 976|Bacteroidetes S mucin-desulfating sulfatase mdsC - - - - - - - - - - - APH k59_975501_1 449447.MAE_60010 8.35e-44 166.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria 1117|Cyanobacteria Q Amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_25,PP-binding,Thioesterase k59_745556_1 272952.HpaP811239 1.29e-22 101.0 COG0105@1|root,KOG0888@2759|Eukaryota,3QA8H@4776|Peronosporales 4776|Peronosporales F NDK - - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_745556_3 398512.JQKC01000023_gene3289 5.34e-105 329.0 COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,3WHA0@541000|Ruminococcaceae 186801|Clostridia J Metallo-beta-lactamase domain protein - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL k59_584383_1 1336233.JAEH01000004_gene1598 8.17e-39 144.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,2QA7M@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM MscS Mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_649590_2 1033802.SSPSH_000424 4.32e-35 140.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0729 Outer membrane protein tamA - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_745557_2 1396858.Q666_02140 6.37e-53 172.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,4677Y@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the CinA family ygaD GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_388715_1 1279038.KB907337_gene283 1.85e-18 78.2 COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,2UJAW@28211|Alphaproteobacteria,2JUIS@204441|Rhodospirillales 204441|Rhodospirillales P Heavy-metal-associated domain - - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA k59_256701_1 1168034.FH5T_17615 1.67e-105 317.0 28H5M@1|root,2Z7I7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_552447_1 1116472.MGMO_43c00040 3.32e-35 126.0 COG0637@1|root,COG0637@2|Bacteria,1QTT8@1224|Proteobacteria,1T1GC@1236|Gammaproteobacteria,1XE2I@135618|Methylococcales 135618|Methylococcales S PFAM Haloacid dehalogenase-like hydrolase - - 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_714476_1 742727.HMPREF9447_02592 1e-101 325.0 COG2273@1|root,COG3533@1|root,COG2273@2|Bacteria,COG3533@2|Bacteria,4PNXU@976|Bacteroidetes,2FRD1@200643|Bacteroidia 976|Bacteroidetes G Ricin-type beta-trefoil lectin domain-like - - - - - - - - - - - - Laminin_G_3,RicinB_lectin_2 k59_356045_1 1168289.AJKI01000023_gene1928 3.2e-157 456.0 COG3344@1|root,COG3344@2|Bacteria,4NGGU@976|Bacteroidetes,2FWED@200643|Bacteroidia,3XKBZ@558415|Marinilabiliaceae 976|Bacteroidetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,HNH,RVT_1,RVT_N k59_1008801_1 1537917.JU82_03770 6.14e-69 262.0 COG1195@1|root,COG5295@1|root,COG1195@2|Bacteria,COG5295@2|Bacteria,1R0Y3@1224|Proteobacteria,42NCY@68525|delta/epsilon subdivisions,2YN22@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Hep Hag repeat protein - - - - - - - - - - - - - k59_453339_1 1304284.L21TH_1970 2.54e-79 243.0 COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,36DMA@31979|Clostridiaceae 186801|Clostridia E Glutamate formiminotransferase ftcD - 2.1.2.5 ko:K00603 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R03189 RC00165,RC00221,RC00223,RC00870 ko00000,ko00001,ko01000 - - - FTCD,FTCD_N k59_453339_2 742767.HMPREF9456_00141 2.43e-07 51.6 COG1228@1|root,COG1228@2|Bacteria,4NE6C@976|Bacteroidetes,2FNW2@200643|Bacteroidia,22W99@171551|Porphyromonadaceae 976|Bacteroidetes Q Imidazolone-5-propionate hydrolase hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_456028_1 522306.CAP2UW1_2481 2.37e-23 100.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2VKJT@28216|Betaproteobacteria 28216|Betaproteobacteria C Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k59_456028_2 990073.ATHU01000001_gene1786 7.14e-09 56.6 COG0454@1|root,COG4886@1|root,COG0456@2|Bacteria,COG4886@2|Bacteria,1Q94S@1224|Proteobacteria,42X59@68525|delta/epsilon subdivisions,2YQUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KLT COG4886 Leucine-rich repeat (LRR) protein - - - - - - - - - - - - LRR_4,LRR_8,Pkinase k59_195140_1 204669.Acid345_4692 1.22e-10 65.5 COG0739@1|root,COG0739@2|Bacteria,3Y3N4@57723|Acidobacteria,2JHPR@204432|Acidobacteriia 204432|Acidobacteriia M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_227947_1 1268239.PALB_27860 4.84e-74 239.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,2Q0MW@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Glutamate carboxypeptidase II - - - - - - - - - - - - PA,Peptidase_M28 k59_1043917_1 349741.Amuc_0772 1.01e-87 276.0 COG0588@1|root,COG1052@1|root,COG0588@2|Bacteria,COG1052@2|Bacteria,46SGM@74201|Verrucomicrobia,2ITY0@203494|Verrucomicrobiae 203494|Verrucomicrobiae CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_422218_1 1121129.KB903374_gene579 1.67e-44 155.0 COG0598@1|root,COG0598@2|Bacteria,4NG3C@976|Bacteroidetes,2FPIV@200643|Bacteroidia,22XS7@171551|Porphyromonadaceae 976|Bacteroidetes P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_61933_1 1379270.AUXF01000005_gene642 1.21e-27 117.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_685979_1 997296.PB1_17553 1.71e-22 100.0 COG5527@1|root,COG5527@2|Bacteria,1V1XJ@1239|Firmicutes,4HGH6@91061|Bacilli,1ZI53@1386|Bacillus 91061|Bacilli L Initiator Replication protein - - - - - - - - - - - - L_lactis_RepB_C,Rep_3 k59_555502_1 1408442.JADE01000009_gene461 1.91e-80 257.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2YMD3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_555502_3 1121344.JHZO01000004_gene1736 8.35e-35 127.0 COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,3WIS5@541000|Ruminococcaceae 186801|Clostridia L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_323464_6 1262449.CP6013_2683 3.8e-08 60.8 COG0500@1|root,COG2226@2|Bacteria,1U5XV@1239|Firmicutes,24A44@186801|Clostridia,36HFC@31979|Clostridiaceae 186801|Clostridia Q Methyltransferase arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_323464_7 742818.HMPREF9451_01639 5.18e-246 714.0 COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4CU8E@84998|Coriobacteriia 84998|Coriobacteriia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_129453_1 396588.Tgr7_2114 4.23e-35 137.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_129453_2 331869.BAL199_14347 1.63e-28 109.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2TS0J@28211|Alphaproteobacteria,4BPZJ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q ABC transporter ybbA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_290671_1 479431.Namu_1304 4.6e-67 218.0 COG1760@1|root,COG1760@2|Bacteria,2GJPA@201174|Actinobacteria,4ERPV@85013|Frankiales 201174|Actinobacteria E PFAM serine dehydratase alpha chain sdaA GO:0003674,GO:0003824,GO:0003941,GO:0016829,GO:0016840,GO:0016841 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_422232_1 644282.Deba_1809 2.28e-98 299.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKE@68525|delta/epsilon subdivisions,2WJTK@28221|Deltaproteobacteria 28221|Deltaproteobacteria MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_748298_1 1168034.FH5T_10550 2.8e-36 128.0 COG0546@1|root,COG0546@2|Bacteria,4NMPP@976|Bacteroidetes,2FS95@200643|Bacteroidia 976|Bacteroidetes S HAD hydrolase, family IA, variant - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_748298_2 1168034.FH5T_10545 5.48e-57 193.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,4NECB@976|Bacteroidetes,2FNV6@200643|Bacteroidia 976|Bacteroidetes J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_323480_1 156889.Mmc1_3745 2.28e-54 175.0 COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,2U6FZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_456645_1 1249480.B649_05365 8.88e-78 254.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2YMSQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II k59_717301_1 497964.CfE428DRAFT_3886 3.63e-67 216.0 COG4124@1|root,COG4124@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 26 family - - - - - - - - - - - - Glyco_hydro_26 k59_259562_1 1121015.N789_02170 4.33e-87 268.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RR6H@1236|Gammaproteobacteria,1X5MV@135614|Xanthomonadales 135614|Xanthomonadales C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN k59_652274_1 999411.HMPREF1092_01365 4.78e-16 82.0 COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,249P0@186801|Clostridia,36HE3@31979|Clostridiaceae 186801|Clostridia S PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_195848_1 644282.Deba_2013 5.98e-64 216.0 COG0745@1|root,COG2203@1|root,COG2206@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria 28221|Deltaproteobacteria T metal-dependent phosphohydrolase HD region - - - - - - - - - - - - GAF_2,GAF_3,GGDEF,HD,Response_reg k59_290675_1 572544.Ilyop_1472 0.0 1010.0 COG0587@1|root,COG0587@2|Bacteria,378JD@32066|Fusobacteria 32066|Fusobacteria L DNA polymerase III - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_96162_1 1385420.FRA_71c15850 4.34e-23 104.0 COG5527@1|root,COG5527@2|Bacteria,1R7A6@1224|Proteobacteria,1RQMU@1236|Gammaproteobacteria,462Z3@72273|Thiotrichales 72273|Thiotrichales L COGs COG5527 Protein involved in initiation of plasmid replication - - - - - - - - - - - - Rep_3 k59_946800_2 435832.HMPREF0604_01456 1.67e-14 78.2 COG2270@1|root,COG2270@2|Bacteria,1QUVA@1224|Proteobacteria,2WHTQ@28216|Betaproteobacteria,2KU4X@206351|Neisseriales 206351|Neisseriales S AmpG muropeptide MFS transporter K08218 - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_978675_1 1121405.dsmv_0948 4.99e-62 214.0 COG0764@1|root,COG3321@1|root,COG0764@2|Bacteria,COG3321@2|Bacteria,1QUWM@1224|Proteobacteria,43BRB@68525|delta/epsilon subdivisions,2WJJ6@28221|Deltaproteobacteria,2MI1Q@213118|Desulfobacterales 28221|Deltaproteobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family - - - - - - - - - - - - Acyl_transf_1,Acyltransferase,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt k59_717321_1 33876.JNXY01000020_gene4320 1.38e-16 81.3 COG0637@1|root,COG0637@2|Bacteria,2IQD3@201174|Actinobacteria,4DI2I@85008|Micromonosporales 201174|Actinobacteria S haloacid dehalogenase-like hydrolase - - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_748310_1 572544.Ilyop_1336 2.51e-192 550.0 COG1032@1|root,COG1032@2|Bacteria,378ZU@32066|Fusobacteria 32066|Fusobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_748310_2 1408439.JHXW01000003_gene1645 1.48e-82 256.0 COG1559@1|root,COG1559@2|Bacteria,378DS@32066|Fusobacteria 32066|Fusobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_1011697_1 1168034.FH5T_20555 3.52e-123 376.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,4NFTI@976|Bacteroidetes,2FNSJ@200643|Bacteroidia 976|Bacteroidetes C CoA binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_652286_1 688246.Premu_0714 2.93e-06 51.6 COG4584@1|root,COG4584@2|Bacteria,4NEY6@976|Bacteroidetes,2FMHY@200643|Bacteroidia 976|Bacteroidetes L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - GerE,HTH_23,HTH_7,rve k59_391867_1 1517682.HW49_00570 2.64e-43 154.0 COG1866@1|root,COG1866@2|Bacteria,4NEGI@976|Bacteroidetes,2FNYK@200643|Bacteroidia,22VYR@171551|Porphyromonadaceae 976|Bacteroidetes H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_61979_1 713587.THITH_02125 2.88e-52 181.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - DUF3306,Fer4,Fer4_10,Fer4_6,Fer4_7 k59_228028_1 526218.Sterm_3675 4.98e-96 290.0 COG0796@1|root,COG0796@2|Bacteria,379AN@32066|Fusobacteria 32066|Fusobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_228028_2 1319815.HMPREF0202_02033 5.13e-65 206.0 COG0632@1|root,COG0632@2|Bacteria,379WA@32066|Fusobacteria 32066|Fusobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_228028_3 572544.Ilyop_1837 1.18e-10 62.0 COG2165@1|root,COG2165@2|Bacteria 2|Bacteria NU general secretion pathway protein - - - ko:K02246,ko:K02247,ko:K02456,ko:K02457,ko:K02458,ko:K10924 ko03070,ko05111,map03070,map05111 M00331,M00429 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,SBP_bac_10 k59_555548_1 1123236.KB899396_gene3358 4.67e-23 102.0 COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,1RN0A@1236|Gammaproteobacteria,469EF@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1043969_1 572544.Ilyop_0228 8.64e-70 221.0 COG0502@1|root,COG0502@2|Bacteria,379PA@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_1011706_1 1049564.TevJSym_bl00210 2.33e-32 120.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1J4T1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_1011706_2 998674.ATTE01000001_gene3696 4.45e-34 129.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,45ZXP@72273|Thiotrichales 72273|Thiotrichales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_228035_1 396588.Tgr7_2629 5.17e-80 248.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1WX3R@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_228035_2 1123393.KB891316_gene1321 2.93e-07 52.4 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,2VS39@28216|Betaproteobacteria,1KSUU@119069|Hydrogenophilales 119069|Hydrogenophilales C FMN_bind - - - - - - - - - - - - FMN_bind k59_913066_1 1168034.FH5T_16335 3.53e-81 244.0 COG0655@1|root,COG0655@2|Bacteria,4NIVA@976|Bacteroidetes,2FP5V@200643|Bacteroidia 976|Bacteroidetes S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_913066_2 1168034.FH5T_22110 1.85e-65 213.0 COG0205@1|root,COG0205@2|Bacteria,4NIKT@976|Bacteroidetes,2FNYX@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_129513_1 1122614.JHZF01000015_gene2390 5.01e-05 47.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,2PCK9@252301|Oceanicola 28211|Alphaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_652310_1 1168034.FH5T_04825 6.8e-116 345.0 COG0606@1|root,COG0606@2|Bacteria,4NE0G@976|Bacteroidetes,2FMHE@200643|Bacteroidia 976|Bacteroidetes O Mg chelatase-like protein comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_620265_2 639030.JHVA01000001_gene3873 1.55e-23 95.1 COG0622@1|root,COG0622@2|Bacteria,3Y51P@57723|Acidobacteria,2JJEG@204432|Acidobacteriia 204432|Acidobacteriia S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_456695_1 177437.HRM2_39510 9.59e-12 65.9 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42SM4@68525|delta/epsilon subdivisions,2WPVD@28221|Deltaproteobacteria,2MNUX@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_456695_2 485915.Dret_1500 2.07e-34 126.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NG2@68525|delta/epsilon subdivisions,2WK33@28221|Deltaproteobacteria,2MGH2@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_323503_1 1132855.KB913035_gene1758 2.22e-46 153.0 COG3439@1|root,COG3439@2|Bacteria,1RHJQ@1224|Proteobacteria,2W3X3@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_323503_2 743721.Psesu_2703 1.2e-63 202.0 COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria,1X3SS@135614|Xanthomonadales 135614|Xanthomonadales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_195852_1 768671.ThimaDRAFT_3865 3.95e-314 868.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_195852_2 768671.ThimaDRAFT_3864 1.71e-81 244.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,1WXGS@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, small subunit - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_195852_3 1049564.TevJSym_af00550 6.16e-205 571.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1J4GH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iJN746.PP_4678,iLF82_1304.LF82_1103 IlvC,IlvN k59_195852_4 983545.Glaag_3060 2.76e-102 305.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,4645F@72275|Alteromonadaceae 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_195852_5 1049564.TevJSym_am00790 3.12e-297 820.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1J4FM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0066 HMGL-like,LeuA_dimer k59_195852_6 1049564.TevJSym_am00800 1.6e-90 275.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L TIGRFAM Phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_422294_2 313589.JNB_06799 5e-99 304.0 COG0033@1|root,COG0033@2|Bacteria,2H1PI@201174|Actinobacteria,4FFBE@85021|Intrasporangiaceae 201174|Actinobacteria G Phosphoglucomutase pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_290734_1 311403.Arad_9823 6.35e-56 176.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBQE@28211|Alphaproteobacteria,4BFDC@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_290734_2 1317124.DW2_08457 4.55e-34 123.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2XNQZ@285107|Thioclava 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve k59_717385_1 794846.AJQU01000157_gene4277 5.12e-24 107.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,2UEEB@28211|Alphaproteobacteria,4BAW0@82115|Rhizobiaceae 28211|Alphaproteobacteria L High confidence in function and specificity - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_391907_1 1713.JOFV01000005_gene2133 5.11e-99 295.0 COG0175@1|root,COG0175@2|Bacteria,2GJ3Z@201174|Actinobacteria,4F0TA@85016|Cellulomonadaceae 201174|Actinobacteria EH Belongs to the PAPS reductase family. CysH subfamily cysH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004604,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016667,GO:0016671,GO:0019344,GO:0019752,GO:0040007,GO:0043436,GO:0043866,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2392 PAPS_reduct k59_358887_1 349520.PPE_01933 2.48e-13 73.2 COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,4H9ZW@91061|Bacilli,26S55@186822|Paenibacillaceae 91061|Bacilli S DHH family nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_358887_2 1172190.M947_09880 9.3e-09 55.1 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,42MY7@68525|delta/epsilon subdivisions,2YMP6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_290738_1 469618.FVAG_00610 3.02e-77 241.0 COG0673@1|root,COG0673@2|Bacteria,378VU@32066|Fusobacteria 32066|Fusobacteria S domain protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_422307_1 28229.ND2E_1403 5.91e-119 345.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) phbB - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_978748_1 1121405.dsmv_1692 1.98e-41 155.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42NTQ@68525|delta/epsilon subdivisions,2WITY@28221|Deltaproteobacteria,2MIFP@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM peptidase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_880143_1 439235.Dalk_4040 8.9e-34 127.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42S94@68525|delta/epsilon subdivisions,2WNCW@28221|Deltaproteobacteria,2MNBQ@213118|Desulfobacterales 1224|Proteobacteria C Cysteine-rich domain - - - - - - - - - - - - CCG,Fer4_8 k59_880143_2 903818.KI912269_gene285 2.93e-39 143.0 COG0277@1|root,COG0277@2|Bacteria 2|Bacteria C FAD linked oxidase domain protein - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - BBE,FAD_binding_4 k59_847607_1 1245469.S58_37940 4.71e-33 119.0 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2VGD2@28211|Alphaproteobacteria,3JYBS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_847607_2 1248916.ANFY01000003_gene787 1.23e-46 155.0 COG0346@1|root,COG0346@2|Bacteria,1RK3P@1224|Proteobacteria,2UANZ@28211|Alphaproteobacteria,2K5JM@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_812146_1 243231.GSU2832 1.03e-12 65.5 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,43U5H@69541|Desulfuromonadales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_812146_2 1121405.dsmv_3564 5.87e-90 273.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MI89@213118|Desulfobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_978756_1 452637.Oter_0944 8.06e-30 110.0 COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia,3K87F@414999|Opitutae 414999|Opitutae S RNA recognition motif - - - - - - - - - - - - RRM_1 k59_458281_2 35703.DQ02_04270 1.27e-09 66.2 COG2207@1|root,COG2207@2|Bacteria,1Q3UX@1224|Proteobacteria,1RS88@1236|Gammaproteobacteria,3WVRA@544|Citrobacter 1236|Gammaproteobacteria K helix_turn_helix, arabinose operon control protein - - - ko:K04033 - - - - ko00000,ko03000 - - - HTH_18 k59_490850_1 526218.Sterm_2269 1.03e-28 114.0 COG0165@1|root,COG0165@2|Bacteria,378W4@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_490850_2 1128398.Curi_c06880 2.41e-27 108.0 COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,26889@186813|unclassified Clostridiales 186801|Clostridia E Arginosuccinate synthase argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_441_1 105559.Nwat_2894 2e-126 400.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg k59_883212_1 1319815.HMPREF0202_01116 7.45e-128 382.0 COG0534@1|root,COG0534@2|Bacteria,379HS@32066|Fusobacteria 32066|Fusobacteria V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE k59_523622_1 1001585.MDS_2815 8.84e-71 228.0 COG3385@1|root,COG3385@2|Bacteria,1PQZT@1224|Proteobacteria,1TBQQ@1236|Gammaproteobacteria,1YIJZ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_948532_1 1485544.JQKP01000011_gene711 1.18e-53 177.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2VHPX@28216|Betaproteobacteria,44VPD@713636|Nitrosomonadales 28216|Betaproteobacteria N PFAM MotA TolQ ExbB proton channel motA - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_654420_1 1173025.GEI7407_0864 2.89e-59 194.0 COG0123@1|root,COG0123@2|Bacteria,1G1JN@1117|Cyanobacteria,1H8NM@1150|Oscillatoriales 1117|Cyanobacteria BQ including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl k59_915908_1 762376.AXYL_03196 1.01e-11 68.9 COG4623@1|root,COG4623@2|Bacteria 2|Bacteria M carbon-oxygen lyase activity, acting on polysaccharides VP0557 - - - - - - - - - - - SBP_bac_3,SLT k59_915908_2 439235.Dalk_0152 8.07e-08 53.5 COG0730@1|root,COG0730@2|Bacteria,1P10Q@1224|Proteobacteria 1224|Proteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_556324_1 880073.Calab_2683 7.17e-43 156.0 COG1007@1|root,COG1007@2|Bacteria,2NNMY@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_719759_1 1469245.JFBG01000059_gene2424 3.7e-49 172.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales 135613|Chromatiales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_589069_1 105559.Nwat_2060 6.01e-29 114.0 COG2982@1|root,COG2982@2|Bacteria,1N0N6@1224|Proteobacteria,1SF4A@1236|Gammaproteobacteria,1X1M1@135613|Chromatiales 135613|Chromatiales M Protein involved in outer membrane biogenesis - - - - - - - - - - - - - k59_817788_1 391038.Bphy_0318 2.93e-06 56.2 COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,1K1RH@119060|Burkholderiaceae 28216|Betaproteobacteria O TPR repeat-containing protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_490868_1 626939.HMPREF9443_02074 1.1e-10 60.5 COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,4H25R@909932|Negativicutes 909932|Negativicutes E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_490868_2 550540.Fbal_1709 1.26e-52 172.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria 1236|Gammaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_2372,iPC815.YPO1545,iYL1228.KPN_02479 GATase k59_65964_1 1249627.D779_2923 7.06e-114 333.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_327607_1 390989.JOEG01000004_gene3809 4.51e-07 60.5 COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4D8N4@85008|Micromonosporales 201174|Actinobacteria L Participates in initiation and elongation during chromosome replication dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_65965_1 1165841.SULAR_05363 9.44e-82 254.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2YMAU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_785100_1 755732.Fluta_4073 3.83e-28 113.0 COG1672@1|root,COG1672@2|Bacteria,4NGM3@976|Bacteroidetes,1I7BN@117743|Flavobacteriia 976|Bacteroidetes S ATPase (AAA superfamily) - - - ko:K06921 - - - - ko00000 - - - ATPase_2 k59_785100_2 1168034.FH5T_06670 7.62e-16 74.3 COG2122@1|root,COG2122@2|Bacteria,4NME4@976|Bacteroidetes,2FS5D@200643|Bacteroidia 976|Bacteroidetes S PFAM ApbE family - - - ko:K09740 - - - - ko00000 - - - - k59_915927_1 1355368.JART01000036_gene1797 1.22e-72 231.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,42RYH@68525|delta/epsilon subdivisions,2YTS7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_360253_1 1283300.ATXB01000001_gene477 1.5e-108 323.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1XG18@135618|Methylococcales 135618|Methylococcales I Transposase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_687121_1 768671.ThimaDRAFT_2445 1.12e-68 233.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_360254_1 944547.ABLL_2110 8.16e-59 190.0 COG2346@1|root,COG2346@2|Bacteria,1N1UU@1224|Proteobacteria,43B84@68525|delta/epsilon subdivisions,2YRXC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_229497_1 177439.DP0005 5.42e-34 123.0 COG0106@1|root,COG0106@2|Bacteria,1R6J2@1224|Proteobacteria,43B0N@68525|delta/epsilon subdivisions,2X6EQ@28221|Deltaproteobacteria,2MICV@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the HisA HisF family - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_33351_1 1121396.KB893094_gene4441 1.36e-75 248.0 COG0531@1|root,COG0531@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease,SLC12 k59_556348_1 1121011.AUCB01000018_gene4107 6.6e-95 302.0 COG1434@1|root,COG1470@1|root,COG1434@2|Bacteria,COG1470@2|Bacteria,4NE96@976|Bacteroidetes,1HYC3@117743|Flavobacteriia,23FP2@178469|Arenibacter 976|Bacteroidetes G beta-galactosidase activity - - - - - - - - - - - - NPCBM k59_490880_1 387093.SUN_1729 1.54e-75 227.0 COG1943@1|root,COG1943@2|Bacteria,1RF1K@1224|Proteobacteria,42VRT@68525|delta/epsilon subdivisions,2YQZ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COGs COG1943 Transposase and inactivated derivatives - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_981248_1 387093.SUN_2273 2.24e-46 157.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42PA1@68525|delta/epsilon subdivisions,2YNMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_621739_1 391596.PBAL39_14144 6.19e-23 97.8 COG1595@1|root,COG1595@2|Bacteria,4NVCP@976|Bacteroidetes,1ISUP@117747|Sphingobacteriia 976|Bacteroidetes K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog - - - - - - - - - - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_360260_1 702450.CUW_1208 5.54e-96 294.0 COG1609@1|root,COG1609@2|Bacteria,1TSIJ@1239|Firmicutes,3VNXV@526524|Erysipelotrichia 526524|Erysipelotrichia K helix_turn _helix lactose operon repressor - - - - - - - - - - - - LacI,Peripla_BP_3 k59_480_1 323848.Nmul_A1749 1.76e-15 77.8 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,3720B@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the peptidase S1C family degQ - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_458306_1 526218.Sterm_2105 1.95e-71 232.0 COG2759@1|root,COG2759@2|Bacteria,37930@32066|Fusobacteria 32066|Fusobacteria H Formyltetrahydrofolate synthetase fhs GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_458306_2 469616.FMAG_01460 0.0 1789.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,378KP@32066|Fusobacteria 32066|Fusobacteria F Psort location Cytoplasmic, score - - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_458306_3 469616.FMAG_01461 2.25e-91 269.0 COG0041@1|root,COG0041@2|Bacteria,37A3Q@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_458306_4 1278306.KB906911_gene1432 1.49e-141 402.0 COG0152@1|root,COG0152@2|Bacteria,379B2@32066|Fusobacteria 32066|Fusobacteria F Belongs to the SAICAR synthetase family purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_458306_5 469618.FVAG_01155 7.22e-247 688.0 COG0034@1|root,COG0034@2|Bacteria,378PA@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran k59_458306_6 190304.FN0986 3.33e-89 271.0 COG0150@1|root,COG0150@2|Bacteria,378FU@32066|Fusobacteria 32066|Fusobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1013999_1 1049564.TevJSym_ak00580 6.79e-39 139.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1J6IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG3087 Cell division protein ftsN - - ko:K03591 - - - - ko00000,ko03036 - - - SPOR k59_883284_1 1366050.N234_32280 2.05e-59 196.0 COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,2VMYG@28216|Betaproteobacteria,1K3ES@119060|Burkholderiaceae 28216|Betaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_719807_1 290512.Paes_2372 1.15e-12 74.7 COG0641@1|root,COG0641@2|Bacteria,1FEDJ@1090|Chlorobi 1090|Chlorobi C PFAM Radical SAM domain protein - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM k59_392989_1 187272.Mlg_2810 1.46e-56 191.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1WWQB@135613|Chromatiales 135613|Chromatiales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_621767_1 247639.MGP2080_02745 1.48e-83 257.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0501 Zn-dependent protease with chaperone function Z012_09445 - - - - - - - - - - - Peptidase_M48 k59_98748_1 713586.KB900536_gene1423 8.86e-33 118.0 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,1SA62@1236|Gammaproteobacteria,1WYYD@135613|Chromatiales 135613|Chromatiales G system, fructose subfamily IIA component - - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_327646_1 1504981.KO116_1108 5.88e-81 256.0 COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,1S1DS@1236|Gammaproteobacteria,1XNUU@135619|Oceanospirillales 135619|Oceanospirillales G Branched-chain amino acid transport system / permease component - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 k59_327646_2 546271.Selsp_2160 1.6e-20 97.8 COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4H3VQ@909932|Negativicutes 909932|Negativicutes G sugar-binding domain protein rbsB - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_327646_3 742818.HMPREF9451_00313 6.52e-54 191.0 COG2223@1|root,COG2223@2|Bacteria,2I2RR@201174|Actinobacteria,4CYKJ@84998|Coriobacteriia 84998|Coriobacteriia P Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 k59_164160_1 1043493.BBLU01000020_gene1086 7.01e-76 236.0 2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_196772_2 572544.Ilyop_1430 3.96e-121 352.0 COG1521@1|root,COG1521@2|Bacteria,378DN@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_262166_1 1278309.KB907111_gene3365 8.97e-43 152.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1XHFX@135619|Oceanospirillales 135619|Oceanospirillales L ATPase related to the helicase subunit of the Holliday junction resolvase ycaJ - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_262166_2 557598.LHK_01269 6.93e-10 60.1 COG0171@1|root,COG0388@1|root,COG2834@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,COG2834@2|Bacteria,1MU9U@1224|Proteobacteria,2VJ8C@28216|Betaproteobacteria,2KPDJ@206351|Neisseriales 206351|Neisseriales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_719821_1 335543.Sfum_0901 1.49e-76 245.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2MRDP@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2638 PEPCK_C,PEPCK_N k59_785147_1 944547.ABLL_2738 7.03e-22 100.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2YMSH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c oxidase accessory protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_948616_1 273121.WS1342 7.95e-63 208.0 COG0475@1|root,COG0475@2|Bacteria,1R7K4@1224|Proteobacteria,42MF1@68525|delta/epsilon subdivisions,2YM86@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na H antiporter kefB_1 - - - - - - - - - - iIT341.HP1183 Na_H_Exchanger k59_458344_1 994573.T472_0203965 9.39e-09 57.4 COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,36UIY@31979|Clostridiaceae 186801|Clostridia KQ Sigma54 specific transcriptional regulator, Fis family aorR - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat k59_328128_3 1227739.Hsw_PA0090 1.43e-53 176.0 COG3631@1|root,COG3631@2|Bacteria,4NP0M@976|Bacteroidetes 976|Bacteroidetes S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_949096_1 1165841.SULAR_06343 2.48e-10 65.5 COG4967@1|root,COG4967@2|Bacteria 2|Bacteria NU type IV pilus modification protein PilV ppdC - - ko:K02458,ko:K02671,ko:K02681 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15 - - N_methyl,T2SSppdC k59_818331_1 1177928.TH2_14772 1e-40 145.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,2JQ3Z@204441|Rhodospirillales 204441|Rhodospirillales F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_818331_2 526222.Desal_2439 1.65e-29 114.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2M8VQ@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Aminotransferase class I and II yfdZ - 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_949101_1 226186.BT_0758 9.49e-56 181.0 COG3153@1|root,COG3153@2|Bacteria,4NWN0@976|Bacteroidetes,2FSIN@200643|Bacteroidia,4AR8W@815|Bacteroidaceae 976|Bacteroidetes S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_9 k59_949101_2 1121011.AUCB01000001_gene619 3.8e-27 106.0 COG2227@1|root,COG2227@2|Bacteria,4NF6D@976|Bacteroidetes,1HXVW@117743|Flavobacteriia,23I22@178469|Arenibacter 976|Bacteroidetes H Thiopurine S-methyltransferase (TPMT) - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_230040_1 498211.CJA_0733 1.12e-35 137.0 COG1629@1|root,COG4772@1|root,COG1629@2|Bacteria,COG4772@2|Bacteria,1MWTT@1224|Proteobacteria,1RRQ9@1236|Gammaproteobacteria,1FGMT@10|Cellvibrio 1236|Gammaproteobacteria P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_720330_1 706587.Desti_4338 4.01e-101 303.0 COG2502@1|root,COG2502@2|Bacteria,1MVWF@1224|Proteobacteria 1224|Proteobacteria E aspartate--ammonia ligase asnA GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 - R00483 RC00010 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299 AsnA,tRNA-synt_2 k59_883752_1 349521.HCH_00293 3.34e-49 169.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1XJDR@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein with a C-terminal ATPase domain algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_393460_1 765914.ThisiDRAFT_2354 2.69e-85 271.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_752985_1 1005048.CFU_1065 2.9e-37 130.0 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,2VU39@28216|Betaproteobacteria,474U5@75682|Oxalobacteraceae 28216|Betaproteobacteria S MazG-like family - - - - - - - - - - - - MazG-like k59_328138_1 886882.PPSC2_c3391 9.14e-92 306.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_33792_1 713586.KB900536_gene534 6.72e-69 237.0 COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria,1SWBY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_851125_1 1121935.AQXX01000138_gene3119 2.75e-43 161.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH4Q@135619|Oceanospirillales 135619|Oceanospirillales V efflux pump - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_622242_1 527002.yaldo0001_26150 9.23e-22 93.6 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,41E1N@629|Yersinia 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_458870_1 1449345.JHWC01000003_gene464 8.97e-14 77.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2YMUS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the CinA family cinA - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_197270_1 523791.Kkor_1874 6.12e-43 156.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1XIQ4@135619|Oceanospirillales 135619|Oceanospirillales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_131888_2 1237149.C900_03649 2.08e-41 155.0 COG2203@1|root,COG3292@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3292@2|Bacteria,COG4191@2|Bacteria,4NK8Q@976|Bacteroidetes,47M6U@768503|Cytophagia 976|Bacteroidetes KT PFAM Y_Y_Y domain - - - - - - - - - - - - GAF_2,HATPase_c,HTH_18,HisKA,HisKA_2,Reg_prop,Response_reg,SpoIIE,Y_Y_Y k59_818360_1 1165841.SULAR_06233 5.64e-119 352.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2YMR4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_198262_1 1168034.FH5T_11815 1.89e-35 127.0 COG2865@1|root,COG2865@2|Bacteria,4NGPG@976|Bacteroidetes,2FMWB@200643|Bacteroidia 976|Bacteroidetes K Divergent AAA domain protein - - - - - - - - - - - - AlbA_2 k59_198262_2 1168034.FH5T_11810 8.36e-100 301.0 COG1785@1|root,COG1785@2|Bacteria,4NG3D@976|Bacteroidetes,2FMNA@200643|Bacteroidia 976|Bacteroidetes P Belongs to the alkaline phosphatase family phoA - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_34523_2 526227.Mesil_0570 3.92e-38 154.0 COG0507@1|root,COG1112@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria 2|Bacteria L Superfamily I DNA and RNA helicases and helicase subunits - - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_11,AAA_12,AAA_30,PDDEXK_1,UvrD_C_2,Viral_helicase1 k59_133076_1 709991.Odosp_2900 2.56e-121 360.0 COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,2FNV5@200643|Bacteroidia,22Y2P@171551|Porphyromonadaceae 976|Bacteroidetes E Pyridoxal-phosphate dependent enzyme ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_721394_1 1117108.PAALTS15_18683 3.07e-06 52.4 COG1051@1|root,COG1051@2|Bacteria,1VC1Q@1239|Firmicutes,4HMSE@91061|Bacilli,26YR9@186822|Paenibacillaceae 91061|Bacilli F Belongs to the Nudix hydrolase family - - - - - - - - - - - - NUDIX k59_721394_2 997296.PB1_01255 8.09e-59 193.0 COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,4HAWU@91061|Bacilli,1ZAPM@1386|Bacillus 91061|Bacilli J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_721394_6 762948.HMPREF0733_12126 5.23e-30 134.0 COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,1W7K7@1268|Micrococcaceae 201174|Actinobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_753843_1 1249480.B649_10475 3.88e-119 360.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2YMUE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_361987_2 572544.Ilyop_0229 4.84e-66 213.0 COG4106@1|root,COG4106@2|Bacteria 2|Bacteria FG trans-aconitate 2-methyltransferase activity tam GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016740,GO:0016741,GO:0030798,GO:0031347,GO:0031348,GO:0032259,GO:0035821,GO:0040007,GO:0043207,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045088,GO:0045824,GO:0046467,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0071704,GO:0075136,GO:0080134,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.1.1.144,2.1.1.187,2.1.1.197,2.1.1.265,2.5.1.38,6.3.3.3 ko:K00563,ko:K00598,ko:K01935,ko:K02169,ko:K14251,ko:K15256,ko:K16868,ko:K19104 ko00253,ko00261,ko00780,ko01057,ko01100,ko01130,map00253,map00261,map00780,map01057,map01100,map01130 M00123,M00572,M00573,M00577,M00736,M00780,M00823 R03072,R03182,R07233,R09189,R09543,R10881 RC00003,RC00021,RC00460,RC00868,RC01372,RC01662 ko00000,ko00001,ko00002,ko01000,ko03009,ko03016 - - iECABU_c1320.ECABU_c17460,iSDY_1059.SDY_1625,ic_1306.c1942 Methyltransf_11,Methyltransf_19,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_361987_3 469616.FMAG_01192 8e-120 348.0 COG1212@1|root,COG1212@2|Bacteria,378DT@32066|Fusobacteria 32066|Fusobacteria M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_656258_1 87626.PTD2_02316 1.75e-27 114.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,2PZHR@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG2199 FOG GGDEF domain pleD - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_34526_1 1168034.FH5T_19000 7.35e-49 160.0 COG2246@1|root,COG2246@2|Bacteria,4NSQN@976|Bacteroidetes,2FTT4@200643|Bacteroidia 976|Bacteroidetes S GtrA-like protein - - - - - - - - - - - - GtrA k59_950268_1 313628.LNTAR_17363 2.22e-66 230.0 COG1283@1|root,COG1283@2|Bacteria 2|Bacteria P sodium-dependent phosphate transmembrane transporter activity phoU_1 - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_329292_1 1353531.AZNX01000002_gene4740 6.01e-27 107.0 COG4430@1|root,COG4430@2|Bacteria,1NEN6@1224|Proteobacteria,2U6FE@28211|Alphaproteobacteria,4BC4Y@82115|Rhizobiaceae 28211|Alphaproteobacteria S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - OmdA k59_361990_2 1122134.KB893650_gene818 1.05e-56 192.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1SZZ0@1236|Gammaproteobacteria,1XRP7@135619|Oceanospirillales 135619|Oceanospirillales V MatE - - - - - - - - - - - - MatE k59_753848_1 401526.TcarDRAFT_2071 1.37e-06 54.7 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H2BH@909932|Negativicutes 909932|Negativicutes KLT serine threonine protein kinase prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_394507_1 387093.SUN_2268 4.58e-49 165.0 COG0704@1|root,COG0704@2|Bacteria,1Q5TJ@1224|Proteobacteria,42STN@68525|delta/epsilon subdivisions,2YPRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P PhoU family - - - ko:K02039 - - - - ko00000 - - - PhoU k59_852348_1 1408473.JHXO01000006_gene1235 8.92e-28 112.0 COG0665@1|root,COG0665@2|Bacteria,4NFCD@976|Bacteroidetes 976|Bacteroidetes E fad dependent oxidoreductase thiO - - - - - - - - - - - DAO k59_198272_1 225117.XP_009366572.1 6.18e-09 56.2 2CV7H@1|root,2RRGK@2759|Eukaryota,383A9@33090|Viridiplantae,3GS0R@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_1015441_2 293826.Amet_2316 2.99e-60 188.0 COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,36JHE@31979|Clostridiaceae 186801|Clostridia J endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_1015441_3 572544.Ilyop_0032 3.44e-130 378.0 COG0564@1|root,COG0564@2|Bacteria,37892@32066|Fusobacteria 32066|Fusobacteria J Responsible for synthesis of pseudouridine from uracil - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_1015441_4 526218.Sterm_0230 3.29e-203 566.0 COG0057@1|root,COG0057@2|Bacteria,378AH@32066|Fusobacteria 32066|Fusobacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1015441_5 6211.A0A068YDR2 2.84e-06 48.5 COG0126@1|root,KOG1367@2759|Eukaryota,38EF9@33154|Opisthokonta,3BE59@33208|Metazoa,3CT3V@33213|Bilateria 33208|Metazoa G phosphoglycerate kinase activity pgk-1 GO:0000166,GO:0000768,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006949,GO:0007154,GO:0007267,GO:0007268,GO:0007520,GO:0007525,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009653,GO:0009987,GO:0014902,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019725,GO:0019752,GO:0023052,GO:0030016,GO:0030017,GO:0030018,GO:0030154,GO:0030554,GO:0031430,GO:0031672,GO:0031674,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035639,GO:0036094,GO:0042592,GO:0042692,GO:0042866,GO:0043167,GO:0043168,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046716,GO:0046939,GO:0048646,GO:0048856,GO:0048869,GO:0051146,GO:0051186,GO:0051188,GO:0055086,GO:0060249,GO:0061061,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:0098916,GO:0099080,GO:0099081,GO:0099512,GO:0099536,GO:0099537,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_34535_1 1463864.JOGO01000001_gene1727 2.58e-54 192.0 COG0236@1|root,COG0500@1|root,COG2898@1|root,COG3321@1|root,COG0236@2|Bacteria,COG2226@2|Bacteria,COG2898@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria 201174|Actinobacteria Q polyketide synthase - - - - - - - - - - - - Abhydrolase_1,Beta_elim_lyase,DUF2156,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_884548_3 929556.Solca_0293 2.5e-07 53.1 COG2304@1|root,COG2304@2|Bacteria,4NER3@976|Bacteroidetes,1IRAV@117747|Sphingobacteriia 976|Bacteroidetes S oxidoreductase activity - - - - - - - - - - - - - k59_263468_1 323850.Shew_3036 9.48e-09 55.5 COG0121@1|root,COG0121@2|Bacteria,1QJEC@1224|Proteobacteria,1THDQ@1236|Gammaproteobacteria,2QDRP@267890|Shewanellaceae 1236|Gammaproteobacteria S Glutamine amidotransferases class-II - - - - - - - - - - - - GATase_4 k59_263468_2 1470591.BW41_02308 2.98e-21 85.9 2C91B@1|root,33D4Z@2|Bacteria,1NG8C@1224|Proteobacteria,2UIXT@28211|Alphaproteobacteria,2K71B@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_133101_1 1123392.AQWL01000002_gene1908 1.96e-06 48.9 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,1KRI8@119069|Hydrogenophilales 119069|Hydrogenophilales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_133101_2 765911.Thivi_2347 7.23e-116 338.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1WXC0@135613|Chromatiales 135613|Chromatiales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_492580_1 1335757.SPICUR_07680 2.01e-58 185.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1WYVR@135613|Chromatiales 135613|Chromatiales K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_492580_2 78398.KS43_08005 7.92e-125 366.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1MQTZ@122277|Pectobacterium 1236|Gammaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_492580_3 85643.Tmz1t_3434 9.44e-19 80.5 COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,2KWVG@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_492580_4 713586.KB900536_gene1379 6.16e-209 601.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_492580_5 1049564.TevJSym_aj00350 1.37e-177 516.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1J4PM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_492580_6 1249627.D779_1229 1.65e-150 443.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1WWTC@135613|Chromatiales 135613|Chromatiales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_492580_7 1198232.CYCME_2286 5.23e-194 545.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,4604R@72273|Thiotrichales 72273|Thiotrichales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_492580_8 1049564.TevJSym_aj00320 4.22e-181 520.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1J5GI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Mur_ligase_C,Mur_ligase_M k59_492580_9 1049564.TevJSym_aj00310 1.09e-154 449.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1J5FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell division ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_492580_10 713586.KB900536_gene1373 4.61e-133 391.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_492580_11 631362.Thi970DRAFT_02125 1.96e-43 155.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1WW6B@135613|Chromatiales 135613|Chromatiales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_753865_1 857087.Metme_2082 2.82e-67 216.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,1RZ9I@1236|Gammaproteobacteria,1XDNR@135618|Methylococcales 135618|Methylococcales I alpha/beta hydrolase fold - - - - - - - - - - - - Hydrolase_4 k59_525948_1 1536773.R70331_11690 5.96e-86 268.0 COG2207@1|root,COG2207@2|Bacteria,1V3YU@1239|Firmicutes,4IUMC@91061|Bacilli,26TC3@186822|Paenibacillaceae 91061|Bacilli K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 k59_819965_1 338963.Pcar_1084 1.39e-128 378.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase IS200 like - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_264018_3 1335757.SPICUR_00350 3.11e-13 67.8 COG1826@1|root,COG1826@2|Bacteria 2|Bacteria U protein secretion tatB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_264018_4 555778.Hneap_0117 1.82e-13 67.0 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1WZ7B@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_231738_1 380394.Lferr_1061 1.78e-09 57.8 COG1109@1|root,COG1109@2|Bacteria,1MUB3@1224|Proteobacteria,1RNFZ@1236|Gammaproteobacteria,2NCJ0@225057|Acidithiobacillales 225057|Acidithiobacillales G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_231738_2 765911.Thivi_3231 2.27e-21 90.1 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1WXHN@135613|Chromatiales 135613|Chromatiales Q PFAM toluene tolerance - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_623847_1 349521.HCH_01434 1.73e-54 181.0 COG3271@1|root,COG4783@1|root,COG3271@2|Bacteria,COG4783@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,1XRU4@135619|Oceanospirillales 135619|Oceanospirillales S FOG TPR repeat - - - - - - - - - - - - Peptidase_C39_2,Peptidase_C70,TPR_16,TPR_8 k59_460689_1 572480.Arnit_2239 7.66e-24 98.6 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2YME1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M heptosyltransferase ii waaF - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_460689_2 28258.KP05_01795 5.74e-27 109.0 COG0438@1|root,COG0438@2|Bacteria,1R7VT@1224|Proteobacteria,1SYK1@1236|Gammaproteobacteria,1XK90@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_329894_1 396588.Tgr7_1832 3.17e-120 358.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales 135613|Chromatiales EH Anthranilate synthase component I - - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_329894_2 1049564.TevJSym_bc00180 6.64e-19 85.5 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1J6F6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH COG0115 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase pabC GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008696,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042558,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_177,iE2348C_1286.E2348C_1188,iECED1_1282.ECED1_1239,iECNA114_1301.ECNA114_1153,iECOK1_1307.ECOK1_1203,iECS88_1305.ECS88_1110,iECSF_1327.ECSF_0995,iECUMN_1333.ECUMN_1273,iJN746.PP_1917,iPC815.YPO1603,iUMN146_1321.UM146_11845,iUTI89_1310.UTI89_C1222,ic_1306.c1366 Aminotran_4 k59_231740_1 439235.Dalk_3642 1.88e-57 199.0 COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1N4M6@1224|Proteobacteria,42M38@68525|delta/epsilon subdivisions,2WIR0@28221|Deltaproteobacteria,2MJ85@213118|Desulfobacterales 28221|Deltaproteobacteria T sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - GAF_2,HTH_8,PAS_3,PAS_4,PAS_9,Sigma54_activat k59_100915_1 933262.AXAM01000001_gene408 2.88e-13 64.7 COG2929@1|root,COG2929@2|Bacteria,1N8PW@1224|Proteobacteria,42V50@68525|delta/epsilon subdivisions,2WRZB@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - - - - - - - - - - BrnT_toxin k59_100915_2 1128427.KB904821_gene1863 1.2e-09 55.8 2EMFR@1|root,33F4G@2|Bacteria,1GATI@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_100915_3 1232683.ADIMK_3117 1.61e-34 124.0 COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,1RPDF@1236|Gammaproteobacteria,465M9@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase eda GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008675,GO:0008700,GO:0008948,GO:0016829,GO:0016830,GO:0016831,GO:0016832,GO:0016833,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0106009 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - iECOK1_1307.ECOK1_1968,iYL1228.KPN_02365 Aldolase k59_1016036_1 1453501.JELR01000001_gene3247 3.07e-43 153.0 COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,466ZS@72275|Alteromonadaceae 1236|Gammaproteobacteria S Secreted protein, containing von Willebrand factor - - - - - - - - - - - - - k59_68001_1 1336803.PHEL49_2629 6.11e-105 339.0 COG0457@1|root,COG3206@1|root,COG0457@2|Bacteria,COG3206@2|Bacteria,4NH33@976|Bacteroidetes,1HYMC@117743|Flavobacteriia,3VX4T@52959|Polaribacter 976|Bacteroidetes M ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_623857_2 648996.Theam_0654 1.34e-07 54.7 COG1087@1|root,COG1087@2|Bacteria,2G3QB@200783|Aquificae 200783|Aquificae M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_329904_1 1370122.JHXQ01000002_gene2852 1.16e-38 142.0 COG3385@1|root,COG3385@2|Bacteria,1R8M9@1224|Proteobacteria,2UI32@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_133796_1 555088.DealDRAFT_0437 1.62e-45 162.0 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,42JI8@68298|Syntrophomonadaceae 186801|Clostridia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_819986_1 762968.HMPREF9441_01742 5.66e-09 62.8 COG0471@1|root,COG3273@1|root,COG0471@2|Bacteria,COG3273@2|Bacteria,4NF52@976|Bacteroidetes,2FM64@200643|Bacteroidia 976|Bacteroidetes P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_68011_1 1168034.FH5T_14035 3.9e-65 213.0 COG0364@1|root,COG0364@2|Bacteria,4NE59@976|Bacteroidetes,2FNER@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_264037_1 314278.NB231_04420 4.54e-14 66.2 COG5304@1|root,COG5304@2|Bacteria,1NBCZ@1224|Proteobacteria,1SCSH@1236|Gammaproteobacteria,1WZ60@135613|Chromatiales 135613|Chromatiales S protein conserved in bacteria - - - - - - - - - - - - - k59_100931_1 929558.SMGD1_2849 5.5e-05 45.8 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2YP5V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NOU Peptidase A24 pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_100931_3 1089553.Tph_c16630 6.95e-06 48.5 COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,42F7Z@68295|Thermoanaerobacterales 186801|Clostridia U PFAM Type II secretion system F domain - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_427539_1 572480.Arnit_1822 7.33e-06 48.1 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2YMQ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_427539_2 563040.Saut_0114 1.67e-75 238.0 COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,42P5E@68525|delta/epsilon subdivisions,2YN01@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Fad-dependent pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_395123_1 1537917.JU82_05060 4.28e-135 405.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2YN94@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_689344_1 1249480.B649_07435 4.46e-10 60.1 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2YMJ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mur ligase middle domain murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_689344_2 563040.Saut_0945 2.71e-58 186.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,42SCS@68525|delta/epsilon subdivisions,2YPIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Tripartite ATP-independent periplasmic transporter DctQ component - - - - - - - - - - - - DctQ k59_231753_1 1249480.B649_11640 1.33e-119 361.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2YMWQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_918412_1 1384056.N787_01430 2.36e-45 160.0 COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria,1X4R5@135614|Xanthomonadales 135614|Xanthomonadales S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_68014_1 1121271.AUCM01000028_gene56 1.87e-195 541.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_68014_2 1101189.AQUO01000001_gene2023 2.13e-54 170.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UD7K@28211|Alphaproteobacteria,2PZ9E@265|Paracoccus 28211|Alphaproteobacteria L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_656978_1 1168034.FH5T_17785 3.05e-35 129.0 COG3828@1|root,COG3828@2|Bacteria,4NEWH@976|Bacteroidetes,2FQY6@200643|Bacteroidia 976|Bacteroidetes S Methane oxygenase PmoA - - - - - - - - - - - - PmoA k59_787777_1 387093.SUN_1018 3.79e-39 132.0 COG2161@1|root,COG2161@2|Bacteria,1N8QY@1224|Proteobacteria,42WS8@68525|delta/epsilon subdivisions,2YQ0I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox k59_951504_1 99598.Cal7507_1941 5.08e-23 89.7 COG3514@1|root,COG3514@2|Bacteria,1G7ND@1117|Cyanobacteria,1HPP8@1161|Nostocales 1117|Cyanobacteria S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_951504_2 1267535.KB906767_gene5248 7.32e-20 83.6 COG2929@1|root,COG2929@2|Bacteria,3Y5X2@57723|Acidobacteria,2JK3U@204432|Acidobacteriia 204432|Acidobacteriia S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_297392_1 1249627.D779_1619 7.14e-53 179.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,1RP8V@1236|Gammaproteobacteria,1WXFT@135613|Chromatiales 135613|Chromatiales M D-Ala-D-Ala carboxypeptidase - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_232239_1 572544.Ilyop_1819 3.55e-108 323.0 COG2870@1|root,COG2870@2|Bacteria,378KV@32066|Fusobacteria 32066|Fusobacteria M Psort location Cytoplasmic, score rfaE1 - - - - - - - - - - - PfkB k59_232239_2 1506994.JNLQ01000002_gene1444 8.62e-53 171.0 COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,4BX0E@830|Butyrivibrio 186801|Clostridia I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_395682_1 1120951.AUBG01000025_gene1839 6.73e-34 140.0 COG1404@1|root,COG3291@1|root,COG4935@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4935@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - CHU_C,DUF11,Reprolysin_4,SLH,fn3 k59_820529_3 445973.CLOBAR_00531 3.15e-103 310.0 COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,25R9M@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS12020 NadA k59_820529_4 941824.TCEL_01394 1.05e-146 431.0 COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,36EIS@31979|Clostridiaceae 186801|Clostridia H L-aspartate oxidase nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_820529_5 714943.Mucpa_5806 7.63e-07 52.4 COG0157@1|root,COG0157@2|Bacteria,4NDXF@976|Bacteroidetes,1INNF@117747|Sphingobacteriia 976|Bacteroidetes H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_68606_1 1165841.SULAR_05113 8.98e-46 156.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2YMPG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_68606_2 387093.SUN_1614 1.98e-45 150.0 COG2862@1|root,COG2862@2|Bacteria,1RFUX@1224|Proteobacteria,42T0B@68525|delta/epsilon subdivisions,2YP5M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane - - - - - - - - - - - - UPF0114 k59_232241_1 457421.CBFG_00055 1.32e-25 99.0 COG1433@1|root,COG1433@2|Bacteria 2|Bacteria S nitrogen fixation - - - - - - - - - - - - C_GCAxxG_C_C k59_232241_2 457421.CBFG_00059 1.5e-159 455.0 COG2207@1|root,COG2207@2|Bacteria,1V1RQ@1239|Firmicutes,24C1H@186801|Clostridia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC k59_297403_1 477228.YO5_10255 2.11e-67 214.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1YZX0@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2492,iJN746.PP_1237,iYL1228.KPN_02812 DHDPS k59_919071_1 1165841.SULAR_03782 1.45e-69 230.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2YMSQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II k59_919071_2 1165841.SULAR_03787 3.63e-12 61.6 29Y6B@1|root,30JZQ@2|Bacteria,1R1Q3@1224|Proteobacteria,43DAV@68525|delta/epsilon subdivisions,2YR17@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - AMPK1_CBM k59_101599_1 985255.APHJ01000037_gene2857 8.12e-47 157.0 COG0207@1|root,COG0207@2|Bacteria,4NEC2@976|Bacteroidetes,1HX2F@117743|Flavobacteriia,2P5KZ@244698|Gillisia 976|Bacteroidetes F Thymidylate synthase thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_395692_2 1123256.KB907926_gene797 2.67e-22 92.4 COG3151@1|root,COG3151@2|Bacteria,1MYG8@1224|Proteobacteria,1S7P6@1236|Gammaproteobacteria,1X7UD@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1249) - - - ko:K09920 - - - - ko00000 - - - DUF1249 k59_232246_2 225937.HP15_3595 4.26e-28 112.0 COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,1RRA7@1236|Gammaproteobacteria,464FY@72275|Alteromonadaceae 1236|Gammaproteobacteria S zinc-ribbon domain - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_297405_2 1244528.CFT03427_0437 7.58e-77 235.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,42U26@68525|delta/epsilon subdivisions,2YQ4F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K transcriptional regulator, Crp - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_983860_1 1122179.KB890436_gene1339 4.17e-09 59.7 COG1488@1|root,COG1488@2|Bacteria 2|Bacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - iYO844.BSU31750 NAPRTase k59_134388_1 293826.Amet_1281 4.68e-33 125.0 COG4512@1|root,COG4512@2|Bacteria,1VF1N@1239|Firmicutes,24SCM@186801|Clostridia,36HYN@31979|Clostridiaceae 186801|Clostridia KOT PFAM Accessory gene regulator B - - - ko:K07813 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001,ko01002 - - - AgrB k59_134388_3 999411.HMPREF1092_00473 7.98e-151 450.0 COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GGDEF,HD,HD_5 k59_134397_1 644282.Deba_0006 6.06e-16 81.3 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase HAMP - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 k59_559436_1 1168034.FH5T_12780 2.79e-102 317.0 COG2274@1|root,COG2274@2|Bacteria,4NE19@976|Bacteroidetes,2FNRE@200643|Bacteroidia 976|Bacteroidetes V ABC transporter, ATP-binding protein - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_264556_1 1126627.BAWE01000002_gene792 5.93e-42 144.0 COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,2U7T5@28211|Alphaproteobacteria,3JV3K@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_25 k59_264556_2 1385515.N791_00930 1.91e-32 119.0 COG0500@1|root,COG0500@2|Bacteria,1RDHE@1224|Proteobacteria,1S3U0@1236|Gammaproteobacteria,1X6QC@135614|Xanthomonadales 135614|Xanthomonadales Q Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_1016654_2 572480.Arnit_0234 5.49e-17 77.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42TDG@68525|delta/epsilon subdivisions,2YPNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_461381_1 1108045.GORHZ_078_00120 2.78e-41 150.0 COG0025@1|root,COG0025@2|Bacteria,2GKCK@201174|Actinobacteria,4GAJY@85026|Gordoniaceae 201174|Actinobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_1016657_1 713586.KB900536_gene1304 3.54e-05 47.8 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria 1224|Proteobacteria T PFAM Forkhead-associated protein - - - - - - - - - - - - FHA,Yop-YscD_cpl k59_820564_1 1033802.SSPSH_003037 1.97e-71 239.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046487,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_436,iECOK1_1307.ECOK1_1491,iECS88_1305.ECS88_1416,iJN746.PP_2112,iUMN146_1321.UM146_10390,iUTI89_1310.UTI89_C1547 Aconitase,Aconitase_C k59_35706_1 1165841.SULAR_01285 6.13e-51 166.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RJP@68525|delta/epsilon subdivisions,2YP82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG1881 Phospholipid-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_853630_3 679189.HMPREF9019_1119 4.54e-76 242.0 COG3440@1|root,COG3440@2|Bacteria,4NT7F@976|Bacteroidetes,2FVGI@200643|Bacteroidia 976|Bacteroidetes V HNH endonuclease - - - - - - - - - - - - HNH_2 k59_853630_4 546266.NEIMUCOT_05911 2.98e-72 228.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2VIFH@28216|Betaproteobacteria,2KQZK@206351|Neisseriales 28216|Betaproteobacteria H Psort location Cytoplasmic, score 8.96 nlaXM - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase,HTH_3 k59_167545_1 1168034.FH5T_14985 2.68e-09 57.4 COG2972@1|root,COG2972@2|Bacteria,4NK09@976|Bacteroidetes,2FNWE@200643|Bacteroidia 976|Bacteroidetes T Histidine kinase ypdA_4 - - - - - - - - - - - HATPase_c_5,His_kinase k59_167545_2 1168034.FH5T_14980 3.2e-75 230.0 COG3279@1|root,COG3279@2|Bacteria,4NIXU@976|Bacteroidetes,2FTQZ@200643|Bacteroidia 976|Bacteroidetes T LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_624728_1 1163617.SCD_n00685 1.1e-168 528.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_984169_2 749222.Nitsa_1758 3.52e-44 154.0 COG5557@1|root,COG5557@2|Bacteria,1R54P@1224|Proteobacteria,42N9S@68525|delta/epsilon subdivisions,2YN90@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Polysulphide reductase NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_788097_1 1504672.669786077 1.46e-117 355.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2VHTR@28216|Betaproteobacteria,4AB3G@80864|Comamonadaceae 28216|Betaproteobacteria S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP k59_264821_1 1504981.KO116_1267 3.28e-22 93.2 COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1XQE6@135619|Oceanospirillales 135619|Oceanospirillales N Protein required for attachment to host cells - - - - - - - - - - - - Host_attach k59_919387_1 1137271.AZUM01000003_gene3731 3.17e-06 53.9 COG2133@1|root,COG3291@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria,4E1CS@85010|Pseudonocardiales 201174|Actinobacteria G glucose sorbosone - - - - - - - - - - - - CBM_6,DUF1080,GSDH,PKD,ThuA k59_951695_1 572544.Ilyop_2845 4.34e-111 337.0 COG1053@1|root,COG1053@2|Bacteria,37AQS@32066|Fusobacteria 32066|Fusobacteria C fumarate reductase succinate dehydrogenase flavoprotein domain protein - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_984176_2 1168034.FH5T_09545 2.61e-38 136.0 COG1475@1|root,COG1475@2|Bacteria,4NFZ9@976|Bacteroidetes,2FP81@200643|Bacteroidia 976|Bacteroidetes K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_68934_1 1165841.SULAR_10124 4.01e-182 517.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2YN1J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase - - - - - - - - - - - - Aminotran_5 k59_68934_2 1165841.SULAR_10129 1.83e-35 134.0 COG2956@1|root,COG2956@2|Bacteria,1PDTB@1224|Proteobacteria,42PNY@68525|delta/epsilon subdivisions,2YN3M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the low molecular weight phosphotyrosine protein phosphatase family ciaB - - - - - - - - - - - - k59_35965_1 1168034.FH5T_05825 5.62e-89 275.0 COG4784@1|root,COG4784@2|Bacteria,4PM59@976|Bacteroidetes 976|Bacteroidetes S Peptidase M48 - - - - - - - - - - - - Peptidase_M48 k59_820847_1 580327.Tthe_2353 2.36e-07 61.2 COG1520@1|root,COG3325@1|root,COG1520@2|Bacteria,COG3325@2|Bacteria,1UPJ7@1239|Firmicutes,24D95@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 18 family - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - CHB_HEX_C_1,ChitinaseA_N,Glyco_hydro_18 k59_297679_1 318996.AXAZ01000027_gene1611 4.72e-05 50.4 COG2199@1|root,COG3706@2|Bacteria,1R6Q0@1224|Proteobacteria,2U0GW@28211|Alphaproteobacteria,3JUCS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T diguanylate cyclase - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_167571_1 629773.AORY01000014_gene2523 7.75e-31 125.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_820851_1 929558.SMGD1_1185 2.66e-50 177.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2YMTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_657957_1 745014.OMB55_00002620 1.06e-09 64.7 COG4773@1|root,COG4773@2|Bacteria,1MWUQ@1224|Proteobacteria 1224|Proteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_494189_1 4572.TRIUR3_00337-P1 9.27e-13 64.3 COG0049@1|root,KOG3291@2759|Eukaryota,37YX8@33090|Viridiplantae,3GNS6@35493|Streptophyta,3KTYP@4447|Liliopsida,3IAPX@38820|Poales 35493|Streptophyta J ribosomal protein S7 - - - - - - - - - - - - Ribosomal_S7 k59_984181_1 1123009.AUID01000005_gene1619 4.77e-95 288.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,2689V@186813|unclassified Clostridiales 186801|Clostridia EP Oligopeptide/dipeptide transporter, C-terminal region oppD - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_984181_2 1123284.KB899042_gene1316 4.4e-134 390.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,26P9S@186821|Sporolactobacillaceae 91061|Bacilli E Belongs to the ABC transporter superfamily - - - - - - - - - - - - ABC_tran,oligo_HPY k59_199628_1 75379.Tint_0741 6.25e-63 199.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2VKKJ@28216|Betaproteobacteria,1KJEQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_527002_1 1047013.AQSP01000089_gene1181 6.97e-17 85.5 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process cyaJ - 4.6.1.1 ko:K01768,ko:K02483 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko02022 - - - Guanylate_cyc,HTH_18,TPR_16,TPR_19,TPR_2,TPR_8 k59_788115_2 882.DVU_0826 3.26e-06 53.9 COG0247@1|root,COG0247@2|Bacteria,1RE3X@1224|Proteobacteria,42RUA@68525|delta/epsilon subdivisions,2WNZF@28221|Deltaproteobacteria,2M8Q8@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_8 k59_624732_1 573413.Spirs_3971 4.93e-181 515.0 COG0673@1|root,COG0673@2|Bacteria,2J6QZ@203691|Spirochaetes 203691|Spirochaetes S Oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA k59_624732_2 1225184.ALXE01000025_gene2170 8.51e-136 391.0 COG1082@1|root,COG1082@2|Bacteria,1NISG@1224|Proteobacteria,1S0FC@1236|Gammaproteobacteria,3W2RS@53335|Pantoea 1236|Gammaproteobacteria G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_624732_3 484770.UFO1_3159 3.24e-65 216.0 COG1609@1|root,COG1609@2|Bacteria,1TSRM@1239|Firmicutes,4H28Y@909932|Negativicutes 909932|Negativicutes K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_4 k59_461741_1 631362.Thi970DRAFT_04894 2.71e-50 170.0 295V5@1|root,2ZT65@2|Bacteria,1REG0@1224|Proteobacteria,1S9HA@1236|Gammaproteobacteria,1WYWE@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_591598_1 929558.SMGD1_2267 9.6e-26 99.4 COG0711@1|root,COG0711@2|Bacteria,1Q2G9@1224|Proteobacteria,42VN4@68525|delta/epsilon subdivisions,2YQBE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the ATPase B chain family atpF' - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_591598_2 709032.Sulku_0755 2.45e-53 173.0 COG0711@1|root,COG0711@2|Bacteria,1Q9TP@1224|Proteobacteria,42U87@68525|delta/epsilon subdivisions,2YPT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_1016959_1 1265505.ATUG01000001_gene3999 1.72e-54 182.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,2MIT3@213118|Desulfobacterales 28221|Deltaproteobacteria O hydrogenase expression formation protein HypD hypD - - ko:K04654 - - - - ko00000 - - iAF987.Gmet_0117 HypD k59_1016959_2 999419.HMPREF1077_02994 1.78e-24 100.0 COG0309@1|root,COG0309@2|Bacteria,4NG57@976|Bacteroidetes,2FNVB@200643|Bacteroidia,22WZP@171551|Porphyromonadaceae 976|Bacteroidetes O AIR synthase related protein, N-terminal domain - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_461743_1 765911.Thivi_2482 2.66e-84 260.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1WVVR@135613|Chromatiales 135613|Chromatiales M PFAM glycosyl transferase family 9 - - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_167588_1 1232683.ADIMK_4201 5.27e-76 254.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,464IC@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG0477 Permeases of the major facilitator superfamily - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_297696_1 1535422.ND16A_3846 6.41e-60 198.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,2Q5VY@267889|Colwelliaceae 1236|Gammaproteobacteria M Opacity-associated protein A LysM-like domain yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_297696_2 1157708.KB907457_gene2778 1.66e-06 50.8 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,4AAHZ@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_167590_1 1121422.AUMW01000013_gene1471 1.15e-12 69.7 COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,24BSX@186801|Clostridia,264DF@186807|Peptococcaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07710 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_167590_2 933262.AXAM01000002_gene562 1.78e-61 192.0 COG2204@1|root,COG2204@2|Bacteria,1RGQT@1224|Proteobacteria,42RK9@68525|delta/epsilon subdivisions,2WMYQ@28221|Deltaproteobacteria,2MJRF@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_559767_1 1168034.FH5T_16330 5.52e-100 295.0 COG1694@1|root,COG3956@2|Bacteria,4NEA3@976|Bacteroidetes,2FKYP@200643|Bacteroidia 976|Bacteroidetes S MazG family mazG - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - MazG k59_591613_1 1269813.ATUL01000012_gene434 3.62e-28 109.0 COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria 1224|Proteobacteria M Outer Membrane Lipoprotein slp GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 - ko:K07285 - - - - ko00000 - - - Slp k59_788129_1 1249480.B649_08145 1.34e-29 113.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,42N1M@68525|delta/epsilon subdivisions,2YN3T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_690698_2 709032.Sulku_1992 2.69e-59 184.0 COG3370@1|root,COG3370@2|Bacteria,1N27G@1224|Proteobacteria,42UAJ@68525|delta/epsilon subdivisions,2YPZ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM DsrE DsrF-like family - - - - - - - - - - - - DrsE k59_69514_1 1521187.JPIM01000124_gene3628 4.72e-154 465.0 COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi 200795|Chloroflexi P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_168242_1 1249480.B649_11200 3.87e-61 196.0 COG1427@1|root,COG1427@2|Bacteria,1RCS0@1224|Proteobacteria,42MJZ@68525|delta/epsilon subdivisions,2YN8T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnA - 4.2.1.151 ko:K11782 ko00130,ko01110,map00130,map01110 - R10666 RC03232 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_135438_2 1165841.SULAR_04212 4.31e-20 87.0 COG2733@1|root,COG2733@2|Bacteria,1R4JT@1224|Proteobacteria,42RK1@68525|delta/epsilon subdivisions,2YPBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_36571_1 1163617.SCD_n01736 3.62e-145 424.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria 28216|Betaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_265376_1 883126.HMPREF9710_04457 3.28e-64 199.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,474AU@75682|Oxalobacteraceae 28216|Betaproteobacteria O Thioredoxin trxC - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin k59_200205_1 1168034.FH5T_05730 2.89e-103 308.0 COG3876@1|root,COG3876@2|Bacteria,4NEXD@976|Bacteroidetes,2FN5Q@200643|Bacteroidia 976|Bacteroidetes S protein conserved in bacteria - - - - - - - - - - - - DUF1343 k59_135451_1 1165841.SULAR_07113 1.23e-55 187.0 COG0642@1|root,COG0642@2|Bacteria,1N5IQ@1224|Proteobacteria,42M9P@68525|delta/epsilon subdivisions,2YN0U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase cprS - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_265379_1 1168034.FH5T_18260 1.23e-144 417.0 COG3385@1|root,COG3385@2|Bacteria,4NHKV@976|Bacteroidetes,2FPZQ@200643|Bacteroidia 976|Bacteroidetes L COG COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_821527_1 1163617.SCD_n00121 2.59e-37 127.0 2EI6M@1|root,33BXY@2|Bacteria,1NGAW@1224|Proteobacteria,2W5PE@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_821527_3 755732.Fluta_1412 1.9e-55 182.0 2EWFP@1|root,33PU3@2|Bacteria,4P0EJ@976|Bacteroidetes 976|Bacteroidetes S by Glimmer2 - - - - - - - - - - - - - k59_984770_1 1168034.FH5T_16615 3.71e-98 305.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,4NGF6@976|Bacteroidetes,2FNTX@200643|Bacteroidia 976|Bacteroidetes P TrkA C-terminal domain protein kefC - - ko:K03455,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.2 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_69540_1 1121015.N789_02985 1.03e-81 263.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1X4DX@135614|Xanthomonadales 135614|Xanthomonadales P Nitric oxide reductase large subunit - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_920023_1 1172190.M947_03780 6.33e-87 268.0 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QYV@68525|delta/epsilon subdivisions,2YNW5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Jag_N - - - ko:K06346 - - - - ko00000 - - - Jag_N k59_428840_2 1333856.L686_09300 6.67e-62 213.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1Z29G@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1017587_1 448385.sce6976 1.86e-35 144.0 COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria 2|Bacteria C ATP:ADP antiporter activity - - - ko:K01932,ko:K03301 - - - - ko00000,ko01000 2.A.12 - - Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC k59_788723_1 557598.LHK_00704 4e-111 323.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VIJC@28216|Betaproteobacteria,2KPI7@206351|Neisseriales 206351|Neisseriales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_560402_1 1469245.JFBG01000027_gene1455 1.26e-52 173.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_625340_1 377629.TERTU_4452 2.67e-134 387.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RYX7@1236|Gammaproteobacteria,2PQJR@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L hmm pf00665 - - - - - - - - - - - - HTH_21,rve k59_625340_2 377629.TERTU_2182 4.11e-62 191.0 COG2963@1|root,COG2963@2|Bacteria,1N1CG@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_168285_1 414684.RC1_2526 6.28e-20 86.7 2CUA5@1|root,32SUX@2|Bacteria,1RJP0@1224|Proteobacteria,2U9T0@28211|Alphaproteobacteria,2JUDB@204441|Rhodospirillales 204441|Rhodospirillales S Complex I intermediate-associated protein 30 (CIA30) - - - - - - - - - - - - CIA30 k59_69557_1 485913.Krac_6943 3.45e-13 68.6 COG1484@1|root,COG1484@2|Bacteria,2G7YG@200795|Chloroflexi 200795|Chloroflexi L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_69557_2 926550.CLDAP_12070 9.71e-36 135.0 COG4584@1|root,COG4584@2|Bacteria,2G808@200795|Chloroflexi 200795|Chloroflexi L Integrase core domain - - - - - - - - - - - - rve k59_70190_1 563040.Saut_1245 2.89e-37 129.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,430A1@68525|delta/epsilon subdivisions,2YSXA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT PAS domain - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - PAS_3 k59_70190_2 929558.SMGD1_0594 4.67e-43 149.0 COG3391@1|root,COG3391@2|Bacteria,1QUIK@1224|Proteobacteria,42RTQ@68525|delta/epsilon subdivisions,2YPA4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S amine dehydrogenase activity napL - - - - - - - - - - - - k59_854875_1 768066.HELO_1802 7.7e-57 198.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1XH7V@135619|Oceanospirillales 135619|Oceanospirillales CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_854875_2 118797.XP_007451335.1 1.89e-10 60.5 COG1003@1|root,KOG2040@2759|Eukaryota,38E0D@33154|Opisthokonta,3BBHH@33208|Metazoa,3CRRA@33213|Bilateria,48AQX@7711|Chordata,492SQ@7742|Vertebrata,3JFZ8@40674|Mammalia,4JB71@91561|Cetartiodactyla 33208|Metazoa E Glycine dehydrogenase (decarboxylating) - - - - - - - - - - - - GDC-P k59_985414_1 926561.KB900617_gene1320 4.47e-169 516.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3WBD0@53433|Halanaerobiales 186801|Clostridia E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_37174_1 1122951.ATUE01000005_gene1854 6.48e-25 107.0 COG2885@1|root,COG2885@2|Bacteria,1RC93@1224|Proteobacteria,1S2HJ@1236|Gammaproteobacteria,3NJM8@468|Moraxellaceae 1236|Gammaproteobacteria M Belongs to the ompA family omp - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA k59_265966_1 278957.ABEA03000046_gene1625 2.29e-108 325.0 COG3550@1|root,COG3550@2|Bacteria,46XT4@74201|Verrucomicrobia,3K8Y8@414999|Opitutae 414999|Opitutae S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_397253_1 994573.T472_0217800 7.84e-58 195.0 COG1785@1|root,COG1785@2|Bacteria,1TQCI@1239|Firmicutes,248GG@186801|Clostridia,36GQQ@31979|Clostridiaceae 186801|Clostridia P Belongs to the alkaline phosphatase family - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_789341_1 1123355.JHYO01000059_gene542 7.7e-57 188.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_32,rve,rve_3 k59_1018272_1 1492738.FEM21_03750 3.42e-101 312.0 COG3507@1|root,COG3507@2|Bacteria,4NH4M@976|Bacteroidetes,1IIJ6@117743|Flavobacteriia,2NYGR@237|Flavobacterium 976|Bacteroidetes G Glycosyl hydrolases family 32 N-terminal domain - - - - - - - - - - - - Glyco_hydro_43 k59_463159_1 1165841.SULAR_10619 1.02e-122 364.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2YMSH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c oxidase accessory protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_985417_1 1408439.JHXW01000009_gene344 4.87e-18 84.3 COG0793@1|root,COG0793@2|Bacteria,3786X@32066|Fusobacteria 32066|Fusobacteria M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_985417_2 469618.FVAG_00034 1.43e-115 335.0 COG0313@1|root,COG0313@2|Bacteria,378EN@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_985417_3 469618.FVAG_00035 3.33e-74 230.0 COG1161@1|root,COG1161@2|Bacteria,37846@32066|Fusobacteria 32066|Fusobacteria S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity ylqF - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 k59_822245_1 1537917.JU82_09960 2.36e-106 317.0 COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42RBN@68525|delta/epsilon subdivisions,2YP23@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the 'phage' integrase family - - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_691356_1 1049564.TevJSym_ap00510 9.74e-42 154.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341,ko:K05559 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_691356_2 90813.JQMT01000001_gene667 6.39e-20 89.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,4602R@72273|Thiotrichales 72273|Thiotrichales C NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_3353_1 1168034.FH5T_20165 1.73e-150 439.0 COG0845@1|root,COG0845@2|Bacteria,4NF6Y@976|Bacteroidetes,2FMZD@200643|Bacteroidia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_952772_1 485915.Dret_0022 3.58e-21 91.3 292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,42RFG@68525|delta/epsilon subdivisions,2WPKN@28221|Deltaproteobacteria,2ME7H@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF3047) - - - - - - - - - - - - DUF3047 k59_952772_2 1232410.KI421418_gene2422 6.92e-67 216.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,43VZ4@69541|Desulfuromonadales 28221|Deltaproteobacteria O SelR domain msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_952772_3 572544.Ilyop_0406 9.92e-100 293.0 COG0353@1|root,COG0353@2|Bacteria,378GZ@32066|Fusobacteria 32066|Fusobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_952772_6 572544.Ilyop_0441 1.68e-71 223.0 COG1489@1|root,COG1489@2|Bacteria,37918@32066|Fusobacteria 32066|Fusobacteria S Belongs to the SfsA family sfsA - - ko:K06206 - - - - ko00000 - - - SfsA k59_1018283_1 1469245.JFBG01000086_gene1622 1.61e-98 310.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_723915_2 990073.ATHU01000001_gene1586 3.66e-23 90.1 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,42WUA@68525|delta/epsilon subdivisions,2YQSD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H thiamine biosynthesis protein ThiS thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_103467_2 1335757.SPICUR_04615 9.93e-23 88.6 COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_103467_3 396588.Tgr7_1912 2.54e-77 242.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales 135613|Chromatiales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_985429_1 1165841.SULAR_07750 1.12e-126 365.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2YMQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_756245_1 1249627.D779_3094 1.67e-113 334.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1WXIF@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_103473_1 1168034.FH5T_06895 9.85e-58 189.0 COG0820@1|root,COG0820@2|Bacteria,4NFH5@976|Bacteroidetes,2FPJH@200643|Bacteroidia 976|Bacteroidetes J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_103473_2 1246626.BleG1_1842 3.08e-30 119.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,4H9SZ@91061|Bacilli,1ZAX7@1386|Bacillus 91061|Bacilli E Sodium alanine symporter agcS - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_756246_1 572544.Ilyop_0384 5.51e-27 111.0 COG0577@1|root,COG0577@2|Bacteria,37A3F@32066|Fusobacteria 32066|Fusobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_298742_1 1313172.YM304_12510 3.73e-31 119.0 COG1028@1|root,COG1028@2|Bacteria,2GKVM@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_265984_1 292415.Tbd_0887 1.54e-125 369.0 COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2WGMS@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the peptidase S33 family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_952782_1 1125863.JAFN01000001_gene3206 1.11e-94 292.0 COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_103475_2 1193181.BN10_1070017 1.05e-14 75.1 COG2885@1|root,COG2885@2|Bacteria,2HJR6@201174|Actinobacteria,4FHS4@85021|Intrasporangiaceae 201174|Actinobacteria M OmpA family - - - - - - - - - - - - OmpA k59_528419_1 526227.Mesil_1505 7.53e-85 266.0 COG0334@1|root,COG0334@2|Bacteria,1WIVE@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_332181_1 104623.Ser39006_03293 1.61e-45 161.0 COG3711@1|root,COG3711@2|Bacteria,1NHN8@1224|Proteobacteria,1RR9W@1236|Gammaproteobacteria,401SI@613|Serratia 1236|Gammaproteobacteria K antiterminator - - - ko:K03488 - - - - ko00000,ko03000 - - - CAT_RBD,PRD k59_332181_2 1329516.JPST01000047_gene2805 1e-11 66.6 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1TP5X@1239|Firmicutes,4HA0I@91061|Bacilli,27CIB@186824|Thermoactinomycetaceae 91061|Bacilli G phosphotransferase system, EIIB treP GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015766,GO:0015771,GO:0015772,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090589 2.7.1.201 ko:K02818,ko:K02819 ko00500,ko02060,map00500,map02060 M00270 R02780 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.13,4.A.1.2.4,4.A.1.2.8 - iYO844.BSU07800 PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_332181_3 1408439.JHXW01000012_gene895 4.11e-28 103.0 COG1925@1|root,COG1925@2|Bacteria,37AJV@32066|Fusobacteria 32066|Fusobacteria G phosphocarrier protein ptsH - - ko:K02784,ko:K11189 ko02060,map02060 - - - ko00000,ko00001,ko02000 4.A.2.1,8.A.8.1.1 - - PTS-HPr k59_332181_4 469616.FMAG_00763 1e-264 742.0 COG1080@1|root,COG1080@2|Bacteria,378UT@32066|Fusobacteria 32066|Fusobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsP - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_332181_5 1120998.AUFC01000034_gene1356 5.45e-149 436.0 COG1448@1|root,COG1448@2|Bacteria,1TRJV@1239|Firmicutes,24BZV@186801|Clostridia 186801|Clostridia E Aminotransferase, class I II - - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_332181_6 1319815.HMPREF0202_01597 4.29e-28 121.0 COG2801@1|root,COG2801@2|Bacteria,379U2@32066|Fusobacteria 32066|Fusobacteria L Mu transposase, C-terminal - - - ko:K07497 - - - - ko00000 - - - HTH_28,Mu-transpos_C k59_332181_7 1408439.JHXW01000012_gene843 6.94e-53 172.0 COG2190@1|root,COG2190@2|Bacteria,37A1G@32066|Fusobacteria 32066|Fusobacteria G PTS system crr - - ko:K02777 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1 - - PTS_EIIA_1 k59_332181_8 469618.FVAG_01004 1.44e-251 702.0 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,378A5@32066|Fusobacteria 32066|Fusobacteria G PTS system ptsG - 2.7.1.199 ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00809 R02738 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.9 - - PTS_EIIB,PTS_EIIC k59_332181_9 1410653.JHVC01000006_gene222 5.59e-134 400.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,36DJD@31979|Clostridiaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE k59_723929_1 1128427.KB904821_gene4512 6.13e-48 155.0 arCOG12631@1|root,3172B@2|Bacteria,1G8HJ@1117|Cyanobacteria,1HCKT@1150|Oscillatoriales 1117|Cyanobacteria S Bacterial PH domain - - - - - - - - - - - - bPH_1 k59_3370_1 292415.Tbd_0828 1.3e-94 303.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1KS3D@119069|Hydrogenophilales 28216|Betaproteobacteria L Bacterial DNA polymerase III alpha subunit - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_659196_1 585543.HMPREF0969_00608 4.26e-13 77.8 2A6YS@1|root,30VTS@2|Bacteria,4NZDT@976|Bacteroidetes 976|Bacteroidetes S EpsG family - - - - - - - - - - - - EpsG k59_659196_2 1123288.SOV_3c03470 2.28e-38 151.0 COG3562@1|root,COG3562@2|Bacteria,1VAY8@1239|Firmicutes 1239|Firmicutes M Capsule polysaccharide biosynthesis protein - - - - - - - - - - - - Capsule_synth k59_659196_3 86416.Clopa_0850 1.27e-89 288.0 COG2244@1|root,COG2244@2|Bacteria,1TR7A@1239|Firmicutes,24C7V@186801|Clostridia 186801|Clostridia S membrane protein involved in the export of O-antigen and teichoic acid - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C k59_200880_1 111781.Lepto7376_0248 1.99e-85 259.0 COG3541@1|root,COG3541@2|Bacteria,1G3R1@1117|Cyanobacteria,1H74A@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Nucleotidyltransferase - - - ko:K07074 - - - - ko00000 - - - Nuc-transf k59_200880_2 338966.Ppro_2636 2.86e-10 63.9 COG3637@1|root,COG3637@2|Bacteria,1NGKR@1224|Proteobacteria,42XMD@68525|delta/epsilon subdivisions,2WSIW@28221|Deltaproteobacteria,43UMH@69541|Desulfuromonadales 28221|Deltaproteobacteria M Surface antigen - - - - - - - - - - - - OMP_b-brl k59_200880_4 207954.MED92_15203 2.4e-219 649.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XI40@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - 5TM-5TMR_LYT,EAL,GGDEF,PAS_9 k59_200880_5 2340.JV46_06040 7.9e-140 409.0 COG3287@1|root,COG3287@2|Bacteria,1R825@1224|Proteobacteria,1S25E@1236|Gammaproteobacteria,1JAHR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S FIST_C - - - - - - - - - - - - FIST,FIST_C k59_8140_1 1056512.D515_01969 1.17e-06 48.9 29FB6@1|root,3028V@2|Bacteria,1QKAI@1224|Proteobacteria,1TIE2@1236|Gammaproteobacteria,1XYYI@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_862063_2 387093.SUN_2370 8.44e-05 45.4 COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42MDF@68525|delta/epsilon subdivisions,2YMNI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Pseudouridine synthase sfhB - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_177110_1 926549.KI421517_gene1934 2.26e-85 263.0 2DMY6@1|root,32UCD@2|Bacteria,4NVHX@976|Bacteroidetes,47SQF@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_568884_1 1168034.FH5T_06135 6.51e-137 404.0 COG2956@1|root,COG2956@2|Bacteria,4PNWA@976|Bacteroidetes,2G0ZI@200643|Bacteroidia 976|Bacteroidetes G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane - - - - - - - - - - - - TPR_16 k59_993944_1 1114856.C496_03698 9.41e-25 103.0 COG1028@1|root,arCOG01259@2157|Archaea,2XW9M@28890|Euryarchaeota,23SCP@183963|Halobacteria 183963|Halobacteria I COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_241428_1 1122973.KB904289_gene791 2.78e-56 184.0 COG1148@1|root,COG2878@1|root,COG1148@2|Bacteria,COG2878@2|Bacteria,4NFEB@976|Bacteroidetes,2FMPN@200643|Bacteroidia,22XEE@171551|Porphyromonadaceae 976|Bacteroidetes C Ferredoxin rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_241428_2 1168034.FH5T_16600 1.57e-57 190.0 COG4656@1|root,COG4656@2|Bacteria,4NIS7@976|Bacteroidetes,2FMAQ@200643|Bacteroidia 976|Bacteroidetes C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,Fer4_7,RnfC_N,SLBB k59_928767_1 1278309.KB907103_gene1012 5.74e-30 122.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XITW@135619|Oceanospirillales 135619|Oceanospirillales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_272894_1 882.DVU_2824 7.84e-112 345.0 COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2M9FS@213115|Desulfovibrionales 28221|Deltaproteobacteria C Glycine radical - - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_895481_1 1408473.JHXO01000006_gene1077 1.82e-28 113.0 2CD20@1|root,2Z7SQ@2|Bacteria,4NEQ1@976|Bacteroidetes,2FWPF@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_895481_2 1168034.FH5T_12530 5.35e-28 112.0 COG0305@1|root,COG0305@2|Bacteria,4NF8P@976|Bacteroidetes,2FNG7@200643|Bacteroidia 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_928770_1 1168034.FH5T_12195 3.02e-104 325.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,4NEHE@976|Bacteroidetes,2FM8K@200643|Bacteroidia 976|Bacteroidetes G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_993951_1 1168034.FH5T_21760 1.52e-144 410.0 COG2820@1|root,COG2820@2|Bacteria,4NESQ@976|Bacteroidetes,2FP2V@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile amn - 3.2.2.4 ko:K01241 ko00230,map00230 - R00182 RC00063,RC00318 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_601774_1 1168289.AJKI01000063_gene3488 4.31e-75 237.0 COG0739@1|root,COG0739@2|Bacteria,4NFZN@976|Bacteroidetes,2FMIQ@200643|Bacteroidia,3XJWX@558415|Marinilabiliaceae 976|Bacteroidetes M Peptidase family M23 nlpD_1 - - - - - - - - - - - Peptidase_M23 k59_43843_1 536233.CLO_2559 2.4e-22 94.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,36JJ4@31979|Clostridiaceae 186801|Clostridia J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_43843_3 1121946.AUAX01000038_gene2635 7.28e-05 45.8 COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4D8KE@85008|Micromonosporales 201174|Actinobacteria J Responsible for synthesis of pseudouridine from uracil rluD GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_209608_1 177437.HRM2_11010 4.42e-39 140.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,42S1V@68525|delta/epsilon subdivisions,2WNDR@28221|Deltaproteobacteria,2MJVB@213118|Desulfobacterales 28221|Deltaproteobacteria NU PFAM Pilus assembly protein PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_794361_1 1049564.TevJSym_bk00240 2.69e-109 326.0 COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1JAVX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G pfkB family carbohydrate kinase - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_536750_1 472759.Nhal_3499 3.83e-23 91.3 COG0724@1|root,COG0724@2|Bacteria,1NDEM@1224|Proteobacteria,1SFDX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM RNA recognition motif - - - - - - - - - - - - RRM_1 k59_536750_2 1137799.GZ78_09705 4.4e-20 81.6 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XM5A@135619|Oceanospirillales 135619|Oceanospirillales K cold-shock protein cspG - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_341020_1 1038867.AXAY01000020_gene3397 3.31e-47 165.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria,3JSRI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P NMT1-like family MA20_13115 - - ko:K15576,ko:K22067 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000,ko02022 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_144818_1 395494.Galf_1572 6.92e-102 306.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_504448_2 1250232.JQNJ01000001_gene3327 2.59e-53 176.0 COG3023@1|root,COG3023@2|Bacteria,4NMIV@976|Bacteroidetes,1HY6G@117743|Flavobacteriia 976|Bacteroidetes V N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_470051_1 56780.SYN_01022 4.53e-74 234.0 COG1234@1|root,COG1234@2|Bacteria 2|Bacteria L tRNA 3'-trailer cleavage - - - - - - - - - - - - Lactamase_B_2 k59_470051_2 572544.Ilyop_0827 2.84e-47 152.0 COG3123@1|root,COG3123@2|Bacteria 2|Bacteria S guanosine phosphorylase activity ppnP GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.1,2.4.2.2 ko:K09913 ko00230,ko00240,map00230,map00240 - R01561,R01570,R01863,R01876,R02147,R02296,R02297 RC00063,RC00122 ko00000,ko00001,ko01000 - - - DUF1255 k59_470051_3 1170562.Cal6303_3441 3.23e-19 92.0 COG0412@1|root,COG0412@2|Bacteria,1G0PH@1117|Cyanobacteria 1117|Cyanobacteria Q dienelactone hydrolase clcD - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_730966_1 72664.XP_006393559.1 2.71e-37 128.0 COG0049@1|root,KOG3291@2759|Eukaryota,37JZ5@33090|Viridiplantae,3GGCG@35493|Streptophyta 35493|Streptophyta J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit rps7 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006996,GO:0008150,GO:0009507,GO:0009536,GO:0009579,GO:0009987,GO:0016020,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_504453_1 1384054.N790_02690 5.99e-97 290.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1X38C@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_404793_1 857087.Metme_2625 2.35e-86 266.0 COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1XECA@135618|Methylococcales 135618|Methylococcales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF - 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_536764_1 1121895.Q765_04530 3.49e-10 62.0 COG1131@1|root,COG1131@2|Bacteria,4NFNM@976|Bacteroidetes,1I1AY@117743|Flavobacteriia,2NT7W@237|Flavobacterium 976|Bacteroidetes V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K20459 ko02010,map02010 M00813 - - ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 - - ABC_tran k59_536764_2 754477.Q7C_582 1.67e-16 80.5 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4607S@72273|Thiotrichales 72273|Thiotrichales T nitrogen regulation protein NR(I) - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_634505_1 59689.scaffold_201036.1 1.51e-55 177.0 COG0522@1|root,KOG3301@2759|Eukaryota,37TGK@33090|Viridiplantae,3G7BN@35493|Streptophyta 35493|Streptophyta J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rps4 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_960598_1 742735.HMPREF9467_00539 1.79e-21 93.2 COG2227@1|root,COG2227@2|Bacteria,1UXZZ@1239|Firmicutes,24BIT@186801|Clostridia,21XYV@1506553|Lachnoclostridium 186801|Clostridia H Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25 k59_272922_1 1168034.FH5T_02980 4.24e-06 48.1 COG0727@1|root,COG0727@2|Bacteria,4NQPE@976|Bacteroidetes,2FY2E@200643|Bacteroidia 976|Bacteroidetes S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC k59_272922_2 1168034.FH5T_02975 4.64e-114 339.0 COG1115@1|root,COG1115@2|Bacteria,4NDX7@976|Bacteroidetes,2FMFZ@200643|Bacteroidia 976|Bacteroidetes E amino acid carrier protein - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_78267_1 666685.R2APBS1_1035 1.37e-14 73.2 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1X3KG@135614|Xanthomonadales 135614|Xanthomonadales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_78267_2 243233.MCA2447 9.58e-43 158.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1XDRZ@135618|Methylococcales 135618|Methylococcales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_241472_1 1168034.FH5T_18800 1.4e-91 296.0 28HY3@1|root,2Z83I@2|Bacteria,4NHFN@976|Bacteroidetes,2FX5V@200643|Bacteroidia 976|Bacteroidetes S phosphoenolpyruvate carboxykinase (diphosphate) activity - - - - - - - - - - - - - k59_862112_1 388413.ALPR1_19473 1.62e-91 280.0 COG0148@1|root,COG0148@2|Bacteria,4NF5M@976|Bacteroidetes,47MI4@768503|Cytophagia 976|Bacteroidetes G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_436954_1 1537917.JU82_04685 2.02e-96 283.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2YP49@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidyl-prolyl cis-trans isomerase slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_568924_1 269799.Gmet_3395 3.49e-154 446.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,43TF1@69541|Desulfuromonadales 28221|Deltaproteobacteria C belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3395 Aldedh k59_994002_1 1168034.FH5T_21255 7.32e-98 302.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,4NFCF@976|Bacteroidetes,2FW8B@200643|Bacteroidia 976|Bacteroidetes P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_994007_1 563040.Saut_0044 1.48e-62 202.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,42MYW@68525|delta/epsilon subdivisions,2YN5Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_994007_2 1121011.AUCB01000002_gene437 7.24e-32 115.0 COG3189@1|root,COG3189@2|Bacteria,4NSFD@976|Bacteroidetes,1I42N@117743|Flavobacteriia,23IBV@178469|Arenibacter 976|Bacteroidetes S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 k59_436974_1 1042377.AFPJ01000036_gene1260 2.54e-60 204.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,464MC@72275|Alteromonadaceae 1236|Gammaproteobacteria S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_895553_1 1121115.AXVN01000074_gene2302 7.12e-32 127.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,3XZQC@572511|Blautia 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_994008_1 366649.XFF4834R_chr10660 9.59e-59 208.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1X4BU@135614|Xanthomonadales 135614|Xanthomonadales O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_1025531_1 384676.PSEEN5270 1.16e-25 108.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_764348_1 631362.Thi970DRAFT_00084 4.94e-83 259.0 COG4974@1|root,COG4974@2|Bacteria,1QV9T@1224|Proteobacteria,1T2UQ@1236|Gammaproteobacteria,1X2TS@135613|Chromatiales 135613|Chromatiales L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_764348_2 686340.Metal_4000 1.26e-24 97.4 2E5K5@1|root,330BC@2|Bacteria,1N428@1224|Proteobacteria,1SAVR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Siphovirus Gp157 - - - - - - - - - - - - Sipho_Gp157 k59_829982_1 1123326.JFBL01000007_gene639 3.05e-15 74.7 COG0189@1|root,COG0189@2|Bacteria,1R4ZF@1224|Proteobacteria,42PG3@68525|delta/epsilon subdivisions,2YMQ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_829982_2 929558.SMGD1_0766 6.92e-78 244.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,42NNZ@68525|delta/epsilon subdivisions,2YNIC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Peptidase dimerisation domain - - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_78297_1 1049564.TevJSym_ad00270 1.06e-80 255.0 COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,1S0HQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C overlaps another CDS with the same product name - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_272955_1 1168034.FH5T_12725 1.93e-09 57.0 COG0451@1|root,COG0451@2|Bacteria,4NMWC@976|Bacteroidetes 976|Bacteroidetes GM epimerase yeeZ - - - - - - - - - - - Epimerase,NAD_binding_10,NAD_binding_2 k59_862696_1 558169.AGAV01000007_gene1379 8.31e-23 102.0 COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,4H9SU@91061|Bacilli 91061|Bacilli T Carbon starvation protein cstA_1 - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_373195_1 1537917.JU82_04795 1.83e-223 641.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2YMIZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_569445_2 1265505.ATUG01000001_gene2854 6.54e-66 203.0 COG2204@1|root,COG2204@2|Bacteria,1MYSD@1224|Proteobacteria,42SVG@68525|delta/epsilon subdivisions,2WPRW@28221|Deltaproteobacteria,2MK6T@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_210305_1 1356852.N008_01120 4.97e-20 89.7 COG1595@1|root,COG1595@2|Bacteria,4NQCH@976|Bacteroidetes,47XG5@768503|Cytophagia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_341662_1 261292.Nit79A3_0953 3.26e-110 335.0 COG3039@1|root,COG3039@2|Bacteria,1R6NB@1224|Proteobacteria,2W14S@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - - k59_44426_1 314278.NB231_10753 6.01e-75 233.0 COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1S296@1236|Gammaproteobacteria,1X2D7@135613|Chromatiales 135613|Chromatiales L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_602501_1 1122134.KB893650_gene1333 1.33e-49 169.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,1RNEJ@1236|Gammaproteobacteria,1XPI5@135619|Oceanospirillales 135619|Oceanospirillales G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_699851_1 998674.ATTE01000001_gene2010 7.08e-33 127.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,460FY@72273|Thiotrichales 72273|Thiotrichales M PFAM Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_929435_1 889378.Spiaf_2703 1.05e-86 270.0 COG0372@1|root,COG0372@2|Bacteria,2J571@203691|Spirochaetes 203691|Spirochaetes C citrate synthase - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_273480_1 555500.I215_15638 1e-79 249.0 COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,1HZYN@117743|Flavobacteriia 976|Bacteroidetes L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_405393_1 1283300.ATXB01000002_gene2886 8.9e-31 125.0 COG3637@1|root,COG3637@2|Bacteria,1R42W@1224|Proteobacteria,1RYPE@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Putative outer membrane beta-barrel porin, MtrB/PioB - - - - - - - - - - - - MtrB_PioB k59_210314_1 1537917.JU82_04805 9.25e-191 540.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2YMZK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_210314_2 1249480.B649_08155 1.39e-30 118.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2YMS3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_177862_1 765912.Thimo_3319 7.33e-144 428.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_44441_1 335543.Sfum_0615 6.17e-78 253.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,42NQY@68525|delta/epsilon subdivisions,2WISG@28221|Deltaproteobacteria,2MQ4V@213462|Syntrophobacterales 28221|Deltaproteobacteria HP TIGRFAM molybdenum cofactor synthesis domain - - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_794793_1 1417296.U879_04020 8.1e-39 137.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria 1224|Proteobacteria V non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_505194_1 1355374.JARU01000001_gene149 2.47e-110 328.0 COG3344@1|root,COG3344@2|Bacteria 2|Bacteria L reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - RVT_1 k59_830568_1 1123392.AQWL01000002_gene1819 1.33e-27 114.0 COG2262@1|root,COG2262@2|Bacteria,1QV04@1224|Proteobacteria,2WGNW@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF3482) - - - - - - - - - - - - DUF3482,MMR_HSR1 k59_830568_2 598467.BrE312_1474 7.02e-05 46.2 COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,1RMX9@1236|Gammaproteobacteria 1236|Gammaproteobacteria I the in vivo substrate is - - - - - - - - - - - - DAGK_cat k59_437586_1 665029.EAMY_3683 1.02e-69 228.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,3X4GW@551|Erwinia 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_934267_1 1537917.JU82_00255 5.92e-103 313.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2YN5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_934267_2 387092.NIS_0171 2.23e-58 187.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2YNU1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_673306_1 1121335.Clst_2612 0.000163 49.3 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,3WRQU@541000|Ruminococcaceae 186801|Clostridia H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_966472_2 1168034.FH5T_14070 1.57e-234 655.0 COG1530@1|root,COG1530@2|Bacteria,4NED1@976|Bacteroidetes,2FMXV@200643|Bacteroidia 976|Bacteroidetes J S1 RNA binding domain protein rng - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1031119_1 1123073.KB899242_gene997 7.01e-62 203.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1X361@135614|Xanthomonadales 135614|Xanthomonadales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_7 k59_835626_1 1123401.JHYQ01000008_gene417 7.25e-17 79.7 COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,460DZ@72273|Thiotrichales 72273|Thiotrichales G pfkB family carbohydrate kinase - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_346845_2 391615.ABSJ01000050_gene1234 4.24e-43 152.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminotransferase - - - - - - - - - - - - Aminotran_5 k59_442545_1 589865.DaAHT2_0294 1.2e-33 129.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2MIGY@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_510883_1 1173024.KI912152_gene637 8.27e-05 43.5 COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_411040_1 395019.Bmul_1250 1.22e-92 301.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1K119@119060|Burkholderiaceae 28216|Betaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_117374_1 1120949.KB903294_gene3923 2.55e-13 77.0 COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria,4DHSA@85008|Micromonosporales 201174|Actinobacteria S Phage tail sheath C-terminal domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_84317_1 1357399.HMPREF2087_01405 1.31e-46 153.0 COG5611@1|root,COG5611@2|Bacteria,1NDBN@1224|Proteobacteria,42VV9@68525|delta/epsilon subdivisions,2YQ7Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_84317_3 754331.AEME01000001_gene834 9.49e-11 61.2 COG3738@1|root,COG3738@2|Bacteria,1RE1M@1224|Proteobacteria,1S44B@1236|Gammaproteobacteria,3XN1E@561|Escherichia 1236|Gammaproteobacteria S Domain of unknown function (DUF1287) yijF - - ko:K09974 - - - - ko00000 - - - DUF1287 k59_542772_1 1415778.JQMM01000001_gene1962 1.35e-06 55.5 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1J5ES@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M UTP--glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_608142_1 1122925.KB895377_gene1044 1.09e-13 80.1 COG2211@1|root,COG2211@2|Bacteria,1UIHN@1239|Firmicutes,4ISIJ@91061|Bacilli,2773I@186822|Paenibacillaceae 91061|Bacilli G Nucleoside H+ symporter - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_278922_1 373994.Riv7116_2717 6.13e-24 108.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GRE7@1117|Cyanobacteria,1HRR4@1161|Nostocales 1117|Cyanobacteria KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_183644_1 765912.Thimo_3667 2.56e-68 219.0 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1WW2I@135613|Chromatiales 135613|Chromatiales HL Thiamine monophosphate synthase - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,NUDIX_4,TMP-TENI k59_411049_1 1408473.JHXO01000007_gene943 1.8e-62 212.0 COG0339@1|root,COG0339@2|Bacteria,4NFYA@976|Bacteroidetes,2FNQV@200643|Bacteroidia 976|Bacteroidetes E Peptidase family M3 dcp - 3.4.15.5 ko:K01284 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_1031694_1 574966.KB898648_gene682 1.71e-16 73.9 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XKBF@135619|Oceanospirillales 135619|Oceanospirillales K Belongs to the P(II) protein family - - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_1031694_2 472759.Nhal_0413 8.99e-05 48.1 2DR2Y@1|root,339YA@2|Bacteria,1NHB7@1224|Proteobacteria,1SH0X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_247810_1 326298.Suden_1059 3.88e-15 74.3 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42NHA@68525|delta/epsilon subdivisions,2YMYU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX1 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_247810_2 1537917.JU82_08235 1.97e-42 140.0 COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2YQ8B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_542779_1 411684.HPDFL43_18072 7.57e-31 118.0 COG1116@1|root,COG1116@2|Bacteria,1N7FP@1224|Proteobacteria,2U0JY@28211|Alphaproteobacteria,43K2R@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran k59_1031695_1 29581.BW37_05204 9.25e-17 79.3 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,473F1@75682|Oxalobacteraceae 28216|Betaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1031695_2 697282.Mettu_3543 9.07e-43 148.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1XF3T@135618|Methylococcales 135618|Methylococcales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_13928_2 439235.Dalk_1118 9.71e-21 93.6 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2WJZR@28221|Deltaproteobacteria,2MIY9@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM peptidase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_640755_1 649638.Trad_2591 2.29e-48 181.0 COG0539@1|root,COG0539@2|Bacteria,1WJGM@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J Ribosomal protein S1 rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_640755_2 572544.Ilyop_1735 1.17e-63 204.0 COG0761@1|root,COG0761@2|Bacteria,3789B@32066|Fusobacteria 32066|Fusobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_705640_1 469617.FUAG_00054 1.95e-125 372.0 COG1301@1|root,COG1301@2|Bacteria,378TK@32066|Fusobacteria 32066|Fusobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_84341_1 626887.J057_15260 1.46e-30 117.0 COG3637@1|root,COG3637@2|Bacteria,1RHVI@1224|Proteobacteria,1S6UY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M OmpA-like transmembrane domain - - - - - - - - - - - - OMP_b-brl,OmpA_membrane k59_673881_1 690850.Desaf_2364 1.48e-57 196.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1031700_1 1041522.MCOL_V204885 3.89e-10 65.9 COG2141@1|root,COG2141@2|Bacteria,2GMUP@201174|Actinobacteria,234CU@1762|Mycobacteriaceae 201174|Actinobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1031700_2 1172190.M947_04980 7.65e-60 206.0 COG1629@1|root,COG4771@2|Bacteria,1MXY7@1224|Proteobacteria,42MSN@68525|delta/epsilon subdivisions,2YN7D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_868435_1 1089439.KB902240_gene806 3.15e-53 184.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,45ZQY@72273|Thiotrichales 72273|Thiotrichales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_312411_1 1056820.KB900685_gene2794 5.06e-05 46.6 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,2PNDQ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Inositol monophosphatase family cysQ GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - iAPECO1_1312.APECO1_2172,iE2348C_1286.E2348C_4545,iEC042_1314.EC042_4695,iEC55989_1330.EC55989_4774,iECABU_c1320.ECABU_c47840,iECIAI1_1343.ECIAI1_4448,iECIAI39_1322.ECIAI39_4686,iECO103_1326.ECO103_5013,iECO111_1330.ECO111_5101,iECO26_1355.ECO26_5384,iECOK1_1307.ECOK1_4735,iECP_1309.ECP_4468,iECSE_1348.ECSE_4520,iECSF_1327.ECSF_4108,iECUMN_1333.ECUMN_4751,iECW_1372.ECW_m4578,iEKO11_1354.EKO11_4094,iEcE24377_1341.EcE24377A_4785,iEcHS_1320.EcHS_A4468,iEcSMS35_1347.EcSMS35_4694,iLF82_1304.LF82_0422,iNRG857_1313.NRG857_21455,iSBO_1134.SBO_4229,iSDY_1059.SDY_4385,iSSON_1240.SSON_4399,iSbBS512_1146.SbBS512_E4758,iUMN146_1321.UM146_21355,iUTI89_1310.UTI89_C4823,iWFL_1372.ECW_m4578,ic_1306.c5313 Inositol_P k59_312411_2 1415778.JQMM01000001_gene122 1.13e-26 104.0 COG0546@1|root,COG0546@2|Bacteria,1QUHZ@1224|Proteobacteria,1T1ZN@1236|Gammaproteobacteria,1JC2Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Haloacid dehalogenase-like hydrolase - - 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_49879_1 1168034.FH5T_11085 3.82e-73 243.0 COG0525@1|root,COG0525@2|Bacteria,4NETB@976|Bacteroidetes,2FPJG@200643|Bacteroidia 976|Bacteroidetes J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_967155_1 1165841.SULAR_02068 5.4e-52 175.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2YNC5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_967155_2 1165841.SULAR_02073 4.08e-89 272.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2YNS0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_967155_3 1238182.C882_1744 4.95e-16 75.1 COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,2U10V@28211|Alphaproteobacteria,2JRBZ@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the SfsA family sfsA - - ko:K06206 - - - - ko00000 - - - SfsA k59_49883_1 1300350.DSW25_12440 3.52e-38 148.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3ZWIQ@60136|Sulfitobacter 28211|Alphaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1031722_1 1168034.FH5T_05490 4.57e-104 317.0 COG0481@1|root,COG0481@2|Bacteria,4NEJ9@976|Bacteroidetes,2FM9V@200643|Bacteroidia 976|Bacteroidetes M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_49884_1 1121396.KB893104_gene1782 2.76e-114 335.0 COG3464@1|root,COG3464@2|Bacteria,1Q4UF@1224|Proteobacteria,42ZWR@68525|delta/epsilon subdivisions,2WV9E@28221|Deltaproteobacteria,2MNHQ@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_575221_1 1380350.JIAP01000011_gene6368 1.29e-14 79.3 COG3188@1|root,COG3188@2|Bacteria,1MWV6@1224|Proteobacteria,2TU95@28211|Alphaproteobacteria,43MMM@69277|Phyllobacteriaceae 28211|Alphaproteobacteria NU P pilus assembly protein porin PapC - - - ko:K07347 ko05133,map05133 - - - ko00000,ko00001,ko02000,ko02035,ko02044 1.B.11.3 - - PapC_C,Usher k59_247837_1 742821.HMPREF9464_02355 1.12e-07 57.4 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2VJYH@28216|Betaproteobacteria,4PRPJ@995019|Sutterellaceae 28216|Betaproteobacteria C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_binding_2 k59_510938_1 709032.Sulku_0010 1.97e-38 142.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ7@1224|Proteobacteria,43BJF@68525|delta/epsilon subdivisions,2YNM7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,sCache_like k59_183676_1 1165841.SULAR_06318 2.88e-87 286.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2YMJS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,NIT,Response_reg k59_967157_1 314256.OG2516_14975 1.92e-11 66.6 COG2244@1|root,COG2244@2|Bacteria,1MUN5@1224|Proteobacteria,2UC72@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C k59_967157_2 452637.Oter_0895 6.71e-151 436.0 COG0493@1|root,COG0493@2|Bacteria,46T1M@74201|Verrucomicrobia,3K775@414999|Opitutae 414999|Opitutae E TIGRFAM glutamate synthase, NADH NADPH, small subunit - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_800163_2 1469245.JFBG01000056_gene2481 1.73e-25 99.4 COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria,1WYSI@135613|Chromatiales 135613|Chromatiales C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C,Cytochrome_CBB3 k59_278968_1 1163617.SCD_n02351 2.49e-50 172.0 COG1819@1|root,COG1819@2|Bacteria,1MVJM@1224|Proteobacteria,2VME8@28216|Betaproteobacteria 28216|Betaproteobacteria CG glycosyl - - - - - - - - - - - - - k59_542808_1 1094715.CM001373_gene671 1.78e-164 487.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1JCU0@118969|Legionellales 118969|Legionellales H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_312431_1 935836.JAEL01000008_gene3917 2.15e-42 145.0 COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,4HAMW@91061|Bacilli,1ZC4X@1386|Bacillus 91061|Bacilli IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) kduD - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short,adh_short_C2 k59_312431_2 469616.FMAG_01330 2.19e-36 135.0 COG0412@1|root,COG0412@2|Bacteria 2|Bacteria Q carboxymethylenebutenolidase activity - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - Abhydrolase_7,DLH,Peptidase_S9 k59_967164_1 1280001.BAOA01000138_gene1983 4.79e-59 199.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1XWE9@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_868459_1 1168034.FH5T_20355 6.3e-85 273.0 COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes 976|Bacteroidetes E Aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_1000196_1 1121004.ATVC01000042_gene944 5.4e-103 328.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KPEV@206351|Neisseriales 206351|Neisseriales V Efflux pump membrane transporter mtrD - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_901617_1 709032.Sulku_1796 4.02e-20 87.0 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2YPC4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_901617_2 572544.Ilyop_1676 5.64e-54 175.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase yycN - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_901617_3 572544.Ilyop_1677 0.0 952.0 COG0443@1|root,COG0443@2|Bacteria,378AS@32066|Fusobacteria 32066|Fusobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_901617_4 572544.Ilyop_1678 6.31e-68 211.0 COG0576@1|root,COG0576@2|Bacteria,37A65@32066|Fusobacteria 32066|Fusobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_967165_1 396588.Tgr7_2770 1.08e-63 197.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1WXZT@135613|Chromatiales 135613|Chromatiales S EVE domain - - - - - - - - - - - - EVE k59_216224_1 1168034.FH5T_06735 2.21e-94 280.0 COG0164@1|root,COG0164@2|Bacteria,4NGVR@976|Bacteroidetes,2FMS7@200643|Bacteroidia 976|Bacteroidetes L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_411094_1 1227488.C477_10308 4.63e-15 73.9 arCOG01670@1|root,arCOG01670@2157|Archaea,2XXSI@28890|Euryarchaeota,23WI1@183963|Halobacteria 183963|Halobacteria S DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_411094_2 1288963.ADIS_4786 8.6e-07 49.7 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,47KYI@768503|Cytophagia 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_800172_1 631362.Thi970DRAFT_04920 1.86e-92 286.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,1RYHK@1236|Gammaproteobacteria,1WXMQ@135613|Chromatiales 135613|Chromatiales C PFAM Radical SAM - - - - - - - - - - - - Radical_SAM k59_476323_1 1168034.FH5T_00370 9.13e-110 327.0 COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes,2FN8H@200643|Bacteroidia 976|Bacteroidetes J SAM-dependent methyltransferase rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_151076_1 930169.B5T_01767 9.97e-57 191.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RTDH@1236|Gammaproteobacteria,1XQQP@135619|Oceanospirillales 135619|Oceanospirillales L Transposase - - - - - - - - - - - - - k59_378760_1 713587.THITH_10065 3.17e-108 323.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_575251_1 400668.Mmwyl1_1672 4.15e-20 94.4 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria 1224|Proteobacteria U 6-phosphogluconolactonase activity - - - - - - - - - - - - Cadherin,DUF4347,Haemagg_act,He_PIG,Hint_2,TIG k59_151080_1 1123229.AUBC01000003_gene1942 9.57e-24 104.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2TV6G@28211|Alphaproteobacteria,3JR7Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O symbiont process - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_868467_1 572544.Ilyop_2842 7.61e-71 221.0 2EGNU@1|root,33AEZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_868467_2 572544.Ilyop_2843 8.97e-134 394.0 COG0471@1|root,COG0471@2|Bacteria 2|Bacteria P metal ion transport - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_183709_1 1168034.FH5T_05355 2.33e-30 122.0 COG1629@1|root,COG4771@2|Bacteria,4NFZY@976|Bacteroidetes 976|Bacteroidetes P Outer membrane receptor - - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec k59_14004_1 641107.CDLVIII_3193 7.43e-90 286.0 2ARXV@1|root,31H9T@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - SIR2_2 k59_800187_1 926569.ANT_29640 3.68e-74 233.0 COG0407@1|root,COG0407@2|Bacteria 2|Bacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_216244_1 768671.ThimaDRAFT_3828 4.48e-102 329.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales 135613|Chromatiales C pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_151092_1 1411685.U062_00077 5.1e-82 264.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1J8QD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C HI0933-like protein fadH - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_443267_1 690850.Desaf_3012 0.000102 45.8 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,42N5X@68525|delta/epsilon subdivisions,2WJ3H@28221|Deltaproteobacteria,2M8IH@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM permease YjgP YjgQ family protein lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1006423_2 1265505.ATUG01000002_gene2391 8.12e-85 254.0 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MI9D@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 k59_157949_1 1123504.JQKD01000018_gene2036 2.48e-05 49.7 COG1075@1|root,COG1075@2|Bacteria,1MWM9@1224|Proteobacteria,2VN20@28216|Betaproteobacteria,4ACT5@80864|Comamonadaceae 28216|Betaproteobacteria S Lipase (class 2) - - - - - - - - - - - - Lipase_2 k59_549484_2 1380390.JIAT01000009_gene1989 4.93e-18 82.4 COG1280@1|root,COG1280@2|Bacteria,2INXA@201174|Actinobacteria 201174|Actinobacteria E LysE type translocator - - - - - - - - - - - - LysE k59_417049_1 1168034.FH5T_02630 1.89e-67 224.0 COG0471@1|root,COG0471@2|Bacteria,4NF52@976|Bacteroidetes,2FNWH@200643|Bacteroidia 976|Bacteroidetes P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - CitMHS,TrkA_C k59_450201_1 665950.HMPREF1025_02932 3.39e-71 228.0 COG2801@1|root,COG2801@2|Bacteria,1TSXX@1239|Firmicutes,24C90@186801|Clostridia 186801|Clostridia L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28,rve k59_222371_1 1211114.ALIP01000006_gene933 2.21e-23 101.0 COG0657@1|root,COG0657@2|Bacteria,1R79Q@1224|Proteobacteria,1S1MN@1236|Gammaproteobacteria,1X6G0@135614|Xanthomonadales 135614|Xanthomonadales I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 k59_614570_1 180332.JTGN01000003_gene1950 2.16e-33 130.0 COG1609@1|root,COG1609@2|Bacteria,1VE6I@1239|Firmicutes,25ENJ@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - - - - - - - - - - LacI,Peripla_BP_4 k59_1006427_1 105559.Nwat_0434 1.06e-84 273.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9 k59_254172_1 1123065.ATWL01000003_gene688 1.26e-88 266.0 COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria 201174|Actinobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_450211_1 243233.MCA0137 3.79e-98 292.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1XDWH@135618|Methylococcales 135618|Methylococcales E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_254174_1 387093.SUN_1906 3.38e-101 317.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2YMNT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_712005_1 368407.Memar_1426 1.1e-59 199.0 COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia 224756|Methanomicrobia P Citrate transporter - - - - - - - - - - - - CitMHS k59_712005_2 631362.Thi970DRAFT_04016 7.11e-22 92.4 COG0526@1|root,COG0526@2|Bacteria,1RJUZ@1224|Proteobacteria,1S6Y0@1236|Gammaproteobacteria,1WYNQ@135613|Chromatiales 135613|Chromatiales CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA k59_517830_1 2340.JV46_19830 4.08e-45 148.0 COG1366@1|root,COG1366@2|Bacteria,1N6U1@1224|Proteobacteria 1224|Proteobacteria T Belongs to the anti-sigma-factor antagonist family - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS,STAS_2 k59_517830_2 2340.JV46_19820 1.56e-29 116.0 COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,1RQIY@1236|Gammaproteobacteria,1JA7R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - GAF,GAF_2,HATPase_c_2,PAS,SpoIIE k59_806463_1 709032.Sulku_2091 1.45e-20 95.5 28HEC@1|root,2Z7QS@2|Bacteria,1QGH3@1224|Proteobacteria,42WU7@68525|delta/epsilon subdivisions,2YRR6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_222379_1 448385.sce7951 2.62e-13 68.2 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2WMPD@28221|Deltaproteobacteria,2YURE@29|Myxococcales 28221|Deltaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_222379_2 1304885.AUEY01000001_gene3234 1.65e-27 102.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2WPDP@28221|Deltaproteobacteria,2MJZV@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_285365_1 519989.ECTPHS_03854 2.34e-53 191.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_450218_1 1168034.FH5T_00770 2.56e-136 414.0 COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FM4Z@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 31 family - GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31,PA14 k59_1038473_1 1121405.dsmv_2113 1.18e-93 280.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,2MHSN@213118|Desulfobacterales 28221|Deltaproteobacteria S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_941281_1 1249627.D779_2709 4.45e-48 164.0 COG1449@1|root,COG1449@2|Bacteria,1Q9WP@1224|Proteobacteria,1S0Y4@1236|Gammaproteobacteria,1WX3Z@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_353557_1 298654.FraEuI1c_5776 1.07e-36 141.0 COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4ERR4@85013|Frankiales 201174|Actinobacteria L TIGRFAM ATP-dependent helicase HrpA hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_353557_2 1207076.ALAT01000146_gene473 1.83e-25 103.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria,1Z149@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Nucleoside triphosphate pyrophosphohydrolase mazG GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - iAF1260.b2781,iBWG_1329.BWG_2516,iE2348C_1286.E2348C_3048,iEC55989_1330.EC55989_3056,iECDH10B_1368.ECDH10B_2948,iECDH1ME8569_1439.ECDH1ME8569_2691,iECH74115_1262.ECH74115_4041,iECIAI1_1343.ECIAI1_2889,iECO103_1326.ECO103_3324,iECO111_1330.ECO111_3505,iECO26_1355.ECO26_3851,iECOK1_1307.ECOK1_3155,iECP_1309.ECP_2762,iECSE_1348.ECSE_3039,iECSP_1301.ECSP_3733,iECW_1372.ECW_m2990,iECs_1301.ECs3641,iEKO11_1354.EKO11_0987,iEcDH1_1363.EcDH1_0907,iEcE24377_1341.EcE24377A_3085,iEcHS_1320.EcHS_A2925,iEcolC_1368.EcolC_0931,iG2583_1286.G2583_3433,iJO1366.b2781,iJR904.b2781,iSBO_1134.SBO_2662,iSSON_1240.SSON_2938,iSbBS512_1146.SbBS512_E3092,iUMN146_1321.UM146_02665,iUMNK88_1353.UMNK88_3464,iUTI89_1310.UTI89_C3150,iWFL_1372.ECW_m2990,iY75_1357.Y75_RS14470,iZ_1308.Z4096 MazG k59_450219_1 1168034.FH5T_20560 3.61e-38 134.0 COG0846@1|root,COG0846@2|Bacteria,4NE9Q@976|Bacteroidetes,2FWW9@200643|Bacteroidia 976|Bacteroidetes K Sir2 family - - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_450219_2 1168034.FH5T_20565 2.63e-82 270.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_222387_1 1265505.ATUG01000001_gene4206 1.33e-72 229.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,42QRG@68525|delta/epsilon subdivisions,2WJ5Z@28221|Deltaproteobacteria,2MIYW@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_941284_1 504472.Slin_2663 1.3e-39 135.0 COG2963@1|root,COG2963@2|Bacteria,4NQ94@976|Bacteroidetes,47T18@768503|Cytophagia 976|Bacteroidetes L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_581802_1 1112217.PPL19_20451 6.37e-61 202.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J histidyl-tRNA synthetase hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His k59_581802_2 713586.KB900536_gene446 1.97e-08 54.3 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1WY25@135613|Chromatiales 135613|Chromatiales S protein conserved in bacteria - - - - - - - - - - - - TPR_21 k59_254179_1 572544.Ilyop_2843 3.08e-81 255.0 COG0471@1|root,COG0471@2|Bacteria 2|Bacteria P metal ion transport - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_254179_2 572544.Ilyop_2844 5.73e-96 284.0 COG0529@1|root,COG0529@2|Bacteria,37CSK@32066|Fusobacteria 32066|Fusobacteria F Adenylylsulphate kinase cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_254179_3 572544.Ilyop_2845 7.38e-217 611.0 COG1053@1|root,COG1053@2|Bacteria,37AQS@32066|Fusobacteria 32066|Fusobacteria C fumarate reductase succinate dehydrogenase flavoprotein domain protein - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_124015_1 161934.XP_010692517.1 9.03e-57 202.0 COG1132@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG0055@2759|Eukaryota,37SFN@33090|Viridiplantae,3GFGY@35493|Streptophyta 35493|Streptophyta Q ABC transporter B family member - - 3.6.3.44 ko:K05658 ko02010,ko04976,ko05206,ko05226,map02010,map04976,map05206,map05226 - - - ko00000,ko00001,ko01000,ko02000,ko04090,ko04147 3.A.1.201 - - ABC_membrane,ABC_tran k59_1006442_1 1168034.FH5T_09990 1.13e-141 409.0 COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes,2FNEC@200643|Bacteroidia 976|Bacteroidetes P Psort location CytoplasmicMembrane, score 10.00 amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_318471_2 1168034.FH5T_01385 5.43e-107 319.0 COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes,2FNEC@200643|Bacteroidia 976|Bacteroidetes P Psort location CytoplasmicMembrane, score 10.00 amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_222393_1 886379.AEWI01000050_gene3160 1.65e-91 283.0 COG1866@1|root,COG1866@2|Bacteria,4NEGI@976|Bacteroidetes,2FNYK@200643|Bacteroidia,3XJW9@558415|Marinilabiliaceae 976|Bacteroidetes C Phosphoenolpyruvate carboxykinase pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_517853_1 1168034.FH5T_06805 1.25e-112 342.0 COG0296@1|root,COG0296@2|Bacteria,4NECZ@976|Bacteroidetes,2FMTG@200643|Bacteroidia 976|Bacteroidetes G 1,4-alpha-glucan branching enzyme glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_680996_1 1223410.KN050846_gene2363 3.61e-92 297.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_941993_1 1207063.P24_07384 1.75e-37 145.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,2VEZT@28211|Alphaproteobacteria,2JR2N@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3 k59_807141_1 338963.Pcar_1046 9.72e-22 97.8 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,43RXD@69541|Desulfuromonadales 28221|Deltaproteobacteria M Penicillin-binding Protein dimerisation domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928 PBP_dimer,Transpeptidase k59_190788_1 1165841.SULAR_10179 1.7e-72 226.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2YMV8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10 ko:K00795 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364 R01658,R02003 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_842998_1 1121127.JAFA01000001_gene681 1.52e-131 408.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VN0R@28216|Betaproteobacteria,1K2NT@119060|Burkholderiaceae 28216|Betaproteobacteria C oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_386472_1 177437.HRM2_38320 1.86e-113 340.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,42P8V@68525|delta/epsilon subdivisions,2WKIF@28221|Deltaproteobacteria,2MJ7Z@213118|Desulfobacterales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.44 ko:K00666,ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_712706_1 1463845.JOIG01000006_gene1151 5.26e-39 146.0 COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria 201174|Actinobacteria P transporter sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_1039370_1 1168034.FH5T_06090 1.36e-85 261.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_1007100_1 519989.ECTPHS_01334 2.8e-44 158.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1WX4I@135613|Chromatiales 135613|Chromatiales D PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_648096_1 1121405.dsmv_1453 1.26e-38 130.0 2E6FN@1|root,3312Z@2|Bacteria,1N6QM@1224|Proteobacteria,42V22@68525|delta/epsilon subdivisions,2WRF9@28221|Deltaproteobacteria,2MM34@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_712709_1 1347369.CCAD010000054_gene166 1.41e-18 90.9 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,4HAG2@91061|Bacilli,1ZC16@1386|Bacillus 91061|Bacilli L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_386474_1 1105031.HMPREF1141_2336 1.66e-28 114.0 COG2826@1|root,COG2826@2|Bacteria,1TRSF@1239|Firmicutes,248IJ@186801|Clostridia 186801|Clostridia L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_38,rve k59_973936_2 247634.GPB2148_789 1.44e-62 201.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0501 Zn-dependent protease with chaperone function Z012_09445 - - - - - - - - - - - Peptidase_M48 k59_942012_1 1384056.N787_12830 1.21e-27 114.0 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1RKGT@1224|Proteobacteria,1S6ZQ@1236|Gammaproteobacteria,1X563@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the ompA family mopB - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 k59_223152_1 1168034.FH5T_05665 1.09e-11 63.9 COG2987@1|root,COG2987@2|Bacteria,4NF2P@976|Bacteroidetes,2FNQK@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_223152_2 1089553.Tph_c04760 4.66e-74 232.0 COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,42ER9@68295|Thermoanaerobacterales 186801|Clostridia E Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_57087_1 472759.Nhal_3504 1.49e-90 282.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales 135613|Chromatiales M PFAM Three-deoxy-D-manno-octulosonic-acid transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N,Kdo k59_223154_1 1121405.dsmv_3297 1.58e-24 93.2 COG1532@1|root,COG1532@2|Bacteria,1NHW7@1224|Proteobacteria,42X58@68525|delta/epsilon subdivisions,2WSZ3@28221|Deltaproteobacteria,2MNT6@213118|Desulfobacterales 28221|Deltaproteobacteria S Predicted RNA-binding protein - - - - - - - - - - - - RNA_bind_2 k59_92082_1 1123053.AUDG01000070_gene1423 1.35e-51 169.0 COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,1RPTX@1236|Gammaproteobacteria,1WVW9@135613|Chromatiales 135613|Chromatiales S protein conserved in bacteria - - - - - - - - - - - - AAA_29,SbcCD_C k59_92082_2 243265.plu0107 6.87e-31 117.0 2BW5S@1|root,2Z8JM@2|Bacteria,1R3MV@1224|Proteobacteria,1S1QY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4194) - - - - - - - - - - - - DUF4194 k59_843021_1 933262.AXAM01000029_gene2745 6.49e-82 252.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,2MHVT@213118|Desulfobacterales 28221|Deltaproteobacteria C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_57092_1 1129794.C427_2477 1.42e-63 207.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,1SZQR@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_417804_1 1168034.FH5T_13605 3.21e-118 360.0 COG1048@1|root,COG1048@2|Bacteria,4NDZT@976|Bacteroidetes,2FMDQ@200643|Bacteroidia 976|Bacteroidetes C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_417804_2 1122180.Lokhon_00251 1.31e-22 95.1 COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,2P851@245186|Loktanella 28211|Alphaproteobacteria C Isocitrate/isopropylmalate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_648117_1 1121405.dsmv_3010 1.16e-67 217.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N28@68525|delta/epsilon subdivisions,2WJVR@28221|Deltaproteobacteria,2MIFN@213118|Desulfobacterales 28221|Deltaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily hemU - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_777972_2 1026882.MAMP_00795 1.05e-06 48.1 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,460WP@72273|Thiotrichales 72273|Thiotrichales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_648123_1 292415.Tbd_0044 8.83e-45 160.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,1KS4R@119069|Hydrogenophilales 119069|Hydrogenophilales C 4Fe-4S dicluster domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7 k59_92091_1 484018.BACPLE_00582 1.53e-89 275.0 COG0151@1|root,COG0151@2|Bacteria,4NEUN@976|Bacteroidetes,2FN59@200643|Bacteroidia,4AM0C@815|Bacteroidaceae 976|Bacteroidetes F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_843031_1 643473.KB235930_gene3503 1.11e-74 236.0 COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,1HMN9@1161|Nostocales 1117|Cyanobacteria GM ABC-type polysaccharide polyol phosphate transport system ATPase component - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_582711_2 1120953.AUBH01000006_gene2608 9.1e-29 115.0 COG5309@1|root,COG5309@2|Bacteria,1Q5JR@1224|Proteobacteria,1SJJ9@1236|Gammaproteobacteria 2|Bacteria G Glycosyl hydrolases family 17 - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_17 k59_712738_1 1121428.DESHY_110324___1 1.87e-25 107.0 COG0457@1|root,COG0463@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,1TSF5@1239|Firmicutes,25B5G@186801|Clostridia,2619D@186807|Peptococcaceae 186801|Clostridia M glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,TPR_16,TPR_2,TPR_8 k59_777982_1 314724.BT0431 8.29e-21 90.5 COG1192@1|root,COG1192@2|Bacteria,2J5VP@203691|Spirochaetes 203691|Spirochaetes D CobQ CobB MinD ParA nucleotide binding domain soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_550128_1 537013.CLOSTMETH_01915 7.68e-43 159.0 COG1196@1|root,COG3250@1|root,COG1196@2|Bacteria,COG3250@2|Bacteria,1V1D9@1239|Firmicutes,24H7I@186801|Clostridia 2|Bacteria G Psort location sca1 - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF4988,F5_F8_type_C,FIVAR,Glyco_hydro_106,Glyco_hydro_2_N,RicinB_lectin_2 k59_57120_1 1177179.A11A3_17191 4.32e-75 233.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,1XPHQ@135619|Oceanospirillales 135619|Oceanospirillales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_807192_1 1187848.AJYQ01000008_gene535 2.72e-35 134.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1XV2J@135623|Vibrionales 135623|Vibrionales E COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_386525_1 933262.AXAM01000016_gene153 5.19e-77 240.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2WM37@28221|Deltaproteobacteria,2MI98@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_777987_1 98439.AJLL01000089_gene3780 3.82e-31 126.0 COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria 1117|Cyanobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_354190_1 754476.Q7A_2839 3.21e-104 317.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales 72273|Thiotrichales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_973972_1 1085623.GNIT_1040 1.44e-34 126.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria,4656V@72275|Alteromonadaceae 1236|Gammaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_286375_1 1121396.KB893100_gene4325 5.62e-54 184.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,42T05@68525|delta/epsilon subdivisions,2WPA4@28221|Deltaproteobacteria,2MNJS@213118|Desulfobacterales 28221|Deltaproteobacteria S ABC1 family - - - - - - - - - - - - ABC1,APH k59_319153_1 1049564.TevJSym_ad00290 5.93e-31 122.0 COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2309) - - - ko:K09822 - - - - ko00000 - - - DUF2309 k59_319153_2 472759.Nhal_2897 1.65e-25 105.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales 135613|Chromatiales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_743993_1 596151.DesfrDRAFT_3661 5.28e-20 91.7 COG2204@1|root,COG2204@2|Bacteria,1MWW5@1224|Proteobacteria,42PBX@68525|delta/epsilon subdivisions,2WJY3@28221|Deltaproteobacteria,2M7YD@213115|Desulfovibrionales 28221|Deltaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - ko:K03974 - - - - ko00000,ko03000 - - - HTH_8,Sigma54_activat k59_386540_2 751944.HALDL1_02985 2.16e-50 170.0 COG0714@1|root,arCOG00435@2157|Archaea,2XTD9@28890|Euryarchaeota,23S4I@183963|Halobacteria 183963|Halobacteria S COG0714 MoxR-like ATPases moxR3 - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_451223_2 525257.HMPREF0204_11338 2.1e-16 79.3 COG0270@1|root,COG0270@2|Bacteria,4P3NG@976|Bacteroidetes,1I91K@117743|Flavobacteriia 976|Bacteroidetes L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_914262_1 1188256.BASI01000005_gene2101 1.66e-54 186.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,3FCRD@34008|Rhodovulum 28211|Alphaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain gor GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_881130_1 97096.XP_007790272.1 4.94e-56 194.0 COG0056@1|root,KOG1353@2759|Eukaryota,38ERH@33154|Opisthokonta,3NUHW@4751|Fungi,3QKF2@4890|Ascomycota,21306@147550|Sordariomycetes 4751|Fungi C Produces ATP from ADP in the presence of a proton gradient across the membrane ATP1 GO:0000166,GO:0000275,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0005754,GO:0005759,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006839,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009295,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016310,GO:0016469,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0030554,GO:0031090,GO:0031224,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042645,GO:0042776,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045259,GO:0045261,GO:0045267,GO:0046034,GO:0046390,GO:0046483,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0055086,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902600,GO:1990542 - ko:K02132 ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016 M00158 - - ko00000,ko00001,ko00002 3.A.2.1 - iMM904.YBL099W,iND750.YBL099W ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_324900_1 631362.Thi970DRAFT_04432 1.15e-110 331.0 COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales 135613|Chromatiales P Sodium/hydrogen exchanger family - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_653463_2 1123326.JFBL01000020_gene2656 1.67e-74 227.0 COG1247@1|root,COG1247@2|Bacteria,1R9WS@1224|Proteobacteria,42RZM@68525|delta/epsilon subdivisions,2YP9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_914292_1 1510531.JQJJ01000008_gene3788 4.52e-48 158.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,2U997@28211|Alphaproteobacteria,3JV5Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Belongs to the UPF0178 family MA20_27470 - - ko:K09768 - - - - ko00000 - - - DUF188 k59_813444_1 641149.HMPREF9016_01290 5.33e-10 56.2 2CHW3@1|root,32S6N@2|Bacteria,1N0I3@1224|Proteobacteria,2VW65@28216|Betaproteobacteria,2KRZK@206351|Neisseriales 206351|Neisseriales S Pathogenicity locus - - - - - - - - - - - - Cdd1 k59_813444_2 314292.VAS14_06043 4.93e-20 89.4 COG3637@1|root,COG3637@2|Bacteria,1NYQT@1224|Proteobacteria,1SQP5@1236|Gammaproteobacteria,1XYDQ@135623|Vibrionales 135623|Vibrionales M OmpA-like transmembrane domain - - - - - - - - - - - - OMP_b-brl k59_1012625_1 1268237.G114_13823 3.4e-52 173.0 COG1718@1|root,COG1718@2|Bacteria,1QV96@1224|Proteobacteria,1T2AM@1236|Gammaproteobacteria,1Y48X@135624|Aeromonadales 135624|Aeromonadales H Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position kdkA - 2.7.1.166 ko:K11211 ko00540,map00540 - R09767 RC00002,RC00078 ko00000,ko00001,ko01000 - - - Kdo k59_1012625_2 1216976.AX27061_5861 7.99e-10 59.3 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,3T1R5@506|Alcaligenaceae 28216|Betaproteobacteria M Acyltransferase htrB1 - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_260803_2 258052.JNYV01000002_gene1502 2.07e-12 68.6 COG0300@1|root,COG0300@2|Bacteria,2I2R6@201174|Actinobacteria 201174|Actinobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_324915_1 1249480.B649_01340 2.62e-104 326.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2YMNT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_292086_1 1415779.JOMH01000001_gene2359 2.23e-109 323.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1X3Z0@135614|Xanthomonadales 135614|Xanthomonadales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_979880_1 1511.CLOST_1952 9.31e-117 348.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,25S1D@186804|Peptostreptococcaceae 186801|Clostridia F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_26922_1 391625.PPSIR1_16165 4.31e-99 315.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,42PUY@68525|delta/epsilon subdivisions,2WM1C@28221|Deltaproteobacteria,2YXTJ@29|Myxococcales 28221|Deltaproteobacteria HJ RimK-like ATP-grasp domain - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Mur_ligase_C,Mur_ligase_M,RimK k59_718606_1 1219045.BV98_002185 7.84e-07 57.0 COG0845@1|root,COG0845@2|Bacteria,1P540@1224|Proteobacteria,2U20J@28211|Alphaproteobacteria,2K2CE@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_324920_2 555779.Dthio_PD0397 4.71e-29 113.0 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria 1224|Proteobacteria L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_653510_1 177437.HRM2_40260 7.16e-78 246.0 COG0663@1|root,COG0663@2|Bacteria,1N42I@1224|Proteobacteria,42NWC@68525|delta/epsilon subdivisions,2WIYQ@28221|Deltaproteobacteria,2MIDD@213118|Desulfobacterales 28221|Deltaproteobacteria S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - - - - - - - - - - Hexapep k59_97445_1 563040.Saut_0647 3.9e-92 283.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2YMVE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G phosphomannomutase glmM_1 - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_130486_1 665950.HMPREF1025_01359 1.3e-22 102.0 COG5362@1|root,COG5362@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_423484_1 1123518.ARWI01000001_gene400 9.47e-53 186.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_62876_1 1283284.AZUK01000001_gene2002 1.03e-62 215.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1Y3WP@135624|Aeromonadales 135624|Aeromonadales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_423486_1 1144310.PMI07_003967 1.58e-11 62.4 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2TSQ0@28211|Alphaproteobacteria,4B8XX@82115|Rhizobiaceae 28211|Alphaproteobacteria G Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_423486_2 1122185.N792_00750 1.87e-18 85.1 COG0463@1|root,COG0463@2|Bacteria,1QX0V@1224|Proteobacteria,1T32V@1236|Gammaproteobacteria,1X4VQ@135614|Xanthomonadales 135614|Xanthomonadales M glycosyl transferase family 2 - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 k59_718620_1 1168034.FH5T_13320 7e-72 235.0 COG1482@1|root,COG1482@2|Bacteria,4NF9A@976|Bacteroidetes,2FNY1@200643|Bacteroidia 976|Bacteroidetes G mannose-6-phosphate isomerase, class I - - - - - - - - - - - - ROK k59_130490_1 1249480.B649_09215 1.24e-33 122.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2YNZB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_130490_2 929558.SMGD1_1367 1.46e-82 249.0 COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,42QX6@68525|delta/epsilon subdivisions 1224|Proteobacteria S Las17-binding protein actin regulator CT2216 - - - - - - - - - - - Ysc84 k59_749604_1 572544.Ilyop_1534 9.43e-30 113.0 COG0583@1|root,COG0583@2|Bacteria,37B00@32066|Fusobacteria 32066|Fusobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_947848_1 1168034.FH5T_14470 1.12e-93 287.0 COG1030@1|root,COG1030@2|Bacteria,4NGGV@976|Bacteroidetes,2FP4N@200643|Bacteroidia 976|Bacteroidetes O serine protease - - - ko:K07403 - - - - ko00000 - - - NfeD,Peptidase_S49,SDH_sah k59_488317_1 765914.ThisiDRAFT_1225 1.37e-32 122.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1WWPU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_488317_2 1049564.TevJSym_ab02100 4.89e-296 815.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1J4CY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_488317_3 1134474.O59_001302 1.18e-38 152.0 COG2206@1|root,COG2206@2|Bacteria,1MWDU@1224|Proteobacteria,1S7D9@1236|Gammaproteobacteria,1FHBD@10|Cellvibrio 1236|Gammaproteobacteria T HD domain - - - - - - - - - - - - HD,HD_5 k59_488317_4 42099.EPrPV00000018353 2.39e-17 84.0 COG1498@1|root,KOG2572@2759|Eukaryota,1MAVN@121069|Pythiales 121069|Pythiales AJ Nucleolar protein NOP5. Source PGD - - - - - - - - - - - - NOP5NT,Nop k59_488317_5 1366050.N234_21725 9.53e-14 67.8 COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,2VWG2@28216|Betaproteobacteria,1K8MX@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM Excinuclease ABC, C subunit domain protein - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_488317_6 1123507.ATVQ01000001_gene1965 5.65e-27 99.8 COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,1WA1P@1268|Micrococcaceae 201174|Actinobacteria K 'Cold-shock' DNA-binding domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_488317_7 1040989.AWZU01000005_gene357 3.79e-40 137.0 COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,2UGVG@28211|Alphaproteobacteria,3K235@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Hsp20/alpha crystallin family - - - - - - - - - - - - HSP20 k59_488317_10 314230.DSM3645_06881 0.0 1241.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2IX63@203682|Planctomycetes 203682|Planctomycetes G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_488317_11 357804.Ping_2025 8.22e-112 339.0 COG0745@1|root,COG2200@1|root,COG0745@2|Bacteria,COG2200@2|Bacteria,1NWAF@1224|Proteobacteria,1T243@1236|Gammaproteobacteria 1236|Gammaproteobacteria T response regulator - - 3.1.4.52 ko:K13246 ko05111,map05111 - R08991 RC00296 ko00000,ko00001,ko01000 - - - EAL,Response_reg k59_488317_12 1415778.JQMM01000001_gene2129 2.93e-97 336.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,1J53Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_488317_13 243233.MCA2737 1.17e-27 106.0 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_488317_14 639283.Snov_1066 1.76e-48 163.0 COG1376@1|root,COG1376@2|Bacteria,1MUAB@1224|Proteobacteria,2TTXM@28211|Alphaproteobacteria,3EZXJ@335928|Xanthobacteraceae 28211|Alphaproteobacteria S L,D-transpeptidase catalytic domain MA20_01915 - - - - - - - - - - - YkuD k59_488317_16 439235.Dalk_0184 1.58e-29 117.0 COG3064@1|root,COG3064@2|Bacteria,1MZUF@1224|Proteobacteria,42U5X@68525|delta/epsilon subdivisions,2WPJ1@28221|Deltaproteobacteria,2MK9T@213118|Desulfobacterales 28221|Deltaproteobacteria M SprA-related family - - - - - - - - - - - - SprA-related k59_488317_17 349521.HCH_06431 0.0 1551.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1XIVW@135619|Oceanospirillales 135619|Oceanospirillales EQ N-methylhydantoinase A acetone carboxylase, beta subunit hyuA - 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_488317_18 207954.MED92_15053 4.62e-210 586.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XMZH@135619|Oceanospirillales 135619|Oceanospirillales P Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_488317_19 1208321.D104_07870 2.76e-76 233.0 COG4665@1|root,COG4665@2|Bacteria,1REH8@1224|Proteobacteria,1S44W@1236|Gammaproteobacteria,1XK8V@135619|Oceanospirillales 135619|Oceanospirillales Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_488317_20 207954.MED92_15043 2.59e-238 663.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XHXR@135619|Oceanospirillales 135619|Oceanospirillales Q TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_488317_23 1248232.BANQ01000059_gene2084 1.54e-224 630.0 COG0688@1|root,COG0688@2|Bacteria,1NEF8@1224|Proteobacteria,1S006@1236|Gammaproteobacteria,1XWSQ@135623|Vibrionales 135623|Vibrionales I Phophatidylserine decarboxylase - - - - - - - - - - - - PSDC,PS_Dcarbxylase k59_488317_24 1121456.ATVA01000015_gene2426 0.000316 48.1 2E83A@1|root,332H7@2|Bacteria,1NK62@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - VPEP k59_292110_1 1168034.FH5T_10610 5.4e-177 498.0 COG1087@1|root,COG1087@2|Bacteria,4NEM9@976|Bacteroidetes,2FMV2@200643|Bacteroidia 976|Bacteroidetes M UDP-glucose 4-epimerase galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_749606_1 1479238.JQMZ01000001_gene1360 1.82e-41 149.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,43WFZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_260843_1 439235.Dalk_4962 4.85e-115 342.0 COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42N63@68525|delta/epsilon subdivisions,2WJPA@28221|Deltaproteobacteria,2MHPB@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM nickel-dependent hydrogenase large subunit - - 1.8.98.5 ko:K14126 ko00680,map00680 - R00019,R11943 RC00011 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_26942_1 395493.BegalDRAFT_2029 1.74e-33 127.0 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,1RQGC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S auxin efflux carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_718648_1 767817.Desgi_0556 8.96e-40 142.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia,260BK@186807|Peptococcaceae 186801|Clostridia S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_130520_1 2340.JV46_16770 2.45e-62 198.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1J5E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoB GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_26955_1 1121127.JAFA01000006_gene5692 3.61e-25 111.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - - k59_947869_1 1249627.D779_3217 1.76e-82 256.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1WWET@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class I and II - - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_130525_2 617140.AJZE01000090_gene4180 5.45e-29 115.0 COG2213@1|root,COG4668@1|root,COG2213@2|Bacteria,COG4668@2|Bacteria,1MUPU@1224|Proteobacteria,1RNAG@1236|Gammaproteobacteria,1XSK5@135623|Vibrionales 135623|Vibrionales G PTS system mannitol-specific transporter subunit IICBA mtlA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015166,GO:0015318,GO:0015575,GO:0015791,GO:0015797,GO:0015850,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:1901618 2.7.1.197 ko:K02798,ko:K02799,ko:K02800 ko00051,ko02060,map00051,map02060 M00274 R02704 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB k59_292144_1 1384056.N787_04290 2.46e-91 288.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1X42Y@135614|Xanthomonadales 135614|Xanthomonadales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HHH_5,Helicase_C,RecG_wedge k59_783896_1 1322246.BN4_12750 5.32e-65 220.0 COG1042@1|root,COG1042@2|Bacteria,1NU6B@1224|Proteobacteria,42NAU@68525|delta/epsilon subdivisions,2WJHX@28221|Deltaproteobacteria,2M8HI@213115|Desulfovibrionales 28221|Deltaproteobacteria C ATP-grasp domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_914343_1 29730.Gorai.001G168000.1 4.08e-25 98.6 COG0839@1|root,2S14H@2759|Eukaryota,389Z6@33090|Viridiplantae,3GX82@35493|Streptophyta 35493|Streptophyta C Belongs to the complex I subunit 6 family NAD6 - 1.6.5.3 ko:K03884 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - Oxidored_q3 k59_947880_1 504487.JCM19302_3886 1.17e-82 272.0 COG0060@1|root,COG0060@2|Bacteria,4NEYT@976|Bacteroidetes,1HX3Y@117743|Flavobacteriia 976|Bacteroidetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_292151_1 754477.Q7C_1957 5.5e-36 134.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1S2IK@1236|Gammaproteobacteria,463P1@72273|Thiotrichales 72273|Thiotrichales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_849928_1 387093.SUN_1510 5.03e-72 234.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MA6@68525|delta/epsilon subdivisions,2YMMG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V COG0841 Cation multidrug efflux pump - - - - - - - - - - - - ACR_tran k59_814909_1 1408473.JHXO01000003_gene2561 8.03e-54 179.0 COG1814@1|root,COG1814@2|Bacteria,4NIYX@976|Bacteroidetes,2FMRI@200643|Bacteroidia 976|Bacteroidetes S VIT family - - - - - - - - - - - - Rubrerythrin,VIT1 k59_490157_1 583355.Caka_3035 1.16e-65 215.0 COG0165@1|root,COG0165@2|Bacteria,46SCX@74201|Verrucomicrobia,3KA2P@414999|Opitutae 414999|Opitutae E Argininosuccinate lyase C-terminal argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_814913_2 498211.CJA_3047 5.99e-17 79.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria 1224|Proteobacteria U Rhs Element Vgr Protein - - - - - - - - - - - - - k59_814915_1 1521187.JPIM01000229_gene2475 6.96e-11 68.6 COG5421@1|root,COG5421@2|Bacteria,2G7SD@200795|Chloroflexi,376XS@32061|Chloroflexia 32061|Chloroflexia L COGs COG5421 Transposase - - - - - - - - - - - - - k59_293583_1 1168034.FH5T_06500 2.09e-110 326.0 COG2876@1|root,COG2876@2|Bacteria,4NDU4@976|Bacteroidetes,2FPF1@200643|Bacteroidia 976|Bacteroidetes E 3-deoxy-7-phosphoheptulonate synthase pheB - 5.4.99.5 ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,DAHP_synth_1 k59_490171_1 1121405.dsmv_1928 1.48e-151 440.0 COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MHVG@213118|Desulfobacterales 28221|Deltaproteobacteria C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - iAF987.Gmet_2834 Prismane k59_490172_1 572544.Ilyop_1474 1.25e-62 212.0 COG0553@1|root,COG0553@2|Bacteria,3788I@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Helicase_C,SNF2_N k59_490172_2 572544.Ilyop_1473 1.11e-186 539.0 28IHG@1|root,2Z8IP@2|Bacteria,3797X@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_751485_1 1517681.HW45_21795 2.1e-71 215.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1XXC2@135623|Vibrionales 135623|Vibrionales C Belongs to the glutaredoxin family. Monothiol subfamily grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_293600_1 913325.N799_01200 9.68e-72 233.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X4H3@135614|Xanthomonadales 135614|Xanthomonadales M Small-conductance mechanosensitive channel mscK - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - DUF3772,MS_channel k59_293602_1 658655.HMPREF0988_02765 1.09e-65 217.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,27IFR@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_462845_3 1537917.JU82_08600 3.69e-17 80.5 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,42P0P@68525|delta/epsilon subdivisions,2YN3S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Na H antiporter nhaC - - - - - - - - - - - Na_H_antiporter k59_135843_1 1415780.JPOG01000001_gene2196 2.98e-19 85.5 COG3714@1|root,COG3714@2|Bacteria,1QE44@1224|Proteobacteria,1TAFY@1236|Gammaproteobacteria,1X8EB@135614|Xanthomonadales 135614|Xanthomonadales S YhhN family - - - - - - - - - - - - YhhN k59_135843_2 591159.ACEZ01000197_gene2841 6.25e-29 118.0 COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria 201174|Actinobacteria C malic enzyme - - 1.1.1.38,4.1.1.101 ko:K00027,ko:K22212 ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020 - R00214,R11074 RC00105,RC00282 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_985101_1 694440.JOMF01000008_gene961 6.14e-45 155.0 COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia 224756|Methanomicrobia H PFAM UBA THIF-type NAD FAD binding protein - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - iAF692.Mbar_A1238 ThiF k59_592540_1 187272.Mlg_0172 1.87e-120 367.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_298453_1 1121937.AUHJ01000007_gene1873 1.97e-40 136.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,466TX@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the glutaredoxin family. Monothiol subfamily grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin,Rhodanese k59_298453_3 247633.GP2143_00577 9.78e-15 73.2 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1J4KG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the NadC ModD family nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0109 QRPTase_C,QRPTase_N k59_723640_2 768671.ThimaDRAFT_0532 1.5e-21 86.7 2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,1SGKD@1236|Gammaproteobacteria,1WYKI@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 k59_789047_1 1265505.ATUG01000003_gene670 8.03e-08 53.5 COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,42RIS@68525|delta/epsilon subdivisions,2WMWC@28221|Deltaproteobacteria,2MJR1@213118|Desulfobacterales 28221|Deltaproteobacteria S Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_789047_2 879212.DespoDRAFT_01948 2.8e-90 268.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WNNG@28221|Deltaproteobacteria,2MNHD@213118|Desulfobacterales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_69876_1 580332.Slit_0824 1.11e-54 181.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VNWB@28216|Betaproteobacteria 28216|Betaproteobacteria E PFAM aminotransferase class V - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_36881_1 243233.MCA1000 1.89e-42 149.0 2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,1S7TX@1236|Gammaproteobacteria,1XFDM@135618|Methylococcales 135618|Methylococcales S Ceramidase - - - - - - - - - - - - Ceramidase k59_625695_1 1105367.CG50_07965 3.47e-80 247.0 COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,2TUE7@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_886624_1 929558.SMGD1_1236 1.35e-94 284.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,43B0D@68525|delta/epsilon subdivisions,2YT4V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RluA family - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_396962_2 1245471.PCA10_17350 3.9e-62 201.0 COG0604@1|root,COG0604@2|Bacteria,1MXCV@1224|Proteobacteria,1S13Q@1236|Gammaproteobacteria,1YCZ2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_985126_1 1408473.JHXO01000006_gene1174 8.92e-56 194.0 COG1629@1|root,COG4771@2|Bacteria,4NEHN@976|Bacteroidetes,2FNEZ@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_985126_2 1168034.FH5T_03195 1.02e-58 193.0 COG0251@1|root,COG0251@2|Bacteria,4NEVA@976|Bacteroidetes,2FN38@200643|Bacteroidia 976|Bacteroidetes J endoribonuclease L-PSP - - - - - - - - - - - - - k59_69894_1 439375.Oant_3019 1.09e-18 83.2 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2TT0H@28211|Alphaproteobacteria,1J2H7@118882|Brucellaceae 28211|Alphaproteobacteria F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_69894_2 1101189.AQUO01000001_gene2350 3.6e-15 73.2 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,2PU7Y@265|Paracoccus 28211|Alphaproteobacteria G Ribulose-phosphate 3 epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_495218_1 1255043.TVNIR_2584 4.92e-121 350.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1WW17@135613|Chromatiales 135613|Chromatiales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_495218_2 317025.Tcr_0284 2.11e-05 44.7 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,460I0@72273|Thiotrichales 72273|Thiotrichales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_265716_2 395964.KE386496_gene2582 8.2e-49 164.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,3N9QI@45404|Beijerinckiaceae 28211|Alphaproteobacteria Q ATPases associated with a variety of cellular activities yrbF - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_528069_1 626887.J057_14425 2.16e-16 78.6 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,465IC@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG4972 Tfp pilus assembly protein, ATPase PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_528069_2 713586.KB900536_gene1830 6.24e-44 160.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_625700_1 1537917.JU82_02565 5.25e-190 547.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2YMIP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_462859_1 572544.Ilyop_1435 8.87e-11 58.9 COG0102@1|root,COG0102@2|Bacteria,379Z6@32066|Fusobacteria 32066|Fusobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_462859_3 572544.Ilyop_1436 4.36e-78 241.0 2C4JC@1|root,2Z81M@2|Bacteria,379SV@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_462859_5 471855.Shel_05390 4.56e-69 233.0 COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4CUG1@84998|Coriobacteriia 201174|Actinobacteria H tRNA nucleotidyltransferase poly(A) polymerase - - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - PolyA_pol k59_234064_1 439235.Dalk_3415 1.63e-76 255.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MMWB@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_429534_2 1121935.AQXX01000120_gene4886 1.18e-68 215.0 2EP04@1|root,33GKY@2|Bacteria,1NKWH@1224|Proteobacteria,1SU2W@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_298888_1 384765.SIAM614_02581 1.06e-93 291.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_495539_2 1123034.JMKP01000001_gene2011 6.52e-12 68.9 290D9@1|root,2ZN2P@2|Bacteria,1PA9E@1224|Proteobacteria,1SWC9@1236|Gammaproteobacteria,3NSG9@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_985580_1 563040.Saut_1135 2.68e-24 100.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,42NEN@68525|delta/epsilon subdivisions,2YN4D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_593029_1 439235.Dalk_2466 9.97e-102 308.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,42NKV@68525|delta/epsilon subdivisions,2WKPA@28221|Deltaproteobacteria,2MIDW@213118|Desulfobacterales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_593029_2 1150626.PHAMO_270085 1.13e-33 123.0 COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria,2JRKC@204441|Rhodospirillales 204441|Rhodospirillales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_364796_1 479434.Sthe_3153 2.31e-47 164.0 COG1108@1|root,COG1108@2|Bacteria,2G7XS@200795|Chloroflexi 200795|Chloroflexi P PFAM ABC-3 protein - - - ko:K11709 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ABC-3 k59_169240_1 1168034.FH5T_05425 4.94e-52 164.0 COG0234@1|root,COG0234@2|Bacteria,4NS7D@976|Bacteroidetes,2FT5R@200643|Bacteroidia 976|Bacteroidetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_169240_2 1168034.FH5T_05420 3.33e-221 621.0 COG0459@1|root,COG0459@2|Bacteria,4NDZM@976|Bacteroidetes,2FMH4@200643|Bacteroidia 976|Bacteroidetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_266143_2 177437.HRM2_44670 1.36e-147 421.0 COG3267@1|root,COG3267@2|Bacteria,1Q4DA@1224|Proteobacteria,42YYB@68525|delta/epsilon subdivisions,2WU9J@28221|Deltaproteobacteria 28221|Deltaproteobacteria U AAA domain - - - - - - - - - - - - AAA_22 k59_266143_3 177437.HRM2_44660 1.77e-96 296.0 COG2801@1|root,COG2801@2|Bacteria,1MUSB@1224|Proteobacteria,43AFH@68525|delta/epsilon subdivisions,2X5V7@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_364802_1 293826.Amet_1450 1.57e-80 251.0 COG1741@1|root,COG1741@2|Bacteria,1TQDV@1239|Firmicutes,2497R@186801|Clostridia,36G31@31979|Clostridiaceae 186801|Clostridia S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_495551_1 395494.Galf_0768 4.61e-70 217.0 COG2010@1|root,COG2010@2|Bacteria,1RG22@1224|Proteobacteria,2W8VP@28216|Betaproteobacteria,44WMU@713636|Nitrosomonadales 1224|Proteobacteria C PFAM cytochrome c class I - - - ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 - - Cytochrom_C k59_495551_2 243233.MCA2400 1.61e-19 87.4 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1XE9J@135618|Methylococcales 135618|Methylococcales P Cytochrome C and Quinol oxidase polypeptide I - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_789527_1 1168034.FH5T_08045 2.29e-124 364.0 COG3659@1|root,COG3659@2|Bacteria 2|Bacteria M wide pore channel activity - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB,SLH k59_691574_1 1168034.FH5T_04900 8.2e-66 213.0 COG0726@1|root,COG0726@2|Bacteria,4NF79@976|Bacteroidetes,2FR2H@200643|Bacteroidia 976|Bacteroidetes G polysaccharide deacetylase - - - - - - - - - - - - - k59_691574_2 1168034.FH5T_04905 2.14e-32 121.0 COG5653@1|root,COG5653@2|Bacteria,4NQN5@976|Bacteroidetes,2FT4P@200643|Bacteroidia 976|Bacteroidetes M Protein involved in cellulose biosynthesis - - - - - - - - - - - - Acetyltransf_6 k59_1018505_1 349106.PsycPRwf_1051 1.11e-25 113.0 COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,3NQKB@468|Moraxellaceae 1236|Gammaproteobacteria Q von willebrand factor, type A - - - - - - - - - - - - Big_3_2,Big_3_3,VCBS k59_920848_1 380358.XALC_0113 2.77e-42 156.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1X3W3@135614|Xanthomonadales 135614|Xanthomonadales L Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_789531_1 749222.Nitsa_1258 3.6e-43 156.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YNAB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DEAD DEAH box helicase deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C k59_70421_1 382464.ABSI01000011_gene2511 7.92e-19 91.3 COG2211@1|root,COG2211@2|Bacteria,46UFW@74201|Verrucomicrobia 74201|Verrucomicrobia G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_463409_1 64471.sync_2670 3.31e-41 138.0 COG1359@1|root,COG1359@2|Bacteria,1GPHI@1117|Cyanobacteria,1H397@1129|Synechococcus 1117|Cyanobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_463409_2 316057.RPD_1049 1.59e-06 49.3 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TUHD@28211|Alphaproteobacteria 28211|Alphaproteobacteria C alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_234085_1 4081.Solyc01g007640.2.1 3.4e-249 746.0 2CMQD@1|root,2QRDV@2759|Eukaryota,37QIN@33090|Viridiplantae,3GEA1@35493|Streptophyta,44PKI@71274|asterids 35493|Streptophyta C Plant protein of unknown function (DUF825) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009509,GO:0009532,GO:0009536,GO:0009570,GO:0009575,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 - - - - - - - - - - AAA,DUF825 k59_887098_1 469616.FMAG_00789 5.29e-74 235.0 COG4591@1|root,COG4591@2|Bacteria,378S1@32066|Fusobacteria 32066|Fusobacteria M Psort location CytoplasmicMembrane, score 10.00 - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_887098_2 572544.Ilyop_0509 1.98e-09 57.0 COG1136@1|root,COG1136@2|Bacteria,379JG@32066|Fusobacteria 32066|Fusobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_463410_1 105559.Nwat_0843 1.04e-116 347.0 COG5361@1|root,COG5361@2|Bacteria,1NBVB@1224|Proteobacteria,1SES6@1236|Gammaproteobacteria,1X1NF@135613|Chromatiales 135613|Chromatiales S Neurotransmitter-gated ion-channel ligand binding domain - - - - - - - - - - - - Neur_chan_LBD k59_691586_1 1123037.AUDE01000020_gene3566 5.35e-21 94.4 COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,1HZ28@117743|Flavobacteriia 976|Bacteroidetes L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_756427_1 1122603.ATVI01000009_gene2498 1.21e-37 152.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1X37S@135614|Xanthomonadales 135614|Xanthomonadales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_593057_1 207559.Dde_1931 4.17e-119 348.0 2CDJ3@1|root,2Z7R6@2|Bacteria,1PZM0@1224|Proteobacteria,42P6U@68525|delta/epsilon subdivisions,2WMMY@28221|Deltaproteobacteria,2MCXK@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_822488_3 1249627.D779_2444 8.92e-97 295.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1WWRW@135613|Chromatiales 135613|Chromatiales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_1018525_1 1249480.B649_07895 1.79e-59 201.0 COG1538@1|root,COG1538@2|Bacteria,1QNYC@1224|Proteobacteria,42TDW@68525|delta/epsilon subdivisions,2YPR5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_298925_2 1565314.OA34_06755 2.14e-19 86.7 COG1433@1|root,COG1433@2|Bacteria,1PBVD@1224|Proteobacteria,42VRB@68525|delta/epsilon subdivisions,2YQI4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_298925_3 765913.ThidrDRAFT_2889 5.27e-10 57.4 2B5BG@1|root,31Y5N@2|Bacteria,1RJ1N@1224|Proteobacteria,1S56J@1236|Gammaproteobacteria,1WYC6@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_659405_1 375286.mma_1634 1.46e-86 266.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,4726F@75682|Oxalobacteraceae 28216|Betaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_561321_1 325777.GW15_0216835 2.63e-54 183.0 COG0697@1|root,COG0697@2|Bacteria,1MXPW@1224|Proteobacteria,1SB7X@1236|Gammaproteobacteria,1X5BG@135614|Xanthomonadales 135614|Xanthomonadales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1018528_1 1408473.JHXO01000010_gene3512 7.23e-83 252.0 COG1187@1|root,COG1187@2|Bacteria,4NEE1@976|Bacteroidetes,2FP7M@200643|Bacteroidia 976|Bacteroidetes J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_136429_1 572544.Ilyop_0381 1.49e-49 173.0 COG1538@1|root,COG1538@2|Bacteria,37A6H@32066|Fusobacteria 32066|Fusobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_528676_1 472759.Nhal_0272 3.49e-63 213.0 COG0845@1|root,COG0845@2|Bacteria,1NKWA@1224|Proteobacteria,1RP0X@1236|Gammaproteobacteria,1WWQG@135613|Chromatiales 135613|Chromatiales M PFAM secretion protein HlyD - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_136436_1 749222.Nitsa_0843 5.47e-69 224.0 COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,42NH5@68525|delta/epsilon subdivisions,2YMK5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member - - - - - - - - - - - - Herpes_Helicase,PIF1 k59_1018541_1 83219.PM02_09370 3.38e-12 65.1 COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,2TST9@28211|Alphaproteobacteria,3ZVIU@60136|Sulfitobacter 28211|Alphaproteobacteria G pfkB family carbohydrate kinase frk - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_1018541_2 1208323.B30_11847 4.82e-56 188.0 COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,2TRBE@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Mannitol dehydrogenase mtlK - 1.1.1.57,1.1.1.67 ko:K00040,ko:K00045 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00061 R00868,R02454 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_463442_1 1150621.SMUL_2538 8.2e-75 236.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,42MN7@68525|delta/epsilon subdivisions,2YN3I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_463442_2 326298.Suden_1219 6.24e-11 61.6 COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,42Q5Q@68525|delta/epsilon subdivisions,2YNTB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S KR domain - - - - - - - - - - - - adh_short k59_626236_1 1174528.JH992898_gene4290 1.37e-09 62.8 COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1G46J@1117|Cyanobacteria,1JH02@1189|Stigonemataceae 1117|Cyanobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c,HisKA,PAS_9 k59_952986_1 1249480.B649_09220 4.3e-46 169.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2YMF5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent CLP protease ATP-binding subunit clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_429561_1 1034345.CAEM01000006_gene1341 1.04e-112 351.0 COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4CV6C@84998|Coriobacteriia 84998|Coriobacteriia O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_696312_1 566466.NOR53_2438 4.48e-50 174.0 COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria,1S21B@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Carbohydrate-selective porin OprB - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_598696_1 1123318.KB904589_gene941 1.29e-17 81.3 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 - - - ko:K12997 - - - - ko00000,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_2 k59_827145_1 1121403.AUCV01000004_gene2010 3.51e-90 274.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,42P2E@68525|delta/epsilon subdivisions,2WIJQ@28221|Deltaproteobacteria,2MIZC@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_566154_1 1123326.JFBL01000005_gene1140 1.67e-119 358.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42NYV@68525|delta/epsilon subdivisions,2YN1D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_925933_1 1123276.KB893272_gene2436 1.01e-128 383.0 COG3385@1|root,COG3385@2|Bacteria,4P02Y@976|Bacteroidetes,47TUA@768503|Cytophagia 976|Bacteroidetes L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_957579_1 1265505.ATUG01000002_gene2191 1.06e-66 220.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2MIFG@213118|Desulfobacterales 28221|Deltaproteobacteria P Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_827149_1 1121939.L861_05420 1.44e-49 169.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1XHTS@135619|Oceanospirillales 135619|Oceanospirillales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine - - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_827149_2 1504672.669786476 2.85e-59 192.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,2VI8F@28216|Betaproteobacteria,4AC0W@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_598714_1 1565314.OA34_09320 9.5e-56 186.0 COG0426@1|root,COG0426@2|Bacteria,1NDXY@1224|Proteobacteria,42N11@68525|delta/epsilon subdivisions,2YNA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Metallo-beta-lactamase superfamily - - 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B k59_467980_1 1165841.SULAR_10014 6.71e-12 65.1 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2YMVS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C k59_467980_2 387093.SUN_0188 1.14e-89 263.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,42SD5@68525|delta/epsilon subdivisions,2YP70@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_467980_3 1165841.SULAR_10004 5.71e-32 113.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2YP80@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_41363_2 572544.Ilyop_1340 5.87e-127 371.0 COG2233@1|root,COG2233@2|Bacteria,378C9@32066|Fusobacteria 32066|Fusobacteria F Permease family pyrP - - ko:K02824 - - - - ko00000,ko02000 2.A.40.1.1,2.A.40.1.2 - - Xan_ur_permease k59_401983_1 572544.Ilyop_1549 2.35e-101 312.0 COG1032@1|root,COG1032@2|Bacteria,378ST@32066|Fusobacteria 32066|Fusobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_174006_1 439235.Dalk_4744 1.59e-56 190.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,2MICX@213118|Desulfobacterales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_566166_1 1168034.FH5T_12095 3.45e-94 295.0 COG0317@1|root,COG0317@2|Bacteria,4NESY@976|Bacteroidetes,2FMEE@200643|Bacteroidia 976|Bacteroidetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_827153_2 709032.Sulku_2013 5.11e-53 169.0 COG1433@1|root,COG1433@2|Bacteria,1RDPR@1224|Proteobacteria,42UYN@68525|delta/epsilon subdivisions,2YPWH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_957591_1 765911.Thivi_3114 4.34e-135 392.0 COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,1RYIC@1236|Gammaproteobacteria,1WY81@135613|Chromatiales 135613|Chromatiales C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388,ko:K16885 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored k59_434156_1 1430440.MGMSRv2_4090 3.32e-75 240.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,2TU8A@28211|Alphaproteobacteria,2JQW5@204441|Rhodospirillales 204441|Rhodospirillales F Na+ dependent nucleoside transporter C-terminus - - - ko:K03317 - - - - ko00000 2.A.41 - - Nucleos_tra2_C,Nucleos_tra2_N k59_206499_1 927658.AJUM01000043_gene792 6.92e-79 254.0 COG5107@1|root,COG5107@2|Bacteria,4NEPG@976|Bacteroidetes,2FNHC@200643|Bacteroidia,3XIXI@558415|Marinilabiliaceae 976|Bacteroidetes A Domain of Unknown Function (DUF349) - - - - - - - - - - - - DUF349 k59_925947_1 1121403.AUCV01000031_gene2814 5.2e-20 87.4 COG0864@1|root,COG0864@2|Bacteria,1RDN6@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator nikR - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_270612_1 395492.Rleg2_2345 1.74e-07 52.0 COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2U0DV@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ADP-ribosylglycohydrolase draG - 3.2.2.24 ko:K05521 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH,Inositol_P k59_270612_2 1121904.ARBP01000013_gene455 3.74e-39 151.0 COG0653@1|root,COG0653@2|Bacteria 2|Bacteria U protein targeting secA2 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009405,GO:0009605,GO:0009607,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0035821,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043207,GO:0043492,GO:0043952,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0075136,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind,SecA_SW k59_957596_1 1280689.AUJC01000003_gene1283 4.16e-16 77.4 COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,36E7R@31979|Clostridiaceae 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_957596_2 572544.Ilyop_1728 3.41e-85 257.0 COG4399@1|root,COG4399@2|Bacteria,37A4K@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF445 k59_957596_3 572544.Ilyop_1734 1.13e-77 248.0 COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,378DH@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 k59_41374_1 1238190.AMQY01000025_gene106 3.04e-128 385.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XI3G@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_925958_1 1408813.AYMG01000023_gene2157 1.79e-07 55.8 COG1629@1|root,COG4771@2|Bacteria,4PN3U@976|Bacteroidetes 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 k59_925958_2 1168034.FH5T_19425 2.18e-13 70.5 COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,2FQ2H@200643|Bacteroidia 976|Bacteroidetes S Peptidase family M49 - - - - - - - - - - - - Peptidase_M49 k59_270620_1 314285.KT71_02892 1.84e-72 236.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1J7SK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_303292_1 1453505.JASY01000001_gene3646 7.92e-31 118.0 COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,1HZ28@117743|Flavobacteriia,2NZZR@237|Flavobacterium 976|Bacteroidetes L Integrase core domain - - - - - - - - - - - - rve,rve_3 k59_925961_1 1537917.JU82_05320 1.74e-88 281.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2YN1V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_957601_2 1168034.FH5T_17475 5.67e-136 389.0 COG1652@1|root,COG1652@2|Bacteria,4NJV3@976|Bacteroidetes,2FQP2@200643|Bacteroidia 976|Bacteroidetes S LysM domain - - - - - - - - - - - - - k59_957601_3 1168034.FH5T_17480 9.51e-61 202.0 COG3501@1|root,COG3501@2|Bacteria,4NFPB@976|Bacteroidetes,2FPUE@200643|Bacteroidia 976|Bacteroidetes S Rhs element Vgr protein - - - - - - - - - - - - Phage_GPD k59_892413_1 439235.Dalk_4515 3.89e-125 374.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_827175_2 1033737.CAEV01000005_gene2661 5.97e-102 307.0 COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,36EGU@31979|Clostridiaceae 186801|Clostridia E Belongs to the Glu Leu Phe Val dehydrogenases family gdh GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0071704,GO:1901564 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_402012_1 387093.SUN_1985 1.31e-88 276.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2YMVT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FP Guanosine pentaphosphate phosphohydrolase gppA - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_664539_1 722419.PH505_cc00040 1.33e-56 196.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,2Q0RI@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_892421_1 631362.Thi970DRAFT_01234 4.82e-97 295.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1WX8S@135613|Chromatiales 135613|Chromatiales P PFAM phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_566204_1 1168034.FH5T_05455 6.51e-60 196.0 COG2204@1|root,COG2204@2|Bacteria,4NDWI@976|Bacteroidetes,2FMNM@200643|Bacteroidia 976|Bacteroidetes K Sigma-54 interaction domain protein fhlA - - - - - - - - - - - HTH_8,Sigma54_activat k59_566204_2 1168034.FH5T_05450 7.43e-08 52.4 2CADI@1|root,32RR7@2|Bacteria,4NP51@976|Bacteroidetes,2FSVU@200643|Bacteroidia 976|Bacteroidetes S COG NOG14471 non supervised orthologous group lptE - - - - - - - - - - - LptE k59_206535_1 1380391.JIAS01000013_gene3407 3.59e-32 127.0 COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,2U1IH@28211|Alphaproteobacteria,2JPW1@204441|Rhodospirillales 204441|Rhodospirillales S Protein conserved in bacteria - - - - - - - - - - - - DUF2219 k59_270633_1 379731.PST_0125 1.6e-71 238.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1Z2EC@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NU General secretion pathway protein E gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_270633_2 926550.CLDAP_24460 3.23e-07 54.3 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG1609@1|root,COG2207@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG1609@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria 2|Bacteria K Transcriptional regulator - - - ko:K02529,ko:K07506 - - - - ko00000,ko03000 - - - AraC_binding,Cupin_2,HATPase_c,HTH_18,HisKA,Peripla_BP_3,Response_reg k59_925981_1 358220.C380_18880 2.77e-09 60.5 2DBXD@1|root,2ZBP6@2|Bacteria,1RB44@1224|Proteobacteria,2VQT3@28216|Betaproteobacteria,4ADT6@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3305) - - - - - - - - - - - - DUF3305 k59_533969_1 469618.FVAG_02714 1.96e-16 73.6 COG0335@1|root,COG0335@2|Bacteria,37A44@32066|Fusobacteria 32066|Fusobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_533969_3 457396.CSBG_03538 5.06e-92 273.0 COG1592@1|root,COG1592@2|Bacteria,1TSUY@1239|Firmicutes,248GY@186801|Clostridia,36EFS@31979|Clostridiaceae 186801|Clostridia C Rubrerythrin rbr3A GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005506,GO:0006091,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009266,GO:0009268,GO:0009408,GO:0009409,GO:0009628,GO:0009636,GO:0009651,GO:0009987,GO:0010035,GO:0010446,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0016999,GO:0017001,GO:0017144,GO:0022900,GO:0033554,GO:0034599,GO:0034605,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070417,GO:0070482,GO:0070887,GO:0071214,GO:0071236,GO:0071453,GO:0071467,GO:0071469,GO:0071470,GO:0071472,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:0104004,GO:1901700,GO:1901701,GO:1990748 - - - - - - - - - - Rubrerythrin k59_402023_1 794846.AJQU01000107_gene5257 2.09e-123 379.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,4B8CP@82115|Rhizobiaceae 28211|Alphaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_174057_1 1206777.B195_18749 4.39e-18 83.2 COG1879@1|root,COG1879@2|Bacteria,1MWGU@1224|Proteobacteria,1RQ56@1236|Gammaproteobacteria,1Z4M3@136849|Pseudomonas syringae group 1236|Gammaproteobacteria G ABC transporter, periplasmic - - - ko:K17213 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 k59_174057_2 1319815.HMPREF0202_00724 1.76e-22 92.0 29IC7@1|root,3059E@2|Bacteria,37AAR@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_827190_1 479435.Kfla_7052 1.09e-05 50.4 COG0454@1|root,COG0456@2|Bacteria,2IFF2@201174|Actinobacteria,4DRMU@85009|Propionibacteriales 201174|Actinobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_598774_1 1165841.SULAR_06768 1.51e-105 328.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2YM9V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_501212_1 1168034.FH5T_17870 5.47e-67 225.0 COG1042@1|root,COG1042@2|Bacteria,4NFTI@976|Bacteroidetes,2FNSJ@200643|Bacteroidia 976|Bacteroidetes C CoA binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_892440_1 665571.STHERM_c21570 3.12e-105 322.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J5JF@203691|Spirochaetes 203691|Spirochaetes C Oxaloacetate decarboxylase, alpha subunit oadA - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_1022966_1 1168034.FH5T_04985 3.94e-61 190.0 COG0102@1|root,COG0102@2|Bacteria,4NNGA@976|Bacteroidetes,2FS3I@200643|Bacteroidia 976|Bacteroidetes J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_1022966_2 1408473.JHXO01000001_gene1953 1.85e-47 154.0 COG0103@1|root,COG0103@2|Bacteria,4NNN1@976|Bacteroidetes,2FSGZ@200643|Bacteroidia 976|Bacteroidetes J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_338055_1 557598.LHK_01830 1.81e-07 58.5 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,2KPDI@206351|Neisseriales 206351|Neisseriales M Transporter, small conductance mechanosensitive ion channel MscS family protein aefA - - - - - - - - - - - MS_channel k59_501227_1 1472716.KBK24_0118645 3.56e-69 231.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VM2H@28216|Betaproteobacteria,1K0UN@119060|Burkholderiaceae 28216|Betaproteobacteria L helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_174078_1 1435356.Y013_13580 2.53e-15 79.7 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,2I3N3@201174|Actinobacteria,4FZA5@85025|Nocardiaceae 201174|Actinobacteria C Oxidoreductase FAD-binding domain - - 1.17.1.1,1.18.1.3 ko:K00523,ko:K00529,ko:K02639,ko:K16246 ko00071,ko00195,ko00360,ko00361,ko00362,ko00520,ko00623,ko01100,ko01120,ko01220,map00071,map00195,map00360,map00361,map00362,map00520,map00623,map01100,map01120,map01220 M00545,M00548 R02000,R03391,R03392,R03560,R03608,R06782,R06783,R10042,R10043 RC00046,RC00098,RC00230,RC00490 br01602,ko00000,ko00001,ko00002,ko00194,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_696400_1 709032.Sulku_1209 6.71e-85 273.0 COG0419@1|root,COG0419@2|Bacteria,1Q57D@1224|Proteobacteria,42NIY@68525|delta/epsilon subdivisions,2YNHQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L P-loop containing region of AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_859412_2 1163617.SCD_n01981 9.7e-34 127.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2VJZJ@28216|Betaproteobacteria 28216|Betaproteobacteria C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_957646_1 380703.AHA_2883 7.32e-66 212.0 COG0463@1|root,COG0463@2|Bacteria,1RA3F@1224|Proteobacteria,1T24F@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.305 ko:K16698,ko:K21363 - - - - ko00000,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_2 k59_957646_2 1165841.SULAR_10479 6.28e-13 68.6 COG1287@1|root,COG1287@2|Bacteria,1R8YG@1224|Proteobacteria,43BIB@68525|delta/epsilon subdivisions,2YT8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Oligosaccharide transferase - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_468044_1 709032.Sulku_1206 5.52e-05 53.9 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2YNEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - HCBP_related,HemolysinCabind,Laminin_G_3 k59_827210_1 398720.MED217_08780 2.5e-22 96.3 COG0702@1|root,COG0702@2|Bacteria,4PHW1@976|Bacteroidetes,1I7IZ@117743|Flavobacteriia,2XKFG@283735|Leeuwenhoekiella 976|Bacteroidetes GM SusD family - - - - - - - - - - - - SusD-like_3,SusD_RagB k59_827210_2 1134474.O59_002338 1.04e-55 184.0 2A5Y1@1|root,30UQ2@2|Bacteria,1RDC7@1224|Proteobacteria,1RWED@1236|Gammaproteobacteria,1FI0T@10|Cellvibrio 1236|Gammaproteobacteria S Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_827213_1 523794.Lebu_1700 2.58e-86 265.0 COG0468@1|root,COG0468@2|Bacteria,378P2@32066|Fusobacteria 32066|Fusobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_402055_1 326298.Suden_1213 3.45e-82 256.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42QN4@68525|delta/epsilon subdivisions,2YTQA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_728629_1 572544.Ilyop_1856 6.76e-60 197.0 COG0771@1|root,COG0771@2|Bacteria,378DR@32066|Fusobacteria 32066|Fusobacteria D Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_109315_1 243233.MCA1634 0.0 1102.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1XEDA@135618|Methylococcales 135618|Methylococcales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_566884_1 1158338.JNLJ01000001_gene865 1.89e-39 144.0 COG4424@1|root,COG4424@2|Bacteria,2G5AC@200783|Aquificae 200783|Aquificae S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_239495_1 269482.Bcep1808_2243 3.78e-64 209.0 COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2VK8A@28216|Betaproteobacteria,1JZYP@119060|Burkholderiaceae 28216|Betaproteobacteria F Imidazolone-5-propionate hydrolase hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_697054_1 469381.Dpep_2374 1.15e-66 215.0 COG3039@1|root,COG3039@2|Bacteria,3TBCF@508458|Synergistetes 508458|Synergistetes L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_402681_1 1249480.B649_01950 3.27e-38 132.0 COG4232@1|root,COG4232@2|Bacteria,1QZNE@1224|Proteobacteria,42W3P@68525|delta/epsilon subdivisions,2YQC9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredoxin_2,Thioredoxin_7 k59_958257_1 1385935.N836_33920 1.39e-24 109.0 COG2905@1|root,COG5001@1|root,COG2905@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1H9V4@1150|Oscillatoriales 1117|Cyanobacteria T Diguanylate cyclase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS_4,PAS_9 k59_434837_1 944547.ABLL_2114 2.34e-30 120.0 COG4774@1|root,COG4774@2|Bacteria,1QU2Y@1224|Proteobacteria,43CFU@68525|delta/epsilon subdivisions,2YTF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M PFAM TonB-dependent Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - TonB_dep_Rec k59_434837_2 478741.JAFS01000001_gene1661 4.61e-29 110.0 COG2346@1|root,COG2346@2|Bacteria,46YQ2@74201|Verrucomicrobia,37GPG@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_893112_1 572544.Ilyop_0657 2.01e-69 217.0 COG3394@1|root,COG3394@2|Bacteria,37CA3@32066|Fusobacteria 32066|Fusobacteria G PFAM YdjC family protein - - 3.5.1.105 ko:K03478 - - - - ko00000,ko01000 - - - YdjC k59_893112_2 545697.HMPREF0216_01019 1.38e-120 354.0 COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,249SY@186801|Clostridia,36EPM@31979|Clostridiaceae 186801|Clostridia I Lipid kinase dagK - 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_cat k59_893112_3 748727.CLJU_c02840 1.16e-187 543.0 COG0441@1|root,COG0572@1|root,COG0441@2|Bacteria,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,36DT4@31979|Clostridiaceae 186801|Clostridia F uridine kinase udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK k59_893112_4 1319815.HMPREF0202_00272 2.87e-92 287.0 COG0592@1|root,COG0592@2|Bacteria,3797W@32066|Fusobacteria 32066|Fusobacteria L DNA polymerase III beta subunit - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_728930_1 1168034.FH5T_12715 2.07e-87 275.0 COG0369@1|root,COG0369@2|Bacteria,4NHR8@976|Bacteroidetes,2FR5G@200643|Bacteroidia 976|Bacteroidetes P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component cysJ - 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_1,Flavodoxin_1,NAD_binding_1 k59_599484_1 439235.Dalk_0679 0.00084 47.4 COG2069@1|root,COG2069@2|Bacteria,1QS8G@1224|Proteobacteria,437H2@68525|delta/epsilon subdivisions,2WKVX@28221|Deltaproteobacteria,2MI1T@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM CO dehydrogenase acetyl-CoA synthase delta subunit - - 2.1.1.245 ko:K00194 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD k59_370739_1 990073.ATHU01000001_gene1762 4.37e-44 149.0 COG3864@1|root,COG3864@2|Bacteria,1Q995@1224|Proteobacteria,42YHV@68525|delta/epsilon subdivisions,2YRK9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N k59_697061_1 1168034.FH5T_15445 4.93e-82 256.0 COG3004@1|root,COG3004@2|Bacteria,4NFC4@976|Bacteroidetes,2FMP4@200643|Bacteroidia 976|Bacteroidetes P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1023611_1 1249480.B649_10815 4.14e-27 106.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2YM93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_1023611_2 1537917.JU82_01810 7.07e-70 215.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2YMCY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_604662_2 713587.THITH_10345 4.91e-94 278.0 COG1143@1|root,COG1143@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00338,ko:K02573 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_7 k59_767192_1 1415778.JQMM01000001_gene902 8.92e-05 44.3 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1J5ZF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Acetyl-coenzyme A transporter 1 ampG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015835,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1902600 - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_767192_2 1384056.N787_12570 2.95e-29 111.0 2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1X82G@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4426) - - - - - - - - - - - - DUF4426 k59_767192_3 555778.Hneap_1838 9.45e-08 52.8 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1WXC6@135613|Chromatiales 135613|Chromatiales S integral membrane protein - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_343775_1 243365.CV_3042 4.01e-55 180.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2VJRD@28216|Betaproteobacteria,2KPCA@206351|Neisseriales 206351|Neisseriales F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_343775_2 765910.MARPU_04880 5.76e-40 143.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1WWQK@135613|Chromatiales 135613|Chromatiales E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_244071_1 1385521.N803_00480 1.37e-11 69.7 COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4FFEV@85021|Intrasporangiaceae 201174|Actinobacteria S Transporter associated domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_571452_1 877455.Metbo_0711 6.22e-115 346.0 COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota 28890|Euryarchaeota E PFAM Aminotransferase class I and II - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_931342_1 395493.BegalDRAFT_0392 6.04e-05 44.3 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU twitching motility protein uptC - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_931342_2 1031711.RSPO_c02362 3.04e-117 343.0 COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VQDW@28216|Betaproteobacteria 28216|Betaproteobacteria L ISXO2-like transposase domain - - - ko:K07488 - - - - ko00000 - - - DDE_Tnp_IS1595 k59_80698_1 446466.Cfla_2528 1.82e-106 317.0 COG0538@1|root,COG0538@2|Bacteria,2GM3D@201174|Actinobacteria,4F2C9@85016|Cellulomonadaceae 201174|Actinobacteria C Belongs to the isocitrate and isopropylmalate dehydrogenases family icd GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_147504_1 572544.Ilyop_1242 2.08e-29 115.0 COG4591@1|root,COG4591@2|Bacteria 2|Bacteria M lipoprotein localization to outer membrane - - - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD k59_147504_2 215803.DB30_3633 1.36e-73 230.0 COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria 1224|Proteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_147504_4 1121324.CLIT_11c00720 5.88e-38 139.0 COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,249UE@186801|Clostridia,25TP9@186804|Peptostreptococcaceae 186801|Clostridia M NlpC/P60 family - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - NLPC_P60,SH3_3 k59_147505_1 572477.Alvin_1317 2.51e-86 279.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1SYHR@1236|Gammaproteobacteria,1WZZ5@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_80702_1 1283283.ATXA01000003_gene1511 8.92e-30 121.0 COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4ETRV@85013|Frankiales 201174|Actinobacteria E Pyridoxal-dependent decarboxylase conserved domain tdcA - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC k59_767214_1 1191523.MROS_1775 4.6e-87 259.0 COG0437@1|root,COG0437@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding nrfC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809 - ko:K04014,ko:K08353,ko:K08358,ko:K16293 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10149,R10150 RC02823,RC03109 ko00000,ko00001,ko02000 5.A.3.10,5.A.3.5 - iUMNK88_1353.UMNK88_4933 Fer4,Fer4_11,Fer4_3,Fer4_4 k59_897996_1 1122603.ATVI01000010_gene1015 1.51e-27 104.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1X67R@135614|Xanthomonadales 135614|Xanthomonadales I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_897996_2 2342.SOPEG_3691 6.04e-77 242.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria 1236|Gammaproteobacteria I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_963327_1 1321778.HMPREF1982_04002 3.54e-06 48.1 COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,267M7@186813|unclassified Clostridiales 186801|Clostridia K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_963327_2 742733.HMPREF9469_02223 3.07e-22 97.8 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,21XWS@1506553|Lachnoclostridium 186801|Clostridia O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_931354_1 1121918.ARWE01000001_gene2334 1.1e-36 135.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2WJRU@28221|Deltaproteobacteria,43S52@69541|Desulfuromonadales 28221|Deltaproteobacteria F Glycosyl transferase family, helical bundle domain trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2495 GATase,Glycos_trans_3N,Glycos_transf_3 k59_931354_2 1256908.HMPREF0373_01641 3.31e-83 251.0 COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,25VZ2@186806|Eubacteriaceae 186801|Clostridia EH Peptidase C26 trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_931354_3 521674.Plim_0761 4.61e-24 101.0 COG0147@1|root,COG0147@2|Bacteria,2IX6Q@203682|Planctomycetes 203682|Planctomycetes H Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_113723_1 1417296.U879_08050 3.84e-11 63.2 COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria,2U1YU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Radical SAM - - - ko:K09711 - - - - ko00000 - - - Radical_SAM k59_113723_2 582899.Hden_0685 3.92e-43 152.0 COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,2U4HP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Radical SAM - - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_10330_1 1137281.D778_01717 3.82e-06 54.3 COG0457@1|root,COG0457@2|Bacteria,4NH2K@976|Bacteroidetes,1I1JW@117743|Flavobacteriia 976|Bacteroidetes H tetratricopeptide repeat batC - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_46352_1 1026882.MAMP_01800 1.44e-106 322.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,45ZXN@72273|Thiotrichales 72273|Thiotrichales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_375215_1 1249975.JQLP01000008_gene307 1.85e-91 275.0 2AD5Y@1|root,312UK@2|Bacteria,4NV3M@976|Bacteroidetes,1IIGM@117743|Flavobacteriia 976|Bacteroidetes S FRG - - - - - - - - - - - - FRG k59_604704_1 1209072.ALBT01000058_gene932 8.72e-23 107.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_637820_1 926556.Echvi_3589 3.32e-31 132.0 COG3299@1|root,COG3299@2|Bacteria,4NF69@976|Bacteroidetes,47N9M@768503|Cytophagia 976|Bacteroidetes S homolog of phage Mu protein gp47 - - - - - - - - - - - - Baseplate_J k59_408159_1 1049564.TevJSym_ac01320 1.2e-07 51.2 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1J68X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 - ko:K03664 - - - - ko00000 - - - SmpB k59_997350_1 1304885.AUEY01000048_gene607 1.2e-39 154.0 COG0726@1|root,COG2373@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG0726@2|Bacteria,COG2373@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins lapA - - ko:K12549,ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Cadherin_3,Calx-beta,HemolysinCabind,VWA,VWA_2 k59_276006_1 1266925.JHVX01000013_gene1665 1.92e-63 218.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,372H6@32003|Nitrosomonadales 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_833387_1 933262.AXAM01000052_gene2019 2.71e-92 276.0 2CAZH@1|root,2Z7RU@2|Bacteria,1RBDC@1224|Proteobacteria,42SC7@68525|delta/epsilon subdivisions,2WP8S@28221|Deltaproteobacteria,2MJFJ@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family frdC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_213182_2 1453501.JELR01000001_gene3194 8.8e-30 116.0 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,1SEDW@1236|Gammaproteobacteria,46943@72275|Alteromonadaceae 1236|Gammaproteobacteria O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_180754_1 477184.KYC_24182 3.02e-13 73.9 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,2VHHM@28216|Betaproteobacteria 28216|Betaproteobacteria KLT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase k59_81452_1 1166018.FAES_2400 3.78e-11 66.2 COG4206@1|root,COG4206@2|Bacteria,4PMT5@976|Bacteroidetes,47YRX@768503|Cytophagia 976|Bacteroidetes H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_81452_2 1048983.EL17_00250 4.19e-05 52.8 COG0702@1|root,COG0702@2|Bacteria,4NHVQ@976|Bacteroidetes,47JBM@768503|Cytophagia 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_964128_1 153496.JNAB01000011_gene165 8.1e-74 233.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,2JPSN@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_81460_1 439235.Dalk_3051 2.54e-81 252.0 COG4637@1|root,COG4637@2|Bacteria,1RGAN@1224|Proteobacteria,42RZ9@68525|delta/epsilon subdivisions,2WNWP@28221|Deltaproteobacteria 28221|Deltaproteobacteria S AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_21 k59_473387_1 572544.Ilyop_0425 2.37e-118 358.0 COG0322@1|root,COG0322@2|Bacteria,378EP@32066|Fusobacteria 32066|Fusobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_473387_2 572544.Ilyop_0426 1.89e-51 165.0 COG0745@1|root,COG0745@2|Bacteria,37CWG@32066|Fusobacteria 32066|Fusobacteria T PFAM response regulator receiver - - - ko:K02490,ko:K03413 ko02020,ko02024,ko02030,map02020,map02024,map02030 M00485,M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_473387_3 469618.FVAG_01815 3.41e-178 517.0 COG2208@1|root,COG2208@2|Bacteria,378YN@32066|Fusobacteria 32066|Fusobacteria KT PFAM Stage II sporulation E family protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GAF_3,Response_reg,SpoIIE k59_81461_1 339670.Bamb_1819 4.11e-05 47.0 COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2VJI2@28216|Betaproteobacteria,1K0SM@119060|Burkholderiaceae 28216|Betaproteobacteria EJ Belongs to the asparaginase 1 family ansB - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_81461_2 634500.EbC_05500 5.77e-37 139.0 COG0436@1|root,COG0436@2|Bacteria,1QE0D@1224|Proteobacteria,1RZ3C@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate asdA - 4.1.1.12 ko:K09758 ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230 - R00397,R00863 RC00282,RC00399,RC00400 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_276027_1 315750.BPUM_3298 1.62e-81 252.0 COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H9WY@91061|Bacilli,1ZB2E@1386|Bacillus 91061|Bacilli E COG1126 ABC-type polar amino acid transport system, ATPase component glnQ2 - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_276027_2 861452.HMPREF9093_00597 2.33e-77 234.0 COG0054@1|root,COG0054@2|Bacteria,379ZU@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_276027_3 469618.FVAG_01390 1.63e-166 476.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,378FZ@32066|Fusobacteria 32066|Fusobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_276027_4 1408439.JHXW01000002_gene486 3.01e-09 56.2 COG0307@1|root,COG0307@2|Bacteria,37993@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_702770_1 1298867.AUES01000059_gene4745 4.18e-24 103.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2TU9Q@28211|Alphaproteobacteria,3JW1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_702770_2 102232.GLO73106DRAFT_00009750 3.64e-25 104.0 COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria 1117|Cyanobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_309580_1 187272.Mlg_1297 6e-155 452.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aldehyde ferredoxin oxidoreductase ydhV GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0030151,GO:0033719,GO:0043167,GO:0043169,GO:0043546,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0097159,GO:1901363 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_572226_1 1121456.ATVA01000011_gene1859 2.27e-37 138.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,42P72@68525|delta/epsilon subdivisions,2WKRS@28221|Deltaproteobacteria,2MGQJ@213115|Desulfovibrionales 28221|Deltaproteobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding gyaR - 1.1.1.26 ko:K00015,ko:K15893 ko00260,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map01100,map01110,map01120,map01130,map01200 M00532 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_572226_3 1304888.ATWF01000001_gene2419 3.56e-35 125.0 COG1704@1|root,COG1704@2|Bacteria,2GFE4@200930|Deferribacteres 200930|Deferribacteres S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_865552_1 765912.Thimo_1819 2.05e-48 173.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales 135613|Chromatiales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_148242_1 1150621.SMUL_3063 7.73e-61 199.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2YN15@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Glycosyl hydrolase family 3 - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Amidase_2,Glyco_hydro_3 k59_213206_1 296591.Bpro_4334 2.86e-141 409.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,4ABVU@80864|Comamonadaceae 28216|Betaproteobacteria L Integrase, catalytic region - - - - - - - - - - - - HTH_38,rve k59_276054_2 367299.JOEE01000003_gene2896 6.5e-20 91.7 COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria,4FEME@85021|Intrasporangiaceae 201174|Actinobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_1028874_1 1442599.JAAN01000020_gene2517 1.54e-08 55.8 COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,1S5B7@1236|Gammaproteobacteria,1X6PQ@135614|Xanthomonadales 135614|Xanthomonadales S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_1028874_2 1532558.JL39_08180 1.63e-34 133.0 COG0477@1|root,COG0477@2|Bacteria,1QV6P@1224|Proteobacteria,2TX12@28211|Alphaproteobacteria,4BBGG@82115|Rhizobiaceae 28211|Alphaproteobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_114501_2 1408823.AXUS01000004_gene220 1.36e-23 97.8 COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,25SC0@186804|Peptostreptococcaceae 186801|Clostridia O peptidyl-prolyl isomerase prsA2 - 5.2.1.8 ko:K03769,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 k59_440400_1 709032.Sulku_2330 2.37e-144 416.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2YMD8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_670915_1 572477.Alvin_2212 1.31e-132 392.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_670915_2 945713.IALB_2154 6.89e-20 89.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_997385_1 1168034.FH5T_10790 2.74e-68 222.0 COG1190@1|root,COG1190@2|Bacteria,4NDZN@976|Bacteroidetes,2FMXC@200643|Bacteroidia 976|Bacteroidetes J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF4332,tRNA-synt_2,tRNA_anti-codon k59_276058_1 96561.Dole_2511 2.19e-49 176.0 COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Fe-S cluster domain protein - - - - - - - - - - - - FeS,Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3 k59_440419_2 699248.SRA_03676 2.03e-14 75.9 COG1061@1|root,COG3587@1|root,COG1061@2|Bacteria,COG3587@2|Bacteria 2|Bacteria L Type III restriction enzyme, res subunit resA - 3.1.21.5 ko:K01156 - - - - ko00000,ko01000,ko02048 - - - Helicase_C,ResIII k59_898826_2 983920.Y88_3523 2.82e-18 84.7 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2TR8G@28211|Alphaproteobacteria,2K22M@204457|Sphingomonadales 204457|Sphingomonadales M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_309593_1 1121405.dsmv_1984 1.48e-138 404.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MJG3@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_767969_1 1120983.KB894572_gene2776 3.96e-53 179.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TQN5@28211|Alphaproteobacteria,1JPP7@119043|Rhodobiaceae 28211|Alphaproteobacteria H AMP-binding enzyme MA20_42595 - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_865584_1 546271.Selsp_1910 4.38e-09 59.7 COG0589@1|root,COG0589@2|Bacteria,1U42B@1239|Firmicutes,4H7IH@909932|Negativicutes 909932|Negativicutes T Universal stress protein family - - - - - - - - - - - - Usp k59_767981_1 56780.SYN_01364 1.4e-23 105.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_833414_1 631362.Thi970DRAFT_01937 2.49e-70 224.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1WX6X@135613|Chromatiales 135613|Chromatiales C Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_767982_1 1165841.SULAR_00415 1.43e-70 223.0 COG1651@1|root,COG1651@2|Bacteria,1RFRJ@1224|Proteobacteria,42SPD@68525|delta/epsilon subdivisions,2YP88@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - - - - - - - - - - - Thioredoxin_4 k59_540337_1 697282.Mettu_0209 3.24e-11 70.5 COG3209@1|root,COG4447@1|root,COG3209@2|Bacteria,COG4447@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XGAS@135618|Methylococcales 135618|Methylococcales M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - RHS_repeat k59_446470_2 1279038.KB907341_gene1951 3.79e-90 276.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,2JPIZ@204441|Rhodospirillales 204441|Rhodospirillales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_154173_1 398720.MED217_15180 1.06e-49 164.0 COG2353@1|root,COG2353@2|Bacteria,4NNMD@976|Bacteroidetes,1I39B@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_186791_1 1249480.B649_08130 4.59e-68 228.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42UBD@68525|delta/epsilon subdivisions,2YRGP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T 7TM diverse intracellular signalling - - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c k59_514267_1 545243.BAEV01000028_gene674 4.18e-30 116.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,36EB1@31979|Clostridiaceae 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_514267_2 1121396.KB893058_gene2569 2.78e-115 338.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42NRB@68525|delta/epsilon subdivisions,2WJHF@28221|Deltaproteobacteria,2MJI6@213118|Desulfobacterales 28221|Deltaproteobacteria HP ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_970327_1 1123054.KB907706_gene2281 8.11e-66 213.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminotransferase aspC - 2.6.1.1,2.6.1.57 ko:K00813,ko:K00832 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 M00024,M00025,M00034,M00040 R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_708828_1 1118055.CAGU01000052_gene1867 6.92e-11 60.8 COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia,22HNC@1570339|Peptoniphilaceae 186801|Clostridia K Protein of unknown function (DUF448) ylxR - - ko:K07742 - - - - ko00000 - - - DUF448 k59_904838_1 159749.K0T4T6 2.56e-19 91.7 2EF9S@1|root,2T4ED@2759|Eukaryota,2XEWT@2836|Bacillariophyta 2836|Bacillariophyta - - - - - - - - - - - - - - - k59_708830_1 1499686.BN1079_01241 5.2e-52 185.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_708837_1 1283284.AZUK01000001_gene1202 1.02e-05 52.8 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1Y3FP@135624|Aeromonadales 135624|Aeromonadales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K12276 ko05111,map05111 - - - ko00000,ko00001,ko02044 - - - T2SSE,T2SSE_N k59_740258_1 572544.Ilyop_0883 3.07e-180 511.0 COG2108@1|root,COG2108@2|Bacteria,37BJB@32066|Fusobacteria 32066|Fusobacteria S Radical SAM superfamily - - - ko:K07129 - - - - ko00000 - - - Radical_SAM k59_740258_2 207559.Dde_2979 3.3e-26 106.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,42MSW@68525|delta/epsilon subdivisions,2WNY3@28221|Deltaproteobacteria,2M9RB@213115|Desulfovibrionales 28221|Deltaproteobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_1034684_1 519989.ECTPHS_07511 1.6e-19 95.1 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1X0CU@135613|Chromatiales 135613|Chromatiales H HemY domain protein - - - ko:K02498 - - - - ko00000 - - - HemY_N k59_1034684_2 225937.HP15_238 1.29e-22 105.0 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,467C6@72275|Alteromonadaceae 1236|Gammaproteobacteria H enzyme of heme biosynthesis hemX - 2.1.1.107,4.2.1.75 ko:K02496,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iPC815.YPO3851,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317 HemX k59_871491_1 765912.Thimo_0095 2.65e-08 52.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1WYH0@135613|Chromatiales 135613|Chromatiales K regulatory protein, arsR - - - - - - - - - - - - HTH_5 k59_871491_2 631362.Thi970DRAFT_00997 1.45e-114 337.0 COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1S0ZZ@1236|Gammaproteobacteria,1WX12@135613|Chromatiales 135613|Chromatiales KT response regulator receiver - - - - - - - - - - - - PAS,PAS_9,Response_reg k59_740261_1 768671.ThimaDRAFT_4596 1.79e-24 100.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria,1WWKB@135613|Chromatiales 135613|Chromatiales S PFAM Radical SAM - - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_740261_2 1249627.D779_2908 1.53e-36 132.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RP6X@1236|Gammaproteobacteria,1WWZ7@135613|Chromatiales 135613|Chromatiales O PFAM peptidase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_446479_1 56780.SYN_00568 9.02e-70 231.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_970336_2 1165841.SULAR_06343 2.32e-20 93.6 COG4967@1|root,COG4967@2|Bacteria 2|Bacteria NU type IV pilus modification protein PilV ppdC - - ko:K02458,ko:K02671,ko:K02681 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15 - - N_methyl,T2SSppdC k59_643909_1 768671.ThimaDRAFT_0802 9.15e-114 343.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVK@1236|Gammaproteobacteria,1X2B5@135613|Chromatiales 1236|Gammaproteobacteria NU PFAM Sulphatase-modifying factor - - - ko:K20333 ko02024,map02024 - - - ko00000,ko00001 - - - FGE-sulfatase,PEGA,Pkinase k59_643909_2 887898.HMPREF0551_1135 0.000907 41.2 COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria,1KBW0@119060|Burkholderiaceae 28216|Betaproteobacteria M HlyD family secretion protein - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_677248_1 326298.Suden_1929 3.85e-18 84.7 COG0790@1|root,COG0790@2|Bacteria,1NY7Z@1224|Proteobacteria,42T5I@68525|delta/epsilon subdivisions,2YPQ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0790 FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_17326_1 626887.J057_04065 4.26e-122 362.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,464AB@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_938053_1 1168034.FH5T_11010 5.13e-76 232.0 COG0847@1|root,COG0847@2|Bacteria,4NJRG@976|Bacteroidetes 976|Bacteroidetes L 3' exoribonuclease, RNase T-like - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_1034693_1 1168034.FH5T_00815 1.84e-37 139.0 COG3507@1|root,COG3507@2|Bacteria,4NFXE@976|Bacteroidetes,2FNGR@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family xynBA - - - - - - - - - - - Glyco_hydro_43 k59_1034693_2 1124780.ANNU01000008_gene2673 5.83e-61 195.0 COG2755@1|root,COG2755@2|Bacteria,4NKE5@976|Bacteroidetes,47KUH@768503|Cytophagia 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase rhgT_1 - - - - - - - - - - - Lipase_GDSL_2,Polysacc_deac_1 k59_315549_1 1168034.FH5T_21095 7.34e-56 177.0 COG0622@1|root,COG0622@2|Bacteria,4NM4G@976|Bacteroidetes,2FSMW@200643|Bacteroidia 976|Bacteroidetes S Phosphoesterase - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_315549_2 1244528.CFT03427_0877 3.16e-14 71.2 COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,42TJ0@68525|delta/epsilon subdivisions,2YPZ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T phosphohistidine phosphatase, SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_87664_1 768671.ThimaDRAFT_3829 1.11e-101 307.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WXET@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_8,RnfC_N,SLBB k59_708854_1 1150621.SMUL_0922 6.34e-41 140.0 COG1845@1|root,COG1845@2|Bacteria,1RI5A@1224|Proteobacteria,43B3F@68525|delta/epsilon subdivisions 1224|Proteobacteria C Cytochrome c oxidase subunit III coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_708854_2 1150621.SMUL_0923 9.31e-46 160.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions 1224|Proteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_282057_1 387093.SUN_1012 7.04e-52 176.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2YN0D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J MiaB-like tRNA modifying enzyme yqeV - - - - - - - - - - - Radical_SAM,UPF0004 k59_282057_2 387093.SUN_1011 3.44e-201 580.0 COG0668@1|root,COG0668@2|Bacteria,1PMY3@1224|Proteobacteria,42M4K@68525|delta/epsilon subdivisions,2YMAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_774078_1 1519464.HY22_02150 2.91e-106 328.0 COG0423@1|root,COG0423@2|Bacteria,1FDA0@1090|Chlorobi 1090|Chlorobi J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_315569_1 1163617.SCD_n02368 5.2e-218 617.0 COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,2VQU4@28216|Betaproteobacteria 28216|Betaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_677284_1 1047013.AQSP01000108_gene2059 1.47e-17 83.2 COG4635@1|root,COG4635@2|Bacteria,2NQ4K@2323|unclassified Bacteria 2|Bacteria CH Flavodoxin domain - - 1.3.5.3 ko:K00230 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R09489 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Flavodoxin_5,PCP_red,Putative_PNPOx k59_414111_1 469618.FVAG_02261 1.76e-158 447.0 COG2877@1|root,COG2877@2|Bacteria,3786I@32066|Fusobacteria 32066|Fusobacteria H 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_677291_1 96561.Dole_1461 2.43e-110 336.0 COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MINQ@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit - - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Prismane k59_1034731_1 1286631.X805_07550 3.58e-67 221.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,1KKB8@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_414114_1 876044.IMCC3088_747 1.7e-97 296.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,1J4BZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2333 k59_414116_1 391587.KAOT1_14817 4.28e-13 70.1 COG1194@1|root,COG1194@2|Bacteria,4NDZY@976|Bacteroidetes,1HY00@117743|Flavobacteriia 976|Bacteroidetes L a g-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_414116_2 983544.Lacal_1223 2.29e-44 146.0 COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,1I27K@117743|Flavobacteriia 976|Bacteroidetes L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_219385_1 743525.TSC_c02040 2.82e-30 120.0 COG1989@1|root,COG1989@2|Bacteria,1WIEB@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus NOU Type II secretory pathway, prepilin signal peptidase PulO and related - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_186864_2 311403.Arad_3928 8.36e-53 183.0 COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,2TR6B@28211|Alphaproteobacteria,4B9SF@82115|Rhizobiaceae 28211|Alphaproteobacteria S oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_677310_1 84531.JMTZ01000019_gene4023 7.45e-82 253.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1X3G9@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_446536_1 1355368.JART01000012_gene469 1.08e-94 287.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2YMID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_871528_1 396588.Tgr7_3209 9.32e-30 115.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1WWMC@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_871528_2 247633.GP2143_01062 6.32e-52 176.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1J4R8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_677311_1 1245471.PCA10_36070 1.19e-43 154.0 COG1752@1|root,COG1752@2|Bacteria,1MU6Z@1224|Proteobacteria,1RPW6@1236|Gammaproteobacteria,1YE7T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - Patatin k59_53084_1 445970.ALIPUT_00588 5.86e-97 308.0 COG0441@1|root,COG0441@2|Bacteria,4NEFT@976|Bacteroidetes,2FMAU@200643|Bacteroidia,22U2K@171550|Rikenellaceae 976|Bacteroidetes J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_803329_1 572477.Alvin_2487 2.29e-84 272.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMFB@1236|Gammaproteobacteria,1X2JU@135613|Chromatiales 135613|Chromatiales E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_677314_1 913325.N799_04650 1.17e-137 410.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_350540_1 498211.CJA_0728 5.54e-50 167.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1FH39@10|Cellvibrio 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_1003513_1 521000.PROVRETT_08466 5.11e-36 139.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,3Z7XC@586|Providencia 1236|Gammaproteobacteria E dehydrogenase I thrA GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K12524,ko:K12525 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0002,iEcDH1_1363.EcDH1_3594,iSFV_1184.SFV_0001 AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_938122_1 768670.Calni_0746 2.05e-36 138.0 COG1232@1|root,COG1232@2|Bacteria,2GF9H@200930|Deferribacteres 200930|Deferribacteres H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_545930_2 1280390.CBQR020000149_gene3838 1.76e-29 121.0 COG1116@1|root,COG4754@1|root,COG1116@2|Bacteria,COG4754@2|Bacteria,1TRM6@1239|Firmicutes,4HF9R@91061|Bacilli,26VA0@186822|Paenibacillaceae 91061|Bacilli P C-terminal AAA-associated domain - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - AAA_assoc_C,ABC_tran k59_545930_3 349161.Dred_0438 2.1e-42 151.0 COG0600@1|root,COG0600@2|Bacteria,1V73W@1239|Firmicutes,24A2R@186801|Clostridia 186801|Clostridia P Abc transporter, permease protein - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran,BPD_transp_1 k59_545930_4 1121423.JONT01000002_gene2295 1.54e-32 129.0 COG0715@1|root,COG0715@2|Bacteria,1TT2F@1239|Firmicutes,249M2@186801|Clostridia 186801|Clostridia P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_1003517_1 1123393.KB891317_gene2319 4.11e-68 211.0 COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2VQBM@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF1211) - - - - - - - - - - - - DUF1211 k59_1003517_2 1137799.GZ78_23230 0.000137 43.1 COG4445@1|root,COG4445@2|Bacteria,1MVFE@1224|Proteobacteria,1RQ8Z@1236|Gammaproteobacteria,1XIJ2@135619|Oceanospirillales 135619|Oceanospirillales FJ Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA miaE - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_219414_1 377629.TERTU_4019 1.07e-80 262.0 COG5297@1|root,COG5297@2|Bacteria,1QZ9W@1224|Proteobacteria,1RPFR@1236|Gammaproteobacteria,2PP89@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Glycosyl hydrolase family 9 - - - - - - - - - - - - CBM_2,Glyco_hydro_9 k59_871542_1 1121012.AUKX01000098_gene2633 5.15e-58 195.0 COG5421@1|root,COG5421@2|Bacteria,4PAGJ@976|Bacteroidetes,1IAIH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DDE_Tnp_1 k59_803339_1 999411.HMPREF1092_02827 5.42e-121 362.0 COG4468@1|root,COG4468@2|Bacteria,1TPBN@1239|Firmicutes,247ZN@186801|Clostridia,36DF1@31979|Clostridiaceae 186801|Clostridia G UDP-glucose--hexose-1-phosphate uridylyltransferase galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf k59_803339_2 572544.Ilyop_1681 5.93e-21 89.7 COG1087@1|root,COG1087@2|Bacteria,378JK@32066|Fusobacteria 32066|Fusobacteria M UDP-glucose 4-epimerase galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_611345_1 1353537.TP2_08945 3.73e-120 360.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,2XMUS@285107|Thioclava 28211|Alphaproteobacteria O required for the transfer of heme to apocytochrome c ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_381974_1 1121405.dsmv_2021 4.36e-81 261.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,2MI8Q@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_414150_1 331678.Cphamn1_0709 4.03e-115 349.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - ko:K06915 - - - - ko00000 - - - DUF87 k59_414150_2 56780.SYN_01823 2.43e-11 62.8 arCOG14100@1|root,30W0I@2|Bacteria,1PWET@1224|Proteobacteria,434BP@68525|delta/epsilon subdivisions,2WXEG@28221|Deltaproteobacteria,2MSB5@213462|Syntrophobacterales 28221|Deltaproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_53814_1 273121.WS0749 9.04e-150 432.0 COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1NTJT@1224|Proteobacteria,42NK8@68525|delta/epsilon subdivisions,2YNNU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM Cytochrome c, class I - - - - - - - - - - - - Cyt_bd_oxida_I,Cytochrome_CBB3 k59_741064_1 931276.Cspa_c40780 5.37e-47 164.0 COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,36F7N@31979|Clostridiaceae 186801|Clostridia C Belongs to the NiFe NiFeSe hydrogenase large subunit family hupL - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_741064_2 1262449.CP6013_0753 7.34e-113 335.0 COG1740@1|root,COG1740@2|Bacteria,1TZZD@1239|Firmicutes,2489B@186801|Clostridia,36EWC@31979|Clostridiaceae 186801|Clostridia C Hydrogenase (NiFe) small subunit HydA hupS - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_187581_2 243233.MCA3024 3.04e-86 260.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1XEH9@135618|Methylococcales 135618|Methylococcales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_971049_2 485915.Dret_2002 5.34e-65 210.0 COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,zf-ISL3 k59_872427_1 316274.Haur_4920 1.16e-10 59.7 COG0091@1|root,COG0091@2|Bacteria,2G6ZQ@200795|Chloroflexi,375TE@32061|Chloroflexia 32061|Chloroflexia J its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_872427_2 314287.GB2207_06158 9.31e-50 159.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1J68S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_872427_3 1123261.AXDW01000010_gene240 3.21e-89 269.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1X3GB@135614|Xanthomonadales 135614|Xanthomonadales J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_1004239_1 387093.SUN_0483 5.16e-38 131.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2YPGX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the Fur family fur GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_1004239_2 710393.HSUHS1_0067 3.47e-17 82.8 COG1286@1|root,COG1286@2|Bacteria,1RJE1@1224|Proteobacteria,42SCW@68525|delta/epsilon subdivisions 1224|Proteobacteria S PFAM Colicin V production protein cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_18034_1 370438.PTH_0686 3.38e-14 76.6 COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,2617B@186807|Peptococcaceae 186801|Clostridia O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_1035369_1 1249480.B649_11185 5.89e-87 269.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2YMQH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin biosynthesis moeA2 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_220068_1 1249627.D779_4058 8.39e-32 114.0 2BRPS@1|root,32KPD@2|Bacteria,1PAWY@1224|Proteobacteria,1STPX@1236|Gammaproteobacteria,1X1Q8@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_583383_2 1192034.CAP_1737 1.75e-49 172.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2YU5R@29|Myxococcales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_876369_1 396588.Tgr7_2113 2.82e-65 221.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_255818_1 1268240.ATFI01000001_gene2761 1.02e-67 233.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FW53@200643|Bacteroidia,4AWE5@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_942734_1 1249627.D779_0902 1.02e-18 84.3 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WXUC@135613|Chromatiales 135613|Chromatiales S ABC-type transport system involved in multi-copper enzyme maturation, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_942734_2 1131553.JIBI01000006_gene1116 8.92e-35 135.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria,37263@32003|Nitrosomonadales 28216|Betaproteobacteria N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_583387_1 749222.Nitsa_1731 3.41e-169 481.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2YMAG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1040165_1 709032.Sulku_1497 1.08e-113 340.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,42MNG@68525|delta/epsilon subdivisions,2YNM4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation - - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_551109_1 1158292.JPOE01000005_gene968 8.04e-13 65.9 2E7QP@1|root,33262@2|Bacteria,1N8VK@1224|Proteobacteria,2VYHA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_551109_2 1158292.JPOE01000005_gene967 9.89e-110 372.0 COG0286@1|root,COG0286@2|Bacteria,1NG8W@1224|Proteobacteria,2W1S5@28216|Betaproteobacteria 28216|Betaproteobacteria L N-6 DNA Methylase - - - - - - - - - - - - N6_Mtase k59_551109_4 266265.Bxe_B0861 3.86e-13 67.0 COG3636@1|root,COG3636@2|Bacteria,1N75D@1224|Proteobacteria,2VTZN@28216|Betaproteobacteria,1KHCW@119060|Burkholderiaceae 28216|Betaproteobacteria K addiction module antidote protein - - - - - - - - - - - - HTH_3 k59_551109_5 1117318.PRUB_15620 4.23e-30 131.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,2Q2B1@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG1520 FOG WD40-like repeat - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_744722_1 1501391.LG35_08100 4e-15 71.6 COG1670@1|root,COG1670@2|Bacteria,4NQ8K@976|Bacteroidetes,2FMII@200643|Bacteroidia,22UI5@171550|Rikenellaceae 976|Bacteroidetes J Acetyltransferase (GNAT) domain speG - 2.3.1.57 ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_3 k59_876380_1 314275.MADE_1008195 8.56e-07 55.1 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,1RQ8J@1236|Gammaproteobacteria,468KY@72275|Alteromonadaceae 1236|Gammaproteobacteria M Glycosyl transferases group 1 wcaL GO:0003674,GO:0003824,GO:0016740,GO:0016757 - ko:K16703 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_876380_2 748247.AZKH_0592 1.72e-20 87.4 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,2VQAV@28216|Betaproteobacteria 28216|Betaproteobacteria G polysaccharide deacetylase icaB - - - - - - - - - - - Polysacc_deac_1 k59_452051_1 314275.MADE_000001023090 3.96e-76 244.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,4640T@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_974677_1 1262449.CP6013_1783 3.28e-76 244.0 COG0644@1|root,COG0644@2|Bacteria,1UZT1@1239|Firmicutes,25DJ8@186801|Clostridia,36HJZ@31979|Clostridiaceae 186801|Clostridia C oxidoreductase cbrA - - - - - - - - - - - FAD_binding_3,Lycopene_cycl,NAD_binding_8 k59_519394_1 1280952.HJA_13220 1.5e-118 357.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases MA20_01050 - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_551122_1 1167006.UWK_00113 1.7e-70 236.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,42NB9@68525|delta/epsilon subdivisions,2WKTK@28221|Deltaproteobacteria,2MIXF@213118|Desulfobacterales 28221|Deltaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_387534_1 1198232.CYCME_0689 7.96e-27 105.0 COG0515@1|root,COG0515@2|Bacteria,1QU0D@1224|Proteobacteria,1T58D@1236|Gammaproteobacteria,462EW@72273|Thiotrichales 72273|Thiotrichales KLT Lipopolysaccharide kinase (Kdo/WaaP) family - - - - - - - - - - - - Kdo k59_387534_2 187272.Mlg_2794 9.26e-29 112.0 COG0515@1|root,COG0515@2|Bacteria,1MXX9@1224|Proteobacteria,1RQFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core rfaP GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 - ko:K02848 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF1260.b3630,iBWG_1329.BWG_3321,iEC042_1314.EC042_3937,iECDH10B_1368.ECDH10B_3812,iECDH1ME8569_1439.ECDH1ME8569_3515,iEcDH1_1363.EcDH1_0075,iJO1366.b3630,iY75_1357.Y75_RS18985 Kdo k59_159872_1 865861.AZSU01000009_gene635 2.72e-34 122.0 COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,24MN9@186801|Clostridia,36KRW@31979|Clostridiaceae 186801|Clostridia S protein with conserved CXXC pairs - - - - - - - - - - - - DUF1667 k59_159872_2 1121289.JHVL01000017_gene765 7.29e-33 125.0 COG0446@1|root,COG0446@2|Bacteria,1TQH5@1239|Firmicutes,247YR@186801|Clostridia,36DSF@31979|Clostridiaceae 186801|Clostridia C Oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_3 k59_58216_1 929558.SMGD1_2165 2.14e-25 95.1 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,42U8W@68525|delta/epsilon subdivisions,2YPVK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin fdxB - - ko:K05337 - - - - ko00000 - - - Fer4 k59_58216_2 563040.Saut_0689 2.99e-42 150.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ5@1224|Proteobacteria,42NJC@68525|delta/epsilon subdivisions,2YMGQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase cosS - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_942746_2 573413.Spirs_3322 3.75e-241 676.0 COG0591@1|root,COG0591@2|Bacteria,2J5R8@203691|Spirochaetes 203691|Spirochaetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_519409_1 84531.JMTZ01000032_gene288 1.35e-05 46.6 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1X381@135614|Xanthomonadales 135614|Xanthomonadales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_519409_2 1442599.JAAN01000005_gene915 4.93e-30 120.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1X30N@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_418585_1 1249480.B649_01175 5.4e-85 273.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 k59_909304_1 935567.JAES01000007_gene1900 0.000298 41.6 2E5FW@1|root,3307K@2|Bacteria,1R3G8@1224|Proteobacteria,1T67F@1236|Gammaproteobacteria,1X8M9@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1761) - - - - - - - - - - - - DUF1761 k59_909304_2 1168034.FH5T_10165 1.73e-110 329.0 COG1774@1|root,COG1774@2|Bacteria,4NENX@976|Bacteroidetes,2FNYP@200643|Bacteroidia 976|Bacteroidetes S PSP1 C-terminal domain protein yaaT - - - - - - - - - - - PSP1 k59_418586_2 1122135.KB893134_gene3281 1.2e-74 246.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_483394_1 1168034.FH5T_18910 2.39e-142 431.0 COG0823@1|root,COG0823@2|Bacteria,4NGPR@976|Bacteroidetes,2FNGJ@200643|Bacteroidia 976|Bacteroidetes U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - - k59_191690_1 338966.Ppro_1009 1.76e-57 192.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42T20@68525|delta/epsilon subdivisions,2WP7S@28221|Deltaproteobacteria,43W22@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_387543_1 1168034.FH5T_05160 3.73e-42 153.0 COG0437@1|root,COG0437@2|Bacteria,4NE5M@976|Bacteroidetes 976|Bacteroidetes C Quinol cytochrome c oxidoreductase nrfC - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molydop_binding k59_224822_2 318464.IO99_00735 1.79e-19 86.7 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,36DFS@31979|Clostridiaceae 186801|Clostridia M mannose-1-phosphate guanylyltransferase - - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_649434_1 572544.Ilyop_1535 1.09e-21 90.1 2CH3Z@1|root,32RP9@2|Bacteria,37B3Y@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF2721) - - - - - - - - - - - - DUF2721 k59_453074_1 1249480.B649_06610 1.78e-46 156.0 COG2077@1|root,COG2077@2|Bacteria,1Q5Y2@1224|Proteobacteria,4321Y@68525|delta/epsilon subdivisions,2YS92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides - - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - - k59_320464_2 714943.Mucpa_5701 1.63e-34 127.0 COG2801@1|root,COG2801@2|Bacteria,4NIBY@976|Bacteroidetes,1ITSB@117747|Sphingobacteriia 976|Bacteroidetes L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_287960_1 1168034.FH5T_08815 3.52e-85 279.0 COG1729@1|root,COG1729@2|Bacteria,4PKGA@976|Bacteroidetes,2G3G6@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 k59_1008611_1 760154.Sulba_0090 2.61e-35 130.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2YMC6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0566 DAP_epimerase k59_584240_1 768671.ThimaDRAFT_3386 3.4e-74 236.0 COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales 135613|Chromatiales O smart pdz dhr glgf - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_779583_1 471854.Dfer_0659 1.5e-64 212.0 COG0464@1|root,COG0464@2|Bacteria,4NFWG@976|Bacteroidetes,47MR8@768503|Cytophagia 976|Bacteroidetes O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_484230_1 631362.Thi970DRAFT_00761 7.93e-14 73.6 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1WWQS@135613|Chromatiales 135613|Chromatiales Q PFAM Mammalian cell entry related - - - ko:K06192 - - - - ko00000 - - - MlaD k59_388445_1 762982.HMPREF9442_03472 1.7e-17 87.0 COG2335@1|root,COG2335@2|Bacteria,4P1H9@976|Bacteroidetes,2FWCR@200643|Bacteroidia 976|Bacteroidetes M Fasciclin domain - - - - - - - - - - - - DUF4993,Fasciclin k59_160527_1 1168034.FH5T_03450 2.04e-134 399.0 COG0443@1|root,COG0443@2|Bacteria,4NERF@976|Bacteroidetes,2FMNH@200643|Bacteroidia 976|Bacteroidetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_160527_2 1168034.FH5T_03230 2.4e-53 170.0 2909P@1|root,2ZMZB@2|Bacteria,4P7H1@976|Bacteroidetes,2FZKU@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_616960_1 1396141.BATP01000054_gene2917 7.37e-76 255.0 COG1643@1|root,COG1643@2|Bacteria,46TFT@74201|Verrucomicrobia,2IU1J@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Oligonucleotide/oligosaccharide-binding (OB)-fold - - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_552208_1 1355368.JART01000017_gene2004 1.25e-83 272.0 28NCD@1|root,2ZBFF@2|Bacteria,1N51P@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_453091_1 1117647.M5M_17345 6.38e-20 89.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_453091_2 765913.ThidrDRAFT_2819 3.41e-31 116.0 COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,1S95S@1236|Gammaproteobacteria,1WYBS@135613|Chromatiales 135613|Chromatiales LU Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier k59_910147_1 216594.MMAR_2847 3.48e-26 104.0 2DQ16@1|root,334AZ@2|Bacteria,2IMJY@201174|Actinobacteria,23A9M@1762|Mycobacteriaceae 201174|Actinobacteria S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like k59_93335_1 525257.HMPREF0204_13633 2.03e-17 95.1 COG0323@1|root,COG0323@2|Bacteria,4PCY5@976|Bacteroidetes,1IN7G@117743|Flavobacteriia,3ZTER@59732|Chryseobacterium 976|Bacteroidetes L Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c_3 k59_355804_2 1454004.AW11_00301 1.71e-75 235.0 COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,2VN04@28216|Betaproteobacteria 28216|Betaproteobacteria G Fructosamine kinase - - - - - - - - - - - - Fructosamin_kin k59_388462_1 572544.Ilyop_1262 1.19e-102 308.0 COG0305@1|root,COG0305@2|Bacteria,3784X@32066|Fusobacteria 32066|Fusobacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_224855_1 574966.KB898652_gene1839 3.27e-53 180.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1XHPA@135619|Oceanospirillales 135619|Oceanospirillales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_484261_1 765910.MARPU_05100 1.49e-51 173.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1WWHF@135613|Chromatiales 135613|Chromatiales EGP Major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_287983_2 760154.Sulba_1950 3.05e-18 77.4 2BU26@1|root,32PAW@2|Bacteria,1Q3BP@1224|Proteobacteria,42X2D@68525|delta/epsilon subdivisions,2YQPU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_287983_3 1123058.KB894256_gene1316 2.96e-95 288.0 2DB9A@1|root,2Z7VI@2|Bacteria,4NJ4U@976|Bacteroidetes,1HXKW@117743|Flavobacteriia 976|Bacteroidetes S Adenine-specific methyltransferase EcoRI - - - - - - - - - - - - EcoRI_methylase k59_22974_2 1157634.KB912954_gene5818 7.83e-16 76.6 COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_453107_1 1437824.BN940_07456 2.38e-124 369.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,3T26U@506|Alcaligenaceae 28216|Betaproteobacteria C Glycolate oxidase subunit glcD - 1.1.2.4,1.1.3.15,1.1.5.12 ko:K00102,ko:K00104,ko:K03777 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00197,R00475,R00704,R11591 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_453107_2 395019.Bmul_2653 5.03e-38 138.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,1K1XC@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_419254_1 246200.SPO3036 2.59e-76 248.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4ND2Q@97050|Ruegeria 28211|Alphaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_453108_1 1499967.BAYZ01000089_gene5013 6.25e-36 136.0 COG1519@1|root,COG1519@2|Bacteria,2NP5A@2323|unclassified Bacteria 2|Bacteria M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) waaA GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527,ko:K03439 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03016 - GT30 - Glycos_transf_N k59_584257_1 95619.PM1_0200115 6.19e-59 206.0 COG0834@1|root,COG5001@1|root,COG0834@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_9,SBP_bac_3 k59_682551_1 519989.ECTPHS_01904 6.23e-81 254.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales 135613|Chromatiales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_453111_1 754476.Q7A_1669 5.99e-64 197.0 COG0346@1|root,COG0346@2|Bacteria,1RIR2@1224|Proteobacteria,1S7P4@1236|Gammaproteobacteria,462R7@72273|Thiotrichales 72273|Thiotrichales E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_453111_2 582744.Msip34_0434 1.73e-73 223.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,2KMKZ@206350|Nitrosomonadales 206350|Nitrosomonadales O OsmC-like protein - - - ko:K07397 - - - - ko00000 - - - OsmC k59_355829_1 472759.Nhal_1654 1.03e-36 144.0 COG3637@1|root,COG3637@2|Bacteria,1R42W@1224|Proteobacteria,1RYPE@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Putative outer membrane beta-barrel porin, MtrB/PioB - - - - - - - - - - - - MtrB_PioB k59_58947_1 1172190.M947_04950 5.58e-104 320.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2YRFR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Cyt-b5,POR,POR_N k59_58947_2 929558.SMGD1_2400 1.86e-73 227.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2YNSU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_160542_1 1492738.FEM21_26690 1.73e-59 199.0 COG3395@1|root,COG3395@2|Bacteria,4NJ9I@976|Bacteroidetes,1IDJ3@117743|Flavobacteriia,2NYJG@237|Flavobacterium 976|Bacteroidetes S Putative nucleotide-binding of sugar-metabolising enzyme - - 2.7.1.219,2.7.1.220 ko:K22129 - - - - ko00000,ko01000 - - - DUF1357_C,DUF1537 k59_160542_2 1121887.AUDK01000001_gene667 6.26e-122 357.0 COG1995@1|root,COG1995@2|Bacteria,4NEUR@976|Bacteroidetes,1HWZ8@117743|Flavobacteriia,2NYN3@237|Flavobacterium 976|Bacteroidetes C Pyridoxal phosphate biosynthetic protein PdxA pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_745436_1 344747.PM8797T_05330 2.87e-29 120.0 COG0477@1|root,COG2814@2|Bacteria,2IXU5@203682|Planctomycetes 203682|Planctomycetes EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_288012_1 2340.JV46_08950 3.38e-19 89.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RPMH@1236|Gammaproteobacteria,1J85K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_288012_2 754476.Q7A_413 2.08e-61 195.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1S0IN@1236|Gammaproteobacteria,463NM@72273|Thiotrichales 72273|Thiotrichales K PFAM Response regulator receiver domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_552256_1 926562.Oweho_2402 2.26e-119 350.0 2EG06@1|root,339S8@2|Bacteria,4P1XT@976|Bacteroidetes,1I7TB@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_442847_1 706587.Desti_1526 6.52e-22 96.3 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42MN3@68525|delta/epsilon subdivisions,2WMHC@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_442847_2 1169144.KB910965_gene3034 1.84e-08 57.8 COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,4HCJG@91061|Bacilli,1ZDES@1386|Bacillus 91061|Bacilli O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_835883_1 477228.YO5_01046 7.38e-70 226.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1Z3VI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Outer membrane efflux protein - - - ko:K18300 - M00641 - - ko00000,ko00002,ko01504,ko02000 1.B.17 - - OEP k59_640410_1 1121405.dsmv_2065 3.55e-87 270.0 COG4012@1|root,COG4012@2|Bacteria,1R94F@1224|Proteobacteria,42Q7K@68525|delta/epsilon subdivisions,2WK3Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Domain of unkown function DUF1786 - - - - - - - - - - - - DUF1786 k59_378415_1 765913.ThidrDRAFT_3527 2.74e-68 219.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1WY1X@135613|Chromatiales 135613|Chromatiales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_607866_1 1117647.M5M_19315 1.17e-15 77.4 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_607866_2 631454.N177_3895 6.42e-90 282.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,1JPY4@119043|Rhodobiaceae 28211|Alphaproteobacteria C Proton-conducting membrane transporter nuoL2 - 1.6.5.3 ko:K00341,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_574887_1 1122201.AUAZ01000006_gene3874 9.58e-122 360.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,4644I@72275|Alteromonadaceae 1236|Gammaproteobacteria E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_574889_1 709032.Sulku_1458 1.22e-50 161.0 COG1146@1|root,COG1146@2|Bacteria,1NJJD@1224|Proteobacteria,42TVE@68525|delta/epsilon subdivisions,2YPUN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 2-oxoglutarate acceptor oxidoreductase oorD - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_6,Fer4_7 k59_574889_2 1537917.JU82_05485 4.49e-118 347.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2YMD2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase oorA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_410784_1 1121405.dsmv_2653 3.56e-108 321.0 COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,42RGI@68525|delta/epsilon subdivisions,2WNGP@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_28,HTH_33 k59_640419_1 1195236.CTER_3530 4.9e-83 265.0 COG1166@1|root,COG1166@2|Bacteria,1UZ22@1239|Firmicutes,24EU9@186801|Clostridia 186801|Clostridia H Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_183317_2 326298.Suden_1259 4.95e-97 299.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1R5RS@1224|Proteobacteria,42M3K@68525|delta/epsilon subdivisions,2YN6E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM biotin lipoyl attachment domain-containing protein pycB - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_966788_1 118797.XP_007457196.1 6.38e-70 219.0 COG0096@1|root,COG0097@1|root,KOG1754@2759|Eukaryota,KOG3254@2759|Eukaryota,39WCS@33154|Opisthokonta 33154|Opisthokonta J rRNA binding MRPL6 GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_966788_2 472759.Nhal_2399 3.6e-09 54.7 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,1WXYT@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_868854_3 1123278.KB893575_gene1424 2.05e-29 117.0 COG0356@1|root,COG0356@2|Bacteria,4NGH0@976|Bacteroidetes,47P0D@768503|Cytophagia 976|Bacteroidetes C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_836565_1 1121479.AUBS01000031_gene104 4.53e-48 170.0 COG5295@1|root,COG5295@2|Bacteria,1QVE2@1224|Proteobacteria,2TWD5@28211|Alphaproteobacteria 28211|Alphaproteobacteria UW Protein of unknown function (DUF2793) - - - - - - - - - - - - DUF2793,Peptidase_G2 k59_476630_1 1123501.KB902279_gene615 4.35e-139 407.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_151401_1 525898.Sdel_2170 2.1e-28 109.0 COG4314@1|root,COG4314@2|Bacteria,1N3G0@1224|Proteobacteria,42SNT@68525|delta/epsilon subdivisions,2YPPG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - - k59_443598_1 396588.Tgr7_2304 1.07e-63 207.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales 135613|Chromatiales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_543200_1 1172190.M947_11340 2.09e-68 219.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,42NNW@68525|delta/epsilon subdivisions,2YN9Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM ABC transporter - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_543200_2 1172190.M947_11330 2.27e-81 249.0 COG1682@1|root,COG1682@2|Bacteria,1MYJW@1224|Proteobacteria,43AND@68525|delta/epsilon subdivisions,2YNXV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM Transport permease protein - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane k59_347745_1 946483.Cenrod_0547 0.000132 49.7 29DRS@1|root,300PM@2|Bacteria,1RF8B@1224|Proteobacteria,2VR3X@28216|Betaproteobacteria,4AE2G@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_347745_2 929558.SMGD1_0347 2.46e-77 234.0 COG1704@1|root,COG1704@2|Bacteria,1N0DU@1224|Proteobacteria,43B6Y@68525|delta/epsilon subdivisions,2YPB4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_216589_1 298386.PBPRA1988 2.46e-83 274.0 COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XVUA@135623|Vibrionales 135623|Vibrionales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_641179_1 944547.ABLL_0024 2.73e-54 184.0 COG0614@1|root,COG0614@2|Bacteria,1MUSZ@1224|Proteobacteria,42M6P@68525|delta/epsilon subdivisions,2YMAW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_347757_1 472759.Nhal_0204 3.47e-43 142.0 COG3549@1|root,COG3549@2|Bacteria,1MZ4I@1224|Proteobacteria,1S9CP@1236|Gammaproteobacteria,1X16E@135613|Chromatiales 135613|Chromatiales S Plasmid maintenance system killer - - - ko:K07334 - - - - ko00000,ko02048 - - - HigB-like_toxin k59_347757_2 765914.ThisiDRAFT_1569 1.19e-49 159.0 COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1S83W@1236|Gammaproteobacteria 1236|Gammaproteobacteria K addiction module antidote protein, HigA family ybaQ GO:0008150,GO:0009636,GO:0042221,GO:0050896 - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_575570_1 1453503.AU05_05980 1.35e-45 152.0 COG4665@1|root,COG4665@2|Bacteria,1RDYM@1224|Proteobacteria,1S58A@1236|Gammaproteobacteria,1YGBG@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_575570_2 911045.PSE_p0344 7.79e-13 67.8 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component dctM1 - - - - - - - - - - - DctM k59_279349_1 1123073.KB899243_gene683 3.71e-14 77.4 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales 135614|Xanthomonadales T Adenylate cyclase - - - - - - - - - - - - TPR_8 k59_1000563_1 768671.ThimaDRAFT_0092 1.29e-31 117.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1WXBZ@135613|Chromatiales 135613|Chromatiales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_50334_1 215803.DB30_4665 5.1e-29 115.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales 28221|Deltaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_608519_1 760142.Hipma_0654 4.18e-19 91.3 COG5377@1|root,COG5377@2|Bacteria,1R7HX@1224|Proteobacteria,42PAT@68525|delta/epsilon subdivisions,2WPCT@28221|Deltaproteobacteria 28221|Deltaproteobacteria L YqaJ viral recombinase family - - - - - - - - - - - - - k59_248210_1 740709.A10D4_03500 2.93e-113 340.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,2QFAU@267893|Idiomarinaceae 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_706102_1 1049564.TevJSym_by00060 7.13e-47 152.0 2E7PJ@1|root,33255@2|Bacteria,1NANJ@1224|Proteobacteria,1SDCV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_706102_2 998674.ATTE01000001_gene1029 8.7e-11 62.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,460EA@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_868888_1 1333998.M2A_0409 3.66e-42 154.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_706103_1 326297.Sama_1174 6.5e-69 223.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,2QAY9@267890|Shewanellaceae 1236|Gammaproteobacteria E PFAM glutamine synthetase catalytic region - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1000575_1 177439.DP0070 4.39e-09 59.3 28PU4@1|root,2ZCF6@2|Bacteria,1N6FV@1224|Proteobacteria,43B3C@68525|delta/epsilon subdivisions,2X6H3@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_347778_2 929558.SMGD1_1848 1.45e-148 424.0 COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2YM84@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterised conserved protein (DUF2156) - - - ko:K01163 - - - - ko00000 - - - DUF2156 k59_279369_1 519989.ECTPHS_08558 3.37e-85 279.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_902009_1 749222.Nitsa_1979 3.25e-38 131.0 2ADBR@1|root,31316@2|Bacteria,1RD6U@1224|Proteobacteria,430GW@68525|delta/epsilon subdivisions,2YS4Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF2853) - - - - - - - - - - - - DUF2853 k59_771241_1 1233950.IW22_16420 8.92e-52 184.0 COG3250@1|root,COG3250@2|Bacteria,4NGZH@976|Bacteroidetes,1HY22@117743|Flavobacteriia,3ZPUA@59732|Chryseobacterium 976|Bacteroidetes G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_117841_1 573413.Spirs_1825 6.72e-29 113.0 COG2197@1|root,COG2197@2|Bacteria,2J6J1@203691|Spirochaetes 203691|Spirochaetes K regulator - - - - - - - - - - - - GerE,Response_reg k59_674309_1 314285.KT71_16836 3.17e-37 142.0 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,1T241@1236|Gammaproteobacteria,1J9KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_379197_1 1049564.TevJSym_bc00320 3.77e-25 97.1 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564 - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_379197_2 1249627.D779_1109 1.69e-35 122.0 COG0298@1|root,COG0298@2|Bacteria,1QKV6@1224|Proteobacteria,1SE6V@1236|Gammaproteobacteria,1WZDC@135613|Chromatiales 135613|Chromatiales O PFAM hydrogenase expression formation protein (HUPF HYPC) - - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_836612_1 316067.Geob_0394 4.41e-61 210.0 COG2766@1|root,COG2766@2|Bacteria,1NG7R@1224|Proteobacteria,42P8B@68525|delta/epsilon subdivisions,2WJIU@28221|Deltaproteobacteria,43S2Z@69541|Desulfuromonadales 28221|Deltaproteobacteria T PrkA serine protein kinase C-terminal domain - - - - - - - - - - - - AAA_PrkA,PrkA k59_476660_1 1249627.D779_1826 7.07e-118 366.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_476660_2 1249627.D779_1825 3.14e-129 384.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1SYV1@1236|Gammaproteobacteria,1X2IS@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_511255_1 1168034.FH5T_07145 1.42e-48 162.0 COG2825@1|root,COG2825@2|Bacteria 2|Bacteria M unfolded protein binding ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_641217_1 1537917.JU82_07120 1.1e-13 70.5 COG2897@1|root,COG2897@2|Bacteria,1PI99@1224|Proteobacteria,42PX2@68525|delta/epsilon subdivisions,2YNFU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_216621_1 572544.Ilyop_1753 2.83e-130 379.0 COG1104@1|root,COG1104@2|Bacteria,378KB@32066|Fusobacteria 32066|Fusobacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine nifS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_411504_1 1123401.JHYQ01000005_gene263 1.02e-80 247.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1SQ2U@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Thiosulfate-oxidizing multienzyme system protein SoxA - - - - - - - - - - - - - k59_771257_1 1173024.KI912149_gene5528 3.86e-07 56.2 COG0642@1|root,COG0784@1|root,COG2199@1|root,COG2202@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria,1JKNQ@1189|Stigonemataceae 1117|Cyanobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_84782_1 933262.AXAM01000023_gene663 5.74e-64 216.0 COG0079@1|root,COG0283@1|root,COG0079@2|Bacteria,COG0283@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,2MIX3@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_935149_1 1174684.EBMC1_11535 1.21e-11 68.2 COG4935@1|root,COG4935@2|Bacteria,1RK8D@1224|Proteobacteria,2UKHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,P_proprotein k59_641232_1 1254432.SCE1572_15650 8.1e-34 134.0 COG0515@1|root,COG1366@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG1366@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,1RGKE@1224|Proteobacteria 1224|Proteobacteria T GAF domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,GAF,GAF_2,HATPase_c,HD,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Pkinase,STAS,SpoIIE k59_800551_1 1121935.AQXX01000107_gene619 1.06e-11 67.8 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C k59_800551_2 944547.ABLL_0833 1.05e-46 156.0 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,42S37@68525|delta/epsilon subdivisions,2YTR8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_706119_2 1537917.JU82_00625 6.56e-168 476.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2YMXF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_706119_3 709032.Sulku_1026 7.37e-49 161.0 2AHYJ@1|root,318BT@2|Bacteria,1Q04R@1224|Proteobacteria,42RKI@68525|delta/epsilon subdivisions,2YPAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_935167_1 983548.Krodi_1958 1.14e-20 90.1 COG1051@1|root,COG1051@2|Bacteria,4NS9I@976|Bacteroidetes,1HZFF@117743|Flavobacteriia,37EXI@326319|Dokdonia 976|Bacteroidetes F NUDIX domain - - - - - - - - - - - - NUDIX k59_935167_2 1168034.FH5T_09695 1.28e-128 382.0 COG0526@1|root,COG0526@2|Bacteria,4NNSW@976|Bacteroidetes,2FXHS@200643|Bacteroidia 976|Bacteroidetes CO AhpC/TSA family - - - - - - - - - - - - AhpC-TSA,Thioredoxin_8 k59_476693_2 1168034.FH5T_10125 7.31e-46 152.0 COG0494@1|root,COG0494@2|Bacteria,4NSND@976|Bacteroidetes,2G0XF@200643|Bacteroidia 976|Bacteroidetes L NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_476693_3 1168034.FH5T_10120 4.29e-70 216.0 2EVWW@1|root,33PAJ@2|Bacteria,4NZKD@976|Bacteroidetes,2FZQQ@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_476693_4 1168034.FH5T_10115 2.23e-95 286.0 COG1052@1|root,COG1052@2|Bacteria,4NIHV@976|Bacteroidetes,2FPG0@200643|Bacteroidia 976|Bacteroidetes C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family hprA - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_800566_1 558884.JRGM01000038_gene1970 6.55e-82 251.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1Y43S@135624|Aeromonadales 135624|Aeromonadales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_443682_1 999141.GME_07266 2.17e-98 297.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1XHD6@135619|Oceanospirillales 135619|Oceanospirillales K in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_216645_1 1127134.NOCYR_2413 4.45e-06 54.3 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,4FW1H@85025|Nocardiaceae 201174|Actinobacteria P Flavin-binding monooxygenase-like - - 1.14.13.22 ko:K03379 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_3 k59_737426_2 1168034.FH5T_00630 2.91e-55 186.0 COG1069@1|root,COG1069@2|Bacteria,4NEFQ@976|Bacteroidetes,2FNNI@200643|Bacteroidia 976|Bacteroidetes G Belongs to the ribulokinase family araB - 2.7.1.16 ko:K00853 ko00040,ko01100,map00040,map01100 - R01526,R02439 RC00002,RC00538 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_312852_1 1168289.AJKI01000004_gene2941 1.56e-42 148.0 COG3385@1|root,COG3385@2|Bacteria,4NX1P@976|Bacteroidetes,2FURU@200643|Bacteroidia 976|Bacteroidetes L COG COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - - k59_874412_1 563040.Saut_0373 6.77e-92 291.0 COG3303@1|root,COG3303@2|Bacteria,1QXPE@1224|Proteobacteria,42NA5@68525|delta/epsilon subdivisions,2YN2W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P cytochrome c - - - - - - - - - - - - Cytochrome_C554 k59_284770_1 523791.Kkor_0189 6.72e-77 241.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1XH97@135619|Oceanospirillales 135619|Oceanospirillales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_806067_1 450851.PHZ_c3265 2.45e-38 144.0 COG2956@1|root,COG3555@1|root,COG2956@2|Bacteria,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,2U5YV@28211|Alphaproteobacteria,2KIFZ@204458|Caulobacterales 204458|Caulobacterales GO Aspartyl/Asparaginyl beta-hydroxylase - - - - - - - - - - - - Asp_Arg_Hydrox k59_680038_1 1172190.M947_03010 3.31e-200 586.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42MWW@68525|delta/epsilon subdivisions,2YMMH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_549156_1 658187.LDG_7585 1.35e-59 194.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1JDF5@118969|Legionellales 118969|Legionellales L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_55742_1 1168034.FH5T_18540 1.64e-79 246.0 COG0449@1|root,COG0449@2|Bacteria,4NK32@976|Bacteroidetes 976|Bacteroidetes M glutamine-fructose-6-phosphate transaminase (isomerizing) activity - - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - - k59_874423_1 710111.FraQA3DRAFT_1161 3.25e-189 533.0 COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria,4ETSU@85013|Frankiales 201174|Actinobacteria S Epoxide hydrolase - - 3.3.2.9 ko:K01253 ko00980,ko04976,ko05204,map00980,map04976,map05204 - R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 - - - EHN k59_221943_1 1042209.HK44_015600 1.95e-06 49.7 COG3152@1|root,COG3152@2|Bacteria,1NBFY@1224|Proteobacteria,1SHJN@1236|Gammaproteobacteria,1YNKZ@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Protein of unknown function (DUF805) - - - - - - - - - - - - DUF805 k59_318107_1 1121439.dsat_2101 1.51e-81 269.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2M85Y@213115|Desulfovibrionales 28221|Deltaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin poR - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_972825_1 1144275.COCOR_01492 4.02e-50 182.0 COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,1R5MU@1224|Proteobacteria,42UIQ@68525|delta/epsilon subdivisions,2WQAN@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - - k59_614205_1 1165841.SULAR_03767 2.82e-109 326.0 COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2YNIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1085 Galactose-1-phosphate uridylyltransferase galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf k59_157400_1 1168034.FH5T_20355 9.55e-129 389.0 COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes 976|Bacteroidetes E Aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_614207_2 1300345.LF41_1864 4.35e-19 87.4 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_449691_1 572480.Arnit_2656 4.85e-88 272.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2YNE6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_385095_1 1238182.C882_1124 5.05e-174 500.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPZI@204441|Rhodospirillales 204441|Rhodospirillales C belongs to the aldehyde dehydrogenase family puuC - 1.2.1.54,1.2.1.99 ko:K09472,ko:K12254 ko00330,ko01100,map00330,map01100 M00136 R02549,R03177,R07417,R07418 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_385095_2 1207063.P24_07479 1.9e-120 351.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,2JPM8@204441|Rhodospirillales 204441|Rhodospirillales S Carbon-nitrogen hydrolase aguB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_614208_1 983920.Y88_0779 9.39e-11 66.2 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K8IX@204457|Sphingomonadales 204457|Sphingomonadales EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_614208_2 1192868.CAIU01000003_gene410 3.21e-07 52.4 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,43HM4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EQ N-methylhydantoinase A acetone carboxylase, beta subunit - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_841990_1 387093.SUN_2046 1.55e-10 67.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2YMWR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_157410_1 754477.Q7C_2253 1.61e-23 103.0 2DSG4@1|root,32UT2@2|Bacteria,1N47W@1224|Proteobacteria,1SEA4@1236|Gammaproteobacteria,462QY@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_776852_1 768671.ThimaDRAFT_2821 3.3e-29 116.0 COG0845@1|root,COG0845@2|Bacteria,1PVWV@1224|Proteobacteria,1S2QY@1236|Gammaproteobacteria,1X2DZ@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_776852_2 768671.ThimaDRAFT_1328 1.81e-20 91.3 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1X0QV@135613|Chromatiales 135613|Chromatiales P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - CitMHS,TrkA_C k59_614212_1 448385.sce6815 9.43e-54 184.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,2YV6M@29|Myxococcales 28221|Deltaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_742838_2 1168034.FH5T_05905 7.51e-95 281.0 COG1595@1|root,COG1595@2|Bacteria,4NQTP@976|Bacteroidetes,2FU81@200643|Bacteroidia 976|Bacteroidetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_972841_1 1116375.VEJY3_12370 1.42e-12 75.5 COG3391@1|root,COG3391@2|Bacteria,1NJ9D@1224|Proteobacteria,1SHPW@1236|Gammaproteobacteria,1XXRP@135623|Vibrionales 135623|Vibrionales S amine dehydrogenase activity - - - - - - - - - - - - - k59_1037943_1 1190603.AJYD01000103_gene429 1.43e-37 132.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1XTHN@135623|Vibrionales 135623|Vibrionales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_221965_1 1333856.L686_18730 2.44e-76 244.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1Z1JG@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E glutamine synthetase puuA GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575 6.3.1.11,6.3.1.2 ko:K01915,ko:K09470 ko00220,ko00250,ko00330,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 M00136 R00253,R07414 RC00010,RC00090,RC00096,RC02798 ko00000,ko00001,ko00002,ko01000,ko04147 - - iB21_1397.B21_01285,iECBD_1354.ECBD_2320,iECB_1328.ECB_01274,iECD_1391.ECD_01274,iSF_1195.SF1302 Gln-synt_C k59_157423_1 394221.Mmar10_0331 6.74e-70 233.0 COG4783@1|root,COG5616@1|root,COG4783@2|Bacteria,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae 28211|Alphaproteobacteria K cAMP biosynthetic process - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C k59_1037949_1 439235.Dalk_5107 2.45e-57 199.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2MIKW@213118|Desulfobacterales 28221|Deltaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_581272_1 667014.Thein_0728 6.55e-33 117.0 2DNS7@1|root,32YWC@2|Bacteria 2|Bacteria S S23 ribosomal protein - - - - - - - - - - - - 23S_rRNA_IVP k59_581272_2 1537917.JU82_03750 1.05e-120 352.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,42M6U@68525|delta/epsilon subdivisions,2YN4H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - 1.21.98.1 ko:K11784 ko00130,ko01110,map00130,map01110 - R08588 RC02329 ko00000,ko00001,ko01000 - - - Radical_SAM k59_711672_1 1026882.MAMP_02104 4.27e-38 143.0 COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,1RPFY@1236|Gammaproteobacteria,460R4@72273|Thiotrichales 72273|Thiotrichales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07637 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HATPase_c k59_874446_1 696281.Desru_3351 5.77e-38 142.0 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,260TC@186807|Peptococcaceae 186801|Clostridia M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1037959_1 1123487.KB892865_gene1453 1.48e-56 191.0 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2VJ4P@28216|Betaproteobacteria,2KUDC@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_55785_1 485918.Cpin_1599 2.52e-46 173.0 COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,1IPNA@117747|Sphingobacteriia 976|Bacteroidetes M mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_481829_1 1249480.B649_09505 2.19e-42 148.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2YMQU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the HypD family hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_481829_2 709032.Sulku_2035 3.09e-35 122.0 COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,42X24@68525|delta/epsilon subdivisions,2YPV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O hydrogenase assembly chaperone HypC hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_416712_1 357808.RoseRS_1075 1.09e-14 80.5 COG0577@1|root,COG0577@2|Bacteria,2G68F@200795|Chloroflexi,376ZY@32061|Chloroflexia 32061|Chloroflexia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_742853_1 1121403.AUCV01000005_gene345 5.93e-118 360.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MIU8@213118|Desulfobacterales 28221|Deltaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_353215_2 83406.HDN1F_03640 5.95e-09 53.5 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,1S3QX@1236|Gammaproteobacteria,1J66Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_742855_1 913325.N799_06230 5e-79 262.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1X3VS@135614|Xanthomonadales 135614|Xanthomonadales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_449729_1 713586.KB900536_gene3033 7.07e-104 308.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_19954_1 322710.Avin_41510 2.44e-71 224.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_1304 GHMP_kinases_C,GHMP_kinases_N k59_874464_1 1134912.AJTV01000013_gene609 8.29e-82 260.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_385147_1 1121405.dsmv_3069 2.16e-26 103.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria,2MICA@213118|Desulfobacterales 28221|Deltaproteobacteria E ABC transporter - - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_385147_2 1121405.dsmv_3070 2.9e-45 155.0 COG0765@1|root,COG0765@2|Bacteria,1MX3E@1224|Proteobacteria,42N9B@68525|delta/epsilon subdivisions,2WIYW@28221|Deltaproteobacteria,2MJ3R@213118|Desulfobacterales 28221|Deltaproteobacteria E Binding-protein-dependent transport system inner membrane component - - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1,SBP_bac_3 k59_55806_1 338963.Pcar_0882 1.83e-105 327.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,43TQK@69541|Desulfuromonadales 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB-2 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_157469_1 991905.SL003B_0857 3.13e-06 49.7 COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,4BQC9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Inositol monophosphatase family hisN - 3.1.3.15,3.1.3.25,3.1.3.93 ko:K01092,ko:K18649 ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070 M00026,M00114,M00131 R01185,R01186,R01187,R03013,R07674 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_189667_1 1165841.SULAR_02033 3.95e-56 187.0 2A54K@1|root,30TT8@2|Bacteria,1Q98H@1224|Proteobacteria,4348V@68525|delta/epsilon subdivisions,2YRCN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_972876_2 697281.Mahau_1888 1.8e-15 72.4 COG2111@1|root,COG2111@2|Bacteria,1VPIK@1239|Firmicutes,24VEZ@186801|Clostridia 186801|Clostridia P Na H antiporter - - - - - - - - - - - - - k59_972876_3 1511.CLOST_1185 5.37e-08 52.8 COG2111@1|root,COG2111@2|Bacteria 2|Bacteria P Na H antiporter mnhB - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MnhB k59_90846_1 749222.Nitsa_1752 7.98e-111 335.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2YN87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Abc transporter nikZ - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_284859_1 177437.HRM2_23760 1.06e-41 150.0 COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria,2MKDX@213118|Desulfobacterales 28221|Deltaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_907510_1 406124.ACPC01000009_gene1241 8.03e-12 70.5 COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,4HAYQ@91061|Bacilli,1ZCK2@1386|Bacillus 91061|Bacilli S protein conserved in bacteria yitS - - - - - - - - - - - DegV k59_157476_1 765914.ThisiDRAFT_0303 2.47e-70 225.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1WWWV@135613|Chromatiales 135613|Chromatiales M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_581323_1 1537917.JU82_02560 4.56e-193 540.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,42M3V@68525|delta/epsilon subdivisions,2YMJP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0625 GcpE k59_449754_1 1121090.KB894687_gene915 1.01e-08 65.5 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,1ZAY7@1386|Bacillus 91061|Bacilli V ABC transporter ygaD GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_517438_1 455632.SGR_1811 1.51e-49 178.0 COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4180C@629295|Streptomyces griseus group 201174|Actinobacteria J Translation-initiation factor 2 infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_517438_2 871968.DESME_15855 1.79e-09 60.8 COG1196@1|root,COG1196@2|Bacteria,1VAV4@1239|Firmicutes,24NPU@186801|Clostridia,262K8@186807|Peptococcaceae 186801|Clostridia D Protein of unknown function (DUF4446) - - - - - - - - - - - - DUF4446 k59_1006699_1 634994.GCWU000323_02550 1.53e-113 339.0 COG0439@1|root,COG0439@2|Bacteria,379P7@32066|Fusobacteria 32066|Fusobacteria I acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_417327_1 401526.TcarDRAFT_2584 2.08e-18 90.1 COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,4H6A4@909932|Negativicutes 909932|Negativicutes L Mu transposase, C-terminal - - - - - - - - - - - - Mu-transpos_C,rve k59_518207_1 526218.Sterm_0202 7.6e-61 197.0 COG0224@1|root,COG0224@2|Bacteria,378FI@32066|Fusobacteria 32066|Fusobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_450615_1 50452.A0A087HE51 3.37e-118 373.0 2CMQD@1|root,2QRDV@2759|Eukaryota,37QIN@33090|Viridiplantae,3GEA1@35493|Streptophyta 35493|Streptophyta S function. Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis ycf2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0009507,GO:0009526,GO:0009536,GO:0009941,GO:0015031,GO:0015833,GO:0016020,GO:0017038,GO:0031967,GO:0031975,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045036,GO:0045037,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072594,GO:0072596,GO:0072598 - - - - - - - - - - AAA,DUF825 k59_124391_1 990285.RGCCGE502_23085 2.17e-29 115.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,4B788@82115|Rhizobiaceae 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_124391_2 563040.Saut_0777 5.44e-60 187.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2YPWF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_124391_3 563040.Saut_0778 7.11e-17 76.6 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2YNC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U MotA TolQ ExbB proton channel family tolQ - - - - - - - - - - - MotA_ExbB k59_353856_1 522772.Dacet_2742 2.83e-52 186.0 COG0841@1|root,COG0841@2|Bacteria,2GESU@200930|Deferribacteres 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_806757_1 572480.Arnit_1952 8.31e-22 93.2 COG1934@1|root,COG1934@2|Bacteria,1NJS7@1224|Proteobacteria,42SEJ@68525|delta/epsilon subdivisions,2YPFN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Lipopolysaccharide transport periplasmic protein lpta lptA - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_1038909_1 587753.EY04_03620 6.2e-13 74.7 COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Thymidine phosphorylase - - - - - - - - - - - - DUF1631 k59_417337_1 700598.Niako_2686 6.52e-51 176.0 COG2610@1|root,COG2610@2|Bacteria,4NJ5B@976|Bacteroidetes,1IWIE@117747|Sphingobacteriia 976|Bacteroidetes EG COGs COG2610 H gluconate symporter and related permease - - - ko:K03299 - - - - ko00000,ko02000 2.A.8 - - GntP_permease k59_318760_1 1201290.M902_1459 3.34e-34 130.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2MSXI@213481|Bdellovibrionales,2WIX8@28221|Deltaproteobacteria 213481|Bdellovibrionales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh,PDZ_2 k59_743520_1 83406.HDN1F_09060 1.16e-52 187.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria,1J7RY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_20897_1 1242864.D187_006660 1.86e-102 307.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales 28221|Deltaproteobacteria H Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_973551_1 472759.Nhal_3536 1.38e-61 210.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_941668_2 710111.FraQA3DRAFT_3115 1.94e-11 67.8 COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4ERRX@85013|Frankiales 201174|Actinobacteria D Belongs to the SEDS family mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_680675_1 469618.FVAG_01904 1.24e-61 211.0 COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3784G@32066|Fusobacteria 32066|Fusobacteria I acyl carrier protein - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,Acyltransferase,PP-binding k59_222726_1 1121428.DESHY_70062___1 4.27e-203 616.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae 186801|Clostridia L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_482348_1 631362.Thi970DRAFT_02291 2.28e-159 471.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales 135613|Chromatiales M HAD-superfamily hydrolase, subfamily IIB - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_450641_2 572477.Alvin_2486 8.36e-100 308.0 COG0750@1|root,COG3016@1|root,COG0750@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales 135613|Chromatiales O smart pdz dhr glgf - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_124427_1 335543.Sfum_2068 1.16e-17 79.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,42SJW@68525|delta/epsilon subdivisions,2WPF7@28221|Deltaproteobacteria,2MQHX@213462|Syntrophobacterales 28221|Deltaproteobacteria J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE k59_124427_2 880072.Desac_2098 6.32e-43 154.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2MQBH@213462|Syntrophobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_947408_2 749222.Nitsa_1055 7e-43 141.0 COG1343@1|root,COG1343@2|Bacteria,1Q9U5@1224|Proteobacteria,42W5A@68525|delta/epsilon subdivisions,2YPT5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 k59_947408_3 749222.Nitsa_1054 4.84e-92 271.0 COG1468@1|root,COG1468@2|Bacteria,1RGP6@1224|Proteobacteria,42PDJ@68525|delta/epsilon subdivisions,2YPEU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L CRISPR-associated protein Cas4 cas4 - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas4 k59_97624_27 1122951.ATUE01000007_gene563 1.34e-93 279.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,3NT4G@468|Moraxellaceae 1236|Gammaproteobacteria P Reversible hydration of carbon dioxide can GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_0115,iSbBS512_1146.SbBS512_E0119 Pro_CA k59_97624_28 396588.Tgr7_0578 1.56e-246 692.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1WW0Q@135613|Chromatiales 135613|Chromatiales EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_63148_1 519989.ECTPHS_05435 1.11e-79 249.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_848798_1 416591.Tlet_0573 8.03e-77 249.0 COG1966@1|root,COG1966@2|Bacteria,2GCFJ@200918|Thermotogae 200918|Thermotogae T PFAM Carbon starvation protein CstA - - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_784102_1 367737.Abu_1733 6.85e-20 88.2 COG0526@1|root,COG0526@2|Bacteria,1Q6CC@1224|Proteobacteria,432UY@68525|delta/epsilon subdivisions,2YSUU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_784102_2 887062.HGR_13919 5.12e-17 76.6 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,4AEW8@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Cytochrome c, class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_749914_1 863365.XHC_1600 4.11e-90 284.0 COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X3WH@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1012908_1 198628.Dda3937_02500 1.38e-58 191.0 COG1876@1|root,COG1876@2|Bacteria,1N2IC@1224|Proteobacteria,1S0DU@1236|Gammaproteobacteria,2JCRJ@204037|Dickeya 1236|Gammaproteobacteria M PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin vanY - - - - - - - - - - - VanY k59_813780_1 572544.Ilyop_0816 2.06e-159 457.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - 2.4.1.60 ko:K07011,ko:K13005 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_2 k59_261110_1 1158762.KB898037_gene2332 1.98e-44 163.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_423804_1 1168034.FH5T_04265 1.64e-72 224.0 COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,2FMI3@200643|Bacteroidia 976|Bacteroidetes H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_423804_2 1168034.FH5T_04260 1.23e-115 338.0 2C52N@1|root,2Z7U1@2|Bacteria,4NEZW@976|Bacteroidetes,2FNRZ@200643|Bacteroidia 976|Bacteroidetes S PorT protein porT - - - - - - - - - - - OMP_b-brl_2 k59_784117_1 1042375.AFPL01000054_gene2133 2.78e-61 219.0 COG0591@1|root,COG0642@1|root,COG4191@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,464E5@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0591 Na proline symporter - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg,SSF k59_27211_1 42565.FP66_07185 1.94e-05 46.6 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1XH5S@135619|Oceanospirillales 135619|Oceanospirillales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_914540_1 1291050.JAGE01000002_gene3678 4.12e-32 129.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia 186801|Clostridia Q Beta-ketoacyl synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_749948_1 765912.Thimo_0962 1.81e-67 221.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWSK@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_914542_1 426114.THI_1757 5.39e-58 206.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1KJJ2@119065|unclassified Burkholderiales 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_813802_2 1121286.AUMT01000013_gene2625 3.56e-10 63.9 COG4974@1|root,COG4974@2|Bacteria,4NGQW@976|Bacteroidetes,1HWMN@117743|Flavobacteriia,3ZPHS@59732|Chryseobacterium 976|Bacteroidetes L Belongs to the 'phage' integrase family xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_881423_1 637905.SVI_3141 8.77e-87 271.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,2Q9VE@267890|Shewanellaceae 1236|Gammaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_749953_1 637905.SVI_1752 1.94e-07 52.8 COG4221@1|root,COG4221@2|Bacteria,1PWXN@1224|Proteobacteria,1S226@1236|Gammaproteobacteria,2QBUK@267890|Shewanellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4336) - - - - - - - - - - - - DUF4336 k59_749953_2 697282.Mettu_2755 1.45e-47 158.0 COG1309@1|root,COG1309@2|Bacteria,1N1X6@1224|Proteobacteria,1S9GI@1236|Gammaproteobacteria,1XDKS@135618|Methylococcales 135618|Methylococcales K PFAM Transcriptional regulator, TetR-like, DNA-binding, bacterial archaeal - - - - - - - - - - - - TetR_N k59_1045175_1 1304885.AUEY01000002_gene439 1.1e-35 139.0 COG2706@1|root,COG2931@1|root,COG2982@1|root,COG3210@1|root,COG4625@1|root,COG2706@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,4345K@68525|delta/epsilon subdivisions,2X15Q@28221|Deltaproteobacteria,2MMPA@213118|Desulfobacterales 28221|Deltaproteobacteria MQU COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_914551_1 470145.BACCOP_02209 3.28e-71 217.0 COG0756@1|root,COG0756@2|Bacteria,4NNI4@976|Bacteroidetes,2FR7A@200643|Bacteroidia,4AP3D@815|Bacteroidaceae 976|Bacteroidetes F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_914551_2 1168034.FH5T_07885 8.22e-14 71.6 COG0457@1|root,COG0457@2|Bacteria,4NDVW@976|Bacteroidetes,2FMY8@200643|Bacteroidia 976|Bacteroidetes NU Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_813815_1 305700.B447_11277 4.4e-23 97.8 COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,2VRCD@28216|Betaproteobacteria,2KWCR@206389|Rhodocyclales 206389|Rhodocyclales S Uncharacterised protein family (UPF0227) - - - ko:K07000 - - - - ko00000 - - - UPF0227 k59_749969_1 572544.Ilyop_1350 4.15e-35 134.0 COG1199@1|root,COG1199@2|Bacteria,378GX@32066|Fusobacteria 32066|Fusobacteria L K03722 ATP-dependent DNA helicase DinG - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2 k59_749969_2 572544.Ilyop_1351 1.34e-37 129.0 COG0268@1|root,COG0268@2|Bacteria,37AP5@32066|Fusobacteria 32066|Fusobacteria J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_63204_1 1537917.JU82_04605 1.38e-98 292.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2YMZQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1045181_1 156889.Mmc1_2196 1.34e-12 73.6 COG2931@1|root,COG3210@1|root,COG3827@1|root,COG4447@1|root,COG4625@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3827@2|Bacteria,COG4447@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Calx-beta,DUF4347,He_PIG,HemolysinCabind,VWA_2 k59_488665_1 1408439.JHXW01000001_gene1898 5.09e-14 79.3 COG3063@1|root,COG4105@1|root,COG3063@2|Bacteria,COG4105@2|Bacteria,3799H@32066|Fusobacteria 32066|Fusobacteria NU Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 k59_488665_2 1391646.AVSU01000054_gene1166 4.33e-43 150.0 COG1852@1|root,COG1852@2|Bacteria,1V1B5@1239|Firmicutes,24G2F@186801|Clostridia 186801|Clostridia S Protein of unknown function DUF116 - - - ko:K09729 - - - - ko00000 - - - DUF116 k59_488665_3 443254.Marpi_0674 1.06e-225 642.0 COG0296@1|root,COG0296@2|Bacteria,2GDYI@200918|Thermotogae 200918|Thermotogae G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_749979_1 113395.AXAI01000010_gene2316 2.6e-65 211.0 COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRU9@28211|Alphaproteobacteria,3JVRE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Amidohydrolase - - - ko:K07046 ko00051,ko01120,map00051,map01120 - R10689 RC00537 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_325262_1 1123279.ATUS01000001_gene637 5.98e-08 53.9 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,1J5QD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation ydiA GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0098772 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_813826_1 1565314.OA34_09555 1.52e-17 84.7 COG2890@1|root,COG2890@2|Bacteria 2|Bacteria J protein-(glutamine-N5) methyltransferase activity cmoA - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_261167_1 335543.Sfum_3195 8.91e-56 192.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_423839_2 929558.SMGD1_0616 3.02e-54 175.0 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,42PHC@68525|delta/epsilon subdivisions,2YNF2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H involved in molybdopterin and thiamine biosynthesis family 1 - - - - - - - - - - - - ThiF k59_881447_1 471881.PROPEN_00761 3.64e-59 186.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,3Z13Q@583|Proteus 1236|Gammaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_914572_1 105559.Nwat_2897 3.09e-124 368.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_63235_2 1118055.CAGU01000013_gene881 5.59e-26 108.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,22G59@1570339|Peptoniphilaceae 186801|Clostridia C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_980337_1 1150398.JIBJ01000004_gene2753 3.41e-97 289.0 COG0656@1|root,COG0656@2|Bacteria,2GJQ7@201174|Actinobacteria,1WAGZ@1268|Micrococcaceae 201174|Actinobacteria S Aldo/keto reductase family - - 1.1.1.346 ko:K06221 - - R08878 RC00089 ko00000,ko01000 - - - Aldo_ket_red k59_719075_1 1415780.JPOG01000001_gene495 6.88e-17 77.8 COG5430@1|root,COG5430@2|Bacteria,1RM0N@1224|Proteobacteria,1SCED@1236|Gammaproteobacteria,1X854@135614|Xanthomonadales 135614|Xanthomonadales S Spore Coat Protein U domain - - - - - - - - - - - - SCPU k59_719075_2 393595.ABO_0700 2.35e-07 53.5 COG3121@1|root,COG3121@2|Bacteria,1R4RJ@1224|Proteobacteria,1SDRF@1236|Gammaproteobacteria,1XQIA@135619|Oceanospirillales 135619|Oceanospirillales M Type 1 pili usher pathway chaperone CsuC - - - ko:K07346 - - - - ko00000,ko02035,ko02044,ko03110 - - - PapD_N k59_813860_1 643562.Daes_0789 1.61e-125 366.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2MEMH@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - DmsC,Fer4_11,Fer4_4 k59_423864_1 1500893.JQNB01000001_gene2929 1.94e-115 355.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1X4F7@135614|Xanthomonadales 135614|Xanthomonadales D Cell division protein ftsk ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - Cupin_4,FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1012952_1 580332.Slit_0297 6.43e-11 62.0 COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,2VQ90@28216|Betaproteobacteria,44W5P@713636|Nitrosomonadales 28216|Betaproteobacteria H PFAM Methyltransferase type 12 - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1012952_2 768671.ThimaDRAFT_4595 8.98e-62 199.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RP6X@1236|Gammaproteobacteria,1WWZ7@135613|Chromatiales 135613|Chromatiales O PFAM peptidase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_63266_1 1121918.ARWE01000001_gene723 9.39e-33 131.0 COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,42MGH@68525|delta/epsilon subdivisions,2WK72@28221|Deltaproteobacteria,43S83@69541|Desulfuromonadales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon_1 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_488724_1 1168034.FH5T_12205 2.37e-139 419.0 COG0542@1|root,COG0542@2|Bacteria,4NGEM@976|Bacteroidetes,2FM5N@200643|Bacteroidia 976|Bacteroidetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_881470_1 1151117.AJLF01000001_gene1347 5.43e-26 107.0 COG4902@1|root,arCOG03957@2157|Archaea,2Y2WW@28890|Euryarchaeota,243M5@183968|Thermococci 183968|Thermococci S Uncharacterized protein domain (DUF2202) - - - - - - - - - - - - DUF2202 k59_881470_2 1500301.JQMF01000012_gene5375 3.79e-60 187.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,4BDY9@82115|Rhizobiaceae 28211|Alphaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_1045243_1 1298867.AUES01000051_gene4511 9.63e-56 199.0 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_97785_1 1317124.DW2_16626 1.96e-80 258.0 COG3563@1|root,COG3563@2|Bacteria,1MW0T@1224|Proteobacteria,2TTAJ@28211|Alphaproteobacteria,2XMDC@285107|Thioclava 28211|Alphaproteobacteria M Capsule polysaccharide biosynthesis protein kpsC - - ko:K07266 - - - - ko00000 - - - Capsule_synth k59_914611_1 40571.JOEA01000002_gene4886 7.44e-07 53.5 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4DXHP@85010|Pseudonocardiales 201174|Actinobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_261223_1 1121007.AUML01000010_gene3345 1.06e-60 209.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,4NEDE@976|Bacteroidetes,1HXCU@117743|Flavobacteriia,2YGIA@290174|Aquimarina 976|Bacteroidetes E Glycine cleavage system P-protein gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_784210_1 1168034.FH5T_06220 3.07e-115 343.0 COG0652@1|root,COG0652@2|Bacteria,4NMJF@976|Bacteroidetes,2FWT5@200643|Bacteroidia 976|Bacteroidetes O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - - - - - - - - - - - Pro_isomerase k59_1012981_1 1123399.AQVE01000002_gene2331 1.84e-105 314.0 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,462SE@72273|Thiotrichales 72273|Thiotrichales H ThiF family - - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_325358_1 1123247.AUIJ01000007_gene2805 9.2e-64 210.0 COG0527@1|root,COG0527@2|Bacteria,1MVSI@1224|Proteobacteria,2TQQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k59_261232_1 1046724.KB889919_gene201 3.39e-36 136.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,4663F@72275|Alteromonadaceae 1236|Gammaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - iECO103_1326.ECO103_1114 MVIN k59_750067_1 1249480.B649_08850 5.31e-25 110.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2YMZ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M N-acetylmuramoyl-L-alanine amidase amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_63298_1 1307761.L21SP2_0664 3.14e-40 140.0 COG3039@1|root,COG3039@2|Bacteria,2J9MX@203691|Spirochaetes 203691|Spirochaetes L Transposase - - - - - - - - - - - - DDE_Tnp_1_2,DUF772 k59_423909_2 242619.PG_1503 4.51e-35 130.0 COG0761@1|root,COG0761@2|Bacteria 2|Bacteria IM 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 k59_27308_1 1123360.thalar_02888 1.11e-53 185.0 COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2UQID@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - Cytochrome_B,FlpD k59_750079_1 1123401.JHYQ01000021_gene1041 2.02e-104 313.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,1RQPI@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Nucleotidyl transferase - - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_261257_1 1049564.TevJSym_ab00170 5.55e-92 281.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_980367_1 1485544.JQKP01000020_gene55 1.21e-25 102.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,44V8V@713636|Nitrosomonadales 28216|Betaproteobacteria M Nucleotidyl transferase rmlA - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_980367_2 929558.SMGD1_1027 1.43e-137 399.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,42TUJ@68525|delta/epsilon subdivisions,2YR6E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ecdysteroid kinase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_980367_3 1165841.SULAR_03123 3.51e-101 306.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,42RT7@68525|delta/epsilon subdivisions,2YRF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_881507_1 44251.PDUR_25900 2.04e-17 81.3 COG3415@1|root,COG3415@2|Bacteria,1VHWW@1239|Firmicutes,4I7ZS@91061|Bacilli,26YD3@186822|Paenibacillaceae 91061|Bacilli L Homeodomain-like domain - - - - - - - - - - - - HTH_32 k59_881507_2 1499967.BAYZ01000082_gene1020 1.43e-90 270.0 COG3335@1|root,COG3335@2|Bacteria,2NRUG@2323|unclassified Bacteria 2|Bacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_914650_1 472759.Nhal_0903 6.92e-81 264.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales 135613|Chromatiales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_63305_2 479435.Kfla_4699 1.01e-20 99.4 COG0584@1|root,COG0584@2|Bacteria,2GNM5@201174|Actinobacteria,4DRS8@85009|Propionibacteriales 201174|Actinobacteria C glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - DUF1080,GDPD k59_63305_3 367737.Abu_1443 8.35e-24 99.8 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2YNXT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M (Lipo)protein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_261274_1 2340.JV46_25910 1.35e-20 84.7 COG2920@1|root,COG2920@2|Bacteria,1RJMD@1224|Proteobacteria,1S8EM@1236|Gammaproteobacteria 1236|Gammaproteobacteria P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_261279_1 1265502.KB905972_gene1332 1.02e-102 308.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria,4AFGR@80864|Comamonadaceae 28216|Betaproteobacteria Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_852042_5 572544.Ilyop_1445 1.94e-08 55.1 2D2T0@1|root,32TDI@2|Bacteria,37AQZ@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_852042_6 572544.Ilyop_1444 7.88e-25 99.8 2CGJQ@1|root,311NS@2|Bacteria,37AET@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_852042_7 572544.Ilyop_0443 1.28e-233 650.0 COG1509@1|root,COG1509@2|Bacteria,37952@32066|Fusobacteria 32066|Fusobacteria C Lysine-2,3-aminomutase ablA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,LAM_C,Radical_SAM k59_852042_8 1026882.MAMP_02151 7.65e-10 58.5 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,460MN@72273|Thiotrichales 72273|Thiotrichales S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_884332_1 1033810.HLPCO_001456 7.8e-83 259.0 COG1473@1|root,COG1473@2|Bacteria,2NPHI@2323|unclassified Bacteria 2|Bacteria S Peptidase dimerisation domain dapL - 3.5.1.47 ko:K05823,ko:K21613 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00525 R02733 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_884332_2 1263831.F543_17170 4.58e-14 69.3 COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1Y9C5@135625|Pasteurellales 135625|Pasteurellales C acylphosphatase activity acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_884332_3 469618.FVAG_01755 1.25e-301 830.0 COG0519@1|root,COG0519@2|Bacteria,3785K@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_884332_4 1319815.HMPREF0202_01393 3.06e-268 744.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,378I3@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_884332_5 666686.B1NLA3E_12645 3.25e-139 414.0 COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,4HBB2@91061|Bacilli,1ZCHI@1386|Bacillus 91061|Bacilli F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade GO:0003674,GO:0003824,GO:0006040,GO:0006044,GO:0006046,GO:0008150,GO:0008152,GO:0008448,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - iYO844.BSU14520 Adenine_deam_C,Amidohydro_1 k59_884332_6 1340434.AXVA01000017_gene4125 2.86e-22 97.4 COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,4HBB2@91061|Bacilli,1ZCHI@1386|Bacillus 91061|Bacilli F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade GO:0003674,GO:0003824,GO:0006040,GO:0006044,GO:0006046,GO:0008150,GO:0008152,GO:0008448,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - iYO844.BSU14520 Adenine_deam_C,Amidohydro_1 k59_361735_1 1165841.SULAR_02993 7.83e-115 333.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,42PC4@68525|delta/epsilon subdivisions,2YP8E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C radicals which are normally produced within the cells and which are toxic to biological systems sodB GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_361735_2 387093.SUN_1698 7.82e-37 132.0 COG4123@1|root,COG4123@2|Bacteria,1RDSC@1224|Proteobacteria,42RIN@68525|delta/epsilon subdivisions,2YP8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S methyltransferase - - - - - - - - - - - - MTS k59_1482_2 29760.VIT_08s0056g00590.t01 1.37e-124 360.0 28IB5@1|root,2QV51@2759|Eukaryota,37SP0@33090|Viridiplantae,3GHPJ@35493|Streptophyta 35493|Streptophyta U May be involved in proton extrusion. Indirectly promotes efficient inorganic carbon uptake cemA - - - - - - - - - - - CemA k59_950027_1 1168034.FH5T_06500 1.98e-36 132.0 COG2876@1|root,COG2876@2|Bacteria,4NDU4@976|Bacteroidetes,2FPF1@200643|Bacteroidia 976|Bacteroidetes E 3-deoxy-7-phosphoheptulonate synthase pheB - 5.4.99.5 ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,DAHP_synth_1 k59_950027_2 1168034.FH5T_04805 3.01e-56 190.0 COG2866@1|root,COG2866@2|Bacteria,4NF5T@976|Bacteroidetes 976|Bacteroidetes E Carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_753660_1 1322246.BN4_12706 2.71e-07 57.8 COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,42Y97@68525|delta/epsilon subdivisions,2WTJS@28221|Deltaproteobacteria,2MAZV@213115|Desulfovibrionales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,dCache_1 k59_982518_1 190650.CC_1796 8.79e-42 154.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,2KHEW@204458|Caulobacterales 204458|Caulobacterales L Transposase DDE domain - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1_6,DUF772 k59_426780_1 694431.DESACE_04715 7.28e-40 145.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NV6@68525|delta/epsilon subdivisions,2WIPB@28221|Deltaproteobacteria,2M74R@213113|Desulfurellales 28221|Deltaproteobacteria E Aminotransferase class I and II - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_1015257_1 1304885.AUEY01000009_gene1952 6.64e-11 67.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42MBK@68525|delta/epsilon subdivisions,2WKDV@28221|Deltaproteobacteria,2MINH@213118|Desulfobacterales 28221|Deltaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_917449_1 709991.Odosp_1885 4.03e-51 178.0 COG1834@1|root,COG1834@2|Bacteria,4NKBZ@976|Bacteroidetes,2G3EW@200643|Bacteroidia,22Z8A@171551|Porphyromonadaceae 976|Bacteroidetes E Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_819183_1 929558.SMGD1_2667 3.33e-72 236.0 COG0008@1|root,COG0064@1|root,COG0008@2|Bacteria,COG0064@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2YNBY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J PFAM tRNA synthetases class I (E and Q), catalytic domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C k59_819183_2 1380358.JADJ01000003_gene4553 2.09e-22 91.7 COG3070@1|root,COG3070@2|Bacteria,1RDWD@1224|Proteobacteria,1S496@1236|Gammaproteobacteria 1236|Gammaproteobacteria K regulator of competence-specific genes sxy GO:0006355,GO:0006810,GO:0007154,GO:0008150,GO:0009290,GO:0009292,GO:0009294,GO:0009605,GO:0009889,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0015931,GO:0019219,GO:0019222,GO:0030420,GO:0031323,GO:0031326,GO:0031344,GO:0031346,GO:0031668,GO:0044087,GO:0044089,GO:0044093,GO:0044764,GO:0048518,GO:0048522,GO:0050657,GO:0050789,GO:0050794,GO:0050896,GO:0051027,GO:0051090,GO:0051091,GO:0051128,GO:0051130,GO:0051171,GO:0051179,GO:0051234,GO:0051252,GO:0051704,GO:0051716,GO:0060255,GO:0060491,GO:0065007,GO:0065009,GO:0071496,GO:0071702,GO:0071705,GO:0080090,GO:0098657,GO:1903506,GO:1903656,GO:1903658,GO:2000112,GO:2001141 - ko:K07343 - - - - ko00000 - - - TfoX_C,TfoX_N k59_982529_1 929558.SMGD1_2822 7.3e-47 161.0 COG1502@1|root,COG1502@2|Bacteria,1R51A@1224|Proteobacteria,42PGS@68525|delta/epsilon subdivisions,2YNQ6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I ORF6N domain - - - - - - - - - - - - ORF6N k59_852064_1 2340.JV46_24290 3.44e-142 410.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Hydrogenase formation hypA family hypD GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - ko:K04654 - - - - ko00000 - - - HypD k59_753678_1 713587.THITH_12345 2.09e-34 119.0 COG4576@1|root,COG4576@2|Bacteria,1N7B1@1224|Proteobacteria,1S9JX@1236|Gammaproteobacteria,1WZ5P@135613|Chromatiales 135613|Chromatiales CQ Ethanolamine utilisation protein EutN/carboxysome - - - - - - - - - - - - EutN_CcmL k59_753678_2 765912.Thimo_2951 2.5e-42 139.0 COG4576@1|root,COG4576@2|Bacteria,1MZNS@1224|Proteobacteria,1S9MK@1236|Gammaproteobacteria,1WYX9@135613|Chromatiales 135613|Chromatiales CQ PFAM Ethanolamine utilization protein EutN carboxysome structural protein Ccml - - - - - - - - - - - - EutN_CcmL k59_165544_1 1235802.C823_01208 3.46e-16 82.8 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - AP_endonuc_2,Glyco_tranf_2_4,Glyco_transf_7C,Glycos_transf_2 k59_165544_2 1172562.HCN_1122 1.89e-41 147.0 COG1045@1|root,COG1045@2|Bacteria,1RAX4@1224|Proteobacteria,430FC@68525|delta/epsilon subdivisions,2YS3B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E serine acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_165544_3 1280664.AUIX01000007_gene3349 0.000503 50.4 COG3980@1|root,COG3980@2|Bacteria,1V5D5@1239|Firmicutes,24G0D@186801|Clostridia,4BY38@830|Butyrivibrio 186801|Clostridia M spore coat polysaccharide biosynthesis protein - - - - - - - - - - - - Glyco_tran_28_C k59_165544_4 431943.CKL_2109 1.5e-65 217.0 COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,249DN@186801|Clostridia,36F2S@31979|Clostridiaceae 186801|Clostridia M synthase pseI - 2.5.1.56,2.5.1.97 ko:K01654,ko:K15898 ko00520,ko01100,map00520,map01100 - R01804,R04435,R09841 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_165544_5 1122135.KB893157_gene139 7.31e-57 186.0 COG0110@1|root,COG0110@2|Bacteria,1RAKB@1224|Proteobacteria,2U3JX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial transferase hexapeptide (six repeats) - - - - - - - - - - - - Hexapep k59_165544_6 1288494.EBAPG3_27190 3.02e-82 255.0 COG4122@1|root,COG4122@2|Bacteria,1RDQ2@1224|Proteobacteria,2VSV7@28216|Betaproteobacteria 28216|Betaproteobacteria S Macrocin-O-methyltransferase (TylF) - - - - - - - - - - - - TylF k59_165544_7 999611.KI421504_gene1684 1.34e-39 148.0 COG1621@1|root,COG1621@2|Bacteria,1N5AZ@1224|Proteobacteria,2U950@28211|Alphaproteobacteria 28211|Alphaproteobacteria G beta-fructofuranosidase activity - - - - - - - - - - - - - k59_165544_8 1282360.ABAC460_02285 1.1e-50 171.0 COG4122@1|root,COG4122@2|Bacteria,1NIE0@1224|Proteobacteria,2TWER@28211|Alphaproteobacteria 28211|Alphaproteobacteria S WbqC-like protein family - - - - - - - - - - - - WbqC k59_165544_9 570268.ANBB01000033_gene2076 1.29e-06 55.8 COG0500@1|root,COG2226@2|Bacteria,2GQ64@201174|Actinobacteria,4EFW5@85012|Streptosporangiales 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_165544_10 1167006.UWK_02416 1.59e-39 143.0 COG1083@1|root,COG1083@2|Bacteria,1QACI@1224|Proteobacteria,42QBP@68525|delta/epsilon subdivisions,2WNRH@28221|Deltaproteobacteria,2MKJ6@213118|Desulfobacterales 28221|Deltaproteobacteria M Cytidylyltransferase neuA - 2.7.7.43 ko:K00983 ko00520,ko01100,map00520,map01100 - R01117,R04215 RC00152 ko00000,ko00001,ko01000 - - - CTP_transf_3 k59_165544_11 1244869.H261_18457 5.93e-43 158.0 COG0673@1|root,COG0673@2|Bacteria,1Q8R1@1224|Proteobacteria,2U8HN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_165544_12 1163617.SCD_n02898 9.69e-187 532.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 1.17.1.1 ko:K12452 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 k59_165544_13 485917.Phep_3937 3.92e-56 182.0 COG1670@1|root,COG1670@2|Bacteria,4NN0F@976|Bacteroidetes,1IUFM@117747|Sphingobacteriia 976|Bacteroidetes J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_165544_15 929558.SMGD1_0511 4.5e-156 462.0 COG3563@1|root,COG3563@2|Bacteria 2|Bacteria M Capsule polysaccharide - - - - - - - - - - - - - k59_165544_16 1232437.KL662017_gene527 9.16e-77 249.0 COG2227@1|root,COG2227@2|Bacteria,1RCSH@1224|Proteobacteria,42ZUJ@68525|delta/epsilon subdivisions,2WVEK@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_165544_17 118168.MC7420_7338 2.78e-67 219.0 2DTTJ@1|root,32UVW@2|Bacteria,1G8TS@1117|Cyanobacteria,1HCTF@1150|Oscillatoriales 1117|Cyanobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_165544_18 357808.RoseRS_3583 1.77e-22 105.0 COG0438@1|root,COG0438@2|Bacteria,2G61I@200795|Chloroflexi,3753V@32061|Chloroflexia 32061|Chloroflexia M PFAM glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_165544_19 1249975.JQLP01000005_gene1665 7e-36 135.0 COG1216@1|root,COG1216@2|Bacteria,4NGHQ@976|Bacteroidetes,1HZWP@117743|Flavobacteriia,2P7A2@244698|Gillisia 976|Bacteroidetes S Glycosyltransferase like family 2 - - - ko:K13002 - - - - ko00000,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_2 k59_165544_20 81985.XP_006302493.1 3.6e-08 62.4 COG0451@1|root,KOG1502@2759|Eukaryota,37J0J@33090|Viridiplantae,3GMZ4@35493|Streptophyta,3HXGX@3699|Brassicales 35493|Streptophyta V cinnamyl-alcohol dehydrogenase - - - - - - - - - - - - 3Beta_HSD,Epimerase k59_165544_21 204773.HEAR1144 3.02e-95 296.0 COG0438@1|root,COG0438@2|Bacteria,1MWEM@1224|Proteobacteria,2VKRY@28216|Betaproteobacteria,47657@75682|Oxalobacteraceae 28216|Betaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_950053_2 1121451.DESAM_20190 9.55e-42 152.0 COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2M8S3@213115|Desulfovibrionales 28221|Deltaproteobacteria J PFAM RNA binding S1 domain protein - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_361765_1 765910.MARPU_04845 4.22e-53 185.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales 135613|Chromatiales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_394294_1 1304885.AUEY01000001_gene3312 4.83e-86 274.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales 28221|Deltaproteobacteria S pfam abc-1 - - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_198062_1 870187.Thini_2509 6.54e-108 327.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,45ZP9@72273|Thiotrichales 72273|Thiotrichales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_950056_1 1168034.FH5T_05805 1.89e-91 281.0 COG0673@1|root,COG0673@2|Bacteria,4NG5T@976|Bacteroidetes,2FPA2@200643|Bacteroidia 976|Bacteroidetes S Putative oxidoreductase C terminal domain - - - - - - - - - - - - GFO_IDH_MocA,Oxidoreduct_C k59_917476_1 1168034.FH5T_20730 7.1e-159 456.0 COG0059@1|root,COG0059@2|Bacteria,4NFYV@976|Bacteroidetes,2FN0U@200643|Bacteroidia 976|Bacteroidetes E Ketol-acid reductoisomerase ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_656017_1 640081.Dsui_3244 2.71e-47 160.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2VJEI@28216|Betaproteobacteria,2KWJH@206389|Rhodocyclales 206389|Rhodocyclales F Glutamine amidotransferase class-I - - - - - - - - - - - - GATase k59_590428_1 1537917.JU82_03185 4.77e-39 133.0 COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,42U9K@68525|delta/epsilon subdivisions,2YQ3Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_590428_2 1328313.DS2_02710 5.23e-59 203.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,467E9@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0025 NhaP-type Na H and K H antiporters - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,cNMP_binding k59_950060_1 215803.DB30_3065 2.29e-147 432.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria,2YXXC@29|Myxococcales 28221|Deltaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_230929_1 76114.ebA3623 1.12e-77 243.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2VHD1@28216|Betaproteobacteria,2KVBD@206389|Rhodocyclales 206389|Rhodocyclales C Alanine dehydrogenase/PNT, N-terminal domain - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_34422_2 1408422.JHYF01000006_gene1285 2.88e-231 653.0 COG4670@1|root,COG4670@2|Bacteria,1TP5H@1239|Firmicutes,247ZG@186801|Clostridia,36DYM@31979|Clostridiaceae 186801|Clostridia I Belongs to the 3-oxoacid CoA-transferase family - - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_34422_3 1319815.HMPREF0202_01673 1.49e-30 108.0 2DNM3@1|root,32Y2K@2|Bacteria,37AV7@32066|Fusobacteria 32066|Fusobacteria S Hydrid cluster protein-associated redox disulfide domain protein - - - - - - - - - - - - DUF1858 k59_34422_4 1408439.JHXW01000003_gene1543 9.62e-137 397.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,3786Q@32066|Fusobacteria 32066|Fusobacteria M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_917488_1 1304284.L21TH_1617 2.83e-85 258.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,36EDS@31979|Clostridiaceae 186801|Clostridia I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_917488_2 572544.Ilyop_0935 7.68e-48 160.0 28H5W@1|root,2Z7IF@2|Bacteria,379JJ@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_132878_1 583345.Mmol_1297 2.82e-16 79.3 COG1714@1|root,COG1714@2|Bacteria 2|Bacteria S RDD family - - - - - - - - - - - - DUF4339,RDD k59_459848_1 1168289.AJKI01000004_gene2941 1.48e-39 142.0 COG3385@1|root,COG3385@2|Bacteria,4NX1P@976|Bacteroidetes,2FURU@200643|Bacteroidia 976|Bacteroidetes L COG COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - - k59_525136_1 717605.Theco_3263 1.91e-18 89.7 COG3409@1|root,COG3409@2|Bacteria,1UWKK@1239|Firmicutes,4HBYN@91061|Bacilli,26VEM@186822|Paenibacillaceae 91061|Bacilli M Copper amine oxidase N-terminal domain - - - - - - - - - - - - Cu_amine_oxidN1 k59_656051_1 247639.MGP2080_02745 1.44e-79 246.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0501 Zn-dependent protease with chaperone function Z012_09445 - - - - - - - - - - - Peptidase_M48 k59_492434_1 439235.Dalk_2075 7.08e-07 56.2 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MMRD@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_1524_1 1304865.JAGF01000001_gene2181 7.98e-129 372.0 COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,4F2B1@85016|Cellulomonadaceae 201174|Actinobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_688555_1 237368.SCABRO_00579 2.71e-46 162.0 COG1639@1|root,COG1639@2|Bacteria,2J0A1@203682|Planctomycetes 203682|Planctomycetes T HDOD domain - - - - - - - - - - - - HDOD k59_917516_1 911045.PSE_0614 1.14e-106 315.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_426836_1 439235.Dalk_1358 4.65e-77 241.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,42MZM@68525|delta/epsilon subdivisions,2WJG6@28221|Deltaproteobacteria,2MJ01@213118|Desulfobacterales 28221|Deltaproteobacteria S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_754200_1 1501391.LG35_09105 2.35e-62 207.0 COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,2FNXM@200643|Bacteroidia,22UD9@171550|Rikenellaceae 976|Bacteroidetes S von Willebrand factor type A domain batA - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA k59_492969_1 36630.CADNFIAP00000043 4.19e-13 69.7 COG4359@1|root,2QW23@2759|Eukaryota,38PDP@33154|Opisthokonta,3NWQH@4751|Fungi,3QMUS@4890|Ascomycota,20AEY@147545|Eurotiomycetes,3S7B4@5042|Eurotiales 4751|Fungi E 23-diketo-5-methylthio-1-phosphopentane phosphatase - - - - - - - - - - - - HAD k59_492969_2 572544.Ilyop_0591 3.05e-34 120.0 COG0721@1|root,COG0721@2|Bacteria,37APP@32066|Fusobacteria 32066|Fusobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_492969_3 1408439.JHXW01000002_gene765 1.75e-90 280.0 COG0154@1|root,COG0154@2|Bacteria,3783S@32066|Fusobacteria 32066|Fusobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_689111_1 1249480.B649_11315 1.01e-82 256.0 COG0577@1|root,COG0577@2|Bacteria,1QT4V@1224|Proteobacteria,42P7K@68525|delta/epsilon subdivisions,2YNGD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter permease - - - - - - - - - - - - FtsX,MacB_PCD k59_983077_1 717773.Thicy_0093 1.29e-14 79.3 COG3203@1|root,COG3203@2|Bacteria,1RKZ1@1224|Proteobacteria,1SWVR@1236|Gammaproteobacteria,4627Z@72273|Thiotrichales 72273|Thiotrichales M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_983077_2 1049564.TevJSym_aj00410 0.0 1065.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1J51W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1032 Fe-S oxidoreductase ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_983077_3 1049564.TevJSym_ab00060 1.1e-146 422.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,1RPS1@1236|Gammaproteobacteria,1J4FK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0835 Chemotaxis signal transduction protein cheV - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_983077_4 1049564.TevJSym_bd00040 2.92e-185 528.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1J515@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Flavocytochrome c sulphide dehydrogenase, flavin-binding fccB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_983077_5 870187.Thini_1238 3.16e-28 114.0 COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria,462T6@72273|Thiotrichales 72273|Thiotrichales C Cytochrome c class I - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_983077_6 396588.Tgr7_0038 5.36e-193 550.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1X04M@135613|Chromatiales 135613|Chromatiales T Sigma-54 interaction domain - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_983077_7 555778.Hneap_2069 2.5e-121 381.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RWW8@1236|Gammaproteobacteria,1X085@135613|Chromatiales 135613|Chromatiales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_983077_10 1415778.JQMM01000001_gene1035 1.15e-48 162.0 COG3091@1|root,COG3091@2|Bacteria,1N07A@1224|Proteobacteria,1S9E8@1236|Gammaproteobacteria,1J74J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S SprT homologues. sprT - - ko:K02742 - - - - ko00000 - - - SprT-like,Zn_ribbon_SprT k59_983077_11 396588.Tgr7_0930 1.09e-200 565.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales 135613|Chromatiales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_983077_12 1049564.TevJSym_av00120 1.32e-285 789.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1J4HM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125 GATase_6,GATase_7,Pribosyltran k59_983077_13 1163409.UUA_03578 9.25e-43 148.0 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1X6XU@135614|Xanthomonadales 135614|Xanthomonadales S membrane protein, required for colicin V production - - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_983077_14 1049564.TevJSym_ar00050 8.67e-18 84.3 COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1J6N7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sporulation related domain dedD - - ko:K03749 - - - - ko00000 - - - SPOR k59_501738_2 749222.Nitsa_0697 4.52e-105 310.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2YMQ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_892959_1 1198232.CYCME_1027 1.48e-247 698.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,4608E@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_42416_1 562970.Btus_2595 5.94e-54 181.0 COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,4HAGM@91061|Bacilli,27810@186823|Alicyclobacillaceae 91061|Bacilli H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_271659_2 925409.KI911562_gene155 1.64e-32 122.0 COG0640@1|root,COG0640@2|Bacteria,4NS23@976|Bacteroidetes,1IT8B@117747|Sphingobacteriia 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - HTH_DeoR k59_271659_3 1168034.FH5T_21385 2.8e-17 82.4 COG1596@1|root,COG1596@2|Bacteria,4NEXJ@976|Bacteroidetes,2FM4E@200643|Bacteroidia 976|Bacteroidetes M Polysaccharide biosynthesis export protein kpsD_1 - - - - - - - - - - - Caps_synth_GfcC,Poly_export,SLBB k59_304372_1 1537917.JU82_05780 6.15e-90 269.0 COG0745@1|root,COG0745@2|Bacteria,1Q5DC@1224|Proteobacteria,42R42@68525|delta/epsilon subdivisions,2YNXG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_304372_2 273121.WS0901 1.54e-29 119.0 COG0642@1|root,COG3287@1|root,COG0642@2|Bacteria,COG3287@2|Bacteria,1NXDJ@1224|Proteobacteria,43CBD@68525|delta/epsilon subdivisions,2YQE7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T FIST N domain - - - - - - - - - - - - FIST,FIST_C,HATPase_c,HisKA k59_7113_1 1223410.KN050846_gene167 5.43e-115 349.0 COG1200@1|root,COG1200@2|Bacteria,4NDZV@976|Bacteroidetes,1HX1Z@117743|Flavobacteriia 976|Bacteroidetes L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_893641_2 1317124.DW2_15260 1.71e-27 109.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,2XKYX@285107|Thioclava 28211|Alphaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_240001_1 207559.Dde_1623 2.22e-19 90.9 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42NCC@68525|delta/epsilon subdivisions,2WJRS@28221|Deltaproteobacteria,2M80W@213115|Desulfovibrionales 28221|Deltaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_893642_1 2340.JV46_13920 6.81e-11 65.5 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria,1JAHU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_42418_1 1165841.SULAR_05518 4.04e-140 418.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2YN4X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal-transduction protein containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_240002_1 445974.CLORAM_02851 1.33e-06 50.4 COG2508@1|root,COG2508@2|Bacteria,1TSQP@1239|Firmicutes,3VQ2B@526524|Erysipelotrichia 526524|Erysipelotrichia QT Purine catabolism regulatory protein-like family - - - - - - - - - - - - HTH_30,PucR k59_697561_1 944547.ABLL_1609 6.19e-15 73.2 COG0189@1|root,COG0189@2|Bacteria,1R4ZF@1224|Proteobacteria,42PG3@68525|delta/epsilon subdivisions,2YMQ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_697561_2 1123326.JFBL01000007_gene638 2.23e-126 373.0 COG0189@1|root,COG1555@1|root,COG0189@2|Bacteria,COG1555@2|Bacteria,1R8K6@1224|Proteobacteria,43A4Z@68525|delta/epsilon subdivisions,2YNII@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - - - - - - - - - - - HHH_3,HHH_5,RimK k59_958767_1 351348.Maqu_3599 1.85e-55 186.0 COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,464NU@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG2951 Membrane-bound lytic murein transglycosylase B - - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - PG_binding_1,SLT_2 k59_403138_1 580332.Slit_0904 7.29e-17 80.9 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,2VJNA@28216|Betaproteobacteria,44W97@713636|Nitrosomonadales 28216|Betaproteobacteria C Nitrogenase component 1 type Oxidoreductase nifN - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_403138_2 1249627.D779_2018 6.97e-33 119.0 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,1S50W@1236|Gammaproteobacteria,1WY7T@135613|Chromatiales 135613|Chromatiales S PFAM Dinitrogenase iron-molybdenum cofactor - - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_893653_1 85643.Tmz1t_2255 2.42e-37 138.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,2KUYX@206389|Rhodocyclales 206389|Rhodocyclales L uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_893653_2 387093.SUN_1453 5.62e-67 212.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2YN72@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM Radical SAM domain protein - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_567400_1 1026882.MAMP_00291 1.04e-62 195.0 2E1WQ@1|root,32X5W@2|Bacteria,1N2F8@1224|Proteobacteria,1SA2N@1236|Gammaproteobacteria,462KZ@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_567400_2 1026882.MAMP_02779 3.61e-11 62.4 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII - - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - DUF4113,IMS,IMS_C k59_600043_2 1249480.B649_06875 6.03e-46 151.0 2BR28@1|root,32K00@2|Bacteria,1Q2JJ@1224|Proteobacteria,42VUT@68525|delta/epsilon subdivisions,2YQF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S NifQ - - - ko:K15790 - - - - ko00000 - - - NifQ k59_600043_3 1249480.B649_06870 1.89e-74 231.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42VWM@68525|delta/epsilon subdivisions,2YQKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0714 MoxR-like - - - - - - - - - - - - AAA_5 k59_109760_1 1298593.TOL_1398 5.31e-22 93.6 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,1XHNM@135619|Oceanospirillales 135619|Oceanospirillales C Part of a membrane complex involved in electron transport rnfE - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_109760_2 1049564.TevJSym_br00050 1.07e-23 100.0 COG4659@1|root,COG4659@2|Bacteria,1R6FE@1224|Proteobacteria,1RYZ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_207834_1 187272.Mlg_1890 4.07e-47 167.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_207834_2 1279017.AQYJ01000024_gene868 1.63e-30 111.0 COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,4688I@72275|Alteromonadaceae 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_665749_2 1121015.N789_13405 2.21e-47 157.0 COG1846@1|root,COG1846@2|Bacteria,1N1CJ@1224|Proteobacteria,1SCUJ@1236|Gammaproteobacteria,1X6IP@135614|Xanthomonadales 135614|Xanthomonadales K MarR family transcriptional regulator - - - - - - - - - - - - MarR_2 k59_665749_3 1411685.U062_01822 1.02e-09 58.5 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1J58Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_502515_1 1042377.AFPJ01000028_gene2306 2.88e-54 191.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,46544@72275|Alteromonadaceae 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_632708_1 879212.DespoDRAFT_03566 1.69e-137 402.0 COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria 1224|Proteobacteria S Involved in initiation control of chromosome replication - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66 k59_339288_1 553219.CAMSH0001_0930 4.75e-64 217.0 COG0699@1|root,COG0699@2|Bacteria 2|Bacteria T ATPase. Has a role at an early stage in the morphogenesis of the spore coat - - - - - - - - - - - - Dynamin_N k59_665751_1 247634.GPB2148_3260 3.21e-92 275.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_143123_1 999611.KI421504_gene3428 4.46e-39 141.0 COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2U4IW@28211|Alphaproteobacteria,2810U@191028|Leisingera 28211|Alphaproteobacteria S Predicted metal-binding integral membrane protein (DUF2182) - - - - - - - - - - - - DUF2182 k59_535209_1 595460.RRSWK_03372 1.74e-39 149.0 COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2IZND@203682|Planctomycetes 203682|Planctomycetes K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_927170_2 1123401.JHYQ01000015_gene1412 5.28e-27 102.0 2E0WU@1|root,32VAZ@2|Bacteria,1N42K@1224|Proteobacteria,1S97C@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_697590_1 543728.Vapar_4609 1.81e-75 236.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2VKR0@28216|Betaproteobacteria,4AK38@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - Cupin_6,HTH_18 k59_175353_1 1168034.FH5T_08670 3.03e-104 330.0 COG0060@1|root,COG0060@2|Bacteria,4NEYT@976|Bacteroidetes,2FM5R@200643|Bacteroidia 976|Bacteroidetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_240037_1 1121937.AUHJ01000050_gene1242 8.37e-114 337.0 COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,1RQQA@1236|Gammaproteobacteria,467IJ@72275|Alteromonadaceae 1236|Gammaproteobacteria L zinc-finger of transposase IS204/IS1001/IS1096/IS1165 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_240039_1 1565314.OA34_02845 9.03e-69 233.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2YMRQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_600068_1 1379698.RBG1_1C00001G0122 1.99e-86 273.0 COG1070@1|root,COG1070@2|Bacteria,2NP2A@2323|unclassified Bacteria 2|Bacteria G MutL protein - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N,MutL k59_175366_1 929556.Solca_1565 4.92e-40 146.0 COG2804@1|root,COG2804@2|Bacteria,4NHT2@976|Bacteroidetes,1INRZ@117747|Sphingobacteriia 976|Bacteroidetes NU Type II IV secretion system protein gspE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_958814_1 1415779.JOMH01000001_gene3016 9.47e-64 220.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5MD@135614|Xanthomonadales 135614|Xanthomonadales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_600073_1 933262.AXAM01000077_gene1702 2.94e-15 75.9 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2MJ0H@213118|Desulfobacterales 28221|Deltaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_600073_2 933262.AXAM01000077_gene1703 1.59e-42 151.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria,2MJ2C@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_240048_1 387093.SUN_1107 1.17e-80 266.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2YMHU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_371192_2 114615.BRADO5815 1.81e-09 64.7 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,2TW4K@28211|Alphaproteobacteria,3JR1W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_600082_2 587753.EY04_11830 9.5e-58 195.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria 1236|Gammaproteobacteria P import. Responsible for energy coupling to the transport system - - - ko:K17215 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - ABC_tran k59_729473_1 1121422.AUMW01000010_gene1159 5.06e-83 259.0 COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,26072@186807|Peptococcaceae 186801|Clostridia H PFAM Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_339327_1 765913.ThidrDRAFT_1253 1.74e-32 124.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1WWKF@135613|Chromatiales 135613|Chromatiales O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_958826_1 1168034.FH5T_11800 2.56e-151 440.0 COG0204@1|root,COG0204@2|Bacteria,4NN7X@976|Bacteroidetes,2FUAF@200643|Bacteroidia 976|Bacteroidetes I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_665781_1 1165841.SULAR_07760 6.78e-137 394.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2YN3F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_665781_2 1165841.SULAR_07765 9.25e-161 456.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2YMMK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_1024143_1 984262.SGRA_0462 1.22e-38 141.0 COG3488@1|root,COG3488@2|Bacteria,4NGBS@976|Bacteroidetes,1IWE8@117747|Sphingobacteriia 976|Bacteroidetes C Di-haem oxidoreductase, putative peroxidase - - - - - - - - - - - - DHOR k59_729477_1 1168034.FH5T_05175 3.58e-57 182.0 COG2010@1|root,COG2010@2|Bacteria,4NKQI@976|Bacteroidetes 976|Bacteroidetes C Cytochrome C actE - - - - - - - - - - - Cytochrome_CBB3 k59_729477_2 1168034.FH5T_05180 2.22e-40 143.0 COG4531@1|root,COG4531@2|Bacteria,4NF0R@976|Bacteroidetes 976|Bacteroidetes P Quinol cytochrome c oxidoreductase actF - - - - - - - - - - - - k59_175386_1 992406.RIA_1638 0.000155 43.9 COG1044@1|root,COG1044@2|Bacteria,4NE5G@976|Bacteroidetes,1HWJD@117743|Flavobacteriia 976|Bacteroidetes M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_175386_2 1168034.FH5T_05040 1.77e-119 353.0 COG1078@1|root,COG1078@2|Bacteria,4NE1T@976|Bacteroidetes,2FMCR@200643|Bacteroidia 976|Bacteroidetes S HD domain protein - - - ko:K06885 - - - - ko00000 - - - HD k59_1024147_2 1265505.ATUG01000003_gene361 7.07e-14 71.2 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MHQW@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_403201_1 215803.DB30_1496 0.000252 52.0 COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1NIID@1224|Proteobacteria,42YIQ@68525|delta/epsilon subdivisions,2WUCK@28221|Deltaproteobacteria,2YTXX@29|Myxococcales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_76981_1 400668.Mmwyl1_4445 1.02e-15 75.9 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,1XH9R@135619|Oceanospirillales 135619|Oceanospirillales E Aminotransferase - - 2.6.1.1,2.6.1.57 ko:K00813,ko:K00832 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 M00024,M00025,M00034,M00040 R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_76981_2 744872.Spica_0834 1.47e-48 169.0 COG0105@1|root,COG0105@2|Bacteria,2J5M6@203691|Spirochaetes 203691|Spirochaetes F Nucleoside diphosphate kinase - - - - - - - - - - - - NDK k59_828394_1 1341155.FSS13T_21560 1.53e-70 232.0 COG0535@1|root,COG0535@2|Bacteria,4NQ4R@976|Bacteroidetes 976|Bacteroidetes C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_828394_2 927658.AJUM01000034_gene567 4.6e-56 190.0 29X8I@1|root,30IXV@2|Bacteria,4P0MB@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_339343_1 1123256.KB907937_gene1872 4.56e-67 220.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1X3CI@135614|Xanthomonadales 135614|Xanthomonadales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_109812_1 933262.AXAM01000096_gene2623 6.25e-109 332.0 COG3039@1|root,COG3039@2|Bacteria,1R6NB@1224|Proteobacteria,42RBZ@68525|delta/epsilon subdivisions,2WMWZ@28221|Deltaproteobacteria,2MQ2G@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_893716_1 888727.HMPREF9092_1090 1.04e-15 74.7 COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,3WDJD@538999|Clostridiales incertae sedis 186801|Clostridia S Belongs to the UPF0109 family ylqC - - ko:K06960 - - - - ko00000 - - - KH_4 k59_893716_4 1469948.JPNB01000001_gene1539 3.49e-38 143.0 COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,36EJ7@31979|Clostridiaceae 186801|Clostridia J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_958847_1 1168034.FH5T_07310 7.1e-21 92.0 COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,2FNAU@200643|Bacteroidia 976|Bacteroidetes M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_958847_2 243230.DR_1374 7.7e-06 47.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1WJ8E@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_435407_1 644968.DFW101_3679 2.64e-72 234.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42NVU@68525|delta/epsilon subdivisions,2WMH6@28221|Deltaproteobacteria,2MARK@213115|Desulfovibrionales 28221|Deltaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.111,5.4.3.8 ko:K01845,ko:K07257,ko:K21585 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272,R11607 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,CTP_transf_3 k59_729496_1 351348.Maqu_3694 5.95e-20 89.7 COG4067@1|root,COG4067@2|Bacteria,1N7Y2@1224|Proteobacteria,1SARP@1236|Gammaproteobacteria,46CT7@72275|Alteromonadaceae 1236|Gammaproteobacteria O protein conserved in archaea - - - - - - - - - - - - Zn_protease k59_697651_1 1000565.METUNv1_01595 1.41e-35 127.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,2KX2W@206389|Rhodocyclales 206389|Rhodocyclales P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH k59_697651_2 1123487.KB892857_gene2393 3.05e-05 50.4 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,2KW7Q@206389|Rhodocyclales 206389|Rhodocyclales O COG4235 Cytochrome c biogenesis factor - - - ko:K02200 - - - - ko00000 - - - TPR_16 k59_207916_2 566466.NOR53_546 4.57e-83 248.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1JB6E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_927228_1 744979.R2A130_3028 7.2e-120 350.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E threonine dehydratase tdcB - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_109821_1 1168034.FH5T_08010 2.48e-115 353.0 COG1629@1|root,COG4771@2|Bacteria,4NE4M@976|Bacteroidetes,2FNUY@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_894369_1 1380384.JADN01000006_gene2512 1.88e-116 347.0 COG0635@1|root,COG0635@2|Bacteria,4NEY5@976|Bacteroidetes,1HYDQ@117743|Flavobacteriia 976|Bacteroidetes H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN - - - - - - - - - - - HemN_C,Radical_SAM k59_535736_1 768671.ThimaDRAFT_4174 2.98e-25 101.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1WY34@135613|Chromatiales 135613|Chromatiales S pfam ammecr1 - - - ko:K09141 - - - - ko00000 - - - AMMECR1 k59_535736_2 530564.Psta_0571 4.43e-18 80.5 2E7HP@1|root,33206@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1475) - - - - - - - - - - - - DUF1475 k59_698214_1 589865.DaAHT2_2634 5.24e-34 134.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1MU2H@1224|Proteobacteria,43D5V@68525|delta/epsilon subdivisions,2X8CM@28221|Deltaproteobacteria,2MPN0@213118|Desulfobacterales 1224|Proteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - FeS,Fer2_4,Fer4,Fer4_20,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,Pyr_redox_2 k59_339949_1 1121918.ARWE01000001_gene3366 1.55e-115 362.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,43U3A@69541|Desulfuromonadales 28221|Deltaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding k59_606030_2 1354303.M917_0590 6.72e-41 152.0 COG4984@1|root,COG4984@2|Bacteria,1RB7Y@1224|Proteobacteria,1S046@1236|Gammaproteobacteria,3NSW1@468|Moraxellaceae 1236|Gammaproteobacteria S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157,DUF4401 k59_734939_1 1408473.JHXO01000011_gene3195 2.92e-33 124.0 COG0639@1|root,COG0639@2|Bacteria,4NIDG@976|Bacteroidetes,2FWN0@200643|Bacteroidia 976|Bacteroidetes T Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_734939_2 1408473.JHXO01000012_gene383 6.3e-22 95.5 COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,2FNXT@200643|Bacteroidia 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1029505_1 526218.Sterm_2718 2.4e-291 815.0 COG1882@1|root,COG1882@2|Bacteria,378S4@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score 9.97 pflB - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_1029505_2 1449050.JNLE01000005_gene4050 1.69e-12 65.5 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia,36EN2@31979|Clostridiaceae 186801|Clostridia C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_671616_1 1265313.HRUBRA_02382 1.34e-46 155.0 COG1226@1|root,32YV7@2|Bacteria,1N7MV@1224|Proteobacteria,1S4NR@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1226 Kef-type K transport systems - - - - - - - - - - - - Ion_trans_2 k59_572912_1 98439.AJLL01000070_gene1417 8.87e-66 208.0 COG1051@1|root,COG1051@2|Bacteria,1G4H7@1117|Cyanobacteria,1JH32@1189|Stigonemataceae 1117|Cyanobacteria F Hydrolase of X-linked nucleoside diphosphate N terminal - - - - - - - - - - - - NUDIX,Nudix_N k59_734942_1 1121012.AUKX01000064_gene1065 4.65e-96 296.0 COG5421@1|root,COG5421@2|Bacteria,4PAGJ@976|Bacteroidetes,1IAIH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DDE_Tnp_1 k59_310229_1 309799.DICTH_1450 5.99e-20 87.0 COG0071@1|root,COG0071@2|Bacteria 2|Bacteria O Belongs to the small heat shock protein (HSP20) family MA20_45160 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_11683_1 326298.Suden_1579 4.48e-94 277.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2YN9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S acetyltransferase - - - - - - - - - - - - Hexapep,Hexapep_2 k59_310235_1 1049564.TevJSym_cb00050 1.3e-49 176.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_213901_1 666685.R2APBS1_0400 4.38e-08 55.1 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1X40P@135614|Xanthomonadales 135614|Xanthomonadales M murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_213901_2 243233.MCA0105 3.96e-88 273.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1XE3C@135618|Methylococcales 135618|Methylococcales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_606050_1 641524.ADICYQ_1464 3.06e-15 77.0 COG0330@1|root,COG0330@2|Bacteria,4NHUE@976|Bacteroidetes,47K05@768503|Cytophagia 976|Bacteroidetes O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_671628_1 1121007.AUML01000026_gene1804 6.39e-63 204.0 COG1078@1|root,COG1078@2|Bacteria,4NE1T@976|Bacteroidetes,1HXQF@117743|Flavobacteriia,2YIB6@290174|Aquimarina 976|Bacteroidetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD k59_181435_1 749222.Nitsa_1400 1.47e-44 145.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,42U0I@68525|delta/epsilon subdivisions 1224|Proteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_310244_1 207559.Dde_1185 1.79e-100 308.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42N16@68525|delta/epsilon subdivisions,2X73Y@28221|Deltaproteobacteria,2MBUH@213115|Desulfovibrionales 28221|Deltaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle dppA - - ko:K02035,ko:K12368 ko02010,ko02024,ko02030,map02010,map02024,map02030 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_11705_1 1527515.A0A088F8A6_9CAUD 7.29e-12 67.0 4QC5Z@10239|Viruses,4QPGX@28883|Caudovirales,4QKMB@10699|Siphoviridae 10699|Siphoviridae S Phage Mu protein F like protein - GO:0005575,GO:0019012,GO:0019028,GO:0044423,GO:0046729 - - - - - - - - - - - k59_1029528_1 1172190.M947_09085 3.72e-67 217.0 COG1729@1|root,COG1729@2|Bacteria,1NG81@1224|Proteobacteria,42R1Z@68525|delta/epsilon subdivisions,2YNY7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S repeat protein ybgF - - - - - - - - - - - TPR_16,TPR_2,TPR_6 k59_376572_1 391615.ABSJ01000038_gene382 7.14e-61 209.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1J526@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_148807_1 1537917.JU82_05750 5.99e-177 501.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2YM9G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_376578_1 1122135.KB893151_gene3113 4.73e-45 163.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2U0EN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_998056_1 187272.Mlg_1338 1.02e-94 291.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_572949_1 1288826.MSNKSG1_05466 1.1e-09 62.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,466GX@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_82169_1 713586.KB900536_gene289 6.77e-52 185.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales 135613|Chromatiales V ABC-type transport system, involved in lipoprotein release, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_734976_1 694427.Palpr_1681 4.54e-168 476.0 COG0119@1|root,COG0119@2|Bacteria,4NHR2@976|Bacteroidetes,2FRGF@200643|Bacteroidia,22YPQ@171551|Porphyromonadaceae 976|Bacteroidetes E HMGL-like - - 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 - - - DmpG_comm,HMGL-like k59_181453_2 879212.DespoDRAFT_02234 5.49e-73 229.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RJT0@1224|Proteobacteria,43CRQ@68525|delta/epsilon subdivisions,2X7ZB@28221|Deltaproteobacteria,2MPB2@213118|Desulfobacterales 28221|Deltaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_82176_1 2340.JV46_02800 1.04e-74 236.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1J4I4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_834011_1 991905.SL003B_2904 9.86e-15 73.6 COG1275@1|root,COG1275@2|Bacteria,1MVPG@1224|Proteobacteria,2U072@28211|Alphaproteobacteria,4BSFS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Voltage-dependent anion channel tehA - - ko:K03304 - - - - ko00000,ko02000 2.A.16.1 - - SLAC1 k59_866212_1 1168034.FH5T_09465 4.82e-62 197.0 COG0284@1|root,COG0284@2|Bacteria,4NE12@976|Bacteroidetes,2FPJM@200643|Bacteroidia 976|Bacteroidetes F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_768581_1 1502852.FG94_02150 6.14e-77 233.0 COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2VQDH@28216|Betaproteobacteria,4736X@75682|Oxalobacteraceae 28216|Betaproteobacteria O Redoxin ahp1 - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Redoxin k59_638518_1 439235.Dalk_3587 1.58e-120 368.0 2EWZ3@1|root,33QAE@2|Bacteria,1NR62@1224|Proteobacteria,42YVF@68525|delta/epsilon subdivisions,2WTRF@28221|Deltaproteobacteria,2MMZH@213118|Desulfobacterales 439235.Dalk_3587|- - - - - - - - - - - - - - - - k59_932716_1 387093.SUN_1562 4.48e-79 244.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2YMSY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Co-chaperone-curved DNA binding protein A cbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_932717_1 1249480.B649_11230 2e-18 80.1 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,42MV8@68525|delta/epsilon subdivisions,2YMAE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_932717_2 1244531.CIG1485E_0171 6.05e-31 113.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42U8Y@68525|delta/epsilon subdivisions,2YQ22@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_932717_3 1123326.JFBL01000011_gene188 1.38e-67 207.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2YMUT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_82899_12 396588.Tgr7_2236 4.19e-63 199.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1WW8M@135613|Chromatiales 135613|Chromatiales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_82899_13 1049564.TevJSym_be00080 1.7e-141 403.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1J4EE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - - - - - - - - - - Transcrip_reg k59_82899_14 1300345.LF41_355 7.69e-42 148.0 COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1SAMR@1236|Gammaproteobacteria,1X6RA@135614|Xanthomonadales 135614|Xanthomonadales S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6,Abhydrolase_8 k59_82899_15 1347392.CCEZ01000016_gene2883 1.12e-07 62.4 COG1639@1|root,COG1639@2|Bacteria,1TPRT@1239|Firmicutes,249CG@186801|Clostridia,36FX7@31979|Clostridiaceae 186801|Clostridia T PFAM metal-dependent phosphohydrolase HD sub domain - - - - - - - - - - - - HDOD,Response_reg k59_82899_16 1049564.TevJSym_be00060 1.01e-83 253.0 COG0535@1|root,COG0535@2|Bacteria,1QUQ6@1224|Proteobacteria,1T20T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_14,Radical_SAM k59_82899_17 1147.D082_01410 1.41e-14 73.9 COG1917@1|root,COG1917@2|Bacteria,1G9FM@1117|Cyanobacteria,1H6DY@1142|Synechocystis 1117|Cyanobacteria S Cupin domain - - - - - - - - - - - - Cupin_2 k59_82899_18 765911.Thivi_1025 3.57e-79 243.0 COG1977@1|root,COG3536@1|root,COG1977@2|Bacteria,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1TKAA@1236|Gammaproteobacteria,1X136@135613|Chromatiales 135613|Chromatiales H Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971,ThiS k59_82899_19 765912.Thimo_2322 9.03e-37 130.0 COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,1WYQZ@135613|Chromatiales 135613|Chromatiales S pfam rdd - - - - - - - - - - - - RDD k59_82899_20 1049564.TevJSym_ab01870 2.32e-115 345.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1J4SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Permease lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_82899_21 1049564.TevJSym_ab01860 6.65e-85 269.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1J4YI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Predicted permease YjgP/YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_82899_22 765913.ThidrDRAFT_3644 4.45e-209 595.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1WW8I@135613|Chromatiales 135613|Chromatiales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_82899_23 1049564.TevJSym_ab01840 1.73e-57 182.0 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1J6Y3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG2927 DNA polymerase III, chi subunit holC GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_82899_26 74546.PMT9312_1164 3.3e-79 243.0 COG0438@1|root,COG0438@2|Bacteria,1GGNI@1117|Cyanobacteria 1117|Cyanobacteria H Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_82899_30 1049564.TevJSym_bo00020 2.01e-245 692.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1J4H2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_82899_31 1430440.MGMSRv2_3859 3.11e-86 261.0 COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,2U40G@28211|Alphaproteobacteria,2JT3A@204441|Rhodospirillales 204441|Rhodospirillales C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_82899_32 420662.Mpe_A3500 2.39e-42 142.0 COG3759@1|root,COG3759@2|Bacteria,1MZ4F@1224|Proteobacteria,2VUPP@28216|Betaproteobacteria,1KMDF@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function (DUF1304) - - - ko:K08987 - - - - ko00000 - - - DUF1304 k59_82899_33 357804.Ping_2098 1.14e-123 357.0 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,1RMHT@1236|Gammaproteobacteria,2QIXE@267894|Psychromonadaceae 1236|Gammaproteobacteria M Asp/Glu/Hydantoin racemase ygeA GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_82899_34 396588.Tgr7_3044 1.09e-110 326.0 COG0515@1|root,COG0515@2|Bacteria,1NUIB@1224|Proteobacteria 1224|Proteobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_82899_35 189753.AXAS01000016_gene1429 6.71e-17 93.2 COG4625@1|root,COG4625@2|Bacteria,1PJ2X@1224|Proteobacteria,2U057@28211|Alphaproteobacteria,3JTWR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria U Autotransporter beta-domain - - - - - - - - - - - - Autotransporter k59_82899_36 713586.KB900536_gene463 3.11e-58 182.0 COG3791@1|root,COG3791@2|Bacteria,1PY7G@1224|Proteobacteria,1SXYP@1236|Gammaproteobacteria,1X1WI@135613|Chromatiales 135613|Chromatiales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_82899_37 1049564.TevJSym_an00350 4.37e-166 469.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1J4E7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735 SAICAR_synt k59_82899_38 1144319.PMI16_02718 7.11e-139 403.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4730X@75682|Oxalobacteraceae 28216|Betaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_82899_39 1150469.RSPPHO_02321 7.22e-09 54.3 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2UFC1@28211|Alphaproteobacteria,2JU9A@204441|Rhodospirillales 204441|Rhodospirillales P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_82899_41 926569.ANT_11600 1.13e-169 480.0 COG0191@1|root,COG0191@2|Bacteria 2|Bacteria G fructose-bisphosphate aldolase activity fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_4960 F_bP_aldolase k59_82899_43 519989.ECTPHS_09702 6.75e-199 560.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1WX6Z@135613|Chromatiales 135613|Chromatiales F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_82899_44 999541.bgla_1g05730 1.46e-152 438.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,1K1MS@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap GO:0000166,GO:0000226,GO:0001817,GO:0001819,GO:0001906,GO:0001907,GO:0002376,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0004365,GO:0004857,GO:0004866,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006417,GO:0006464,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007010,GO:0007017,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009620,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010033,GO:0010466,GO:0010468,GO:0010506,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016241,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016769,GO:0016903,GO:0017014,GO:0017144,GO:0017148,GO:0018119,GO:0018130,GO:0018193,GO:0018198,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019730,GO:0019752,GO:0019828,GO:0019904,GO:0030162,GO:0030234,GO:0030414,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031341,GO:0031343,GO:0031640,GO:0031647,GO:0031965,GO:0031967,GO:0031975,GO:0032268,GO:0032269,GO:0032787,GO:0032879,GO:0032880,GO:0032991,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035605,GO:0035606,GO:0035821,GO:0036094,GO:0036211,GO:0042221,GO:0042802,GO:0042866,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043086,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043436,GO:0043891,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0045087,GO:0045861,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050662,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050790,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051287,GO:0051336,GO:0051346,GO:0051402,GO:0051701,GO:0051702,GO:0051704,GO:0051707,GO:0051709,GO:0051712,GO:0051716,GO:0051817,GO:0051818,GO:0051851,GO:0051852,GO:0051873,GO:0051883,GO:0052040,GO:0052042,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0061134,GO:0061135,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0061844,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070887,GO:0070997,GO:0071310,GO:0071345,GO:0071346,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097159,GO:0097452,GO:0097718,GO:0098542,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:1990904,GO:2000112,GO:2000113 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_82899_45 1049564.TevJSym_an00410 0.0 1038.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1J4RR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990 Transket_pyr,Transketolase_C,Transketolase_N k59_82899_46 631362.Thi970DRAFT_01620 4.3e-106 308.0 COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1WWWB@135613|Chromatiales 135613|Chromatiales O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_82899_47 243233.MCA0139 4.68e-216 603.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1XEHS@135618|Methylococcales 135618|Methylococcales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_82899_48 1286093.C266_09092 5.27e-271 749.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,1K11D@119060|Burkholderiaceae 28216|Betaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_82899_49 1249627.D779_1388 5.07e-142 408.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1WW0T@135613|Chromatiales 135613|Chromatiales E PFAM Methylenetetrahydrofolate reductase - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_82899_50 1123355.JHYO01000027_gene2045 1.22e-208 604.0 COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,36XJA@31993|Methylocystaceae 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9 k59_82899_51 1123355.JHYO01000027_gene2046 2.98e-108 323.0 COG3221@1|root,COG3221@2|Bacteria,1PHDV@1224|Proteobacteria,2V91K@28211|Alphaproteobacteria,36Z3R@31993|Methylocystaceae 28211|Alphaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - - - - - - - - - - Phosphonate-bd k59_82899_53 1229276.DI53_1421 0.000355 49.3 COG0705@1|root,COG0705@2|Bacteria,4NECA@976|Bacteroidetes,1IS27@117747|Sphingobacteriia 976|Bacteroidetes S Rhomboid family - - - - - - - - - - - - Rhomboid k59_82899_54 395494.Galf_1572 6.55e-173 493.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_82899_55 1049564.TevJSym_bq00030 3.1e-74 240.0 COG1385@1|root,COG4660@1|root,COG1385@2|Bacteria,COG4660@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1J5UQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_82899_57 713586.KB900536_gene1690 0.0 1029.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_82899_58 95619.PM1_0226545 6.25e-142 437.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_82899_59 161156.JQKW01000006_gene1215 2.37e-08 60.8 COG0835@1|root,COG0835@2|Bacteria,2GIK5@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria NT Two component signalling adaptor domain - - - - - - - - - - - - CheW k59_82899_60 765913.ThidrDRAFT_2085 4.05e-49 161.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria,1WYJQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_82899_61 1288826.MSNKSG1_13537 1.04e-69 212.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,466ZB@72275|Alteromonadaceae 1236|Gammaproteobacteria KT COG0784 FOG CheY-like receiver pilG - - ko:K02657,ko:K03413 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_82899_62 1049564.TevJSym_bn00070 3.64e-149 428.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1J4CV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_871395_1 985665.HPL003_04410 1.06e-51 174.0 COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H9X8@91061|Bacilli,26S8W@186822|Paenibacillaceae 91061|Bacilli E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_281922_2 1033802.SSPSH_002508 4.01e-117 343.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran k59_381797_1 69279.BG36_16850 3.56e-07 52.8 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria,43HIJ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria U UPF0056 membrane protein marC - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_381797_2 314278.NB231_10368 2.51e-19 83.2 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_381797_3 190650.CC_2530 2.99e-19 81.6 COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2UFDN@28211|Alphaproteobacteria,2KJUD@204458|Caulobacterales 204458|Caulobacterales P PFAM Rieske 2Fe-2S iron-sulphur domain - - - - - - - - - - - - Rieske k59_643772_2 1123399.AQVE01000035_gene3176 9.79e-179 510.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_1034583_1 933262.AXAM01000001_gene336 1.61e-65 217.0 COG1960@1|root,COG1960@2|Bacteria,1NU73@1224|Proteobacteria,42Z96@68525|delta/epsilon subdivisions,2WTTK@28221|Deltaproteobacteria,2MN2J@213118|Desulfobacterales 28221|Deltaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_413968_1 314285.KT71_00430 2.71e-94 284.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,1SMBI@1236|Gammaproteobacteria,1J4KN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EP Oligopeptide/dipeptide transporter, C-terminal region dppD - - ko:K02031,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_514148_1 385682.AFSL01000012_gene2824 6.84e-115 338.0 COG4864@1|root,COG4864@2|Bacteria,4NGG6@976|Bacteroidetes,2FPNC@200643|Bacteroidia,3XJ1D@558415|Marinilabiliaceae 976|Bacteroidetes S SigmaW regulon antibacterial - - - - - - - - - - - - YdfA_immunity k59_803164_1 933262.AXAM01000100_gene3391 1.17e-90 289.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MHSK@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_219147_1 497321.C664_08518 7.17e-16 77.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,2KUWG@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_219147_2 335283.Neut_2430 1.52e-33 125.0 COG3247@1|root,COG3247@2|Bacteria,1RH69@1224|Proteobacteria,2VUMS@28216|Betaproteobacteria,374BN@32003|Nitrosomonadales 28216|Betaproteobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_219147_3 1210045.ALNP01000032_gene2591 9.07e-10 58.5 COG3573@1|root,COG3573@2|Bacteria,2GIYM@201174|Actinobacteria 201174|Actinobacteria S Dehydrogenase - - - ko:K07077 - - - - ko00000 - - - FAD_binding_2 k59_52860_1 1121937.AUHJ01000001_gene660 6.68e-49 177.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,465F9@72275|Alteromonadaceae 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_708702_1 314345.SPV1_01472 1.4e-57 194.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria 1224|Proteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 ko:K02495 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R06895 RC00884 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403 HemN_C,Radical_SAM k59_937940_1 522772.Dacet_0794 1.43e-27 107.0 2DPYP@1|root,333ZP@2|Bacteria,2GGDZ@200930|Deferribacteres 200930|Deferribacteres C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 k59_281937_1 933262.AXAM01000001_gene334 1.79e-82 267.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MIJD@213118|Desulfobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_17196_1 1168065.DOK_03203 0.000699 45.1 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RS91@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_644545_1 1144313.PMI10_01121 1.05e-88 286.0 COG4677@1|root,COG4677@2|Bacteria,4NEEI@976|Bacteroidetes,1IK65@117743|Flavobacteriia,2NTRG@237|Flavobacterium 976|Bacteroidetes G Pectinesterase - - - - - - - - - - - - Pectinesterase k59_219849_2 1123354.AUDR01000020_gene1982 6.1e-12 63.9 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2VQUQ@28216|Betaproteobacteria,1KSDR@119069|Hydrogenophilales 119069|Hydrogenophilales D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf k59_677768_1 342113.DM82_4718 1.01e-90 287.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJTV@28216|Betaproteobacteria,1K4JX@119060|Burkholderiaceae 28216|Betaproteobacteria M outer_NodT efflux transporter, outer membrane factor (OMF) lipo, NodT family protein - - - - - - - - - - - - OEP k59_514816_1 419665.Maeo_0394 1.63e-25 107.0 COG0438@1|root,arCOG01411@2157|Archaea,2XW22@28890|Euryarchaeota 28890|Euryarchaeota M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_121306_1 1298865.H978DRAFT_0392 3.09e-31 127.0 COG2911@1|root,COG3210@1|root,COG3291@1|root,COG4932@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,465B9@72275|Alteromonadaceae 1236|Gammaproteobacteria M Bacterial Ig-like domain (group 3) - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3 k59_970875_1 105559.Nwat_0763 2.43e-97 300.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1WXRW@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_546506_1 1121405.dsmv_1729 1.18e-55 185.0 COG2177@1|root,COG2177@2|Bacteria,1R85B@1224|Proteobacteria,42PXG@68525|delta/epsilon subdivisions,2WKX3@28221|Deltaproteobacteria,2MIBU@213118|Desulfobacterales 28221|Deltaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_546506_2 335541.Swol_0126 4.65e-06 53.1 COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,COG4991@2|Bacteria,1UYPW@1239|Firmicutes,24BHU@186801|Clostridia,42K1M@68298|Syntrophomonadaceae 186801|Clostridia M Ami_3 lytC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,Cu_amine_oxidN1 k59_644571_1 944547.ABLL_2045 2.69e-10 68.9 COG1357@1|root,COG1357@2|Bacteria,1NCWB@1224|Proteobacteria,42WFQ@68525|delta/epsilon subdivisions,2YQN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Pentapeptide repeats (8 copies) - - - - - - - - - - - - Pentapeptide_3 k59_514830_1 572480.Arnit_2574 1.16e-82 256.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2YMID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_774631_1 1218173.BALCAV_0200810 2.28e-41 147.0 COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,4HANU@91061|Bacilli,1ZB76@1386|Bacillus 91061|Bacilli G Belongs to the carbohydrate kinase PfkB family pfkB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 2.7.1.56 ko:K00882 ko00051,map00051 - R02071 RC00002,RC00017 ko00000,ko00001,ko01000 - - iYO844.BSU14390 PfkB k59_774631_2 1423321.AS29_13655 6.57e-43 149.0 COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,4HDT9@91061|Bacilli,1ZBIR@1386|Bacillus 91061|Bacilli K Transcriptional regulator fruR - - ko:K03436 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR k59_1004096_1 1168034.FH5T_16750 1.35e-42 141.0 COG1366@1|root,COG1366@2|Bacteria,4NTAB@976|Bacteroidetes,2FYPE@200643|Bacteroidia 976|Bacteroidetes T STAS domain - - - - - - - - - - - - STAS,STAS_2 k59_1004096_2 1168034.FH5T_16755 0.0 898.0 COG0539@1|root,COG0539@2|Bacteria,4NDW9@976|Bacteroidetes,2FNZK@200643|Bacteroidia 976|Bacteroidetes J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_546533_1 1121875.KB907559_gene532 2.75e-42 150.0 COG0596@1|root,COG0596@2|Bacteria,4NPF5@976|Bacteroidetes,1I254@117743|Flavobacteriia 976|Bacteroidetes S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 k59_316216_2 573413.Spirs_0891 8.16e-95 291.0 COG1609@1|root,COG1609@2|Bacteria 2|Bacteria K purine nucleotide biosynthetic process - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_938567_1 396588.Tgr7_1777 2.04e-99 293.0 COG5340@1|root,COG5340@2|Bacteria,1PFSA@1224|Proteobacteria,1SJHP@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_938567_2 338963.Pcar_0281 1.6e-150 432.0 COG2253@1|root,COG2253@2|Bacteria,1PZRM@1224|Proteobacteria,42SAJ@68525|delta/epsilon subdivisions,2X5C7@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_938567_4 395494.Galf_2039 1.19e-34 121.0 COG3093@1|root,COG3093@2|Bacteria,1PSY1@1224|Proteobacteria,2WAF3@28216|Betaproteobacteria,44WMR@713636|Nitrosomonadales 28216|Betaproteobacteria K TIGRFAM addiction module antidote protein, HigA family - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_938567_5 395494.Galf_2287 7.98e-113 340.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VI1Z@28216|Betaproteobacteria,44W9U@713636|Nitrosomonadales 28216|Betaproteobacteria C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_938567_6 517418.Ctha_0894 1.88e-55 206.0 COG4191@1|root,COG4191@2|Bacteria,1FF4U@1090|Chlorobi 2|Bacteria T PFAM ATP-binding region, ATPase domain protein - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - AA_permease_2,Ammonium_transp,CBS,CHASE2,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,dCache_1 k59_938567_7 1122604.JONR01000004_gene763 2.37e-59 201.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,1S1WE@1236|Gammaproteobacteria,1X9QR@135614|Xanthomonadales 135614|Xanthomonadales KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_938567_9 856793.MICA_221 6.3e-33 127.0 COG2353@1|root,COG3038@1|root,COG2353@2|Bacteria,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria,4BQQ1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Prokaryotic cytochrome b561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB,YceI k59_938567_13 1005048.CFU_1187 3.1e-103 309.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria,473K3@75682|Oxalobacteraceae 28216|Betaproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_938567_14 426114.THI_3126 2.59e-108 337.0 COG0642@1|root,COG0642@2|Bacteria,1PA1G@1224|Proteobacteria,2VHX5@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - HAMP,HATPase_c,HisKA k59_938567_17 1265505.ATUG01000003_gene627 4.42e-31 114.0 2E8UW@1|root,3335A@2|Bacteria,1N8I8@1224|Proteobacteria,42TGA@68525|delta/epsilon subdivisions,2WQAG@28221|Deltaproteobacteria,2MKHK@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_938567_18 314231.FP2506_16114 0.000279 48.9 COG0810@1|root,COG0810@2|Bacteria,1PF2W@1224|Proteobacteria,2VAPM@28211|Alphaproteobacteria,2PK7J@255475|Aurantimonadaceae 28211|Alphaproteobacteria M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_938567_19 2340.JV46_08360 2.55e-41 140.0 COG0848@1|root,COG0848@2|Bacteria,1PQKY@1224|Proteobacteria,1SG1V@1236|Gammaproteobacteria 1236|Gammaproteobacteria U biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_938567_20 2340.JV46_08350 2.62e-92 276.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1S2ZN@1236|Gammaproteobacteria,1J733@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U MotA/TolQ/ExbB proton channel family exbB2 - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_938567_21 2340.JV46_08400 1.19e-235 677.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria,1J5AV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor oprC - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_938567_22 1172190.M947_00055 6.1e-237 684.0 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,42PHJ@68525|delta/epsilon subdivisions,2YNKV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_938567_23 1049564.TevJSym_be00330 2.64e-19 87.8 COG3134@1|root,COG3134@2|Bacteria,1MVWD@1224|Proteobacteria,1RQR9@1236|Gammaproteobacteria,1J6IN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S outer membrane lipoprotein - - - - - - - - - - - - Rick_17kDa_Anti k59_938567_24 1123073.KB899241_gene2710 5.85e-06 48.1 2A9QK@1|root,30YXS@2|Bacteria,1QBJS@1224|Proteobacteria,1T75C@1236|Gammaproteobacteria,1X8T5@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_938567_25 1500893.JQNB01000001_gene1518 6.43e-111 324.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1X2XT@135614|Xanthomonadales 135614|Xanthomonadales KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_938567_26 1283300.ATXB01000002_gene3009 5.07e-117 357.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,1XE88@135618|Methylococcales 135618|Methylococcales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_938567_27 1249627.D779_2831 3.54e-127 374.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1WW4C@135613|Chromatiales 135613|Chromatiales S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_938567_28 1116472.MGMO_8c00980 5.63e-157 456.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,1XE2Z@135618|Methylococcales 135618|Methylococcales O Peptidase, M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_938567_29 2340.JV46_15240 1.5e-90 270.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1J5R2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria A 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_872277_1 1168034.FH5T_18935 4.04e-120 362.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE71@976|Bacteroidetes,2FQB7@200643|Bacteroidia 976|Bacteroidetes C dehydrogenase E1 component bfmBAB - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_154887_1 1487953.JMKF01000020_gene2253 5.08e-54 173.0 COG4101@1|root,COG4101@2|Bacteria,1G64Q@1117|Cyanobacteria,1HFQH@1150|Oscillatoriales 1117|Cyanobacteria G Cupin - - - - - - - - - - - - Cupin_2 k59_382485_2 247490.KSU1_C1444 5.48e-63 209.0 COG0523@1|root,COG0523@2|Bacteria,2IXBH@203682|Planctomycetes 203682|Planctomycetes S PFAM cobalamin synthesis protein - - - - - - - - - - - - CobW_C,cobW k59_905653_1 1218074.BAXZ01000040_gene5387 3.57e-17 85.5 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VHCI@28216|Betaproteobacteria,1K0IC@119060|Burkholderiaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_970918_1 13035.Dacsa_1498 1.21e-66 213.0 COG0667@1|root,COG0667@2|Bacteria,1G1J4@1117|Cyanobacteria 1117|Cyanobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_774645_2 177437.HRM2_p00170 6.82e-107 315.0 COG1484@1|root,COG1484@2|Bacteria,1MZVC@1224|Proteobacteria,430QU@68525|delta/epsilon subdivisions,2WW1K@28221|Deltaproteobacteria,2MNR3@213118|Desulfobacterales 28221|Deltaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_53687_1 1168034.FH5T_17505 3.08e-97 309.0 COG0419@1|root,COG0419@2|Bacteria,4PN9E@976|Bacteroidetes 976|Bacteroidetes L oxidoreductase activity - - - - - - - - - - - - - k59_316233_1 1123401.JHYQ01000007_gene542 1.04e-94 302.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales 72273|Thiotrichales C Molybdopterin oxidoreductase Fe4S4 domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_840079_1 1163617.SCD_n00016 9.94e-74 227.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria 28216|Betaproteobacteria NU NYN domain - - - - - - - - - - - - NYN,OST-HTH k59_187412_1 1049564.TevJSym_ag00520 6.92e-63 201.0 COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,1S3KS@1236|Gammaproteobacteria,1JBXT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Cobalt uptake substrate-specific transmembrane region - - - - - - - - - - - - CbiM k59_774663_1 938293.CAJU020000016_gene1638 7.28e-05 46.6 COG1680@1|root,COG1680@2|Bacteria,1UUHI@1239|Firmicutes,25MWC@186801|Clostridia,22H8B@1570339|Peptoniphilaceae 186801|Clostridia V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_88442_1 933262.AXAM01000048_gene2579 8.88e-119 350.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2MI44@213118|Desulfobacterales 28221|Deltaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_872321_1 1121472.AQWN01000009_gene439 3.63e-52 175.0 COG2070@1|root,COG2070@2|Bacteria,1VTQJ@1239|Firmicutes,24ZN0@186801|Clostridia,26495@186807|Peptococcaceae 186801|Clostridia S FMN-dependent dehydrogenase - - - - - - - - - - - - NMO k59_187435_1 1189619.pgond44_08757 1.51e-17 85.5 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia,4C4FU@83612|Psychroflexus 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - HTH_18,TPR_8 k59_747637_1 666681.M301_2515 3.23e-07 58.2 COG2984@1|root,COG2984@2|Bacteria,1NACH@1224|Proteobacteria,2VSU8@28216|Betaproteobacteria,2KNUQ@206350|Nitrosomonadales 206350|Nitrosomonadales S ABC transporter substrate binding protein - - - - - - - - - - - - ABC_sub_bind k59_61283_1 1537917.JU82_04110 1.32e-41 152.0 COG2215@1|root,COG2215@2|Bacteria,1MX4D@1224|Proteobacteria,42PHI@68525|delta/epsilon subdivisions,2YM9S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the NiCoT transporter (TC 2.A.52) family - - - - - - - - - - - - DUF1007,NicO k59_554610_2 545693.BMQ_4074 9.97e-13 69.7 COG1988@1|root,COG1988@2|Bacteria,1V3QT@1239|Firmicutes,4HGYG@91061|Bacilli,1ZFRV@1386|Bacillus 91061|Bacilli S LexA-binding, inner membrane-associated putative hydrolase yvsG - - ko:K07038 - - - - ko00000 - - - YdjM k59_946062_1 1122164.JHWF01000010_gene2454 2.06e-31 127.0 COG0160@1|root,COG0160@2|Bacteria,1MX0Y@1224|Proteobacteria,1RQ9Z@1236|Gammaproteobacteria,1JD89@118969|Legionellales 118969|Legionellales H Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 k59_685139_1 1168034.FH5T_08370 2.41e-90 274.0 COG0142@1|root,COG0142@2|Bacteria,4NET2@976|Bacteroidetes,2FMMI@200643|Bacteroidia 976|Bacteroidetes H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_716455_1 563040.Saut_0912 2.57e-64 209.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2YMTB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_716455_2 929558.SMGD1_0149 7.04e-64 213.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2YN0E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the UbiD family menA - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0396 UbiD k59_227153_1 1049564.TevJSym_bc00020 9.83e-70 223.0 COG5361@1|root,COG5361@2|Bacteria,1NBVB@1224|Proteobacteria,1SES6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Neurotransmitter-gated ion-channel ligand binding domain - - - - - - - - - - - - Neur_chan_LBD,Neur_chan_memb k59_486505_2 1122173.AXVL01000005_gene229 1.44e-138 405.0 COG1903@1|root,COG1903@2|Bacteria,378M2@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k59_486505_3 469618.FVAG_02678 7.8e-56 183.0 COG2241@1|root,COG2241@2|Bacteria,3792K@32066|Fusobacteria 32066|Fusobacteria H precorrin-6y C5,15-methyltransferase cbiE - 2.1.1.289 ko:K03399 ko00860,ko01100,map00860,map01100 - R05813,R07775 RC00003,RC02052,RC02053 ko00000,ko00001,ko01000 - - - TP_methylase k59_486505_4 748727.CLJU_c31900 3.86e-49 164.0 COG2242@1|root,COG2242@2|Bacteria,1TS3H@1239|Firmicutes,2483G@186801|Clostridia,36I4B@31979|Clostridiaceae 186801|Clostridia H Precorrin-6Y C5,15-methyltransferase (Decarboxylating), CbiT subunit cbiT - 2.1.1.132,2.1.1.196 ko:K00595,ko:K02191 ko00860,ko01100,map00860,map01100 - R05149,R05813,R07774 RC00003,RC01279,RC02052,RC02054 ko00000,ko00001,ko01000 - - - CbiJ,Cons_hypoth95,MTS,Met_10,Methyltransf_31,Methyltransf_4,PCMT,TP_methylase k59_486505_5 526218.Sterm_1012 8.02e-78 239.0 COG2243@1|root,COG2243@2|Bacteria,378CG@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score cobI - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase k59_586551_1 556263.FSEG_00709 5.79e-18 84.0 COG2256@1|root,COG2256@2|Bacteria,3798D@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_586551_2 572544.Ilyop_0421 3.42e-200 565.0 COG0124@1|root,COG0124@2|Bacteria,378SC@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_586551_3 572544.Ilyop_0422 0.0 942.0 COG0173@1|root,COG0173@2|Bacteria,37982@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA-synt_2d,tRNA_anti-codon k59_586551_4 572544.Ilyop_0423 4.38e-254 709.0 COG0018@1|root,COG0018@2|Bacteria,378C4@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score 9.97 argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_879265_1 595460.RRSWK_06486 2.15e-09 56.6 COG3258@1|root,COG3258@2|Bacteria,2J1GU@203682|Planctomycetes 203682|Planctomycetes C Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_162915_1 765869.BDW_13460 1.01e-14 79.3 2FK00@1|root,34BNB@2|Bacteria,1QSMS@1224|Proteobacteria,43EZQ@68525|delta/epsilon subdivisions,2MTRN@213481|Bdellovibrionales,2WYKK@28221|Deltaproteobacteria 213481|Bdellovibrionales S Domain of unknown function (DUF4423) - - - - - - - - - - - - DUF4423 k59_289917_1 1049564.TevJSym_ap00360 4.87e-98 297.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1J4EQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUTI89_1310.UTI89_C0772,iZ_1308.Z0993 Aminotran_3 k59_747650_1 1235788.C802_01700 4.68e-88 286.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FKYX@200643|Bacteroidia,4AK5Y@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_95414_1 1313421.JHBV01000021_gene4835 2.97e-24 106.0 COG3291@1|root,COG3291@2|Bacteria,4PMDA@976|Bacteroidetes 976|Bacteroidetes O domain protein - - - - - - - - - - - - PKD k59_879276_1 1168034.FH5T_10400 1.87e-102 325.0 COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes,2FM1V@200643|Bacteroidia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_289923_1 1121921.KB898706_gene3352 1.6e-66 210.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,2PN2U@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria D 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_289923_2 1380387.JADM01000004_gene2852 1.44e-42 149.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1XHMA@135619|Oceanospirillales 135619|Oceanospirillales K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_25173_1 765912.Thimo_2103 6.99e-50 167.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1WWXT@135613|Chromatiales 135613|Chromatiales V PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_25173_2 768671.ThimaDRAFT_3374 7.94e-24 97.1 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,1RRH4@1236|Gammaproteobacteria,1X2HQ@135613|Chromatiales 135613|Chromatiales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_391038_1 1165841.SULAR_02583 6.07e-148 433.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,42MQD@68525|delta/epsilon subdivisions,2YNHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0659 Sulfate permease and related - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_455902_1 4558.Sb07g023090.1 0.000228 48.9 2CN5X@1|root,2QU1T@2759|Eukaryota,37T40@33090|Viridiplantae,3GHPU@35493|Streptophyta,3M9JT@4447|Liliopsida,3IKES@38820|Poales 35493|Streptophyta - - - - - - - - - - - - - - DBD_Tnp_Mut,MULE,SWIM k59_25179_1 1123248.KB893348_gene179 1.29e-65 220.0 COG1874@1|root,COG1874@2|Bacteria,4NINF@976|Bacteroidetes,1IRBE@117747|Sphingobacteriia 976|Bacteroidetes G Beta-galactosidase trimerisation domain - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M k59_554648_1 639282.DEFDS_0113 2.28e-13 70.9 COG0162@1|root,COG0162@2|Bacteria,2GENZ@200930|Deferribacteres 200930|Deferribacteres J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_554648_2 935837.JAEK01000011_gene168 7.94e-18 87.0 COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H9SA@91061|Bacilli,1ZAXY@1386|Bacillus 91061|Bacilli M penicillin-binding protein ponA GO:0005575,GO:0005576 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,fn3 k59_651480_1 631362.Thi970DRAFT_04901 5.21e-124 358.0 COG1122@1|root,COG1122@2|Bacteria,1N5X0@1224|Proteobacteria,1RRHF@1236|Gammaproteobacteria,1X2C6@135613|Chromatiales 135613|Chromatiales P ABC transporter - - - ko:K02006 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - ABC_tran k59_391044_1 1042163.BRLA_c045290 4.57e-09 59.3 COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,4ISAE@91061|Bacilli,26T5P@186822|Paenibacillaceae 91061|Bacilli C Reduces fumarate to succinate in anaerobic bacterial respiration - - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,FMN_bind,FMN_red,Succ_DH_flav_C k59_522555_1 526226.Gbro_4767 1.51e-66 214.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4GCQ9@85026|Gordoniaceae 201174|Actinobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_28,HTH_32 k59_716522_1 1535422.ND16A_1041 2.14e-61 207.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oligopeptide transporter oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT k59_716522_2 1254432.SCE1572_14255 7.98e-54 182.0 COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,42N8Z@68525|delta/epsilon subdivisions,2WTR2@28221|Deltaproteobacteria,2YU56@29|Myxococcales 28221|Deltaproteobacteria H AbgT putative transporter family abgT - - ko:K12942 - - - - ko00000 - - - ABG_transport k59_289944_1 1049564.TevJSym_bg00290 1.36e-107 315.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1J7ZN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S CbbQ/NirQ/NorQ C-terminal nirQ - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_194958_1 1144275.COCOR_01193 8.96e-17 89.4 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2YU1G@29|Myxococcales 28221|Deltaproteobacteria F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_421422_1 768671.ThimaDRAFT_2764 4.77e-70 219.0 COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,1S3FR@1236|Gammaproteobacteria,1X02B@135613|Chromatiales 135613|Chromatiales E PFAM N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_554686_2 1121918.ARWE01000001_gene3341 3.94e-15 72.0 COG1595@1|root,COG1595@2|Bacteria,1Q4ZI@1224|Proteobacteria,42TYH@68525|delta/epsilon subdivisions,2WQNG@28221|Deltaproteobacteria,43UPJ@69541|Desulfuromonadales 28221|Deltaproteobacteria K Sigma-70, region 4 carQ - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_128488_1 768670.Calni_1765 2.47e-07 58.9 COG0348@1|root,COG1143@1|root,COG1245@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1245@2|Bacteria,2GGCX@200930|Deferribacteres 200930|Deferribacteres C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5 k59_946130_1 1331660.L313_2391 8.12e-66 223.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,3NJZQ@468|Moraxellaceae 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_25213_1 335543.Sfum_2752 2.05e-91 278.0 COG0310@1|root,COG0310@2|Bacteria,1PK7N@1224|Proteobacteria,43E7G@68525|delta/epsilon subdivisions,2X22W@28221|Deltaproteobacteria,2MSEF@213462|Syntrophobacterales 28221|Deltaproteobacteria P Cobalt uptake substrate-specific transmembrane region - - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_289948_2 1123326.JFBL01000015_gene2411 3.68e-26 103.0 COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2YP2C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator nssR - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_162983_1 1168034.FH5T_10945 1.53e-207 593.0 COG0855@1|root,COG0855@2|Bacteria,4NE3P@976|Bacteroidetes,2FM68@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_619503_1 1344012.ATMI01000025_gene84 3.32e-07 51.2 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,4BUTW@82986|Tatumella 1236|Gammaproteobacteria M MacB-like periplasmic core domain lolC GO:0005575,GO:0005623,GO:0005886,GO:0008104,GO:0008150,GO:0016020,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_619503_2 1123261.AXDW01000001_gene1445 9.19e-95 285.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales 135614|Xanthomonadales V Part of the ABC transporter complex LolCDE involved in the translocation of lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_486573_1 933262.AXAM01000014_gene274 3.09e-10 58.2 COG0135@1|root,COG0135@2|Bacteria,1RFH8@1224|Proteobacteria,42RT5@68525|delta/epsilon subdivisions,2WNTK@28221|Deltaproteobacteria,2MK21@213118|Desulfobacterales 28221|Deltaproteobacteria E N-(5'phosphoribosyl)anthranilate (PRA) isomerase - - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_486573_2 1121405.dsmv_0032 4.88e-92 272.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2WNG7@28221|Deltaproteobacteria,2MHWW@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_195715_2 1415780.JPOG01000001_gene3049 0.0003 43.9 COG1487@1|root,COG1487@2|Bacteria,1RHIX@1224|Proteobacteria,1S6AM@1236|Gammaproteobacteria,1X899@135614|Xanthomonadales 135614|Xanthomonadales S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - - - - - - - - - - PIN k59_290566_1 1168034.FH5T_10355 2.29e-124 364.0 COG1168@1|root,COG1168@2|Bacteria,4NETH@976|Bacteroidetes,2FMIZ@200643|Bacteroidia 976|Bacteroidetes E Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_61866_1 550540.Fbal_0192 1.33e-09 60.8 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_61866_2 675812.VHA_000545 2.53e-27 108.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1XUYC@135623|Vibrionales 135623|Vibrionales O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_391721_1 335283.Neut_2425 7.65e-170 509.0 COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,2VKQ5@28216|Betaproteobacteria,371RS@32003|Nitrosomonadales 28216|Betaproteobacteria L Putative exonuclease SbcCD, C subunit sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SbcCD_C k59_129339_1 557598.LHK_01010 7.98e-20 95.5 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,2KPTZ@206351|Neisseriales 206351|Neisseriales T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_195719_1 1172190.M947_02010 3.09e-66 204.0 COG1416@1|root,COG1416@2|Bacteria,1NI85@1224|Proteobacteria,42TA0@68525|delta/epsilon subdivisions,2YPH8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_195719_2 387092.NIS_1826 2.87e-21 90.5 COG2143@1|root,COG2143@2|Bacteria,1NEN3@1224|Proteobacteria,42SXU@68525|delta/epsilon subdivisions,2YPR0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7 k59_391723_1 338969.Rfer_2740 2.08e-81 248.0 COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,2VP9C@28216|Betaproteobacteria 1224|Proteobacteria C cytochrome cbcB - - - - - - - - - - - Ni_hydr_CYTB k59_422093_1 396588.Tgr7_1267 7.58e-203 572.0 COG0247@1|root,COG1145@1|root,COG0247@2|Bacteria,COG1145@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1WWK6@135613|Chromatiales 135613|Chromatiales C PFAM Cysteine-rich - - - - - - - - - - - - CCG,Fer4_8 k59_1011607_1 1121943.KB899997_gene1768 5.47e-93 288.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1XNGN@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_811975_2 1165841.SULAR_04547 4.36e-34 122.0 COG1309@1|root,COG1309@2|Bacteria,1PFK7@1224|Proteobacteria,42UZC@68525|delta/epsilon subdivisions,2YQ5V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K03577 - M00647 - - ko00000,ko00002,ko03000 - - - TetR_N k59_358735_1 471881.PROPEN_02651 5.12e-05 50.8 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,3Z1HT@583|Proteus 1236|Gammaproteobacteria I Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 aas GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008779,GO:0008922,GO:0009058,GO:0009987,GO:0015645,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019752,GO:0031224,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3034 AMP-binding,AMP-binding_C,Acyltransferase k59_717170_1 1123392.AQWL01000002_gene1831 2.51e-35 135.0 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria 28216|Betaproteobacteria S Phospholipase, patatin family - - - ko:K07001 - - - - ko00000 - - - Patatin k59_978568_1 2340.JV46_26360 1.84e-25 104.0 COG3203@1|root,COG3203@2|Bacteria,1RH1J@1224|Proteobacteria,1S06S@1236|Gammaproteobacteria,1J68K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M membrane - - - - - - - - - - - - Porin_4 k59_620134_1 1502770.JQMG01000001_gene159 2.36e-95 297.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,2KKYE@206350|Nitrosomonadales 206350|Nitrosomonadales P transporter of a GTP-driven Fe(2 ) uptake system - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_456547_1 1353528.DT23_15825 3.01e-35 130.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,2XM68@285107|Thioclava 28211|Alphaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_456547_2 1185766.DL1_16280 3.37e-16 79.7 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,2XM7H@285107|Thioclava 28211|Alphaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_290603_1 469618.FVAG_02885 1.38e-82 256.0 COG0707@1|root,COG0707@2|Bacteria,378TW@32066|Fusobacteria 32066|Fusobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_61891_1 502025.Hoch_0856 3.19e-43 157.0 COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42MUS@68525|delta/epsilon subdivisions,2WKK4@28221|Deltaproteobacteria,2YZBQ@29|Myxococcales 28221|Deltaproteobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_685921_1 313594.PI23P_05372 3.82e-23 102.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1HWM8@117743|Flavobacteriia,3VVDP@52959|Polaribacter 976|Bacteroidetes H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 k59_358749_2 573569.F7308_0301 5.51e-160 457.0 COG3654@1|root,COG3943@1|root,COG3654@2|Bacteria,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,1RPNB@1236|Gammaproteobacteria,4606E@72273|Thiotrichales 72273|Thiotrichales S Virulence protein RhuM family - - - - - - - - - - - - Fic,Virulence_RhuM k59_323391_1 331869.BAL199_13463 1.82e-54 183.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,4BPJ8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family fabB GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_293392_1 387093.SUN_1244 8.86e-28 107.0 COG3023@1|root,COG3023@2|Bacteria,1PV6E@1224|Proteobacteria,42ZQH@68525|delta/epsilon subdivisions,2YRNB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2 k59_293392_2 387093.SUN_1245 1.55e-16 79.7 2AIU4@1|root,319B6@2|Bacteria,1Q28N@1224|Proteobacteria,42V6E@68525|delta/epsilon subdivisions,2YQ6D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_751247_1 1121013.P873_12905 5.02e-41 149.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1X3TM@135614|Xanthomonadales 135614|Xanthomonadales H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_293396_1 1223410.KN050846_gene2045 3.74e-87 273.0 COG2957@1|root,COG2957@2|Bacteria,4NGF8@976|Bacteroidetes,1HYT2@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the agmatine deiminase family - - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_814744_1 13333.ERN11805 5.51e-285 838.0 2CMQD@1|root,2QRDV@2759|Eukaryota,37QIN@33090|Viridiplantae,3GEA1@35493|Streptophyta 35493|Streptophyta S function. Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis ycf2 - - - - - - - - - - - AAA,DUF825 k59_489938_1 1415754.JQMK01000002_gene3331 1.63e-47 164.0 COG4221@1|root,COG4221@2|Bacteria,1RAKI@1224|Proteobacteria,1T2GK@1236|Gammaproteobacteria,46AWI@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short k59_64225_1 1121875.KB907550_gene755 3.39e-91 277.0 COG4948@1|root,COG4948@2|Bacteria,4NG8N@976|Bacteroidetes,1HWNA@117743|Flavobacteriia 976|Bacteroidetes M Mandelate racemase muconate lactonizing enzyme - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 4.2.1.113,5.1.1.20 ko:K02549,ko:K19802 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031,R10938 RC01053,RC03309 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_882429_1 1121940.AUDZ01000007_gene2235 1.43e-46 155.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1XHWE@135619|Oceanospirillales 135619|Oceanospirillales H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_882429_2 1049564.TevJSym_as00150 1.93e-203 594.0 COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1JAB5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acid phosphatase homologues lssY - - ko:K03975 - - - - ko00000 - - - LssY_C,PAP2,SNARE_assoc k59_882429_3 261292.Nit79A3_2149 1.62e-17 77.0 COG2841@1|root,COG2841@2|Bacteria,1Q94N@1224|Proteobacteria,2WC7F@28216|Betaproteobacteria,374E8@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF465) - - - ko:K09794 - - - - ko00000 - - - DUF465 k59_882434_1 83406.HDN1F_14510 1.18e-37 141.0 COG2199@1|root,COG3706@2|Bacteria,1QVPW@1224|Proteobacteria,1T2GC@1236|Gammaproteobacteria,1JAKM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_489949_1 323848.Nmul_A1669 4.87e-85 261.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2VH3K@28216|Betaproteobacteria,3733V@32003|Nitrosomonadales 28216|Betaproteobacteria O AIR synthase related protein, N-terminal domain - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_424903_1 1179778.PMM47T1_05594 4.77e-20 94.7 COG2010@1|root,COG2010@2|Bacteria,1MVYK@1224|Proteobacteria,1RQH2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_424903_2 520709.F985_02681 1.94e-84 269.0 COG0753@1|root,COG0753@2|Bacteria,1N4WM@1224|Proteobacteria,1T1QK@1236|Gammaproteobacteria,3NJ16@468|Moraxellaceae 1236|Gammaproteobacteria P Catalase - - - - - - - - - - - - Catalase k59_28408_2 768706.Desor_3002 1.67e-36 137.0 COG0243@1|root,COG0243@2|Bacteria,1VT07@1239|Firmicutes,24Y7B@186801|Clostridia,263YC@186807|Peptococcaceae 186801|Clostridia C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_849822_1 439235.Dalk_5069 1.65e-46 155.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42RCD@68525|delta/epsilon subdivisions,2WMUP@28221|Deltaproteobacteria,2MPV5@213118|Desulfobacterales 28221|Deltaproteobacteria C Thioredoxin-like [2Fe-2S] ferredoxin bamG - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_489998_1 983328.AFGH01000025_gene77 7.03e-29 117.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,42MJA@68525|delta/epsilon subdivisions,2YMX6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0903m Acetate_kinase k59_882475_1 1033810.HLPCO_001933 5.8e-100 319.0 COG2217@1|root,COG2217@2|Bacteria,2NNPJ@2323|unclassified Bacteria 2|Bacteria P E1-E2 ATPase copA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_882475_3 572544.Ilyop_1495 6.02e-38 129.0 COG1937@1|root,COG1937@2|Bacteria,37AWC@32066|Fusobacteria 32066|Fusobacteria S Metal-sensitive transcriptional repressor - - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal k59_882475_4 572544.Ilyop_1761 5.39e-81 246.0 COG2013@1|root,COG2013@2|Bacteria,37B66@32066|Fusobacteria 32066|Fusobacteria S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k59_751327_1 1049564.TevJSym_bt00100 2.58e-21 94.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1S7I9@1236|Gammaproteobacteria,1JBVR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MacB-like periplasmic core domain VPA0559 - - - - - - - - - - - FtsX,MacB_PCD k59_751327_2 452637.Oter_0572 3.35e-19 87.8 COG1136@1|root,COG1136@2|Bacteria,46V8D@74201|Verrucomicrobia 74201|Verrucomicrobia V ATPases associated with a variety of cellular activities - - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_64289_1 1122185.N792_11840 1.19e-53 191.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1X36U@135614|Xanthomonadales 135614|Xanthomonadales CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_293483_2 1123253.AUBD01000008_gene507 5.64e-99 299.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales 135614|Xanthomonadales I Acyl-CoA dehydrogenase gcdH - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_326283_1 323261.Noc_1367 2.61e-189 548.0 COG1743@1|root,COG1743@2|Bacteria,1P7I6@1224|Proteobacteria,1RY2K@1236|Gammaproteobacteria,1WXME@135613|Chromatiales 135613|Chromatiales L DNA methylase - - - - - - - - - - - - HTH_31,N6_N4_Mtase k59_882515_2 411479.BACUNI_00925 1.53e-24 106.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FN3Y@200643|Bacteroidia,4AP89@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_293501_1 765912.Thimo_1933 2.41e-46 169.0 COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,1RMJS@1236|Gammaproteobacteria,1WW9Q@135613|Chromatiales 135613|Chromatiales C belongs to the CobB CobQ family - - 2.3.1.8 ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,DRTGG,PTA_PTB k59_293515_1 1168034.FH5T_14155 8.3e-149 424.0 COG0462@1|root,COG0462@2|Bacteria,4NEVF@976|Bacteroidetes,2FPH1@200643|Bacteroidia 976|Bacteroidetes F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_293522_1 572544.Ilyop_1872 1.32e-18 80.5 2DZTT@1|root,32VIQ@2|Bacteria,37AMR@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_293522_2 572544.Ilyop_1873 3.59e-45 158.0 COG0534@1|root,COG0534@2|Bacteria,3784J@32066|Fusobacteria 32066|Fusobacteria V Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - MatE k59_64356_1 387093.SUN_0071 2.54e-48 162.0 COG1961@1|root,COG1961@2|Bacteria,1Q5XK@1224|Proteobacteria,42TRW@68525|delta/epsilon subdivisions,2YQ0Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L PFAM Resolvase, N terminal domain - - - - - - - - - - - - HTH_7,Resolvase k59_751412_1 944547.ABLL_2803 2.3e-153 438.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2YMRZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_326330_1 90814.KL370891_gene518 7.61e-15 73.9 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,45ZV4@72273|Thiotrichales 72273|Thiotrichales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_326330_2 1117319.PSPO_04952 4.2e-26 104.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,2PZW1@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P cytochrome c1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_882564_2 1049564.TevJSym_aq00430 1.96e-39 137.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1J6DN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 OSCP k59_556111_1 187272.Mlg_1393 4.36e-122 365.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_915661_1 1123368.AUIS01000006_gene673 2.32e-74 237.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - - - - - - - - - - CitMHS k59_33099_1 1172190.M947_05125 5.59e-65 197.0 COG3668@1|root,COG3668@2|Bacteria,1N73M@1224|Proteobacteria,42V73@68525|delta/epsilon subdivisions,2YS2C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_33099_2 1172190.M947_05120 1.16e-41 137.0 2BMN5@1|root,32G7D@2|Bacteria,1PVKA@1224|Proteobacteria,434BX@68525|delta/epsilon subdivisions,2YSN7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative addiction module component - - - - - - - - - - - - Unstab_antitox k59_33099_3 1120705.FG95_02151 5.33e-08 51.2 28XTK@1|root,2ZJQ1@2|Bacteria,1MZJV@1224|Proteobacteria,2UCH0@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterized small protein (DUF2158) - - - - - - - - - - - - DUF2158 k59_719573_1 1123377.AUIV01000001_gene876 1.55e-61 202.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1X4R7@135614|Xanthomonadales 135614|Xanthomonadales E Prephenate dehydratase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_719573_2 314285.KT71_10829 0.000148 43.1 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1J7WJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_0998,iECNA114_1301.ECNA114_0940,iECSF_1327.ECSF_0829,iPC815.YPO1390 EPSP_synthase k59_65733_1 933262.AXAM01000077_gene1699 1.77e-95 285.0 COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,2MI36@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM oxidoreductase FAD NAD(P)-binding domain protein nfnB - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_131105_1 375286.mma_3114 2.37e-91 297.0 COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,472JM@75682|Oxalobacteraceae 28216|Betaproteobacteria C Domain of unknown function (DUF3400) glpCD - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_261911_1 667015.Bacsa_2101 6.27e-84 269.0 COG2272@1|root,COG2272@2|Bacteria,4NG5B@976|Bacteroidetes,2FP5J@200643|Bacteroidia,4AKWU@815|Bacteroidaceae 976|Bacteroidetes I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_784879_1 1380387.JADM01000006_gene1251 1.86e-06 51.2 COG3937@1|root,COG3937@2|Bacteria,1N7X8@1224|Proteobacteria,1T08C@1236|Gammaproteobacteria,1XQHE@135619|Oceanospirillales 135619|Oceanospirillales S Poly(hydroxyalcanoate) granule associated protein (phasin) - - - - - - - - - - - - Phasin k59_784879_2 1123377.AUIV01000001_gene884 1.36e-25 107.0 COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria,1X4R5@135614|Xanthomonadales 135614|Xanthomonadales S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_425321_1 1122925.KB895376_gene566 1.78e-07 50.4 COG1551@1|root,COG1551@2|Bacteria,1VEEF@1239|Firmicutes,4HNPJ@91061|Bacilli,26ZW4@186822|Paenibacillaceae 91061|Bacilli T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_196511_2 1168034.FH5T_11215 1.67e-23 95.5 2B5KV@1|root,31YFX@2|Bacteria,4NQRP@976|Bacteroidetes,2FY4M@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_588838_1 1249480.B649_00085 2.62e-87 275.0 COG0617@1|root,COG1418@1|root,COG0617@2|Bacteria,COG1418@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2YMGU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H tRNA nucleotidyltransferase poly(A) polymerase cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_392689_1 387093.SUN_1721 3.95e-83 261.0 COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,42N3C@68525|delta/epsilon subdivisions,2YNS9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysN - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - GTP_EFTU,GTP_EFTU_D3 k59_621503_1 886379.AEWI01000023_gene8 3.37e-186 538.0 COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,2FMBR@200643|Bacteroidia,3XJ41@558415|Marinilabiliaceae 976|Bacteroidetes L RQC recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_65742_2 1283300.ATXB01000002_gene3188 3.51e-62 195.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1XEYU@135618|Methylococcales 135618|Methylococcales S EVE domain - - - - - - - - - - - - EVE k59_915675_1 471854.Dfer_2546 4.25e-35 127.0 COG3000@1|root,COG3000@2|Bacteria,4NMV7@976|Bacteroidetes,47PA0@768503|Cytophagia 976|Bacteroidetes I Fatty acid hydroxylase - - - - - - - - - - - - FA_hydroxylase k59_588844_1 1041146.ATZB01000008_gene2192 5.42e-85 270.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_196521_1 1168034.FH5T_20730 1.6e-108 325.0 COG0059@1|root,COG0059@2|Bacteria,4NFYV@976|Bacteroidetes,2FN0U@200643|Bacteroidia 976|Bacteroidetes E Ketol-acid reductoisomerase ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_686878_1 1304888.ATWF01000001_gene788 4.35e-29 115.0 COG0436@1|root,COG0436@2|Bacteria,2GENK@200930|Deferribacteres 200930|Deferribacteres E Aminotransferase class I and II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_686878_3 1366050.N234_22595 3.81e-38 139.0 COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2W0Q1@28216|Betaproteobacteria,1K5B3@119060|Burkholderiaceae 28216|Betaproteobacteria S membrane - - - - - - - - - - - - VIT1 k59_313_1 1249997.JHZW01000002_gene495 3.78e-51 179.0 COG0025@1|root,COG0025@2|Bacteria,4NK07@976|Bacteroidetes,1HWM6@117743|Flavobacteriia,2PGEI@252356|Maribacter 976|Bacteroidetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_313_2 1168034.FH5T_20510 1.1e-72 225.0 COG0568@1|root,COG0568@2|Bacteria,4NEBF@976|Bacteroidetes,2FNVQ@200643|Bacteroidia 976|Bacteroidetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_784889_2 1442598.JABW01000004_gene151 1.89e-203 582.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions 1224|Proteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_458085_1 1168034.FH5T_04590 2.09e-133 402.0 COG1185@1|root,COG1185@2|Bacteria,4NE4Q@976|Bacteroidetes,2FN5H@200643|Bacteroidia 976|Bacteroidetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1013767_1 765911.Thivi_1269 4.9e-58 187.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WZ7F@135613|Chromatiales 135613|Chromatiales E TIGRFAM ATP phosphoribosyltransferase, C-terminal domain - - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_1013767_2 1255043.TVNIR_2187 5.14e-12 65.5 COG0500@1|root,COG4797@1|root,COG0500@2|Bacteria,COG4797@2|Bacteria,1MX2X@1224|Proteobacteria,1S5U9@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Predicted methyltransferase regulatory domain - - - - - - - - - - - - MethyTransf_Reg,Methyltransf_25,Methyltransf_31 k59_719597_1 749222.Nitsa_1918 2.48e-07 52.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,42SB8@68525|delta/epsilon subdivisions,2YPI9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA gidB - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_131130_1 396588.Tgr7_1478 4.69e-92 295.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,1WXMT@135613|Chromatiales 135613|Chromatiales V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_327380_1 387093.SUN_0962 3.11e-107 327.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2YMGU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H tRNA nucleotidyltransferase poly(A) polymerase cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_719603_1 439235.Dalk_1292 8.56e-40 149.0 COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MINT@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Sigma54_activat k59_915710_1 555779.Dthio_PD3704 2.7e-77 246.0 COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66 k59_490734_1 1165841.SULAR_05988 3.51e-90 271.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2YP5V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NOU Peptidase A24 pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_163907_1 1121403.AUCV01000001_gene703 1.05e-150 431.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,42MJ3@68525|delta/epsilon subdivisions,2WKD5@28221|Deltaproteobacteria,2MHQC@213118|Desulfobacterales 28221|Deltaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_261956_1 1168034.FH5T_02765 3.82e-120 348.0 2C8XG@1|root,2Z7PK@2|Bacteria,4NEU8@976|Bacteroidetes,2FS5N@200643|Bacteroidia 976|Bacteroidetes S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_360052_1 387093.SUN_0664 4.33e-123 360.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2YM8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_686916_1 765912.Thimo_2538 3.69e-29 114.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_686916_2 1504981.KO116_1980 1.07e-75 239.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1XI7V@135619|Oceanospirillales 135619|Oceanospirillales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_327407_1 903818.KI912268_gene2066 1.07e-92 287.0 COG1053@1|root,COG1053@2|Bacteria 2|Bacteria C succinate dehydrogenase - - - - - - - - - - - - FAD_binding_2 k59_950226_1 1249627.D779_2341 1.19e-74 238.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales 135613|Chromatiales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1597_1 102107.XP_008224000.1 1.13e-50 182.0 28JZI@1|root,2QSDY@2759|Eukaryota,37J4T@33090|Viridiplantae,3GC2Z@35493|Streptophyta,4JREA@91835|fabids 35493|Streptophyta U Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope ycf1 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009507,GO:0009526,GO:0009528,GO:0009536,GO:0009706,GO:0009941,GO:0015031,GO:0015833,GO:0016020,GO:0019866,GO:0031090,GO:0031967,GO:0031969,GO:0031975,GO:0033036,GO:0042170,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - - - - - - - - - - Ycf1 k59_329225_1 1449063.JMLS01000034_gene2394 3.85e-67 211.0 COG1309@1|root,COG1309@2|Bacteria,1VBY5@1239|Firmicutes,4IQ25@91061|Bacilli,26X0B@186822|Paenibacillaceae 91061|Bacilli K Bacterial regulatory proteins, tetR family - - - ko:K22106 - - - - ko00000,ko03000 - - - TetR_C_10,TetR_N k59_329225_2 1132442.KB889752_gene451 4.99e-74 241.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,4HCXR@91061|Bacilli,1ZRHZ@1386|Bacillus 91061|Bacilli G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_950229_1 1123401.JHYQ01000008_gene411 1.01e-108 332.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,460VE@72273|Thiotrichales 72273|Thiotrichales S Sodium:solute symporter family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_394444_1 1528106.JRJE01000032_gene2642 2.32e-104 314.0 COG4988@1|root,COG4988@2|Bacteria,1QZBS@1224|Proteobacteria 1224|Proteobacteria CO ABC transporter - - - - - - - - - - - - - k59_884502_2 1196095.GAPWK_0100 4.47e-35 127.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 ATP-synt_A k59_198221_1 1336233.JAEH01000017_gene3216 7.01e-135 413.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,2Q9P8@267890|Shewanellaceae 1236|Gammaproteobacteria G PFAM D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase xfp - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_361952_2 589865.DaAHT2_0063 1.11e-33 132.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales 28221|Deltaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_884505_1 317025.Tcr_0118 5.65e-05 52.4 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,4629D@72273|Thiotrichales 72273|Thiotrichales M AsmA family - - - ko:K07289 - - - - ko00000 - - - AsmA k59_231092_1 1165841.SULAR_08497 1.2e-92 285.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,42MYF@68525|delta/epsilon subdivisions,2YMXD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Single-stranded-DNA-specific exonuclease (RecJ) recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_786625_1 387093.SUN_0212 7.07e-90 271.0 COG0602@1|root,COG0602@2|Bacteria,1PDNI@1224|Proteobacteria,42R24@68525|delta/epsilon subdivisions,2YN2N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14 k59_656209_2 675816.VIA_002785 2.53e-26 110.0 2DPCB@1|root,331HJ@2|Bacteria,1NED4@1224|Proteobacteria,1SGZF@1236|Gammaproteobacteria,1XYAZ@135623|Vibrionales 135623|Vibrionales S Putative phage abortive infection protein - - - - - - - - - - - - putAbiC k59_296310_2 391625.PPSIR1_27383 1.5e-69 227.0 COG2070@1|root,COG2070@2|Bacteria,1MWMI@1224|Proteobacteria,42P2I@68525|delta/epsilon subdivisions,2WK0M@28221|Deltaproteobacteria,2YYQD@29|Myxococcales 28221|Deltaproteobacteria C TIGRFAM PfaD family protein - - - - - - - - - - - - NMO k59_819340_2 266117.Rxyl_0050 6.83e-102 307.0 COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4CPEH@84995|Rubrobacteria 84995|Rubrobacteria G 6-phosphogluconate dehydrogenase, C-terminal domain - - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_819340_3 439235.Dalk_3007 1.62e-173 506.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2MMYN@213118|Desulfobacterales 28221|Deltaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_819340_4 525904.Tter_0412 6.46e-23 100.0 COG0363@1|root,COG0363@2|Bacteria,2NPBM@2323|unclassified Bacteria 2|Bacteria G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase pgl - 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R00765,R02035 RC00163,RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_819340_5 1216362.B437_04435 6.25e-81 250.0 COG1183@1|root,COG1183@2|Bacteria,379IK@32066|Fusobacteria 32066|Fusobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_558615_1 1437824.BN940_05701 1.66e-116 349.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,3T25I@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_166346_1 983328.AFGH01000030_gene570 1.09e-29 110.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,42RF8@68525|delta/epsilon subdivisions,2YP7F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT Chemotaxis protein cheY cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_166346_2 525898.Sdel_0306 1.32e-05 46.6 28K48@1|root,2Z9T8@2|Bacteria,1R4TF@1224|Proteobacteria,42MAD@68525|delta/epsilon subdivisions,2YQ5M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF4405) - - - - - - - - - - - - DUF4405 k59_983153_1 1044.EH31_13120 4.1e-92 278.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2TQUM@28211|Alphaproteobacteria,2K13E@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - Alpha-E k59_460574_1 398527.Bphyt_3115 5.36e-40 143.0 COG1192@1|root,COG1192@2|Bacteria,1R6KZ@1224|Proteobacteria,2W76M@28216|Betaproteobacteria,1KDYG@119060|Burkholderiaceae 28216|Betaproteobacteria D AAA domain - - - - - - - - - - - - AAA_31 k59_34994_1 1121440.AUMA01000011_gene2336 8.11e-77 245.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2M8HN@213115|Desulfovibrionales 28221|Deltaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - GAF_2,HTH_8,Sigma54_activat k59_787176_1 709032.Sulku_2000 7.74e-101 306.0 COG0446@1|root,COG0446@2|Bacteria,1PWV7@1224|Proteobacteria,42QCM@68525|delta/epsilon subdivisions,2YND4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG1252 NADH dehydrogenase FAD-containing subunit - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_918274_1 1120946.AUBF01000009_gene1073 3.87e-16 78.6 COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,4D43J@85005|Actinomycetales 201174|Actinobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_918274_2 373903.Hore_14640 6.51e-93 284.0 COG0330@1|root,COG0330@2|Bacteria,1W711@1239|Firmicutes,25IRK@186801|Clostridia,3WC5Y@53433|Halanaerobiales 186801|Clostridia O prohibitin homologues - - - - - - - - - - - - Band_7 k59_427431_1 1080067.BAZH01000036_gene1795 2.33e-93 285.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,3WY1P@544|Citrobacter 1236|Gammaproteobacteria C NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus gpsA GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iJN746.PP_4169,iSFV_1184.SFV_3923 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_754285_1 1122185.N792_08755 8.39e-37 130.0 COG2839@1|root,COG2839@2|Bacteria,1MZEV@1224|Proteobacteria,1SAFY@1236|Gammaproteobacteria,1X6YB@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - ko:K09793 - - - - ko00000 - - - DUF456 k59_133658_1 933262.AXAM01000025_gene3411 3.54e-94 284.0 COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,2MICY@213118|Desulfobacterales 28221|Deltaproteobacteria S nucleic acid binding OB-fold tRNA helicase-type yhaM - - ko:K03698 - - - - ko00000,ko01000,ko03019 - - - HD,tRNA_anti-codon k59_884974_1 929558.SMGD1_1597 1.1e-163 471.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42QGA@68525|delta/epsilon subdivisions,2YRI2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX k59_884974_2 1167006.UWK_03304 2.52e-71 225.0 COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria,42MIS@68525|delta/epsilon subdivisions,2WMK7@28221|Deltaproteobacteria,2MJNM@213118|Desulfobacterales 28221|Deltaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_198736_1 1333856.L686_05215 2.39e-148 439.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1Z28Q@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily - - - - - - - - - - - - Sulfatase k59_460582_1 768671.ThimaDRAFT_1692 9.66e-97 293.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,1WWQR@135613|Chromatiales 135613|Chromatiales E PFAM Cys Met metabolism - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_525855_1 243233.MCA1741 7.32e-119 347.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1SKVW@1236|Gammaproteobacteria,1XDNK@135618|Methylococcales 135618|Methylococcales H Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit - - 6.2.1.9 ko:K08692 ko00630,ko00680,ko01120,ko01200,map00630,map00680,map01120,map01200 M00346 R01256 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_1015940_1 1168034.FH5T_04365 8.11e-77 251.0 COG0457@1|root,COG0457@2|Bacteria,4NDTY@976|Bacteroidetes 976|Bacteroidetes C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_19,TPR_8 k59_656835_1 1191523.MROS_0021 7.42e-126 370.0 COG3104@1|root,COG3104@2|Bacteria 2|Bacteria E oligopeptide transport - - - ko:K03305 - - - - ko00000 2.A.17 - - MFS_1,PTR2 k59_1932_1 1302286.BAOT01000012_gene868 2.82e-36 137.0 COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,4HA89@91061|Bacilli,3F3KB@33958|Lactobacillaceae 91061|Bacilli F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_1932_2 1049564.TevJSym_by00060 1.17e-49 160.0 2E7PJ@1|root,33255@2|Bacteria,1NANJ@1224|Proteobacteria,1SDCV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1932_3 765910.MARPU_01895 2.42e-245 680.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_1932_4 292415.Tbd_1500 4.62e-257 724.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KSG5@119069|Hydrogenophilales 119069|Hydrogenophilales C Inorganic H+ pyrophosphatase - - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_591038_1 572544.Ilyop_1720 1.09e-54 188.0 COG0768@1|root,COG0768@2|Bacteria,378W3@32066|Fusobacteria 32066|Fusobacteria M penicillin-binding protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_591038_3 572544.Ilyop_1722 1.22e-21 87.0 COG0799@1|root,COG0799@2|Bacteria,37B3G@32066|Fusobacteria 32066|Fusobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_395003_1 867900.Celly_2211 1.6e-82 258.0 COG0635@1|root,COG0635@2|Bacteria,4NEY5@976|Bacteroidetes,1HYDQ@117743|Flavobacteriia,1F7TV@104264|Cellulophaga 976|Bacteroidetes H COGs COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase hemN - - - - - - - - - - - HemN_C,Radical_SAM k59_166372_1 1120980.JQKH01000001_gene650 1.4e-66 229.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,2KPG8@206351|Neisseriales 206351|Neisseriales C Psort location Cytoplasmic, score sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_296830_1 765910.MARPU_12605 7.58e-145 436.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_852801_1 929558.SMGD1_2516 1.9e-60 191.0 COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,42RGX@68525|delta/epsilon subdivisions,2YPA8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TIGRFAM DJ-1 family protein thiJ - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_35020_1 926556.Echvi_1668 3.23e-82 270.0 COG3250@1|root,COG3250@2|Bacteria,4NEWP@976|Bacteroidetes,47T9A@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Malectin k59_100822_1 1117647.M5M_15080 3.14e-70 228.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1J4NK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_656854_1 1168034.FH5T_20685 9.79e-111 341.0 COG5640@1|root,COG5640@2|Bacteria,4PKEW@976|Bacteroidetes,2FRKU@200643|Bacteroidia 976|Bacteroidetes O Trypsin-like peptidase domain - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - Trypsin_2 k59_231660_2 420662.Mpe_A3611 4.35e-31 116.0 COG1708@1|root,COG1708@2|Bacteria,1RCAH@1224|Proteobacteria,2WAA3@28216|Betaproteobacteria,1KNX1@119065|unclassified Burkholderiales 28216|Betaproteobacteria S TRANSCRIPTIONal - - - - - - - - - - - - - k59_852806_1 933262.AXAM01000001_gene360 2.36e-78 247.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2WISS@28221|Deltaproteobacteria,2MHQH@213118|Desulfobacterales 28221|Deltaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_623777_1 273121.WS1617 4.02e-76 234.0 COG1468@1|root,COG1468@2|Bacteria,1N46Y@1224|Proteobacteria,43B2X@68525|delta/epsilon subdivisions,2YRJ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Domain of unknown function DUF83 - - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas4 k59_656859_1 314225.ELI_09260 2.39e-29 122.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K2G6@204457|Sphingomonadales 204457|Sphingomonadales EQ COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_198760_1 459495.SPLC1_S371110 4.3e-82 275.0 COG0438@1|root,COG0457@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,1FZUY@1117|Cyanobacteria,1HI7Q@1150|Oscillatoriales 1117|Cyanobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,TPR_11,TPR_2,TPR_7,TPR_8 k59_1015965_1 1168034.FH5T_18945 1.53e-57 192.0 COG0504@1|root,COG0504@2|Bacteria,4NEWT@976|Bacteroidetes,2FMC4@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1015965_2 1168034.FH5T_18950 1.72e-21 94.7 COG0706@1|root,COG0706@2|Bacteria,4NESJ@976|Bacteroidetes,2FN3A@200643|Bacteroidia 976|Bacteroidetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_754319_1 1144275.COCOR_01063 7.5e-54 183.0 COG0596@1|root,COG0596@2|Bacteria,1QVBQ@1224|Proteobacteria 1224|Proteobacteria S Alpha beta hydrolase - - - - - - - - - - - - - k59_918326_1 1168034.FH5T_07155 5.93e-54 177.0 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - DUF4367,LolA,LolA_like k59_329843_1 1122134.KB893651_gene2166 1.45e-09 69.7 COG0745@1|root,COG0784@1|root,COG2198@1|root,COG4251@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1XRSE@135619|Oceanospirillales 135619|Oceanospirillales T Histidine Phosphotransfer domain - - 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HATPase_c,HisKA,Hpt,Response_reg k59_329843_2 572544.Ilyop_0460 1.57e-83 252.0 COG0817@1|root,COG0817@2|Bacteria,37A4F@32066|Fusobacteria 32066|Fusobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_329843_3 572544.Ilyop_0459 3.66e-93 282.0 COG0568@1|root,COG0568@2|Bacteria,379W4@32066|Fusobacteria 32066|Fusobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086,ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_329843_4 572544.Ilyop_0458 7.47e-142 409.0 COG0492@1|root,COG0492@2|Bacteria,378XX@32066|Fusobacteria 32066|Fusobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3 k59_329843_5 1384056.N787_04360 2.58e-07 52.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1X7P3@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional - - - - - - - - - - - - HTH_5 k59_329843_6 742817.HMPREF9449_01296 2.72e-20 92.0 COG0491@1|root,COG0491@2|Bacteria,4NE2Y@976|Bacteroidetes,2FSQ1@200643|Bacteroidia,22XXM@171551|Porphyromonadaceae 976|Bacteroidetes P metallo-beta-lactamase - - - - - - - - - - - - Lactamase_B k59_558670_1 1237149.C900_03312 2.85e-18 86.3 COG1249@1|root,COG1249@2|Bacteria,4NJ2P@976|Bacteroidetes,47NRN@768503|Cytophagia 976|Bacteroidetes C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_558670_2 177437.HRM2_08540 1.58e-177 506.0 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,42KZ4@68525|delta/epsilon subdivisions,2WKT2@28221|Deltaproteobacteria,2MI6U@213118|Desulfobacterales 28221|Deltaproteobacteria EGP PFAM Major Facilitator Superfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_100848_1 1410676.JNKL01000005_gene365 3.66e-11 63.2 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1Y3JI@135624|Aeromonadales 135624|Aeromonadales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_100848_2 472759.Nhal_0333 1.67e-36 126.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1WYWY@135613|Chromatiales 135613|Chromatiales J Sigma 54 modulation protein - - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_950853_1 1121447.JONL01000001_gene735 7.46e-26 97.4 2EG8N@1|root,33A0G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_67965_1 545264.KB898746_gene836 6.95e-65 212.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1X0VD@135613|Chromatiales 135613|Chromatiales F Belongs to the dGTPase family. Type 2 subfamily - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_885019_1 1026882.MAMP_02611 1.43e-135 396.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,45ZNF@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_329855_1 469616.FMAG_01746 2.68e-70 221.0 COG0648@1|root,COG0648@2|Bacteria,378DZ@32066|Fusobacteria 32066|Fusobacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_329856_1 871585.BDGL_003454 1.37e-26 102.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,3NK7Y@468|Moraxellaceae 1236|Gammaproteobacteria E Acetolactate synthase small ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1906,iECNA114_1301.ECNA114_0072,iEcSMS35_1347.EcSMS35_0084,iG2583_1286.G2583_0082,iSFxv_1172.SFxv_0077,iUTI89_1310.UTI89_C0086 ACT,ACT_5,ALS_ss_C k59_329856_2 314278.NB231_04980 1.15e-20 91.3 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H acetolactate synthase ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_35055_1 326298.Suden_0279 5.95e-162 481.0 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,42PHJ@68525|delta/epsilon subdivisions,2YNKV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_67971_1 118166.JH976537_gene2235 7.63e-74 250.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria,1H9JF@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Conserved region in glutamate synthase gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.7.1 ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 - R00021,R10086 RC00006,RC00010 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_950865_1 749222.Nitsa_0863 4.77e-137 398.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2YMD3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_656892_1 1168034.FH5T_05795 5.06e-214 629.0 COG3250@1|root,COG3250@2|Bacteria,4NKZX@976|Bacteroidetes,2FNTC@200643|Bacteroidia 976|Bacteroidetes G Beta galactosidase small chain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3 k59_460647_1 1348635.BBJY01000019_gene593 1.37e-98 295.0 COG2604@1|root,COG2604@2|Bacteria,1NNJY@1224|Proteobacteria,1SI36@1236|Gammaproteobacteria,1XWMN@135623|Vibrionales 135623|Vibrionales N Protein of unknown function DUF115 - - - - - - - - - - - - - k59_623812_2 504472.Slin_5641 4.2e-23 97.1 COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,47JZA@768503|Cytophagia 976|Bacteroidetes I acyl-CoA dehydrogenase acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_231700_1 1318628.MARLIPOL_04455 1.94e-41 155.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,4643D@72275|Alteromonadaceae 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_232529_1 1121405.dsmv_2513 8e-39 142.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,42S0M@68525|delta/epsilon subdivisions,2WNYE@28221|Deltaproteobacteria,2MMEA@213118|Desulfobacterales 28221|Deltaproteobacteria S alpha/beta hydrolase fold yheT - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1,Abhydrolase_6 k59_591562_1 713587.THITH_15960 6.26e-101 305.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales 135613|Chromatiales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_330858_1 861299.J421_1235 3.88e-31 117.0 COG0637@1|root,COG0637@2|Bacteria,1ZTWJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_330858_2 1123253.AUBD01000009_gene2220 1.22e-22 92.8 COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,1S2I8@1236|Gammaproteobacteria,1X3PP@135614|Xanthomonadales 135614|Xanthomonadales O maleylacetoacetate isomerase uptB - 5.2.1.2 ko:K01800 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R03181 RC00867 ko00000,ko00001,ko00002,ko01000 - - - GST_C_2,GST_N,GST_N_3 k59_722739_1 563040.Saut_0629 6.02e-63 208.0 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,42RPB@68525|delta/epsilon subdivisions,2YP5G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q ABC-type transport system involved in resistance to organic solvents periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_101931_1 497321.C664_04072 1.49e-76 250.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,2KU6T@206389|Rhodocyclales 206389|Rhodocyclales I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_591564_1 1366046.HIMB11_02415 1.11e-72 230.0 COG0683@1|root,COG0683@2|Bacteria,1PF5W@1224|Proteobacteria,2V88D@28211|Alphaproteobacteria,3ZIK4@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria E Receptor family ligand binding region - - - - - - - - - - - - - k59_952254_1 519989.ECTPHS_03879 8.49e-96 290.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales 135613|Chromatiales HJ Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_658556_1 768671.ThimaDRAFT_0602 1.68e-95 310.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_592271_2 1122243.KB903811_gene802 2.93e-10 59.7 COG1487@1|root,COG1487@2|Bacteria,1RJDP@1224|Proteobacteria,1SA6Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase vapC - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN k59_821563_1 1209072.ALBT01000004_gene678 5.14e-22 102.0 COG2931@1|root,COG4254@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4254@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1FGNW@10|Cellvibrio 1236|Gammaproteobacteria MQ Cadherin-like - - - - - - - - - - - - Cadherin,Cadherin_3,HemolysinCabind,PA14 k59_428850_1 1329516.JPST01000022_gene2554 5.21e-42 159.0 COG2227@1|root,COG3321@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4IUUB@91061|Bacilli,27AWN@186824|Thermoactinomycetaceae 91061|Bacilli Q Beta-ketoacyl synthase - - - - - - - - - - - - KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt k59_755735_1 345341.KUTG_00801 1.43e-49 171.0 COG1237@1|root,COG1237@2|Bacteria,2I8H7@201174|Actinobacteria,4DZYW@85010|Pseudonocardiales 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_658560_1 643867.Ftrac_0991 9.37e-55 195.0 COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,47Y5N@768503|Cytophagia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_690747_1 1454004.AW11_04008 5.15e-17 83.6 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2VKCK@28216|Betaproteobacteria,1KQVQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Biotin-lipoyl like mdtA_2 - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_690747_2 649747.HMPREF0083_05602 0.000894 42.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4HAFP@91061|Bacilli,26SD1@186822|Paenibacillaceae 91061|Bacilli V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrB1 - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_527704_1 572544.Ilyop_0361 8.33e-119 366.0 COG0013@1|root,COG0013@2|Bacteria,378SD@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_527704_2 469618.FVAG_00295 1.19e-63 197.0 COG0816@1|root,COG0816@2|Bacteria,37AC0@32066|Fusobacteria 32066|Fusobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_527704_3 572544.Ilyop_0363 7.49e-45 156.0 COG0342@1|root,COG0342@2|Bacteria,3791U@32066|Fusobacteria 32066|Fusobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_625352_1 631362.Thi970DRAFT_03315 1.35e-45 162.0 COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,1RPGR@1236|Gammaproteobacteria,1WWYY@135613|Chromatiales 135613|Chromatiales S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_755739_1 1218103.CIN01S_11_00420 5.11e-18 90.1 2EWAU@1|root,33PPI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_854258_1 713586.KB900536_gene61 1.6e-68 216.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales 135613|Chromatiales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_102744_1 861452.HMPREF9093_00071 5.26e-103 319.0 COG0480@1|root,COG0480@2|Bacteria,3787D@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score 9.97 - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_135510_1 1122134.KB893650_gene375 1.48e-14 73.9 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1XHIS@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_135510_2 765910.MARPU_04190 1.88e-56 183.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_2943_1 349124.Hhal_1204 3.6e-73 233.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1WWCI@135613|Chromatiales 135613|Chromatiales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_690749_1 483219.LILAB_32210 9.56e-61 202.0 2DVFS@1|root,33VPK@2|Bacteria,1R0IR@1224|Proteobacteria 1224|Proteobacteria S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_690749_2 555779.Dthio_PD3706 1.92e-57 180.0 COG3436@1|root,COG3436@2|Bacteria,1N638@1224|Proteobacteria,430NK@68525|delta/epsilon subdivisions,2WVZ0@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM IS66 Orf2 family protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_363921_1 1121423.JONT01000001_gene1843 6.09e-66 226.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,NAD_binding_8,Pyr_redox_2 k59_1017620_1 1134474.O59_000710 9.47e-08 55.5 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNR@1236|Gammaproteobacteria,1FI9E@10|Cellvibrio 1236|Gammaproteobacteria C Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_1017620_2 525903.Taci_1620 9.27e-48 157.0 COG1898@1|root,COG1898@2|Bacteria,3TB9Y@508458|Synergistetes 508458|Synergistetes M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose - - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_952269_1 1319815.HMPREF0202_01631 1.26e-42 150.0 COG1160@1|root,COG1160@2|Bacteria,379J8@32066|Fusobacteria 32066|Fusobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_952269_2 1319815.HMPREF0202_01630 4.39e-82 260.0 COG1032@1|root,COG1032@2|Bacteria,378NN@32066|Fusobacteria 32066|Fusobacteria C Radical SAM N-terminal - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_658574_1 715451.ambt_07655 2.36e-75 246.0 COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria,464Q7@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.135 ko:K21575 - - - - ko00000,ko01000 - GH13 - Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N k59_658577_2 1492738.FEM21_07010 0.000138 43.5 COG2195@1|root,COG2195@2|Bacteria,4NE7N@976|Bacteroidetes,1HWV8@117743|Flavobacteriia,2NTXK@237|Flavobacterium 976|Bacteroidetes E Cleaves the N-terminal amino acid of tripeptides pepT - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_396679_1 521719.ATXQ01000002_gene2661 4.23e-74 226.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1YEZY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_331565_1 713587.THITH_07515 6.31e-71 236.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1WW7D@135613|Chromatiales 135613|Chromatiales C Molybdopterin oxidoreductase Fe4S4 domain napA - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_331565_2 768671.ThimaDRAFT_4409 1.89e-99 297.0 COG0437@1|root,COG0437@2|Bacteria,1N9WY@1224|Proteobacteria,1RNHT@1236|Gammaproteobacteria,1WY71@135613|Chromatiales 135613|Chromatiales C 4Fe-4S binding domain - - - ko:K02573 - - - - ko00000 - - - Fer4,Fer4_4,Fer4_7 k59_331565_3 1255043.TVNIR_1331 1.81e-77 241.0 COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,1RQ1I@1236|Gammaproteobacteria,1X0MW@135613|Chromatiales 135613|Chromatiales C 4Fe-4S binding domain - - - ko:K02574 - - - - ko00000 - - - Fer4_5 k59_625376_1 1172190.M947_09030 4.41e-34 129.0 COG0589@1|root,COG0589@2|Bacteria,1PGYC@1224|Proteobacteria,42VCH@68525|delta/epsilon subdivisions 1224|Proteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_625376_2 387092.NIS_0009 0.000155 43.9 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,42PEH@68525|delta/epsilon subdivisions,2YTDD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E -Amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_102777_1 1049564.TevJSym_bb00160 5.38e-51 167.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_265448_1 395493.BegalDRAFT_1750 2.2e-93 301.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,461RZ@72273|Thiotrichales 72273|Thiotrichales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_592311_1 1168034.FH5T_06485 3.69e-207 602.0 COG3291@1|root,COG4447@1|root,COG3291@2|Bacteria,COG4447@2|Bacteria,4NGJJ@976|Bacteroidetes,2FRXF@200643|Bacteroidia 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - - k59_36608_1 1391646.AVSU01000061_gene1053 5.03e-166 475.0 COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,25SKW@186804|Peptostreptococcaceae 186801|Clostridia C Psort location Cytoplasmic, score - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_36608_2 572544.Ilyop_1591 5.37e-122 357.0 COG1149@1|root,COG1149@2|Bacteria,379V4@32066|Fusobacteria 32066|Fusobacteria C CobQ/CobB/MinD/ParA nucleotide binding domain - - - - - - - - - - - - CbiA,Fer4 k59_36608_3 572544.Ilyop_1590 7.06e-117 344.0 COG1149@1|root,COG1149@2|Bacteria,37895@32066|Fusobacteria 32066|Fusobacteria C NUBPL iron-transfer P-loop NTPase - - - - - - - - - - - - CbiA,Fer4 k59_36608_4 572544.Ilyop_1589 8.44e-52 166.0 COG1433@1|root,COG1433@2|Bacteria,37B3W@32066|Fusobacteria 32066|Fusobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_36608_5 938278.CAJO01000048_gene466 4.16e-12 66.2 COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - C_GCAxxG_C_C k59_36608_7 1343739.PAP_04050 5.92e-57 191.0 COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,242V0@183968|Thermococci 183968|Thermococci S Protein of unknown function DUF89 - - - ko:K09116 - - - - ko00000 - - - DUF89 k59_36608_8 880073.Calab_3139 5.5e-07 52.0 2DNMM@1|root,32Y53@2|Bacteria 2|Bacteria S Family of unknown function (DUF5320) - - - - - - - - - - - - DUF5320 k59_36608_9 572544.Ilyop_1587 9.93e-214 598.0 COG0489@1|root,COG1433@1|root,COG0489@2|Bacteria,COG1433@2|Bacteria,379BU@32066|Fusobacteria 32066|Fusobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - ParA k59_36608_10 579405.Dd703_3434 2.28e-15 72.8 COG1342@1|root,COG1342@2|Bacteria,1N80T@1224|Proteobacteria,1S9DC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0251 family - - - - - - - - - - - - DUF134 k59_69604_1 709032.Sulku_1390 1.99e-99 300.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2YMIC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_69604_2 314345.SPV1_09648 1.81e-61 204.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria 1224|Proteobacteria M murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division mltA - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA k59_1017643_1 406124.ACPC01000020_gene3775 8.73e-09 55.1 COG0607@1|root,COG0607@2|Bacteria,1VB3C@1239|Firmicutes,4HKWP@91061|Bacilli,1ZH86@1386|Bacillus 91061|Bacilli P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_1017643_2 1207076.ALAT01000215_gene4077 2.89e-29 107.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1Z38N@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_1017643_3 1123253.AUBD01000004_gene1109 6.59e-36 129.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1X65X@135614|Xanthomonadales 135614|Xanthomonadales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_1017643_4 630626.EBL_c38850 3.98e-91 279.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iJN746.PP_4169,iSFV_1184.SFV_3923 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_788786_1 1122951.ATUE01000011_gene476 5.75e-25 106.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,3NJK6@468|Moraxellaceae 1236|Gammaproteobacteria NU Bacterial type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - SPOR,Secretin,Secretin_N k59_821624_1 96561.Dole_0105 2.04e-63 202.0 COG0727@1|root,COG0727@2|Bacteria,1REPM@1224|Proteobacteria,42RPZ@68525|delta/epsilon subdivisions,2WNSE@28221|Deltaproteobacteria,2MIBR@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC k59_462548_1 1168034.FH5T_21970 7.43e-112 336.0 COG1640@1|root,COG1640@2|Bacteria,4NF7Z@976|Bacteroidetes,2FMBZ@200643|Bacteroidia 976|Bacteroidetes G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Alpha-amylase,Glyco_hydro_77 k59_625397_1 1237149.C900_02134 3.64e-113 344.0 COG1048@1|root,COG1048@2|Bacteria,4NDZT@976|Bacteroidetes,47TH4@768503|Cytophagia 976|Bacteroidetes C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_265459_1 861299.J421_0339 1.72e-85 269.0 COG2303@1|root,COG2303@2|Bacteria 2|Bacteria E choline dehydrogenase activity - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1017648_1 1321774.HMPREF9108_02019 4.04e-117 351.0 COG1640@1|root,COG1640@2|Bacteria,3799Y@32066|Fusobacteria 32066|Fusobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_298246_1 1906.SFRA_16745 8.5e-05 47.4 COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase type 11 - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_298246_2 326427.Cagg_0609 1.81e-13 65.5 COG1553@1|root,COG1553@2|Bacteria,2GB6X@200795|Chloroflexi,377GQ@32061|Chloroflexia 32061|Chloroflexia P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE - - - - - - - - - - - - DrsE k59_428888_1 177437.HRM2_12970 2.05e-72 253.0 COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,42N7P@68525|delta/epsilon subdivisions,2WMCJ@28221|Deltaproteobacteria,2MIH1@213118|Desulfobacterales 28221|Deltaproteobacteria S Lysylphosphatidylglycerol synthase TM region - - 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 - - DUF2156,LPG_synthase_TM k59_428888_2 945713.IALB_2951 7.59e-34 135.0 COG1408@1|root,COG1408@2|Bacteria 2|Bacteria S Calcineurin-like phosphoesterase Z012_05430 - - ko:K07098 - - - - ko00000 - - - Metallophos k59_560482_1 1121015.N789_05815 2.59e-52 180.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1X4IU@135614|Xanthomonadales 135614|Xanthomonadales S Protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_723415_1 1122929.KB908231_gene3603 1.64e-29 122.0 28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_592332_1 713586.KB900536_gene625 1.62e-56 189.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales 135613|Chromatiales L DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_36623_1 187272.Mlg_1877 8.48e-111 333.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales 135613|Chromatiales C TIGRFAM cytochrome c oxidase accessory protein - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_36623_2 1121921.KB898706_gene3170 1.27e-34 128.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,2PMSA@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C N-terminal domain of cytochrome oxidase-cbb3, FixP ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - iJN746.PP_4253 Cytochrome_CBB3,FixP_N k59_200309_1 397288.C806_03037 0.000373 46.2 COG0270@1|root,COG0270@2|Bacteria,1TS3G@1239|Firmicutes,249Q9@186801|Clostridia,27KBU@186928|unclassified Lachnospiraceae 186801|Clostridia H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_168369_1 1121289.JHVL01000017_gene764 1.28e-153 447.0 COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,36DNW@31979|Clostridiaceae 186801|Clostridia C FAD dependent oxidoreductase glpA - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD k59_428893_1 1168034.FH5T_20940 1.37e-37 131.0 2ENX1@1|root,33GHZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_428893_2 1168034.FH5T_20945 4.55e-37 132.0 COG0329@1|root,COG0329@2|Bacteria,4NFP9@976|Bacteroidetes,2FMFC@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_560486_1 1439940.BAY1663_04939 1.49e-16 84.7 COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_625411_1 944547.ABLL_0682 3.17e-96 290.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,42P5V@68525|delta/epsilon subdivisions,2YNBJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_821643_1 1120983.KB894571_gene2705 5.61e-21 97.4 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,1JN7I@119043|Rhodobiaceae 28211|Alphaproteobacteria L DNA polymerase IV dinB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C k59_723422_1 1123508.JH636441_gene3524 4.8e-34 124.0 COG3415@1|root,COG3415@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_23,HTH_28,HTH_32 k59_527788_2 1423321.AS29_07385 3.7e-37 136.0 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1ZERT@1386|Bacillus 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1017669_1 251229.Chro_4000 9.48e-68 214.0 COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,3VK4S@52604|Pleurocapsales 1117|Cyanobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_1017669_2 380358.XALC_3009 1.89e-05 46.6 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X38I@135614|Xanthomonadales 135614|Xanthomonadales V Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_396727_1 869213.JCM21142_1613 1e-13 77.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,47Y7H@768503|Cytophagia 976|Bacteroidetes H TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_462578_1 1168034.FH5T_21935 2.8e-98 310.0 COG4775@1|root,COG4775@2|Bacteria,4NE6Z@976|Bacteroidetes,2FM76@200643|Bacteroidia 976|Bacteroidetes M Outer membrane protein assembly complex, YaeT protein yaeT - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_821651_1 1395571.TMS3_0109550 6.55e-119 357.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) ychM GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - iSbBS512_1146.SbBS512_E1370 STAS,Sulfate_transp k59_592350_1 1265502.KB905938_gene2482 5.07e-90 271.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,4AC27@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_952333_1 207559.Dde_0758 5.02e-06 54.3 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42YXK@68525|delta/epsilon subdivisions,2WTKM@28221|Deltaproteobacteria,2MH9C@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,dCache_2 k59_822307_1 1123514.KB905899_gene841 5.62e-70 225.0 COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_3,HlyD_D23,OEP k59_626060_2 367336.OM2255_12617 8.08e-62 213.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the GcvT family soxA - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_364651_1 1239962.C943_01752 9.1e-17 85.1 COG1629@1|root,COG1629@2|Bacteria,4NF88@976|Bacteroidetes,47JEF@768503|Cytophagia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 k59_561142_1 1089551.KE386572_gene4536 8.97e-06 55.1 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2TT78@28211|Alphaproteobacteria,4BQ9K@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Dimerisation domain of Zinc Transporter fieF - - ko:K13283 - - - - ko00000,ko02000 2.A.4.7.1 - - Cation_efflux,ZT_dimer k59_561142_3 572544.Ilyop_1118 7.95e-175 504.0 COG2239@1|root,COG2239@2|Bacteria,378KN@32066|Fusobacteria 32066|Fusobacteria P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_266012_1 1348635.BBJY01000024_gene2159 1.09e-80 251.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1XSWY@135623|Vibrionales 135623|Vibrionales V Na driven multidrug efflux pump dinF - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_37230_1 187272.Mlg_1712 8.46e-297 840.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_136231_1 1454004.AW11_02478 2.33e-20 86.3 2EE2B@1|root,337X1@2|Bacteria,1N433@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_561145_1 1122223.KB890696_gene219 9e-85 266.0 COG0029@1|root,COG0029@2|Bacteria,1WIG5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H L-aspartate oxidase - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_626063_1 717772.THIAE_04355 7.67e-133 393.0 COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,1RP3V@1236|Gammaproteobacteria,461K4@72273|Thiotrichales 72273|Thiotrichales S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_3,Polysacc_synt_C k59_886953_2 944547.ABLL_2045 3.12e-08 64.3 COG1357@1|root,COG1357@2|Bacteria,1NCWB@1224|Proteobacteria,42WFQ@68525|delta/epsilon subdivisions,2YQN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Pentapeptide repeats (8 copies) - - - - - - - - - - - - Pentapeptide_3 k59_200913_2 585501.HMPREF6123_0806 1.77e-05 46.6 COG1396@1|root,COG1396@2|Bacteria,1UETJ@1239|Firmicutes,25JT0@186801|Clostridia,2PTQ9@265975|Oribacterium 186801|Clostridia K Protein of unknown function (DUF2442) - - - - - - - - - - - - DUF2442 k59_200913_3 1499967.BAYZ01000080_gene906 7.02e-31 110.0 2E3EN@1|root,32YDN@2|Bacteria,2NS2J@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4160) - - - - - - - - - - - - DUF4160 k59_200913_4 686340.Metal_2618 9.12e-31 114.0 2ASHK@1|root,31HXY@2|Bacteria,1PB7B@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_364659_1 933262.AXAM01000005_gene2474 7.25e-51 174.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,43AX8@68525|delta/epsilon subdivisions,2X6BG@28221|Deltaproteobacteria 1224|Proteobacteria T HD domain - - - - - - - - - - - - HD_5,Response_reg k59_463243_1 387093.SUN_2341 3.33e-69 216.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2YM98@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_332234_1 318161.Sden_0734 4.12e-10 67.4 COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1RZRN@1236|Gammaproteobacteria,2Q8R2@267890|Shewanellaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,TPR_12,TPR_7 k59_3397_1 879212.DespoDRAFT_02744 3.28e-131 398.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,2MJ3Q@213118|Desulfobacterales 28221|Deltaproteobacteria GM Polysaccharide biosynthesis protein - - - - - - - - - - - - CoA_binding_3,Polysacc_synt_2 k59_789410_1 293826.Amet_0894 2.18e-14 72.8 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36DYU@31979|Clostridiaceae 186801|Clostridia P Belongs to the ABC transporter superfamily msmX - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_789410_2 545693.BMQ_0457 1.56e-196 568.0 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,4HA5R@91061|Bacilli,1ZBRR@1386|Bacillus 91061|Bacilli G Alpha-galactosidase aga - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase k59_169109_1 1122236.KB905143_gene90 5.34e-13 69.7 COG1714@1|root,COG1714@2|Bacteria,1N7R6@1224|Proteobacteria,2WFRR@28216|Betaproteobacteria,2KN2M@206350|Nitrosomonadales 206350|Nitrosomonadales S RDD family - - - - - - - - - - - - RDD k59_169109_2 1168065.DOK_05078 2.65e-37 128.0 COG0347@1|root,COG0347@2|Bacteria,1MZ43@1224|Proteobacteria,1S9ZT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E nitrogen regulatory protein PII - - - - - - - - - - - - - k59_169109_3 494419.ALPM01000010_gene712 1.78e-89 273.0 COG3329@1|root,COG3329@2|Bacteria,2I8DP@201174|Actinobacteria 201174|Actinobacteria S Na+-dependent bicarbonate transporter superfamily - - - ko:K07086 - - - - ko00000 - - - Sbt_1 k59_169113_1 1304885.AUEY01000003_gene545 1.36e-39 147.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_397345_1 994573.T472_0219380 7.25e-192 548.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,36FU2@31979|Clostridiaceae 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE k59_397345_2 1262915.BN574_00890 2.57e-50 165.0 COG0789@1|root,COG0789@2|Bacteria,1V3QI@1239|Firmicutes,4H5R6@909932|Negativicutes 909932|Negativicutes K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_397345_3 742727.HMPREF9447_04937 4.62e-10 59.3 COG1454@1|root,COG1454@2|Bacteria,4NIU1@976|Bacteroidetes,2FP86@200643|Bacteroidia,4ANTE@815|Bacteroidaceae 976|Bacteroidetes C COG1454 Alcohol dehydrogenase class IV - - - - - - - - - - - - Fe-ADH k59_723988_2 1349822.NSB1T_11115 3.06e-36 137.0 COG0019@1|root,COG0210@1|root,COG0019@2|Bacteria,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,2FNIM@200643|Bacteroidia,22WFT@171551|Porphyromonadaceae 976|Bacteroidetes L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_659263_2 903814.ELI_4468 4.86e-45 156.0 COG0407@1|root,COG0407@2|Bacteria,1USM0@1239|Firmicutes,248G3@186801|Clostridia 186801|Clostridia H Methyltransferase MtaA CmuA family hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,URO-D k59_37261_1 1049564.TevJSym_ac01660 9.89e-65 205.0 COG1309@1|root,COG1309@2|Bacteria,1PH8D@1224|Proteobacteria,1RW67@1236|Gammaproteobacteria,1J77A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_463273_1 742817.HMPREF9449_01453 4.59e-08 52.8 COG1970@1|root,COG1970@2|Bacteria,4NQ49@976|Bacteroidetes,2FT2E@200643|Bacteroidia,22Y4Y@171551|Porphyromonadaceae 976|Bacteroidetes M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_463273_2 312153.Pnuc_1322 3.6e-24 94.0 COG4095@1|root,COG4095@2|Bacteria,1N759@1224|Proteobacteria,2VVPU@28216|Betaproteobacteria,1KB20@119060|Burkholderiaceae 28216|Betaproteobacteria S PQ loop repeat - - - ko:K15383 - - - - ko00000,ko02000 9.A.58.2 - - PQ-loop k59_103563_1 317936.Nos7107_1952 3.02e-21 98.6 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - ko:K07004 - - - - ko00000 - - - Calx-beta,DUF5122,Laminin_G_3 k59_200946_1 749222.Nitsa_0917 3.8e-21 87.8 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2YNX7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iIT341.HP1016 CDP-OH_P_transf k59_200946_2 1249480.B649_07490 3.97e-64 201.0 COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,42KZK@68525|delta/epsilon subdivisions,2YMUM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ dehydrogenase hdhA - 1.1.1.159 ko:K00076 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - adh_short_C2 k59_854983_1 1168034.FH5T_04755 4.53e-71 235.0 COG1509@1|root,COG1509@2|Bacteria,4NK6C@976|Bacteroidetes,2FMW5@200643|Bacteroidia 976|Bacteroidetes E KamA family eam - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - - k59_659274_1 1535422.ND16A_1887 2.18e-84 263.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,1RQ1A@1236|Gammaproteobacteria,2Q6Q9@267889|Colwelliaceae 1236|Gammaproteobacteria M PFAM membrane bound O-acyl transferase MBOAT family protein patA - - - - - - - - - - - MBOAT k59_332269_1 944547.ABLL_0078 1.66e-102 308.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2YMZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_169137_1 1163617.SCD_n00817 1.93e-25 102.0 COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria 28216|Betaproteobacteria K RNA polymerase sigE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_200953_1 177437.HRM2_46850 1.33e-10 61.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFQ@28221|Deltaproteobacteria,2MIXP@213118|Desulfobacterales 28221|Deltaproteobacteria T Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_200953_2 404380.Gbem_3878 1.27e-08 56.2 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_886998_1 326298.Suden_1474 1.79e-97 307.0 COG1287@1|root,COG1287@2|Bacteria,1R481@1224|Proteobacteria,42MNZ@68525|delta/epsilon subdivisions,2YMU3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Oligosaccharyl transferase, STT3 subunit pglB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0034645,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046872,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.99.18,2.4.99.19 ko:K07151,ko:K17251 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_561187_1 1168034.FH5T_12310 3.97e-254 713.0 COG3968@1|root,COG3968@2|Bacteria,4NG2B@976|Bacteroidetes,2FMC9@200643|Bacteroidia 976|Bacteroidetes S Glutamate--ammonia ligase, catalytic domain protein glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C k59_495457_1 1049564.TevJSym_ah00850 0.0 1080.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_495457_2 1036674.A28LD_2108 4.02e-17 88.2 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,2QFXN@267893|Idiomarinaceae 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_495457_3 472759.Nhal_1449 7.01e-303 847.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales 135613|Chromatiales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_495457_4 509191.AEDB02000028_gene2847 6.72e-30 125.0 COG1520@1|root,COG2304@1|root,COG1520@2|Bacteria,COG2304@2|Bacteria,1V5PN@1239|Firmicutes,24NIE@186801|Clostridia 186801|Clostridia S oxidoreductase activity - - - - - - - - - - - - - k59_495457_5 400668.Mmwyl1_1915 2.42e-251 714.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1XKXU@135619|Oceanospirillales 135619|Oceanospirillales M COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily - - - - - - - - - - - - Sulfatase k59_495457_6 1205753.A989_01050 1.97e-59 196.0 COG3907@1|root,COG3907@2|Bacteria,1MU4M@1224|Proteobacteria,1S5Z3@1236|Gammaproteobacteria,1X659@135614|Xanthomonadales 135614|Xanthomonadales S PAP2 superfamily - - - - - - - - - - - - PAP2 k59_495457_8 1244869.H261_16236 2.91e-219 611.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2TW6Z@28211|Alphaproteobacteria,2JR08@204441|Rhodospirillales 204441|Rhodospirillales S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - DUF442,Pyr_redox_2 k59_495457_9 1244869.H261_16231 9.26e-34 117.0 COG0425@1|root,COG0425@2|Bacteria,1NDVB@1224|Proteobacteria,2VCAA@28211|Alphaproteobacteria,2JYA8@204441|Rhodospirillales 204441|Rhodospirillales O Sulfurtransferase TusA - - - - - - - - - - - - TusA k59_495457_10 1244869.H261_16226 2.55e-45 150.0 COG2210@1|root,COG2210@2|Bacteria,1NXM5@1224|Proteobacteria 1224|Proteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_495457_11 765912.Thimo_0918 1.3e-20 85.5 2ECSY@1|root,336QI@2|Bacteria,1N9AZ@1224|Proteobacteria,1S9XM@1236|Gammaproteobacteria,1WYWD@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_495457_12 323848.Nmul_A2112 9.74e-49 157.0 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2VUM7@28216|Betaproteobacteria,373AT@32003|Nitrosomonadales 28216|Betaproteobacteria S YCII-related domain yciI - - ko:K09780 - - - - ko00000 - - - YCII k59_495457_13 631362.Thi970DRAFT_03254 5.33e-109 324.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria,1WXKB@135613|Chromatiales 135613|Chromatiales S pfam php - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_495457_14 1049564.TevJSym_ah00760 4.07e-113 328.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1J4HA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the SUA5 family yciO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Sua5_yciO_yrdC k59_495457_15 765913.ThidrDRAFT_3132 4.49e-90 272.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1WWRR@135613|Chromatiales 135613|Chromatiales S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_495457_16 1049564.TevJSym_ah00740 4.55e-243 673.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1J4WF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_495457_17 1249627.D779_0521 4.71e-109 325.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1WW4R@135613|Chromatiales 135613|Chromatiales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_495457_18 1122134.KB893651_gene2199 1.02e-76 243.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1XJRF@135619|Oceanospirillales 135619|Oceanospirillales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_495457_19 1049564.TevJSym_ah00710 1.41e-109 325.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1J4GT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_495457_20 768671.ThimaDRAFT_4255 3.41e-83 254.0 COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria,1WXXG@135613|Chromatiales 135613|Chromatiales L PFAM HhH-GPD - - - ko:K07457 - - - - ko00000 - - - HhH-GPD k59_495457_21 1144319.PMI16_02666 6.17e-31 109.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,474TX@75682|Oxalobacteraceae 28216|Betaproteobacteria K 'Cold-shock' DNA-binding domain cspD2 - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_495457_22 748658.KB907315_gene2650 3.78e-47 153.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1WYBV@135613|Chromatiales 135613|Chromatiales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_495457_23 572477.Alvin_2221 0.0 1060.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales 135613|Chromatiales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_495457_24 283942.IL0673 4.72e-41 135.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,2QGBD@267893|Idiomarinaceae 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_495457_25 765913.ThidrDRAFT_0304 9.05e-83 255.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,1WXDU@135613|Chromatiales 135613|Chromatiales O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_495457_26 395493.BegalDRAFT_1895 1.17e-80 248.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,460CZ@72273|Thiotrichales 72273|Thiotrichales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_495457_27 748247.AZKH_0398 1.49e-23 103.0 COG5581@1|root,COG5581@2|Bacteria,1RJ1B@1224|Proteobacteria,2VTGM@28216|Betaproteobacteria,2KWP1@206389|Rhodocyclales 206389|Rhodocyclales M Flagellar protein YcgR - - - - - - - - - - - - PilZ,YcgR_2 k59_495457_28 1049564.TevJSym_ah00160 1.17e-191 536.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1J4PH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9,4.3.1.9 ko:K00384,ko:K22345 ko00030,ko00450,map00030,map00450 - R01544,R02016,R03596,R09372 RC00013,RC00544,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_495457_29 1049564.TevJSym_ah00180 0.0 917.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1J4IX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_495457_30 325777.GW15_0209125 4.04e-28 112.0 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1X5BW@135614|Xanthomonadales 135614|Xanthomonadales M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_495457_31 1049564.TevJSym_ah00200 6.05e-228 638.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1J4TM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L ATPase related to the helicase subunit of the Holliday junction resolvase rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_495457_32 1049564.TevJSym_ah00210 1.22e-53 171.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1J6UX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_495457_33 1049564.TevJSym_ah00220 3.53e-42 140.0 COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 k59_495457_34 765910.MARPU_08835 3.08e-225 630.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_495457_36 1049564.TevJSym_ah00250 1.37e-94 282.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1JA0E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Inhibitor of apoptosis-promoting Bax1 yccA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0019222,GO:0030162,GO:0031224,GO:0044425,GO:0044464,GO:0050789,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071944,GO:0080090 - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_1018403_1 379731.PST_1072 3.15e-60 196.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1Z1U6@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_463871_1 667632.KB890187_gene3102 1.59e-89 276.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,1JZMM@119060|Burkholderiaceae 28216|Betaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_756749_1 1168034.FH5T_00005 5.83e-192 541.0 COG0593@1|root,COG0593@2|Bacteria,4NE6Q@976|Bacteroidetes,2FNPD@200643|Bacteroidia 976|Bacteroidetes L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_397727_1 765911.Thivi_0273 3.62e-63 216.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales 135613|Chromatiales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_299284_1 999423.HMPREF9161_01353 2.52e-54 184.0 COG0438@1|root,COG0438@2|Bacteria,1TQN3@1239|Firmicutes,4H694@909932|Negativicutes 909932|Negativicutes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_104068_1 502025.Hoch_2126 9.24e-99 306.0 COG2866@1|root,COG2866@2|Bacteria,1R586@1224|Proteobacteria,433ZT@68525|delta/epsilon subdivisions,2X4AT@28221|Deltaproteobacteria,2YYMP@29|Myxococcales 28221|Deltaproteobacteria E Zn_pept - - - - - - - - - - - - Peptidase_M14 k59_201484_1 1056816.JAFQ01000004_gene6926 8.8e-10 64.7 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4G6J4@85025|Nocardiaceae 201174|Actinobacteria Q Condensation domain - - - - - - - - - - - - ACP_syn_III,ACP_syn_III_C,AMP-binding,AMP-binding_C,Condensation,MFS_1,PP-binding,Thioesterase k59_234445_1 563040.Saut_0538 4.28e-74 234.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2YMJW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N k59_887414_1 642492.Clole_2855 3.15e-103 315.0 COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia 186801|Clostridia E Belongs to the alpha-IPM synthase homocitrate synthase family leuA3 - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_953327_2 318464.IO99_09930 4.23e-11 63.5 COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,36MV2@31979|Clostridiaceae 186801|Clostridia L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_986066_1 749222.Nitsa_0862 3.39e-43 158.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2YN2C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT,HD_4,RelA_SpoT,TGS k59_986066_2 553219.CAMSH0001_2286 1.51e-20 83.6 COG1758@1|root,COG1758@2|Bacteria,1Q28G@1224|Proteobacteria,42V5Z@68525|delta/epsilon subdivisions,2YQDH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_299289_1 1209072.ALBT01000031_gene1859 7.57e-37 134.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1FG6Q@10|Cellvibrio 1236|Gammaproteobacteria K ParB-like nuclease domain parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_299289_2 1122603.ATVI01000006_gene49 1.07e-38 137.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1X30T@135614|Xanthomonadales 135614|Xanthomonadales D chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_37826_1 307480.IW16_18435 2.44e-64 206.0 COG2227@1|root,COG2227@2|Bacteria,4NJ5M@976|Bacteroidetes,1I10P@117743|Flavobacteriia,3ZPD9@59732|Chryseobacterium 976|Bacteroidetes H Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,TehB k59_429877_1 395493.BegalDRAFT_1115 7.86e-83 280.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_3578_1 335543.Sfum_2525 2.7e-75 240.0 COG0568@1|root,COG0568@2|Bacteria,1MXGX@1224|Proteobacteria,42PIS@68525|delta/epsilon subdivisions,2WKSS@28221|Deltaproteobacteria,2MQYD@213462|Syntrophobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_855546_1 95619.PM1_0216345 3.65e-73 230.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_855546_2 876044.IMCC3088_1328 1.47e-100 300.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,1J6JA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_855546_3 1415778.JQMM01000001_gene851 1.86e-118 352.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1J5A7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_2215 Thiolase_C,Thiolase_N k59_953338_1 1249627.D779_0852 2.59e-56 196.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales 135613|Chromatiales U type IV pilus secretin PilQ - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_496089_1 1120965.AUBV01000009_gene3118 3.14e-69 223.0 COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,47KQS@768503|Cytophagia 976|Bacteroidetes M membrane protein involved in D-alanine export - - - - - - - - - - - - MBOAT k59_332884_2 498761.HM1_0291 5.34e-07 52.0 COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia 186801|Clostridia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_332890_1 1165841.SULAR_07460 2.23e-101 305.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,42MQ3@68525|delta/epsilon subdivisions,2YMPC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_463905_1 1168034.FH5T_12875 2.99e-120 344.0 COG0094@1|root,COG0094@2|Bacteria,4NEGY@976|Bacteroidetes,2FM5Y@200643|Bacteroidia 976|Bacteroidetes J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_463905_2 997884.HMPREF1068_04069 1.26e-39 132.0 COG0199@1|root,COG0199@2|Bacteria,4NQ6N@976|Bacteroidetes,2FTD0@200643|Bacteroidia,4AQZ4@815|Bacteroidaceae 976|Bacteroidetes J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_299302_1 396588.Tgr7_0842 1.36e-113 340.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales 135613|Chromatiales P CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_561674_1 1384056.N787_14090 4.07e-09 59.7 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1X3UJ@135614|Xanthomonadales 135614|Xanthomonadales D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_561674_2 1384056.N787_14085 7.32e-58 186.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1X4HD@135614|Xanthomonadales 135614|Xanthomonadales D cell division ATP-binding protein FtsE ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_1019009_1 1168034.FH5T_14375 5.45e-84 268.0 COG3307@1|root,COG3307@2|Bacteria 2|Bacteria M -O-antigen - - - ko:K16705 - - - - ko00000 - - - Wzy_C k59_201517_1 1121127.JAFA01000013_gene2297 1.16e-72 230.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,1K3C4@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_429894_1 754476.Q7A_248 6.5e-65 209.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,461TR@72273|Thiotrichales 72273|Thiotrichales S Lysin motif - - - - - - - - - - - - LysM k59_136929_1 435591.BDI_2310 4.39e-74 248.0 COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,2FKYY@200643|Bacteroidia,22X50@171551|Porphyromonadaceae 976|Bacteroidetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,TonB_dep_Rec k59_104125_1 313606.M23134_08248 1.07e-11 75.1 COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,47N72@768503|Cytophagia 976|Bacteroidetes K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - ANAPC3,Guanylate_cyc,HTH_18,TPR_8 k59_953346_1 1288826.MSNKSG1_04046 4.31e-38 133.0 2DC7W@1|root,2ZD7C@2|Bacteria,1QU8S@1224|Proteobacteria,1S6MA@1236|Gammaproteobacteria,46BPC@72275|Alteromonadaceae 1236|Gammaproteobacteria S Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_953346_3 387092.NIS_0370 2.93e-127 369.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2YMER@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_953346_4 1165841.SULAR_07123 1.13e-111 333.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2YNID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S acid membrane antigen A amaA - - - - - - - - - - - AI-2E_transport k59_921359_1 765911.Thivi_1064 8.89e-45 165.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_756809_1 553220.CAMGR0001_0727 1.06e-34 132.0 COG0614@1|root,COG0614@2|Bacteria,1NVK4@1224|Proteobacteria,42MBT@68525|delta/epsilon subdivisions,2YMTN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_822961_1 1120988.AXWV01000106_gene1731 8.23e-46 162.0 2E5W0@1|root,330K2@2|Bacteria,1NAEG@1224|Proteobacteria,1SSAN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4433) - - - - - - - - - - - - DUF4433 k59_822961_2 1137269.AZWL01000022_gene3528 1.18e-12 68.2 COG0210@1|root,COG0210@2|Bacteria 2|Bacteria L ATP-dependent DNA helicase activity - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C k59_299319_1 439235.Dalk_0092 7.74e-55 196.0 COG1413@1|root,COG2199@1|root,COG3899@1|root,COG1413@2|Bacteria,COG2199@2|Bacteria,COG3899@2|Bacteria 2|Bacteria T PFAM Protein kinase domain cpeY - 2.7.11.1,2.7.7.65 ko:K05385,ko:K12132,ko:K13590 ko00196,ko01100,ko04112,map00196,map01100,map04112 - - - ko00000,ko00001,ko00194,ko01000,ko01001 - - - AAA_16,EAL,GGDEF,Trans_reg_C k59_70931_1 1454007.JAUG01000098_gene1475 6.37e-16 83.2 COG1361@1|root,COG2374@1|root,COG3121@1|root,COG3209@1|root,COG1361@2|Bacteria,COG2374@2|Bacteria,COG3121@2|Bacteria,COG3209@2|Bacteria,4NG16@976|Bacteroidetes,1ITFW@117747|Sphingobacteriia 976|Bacteroidetes M Domains in Na-Ca exchangers and integrin-beta4 - - - - - - - - - - - - CHU_C,Calx-beta,DUF11 k59_986111_1 572544.Ilyop_1385 4.17e-33 119.0 COG2172@1|root,COG2172@2|Bacteria,37A5Z@32066|Fusobacteria 32066|Fusobacteria T Histidine kinase-like ATPase domain - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 k59_986111_2 572544.Ilyop_1384 1.51e-54 172.0 COG1366@1|root,COG1366@2|Bacteria,37AEP@32066|Fusobacteria 32066|Fusobacteria T STAS domain - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS k59_986111_3 572544.Ilyop_1383 1.03e-207 594.0 COG1418@1|root,COG1418@2|Bacteria,378HY@32066|Fusobacteria 32066|Fusobacteria D Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_266596_1 1168034.FH5T_12270 2.98e-129 374.0 COG0167@1|root,COG0167@2|Bacteria,4NJVM@976|Bacteroidetes,2FR3A@200643|Bacteroidia 976|Bacteroidetes F Dihydroorotate dehydrogenase - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_136947_1 1123073.KB899241_gene2140 4.48e-42 149.0 COG0189@1|root,COG0189@2|Bacteria,1MV29@1224|Proteobacteria,1SB70@1236|Gammaproteobacteria,1X81A@135614|Xanthomonadales 135614|Xanthomonadales HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - - - - - - - - - - - k59_953356_1 1168034.FH5T_05660 9.4e-09 54.7 COG1704@1|root,COG1704@2|Bacteria,4NMD3@976|Bacteroidetes,2FNPV@200643|Bacteroidia 976|Bacteroidetes S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_953356_2 1338011.BD94_1366 4.3e-203 580.0 COG2987@1|root,COG2987@2|Bacteria,4NF2P@976|Bacteroidetes,1HXQQ@117743|Flavobacteriia,34Q9P@308865|Elizabethkingia 976|Bacteroidetes E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_822973_1 987059.RBXJA2T_18824 0.000586 48.9 COG0642@1|root,COG0784@1|root,COG2197@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2197@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,1KPMM@119065|unclassified Burkholderiales 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_626628_1 1121423.JONT01000001_gene1843 6.37e-17 86.7 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,NAD_binding_8,Pyr_redox_2 k59_37872_1 340.xcc-b100_1526 1.07e-32 129.0 COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,1RP0R@1236|Gammaproteobacteria,1X55T@135614|Xanthomonadales 135614|Xanthomonadales V Beta-lactamase ampC2 - - - - - - - - - - - Beta-lactamase,DUF3471 k59_234501_1 709032.Sulku_1372 2.24e-75 228.0 COG2406@1|root,COG2406@2|Bacteria,1RE25@1224|Proteobacteria,42PJ1@68525|delta/epsilon subdivisions,2YMUJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ferritin - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_234501_2 1565314.OA34_03695 4.09e-57 182.0 COG1592@1|root,COG1592@2|Bacteria,1RC1F@1224|Proteobacteria,43BFI@68525|delta/epsilon subdivisions,2YN12@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Rubrerythrin rrc - - - - - - - - - - - Desulfoferrod_N,Rubrerythrin k59_266602_1 1123519.PSJM300_14515 2.12e-15 75.5 2DKZI@1|root,310D6@2|Bacteria,1QV1U@1224|Proteobacteria,1T269@1236|Gammaproteobacteria,1Z4F8@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S E3 Ubiquitin ligase - - - - - - - - - - - - GIDE k59_266602_2 1245471.PCA10_46850 3.56e-77 236.0 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,1YDPY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_626633_1 768671.ThimaDRAFT_2715 1.52e-84 257.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1WWCV@135613|Chromatiales 135613|Chromatiales E Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_724569_1 1168034.FH5T_22065 7.8e-146 425.0 COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,2FNIS@200643|Bacteroidia 976|Bacteroidetes S ATP-binding cassette protein, ChvD family - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_Xtn k59_397806_1 908937.Prede_0821 2.88e-113 338.0 COG0541@1|root,COG0541@2|Bacteria,4NDZ2@976|Bacteroidetes,2FNSI@200643|Bacteroidia 976|Bacteroidetes U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_397806_2 1168034.FH5T_01110 1.26e-104 308.0 COG0190@1|root,COG0190@2|Bacteria,4NEJP@976|Bacteroidetes,2FMNT@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_299337_2 929558.SMGD1_1261 7.01e-100 292.0 COG2128@1|root,COG2128@2|Bacteria,1PZ9M@1224|Proteobacteria,42PYF@68525|delta/epsilon subdivisions,2YNK8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_953370_1 218491.ECA2825 2.32e-27 109.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1MPYT@122277|Pectobacterium 1236|Gammaproteobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z0994 BATS,Radical_SAM k59_332945_1 1121396.KB893057_gene2445 2.78e-84 266.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_529190_1 748247.AZKH_2904 1.46e-92 296.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VMWP@28216|Betaproteobacteria,2KVYZ@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family padB - 1.17.5.1,3.1.2.25 ko:K18361 ko00360,map00360 - R07222,R07294 RC00004,RC01844,RC01903 ko00000,ko00001,ko01000 - - - Molybdopterin,Molydop_binding k59_593585_1 435591.BDI_2610 2.51e-96 295.0 COG3119@1|root,COG3119@2|Bacteria,4NJ83@976|Bacteroidetes,2FM83@200643|Bacteroidia,22XH2@171551|Porphyromonadaceae 976|Bacteroidetes P Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - DUF4976,Sulfatase k59_266608_1 190304.FN0717 2.02e-31 117.0 COG1187@1|root,COG1187@2|Bacteria,3791T@32066|Fusobacteria 32066|Fusobacteria J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_266608_2 572544.Ilyop_0934 7.71e-54 177.0 COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,37909@32066|Fusobacteria 32066|Fusobacteria M Peptidase, M23 - - - - - - - - - - - - LysM,Peptidase_M23 k59_234521_1 95619.PM1_0224205 1.42e-10 61.2 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0276 family - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_234521_2 1384056.N787_05280 3.56e-49 165.0 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1X658@135614|Xanthomonadales 135614|Xanthomonadales S Putative DNA-binding domain - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_855621_1 1267533.KB906737_gene1664 2.23e-33 119.0 COG3628@1|root,COG3628@2|Bacteria,3Y5FV@57723|Acidobacteria,2JJYH@204432|Acidobacteriia 204432|Acidobacteriia S Gene 25-like lysozyme - - - ko:K06903 - - - - ko00000 - - - GPW_gp25 k59_626651_1 400682.PAC_15700837 1.71e-11 63.9 COG0053@1|root,KOG1485@2759|Eukaryota,39UQ6@33154|Opisthokonta,3BV26@33208|Metazoa 33208|Metazoa P Dimerisation domain of Zinc Transporter - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_496167_1 1168034.FH5T_01620 1.17e-47 159.0 COG0509@1|root,COG0509@2|Bacteria 2|Bacteria E glycine decarboxylation via glycine cleavage system gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H,Response_reg k59_496167_2 1168034.FH5T_01625 3.49e-58 192.0 COG5557@1|root,COG5557@2|Bacteria 2|Bacteria C Polysulphide reductase, NrfD hmcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - NrfD k59_136986_1 1121459.AQXE01000012_gene2298 6.05e-87 267.0 COG3842@1|root,COG3842@2|Bacteria,1QU06@1224|Proteobacteria,43BT4@68525|delta/epsilon subdivisions,2X73U@28221|Deltaproteobacteria,2M9YN@213115|Desulfovibrionales 28221|Deltaproteobacteria P ATPases associated with a variety of cellular activities - - - ko:K17324 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - ABC_tran k59_529199_1 323848.Nmul_A1098 2.51e-57 190.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,371TY@32003|Nitrosomonadales 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_529199_2 1031711.RSPO_c01378 3.45e-09 58.9 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,1JZXQ@119060|Burkholderiaceae 28216|Betaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_659932_1 1168034.FH5T_08575 9.32e-114 358.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,2FP1Q@200643|Bacteroidia 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_529200_2 436114.SYO3AOP1_1745 7.21e-05 45.4 COG1459@1|root,COG1459@2|Bacteria,2G3MI@200783|Aquificae 200783|Aquificae NU Type II secretion system pilC1 - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_169786_1 713586.KB900536_gene534 8.06e-81 268.0 COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria,1SWBY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_562200_1 933262.AXAM01000013_gene1292 2.63e-82 255.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2MHV9@213118|Desulfobacterales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_757334_1 944547.ABLL_1482 1.47e-76 238.0 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2YN7B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_986637_1 1408439.JHXW01000002_gene781 2.02e-24 101.0 COG0635@1|root,COG0635@2|Bacteria,378ZR@32066|Fusobacteria 32066|Fusobacteria H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - Radical_SAM k59_986637_2 572544.Ilyop_0255 5.58e-284 791.0 COG1109@1|root,COG1109@2|Bacteria,37840@32066|Fusobacteria 32066|Fusobacteria G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II pgcA - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_986637_3 469618.FVAG_00324 2.68e-32 122.0 COG2984@1|root,COG2984@2|Bacteria,37AA2@32066|Fusobacteria 32066|Fusobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_921865_1 572544.Ilyop_0752 4.79e-183 533.0 COG0383@1|root,COG0383@2|Bacteria,3798P@32066|Fusobacteria 32066|Fusobacteria G hydrolase family 38 - - 3.2.1.170 ko:K15524 - - - - ko00000,ko01000 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C k59_692535_1 1203554.HMPREF1476_01834 2.34e-128 371.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,4PQCI@995019|Sutterellaceae 28216|Betaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_71488_1 1101195.Meth11DRAFT_1222 9.54e-54 181.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,2KMA0@206350|Nitrosomonadales 206350|Nitrosomonadales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_823399_1 365044.Pnap_2655 1.07e-50 167.0 COG1675@1|root,COG1675@2|Bacteria,1MZ5R@1224|Proteobacteria,2VV6V@28216|Betaproteobacteria,4AFRE@80864|Comamonadaceae 28216|Betaproteobacteria K transcription initiation from RNA polymerase II promoter - - - - - - - - - - - - - k59_986642_1 1165841.SULAR_01345 1.73e-243 696.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2YMFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_856060_1 521719.ATXQ01000009_gene905 1.41e-37 129.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1YFTK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria KT Response regulator receiver domain pilG - - ko:K02657,ko:K03413 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_856060_2 85643.Tmz1t_3689 1.41e-40 137.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,2KWTI@206389|Rhodocyclales 206389|Rhodocyclales T response regulator receiver pilH - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_430353_1 1380387.JADM01000002_gene2223 1.11e-102 314.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1XHHE@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase ntrB - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8 k59_398253_1 443144.GM21_2073 8.41e-47 158.0 COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,43UMS@69541|Desulfuromonadales 28221|Deltaproteobacteria S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_856070_1 441768.ACL_0803 4.95e-43 167.0 COG0474@1|root,COG0474@2|Bacteria,3WSUP@544448|Tenericutes 544448|Tenericutes P P-type ATPase ctp GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_464387_1 768671.ThimaDRAFT_2724 2.15e-30 113.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1WW0F@135613|Chromatiales 135613|Chromatiales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_464387_2 305700.B447_02096 1.33e-36 137.0 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,2KUHY@206389|Rhodocyclales 206389|Rhodocyclales T COG0631 Serine threonine protein phosphatase - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_887972_1 1357400.HMPREF2086_00359 1.2e-46 166.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2YMS0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_365897_1 1168034.FH5T_19530 2.37e-46 169.0 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,2FNBJ@200643|Bacteroidia 976|Bacteroidetes S Psort location OuterMembrane, score 9.49 - - - - - - - - - - - - TamB k59_234964_1 1266909.AUAG01000010_gene2671 4.33e-86 260.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales 135613|Chromatiales L Belongs to the UPF0758 family - - - ko:K03630 - - - - ko00000 - - - RadC k59_267051_2 887062.HGR_05429 2.88e-107 318.0 COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,2VQHY@28216|Betaproteobacteria,4ADH5@80864|Comamonadaceae 28216|Betaproteobacteria S 3-oxo-5-alpha-steroid 4-dehydrogenase - - - - - - - - - - - - DUF1295 k59_267051_3 247633.GP2143_09250 7.38e-14 71.2 COG4338@1|root,COG4338@2|Bacteria,1PM12@1224|Proteobacteria,1TH8G@1236|Gammaproteobacteria,1JB3I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_529697_1 1223410.KN050846_gene1575 8.64e-109 327.0 COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes,1HYW1@117743|Flavobacteriia 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1019490_1 1278308.KB907078_gene2068 1.12e-22 105.0 COG3408@1|root,COG3979@1|root,COG3408@2|Bacteria,COG3979@2|Bacteria,2H2QX@201174|Actinobacteria 201174|Actinobacteria G Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_170219_1 1168034.FH5T_00280 3.3e-168 478.0 COG3288@1|root,COG3288@2|Bacteria,4NGH1@976|Bacteroidetes,2G2N7@200643|Bacteroidia 976|Bacteroidetes C NAD(P)( ) transhydrogenase (AB-specific), alpha subunit pntAA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_887976_1 1121396.KB893053_gene2383 1.2e-107 321.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2MISV@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_823421_1 546262.NEICINOT_03162 3.65e-08 55.1 28RFF@1|root,2ZDUK@2|Bacteria,1PAVW@1224|Proteobacteria,2W54F@28216|Betaproteobacteria,2KTJK@206351|Neisseriales 206351|Neisseriales - - - - - - - - - - - - - - - k59_104670_1 572544.Ilyop_0116 6.99e-135 387.0 COG2084@1|root,COG2084@2|Bacteria,37A7W@32066|Fusobacteria 32066|Fusobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.291 ko:K19647 ko00760,ko01120,map00760,map01120 - R07985 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_823423_1 143224.JQMD01000002_gene1168 1.37e-90 278.0 COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,1HZCR@117743|Flavobacteriia 976|Bacteroidetes G Converts alpha-aldose to the beta-anomer - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_3947_1 1168034.FH5T_08575 7.36e-81 266.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,2FP1Q@200643|Bacteroidia 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_725063_1 1156919.QWC_24005 2.08e-35 128.0 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VJ6G@28216|Betaproteobacteria,3T3D2@506|Alcaligenaceae 28216|Betaproteobacteria S Carboxylesterase estB - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_71554_1 272624.lpg2618 5.15e-42 153.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1JC9H@118969|Legionellales 118969|Legionellales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_398288_1 1123508.JH636441_gene3046 5.82e-39 147.0 COG3118@1|root,COG3118@2|Bacteria,2J53R@203682|Planctomycetes 203682|Planctomycetes O PFAM ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_594119_1 485918.Cpin_0142 4.89e-19 93.6 COG0457@1|root,COG0457@2|Bacteria,4NGID@976|Bacteroidetes,1IXMZ@117747|Sphingobacteriia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - - k59_430397_1 713587.THITH_10595 4.39e-93 278.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1S1ME@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein frdB - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_398290_1 489825.LYNGBM3L_32080 1.6e-10 61.6 COG0642@1|root,COG2203@1|root,COG4251@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1H9XM@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_398290_2 1173025.GEI7407_1904 6.18e-09 61.6 COG2202@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,1H8X5@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9 k59_267081_1 754436.JCM19237_5656 5.59e-33 122.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1XT4A@135623|Vibrionales 135623|Vibrionales G in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_267081_2 929506.CbC4_1951 1.13e-59 196.0 COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia,36W7D@31979|Clostridiaceae 186801|Clostridia G Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP) iolC - 2.7.1.4,2.7.1.92 ko:K00847,ko:K03338 ko00051,ko00500,ko00520,ko00562,ko01100,ko01120,map00051,map00500,map00520,map00562,map01100,map01120 - R00760,R00867,R03920,R05661 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_953842_2 1123399.AQVE01000004_gene2574 5.27e-25 102.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,460VX@72273|Thiotrichales 72273|Thiotrichales S Carbon-nitrogen hydrolase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_299829_1 387093.SUN_0030 7.41e-52 183.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2YNRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU general secretion pathway protein D - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_986700_1 1168289.AJKI01000012_gene306 9.28e-11 62.4 COG0399@1|root,COG0399@2|Bacteria,4NEBI@976|Bacteroidetes,2FPAJ@200643|Bacteroidia,3XJ34@558415|Marinilabiliaceae 976|Bacteroidetes M DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_986700_2 411154.GFO_2034 1.53e-124 367.0 COG0673@1|root,COG0673@2|Bacteria,4NE07@976|Bacteroidetes,1I4PA@117743|Flavobacteriia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold gfo_1 - 1.1.1.384 ko:K13327 ko00523,ko01130,map00523,map01130 M00801,M00802 R05526 RC00897 ko00000,ko00001,ko00002,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_986700_3 1123517.JOMR01000001_gene1333 1.54e-267 741.0 2CCXX@1|root,2Z8MY@2|Bacteria,1RE6D@1224|Proteobacteria 1224|Proteobacteria S PFAM NDP-hexose 23-dehydratase - - 4.2.1.159 ko:K16435 ko00523,ko01055,ko01130,map00523,map01055,map01130 M00798,M00799,M00800,M00801,M00802,M00803 R05518,R06428 RC00782,RC01448 ko00000,ko00001,ko00002,ko01000 - - - Hexose_dehydrat k59_986700_5 1172190.M947_08530 8e-08 52.4 COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,42M12@68525|delta/epsilon subdivisions,2YNBD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_856126_1 203122.Sde_3100 1.63e-42 149.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,466CP@72275|Alteromonadaceae 1236|Gammaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_856126_2 395493.BegalDRAFT_2644 3.08e-92 283.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,46043@72273|Thiotrichales 72273|Thiotrichales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_430406_1 1123261.AXDW01000001_gene1446 3.38e-42 153.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1X2ZV@135614|Xanthomonadales 135614|Xanthomonadales M Lipoprotein releasing system transmembrane protein lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_660451_1 765912.Thimo_3426 4.49e-81 256.0 COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,1T1PS@1236|Gammaproteobacteria,1WVXX@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_660451_2 338966.Ppro_2228 2.23e-52 171.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42QPB@68525|delta/epsilon subdivisions,2WMP0@28221|Deltaproteobacteria,43T71@69541|Desulfuromonadales 28221|Deltaproteobacteria K response regulator - - - ko:K07664 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_464430_1 1168034.FH5T_18820 1.79e-62 213.0 COG2887@1|root,COG2887@2|Bacteria,4NFZQ@976|Bacteroidetes,2FN03@200643|Bacteroidia 976|Bacteroidetes L DNA-dependent ATPase I and helicase II - - - - - - - - - - - - PDDEXK_1 k59_137600_2 454957.IA64_19055 4.91e-51 170.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1X3CE@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_202112_1 439235.Dalk_2561 1.6e-36 131.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Methylenetetrahydrofolate reductase metF-1 - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_333570_1 1499689.CCNN01000007_gene2562 5.35e-36 142.0 COG4412@1|root,COG4412@2|Bacteria,1UIJ6@1239|Firmicutes,24BZI@186801|Clostridia,36HGY@31979|Clostridiaceae 186801|Clostridia G M6 family metalloprotease domain protein - - - - - - - - - - - - Big_4,CW_binding_1,F5_F8_type_C,Laminin_G_3 k59_430407_1 177437.HRM2_40720 4.43e-126 370.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2MID8@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM cytochrome bd ubiquinol oxidase subunit I cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_986707_1 1231190.NA8A_18497 1.26e-55 193.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,43H44@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_725082_1 3702.ATCG00190.1 0.0 1013.0 COG0085@1|root,KOG0214@2759|Eukaryota,37HVP@33090|Viridiplantae,3G72V@35493|Streptophyta,3I0YM@3699|Brassicales 35493|Streptophyta K rna polymerase rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_921929_1 323261.Noc_2249 2.62e-128 382.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_170261_1 526218.Sterm_3781 2.98e-18 83.6 COG1454@1|root,COG1454@2|Bacteria,3792I@32066|Fusobacteria 2|Bacteria C PFAM Iron-containing alcohol dehydrogenase - - 1.1.99.37,1.2.98.1 ko:K17067 ko00625,ko00680,ko01120,ko01200,map00625,map00680,map01120,map01200 - R00614 RC00034,RC00188 ko00000,ko00001,ko01000 - - - Fe-ADH k59_170261_2 316407.85676158 2.02e-52 166.0 COG3254@1|root,COG3254@2|Bacteria,1RGYV@1224|Proteobacteria,1S6AI@1236|Gammaproteobacteria,3XPXF@561|Escherichia 1236|Gammaproteobacteria G Involved in the anomeric conversion of L-rhamnose rhaM GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.1.3.32 ko:K03534 - - R10819 RC00563 ko00000,ko01000 - - - rhaM k59_170261_3 1414720.CBYM010000020_gene2487 4.78e-153 434.0 COG0235@1|root,COG0235@2|Bacteria,1TRMG@1239|Firmicutes,24BBT@186801|Clostridia,36DP6@31979|Clostridiaceae 186801|Clostridia G Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde rhaD - 4.1.2.19 ko:K01629 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01785,R02263 RC00438,RC00599,RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II k59_170261_4 536227.CcarbDRAFT_0390 1.06e-52 177.0 COG4806@1|root,COG4806@2|Bacteria,1TS42@1239|Firmicutes,2487G@186801|Clostridia,36HH0@31979|Clostridiaceae 186801|Clostridia G Belongs to the rhamnose isomerase family rhaA - 5.3.1.14 ko:K01813 ko00051,ko01120,map00051,map01120 - R02437 RC00434 ko00000,ko00001,ko01000 - - - RhaA k59_888029_1 290400.Jann_3107 2.29e-23 94.7 COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,2U7CA@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG1136 ABC-type antimicrobial peptide transport system ATPase component - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_137607_1 765914.ThisiDRAFT_2401 2.21e-10 63.2 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales 135613|Chromatiales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_137607_2 159087.Daro_3453 1.11e-16 80.9 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,2VI8F@28216|Betaproteobacteria,2KW3F@206389|Rhodocyclales 206389|Rhodocyclales M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_529765_1 1449050.JNLE01000003_gene3355 2.8e-101 299.0 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,24DGQ@186801|Clostridia,36E9G@31979|Clostridiaceae 186801|Clostridia L PFAM Integrase catalytic region - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_496762_1 1380391.JIAS01000014_gene1946 9.16e-51 186.0 COG0318@1|root,COG0477@1|root,COG0318@2|Bacteria,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TRA4@28211|Alphaproteobacteria,2JPPF@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_953861_1 1304275.C41B8_10410 6.61e-229 658.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_888041_1 1279019.ARQK01000031_gene1201 1.05e-16 82.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales 135613|Chromatiales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_888041_2 1123326.JFBL01000020_gene2663 3.53e-30 114.0 COG1752@1|root,COG1752@2|Bacteria,1PDTM@1224|Proteobacteria,42SDA@68525|delta/epsilon subdivisions,2YPIV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_430426_1 1249480.B649_11060 4.9e-52 171.0 COG0546@1|root,COG0546@2|Bacteria,1RBMZ@1224|Proteobacteria,42RG3@68525|delta/epsilon subdivisions,2YP44@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hydrolase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_430426_2 1537917.JU82_01995 8.31e-44 146.0 COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2YN1Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C pyruvate ferredoxin oxidoreductase porC - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_562304_1 1122929.KB908217_gene276 8.31e-53 179.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_660485_1 521674.Plim_1862 0.000148 45.1 COG1560@1|root,COG1560@2|Bacteria,2IY7N@203682|Planctomycetes 203682|Planctomycetes M Lipid A biosynthesis acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_170712_1 1168034.FH5T_08530 1.3e-146 425.0 COG2211@1|root,COG2211@2|Bacteria,4NE3F@976|Bacteroidetes,2FMUY@200643|Bacteroidia 976|Bacteroidetes G Transporter, major facilitator family protein - - - ko:K16211 - - - - ko00000,ko02000 2.A.2.6 - - MFS_1 k59_202672_1 1408442.JADE01000008_gene67 1.8e-56 186.0 COG2356@1|root,COG2356@2|Bacteria,1MXQM@1224|Proteobacteria,434AE@68525|delta/epsilon subdivisions,2YS18@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Endonuclease I - - 3.1.21.1 ko:K01150 - - - - ko00000,ko01000 - - - Endonuclease_1 k59_594767_1 616991.JPOO01000001_gene3745 1.61e-84 259.0 COG0332@1|root,COG0332@2|Bacteria,4NE5Q@976|Bacteroidetes,1HXY8@117743|Flavobacteriia 976|Bacteroidetes I this condensing enzyme differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs darB - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III_C,Thiolase_N,ketoacyl-synt k59_888561_1 1168034.FH5T_01895 2.81e-197 582.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,4NETY@976|Bacteroidetes,2FM2Z@200643|Bacteroidia 976|Bacteroidetes F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_170717_1 90814.KL370891_gene1383 2.78e-15 80.9 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,4609X@72273|Thiotrichales 72273|Thiotrichales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_823895_1 525898.Sdel_1232 1.58e-44 165.0 COG0666@1|root,COG5276@1|root,COG0666@2|Bacteria,COG5276@2|Bacteria,1R46A@1224|Proteobacteria 1224|Proteobacteria S LVIVD repeat - - - - - - - - - - - - Big_5,LVIVD k59_38538_2 706433.HMPREF9430_00899 3.14e-07 56.6 COG0531@1|root,COG0531@2|Bacteria,1TQ48@1239|Firmicutes 1239|Firmicutes E amino acid frlA - - ko:K19540 - - - - ko00000,ko02000 2.A.3.8.17 - - AA_permease_2 k59_594779_1 1537917.JU82_10320 9.59e-88 263.0 COG0564@1|root,COG0564@2|Bacteria,1RDAG@1224|Proteobacteria,42SR2@68525|delta/epsilon subdivisions 1224|Proteobacteria J Pseudouridine synthase Z012_05060 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.24,5.4.99.28,5.4.99.29 ko:K06177,ko:K06179,ko:K06180 - - - - ko00000,ko01000,ko03009,ko03016 - - - PseudoU_synth_2 k59_366496_2 323261.Noc_A0005 1.34e-49 172.0 COG0758@1|root,COG0758@2|Bacteria 2|Bacteria LU DNA mediated transformation smf - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_137996_1 326298.Suden_1708 5.7e-68 226.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,42UFD@68525|delta/epsilon subdivisions,2YTRP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L SapC - - - ko:K07491 - - - - ko00000 - - - SapC,Y1_Tnp k59_856636_1 387093.SUN_2047 4.36e-114 334.0 COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,42PCG@68525|delta/epsilon subdivisions,2YN6X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S metallophosphoesterase - - - ko:K09769 - - - - ko00000 - - - YmdB k59_464845_1 382464.ABSI01000011_gene2323 2.64e-157 474.0 COG3696@1|root,COG3696@2|Bacteria,46USJ@74201|Verrucomicrobia 2|Bacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_530147_1 760192.Halhy_1759 1.21e-37 140.0 COG1073@1|root,COG1073@2|Bacteria,4NI6C@976|Bacteroidetes,1INXP@117747|Sphingobacteriia 976|Bacteroidetes S Acetyl xylan esterase - - - - - - - - - - - - AXE1 k59_627838_1 1049564.TevJSym_ak00380 1.31e-143 426.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1J572@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Oligopeptidase A prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_1019952_1 1121285.AUFK01000018_gene565 2.45e-14 70.5 COG1515@1|root,COG1515@2|Bacteria,4NQD8@976|Bacteroidetes,1I225@117743|Flavobacteriia,3ZRRX@59732|Chryseobacterium 976|Bacteroidetes L Endonuclease V recD - 3.1.11.5,3.1.21.7 ko:K01144,ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_1019952_2 880073.Calab_2486 1.1e-183 520.0 COG0205@1|root,COG0205@2|Bacteria,2NNY2@2323|unclassified Bacteria 2|Bacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - iJN678.pfkA PFK k59_334182_1 1517416.IDAT_09195 2.54e-22 100.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,2QF26@267893|Idiomarinaceae 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_856647_1 96561.Dole_1015 8.73e-48 164.0 COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,42SPY@68525|delta/epsilon subdivisions,2WP3D@28221|Deltaproteobacteria,2MPV3@213118|Desulfobacterales 28221|Deltaproteobacteria Q PFAM Mammalian cell entry related domain protein - - - ko:K02067,ko:K06192 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_562793_5 1378168.N510_01602 5.22e-05 50.4 COG1879@1|root,COG1879@2|Bacteria,1TQW5@1239|Firmicutes 1239|Firmicutes G ABC-type sugar transport system periplasmic component - - - ko:K10540 ko02010,ko02030,map02010,map02030 M00214 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.3 - - Peripla_BP_4 k59_693093_1 1286632.P278_00750 3.6e-101 301.0 COG3669@1|root,COG3669@2|Bacteria,4NHZ4@976|Bacteroidetes 976|Bacteroidetes G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos k59_693093_2 709991.Odosp_0616 6.35e-12 67.8 COG0526@1|root,COG0526@2|Bacteria,4NZUY@976|Bacteroidetes,2FX6W@200643|Bacteroidia 976|Bacteroidetes CO Thioredoxin - - - - - - - - - - - - - k59_987327_1 1517416.IDAT_10045 3.16e-68 228.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RXWZ@1236|Gammaproteobacteria,2QGUV@267893|Idiomarinaceae 1236|Gammaproteobacteria EU alpha/beta hydrolase fold - - - - - - - - - - - - Peptidase_S9 k59_562794_1 642227.HA49_04210 0.000212 43.5 COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,1RQMB@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Protein of unknown function DUF111 - - - - - - - - - - - - DUF111 k59_562794_2 156889.Mmc1_2107 1.71e-38 140.0 COG0348@1|root,COG1152@1|root,COG0348@2|Bacteria,COG1152@2|Bacteria,1MY5M@1224|Proteobacteria,2TR0X@28211|Alphaproteobacteria 28211|Alphaproteobacteria CK COG3901 Regulator of nitric oxide reductase transcription nosR - - ko:K19339,ko:K19343 - - - - ko00000,ko03000 - - - FMN_bind,Fer4_5 k59_464853_1 1168034.FH5T_06700 1.21e-103 310.0 COG0743@1|root,COG0743@2|Bacteria,4NG0S@976|Bacteroidetes,2FN5M@200643|Bacteroidia 976|Bacteroidetes I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_235501_1 290512.Paes_1268 1.11e-11 64.7 COG0079@1|root,COG0079@2|Bacteria,1FE4A@1090|Chlorobi 1090|Chlorobi E PFAM aminotransferase, class I and II - - 2.6.1.9,4.1.1.81 ko:K00817,ko:K04720 ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243,R06530 RC00006,RC00517,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_235501_2 765911.Thivi_1675 4.39e-19 87.8 COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,1RN84@1236|Gammaproteobacteria,1WXAF@135613|Chromatiales 135613|Chromatiales U Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_922425_1 1396858.Q666_07485 7.08e-29 110.0 COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,1RPZ6@1236|Gammaproteobacteria,465HE@72275|Alteromonadaceae 1236|Gammaproteobacteria D Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions slmA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0007049,GO:0007346,GO:0008150,GO:0009295,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010948,GO:0010974,GO:0016043,GO:0019219,GO:0019222,GO:0022402,GO:0022607,GO:0031323,GO:0031326,GO:0031333,GO:0032271,GO:0032272,GO:0032465,GO:0032466,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0043085,GO:0043087,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043547,GO:0043565,GO:0043590,GO:0044085,GO:0044087,GO:0044093,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045786,GO:0045930,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051252,GO:0051301,GO:0051302,GO:0051336,GO:0051345,GO:0051726,GO:0051782,GO:0060255,GO:0061640,GO:0065007,GO:0065009,GO:0071840,GO:0080090,GO:0090529,GO:0097159,GO:0140110,GO:1901363,GO:1901891,GO:1901892,GO:1902410,GO:1902412,GO:1902413,GO:1903047,GO:1903436,GO:1903437,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - ko:K05501 - - - - ko00000,ko03000,ko03036 - - - TetR_N k59_987329_1 1248916.ANFY01000009_gene84 1.2e-22 101.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2UP03@28211|Alphaproteobacteria,2KDWK@204457|Sphingomonadales 204457|Sphingomonadales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_366519_1 1123373.ATXI01000003_gene1316 4.62e-54 184.0 COG0486@1|root,COG0486@2|Bacteria,2GHES@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_725593_1 1116472.MGMO_120c00340 3.45e-81 267.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,1RMZH@1236|Gammaproteobacteria,1XEXC@135618|Methylococcales 135618|Methylococcales O C-terminal, D2-small domain, of ClpB protein - - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small k59_334192_1 1168034.FH5T_11200 2.21e-80 254.0 COG0168@1|root,COG0168@2|Bacteria,4NGMF@976|Bacteroidetes,2FNQZ@200643|Bacteroidia 976|Bacteroidetes P potassium uptake protein, TrkH family trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_72218_1 522306.CAP2UW1_4208 5.53e-92 279.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2VJEC@28216|Betaproteobacteria,1KQVI@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Bacterial extracellular solute-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_72218_2 570952.ATVH01000013_gene3036 9.1e-91 274.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,2JR2U@204441|Rhodospirillales 204441|Rhodospirillales P COG4149 ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_72218_3 1000565.METUNv1_01283 6.22e-13 67.4 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2WGQX@28216|Betaproteobacteria,2KZWD@206389|Rhodocyclales 206389|Rhodocyclales E ATPases associated with a variety of cellular activities - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran k59_1019970_1 1165841.SULAR_07605 2.63e-111 329.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2YMSC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_757993_1 1200792.AKYF01000018_gene5783 5.55e-31 135.0 COG3391@1|root,COG4385@1|root,COG3391@2|Bacteria,COG4385@2|Bacteria,1UZ1H@1239|Firmicutes,4HAFG@91061|Bacilli,26UC4@186822|Paenibacillaceae 91061|Bacilli S Phage tail protein (Tail_P2_I) - - - - - - - - - - - - Tail_P2_I k59_757993_2 1227487.C474_06812 1.68e-27 122.0 COG3299@1|root,arCOG10307@2157|Archaea,2XW0Z@28890|Euryarchaeota,23TZZ@183963|Halobacteria 183963|Halobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_823929_1 1118153.MOY_06937 0.000186 51.6 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1XISX@135619|Oceanospirillales 135619|Oceanospirillales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_725598_1 1038869.AXAN01000118_gene4563 4.42e-55 181.0 COG2801@1|root,COG2801@2|Bacteria,1MY62@1224|Proteobacteria,2VJAF@28216|Betaproteobacteria,1K2XD@119060|Burkholderiaceae 28216|Betaproteobacteria L transposase - - - - - - - - - - - - HTH_21,rve k59_888611_1 1232410.KI421426_gene1368 3.29e-32 123.0 COG4313@1|root,COG4313@2|Bacteria,1R58D@1224|Proteobacteria,42SAW@68525|delta/epsilon subdivisions,2WP5F@28221|Deltaproteobacteria,43VV8@69541|Desulfuromonadales 28221|Deltaproteobacteria C Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_856660_1 1168034.FH5T_08740 1.66e-168 491.0 COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,4NKCK@976|Bacteroidetes,2G172@200643|Bacteroidia 976|Bacteroidetes M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT,TPR_16,TPR_19,TPR_8 k59_38569_1 387093.SUN_0390 6.52e-81 249.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,42ND2@68525|delta/epsilon subdivisions,2YMQ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_2 k59_267564_1 1336233.JAEH01000040_gene4258 1.86e-22 94.0 COG4232@1|root,COG4232@2|Bacteria,1QJ3E@1224|Proteobacteria,1TH0Z@1236|Gammaproteobacteria,2QDT4@267890|Shewanellaceae 1236|Gammaproteobacteria CO PFAM cytochrome c biogenesis protein, transmembrane region - - - - - - - - - - - - DsbD_2 k59_267564_2 1499967.BAYZ01000050_gene2876 9.48e-17 79.3 COG0526@1|root,COG0526@2|Bacteria,2NQ68@2323|unclassified Bacteria 2|Bacteria CO COG0526, thiol-disulfide isomerase and thioredoxins resA_1 - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_1019978_1 552811.Dehly_0726 2.15e-46 166.0 COG3259@1|root,COG3259@2|Bacteria,2G68W@200795|Chloroflexi,34CQT@301297|Dehalococcoidia 301297|Dehalococcoidia C hydrogenase large subunit - - 1.8.98.5 ko:K14126 ko00680,map00680 - R00019,R11943 RC00011 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_823935_1 1168034.FH5T_11285 9.32e-62 196.0 COG0810@1|root,COG0810@2|Bacteria,4NMG7@976|Bacteroidetes,2FPKW@200643|Bacteroidia 976|Bacteroidetes M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_170770_1 314270.RB2083_3555 2.5e-05 45.4 COG1063@1|root,COG1063@2|Bacteria,1MWX0@1224|Proteobacteria,2TU6B@28211|Alphaproteobacteria,3ZGP6@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases yjjN GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034193,GO:0034195,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.14,1.1.1.380 ko:K00008,ko:K08322 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896,R10848 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_170770_2 349163.Acry_2066 2.01e-66 205.0 COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VG6E@28211|Alphaproteobacteria,2JT4M@204441|Rhodospirillales 204441|Rhodospirillales K helix_turn_helix ASNC type - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24 k59_627876_1 889378.Spiaf_0920 1.31e-31 119.0 COG2095@1|root,COG2095@2|Bacteria 2|Bacteria U MarC family integral membrane protein IV02_12955 - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_987358_1 387093.SUN_2096 4.61e-111 328.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2YMR8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_202742_1 106648.BBLJ01000085_gene4448 1.41e-152 433.0 COG1708@1|root,COG1708@2|Bacteria,1QVMI@1224|Proteobacteria,1RU4E@1236|Gammaproteobacteria,3NSZE@468|Moraxellaceae 1236|Gammaproteobacteria H Domain of unknown function (DUF4111) - - 2.7.7.47 ko:K00984 - - - - ko00000,ko01000,ko01504 - - - DUF4111,NTP_transf_2 k59_530203_1 272942.RCAP_rcc00029 1.24e-69 213.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria,1FBXV@1060|Rhodobacter 28211|Alphaproteobacteria U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_464888_1 1172190.M947_10000 5.28e-104 318.0 COG3203@1|root,COG3203@2|Bacteria,1R1K3@1224|Proteobacteria,43DCJ@68525|delta/epsilon subdivisions,2YTI4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M outer membrane porin, OprD family - - - - - - - - - - - - OprD k59_562831_1 398512.JQKC01000012_gene229 1.43e-25 103.0 COG1215@1|root,COG1215@2|Bacteria,1V1CB@1239|Firmicutes,24EMU@186801|Clostridia,3WH23@541000|Ruminococcaceae 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - - - - - - - - - - Glycos_transf_2 k59_562831_2 671065.MetMK1DRAFT_00027040 0.000568 45.8 COG0438@1|root,arCOG01408@2157|Archaea 2157|Archaea M Glycosyltransferase - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 k59_267583_1 411470.RUMGNA_00435 1.31e-124 373.0 COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,3XYYN@572511|Blautia 186801|Clostridia M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_300341_1 679897.HMU02620 4.59e-34 129.0 COG1216@1|root,COG1216@2|Bacteria,1QU2Q@1224|Proteobacteria,43BK5@68525|delta/epsilon subdivisions,2YN4Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M glycosyl transferase - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 k59_987373_1 387093.SUN_1850 2.07e-106 326.0 COG2374@1|root,COG2374@2|Bacteria,1RCTI@1224|Proteobacteria,42Q2J@68525|delta/epsilon subdivisions,2YNG1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_888654_1 435591.BDI_1625 1.3e-113 355.0 COG0383@1|root,COG0383@2|Bacteria,4NI6N@976|Bacteroidetes,2FQGF@200643|Bacteroidia 976|Bacteroidetes G COG COG0383 Alpha-mannosidase - - - - - - - - - - - - CBM-like,Glyco_hydro_38,Glyco_hydro_38C k59_627896_1 1049564.TevJSym_ax00410 2.44e-11 63.9 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3 k59_627896_2 870187.Thini_4247 9.13e-99 293.0 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,462II@72273|Thiotrichales 72273|Thiotrichales T helix_turn_helix, Lux Regulon - - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_627896_3 631362.Thi970DRAFT_04285 4.36e-65 202.0 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,1S98V@1236|Gammaproteobacteria,1WY49@135613|Chromatiales 135613|Chromatiales P PFAM Rhodanese-like - - - - - - - - - - - - Rhodanese k59_627896_4 713587.THITH_04055 1.02e-28 107.0 COG2932@1|root,COG2932@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - ko:K09384 - - - - ko00000 - - - DUF3427,HIT,HTH_31,Helicase_C,Methyltransf_25,PLDc_2,Peptidase_S24,ResIII k59_790554_2 1121104.AQXH01000001_gene1083 4.86e-11 61.6 COG0566@1|root,COG0566@2|Bacteria,4NM8C@976|Bacteroidetes,1IS2Z@117747|Sphingobacteriia 976|Bacteroidetes J SpoU rRNA Methylase family spoU - - - - - - - - - - - SpoU_methylase k59_661026_1 1463900.JOIX01000124_gene2794 2.96e-75 235.0 COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria 201174|Actinobacteria GK polyphosphate glucokinase ppgK - 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_758048_1 933115.GPDM_01950 1.34e-58 191.0 COG1177@1|root,COG1177@2|Bacteria,1URBC@1239|Firmicutes,4HHX1@91061|Bacilli,26GGJ@186818|Planococcaceae 91061|Bacilli P spermidine putrescine transport system, permease - - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_594865_1 754477.Q7C_1172 6.56e-65 207.0 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,4610F@72273|Thiotrichales 72273|Thiotrichales M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_594865_2 1384054.N790_10805 8.52e-07 50.4 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1X40P@135614|Xanthomonadales 135614|Xanthomonadales M murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_300348_1 572544.Ilyop_0230 2.8e-184 523.0 COG1160@1|root,COG1160@2|Bacteria,379J8@32066|Fusobacteria 32066|Fusobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_563306_1 1173023.KE650771_gene1855 8.68e-39 148.0 COG0855@1|root,COG0855@2|Bacteria,1G1WA@1117|Cyanobacteria,1JGY4@1189|Stigonemataceae 1117|Cyanobacteria P Polyphosphate kinase middle domain ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_563306_2 1267534.KB906762_gene1187 8.08e-11 63.2 COG1611@1|root,COG1611@2|Bacteria,3Y7Y0@57723|Acidobacteria,2JN31@204432|Acidobacteriia 204432|Acidobacteriia S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_236035_1 97138.C820_02188 4.1e-43 151.0 COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,36DHJ@31979|Clostridiaceae 186801|Clostridia D cell division ATP-binding protein FtsE ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_889148_1 765913.ThidrDRAFT_0356 0.0 1277.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales 135613|Chromatiales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_889148_2 765910.MARPU_02750 9.65e-143 412.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales 135613|Chromatiales H Belongs to the ribF family - - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_889148_3 768671.ThimaDRAFT_2243 2.38e-223 632.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales 135613|Chromatiales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_889148_4 765912.Thimo_2657 8.1e-35 120.0 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1WYU8@135613|Chromatiales 135613|Chromatiales J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_267977_1 471870.BACINT_04409 8.61e-68 226.0 COG3193@1|root,COG3193@2|Bacteria,4PMW5@976|Bacteroidetes,2G0J1@200643|Bacteroidia,4AV96@815|Bacteroidaceae 976|Bacteroidetes S COG NOG31573 non supervised orthologous group - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_105901_1 1121904.ARBP01000017_gene5158 3.02e-88 275.0 COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,47MQK@768503|Cytophagia 976|Bacteroidetes P Arylsulfatase A - - - - - - - - - - - - DUF4976,Sulfatase k59_138637_1 1121396.KB893088_gene360 6.29e-91 283.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_334779_1 1168034.FH5T_03810 4.76e-122 363.0 COG0572@1|root,COG0572@2|Bacteria,4NIHT@976|Bacteroidetes,2FP3D@200643|Bacteroidia 976|Bacteroidetes FJ Phosphoribulokinase Uridine kinase family udk2 - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK k59_563318_1 387093.SUN_0354 5.06e-141 404.0 COG1387@1|root,COG1387@2|Bacteria,1MX8T@1224|Proteobacteria,43BI2@68525|delta/epsilon subdivisions,2YT8M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E PHP domain - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP,PHP_C k59_790829_1 1168034.FH5T_05790 1.73e-111 327.0 COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,2FPCB@200643|Bacteroidia 976|Bacteroidetes C iron-sulfur cluster-binding protein queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_790829_2 1121904.ARBP01000013_gene349 9.32e-61 201.0 COG4948@1|root,COG4948@2|Bacteria,4NKNN@976|Bacteroidetes,47JKW@768503|Cytophagia 976|Bacteroidetes M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_267983_1 1168034.FH5T_02885 9.13e-53 176.0 COG3712@1|root,COG3712@2|Bacteria,4PINM@976|Bacteroidetes,2FRVF@200643|Bacteroidia 976|Bacteroidetes PT FecR protein - - - - - - - - - - - - FecR k59_105906_1 1168034.FH5T_07845 1.79e-100 301.0 COG3823@1|root,COG3823@2|Bacteria,4NF2M@976|Bacteroidetes,2FS7M@200643|Bacteroidia 976|Bacteroidetes O Glutamine cyclotransferase - - 2.3.2.5 ko:K00683 - - - - ko00000,ko01000 - - - Glu_cyclase_2 k59_171090_1 526218.Sterm_1014 1.78e-54 181.0 COG2073@1|root,COG2073@2|Bacteria,378UN@32066|Fusobacteria 32066|Fusobacteria H Psort location Cytoplasmic, score 8.96 - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid k59_171090_2 526218.Sterm_1015 1.06e-124 360.0 COG1010@1|root,COG1010@2|Bacteria,378MZ@32066|Fusobacteria 32066|Fusobacteria H precorrin-3B C17-methyltransferase cobJ - 2.1.1.131 ko:K05934 ko00860,ko01100,map00860,map01100 - R05180,R05809 RC00003,RC01293,RC03471 ko00000,ko00001,ko01000 - - - TP_methylase k59_987891_1 572544.Ilyop_1327 1.12e-49 163.0 COG0663@1|root,COG0663@2|Bacteria,37A6B@32066|Fusobacteria 32066|Fusobacteria S Bacterial transferase hexapeptide repeat protein - - - - - - - - - - - - Hexapep k59_987891_2 572544.Ilyop_1328 4.26e-105 306.0 COG4752@1|root,COG4752@2|Bacteria,378YP@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Methyltrn_RNA_4 k59_987891_3 572544.Ilyop_1627 1.13e-270 747.0 COG2848@1|root,COG2848@2|Bacteria,3794H@32066|Fusobacteria 32066|Fusobacteria S UPF0210 protein - - - ko:K09157 - - - - ko00000 - - - DUF711 k59_987891_4 999411.HMPREF1092_01300 2.37e-17 77.0 COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia,36KHG@31979|Clostridiaceae 186801|Clostridia T Belongs to the UPF0237 family - - - ko:K07166 - - - - ko00000 - - - ACT_6 k59_987891_5 572544.Ilyop_0749 1.64e-136 397.0 COG1482@1|root,COG1482@2|Bacteria,378PU@32066|Fusobacteria 32066|Fusobacteria G mannose-6-phosphate isomerase manA - 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 - - - PMI_typeI k59_987891_6 572544.Ilyop_1586 1.27e-43 144.0 COG1342@1|root,COG1342@2|Bacteria,37AMV@32066|Fusobacteria 32066|Fusobacteria S Belongs to the UPF0251 family - - - - - - - - - - - - DUF134 k59_987891_8 1286171.EAL2_c19280 2.72e-46 166.0 COG1541@1|root,COG1541@2|Bacteria,1UYWT@1239|Firmicutes,2496I@186801|Clostridia,25X9F@186806|Eubacteriaceae 186801|Clostridia H coenzyme F390 synthetase - - - - - - - - - - - - AMP-binding k59_203340_1 58123.JOFJ01000027_gene2777 2.56e-71 224.0 COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4EH8P@85012|Streptosporangiales 201174|Actinobacteria GK ROK family ppgK - 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_399395_1 572544.Ilyop_0323 2.9e-66 207.0 COG3863@1|root,COG3863@2|Bacteria,3792C@32066|Fusobacteria 32066|Fusobacteria S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 k59_300789_1 1027273.GZ77_26030 3.92e-46 164.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,1RZTT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L to GP 6723233 - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_334792_1 1158614.I592_03748 2.87e-35 124.0 2DMS0@1|root,32T9Q@2|Bacteria,1VCJ5@1239|Firmicutes,4HN6D@91061|Bacilli,4B3F5@81852|Enterococcaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_334792_2 1122947.FR7_2768 3.29e-27 103.0 2DMKJ@1|root,32S74@2|Bacteria,1VC4F@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_628508_1 1232437.KL661986_gene3679 1.38e-60 209.0 COG3829@1|root,COG3852@1|root,COG4564@1|root,COG3829@2|Bacteria,COG3852@2|Bacteria,COG4564@2|Bacteria,1QW3X@1224|Proteobacteria,42YCI@68525|delta/epsilon subdivisions 1224|Proteobacteria T PAS fold - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE k59_497969_1 192952.MM_1198 4.18e-60 200.0 arCOG04931@1|root,arCOG04931@2157|Archaea,2XZHF@28890|Euryarchaeota 28890|Euryarchaeota - - - - - - - - - - - - - - - k59_889180_1 1384054.N790_14300 4.7e-49 176.0 COG4772@1|root,COG4772@2|Bacteria,1MWDG@1224|Proteobacteria,1RQA5@1236|Gammaproteobacteria,1X5QP@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K16091 - - - - ko00000,ko02000 1.B.14.1.14 - - Plug,TonB_dep_Rec k59_954726_1 1319815.HMPREF0202_00127 2.37e-58 191.0 COG1175@1|root,COG1175@2|Bacteria,37C9U@32066|Fusobacteria 32066|Fusobacteria U Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_954726_2 1319815.HMPREF0202_00128 1.44e-168 485.0 COG2182@1|root,COG2182@2|Bacteria,37CDV@32066|Fusobacteria 32066|Fusobacteria G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 k59_497977_1 1168034.FH5T_08615 7.34e-86 265.0 COG2610@1|root,COG2610@2|Bacteria,4NFBD@976|Bacteroidetes 976|Bacteroidetes EG Gluconate transporter - - - ko:K03299,ko:K06156 - - - - ko00000,ko02000 2.A.8,2.A.8.1.8 - - GntP_permease k59_171102_1 349520.PPE_00003 1.4e-21 86.3 COG2501@1|root,COG2501@2|Bacteria,1VEJ2@1239|Firmicutes,4HNMC@91061|Bacilli,26ZS1@186822|Paenibacillaceae 91061|Bacilli S RNA-binding protein S4 yaaA - - ko:K14761 - - - - ko00000,ko03009 - - - S4_2 k59_171102_2 572544.Ilyop_0003 3.6e-153 442.0 COG1195@1|root,COG1195@2|Bacteria,3787C@32066|Fusobacteria 32066|Fusobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_23,SMC_N k59_171102_3 469618.FVAG_02461 5.02e-14 69.7 COG5512@1|root,COG5512@2|Bacteria 2|Bacteria L Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - - - - - - - - - - DUF721 k59_889190_1 1057002.KB905370_gene2611 2.14e-30 123.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_8 k59_465371_1 1163617.SCD_n02227 7.26e-17 82.4 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,2WGKB@28216|Betaproteobacteria 28216|Betaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_465371_2 237368.SCABRO_02415 4.7e-143 416.0 COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes 203682|Planctomycetes P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_465371_3 634498.mru_1013 6.13e-16 78.2 COG2081@1|root,arCOG00575@2157|Archaea,2XWX6@28890|Euryarchaeota,23NYK@183925|Methanobacteria 183925|Methanobacteria S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_923057_1 335543.Sfum_2118 1.81e-63 212.0 COG0539@1|root,COG1093@1|root,COG0539@2|Bacteria,COG1093@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MR1P@213462|Syntrophobacterales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_758628_1 1366050.N234_14725 4.8e-68 218.0 COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2VGZS@28216|Betaproteobacteria,1K1VD@119060|Burkholderiaceae 28216|Betaproteobacteria C Ferredoxin--NADP reductase trxB2 - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3 k59_923060_2 324602.Caur_0678 7.34e-54 189.0 COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi 200795|Chloroflexi C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_693740_1 1408417.JHYB01000002_gene380 5.6e-14 74.7 COG0389@1|root,COG0389@2|Bacteria,3WT2B@544448|Tenericutes 544448|Tenericutes L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_693740_2 572544.Ilyop_1546 3.24e-203 580.0 COG2317@1|root,COG2317@2|Bacteria,378BC@32066|Fusobacteria 32066|Fusobacteria E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 k59_693740_3 1211814.CAPG01000041_gene2347 1.48e-34 129.0 COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,4HHRQ@91061|Bacilli,1ZC72@1386|Bacillus 91061|Bacilli S COG0491 Zn-dependent hydrolases, including glyoxylases yqgX - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B k59_693740_4 1499689.CCNN01000007_gene2161 1.03e-77 246.0 COG1362@1|root,COG1362@2|Bacteria,1TQ3Z@1239|Firmicutes,248UP@186801|Clostridia,36EV0@31979|Clostridiaceae 186801|Clostridia E M18 family aminopeptidase apeB - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k59_595481_1 314285.KT71_03132 3.93e-88 277.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,1J5GX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain alsS - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_661585_1 1168034.FH5T_12440 8.43e-204 568.0 COG0205@1|root,COG0205@2|Bacteria,4NGN7@976|Bacteroidetes,2FNIF@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_661585_2 1296415.JACC01000030_gene2801 4.64e-32 118.0 COG0357@1|root,COG0357@2|Bacteria,4NEJG@976|Bacteroidetes,1HYFU@117743|Flavobacteriia,2YHFD@290174|Aquimarina 976|Bacteroidetes M rRNA small subunit methyltransferase G rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_465382_1 445971.ANASTE_01335 1.51e-24 97.1 2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia,25X4H@186806|Eubacteriaceae 186801|Clostridia - - - - - - - - - - - - - - Cytochrom_B561 k59_628539_1 1519464.HY22_07245 1.59e-60 194.0 COG4783@1|root,COG4783@2|Bacteria,1FFG5@1090|Chlorobi 1090|Chlorobi S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_367117_1 1165841.SULAR_05298 2.4e-194 557.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,43BJ2@68525|delta/epsilon subdivisions,2YN49@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II and III secretion system protein ctsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - STN,Secretin,Secretin_N_2 k59_268027_1 877415.JNJQ01000001_gene1929 1.49e-14 75.9 2EXVQ@1|root,344YQ@2|Bacteria,1W097@1239|Firmicutes 1239|Firmicutes S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_856931_1 1049564.TevJSym_au00280 6.08e-43 141.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,1J6K6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_856931_2 396588.Tgr7_0941 0.0 1164.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_856931_3 765913.ThidrDRAFT_1255 1.51e-245 681.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1WX82@135613|Chromatiales 135613|Chromatiales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_856931_4 998674.ATTE01000001_gene673 3.28e-110 321.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,45ZYA@72273|Thiotrichales 72273|Thiotrichales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_856931_5 349521.HCH_02157 5.69e-122 368.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1XHKR@135619|Oceanospirillales 135619|Oceanospirillales D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_856931_6 1049564.TevJSym_an00600 3.7e-144 415.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1J543@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_856931_7 1049564.TevJSym_an00610 9.7e-296 824.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1J4DW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_856931_8 1095769.CAHF01000001_gene3476 1.38e-30 112.0 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,474V1@75682|Oxalobacteraceae 28216|Betaproteobacteria U Preprotein translocase subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_856931_9 1049564.TevJSym_ab00750 4.25e-195 554.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1J4E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine - - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_856931_10 382245.ASA_0794 8.9e-48 165.0 COG0671@1|root,COG0671@2|Bacteria,1MW7A@1224|Proteobacteria,1RPKF@1236|Gammaproteobacteria,1Y4MI@135624|Aeromonadales 135624|Aeromonadales I Acid phosphatase homologues - - 2.7.4.29 ko:K19803 - - R11186 RC00002 ko00000,ko01000,ko01005 - - - PAP2 k59_856931_11 743721.Psesu_1748 1.02e-102 306.0 COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,1RP5T@1236|Gammaproteobacteria,1X402@135614|Xanthomonadales 135614|Xanthomonadales L Hydrolase, TatD family yjjV - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_856931_12 519989.ECTPHS_01429 9.55e-94 282.0 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,1WXXZ@135613|Chromatiales 135613|Chromatiales H PFAM UBA THIF-type NAD FAD binding - - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_856931_13 203124.Tery_3603 6.31e-132 384.0 COG0664@1|root,COG1803@1|root,COG0664@2|Bacteria,COG1803@2|Bacteria,1G783@1117|Cyanobacteria,1HBYD@1150|Oscillatoriales 1117|Cyanobacteria G Methylglyoxal synthase - - 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - - cNMP_binding k59_856931_14 523791.Kkor_2525 1.81e-77 238.0 2AQI0@1|root,31FQP@2|Bacteria,1RI31@1224|Proteobacteria,1S4IS@1236|Gammaproteobacteria,1XPRH@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_856931_15 517418.Ctha_1855 1.23e-210 596.0 COG0114@1|root,COG0114@2|Bacteria,1FDI0@1090|Chlorobi 1090|Chlorobi C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_856931_16 1033802.SSPSH_003037 0.0 1190.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046487,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_436,iECOK1_1307.ECOK1_1491,iECS88_1305.ECS88_1416,iJN746.PP_2112,iUMN146_1321.UM146_10390,iUTI89_1310.UTI89_C1547 Aconitase,Aconitase_C k59_856931_17 158190.SpiGrapes_2371 9.27e-20 87.8 COG1633@1|root,COG1633@2|Bacteria 2|Bacteria S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - - - - - - - - - - Rubrerythrin k59_856931_18 857293.CAAU_1184 1.04e-22 108.0 COG2199@1|root,COG2203@1|root,COG3899@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,36E8P@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - AAA_16,GGDEF,Pkinase,TPR_12,TPR_8 k59_856931_20 314278.NB231_11589 5.88e-21 87.0 COG4783@1|root,COG4783@2|Bacteria,1QYTN@1224|Proteobacteria,1T3U7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_856931_21 492774.JQMB01000007_gene4171 1.3e-108 325.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,4B7TE@82115|Rhizobiaceae 28211|Alphaproteobacteria P metal ion binding MA20_22850 - - - - - - - - - - - Lactamase_B,Rhodanese k59_856931_22 935557.ATYB01000014_gene1769 1.93e-64 221.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,4BCTX@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_856931_23 998674.ATTE01000001_gene2611 1.91e-87 258.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria,4629N@72273|Thiotrichales 72273|Thiotrichales C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_856931_24 1049564.TevJSym_bd00260 1.18e-269 744.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1J7KN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain glpC GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3 ko:K00113,ko:K11473 ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130 - R00475,R00848 RC00029,RC00042 ko00000,ko00001,ko01000 - - - CCG,Fer4_8 k59_856931_25 580332.Slit_0304 9.44e-87 260.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2VRBG@28216|Betaproteobacteria 28216|Betaproteobacteria C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_856931_26 1265313.HRUBRA_00603 5.47e-104 304.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1J4K8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050 Sod_Fe_C,Sod_Fe_N k59_856931_27 1499967.BAYZ01000143_gene6124 1.41e-86 258.0 COG2077@1|root,COG2077@2|Bacteria,2NQ0A@2323|unclassified Bacteria 2|Bacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0020012,GO:0030312,GO:0030682,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin k59_856931_28 246197.MXAN_6624 3.31e-50 169.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,2YV5F@29|Myxococcales 28221|Deltaproteobacteria O Redoxin prx-4 - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_856931_30 1301100.HG529290_gene5175 1.5e-15 69.3 2BNQF@1|root,32HDS@2|Bacteria,1UFVA@1239|Firmicutes,24UJ5@186801|Clostridia,36PBE@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - DUF4177 k59_856931_31 472759.Nhal_3579 2.88e-47 156.0 2BC31@1|root,325MS@2|Bacteria,1NBYV@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_856931_33 1121405.dsmv_0900 1.25e-81 246.0 COG3945@1|root,COG3945@2|Bacteria,1N3AR@1224|Proteobacteria,42UWM@68525|delta/epsilon subdivisions,2WQEC@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_856931_34 107636.JQNK01000009_gene3438 1.92e-52 170.0 COG3435@1|root,COG3435@2|Bacteria,1RFPN@1224|Proteobacteria 1224|Proteobacteria Q Cupin domain - - - - - - - - - - - - Cupin_2 k59_73661_1 469596.HMPREF9488_02950 1.65e-105 319.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,3VPSC@526524|Erysipelotrichia 526524|Erysipelotrichia C Psort location Cytoplasmic, score gltA - - - - - - - - - - - Fer4_20,Pyr_redox_2 k59_498803_1 439235.Dalk_3337 3.39e-32 125.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42NSP@68525|delta/epsilon subdivisions,2WMAD@28221|Deltaproteobacteria,2MHRF@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase N terminal - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_498803_2 998674.ATTE01000001_gene482 4.85e-20 85.9 2E4SV@1|root,32ZM7@2|Bacteria,1N8VN@1224|Proteobacteria,1S6AW@1236|Gammaproteobacteria,462T2@72273|Thiotrichales 72273|Thiotrichales S Putative transmembrane protein (PGPGW) - - - - - - - - - - - - PGPGW k59_204194_1 257313.BP2041 4.96e-86 266.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,3T2WB@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_988729_1 762982.HMPREF9442_02506 2.16e-20 95.5 COG0561@1|root,COG0561@2|Bacteria,4PNWK@976|Bacteroidetes,2G125@200643|Bacteroidia 976|Bacteroidetes S Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_564100_1 1137799.GZ78_28925 1.05e-68 211.0 COG1943@1|root,COG1943@2|Bacteria,1RI1H@1224|Proteobacteria,1T1BV@1236|Gammaproteobacteria,1XQ50@135619|Oceanospirillales 1236|Gammaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_335669_2 1049564.TevJSym_as00370 3.59e-96 285.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1J5SJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212 Ham1p_like k59_466054_1 545276.KB898730_gene1481 3.66e-62 200.0 COG0121@1|root,COG0121@2|Bacteria,1PX9X@1224|Proteobacteria,1SBGN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutamine amidotransferase egtC - - - - - - - - - - - GATase_4 k59_466054_2 998674.ATTE01000001_gene368 4.93e-39 139.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,460CS@72273|Thiotrichales 72273|Thiotrichales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_759385_1 385682.AFSL01000026_gene622 3.21e-66 215.0 COG0534@1|root,COG0534@2|Bacteria,4NG7Q@976|Bacteroidetes,2FN68@200643|Bacteroidia,3XJEP@558415|Marinilabiliaceae 976|Bacteroidetes V MatE dinF - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1021289_1 1249480.B649_11605 5.73e-75 232.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2YMMF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Abc transporter - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_5143_1 697282.Mettu_1672 1.37e-31 111.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XFQ2@135618|Methylococcales 135618|Methylococcales K SMART Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_466057_1 765911.Thivi_1669 8.75e-46 157.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1WWUS@135613|Chromatiales 135613|Chromatiales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_466057_2 1123392.AQWL01000002_gene2000 1.69e-47 160.0 COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,2WBNB@28216|Betaproteobacteria,1KS8Q@119069|Hydrogenophilales 119069|Hydrogenophilales V (ABC) transporter - - - - - - - - - - - - - k59_596335_1 1121930.AQXG01000005_gene699 5.99e-59 204.0 COG0058@1|root,COG0058@2|Bacteria,4NGR1@976|Bacteroidetes 976|Bacteroidetes G alpha-glucan phosphorylase - - - - - - - - - - - - Phosphorylase k59_923796_1 1254432.SCE1572_05815 3.58e-88 294.0 COG0204@1|root,COG0764@1|root,COG3321@1|root,COG0204@2|Bacteria,COG0764@2|Bacteria,COG3321@2|Bacteria,1QUWM@1224|Proteobacteria,43BRB@68525|delta/epsilon subdivisions,2WJJ6@28221|Deltaproteobacteria,2YZMR@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the beta-ketoacyl-ACP synthases family - - - - - - - - - - - - Acyl_transf_1,Acyltransferase,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt k59_370360_1 118161.KB235922_gene5034 1.07e-35 135.0 COG3547@1|root,COG3547@2|Bacteria,1GA7N@1117|Cyanobacteria,3VJGI@52604|Pleurocapsales 1117|Cyanobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_926254_1 768671.ThimaDRAFT_0777 3.99e-101 307.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales 135613|Chromatiales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_206851_1 748247.AZKH_p0450 1.74e-54 179.0 COG0705@1|root,COG0705@2|Bacteria,1RJYI@1224|Proteobacteria,2W1AJ@28216|Betaproteobacteria,2KXTX@206389|Rhodocyclales 206389|Rhodocyclales S Rhomboid family - - - - - - - - - - - - Rhomboid k59_76117_1 1120953.AUBH01000002_gene1407 4.89e-27 110.0 COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,1RMI9@1236|Gammaproteobacteria,464FR@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_76117_2 1333856.L686_07080 4.96e-64 209.0 COG0010@1|root,COG0010@2|Bacteria,1NCRN@1224|Proteobacteria,1RNKI@1236|Gammaproteobacteria,1Z3P6@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Arginase family hutG GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016813,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.3.11,3.5.3.8 ko:K01479,ko:K01480 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_338347_1 1283284.AZUK01000001_gene817 5.11e-10 66.2 COG0745@1|root,COG2199@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1R7HC@1224|Proteobacteria,1T2D4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T response regulator - - - - - - - - - - - - CHASE3,GAF_2,GGDEF,HATPase_c,HisKA,Response_reg k59_6591_2 469616.FMAG_00929 6.33e-54 188.0 COG0553@1|root,COG0553@2|Bacteria,37926@32066|Fusobacteria 32066|Fusobacteria L domain protein - - - - - - - - - - - - Helicase_C,PLDc_2,SNF2_N k59_792787_1 616991.JPOO01000001_gene2841 3.6e-76 243.0 COG3119@1|root,COG3119@2|Bacteria,4NF1X@976|Bacteroidetes,1HYYH@117743|Flavobacteriia,23GVX@178469|Arenibacter 976|Bacteroidetes P Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - DUF4976,Sulfatase k59_370373_1 1121405.dsmv_2490 2.57e-84 257.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42MZE@68525|delta/epsilon subdivisions,2WKJB@28221|Deltaproteobacteria,2MJDV@213118|Desulfobacterales 28221|Deltaproteobacteria P TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - iAF987.Gmet_0512 SBP_bac_11 k59_142189_1 1265505.ATUG01000002_gene1621 1.57e-106 333.0 COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2MIPK@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_664832_1 1168034.FH5T_10165 4.66e-96 294.0 COG1774@1|root,COG1774@2|Bacteria,4NENX@976|Bacteroidetes,2FNYP@200643|Bacteroidia 976|Bacteroidetes S PSP1 C-terminal domain protein yaaT - - - - - - - - - - - PSP1 k59_206855_1 227377.CBU_1544 8.36e-64 208.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1JEXQ@118969|Legionellales 118969|Legionellales L Helix-turn-helix domain - - - - - - - - - - - - HTH_38,rve k59_991403_1 1123320.KB889675_gene3974 2.3e-46 174.0 COG0477@1|root,COG2814@2|Bacteria,2H4H5@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator Superfamily - - - ko:K05557 - - - - ko00000,ko02000 2.A.1.3.7 - - MFS_1 k59_859675_1 458817.Shal_3606 1.05e-45 163.0 COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,1T2MN@1236|Gammaproteobacteria,2Q8XX@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase HAMP region domain protein - - - - - - - - - - - - HATPase_c k59_468286_1 3847.GLYMA13G11980.1 1.35e-17 81.3 2CUMQ@1|root,2RN4M@2759|Eukaryota,37U2D@33090|Viridiplantae,3GX5D@35493|Streptophyta,4JTXP@91835|fabids 35493|Streptophyta - - - - - - - - - - - - - - - k59_142197_1 1446473.JHWH01000009_gene335 1.87e-97 305.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2PUDT@265|Paracoccus 28211|Alphaproteobacteria E FAD dependent oxidoreductase central domain sardh - 1.5.3.19 ko:K19191 ko00760,ko01120,map00760,map01120 - R10102 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_957915_1 1232437.KL662036_gene2708 1.34e-36 126.0 COG0748@1|root,COG0748@2|Bacteria,1N2JV@1224|Proteobacteria,42TYW@68525|delta/epsilon subdivisions,2WQEM@28221|Deltaproteobacteria,2MK6D@213118|Desulfobacterales 28221|Deltaproteobacteria P Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx k59_957915_2 690850.Desaf_1369 4.73e-17 81.3 COG1413@1|root,COG1413@2|Bacteria,1R6G4@1224|Proteobacteria,42T2X@68525|delta/epsilon subdivisions,2WPNC@28221|Deltaproteobacteria,2MANX@213115|Desulfovibrionales 28221|Deltaproteobacteria C lyase activity - - - - - - - - - - - - HEAT_2,HEAT_EZ k59_631778_1 1255043.TVNIR_3306 1.95e-31 111.0 COG2026@1|root,COG2026@2|Bacteria,1N76D@1224|Proteobacteria,1SCNM@1236|Gammaproteobacteria,1WZG1@135613|Chromatiales 135613|Chromatiales DJ TIGRFAM Addiction module toxin, RelE StbE - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin k59_631778_2 768671.ThimaDRAFT_0488 1.71e-34 119.0 COG4710@1|root,COG4710@2|Bacteria,1QDBM@1224|Proteobacteria,1T99M@1236|Gammaproteobacteria,1X1D9@135613|Chromatiales 135613|Chromatiales S Ribbon-helix-helix protein, copG family - - - ko:K18918 - - - - ko00000,ko02048,ko03000 - - - RHH_1 k59_792790_1 571.MC52_30130 1.12e-143 421.0 COG3385@1|root,COG3385@2|Bacteria,1RBZF@1224|Proteobacteria,1S381@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_206863_1 1123326.JFBL01000004_gene2212 1.79e-66 231.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2YN0Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_599100_1 617140.AJZE01000079_gene1834 7.49e-84 268.0 COG2873@1|root,COG2873@2|Bacteria,1R3QG@1224|Proteobacteria,1RNSA@1236|Gammaproteobacteria,1XUQ3@135623|Vibrionales 135623|Vibrionales E Cys Met metabolism pyridoxal-phosphate-dependent enzyme - - - - - - - - - - - - Cys_Met_Meta_PP k59_370391_1 1054213.HMPREF9946_00367 3.48e-107 319.0 COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2TT8T@28211|Alphaproteobacteria,2JS24@204441|Rhodospirillales 204441|Rhodospirillales Q Catechol dioxygenase N terminus - - - - - - - - - - - - Dioxygenase_C,Dioxygenase_N k59_370391_2 1488328.JMCL01000097_gene4350 2.21e-16 75.9 COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,1RR4T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Conserved protein domain typically associated with flavoprotein oxygenases DIM6 NTAB family IV02_24660 - - - - - - - - - - - Flavin_Reduct k59_338368_1 1168034.FH5T_17170 5.53e-110 330.0 COG4108@1|root,COG4108@2|Bacteria,4NFEZ@976|Bacteroidetes,2FN0A@200643|Bacteroidia 976|Bacteroidetes J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,RF3_C k59_239165_1 1168289.AJKI01000021_gene1767 8.82e-80 255.0 COG2730@1|root,COG4886@1|root,COG2730@2|Bacteria,COG4886@2|Bacteria,4NEU5@976|Bacteroidetes,2FNKD@200643|Bacteroidia,3XINH@558415|Marinilabiliaceae 976|Bacteroidetes G Cellulase (glycosyl hydrolase family 5) celA GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0033946,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0052736,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - BACON,Cellulase,RicinB_lectin_2 k59_892745_1 1227349.C170_27733 5.52e-21 94.7 COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,4HTJJ@91061|Bacilli,274SR@186822|Paenibacillaceae 91061|Bacilli G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_859694_1 1123400.KB904758_gene2344 1.92e-90 275.0 COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,1RRAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphatidate cytidylyltransferase ynbB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009273,GO:0009987,GO:0016020,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071840,GO:0071944 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_859694_2 1441930.Z042_12050 2.69e-18 82.4 COG0204@1|root,COG0204@2|Bacteria,1RA8V@1224|Proteobacteria,1S4RP@1236|Gammaproteobacteria,402V2@613|Serratia 1236|Gammaproteobacteria I Acyltransferase - - - - - - - - - - - - Acyltransferase k59_696698_1 1444712.BN1013_02279 1e-36 148.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - - - - - - - - - - DUF853,DUF87 k59_41679_1 2340.JV46_11210 7.06e-81 249.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1J5F5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_893298_3 740709.A10D4_08057 6.99e-29 105.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,2QGHJ@267893|Idiomarinaceae 1236|Gammaproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K08998 - - - - ko00000 - - - Haemolytic k59_893298_4 572544.Ilyop_1905 6.04e-96 285.0 COG0706@1|root,COG0706@2|Bacteria,3790K@32066|Fusobacteria 32066|Fusobacteria U Psort location CytoplasmicMembrane, score spoIIIJ - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP k59_729111_1 1217718.ALOU01000066_gene1937 5.55e-25 103.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,1K30A@119060|Burkholderiaceae 28216|Betaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_729111_2 90813.JQMT01000001_gene2053 1.79e-58 194.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,45ZNS@72273|Thiotrichales 72273|Thiotrichales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_599699_1 1449126.JQKL01000002_gene1582 1.38e-24 100.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,268TR@186813|unclassified Clostridiales 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - ko:K07775 ko02020,map02020 M00458 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_599699_2 1391646.AVSU01000147_gene3312 1.42e-10 67.4 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_599699_3 1540257.JQMW01000009_gene2929 1.85e-06 52.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36DKF@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_860268_1 1165841.SULAR_08187 1.04e-98 313.0 COG0249@1|root,COG1403@1|root,COG0249@2|Bacteria,COG1403@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2YN6Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DNA mismatch repair MutS family mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_III,MutS_V k59_142800_1 1168034.FH5T_02685 1.47e-71 226.0 COG1193@1|root,COG1193@2|Bacteria,4NNNV@976|Bacteroidetes,2FMM1@200643|Bacteroidia 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF2027,Smr k59_632357_2 633148.Tagg_1239 2.5e-11 60.1 COG3350@1|root,arCOG04507@2157|Archaea,2XR9V@28889|Crenarchaeota 28889|Crenarchaeota S PFAM YHS domain - - - - - - - - - - - - YHS k59_304096_1 1537917.JU82_11520 1.49e-97 304.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2YM83@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_599707_1 563040.Saut_0531 4.82e-78 242.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2YMUH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - iIT341.HP0921 Gp_dh_C,Gp_dh_N k59_599707_2 632518.Calow_1184 2.96e-06 48.5 COG0126@1|root,COG0149@1|root,COG0126@2|Bacteria,COG0149@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales 186801|Clostridia F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_6963_1 160799.PBOR_01025 7.3e-42 159.0 COG3866@1|root,COG3866@2|Bacteria,1TSAU@1239|Firmicutes,4HUVA@91061|Bacilli,26SGC@186822|Paenibacillaceae 91061|Bacilli G Pectate lyase pel1 - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C k59_175008_1 998674.ATTE01000001_gene2267 5.26e-71 221.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,460HV@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_175008_2 998674.ATTE01000001_gene2266 7.15e-59 186.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,460EK@72273|Thiotrichales 72273|Thiotrichales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_567093_1 335543.Sfum_0016 1.12e-108 319.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,2MR5W@213462|Syntrophobacterales 28221|Deltaproteobacteria C ferredoxin oxidoreductase beta subunit korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_42180_1 1168034.FH5T_07310 9.19e-253 713.0 COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,2FNAU@200643|Bacteroidia 976|Bacteroidetes M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_402883_1 981383.AEWH01000063_gene1905 8.65e-28 102.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli 91061|Bacilli K Cold-Shock Protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_402883_4 1121090.KB894694_gene2143 2.97e-117 350.0 COG0687@1|root,COG0687@2|Bacteria,1TPY1@1239|Firmicutes,4HECD@91061|Bacilli,1ZQ8E@1386|Bacillus 91061|Bacilli P Spermidine putrescine ABC transporter substrate-binding protein potD - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - SBP_bac_8 k59_402883_5 37659.JNLN01000001_gene2057 4e-23 98.2 COG0687@1|root,COG1177@1|root,COG0687@2|Bacteria,COG1177@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia,36DK4@31979|Clostridiaceae 186801|Clostridia P Spermidine putrescine-binding periplasmic protein potD - - ko:K11069,ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1,SBP_bac_6,SBP_bac_8 k59_992006_1 1168034.FH5T_09815 1.24e-52 176.0 COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,2FM7Y@200643|Bacteroidia 976|Bacteroidetes L Belongs to the DEAD box helicase family deaD - - - - - - - - - - - DEAD,Helicase_C k59_992006_2 1168034.FH5T_09810 1.12e-89 272.0 COG0109@1|root,COG0109@2|Bacteria,4NF5A@976|Bacteroidetes 976|Bacteroidetes O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_175014_1 765912.Thimo_2542 6.75e-38 134.0 COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,1SCTT@1236|Gammaproteobacteria,1WZIB@135613|Chromatiales 135613|Chromatiales J Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamE - - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA k59_175014_2 754476.Q7A_2179 3.23e-30 110.0 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,4614M@72273|Thiotrichales 72273|Thiotrichales S Belongs to the UPF0125 (RnfH) family - - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_175014_3 631362.Thi970DRAFT_04294 6.44e-28 104.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1WY06@135613|Chromatiales 135613|Chromatiales I Cyclase dehydrase - - - - - - - - - - - - Polyketide_cyc k59_793103_1 519989.ECTPHS_03212 2.98e-118 344.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1WXR9@135613|Chromatiales 135613|Chromatiales IQ PFAM Short-chain dehydrogenase reductase SDR fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_793103_2 1049564.TevJSym_bc00130 3.86e-177 499.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1J5D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360 ACP_syn_III,ACP_syn_III_C k59_793103_3 765912.Thimo_2383 1.52e-150 433.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales 135613|Chromatiales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_793103_4 754476.Q7A_2018 3.66e-28 102.0 COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,46158@72273|Thiotrichales 72273|Thiotrichales J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_793103_5 393595.ABO_1065 6.89e-30 114.0 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1XJKJ@135619|Oceanospirillales 135619|Oceanospirillales S metal-binding, possibly nucleic acid-binding protein - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_793103_6 1049564.TevJSym_bc00090 1.54e-218 608.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,1J570@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit oadB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_793103_7 1049564.TevJSym_bc00080 1.89e-299 832.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1J4MJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CI COG5016 Pyruvate oxaloacetate carboxyltransferase oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_793103_8 857087.Metme_2681 5.1e-05 45.4 COG3630@1|root,COG3630@2|Bacteria,1NHYS@1224|Proteobacteria,1SGS8@1236|Gammaproteobacteria,1XFR3@135618|Methylococcales 135618|Methylococcales C oxaloacetate decarboxylase gamma chain oadG - 4.1.1.3 ko:K01573 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_gamma k59_793103_9 205918.Psyr_1642 5.09e-67 211.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1Z6VF@136849|Pseudomonas syringae group 1236|Gammaproteobacteria D Maf-like protein yceF GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf k59_793103_10 765911.Thivi_2971 6.66e-313 873.0 COG0480@1|root,COG0480@2|Bacteria,1PMU3@1224|Proteobacteria,1S00P@1236|Gammaproteobacteria,1WXBY@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_370900_1 717606.PaecuDRAFT_3963 2.95e-37 146.0 COG0204@1|root,COG0764@1|root,COG3321@1|root,COG0204@2|Bacteria,COG0764@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins - - - - - - - - - - - - AMP-binding,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_402884_1 469618.FVAG_02472 5.2e-56 184.0 COG4658@1|root,COG4658@2|Bacteria,378EB@32066|Fusobacteria 32066|Fusobacteria C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_402884_2 572544.Ilyop_0018 3.22e-95 291.0 COG4656@1|root,COG4656@2|Bacteria,3791P@32066|Fusobacteria 32066|Fusobacteria C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4,Fer4_10,Fer4_17,Fer4_4,Fer4_7,RnfC_N,SLBB k59_860287_1 713586.KB900536_gene1763 1.07e-63 209.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WX0Q@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_729151_1 4113.PGSC0003DMT400089450 4.58e-49 162.0 2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GWDE@35493|Streptophyta,44U28@71274|asterids 35493|Streptophyta - - - - - - - - - - - - - - - k59_402887_1 1121033.AUCF01000032_gene2627 4.96e-92 288.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_998788_1 234831.PSM_A0099 0.000408 39.7 2DQEA@1|root,3369X@2|Bacteria,1NDK6@1224|Proteobacteria,1SE34@1236|Gammaproteobacteria,2Q3K0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Prokaryotic lipoprotein-attachment site - - - - - - - - - - - - LPAM_2 k59_998788_2 243233.MCA0858 1.3e-61 201.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1XDQE@135618|Methylococcales 135618|Methylococcales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_48480_1 1379698.RBG1_1C00001G0393 1.1e-23 103.0 COG0472@1|root,COG0472@2|Bacteria,2NNQW@2323|unclassified Bacteria 2|Bacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 k59_48480_2 1123376.AUIU01000016_gene207 1.66e-59 204.0 COG0772@1|root,COG0772@2|Bacteria,3J0M8@40117|Nitrospirae 40117|Nitrospirae D Cell cycle protein ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_48480_3 1122947.FR7_3221 0.000199 43.1 COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,4H294@909932|Negativicutes 909932|Negativicutes M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_441741_1 1537917.JU82_01650 2.83e-198 567.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2YMB2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_639306_1 1122222.AXWR01000002_gene2188 4.08e-06 54.3 COG4221@1|root,COG4221@2|Bacteria,1WID9@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_672436_1 1121405.dsmv_1054 7.13e-19 86.7 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2WJ06@28221|Deltaproteobacteria,2MHZ7@213118|Desulfobacterales 28221|Deltaproteobacteria H TIGRFAM molybdenum cofactor synthesis domain - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_474902_2 983328.AFGH01000005_gene998 4.29e-50 172.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,42MCZ@68525|delta/epsilon subdivisions,2YMYT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M type I secretion membrane fusion protein, HlyD family - - - ko:K12542,ko:K16300 - M00330,M00571 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1,8.A.1.3.3 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_798702_1 762984.HMPREF9445_01397 4e-116 344.0 COG0541@1|root,COG0541@2|Bacteria,4NDZ2@976|Bacteroidetes,2FNSI@200643|Bacteroidia,4AKKU@815|Bacteroidaceae 976|Bacteroidetes U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_900187_1 439235.Dalk_2831 3.33e-33 130.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_573731_1 613026.HRAG_01435 1.9e-21 100.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2YMTD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the FtsK SpoIIIE SftA family ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_12399_1 326298.Suden_0021 1.26e-73 230.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,42P1T@68525|delta/epsilon subdivisions,2YMMQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_377299_1 743721.Psesu_1900 3.19e-73 239.0 COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X3WH@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_214691_1 1131812.JQMS01000001_gene2086 3.2e-68 232.0 COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,1I0YR@117743|Flavobacteriia,2NV8E@237|Flavobacterium 976|Bacteroidetes G Pfam Glycosyl hydrolases family 2, sugar binding domain - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_106,Glyco_hydro_2_N k59_474913_1 285535.JOEY01000090_gene7680 2.22e-31 124.0 2EXVQ@1|root,33R4U@2|Bacteria 2|Bacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_965563_1 1123008.KB905694_gene1699 1.72e-25 108.0 COG1475@1|root,COG1475@2|Bacteria,4NFZ9@976|Bacteroidetes,2FP81@200643|Bacteroidia,22WNK@171551|Porphyromonadaceae 976|Bacteroidetes K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_735716_1 1316936.K678_05006 2e-97 297.0 COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales 204441|Rhodospirillales Q Homospermidine synthase hss - 2.5.1.44 ko:K00808 ko00960,ko01110,map00960,map01110 - R00018 RC00053 ko00000,ko00001,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_48505_1 931276.Cspa_c16140 7.9e-64 206.0 COG0679@1|root,COG0679@2|Bacteria,1V28G@1239|Firmicutes,24H5F@186801|Clostridia,36WSS@31979|Clostridiaceae 186801|Clostridia S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_48505_2 1122173.AXVL01000020_gene2247 5.69e-84 261.0 COG2723@1|root,COG2723@2|Bacteria,378ZT@32066|Fusobacteria 32066|Fusobacteria G Belongs to the glycosyl hydrolase 1 family - - 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT1 - Glyco_hydro_1 k59_798738_1 742767.HMPREF9456_01768 6.26e-109 337.0 COG3459@1|root,COG3459@2|Bacteria,4NIVN@976|Bacteroidetes,2FQ10@200643|Bacteroidia,22ZKS@171551|Porphyromonadaceae 976|Bacteroidetes G Glycosyl hydrolase 36 superfamily, catalytic domain cepA - 2.4.1.20 ko:K00702 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000 - GT36 - Glyco_hydro_36,Glyco_transf_36 k59_115953_1 1168034.FH5T_07840 2.44e-125 364.0 COG2255@1|root,COG2255@2|Bacteria,4NEB9@976|Bacteroidetes,2FNZB@200643|Bacteroidia 976|Bacteroidetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_509468_1 765910.MARPU_06230 1.9e-53 187.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_441764_1 999541.bgla_1g04850 9.94e-64 201.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,1K0P4@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family paaF - 4.2.1.17 ko:K01692,ko:K01715 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_933451_1 909663.KI867150_gene488 9.8e-45 163.0 COG2197@1|root,COG2197@2|Bacteria,1R3YQ@1224|Proteobacteria,42N0Q@68525|delta/epsilon subdivisions,2WM6W@28221|Deltaproteobacteria 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,PAS_4,PAS_9 k59_246339_1 749414.SBI_09142 9.49e-52 185.0 COG5297@1|root,COG5297@2|Bacteria,2I3VN@201174|Actinobacteria 201174|Actinobacteria G Glycosyl hydrolase family 65, N-terminal domain - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - CBM_2,Glyco_hyd_65N_2 k59_573767_1 519989.ECTPHS_07416 9.38e-52 173.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales 135613|Chromatiales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_573767_2 1117314.PCIT_21349 3.21e-29 112.0 COG0526@1|root,COG0526@2|Bacteria,1QGQ2@1224|Proteobacteria,1TE5A@1236|Gammaproteobacteria,2Q2VE@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_866981_1 754436.JCM19237_750 3.42e-31 117.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1XSWM@135623|Vibrionales 135623|Vibrionales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_48513_2 888055.HMPREF9015_01461 6e-65 220.0 COG0542@1|root,COG0542@2|Bacteria,3793D@32066|Fusobacteria 32066|Fusobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1030248_1 1168034.FH5T_00915 6.88e-46 158.0 COG0477@1|root,COG2814@2|Bacteria,4NG6X@976|Bacteroidetes,2FMDN@200643|Bacteroidia 976|Bacteroidetes EGP Psort location CytoplasmicMembrane, score bcr - - ko:K03446,ko:K07552 - M00701 - - ko00000,ko00002,ko02000 2.A.1.2,2.A.1.3 - - MFS_1 k59_1030248_2 1168034.FH5T_00905 7.14e-47 156.0 COG1051@1|root,COG1051@2|Bacteria,4NIBP@976|Bacteroidetes,2G31H@200643|Bacteroidia 976|Bacteroidetes F Hydrolase, NUDIX family - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_573773_1 1121403.AUCV01000008_gene1543 1.18e-22 101.0 COG0438@1|root,COG0438@2|Bacteria,1R2HF@1224|Proteobacteria,43DDY@68525|delta/epsilon subdivisions,2X8JT@28221|Deltaproteobacteria 28221|Deltaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_377339_1 243159.AFE_0115 3.23e-43 159.0 COG3015@1|root,COG3126@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3126@2|Bacteria,COG3187@2|Bacteria,1NZ8R@1224|Proteobacteria,1S0ZA@1236|Gammaproteobacteria 1236|Gammaproteobacteria MP Copper homeostasis cutF GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0010810,GO:0016020,GO:0019867,GO:0030155,GO:0030312,GO:0030313,GO:0031975,GO:0042802,GO:0044462,GO:0044464,GO:0050789,GO:0065007,GO:0071944 - ko:K06079 ko01503,map01503 - - - ko00000,ko00001 - - - META,NlpE,NlpE_C k59_474937_1 177437.HRM2_37700 3.18e-82 251.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,42NS5@68525|delta/epsilon subdivisions,2WNQ5@28221|Deltaproteobacteria,2MJ7B@213118|Desulfobacterales 28221|Deltaproteobacteria Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_1030256_1 929558.SMGD1_1248 5.33e-67 214.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2YM9J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_149552_1 225117.XP_009350076.1 1.39e-115 362.0 COG0050@1|root,COG0480@1|root,KOG0460@2759|Eukaryota,KOG0465@2759|Eukaryota,37K55@33090|Viridiplantae,3G82M@35493|Streptophyta,4JJGU@91835|fabids 35493|Streptophyta J Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_509501_2 709032.Sulku_1510 1.34e-123 364.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,42MHB@68525|delta/epsilon subdivisions,2YNUZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase cofactor biosynthesis protein NifB - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_866994_1 980584.AFPB01000117_gene2923 2.7e-59 196.0 COG0055@1|root,COG0055@2|Bacteria,4NF1Q@976|Bacteroidetes,1HWM2@117743|Flavobacteriia,405WJ@61432|unclassified Flavobacteriaceae 976|Bacteroidetes C ATP synthase alpha/beta chain, C terminal domain atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_866994_2 746697.Aeqsu_1359 3.89e-27 100.0 COG0355@1|root,COG0355@2|Bacteria,4NUYG@976|Bacteroidetes,1I5R2@117743|Flavobacteriia 976|Bacteroidetes C COG0355 F0F1-type ATP synthase epsilon subunit (mitochondrial delta subunit) atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_277522_1 269797.Mbar_A3217 1.08e-60 198.0 COG0675@1|root,arCOG00684@2157|Archaea,2XSWB@28890|Euryarchaeota,2NBGF@224756|Methanomicrobia 224756|Methanomicrobia L Probable transposase - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_639340_1 749222.Nitsa_0030 1.86e-41 145.0 COG0421@1|root,COG0421@2|Bacteria,1PD55@1224|Proteobacteria,42UAB@68525|delta/epsilon subdivisions,2YPTY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_441809_1 713586.KB900536_gene2577 1.73e-13 75.5 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,1WX6D@135613|Chromatiales 135613|Chromatiales KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_639344_1 1168034.FH5T_11730 3.88e-42 147.0 COG0337@1|root,COG0337@2|Bacteria,4NGSS@976|Bacteroidetes,2FNVM@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_639344_2 1168034.FH5T_11735 2.64e-63 204.0 COG0128@1|root,COG0128@2|Bacteria,4NE8T@976|Bacteroidetes,2FNY8@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_834791_1 1249627.D779_1779 1.41e-15 81.6 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales 135613|Chromatiales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_149577_1 1123315.AUIP01000009_gene805 8.15e-09 56.2 COG2352@1|root,COG2352@2|Bacteria,1TQB6@1239|Firmicutes,4HCAF@91061|Bacilli 91061|Bacilli H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_606830_1 1168034.FH5T_12385 2.34e-90 290.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,4NEDE@976|Bacteroidetes,2FKZJ@200643|Bacteroidia 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_509523_1 596153.Alide_3386 1.81e-45 164.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,4ABEA@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Fer4_4,Fer4_6,Fer4_7 k59_541677_1 768706.Desor_3008 8.94e-11 62.4 COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,1TW0W@1239|Firmicutes,248VM@186801|Clostridia,260VK@186807|Peptococcaceae 186801|Clostridia G Pyruvate phosphate dikinase, PEP pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_541677_2 1191523.MROS_2024 5.33e-52 176.0 COG0334@1|root,COG0334@2|Bacteria 2|Bacteria E glutamate dehydrogenase [NAD(P)+] activity gdhA - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_246386_2 519989.ECTPHS_09033 1.81e-99 295.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,1WWBK@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_12471_1 862908.BMS_2142 2.17e-29 119.0 COG0276@1|root,COG0477@1|root,COG0276@2|Bacteria,COG2814@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2MURR@213481|Bdellovibrionales,2X5EE@28221|Deltaproteobacteria 213481|Bdellovibrionales EGHP Catalyzes the ferrous insertion into protoporphyrin IX hemH - - - - - - - - - - - Ferrochelatase,MFS_1 k59_82899_1 243233.MCA1233 3.13e-118 342.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1XETJ@135618|Methylococcales 135618|Methylococcales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_82899_2 396588.Tgr7_2226 1.23e-99 295.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WW37@135613|Chromatiales 135613|Chromatiales O Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_82899_3 1249627.D779_1777 1.21e-10 70.1 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1WW2G@135613|Chromatiales 135613|Chromatiales D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri,YfiO k59_82899_4 323261.Noc_0146 2.23e-46 157.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1WYG6@135613|Chromatiales 135613|Chromatiales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_82899_5 1049564.TevJSym_be00170 4.78e-118 358.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1J4F8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in the TonB-independent uptake of proteins tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019904,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_82899_6 1260251.SPISAL_02095 8.96e-13 74.3 COG0810@1|root,COG0810@2|Bacteria,1RKRA@1224|Proteobacteria,1S6QG@1236|Gammaproteobacteria,1X2NB@135613|Chromatiales 135613|Chromatiales M Tol-Pal system TolA - - - ko:K03646 - - - - ko00000,ko02000 2.C.1.2 - - TonB_2 k59_82899_7 1026882.MAMP_00018 8.97e-45 150.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,46135@72273|Thiotrichales 72273|Thiotrichales U Biopolymer transport protein ExbD TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_82899_8 765912.Thimo_0571 1.12e-98 293.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1WWA0@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_82899_9 1049564.TevJSym_be00120 1.25e-49 165.0 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1J6J3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Thioesterase superfamily ybgC GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0016790 3.1.2.23 ko:K01075,ko:K07107 ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120 - R01301 RC00004,RC00174 ko00000,ko00001,ko01000 - - iECP_1309.ECP_0747,iSDY_1059.SDY_0684 4HBT k59_82899_10 187272.Mlg_2777 6.34e-183 516.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_835324_2 1121448.DGI_2230 3.37e-22 92.4 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,42SM1@68525|delta/epsilon subdivisions,2WP4T@28221|Deltaproteobacteria,2MBYM@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Phosphoglycerate mutase - - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_311595_1 1537917.JU82_03610 1.29e-38 134.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2YMVJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_311595_2 1537917.JU82_08440 9.7e-45 158.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2YM8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.5.1 ko:K05922 - - - - ko00000,ko01000 - - - NiFeSe_Hases k59_835325_2 1185766.DL1_16695 1.33e-153 436.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,2XKI8@285107|Thioclava 28211|Alphaproteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32,rve,rve_3 k59_346554_2 909663.KI867150_gene556 1.69e-65 207.0 COG1908@1|root,COG2878@1|root,COG1908@2|Bacteria,COG2878@2|Bacteria,1R93S@1224|Proteobacteria,42QKE@68525|delta/epsilon subdivisions,2WMF5@28221|Deltaproteobacteria,2MR57@213462|Syntrophobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - Fer4,FlpD k59_215237_1 1168034.FH5T_18405 3.23e-107 319.0 COG1883@1|root,COG1883@2|Bacteria,4NH3V@976|Bacteroidetes,2FMSY@200643|Bacteroidia 976|Bacteroidetes C decarboxylase beta subunit oadB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_116451_1 1519464.HY22_08540 3.83e-55 181.0 COG2819@1|root,COG2819@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - - - - - - - - - - - Esterase k59_116451_2 1123253.AUBD01000016_gene1984 1.97e-27 109.0 COG2211@1|root,COG2211@2|Bacteria,1MX4Z@1224|Proteobacteria,1RRNW@1236|Gammaproteobacteria,1X5B8@135614|Xanthomonadales 1236|Gammaproteobacteria G Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_189224_1 929558.SMGD1_2790 8.74e-64 211.0 COG3400@1|root,COG3400@2|Bacteria,1N5T1@1224|Proteobacteria,42M0B@68525|delta/epsilon subdivisions,2YMCG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S domain protein - - - ko:K09944 - - - - ko00000 - - - TrkA_C k59_679569_1 118005.AWNK01000007_gene688 1.31e-25 104.0 COG0702@1|root,COG0702@2|Bacteria 2|Bacteria GM epimerase ybjT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF2867,NAD_binding_10,TspO_MBR k59_679569_2 1117647.M5M_17235 2.71e-11 63.2 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,1RQKK@1236|Gammaproteobacteria,1J8RF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_805699_1 1295642.H839_06989 8.71e-75 236.0 COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,4HCIM@91061|Bacilli,1WG79@129337|Geobacillus 91061|Bacilli G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) iolE - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_805699_2 929506.CbC4_1946 3.81e-136 397.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia,36H58@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_646461_2 642492.Clole_0902 1.08e-11 66.6 COG1595@1|root,COG1595@2|Bacteria,1V8GV@1239|Firmicutes,24JEH@186801|Clostridia 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_646463_1 439235.Dalk_5089 1.9e-87 275.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.6.5.3 ko:K00124,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_156871_1 335543.Sfum_1609 1.06e-84 268.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MQAN@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM ribonuclease, Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_449163_1 765911.Thivi_2999 7.25e-85 265.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1WVY3@135613|Chromatiales 135613|Chromatiales S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_742450_2 1094980.Mpsy_0886 2.34e-92 281.0 COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,2N9D4@224756|Methanomicrobia 224756|Methanomicrobia J An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_123078_1 1168034.FH5T_11940 3.65e-60 189.0 COG1610@1|root,COG1610@2|Bacteria,4NQFI@976|Bacteroidetes,2FN46@200643|Bacteroidia 976|Bacteroidetes S YqeY-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_711261_1 1288826.MSNKSG1_14162 7.24e-50 167.0 COG2040@1|root,COG2040@2|Bacteria,1MUXU@1224|Proteobacteria,1SBT6@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG2040 Homocysteine selenocysteine methylase (S-methylmethionine-dependent) - - 2.1.1.10 ko:K00547 ko00270,ko01100,ko01110,map00270,map01100,map01110 - R00650 RC00003,RC00035 ko00000,ko00001,ko01000 - - - S-methyl_trans k59_711261_2 1121374.KB891576_gene623 1.18e-09 56.2 COG4807@1|root,COG4807@2|Bacteria,1RD33@1224|Proteobacteria,1S3ZU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yehS - - - - - - - - - - - DUF1456 k59_253374_1 1384056.N787_06945 4.26e-39 137.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X5Z6@135614|Xanthomonadales 135614|Xanthomonadales O cytochrome c oxidase assembly protein cox11 - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_284390_1 485917.Phep_2787 7e-81 266.0 COG5434@1|root,COG5434@2|Bacteria,4NE4H@976|Bacteroidetes,1IQG1@117747|Sphingobacteriia 976|Bacteroidetes M Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - - k59_548612_1 1288494.EBAPG3_21040 8.66e-38 143.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VHNB@28216|Betaproteobacteria,371VU@32003|Nitrosomonadales 28216|Betaproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_548613_1 1416760.AYMS01000009_gene311 3.15e-28 112.0 COG0520@1|root,COG0520@2|Bacteria,4NDUB@976|Bacteroidetes,1HWSI@117743|Flavobacteriia,47HWQ@76831|Myroides 976|Bacteroidetes E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_548613_2 869213.JCM21142_93584 4.01e-31 114.0 COG1592@1|root,COG1592@2|Bacteria,4NH0J@976|Bacteroidetes 976|Bacteroidetes C Rubrerythrin rbr GO:0003674,GO:0005488,GO:0005506,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050896 - - - - - - - - - - Rubrerythrin k59_221541_1 563040.Saut_0546 1.33e-38 135.0 2AIHQ@1|root,318ZM@2|Bacteria,1Q19H@1224|Proteobacteria,42T48@68525|delta/epsilon subdivisions,2YPGP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_221541_2 1537917.JU82_03710 6.19e-26 107.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2YMRR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3 k59_353312_1 998674.ATTE01000001_gene2376 8.61e-49 167.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,45ZQT@72273|Thiotrichales 72273|Thiotrichales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - - - - - - - - - - - DAHP_synth_1 k59_581447_1 2340.JV46_28240 2.52e-62 216.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_842110_1 387093.SUN_1953 5.3e-13 70.1 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2YMMU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_842110_2 1408439.JHXW01000012_gene833 3.25e-06 50.4 COG2264@1|root,COG2264@2|Bacteria,378I4@32066|Fusobacteria 32066|Fusobacteria J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_680168_1 929558.SMGD1_1169 3.88e-14 70.1 COG4244@1|root,COG4244@2|Bacteria,1PJNV@1224|Proteobacteria,42TI9@68525|delta/epsilon subdivisions,2YQ43@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Membrane - - - - - - - - - - - - - k59_680168_2 563040.Saut_1625 2.98e-180 511.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2YN91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_189768_1 1128111.HMPREF0870_01700 1.52e-91 277.0 COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,4H1XP@909932|Negativicutes 909932|Negativicutes H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_874591_1 1499967.BAYZ01000115_gene2932 7.02e-92 295.0 COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2NP28@2323|unclassified Bacteria 2|Bacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.1,2.1.2.10,2.2.1.8 ko:K00600,ko:K00605,ko:K18847 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R01221,R02300,R04125,R09099 RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C,SHMT k59_157606_1 472759.Nhal_3801 6.77e-36 130.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1WWCV@135613|Chromatiales 135613|Chromatiales E Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_972983_1 572544.Ilyop_1474 3.48e-178 525.0 COG0553@1|root,COG0553@2|Bacteria,3788I@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Helicase_C,SNF2_N k59_581459_1 1123354.AUDR01000012_gene1670 8.87e-162 462.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,1KRHX@119069|Hydrogenophilales 119069|Hydrogenophilales P Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_285007_1 1168034.FH5T_02630 2.23e-96 298.0 COG0471@1|root,COG0471@2|Bacteria,4NF52@976|Bacteroidetes,2FNWH@200643|Bacteroidia 976|Bacteroidetes P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - CitMHS,TrkA_C k59_20120_1 1131553.JIBI01000002_gene1817 8.18e-38 137.0 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,2VSAZ@28216|Betaproteobacteria,372Z1@32003|Nitrosomonadales 28216|Betaproteobacteria S SURF1-like protein surf1 - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_253930_1 655812.HMPREF0061_1069 9.49e-153 480.0 COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,4HA24@91061|Bacilli,27DF2@186827|Aerococcaceae 91061|Bacilli K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_253930_2 290397.Adeh_0720 5.25e-84 275.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2WJ9Y@28221|Deltaproteobacteria,2YUT2@29|Myxococcales 28221|Deltaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_874604_1 326298.Suden_0864 3.32e-126 375.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2YN0E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the UbiD family menA - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0396 UbiD k59_189782_1 382245.ASA_3262 2.84e-65 211.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1Y51Z@135624|Aeromonadales 135624|Aeromonadales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_481934_1 1223410.KN050846_gene1797 6.01e-91 276.0 COG0322@1|root,COG0322@2|Bacteria,4NGEV@976|Bacteroidetes,1HY6H@117743|Flavobacteriia 976|Bacteroidetes L Domain of unknown function (DUF4837) - - - - - - - - - - - - DUF4837 k59_449909_1 1026882.MAMP_00438 9.16e-84 263.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,4603K@72273|Thiotrichales 72273|Thiotrichales O magnesium chelatase - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_874606_1 679935.Alfi_1154 3.06e-07 56.2 COG0542@1|root,COG0542@2|Bacteria,4NGEM@976|Bacteroidetes,2FM5N@200643|Bacteroidia,22UVR@171550|Rikenellaceae 976|Bacteroidetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_806250_1 768671.ThimaDRAFT_4706 2.22e-199 563.0 COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WX18@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_157630_1 243233.MCA1845 1.12e-111 350.0 COG4457@1|root,COG4457@2|Bacteria,1MVRQ@1224|Proteobacteria,1RPSQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Virulence srfB - - - - - - - - - - - SrfB k59_549290_1 929558.SMGD1_1224 1.52e-64 213.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42NYV@68525|delta/epsilon subdivisions,2YN1D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1006238_1 1408473.JHXO01000010_gene3500 2.63e-94 299.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,2FMFA@200643|Bacteroidia 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_806251_1 76114.ebA3127 2.53e-19 88.6 COG4313@1|root,COG4313@2|Bacteria,1QQK2@1224|Proteobacteria,2W9IE@28216|Betaproteobacteria,2KYG8@206389|Rhodocyclales 206389|Rhodocyclales C Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_517582_1 472759.Nhal_3091 9.1e-125 377.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1WXBI@135613|Chromatiales 135613|Chromatiales S oligopeptide transporter - - - - - - - - - - - - OPT k59_517582_2 448385.sce5088 1.18e-54 188.0 COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,437WG@68525|delta/epsilon subdivisions,2X364@28221|Deltaproteobacteria,2YUG4@29|Myxococcales 28221|Deltaproteobacteria E Angiotensin-converting enzyme - - 3.4.15.1 ko:K01283 ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - Peptidase_M2 k59_91026_1 387093.SUN_2226 1.79e-47 171.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4_10,Molybdopterin,NADH-G_4Fe-4S_3 k59_91026_2 1172190.M947_04170 2.09e-10 60.8 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 k59_123746_1 1124780.ANNU01000038_gene206 7.4e-44 163.0 COG1629@1|root,COG1629@2|Bacteria,4P4MW@976|Bacteroidetes,47JAS@768503|Cytophagia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug k59_907612_1 1123400.KB904749_gene726 3.08e-46 172.0 COG4188@1|root,COG4188@2|Bacteria,1QUVG@1224|Proteobacteria,1T22C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1073 Hydrolases of the alpha beta superfamily - - - - - - - - - - - - Lipase_bact_N,PAF-AH_p_II k59_20161_1 349106.PsycPRwf_0487 9.53e-15 74.3 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,3NJDI@468|Moraxellaceae 1236|Gammaproteobacteria C 4Fe-4S single cluster domain epmB GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016866,GO:0016869,GO:0048037,GO:0051536,GO:0051539,GO:0051540 5.4.3.2 ko:K01843,ko:K19810 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000,ko03012 - - iECH74115_1262.ECH74115_5662,iECIAI39_1322.ECIAI39_4611,iS_1188.S4569 Fer4_12,Fer4_14,Radical_SAM k59_20161_2 1168065.DOK_11359 1.07e-16 81.6 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria,1J70G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_55963_1 1168034.FH5T_09195 4.61e-59 202.0 COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,2FM1K@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug k59_55963_2 1416760.AYMS01000033_gene1425 6.54e-18 77.8 COG3682@1|root,COG3682@2|Bacteria,4NT4V@976|Bacteroidetes,1I2YY@117743|Flavobacteriia,47I5W@76831|Myroides 976|Bacteroidetes K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R k59_253957_1 880070.Cycma_3314 1.49e-13 67.0 2ESY9@1|root,33KGI@2|Bacteria,4NZFJ@976|Bacteroidetes,47T07@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_253957_2 927658.AJUM01000022_gene1018 2.03e-82 264.0 COG3182@1|root,COG3182@2|Bacteria,4NJ7N@976|Bacteroidetes,2FPKX@200643|Bacteroidia,3XKDY@558415|Marinilabiliaceae 976|Bacteroidetes S PepSY domain protein - - - - - - - - - - - - PepSY_TM k59_353360_1 1122604.JONR01000006_gene2711 1.33e-90 273.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,1X33N@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_157661_1 1502852.FG94_01329 2.22e-76 244.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,473XB@75682|Oxalobacteraceae 28216|Betaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_549308_1 926569.ANT_00930 4.15e-52 182.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4,Peptidase_S15 k59_973030_1 1417296.U879_20705 1.04e-46 158.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,2UIT4@28211|Alphaproteobacteria 28211|Alphaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_517607_1 1042377.AFPJ01000028_gene2288 5.53e-87 274.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria,466AY@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_7 k59_91051_1 768671.ThimaDRAFT_2147 4.31e-31 117.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,1WX0R@135613|Chromatiales 135613|Chromatiales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_91051_2 768671.ThimaDRAFT_2148 5.87e-76 231.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1WWV2@135613|Chromatiales 135613|Chromatiales I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_581516_1 1335757.SPICUR_05250 2.41e-94 285.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1WXPM@135613|Chromatiales 135613|Chromatiales S PFAM Alcohol dehydrogenase - - - ko:K12957,ko:K13979 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_318289_1 388413.ALPR1_10875 7.6e-55 180.0 2AECJ@1|root,31473@2|Bacteria,4NZDM@976|Bacteroidetes 976|Bacteroidetes S Ion channel - - - - - - - - - - - - Ion_trans_2 k59_222182_1 1121396.KB893117_gene3116 1.22e-39 139.0 COG1227@1|root,COG1227@2|Bacteria,1P9JN@1224|Proteobacteria,42N0W@68525|delta/epsilon subdivisions,2WK0Q@28221|Deltaproteobacteria,2MI41@213118|Desulfobacterales 28221|Deltaproteobacteria C DHHA2 ppaC - 3.6.1.1 ko:K15986 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - CBS,DHH,DHHA2,DRTGG k59_222182_2 1121396.KB892913_gene177 6.54e-09 55.8 COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,42QXT@68525|delta/epsilon subdivisions,2WN0R@28221|Deltaproteobacteria,2MJ9Y@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the SfsA family sfsA - - ko:K06206 - - - - ko00000 - - - SfsA k59_416877_1 1249480.B649_01445 6.04e-96 309.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2YMJS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,NIT,Response_reg k59_1038201_1 1235798.C817_00508 1.74e-10 61.6 28JTN@1|root,2Z9IV@2|Bacteria,1V2P2@1239|Firmicutes,24GDH@186801|Clostridia,27WV9@189330|Dorea 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_385373_1 396588.Tgr7_0356 1.12e-87 271.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_907632_1 203122.Sde_0066 6.94e-59 189.0 COG0328@1|root,COG3341@1|root,COG0328@2|Bacteria,COG3341@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,4676A@72275|Alteromonadaceae 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Cauli_VI,RNase_H k59_1006268_1 1380354.JIAN01000006_gene730 1.35e-125 367.0 COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4F0DY@85016|Cellulomonadaceae 201174|Actinobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_517620_1 1249627.D779_2730 2.96e-101 319.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_842178_1 760192.Halhy_4061 1.55e-11 69.7 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1IW4Z@117747|Sphingobacteriia 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_353383_1 1123261.AXDW01000015_gene3483 3.94e-54 183.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RREX@1236|Gammaproteobacteria,1X3WI@135614|Xanthomonadales 135614|Xanthomonadales C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - - - - - - - - - - E1_dh,OxoDH_E1alpha_N k59_157696_1 1318628.MARLIPOL_10686 4e-39 152.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1T2N0@1236|Gammaproteobacteria,46CXX@72275|Alteromonadaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF,MASE4,PAS_3,Y_Y_Y,dCache_1 k59_157696_2 563040.Saut_0685 7.69e-14 70.1 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,42MH0@68525|delta/epsilon subdivisions,2YMHS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_1011755_1 642492.Clole_3805 8.93e-07 56.6 COG4485@1|root,COG5617@1|root,COG4485@2|Bacteria,COG5617@2|Bacteria,1VI49@1239|Firmicutes,255EV@186801|Clostridia 186801|Clostridia S Bacterial membrane protein YfhO - - - - - - - - - - - - YfhO k59_323567_1 1158294.JOMI01000004_gene3548 6.15e-73 233.0 COG0719@1|root,COG0719@2|Bacteria,4NFXH@976|Bacteroidetes,2FMUZ@200643|Bacteroidia 976|Bacteroidetes O FeS assembly protein SufB sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_323567_2 216432.CA2559_05515 3.05e-19 79.0 COG0401@1|root,COG0401@2|Bacteria,4NUY1@976|Bacteroidetes,1I50E@117743|Flavobacteriia 976|Bacteroidetes S Proteolipid membrane potential modulator - - - - - - - - - - - - Pmp3 k59_456768_1 388051.AUFE01000004_gene965 5.5e-38 138.0 COG0508@1|root,COG0508@2|Bacteria,1MVDC@1224|Proteobacteria,2VPEK@28216|Betaproteobacteria,1K0K3@119060|Burkholderiaceae 28216|Betaproteobacteria C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_96265_1 96561.Dole_3059 2.49e-139 409.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_620331_1 1121887.AUDK01000015_gene858 1.14e-65 225.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1IJ92@117743|Flavobacteriia 976|Bacteroidetes H Outer membrane receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_422387_1 925775.XVE_2936 1.69e-115 360.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1X3SP@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_26005_1 1122225.AULQ01000002_gene632 5.93e-37 139.0 COG0433@1|root,COG0433@2|Bacteria,4NU1B@976|Bacteroidetes,1I4WR@117743|Flavobacteriia 976|Bacteroidetes T TraM recognition site of TraD and TraG - - - - - - - - - - - - TraG-D_C,TrwB_AAD_bind k59_555623_1 1168034.FH5T_03495 7.46e-46 157.0 COG1705@1|root,COG1705@2|Bacteria,4NEER@976|Bacteroidetes,2FM02@200643|Bacteroidia 976|Bacteroidetes MNU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase lytG - - - - - - - - - - - Glucosaminidase,LysM k59_946910_1 713587.THITH_09435 1.02e-262 733.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales 135613|Chromatiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_946910_2 864051.BurJ1DRAFT_2089 1.22e-18 82.0 COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,1KKWA@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Succinate dehydrogenase hydrophobic membrane anchor protein sdhD - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_946910_3 765910.MARPU_02465 1.15e-09 57.8 COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,1SEBT@1236|Gammaproteobacteria,1WZ6I@135613|Chromatiales 135613|Chromatiales C TIGRFAM Succinate dehydrogenase, cytochrome b556 subunit - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_62046_1 1168034.FH5T_01435 6.45e-98 291.0 COG0775@1|root,COG0775@2|Bacteria,4NQVQ@976|Bacteroidetes 976|Bacteroidetes F Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnB - 3.2.2.26 ko:K11783 ko00130,ko01110,map00130,map01110 - R08587 RC00063,RC00318 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_62046_2 1168034.FH5T_01440 1.41e-98 290.0 COG0302@1|root,COG0302@2|Bacteria,4NFC2@976|Bacteroidetes,2FMYB@200643|Bacteroidia 976|Bacteroidetes H GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_620345_1 946483.Cenrod_1639 1.37e-65 210.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria,4AAC1@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_620345_2 1192124.LIG30_2704 1.88e-16 77.4 COG1309@1|root,COG1309@2|Bacteria,1N014@1224|Proteobacteria,2VVAF@28216|Betaproteobacteria,1K44V@119060|Burkholderiaceae 28216|Betaproteobacteria K regulatory protein TetR - - - - - - - - - - - - TetR_N k59_422396_1 1121405.dsmv_0541 6.07e-66 207.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,42RJX@68525|delta/epsilon subdivisions,2WQNR@28221|Deltaproteobacteria,2MJWZ@213118|Desulfobacterales 28221|Deltaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_748416_1 857087.Metme_1065 6.43e-104 314.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1XE06@135618|Methylococcales 135618|Methylococcales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_26027_1 1209989.TepiRe1_0600 7.33e-53 184.0 COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,42FHK@68295|Thermoanaerobacterales 186801|Clostridia F PFAM formate-tetrahydrofolate ligase FTHFS fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_391974_1 1408473.JHXO01000007_gene872 5.78e-206 584.0 COG1282@1|root,COG1282@2|Bacteria,4NHGZ@976|Bacteroidetes,2FSES@200643|Bacteroidia 976|Bacteroidetes C NADP transhydrogenase pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_487420_1 1345695.CLSA_c07450 3.42e-37 133.0 COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,248UZ@186801|Clostridia,36EJ4@31979|Clostridiaceae 186801|Clostridia ET PFAM Extracellular solute-binding protein, family 3 glnH1 - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_422400_1 765911.Thivi_0266 1.42e-93 287.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria,1WYH5@135613|Chromatiales 135613|Chromatiales S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_391981_1 177437.HRM2_36270 4.31e-62 191.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria,2MK4M@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_391981_2 879212.DespoDRAFT_02462 8.24e-18 79.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2MJKX@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_620347_1 1288826.MSNKSG1_04501 4.37e-150 443.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,4645B@72275|Alteromonadaceae 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_620347_2 870187.Thini_0588 1.83e-55 185.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,45ZUP@72273|Thiotrichales 72273|Thiotrichales E Aminotransferase aspC2 - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_290843_1 83406.HDN1F_35800 2.84e-23 100.0 COG1376@1|root,COG1388@1|root,COG1376@2|Bacteria,COG1388@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1J5RU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M L,D-transpeptidase catalytic domain ycfS GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0034645,GO:0042546,GO:0042597,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070004,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K16291,ko:K19234,ko:K19235,ko:K19236 ko01503,map01503 - - - ko00000,ko00001,ko01002,ko01011 - - - LysM,YkuD k59_290843_2 265072.Mfla_0417 1.97e-46 156.0 COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2VRJE@28216|Betaproteobacteria,2KMUF@206350|Nitrosomonadales 206350|Nitrosomonadales S TPM domain - - - - - - - - - - - - TPM_phosphatase k59_259771_1 572477.Alvin_2626 7.53e-81 241.0 COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,1S26H@1236|Gammaproteobacteria,1WY18@135613|Chromatiales 135613|Chromatiales S PFAM Amino acid-binding ACT - - - - - - - - - - - - ACT k59_259771_2 631362.Thi970DRAFT_00750 1.36e-09 58.2 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,1RQ3D@1236|Gammaproteobacteria,1WWR9@135613|Chromatiales 135613|Chromatiales H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_620349_1 1123326.JFBL01000022_gene2633 5.13e-95 295.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2YP81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_880241_1 674977.VMC_01070 4.99e-56 187.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XSJM@135623|Vibrionales 135623|Vibrionales M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_717474_1 717785.HYPMC_1789 4.66e-74 241.0 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,3N7RH@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria V membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K05685 ko02010,map02010 M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k59_1044076_1 1168034.FH5T_21745 1.42e-90 286.0 COG1216@1|root,COG1216@2|Bacteria,4NFW5@976|Bacteroidetes,2FQ14@200643|Bacteroidia 976|Bacteroidetes S Glycosyltransferase, group 2 family protein wbbL - - ko:K07011 - - - - ko00000 - - - CoA_binding_3,Glyco_tranf_2_3,Glycos_transf_2 k59_1044077_1 749222.Nitsa_1758 9.62e-102 306.0 COG5557@1|root,COG5557@2|Bacteria,1R54P@1224|Proteobacteria,42N9S@68525|delta/epsilon subdivisions,2YN90@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Polysulphide reductase NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_487445_1 744979.R2A130_1709 8.71e-86 272.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_748458_1 391589.RGAI101_3937 1.48e-43 164.0 COG1352@1|root,COG2201@1|root,COG3852@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG3852@2|Bacteria,1NQTI@1224|Proteobacteria 1224|Proteobacteria NT Chemotaxis - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HWE_HK,HisKA,HisKA_3,PAS_10,PAS_4,PAS_9,Response_reg k59_290860_1 472759.Nhal_2510 2.6e-97 294.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales 135613|Chromatiales C PFAM Alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_290860_2 1123073.KB899243_gene517 8.82e-17 80.1 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria,1X47R@135614|Xanthomonadales 135614|Xanthomonadales S Zn-dependent hydrolases including glyoxylases - - - - - - - - - - - - Lactamase_B k59_96330_1 472759.Nhal_0269 5.96e-78 243.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales 135613|Chromatiales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_748464_1 1249627.D779_2665 1.27e-112 337.0 COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_358976_3 709032.Sulku_1680 4.43e-90 280.0 COG0582@1|root,COG0582@2|Bacteria,1QYDC@1224|Proteobacteria,43CBN@68525|delta/epsilon subdivisions,2YQ27@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L viral genome integration into host DNA - - - - - - - - - - - - Phage_integrase k59_880263_1 1121374.KB891588_gene3305 9.34e-10 60.8 COG3238@1|root,COG3238@2|Bacteria,1N6ZC@1224|Proteobacteria,1SEP3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative inner membrane exporter, YdcZ - - - ko:K09936 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.7.21 - - DMT_YdcZ k59_195993_1 572544.Ilyop_1115 7.71e-91 273.0 COG0774@1|root,COG0774@2|Bacteria,3794N@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_195993_2 572544.Ilyop_1116 1.59e-86 278.0 COG0210@1|root,COG0210@2|Bacteria,378QF@32066|Fusobacteria 32066|Fusobacteria L K03657 DNA helicase II ATP-dependent DNA helicase PcrA pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_812245_1 1500257.JQNM01000014_gene2946 5.55e-88 288.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4B8TD@82115|Rhizobiaceae 28211|Alphaproteobacteria V efflux pump - - - - - - - - - - - - ACR_tran k59_880265_1 765911.Thivi_4466 4.21e-34 126.0 28PZQ@1|root,2ZCIX@2|Bacteria,1RA7M@1224|Proteobacteria,1S25R@1236|Gammaproteobacteria,1WY1B@135613|Chromatiales 135613|Chromatiales S EF hand - - - - - - - - - - - - EF-hand_5 k59_323643_3 749222.Nitsa_1805 1.53e-33 127.0 COG2932@1|root,COG2932@2|Bacteria,1Q2PM@1224|Proteobacteria,42W25@68525|delta/epsilon subdivisions,2YQFU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - Peptidase_S24,Phage_CI_repr k59_323643_4 983328.AFGH01000012_gene966 9.67e-14 67.0 2AJ40@1|root,319NF@2|Bacteria,1Q3BB@1224|Proteobacteria,42X1V@68525|delta/epsilon subdivisions,2YQZS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_323643_5 118173.KB235914_gene2024 1.46e-54 206.0 COG2801@1|root,COG2801@2|Bacteria,1G1WB@1117|Cyanobacteria,1H9SN@1150|Oscillatoriales 1117|Cyanobacteria L PFAM Mu transposase, C-terminal - - - ko:K07497 - - - - ko00000 - - - HTH_23,HTH_Tnp_Mu_1,Mu-transpos_C,rve k59_323643_6 367737.Abu_1689 3.14e-18 82.4 COG2842@1|root,COG2842@2|Bacteria,1R5D4@1224|Proteobacteria,42V7A@68525|delta/epsilon subdivisions 1224|Proteobacteria L AAA domain - - 3.6.1.3 ko:K07132 - - - - ko00000,ko01000 - - - AAA_22 k59_487459_1 765911.Thivi_0004 1.78e-121 359.0 COG0317@1|root,COG0460@1|root,COG0317@2|Bacteria,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_290874_1 631362.Thi970DRAFT_04429 2.12e-127 402.0 COG3264@1|root,COG4942@1|root,COG3264@2|Bacteria,COG4942@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X0ES@135613|Chromatiales 135613|Chromatiales DM PFAM Mechanosensitive ion channel - - - - - - - - - - - - MS_channel,MscS_TM,MscS_porin k59_555686_1 1095743.HMPREF1054_0507 8.56e-06 49.3 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1Y6S7@135625|Pasteurellales 135625|Pasteurellales M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_555686_2 270374.MELB17_19294 2.48e-19 89.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,465HW@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_880271_1 639282.DEFDS_1479 1.29e-26 108.0 COG0767@1|root,COG0767@2|Bacteria,2GFE1@200930|Deferribacteres 200930|Deferribacteres Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_62095_2 1123354.AUDR01000013_gene656 1.75e-39 144.0 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,1KS5M@119069|Hydrogenophilales 119069|Hydrogenophilales T Sigma factor PP2C-like phosphatases - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_457491_1 1168034.FH5T_06805 4.29e-121 364.0 COG0296@1|root,COG0296@2|Bacteria,4NECZ@976|Bacteroidetes,2FMTG@200643|Bacteroidia 976|Bacteroidetes G 1,4-alpha-glucan branching enzyme glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_979484_1 1121324.CLIT_2c00630 7.29e-39 131.0 COG1917@1|root,COG1917@2|Bacteria,1V723@1239|Firmicutes,24K1V@186801|Clostridia 186801|Clostridia S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_359473_1 1121007.AUML01000095_gene1103 9.1e-86 266.0 COG3547@1|root,COG3547@2|Bacteria,4NGED@976|Bacteroidetes,1HYRZ@117743|Flavobacteriia 976|Bacteroidetes L PFAM Transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_96992_2 748280.NH8B_2867 2.15e-30 114.0 COG4891@1|root,COG4891@2|Bacteria,1N4U1@1224|Proteobacteria,2VTZI@28216|Betaproteobacteria,2KT4C@206351|Neisseriales 206351|Neisseriales S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_130147_1 1168034.FH5T_17360 2.67e-118 355.0 COG1022@1|root,COG1022@2|Bacteria,4NEA4@976|Bacteroidetes,2FNK9@200643|Bacteroidia 976|Bacteroidetes I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_913803_1 438753.AZC_1666 7.69e-76 250.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3EY6H@335928|Xanthobacteraceae 28211|Alphaproteobacteria T histidine kinase A domain protein cckA - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_620925_1 323261.Noc_0390 2.27e-41 146.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales 135613|Chromatiales GM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_620925_2 754477.Q7C_1770 2.07e-44 162.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,463KB@72273|Thiotrichales 72273|Thiotrichales M PFAM Transglycosylase SLT domain - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_488159_1 326298.Suden_2040 1.41e-18 86.3 COG1538@1|root,COG1538@2|Bacteria,1QNYC@1224|Proteobacteria,42TDW@68525|delta/epsilon subdivisions,2YPR5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_488159_2 326298.Suden_2041 9.78e-08 55.5 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2YMYW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_947508_1 251221.35213098 3.49e-24 96.3 COG0724@1|root,COG0724@2|Bacteria,1G7Q7@1117|Cyanobacteria 1117|Cyanobacteria S PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) rbpD - - - - - - - - - - - RRM_1 k59_26592_1 497964.CfE428DRAFT_1385 4.16e-166 482.0 COG3344@1|root,COG3344@2|Bacteria,46SUD@74201|Verrucomicrobia 2|Bacteria L Group II intron maturase-specific domain protein - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_457506_1 1307834.BARL01000002_gene1323 6.69e-75 240.0 COG0436@1|root,COG0436@2|Bacteria,1QE0D@1224|Proteobacteria,2U24M@28211|Alphaproteobacteria 28211|Alphaproteobacteria E 'PFAM Aminotransferase class I and II - - 4.1.1.12 ko:K09758 ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230 - R00397,R00863 RC00282,RC00399,RC00400 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_718044_1 1049564.TevJSym_bc00330 3.75e-23 89.7 COG0298@1|root,COG0298@2|Bacteria,1QKV6@1224|Proteobacteria,1SE6V@1236|Gammaproteobacteria 1236|Gammaproteobacteria O TIGRFAM hydrogenase assembly chaperone hypC hupF hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_718044_2 2340.JV46_24310 2.83e-38 133.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564 - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_718044_3 765912.Thimo_2565 9.37e-32 118.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales 135613|Chromatiales KO TIGRFAM Hydrogenase accessory protein HypB - - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_359496_1 886379.AEWI01000002_gene508 2.6e-59 207.0 COG0574@1|root,COG0574@2|Bacteria,4NGSQ@976|Bacteroidetes,2FM60@200643|Bacteroidia,3XJKN@558415|Marinilabiliaceae 976|Bacteroidetes G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_624986_5 765910.MARPU_03670 4.75e-121 350.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1WW17@135613|Chromatiales 135613|Chromatiales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_624986_7 1049564.TevJSym_bu00100 1.68e-113 327.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1J4SH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_624986_8 765912.Thimo_2873 6.63e-44 146.0 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1X2GF@135613|Chromatiales 135613|Chromatiales U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_331179_1 929558.SMGD1_0046 6.26e-15 74.3 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2YN2K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iIT341.HP0867 LpxB k59_331179_2 709032.Sulku_1023 1.15e-41 140.0 COG0526@1|root,COG0526@2|Bacteria,1R1JZ@1224|Proteobacteria,43EIF@68525|delta/epsilon subdivisions,2YTHD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredoxin_7 k59_363525_1 563040.Saut_1650 3.59e-55 180.0 COG0647@1|root,COG0647@2|Bacteria,1PYVR@1224|Proteobacteria,42NA1@68525|delta/epsilon subdivisions,2YMK0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G HAD-superfamily hydrolase, subfamily IIA - - - ko:K02566 - - - - ko00000 - - - Hydrolase_6,Hydrolase_like k59_363525_2 1537917.JU82_06990 9.43e-114 336.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2YNAN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Chorismate mutase prephenate dehydratase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_232856_1 493475.GARC_0278 1.63e-29 119.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,466GP@72275|Alteromonadaceae 1236|Gammaproteobacteria MU Outer membrane efflux protein lprN - - - - - - - - - - - OEP k59_36252_1 709032.Sulku_2272 4.71e-78 236.0 COG0244@1|root,COG0244@2|Bacteria,1RB0Y@1224|Proteobacteria,43B5K@68525|delta/epsilon subdivisions,2YPHB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_36252_2 563040.Saut_0315 4.66e-100 295.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2YMN7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_396295_1 743299.Acife_3131 3.26e-49 168.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,2NDPM@225057|Acidithiobacillales 225057|Acidithiobacillales G Stress responsive A/B Barrel Domain - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - Dabb,F_bP_aldolase k59_821186_1 1121396.KB893106_gene1817 2.26e-69 214.0 COG5433@1|root,COG5433@2|Bacteria,1N4U4@1224|Proteobacteria,42UBV@68525|delta/epsilon subdivisions,2WR52@28221|Deltaproteobacteria,2MKJI@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_265104_1 1165841.SULAR_05123 8.09e-108 319.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2YMIV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_951949_1 715226.ABI_43770 7.25e-22 90.9 COG3152@1|root,COG3152@2|Bacteria,1Q4U3@1224|Proteobacteria,2UNHJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF805) - - - - - - - - - - - - DUF805 k59_853890_1 709032.Sulku_0435 4.84e-154 447.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ5@1224|Proteobacteria,42NJC@68525|delta/epsilon subdivisions,2YMGQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase cosS - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_853890_2 1537917.JU82_08015 5.21e-151 425.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,42MTC@68525|delta/epsilon subdivisions,2YMSX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain cosR - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_232863_1 768671.ThimaDRAFT_0912 9.19e-97 298.0 COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,1RQ8F@1236|Gammaproteobacteria,1X14E@135613|Chromatiales 135613|Chromatiales P Periplasmic copper-binding protein (NosD) - - - ko:K07218 - - - - ko00000 - - - NosD k59_624999_1 768671.ThimaDRAFT_0764 1.61e-102 298.0 COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria,1WWQZ@135613|Chromatiales 135613|Chromatiales C PFAM NADH Ubiquinone - - - - - - - - - - - - Oxidored_q6 k59_624999_2 159087.Daro_0982 1.94e-52 178.0 COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,2KVAX@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the NiFe NiFeSe hydrogenase large subunit family hoxH - 1.12.1.2 ko:K00436 - - R00700 - ko00000,ko01000 - - - NiFeSe_Hases k59_462090_1 926549.KI421517_gene3152 7.19e-63 208.0 COG3250@1|root,COG3250@2|Bacteria,4NHRV@976|Bacteroidetes,47JP4@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - - - - - - - - - - - Glyco_hydro_2_C k59_755427_1 1249627.D779_0428 2.05e-91 293.0 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_527337_1 935567.JAES01000031_gene1200 1.02e-92 279.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1X4HU@135614|Xanthomonadales 135614|Xanthomonadales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_2739_1 563040.Saut_0265 3.02e-111 325.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,42QY6@68525|delta/epsilon subdivisions,2YNYW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the inositol monophosphatase superfamily cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_1017229_1 1168034.FH5T_03865 2.04e-11 64.3 COG2352@1|root,COG2352@2|Bacteria,4NFC0@976|Bacteroidetes,2FSEF@200643|Bacteroidia 976|Bacteroidetes C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_1017229_2 1168034.FH5T_13610 5.54e-146 425.0 COG1233@1|root,COG1233@2|Bacteria,4NF7K@976|Bacteroidetes,2FRUW@200643|Bacteroidia 976|Bacteroidetes Q Flavin containing amine oxidoreductase crtI - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_428562_1 929558.SMGD1_1058 1.58e-54 175.0 COG0622@1|root,COG0622@2|Bacteria,1NPH4@1224|Proteobacteria,42TB8@68525|delta/epsilon subdivisions,2YPHV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Phosphoesterase - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_428562_2 1249480.B649_00635 2.97e-114 334.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,42NGR@68525|delta/epsilon subdivisions,2YMH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_919715_1 351348.Maqu_2139 3.19e-50 180.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,466AN@72275|Alteromonadaceae 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family bepG - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_69249_1 929558.SMGD1_0400 3.63e-64 223.0 COG2199@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2YRBR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,PAS_3,PAS_9,dCache_3 k59_788424_1 393305.YE3218 7.08e-25 100.0 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,41FB6@629|Yersinia 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_788424_2 506534.Rhein_0371 3.21e-22 93.2 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,1X0JR@135613|Chromatiales 135613|Chromatiales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - - - - - - - - - - - Rnf-Nqr k59_364374_3 314278.NB231_08032 6.27e-41 137.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1WYNJ@135613|Chromatiales 135613|Chromatiales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_920504_1 243090.RB2364 4.28e-36 133.0 COG0705@1|root,COG0705@2|Bacteria 2|Bacteria S proteolysis - - - - - - - - - - - - Rhomboid k59_397079_2 1163407.UU7_11090 2.2e-08 59.3 COG1572@1|root,COG1572@2|Bacteria 2|Bacteria NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - CARDB,CUB,DUF5011,Laminin_G_3,Peptidase_C2,Peptidase_C25,Peptidase_S8 k59_659010_3 1156919.QWC_19102 0.000462 43.5 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2VTY8@28216|Betaproteobacteria 28216|Betaproteobacteria J PFAM RNA-binding S4 domain protein hslR - - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_36988_1 1007103.AFHW01000010_gene6075 1.45e-58 209.0 COG0300@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_265805_1 1163617.SCD_n01916 1.09e-28 116.0 COG0845@1|root,COG0845@2|Bacteria,1QN99@1224|Proteobacteria,2VQR3@28216|Betaproteobacteria 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_528180_1 1304885.AUEY01000016_gene3055 6.89e-16 78.6 COG0613@1|root,COG0613@2|Bacteria,1QV9S@1224|Proteobacteria,43BP1@68525|delta/epsilon subdivisions,2X70C@28221|Deltaproteobacteria,2MPJ2@213118|Desulfobacterales 28221|Deltaproteobacteria S SMART phosphoesterase PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_528180_2 1121405.dsmv_1734 1.39e-15 75.1 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,42MIP@68525|delta/epsilon subdivisions,2WNDB@28221|Deltaproteobacteria,2MJYR@213118|Desulfobacterales 28221|Deltaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_789166_1 396588.Tgr7_1564 1.95e-53 178.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_789166_2 626887.J057_14520 2e-23 94.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,467Y1@72275|Alteromonadaceae 1236|Gammaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_886722_1 981384.AEYW01000001_gene1602 9.93e-79 251.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_36992_1 335541.Swol_1574 9.3e-56 193.0 COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,42JI4@68298|Syntrophomonadaceae 186801|Clostridia J SMART Elongator protein 3 MiaB NifB yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_723741_2 869213.JCM21142_215 1.37e-68 216.0 arCOG14808@1|root,308PC@2|Bacteria,4NR4D@976|Bacteroidetes,47PEP@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 k59_985225_1 1121324.CLIT_13c00250 3.04e-69 216.0 COG0765@1|root,COG0765@2|Bacteria,1V280@1239|Firmicutes,25C2S@186801|Clostridia,25RCK@186804|Peptostreptococcaceae 186801|Clostridia P ABC transporter permease tcyB - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_985225_2 1319815.HMPREF0202_02088 3.81e-83 256.0 COG0834@1|root,COG0834@2|Bacteria,378TP@32066|Fusobacteria 32066|Fusobacteria ET Belongs to the bacterial solute-binding protein 3 family - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_985225_3 1105031.HMPREF1141_1089 6.19e-06 52.8 COG0778@1|root,COG0778@2|Bacteria,1V4UA@1239|Firmicutes,24EVR@186801|Clostridia,36G9W@31979|Clostridiaceae 186801|Clostridia C PFAM Nitroreductase - - - - - - - - - - - - Nitroreductase k59_822057_1 439235.Dalk_0047 3.66e-80 256.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2MI8B@213118|Desulfobacterales 28221|Deltaproteobacteria P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_625816_1 1283300.ATXB01000001_gene80 1.36e-10 62.0 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1XF4P@135618|Methylococcales 135618|Methylococcales NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_625816_2 247634.GPB2148_1281 1.64e-13 72.0 COG4967@1|root,COG4967@2|Bacteria,1RK2M@1224|Proteobacteria,1SEYX@1236|Gammaproteobacteria,1J6WU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Pfam:N_methyl_2 - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_691197_2 1168034.FH5T_09380 3.04e-17 80.5 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FWYQ@200643|Bacteroidia 976|Bacteroidetes T Sigma-54 interaction domain - - - - - - - - - - - - Response_reg,Sigma54_activat k59_920521_1 1123256.KB907941_gene114 7.06e-117 368.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X41A@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_886732_2 1298867.AUES01000051_gene4506 3.08e-20 92.0 COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria,3K33G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Peptidase, M50 family - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3,PqqD k59_854705_1 1168034.FH5T_16685 8.85e-117 341.0 COG0705@1|root,COG0705@2|Bacteria,4NGT3@976|Bacteroidetes,2FMIT@200643|Bacteroidia 976|Bacteroidetes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Rhomboid k59_723748_1 1168034.FH5T_20955 4.26e-75 250.0 COG1074@1|root,COG1074@2|Bacteria,4NEX4@976|Bacteroidetes,2FMHG@200643|Bacteroidia 976|Bacteroidetes L Belongs to the helicase family. UvrD subfamily addA - - - - - - - - - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C k59_659025_1 1121447.JONL01000013_gene3686 1.22e-68 228.0 COG3972@1|root,COG3972@2|Bacteria,1R42E@1224|Proteobacteria,42VFZ@68525|delta/epsilon subdivisions,2WU2H@28221|Deltaproteobacteria,2MB05@213115|Desulfovibrionales 28221|Deltaproteobacteria S UvrD-like helicase C-terminal domain - - - - - - - - - - - - UvrD_C_2 k59_463001_1 1234364.AMSF01000034_gene297 2.37e-68 219.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1X3K3@135614|Xanthomonadales 135614|Xanthomonadales M Arabinose 5-phosphate isomerase kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_592676_2 745014.OMB55_00019380 1.27e-10 63.5 2E991@1|root,333HB@2|Bacteria 2|Bacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_37011_1 1168034.FH5T_02855 1.2e-102 308.0 COG0842@1|root,COG0842@2|Bacteria,4NFM0@976|Bacteroidetes,2FMNV@200643|Bacteroidia 976|Bacteroidetes V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_103268_1 1168034.FH5T_04970 5.39e-80 244.0 COG0264@1|root,COG0264@2|Bacteria,4NF03@976|Bacteroidetes,2FNAD@200643|Bacteroidia 976|Bacteroidetes J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_103268_2 1168034.FH5T_04975 7.64e-53 173.0 COG0052@1|root,COG0052@2|Bacteria,4NER0@976|Bacteroidetes,2FM4T@200643|Bacteroidia 976|Bacteroidetes J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_920526_1 1049564.TevJSym_ap00730 1.49e-166 474.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1J4TG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the CarA family carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040 CPSase_sm_chain,GATase k59_429234_1 525904.Tter_0131 2.38e-35 126.0 COG0314@1|root,COG0314@2|Bacteria,2NR4E@2323|unclassified Bacteria 2|Bacteria H MoaE protein moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 ko:K03635,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE,ThiS k59_70028_1 1121875.KB907546_gene2194 3.97e-112 344.0 COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia 976|Bacteroidetes Q PFAM D-aminoacylase, C-terminal region - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_135961_1 870187.Thini_0565 1.19e-140 398.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,46002@72273|Thiotrichales 1224|Proteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050136,GO:0051179,GO:0051234,GO:0051536,GO:0051539,GO:0051540,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iYL1228.KPN_02677 Oxidored_q6 k59_135961_2 156889.Mmc1_2207 1.09e-83 251.0 COG0852@1|root,COG0852@2|Bacteria,1RB4M@1224|Proteobacteria 1224|Proteobacteria C PFAM Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_135961_3 156889.Mmc1_2206 1.07e-250 691.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2UPB5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD2 - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_135961_4 156889.Mmc1_2205 3.32e-296 824.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria 1224|Proteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases bzdV - - - - - - - - - - - Fer2_4,Fer4,Fer4_17,Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_135961_5 1049564.TevJSym_ad00570 7.56e-64 200.0 COG1633@1|root,COG1633@2|Bacteria,1RDK1@1224|Proteobacteria,1S55F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_886744_1 469618.FVAG_02608 5.54e-55 182.0 COG0389@1|root,COG0389@2|Bacteria,378YG@32066|Fusobacteria 32066|Fusobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C k59_397116_1 650150.ERH_1475 1.02e-34 129.0 COG2364@1|root,COG2364@2|Bacteria,1TU29@1239|Firmicutes,3VRNJ@526524|Erysipelotrichia 526524|Erysipelotrichia S Membrane - - - - - - - - - - - - YitT_membrane k59_135967_1 1416752.AYME01000002_gene986 1.42e-24 109.0 COG1361@1|root,COG2304@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,2I8F1@201174|Actinobacteria,4FM8R@85023|Microbacteriaceae 201174|Actinobacteria M oxidoreductase activity - - - - - - - - - - - - DUF11 k59_829404_2 554065.XP_005847732.1 4.34e-20 94.4 COG2819@1|root,2S6N9@2759|Eukaryota,37XBM@33090|Viridiplantae,34J9Z@3041|Chlorophyta 3041|Chlorophyta S Putative esterase - - - - - - - - - - - - CBM53,Esterase k59_7835_1 395495.Lcho_1549 2.71e-101 315.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,1KIYF@119065|unclassified Burkholderiales 28216|Betaproteobacteria O cytochrome C ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_928274_1 1125863.JAFN01000001_gene3082 1.29e-51 171.0 COG0811@1|root,COG0811@2|Bacteria,1RJQC@1224|Proteobacteria,42T3R@68525|delta/epsilon subdivisions,2WPMF@28221|Deltaproteobacteria 28221|Deltaproteobacteria U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_928274_2 1232437.KL662077_gene1849 1.95e-21 87.4 COG4744@1|root,COG4744@2|Bacteria,1N1J3@1224|Proteobacteria,42UV5@68525|delta/epsilon subdivisions,2WQ6I@28221|Deltaproteobacteria,2MM4M@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterized conserved protein (DUF2149) - - - - - - - - - - - - DUF2149 k59_372171_1 1122963.AUHB01000001_gene207 3.4e-34 129.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,36XEZ@31993|Methylocystaceae 28211|Alphaproteobacteria D Iron-sulfur cluster assembly protein mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_959990_1 396588.Tgr7_1585 8.3e-19 85.9 COG1664@1|root,COG1664@2|Bacteria,1ND4H@1224|Proteobacteria,1SF92@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_794032_1 1168034.FH5T_06805 7.83e-156 456.0 COG0296@1|root,COG0296@2|Bacteria,4NECZ@976|Bacteroidetes,2FMTG@200643|Bacteroidia 976|Bacteroidetes G 1,4-alpha-glucan branching enzyme glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_240951_1 1121904.ARBP01000003_gene6497 1.93e-50 164.0 COG1573@1|root,COG1573@2|Bacteria,4NG84@976|Bacteroidetes,47TE4@768503|Cytophagia 976|Bacteroidetes L UreE urease accessory protein, C-terminal domain - - - - - - - - - - - - UDG k59_536185_1 1304880.JAGB01000004_gene1490 3.4e-49 172.0 COG2801@1|root,COG2801@2|Bacteria,1TT8V@1239|Firmicutes,24BFH@186801|Clostridia 186801|Clostridia L PFAM Integrase catalytic - - - - - - - - - - - - HTH_28,HTH_32,rve k59_209052_3 1341151.ASZU01000006_gene2768 2.51e-09 60.8 COG1514@1|root,COG1514@2|Bacteria,1VEU2@1239|Firmicutes,4HPRP@91061|Bacilli,27C48@186824|Thermoactinomycetaceae 91061|Bacilli J AKAP7 2'5' RNA ligase-like domain ytlP - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_144265_1 709032.Sulku_0114 4.65e-57 184.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2YNGY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_43398_1 1123393.KB891333_gene2641 4.2e-101 320.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,1KSFY@119069|Hydrogenophilales 119069|Hydrogenophilales V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_43398_2 56780.SYN_00285 2.23e-08 55.8 COG0845@1|root,COG0845@2|Bacteria,1PZST@1224|Proteobacteria,42R2S@68525|delta/epsilon subdivisions,2WMVJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M TIGRFAM efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_176581_1 1049564.TevJSym_ao00730 5.9e-26 100.0 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1J73I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins mreD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_176581_2 768671.ThimaDRAFT_3992 5.94e-25 105.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_993471_1 1172190.M947_11485 2.29e-29 108.0 COG0848@1|root,COG0848@2|Bacteria,1N9DN@1224|Proteobacteria,42V0H@68525|delta/epsilon subdivisions,2YQ7R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U biopolymer transport protein exbD - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_993471_2 1537917.JU82_08395 8.48e-68 209.0 COG0811@1|root,COG0811@2|Bacteria,1RK2P@1224|Proteobacteria,42TPV@68525|delta/epsilon subdivisions,2YPGE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Biopolymer transporter ExbB - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_340449_1 383372.Rcas_0372 2.93e-89 287.0 COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi,37711@32061|Chloroflexia 32061|Chloroflexia P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_601267_1 1142394.PSMK_30050 1.13e-71 235.0 COG1217@1|root,COG1217@2|Bacteria,2IY3Q@203682|Planctomycetes 203682|Planctomycetes T membrane GTPase involved in stress response typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_960004_1 1168034.FH5T_18295 1.77e-99 297.0 COG0524@1|root,COG0524@2|Bacteria,4NH8K@976|Bacteroidetes,2FM8P@200643|Bacteroidia 976|Bacteroidetes G pfkB family carbohydrate kinase - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_272464_1 1348635.BBJY01000012_gene1154 3.18e-64 200.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1XSIT@135623|Vibrionales 135623|Vibrionales J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_601268_1 1472716.KBK24_0134105 4.91e-73 233.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,1K11P@119060|Burkholderiaceae 28216|Betaproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_536199_1 491952.Mar181_3297 5.89e-89 287.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XHN6@135619|Oceanospirillales 135619|Oceanospirillales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_960006_1 326298.Suden_1666 9.15e-153 436.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2YMCA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Methylenetetrahydrofolate reductase metF - - - - - - - - - - - MTHFR k59_43408_1 1408444.JHYC01000025_gene96 2.18e-24 97.8 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1JCRS@118969|Legionellales 118969|Legionellales D Cellulose biosynthesis protein BcsQ parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_43408_2 323848.Nmul_A2769 2.15e-34 125.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,372DW@32003|Nitrosomonadales 28216|Betaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_698725_1 1255043.TVNIR_3824 5.02e-128 379.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_993477_1 760154.Sulba_1574 4.32e-66 213.0 COG0270@1|root,COG0270@2|Bacteria,1R59Y@1224|Proteobacteria,42Z5R@68525|delta/epsilon subdivisions,2YRE6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_993477_2 1121889.AUDM01000005_gene1750 2.08e-211 598.0 COG3066@1|root,COG3066@2|Bacteria,4NJBM@976|Bacteroidetes,1I0NS@117743|Flavobacteriia,2NYPP@237|Flavobacterium 976|Bacteroidetes L DNA mismatch repair enzyme MutH - - - - - - - - - - - - MutH k59_340462_1 944560.HMPREF9058_1077 5.92e-14 78.6 COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4D387@85005|Actinomycetales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_240969_1 1121296.JONJ01000001_gene1762 5.34e-46 172.0 COG3290@1|root,COG3290@2|Bacteria,1TQNZ@1239|Firmicutes,249FI@186801|Clostridia,220CN@1506553|Lachnoclostridium 186801|Clostridia T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07717 ko02020,map02020 M00518 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c k59_240969_2 1123009.AUID01000016_gene26 3.88e-25 102.0 COG4753@1|root,COG4753@2|Bacteria,1TPFP@1239|Firmicutes,24AIA@186801|Clostridia,26CSQ@186813|unclassified Clostridiales 186801|Clostridia T YcbB domain - - - ko:K07719 ko02020,map02020 M00518 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,YcbB k59_110670_1 709032.Sulku_2246 5.29e-92 280.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2YMI9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_240970_1 395493.BegalDRAFT_0483 1.03e-24 100.0 COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,1SAAR@1236|Gammaproteobacteria,462MM@72273|Thiotrichales 72273|Thiotrichales M PFAM Rickettsia 17 kDa surface antigen - - - - - - - - - - - - 17kDa_Anti_2,Rick_17kDa_Anti k59_240970_2 1121015.N789_02565 3.72e-08 54.3 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1X46Q@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_436458_1 1168034.FH5T_18320 8.19e-81 253.0 COG1757@1|root,COG1757@2|Bacteria,4NFQT@976|Bacteroidetes,2FNIY@200643|Bacteroidia 976|Bacteroidetes C Na H antiporter nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k59_340467_1 264731.PRU_0276 3.38e-14 73.2 COG5297@1|root,COG5297@2|Bacteria,4P0PA@976|Bacteroidetes 976|Bacteroidetes G CotH kinase protein - - - - - - - - - - - - CotH k59_763732_1 591023.AM202_03095 1.1e-106 317.0 2AKRW@1|root,31BIT@2|Bacteria,1RK6Q@1224|Proteobacteria,1S7DH@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_666959_1 1122222.AXWR01000023_gene1558 9.11e-70 223.0 COG0458@1|root,COG0458@2|Bacteria 2|Bacteria F carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity - - - - - - - - - - - - ATP-grasp_4 k59_176614_1 1168034.FH5T_12945 3.17e-71 218.0 COG0203@1|root,COG0203@2|Bacteria,4NNW0@976|Bacteroidetes,2FNPH@200643|Bacteroidia 976|Bacteroidetes J 50S ribosomal protein L17 rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_176614_2 1168034.FH5T_12940 1.36e-24 99.4 COG0202@1|root,COG0202@2|Bacteria,4NE8W@976|Bacteroidetes,2FM4P@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_894952_1 1168034.FH5T_01210 1.24e-101 310.0 COG0795@1|root,COG0795@2|Bacteria,4NE8B@976|Bacteroidetes,2FP6P@200643|Bacteroidia 976|Bacteroidetes S Permease, YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_43423_1 870187.Thini_0203 2.03e-37 144.0 COG4196@1|root,COG4196@2|Bacteria,1R6II@1224|Proteobacteria,1SKHQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - DUF2126 k59_436466_1 765912.Thimo_2444 6.52e-136 398.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1WVV4@135613|Chromatiales 135613|Chromatiales L AAA ATPase, central domain protein - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_993485_2 485913.Krac_0954 4.91e-42 153.0 COG1611@1|root,COG1611@2|Bacteria,2G6IB@200795|Chloroflexi 200795|Chloroflexi S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_993485_3 443254.Marpi_1742 2.57e-36 129.0 COG0691@1|root,COG0691@2|Bacteria,2GCZP@200918|Thermotogae 200918|Thermotogae J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_894955_1 1319815.HMPREF0202_00070 2.06e-53 186.0 COG0010@1|root,COG1982@1|root,COG0010@2|Bacteria,COG1982@2|Bacteria,379MA@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Arginase,OKR_DC_1,OKR_DC_1_C k59_305611_1 1101189.AQUO01000002_gene622 8.92e-101 303.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TTPD@28211|Alphaproteobacteria,2PYAC@265|Paracoccus 28211|Alphaproteobacteria E Glutamine synthetase, catalytic domain glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_240987_1 95619.PM1_0226640 4.73e-25 95.5 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0235 family yggU - - ko:K09131 - - - - ko00000 - - - DUF167 k59_240987_2 765913.ThidrDRAFT_2114 7.38e-66 206.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1WXC6@135613|Chromatiales 135613|Chromatiales S integral membrane protein - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_666975_1 1041138.KB890222_gene685 3.5e-94 288.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,4B93D@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_730524_1 1415778.JQMM01000001_gene1138 5.66e-66 209.0 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_436476_1 1217718.ALOU01000112_gene4314 5.22e-40 146.0 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WB1W@28216|Betaproteobacteria,1K4YH@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_763753_1 991905.SL003B_1384 5.7e-44 164.0 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4BPN0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - 4HB_MCP_1,CHASE4,EAL,GGDEF,PAS_4,PAS_7 k59_633955_1 1163617.SCD_n00372 4.27e-94 288.0 COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria 28216|Betaproteobacteria S cytochrome d1, heme region nirF - - ko:K19345 - - - - ko00000 - - - Cytochrom_D1 k59_209116_1 111780.Sta7437_3828 3.31e-30 108.0 2E3CN@1|root,32YBX@2|Bacteria,1G8Z2@1117|Cyanobacteria,3VKKU@52604|Pleurocapsales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_209116_2 765911.Thivi_1025 1.94e-15 74.7 COG1977@1|root,COG3536@1|root,COG1977@2|Bacteria,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1TKAA@1236|Gammaproteobacteria,1X136@135613|Chromatiales 135613|Chromatiales H Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971,ThiS k59_240989_1 1127673.GLIP_2159 1.84e-31 132.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S876@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_763756_2 1273538.G159_17950 1.37e-49 171.0 COG4134@1|root,COG4134@2|Bacteria,1TR3G@1239|Firmicutes,4HAW1@91061|Bacilli,26H10@186818|Planococcaceae 91061|Bacilli S Bacterial extracellular solute-binding protein - - - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - SBP_bac_8 k59_666979_1 857087.Metme_3699 1.86e-24 93.6 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,1XFPU@135618|Methylococcales 135618|Methylococcales J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_698760_2 882378.RBRH_02130 9.03e-13 68.9 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1K1JT@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_1025038_1 1049564.TevJSym_ao00080 8.19e-92 276.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G sugar kinase adoK - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_7871_1 243233.MCA2174 1.09e-76 239.0 COG0803@1|root,COG0803@2|Bacteria,1RAQU@1224|Proteobacteria 1224|Proteobacteria P Zinc-uptake complex component A periplasmic - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_176637_1 864073.HFRIS_022523 2.75e-19 91.7 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,2VKVU@28216|Betaproteobacteria,473UK@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_633963_1 1168034.FH5T_14750 1.42e-110 331.0 COG1680@1|root,COG1680@2|Bacteria,4NFUI@976|Bacteroidetes 976|Bacteroidetes V Beta-lactamase class C and other penicillin binding - - 3.5.2.6 ko:K01467 ko01501,ko02020,map01501,map02020 M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000 - - - Beta-lactamase k59_209957_1 1165841.SULAR_09604 4.72e-15 74.3 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2YN6C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidase U32 family prtC - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_209957_2 749222.Nitsa_0695 4.31e-58 183.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2YNW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_569172_1 935836.JAEL01000163_gene2322 1.3e-65 216.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4HEIB@91061|Bacilli,1ZEZ9@1386|Bacillus 91061|Bacilli L COG3344 Retron-type reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_177503_1 588581.Cpap_0079 1.58e-63 219.0 COG2227@1|root,COG2230@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG2230@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia 186801|Clostridia Q Beta-ketoacyl synthase - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_78547_1 643648.Slip_1606 3.66e-47 161.0 COG1484@1|root,COG1484@2|Bacteria,1UYIT@1239|Firmicutes,24DFX@186801|Clostridia,42KKU@68298|Syntrophomonadaceae 186801|Clostridia L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_895877_1 87626.PTD2_15217 7.33e-89 273.0 COG1363@1|root,COG1363@2|Bacteria,1MWQV@1224|Proteobacteria,1RRZY@1236|Gammaproteobacteria,2Q1VU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria G peptidase M42 - - - - - - - - - - - - Peptidase_M42 k59_929129_1 1168034.FH5T_12805 7.2e-79 253.0 COG0480@1|root,COG0480@2|Bacteria,4NE9X@976|Bacteroidetes,2FM1M@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_794584_1 1536775.H70737_19810 4.79e-42 154.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,26TD5@186822|Paenibacillaceae 91061|Bacilli G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_794584_2 860228.Ccan_22400 3.35e-09 55.8 COG0637@1|root,COG0637@2|Bacteria,4NEEH@976|Bacteroidetes,1HX4N@117743|Flavobacteriia,1ER30@1016|Capnocytophaga 976|Bacteroidetes S beta-phosphoglucomutase pgmB - 5.4.2.6 ko:K01838 ko00500,map00500 - R02728,R11310 RC00408 ko00000,ko00001,ko01000 - - - HAD_2 k59_994275_1 1123487.KB892834_gene2750 9.68e-11 66.2 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2VKKI@28216|Betaproteobacteria,2KY4W@206389|Rhodocyclales 206389|Rhodocyclales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_862407_2 314278.NB231_10693 2.35e-28 110.0 COG0697@1|root,COG0697@2|Bacteria,1RJFE@1224|Proteobacteria,1RZF0@1236|Gammaproteobacteria,1WWYW@135613|Chromatiales 135613|Chromatiales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_306467_1 742159.HMPREF0004_3969 2.66e-83 257.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,3T1US@506|Alcaligenaceae 28216|Betaproteobacteria M Cyclopropane fatty acid synthase and related methyltransferases cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_306467_2 1384056.N787_05545 5.73e-22 94.4 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1X3N5@135614|Xanthomonadales 135614|Xanthomonadales P antiporter - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_800438_1 243231.GSU2351 2.37e-50 180.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.6 ko:K01535,ko:K12955 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.24,3.A.3.3 - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_347698_1 1165841.SULAR_05483 6.22e-109 333.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2YMMT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_84668_1 1049564.TevJSym_bc00140 1.5e-79 246.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1J5AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG0331 (acyl-carrier-protein) S-malonyltransferase fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598 Acyl_transf_1 k59_641114_2 765914.ThisiDRAFT_2593 3.64e-86 267.0 COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,1S093@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_248177_1 29495.EA26_19255 3.88e-128 371.0 COG3335@1|root,COG3335@2|Bacteria,1N5WI@1224|Proteobacteria,1S5TZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_248177_2 1005058.UMN179_00571 0.000872 40.8 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria,1YAAW@135625|Pasteurellales 135625|Pasteurellales L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_379142_1 1137281.D778_01224 3.48e-74 229.0 COG0790@1|root,COG0790@2|Bacteria,4NGW3@976|Bacteroidetes,1HY27@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF2911) - - - - - - - - - - - - DUF2911 k59_800448_1 981383.AEWH01000044_gene3183 6.09e-07 52.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,4H9U2@91061|Bacilli 91061|Bacilli J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_800448_2 742817.HMPREF9449_01741 5.23e-13 67.4 2ACZI@1|root,312MC@2|Bacteria,4PHKN@976|Bacteroidetes,2G1IY@200643|Bacteroidia,22Z1T@171551|Porphyromonadaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_641126_1 404380.Gbem_3588 1.83e-20 94.0 COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,43BSZ@68525|delta/epsilon subdivisions,2WME9@28221|Deltaproteobacteria 28221|Deltaproteobacteria M FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD k59_411426_1 565045.NOR51B_1466 1.68e-21 94.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminotransferase phhC - 2.6.1.1,2.6.1.57 ko:K00813,ko:K00832 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 M00024,M00025,M00034,M00040 R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_411426_2 904144.AEJD01000006_gene391 2.84e-17 78.6 COG0219@1|root,COG0219@2|Bacteria,2IHN9@201174|Actinobacteria,4CZ0E@85004|Bifidobacteriales 201174|Actinobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily spoU - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_706068_1 709032.Sulku_1605 9.28e-06 46.6 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2YMRT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_706068_2 273121.WS0303 2.94e-38 147.0 COG1538@1|root,COG1538@2|Bacteria,1Q066@1224|Proteobacteria,42RNJ@68525|delta/epsilon subdivisions,2YNZR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_641147_1 1278307.KB907057_gene2644 6.28e-77 242.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,2QJ5B@267894|Psychromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_379150_1 887062.HGR_05434 6.32e-43 152.0 COG4731@1|root,COG4731@2|Bacteria,1RHT2@1224|Proteobacteria,2WIGF@28216|Betaproteobacteria 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2147) - - - - - - - - - - - - - k59_901949_1 305700.B447_21402 1.14e-85 271.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,2VMF3@28216|Betaproteobacteria,2KXTT@206389|Rhodocyclales 206389|Rhodocyclales L COG3436 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_935103_1 1168034.FH5T_04925 5.59e-87 260.0 COG1018@1|root,COG1018@2|Bacteria 2|Bacteria C nitric oxide dioxygenase activity fpr GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364,iYL1228.KPN_04002 FAD_binding_6,NAD_binding_1 k59_935103_2 1168034.FH5T_04930 2.89e-29 108.0 COG4635@1|root,COG4635@2|Bacteria,4PK9I@976|Bacteroidetes,2FZ54@200643|Bacteroidia 976|Bacteroidetes CH Flavodoxin domain - - 1.3.5.3 ko:K00230 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R09489 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Flavodoxin_5 k59_216576_1 237368.SCABRO_00303 3.5e-89 271.0 COG0384@1|root,COG0384@2|Bacteria,2IYZ8@203682|Planctomycetes 203682|Planctomycetes S epimerase, PhzC PhzF homolog - - - - - - - - - - - - PhzC-PhzF k59_216576_2 1168034.FH5T_16285 4.46e-08 54.3 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,SLH,SprB,VCBS k59_151390_1 1122604.JONR01000001_gene1928 4.29e-11 62.0 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S697@1236|Gammaproteobacteria,1X6V2@135614|Xanthomonadales 135614|Xanthomonadales L DNA polymerase III chi subunit, HolC - - - - - - - - - - - - DNA_pol3_chi k59_151390_3 243159.AFE_2204 6.51e-36 135.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,2NCCR@225057|Acidithiobacillales 225057|Acidithiobacillales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_279331_1 870187.Thini_4277 6.55e-24 91.7 COG1942@1|root,COG1942@2|Bacteria 2|Bacteria S isomerase activity dmpI - 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 - - - SnoaL_2,Tautomerase k59_279331_2 402626.Rpic_4623 2.85e-43 146.0 COG3193@1|root,COG3193@2|Bacteria,1RH9E@1224|Proteobacteria,2VT15@28216|Betaproteobacteria,1K7X4@119060|Burkholderiaceae 28216|Betaproteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_279331_3 305700.B447_13354 3.13e-73 230.0 COG0346@1|root,COG0346@2|Bacteria,1MUWY@1224|Proteobacteria,2VKV3@28216|Betaproteobacteria,2KUG0@206389|Rhodocyclales 206389|Rhodocyclales E COG0346 Lactoylglutathione lyase and related lyases - - 1.13.11.2 ko:K00446 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 br01602,ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase k59_411454_1 1168034.FH5T_20635 4.71e-170 490.0 COG1158@1|root,COG1158@2|Bacteria,4NEFP@976|Bacteroidetes,2FN7R@200643|Bacteroidia 976|Bacteroidetes K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_868854_2 123214.PERMA_1700 1.82e-34 120.0 COG0636@1|root,COG0636@2|Bacteria 2|Bacteria C ATP hydrolysis coupled proton transport atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110,ko:K02124 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157,M00159 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1,3.A.2.2,3.A.2.3 - - ATP-synt_C k59_50942_1 981085.XP_010100012.1 6.73e-144 408.0 COG0356@1|root,KOG4665@2759|Eukaryota,37MBD@33090|Viridiplantae,3GH9B@35493|Streptophyta,4JDXB@91835|fabids 35493|Streptophyta C it plays a direct role in the translocation of protons across the membrane atpI GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009544,GO:0009579,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031976,GO:0031984,GO:0032991,GO:0033177,GO:0034220,GO:0034357,GO:0042623,GO:0042625,GO:0042626,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046933,GO:0051179,GO:0051234,GO:0055035,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098807,GO:0099131,GO:0099132,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_348429_1 84531.JMTZ01000010_gene3185 4.89e-14 70.5 COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,1SYQY@1236|Gammaproteobacteria,1X61F@135614|Xanthomonadales 135614|Xanthomonadales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_837224_1 2340.JV46_21420 1.7e-155 449.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1J9E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3318 GDC-P k59_837224_2 1124983.PFLCHA0_c12740 3.34e-09 55.5 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1YQHH@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M Recycling of diacylglycerol produced during the turnover of membrane phospholipid dgkA - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_477335_1 1121447.JONL01000001_gene1077 7.48e-52 188.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2M7RA@213115|Desulfovibrionales 28221|Deltaproteobacteria NT PFAM chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_511948_1 1247649.D560_1068 0.000764 43.9 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,3T1RJ@506|Alcaligenaceae 28216|Betaproteobacteria I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_511948_2 757424.Hsero_0010 1.58e-27 114.0 COG2207@1|root,COG2207@2|Bacteria,1PGUS@1224|Proteobacteria,2W9PE@28216|Betaproteobacteria,477R9@75682|Oxalobacteraceae 28216|Betaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_737961_1 1049564.TevJSym_aa01740 1.58e-66 220.0 COG1226@1|root,COG1226@2|Bacteria 2|Bacteria P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2,Na_H_Exchanger,TrkA_C,TrkA_N k59_50949_1 1168034.FH5T_19615 2.54e-71 215.0 COG0292@1|root,COG0292@2|Bacteria,4NNKU@976|Bacteroidetes,2FSHF@200643|Bacteroidia 976|Bacteroidetes J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_248823_2 96561.Dole_2280 5.67e-38 137.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2WNS9@28221|Deltaproteobacteria,2MJZ8@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM VacJ family lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_869525_1 555088.DealDRAFT_0132 1.16e-13 75.5 COG2271@1|root,COG2271@2|Bacteria,1V0WU@1239|Firmicutes,25E6S@186801|Clostridia 186801|Clostridia G PFAM Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 k59_50956_1 1158756.AQXQ01000009_gene1180 9.63e-85 270.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WY16@135613|Chromatiales 135613|Chromatiales O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_837248_1 925775.XVE_1264 1.16e-75 238.0 COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,1T1KM@1236|Gammaproteobacteria,1X4EG@135614|Xanthomonadales 135614|Xanthomonadales G 6-phosphogluconate dehydrogenase gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_412140_1 1121405.dsmv_0617 1.83e-115 343.0 COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,42NHH@68525|delta/epsilon subdivisions,2WJ6M@28221|Deltaproteobacteria,2MIS1@213118|Desulfobacterales 28221|Deltaproteobacteria C FAD dependent oxidoreductase qmoA - - ko:K16885 - - - - ko00000 - - - FAD_oxidored,NAD_binding_8,Pyr_redox_2 k59_279928_1 633.DJ40_1690 2.34e-73 231.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,41F6W@629|Yersinia 1236|Gammaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_1032768_2 1205680.CAKO01000002_gene2180 8.32e-50 165.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2TS0J@28211|Alphaproteobacteria,2JPTC@204441|Rhodospirillales 204441|Rhodospirillales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_348478_1 1437882.AZRU01000211_gene2685 5.06e-26 110.0 COG0583@1|root,COG0583@2|Bacteria,1RJXD@1224|Proteobacteria,1SBA9@1236|Gammaproteobacteria,1YFB4@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_771946_1 1049564.TevJSym_bc00370 3.77e-33 120.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_771946_2 870187.Thini_0278 4.86e-74 234.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,4637B@72273|Thiotrichales 72273|Thiotrichales C Fe-S oxidoreductase - - - - - - - - - - - - CCG,Fer4_8 k59_348489_1 1129794.C427_1227 1.62e-32 125.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,465UT@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_15125_2 1410666.JHXG01000003_gene1429 2.36e-20 90.5 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,4NFTI@976|Bacteroidetes,2FNSJ@200643|Bacteroidia 976|Bacteroidetes C CoA binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1001313_1 998674.ATTE01000001_gene2458 2.17e-52 173.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,460P6@72273|Thiotrichales 72273|Thiotrichales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1001313_2 349124.Hhal_2302 4.25e-121 354.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1WWRE@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_248855_1 1304885.AUEY01000072_gene1710 5.01e-28 110.0 COG2605@1|root,COG2605@2|Bacteria,1QW1A@1224|Proteobacteria,42N0X@68525|delta/epsilon subdivisions,2WK4R@28221|Deltaproteobacteria,2MKF9@213118|Desulfobacterales 28221|Deltaproteobacteria S GHMP kinases C terminal - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_248855_2 1304885.AUEY01000010_gene1685 1.97e-90 276.0 COG0451@1|root,COG0451@2|Bacteria,1MVI8@1224|Proteobacteria,42R49@68525|delta/epsilon subdivisions,2WNEZ@28221|Deltaproteobacteria,2MN63@213118|Desulfobacterales 28221|Deltaproteobacteria M NAD(P)H-binding - - 5.1.3.25 ko:K17947 ko00523,ko01130,map00523,map01130 - R10279 RC00289 ko00000,ko00001,ko01000 - - - Epimerase k59_1032769_1 572544.Ilyop_0690 0.0 888.0 COG1894@1|root,COG1894@2|Bacteria,378S3@32066|Fusobacteria 32066|Fusobacteria C PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit hymB - 1.12.1.3 ko:K18331 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_1032769_2 572544.Ilyop_0689 0.0 1004.0 COG1034@1|root,COG4624@1|root,COG1034@2|Bacteria,COG4624@2|Bacteria,378BF@32066|Fusobacteria 32066|Fusobacteria C PFAM hydrogenase large subunit domain protein - - 1.12.1.3,1.6.5.3 ko:K00336,ko:K18332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3 k59_1032769_3 1499683.CCFF01000016_gene789 3.94e-84 264.0 COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,24BDQ@186801|Clostridia,36G47@31979|Clostridiaceae 186801|Clostridia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1032769_4 572544.Ilyop_0738 2.17e-161 462.0 COG2081@1|root,COG2081@2|Bacteria,379W7@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_706698_2 713586.KB900536_gene2283 1.18e-12 66.2 2913D@1|root,2ZNQV@2|Bacteria,1P4TF@1224|Proteobacteria,1SV4Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_837274_1 1158318.ATXC01000001_gene1083 1.49e-41 152.0 COG3303@1|root,COG3303@2|Bacteria,2G4ZH@200783|Aquificae 200783|Aquificae P Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto k59_379916_1 697282.Mettu_1909 1.42e-25 110.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XE97@135618|Methylococcales 135618|Methylococcales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_771954_1 563040.Saut_1875 3.23e-12 62.0 2E7QP@1|root,30HJH@2|Bacteria,1Q381@1224|Proteobacteria,431QW@68525|delta/epsilon subdivisions,2YSC6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_771954_3 880073.Calab_0995 1.18e-27 107.0 COG0501@1|root,COG0501@2|Bacteria,2NS4G@2323|unclassified Bacteria 2|Bacteria O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_85441_1 713587.THITH_00995 1.69e-32 129.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RRGT@1236|Gammaproteobacteria,1X2AB@135613|Chromatiales 135613|Chromatiales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - DUF3365,HATPase_c,HisKA,Response_reg k59_1032777_1 497321.C664_16610 1.97e-82 263.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,2KVEC@206389|Rhodocyclales 206389|Rhodocyclales V COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_444407_1 671143.DAMO_3069 6.77e-100 301.0 COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria 2|Bacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.29,2.3.1.47,2.3.1.50 ko:K00639,ko:K00652,ko:K00654 ko00260,ko00600,ko00780,ko01100,ko04071,ko04138,map00260,map00600,map00780,map01100,map04071,map04138 M00094,M00099,M00123,M00573,M00577 R00371,R01281,R03210,R10124 RC00004,RC00039,RC00394,RC02725,RC02849 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_576269_1 1168034.FH5T_14015 2.51e-91 277.0 COG0389@1|root,COG0389@2|Bacteria,4NF1Y@976|Bacteroidetes,2FNAN@200643|Bacteroidia 976|Bacteroidetes L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_576269_2 1346330.M472_19425 5.38e-48 174.0 COG2885@1|root,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPAI@117747|Sphingobacteriia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - ANAPC3,CarboxypepD_reg,OmpA,PD40 k59_512025_1 1192868.CAIU01000003_gene385 3e-17 86.7 COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2TSS4@28211|Alphaproteobacteria,43IVF@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Belongs to the mandelate racemase muconate lactonizing enzyme family catB - 5.5.1.1 ko:K01856 ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220 M00568 R05300,R05390,R06989,R08116,R09229 RC00903,RC01038,RC01108,RC01321,RC01356 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_738008_1 552811.Dehly_1699 5.44e-161 462.0 2CDJ3@1|root,2Z7R6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_738008_2 644282.Deba_1839 1.84e-86 274.0 28J6X@1|root,2Z92E@2|Bacteria,1R426@1224|Proteobacteria,42NPX@68525|delta/epsilon subdivisions,2WMA7@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_512030_1 748247.AZKH_p0046 3.24e-102 306.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,2KUSU@206389|Rhodocyclales 206389|Rhodocyclales P COG0798 Arsenite efflux pump ACR3 and related permeases arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_217304_1 1121405.dsmv_1510 1.57e-58 200.0 COG3829@1|root,COG3829@2|Bacteria,1N4M6@1224|Proteobacteria,42M38@68525|delta/epsilon subdivisions,2WIR0@28221|Deltaproteobacteria,2MHN7@213118|Desulfobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - GAF_2,HTH_8,PAS_3,PAS_9,Response_reg,Sigma54_activat k59_837296_2 1121472.AQWN01000002_gene2128 1.86e-13 70.1 COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,262CC@186807|Peptococcaceae 186801|Clostridia L TIGRFAM Competence protein ComEA, helix-hairpin-helix comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB k59_837296_3 873449.STRCR_1093 0.000149 48.9 COG1309@1|root,COG1309@2|Bacteria,1V0VT@1239|Firmicutes,4HPD3@91061|Bacilli 91061|Bacilli K Transcriptional regulator - - - - - - - - - - - - TetR_N,WHG k59_379935_1 159087.Daro_4112 6.46e-134 394.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,2KV0S@206389|Rhodocyclales 206389|Rhodocyclales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_379935_2 1121013.P873_13325 4.64e-40 140.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1X6DJ@135614|Xanthomonadales 135614|Xanthomonadales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_379935_3 1288494.EBAPG3_29130 4.24e-06 48.5 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,372ZX@32003|Nitrosomonadales 28216|Betaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_444425_1 176299.Atu4861 7.63e-20 87.4 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,4B7HG@82115|Rhizobiaceae 28211|Alphaproteobacteria L insertion sequence ATP-binding protein y4iQ y4nD y4sD - - - - - - - - - - - - IstB_IS21 k59_444425_2 555793.WSK_1845 3.68e-47 171.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales 204457|Sphingomonadales L Integrase core domain - - - - - - - - - - - - rve k59_22622_2 1069534.LRC_07930 8.23e-77 240.0 COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,4HDZQ@91061|Bacilli,3F5AK@33958|Lactobacillaceae 91061|Bacilli E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_452532_1 1569209.BBPH01000070_gene513 4.42e-17 82.8 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSZ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family alsS - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_616450_1 1168034.FH5T_01495 6.8e-47 160.0 COG1595@1|root,COG2202@1|root,COG1595@2|Bacteria,COG2202@2|Bacteria 2|Bacteria T Pas domain - - - ko:K03088 - - - - ko00000,ko03021 - - - DUF4157,HATPase_c,PAS,PAS_3,PAS_9,SatD,Sigma70_r2 k59_256128_1 1336803.PHEL49_2629 3.79e-142 441.0 COG0457@1|root,COG3206@1|root,COG0457@2|Bacteria,COG3206@2|Bacteria,4NH33@976|Bacteroidetes,1HYMC@117743|Flavobacteriia,3VX4T@52959|Polaribacter 976|Bacteroidetes M ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_287606_1 1049564.TevJSym_bq00040 4.28e-86 260.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1J6E5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfG - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_483757_2 1049564.TevJSym_ah00220 2.41e-33 118.0 COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 k59_483757_3 1198232.CYCME_1173 1.1e-12 64.3 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,460WA@72273|Thiotrichales 72273|Thiotrichales D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_355251_1 331678.Cphamn1_0514 7.56e-74 250.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - HemolysinCabind k59_551638_1 1168034.FH5T_10355 5.33e-108 321.0 COG1168@1|root,COG1168@2|Bacteria,4NETH@976|Bacteroidetes,2FMIZ@200643|Bacteroidia 976|Bacteroidetes E Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_551638_2 742735.HMPREF9467_04167 2.05e-72 227.0 COG2045@1|root,COG2045@2|Bacteria,1V56I@1239|Firmicutes,248U8@186801|Clostridia,22263@1506553|Lachnoclostridium 186801|Clostridia H 2-phosphosulpholactate phosphatase comB - 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp k59_256141_1 1172190.M947_05800 8.93e-49 160.0 2B0BZ@1|root,31SP3@2|Bacteria,1RM1T@1224|Proteobacteria,42RVA@68525|delta/epsilon subdivisions,2YPBI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_682148_1 653733.Selin_1851 1.48e-107 320.0 COG1118@1|root,COG1118@2|Bacteria 2|Bacteria P Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system modC - 3.6.3.25,3.6.3.29 ko:K02017,ko:K02018,ko:K02045 ko00920,ko02010,map00920,map02010 M00185,M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.1,3.A.1.6.3,3.A.1.8 - - ABC_tran,BPD_transp_1 k59_224391_1 765912.Thimo_3687 1.46e-92 279.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales 135613|Chromatiales I PFAM Phospholipid glycerol acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1040517_1 1070774.J07HN4v3_00049 5.78e-52 188.0 COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota,23S2B@183963|Halobacteria 183963|Halobacteria E amino acid - - - - - - - - - - - - AA_permease,AA_permease_2,Usp k59_22636_1 709032.Sulku_0121 2.93e-71 238.0 COG5001@1|root,COG5001@2|Bacteria,1R4H0@1224|Proteobacteria,43CII@68525|delta/epsilon subdivisions,2YTD5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF k59_256146_1 557598.LHK_01210 3.18e-07 52.4 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,2KPNM@206351|Neisseriales 206351|Neisseriales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_256146_2 439235.Dalk_1639 1.22e-27 102.0 COG2331@1|root,COG2331@2|Bacteria,1NA92@1224|Proteobacteria,42VCN@68525|delta/epsilon subdivisions,2WRQP@28221|Deltaproteobacteria,2MKWP@213118|Desulfobacterales 28221|Deltaproteobacteria S regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_616472_1 385682.AFSL01000065_gene1683 1.81e-78 249.0 COG0561@1|root,COG0561@2|Bacteria,4PMJY@976|Bacteroidetes,2G0E4@200643|Bacteroidia 976|Bacteroidetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_583871_1 1005999.GLGR_1039 1.92e-44 152.0 COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,1RRRC@1236|Gammaproteobacteria 1236|Gammaproteobacteria M outer membrane protein W ompW GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K07275 - - - - ko00000 - - - OmpW k59_519752_1 1178825.ALIH01000002_gene874 4.11e-68 235.0 COG1132@1|root,COG2274@1|root,COG1132@2|Bacteria,COG2274@2|Bacteria 2|Bacteria V protein secretion by the type I secretion system lagD - - ko:K02021,ko:K06147,ko:K13409,ko:K18996,ko:K19171 ko02010,ko04626,map02010,map04626 M00339 - - ko00000,ko00001,ko00002,ko02000,ko02044,ko02048,ko03032 3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39,RP-C,RP-C_C,cNMP_binding k59_583873_1 700598.Niako_0744 2.67e-20 96.3 COG3408@1|root,COG3408@2|Bacteria,4NE1I@976|Bacteroidetes,1IRGN@117747|Sphingobacteriia 976|Bacteroidetes G Domain of unknown function (DUF4450) - - - - - - - - - - - - Bac_rhamnosid6H,DUF4450,DUF608 k59_1008243_1 933262.AXAM01000184_gene3441 1.88e-10 62.4 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2MIPM@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM EAL domain - - - - - - - - - - - - CZB,EAL,GGDEF,PAS_3,PAS_9,SnoaL_3,dCache_2 k59_1008243_2 519989.ECTPHS_11020 1.56e-71 229.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales 135613|Chromatiales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_93041_1 1168034.FH5T_18420 1.13e-183 521.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,2FM4G@200643|Bacteroidia 976|Bacteroidetes I Carboxyl transferase domain protein mmdA - - - - - - - - - - - Carboxyl_trans k59_844058_1 367737.Abu_1137 3.56e-19 81.6 COG1396@1|root,COG1396@2|Bacteria,1Q68X@1224|Proteobacteria,432N2@68525|delta/epsilon subdivisions,2YSQF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Helix-turn-helix - - - - - - - - - - - - HTH_19,HTH_3 k59_844058_2 158500.BV97_01915 6.55e-20 103.0 COG1572@1|root,COG2931@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2K0IP@204457|Sphingomonadales 204457|Sphingomonadales Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HCBP_related,He_PIG,HemolysinCabind k59_287638_1 314345.SPV1_11761 2.86e-75 241.0 COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria 1224|Proteobacteria C Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation sthA GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019725,GO:0022857,GO:0022890,GO:0034220,GO:0036094,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902600 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_4669,iECs_1301.ECs4891,iZ_1308.Z5521 Pyr_redox_2,Pyr_redox_dim k59_975020_1 471853.Bcav_1943 5.59e-93 293.0 COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria 201174|Actinobacteria E amino acid ydaO - - - - - - - - - - - AA_permease_2 k59_779235_1 1319815.HMPREF0202_01765 3.14e-79 250.0 COG2326@1|root,COG2326@2|Bacteria,37CBD@32066|Fusobacteria 32066|Fusobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_519768_1 1123401.JHYQ01000013_gene684 1.8e-32 125.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S7A2@1236|Gammaproteobacteria,463JM@72273|Thiotrichales 72273|Thiotrichales D sister chromatid segregation - - - - - - - - - - - - - k59_93044_1 572544.Ilyop_1087 1.16e-134 395.0 COG1220@1|root,COG1220@2|Bacteria,379DK@32066|Fusobacteria 32066|Fusobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_93044_2 572544.Ilyop_1086 2.56e-57 199.0 COG1196@1|root,COG1196@2|Bacteria,37848@32066|Fusobacteria 32066|Fusobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_943272_1 1385935.N836_04685 1.92e-05 51.6 COG3240@1|root,COG3240@2|Bacteria,1G2TV@1117|Cyanobacteria,1HAZN@1150|Oscillatoriales 1117|Cyanobacteria I GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - HemolysinCabind,Lipase_GDSL,VPEP k59_58576_1 312309.VF_1103 1.39e-17 80.1 COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,1S8Y4@1236|Gammaproteobacteria,1XX3I@135623|Vibrionales 135623|Vibrionales O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_943280_1 765912.Thimo_1245 2.96e-48 167.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1WVWG@135613|Chromatiales 135613|Chromatiales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_583915_1 1121405.dsmv_0357 4.18e-74 231.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,2MIIA@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Methylenetetrahydrofolate reductase - - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_160221_1 34506.g1926 1.36e-53 190.0 COG0249@1|root,KOG0217@2759|Eukaryota,38DKA@33154|Opisthokonta,3BBVI@33208|Metazoa,3CV2W@33213|Bilateria,40BXR@6231|Nematoda,1KUA5@119089|Chromadorea,40SGY@6236|Rhabditida 33208|Metazoa L Component of the post-replicative DNA mismatch repair system (MMR) - - - - - - - - - - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_713958_1 1165841.SULAR_09969 3.54e-65 206.0 COG0546@1|root,COG0546@2|Bacteria,1RBMZ@1224|Proteobacteria,42RG3@68525|delta/epsilon subdivisions,2YP44@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hydrolase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_483800_1 1121924.ATWH01000009_gene129 1.34e-30 114.0 COG5646@1|root,COG5646@2|Bacteria,2HN7Z@201174|Actinobacteria,4FPE3@85023|Microbacteriaceae 201174|Actinobacteria S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 k59_519798_1 1565314.OA34_10050 2.67e-48 172.0 COG1538@1|root,COG1538@2|Bacteria,1PZ8W@1224|Proteobacteria,42Q8Z@68525|delta/epsilon subdivisions,2YN8G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_808224_2 1390370.O203_05750 0.000516 45.8 COG4701@1|root,COG4701@2|Bacteria,1NHRC@1224|Proteobacteria,1SDJY@1236|Gammaproteobacteria,1YGCK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 k59_387931_1 1536772.R70723_20195 9.99e-23 93.2 2C4JB@1|root,30BI1@2|Bacteria,1VEBD@1239|Firmicutes,4HM1J@91061|Bacilli,26YBF@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_126115_1 1122604.JONR01000023_gene4196 1.75e-20 95.5 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1X4TX@135614|Xanthomonadales 135614|Xanthomonadales M membrane - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_975034_1 879212.DespoDRAFT_00445 4.32e-31 129.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2MI1W@213118|Desulfobacterales 28221|Deltaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_779255_1 1121017.AUFG01000080_gene928 1.41e-64 204.0 COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4FFJP@85021|Intrasporangiaceae 201174|Actinobacteria L DNA replication protein - - - - - - - - - - - - IstB_IS21 k59_387934_1 929703.KE386491_gene772 2.83e-99 323.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,4NFBV@976|Bacteroidetes,47K85@768503|Cytophagia 976|Bacteroidetes EQ Hydantoinase/oxoprolinase - - 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_649202_1 388413.ALPR1_21088 1.34e-83 285.0 COG1361@1|root,COG3210@1|root,COG5184@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - CHU_C,DUF11 k59_1008279_1 574087.Acear_1202 3.42e-36 132.0 COG1075@1|root,COG1075@2|Bacteria,1VJP5@1239|Firmicutes,250IX@186801|Clostridia,3WBMR@53433|Halanaerobiales 186801|Clostridia S Putative serine esterase (DUF676) - - - - - - - - - - - - DUF676 k59_22707_1 997884.HMPREF1068_00920 2.23e-31 117.0 COG1897@1|root,COG1897@2|Bacteria,4NEUV@976|Bacteroidetes,2FPRH@200643|Bacteroidia,4AM11@815|Bacteroidaceae 976|Bacteroidetes E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metAA GO:0003674,GO:0003824,GO:0008374,GO:0008899,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_22707_2 485917.Phep_1875 2.57e-34 128.0 COG2873@1|root,COG2873@2|Bacteria,4NE27@976|Bacteroidetes,1IPSV@117747|Sphingobacteriia 976|Bacteroidetes E Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_808231_1 1537917.JU82_02515 7.02e-74 231.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,42NAS@68525|delta/epsilon subdivisions,2YN3V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the agmatine deiminase family aguA - - - - - - - - - - - PAD_porph k59_287670_1 1168034.FH5T_13085 2.49e-185 519.0 COG1216@1|root,COG1216@2|Bacteria,4PPEY@976|Bacteroidetes,2G18V@200643|Bacteroidia 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_126122_1 224308.BSU17210 1.07e-20 97.4 COG1020@1|root,COG1028@1|root,COG3321@1|root,COG4221@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HTBC@91061|Bacilli,1ZS7J@1386|Bacillus 91061|Bacilli IQ polyketide synthase - - - ko:K13611,ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_256202_1 572544.Ilyop_0381 2.07e-75 241.0 COG1538@1|root,COG1538@2|Bacteria,37A6H@32066|Fusobacteria 32066|Fusobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_519822_1 933262.AXAM01000044_gene1408 1.12e-94 290.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2MKFC@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_224460_1 870187.Thini_0608 2.59e-63 202.0 COG4221@1|root,COG4221@2|Bacteria,1R9DN@1224|Proteobacteria,1T2NM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Short-chain dehydrogenase reductase Sdr - - - - - - - - - - - - adh_short k59_551739_1 1131814.JAFO01000001_gene1837 5.49e-42 157.0 COG0421@1|root,COG4262@1|root,COG0421@2|Bacteria,COG4262@2|Bacteria,1QVKE@1224|Proteobacteria,2U21Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_616529_2 572477.Alvin_2539 7.82e-55 189.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_160274_1 1168034.FH5T_04170 6.43e-116 366.0 COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,2FMWR@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_452624_1 1168034.FH5T_09800 1.36e-39 133.0 2ASAT@1|root,31HQ0@2|Bacteria,4PEUH@976|Bacteroidetes,2G01X@200643|Bacteroidia 976|Bacteroidetes S Prokaryotic Cytochrome C oxidase subunit IV - - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - COX4_pro k59_452624_2 1168034.FH5T_09805 3.95e-200 557.0 COG1622@1|root,COG1622@2|Bacteria,4NFNF@976|Bacteroidetes,2FX9N@200643|Bacteroidia 976|Bacteroidetes C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM k59_519840_1 713587.THITH_00915 5.79e-47 152.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1WYVV@135613|Chromatiales 135613|Chromatiales J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_519840_2 1234364.AMSF01000001_gene2353 6.94e-36 131.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1X32F@135614|Xanthomonadales 135614|Xanthomonadales H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_126404_1 1123279.ATUS01000001_gene1142 1.38e-15 79.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1J4TE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - ic_1306.c0216 Hexapep,Hexapep_2,LpxD k59_126404_2 768671.ThimaDRAFT_2150 1.52e-11 62.8 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1WY1I@135613|Chromatiales 135613|Chromatiales M PFAM Outer membrane - - - ko:K06142 - - - - ko00000 - - - OmpH k59_780030_1 1168034.FH5T_16455 3.19e-66 221.0 COG0072@1|root,COG0072@2|Bacteria,4NF5B@976|Bacteroidetes,2FNBF@200643|Bacteroidia 976|Bacteroidetes J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_944041_1 1121405.dsmv_2949 2.33e-37 131.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2MJ2V@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_944041_2 177437.HRM2_18680 2.5e-24 102.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2WJAU@28221|Deltaproteobacteria,2MJ5H@213118|Desulfobacterales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07644 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_910485_1 158500.BV97_03066 2.77e-61 211.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2K0EB@204457|Sphingomonadales 204457|Sphingomonadales P P-type ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_617519_3 98439.AJLL01000034_gene2882 1.05e-17 84.7 COG0797@1|root,COG0797@2|Bacteria,1G0XF@1117|Cyanobacteria,1JH60@1189|Stigonemataceae 1117|Cyanobacteria M Lytic transglycolase rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1 k59_126413_1 998674.ATTE01000001_gene1687 7.01e-55 178.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,460JJ@72273|Thiotrichales 72273|Thiotrichales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_126413_2 1122604.JONR01000018_gene1117 1.33e-18 84.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1X31Z@135614|Xanthomonadales 135614|Xanthomonadales S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_388992_1 234267.Acid_5651 4.45e-29 117.0 COG4881@1|root,COG4881@2|Bacteria 2|Bacteria - - cbcU - - - - - - - - - - - NrfD k59_160866_1 324925.Ppha_2000 5.72e-68 216.0 COG0031@1|root,COG0031@2|Bacteria,1FD8M@1090|Chlorobi 1090|Chlorobi H PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_453612_1 768671.ThimaDRAFT_2620 3.33e-19 86.3 COG1075@1|root,COG1075@2|Bacteria,1R5PK@1224|Proteobacteria,1RP0G@1236|Gammaproteobacteria,1WX6E@135613|Chromatiales 135613|Chromatiales S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6 k59_453612_2 1131814.JAFO01000001_gene4455 2.27e-38 144.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3EY3U@335928|Xanthobacteraceae 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K21134 - M00821 - - ko00000,ko00002,ko02000 2.A.6.2.27 - - ACR_tran k59_388994_1 396588.Tgr7_1224 1.15e-47 165.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,1RMRB@1236|Gammaproteobacteria,1WVV3@135613|Chromatiales 135613|Chromatiales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_59306_1 439235.Dalk_4515 1.27e-91 286.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_59306_2 439235.Dalk_5241 1.22e-49 160.0 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,42URZ@68525|delta/epsilon subdivisions,2WQ58@28221|Deltaproteobacteria,2MKGK@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_427133_2 391008.Smal_3536 6.1e-25 97.8 2AMA3@1|root,31C50@2|Bacteria,1RK5D@1224|Proteobacteria,1S717@1236|Gammaproteobacteria,1X8I0@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF2628) - - - - - - - - - - - - DUF2628 k59_721581_1 1168034.FH5T_04680 2.76e-49 159.0 COG2236@1|root,COG2236@2|Bacteria,4NRJB@976|Bacteroidetes,2FS1M@200643|Bacteroidia 976|Bacteroidetes F Phosphoribosyl transferase domain - - - ko:K07101 - - - - ko00000 - - - Pribosyltran k59_721581_2 1168034.FH5T_04620 7.23e-06 48.1 COG1082@1|root,COG1082@2|Bacteria,4NJ3Z@976|Bacteroidetes 976|Bacteroidetes G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 k59_558254_1 1117647.M5M_04620 8.35e-33 124.0 COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D von Willebrand factor (VWF) type A domain - - - - - - - - - - - - VWA_2 k59_558254_2 1415778.JQMM01000001_gene1135 9.81e-14 73.6 COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Secreted protein, containing von Willebrand factor (VWF) type - - - - - - - - - - - - - k59_917917_1 652103.Rpdx1_4703 8.84e-54 184.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,3K09N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC1 family - - - - - - - - - - - - ABC1 k59_67603_1 879212.DespoDRAFT_01421 3.23e-64 206.0 28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_590752_1 404589.Anae109_3067 2.9e-82 265.0 COG1948@1|root,COG4880@2|Bacteria,1PQKR@1224|Proteobacteria,438JJ@68525|delta/epsilon subdivisions,2X3U8@28221|Deltaproteobacteria,2YX4D@29|Myxococcales 28221|Deltaproteobacteria L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_198447_1 1408445.JHXP01000011_gene936 4.47e-83 262.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1JDCB@118969|Legionellales 118969|Legionellales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA rsmB GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_917923_2 1207076.ALAT01000120_gene3558 8.05e-18 82.0 COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,1S6W9@1236|Gammaproteobacteria,1Z2TY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S 4-hydroxybenzoyl-CoA thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2,Acyl-ACP_TE k59_917923_3 929558.SMGD1_2485 6.74e-41 148.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2YN9N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - POR_N,TPP_enzyme_C k59_884708_1 298386.PBPRA1265 8.56e-125 375.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,1XUC7@135623|Vibrionales 135623|Vibrionales Q COG2015 Alkyl sulfatase and related hydrolases - - - ko:K01138 - - - - ko00000,ko01000 - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_1015636_1 472759.Nhal_1290 8.08e-83 275.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales 135613|Chromatiales L TIGRFAM ATP-dependent helicase HrpA - - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_100493_1 768671.ThimaDRAFT_2328 1.34e-100 320.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_492764_1 765913.ThidrDRAFT_0847 5.76e-208 601.0 COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1WWG2@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_166020_1 207559.Dde_1418 1.33e-116 357.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,42MP9@68525|delta/epsilon subdivisions,2WJWN@28221|Deltaproteobacteria,2M98S@213115|Desulfovibrionales 28221|Deltaproteobacteria V PFAM ABC transporter - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_982931_1 929558.SMGD1_1288 5.87e-138 408.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,42MPN@68525|delta/epsilon subdivisions,2YMHV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar basal body protein flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_982931_2 1537917.JU82_03140 7.31e-82 250.0 COG1843@1|root,COG1843@2|Bacteria,1PQS2@1224|Proteobacteria,42TAQ@68525|delta/epsilon subdivisions,2YPFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgD,FlgD_ig k59_166021_1 713587.THITH_17370 0.000212 45.8 COG0575@1|root,COG0575@2|Bacteria 2|Bacteria I Belongs to the CDS family cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41,2.7.7.67 ko:K00981,ko:K19664 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799,R08966 RC00002 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1397 CTP_transf_1,CarS-like k59_754027_1 443143.GM18_2924 3.48e-110 336.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42MUF@68525|delta/epsilon subdivisions,2WK25@28221|Deltaproteobacteria 28221|Deltaproteobacteria V DNA methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_329500_2 572544.Ilyop_1542 5.43e-147 423.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,3786Q@32066|Fusobacteria 32066|Fusobacteria M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_329500_3 910314.HMPREF9220_0130 3.14e-46 156.0 COG1778@1|root,COG1778@2|Bacteria,1V5JJ@1239|Firmicutes,4H4ID@909932|Negativicutes 909932|Negativicutes S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_34735_1 556267.HWAG_00616 2.26e-61 199.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,42M8N@68525|delta/epsilon subdivisions,2YMFN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family hprA - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_67629_1 563040.Saut_1076 4.44e-59 199.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,42N0P@68525|delta/epsilon subdivisions,2YN14@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C UPF0313 protein - - - - - - - - - - - - Radical_SAM,Radical_SAM_N k59_67629_2 1165841.SULAR_03108 6.68e-85 261.0 COG0561@1|root,COG0561@2|Bacteria,1Q5G6@1224|Proteobacteria,42R7D@68525|delta/epsilon subdivisions,2YP2E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S of the HAD superfamily - - - - - - - - - - - - Hydrolase_3 k59_852527_2 381666.H16_A3357 1.19e-57 194.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23,OmpA k59_198472_1 1298920.KI911353_gene4460 1.11e-63 204.0 COG0500@1|root,COG2226@2|Bacteria,1UVHG@1239|Firmicutes,25KIB@186801|Clostridia,221KJ@1506553|Lachnoclostridium 186801|Clostridia Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_394702_1 1249480.B649_11800 9.83e-111 336.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,42P71@68525|delta/epsilon subdivisions,2YNAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Phospholipid glycerol acyltransferase - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_133337_1 1125863.JAFN01000001_gene3523 5.5e-06 47.4 COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,42RAV@68525|delta/epsilon subdivisions,2WNTB@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Pseudouridine synthase truC - 5.4.99.26 ko:K06175 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_2 k59_133337_2 395493.BegalDRAFT_1654 3.81e-47 165.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,460CN@72273|Thiotrichales 72273|Thiotrichales P Acts as a magnesium transporter - - - - - - - - - - - - CBS,MgtE,MgtE_N k59_688927_1 396588.Tgr7_0799 7.61e-93 286.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1WXAG@135613|Chromatiales 135613|Chromatiales E PFAM sodium alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_852529_1 1049564.TevJSym_bs00060 5.75e-86 275.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1J517@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_525558_1 1168034.FH5T_20055 9.14e-110 320.0 COG0313@1|root,COG0313@2|Bacteria,4NDXE@976|Bacteroidetes,2FN1A@200643|Bacteroidia 976|Bacteroidetes H Psort location Cytoplasmic, score 8.96 rsmI_1 - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_198481_1 1168034.FH5T_04590 6.96e-121 367.0 COG1185@1|root,COG1185@2|Bacteria,4NE4Q@976|Bacteroidetes,2FN5H@200643|Bacteroidia 976|Bacteroidetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_852537_1 998674.ATTE01000001_gene356 5.82e-90 270.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,4606Q@72273|Thiotrichales 72273|Thiotrichales L Exodeoxyribonuclease III xth - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_688932_1 1122621.ATZA01000014_gene3243 1.63e-117 352.0 COG0554@1|root,COG0554@2|Bacteria,4NFUH@976|Bacteroidetes,1IP31@117747|Sphingobacteriia 976|Bacteroidetes C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_166045_1 1255043.TVNIR_2335 4.44e-28 105.0 COG1917@1|root,COG1917@2|Bacteria,1N0G1@1224|Proteobacteria,1SDYY@1236|Gammaproteobacteria,1WZKB@135613|Chromatiales 135613|Chromatiales S Cupin domain - - - - - - - - - - - - Cupin_2 k59_166045_2 880073.Calab_3366 1.58e-116 345.0 COG2248@1|root,COG2248@2|Bacteria 2|Bacteria - - VP1164 - - ko:K07022,ko:K07089 - - - - ko00000 - - - ArsP_2 k59_982963_1 1206737.BAGF01000148_gene5908 2.65e-20 92.4 COG0329@1|root,COG0329@2|Bacteria,2IGVB@201174|Actinobacteria,4FUJG@85025|Nocardiaceae 201174|Actinobacteria EM Dihydrodipicolinate synthetase family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_917967_1 1319815.HMPREF0202_02808 7.82e-126 367.0 COG0050@1|root,COG0050@2|Bacteria,3784P@32066|Fusobacteria 32066|Fusobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1015665_1 671143.DAMO_2419 2.55e-47 160.0 COG1573@1|root,COG1573@2|Bacteria,2NP99@2323|unclassified Bacteria 2|Bacteria L Uracil DNA glycosylase superfamily dpo - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_590793_1 929558.SMGD1_1598 4.16e-139 407.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42PIT@68525|delta/epsilon subdivisions,2YTJQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX k59_590793_2 929558.SMGD1_1599 3.31e-49 162.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42PYJ@68525|delta/epsilon subdivisions,2YREA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - ABC_tran k59_754044_1 287.DR97_2485 5.9e-12 68.6 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1YEMU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_754044_3 1319815.HMPREF0202_01622 1.27e-44 149.0 COG4731@1|root,COG4731@2|Bacteria,37AQ5@32066|Fusobacteria 32066|Fusobacteria S Uncharacterized protein conserved in bacteria (DUF2147) - - - - - - - - - - - - DUF2147 k59_460288_2 944547.ABLL_0031 1.47e-105 319.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,42MNG@68525|delta/epsilon subdivisions,2YNM4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation - - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_492801_1 879212.DespoDRAFT_00375 7.93e-135 408.0 COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,42NVV@68525|delta/epsilon subdivisions,2WJIZ@28221|Deltaproteobacteria,2MIHG@213118|Desulfobacterales 28221|Deltaproteobacteria L TIGRFAM exonuclease SbcC sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SbcCD_C k59_623502_2 469617.FUAG_00864 5.92e-100 297.0 COG0357@1|root,COG0357@2|Bacteria,378G5@32066|Fusobacteria 32066|Fusobacteria J Specifically methylates the N7 position of a guanine in 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_623502_3 572544.Ilyop_0605 0.0 979.0 COG0445@1|root,COG0445@2|Bacteria,3790F@32066|Fusobacteria 32066|Fusobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_623502_4 572544.Ilyop_0604 2.19e-88 266.0 COG0569@1|root,COG0569@2|Bacteria,379BC@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score 8.96 - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_623502_5 572544.Ilyop_0603 1.08e-193 551.0 COG0168@1|root,COG0168@2|Bacteria,37893@32066|Fusobacteria 32066|Fusobacteria P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_623502_6 1121324.CLIT_23c01290 7e-23 90.5 2E3FD@1|root,32YE7@2|Bacteria,1VEE4@1239|Firmicutes,24QJ7@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - TSCPD k59_623502_7 1286171.EAL2_c21690 3.64e-46 161.0 COG1656@1|root,COG1656@2|Bacteria,1V62E@1239|Firmicutes,24IZW@186801|Clostridia 186801|Clostridia H Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_623502_8 1033810.HLPCO_001197 6.95e-54 189.0 COG0069@1|root,COG0069@2|Bacteria,2NP08@2323|unclassified Bacteria 2|Bacteria E Glutamate synthase central domain - - 1.4.7.1,2.1.1.21 ko:K00284,ko:K22083 ko00630,ko00680,ko00910,ko01120,map00630,map00680,map00910,map01120 - R00021,R01586,R10086 RC00006,RC00010,RC00554 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase,Rubredoxin k59_688940_2 225117.XP_009366572.1 5.38e-06 47.4 2CV7H@1|root,2RRGK@2759|Eukaryota,383A9@33090|Viridiplantae,3GS0R@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_656511_1 521719.ATXQ01000003_gene2231 1.93e-52 177.0 COG1668@1|root,COG1668@2|Bacteria,1NUA9@1224|Proteobacteria 1224|Proteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_362253_1 1249480.B649_06535 7.94e-299 819.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,42MMI@68525|delta/epsilon subdivisions,2YNPZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase protein alpha chain - - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_1790_1 159087.Daro_1741 5.12e-85 264.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2VI50@28216|Betaproteobacteria,2KU6X@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rmlD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_754049_1 1122919.KB905577_gene3319 9.19e-16 82.0 arCOG08054@1|root,2Z8AD@2|Bacteria,1TQ1J@1239|Firmicutes,4HDNN@91061|Bacilli,26R46@186822|Paenibacillaceae 91061|Bacilli S Dockerin type 1 - - - - - - - - - - - - Cthe_2159 k59_427198_1 469618.FVAG_02562 1.12e-68 210.0 COG0735@1|root,COG0735@2|Bacteria,37ADT@32066|Fusobacteria 32066|Fusobacteria P Belongs to the Fur family - - - ko:K03711,ko:K09825 - - - - ko00000,ko03000 - - - FUR k59_427198_2 391009.Tmel_1201 1.16e-15 73.2 COG2033@1|root,COG2033@2|Bacteria 2|Bacteria C superoxide reductase activity dfx - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrod_N,Desulfoferrodox k59_590801_1 977880.RALTA_A2890 3.87e-83 275.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae 28216|Betaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_166069_2 1121405.dsmv_2408 8.89e-19 83.6 COG0613@1|root,COG0613@2|Bacteria,1RF04@1224|Proteobacteria,42RR4@68525|delta/epsilon subdivisions,2WNC8@28221|Deltaproteobacteria,2MKJW@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP,PHP_C k59_329543_1 1168034.FH5T_17205 3.87e-193 553.0 COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NKE3@976|Bacteroidetes,2FNTG@200643|Bacteroidia 976|Bacteroidetes M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA k59_263700_1 566466.NOR53_841 1.14e-63 211.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1J7Q9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_786953_1 1232437.KL662061_gene4187 8.86e-49 171.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Pyr_redox_2 k59_688954_1 767817.Desgi_0931 1.25e-63 213.0 COG0471@1|root,COG0471@2|Bacteria,1TSP2@1239|Firmicutes,24DU3@186801|Clostridia,26769@186807|Peptococcaceae 186801|Clostridia P Similarity to COG0471 Di- and tricarboxylate transporters(Evalue - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_786959_1 857087.Metme_3359 1.11e-45 167.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1XG1J@135618|Methylococcales 135618|Methylococcales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_623516_1 632245.CLP_0320 3.13e-66 213.0 COG0371@1|root,COG0371@2|Bacteria,1TQFU@1239|Firmicutes,248KH@186801|Clostridia,36ED1@31979|Clostridiaceae 186801|Clostridia C Dehydrogenase - - 1.1.1.6 ko:K00005 ko00561,ko00640,ko01100,map00561,map00640,map01100 - R01034,R10715,R10717 RC00029,RC00117,RC00670 ko00000,ko00001,ko01000 - - - Fe-ADH k59_623516_2 572544.Ilyop_1622 4.13e-18 85.5 COG1388@1|root,COG1388@2|Bacteria 2|Bacteria M LysM domain - - 3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45 ko:K01119,ko:K02040,ko:K07261,ko:K08307,ko:K11751,ko:K19223 ko00230,ko00240,ko00760,ko01100,ko01110,ko02010,ko02020,ko05152,map00230,map00240,map00760,map01100,map01110,map02010,map02020,map05152 M00222 R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135 RC00017,RC00078,RC00296 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02000 3.A.1.7 CBM50 - 5_nucleotid_C,DUF928,Glyco_hydro_25,LysM,Metallophos,PBP_like_2 k59_721667_2 1283300.ATXB01000002_gene2887 3.31e-47 162.0 COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome C family protein - - - - - - - - - - - - Cytochrome_C554,Paired_CXXCH_1 k59_590808_1 1355374.JARU01000006_gene1726 6.45e-141 426.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YM9E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL,Patched k59_67675_1 243233.MCA2870 2.67e-44 159.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XDNC@135618|Methylococcales 135618|Methylococcales EH synthase component I pabB - 2.6.1.85 ko:K01665 ko00790,map00790 - R01716 RC00010,RC01418 ko00000,ko00001,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_624007_2 1212548.B381_15278 1.87e-61 208.0 COG0819@1|root,COG1022@1|root,COG0819@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1YZPG@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria I Long-chain acyl-CoA - - - - - - - - - - - - AMP-binding,Haem_oxygenas_2 k59_133979_1 768671.ThimaDRAFT_4706 2.8e-53 180.0 COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WX18@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_624014_1 1313172.YM304_36330 0.0002 49.7 COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria 201174|Actinobacteria G hydrolase, family 3 bglK - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 k59_330102_1 1121271.AUCM01000002_gene4147 5.41e-22 94.4 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM Nad-dependent epimerase dehydratase - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_330102_3 1318628.MARLIPOL_06709 4.22e-16 75.5 COG4122@1|root,COG4122@2|Bacteria,1QXFR@1224|Proteobacteria,1T3AR@1236|Gammaproteobacteria,466XS@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_918612_1 765911.Thivi_0478 6.14e-21 92.8 COG3039@1|root,COG3039@2|Bacteria,1N88K@1224|Proteobacteria 1224|Proteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_3 k59_35289_1 309803.CTN_1933 9.17e-12 71.6 COG4796@1|root,COG4796@2|Bacteria,2GDBK@200918|Thermotogae 200918|Thermotogae U Belongs to the GSP D family - - - - - - - - - - - - STN,Secretin k59_35289_2 319224.Sputcn32_0559 0.000943 43.1 2DR7A@1|root,33AIK@2|Bacteria,1NGEC@1224|Proteobacteria,1SGK6@1236|Gammaproteobacteria,2QCST@267890|Shewanellaceae 1236|Gammaproteobacteria - - mshK - - ko:K12281 - - - - ko00000,ko02044 - - - - k59_924253_3 526218.Sterm_2206 4.69e-57 186.0 COG2860@1|root,COG2860@2|Bacteria,37AJ3@32066|Fusobacteria 32066|Fusobacteria S UPF0126 domain - - - - - - - - - - - - UPF0126 k59_924253_4 469618.FVAG_00276 1.04e-11 62.8 COG1739@1|root,COG1739@2|Bacteria,379VT@32066|Fusobacteria 32066|Fusobacteria S Uncharacterized protein family UPF0029 - - - - - - - - - - - - UPF0029 k59_629862_1 1565314.OA34_09005 1.37e-68 224.0 COG0671@1|root,COG2453@1|root,COG0671@2|Bacteria,COG2453@2|Bacteria,1QSUD@1224|Proteobacteria,42TZH@68525|delta/epsilon subdivisions,2YPTC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IT Dual specificity phosphatase, catalytic domain - - - - - - - - - - - - DSPc,PAP2_3 k59_532122_1 443152.MDG893_12363 9.46e-23 98.2 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,4659R@72275|Alteromonadaceae 1236|Gammaproteobacteria M Lytic murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_662820_1 396588.Tgr7_1428 5.4e-28 107.0 2EC4Z@1|root,3363S@2|Bacteria,1N9YG@1224|Proteobacteria,1SSSK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_400322_1 935557.ATYB01000014_gene1401 6.05e-16 88.6 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BIY6@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc,TPR_19,TPR_8 k59_532128_1 709032.Sulku_2151 4.27e-112 329.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2YMK7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_172298_1 1121405.dsmv_0664 1.63e-58 195.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJUN@28221|Deltaproteobacteria,2MIK6@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_237244_2 293826.Amet_3695 1.88e-45 153.0 COG0716@1|root,COG0716@2|Bacteria,1VBEZ@1239|Firmicutes,24JJ6@186801|Clostridia,36K16@31979|Clostridiaceae 186801|Clostridia C Flavodoxin - - - - - - - - - - - - Flavodoxin_4,Flavodoxin_5 k59_237244_3 350688.Clos_2737 1.02e-21 90.5 COG0346@1|root,COG0346@2|Bacteria,1VD8Q@1239|Firmicutes,24JY7@186801|Clostridia,36K1K@31979|Clostridiaceae 186801|Clostridia E Glyoxalase bleomycin resistance protein dioxygenase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_825604_1 1391647.AVSV01000002_gene1257 1.37e-27 112.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE k59_107187_1 1408473.JHXO01000001_gene2490 1.65e-16 78.2 COG0477@1|root,COG2814@2|Bacteria,4NG5F@976|Bacteroidetes,2FPA7@200643|Bacteroidia 976|Bacteroidetes EGP Psort location CytoplasmicMembrane, score 10.00 ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - BT1,MFS_1 k59_107187_2 1408473.JHXO01000004_gene4 7.01e-67 207.0 COG0454@1|root,COG0456@2|Bacteria,4NY4B@976|Bacteroidetes,2FVZ2@200643|Bacteroidia 976|Bacteroidetes K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_336179_1 1249480.B649_05760 9.79e-64 218.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YM96@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cmeF - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_662826_1 1168034.FH5T_10410 5.44e-124 391.0 COG0841@1|root,COG1131@1|root,COG0841@2|Bacteria,COG1131@2|Bacteria,4NF8M@976|Bacteroidetes,2FQY7@200643|Bacteroidia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ABC_tran,ACR_tran k59_662826_2 742817.HMPREF9449_02773 3.91e-08 54.7 COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes,2FM1V@200643|Bacteroidia,22WWN@171551|Porphyromonadaceae 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_857821_1 1026882.MAMP_01831 4.35e-218 624.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,1RQD4@1236|Gammaproteobacteria,4605W@72273|Thiotrichales 72273|Thiotrichales I Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_857821_2 572477.Alvin_0818 1.76e-60 196.0 COG0642@1|root,COG0642@2|Bacteria,1QVPJ@1224|Proteobacteria,1T2G0@1236|Gammaproteobacteria,1WWWD@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - HATPase_c k59_857821_3 765910.MARPU_09810 9.64e-131 398.0 COG0457@1|root,COG0784@1|root,COG0457@2|Bacteria,COG0784@2|Bacteria,1NNCT@1224|Proteobacteria,1RY9B@1236|Gammaproteobacteria,1WXKE@135613|Chromatiales 135613|Chromatiales T PFAM response regulator receiver - - - - - - - - - - - - Response_reg,TPR_16,TPR_19,TPR_8 k59_857821_5 498211.CJA_2421 3.06e-115 348.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1FG97@10|Cellvibrio 1236|Gammaproteobacteria C FAD dependent oxidoreductase eryB - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO k59_857821_6 1168065.DOK_16483 4.64e-36 135.0 COG0584@1|root,COG0584@2|Bacteria,1QJ6D@1224|Proteobacteria,1TH3Y@1236|Gammaproteobacteria,1J6E4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Glycerophosphoryl diester phosphodiesterase family - - - - - - - - - - - - GDPD k59_857821_7 1045854.WKK_02540 1.07e-54 197.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,4H9ZF@91061|Bacilli 91061|Bacilli F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_857821_8 555779.Dthio_PD0651 4.36e-157 491.0 COG3857@1|root,COG3857@2|Bacteria 2|Bacteria L exonuclease activity addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - Exonuc_V_gamma,PDDEXK_1,UvrD_C k59_857821_9 228410.NE2166 1.42e-311 905.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VHNB@28216|Betaproteobacteria,371VU@32003|Nitrosomonadales 28216|Betaproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_857821_10 1163617.SCD_n02324 5.81e-110 328.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria 28216|Betaproteobacteria J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_857821_11 1249627.D779_0434 3.45e-75 228.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1WXYW@135613|Chromatiales 135613|Chromatiales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_857821_12 1049564.TevJSym_ab00620 5.46e-162 466.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1J5BC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II IV02_28760 - - - - - - - - - - - Aminotran_1_2 k59_857821_13 589873.EP13_06825 5.1e-41 140.0 2DMZS@1|root,32UN9@2|Bacteria,1P0ZP@1224|Proteobacteria,1SRYC@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_857821_14 1469245.JFBG01000076_gene148 1.78e-63 206.0 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1WWYG@135613|Chromatiales 135613|Chromatiales E High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ - - ko:K06203 - - - - ko00000 - - - DnaJ,EI24 k59_857821_15 1049564.TevJSym_ac01780 1.93e-105 313.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1J4IP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_857821_16 211165.AJLN01000145_gene1245 1.26e-25 107.0 COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1JH83@1189|Stigonemataceae 1117|Cyanobacteria H 4'-phosphopantetheinyl transferase superfamily hetI GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_857821_17 1134474.O59_002218 1.71e-223 638.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1FGUD@10|Cellvibrio 1236|Gammaproteobacteria L DHH family recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_857821_18 1118153.MOY_11892 1.84e-28 110.0 COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria,1XK14@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the UPF0307 family - - - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_857821_19 713586.KB900536_gene370 1.7e-25 100.0 COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,1SEBT@1236|Gammaproteobacteria,1WZ6I@135613|Chromatiales 135613|Chromatiales C TIGRFAM Succinate dehydrogenase, cytochrome b556 subunit - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_857821_20 1049564.TevJSym_bc00450 2.02e-30 111.0 COG2142@1|root,COG2142@2|Bacteria 2|Bacteria C succinate dehydrogenase activity sdhD GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017004,GO:0017144,GO:0019752,GO:0020037,GO:0022607,GO:0022900,GO:0032991,GO:0034622,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0065003,GO:0070469,GO:0070470,GO:0071704,GO:0071840,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - e_coli_core.b0722,iAF1260.b0722,iAPECO1_1312.APECO1_1356,iB21_1397.B21_00671,iBWG_1329.BWG_0581,iE2348C_1286.E2348C_0602,iEC042_1314.EC042_0740,iECABU_c1320.ECABU_c07680,iECBD_1354.ECBD_2938,iECB_1328.ECB_00682,iECDH10B_1368.ECDH10B_0789,iECDH1ME8569_1439.ECDH1ME8569_0681,iECD_1391.ECD_00682,iECED1_1282.ECED1_0692,iECIAI1_1343.ECIAI1_0696,iECIAI39_1322.ECIAI39_0680,iECNA114_1301.ECNA114_0658,iECO103_1326.ECO103_0716,iECO111_1330.ECO111_0739,iECO26_1355.ECO26_0783,iECOK1_1307.ECOK1_0722,iECP_1309.ECP_0734,iECS88_1305.ECS88_0748,iECSE_1348.ECSE_0782,iECSF_1327.ECSF_0655,iECUMN_1333.ECUMN_0800,iECW_1372.ECW_m0777,iEKO11_1354.EKO11_3157,iETEC_1333.ETEC_0733,iEcDH1_1363.EcDH1_2913,iEcE24377_1341.EcE24377A_0749,iEcHS_1320.EcHS_A0770,iEcSMS35_1347.EcSMS35_0735,iEcolC_1368.EcolC_2933,iJO1366.b0722,iJR904.b0722,iLF82_1304.LF82_2100,iNRG857_1313.NRG857_03215,iSBO_1134.SBO_0580,iSDY_1059.SDY_0660,iSFV_1184.SFV_0613,iSF_1195.SF0575,iSFxv_1172.SFxv_0634,iSSON_1240.SSON_0673,iS_1188.S0588,iUMN146_1321.UM146_14010,iUMNK88_1353.UMNK88_758,iUTI89_1310.UTI89_C0718,iWFL_1372.ECW_m0777,iY75_1357.Y75_RS03755,ic_1306.c0800 Sdh_cyt k59_857821_21 396588.Tgr7_1467 0.0 878.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales 135613|Chromatiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_857821_22 768671.ThimaDRAFT_0172 1.04e-133 382.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1WWKQ@135613|Chromatiales 135613|Chromatiales C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 k59_857821_23 314287.GB2207_04477 1.73e-10 59.3 COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria,1J7BM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Flavinator of succinate dehydrogenase ygfY GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564 - ko:K09159 - - - - ko00000,ko02048 - - - Sdh5 k59_857821_25 572477.Alvin_1727 1.78e-282 784.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_857821_26 765912.Thimo_1822 1.06e-91 273.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1WXBZ@135613|Chromatiales 135613|Chromatiales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_857821_27 472759.Nhal_0714 1.66e-17 84.3 COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SGPC@1236|Gammaproteobacteria,1WYNC@135613|Chromatiales 135613|Chromatiales T PFAM Anti sigma-E protein RseA - - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N k59_663615_1 387093.SUN_1088 5.65e-128 380.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42N76@68525|delta/epsilon subdivisions,2YN3W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ AMP-dependent synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_990079_1 1168034.FH5T_00840 1.43e-69 229.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,2FNQB@200643|Bacteroidia 976|Bacteroidetes G pectate lyase K01728 - - - - - - - - - - - - Pec_lyase_C k59_532943_2 498211.CJA_0343 3.24e-05 49.3 COG1520@1|root,COG3209@1|root,COG1520@2|Bacteria,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - Calx-beta,DUF1566,DUF4114,DUF4347,FG-GAP,HemolysinCabind,PQQ_3,RHS,RHS_repeat,SLH k59_630402_1 345219.Bcoa_0878 6.57e-20 98.2 COG2327@1|root,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,4IM2M@91061|Bacilli,1ZIX0@1386|Bacillus 91061|Bacilli S Polysaccharide pyruvyl transferase - - - ko:K16710 - - - - ko00000 - - - PS_pyruv_trans k59_630402_2 1123393.KB891333_gene2608 1.55e-135 399.0 COG0673@1|root,COG0673@2|Bacteria,1PF0E@1224|Proteobacteria,2W9B2@28216|Betaproteobacteria,1KTHN@119069|Hydrogenophilales 119069|Hydrogenophilales S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_630402_3 1502770.JQMG01000001_gene2220 1.54e-101 313.0 COG0027@1|root,COG0027@2|Bacteria,1R7DD@1224|Proteobacteria 1224|Proteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate - - - - - - - - - - - - ATP-grasp_4,CPSase_L_D2,Dala_Dala_lig_C k59_630402_4 1123517.JOMR01000001_gene1331 8.03e-148 426.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RQ7S@1236|Gammaproteobacteria,460D1@72273|Thiotrichales 72273|Thiotrichales E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_925100_1 760154.Sulba_0147 3.41e-10 59.7 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2YMMF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Abc transporter znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_925100_2 1322246.BN4_11402 3.47e-77 241.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,42NI8@68525|delta/epsilon subdivisions,2WKMZ@28221|Deltaproteobacteria,2MA5G@213115|Desulfovibrionales 28221|Deltaproteobacteria P pfam abc - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_597766_1 1255043.TVNIR_2870 1.52e-26 108.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1WXT0@135613|Chromatiales 135613|Chromatiales S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_727789_1 1127673.GLIP_3684 0.000437 42.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,46490@72275|Alteromonadaceae 1236|Gammaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - iJN746.PP_0104 COX1 k59_727789_2 301.JNHE01000020_gene3994 2.43e-50 171.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1YDWB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_40648_1 525898.Sdel_1108 4.16e-37 139.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2YMKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_205594_1 572544.Ilyop_1849 4.87e-15 75.9 COG0206@1|root,COG0206@2|Bacteria,378TM@32066|Fusobacteria 32066|Fusobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_205594_2 1319815.HMPREF0202_01508 1.8e-34 120.0 COG0360@1|root,COG0360@2|Bacteria,37APH@32066|Fusobacteria 32066|Fusobacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_205594_3 572544.Ilyop_0859 1.63e-66 205.0 COG0629@1|root,COG0629@2|Bacteria,37A98@32066|Fusobacteria 32066|Fusobacteria L Single-stranded DNA-binding protein ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_205594_4 523794.Lebu_0212 4.75e-25 95.5 COG0238@1|root,COG0238@2|Bacteria,37AM4@32066|Fusobacteria 32066|Fusobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_990094_1 754477.Q7C_1547 2.27e-61 199.0 COG0551@1|root,COG0551@2|Bacteria,1PZFI@1224|Proteobacteria,1RQ64@1236|Gammaproteobacteria,460HW@72273|Thiotrichales 72273|Thiotrichales L Topoisomerase DNA binding C4 zinc finger - - - - - - - - - - - - NERD,zf-C4_Topoisom k59_727791_1 1046627.BZARG_393 7.92e-14 68.9 COG4929@1|root,COG4929@2|Bacteria,4NRFH@976|Bacteroidetes,1I3D3@117743|Flavobacteriia 976|Bacteroidetes S GDYXXLXY protein - - - - - - - - - - - - GDYXXLXY k59_727791_2 1101195.Meth11DRAFT_2209 6.77e-83 263.0 2AT3Q@1|root,31IJS@2|Bacteria,1RIYP@1224|Proteobacteria,2W2W1@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4401) - - - - - - - - - - - - DUF4401 k59_990095_2 519989.ECTPHS_05440 4.58e-43 150.0 COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,1RSDK@1236|Gammaproteobacteria,1WVUU@135613|Chromatiales 135613|Chromatiales O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_826401_1 545264.KB898755_gene2822 0.000232 44.3 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,1WZFI@135613|Chromatiales 135613|Chromatiales U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_826401_2 1150399.AQYK01000001_gene1465 6.6e-71 221.0 COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria,4FNZB@85023|Microbacteriaceae 201174|Actinobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_500253_1 709032.Sulku_0206 3.71e-50 162.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2YPXD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_500253_2 1537917.JU82_09505 1.48e-73 224.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,42NSE@68525|delta/epsilon subdivisions,2YMUG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_727800_1 870187.Thini_4272 1.88e-93 286.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,45ZY8@72273|Thiotrichales 72273|Thiotrichales C Belongs to the aldehyde dehydrogenase family - - 1.2.1.32,1.2.1.85 ko:K10217 ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00362,map00380,map00622,map01100,map01120,map01220 M00038,M00569 R02762,R03889,R05353 RC00218,RC00254 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_956675_1 1168034.FH5T_18730 1.32e-84 276.0 COG0653@1|root,COG0653@2|Bacteria,4NF7C@976|Bacteroidetes,2FMVF@200643|Bacteroidia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_826406_1 675814.VIC_004374 1.67e-124 365.0 COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,1RMKA@1236|Gammaproteobacteria,1XSCU@135623|Vibrionales 135623|Vibrionales S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_826406_2 386415.NT01CX_0289 1.06e-61 202.0 COG1105@1|root,COG1105@2|Bacteria,1TR9H@1239|Firmicutes,25CD6@186801|Clostridia,36WTQ@31979|Clostridiaceae 186801|Clostridia H Belongs to the carbohydrate kinase PfkB family. LacC subfamily lacC - 2.7.1.144,2.7.1.56 ko:K00882,ko:K00917 ko00051,ko00052,ko01100,map00051,map00052,map01100 - R02071,R03236 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_597796_2 269797.Mbar_A0770 3.98e-38 132.0 COG0716@1|root,arCOG00519@2157|Archaea,2XXH8@28890|Euryarchaeota,2NADI@224756|Methanomicrobia 224756|Methanomicrobia C Flavodoxin - - - - - - - - - - - - Flavodoxin_4 k59_500264_1 1121396.KB893058_gene2546 3.59e-67 206.0 arCOG05017@1|root,3015V@2|Bacteria,1RDNC@1224|Proteobacteria,42RJ5@68525|delta/epsilon subdivisions,2WNJP@28221|Deltaproteobacteria,2MJGW@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF3343) - - - - - - - - - - - - DUF3343 k59_500264_2 879212.DespoDRAFT_03557 3.95e-51 169.0 COG0063@1|root,COG0063@2|Bacteria,1R3U6@1224|Proteobacteria,42NVK@68525|delta/epsilon subdivisions,2WJZE@28221|Deltaproteobacteria,2MIH2@213118|Desulfobacterales 28221|Deltaproteobacteria G Carbohydrate kinase - - - - - - - - - - - - Carb_kinase k59_663658_1 749222.Nitsa_0477 1.68e-110 334.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2YMQ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H acetolactate synthase ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_727809_2 1123326.JFBL01000001_gene1327 3.66e-40 135.0 2BR28@1|root,32K00@2|Bacteria,1Q2JJ@1224|Proteobacteria,42VUT@68525|delta/epsilon subdivisions,2YQF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S NifQ - - - ko:K15790 - - - - ko00000 - - - NifQ k59_727809_3 944547.ABLL_0038 1.16e-10 61.6 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2YMHJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_891452_1 398580.Dshi_0889 2.05e-122 358.0 COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria 28211|Alphaproteobacteria E amino acid aldolase or racemase dhaa - 4.1.3.41 ko:K18425 - - - - ko00000,ko01000 - - - Ala_racemase_N,D-ser_dehydrat k59_826409_1 743299.Acife_2059 0.000174 41.6 2E3TC@1|root,32YQV@2|Bacteria,1N7A9@1224|Proteobacteria,1SC92@1236|Gammaproteobacteria 1236|Gammaproteobacteria S copG family - - - - - - - - - - - - CopG_antitoxin k59_826409_2 1166130.H650_02280 1.02e-27 105.0 2EGCV@1|root,33A4N@2|Bacteria,1NZ2N@1224|Proteobacteria,1SQP2@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_826409_3 1205683.CAKR01000046_gene1108 2.17e-17 78.2 2EG4B@1|root,339WA@2|Bacteria,1PB2F@1224|Proteobacteria,1STB7@1236|Gammaproteobacteria,41HIG@629|Yersinia 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_695536_1 1121481.AUAS01000003_gene4042 5.8e-06 46.2 COG0713@1|root,COG0713@2|Bacteria,4NTBP@976|Bacteroidetes,47QG0@768503|Cytophagia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_695536_2 653733.Selin_0882 1.88e-40 141.0 COG0839@1|root,COG0839@2|Bacteria 2|Bacteria C Belongs to the complex I subunit 6 family nuoJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_695536_3 1565314.OA34_01985 3.73e-37 130.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42T2H@68525|delta/epsilon subdivisions,2YPIS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_7 k59_40674_1 1168034.FH5T_07275 1.77e-124 360.0 28H74@1|root,2Z7JF@2|Bacteria,4NFR0@976|Bacteroidetes,2FQ0B@200643|Bacteroidia 976|Bacteroidetes S Gliding motility-associated protein GldN gldN - - - - - - - - - - - - k59_931879_1 469617.FUAG_01677 1.27e-145 424.0 COG0520@1|root,COG0520@2|Bacteria,379NA@32066|Fusobacteria 32066|Fusobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_46921_1 335543.Sfum_0758 1.03e-28 119.0 COG4775@1|root,COG4775@2|Bacteria,1QX52@1224|Proteobacteria,43CEZ@68525|delta/epsilon subdivisions,2X7PY@28221|Deltaproteobacteria,2MRBQ@213462|Syntrophobacterales 28221|Deltaproteobacteria M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_767831_1 572544.Ilyop_0926 6.35e-60 191.0 COG1659@1|root,COG1659@2|Bacteria,379CM@32066|Fusobacteria 32066|Fusobacteria S Encapsulating protein for peroxidase - - - - - - - - - - - - Linocin_M18 k59_767831_2 572544.Ilyop_0925 8.04e-38 130.0 COG3461@1|root,COG3461@2|Bacteria,37AZD@32066|Fusobacteria 32066|Fusobacteria S Evidence 4 Homologs of previously reported genes of - - - ko:K09700 - - - - ko00000 - - - - k59_213074_1 749222.Nitsa_0776 7.65e-85 280.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,43BJD@68525|delta/epsilon subdivisions,2YNEB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I 2-acylglycerophosphoethanolamine acyltransferase aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_637759_1 1283300.ATXB01000001_gene1723 3.5e-56 190.0 COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - Glutaredoxin k59_408051_1 1049564.TevJSym_bc00390 8.8e-154 447.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Nickel-dependent hydrogenase hydB - 1.12.5.1,1.12.99.6 ko:K05922,ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_540152_1 215803.DB30_7204 1.34e-98 310.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,42YZ6@68525|delta/epsilon subdivisions,2WU2X@28221|Deltaproteobacteria,2YXQD@29|Myxococcales 28221|Deltaproteobacteria E FAD dependent oxidoreductase central domain - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_670800_1 565045.NOR51B_2687 2.05e-58 192.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1J4VV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D recombinase XerD xerD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_997268_2 1537917.JU82_01070 7.77e-56 182.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2YN8Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_309503_1 563040.Saut_0672 1.19e-23 100.0 COG0810@1|root,COG0810@2|Bacteria,1R7A2@1224|Proteobacteria,42V42@68525|delta/epsilon subdivisions,2YQIP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_473272_1 1168034.FH5T_02690 9.17e-71 224.0 COG0809@1|root,COG0809@2|Bacteria,4NDZ5@976|Bacteroidetes,2FNJD@200643|Bacteroidia 976|Bacteroidetes H Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_473272_2 1235803.C825_03659 2.09e-18 83.6 COG0488@1|root,COG0488@2|Bacteria,4NEHU@976|Bacteroidetes,2FMW7@200643|Bacteroidia,22VV9@171551|Porphyromonadaceae 976|Bacteroidetes S ABC transporter, ATP-binding protein - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_408071_1 1492922.GY26_06000 2.91e-50 181.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J57P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_637775_1 1537917.JU82_03995 5.05e-39 136.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2YMN0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_637775_2 709032.Sulku_0362 2.97e-124 367.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2YMY6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_734116_1 366602.Caul_0182 3.9e-21 90.5 COG3491@1|root,COG3491@2|Bacteria,1MUNT@1224|Proteobacteria,2TU3Y@28211|Alphaproteobacteria,2KFIE@204458|Caulobacterales 204458|Caulobacterales C Belongs to the iron ascorbate-dependent oxidoreductase family - - - - - - - - - - - - 2OG-FeII_Oxy,DIOX_N k59_734116_2 1282876.BAOK01000001_gene2504 1.87e-11 66.2 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,2TU8A@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Nucleoside transporter MA20_32460 - - ko:K03317 - - - - ko00000 2.A.41 - - Nucleos_tra2_C,Nucleos_tra2_N k59_670814_1 1165841.SULAR_09009 7.08e-151 435.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,42MJ1@68525|delta/epsilon subdivisions,2YMZ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0212 M20_dimer,Peptidase_M20 k59_244720_2 1163398.AJJP01000156_gene2807 5.98e-11 59.7 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9EV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 k59_964060_1 1168034.FH5T_14460 9.67e-161 461.0 COG0015@1|root,COG0015@2|Bacteria,4NFY8@976|Bacteroidetes,2FMYF@200643|Bacteroidia 976|Bacteroidetes F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,ASL_C,Lyase_1 k59_670825_1 444158.MmarC6_1489 4.32e-43 147.0 COG0456@1|root,arCOG00833@2157|Archaea,2XYEG@28890|Euryarchaeota,23R5N@183939|Methanococci 183939|Methanococci K PFAM GCN5-related N-acetyltransferase - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_997296_2 1121405.dsmv_3383 8.56e-38 130.0 2EAFJ@1|root,334IY@2|Bacteria,1NA2Y@1224|Proteobacteria,42VJ1@68525|delta/epsilon subdivisions,2WRKE@28221|Deltaproteobacteria,2MKY4@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF1844) - - - - - - - - - - - - DUF1844 k59_473295_1 1454004.AW11_02355 1.44e-108 325.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2VHKV@28216|Betaproteobacteria,1KQSG@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_244735_1 595460.RRSWK_06373 1.07e-39 147.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_865479_1 697281.Mahau_0256 3.74e-101 312.0 COG1158@1|root,COG1158@2|Bacteria,1TPHZ@1239|Firmicutes,247YK@186801|Clostridia,42EXD@68295|Thermoanaerobacterales 186801|Clostridia K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_408109_1 519989.ECTPHS_10636 1.21e-42 144.0 COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,1RP3P@1236|Gammaproteobacteria,1WYJV@135613|Chromatiales 135613|Chromatiales M pfam nlp p60 - - - ko:K13695 - - - - ko00000,ko01002 - - - NLPC_P60 k59_408109_2 765911.Thivi_3071 3.99e-57 199.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1WX2T@135613|Chromatiales 135613|Chromatiales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_670847_1 1165841.SULAR_00710 5.13e-123 388.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2YMRQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_148169_1 525898.Sdel_1790 3.51e-121 354.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,42KZY@68525|delta/epsilon subdivisions,2YMQF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_898713_1 1121929.KB898669_gene3217 1e-06 57.4 COG1657@1|root,COG4223@1|root,COG4412@1|root,COG4677@1|root,COG4733@1|root,COG5297@1|root,COG1657@2|Bacteria,COG4223@2|Bacteria,COG4412@2|Bacteria,COG4677@2|Bacteria,COG4733@2|Bacteria,COG5297@2|Bacteria,1UWTS@1239|Firmicutes,4I2GN@91061|Bacilli,471DJ@74385|Gracilibacillus 91061|Bacilli GI Pectic acid lyase - - - - - - - - - - - - Pec_lyase k59_605340_2 1123277.KB893172_gene976 1.09e-05 50.8 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,47JJJ@768503|Cytophagia 976|Bacteroidetes P TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_833309_1 1304885.AUEY01000080_gene1033 4.55e-107 320.0 COG2801@1|root,COG2801@2|Bacteria,1PFYJ@1224|Proteobacteria,439VW@68525|delta/epsilon subdivisions,2X5A0@28221|Deltaproteobacteria,2MP3D@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - - k59_244754_1 1121405.dsmv_2229 8.28e-12 72.4 COG1520@1|root,COG3391@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria,1PIDG@1224|Proteobacteria,42UM6@68525|delta/epsilon subdivisions,2WPZY@28221|Deltaproteobacteria,2MNQH@213118|Desulfobacterales 28221|Deltaproteobacteria S PQQ-like domain - - - - - - - - - - - - PQQ_3 k59_572157_1 326427.Cagg_3274 6.62e-06 45.4 COG1553@1|root,COG1553@2|Bacteria 2|Bacteria P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE ychN GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0034214,GO:0042802,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051259,GO:0065003,GO:0071840 - ko:K06039 - - - - ko00000 - - - DrsE k59_572157_2 293826.Amet_3279 1.02e-23 99.0 COG0500@1|root,COG2226@2|Bacteria,1V0C5@1239|Firmicutes,24IDC@186801|Clostridia,36P3J@31979|Clostridiaceae 186801|Clostridia Q PFAM UbiE COQ5 methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_375832_1 1121904.ARBP01000010_gene2446 1.08e-33 130.0 COG0729@1|root,COG0729@2|Bacteria,4NEHH@976|Bacteroidetes 976|Bacteroidetes M Surface antigen - - - - - - - - - - - - Bac_surface_Ag k59_180711_1 97139.C824_06082 5.75e-16 76.6 COG1011@1|root,COG1011@2|Bacteria,1TWM7@1239|Firmicutes,24HKY@186801|Clostridia,36FHA@31979|Clostridiaceae 186801|Clostridia S IA, variant 1 - - 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_180711_2 1319815.HMPREF0202_02730 1.66e-07 57.8 COG1396@1|root,COG1396@2|Bacteria,3791H@32066|Fusobacteria 32066|Fusobacteria K sequence-specific DNA binding - - - - - - - - - - - - - k59_964075_1 331678.Cphamn1_1158 2.12e-73 231.0 COG1403@1|root,COG1479@1|root,COG1403@2|Bacteria,COG1479@2|Bacteria 2|Bacteria U Protein of unknown function DUF262 - - - - - - - - - - - - DUF262,HNH k59_605385_1 1238182.C882_1059 2.19e-71 231.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2JPV0@204441|Rhodospirillales 204441|Rhodospirillales S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_833328_1 1279017.AQYJ01000022_gene2613 2.62e-53 186.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,46674@72275|Alteromonadaceae 1236|Gammaproteobacteria S PEGA domain - - - - - - - - - - - - FGE-sulfatase,PEGA k59_10989_1 1122951.ATUE01000006_gene1475 0.000412 43.1 COG5654@1|root,COG5654@2|Bacteria,1N6P3@1224|Proteobacteria,1S7EU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S RES domain protein - - - - - - - - - - - - RES k59_244775_1 1537917.JU82_04920 3.12e-41 149.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_244775_2 709032.Sulku_1575 4.38e-190 533.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2YN8F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family frdB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0191 Fer2_3,Fer4_8 k59_244775_3 1249480.B649_07295 6.28e-27 105.0 COG2048@1|root,COG2048@2|Bacteria,1RFWK@1224|Proteobacteria,43B86@68525|delta/epsilon subdivisions,2YT6P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Heterodisulfide reductase subunit B - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - CCG k59_309556_1 1123368.AUIS01000019_gene1205 7.83e-116 342.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_473343_2 765911.Thivi_1842 8.46e-97 296.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P k59_46993_1 498211.CJA_3371 2.85e-26 113.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1FFTU@10|Cellvibrio 1236|Gammaproteobacteria M POTRA domain TamA domain 1 - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_148195_1 290512.Paes_2207 1.75e-29 123.0 COG1785@1|root,COG3391@1|root,COG1785@2|Bacteria,COG3391@2|Bacteria,1FDAF@1090|Chlorobi 1090|Chlorobi P Belongs to the alkaline phosphatase family - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase,SWM_repeat k59_473358_1 1168034.FH5T_08420 5.55e-116 348.0 COG0793@1|root,COG0793@2|Bacteria,4NEGV@976|Bacteroidetes,2FP0Y@200643|Bacteroidia 976|Bacteroidetes M Belongs to the peptidase S41A family ctp - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_441396_1 33898.JRHJ01000094_gene3168 1.31e-111 340.0 COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria 201174|Actinobacteria C succinate dehydrogenase sdhA - 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00278 ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00115,M00149,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_474377_1 1168034.FH5T_18330 7.74e-74 243.0 COG0457@1|root,COG0457@2|Bacteria,4P3PK@976|Bacteroidetes 976|Bacteroidetes S Tetratricopeptide repeats - - - - - - - - - - - - - k59_735310_3 1565314.OA34_11955 1.13e-27 103.0 COG2033@1|root,COG2033@2|Bacteria,1NDWH@1224|Proteobacteria,42RSM@68525|delta/epsilon subdivisions,2YP5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Desulfoferrodoxin ferrous iron-binding - - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrodox k59_798175_1 1172190.M947_03470 1.09e-20 88.2 COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VD0@68525|delta/epsilon subdivisions,2YQ93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_798175_2 387093.SUN_0452 5.28e-19 85.9 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2YM87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_277117_1 326298.Suden_1902 6.24e-191 550.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2YMS1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhF - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_474394_1 1540257.JQMW01000013_gene1186 6.25e-64 209.0 COG0025@1|root,COG0025@2|Bacteria,1UHUI@1239|Firmicutes,25E2Y@186801|Clostridia,36UH5@31979|Clostridiaceae 186801|Clostridia P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_245895_1 926692.AZYG01000085_gene856 2.08e-40 147.0 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales 186801|Clostridia L Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_866553_1 717231.Flexsi_1518 7.75e-101 320.0 COG1048@1|root,COG1048@2|Bacteria,2GEP9@200930|Deferribacteres 200930|Deferribacteres C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_541272_1 1101195.Meth11DRAFT_1813 8.85e-24 105.0 COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,2KNF2@206350|Nitrosomonadales 206350|Nitrosomonadales Q TIGRFAM outer membrane adhesin like proteiin - - - - - - - - - - - - Calx-beta,HemolysinCabind k59_672030_1 1123355.JHYO01000042_gene1552 3.39e-91 284.0 COG0639@1|root,COG0639@2|Bacteria,1R8Z8@1224|Proteobacteria,2U3MM@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_672030_2 1528106.JRJE01000032_gene2638 1.06e-18 80.5 2EK96@1|root,33DZF@2|Bacteria,1NI37@1224|Proteobacteria,2UMGV@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_672030_3 319224.Sputcn32_0673 1.35e-54 174.0 COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,1S2DE@1236|Gammaproteobacteria,2QB2K@267890|Shewanellaceae 1236|Gammaproteobacteria S Uncharacterized protein family, UPF0114 yqhA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - UPF0114 k59_998412_1 1168034.FH5T_07765 1.87e-77 246.0 COG1470@1|root,COG1470@2|Bacteria,4NQ03@976|Bacteroidetes,2G2PI@200643|Bacteroidia 976|Bacteroidetes S CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2 k59_606431_1 1123267.JONN01000001_gene1238 5.14e-78 259.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP k59_866574_1 1537994.JQFW01000057_gene360 3.55e-138 412.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,4659B@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_157844_2 765910.MARPU_07605 8.74e-53 179.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1WVYW@135613|Chromatiales 135613|Chromatiales S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_806390_1 443143.GM18_4037 3.59e-19 91.7 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales 28221|Deltaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_285245_1 1168034.FH5T_09330 1.84e-156 459.0 COG0557@1|root,COG0557@2|Bacteria,4NE7T@976|Bacteroidetes,2FMM6@200643|Bacteroidia 976|Bacteroidetes J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573,ko:K12585 ko03018,map03018 M00391 - - ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_157854_1 1165841.SULAR_02893 3.61e-94 284.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2YMY3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O hydrogenase expression formation protein hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_56099_1 1121405.dsmv_2722 2.25e-60 201.0 COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJ17@28221|Deltaproteobacteria,2MJ5Y@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the glutamate synthase family - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4,Fer4_16,Glu_synthase k59_581679_1 177437.HRM2_11750 2.25e-40 148.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S7S@68525|delta/epsilon subdivisions,2WNFR@28221|Deltaproteobacteria,2MJU7@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GAF_2,GGDEF,PAS,PAS_3,PAS_4 k59_842280_1 96561.Dole_2817 5.5e-106 314.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2MIJR@213118|Desulfobacterales 28221|Deltaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N k59_743131_1 1487953.JMKF01000074_gene3681 1.92e-47 174.0 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG3829@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - - - - - - - - - - CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_254100_1 1049564.TevJSym_az00130 9.08e-56 187.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1J5AS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_807052_1 1168034.FH5T_07485 1.82e-84 256.0 COG3622@1|root,COG3622@2|Bacteria,4NG74@976|Bacteroidetes 976|Bacteroidetes G PFAM Xylose isomerase-like TIM barrel - - 5.3.1.22 ko:K01816 ko00630,ko01100,map00630,map01100 - R01394 RC00511 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_941937_1 1408473.JHXO01000005_gene1800 5.52e-21 95.5 COG0657@1|root,COG0657@2|Bacteria,4PKDQ@976|Bacteroidetes,2FNBH@200643|Bacteroidia 976|Bacteroidetes I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 k59_158792_1 1249627.D779_1191 6.45e-19 85.1 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,1WXFQ@135613|Chromatiales 135613|Chromatiales G PFAM Glucose Sorbosone dehydrogenase - - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH k59_158792_2 1122603.ATVI01000005_gene3042 9.43e-23 100.0 COG0668@1|root,COG0668@2|Bacteria,1N4UN@1224|Proteobacteria,1T9TX@1236|Gammaproteobacteria,1XBUR@135614|Xanthomonadales 135614|Xanthomonadales M Conserved TM helix - - - - - - - - - - - - MS_channel,TM_helix k59_482554_2 1168034.FH5T_19365 1.49e-82 256.0 COG2108@1|root,COG2108@2|Bacteria 2|Bacteria S radical SAM - - - ko:K07129 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM k59_777830_1 1168034.FH5T_12915 8.36e-149 428.0 COG0201@1|root,COG0201@2|Bacteria,4NEPU@976|Bacteroidetes,2FPIT@200643|Bacteroidia 976|Bacteroidetes U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_223022_1 1151292.QEW_2571 2.82e-100 301.0 COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,25QHE@186804|Peptostreptococcaceae 186801|Clostridia H Probable molybdopterin binding domain moeA2 - - - - - - - - - - - MoCF_biosynth k59_743834_1 314285.KT71_06252 4.73e-31 125.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S876@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_286186_1 529507.PMI2588 0.000281 51.2 COG3505@1|root,COG3505@2|Bacteria,1MVGD@1224|Proteobacteria,1RNGF@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Conjugal transfer protein TraG traD - - ko:K12071 - - - - ko00000,ko02044 3.A.7.11.1 - - DUF87,TraG-D_C,TrwB_AAD_bind k59_417639_1 1463920.JOGB01000031_gene6062 1.35e-54 192.0 COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria 201174|Actinobacteria M peptidase - - - - - - - - - - - - Peptidase_M23 k59_550031_1 1265505.ATUG01000002_gene2696 5.01e-23 89.4 COG1532@1|root,COG1532@2|Bacteria,1NDUP@1224|Proteobacteria,42WDU@68525|delta/epsilon subdivisions,2WSBV@28221|Deltaproteobacteria,2MKXS@213118|Desulfobacterales 28221|Deltaproteobacteria S Predicted RNA-binding protein - - - - - - - - - - - - RNA_bind_2 k59_550031_2 1304885.AUEY01000055_gene199 1.64e-84 267.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,42MJK@68525|delta/epsilon subdivisions,2WJ8V@28221|Deltaproteobacteria,2MI49@213118|Desulfobacterales 28221|Deltaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,UbiA k59_777841_1 1249480.B649_04270 2.14e-81 251.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2YN2K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iIT341.HP0867 LpxB k59_319022_1 1095747.HMPREF1049_0777 2.77e-79 244.0 COG1209@1|root,COG1209@2|Bacteria,3790C@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_319022_2 469618.FVAG_00376 8.54e-73 230.0 COG1088@1|root,COG1088@2|Bacteria,378J0@32066|Fusobacteria 32066|Fusobacteria M Psort location Cytoplasmic, score rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_680914_1 1502770.JQMG01000001_gene1909 1.56e-09 62.0 COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,2KNSP@206350|Nitrosomonadales 206350|Nitrosomonadales K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_56931_1 1049564.TevJSym_at00740 9.36e-27 103.0 COG0622@1|root,COG0622@2|Bacteria,1RCUQ@1224|Proteobacteria,1S2YE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_56931_2 1245471.PCA10_00740 2.86e-78 240.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1YEDQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_417649_1 1121403.AUCV01000053_gene2648 5.61e-34 124.0 29XYS@1|root,30JRE@2|Bacteria,1RFMZ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_21320_1 211165.AJLN01000116_gene3005 1.48e-25 107.0 COG3016@1|root,COG3016@2|Bacteria,1G1JQ@1117|Cyanobacteria,1JHFW@1189|Stigonemataceae 1117|Cyanobacteria S Haem-binding uptake, Tiki superfamily, ChaN - - - - - - - - - - - - Cofac_haem_bdg k59_482567_1 1121403.AUCV01000022_gene3527 5.05e-46 172.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MHZ1@213118|Desulfobacterales 28221|Deltaproteobacteria S Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - MMPL k59_973882_1 1157708.KB907453_gene4154 1.19e-50 176.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VJ0J@28216|Betaproteobacteria,4AD4F@80864|Comamonadaceae 28216|Betaproteobacteria E Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_518513_1 387093.SUN_1468 1.1e-56 192.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,42YVP@68525|delta/epsilon subdivisions,2YRC0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Conserved region in glutamate synthase - - - - - - - - - - - - Glu_synthase k59_190724_1 1120946.AUBF01000003_gene803 1.17e-19 93.2 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4D4TU@85005|Actinomycetales 201174|Actinobacteria C Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component kgd GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1248c 2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_286212_1 1172190.M947_03990 1.73e-170 483.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,42MKD@68525|delta/epsilon subdivisions,2YMRD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_417665_1 318161.Sden_3533 1.25e-68 228.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,2QBS1@267890|Shewanellaceae 1236|Gammaproteobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_254830_2 1123256.KB907925_gene1205 1.39e-52 174.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1X4H8@135614|Xanthomonadales 135614|Xanthomonadales NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_941951_2 252305.OB2597_02052 1.23e-35 127.0 COG5321@1|root,COG5321@2|Bacteria,1RDXW@1224|Proteobacteria,2U73Y@28211|Alphaproteobacteria,2PE30@252301|Oceanicola 28211|Alphaproteobacteria S DNA repair protein MmcB-like MA20_23405 - - - - - - - - - - - MmcB-like k59_354100_1 768066.HELO_3209 1.05e-46 172.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1XJEF@135619|Oceanospirillales 135619|Oceanospirillales S ErfK YbiS YcfS YnhG family protein - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_908392_1 46429.BV95_01551 1.95e-52 177.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,2K67G@204457|Sphingomonadales 204457|Sphingomonadales L MULE transposase domain - - - - - - - - - - - - Transposase_mut k59_451071_1 196367.JNFG01000209_gene256 1.02e-36 140.0 COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - DUF4277 k59_319042_1 987059.RBXJA2T_12017 2.69e-33 130.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VMJZ@28216|Betaproteobacteria 28216|Betaproteobacteria Q TIGRFAM acyltransferase, WS DGAT MGAT - - - - - - - - - - - - DUF1298,WES_acyltransf k59_319042_2 983917.RGE_07310 1.56e-33 124.0 COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2VPNT@28216|Betaproteobacteria,1KNTZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,PGAP1 k59_582616_1 563040.Saut_0928 2.66e-50 178.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YR2T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG1033 exporter of the RND superfamily protein - - - ko:K07003 - - - - ko00000 - - - MMPL k59_91987_1 765911.Thivi_1628 0.000144 43.1 2AHT8@1|root,3185S@2|Bacteria,1RH98@1224|Proteobacteria,1S7UG@1236|Gammaproteobacteria,1WY6X@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_91987_2 1108045.GORHZ_217_00220 1.12e-59 202.0 COG1226@1|root,COG1226@2|Bacteria 2|Bacteria P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) kch - - - - - - - - - - - Ion_trans_2,TrkA_N k59_743863_1 563040.Saut_0774 1.16e-223 625.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2YMSF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iIT341.HP1134 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_56959_1 936155.HFELIS_16070 2.18e-10 58.2 2AICC@1|root,318TJ@2|Bacteria,1Q0XM@1224|Proteobacteria,431XH@68525|delta/epsilon subdivisions,2YSDI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_680952_1 1537917.JU82_08375 9.46e-109 326.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2YMVE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G phosphomannomutase glmM_1 - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_223060_1 1307761.L21SP2_0400 5.98e-91 280.0 COG0482@1|root,COG0482@2|Bacteria,2J6BI@203691|Spirochaetes 203691|Spirochaetes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_680953_1 1121396.KB893013_gene3702 4.82e-27 109.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,42MX3@68525|delta/epsilon subdivisions,2WKI4@28221|Deltaproteobacteria,2MI7Y@213118|Desulfobacterales 28221|Deltaproteobacteria M Transglycosylase SLT domain - - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_124748_1 1319815.HMPREF0202_02585 9.3e-20 93.6 COG5527@1|root,COG5527@2|Bacteria,379GD@32066|Fusobacteria 32066|Fusobacteria L Initiator RepB protein - - - - - - - - - - - - Rep_3 k59_223061_1 1537917.JU82_03715 1.75e-81 253.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2YMF2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,UPF0004 k59_223061_2 981327.F925_02896 9.09e-05 45.8 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,1RNCW@1236|Gammaproteobacteria,3NJQ8@468|Moraxellaceae 1236|Gammaproteobacteria S HI0933-like protein yhiN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07007 - - - - ko00000 - - - HI0933_like k59_56966_1 387093.SUN_1821 1.34e-41 149.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2YMCF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_158842_1 1173029.JH980292_gene889 3.03e-05 54.3 COG0642@1|root,COG5001@1|root,COG2205@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H871@1150|Oscillatoriales 1117|Cyanobacteria T Cache domain - - - - - - - - - - - - EAL,GAF_2,GAF_3,GGDEF,HAMP,PAS_3,PAS_9,dCache_1 k59_680959_1 1242969.ATCC51562_1071 2e-09 60.1 COG4148@1|root,COG4148@2|Bacteria,1QZCM@1224|Proteobacteria,43CHR@68525|delta/epsilon subdivisions,2YTCI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TOBE domain - - - ko:K02019 - - - - ko00000,ko03000 - - - TOBE k59_1007040_1 1348114.OM33_13380 6.09e-20 81.3 COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria,2Q3IZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Iron-sulphur cluster assembly iscX GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - - - - - - - - - - Fe-S_assembly k59_1007040_2 1158146.KB907122_gene434 7.94e-40 138.0 COG5615@1|root,COG5615@2|Bacteria,1RH6D@1224|Proteobacteria,1S6S2@1236|Gammaproteobacteria,1WZE3@135613|Chromatiales 135613|Chromatiales S Copper resistance protein D - - - - - - - - - - - - CopD k59_417692_1 358681.BBR47_39850 2.7e-101 333.0 COG0236@1|root,COG1020@1|root,COG2227@1|root,COG2230@1|root,COG3321@1|root,COG0236@2|Bacteria,COG1020@2|Bacteria,COG2227@2|Bacteria,COG2230@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae 91061|Bacilli Q Non-ribosomal peptide synthetase modules and related proteins - - - ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_451084_1 43989.cce_3457 1.38e-21 96.7 29WFE@1|root,30I19@2|Bacteria,1GQ76@1117|Cyanobacteria,3KIWC@43988|Cyanothece 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_582627_1 1121912.AUHD01000007_gene489 4.96e-62 212.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family bgaA - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_417697_1 640081.Dsui_1451 1.96e-26 105.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria,2KUV6@206389|Rhodocyclales 206389|Rhodocyclales T (FHA) domain - - - - - - - - - - - - FHA k59_417697_2 1121937.AUHJ01000001_gene696 2.66e-22 95.9 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,464PJ@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_743877_1 987059.RBXJA2T_05493 7.88e-47 162.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,1KK53@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_550056_2 338969.Rfer_3416 7.29e-15 76.6 COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2VQPA@28216|Betaproteobacteria 28216|Betaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_615182_1 1009370.ALO_04983 2.62e-16 81.3 COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,4H1US@909932|Negativicutes 909932|Negativicutes ET Belongs to the bacterial solute-binding protein 3 family glnH - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_941963_1 1265503.KB905165_gene1108 2.06e-10 61.2 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,2Q675@267889|Colwelliaceae 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfE GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0031224,GO:0044425,GO:0044464,GO:0055114,GO:0071944 - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_941963_2 713587.THITH_04365 1.11e-56 187.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1WVYN@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_941963_3 1268239.PALB_4200 3.08e-93 286.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,2PZS8@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944 - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_648045_1 1232410.KI421415_gene3092 2.99e-37 140.0 COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria,43SUB@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_973918_1 768671.ThimaDRAFT_0764 6.17e-85 253.0 COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria,1WWQZ@135613|Chromatiales 135613|Chromatiales C PFAM NADH Ubiquinone - - - - - - - - - - - - Oxidored_q6 k59_254866_1 589865.DaAHT2_1416 5.89e-06 50.4 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit hoxF - 1.6.5.3 ko:K00124,ko:K05587 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 - R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_254866_2 768671.ThimaDRAFT_0763 2.92e-67 210.0 COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria 1224|Proteobacteria C NADH ubiquinone oxidoreductase hoxU - 1.12.1.2 ko:K18006 - - - - ko00000,ko01000 - - - Fer2_4,Fer4_15,NADH-G_4Fe-4S_3 k59_973919_1 380358.XALC_1056 2.66e-64 223.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1X3AB@135614|Xanthomonadales 135614|Xanthomonadales Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_712666_1 933262.AXAM01000009_gene1477 1.97e-64 209.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2MIPA@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM NAD-dependent glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_124773_1 411902.CLOBOL_01977 6.38e-47 162.0 COG1414@1|root,COG1414@2|Bacteria,1V7RD@1239|Firmicutes,24FJ3@186801|Clostridia,21XPG@1506553|Lachnoclostridium 186801|Clostridia K IclR helix-turn-helix domain - - - - - - - - - - - - HTH_IclR,IclR k59_92026_1 563040.Saut_0117 7.92e-66 218.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2YN3Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_286284_1 1046724.KB889930_gene1295 2.77e-31 115.0 COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,1RP20@1236|Gammaproteobacteria,469G1@72275|Alteromonadaceae 1236|Gammaproteobacteria S Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - - - - - - - - - - DUF2235,PilZ k59_254877_1 570952.ATVH01000015_gene1279 2.83e-15 80.1 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,2U85S@28211|Alphaproteobacteria,2JTFP@204441|Rhodospirillales 204441|Rhodospirillales T Universal stress protein family - - - - - - - - - - - - Usp k59_458466_1 351160.RCIX1427 5.91e-08 54.3 COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,2N9XS@224756|Methanomicrobia 224756|Methanomicrobia T Universal stress protein family - - - - - - - - - - - - Usp k59_458466_2 472759.Nhal_2687 2.54e-73 226.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales 135613|Chromatiales V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_458466_3 1500893.JQNB01000001_gene753 6.12e-08 58.5 COG3725@1|root,COG3725@2|Bacteria,1MYFA@1224|Proteobacteria,1SE2J@1236|Gammaproteobacteria,1X4YH@135614|Xanthomonadales 135614|Xanthomonadales V Membrane protein required for beta-lactamase induction ampE - - ko:K03807 - - - - ko00000 - - - CobD_Cbib k59_294990_1 1165841.SULAR_03138 3.41e-69 224.0 COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria,43CEV@68525|delta/epsilon subdivisions,2YRH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_294990_2 1150621.SMUL_3063 4.23e-17 81.3 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2YN15@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Glycosyl hydrolase family 3 - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Amidase_2,Glyco_hydro_3 k59_589264_1 1384054.N790_02845 7.42e-42 156.0 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1X35F@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec k59_817968_1 387093.SUN_0591 4.28e-105 316.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2YMRT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_131485_2 944481.JAFP01000001_gene1338 4.89e-29 112.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42QX2@68525|delta/epsilon subdivisions,2X2Q9@28221|Deltaproteobacteria,2M7MD@213113|Desulfurellales 28221|Deltaproteobacteria HP ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_294992_1 639282.DEFDS_1907 2.87e-69 234.0 COG0841@1|root,COG0841@2|Bacteria,2GESU@200930|Deferribacteres 200930|Deferribacteres V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_360452_1 1121405.dsmv_0516 7.37e-41 150.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,2MJDI@213118|Desulfobacterales 28221|Deltaproteobacteria M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N k59_916085_1 525897.Dbac_0704 9.36e-203 569.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2M8ZB@213115|Desulfovibrionales 28221|Deltaproteobacteria H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_916085_2 96561.Dole_2135 5.64e-213 598.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2MJBU@213118|Desulfobacterales 28221|Deltaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_916085_3 926560.KE387027_gene705 9.11e-21 87.8 COG2044@1|root,COG2044@2|Bacteria 2|Bacteria - - - - - ko:K06039,ko:K07092 - - - - ko00000 - - - DrsE k59_916085_5 187272.Mlg_1507 2e-59 185.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1WYPB@135613|Chromatiales 135613|Chromatiales FG PFAM Histidine triad (HIT) protein - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_916085_6 519989.ECTPHS_10306 9.44e-91 270.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1WY1A@135613|Chromatiales 135613|Chromatiales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_916085_7 555778.Hneap_0770 3.82e-38 130.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1WYVE@135613|Chromatiales 135613|Chromatiales S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_916085_8 1049564.TevJSym_ab01500 6.55e-209 598.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1J4KC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5 k59_916085_9 290512.Paes_0109 1.08e-107 319.0 2F0B4@1|root,33TEC@2|Bacteria,1FEWG@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - k59_608_1 1162668.LFE_2212 5.36e-107 323.0 COG1609@1|root,COG1609@2|Bacteria 2|Bacteria K purine nucleotide biosynthetic process - - 5.3.1.12 ko:K01812,ko:K02529,ko:K16210 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000,ko02000,ko03000 2.A.2.5 - - DDE_Tnp_ISAZ013,Peripla_BP_3 k59_654647_1 32057.KB217478_gene4861 1.46e-15 73.2 COG1605@1|root,COG1605@2|Bacteria,1G8B8@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Chorismate mutase, type II - - 4.2.99.21 ko:K04782 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R06602 RC01549,RC02148 ko00000,ko00001,ko01000 - - - CM_2 k59_654649_1 1121033.AUCF01000036_gene3953 1.26e-48 171.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,2JZH4@204441|Rhodospirillales 204441|Rhodospirillales CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_785274_1 1191523.MROS_1020 5.22e-30 113.0 arCOG07533@1|root,2ZF5I@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4386) - - - - - - - - - - - - DUF4386 k59_785274_2 944547.ABLL_1696 1.42e-72 227.0 COG0454@1|root,COG1305@1|root,COG0456@2|Bacteria,COG1305@2|Bacteria,1RJJ1@1224|Proteobacteria,43B4M@68525|delta/epsilon subdivisions,2YP25@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Acetyltransf_10,Transglut_core k59_611_1 1449069.JMLO01000015_gene621 1.03e-94 294.0 COG0507@1|root,COG3410@1|root,COG0507@2|Bacteria,COG3410@2|Bacteria,2HNSJ@201174|Actinobacteria,4FWM8@85025|Nocardiaceae 201174|Actinobacteria L Uncharacterized conserved protein (DUF2075) - - - ko:K09384 - - - - ko00000 - - - DUF2075 k59_883446_1 3847.GLYMA13G11980.1 7.33e-65 222.0 2CUMQ@1|root,2RN4M@2759|Eukaryota,37U2D@33090|Viridiplantae,3GX5D@35493|Streptophyta,4JTXP@91835|fabids 35493|Streptophyta - - - - - - - - - - - - - - - k59_164323_1 1049564.TevJSym_bh00210 8.34e-28 116.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1J4C5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_8 k59_131497_1 717606.PaecuDRAFT_2938 1.54e-11 70.9 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,4HI3Z@91061|Bacilli,26T2X@186822|Paenibacillaceae 91061|Bacilli T COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg k59_850734_1 1049564.TevJSym_ak00680 4.35e-45 159.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1530 Ribonucleases G and E rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_850734_2 287.DR97_1657 3.84e-23 94.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1YEU5@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria D Maf-like protein yhdE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf k59_491046_1 194867.ALBQ01000020_gene2867 3.16e-08 58.2 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,2K12C@204457|Sphingomonadales 204457|Sphingomonadales H receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_621924_1 177437.HRM2_10980 3.1e-56 190.0 COG5000@1|root,COG5000@2|Bacteria,1QWMS@1224|Proteobacteria,43BSR@68525|delta/epsilon subdivisions,2X73I@28221|Deltaproteobacteria,2MPJM@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_1014157_1 243233.MCA0565 2.86e-35 139.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1XE41@135618|Methylococcales 135618|Methylococcales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_589281_1 105559.Nwat_1431 7.81e-94 303.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_425697_1 1343739.PAP_06030 1.64e-77 249.0 COG4690@1|root,arCOG03602@2157|Archaea,2Y1V5@28890|Euryarchaeota,2438M@183968|Thermococci 183968|Thermococci E Peptidase family C69 - - - - - - - - - - - - Peptidase_C69 k59_131502_1 497321.C664_10817 1.07e-134 400.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,2KUXQ@206389|Rhodocyclales 206389|Rhodocyclales IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_327794_2 572544.Ilyop_0775 2.36e-165 469.0 COG1041@1|root,COG1041@2|Bacteria,37BNT@32066|Fusobacteria 32066|Fusobacteria L Putative RNA methylase family UPF0020 - - - - - - - - - - - - UPF0020 k59_327794_4 1124780.ANNU01000067_gene431 6.89e-55 192.0 COG1575@1|root,COG2249@1|root,COG1575@2|Bacteria,COG2249@2|Bacteria,4NM3V@976|Bacteroidetes,47PKG@768503|Cytophagia 976|Bacteroidetes H NADPH-dependent FMN reductase - - - - - - - - - - - - Flavodoxin_2,UbiA k59_981418_1 526218.Sterm_1607 5.19e-33 125.0 COG0502@1|root,COG0502@2|Bacteria,3785Y@32066|Fusobacteria 32066|Fusobacteria C Biotin and Thiamin Synthesis associated domain hydG - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM k59_981418_3 313606.M23134_06259 1.82e-17 83.6 COG1027@1|root,COG1027@2|Bacteria,4P1PR@976|Bacteroidetes,47M4Z@768503|Cytophagia 976|Bacteroidetes E Fumarase C C-terminus aspA - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 k59_523873_1 1168034.FH5T_17700 1.53e-119 358.0 COG0793@1|root,COG0793@2|Bacteria,4NEGV@976|Bacteroidetes,2FN98@200643|Bacteroidia 976|Bacteroidetes M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_687315_1 187272.Mlg_0267 3.17e-41 144.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1WWC4@135613|Chromatiales 135613|Chromatiales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_98902_1 553178.CAPGI0001_1652 3.27e-06 47.0 COG0102@1|root,COG0102@2|Bacteria,4NNGA@976|Bacteroidetes,1I170@117743|Flavobacteriia,1ERJD@1016|Capnocytophaga 976|Bacteroidetes J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_98902_2 1168034.FH5T_04990 3.51e-118 348.0 COG2177@1|root,COG2177@2|Bacteria,4NH05@976|Bacteroidetes,2FM17@200643|Bacteroidia 976|Bacteroidetes D Belongs to the ABC-4 integral membrane protein family. FtsX subfamily ftsX GO:0005575,GO:0005618,GO:0005623,GO:0006928,GO:0008150,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0043207,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0071944,GO:0071976 - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_295019_1 1144310.PMI07_000140 1.89e-17 83.6 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,4B9ES@82115|Rhizobiaceae 28211|Alphaproteobacteria E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_295019_2 367737.Abu_1443 1.59e-08 55.5 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2YNXT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M (Lipo)protein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_393155_2 215803.DB30_7917 3.44e-76 244.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,42MVI@68525|delta/epsilon subdivisions,2WPP7@28221|Deltaproteobacteria,2YTYB@29|Myxococcales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_393155_3 483216.BACEGG_02759 1.85e-117 365.0 COG1165@1|root,COG1165@2|Bacteria,4NETZ@976|Bacteroidetes,2FMSK@200643|Bacteroidia,4AK78@815|Bacteroidaceae 976|Bacteroidetes H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_818002_1 1444711.CCJF01000005_gene1637 7.71e-65 209.0 COG0266@1|root,COG0266@2|Bacteria,2JGQH@204428|Chlamydiae 204428|Chlamydiae L Formamidopyrimidine-DNA glycosylase H2TH domain - - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_556568_1 1216362.B437_04490 1.06e-18 87.4 COG0161@1|root,COG0161@2|Bacteria,3791N@32066|Fusobacteria 32066|Fusobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_229704_1 469616.FMAG_01466 3.61e-255 710.0 COG0138@1|root,COG0138@2|Bacteria,378DA@32066|Fusobacteria 32066|Fusobacteria F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_229704_2 526218.Sterm_2111 2.77e-86 259.0 COG0299@1|root,COG0299@2|Bacteria,379YW@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_229704_3 526218.Sterm_2110 4.59e-46 158.0 COG0150@1|root,COG0150@2|Bacteria,378FU@32066|Fusobacteria 32066|Fusobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_360489_1 1123008.KB905705_gene932 1.75e-134 395.0 COG0686@1|root,COG0686@2|Bacteria,4NE8F@976|Bacteroidetes,2FP71@200643|Bacteroidia,231XQ@171551|Porphyromonadaceae 976|Bacteroidetes C Alanine dehydrogenase/PNT, N-terminal domain ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_328454_1 572480.Arnit_2316 1.45e-31 126.0 COG0842@1|root,COG0842@2|Bacteria,1R94U@1224|Proteobacteria,42RNF@68525|delta/epsilon subdivisions,2YPAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_328456_1 1411123.JQNH01000001_gene3278 2.14e-84 259.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family phbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_328456_2 1231185.BAMP01000008_gene2145 3.55e-20 87.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,43GSR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria IQ Acetoacetyl-CoA reductase phbB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_66680_1 929558.SMGD1_1320 2.6e-40 142.0 COG1108@1|root,COG1108@2|Bacteria,1Q1MX@1224|Proteobacteria,42U0F@68525|delta/epsilon subdivisions,2YRI4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U ABC 3 transport family - - - ko:K02075 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ABC-3 k59_66680_2 1537917.JU82_03485 3.82e-157 448.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2YND0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_982000_1 565033.GACE_0100 1.39e-48 166.0 COG5557@1|root,arCOG02025@2157|Archaea,2XWFI@28890|Euryarchaeota,246T1@183980|Archaeoglobi 183980|Archaeoglobi C PFAM Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_982000_2 1379698.RBG1_1C00001G0296 4.07e-83 253.0 COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 k59_1014765_1 1163408.UU9_10027 1.33e-18 90.9 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1X4K0@135614|Xanthomonadales 135614|Xanthomonadales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_491774_1 1168034.FH5T_21070 1.93e-49 166.0 COG1131@1|root,COG1131@2|Bacteria,4NF9C@976|Bacteroidetes,2FNN4@200643|Bacteroidia 976|Bacteroidetes V ABC transporter, ATP-binding protein - - - ko:K01990,ko:K19340 ko02010,map02010 M00254,M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 - - ABC_tran k59_132228_1 1123242.JH636436_gene86 5.96e-19 91.3 COG0608@1|root,COG0608@2|Bacteria,2IXVB@203682|Planctomycetes 203682|Planctomycetes L single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_361204_1 1278309.KB907108_gene1595 7.64e-103 303.0 COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,1RMZ4@1236|Gammaproteobacteria,1XHIZ@135619|Oceanospirillales 135619|Oceanospirillales Q Fumarylacetoacetate (FAA) hydrolase family - - - ko:K02509 ko00350,ko01120,map00350,map01120 - R04132,R06897 RC01615,RC02595 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_884011_1 247634.GPB2148_14 2.05e-42 149.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - 2.7.7.49 ko:K00986,ko:K07497 - - - - ko00000,ko01000 - - - HTH_32,rve,rve_3 k59_34067_1 1121396.KB892924_gene623 5.67e-10 58.5 COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,42NJH@68525|delta/epsilon subdivisions,2WJ6J@28221|Deltaproteobacteria,2MHME@213118|Desulfobacterales 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase, 49 Kd subunit ehrL - - - - - - - - - - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_34067_2 879212.DespoDRAFT_01512 1.98e-54 178.0 COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WJX8@28221|Deltaproteobacteria,2MJAF@213118|Desulfobacterales 28221|Deltaproteobacteria C NADH ubiquinone oxidoreductase, 20 Kd subunit ehrS - - - - - - - - - - iAF987.Gmet_2596 Fer4,Fer4_7,Oxidored_q6 k59_459219_2 906888.JCM19314_3423 7.18e-30 118.0 COG0438@1|root,COG0438@2|Bacteria,4NHHN@976|Bacteroidetes,1HZQ0@117743|Flavobacteriia,3HJAT@363408|Nonlabens 976|Bacteroidetes M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_328469_1 1380391.JIAS01000011_gene4888 2.57e-18 82.0 COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,2JT6Z@204441|Rhodospirillales 204441|Rhodospirillales O HupE / UreJ protein - - - ko:K03192 - - - - ko00000 - - - HupE_UreJ k59_328469_2 709032.Sulku_2036 9.97e-140 401.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2YMJ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KO Hydrogenase hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_132232_1 272560.BPSL1909 3.24e-99 317.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,1K532@119060|Burkholderiaceae 28216|Betaproteobacteria C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_132233_1 1500257.JQNM01000015_gene3013 3.45e-35 137.0 COG3103@1|root,COG4991@2|Bacteria,1QU3X@1224|Proteobacteria,2U23Y@28211|Alphaproteobacteria,4B8HI@82115|Rhizobiaceae 28211|Alphaproteobacteria T Bacterial SH3 domain - - - - - - - - - - - - SH3_3 k59_99541_1 335541.Swol_2256 6.26e-104 328.0 COG0610@1|root,COG0610@2|Bacteria,1TP7S@1239|Firmicutes,248A6@186801|Clostridia,42KDX@68298|Syntrophomonadaceae 186801|Clostridia F Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_393806_1 1168034.FH5T_14745 3.13e-106 324.0 COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,2FMX8@200643|Bacteroidia 976|Bacteroidetes S ABC transporter, ATP-binding protein yfmR - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_720690_1 744979.R2A130_1187 2.58e-27 108.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_720690_2 690585.JNNU01000002_gene4924 3.5e-29 117.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,4BAXT@82115|Rhizobiaceae 28211|Alphaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_557330_1 1165841.SULAR_00590 9.36e-66 215.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2YMJ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mur ligase middle domain murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_982015_1 1038869.AXAN01000016_gene1411 7.99e-67 228.0 COG1158@1|root,COG3064@1|root,COG1158@2|Bacteria,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2VKTY@28216|Betaproteobacteria,1K11H@119060|Burkholderiaceae 28216|Betaproteobacteria M Protein of unknown function (DUF3300) - - - - - - - - - - - - DUF3300 k59_1014777_1 563040.Saut_1828 1.87e-94 301.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 k59_818669_1 1168034.FH5T_01120 5.48e-150 442.0 COG2183@1|root,COG2183@2|Bacteria,4NETD@976|Bacteroidetes,2FMAZ@200643|Bacteroidia 976|Bacteroidetes K Tex-like protein N-terminal domain yhgF - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_72424_1 1165841.SULAR_04848 3.26e-38 137.0 COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,42MVP@68525|delta/epsilon subdivisions,2YMY4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_DAP_Arg_deC k59_72424_2 387093.SUN_1575 7.66e-18 84.7 COG2911@1|root,COG2911@2|Bacteria,1PBYT@1224|Proteobacteria,42T65@68525|delta/epsilon subdivisions,2YPPD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_4419_1 1120951.AUBG01000006_gene435 8.34e-22 89.0 COG0526@1|root,COG0526@2|Bacteria,4NWZR@976|Bacteroidetes 976|Bacteroidetes CO Thioredoxin - - - - - - - - - - - - Thioredoxin k59_4419_2 1111730.ATTM01000005_gene161 9.72e-38 130.0 COG1832@1|root,COG1832@2|Bacteria,4NSE8@976|Bacteroidetes,1I2XU@117743|Flavobacteriia,2NWBD@237|Flavobacterium 976|Bacteroidetes S CoA-binding protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_4419_3 1354300.AUQY01000002_gene869 3.37e-23 93.6 COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,22FWZ@1570339|Peptoniphilaceae 186801|Clostridia H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_562986_1 889378.Spiaf_1112 3e-123 390.0 COG0475@1|root,COG1762@1|root,COG0475@2|Bacteria,COG1762@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system ptsN - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - Na_H_Exchanger,PTS_EIIA_2,Usp k59_725724_1 266264.Rmet_5087 1.21e-77 245.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VJ0J@28216|Betaproteobacteria,1K48A@119060|Burkholderiaceae 28216|Betaproteobacteria E Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_267705_1 387093.SUN_0003 5.27e-94 289.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2YMUF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_758208_1 1163409.UUA_07658 9.97e-158 455.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1X3AN@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_693324_1 709991.Odosp_1045 2.67e-71 229.0 COG0006@1|root,COG0006@2|Bacteria,4NG40@976|Bacteroidetes,2FMSQ@200643|Bacteroidia,22WVB@171551|Porphyromonadaceae 976|Bacteroidetes E Aminopeptidase P, N-terminal domain pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_202933_2 1537917.JU82_05135 4.94e-141 410.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2YMFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_824112_1 743721.Psesu_1900 1.97e-50 178.0 COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X3WH@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_725733_1 573413.Spirs_1865 2.15e-124 362.0 COG2768@1|root,COG2768@2|Bacteria,2J5VC@203691|Spirochaetes 203691|Spirochaetes C 4Fe-4S ferredoxin, iron-sulfur binding - - - ko:K07138 - - - - ko00000 - - - DUF362,Fer4 k59_758211_1 933262.AXAM01000008_gene1971 8.68e-133 387.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2MI2A@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_3528 Seryl_tRNA_N,tRNA-synt_2b k59_138257_1 313603.FB2170_10424 4.25e-88 276.0 COG1473@1|root,COG1473@2|Bacteria,4NEKH@976|Bacteroidetes,1HZT3@117743|Flavobacteriia,2PGP8@252356|Maribacter 976|Bacteroidetes S Peptidase dimerisation domain - - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 k59_725743_1 1165841.SULAR_10574 4.28e-107 315.0 COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2YMNQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_465035_1 1499967.BAYZ01000100_gene3468 1.77e-66 209.0 COG0655@1|root,COG0655@2|Bacteria 2|Bacteria S NAD(P)H dehydrogenase (quinone) activity - - - - - - - - - - - - FMN_red k59_563008_1 335543.Sfum_0547 1.74e-28 113.0 COG1680@1|root,COG1680@2|Bacteria,1QUYZ@1224|Proteobacteria,42PUC@68525|delta/epsilon subdivisions,2WK0V@28221|Deltaproteobacteria,2MRK7@213462|Syntrophobacterales 28221|Deltaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_366746_1 1047013.AQSP01000046_gene1784 0.000124 46.2 COG2801@1|root,COG2801@2|Bacteria,2NQ28@2323|unclassified Bacteria 2|Bacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_431132_1 1168034.FH5T_00025 1.67e-53 175.0 COG0540@1|root,COG0540@2|Bacteria,4NFIU@976|Bacteroidetes,2FN60@200643|Bacteroidia 976|Bacteroidetes F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_334429_1 1265503.KB905166_gene652 1.73e-40 155.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_954417_1 1165841.SULAR_06943 3.07e-127 371.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2YMJU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_334431_1 28229.ND2E_4175 6.17e-32 128.0 COG2203@1|root,COG3221@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3221@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_856884_1 387093.SUN_1149 2.27e-50 166.0 COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,42RBT@68525|delta/epsilon subdivisions,2YNWW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L dna polymerase iii dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_856884_2 1165841.SULAR_05518 1.17e-38 144.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2YN4X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal-transduction protein containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_72462_1 768671.ThimaDRAFT_3683 6.16e-49 160.0 2D3GG@1|root,32TEX@2|Bacteria,1N6JV@1224|Proteobacteria,1SEDU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_72462_2 768671.ThimaDRAFT_3682 3.06e-179 506.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,1RZ0T@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_497601_1 366602.Caul_2969 1.24e-16 86.7 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2KJYY@204458|Caulobacterales 204458|Caulobacterales T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS k59_987586_1 720555.BATR1942_06410 3.23e-62 218.0 COG1020@1|root,COG1028@1|root,COG3321@1|root,COG4221@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HTBC@91061|Bacilli,1ZS7J@1386|Bacillus 91061|Bacilli IQ polyketide synthase - - - ko:K13611,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_628116_1 749222.Nitsa_0329 2.1e-120 357.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2YMG2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_530438_1 32057.KB217483_gene9031 7.83e-20 94.7 COG4995@1|root,COG4995@2|Bacteria,1GDVF@1117|Cyanobacteria 1117|Cyanobacteria U CHAT domain - - - - - - - - - - - - CHAT k59_497608_1 768671.ThimaDRAFT_4897 1.23e-64 212.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria,1WZIC@135613|Chromatiales 135613|Chromatiales L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1 k59_595081_1 314282.PCNPT3_01720 4.41e-13 70.9 COG1846@1|root,COG1846@2|Bacteria,1PC0W@1224|Proteobacteria,1SXNU@1236|Gammaproteobacteria,2QJ6E@267894|Psychromonadaceae 1236|Gammaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - - k59_366769_1 666681.M301_0063 1.7e-62 203.0 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,2KKU7@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM oxidoreductase FAD NAD(P)-binding domain protein - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_202989_1 765911.Thivi_3494 5.3e-41 152.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales 135613|Chromatiales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1020163_1 1391646.AVSU01000015_gene3028 5.87e-25 103.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,25QFN@186804|Peptostreptococcaceae 186801|Clostridia I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_1020163_2 748449.Halha_1655 3.85e-72 228.0 COG0613@1|root,COG0613@2|Bacteria,1VCKE@1239|Firmicutes 1239|Firmicutes S PHP domain - - - - - - - - - - - - PHP,PHP_C k59_1020163_3 883156.HMPREF9282_00475 1.57e-26 110.0 COG0115@1|root,COG0115@2|Bacteria,1V3JS@1239|Firmicutes,4H60F@909932|Negativicutes 909932|Negativicutes EH Amino-transferase class IV - - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k59_1020163_4 572544.Ilyop_0671 2.69e-191 564.0 COG0768@1|root,COG0768@2|Bacteria,37861@32066|Fusobacteria 32066|Fusobacteria M Penicillin-binding protein, transpeptidase domain protein - - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_1020163_5 635013.TherJR_2970 2.36e-107 334.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,26020@186807|Peptococcaceae 186801|Clostridia EH Anthranilate synthase component I pabB - 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01657,ko:K01665,ko:K03342,ko:K13950 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Anth_synt_I_N,Chorismate_bind,GATase k59_1020163_6 469618.FVAG_00619 2.92e-260 744.0 COG1198@1|root,COG1198@2|Bacteria,379NZ@32066|Fusobacteria 32066|Fusobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_563040_1 1055815.AYYA01000055_gene1097 2.31e-09 60.5 COG4461@1|root,COG4461@2|Bacteria,1MZPM@1224|Proteobacteria,1SBGI@1236|Gammaproteobacteria,3NMYP@468|Moraxellaceae 1236|Gammaproteobacteria G 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - - - - - - - - - - LprI k59_563040_2 749222.Nitsa_0126 1.04e-78 247.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2YN43@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_235767_1 1122197.ATWI01000008_gene2982 7.32e-88 272.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,464WH@72275|Alteromonadaceae 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_235767_2 631362.Thi970DRAFT_03958 3.05e-46 163.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1WX31@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_530454_1 1397528.Q671_11430 7.89e-12 63.2 COG3238@1|root,COG3238@2|Bacteria,1PZJ6@1224|Proteobacteria,1TAIX@1236|Gammaproteobacteria,1XQVI@135619|Oceanospirillales 135619|Oceanospirillales S Putative inner membrane exporter, YdcZ - - - - - - - - - - - - DMT_YdcZ k59_530454_2 448385.sce6073 1.33e-65 204.0 COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,42UKT@68525|delta/epsilon subdivisions,2WQR0@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_72486_1 1499968.TCA2_3087 3.55e-40 148.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,26WHR@186822|Paenibacillaceae 91061|Bacilli O Subtilase family - - 3.4.21.66 ko:K08651 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_693387_1 472759.Nhal_3430 1.46e-97 300.0 COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales 135613|Chromatiales M Cell wall hydrolase autolysin - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_72487_1 1151119.KB895489_gene650 6.46e-82 261.0 COG0365@1|root,COG0365@2|Bacteria,2GNE8@201174|Actinobacteria 201174|Actinobacteria I synthetase - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_105575_1 1249627.D779_0564 3.36e-86 265.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales 135613|Chromatiales C TIGRFAM isocitrate dehydrogenase, NADP-dependent - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - CBS,Iso_dh k59_987612_1 1444309.JAQG01000025_gene3817 7.13e-57 192.0 COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,4HAH3@91061|Bacilli,26SUT@186822|Paenibacillaceae 91061|Bacilli E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_105578_1 1298593.TOL_3218 2.54e-19 81.3 COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,1XM23@135619|Oceanospirillales 135619|Oceanospirillales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_105578_2 765912.Thimo_1784 3.19e-13 69.3 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1WX2E@135613|Chromatiales 135613|Chromatiales H Belongs to the FPP GGPP synthase family - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_170826_1 1049564.TevJSym_az00160 5.59e-317 881.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,1RPG4@1236|Gammaproteobacteria,1J5EU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_170826_2 1049564.TevJSym_az00170 0.0 1474.0 COG0074@1|root,COG0074@2|Bacteria,1R4KP@1224|Proteobacteria,1SJJ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Succinyl-CoA ligase like flavodoxin domain - - - - - - - - - - - - CoA_binding,Succ_CoA_lig k59_170826_3 1049564.TevJSym_az00180 1.56e-251 696.0 COG0045@1|root,COG0045@2|Bacteria,1PYM0@1224|Proteobacteria,1SN0X@1236|Gammaproteobacteria 1236|Gammaproteobacteria C ATP citrate lyase citrate-binding - - - - - - - - - - - - ATP-grasp_2,Citrate_bind k59_170826_4 349124.Hhal_2252 1.78e-46 159.0 COG2413@1|root,COG2413@2|Bacteria,1RFTH@1224|Proteobacteria,1T424@1236|Gammaproteobacteria,1X2QN@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_170826_5 1049564.TevJSym_bb00130 0.0 932.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1J4BX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_170826_6 1049564.TevJSym_bb00140 2.78e-161 460.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1J4VC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG4972 Tfp pilus assembly protein, ATPase PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_170826_7 765912.Thimo_0084 6.76e-70 218.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1WY4Z@135613|Chromatiales 135613|Chromatiales NU PFAM Fimbrial assembly - - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_170826_8 1049564.TevJSym_bb00160 5.54e-84 254.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_170826_9 765911.Thivi_2855 6.15e-60 191.0 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1WYAC@135613|Chromatiales 135613|Chromatiales NU pilus assembly protein PilP - - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_170826_10 1049564.TevJSym_bb00180 7.87e-281 796.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1J4IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretory pathway, component pilQ GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_170826_11 1049564.TevJSym_bb00190 5.84e-72 223.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1J6FM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_170826_12 1026882.MAMP_00215 2.32e-165 473.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,4602Z@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_170826_14 1049564.TevJSym_bb00230 0.0 2344.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase domain gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_170826_15 1049564.TevJSym_bb00240 9.06e-292 803.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1J4PB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_170826_16 1049564.TevJSym_at00040 1.56e-215 600.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1J4IA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_170826_17 331678.Cphamn1_1331 1.52e-25 110.0 COG1572@1|root,COG1572@2|Bacteria 2|Bacteria NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - CARDB k59_170826_19 868864.Dester_0447 1.47e-83 259.0 COG2048@1|root,COG2048@2|Bacteria,2G3SY@200783|Aquificae 200783|Aquificae C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K00241,ko:K03389 ko00020,ko00190,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00356,M00357,M00374,M00376,M00563,M00567 R02164,R04540,R11928,R11931,R11943,R11944 RC00011,RC00045 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_856898_1 1049564.TevJSym_aa00020 5.68e-115 333.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1J55G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_856898_2 455436.DS989811_gene1805 1.16e-82 251.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,464IZ@72275|Alteromonadaceae 1236|Gammaproteobacteria J Forms part of the polypeptide exit tunnel rplD GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_856898_3 1049564.TevJSym_aa00040 1.36e-31 113.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1J6R9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_856898_4 2340.JV46_07340 2.43e-143 410.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1J4FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_856898_5 631362.Thi970DRAFT_01961 6.22e-50 159.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1WYHJ@135613|Chromatiales 135613|Chromatiales J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_367304_2 469618.FVAG_02801 2.15e-101 305.0 COG0177@1|root,COG1247@1|root,COG0177@2|Bacteria,COG1247@2|Bacteria,378MA@32066|Fusobacteria 32066|Fusobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Acetyltransf_3,EndIII_4Fe-2S,HhH-GPD k59_889404_1 384765.SIAM614_11688 1.74e-17 82.0 COG0647@1|root,COG0647@2|Bacteria,1RFSZ@1224|Proteobacteria,2U7SF@28211|Alphaproteobacteria 28211|Alphaproteobacteria G UMP catabolic process - - - - - - - - - - - - - k59_889404_2 426117.M446_2296 1.57e-07 52.8 COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2TRRU@28211|Alphaproteobacteria,1JSC1@119045|Methylobacteriaceae 28211|Alphaproteobacteria GK PFAM ROK family mak - 2.7.1.2,2.7.1.4 ko:K00845,ko:K00847 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_726237_1 1304885.AUEY01000024_gene2728 5.54e-57 196.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_693918_1 375286.mma_1308 2.5e-23 104.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,472JA@75682|Oxalobacteraceae 28216|Betaproteobacteria T Large family of predicted nucleotide-binding domains phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_701086_2 525897.Dbac_1224 1.77e-07 49.3 2DIF4@1|root,3031V@2|Bacteria,1QPZG@1224|Proteobacteria,4376Z@68525|delta/epsilon subdivisions,2X0JW@28221|Deltaproteobacteria,2MDUI@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - ko:K03970 - - - - ko00000,ko02048 - - - - k59_211640_1 28258.KP05_11385 9.7e-14 70.5 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1XHXP@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_211640_2 765911.Thivi_0470 1.46e-50 171.0 COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1SYTB@1236|Gammaproteobacteria,1WWFT@135613|Chromatiales 135613|Chromatiales S PFAM oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA k59_211642_1 1167006.UWK_03444 1.09e-10 69.7 COG2197@1|root,COG3852@1|root,COG2197@2|Bacteria,COG3852@2|Bacteria,1R2HI@1224|Proteobacteria,42ZPI@68525|delta/epsilon subdivisions,2WUU1@28221|Deltaproteobacteria,2MPPT@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,PAS_4,Response_reg k59_308069_1 1122225.AULQ01000007_gene2391 5.01e-53 188.0 COG3291@1|root,COG3386@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,HYR,PKD,SprB k59_570528_2 1217718.ALOU01000007_gene1258 3.31e-100 303.0 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2W0N2@28216|Betaproteobacteria 28216|Betaproteobacteria O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_570528_3 1396141.BATP01000001_gene5330 3.07e-61 205.0 28HMZ@1|root,2Z7WD@2|Bacteria,46TFX@74201|Verrucomicrobia,2IVCD@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_112786_5 1217714.F975_02458 9.01e-23 90.5 2EJCP@1|root,33D3P@2|Bacteria,1NGW4@1224|Proteobacteria,1SHA0@1236|Gammaproteobacteria,3NPCT@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_112786_6 76114.ebA3337 3.22e-130 397.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2VJIW@28216|Betaproteobacteria,2KV19@206389|Rhodocyclales 206389|Rhodocyclales L Integrase core domain - - - - - - - - - - - - rve k59_112786_7 1562701.BBOF01000090_gene517 2.38e-90 274.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2VMVE@28216|Betaproteobacteria,1K5SK@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_274516_1 1266908.AQPB01000061_gene1100 0.000236 42.7 COG2143@1|root,COG2143@2|Bacteria,1RB3S@1224|Proteobacteria,1S2A7@1236|Gammaproteobacteria,1WXYQ@135613|Chromatiales 135613|Chromatiales O Thioredoxin-like - - - - - - - - - - - - Thioredoxin_2 k59_274516_2 1122164.JHWF01000036_gene1677 6.69e-27 101.0 COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1JF3B@118969|Legionellales 118969|Legionellales C acylphosphatase activity acyP GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_9471_1 1121445.ATUZ01000013_gene1322 8.02e-28 110.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2M8NE@213115|Desulfovibrionales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa k59_9471_2 1123508.JH636440_gene2451 7.67e-16 79.0 COG1005@1|root,COG1005@2|Bacteria,2IXUX@203682|Planctomycetes 203682|Planctomycetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_471743_1 1049564.TevJSym_au00150 3.73e-24 96.7 COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,1S9YH@1236|Gammaproteobacteria,1J6NP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA hscB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04082 - - - - ko00000,ko03029,ko03110 - - - DnaJ,HSCB_C k59_471743_2 305700.B447_05123 8.11e-47 152.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSKY@28216|Betaproteobacteria,2KWP9@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the HesB IscA family - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_831733_1 1282876.BAOK01000001_gene1498 2.69e-60 196.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,4BP8K@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - 1.5.8.1,1.5.8.2 ko:K00317,ko:K21833 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R01588,R02511 RC00185,RC00556,RC00557,RC00732 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_831733_2 1429851.X548_00580 6.21e-17 75.5 COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,1S6KT@1236|Gammaproteobacteria,1X7NJ@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1428) - - - - - - - - - - - - DUF1428 k59_701105_1 1267535.KB906767_gene4475 1.94e-54 193.0 COG3011@1|root,COG3011@2|Bacteria 2|Bacteria CH Protein conserved in bacteria - - - - - - - - - - - - DUF393,LMF1 k59_79852_1 592026.GCWU0000282_002084 2.57e-46 161.0 COG1690@1|root,COG1690@2|Bacteria,1TPJ2@1239|Firmicutes,2481V@186801|Clostridia 186801|Clostridia S Belongs to the RtcB family - - - - - - - - - - - - RtcB k59_79852_2 469616.FMAG_01918 1.03e-288 803.0 COG0444@1|root,COG0444@2|Bacteria,378W5@32066|Fusobacteria 32066|Fusobacteria EP Belongs to the ABC transporter superfamily - - - - - - - - - - - - - k59_79852_3 572544.Ilyop_0757 4.98e-125 375.0 COG1295@1|root,COG1295@2|Bacteria,3787Z@32066|Fusobacteria 32066|Fusobacteria K Psort location CytoplasmicMembrane, score 10.00 - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_79852_4 1408439.JHXW01000006_gene941 1.72e-67 209.0 COG0779@1|root,COG0779@2|Bacteria,379ZZ@32066|Fusobacteria 32066|Fusobacteria J Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_79852_5 1408439.JHXW01000006_gene940 1.22e-34 129.0 COG0195@1|root,COG0195@2|Bacteria,378QB@32066|Fusobacteria 32066|Fusobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k59_796136_1 1123326.JFBL01000008_gene415 1.38e-40 146.0 COG0642@1|root,COG0642@2|Bacteria,1QZ1Z@1224|Proteobacteria,42SN7@68525|delta/epsilon subdivisions,2YPK7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c k59_539270_1 519989.ECTPHS_04995 3.85e-118 346.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_243759_1 521000.PROVRETT_09905 4.63e-27 119.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,3Z8TP@586|Providencia 1236|Gammaproteobacteria P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB btuB GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696 Plug,TonB_dep_Rec k59_571110_1 572544.Ilyop_1845 1.3e-175 514.0 COG1193@1|root,COG1193@2|Bacteria,378XS@32066|Fusobacteria 32066|Fusobacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_571110_2 1319815.HMPREF0202_01506 5.17e-35 121.0 COG0227@1|root,COG0227@2|Bacteria,37AJS@32066|Fusobacteria 32066|Fusobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB GO:0003674,GO:0003735,GO:0005198 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_571110_3 1216362.B437_01665 7.99e-47 160.0 COG0859@1|root,COG0859@2|Bacteria,378YY@32066|Fusobacteria 32066|Fusobacteria M heptosyltransferase - - - - - - - - - - - - Glyco_transf_9 k59_243760_1 1304885.AUEY01000083_gene2533 2.49e-57 187.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,42STV@68525|delta/epsilon subdivisions,2WKKA@28221|Deltaproteobacteria,2MJB6@213118|Desulfobacterales 28221|Deltaproteobacteria O Tellurite resistance protein TerB - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_733190_1 1196029.ALIM01000034_gene1878 8.81e-97 305.0 COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,1ZCU1@1386|Bacillus 91061|Bacilli L RNA-directed DNA polymerase (reverse transcriptase) - - - - - - - - - - - - HNH,RVT_1 k59_963038_1 387093.SUN_1485 2.39e-50 178.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2YMV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_963038_2 1357400.HMPREF2086_01863 3.88e-05 47.4 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2YMKF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M ABC-type transport system involved in lipoprotein release permease component lolC - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_864428_1 746697.Aeqsu_1491 6.71e-76 248.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,4NDXY@976|Bacteroidetes,1HWZP@117743|Flavobacteriia 976|Bacteroidetes M esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - POTRA,Patatin k59_80404_1 570967.JMLV01000001_gene2644 1.56e-13 71.6 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2TZPK@28211|Alphaproteobacteria,2JRPM@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_80404_2 1046724.KB889893_gene3127 5.52e-95 296.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,46435@72275|Alteromonadaceae 1236|Gammaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon k59_864429_1 1286632.P278_29870 4.79e-41 145.0 COG3637@1|root,COG3637@2|Bacteria,4NMMV@976|Bacteroidetes,1I1GG@117743|Flavobacteriia 976|Bacteroidetes M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_636830_1 555500.I215_13642 1.65e-08 56.2 COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,1HZ84@117743|Flavobacteriia 976|Bacteroidetes G Alpha amylase, catalytic domain amyA - - - - - - - - - - - Alpha-amylase,Alpha-amylase_C k59_636830_2 1168034.FH5T_08540 5.47e-23 97.8 COG0366@1|root,COG0366@2|Bacteria,4NEXF@976|Bacteroidetes,2FMHS@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 13 family amyA2 GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016798,GO:0031216,GO:0044464,GO:0071944 3.2.1.135 ko:K21575 - - - - ko00000,ko01000 - GH13 - Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N k59_507060_1 1168034.FH5T_11385 1.1e-76 238.0 COG0196@1|root,COG0196@2|Bacteria,4NEI9@976|Bacteroidetes,2FM7A@200643|Bacteroidia 976|Bacteroidetes H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_701695_1 573413.Spirs_4181 6.29e-85 257.0 COG0656@1|root,COG0656@2|Bacteria,2J5XV@203691|Spirochaetes 203691|Spirochaetes S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_766794_1 1105367.CG50_16295 6.67e-126 384.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_766794_2 272942.RCAP_rcc02149 2.1e-37 138.0 COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria,1FBW2@1060|Rhodobacter 28211|Alphaproteobacteria S Protein of unknown function (DUF1223) MA20_43790 - - - - - - - - - - - DUF1223 k59_571118_1 243090.RB11273 1.13e-64 211.0 COG0477@1|root,COG2814@2|Bacteria,2J067@203682|Planctomycetes 203682|Planctomycetes EGP Major facilitator superfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_343482_1 177437.HRM2_41440 5.37e-64 208.0 COG0399@1|root,COG0399@2|Bacteria,1PRVB@1224|Proteobacteria,431RA@68525|delta/epsilon subdivisions,2X518@28221|Deltaproteobacteria,2MP3U@213118|Desulfobacterales 28221|Deltaproteobacteria M UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - - - - - - - - - - Y2_Tnp k59_147195_1 314278.NB231_15093 1.03e-19 81.6 COG3360@1|root,COG3360@2|Bacteria 2|Bacteria P Dodecin secE2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K09165 - - - - ko00000 - - - Dodecin k59_147195_2 326298.Suden_1179 9.6e-15 72.8 COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,42VAD@68525|delta/epsilon subdivisions,2YPP1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_23,TehB k59_604366_1 880072.Desac_2296 7.55e-49 174.0 COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MR04@213462|Syntrophobacterales 28221|Deltaproteobacteria S 7TM-HD extracellular - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_604366_2 1265505.ATUG01000001_gene3648 1.08e-33 119.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,42W3M@68525|delta/epsilon subdivisions,2WP9C@28221|Deltaproteobacteria,2MK7D@213118|Desulfobacterales 28221|Deltaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_212177_1 754476.Q7A_2553 6.32e-87 275.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria,460CE@72273|Thiotrichales 72273|Thiotrichales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_604383_1 335543.Sfum_4073 3.47e-12 65.9 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria,2MQVR@213462|Syntrophobacterales 28221|Deltaproteobacteria E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_604383_2 909663.KI867150_gene174 1.88e-107 321.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N5U@68525|delta/epsilon subdivisions,2WKV2@28221|Deltaproteobacteria,2MQ8N@213462|Syntrophobacterales 28221|Deltaproteobacteria P FecCD transport family - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_701713_1 204669.Acid345_0764 9.5e-17 85.5 COG2706@1|root,COG5492@1|root,COG2706@2|Bacteria,COG5492@2|Bacteria,3Y6M8@57723|Acidobacteria,2JMGX@204432|Acidobacteriia 204432|Acidobacteriia GN Galactose oxidase, central domain - - - - - - - - - - - - Kelch_4 k59_113386_1 1121904.ARBP01000005_gene4681 1.2e-90 283.0 COG3119@1|root,COG3119@2|Bacteria,4NIP1@976|Bacteroidetes,47U7R@768503|Cytophagia 976|Bacteroidetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_275080_1 1165841.SULAR_09919 3.62e-82 248.0 COG0602@1|root,COG0602@2|Bacteria,1PDNI@1224|Proteobacteria,42R24@68525|delta/epsilon subdivisions,2YN2N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14 k59_931108_1 96561.Dole_2888 1.03e-21 87.8 COG0727@1|root,COG0727@2|Bacteria 2|Bacteria S metal cluster binding - - - ko:K01163,ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_604387_1 933262.AXAM01000001_gene344 1.4e-12 67.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2MHW2@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_996327_1 177439.DPPB39 3.55e-68 215.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42MBM@68525|delta/epsilon subdivisions,2WJKG@28221|Deltaproteobacteria,2MMK7@213118|Desulfobacterales 28221|Deltaproteobacteria C Transketolase, pyrimidine binding domain pdhB - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2753 Transket_pyr,Transketolase_C k59_996327_2 1121861.KB899911_gene1300 3.62e-35 130.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRW0@28211|Alphaproteobacteria,2JV13@204441|Rhodospirillales 204441|Rhodospirillales C Dehydrogenase E1 component - - - - - - - - - - - - E1_dh k59_212196_2 1049564.TevJSym_ao00750 1.83e-169 479.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1J52U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1077 Actin-like ATPase involved in cell morphogenesis mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_996329_1 749222.Nitsa_2084 1.64e-49 170.0 COG2995@1|root,COG2995@2|Bacteria,1PVTB@1224|Proteobacteria,42W6E@68525|delta/epsilon subdivisions,2YQGG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Paraquat-inducible protein A - - - - - - - - - - - - PqiA k59_897708_1 1249627.D779_0063 6.25e-99 306.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_701728_1 1165841.SULAR_09474 2.54e-113 333.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2YM85@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_N k59_80433_1 1500893.JQNB01000001_gene1800 2.47e-44 165.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1X37J@135614|Xanthomonadales 135614|Xanthomonadales S membrane - - - - - - - - - - - - AsmA_2,DUF3971 k59_80433_2 243233.MCA0381 0.00019 43.9 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1XEP3@135618|Methylococcales 135618|Methylococcales S Carbon-nitrogen hydrolase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_374851_1 768710.DesyoDRAFT_2734 1.04e-60 201.0 COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,2600U@186807|Peptococcaceae 186801|Clostridia F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) - - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_343534_1 1219077.VAZ01S_048_00240 3.65e-36 128.0 COG3208@1|root,COG3208@2|Bacteria,1R0QV@1224|Proteobacteria,1T4NZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Thioesterase involved in non-ribosomal peptide biosynthesis - - - - - - - - - - - - - k59_147225_1 273121.WS0706 7.23e-23 93.6 COG2863@1|root,COG2863@2|Bacteria,1Q3BD@1224|Proteobacteria,42X1X@68525|delta/epsilon subdivisions,2YR1A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_80446_1 1165841.SULAR_05573 5.58e-83 267.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2YN2C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT,HD_4,RelA_SpoT,TGS k59_343541_1 754477.Q7C_1937 1.18e-75 237.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,46093@72273|Thiotrichales 72273|Thiotrichales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_243811_1 1232437.KL662001_gene4593 5.17e-57 187.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,sCache_2 k59_439338_1 243233.MCA1224 1.03e-35 126.0 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1XFE7@135618|Methylococcales 135618|Methylococcales S Tol-Pal system-associated acyl-CoA thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_439338_2 228410.NE0215 1.13e-07 53.1 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,371SV@32003|Nitrosomonadales 28216|Betaproteobacteria U MotA TolQ ExbB proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_791885_1 1223410.KN050846_gene714 7.91e-89 281.0 COG1770@1|root,COG1770@2|Bacteria,4NEQS@976|Bacteroidetes,1HZ57@117743|Flavobacteriia 976|Bacteroidetes E oligopeptidase that cleaves peptide bonds following arginine and lysine residues ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_107794_1 326298.Suden_1758 5.54e-105 318.0 COG0642@1|root,COG0642@2|Bacteria,1N5IQ@1224|Proteobacteria,42M9P@68525|delta/epsilon subdivisions,2YN0U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase cprS - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_565211_1 314287.GB2207_09651 2.52e-85 270.0 COG3291@1|root,COG3291@2|Bacteria,1QU15@1224|Proteobacteria,1T1KN@1236|Gammaproteobacteria,1J4QR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pkd domain containing protein - - - - - - - - - - - - - k59_1022383_2 1502852.FG94_01892 5.55e-42 142.0 COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,2VUWN@28216|Betaproteobacteria,474VE@75682|Oxalobacteraceae 28216|Betaproteobacteria S Invasion gene expression up-regulator, SirB sirB - - - - - - - - - - - SirB k59_1022383_3 1280954.HPO_06368 1.23e-35 127.0 COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,43Y35@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_205450_1 1049564.TevJSym_ax00340 2.56e-97 284.0 COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,1RRM7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_597626_2 360104.CCC13826_1929 3.68e-41 141.0 COG0716@1|root,COG0716@2|Bacteria,1MX7F@1224|Proteobacteria,42Q5G@68525|delta/epsilon subdivisions,2YPA9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Low-potential electron donor to a number of redox enzymes fldA - - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 k59_205453_1 933262.AXAM01000043_gene1185 2.77e-133 388.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,42Q0W@68525|delta/epsilon subdivisions,2WKD6@28221|Deltaproteobacteria,2MJD0@213118|Desulfobacterales 28221|Deltaproteobacteria S HipA N-terminal domain - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_1022394_1 1318628.MARLIPOL_00035 0.000289 49.3 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,465SK@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 13 family pulA - 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 - R02111 - ko00000,ko00001,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3372,PUD k59_74917_1 1115515.EV102420_46_00003 1.12e-06 47.4 2B9ZZ@1|root,323DM@2|Bacteria,1MZ6J@1224|Proteobacteria,1S8U2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG NOG15344 non supervised orthologous group - - - - - - - - - - - - - k59_760120_1 1380354.JIAN01000005_gene1371 1.62e-86 270.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4F12B@85016|Cellulomonadaceae 201174|Actinobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_237874_1 1122137.AQXF01000003_gene2282 7.01e-57 192.0 COG0793@1|root,COG0793@2|Bacteria,1Q6HQ@1224|Proteobacteria,2UHFU@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidase family S41 - - - - - - - - - - - - Peptidase_S41 k59_336906_1 1123257.AUFV01000013_gene2779 6.61e-109 324.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1X7SD@135614|Xanthomonadales 135614|Xanthomonadales L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_205456_1 225849.swp_4916 4.88e-142 412.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q9Q5@267890|Shewanellaceae 1236|Gammaproteobacteria L transposase IS116 IS110 IS902 family protein - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_500093_1 2340.JV46_18710 1.48e-45 149.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1J6QE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363 - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_500093_2 631362.Thi970DRAFT_03826 1.58e-36 129.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1WY1A@135613|Chromatiales 135613|Chromatiales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_173077_1 1168034.FH5T_05180 1.08e-139 404.0 COG4531@1|root,COG4531@2|Bacteria,4NF0R@976|Bacteroidetes 976|Bacteroidetes P Quinol cytochrome c oxidoreductase actF - - - - - - - - - - - - k59_924995_1 236097.ADG881_1324 1.23e-61 200.0 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,1RPFI@1236|Gammaproteobacteria,1XI1M@135619|Oceanospirillales 135619|Oceanospirillales I Acyl-CoA thioesterase tesB - - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_989956_1 1121935.AQXX01000138_gene3179 9.76e-07 52.8 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1XIR3@135619|Oceanospirillales 135619|Oceanospirillales H biosynthesis protein HemY hemY - - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_7 k59_989956_2 1234364.AMSF01000061_gene2078 5.93e-24 100.0 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1X5GD@135614|Xanthomonadales 135614|Xanthomonadales CH COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_565218_1 572544.Ilyop_0266 6.47e-87 262.0 COG0037@1|root,COG0037@2|Bacteria,378FH@32066|Fusobacteria 32066|Fusobacteria H Belongs to the TtcA family - - - - - - - - - - - - ATP_bind_3 k59_565218_2 572544.Ilyop_0267 5.74e-139 402.0 COG0037@1|root,COG0037@2|Bacteria,379SA@32066|Fusobacteria 32066|Fusobacteria H Belongs to the TtcA family - - - - - - - - - - - - ATP_bind_3 k59_565218_3 552811.Dehly_1318 6.61e-60 200.0 COG0226@1|root,COG0226@2|Bacteria,2G7T2@200795|Chloroflexi,34D0R@301297|Dehalococcoidia 301297|Dehalococcoidia P PBP superfamily domain pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_989958_1 177437.HRM2_48880 4.49e-33 129.0 COG3415@1|root,COG3415@2|Bacteria,1QWPC@1224|Proteobacteria,43BU9@68525|delta/epsilon subdivisions,2X75A@28221|Deltaproteobacteria,2MPK9@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_107823_1 1266914.ATUK01000001_gene786 2.25e-41 150.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_107823_2 1286106.MPL1_06084 4.51e-32 122.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,45ZWD@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_924998_1 1168034.FH5T_04270 7.11e-75 234.0 COG0046@1|root,COG0046@2|Bacteria,4NETY@976|Bacteroidetes,2FXM7@200643|Bacteroidia 976|Bacteroidetes F AIR synthase related protein, C-terminal domain purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 k59_5890_1 2340.JV46_16550 3.38e-117 346.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_760137_2 1168034.FH5T_18410 3.43e-75 226.0 COG4770@1|root,COG4770@2|Bacteria,4NSWV@976|Bacteroidetes,2FRYI@200643|Bacteroidia 976|Bacteroidetes I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA mmdC - - - - - - - - - - - Biotin_lipoyl k59_401019_1 1499967.BAYZ01000019_gene6268 1.84e-71 242.0 COG1026@1|root,COG1026@2|Bacteria,2NQI2@2323|unclassified Bacteria 2|Bacteria S Peptidase M16C associated CP_0875 - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C k59_40551_1 243231.GSU3361 0.000124 50.1 COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,42R14@68525|delta/epsilon subdivisions,2WN3R@28221|Deltaproteobacteria,43TZR@69541|Desulfuromonadales 28221|Deltaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_237897_1 1121396.KB893058_gene2563 1.94e-120 352.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WMXZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T response regulator - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_401029_1 391735.Veis_1346 2.43e-07 54.3 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,4AAYE@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM Enoyl-CoA hydratase isomerase - - 4.2.1.18 ko:K13766,ko:K15312 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000,ko01008 - - - ECH_1 k59_467122_2 1049564.TevJSym_bb00010 2.03e-29 113.0 COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_956544_1 1408473.JHXO01000010_gene3584 3.56e-18 77.8 COG0261@1|root,COG0261@2|Bacteria,4NSHE@976|Bacteroidetes,2G2BE@200643|Bacteroidia 976|Bacteroidetes J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - HHH_5,Rho_N,Ribosomal_L21p k59_956544_2 1408473.JHXO01000010_gene3585 3.42e-31 115.0 COG1259@1|root,COG1259@2|Bacteria,4NGSW@976|Bacteroidetes,2FTKZ@200643|Bacteroidia 976|Bacteroidetes S Conserved protein - - - ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR k59_369082_1 1121904.ARBP01000012_gene1171 2.05e-45 166.0 COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,4NHPD@976|Bacteroidetes,47KQD@768503|Cytophagia 976|Bacteroidetes V ABC-2 type transporter - - - ko:K21397 - - - - ko00000,ko02000 3.A.1 - - ABC2_membrane,ABC_tran,TerB k59_925016_2 1216362.B437_08278 1.69e-67 220.0 COG0769@1|root,COG0769@2|Bacteria,37925@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_925020_1 428125.CLOLEP_02777 6.26e-59 206.0 COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,1TT86@1239|Firmicutes,247QE@186801|Clostridia,3WI1V@541000|Ruminococcaceae 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - UvrD-helicase,UvrD_C k59_237903_1 700598.Niako_0299 1.18e-39 142.0 COG0859@1|root,COG0859@2|Bacteria,4NEPH@976|Bacteroidetes,1INZA@117747|Sphingobacteriia 976|Bacteroidetes M Glycosyl transferase, family 9 - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_237903_2 1168034.FH5T_06905 2.2e-36 124.0 COG0355@1|root,COG0355@2|Bacteria,4NUYG@976|Bacteroidetes,2FUIM@200643|Bacteroidia 976|Bacteroidetes C ATP synthase, delta epsilon subunit, beta-sandwich domain protein atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_237903_3 1168034.FH5T_06910 6.67e-98 298.0 COG0055@1|root,COG0055@2|Bacteria,4NF1Q@976|Bacteroidetes,2FP0J@200643|Bacteroidia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_302515_1 929556.Solca_2070 3.28e-45 159.0 COG5002@1|root,COG5002@2|Bacteria,4NETP@976|Bacteroidetes,1IQ3E@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_891308_1 395963.Bind_2416 2.61e-25 102.0 2E2NU@1|root,32XRU@2|Bacteria,1N1V4@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_891308_2 1137799.GZ78_13955 5.41e-62 197.0 COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,1RMZ7@1236|Gammaproteobacteria,1XJDP@135619|Oceanospirillales 135619|Oceanospirillales J synthase truC - 5.4.99.26 ko:K06175 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_2 k59_695426_1 1232410.KI421418_gene2263 6.94e-51 168.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,43SW0@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_5907_1 269799.Gmet_3551 1.94e-73 238.0 COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria,43SUB@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_727716_1 1163617.SCD_n01169 7.89e-71 221.0 COG2020@1|root,COG2020@2|Bacteria,1PPQV@1224|Proteobacteria,2VR3S@28216|Betaproteobacteria 28216|Betaproteobacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - - k59_663537_1 330214.NIDE3284 1.59e-14 80.1 COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,3J117@40117|Nitrospirae 40117|Nitrospirae T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - DUF3365,HAMP,HATPase_c,HisKA,PAS_4 k59_140791_1 926559.JoomaDRAFT_2288 2.32e-13 72.0 COG4225@1|root,COG4225@2|Bacteria,4NH7G@976|Bacteroidetes,1HZNV@117743|Flavobacteriia 976|Bacteroidetes S Glycosyl Hydrolase Family 88 yteR_9 - - - - - - - - - - - Glyco_hydro_88,Lipase_GDSL_2 k59_173132_1 886882.PPSC2_c3389 6.08e-85 284.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksJ - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_401053_1 123214.PERMA_1678 1.1e-66 222.0 COG0441@1|root,COG0441@2|Bacteria,2G3SG@200783|Aquificae 200783|Aquificae J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_826312_1 748449.Halha_1492 9.44e-125 369.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,3WBBP@53433|Halanaerobiales 186801|Clostridia E Flavin containing amine oxidoreductase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_925033_1 105559.Nwat_0670 7.52e-69 226.0 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1WWVY@135613|Chromatiales 135613|Chromatiales T PFAM MucB RseB - - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_760178_1 861299.J421_4066 5.79e-33 130.0 COG0515@1|root,COG0515@2|Bacteria,1ZTGA@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_173134_1 698758.AXY_12410 5.22e-27 110.0 COG1352@1|root,COG1352@2|Bacteria,1TPD8@1239|Firmicutes,4HAS1@91061|Bacilli 91061|Bacilli NT Chemotaxis protein CheR cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_695438_1 697282.Mettu_3861 9.83e-145 421.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales 135618|Methylococcales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_597693_1 395964.KE386496_gene1217 4.32e-31 118.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TTN3@28211|Alphaproteobacteria,3NA9E@45404|Beijerinckiaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component oppB - - ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_597693_2 748658.KB907314_gene127 5.82e-76 250.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales 135613|Chromatiales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_925037_1 493475.GARC_4153 1.59e-07 59.3 COG4774@1|root,COG4774@2|Bacteria,1PIT1@1224|Proteobacteria,1SKRR@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Outer membrane receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_630365_1 1049564.TevJSym_ao00790 1.25e-268 744.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1J4IG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_630365_2 743720.Psefu_3695 3.29e-31 112.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1YYV8@136845|Pseudomonas putida group 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_630365_3 1049564.TevJSym_ao00750 3.88e-211 588.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1J52U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1077 Actin-like ATPase involved in cell morphogenesis mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_630365_4 631362.Thi970DRAFT_03320 4.93e-85 263.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1WWKS@135613|Chromatiales 135613|Chromatiales M Involved in formation and maintenance of cell shape - - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_630365_5 765913.ThidrDRAFT_0191 1.1e-41 144.0 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales 135613|Chromatiales M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_630365_6 1049564.TevJSym_ao00720 1e-264 745.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1J4EU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_630365_7 1249627.D779_0062 4.21e-152 440.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_630365_8 1207076.ALAT01000011_gene1548 2.46e-89 278.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1Z1UZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M lytic murein transglycosylase B mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_630365_9 765914.ThisiDRAFT_1435 1.77e-76 241.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1WW9X@135613|Chromatiales 135613|Chromatiales M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_630365_10 1049564.TevJSym_ao00680 5.06e-157 453.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1J4UD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S11 family dacA GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - iEC55989_1330.EC55989_2269,iSFV_1184.SFV_0694,iSbBS512_1146.SbBS512_E2506,iYL1228.KPN_00664 PBP5_C,Peptidase_S11 k59_630365_11 713586.KB900536_gene2646 1.6e-108 323.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_630365_12 546274.EIKCOROL_00021 6.24e-24 93.6 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,2KRKX@206351|Neisseriales 206351|Neisseriales S Belongs to the UPF0250 family - - - ko:K09158 - - - - ko00000 - - - DUF493 k59_630365_13 998674.ATTE01000001_gene122 9.32e-80 244.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,460KH@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_630365_14 857087.Metme_1604 1.2e-90 295.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_630365_15 1249627.D779_1914 1.62e-44 148.0 COG2010@1|root,COG2010@2|Bacteria,1NDHN@1224|Proteobacteria,1S700@1236|Gammaproteobacteria,1WYGG@135613|Chromatiales 135613|Chromatiales C Planctomycete cytochrome C - - - - - - - - - - - - PSCyt1 k59_630365_16 398578.Daci_2749 2.82e-21 87.8 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,4AEW8@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Cytochrome c, class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_630365_17 156889.Mmc1_0813 3.09e-160 457.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_630365_18 1049564.TevJSym_ao00650 5.1e-172 487.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1J5F5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_630365_19 640081.Dsui_2924 3e-47 164.0 COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2VSTA@28216|Betaproteobacteria,2KWND@206389|Rhodocyclales 206389|Rhodocyclales S DUF218 domain - - - - - - - - - - - - DUF218 k59_1022556_72 1049564.TevJSym_aw00140 7.17e-117 340.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - - - - - - - - - - - Nitrate_red_gam k59_891908_1 1121396.KB893053_gene2370 1.13e-55 183.0 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,42RMS@68525|delta/epsilon subdivisions,2WNG3@28221|Deltaproteobacteria,2MIBV@213118|Desulfobacterales 28221|Deltaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_664071_2 713587.THITH_13160 1.16e-29 109.0 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,1WZ6P@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0125 (RnfH) family - - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_896551_65 472759.Nhal_3283 2.51e-221 622.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1WX6X@135613|Chromatiales 135613|Chromatiales C Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_896551_66 1049564.TevJSym_bj00020 5.21e-221 623.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1J4II@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008219,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0012501,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016779,GO:0019200,GO:0033692,GO:0033785,GO:0033786,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0070566,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272,ko:K21344 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECH74115_1262.ECH74115_4363,iECSP_1301.ECSP_4025,iECs_1301.ECs3935,iPC815.YPO0654,iZ_1308.Z4405 CTP_transf_like,PfkB k59_896551_67 1182590.BN5_00485 1.61e-31 122.0 COG0515@1|root,COG0515@2|Bacteria,1RF4R@1224|Proteobacteria,1S7ZX@1236|Gammaproteobacteria,1YG4D@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria KLT Lipopolysaccharide kinase (Kdo/WaaP) family - - - - - - - - - - - - Kdo k59_896551_68 1049564.TevJSym_at00310 3.1e-263 742.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RYF4@1236|Gammaproteobacteria,1J8MZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria GM Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_2 k59_896551_70 1221522.B723_08400 3.22e-128 377.0 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria,1YNUC@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M Glycosyl transferase family 4 wbpL - - ko:K13007 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_896551_71 399739.Pmen_1874 5.84e-119 352.0 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,1RPHW@1236|Gammaproteobacteria,1YCU7@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria GM Male sterility protein wbpV - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_896551_72 399739.Pmen_1873 4.09e-215 600.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,1RPNC@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues wecB - 3.2.1.183,5.1.3.14 ko:K01791,ko:K08068 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_896551_73 658612.MD26_04360 2.05e-202 565.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM Polysaccharide biosynthesis protein fnlA - 5.1.3.2 ko:K17716 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00362 R00291 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Polysacc_syn_2C,Polysacc_synt_2 k59_896551_74 220664.PFL_5105 2.86e-116 342.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNZ@1236|Gammaproteobacteria,1YRHU@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria C Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_896551_75 1207075.PputUW4_01374 8.11e-164 473.0 COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,1RS9J@1236|Gammaproteobacteria 1236|Gammaproteobacteria M glycosyl transferase group 1 wcaI - - ko:K03208 - - - - ko00000 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_700548_1 1045855.DSC_00980 1.63e-06 51.2 COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,1SXVV@1236|Gammaproteobacteria,1X6VJ@135614|Xanthomonadales 135614|Xanthomonadales J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_700548_2 187272.Mlg_0001 7.81e-72 231.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales 135613|Chromatiales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_373823_1 926569.ANT_30160 1.83e-91 278.0 COG0156@1|root,COG0156@2|Bacteria,2G65Q@200795|Chloroflexi 200795|Chloroflexi H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_930127_1 261292.Nit79A3_2206 2.76e-90 273.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,371XV@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_961988_1 2340.JV46_13150 7.73e-125 372.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_765718_2 1392493.JIAB01000001_gene644 4.07e-18 84.3 COG0438@1|root,COG0438@2|Bacteria,1VJJB@1239|Firmicutes,24KPG@186801|Clostridia 186801|Clostridia M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 k59_9022_1 500633.CLOHIR_00520 2.06e-08 60.5 COG1401@1|root,COG1401@2|Bacteria,1TPIP@1239|Firmicutes,249RD@186801|Clostridia,25S5J@186804|Peptostreptococcaceae 186801|Clostridia V ATPase family associated with various cellular activities (AAA) mcrB - - ko:K07452 - - - - ko00000,ko01000,ko02048 - - - AAA_5,EVE,Mrr_N k59_570071_1 1380386.JIAW01000009_gene5344 1.45e-11 67.8 COG2813@1|root,COG2813@2|Bacteria,2I4F5@201174|Actinobacteria,234KU@1762|Mycobacteriaceae 201174|Actinobacteria J Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_406074_1 1123252.ATZF01000011_gene3255 3.11e-14 68.6 COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,4HKH9@91061|Bacilli,27BWP@186824|Thermoactinomycetaceae 91061|Bacilli J Ribosomal proteins 50S L24/mitochondrial 39S L24 rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_406074_2 1313301.AUGC01000006_gene105 4.8e-32 118.0 COG0094@1|root,COG0094@2|Bacteria,4NEGY@976|Bacteroidetes 976|Bacteroidetes J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_863391_1 90813.JQMT01000001_gene1 1.48e-52 209.0 COG2304@1|root,COG2373@1|root,COG4254@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG4254@2|Bacteria,COG4932@2|Bacteria,1QU09@1224|Proteobacteria,1T271@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU domain protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2 k59_178659_1 1123073.KB899241_gene1809 1.98e-24 97.8 2E9U9@1|root,33407@2|Bacteria,1N524@1224|Proteobacteria,1SASS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized conserved protein (DUF2304) - - - ko:K09153 - - - - ko00000 - - - DUF2304 k59_242702_1 497321.C664_17110 3.48e-67 223.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,2KVP5@206389|Rhodocyclales 206389|Rhodocyclales I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_146145_1 1038922.PflQ2_5518 4.3e-37 142.0 COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,1RNX1@1236|Gammaproteobacteria,1YMR2@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria MU type I secretion outer membrane aggA - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP,OmpA k59_438228_2 1286632.P278_01590 5.69e-62 190.0 COG0051@1|root,COG0051@2|Bacteria,4NQ65@976|Bacteroidetes,1I2VK@117743|Flavobacteriia 976|Bacteroidetes J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_603284_1 765914.ThisiDRAFT_0806 1.07e-113 340.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1WWUV@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_603284_2 2340.JV46_23750 3.96e-14 74.7 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1J58M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III delta subunit holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_795246_2 235985.BBPN01000002_gene5107 1.88e-08 61.2 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,2NGTU@228398|Streptacidiphilus 201174|Actinobacteria L PD-(D/E)XK nuclease superfamily uvrD3 - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_668943_1 395495.Lcho_0364 9.76e-15 73.6 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2VI6Z@28216|Betaproteobacteria,1KKF3@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Thioredoxin - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_668943_2 555779.Dthio_PD2250 2.17e-44 157.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42R8Z@68525|delta/epsilon subdivisions,2WMXX@28221|Deltaproteobacteria,2MAE4@213115|Desulfovibrionales 28221|Deltaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin,cNMP_binding k59_962011_1 1165841.SULAR_08362 2.27e-101 302.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2YN3J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_732196_1 1411685.U062_00783 6.2e-35 133.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1J4WN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_406089_1 1172190.M947_02710 1.43e-63 216.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,42MYF@68525|delta/epsilon subdivisions,2YMXD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Single-stranded-DNA-specific exonuclease (RecJ) recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_274082_1 1120953.AUBH01000011_gene456 9.91e-110 347.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1MX41@1224|Proteobacteria,1RP38@1236|Gammaproteobacteria,465NW@72275|Alteromonadaceae 1236|Gammaproteobacteria M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_603291_1 472759.Nhal_2148 8.33e-42 148.0 COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,1RSFF@1236|Gammaproteobacteria 1236|Gammaproteobacteria A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_603291_2 697282.Mettu_0212 7.74e-27 103.0 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,1XFGU@135618|Methylococcales 135618|Methylococcales S Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_45042_1 765913.ThidrDRAFT_2793 4.41e-05 45.1 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1WY08@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_505959_1 1408813.AYMG01000012_gene1047 4.48e-23 97.8 COG2730@1|root,COG2730@2|Bacteria,4NF3J@976|Bacteroidetes,1IRPS@117747|Sphingobacteriia 976|Bacteroidetes G Putative collagen-binding domain of a collagenase - - - - - - - - - - - - Collagen_bind_2,DUF4038 k59_505959_2 926556.Echvi_0929 7.34e-100 298.0 COG1621@1|root,COG1621@2|Bacteria,4NHR9@976|Bacteroidetes,47M2F@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_32N,Glyco_hydro_43 k59_570095_1 338963.Pcar_2557 4.4e-94 298.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,43UHA@69541|Desulfuromonadales 28221|Deltaproteobacteria M Bifunctional transglycosylase second domain mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_211094_1 1283300.ATXB01000001_gene387 1.69e-98 298.0 COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,1RP9M@1236|Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - Patatin k59_995919_1 1265505.ATUG01000002_gene2154 7.69e-14 76.3 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,42W78@68525|delta/epsilon subdivisions,2WRWC@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3' - - - ko:K03556 - - - - ko00000,ko03000 - - - BTAD,GerE k59_45606_2 1168034.FH5T_18315 3.77e-49 169.0 COG0673@1|root,COG0673@2|Bacteria,4NIF1@976|Bacteroidetes,2FX47@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_506687_1 1049564.TevJSym_cb00050 2.64e-91 291.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_211769_1 335543.Sfum_3600 3.64e-13 72.0 COG4871@1|root,COG4871@2|Bacteria,1RF0E@1224|Proteobacteria,42RKU@68525|delta/epsilon subdivisions,2WNHT@28221|Deltaproteobacteria,2MRPZ@213462|Syntrophobacterales 28221|Deltaproteobacteria C Putative Fe-S cluster - - - - - - - - - - - - FeS k59_112929_1 641491.DND132_2717 8.38e-33 127.0 COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria,2M9NW@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM natural resistance-associated macrophage protein mntH - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp,Usp k59_308198_1 867903.ThesuDRAFT_01285 2.22e-101 322.0 COG1203@1|root,COG1203@2|Bacteria,1TQ9B@1239|Firmicutes,248UE@186801|Clostridia,3WD49@538999|Clostridiales incertae sedis 186801|Clostridia L Metal dependent phosphohydrolases with conserved 'HD' motif. cas3 - - ko:K07012 - - - - ko00000,ko01000,ko02048 - - - DEAD,HD,Helicase_C,ResIII k59_864026_1 428125.CLOLEP_02760 2.24e-21 99.0 COG4733@1|root,COG4733@2|Bacteria,1UYQE@1239|Firmicutes,24C16@186801|Clostridia,3WI7H@541000|Ruminococcaceae 186801|Clostridia G Parallel beta-helix repeats - - - - - - - - - - - - CBM_6,Dockerin_1,Laminin_G_3 k59_506692_1 4572.TRIUR3_00336-P1 1.51e-133 391.0 COG1007@1|root,KOG4668@2759|Eukaryota,37KVW@33090|Viridiplantae,3GH1R@35493|Streptophyta,3KR9M@4447|Liliopsida,3I881@38820|Poales 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhB - 1.6.5.3 ko:K05573 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Proton_antipo_M k59_930765_1 1172190.M947_04705 2.01e-19 82.4 COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,42V9C@68525|delta/epsilon subdivisions,2YQ7A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_930765_2 1172190.M947_04710 2.62e-26 108.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2YMGZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_406711_2 572477.Alvin_2343 1.34e-255 709.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales 135613|Chromatiales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_406711_3 2340.JV46_07180 6.86e-72 219.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,1J6F0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_406711_4 2340.JV46_07190 1.11e-24 93.6 COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,1J78G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Ribosomal protein L30p/L7e rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_406711_5 765912.Thimo_2843 2.96e-89 265.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,1WX2D@135613|Chromatiales 135613|Chromatiales J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_406711_6 2340.JV46_07210 6.42e-51 164.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,1J664@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_406711_7 765911.Thivi_4216 1.43e-82 248.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,1WXV2@135613|Chromatiales 135613|Chromatiales J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_406711_8 1279015.KB908469_gene331 5.66e-60 187.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,1Y4DI@135624|Aeromonadales 135624|Aeromonadales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_406711_9 203122.Sde_0972 2.49e-47 153.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,467UW@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_406711_10 754476.Q7A_2310 5.45e-97 285.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,460DF@72273|Thiotrichales 72273|Thiotrichales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_831858_1 1262449.CP6013_3886 2.66e-05 45.1 COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,36G34@31979|Clostridiaceae 186801|Clostridia C alcohol dehydrogenase - - - ko:K19955 - - - - ko00000,ko01000 - - - Fe-ADH k59_831858_2 1458462.JNLK01000001_gene2489 4.08e-40 137.0 2DKAK@1|root,32UER@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_831858_3 471875.RUMLAC_01598 1.11e-60 189.0 COG1917@1|root,COG1917@2|Bacteria,1TRVH@1239|Firmicutes,249JY@186801|Clostridia,3WGGH@541000|Ruminococcaceae 186801|Clostridia S Cupin domain - - - - - - - - - - - - Cupin_2 k59_795782_1 1165841.SULAR_10254 3.2e-88 275.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2YN5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_930770_1 34506.g6059 2.35e-88 291.0 COG0481@1|root,COG0571@1|root,COG1159@1|root,KOG0462@2759|Eukaryota,KOG1423@2759|Eukaryota,KOG1817@2759|Eukaryota,38H35@33154|Opisthokonta,3BWUB@33208|Metazoa,3DDYP@33213|Bilateria,40QZN@6231|Nematoda,1M7YV@119089|Chromadorea,4172X@6236|Rhabditida 33208|Metazoa J GTP-binding protein LepA C-terminus - - - - - - - - - - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_766381_1 765911.Thivi_2846 3.96e-83 260.0 COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,1S0QY@1236|Gammaproteobacteria,1WXB1@135613|Chromatiales 135613|Chromatiales J S1, RNA binding domain - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_795783_1 203275.BFO_0948 1.57e-27 108.0 COG1280@1|root,COG1280@2|Bacteria,4NMR9@976|Bacteroidetes,2FM4B@200643|Bacteroidia,22XRM@171551|Porphyromonadaceae 976|Bacteroidetes E Translocator protein, LysE family - - - - - - - - - - - - LysE k59_795783_2 1168034.FH5T_17355 1.3e-35 134.0 COG0457@1|root,COG0457@2|Bacteria,4NFFS@976|Bacteroidetes,2FMYG@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_12,TPR_16,TPR_19,TPR_6,TPR_7,TPR_8 k59_506702_2 572544.Ilyop_1692 3.49e-22 94.7 COG0334@1|root,COG0334@2|Bacteria,378XT@32066|Fusobacteria 32066|Fusobacteria C Belongs to the Glu Leu Phe Val dehydrogenases family gluD - 1.4.1.2,1.4.1.4 ko:K00260,ko:K00262 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_538876_1 616991.JPOO01000001_gene4013 3.14e-87 273.0 COG4198@1|root,COG4198@2|Bacteria,4NGWT@976|Bacteroidetes,1I0YB@117743|Flavobacteriia 976|Bacteroidetes S Starch-binding associating with outer membrane - - - - - - - - - - - - SusD-like_2 k59_243331_1 563040.Saut_0642 6.62e-51 166.0 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,42RE5@68525|delta/epsilon subdivisions,2YSYY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S SEC-C motif - - - ko:K09858 - - - - ko00000 - - - SEC-C k59_1027528_1 391626.OAN307_c03800 2.18e-53 179.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2826 Transposase and inactivated derivatives, IS30 family - - - - - - - - - - - - HTH_38,rve k59_701275_1 243233.MCA1545 1.04e-167 506.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales 135618|Methylococcales H Vitamin B12 dependent methionine synthase, activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_545015_1 886379.AEWI01000005_gene963 1.62e-38 147.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,2FNH9@200643|Bacteroidia,3XJ8U@558415|Marinilabiliaceae 976|Bacteroidetes E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_903787_1 357804.Ping_3448 1.7e-10 65.5 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,2QI2J@267894|Psychromonadaceae 1236|Gammaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_903787_2 888050.HMPREF9004_1294 3.04e-28 108.0 COG0222@1|root,COG0222@2|Bacteria,2IKNW@201174|Actinobacteria,4D602@85005|Actinomycetales 201174|Actinobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_642902_1 1168034.FH5T_16625 4.76e-177 501.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,4NF6I@976|Bacteroidetes,2FNS0@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_478421_1 1123326.JFBL01000001_gene1399 2.84e-71 226.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2YMQJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_249910_1 1442598.JABW01000031_gene1248 1.85e-27 103.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2YMFC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_249910_2 929558.SMGD1_2304 5.36e-64 199.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2YPEP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_249910_3 1249480.B649_08695 2.34e-22 92.4 COG0607@1|root,COG4802@1|root,COG0607@2|Bacteria,COG4802@2|Bacteria,1QYD3@1224|Proteobacteria,42PN1@68525|delta/epsilon subdivisions,2YMYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP PFAM Ferredoxin thioredoxin reductase catalytic beta chain - - - - - - - - - - - - FeThRed_B,Rhodanese k59_16373_1 1168034.FH5T_00305 2.39e-51 174.0 COG0642@1|root,COG0642@2|Bacteria 2|Bacteria T Histidine kinase prpE2 - - - - - - - - - - - HATPase_c,HATPase_c_2,HisKA,PAS_4,SpoIIE k59_937072_1 765914.ThisiDRAFT_1219 6.32e-64 217.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_413145_1 983544.Lacal_2682 1.59e-79 247.0 COG0448@1|root,COG0448@2|Bacteria,4NDVJ@976|Bacteroidetes,1HYK5@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_413145_2 1250006.JHZZ01000001_gene1834 1.47e-30 117.0 COG0297@1|root,COG0297@2|Bacteria,4PKP8@976|Bacteroidetes,1I0SF@117743|Flavobacteriia,3VW3Q@52959|Polaribacter 976|Bacteroidetes G Starch synthase catalytic domain - - - - - - - - - - - - Glyco_transf_4,Glyco_transf_5,Glycos_transf_1 k59_249928_1 338969.Rfer_1011 5.76e-05 50.8 COG0318@1|root,COG1309@1|root,COG0318@2|Bacteria,COG1309@2|Bacteria,1MU6G@1224|Proteobacteria,2VH80@28216|Betaproteobacteria,4A9WB@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.26,6.2.1.34 ko:K01911,ko:K12508 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_185891_1 998088.B565_1317 7.64e-24 105.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1Y3X8@135624|Aeromonadales 135624|Aeromonadales M Transglycosylase SLT domain - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_838388_2 1217714.F975_01406 5.23e-128 387.0 COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,1S1GX@1236|Gammaproteobacteria,3NIRC@468|Moraxellaceae 1236|Gammaproteobacteria L Helix-turn-helix domain pif1 - - - - - - - - - - - HTH_40,PIF1 k59_445547_1 1163408.UU9_01304 1.64e-08 62.0 COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,1X4W4@135614|Xanthomonadales 135614|Xanthomonadales P Iron permease - - - - - - - - - - - - Cytochrome_CBB3,FTR1 k59_185897_1 563040.Saut_0299 4.08e-69 210.0 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,42SBM@68525|delta/epsilon subdivisions,2YPGH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_185897_2 1249480.B649_10790 1.53e-75 226.0 COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,42SE0@68525|delta/epsilon subdivisions,2YPJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx k59_739108_1 1319815.HMPREF0202_02979 6.6e-65 212.0 COG0312@1|root,COG0312@2|Bacteria,37BXT@32066|Fusobacteria 32066|Fusobacteria S Putative modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD k59_739108_2 926561.KB900620_gene3096 4.76e-24 93.6 COG0347@1|root,COG0347@2|Bacteria,1V9Z5@1239|Firmicutes,24MNA@186801|Clostridia 186801|Clostridia K Belongs to the P(II) protein family glnB - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_937092_1 1265313.HRUBRA_00889 6.67e-122 352.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Integrase - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_545048_1 1123256.KB907934_gene2393 4.39e-58 199.0 COG4805@1|root,COG4805@2|Bacteria,1PIM6@1224|Proteobacteria,1RRW7@1236|Gammaproteobacteria,1X3BX@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_185901_2 1379281.AVAG01000035_gene1756 1.66e-106 311.0 COG2191@1|root,COG2191@2|Bacteria,1RC3D@1224|Proteobacteria,42QXB@68525|delta/epsilon subdivisions,2WMUZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - 1.2.7.12 ko:K11261 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - FmdE,zf-dskA_traR k59_314644_1 1487921.DP68_07660 3.85e-153 452.0 COG0038@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0569@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,36FR4@31979|Clostridiaceae 186801|Clostridia P Chloride channel clcA - - - - - - - - - - - TrkA_C,Voltage_CLC k59_249948_1 1128398.Curi_c17620 1.78e-60 200.0 COG1362@1|root,COG1362@2|Bacteria,1TQ3Z@1239|Firmicutes,248UP@186801|Clostridia,268K1@186813|unclassified Clostridiales 186801|Clostridia E Aminopeptidase I zinc metalloprotease (M18) apeB - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k59_445549_1 1158607.UAU_03004 4.65e-138 414.0 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1TPJ8@1239|Firmicutes,4HA8X@91061|Bacilli,4AZCR@81852|Enterococcaceae 91061|Bacilli G phosphotransferase system, EIIB malX - 2.7.1.199,2.7.1.208 ko:K02790,ko:K02791 ko00010,ko00500,ko00520,ko02060,map00010,map00500,map00520,map02060 M00266 R02738,R04111 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.3 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_802364_2 1216362.B437_00990 4.22e-129 378.0 COG1902@1|root,COG1902@2|Bacteria,378MJ@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score - - - - - - - - - - - - Oxidored_FMN k59_802364_3 572544.Ilyop_0880 2.29e-79 241.0 COG1658@1|root,COG1658@2|Bacteria,378UX@32066|Fusobacteria 32066|Fusobacteria J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step rnmV GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043822,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 3.1.26.8 ko:K05985 - - - - ko00000,ko01000 - - - DUF4093,Toprim,Toprim_4 k59_802364_4 1469948.JPNB01000003_gene143 6.39e-54 178.0 COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,36I75@31979|Clostridiaceae 186801|Clostridia L Belongs to the DNA glycosylase MPG family - - 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco k59_119759_2 292415.Tbd_2572 3.15e-42 152.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1KSMD@119069|Hydrogenophilales 119069|Hydrogenophilales M Mur ligase family, catalytic domain - - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_642932_1 1168034.FH5T_06675 3.71e-46 165.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,2FMI7@200643|Bacteroidia 976|Bacteroidetes E 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_642932_2 1168034.FH5T_06680 9.4e-82 250.0 COG0685@1|root,COG0685@2|Bacteria,4NDY0@976|Bacteroidetes,2FMPC@200643|Bacteroidia 976|Bacteroidetes C Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1002488_1 1168034.FH5T_19635 6.83e-61 205.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,2FNBA@200643|Bacteroidia 976|Bacteroidetes EU Peptidase, S9A B C family, catalytic domain protein dpp - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 k59_1002488_2 888832.HMPREF9420_2333 3.34e-16 79.3 COG0861@1|root,COG0861@2|Bacteria,4NH7P@976|Bacteroidetes,2FS6S@200643|Bacteroidia 976|Bacteroidetes P integral membrane protein, TerC family - - - ko:K05794 - - - - ko00000 - - - TerC k59_610336_1 1354314.CHV_a0493 1.19e-05 52.8 COG3422@1|root,COG3422@2|Bacteria,4NHE4@976|Bacteroidetes,47NKA@768503|Cytophagia 976|Bacteroidetes H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - - - - - - - - - - - - k59_838409_1 1249480.B649_08720 4.66e-69 224.0 COG4972@1|root,COG4972@2|Bacteria,1QA6M@1224|Proteobacteria,42NDB@68525|delta/epsilon subdivisions,2YMP2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Pilus assembly protein - - - - - - - - - - - - - k59_381069_1 1042375.AFPL01000008_gene3151 5.95e-101 313.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,4650A@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - iSSON_1240.SSON_0092 PBP_dimer,Transpeptidase k59_969332_1 1125863.JAFN01000001_gene1028 7.92e-129 388.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_676328_1 335543.Sfum_1959 2.16e-63 203.0 COG0725@1|root,COG0725@2|Bacteria,1NN9I@1224|Proteobacteria,42M3Q@68525|delta/epsilon subdivisions,2WJDA@28221|Deltaproteobacteria,2MRCY@213462|Syntrophobacterales 28221|Deltaproteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_577433_1 1485544.JQKP01000002_gene1538 3.74e-54 176.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,44VA6@713636|Nitrosomonadales 28216|Betaproteobacteria L Endonuclease/Exonuclease/phosphatase family xthA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_802378_1 1506583.JQJY01000002_gene1806 8.13e-45 164.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia,2NV6N@237|Flavobacterium 976|Bacteroidetes G Domain of unknown function (DUF4982) - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Malectin k59_513226_1 929506.CbC4_2036 5.29e-76 254.0 COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,36DHY@31979|Clostridiaceae 186801|Clostridia J elongation factor G tetP - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,NYN_YacP k59_1033841_1 1122603.ATVI01000006_gene503 3.6e-55 185.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1X3US@135614|Xanthomonadales 135614|Xanthomonadales NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_1002508_1 1004149.AFOE01000033_gene709 5.5e-11 65.5 COG3250@1|root,COG3250@2|Bacteria,4NEP8@976|Bacteroidetes,1HZ78@117743|Flavobacteriia 976|Bacteroidetes G Glycosyl hydrolases family 2, sugar binding domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_1002508_2 1168034.FH5T_00940 6.02e-14 72.0 COG3250@1|root,COG3250@2|Bacteria,4NESZ@976|Bacteroidetes,2FPDW@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_86661_1 827.JFJK01000005_gene1179 1.77e-38 138.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42R15@68525|delta/epsilon subdivisions,2YNVA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_86661_2 563040.Saut_1061 1.54e-15 74.3 2AJ5D@1|root,319PZ@2|Bacteria,1Q3HS@1224|Proteobacteria,42XCD@68525|delta/epsilon subdivisions,2YQQ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Chemotaxis phosphatase CheX - - - - - - - - - - - - CheX k59_381083_2 13735.ENSPSIP00000020470 4.5e-23 99.4 KOG3105@1|root,KOG3105@2759|Eukaryota,38I47@33154|Opisthokonta,3BMCH@33208|Metazoa,3CYY1@33213|Bilateria,48700@7711|Chordata,4949I@7742|Vertebrata,4CCEH@8459|Testudines 33208|Metazoa BD Brinker DNA-binding domain POGK - - - - - - - - - - - BrkDBD,DDE_1,HTH_Tnp_Tc5,KRAB k59_513231_1 709032.Sulku_2279 3.31e-76 237.0 COG3022@1|root,COG3022@2|Bacteria,1Q5IV@1224|Proteobacteria,42QYB@68525|delta/epsilon subdivisions,2YNY3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0246 family - - - ko:K09861 - - - - ko00000 - - - H2O2_YaaD k59_16405_1 187272.Mlg_0693 1.43e-100 307.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales 135613|Chromatiales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_16405_2 1304275.C41B8_16374 3.99e-63 207.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO k59_349634_1 177437.HRM2_21090 5.74e-83 263.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42NW5@68525|delta/epsilon subdivisions,2WMJF@28221|Deltaproteobacteria,2MMQW@213118|Desulfobacterales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_314678_1 1168034.FH5T_17635 1.86e-68 213.0 COG1082@1|root,COG1082@2|Bacteria,4NIWS@976|Bacteroidetes,2FQ58@200643|Bacteroidia 976|Bacteroidetes G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N k59_86676_1 292563.Cyast_1775 4.34e-48 171.0 COG1523@1|root,COG1523@2|Bacteria,1G0PW@1117|Cyanobacteria 1117|Cyanobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_86676_2 82654.Pse7367_3453 5.15e-24 94.4 COG1366@1|root,COG1366@2|Bacteria,1G8B3@1117|Cyanobacteria,1HCRD@1150|Oscillatoriales 1117|Cyanobacteria T transporter antisigma-factor antagonist STAS - - - - - - - - - - - - STAS k59_513243_1 929558.SMGD1_0636 9.25e-117 362.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2YMGZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_478460_1 1286632.P278_21010 7.63e-19 85.9 COG0149@1|root,COG0149@2|Bacteria,4NE2F@976|Bacteroidetes,1HY7Y@117743|Flavobacteriia 976|Bacteroidetes G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_478460_2 1161401.ASJA01000006_gene1869 1.66e-60 206.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria,43WXN@69657|Hyphomonadaceae 28211|Alphaproteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_478460_4 1473546.CH76_05805 4.02e-36 127.0 COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,4HIG2@91061|Bacilli,3IXZ4@400634|Lysinibacillus 91061|Bacilli FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases hit - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_478460_5 403833.Pmob_0338 8.45e-62 222.0 COG0608@1|root,COG0608@2|Bacteria,2GC7T@200918|Thermotogae 200918|Thermotogae L single-stranded-DNA-specific exonuclease RecJ - - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1033856_2 617140.AJZE01000093_gene2446 5.81e-19 86.3 2BIBD@1|root,32CH5@2|Bacteria,1QKR4@1224|Proteobacteria,1TIVH@1236|Gammaproteobacteria,1XZS8@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_16420_1 977880.RALTA_A2545 8.8e-89 272.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1K1TT@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_16420_2 522373.Smlt3329 5.74e-42 154.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1X4XY@135614|Xanthomonadales 135614|Xanthomonadales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_478464_1 1437824.BN940_08461 3.11e-41 152.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,3T36T@506|Alcaligenaceae 28216|Betaproteobacteria T C4-dicarboxylate transport transcriptional regulatory protein DctD dctD GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K10126,ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 M00504 - - ko00000,ko00001,ko00002,ko02022,ko03000 - - - HTH_8,Response_reg,Sigma54_activat k59_249997_1 1415778.JQMM01000001_gene29 2.06e-85 264.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1J4SK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_153320_1 1165841.SULAR_10134 4.64e-39 135.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,42NGT@68525|delta/epsilon subdivisions,2YN0R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_153320_2 387092.NIS_1629 6.4e-10 62.4 COG2956@1|root,COG2956@2|Bacteria,1PDTB@1224|Proteobacteria,42PNY@68525|delta/epsilon subdivisions,2YN3M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the low molecular weight phosphotyrosine protein phosphatase family ciaB - - - - - - - - - - - - k59_52087_3 547144.HydHO_1391 1.27e-23 110.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - 2.7.7.65 ko:K21022 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF k59_1033859_1 1122604.JONR01000019_gene1192 6.17e-74 235.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1X2YM@135614|Xanthomonadales 135614|Xanthomonadales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_937171_1 1307759.JOMJ01000003_gene1292 5.78e-102 310.0 COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,42N2K@68525|delta/epsilon subdivisions,2WJ5D@28221|Deltaproteobacteria,2M8TA@213115|Desulfovibrionales 28221|Deltaproteobacteria S FAD dependent oxidoreductase - - - ko:K07137 - - - - ko00000 - - - DAO,FAD_binding_2,GIDA,HI0933_like,Pyr_redox_2 k59_513266_1 555779.Dthio_PD0022 1.54e-90 285.0 COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66 k59_349660_1 1249627.D779_0825 2.11e-66 205.0 COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,1WYCE@135613|Chromatiales 135613|Chromatiales H PFAM molybdopterin biosynthesis MoaE - - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_513715_1 926569.ANT_06620 5.66e-27 109.0 COG0596@1|root,COG0596@2|Bacteria,2G8RI@200795|Chloroflexi 200795|Chloroflexi S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_120289_1 1196322.A370_02699 1.31e-116 340.0 COG3257@1|root,COG3257@2|Bacteria,1TPT2@1239|Firmicutes,247MR@186801|Clostridia,36EG7@31979|Clostridiaceae 186801|Clostridia S protein, possibly involved in glyoxylate - - 3.5.3.26 ko:K14977 ko00230,ko01120,map00230,map01120 - R05554 RC01419 ko00000,ko00001,ko01000 - - - Cupin_2 k59_838949_1 365046.Rta_19980 2.08e-66 213.0 COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,2VSCY@28216|Betaproteobacteria,4AEWX@80864|Comamonadaceae 28216|Betaproteobacteria I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_773486_1 96561.Dole_0560 4.03e-26 111.0 COG0451@1|root,COG1146@1|root,COG0451@2|Bacteria,COG1146@2|Bacteria,1N8PG@1224|Proteobacteria,42UM2@68525|delta/epsilon subdivisions,2WR61@28221|Deltaproteobacteria,2MMN8@213118|Desulfobacterales 28221|Deltaproteobacteria CGM PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,Fer4 k59_52571_1 478741.JAFS01000001_gene1603 8.53e-49 171.0 COG0033@1|root,COG0033@2|Bacteria 2|Bacteria G Phosphoglucomutase pgm GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_52571_2 709032.Sulku_1180 2.31e-24 99.4 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2YMUH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - iIT341.HP1346 Gp_dh_C,Gp_dh_N k59_802844_1 572477.Alvin_2182 9.86e-37 139.0 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales 135613|Chromatiales O TIGRFAM Cytochrome c-type biogenesis protein CcmI - - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_186329_1 1278309.KB907099_gene2542 1.6e-10 66.6 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,1XHGX@135619|Oceanospirillales 135619|Oceanospirillales V protein conserved in bacteria - - - ko:K09760 - - - - ko00000 - - - RmuC k59_1041435_1 1121396.KB892917_gene103 3.4e-28 118.0 COG2268@1|root,COG2268@2|Bacteria,1P50K@1224|Proteobacteria,42PJG@68525|delta/epsilon subdivisions,2WQ9J@28221|Deltaproteobacteria,2MMDR@213118|Desulfobacterales 28221|Deltaproteobacteria S Flotillin - - - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot k59_714829_2 1454004.AW11_02489 1.31e-103 308.0 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,2VTJU@28216|Betaproteobacteria 28216|Betaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_649929_1 945543.VIBR0546_16351 1.19e-77 245.0 COG2327@1|root,COG2327@2|Bacteria 2|Bacteria S slime layer polysaccharide biosynthetic process wgaD - - - - - - - - - - - PS_pyruv_trans k59_225408_1 1249480.B649_10350 2.12e-166 477.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2YN1U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_1041443_1 387092.NIS_0198 2.36e-14 75.1 COG0665@1|root,COG0665@2|Bacteria,1QV9J@1224|Proteobacteria,42PP0@68525|delta/epsilon subdivisions,2YNBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_1041443_3 1168289.AJKI01000001_gene3621 6.78e-21 89.4 COG0384@1|root,COG0384@2|Bacteria,4NEWM@976|Bacteroidetes,2FSSJ@200643|Bacteroidia,3XJYQ@558415|Marinilabiliaceae 976|Bacteroidetes S Phenazine biosynthesis-like protein - - - - - - - - - - - - PhzC-PhzF k59_844977_1 1537994.JQFW01000006_gene2972 1.37e-12 67.4 COG1024@1|root,COG1024@2|Bacteria,1Q67Q@1224|Proteobacteria,1S1Z5@1236|Gammaproteobacteria,466W9@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1024 Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_193216_1 795666.MW7_2550 3.44e-93 278.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,1K1Y9@119060|Burkholderiaceae 28216|Betaproteobacteria E abc transporter livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_321532_1 929558.SMGD1_0321 9.41e-131 409.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2YMRQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_944791_1 1218084.BBJK01000149_gene7525 2.39e-108 324.0 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WB1W@28216|Betaproteobacteria,1K4YH@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_1042114_1 471855.Shel_27820 2.31e-62 206.0 COG0635@1|root,COG0635@2|Bacteria,2GJ2W@201174|Actinobacteria,4CVEC@84998|Coriobacteriia 84998|Coriobacteriia H Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_127217_1 331113.SNE_A07310 2.09e-18 90.1 COG2317@1|root,COG2317@2|Bacteria,2JFNU@204428|Chlamydiae 204428|Chlamydiae E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 k59_127217_2 323850.Shew_1852 2.91e-36 139.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2QA13@267890|Shewanellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrF - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_226084_1 1499967.BAYZ01000181_gene4505 9.51e-17 79.7 COG4585@1|root,COG5002@1|root,COG4585@2|Bacteria,COG5002@2|Bacteria,2NPMD@2323|unclassified Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07675 ko02020,map02020 M00473 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GGDEF,HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg k59_226084_2 1499967.BAYZ01000181_gene4505 1.84e-115 353.0 COG4585@1|root,COG5002@1|root,COG4585@2|Bacteria,COG5002@2|Bacteria,2NPMD@2323|unclassified Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07675 ko02020,map02020 M00473 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GGDEF,HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg k59_226084_3 1499967.BAYZ01000181_gene4504 4.51e-42 147.0 COG3221@1|root,COG3221@2|Bacteria,2NRNS@2323|unclassified Bacteria 2|Bacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_420372_1 387092.NIS_1238 1e-26 103.0 COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,42TC2@68525|delta/epsilon subdivisions,2YPKS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterised protein family (UPF0227) - - - ko:K07000 - - - - ko00000 - - - UPF0227 k59_420372_2 944547.ABLL_2141 5.87e-48 156.0 COG0789@1|root,COG0789@2|Bacteria,1Q3QJ@1224|Proteobacteria,42XN5@68525|delta/epsilon subdivisions,2YR08@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K MerR HTH family regulatory protein - - - - - - - - - - - - MerR_1 k59_485448_1 380394.Lferr_2797 5.25e-19 86.7 COG5433@1|root,COG5433@2|Bacteria,1RAHU@1224|Proteobacteria,1S1TZ@1236|Gammaproteobacteria,2NDWK@225057|Acidithiobacillales 1236|Gammaproteobacteria L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338 k59_226097_1 584708.Apau_2154 5.38e-24 106.0 COG0642@1|root,COG3614@1|root,COG5002@1|root,COG0642@2|Bacteria,COG3614@2|Bacteria,COG5002@2|Bacteria,3T9SP@508458|Synergistetes 508458|Synergistetes T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg,SBP_bac_3 k59_193787_2 1319815.HMPREF0202_00748 1.52e-115 342.0 COG0324@1|root,COG0324@2|Bacteria,378AW@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_193787_3 1408439.JHXW01000008_gene321 8.34e-12 63.5 2E7IM@1|root,3320X@2|Bacteria,37AX6@32066|Fusobacteria 32066|Fusobacteria S zinc-ribbon family - - - - - - - - - - - - zinc_ribbon_15 k59_1042131_1 998088.B565_1881 5.98e-53 176.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1Y3PC@135624|Aeromonadales 135624|Aeromonadales F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_976727_1 572544.Ilyop_2899 6.93e-191 538.0 COG3177@1|root,COG3177@2|Bacteria 2|Bacteria D Filamentation induced by cAMP protein fic XK27_00240 - - - - - - - - - - - Fic,HTH_DeoR k59_944813_1 713586.KB900536_gene1598 3.41e-39 145.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1WWCF@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_226102_1 643867.Ftrac_2856 1.98e-109 328.0 COG0346@1|root,COG0346@2|Bacteria,4NDVG@976|Bacteroidetes,47MTQ@768503|Cytophagia 976|Bacteroidetes E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase,Glyoxalase_4 k59_976730_1 1168034.FH5T_04715 2.46e-64 213.0 COG0323@1|root,COG0323@2|Bacteria,4NDWJ@976|Bacteroidetes,2FMIK@200643|Bacteroidia 976|Bacteroidetes L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_485455_1 991905.SL003B_3823 2.79e-45 151.0 COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2TRTM@28211|Alphaproteobacteria,4BP6E@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family ycgM GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0008948,GO:0016787,GO:0016822,GO:0016823,GO:0016829,GO:0016830,GO:0016831,GO:0018773,GO:0031974,GO:0031981,GO:0034545,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0070013 3.7.1.20 ko:K16165 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R01085 RC00326,RC00446 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_485455_2 744985.HIMB59_00005220 4.75e-40 139.0 COG0600@1|root,COG0600@2|Bacteria,1NJ59@1224|Proteobacteria,2TUZ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system permease component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_226104_1 1122970.AUHC01000004_gene2121 2.12e-18 88.6 COG3577@1|root,COG3577@2|Bacteria,1MYAD@1224|Proteobacteria,2U8U8@28211|Alphaproteobacteria,2KCU8@204457|Sphingomonadales 204457|Sphingomonadales S gag-polyprotein putative aspartyl protease - - - - - - - - - - - - Asp_protease_2 k59_161684_1 83406.HDN1F_29010 7.98e-137 429.0 COG0433@1|root,COG0433@2|Bacteria,1NAXG@1224|Proteobacteria,1SJQR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 3'(2'),5'-bisphosphate nucleotidase activity - - - - - - - - - - - - Inovirus_Gp2 k59_911252_1 1384056.N787_11365 2.54e-85 269.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XA4X@135614|Xanthomonadales 135614|Xanthomonadales V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_878224_1 1117647.M5M_06810 3.73e-26 109.0 COG3291@1|root,COG3291@2|Bacteria,1QU15@1224|Proteobacteria,1T1KN@1236|Gammaproteobacteria,1J4QR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pkd domain containing protein - - - - - - - - - - - - - k59_650432_1 944480.ATUV01000001_gene492 1.48e-58 193.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2M6C9@213113|Desulfurellales 28221|Deltaproteobacteria O Elongator protein 3, MiaB family, Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_521129_1 1492737.FEM08_33460 6.3e-14 76.6 COG3291@1|root,COG5184@1|root,COG3291@2|Bacteria,COG5184@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia,2NSSE@237|Flavobacterium 976|Bacteroidetes O gliding motility-associated C-terminal domain - - - - - - - - - - - - CHU_C,HYR,PKD,SprB,fn3 k59_1009748_1 446466.Cfla_1071 3.4e-88 268.0 COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4F0M2@85016|Cellulomonadaceae 201174|Actinobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_288979_1 929558.SMGD1_0922 3.21e-95 285.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2YMV8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10 ko:K00795 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364 R01658,R02003 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_845577_1 933262.AXAM01000053_gene2714 1.56e-72 230.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2MHZ2@213118|Desulfobacterales 28221|Deltaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2261 ATP-grasp_2,Ligase_CoA k59_356983_1 596323.HMPREF0554_0228 1.14e-08 56.2 COG1464@1|root,COG1464@2|Bacteria,378UA@32066|Fusobacteria 32066|Fusobacteria P Belongs to the nlpA lipoprotein family - - - ko:K02073 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - Lipoprotein_9 k59_356983_2 760011.Spico_0226 3.45e-81 248.0 COG2011@1|root,COG2011@2|Bacteria,2J67S@203691|Spirochaetes 203691|Spirochaetes P D-methionine transport system permease protein MetI - - - ko:K02072 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - BPD_transp_1 k59_356983_3 1120985.AUMI01000017_gene2674 1.16e-12 68.9 COG1135@1|root,COG1135@2|Bacteria,1TPPN@1239|Firmicutes,4H23H@909932|Negativicutes 909932|Negativicutes P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system metN - - ko:K02071 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - ABC_tran,NIL k59_226125_1 709032.Sulku_0037 2.72e-89 280.0 COG1293@1|root,COG1293@2|Bacteria,1R54S@1224|Proteobacteria,42MYG@68525|delta/epsilon subdivisions,2YT8X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K RNA-binding protein homologous to eukaryotic snRNP - - - - - - - - - - - - DUF814,FbpA k59_94245_1 572544.Ilyop_0472 8.51e-123 361.0 COG2508@1|root,COG2508@2|Bacteria 2|Bacteria QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30,PucR k59_911266_1 1380355.JNIJ01000034_gene4322 4.44e-41 154.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,3JTZ5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family MA20_07375 - - - - - - - - - - - Na_H_Exchanger,TrkA_N k59_1042167_1 1283300.ATXB01000001_gene501 5.5e-14 76.6 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XE3A@135618|Methylococcales 135618|Methylococcales C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_454557_1 1150621.SMUL_0150 3.68e-86 269.0 COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1NTJT@1224|Proteobacteria,42NK8@68525|delta/epsilon subdivisions,2YNNU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM Cytochrome c, class I - - - - - - - - - - - - Cyt_bd_oxida_I,Cytochrome_CBB3 k59_454557_2 525898.Sdel_0542 1.33e-59 196.0 COG1271@1|root,COG1271@2|Bacteria,1R5SQ@1224|Proteobacteria,42PZD@68525|delta/epsilon subdivisions,2YNU2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C oxidase subunit - - - - - - - - - - - - - k59_845590_2 765912.Thimo_1634 5.36e-25 98.6 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1WY27@135613|Chromatiales 135613|Chromatiales I PFAM CDP-alcohol phosphatidyltransferase - - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_976779_1 1537917.JU82_04900 2.9e-37 139.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2YMRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_288989_1 1122603.ATVI01000008_gene2317 5.04e-42 156.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X41A@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_715410_1 396588.Tgr7_0941 3.41e-130 395.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1042174_1 765911.Thivi_3184 6.96e-23 93.6 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1WW5Q@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_1042174_2 765910.MARPU_10720 3.27e-70 222.0 COG4659@1|root,COG4659@2|Bacteria,1R6FE@1224|Proteobacteria,1RYZ7@1236|Gammaproteobacteria,1WXWE@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_454571_1 1123256.KB907927_gene1762 6.24e-11 68.6 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1X7AW@135614|Xanthomonadales 135614|Xanthomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_8 k59_521149_1 720554.Clocl_1564 2.01e-44 165.0 COG2730@1|root,COG3291@1|root,COG2730@2|Bacteria,COG3291@2|Bacteria,1TQHH@1239|Firmicutes,24BQU@186801|Clostridia,3WHQE@541000|Ruminococcaceae 186801|Clostridia G Glycoside hydrolase family 44 celA2 - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Dockerin_1,Glyco_hydro_44,PKD k59_24143_1 452637.Oter_3164 1.39e-57 199.0 COG1033@1|root,COG1033@2|Bacteria 2|Bacteria S growth of symbiont in host cell - - - ko:K07003 - - - - ko00000 - - - MMPL k59_390001_1 1052684.PPM_3217 4.6e-106 345.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_845620_1 314278.NB231_13186 8.2e-14 67.8 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZ69@135613|Chromatiales 135613|Chromatiales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_746555_1 1121439.dsat_0638 1.95e-39 139.0 COG0437@1|root,COG0437@2|Bacteria,1RCHX@1224|Proteobacteria,42S80@68525|delta/epsilon subdivisions,2X5D4@28221|Deltaproteobacteria,2MEPC@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding - - - - - - - - - - - - Fer4_11 k59_521158_1 349124.Hhal_2055 1.08e-101 306.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1WW22@135613|Chromatiales 135613|Chromatiales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_24155_1 1382304.JNIL01000001_gene827 2.78e-71 228.0 COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,278SD@186823|Alicyclobacillaceae 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_420454_1 999541.bgla_1g28380 2.27e-60 194.0 COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VQGX@28216|Betaproteobacteria,1JZP8@119060|Burkholderiaceae 28216|Betaproteobacteria S Pfam Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_420454_2 768066.HELO_1902 7.31e-27 109.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1XHZD@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the glutamine synthetase family - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_321608_1 1165841.SULAR_06573 5.08e-65 206.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2YNZK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_781062_1 1168034.FH5T_07290 6.14e-129 377.0 COG1262@1|root,COG1262@2|Bacteria,4NGY2@976|Bacteroidetes,2FPTN@200643|Bacteroidia 976|Bacteroidetes M gliding motility-associated lipoprotein GldK gldK - - - - - - - - - - - FGE-sulfatase k59_94290_1 331869.BAL199_16483 6.71e-64 201.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,4BRCY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter cysA - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_585477_1 321332.CYB_2158 1.02e-48 176.0 COG3280@1|root,COG3280@2|Bacteria,1G3IR@1117|Cyanobacteria,1H00I@1129|Synechococcus 1117|Cyanobacteria G Alpha amylase, catalytic domain treY - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase k59_618429_1 700598.Niako_2950 1.4e-38 148.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - Guanylate_cyc,HTH_18,TPR_16,TPR_2,TPR_8 k59_357026_1 720554.Clocl_1792 2.11e-13 78.2 2ECEX@1|root,336D4@2|Bacteria,1VIN1@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_976826_1 326298.Suden_1882 2.74e-92 285.0 COG3203@1|root,COG3203@2|Bacteria,1QZ2N@1224|Proteobacteria,42QVI@68525|delta/epsilon subdivisions,2YP28@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_1042199_1 395493.BegalDRAFT_1699 7.3e-111 337.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,461Y7@72273|Thiotrichales 72273|Thiotrichales I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_390020_1 1123401.JHYQ01000003_gene2122 4.66e-83 265.0 COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,1SN0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_193873_1 768671.ThimaDRAFT_4484 2.43e-114 337.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales 135613|Chromatiales L PFAM Integrase core domain - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_33 k59_976832_1 439235.Dalk_0297 1.22e-59 207.0 COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHWA@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - ABC_sub_bind,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_357033_1 1528106.JRJE01000020_gene2399 2.69e-64 211.0 COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2TTMX@28211|Alphaproteobacteria,2JR91@204441|Rhodospirillales 204441|Rhodospirillales G Bacterial extracellular solute-binding protein - - - ko:K05813 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - SBP_bac_8 k59_24171_1 187272.Mlg_1338 3.16e-15 76.3 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1009811_1 864702.OsccyDRAFT_4322 1.63e-94 285.0 COG3385@1|root,COG3385@2|Bacteria,1G7HA@1117|Cyanobacteria,1HHM3@1150|Oscillatoriales 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_1009815_1 1232437.KL662073_gene1729 1.35e-75 233.0 COG1024@1|root,COG1024@2|Bacteria,1R61Y@1224|Proteobacteria,42P4M@68525|delta/epsilon subdivisions,2WJJU@28221|Deltaproteobacteria,2MIKD@213118|Desulfobacterales 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_845657_1 397288.C806_00096 6.37e-33 119.0 2C6KN@1|root,32Y69@2|Bacteria,1VANX@1239|Firmicutes,24MNG@186801|Clostridia,27RN3@186928|unclassified Lachnospiraceae 186801|Clostridia S VRR_NUC - - - - - - - - - - - - VRR_NUC k59_845657_3 630626.EBL_c21990 7.92e-13 76.6 2DBGR@1|root,2Z95I@2|Bacteria,1RGBI@1224|Proteobacteria,1T4W7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriophage replication protein O - - - - - - - - - - - - Phage_rep_O k59_845657_4 386415.NT01CX_2201 6.38e-06 47.4 COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24M8M@186801|Clostridia,36JS0@31979|Clostridiaceae 186801|Clostridia K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3 k59_845657_5 1033737.CAEV01000098_gene1754 0.000415 44.3 COG1813@1|root,COG1813@2|Bacteria,1V7HU@1239|Firmicutes,24BDX@186801|Clostridia,36EZN@31979|Clostridiaceae 186801|Clostridia K Helix-turn-helix domain protein - - - - - - - - - - - - HTH_19,HTH_3,HTH_31 k59_884181_1 84531.JMTZ01000032_gene297 9.02e-67 211.0 COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,1RS3G@1236|Gammaproteobacteria,1XCSQ@135614|Xanthomonadales 135614|Xanthomonadales IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.206 ko:K08081 ko00960,ko01100,ko01110,map00960,map01100,map01110 - R02832 RC00144 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_917093_1 1411123.JQNH01000001_gene3232 1.36e-41 148.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2TR14@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_949697_1 686340.Metal_0749 8.78e-51 169.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XE78@135618|Methylococcales 135618|Methylococcales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_34246_1 1537917.JU82_02865 2.22e-38 147.0 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,42PHJ@68525|delta/epsilon subdivisions,2YNKV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_917096_2 948106.AWZT01000036_gene1737 1.46e-19 85.1 COG2146@1|root,COG2146@2|Bacteria,1PTAZ@1224|Proteobacteria,2WDC6@28216|Betaproteobacteria,1K9ZG@119060|Burkholderiaceae 28216|Betaproteobacteria P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_917096_3 1123517.JOMR01000001_gene1483 2.06e-26 109.0 COG0524@1|root,COG2146@1|root,COG0524@2|Bacteria,COG2146@2|Bacteria,1MWX4@1224|Proteobacteria,1RQW6@1236|Gammaproteobacteria,460KJ@72273|Thiotrichales 72273|Thiotrichales G PFAM pfkB family carbohydrate kinase - - 2.7.1.3 ko:K00846 ko00051,ko01100,ko01120,map00051,map01100,map01120 - R00866,R03819 RC00002,RC00017,RC00608 ko00000,ko00001,ko01000,ko04147 - - - PfkB,Rieske k59_720868_1 593117.TGAM_1855 1.03e-09 64.3 COG0531@1|root,COG0589@1|root,arCOG00009@2157|Archaea,arCOG00449@2157|Archaea,2XTX6@28890|Euryarchaeota,24509@183968|Thermococci 183968|Thermococci ET Amino acid permease - - - - - - - - - - - - AA_permease_2,Usp k59_295854_1 1168034.FH5T_16780 6.31e-125 371.0 COG1109@1|root,COG1109@2|Bacteria,4NFU7@976|Bacteroidetes,2FM0A@200643|Bacteroidia 976|Bacteroidetes G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II pgcA - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_917097_1 1168034.FH5T_12205 2.81e-225 644.0 COG0542@1|root,COG0542@2|Bacteria,4NGEM@976|Bacteroidetes,2FM5N@200643|Bacteroidia 976|Bacteroidetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_492027_1 1150626.PHAMO_290001 6.34e-27 103.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2UFTM@28211|Alphaproteobacteria,2JTGW@204441|Rhodospirillales 204441|Rhodospirillales L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_492027_2 909943.HIMB100_00020000 5.03e-16 77.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,4BPPA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_66918_1 870187.Thini_2562 2.47e-85 271.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,45ZRU@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_361430_2 1287488.HMPREF0671_09180 3.15e-21 94.7 COG3307@1|root,COG3307@2|Bacteria,4NF1G@976|Bacteroidetes,2FMHQ@200643|Bacteroidia 976|Bacteroidetes M COG NOG08640 non supervised orthologous group - - - - - - - - - - - - ATPgrasp_TupA k59_426513_1 269797.Mbar_A1769 6.54e-43 159.0 COG1122@1|root,arCOG00188@2157|Archaea,2XV36@28890|Euryarchaeota 28890|Euryarchaeota P ABC transporter - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k59_1014980_1 879212.DespoDRAFT_00836 3.26e-13 64.3 2EJAZ@1|root,3356X@2|Bacteria,1NFZK@1224|Proteobacteria,42V0Q@68525|delta/epsilon subdivisions,2WS7N@28221|Deltaproteobacteria,2MMC0@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1014980_2 1121405.dsmv_1703 2.71e-17 81.6 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MIIB@213118|Desulfobacterales 28221|Deltaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_459477_1 63737.Npun_F1315 5.24e-32 124.0 COG0128@1|root,COG0128@2|Bacteria,1G1F9@1117|Cyanobacteria,1HJP4@1161|Nostocales 1117|Cyanobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_361433_1 1121405.dsmv_0069 1.02e-25 101.0 COG2203@1|root,COG2203@2|Bacteria,1R6PX@1224|Proteobacteria,42NG9@68525|delta/epsilon subdivisions,2WKCE@28221|Deltaproteobacteria,2MING@213118|Desulfobacterales 28221|Deltaproteobacteria T ANTAR - - - - - - - - - - - - ANTAR,GAF_2 k59_99757_1 749222.Nitsa_0964 2.31e-25 108.0 28IG7@1|root,2Z8HR@2|Bacteria,1RM35@1224|Proteobacteria,42RCC@68525|delta/epsilon subdivisions,2YP1C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S YfdX protein - - - - - - - - - - - - YfdX k59_557594_1 870187.Thini_1202 8.77e-50 169.0 COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,1S3T8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ribonuclease BN - - - - - - - - - - - - Virul_fac_BrkB k59_262933_1 1121012.AUKX01000064_gene1065 7.17e-77 245.0 COG5421@1|root,COG5421@2|Bacteria,4PAGJ@976|Bacteroidetes,1IAIH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DDE_Tnp_1 k59_622768_1 1156935.QWE_13483 1.38e-51 177.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,4B8X9@82115|Rhizobiaceae 28211|Alphaproteobacteria P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_622768_2 1294143.H681_09390 4.61e-06 48.1 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_786181_1 1340493.JNIF01000004_gene1116 2.31e-20 86.3 2E7HP@1|root,33206@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1475) - - - - - - - - - - - - DUF1475 k59_132501_1 1304883.KI912532_gene930 3.06e-42 147.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,2KVA0@206389|Rhodocyclales 206389|Rhodocyclales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_132501_2 1163408.UU9_13658 2.31e-39 132.0 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1X7KC@135614|Xanthomonadales 135614|Xanthomonadales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_132501_3 283942.IL2623 2.51e-21 88.6 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,2QG3X@267893|Idiomarinaceae 1236|Gammaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664 ATP-synt_B k59_361444_1 472759.Nhal_2468 1.51e-59 197.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1WVYA@135613|Chromatiales 135613|Chromatiales H TIGRFAM molybdenum cofactor synthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_361444_2 998674.ATTE01000001_gene4334 1.33e-06 48.9 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,460F6@72273|Thiotrichales 72273|Thiotrichales H May be involved in the biosynthesis of molybdopterin - - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_165342_1 572544.Ilyop_0339 9.79e-204 575.0 COG0165@1|root,COG0165@2|Bacteria,378W4@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_688217_1 1035193.HMPREF9073_01185 3.97e-35 124.0 COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1I44D@117743|Flavobacteriia,1ES7J@1016|Capnocytophaga 976|Bacteroidetes M 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_524782_2 357804.Ping_1217 2.43e-234 666.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,2QJ0E@267894|Psychromonadaceae 1236|Gammaproteobacteria C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region hoxF - 1.12.1.2 ko:K18005 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S k59_394011_1 929558.SMGD1_1281 1.27e-157 459.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2YMJR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaGprimase_HBD,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_132512_1 316067.Geob_0157 6.98e-33 124.0 COG1893@1|root,COG1893@2|Bacteria,1R96Z@1224|Proteobacteria,42PU0@68525|delta/epsilon subdivisions,2WK47@28221|Deltaproteobacteria,43SYC@69541|Desulfuromonadales 28221|Deltaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_524784_1 1165841.SULAR_03742 2.88e-37 144.0 COG3387@1|root,COG3387@2|Bacteria,1MXWR@1224|Proteobacteria 1224|Proteobacteria G phosphorylase kinase alphabeta ygeQ - - ko:K07190 ko04020,ko04910,ko04922,map04020,map04910,map04922 - - - ko00000,ko00001 - - - Glyco_hydro_15 k59_655663_1 768671.ThimaDRAFT_1370 6.29e-53 177.0 COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,1RSDK@1236|Gammaproteobacteria,1WVUU@135613|Chromatiales 135613|Chromatiales O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_655663_2 1403313.AXBR01000003_gene4034 1.88e-10 60.5 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,1ZEFV@1386|Bacillus 91061|Bacilli O Subtilase family - - 3.4.21.66 ko:K08651 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_66948_1 1165841.SULAR_09119 1.1e-121 367.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2YM83@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_459498_1 929556.Solca_3185 1.09e-143 418.0 COG3464@1|root,COG3464@2|Bacteria,4NFK7@976|Bacteroidetes,1INXR@117747|Sphingobacteriia 976|Bacteroidetes L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_ISL3 k59_459498_2 153721.MYP_2374 1.23e-38 133.0 COG3464@1|root,COG3464@2|Bacteria,4NSCN@976|Bacteroidetes,47SIZ@768503|Cytophagia 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_328748_2 563040.Saut_2119 1.45e-27 113.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2YMFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_99777_1 1232437.KL662006_gene4362 7.28e-96 303.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI4B@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_688223_1 1121377.KB906402_gene3232 8.1e-58 205.0 COG0457@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3899@2|Bacteria 2|Bacteria T PFAM Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,Trans_reg_C k59_459499_1 1165841.SULAR_08382 9.31e-97 302.0 COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2YMJN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,RMMBL k59_1015004_1 386415.NT01CX_0875 2.34e-28 113.0 COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,36EMZ@31979|Clostridiaceae 186801|Clostridia J Specifically methylates the N7 position of a guanine in 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_426536_1 913865.DOT_4311 3.01e-120 360.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia 186801|Clostridia S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_426536_2 313596.RB2501_12272 1.45e-11 65.1 COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,1HY1D@117743|Flavobacteriia 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_34548_1 1380390.JIAT01000009_gene1420 1.15e-15 80.9 COG1063@1|root,COG1063@2|Bacteria 2|Bacteria E alcohol dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_296367_1 387093.SUN_0239 2.01e-64 204.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2YMGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_296367_2 28072.Nos7524_2393 6.19e-07 55.1 COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,1HMNK@1161|Nostocales 1117|Cyanobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 ko:K00128,ko:K00135,ko:K22187 ko00010,ko00040,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00027,M00135 R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_884552_3 208960.XP_007263647.1 4.83e-11 66.6 COG2940@1|root,KOG1079@2759|Eukaryota,38DMC@33154|Opisthokonta,3NZVU@4751|Fungi,3VBIX@5204|Basidiomycota,22ASF@155619|Agaricomycetes,3H6AZ@355688|Agaricomycetes incertae sedis 4751|Fungi K SET domain-containing protein - - 2.1.1.43 ko:K11430 ko00310,ko05206,map00310,map05206 - R03875,R03938,R04866,R04867 RC00003,RC00060,RC00181,RC00496 ko00000,ko00001,ko01000,ko03036 - - - SET k59_884552_4 393921.HQ45_05495 5.47e-52 171.0 COG0692@1|root,COG0692@2|Bacteria,4NE2B@976|Bacteroidetes,2FM57@200643|Bacteroidia,22WGA@171551|Porphyromonadaceae 976|Bacteroidetes L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_427002_1 2340.JV46_11840 2.05e-79 257.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1J4DP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f k59_819404_1 1168034.FH5T_21195 1.59e-155 458.0 COG1629@1|root,COG1629@2|Bacteria,4NFFN@976|Bacteroidetes,2G3GJ@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug k59_329321_1 639030.JHVA01000001_gene2690 4.47e-24 95.9 COG1846@1|root,COG1846@2|Bacteria,3Y82F@57723|Acidobacteria,2JN6R@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator - - - ko:K15973 - - - - ko00000,ko03000 - - - MarR,MarR_2 k59_329323_1 1232437.KL662002_gene4686 5.13e-12 68.6 COG4966@1|root,COG4966@2|Bacteria,1Q8WF@1224|Proteobacteria,4342J@68525|delta/epsilon subdivisions,2X4VM@28221|Deltaproteobacteria,2MM37@213118|Desulfobacterales 28221|Deltaproteobacteria NU pilus assembly protein PilW - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_263483_1 1276221.SDIMI_v3c04860 1.65e-63 199.0 COG0602@1|root,COG0602@2|Bacteria,3WU1F@544448|Tenericutes 544448|Tenericutes O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine nrdG - 1.97.1.4 ko:K04068 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_296376_1 1165841.SULAR_00560 2.52e-80 253.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,42N4K@68525|delta/epsilon subdivisions,2YMVY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S HI0933 family - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_656301_1 1165841.SULAR_00600 7.08e-92 277.0 28NXH@1|root,2ZBV3@2|Bacteria,1RDDP@1224|Proteobacteria,42ZNQ@68525|delta/epsilon subdivisions,2YRRT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_688753_1 448385.sce4763 2.37e-47 171.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2X37C@28221|Deltaproteobacteria,2YUQZ@29|Myxococcales 28221|Deltaproteobacteria S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT k59_982791_1 270374.MELB17_19981 3.59e-57 201.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,464DC@72275|Alteromonadaceae 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_623355_2 349124.Hhal_1750 4.38e-42 153.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales 135613|Chromatiales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_688758_1 981383.AEWH01000063_gene1886 1.11e-30 118.0 COG0119@1|root,COG0119@2|Bacteria,1TQG3@1239|Firmicutes,4HA1U@91061|Bacilli 91061|Bacilli E Hydroxymethylglutaryl-CoA lyase yngG GO:0003674,GO:0003824,GO:0004419,GO:0005488,GO:0016829,GO:0016830,GO:0016833,GO:0043167,GO:0043169,GO:0046872 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_786717_1 29730.Gorai.005G167700.1 9e-101 308.0 COG0085@1|root,KOG0214@2759|Eukaryota,37HVP@33090|Viridiplantae,3G72V@35493|Streptophyta 35493|Streptophyta K rna polymerase rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_786717_2 3702.ATCG00190.1 6.24e-126 387.0 COG0085@1|root,KOG0214@2759|Eukaryota,37HVP@33090|Viridiplantae,3G72V@35493|Streptophyta,3I0YM@3699|Brassicales 35493|Streptophyta K rna polymerase rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_590627_1 525898.Sdel_1551 6.62e-156 442.0 COG5266@1|root,COG5266@2|Bacteria,1PVKN@1224|Proteobacteria,42PYV@68525|delta/epsilon subdivisions,2YN74@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Domain of unknown function (DUF4198) - - - ko:K02009 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18 - - DUF4198 k59_590627_2 944546.ABED_1686 6.84e-42 139.0 2E451@1|root,32Z13@2|Bacteria,1NE2G@1224|Proteobacteria,43BCP@68525|delta/epsilon subdivisions,2YPY8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_590627_3 944547.ABLL_0863 0.0 1167.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2YMB3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB2 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_590627_4 944547.ABLL_0864 2.23e-25 96.3 COG1918@1|root,COG1918@2|Bacteria,1Q63D@1224|Proteobacteria,42W1S@68525|delta/epsilon subdivisions,2YQFR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P FeoA - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_590627_5 273121.WS1424 1.85e-15 75.9 2EU78@1|root,33MPQ@2|Bacteria,1NITN@1224|Proteobacteria,4318A@68525|delta/epsilon subdivisions,2YS8N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_590627_6 525898.Sdel_1561 4.79e-256 729.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42N39@68525|delta/epsilon subdivisions,2YN3G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB dependent receptor - - - ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10 - - Plug,TonB_dep_Rec k59_819420_1 1410674.JNKU01000010_gene1732 2.88e-32 125.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,4H9Y8@91061|Bacilli,3F4MW@33958|Lactobacillaceae 91061|Bacilli L Participates in initiation and elongation during chromosome replication dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_819420_2 693986.MOC_3529 5.96e-29 114.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2TRZM@28211|Alphaproteobacteria,1JQWH@119045|Methylobacteriaceae 28211|Alphaproteobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_819420_3 1089439.KB902274_gene1871 5.21e-28 106.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,460ZR@72273|Thiotrichales 72273|Thiotrichales J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_819420_4 1276756.AUEX01000020_gene3393 1.52e-10 68.6 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,4AATV@80864|Comamonadaceae 28216|Betaproteobacteria S RmuC family rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_525373_1 387093.SUN_1460 7.2e-102 309.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2YN9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_329338_1 1192034.CAP_4227 6.1e-23 96.7 COG0300@1|root,COG0300@2|Bacteria,1PG5S@1224|Proteobacteria,43473@68525|delta/epsilon subdivisions,2X263@28221|Deltaproteobacteria,2YXTC@29|Myxococcales 28221|Deltaproteobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_329338_2 1283287.KB822582_gene2972 8.81e-16 80.9 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DWF4@85009|Propionibacteriales 201174|Actinobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF k59_856467_2 1158345.JNLL01000001_gene1315 2.06e-07 52.4 COG1047@1|root,COG1047@2|Bacteria,2G452@200783|Aquificae 200783|Aquificae O Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_692911_1 396588.Tgr7_0025 1.48e-71 226.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1WXHI@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_627682_2 572544.Ilyop_1552 5.26e-116 344.0 COG0132@1|root,COG1435@1|root,COG0132@2|Bacteria,COG1435@2|Bacteria,378FT@32066|Fusobacteria 32066|Fusobacteria F thymidine kinase tdk - 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK k59_987158_1 563040.Saut_0845 1.85e-91 276.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2YMRK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_627686_1 933262.AXAM01000069_gene2694 3.55e-30 119.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,2MIFD@213118|Desulfobacterales 28221|Deltaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_627686_2 439235.Dalk_1797 8.32e-74 229.0 COG1215@1|root,COG1215@2|Bacteria,1RJNP@1224|Proteobacteria,42ST7@68525|delta/epsilon subdivisions,2X7KP@28221|Deltaproteobacteria,2MPM9@213118|Desulfobacterales 28221|Deltaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_856898_6 2340.JV46_07320 5.27e-59 184.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1J668@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_856898_7 765912.Thimo_2854 1.85e-128 369.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1WVYC@135613|Chromatiales 135613|Chromatiales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_465087_1 1085623.GNIT_0273 2.21e-09 58.9 COG2863@1|root,COG2863@2|Bacteria 2|Bacteria C cytochrome - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_693402_1 1249480.B649_03910 2.33e-13 68.6 COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,42TJ0@68525|delta/epsilon subdivisions,2YPZ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T phosphohistidine phosphatase, SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_725789_1 573370.DMR_39170 5.54e-32 139.0 COG2203@1|root,COG3829@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions,2WPBU@28221|Deltaproteobacteria,2MA5B@213115|Desulfovibrionales 28221|Deltaproteobacteria T Membrane-associated sensor domain - - - - - - - - - - - - GAF_2,HATPase_c,MASE3,NMT1,PAS_4,PAS_9,SBP_bac_3,dCache_1 k59_334479_1 572544.Ilyop_0614 3.54e-88 276.0 COG1164@1|root,COG1164@2|Bacteria,3797Y@32066|Fusobacteria 32066|Fusobacteria E oligoendopeptidase, M3 family - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_954454_1 572544.Ilyop_1350 1.14e-120 369.0 COG1199@1|root,COG1199@2|Bacteria,378GX@32066|Fusobacteria 32066|Fusobacteria L K03722 ATP-dependent DNA helicase DinG - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2 k59_790669_1 526224.Bmur_1882 4.58e-08 57.8 COG1875@1|root,COG1875@2|Bacteria 2|Bacteria T PIN domain phoH - - ko:K07175 - - - - ko00000 - - - AAA_11,AAA_12,PIN_4,PhoH k59_138327_1 1249480.B649_02245 8.01e-92 282.0 COG0618@1|root,COG0618@2|Bacteria,1RADZ@1224|Proteobacteria,43DQA@68525|delta/epsilon subdivisions,2YT8A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DHH family - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_235791_1 1380384.JADN01000006_gene2491 1.65e-95 294.0 COG1115@1|root,COG1115@2|Bacteria,4NDX7@976|Bacteroidetes,1HXM9@117743|Flavobacteriia 976|Bacteroidetes E alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_987641_1 1123261.AXDW01000034_gene2116 1.86e-32 122.0 COG0697@1|root,COG0697@2|Bacteria,1MXX1@1224|Proteobacteria,1RPRZ@1236|Gammaproteobacteria,1X4Y9@135614|Xanthomonadales 135614|Xanthomonadales EG Permeases of the drug metabolite transporter (DMT) superfamily yedA - - - - - - - - - - - EamA k59_431189_1 1232437.KL661971_gene4862 5.03e-38 145.0 29DE2@1|root,300BX@2|Bacteria,1NC7M@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_856915_1 572477.Alvin_0467 1.73e-87 287.0 COG0587@1|root,COG1372@1|root,COG0587@2|Bacteria,COG1372@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_431191_1 56780.SYN_01346 2.04e-25 102.0 COG2214@1|root,COG2214@2|Bacteria,1NW19@1224|Proteobacteria,43012@68525|delta/epsilon subdivisions,2WVBG@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM heat shock protein DnaJ domain protein - - - - - - - - - - - - - k59_465100_1 1172190.M947_02945 1.58e-89 281.0 29W5U@1|root,30HQY@2|Bacteria,1QUJN@1224|Proteobacteria,42NUV@68525|delta/epsilon subdivisions,2YNFP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_628176_1 694427.Palpr_0073 2.3e-129 391.0 COG3507@1|root,COG3507@2|Bacteria,4NEIZ@976|Bacteroidetes,2FMGY@200643|Bacteroidia,2325E@171551|Porphyromonadaceae 976|Bacteroidetes G Glycosyl hydrolases family 32 N-terminal domain - - - - - - - - - - - - Glyco_hydro_43 k59_105601_1 1198232.CYCME_1793 2.65e-17 79.3 COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,1SB0K@1236|Gammaproteobacteria,4630Z@72273|Thiotrichales 72273|Thiotrichales C hydrogenase maturation protease - - - - - - - - - - - - - k59_105601_2 1122218.KB893653_gene1235 6.75e-07 51.6 COG3009@1|root,COG3009@2|Bacteria 2|Bacteria Q Protein conserved in bacteria - - - ko:K09857 - - - - ko00000 - - - ABC_trans_aux k59_497664_1 439235.Dalk_0097 2.17e-26 105.0 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2WMYW@28221|Deltaproteobacteria,2MJGK@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_497664_2 713586.KB900536_gene635 1e-10 62.8 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1WXN2@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) - - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_758308_1 1121405.dsmv_1461 6.76e-102 306.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,42NTX@68525|delta/epsilon subdivisions,2WMFG@28221|Deltaproteobacteria,2MITC@213118|Desulfobacterales 28221|Deltaproteobacteria E FAD dependent oxidoreductase soxB - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD k59_824185_1 1232437.KL661958_gene2869 2.19e-30 124.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MHNT@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_693419_1 76114.p2A163 3.92e-154 443.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,2VRJ7@28216|Betaproteobacteria,2KZUS@206389|Rhodocyclales 206389|Rhodocyclales L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_33 k59_693419_2 1125863.JAFN01000001_gene634 3.74e-47 160.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,42RGI@68525|delta/epsilon subdivisions,2WNGP@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_29,HTH_33 k59_530495_2 270374.MELB17_22545 1.21e-55 189.0 COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_366822_1 572544.Ilyop_1075 9.99e-60 192.0 COG1212@1|root,COG1212@2|Bacteria,378DT@32066|Fusobacteria 32066|Fusobacteria M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_366822_2 572544.Ilyop_1543 4.04e-105 309.0 COG2877@1|root,COG2877@2|Bacteria,3786I@32066|Fusobacteria 32066|Fusobacteria H 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_465107_1 292.DM42_4287 2.52e-95 297.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VIW3@28216|Betaproteobacteria,1K0B5@119060|Burkholderiaceae 28216|Betaproteobacteria C NADH flavin oxidoreductase NADH oxidase fadH - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_203049_1 929558.SMGD1_0871 2.41e-07 52.8 COG0658@1|root,COG0658@2|Bacteria,1PY6P@1224|Proteobacteria,42NU2@68525|delta/epsilon subdivisions,2YME0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Competence protein comE - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence k59_203049_2 563040.Saut_0341 3.95e-71 228.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2YM91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_366826_1 1056820.KB900643_gene852 2.09e-74 231.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RS50@1236|Gammaproteobacteria,2PN3U@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Binding-protein-dependent transport system inner membrane component tauC - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_300549_2 767434.Fraau_2650 3.35e-44 152.0 COG0515@1|root,COG0515@2|Bacteria,1N75K@1224|Proteobacteria,1RZ61@1236|Gammaproteobacteria,1X5C5@135614|Xanthomonadales 135614|Xanthomonadales KLT serine threonine protein kinase - - - - - - - - - - - - APH k59_693427_1 264198.Reut_A1800 2.23e-28 111.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,1K1VT@119060|Burkholderiaceae 28216|Betaproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp,Epimerase k59_693427_2 953739.SVEN_5781 5.39e-27 108.0 COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria 201174|Actinobacteria C F420-dependent oxidoreductase - - 1.14.14.5 ko:K04091 ko00920,map00920 - R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_72539_1 367737.Abu_1717 7.65e-111 343.0 COG0286@1|root,COG0286@2|Bacteria,1MXPV@1224|Proteobacteria,42QFW@68525|delta/epsilon subdivisions,2YND9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Type I restriction enzyme R protein N terminus (HSDR_N) - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HSDR_N_2,N6_Mtase k59_758326_1 1121413.JMKT01000011_gene2386 6.75e-97 297.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria,2M9R3@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_8 k59_661297_1 2340.JV46_18340 1.25e-48 162.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,1J6FA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479 ABC_tran k59_725831_1 745411.B3C1_17462 1.37e-60 204.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RR88@1236|Gammaproteobacteria,1J5WK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - DPPIV_N,PD40,Peptidase_S9 k59_954489_2 326298.Suden_1013 3.04e-31 114.0 COG4378@1|root,COG4378@2|Bacteria,1N83H@1224|Proteobacteria,42SA3@68525|delta/epsilon subdivisions,2YPM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterized protein conserved in bacteria (DUF2325) - - - - - - - - - - - - DUF2325 k59_954489_3 1313421.JHBV01000007_gene4217 2.47e-06 48.5 COG0716@1|root,COG0716@2|Bacteria,4NP3J@976|Bacteroidetes 976|Bacteroidetes C Low-potential electron donor to a number of redox enzymes isiB - - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 k59_530512_1 1121405.dsmv_2525 4.34e-95 295.0 COG3829@1|root,COG3829@2|Bacteria,1N4M6@1224|Proteobacteria,42M38@68525|delta/epsilon subdivisions,2WIR0@28221|Deltaproteobacteria,2MIR7@213118|Desulfobacterales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,PAS_9,Sigma54_activat k59_203058_1 713586.KB900536_gene37 2.08e-74 251.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria 1224|Proteobacteria L double-strand break repair protein AddB addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_987673_1 757424.Hsero_3963 1.69e-24 107.0 COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,472R0@75682|Oxalobacteraceae 28216|Betaproteobacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 k59_334521_1 102129.Lepto7375DRAFT_1712 1.78e-06 56.6 COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,1GHFQ@1117|Cyanobacteria,1HHWS@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_9,Response_reg k59_693444_1 1248916.ANFY01000010_gene383 5.1e-31 114.0 COG3631@1|root,COG3631@2|Bacteria,1N4Y4@1224|Proteobacteria 1224|Proteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_888945_1 44251.PDUR_06935 1.02e-57 181.0 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,4HGXD@91061|Bacilli,26WZE@186822|Paenibacillaceae 91061|Bacilli G Ribose 5-phosphate isomerase lacA - 5.3.1.26,5.3.1.6 ko:K01808,ko:K01819 ko00030,ko00051,ko00052,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R03240,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_888945_2 1121938.AUDY01000003_gene1 1.07e-34 132.0 COG1028@1|root,COG1028@2|Bacteria,1TVGW@1239|Firmicutes,4HAP9@91061|Bacilli,3NEAM@45667|Halobacillus 91061|Bacilli IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_595170_1 1121468.AUBR01000012_gene2601 5.94e-31 112.0 2F0YS@1|root,33U0E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_595170_2 880072.Desac_0497 1.45e-42 139.0 2FJKA@1|root,34B9P@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_595170_4 1121468.AUBR01000012_gene2604 4.93e-37 129.0 2F79F@1|root,33ZQP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_267816_2 163908.KB235896_gene447 1.29e-27 105.0 COG0537@1|root,COG0537@2|Bacteria 2|Bacteria FG bis(5'-adenosyl)-triphosphatase activity - - - - - - - - - - - - HIT k59_888953_2 204669.Acid345_1392 5.25e-37 140.0 COG2804@1|root,COG2804@2|Bacteria,3Y3GB@57723|Acidobacteria,2JHVF@204432|Acidobacteriia 2|Bacteria NU PFAM Type II secretion system protein E pilB - - ko:K02454,ko:K02504,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_138384_1 1168034.FH5T_00395 2.75e-66 221.0 COG0760@1|root,COG0760@2|Bacteria,4NGIR@976|Bacteroidetes,2FNS9@200643|Bacteroidia 976|Bacteroidetes M peptidylprolyl isomerase - - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 k59_38633_3 998088.B565_1889 1.97e-90 271.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,1Y4B9@135624|Aeromonadales 135624|Aeromonadales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_38633_4 1049564.TevJSym_ab02030 5.95e-30 112.0 COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,1S70H@1236|Gammaproteobacteria,1J6ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Invasion gene expression up-regulator, SirB - - - - - - - - - - - - SirB k59_38633_5 1448139.AI20_04230 1e-78 243.0 COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,1RPCX@1236|Gammaproteobacteria,1Y3TI@135624|Aeromonadales 135624|Aeromonadales S Uncharacterised protein family UPF0066 - - - - - - - - - - - - UPF0066 k59_38633_6 716544.wcw_0147 3.03e-69 219.0 COG4221@1|root,COG4221@2|Bacteria,2JG1X@204428|Chlamydiae 204428|Chlamydiae S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_38633_8 572477.Alvin_1417 3.74e-121 349.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_38633_9 1049564.TevJSym_bm00090 1.94e-59 186.0 COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S7F0@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_38633_10 631362.Thi970DRAFT_02308 7.01e-60 189.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WY2N@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_38633_11 1049564.TevJSym_av00450 1.27e-125 367.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1J54Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0032775,GO:0034641,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140096,GO:0140097,GO:1901360,GO:1901564 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_38633_12 1049564.TevJSym_av00440 6.12e-42 140.0 2E5B5@1|root,33039@2|Bacteria,1NDK8@1224|Proteobacteria,1SFKE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_38633_13 1049564.TevJSym_av00430 2.29e-245 684.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1J4CI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 ko:K02495 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R06895 RC00884 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403 HemN_C,Radical_SAM k59_38633_15 1049564.TevJSym_an00490 4.21e-135 388.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1J4DJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_38633_16 765910.MARPU_13685 5.63e-95 286.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1WVWE@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_38633_17 1049564.TevJSym_au00100 1.22e-134 387.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1J5DH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial transferase hexapeptide (six repeats) cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0840 Hexapep,SATase_N k59_38633_18 765913.ThidrDRAFT_2539 5.37e-64 200.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WVXA@135613|Chromatiales 135613|Chromatiales K Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_38633_19 395493.BegalDRAFT_3220 1.28e-237 659.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,4606V@72273|Thiotrichales 72273|Thiotrichales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_38633_20 1195246.AGRI_14350 1.19e-71 217.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,466TH@72275|Alteromonadaceae 1236|Gammaproteobacteria C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters iscU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0036455,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564 - ko:K04488 - - - - ko00000 - - iAPECO1_1312.APECO1_3996,iB21_1397.B21_02385,iBWG_1329.BWG_2293,iE2348C_1286.E2348C_2812,iEC042_1314.EC042_2733,iEC55989_1330.EC55989_2814,iECABU_c1320.ECABU_c28350,iECBD_1354.ECBD_1155,iECB_1328.ECB_02421,iECDH10B_1368.ECDH10B_2696,iECDH1ME8569_1439.ECDH1ME8569_2456,iECD_1391.ECD_02421,iECED1_1282.ECED1_2960,iECH74115_1262.ECH74115_3761,iECIAI1_1343.ECIAI1_2581,iECIAI39_1322.ECIAI39_2730,iECNA114_1301.ECNA114_2608,iECO103_1326.ECO103_3046,iECO111_1330.ECO111_3253,iECO26_1355.ECO26_3576,iECOK1_1307.ECOK1_2878,iECP_1309.ECP_2534,iECS88_1305.ECS88_2705,iECSE_1348.ECSE_2815,iECSF_1327.ECSF_2373,iECSP_1301.ECSP_3473,iECUMN_1333.ECUMN_2849,iECW_1372.ECW_m2755,iECs_1301.ECs3395,iEKO11_1354.EKO11_1204,iETEC_1333.ETEC_2686,iEcDH1_1363.EcDH1_1139,iEcE24377_1341.EcE24377A_2814,iEcHS_1320.EcHS_A2680,iEcSMS35_1347.EcSMS35_2682,iEcolC_1368.EcolC_1148,iG2583_1286.G2583_3059,iJO1366.b2529,iSDY_1059.SDY_2725,iSFV_1184.SFV_2577,iSF_1195.SF2576,iSFxv_1172.SFxv_2832,iSSON_1240.SSON_2611,iS_1188.S2748,iUMN146_1321.UM146_04055,iUMNK88_1353.UMNK88_3182,iUTI89_1310.UTI89_C2851,iWFL_1372.ECW_m2755,iY75_1357.Y75_RS13200,iZ_1308.Z3796,ic_1306.c3055 NifU_N k59_38633_21 2340.JV46_04110 3.87e-56 176.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1J6FZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system iscA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016530,GO:0019538,GO:0022607,GO:0031163,GO:0034986,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:0140104,GO:1901564 - ko:K05997,ko:K13628 - - - - ko00000,ko03016 - - iAPECO1_1312.APECO1_3997,iB21_1397.B21_02384,iBWG_1329.BWG_2292,iE2348C_1286.E2348C_2811,iEC042_1314.EC042_2732,iEC55989_1330.EC55989_2813,iECABU_c1320.ECABU_c28340,iECBD_1354.ECBD_1156,iECB_1328.ECB_02420,iECDH10B_1368.ECDH10B_2695,iECD_1391.ECD_02420,iECED1_1282.ECED1_2959,iECIAI1_1343.ECIAI1_2580,iECIAI39_1322.ECIAI39_2729,iECNA114_1301.ECNA114_2607,iECO103_1326.ECO103_3045,iECO111_1330.ECO111_3252,iECO26_1355.ECO26_3575,iECOK1_1307.ECOK1_2877,iECP_1309.ECP_2533,iECS88_1305.ECS88_2704,iECSE_1348.ECSE_2814,iECSF_1327.ECSF_2372,iECSP_1301.ECSP_3472,iECUMN_1333.ECUMN_2848,iECW_1372.ECW_m2754,iECs_1301.ECs3394,iEKO11_1354.EKO11_1205,iETEC_1333.ETEC_2685,iEcDH1_1363.EcDH1_1140,iEcSMS35_1347.EcSMS35_2681,iEcolC_1368.EcolC_1149,iG2583_1286.G2583_3058,iJO1366.b2528,iLF82_1304.LF82_1120,iNRG857_1313.NRG857_12580,iSBO_1134.SBO_2552,iSDY_1059.SDY_2724,iSF_1195.SF2575,iSSON_1240.SSON_2610,iS_1188.S2747,iUMN146_1321.UM146_04060,iUMNK88_1353.UMNK88_3181,iWFL_1372.ECW_m2754,iY75_1357.Y75_RS13195,iZ_1308.Z3795,ic_1306.c3053 Fe-S_biosyn k59_38633_22 1049564.TevJSym_au00150 3.7e-61 194.0 COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,1S9YH@1236|Gammaproteobacteria,1J6NP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA hscB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04082 - - - - ko00000,ko03029,ko03110 - - - DnaJ,HSCB_C k59_77630_7 506534.Rhein_0357 3.1e-10 66.6 2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,1WZS1@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_77630_8 1049564.TevJSym_as00070 2.14e-180 509.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1J549@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - iSSON_1240.SSON_4131 Semialdhyde_dh,Semialdhyde_dhC k59_77630_10 1026882.MAMP_03127 1.06e-57 182.0 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria,460VS@72273|Thiotrichales 72273|Thiotrichales S PFAM Uncharacterised protein family (UPF0093) - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_77630_11 1408418.JNJH01000003_gene2258 3.87e-121 358.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2TRRT@28211|Alphaproteobacteria,2JPZ6@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferase family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_77630_12 1150469.RSPPHO_01843 6.71e-20 87.0 COG2246@1|root,COG2246@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process yngA - - - - - - - - - - - GtrA k59_77630_13 379066.GAU_3247 2.66e-33 134.0 2B33H@1|root,31VR5@2|Bacteria,1ZUG1@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_77630_14 1123256.KB907931_gene2743 2.57e-55 191.0 COG1262@1|root,COG1262@2|Bacteria,1R59H@1224|Proteobacteria 1224|Proteobacteria S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase k59_77630_16 631362.Thi970DRAFT_04202 3.49e-37 129.0 COG0316@1|root,COG0316@2|Bacteria,1RFIX@1224|Proteobacteria,1S3SB@1236|Gammaproteobacteria,1WYBH@135613|Chromatiales 135613|Chromatiales S Belongs to the HesB IscA family - - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_77630_17 1249627.D779_3256 4.21e-38 134.0 2B7TJ@1|root,32102@2|Bacteria,1RHKS@1224|Proteobacteria,1S7PY@1236|Gammaproteobacteria,1WYNN@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF5063) - - - - - - - - - - - - DUF5063 k59_77630_18 1049564.TevJSym_as00120 1.31e-78 245.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1J67H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_77630_19 2340.JV46_16560 2.06e-67 213.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,1J6HM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_77630_20 1049564.TevJSym_as00140 1.47e-250 694.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_77630_21 768671.ThimaDRAFT_3413 1.13e-310 867.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_305338_1 87626.PTD2_11404 0.000253 41.2 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,2Q2DF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Belongs to the P(II) protein family glnB GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006808,GO:0008144,GO:0008150,GO:0009889,GO:0010565,GO:0017076,GO:0019216,GO:0019217,GO:0019222,GO:0030234,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042304,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046890,GO:0050789,GO:0050790,GO:0050794,GO:0062012,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901363 - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_371965_1 1005048.CFU_0494 6.26e-61 208.0 COG0526@1|root,COG0526@2|Bacteria,1MWU8@1224|Proteobacteria,2VPNK@28216|Betaproteobacteria,475CR@75682|Oxalobacteraceae 28216|Betaproteobacteria M Thioredoxin-like - - - - - - - - - - - - Thioredoxin_2,Thioredoxin_7 k59_240737_1 1049564.TevJSym_aj00280 6.35e-80 246.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1J4D5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_305344_1 387093.SUN_0171 1.02e-95 290.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,42NR8@68525|delta/epsilon subdivisions,2YTM9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Peptidase dimerisation domain - - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_404032_1 87626.PTD2_09642 6.13e-19 85.1 COG3160@1|root,COG3160@2|Bacteria,1RHBB@1224|Proteobacteria,1S420@1236|Gammaproteobacteria,2Q19G@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Belongs to the Rsd AlgQ family rsd GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - ko:K07740 - - - - ko00000 - - - Rsd_AlgQ k59_829223_1 935948.KE386494_gene226 2.64e-07 50.8 COG4109@1|root,COG4109@2|Bacteria,1VA3T@1239|Firmicutes,24MQM@186801|Clostridia,42GIG@68295|Thermoanaerobacterales 186801|Clostridia K DRTGG domain - - - - - - - - - - - - DRTGG k59_730267_1 1168034.FH5T_05585 4.24e-88 286.0 COG0755@1|root,COG0755@2|Bacteria,4NDY1@976|Bacteroidetes,2FKZ1@200643|Bacteroidia 976|Bacteroidetes O cytochrome c-type biogenesis protein CcsB ccsA - - - - - - - - - - - Cytochrom_C_asm,ResB k59_959753_1 572544.Ilyop_1077 2.68e-98 295.0 COG0371@1|root,COG0371@2|Bacteria,378Q3@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score - - 1.1.1.6 ko:K00005 ko00561,ko00640,ko01100,map00561,map00640,map01100 - R01034,R10715,R10717 RC00029,RC00117,RC00670 ko00000,ko00001,ko01000 - - - Fe-ADH k59_928073_1 1304888.ATWF01000002_gene513 1.07e-16 87.0 COG3267@1|root,COG3267@2|Bacteria,2GFHJ@200930|Deferribacteres 200930|Deferribacteres U AAA domain - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,SH3_3 k59_208863_1 999541.bgla_2g27990 3.37e-41 154.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,1K22A@119060|Burkholderiaceae 28216|Betaproteobacteria EQ 5-oxoprolinase - - 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_469771_1 1168034.FH5T_01765 5.38e-53 170.0 COG0454@1|root,COG0456@2|Bacteria,4NTRS@976|Bacteroidetes,2FS7C@200643|Bacteroidia 976|Bacteroidetes K acetyltransferase - - - - - - - - - - - - DinB_2 k59_469771_2 1168034.FH5T_01770 2.59e-62 193.0 2C85M@1|root,31482@2|Bacteria,4PK2B@976|Bacteroidetes,2FZHD@200643|Bacteroidia 976|Bacteroidetes S Stress responsive A/B Barrel Domain - - - - - - - - - - - - Dabb k59_763455_5 706587.Desti_2197 1.04e-24 104.0 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,42WFA@68525|delta/epsilon subdivisions,2X5AZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Pfam:Gp37_Gp68 - - - - - - - - - - - - DUF5131 k59_7716_1 387093.SUN_0001 3.58e-101 305.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2YM88@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_43202_1 1168034.FH5T_17555 6.52e-72 224.0 28HA8@1|root,2Z7MQ@2|Bacteria,4NEJD@976|Bacteroidetes,2FP92@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF4835) - - - - - - - - - - - - DUF4835 k59_240747_1 314345.SPV1_04928 3.71e-83 273.0 28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria 1224|Proteobacteria S phosphoenolpyruvate carboxykinase (diphosphate) activity - - 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 - R00346 RC02741 ko00000,ko00001,ko01000 - - - - k59_240749_2 1283300.ATXB01000001_gene1279 3.28e-12 65.5 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_110539_1 96561.Dole_2404 4.1e-60 197.0 COG2303@1|root,COG2303@2|Bacteria,1QC41@1224|Proteobacteria,43E7D@68525|delta/epsilon subdivisions,2WZX2@28221|Deltaproteobacteria,2MN26@213118|Desulfobacterales 28221|Deltaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_371993_1 1408473.JHXO01000008_gene2772 8.27e-27 109.0 COG0369@1|root,COG1151@2|Bacteria,4NGRB@976|Bacteroidetes,2FMDK@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k59_371993_2 869213.JCM21142_104362 1e-16 79.7 COG0664@1|root,COG0664@2|Bacteria,4NRFI@976|Bacteroidetes 976|Bacteroidetes K Crp-like helix-turn-helix domain - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_305373_2 1499967.BAYZ01000131_gene344 7.19e-17 80.9 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_4 k59_959777_1 1249480.B649_10855 5.82e-20 92.8 COG1426@1|root,COG1426@2|Bacteria,1Q33C@1224|Proteobacteria,42WQB@68525|delta/epsilon subdivisions,2YQFX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_959777_2 326298.Suden_1908 4.19e-15 72.8 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42MZF@68525|delta/epsilon subdivisions,2YMQX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_503591_1 1499967.BAYZ01000078_gene987 2.11e-41 149.0 COG0701@1|root,COG0701@2|Bacteria,2NQ6E@2323|unclassified Bacteria 2|Bacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1,HMA k59_698506_2 768671.ThimaDRAFT_2332 1.52e-14 72.8 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales 135613|Chromatiales H Uroporphyrinogen III synthase - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_666743_1 999411.HMPREF1092_02163 4.3e-08 61.2 COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,25B0K@186801|Clostridia,36WB5@31979|Clostridiaceae 186801|Clostridia S Uncharacterised protein, DegV family COG1307 - - - - - - - - - - - - DegV k59_7733_1 1178537.BA1_16601 7e-11 68.6 COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,4HA8T@91061|Bacilli,1ZBKU@1386|Bacillus 91061|Bacilli K COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_894695_1 945713.IALB_1659 1.9e-18 82.8 COG2391@1|root,COG2391@2|Bacteria 2|Bacteria - - - - - ko:K07112 - - - - ko00000 - - - Rhodanese,Sulf_transp k59_894695_2 945713.IALB_1660 4.26e-32 117.0 COG2391@1|root,COG2391@2|Bacteria 2|Bacteria - - - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_436260_1 387093.SUN_1579 1.91e-69 226.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2YNJR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P potassium channel protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2,TrkA_C,TrkA_N k59_536037_1 1122134.KB893650_gene124 2.21e-80 253.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1XN9R@135619|Oceanospirillales 135619|Oceanospirillales S Serine aminopeptidase, S33 - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1,Abhydrolase_6 k59_536037_2 95619.PM1_0214675 4.92e-112 335.0 COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,1RS16@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Saccharopine dehydrogenase lys - - - - - - - - - - - Sacchrp_dh_NADP k59_110564_1 1120973.AQXL01000121_gene43 2.35e-25 99.8 COG1956@1|root,COG1956@2|Bacteria,1V6GQ@1239|Firmicutes,4HH7X@91061|Bacilli,278MK@186823|Alicyclobacillaceae 91061|Bacilli T GAF domain ytsP - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF_2 k59_110564_2 935567.JAES01000025_gene1241 2.31e-12 67.4 COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,1S2AY@1236|Gammaproteobacteria,1X61S@135614|Xanthomonadales 135614|Xanthomonadales T phosphoglycerate mutase - - - - - - - - - - - - His_Phos_1 k59_829251_1 1052684.PPM_0587 3.1e-41 148.0 COG0179@1|root,COG0179@2|Bacteria,1TXA5@1239|Firmicutes,4I67F@91061|Bacilli,26R3V@186822|Paenibacillaceae 91061|Bacilli Q Fumarylacetoacetate hydrolase mhpD - - - - - - - - - - - FAA_hydrolase k59_993735_2 269799.Gmet_2265 1.58e-10 61.6 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2WK12@28221|Deltaproteobacteria,43TGU@69541|Desulfuromonadales 28221|Deltaproteobacteria C PFAM Electron transfer flavoprotein alpha subunit - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_436706_1 1121937.AUHJ01000026_gene38 6.87e-98 295.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,464M3@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase, Mutator family - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_504159_1 563040.Saut_0105 1.2e-21 91.3 COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2YMNQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_504159_2 1249480.B649_00400 8.42e-40 133.0 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,42VAB@68525|delta/epsilon subdivisions,2YPTR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar biosynthetic protein FliQ fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 k59_372433_1 1249627.D779_0893 3.3e-137 406.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales 135613|Chromatiales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_730753_1 1499967.BAYZ01000123_gene2521 3.5e-12 71.2 COG1649@1|root,COG3023@1|root,COG3291@1|root,COG1649@2|Bacteria,COG3023@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria 2|Bacteria M PKD domain - - 3.2.1.11,3.2.1.18,3.2.1.35,4.2.2.23 ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K18197 ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142 M00076,M00077 R04018,R07824,R07825,R10905,R11309 RC00028,RC00077 ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 - GH33,GH66,PL11 - GHL10,Glyco_hydro_20b,NAGidase,PKD k59_730753_2 385682.AFSL01000089_gene922 8.2e-152 451.0 COG3507@1|root,COG3507@2|Bacteria,4NI92@976|Bacteroidetes,2G2P8@200643|Bacteroidia 976|Bacteroidetes G F5 8 type C domain - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_43,Laminin_G_3 k59_78032_1 1319815.HMPREF0202_02704 2.06e-118 348.0 2CFD0@1|root,2ZCIA@2|Bacteria,37A1R@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_78032_2 1078085.HMPREF1210_02851 1.69e-14 75.1 COG2199@1|root,COG2199@2|Bacteria,1UI4C@1239|Firmicutes,4HCZC@91061|Bacilli 91061|Bacilli T Diguanylate cyclase - - - - - - - - - - - - CBS,GGDEF k59_78032_3 1122963.AUHB01000006_gene2396 9.08e-179 509.0 COG1979@1|root,COG1979@2|Bacteria,1QUBJ@1224|Proteobacteria 1224|Proteobacteria C alcohol dehydrogenase - - - ko:K19955 - - - - ko00000,ko01000 - - - Fe-ADH k59_78032_4 385682.AFSL01000088_gene906 2.83e-147 429.0 COG1979@1|root,COG1979@2|Bacteria,4NF1D@976|Bacteroidetes,2FPAW@200643|Bacteroidia,3XISF@558415|Marinilabiliaceae 976|Bacteroidetes C Iron-containing alcohol dehydrogenase - - - ko:K19955 - - - - ko00000,ko01000 - - - Fe-ADH k59_78032_5 1423321.AS29_10855 2.07e-23 95.1 COG0789@1|root,COG0789@2|Bacteria,1V3QI@1239|Firmicutes,4HH53@91061|Bacilli,1ZFTI@1386|Bacillus 91061|Bacilli K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_78032_7 1408439.JHXW01000001_gene1821 5.82e-130 385.0 COG4394@1|root,COG4394@2|Bacteria,3795P@32066|Fusobacteria 32066|Fusobacteria S Uncharacterized protein conserved in bacteria (DUF2331) - - - - - - - - - - - - DUF2331 k59_78032_8 469616.FMAG_00758 5.52e-117 336.0 COG0231@1|root,COG0231@2|Bacteria,378D7@32066|Fusobacteria 32066|Fusobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_78032_9 572544.Ilyop_1567 3.3e-287 805.0 COG0514@1|root,COG0514@2|Bacteria,3790Q@32066|Fusobacteria 32066|Fusobacteria L RQC - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_78032_10 572544.Ilyop_1605 3.51e-156 446.0 COG0598@1|root,COG0598@2|Bacteria,378CB@32066|Fusobacteria 32066|Fusobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_78032_11 572544.Ilyop_0502 2.77e-44 148.0 2C6XX@1|root,2ZG6V@2|Bacteria 2|Bacteria S Domain of unknown function (DUF5348) - - - - - - - - - - - - DUF5348 k59_78032_12 1298593.TOL_0242 7.45e-59 221.0 COG0642@1|root,COG0784@1|root,COG2199@1|root,COG5001@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - DUF2222,EAL,GGDEF,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_78032_13 572544.Ilyop_2824 2.68e-46 150.0 2C82G@1|root,32RK9@2|Bacteria 2|Bacteria S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_78032_14 1232410.KI421413_gene852 4.64e-63 196.0 COG0599@1|root,COG0599@2|Bacteria 2|Bacteria S peroxiredoxin activity pcaC - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_78032_16 1280941.HY2_14095 8.84e-09 53.9 COG0433@1|root,COG0433@2|Bacteria,1QXYS@1224|Proteobacteria,2UHW9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S KTSC domain - - - - - - - - - - - - KTSC k59_78032_17 879212.DespoDRAFT_00348 1.91e-43 150.0 2AR2D@1|root,31GBD@2|Bacteria,1QE32@1224|Proteobacteria,432R1@68525|delta/epsilon subdivisions,2WXPH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF4412) - - - - - - - - - - - - DUF4412 k59_667243_1 709032.Sulku_2654 1.12e-61 213.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YM7R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Efflux pump membrane transporter - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_634241_1 1210884.HG799463_gene10136 1.14e-33 129.0 COG2986@1|root,COG2986@2|Bacteria,2IZUM@203682|Planctomycetes 203682|Planctomycetes E Aromatic amino acid lyase - - 4.3.1.24 ko:K10775 ko00360,ko00940,ko01100,ko01110,map00360,map00940,map01100,map01110 M00039,M00137,M00350 R00697 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_634241_2 1220551.SCHR_06535 1.02e-41 150.0 COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,4H9NH@91061|Bacilli,4GYPU@90964|Staphylococcaceae 91061|Bacilli E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_928568_1 671065.MetMK1DRAFT_00019530 1.06e-44 156.0 COG1741@1|root,arCOG02935@2157|Archaea,2XRMP@28889|Crenarchaeota 28889|Crenarchaeota S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_928568_2 1227360.C176_20324 1.65e-29 112.0 COG1671@1|root,COG1671@2|Bacteria,1V9Z0@1239|Firmicutes,4HM1G@91061|Bacilli,26F3Q@186818|Planococcaceae 91061|Bacilli S Belongs to the UPF0178 family - - - ko:K09768 - - - - ko00000 - - - DUF188 k59_928568_3 572544.Ilyop_0209 1.06e-167 532.0 COG2982@1|root,COG3164@1|root,COG2982@2|Bacteria,COG3164@2|Bacteria 2|Bacteria D Protein of unknown function MA20_30770 - - ko:K09800 - - - - ko00000,ko02000 - - - AsmA_2,DUF3971,TamB k59_928568_4 768670.Calni_1003 2.07e-219 624.0 COG0513@1|root,COG0513@2|Bacteria,2GENS@200930|Deferribacteres 200930|Deferribacteres L helicase superfamily c-terminal domain - - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_928568_5 1443125.Z962_11415 1.71e-51 167.0 COG1051@1|root,COG1051@2|Bacteria,1VC1Q@1239|Firmicutes,24VJ5@186801|Clostridia,36PRV@31979|Clostridiaceae 186801|Clostridia F Belongs to the Nudix hydrolase family - - - - - - - - - - - - NUDIX k59_829721_1 713587.THITH_01775 7.35e-62 196.0 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0209 Ribonucleotide reductase, alpha subunit nrdJb - - - - - - - - - - - - k59_272718_1 3702.ATCG01100.1 2.78e-100 300.0 COG1005@1|root,KOG4770@2759|Eukaryota,37RCJ@33090|Viridiplantae,3GDCI@35493|Streptophyta 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0015979,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0019866,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0055114,GO:0070469,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K05572 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - NADHdh k59_1032655_1 1401067.HMPREF0872_05200 3.75e-06 47.4 COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,4H2U2@909932|Negativicutes 909932|Negativicutes E Acetolactate synthase, small subunit ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_869421_1 572477.Alvin_2794 1.18e-68 221.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_641755_1 1476973.JMMB01000007_gene951 1.73e-62 206.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,25R9C@186804|Peptostreptococcaceae 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_50852_1 519989.ECTPHS_06582 3.83e-66 223.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WXM6@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_609144_1 2340.JV46_16790 5.55e-85 272.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1J5IS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_801691_1 187272.Mlg_2575 2.09e-83 268.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria,1WWS0@135613|Chromatiales 135613|Chromatiales P inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_837771_1 632245.CLP_3133 1.82e-109 330.0 COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,248X0@186801|Clostridia,36EXV@31979|Clostridiaceae 186801|Clostridia G solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 k59_837771_2 1118054.CAGW01000050_gene1237 4.97e-81 260.0 COG2223@1|root,COG2223@2|Bacteria,1UJR3@1239|Firmicutes,4ITDR@91061|Bacilli,26S65@186822|Paenibacillaceae 91061|Bacilli P COG0477 Permeases of the major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_837771_3 935948.KE386494_gene745 4.51e-28 110.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,42FX4@68295|Thermoanaerobacterales 186801|Clostridia G PFAM glycoside hydrolase, family 4 - - 3.2.1.22 ko:K07406 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_4,Glyco_hydro_4C k59_869980_1 1168034.FH5T_10795 3.08e-135 398.0 COG0608@1|root,COG0608@2|Bacteria,4NDW1@976|Bacteroidetes,2FMH0@200643|Bacteroidia 976|Bacteroidetes L single-stranded-DNA-specific exonuclease recJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_642334_2 1121405.dsmv_2192 1.03e-21 93.6 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,42N42@68525|delta/epsilon subdivisions,2WK62@28221|Deltaproteobacteria,2MI73@213118|Desulfobacterales 28221|Deltaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_280462_1 1249480.B649_03315 1.67e-95 288.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2YMA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM k59_86019_1 1168034.FH5T_11890 2.14e-82 259.0 COG0769@1|root,COG0769@2|Bacteria,4NE9W@976|Bacteroidetes,2FM8E@200643|Bacteroidia 976|Bacteroidetes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_968666_1 1122603.ATVI01000005_gene3496 5.42e-51 181.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9IC@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - - k59_968666_2 883126.HMPREF9710_00076 4.09e-96 292.0 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,47249@75682|Oxalobacteraceae 28216|Betaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_152668_1 521011.Mpal_1981 6.28e-44 152.0 COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,2N9X7@224756|Methanomicrobia 224756|Methanomicrobia O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K01802,ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_152668_2 1232429.CBLL010000163_gene1424 2.35e-32 125.0 COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,1W82N@1268|Micrococcaceae 201174|Actinobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_280472_1 709032.Sulku_2256 4.19e-25 98.6 COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,42S7E@68525|delta/epsilon subdivisions,2YP7T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q 2-keto-4-pentenoate hydratase - - - - - - - - - - - - FAA_hydrolase k59_707227_1 1485544.JQKP01000013_gene1798 1.77e-36 132.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,44V3T@713636|Nitrosomonadales 28216|Betaproteobacteria G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_707227_2 863365.XHC_1502 1.02e-33 121.0 COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1X64C@135614|Xanthomonadales 135614|Xanthomonadales S CYTH domain protein - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_544362_1 1172190.M947_04745 9.85e-151 439.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2YMWR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_412596_1 1121405.dsmv_0036 8.86e-87 280.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MI4Z@213118|Desulfobacterales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_772505_1 1168034.FH5T_05460 2.42e-103 304.0 COG1212@1|root,COG1212@2|Bacteria,4NG4B@976|Bacteroidetes,2FMHD@200643|Bacteroidia 976|Bacteroidetes M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_772505_2 1168034.FH5T_05455 7.81e-118 347.0 COG2204@1|root,COG2204@2|Bacteria,4NDWI@976|Bacteroidetes,2FMNM@200643|Bacteroidia 976|Bacteroidetes K Sigma-54 interaction domain protein fhlA - - - - - - - - - - - HTH_8,Sigma54_activat k59_119095_1 234267.Acid_7772 9.5e-18 82.4 2BXG3@1|root,2Z82R@2|Bacteria,3Y3HC@57723|Acidobacteria 57723|Acidobacteria S tagaturonate epimerase - - 5.1.2.7 ko:K21619 ko00040,ko01100,map00040,map01100 - R11624 - ko00000,ko00001,ko01000 - - - UxaE k59_119095_2 1408473.JHXO01000011_gene3174 4.06e-39 142.0 COG0362@1|root,COG0362@2|Bacteria,4NG05@976|Bacteroidetes,2FMFW@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_444943_1 945713.IALB_2269 1.14e-27 112.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid ytnP - - - - - - - - - - - Lactamase_B k59_217685_1 998674.ATTE01000001_gene301 8.39e-36 126.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,460JZ@72273|Thiotrichales 72273|Thiotrichales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_217685_2 626887.J057_05031 1.64e-42 148.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,465QJ@72275|Alteromonadaceae 1236|Gammaproteobacteria D Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_772514_1 1178825.ALIH01000010_gene467 6.75e-74 231.0 COG0697@1|root,COG0697@2|Bacteria,4NE8D@976|Bacteroidetes,1HXCW@117743|Flavobacteriia 976|Bacteroidetes EG Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_249345_1 1121396.KB892946_gene2897 1.78e-112 348.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MHZ1@213118|Desulfobacterales 28221|Deltaproteobacteria S Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - MMPL k59_801708_1 387093.SUN_0722 7.88e-69 228.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,42M9U@68525|delta/epsilon subdivisions,2YNJP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K RNA binding S1 domain protein - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_801708_2 243090.RB11273 1.94e-15 76.6 COG0477@1|root,COG2814@2|Bacteria,2J067@203682|Planctomycetes 203682|Planctomycetes EGP Major facilitator superfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_380399_1 1172190.M947_02910 3.55e-50 172.0 COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,42M6F@68525|delta/epsilon subdivisions,2YMXE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase, class I patB - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_477861_1 469616.FMAG_01511 9.33e-26 107.0 COG0028@1|root,COG0028@2|Bacteria,378RW@32066|Fusobacteria 32066|Fusobacteria H acetolactate synthase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_477861_2 936589.HMPREF1521_1664 8.29e-189 536.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4H1WE@909932|Negativicutes 909932|Negativicutes E threonine ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,PALP k59_477861_3 526218.Sterm_0102 1.76e-192 551.0 COG0129@1|root,COG0129@2|Bacteria,378WV@32066|Fusobacteria 32066|Fusobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_675592_1 519989.ECTPHS_02199 8.33e-34 121.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1WYG6@135613|Chromatiales 135613|Chromatiales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_185224_1 159087.Daro_0468 8.8e-22 101.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VHNB@28216|Betaproteobacteria,2M01T@206389|Rhodocyclales 206389|Rhodocyclales L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_51472_1 1123514.KB905899_gene1989 7.98e-77 243.0 COG0531@1|root,COG0531@2|Bacteria,1PKIV@1224|Proteobacteria,1T9HU@1236|Gammaproteobacteria,461MJ@72273|Thiotrichales 72273|Thiotrichales E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_349004_1 709032.Sulku_2532 8.19e-28 108.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,42P59@68525|delta/epsilon subdivisions,2YMPJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0324 family - - - - - - - - - - - - Cons_hypoth698 k59_801726_1 1249480.B649_04220 6.25e-61 199.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2YMJQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.92 ko:K15895 ko00520,map00520 - R09825 RC00006,RC00781 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 k59_86058_1 795666.MW7_0272 9.64e-30 122.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae 28216|Betaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - CHASE,EAL,GGDEF,MASE3,PAS_3,PAS_4,PAS_7,PAS_9 k59_86058_2 317655.Sala_1242 1.05e-24 102.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria,2K1KA@204457|Sphingomonadales 204457|Sphingomonadales C L-carnitine dehydratase bile acid-inducible protein F - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_544376_1 933262.AXAM01000044_gene1408 2.99e-74 236.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2MKFC@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_707251_1 1479237.JMLY01000001_gene1513 8.04e-37 134.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,464MX@72275|Alteromonadaceae 1236|Gammaproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_837804_1 96561.Dole_3014 9.41e-94 276.0 COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,42QRV@68525|delta/epsilon subdivisions,2WMUE@28221|Deltaproteobacteria,2MJY2@213118|Desulfobacterales 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_801735_1 59538.XP_005976884.1 6.25e-37 138.0 COG0466@1|root,KOG2004@2759|Eukaryota,38E0Y@33154|Opisthokonta,3BCE6@33208|Metazoa,3CT0G@33213|Bilateria,484SC@7711|Chordata,492UD@7742|Vertebrata,3J8KK@40674|Mammalia,4J7VF@91561|Cetartiodactyla 33208|Metazoa O Lon protease homolog 2 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0006508,GO:0006605,GO:0006625,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015031,GO:0015833,GO:0016043,GO:0016485,GO:0019538,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043574,GO:0044238,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051604,GO:0051641,GO:0051649,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564 3.4.21.53 ko:K01338,ko:K08675 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002,ko03029 - - - AAA,LON_substr_bdg,Lon_C k59_801735_2 2340.JV46_28080 1.15e-55 179.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1J4TT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_119119_2 395963.Bind_2588 3.11e-05 48.5 2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,2UE0N@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Thermostable hemolysin - - - - - - - - - - - - T_hemolysin k59_444968_1 292415.Tbd_0872 6.77e-54 185.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria,1KS3F@119069|Hydrogenophilales 119069|Hydrogenophilales C FAD binding domain - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_609839_2 243231.GSU1277 3.7e-37 130.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,42SDX@68525|delta/epsilon subdivisions,2WP41@28221|Deltaproteobacteria,43SYB@69541|Desulfuromonadales 28221|Deltaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_152716_1 869213.JCM21142_519 4.51e-18 89.0 COG1131@1|root,COG1131@2|Bacteria,4NHPD@976|Bacteroidetes,47KQD@768503|Cytophagia 976|Bacteroidetes V ABC-2 type transporter - - - - - - - - - - - - ABC2_membrane,ABC_tran k59_477887_1 1392490.JHZX01000001_gene758 5.3e-104 311.0 COG0667@1|root,COG0667@2|Bacteria,4NHA1@976|Bacteroidetes,1HZQF@117743|Flavobacteriia 976|Bacteroidetes C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_15705_1 1250005.PHEL85_1507 4.07e-05 51.6 COG0596@1|root,COG0596@2|Bacteria,4NIQH@976|Bacteroidetes,1IG08@117743|Flavobacteriia,3VXC9@52959|Polaribacter 976|Bacteroidetes S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_1001901_1 1114959.SZMC14600_13022 1.59e-11 71.6 COG0526@1|root,COG0526@2|Bacteria,2GKDT@201174|Actinobacteria,4DZI9@85010|Pseudonocardiales 201174|Actinobacteria CO NHL repeat - - - - - - - - - - - - AhpC-TSA,NHL,Thioredoxin_8 k59_15707_1 396588.Tgr7_2226 7.44e-85 256.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WW37@135613|Chromatiales 135613|Chromatiales O Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_313991_2 675812.VHA_002700 2.41e-53 176.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,1XT48@135623|Vibrionales 135623|Vibrionales P Spermidine putrescine ABC transporter potC - - ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 k59_675629_1 1163407.UU7_09045 2.92e-92 290.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1X3GK@135614|Xanthomonadales 135614|Xanthomonadales S COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_8 k59_444979_1 1429916.X566_02050 4.36e-06 53.5 COG1414@1|root,COG1414@2|Bacteria,1R9EX@1224|Proteobacteria,2TRPP@28211|Alphaproteobacteria,3JXXN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_1033309_2 717772.THIAE_04360 3.04e-61 198.0 COG0463@1|root,COG0463@2|Bacteria,1RGMI@1224|Proteobacteria,1S525@1236|Gammaproteobacteria,4618G@72273|Thiotrichales 72273|Thiotrichales M transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_15712_1 572544.Ilyop_0199 1.66e-51 169.0 COG0500@1|root,COG2226@2|Bacteria,37CTJ@32066|Fusobacteria 32066|Fusobacteria Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_25 k59_968735_2 387093.SUN_0987 9.94e-30 111.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2YQ46@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA k59_609852_1 713586.KB900536_gene1549 2.16e-131 391.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1WW0Q@135613|Chromatiales 135613|Chromatiales EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_280556_1 1168034.FH5T_16725 6.55e-94 277.0 COG0742@1|root,COG0742@2|Bacteria,4NM7J@976|Bacteroidetes,2FSR0@200643|Bacteroidia 976|Bacteroidetes L RNA methyltransferase, RsmD family rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_119153_1 1048983.EL17_18310 2.61e-41 159.0 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,47JBS@768503|Cytophagia 976|Bacteroidetes T Two component regulator propeller - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_249386_2 177437.HRM2_45900 1.06e-15 77.4 COG3087@1|root,COG3087@2|Bacteria,1RFDE@1224|Proteobacteria,42RRT@68525|delta/epsilon subdivisions,2WN8I@28221|Deltaproteobacteria,2MK2D@213118|Desulfobacterales 28221|Deltaproteobacteria D Sporulation related domain - - - - - - - - - - - - SPOR k59_837833_1 1168034.FH5T_19500 3.05e-75 250.0 COG1470@1|root,COG1470@2|Bacteria,4NFPN@976|Bacteroidetes,2FMUB@200643|Bacteroidia 976|Bacteroidetes S COG NOG25960 non supervised orthologous group - - - - - - - - - - - - CarbopepD_reg_2 k59_412651_2 1049564.TevJSym_bd00310 2.79e-63 201.0 COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,1RNK9@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases asrB - - ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_217752_1 472759.Nhal_2549 1.21e-21 89.4 COG0071@1|root,COG0071@2|Bacteria,1RH6E@1224|Proteobacteria,1S6FC@1236|Gammaproteobacteria,1WYSM@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_217752_2 744980.TRICHSKD4_1993 1.54e-14 75.1 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2TR14@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_544438_1 1122975.AQVC01000013_gene976 6.32e-20 97.8 COG1649@1|root,COG1649@2|Bacteria,4NHEB@976|Bacteroidetes,2FMZJ@200643|Bacteroidia,22XHM@171551|Porphyromonadaceae 976|Bacteroidetes S Glycosyl hydrolase-like 10 - - - - - - - - - - - - GHL10 k59_576820_1 563040.Saut_0712 4e-39 137.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2YPJ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_903344_1 1049564.TevJSym_ac00200 8.64e-92 276.0 COG1575@1|root,COG1575@2|Bacteria,1PKCZ@1224|Proteobacteria,1SXAN@1236|Gammaproteobacteria,1J9HU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_1033331_1 886379.AEWI01000018_gene1289 3.93e-77 243.0 COG1180@1|root,COG1180@2|Bacteria,4NJ18@976|Bacteroidetes,2FQZB@200643|Bacteroidia,3XM0S@558415|Marinilabiliaceae 976|Bacteroidetes O Radical SAM superfamily - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_968765_1 1537917.JU82_10775 6.25e-08 56.6 COG0745@1|root,COG0745@2|Bacteria,1QXJT@1224|Proteobacteria,42V47@68525|delta/epsilon subdivisions,2YQ8S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT RESPONSE REGULATOR receiver - - - ko:K07288 - - - - ko00000 - - - - k59_124667_1 396588.Tgr7_2684 2.53e-101 303.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C6@1236|Gammaproteobacteria,1WXH4@135613|Chromatiales 135613|Chromatiales C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_286114_1 1049564.TevJSym_ap00490 1.31e-55 188.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1J5NF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_582557_1 1211114.ALIP01000083_gene1523 4.39e-55 183.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1X3JR@135614|Xanthomonadales 135614|Xanthomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa k59_582557_2 1045855.DSC_07070 1.69e-18 81.3 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1X3TC@135614|Xanthomonadales 135614|Xanthomonadales C NADH dehydrogenase nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_482526_1 794903.OPIT5_23505 1.78e-67 229.0 COG1196@1|root,COG1196@2|Bacteria,46TT8@74201|Verrucomicrobia,3K7E6@414999|Opitutae 414999|Opitutae D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_386358_1 572544.Ilyop_0751 2.06e-109 337.0 COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,37BIB@32066|Fusobacteria 32066|Fusobacteria G TIGRFAM PTS system, fructose subfamily, IIC subunit - - 2.7.1.195 ko:K11198,ko:K11199,ko:K11200 ko02060,map02060 M00305 R11169 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1.3 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB k59_386363_1 1220583.GOACH_04_00770 2.87e-38 142.0 COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4GCND@85026|Gordoniaceae 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_56852_1 1408445.JHXP01000003_gene1095 4.36e-53 182.0 COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,1RPQW@1236|Gammaproteobacteria,1JCU1@118969|Legionellales 118969|Legionellales C Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate astD - 1.2.1.71 ko:K06447 ko00330,ko01100,map00330,map01100 - R05049 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_875472_2 1168034.FH5T_08620 1.96e-60 191.0 2CAZH@1|root,2Z7RU@2|Bacteria,4NGM5@976|Bacteroidetes,2FM2S@200643|Bacteroidia 976|Bacteroidetes S Succinate dehydrogenase cytochrome B subunit, b558 family sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_254771_1 485916.Dtox_1611 3.53e-38 139.0 COG0535@1|root,COG0535@2|Bacteria,1URM8@1239|Firmicutes,24XB8@186801|Clostridia 186801|Clostridia C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_158762_1 563040.Saut_0119 1.02e-60 198.0 COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,42SX1@68525|delta/epsilon subdivisions,2YPG3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_450976_1 435830.HMPREF0045_00725 4.65e-75 245.0 COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4D3EP@85005|Actinomycetales 201174|Actinobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_386374_1 743299.Acife_0675 1.35e-197 580.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,2NDMP@225057|Acidithiobacillales 225057|Acidithiobacillales F Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_286142_1 768671.ThimaDRAFT_3775 2.55e-58 199.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales 135613|Chromatiales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_21261_1 1265505.ATUG01000002_gene2697 1.09e-54 174.0 2AIN5@1|root,3194H@2|Bacteria,1RKDN@1224|Proteobacteria,42SYA@68525|delta/epsilon subdivisions,2WPD1@28221|Deltaproteobacteria,2MJWF@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3842) - - - - - - - - - - - - DUF3842 k59_450977_1 237368.SCABRO_03845 9.79e-15 71.2 2EH29@1|root,33AU8@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_124689_1 745718.JADT01000007_gene2726 4.44e-22 102.0 COG4531@1|root,COG4531@2|Bacteria,4NF0R@976|Bacteroidetes,1HY1X@117743|Flavobacteriia 976|Bacteroidetes P Quinol cytochrome c oxidoreductase actF - - - - - - - - - - - - k59_286145_1 1307759.JOMJ01000003_gene1650 4.02e-07 51.6 COG2197@1|root,COG2197@2|Bacteria,1MXI3@1224|Proteobacteria,42WHD@68525|delta/epsilon subdivisions,2WSDG@28221|Deltaproteobacteria,2MDDQ@213115|Desulfovibrionales 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_21262_2 1265313.HRUBRA_00129 1.33e-73 229.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1J5PS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_908334_1 1168034.FH5T_04015 1.62e-91 300.0 COG4797@1|root,COG4797@2|Bacteria,4PKQS@976|Bacteroidetes,2FP69@200643|Bacteroidia 976|Bacteroidetes S Motility related/secretion protein sprA - - - - - - - - - - - SprA_N k59_842873_1 1168034.FH5T_06770 2.79e-34 129.0 COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,2FMTR@200643|Bacteroidia 976|Bacteroidetes IQ Psort location Cytoplasmic, score 9.97 - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1006977_1 765914.ThisiDRAFT_1016 1.16e-125 385.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_158774_1 1172190.M947_03935 6.22e-50 176.0 COG1256@1|root,COG1749@1|root,COG1256@2|Bacteria,COG1749@2|Bacteria,1MV2M@1224|Proteobacteria,42PBN@68525|delta/epsilon subdivisions,2YMGR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_712581_1 1454004.AW11_02018 4.31e-78 247.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_56885_1 869213.JCM21142_137 2.24e-91 282.0 COG3303@1|root,COG3303@2|Bacteria,4NG0P@976|Bacteroidetes,47JAN@768503|Cytophagia 976|Bacteroidetes C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process nrfA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 k59_680888_1 358681.BBR47_39890 3.16e-52 189.0 COG0236@1|root,COG0500@1|root,COG3321@1|root,COG0236@2|Bacteria,COG2226@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HK8P@91061|Bacilli 91061|Bacilli Q Beta-ketoacyl synthase, N-terminal domain - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_1006980_2 1056495.Calag_1420 2.84e-39 141.0 COG2518@1|root,arCOG00976@2157|Archaea,2XS79@28889|Crenarchaeota 28889|Crenarchaeota Q Ribosomal RNA adenine dimethylase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_875510_2 1120953.AUBH01000001_gene715 3.01e-37 134.0 29KMP@1|root,307IZ@2|Bacteria,1REJ6@1224|Proteobacteria,1S7K0@1236|Gammaproteobacteria,46AUR@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4287) - - - - - - - - - - - - DUF4287 k59_124704_1 861360.AARI_29190 6.97e-36 136.0 COG3949@1|root,COG3949@2|Bacteria,2IEGE@201174|Actinobacteria,1W8WS@1268|Micrococcaceae 201174|Actinobacteria S Membrane - - - - - - - - - - - - - k59_680889_1 1042163.BRLA_c017950 7.5e-53 174.0 2EBJH@1|root,335JZ@2|Bacteria,1VG00@1239|Firmicutes,4HQFE@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k59_386397_1 1408428.JNJP01000009_gene1397 6.52e-39 148.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2MG50@213115|Desulfovibrionales 28221|Deltaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_417622_1 314285.KT71_03017 3.17e-46 170.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT6@1236|Gammaproteobacteria,1J7Y7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_21287_1 572544.Ilyop_1750 2.74e-193 556.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,37934@32066|Fusobacteria 32066|Fusobacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2 k59_712596_2 1385935.N836_24980 6.17e-36 129.0 COG0748@1|root,COG0748@2|Bacteria,1G7II@1117|Cyanobacteria,1HC0W@1150|Oscillatoriales 1117|Cyanobacteria P Pfam:Pyridox_oxidase - - - ko:K07226 - - - - ko00000 - - - Putative_PNPOx k59_778849_1 1121403.AUCV01000031_gene2857 6.44e-98 303.0 29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria,431AV@68525|delta/epsilon subdivisions,2WWN5@28221|Deltaproteobacteria,2MNY5@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_287194_1 385682.AFSL01000062_gene1612 5.84e-41 137.0 COG0234@1|root,COG0234@2|Bacteria,4P42G@976|Bacteroidetes,2FYFP@200643|Bacteroidia,3XKB4@558415|Marinilabiliaceae 976|Bacteroidetes O Chaperonin 10 Kd subunit - - - - - - - - - - - - Cpn10 k59_287194_2 1168034.FH5T_16865 3.12e-71 219.0 COG3118@1|root,COG3118@2|Bacteria,4NQNX@976|Bacteroidetes,2FUHX@200643|Bacteroidia 976|Bacteroidetes O Thioredoxin trxA2 - - - - - - - - - - - Thioredoxin k59_287194_3 1408473.JHXO01000004_gene265 2.53e-31 116.0 COG0526@1|root,COG0695@1|root,COG0526@2|Bacteria,COG0695@2|Bacteria,4P326@976|Bacteroidetes,2FXYW@200643|Bacteroidia 976|Bacteroidetes O Glutaredoxin - - - - - - - - - - - - Glutaredoxin k59_483292_1 240302.BN982_03961 2.27e-18 89.4 COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,4HAXE@91061|Bacilli 91061|Bacilli T Domain of unknown function (DUF4173) - - - - - - - - - - - - DUF4173 k59_255772_1 886293.Sinac_4759 7.74e-21 94.7 COG4584@1|root,COG4584@2|Bacteria,2J4C3@203682|Planctomycetes 203682|Planctomycetes L PFAM Integrase core domain - - - - - - - - - - - - rve k59_876338_1 445970.ALIPUT_00645 6.1e-13 66.6 COG0097@1|root,COG0097@2|Bacteria,4NGJM@976|Bacteroidetes,2FNEG@200643|Bacteroidia,22UZ3@171550|Rikenellaceae 976|Bacteroidetes J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_876338_2 1499968.TCA2_5543 1.09e-29 110.0 COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,4HIGF@91061|Bacilli,26XMJ@186822|Paenibacillaceae 91061|Bacilli J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_648816_1 1218074.BAXZ01000006_gene1751 3.54e-06 48.1 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,1K0CZ@119060|Burkholderiaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_159814_2 1132855.KB913035_gene2292 2.44e-21 94.0 COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,2VXI0@28216|Betaproteobacteria,2KMZH@206350|Nitrosomonadales 206350|Nitrosomonadales S signal sequence binding - - - - - - - - - - - - - k59_807803_1 572544.Ilyop_1719 6.99e-128 381.0 COG0595@1|root,COG0595@2|Bacteria,378XM@32066|Fusobacteria 32066|Fusobacteria J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_942698_1 269797.Mbar_A1583 8.2e-20 87.4 COG2426@1|root,arCOG01330@2157|Archaea,2XZ2Y@28890|Euryarchaeota,2NAQX@224756|Methanomicrobia 224756|Methanomicrobia S Putative small multi-drug export protein - - - - - - - - - - - - Sm_multidrug_ex k59_942698_2 886293.Sinac_7277 5.03e-11 63.2 COG0694@1|root,COG0694@2|Bacteria 2|Bacteria O iron-sulfur cluster assembly nfuA - - ko:K07400 - - - - ko00000 - - - Nfu_N,NifU k59_616044_1 1370125.AUWT01000013_gene1883 1.71e-38 147.0 COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,2337J@1762|Mycobacteriaceae 201174|Actinobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_551075_1 237368.SCABRO_03622 1.39e-12 67.8 COG1290@1|root,COG1290@2|Bacteria,2J2NY@203682|Planctomycetes 203682|Planctomycetes C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - - - - - - - - - - - k59_681789_1 1158756.AQXQ01000009_gene1049 2.15e-58 204.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_159820_1 944435.AXAJ01000023_gene5165 1.54e-95 297.0 COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,2VJ41@28216|Betaproteobacteria,1K1GC@119060|Burkholderiaceae 28216|Betaproteobacteria O Belongs to the heat shock protein 70 family - - - - - - - - - - - - HSP70 k59_125605_1 1165841.SULAR_04617 2.34e-69 211.0 COG0789@1|root,COG0789@2|Bacteria,1N948@1224|Proteobacteria,42SGY@68525|delta/epsilon subdivisions,2YPH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator hspR - - ko:K13640 - - - - ko00000,ko03000 - - - MerR_1 k59_125605_2 1165841.SULAR_04622 2.79e-12 65.1 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2YMSY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Co-chaperone-curved DNA binding protein A cbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_1040130_1 1540257.JQMW01000009_gene2914 2.43e-45 164.0 COG3835@1|root,COG3835@2|Bacteria,1TQWD@1239|Firmicutes,24ZMW@186801|Clostridia,36UMG@31979|Clostridiaceae 186801|Clostridia KT Purine catabolism regulatory protein-like family - - - ko:K09684 - - - - ko00000,ko03000 - - - HTH_30,PucR k59_713527_1 572544.Ilyop_1696 1.36e-70 216.0 COG0716@1|root,COG0716@2|Bacteria,37A1T@32066|Fusobacteria 32066|Fusobacteria C Low-potential electron donor to a number of redox enzymes - - - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 k59_713527_2 1408439.JHXW01000002_gene647 8.71e-26 101.0 COG1179@1|root,COG1179@2|Bacteria,378E2@32066|Fusobacteria 32066|Fusobacteria H thiamine biosynthesis protein ThiF - - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_125608_1 572480.Arnit_0082 2.23e-38 137.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YNBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_125608_2 1123326.JFBL01000001_gene1266 1.22e-27 110.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,42MHB@68525|delta/epsilon subdivisions,2YNUZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase cofactor biosynthesis protein NifB - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_1040134_1 1121405.dsmv_2240 1.06e-56 179.0 arCOG10385@1|root,32SEM@2|Bacteria,1N1IG@1224|Proteobacteria,42TMW@68525|delta/epsilon subdivisions,2WQBW@28221|Deltaproteobacteria,2MK19@213118|Desulfobacterales 28221|Deltaproteobacteria - - dsrJ - - - - - - - - - - - - k59_1040134_2 879212.DespoDRAFT_03016 0.000353 43.5 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,42MNU@68525|delta/epsilon subdivisions,2WJRG@28221|Deltaproteobacteria,2MIME@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein dsrO - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_4 k59_483311_1 1122921.KB898185_gene4285 1.44e-72 240.0 COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,4HFBX@91061|Bacilli,26RCV@186822|Paenibacillaceae 91061|Bacilli G Cellobiose phosphorylase chvB3 - 2.4.1.20 ko:K00702 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000 - GT36 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_681800_1 1255043.TVNIR_0254 5.86e-23 97.8 COG1075@1|root,COG1075@2|Bacteria 2|Bacteria KLT acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - ko:K09384 - - - - ko00000 - - - Abhydrolase_8,PGAP1 k59_519360_1 331678.Cphamn1_0514 1.1e-49 184.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - HemolysinCabind k59_92724_1 270374.MELB17_19786 3.32e-09 57.8 COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - Patatin k59_92724_2 1396858.Q666_00745 2.19e-22 95.1 COG3937@1|root,COG3937@2|Bacteria,1N7X8@1224|Proteobacteria,1T08C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Polyhydroxyalkanoate granule-associated protein - - - - - - - - - - - - Phasin k59_92724_3 998088.B565_1980 5.99e-55 182.0 2AYXV@1|root,31R3M@2|Bacteria,1RHPG@1224|Proteobacteria,1SYAS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_807835_1 933262.AXAM01000040_gene1231 2.35e-59 190.0 29GM5@1|root,303IT@2|Bacteria,1RG3T@1224|Proteobacteria,42RUX@68525|delta/epsilon subdivisions,2WNMJ@28221|Deltaproteobacteria,2MJY1@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_583383_1 314271.RB2654_01070 4.1e-13 68.6 COG0596@1|root,COG0596@2|Bacteria,1Q04Z@1224|Proteobacteria,2UMMG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1 k59_946438_1 1168034.FH5T_20955 2.87e-62 216.0 COG1074@1|root,COG1074@2|Bacteria,4NEX4@976|Bacteroidetes,2FMHG@200643|Bacteroidia 976|Bacteroidetes L Belongs to the helicase family. UvrD subfamily addA - - - - - - - - - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C k59_391466_1 1168034.FH5T_10075 9.5e-41 139.0 COG1438@1|root,COG1438@2|Bacteria,4NSSS@976|Bacteroidetes,2FR3Q@200643|Bacteroidia 976|Bacteroidetes K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k59_391466_2 1168034.FH5T_10080 5.38e-229 633.0 COG0505@1|root,COG0505@2|Bacteria,4NEQI@976|Bacteroidetes,2FMSR@200643|Bacteroidia 976|Bacteroidetes F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_25578_1 1168034.FH5T_04125 2.28e-117 351.0 COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes,2FNDJ@200643|Bacteroidia 976|Bacteroidetes E Asparagine synthase, glutamine-hydrolyzing asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_290325_1 859657.RPSI07_mp0416 2.78e-54 174.0 COG1522@1|root,COG1522@2|Bacteria,1MZ9D@1224|Proteobacteria,2VSJ1@28216|Betaproteobacteria,1K775@119060|Burkholderiaceae 28216|Betaproteobacteria K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_61698_1 525898.Sdel_1045 2.21e-89 282.0 COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,42MPY@68525|delta/epsilon subdivisions,2YMV7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C phosphate acetyltransferase pta - 2.3.1.8 ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,DRTGG,PTA_PTB k59_456282_2 926569.ANT_09640 7.92e-54 179.0 COG0216@1|root,COG0216@2|Bacteria,2G5UD@200795|Chloroflexi 200795|Chloroflexi J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_95808_1 643562.Daes_0080 4.43e-52 180.0 COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42MVS@68525|delta/epsilon subdivisions,2WTJ7@28221|Deltaproteobacteria,2MG4Y@213115|Desulfovibrionales 28221|Deltaproteobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM k59_685674_1 391615.ABSJ01000022_gene293 1.72e-45 169.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_586966_1 1255043.TVNIR_3133 2.84e-55 177.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales 135613|Chromatiales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_586966_2 62928.azo1382 1.36e-93 304.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KUXH@206389|Rhodocyclales 206389|Rhodocyclales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_456290_1 1235798.C817_05291 8.91e-79 251.0 COG1321@1|root,COG1321@2|Bacteria,1UZX6@1239|Firmicutes,248DA@186801|Clostridia 186801|Clostridia K iron dependent repressor - - - - - - - - - - - - - k59_358505_1 397945.Aave_2860 3.55e-115 341.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,4AA00@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM isocitrate lyase and phosphorylmutase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_259225_1 382464.ABSI01000006_gene798 4.05e-37 139.0 COG4146@1|root,COG4146@2|Bacteria,46UV3@74201|Verrucomicrobia,2ITNB@203494|Verrucomicrobiae 2|Bacteria S Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_259225_2 1141663.OOC_04587 1.45e-84 257.0 COG0235@1|root,COG0235@2|Bacteria,1MU54@1224|Proteobacteria,1RMIP@1236|Gammaproteobacteria,3Z7WQ@586|Providencia 1236|Gammaproteobacteria G 4-epimerase araD GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046872,GO:0046914,GO:0071704,GO:1901575 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_847168_1 1284352.AOIG01000022_gene3799 5.88e-16 73.9 2BJ5J@1|root,32DEU@2|Bacteria,1U1FE@1239|Firmicutes,4IAXP@91061|Bacilli,273BU@186822|Paenibacillaceae 91061|Bacilli S Protein of unknown function (DUF2829) - - - - - - - - - - - - DUF2829 k59_812490_1 1288826.MSNKSG1_13992 5.24e-30 107.0 COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,1S688@1236|Gammaproteobacteria,4687U@72275|Alteromonadaceae 1236|Gammaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - ko:K09700 - - - - ko00000 - - - - k59_812490_2 247634.GPB2148_468 2.81e-59 188.0 COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,1S4K8@1236|Gammaproteobacteria,1J6A3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q DSBA-like thioredoxin domain - - 5.99.1.4 ko:K14584 ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220 M00534 R05137 RC03084 br01602,ko00000,ko00001,ko00002,ko01000 - - - DSBA k59_259939_1 1168034.FH5T_03450 9.99e-101 310.0 COG0443@1|root,COG0443@2|Bacteria,4NERF@976|Bacteroidetes,2FMNH@200643|Bacteroidia 976|Bacteroidetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_291101_1 314278.NB231_07537 6.34e-61 203.0 COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria,1RPE3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaB GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600 - ko:K03314 - - - - ko00000,ko02000 2.A.34.1 - iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372 NhaB k59_291101_2 765910.MARPU_02615 1.38e-87 266.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1WWJC@135613|Chromatiales 135613|Chromatiales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_587639_1 649638.Trad_0604 4.98e-32 126.0 COG1640@1|root,COG1640@2|Bacteria,1WJDF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM glycoside hydrolase, family 77 malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_324002_1 1168034.FH5T_04250 2.64e-220 633.0 COG4775@1|root,COG4775@2|Bacteria,4NE80@976|Bacteroidetes,2FM1J@200643|Bacteroidia 976|Bacteroidetes M Outer membrane protein, OMP85 family - - - - - - - - - - - - Bac_surface_Ag,POTRA k59_291103_1 1121405.dsmv_1865 2.58e-101 312.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,42P6Z@68525|delta/epsilon subdivisions,2WK5W@28221|Deltaproteobacteria,2MIDT@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Alpha amylase, catalytic treS - 2.4.1.4,2.4.1.7,3.2.1.1,5.4.99.16 ko:K00690,ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R00803,R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_62237_1 1123256.KB907926_gene668 3.35e-50 177.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1X31T@135614|Xanthomonadales 135614|Xanthomonadales OU signal peptide peptidase sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_686373_1 1168034.FH5T_05065 9.87e-93 284.0 COG0719@1|root,COG0719@2|Bacteria,4NFXH@976|Bacteroidetes,2FMUZ@200643|Bacteroidia 976|Bacteroidetes O FeS assembly protein SufB sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_686373_2 1168034.FH5T_05060 4.56e-86 263.0 COG0611@1|root,COG0611@2|Bacteria,4NDUT@976|Bacteroidetes,2FN7K@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_587646_1 765911.Thivi_0027 3.39e-18 85.9 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,1WX87@135613|Chromatiales 135613|Chromatiales S PFAM Paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA k59_587646_2 240016.ABIZ01000001_gene5786 2.1e-14 71.6 COG2995@1|root,COG2995@2|Bacteria,46W85@74201|Verrucomicrobia,2IUFF@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Paraquat-inducible protein A - - - - - - - - - - - - PqiA k59_1044283_1 1168034.FH5T_01455 5.46e-20 85.9 COG1773@1|root,COG1853@1|root,COG1773@2|Bacteria,COG1853@2|Bacteria,4NHF0@976|Bacteroidetes,2FUN6@200643|Bacteroidia 976|Bacteroidetes C rubredoxin rubR - - - - - - - - - - - Rubredoxin k59_259958_1 2340.JV46_19120 5.5e-69 221.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain dgcB - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_259958_2 1417296.U879_20705 2.61e-07 51.2 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,2UIT4@28211|Alphaproteobacteria 28211|Alphaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_979143_1 563040.Saut_1091 9.89e-24 99.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2YMQ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H acetolactate synthase ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_979143_2 1150621.SMUL_0919 1.37e-37 135.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,42TVJ@68525|delta/epsilon subdivisions 1224|Proteobacteria H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - iJN746.PP_0110,iSFxv_1172.SFxv_0410 UbiA k59_291122_1 111105.HR09_05120 4.8e-37 142.0 COG0793@1|root,COG0793@2|Bacteria,4NDWU@976|Bacteroidetes,2FM0W@200643|Bacteroidia,22W1I@171551|Porphyromonadaceae 976|Bacteroidetes M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_291122_2 1004149.AFOE01000029_gene2898 1.49e-37 136.0 COG0668@1|root,COG0668@2|Bacteria,4NFX6@976|Bacteroidetes,1HWPR@117743|Flavobacteriia 976|Bacteroidetes M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_847866_1 765914.ThisiDRAFT_1082 1.18e-71 222.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_26294_1 1121441.AUCX01000016_gene2355 9.45e-22 100.0 COG2911@1|root,COG2911@2|Bacteria,1QWGG@1224|Proteobacteria,43CG1@68525|delta/epsilon subdivisions,2X7R1@28221|Deltaproteobacteria,2MHE1@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_457112_1 1123399.AQVE01000001_gene684 3.68e-79 258.0 COG3291@1|root,COG5295@1|root,COG3291@2|Bacteria,COG5295@2|Bacteria,1RGWM@1224|Proteobacteria,1SKIX@1236|Gammaproteobacteria 1236|Gammaproteobacteria UW Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - Reprolysin_3 k59_947247_1 596153.Alide_4620 7.71e-55 179.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2VMVE@28216|Betaproteobacteria,4AD5D@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_392259_1 1283300.ATXB01000002_gene2696 3.12e-55 193.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XFKT@135618|Methylococcales 135618|Methylococcales T PFAM Chemotaxis methyl-accepting receptor, signalling - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_8,PAS_9,TarH k59_259988_1 1232437.KL662001_gene4635 1.13e-62 197.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,42STM@68525|delta/epsilon subdivisions,2WPAD@28221|Deltaproteobacteria,2MKSG@213118|Desulfobacterales 28221|Deltaproteobacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_783282_1 608534.GCWU000341_02786 2.79e-05 49.7 COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,2PQY2@265975|Oribacterium 186801|Clostridia J tRNA nucleotidyltransferase poly(A) polymerase family protein cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 k59_1044315_1 159087.Daro_1043 2.8e-53 179.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria,2KUD8@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_947263_1 35841.BT1A1_1473 9.52e-31 130.0 COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,4H9VQ@91061|Bacilli,1ZASE@1386|Bacillus 91061|Bacilli M Penicillin-binding Protein pbpX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PASTA,PBP_dimer,Transpeptidase k59_129825_1 1168034.FH5T_08875 3.5e-62 196.0 28P39@1|root,2ZBNA@2|Bacteria,4NN3I@976|Bacteroidetes,2G2KZ@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF5020) - - - - - - - - - - - - DUF5020 k59_620611_1 1535422.ND16A_0865 3.48e-97 293.0 COG2301@1|root,COG2301@2|Bacteria,1PCZW@1224|Proteobacteria,1SKSE@1236|Gammaproteobacteria 1236|Gammaproteobacteria G HpcH/HpaI aldolase/citrate lyase family - - - - - - - - - - - - HpcH_HpaI k59_324097_1 556269.ACDQ01000011_gene62 4.64e-67 229.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,473P9@75682|Oxalobacteraceae 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_947269_1 1121289.JHVL01000063_gene273 5.5e-55 189.0 COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,24F9G@186801|Clostridia,36VTR@31979|Clostridiaceae 186801|Clostridia E Sodium:solute symporter family - - - - - - - - - - - - SSF k59_587732_1 929558.SMGD1_2088 2.03e-33 121.0 COG0745@1|root,COG0745@2|Bacteria,1PGAE@1224|Proteobacteria,4348Y@68525|delta/epsilon subdivisions,2YREY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C k59_587732_2 326298.Suden_0617 1.65e-18 87.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42Z31@68525|delta/epsilon subdivisions,2YRAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Hpt sensor hybrid histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_291166_1 1121405.dsmv_3797 9.73e-78 246.0 COG4467@1|root,COG4467@2|Bacteria,1QW8C@1224|Proteobacteria 1224|Proteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_260005_1 1385511.N783_17620 9.27e-23 99.0 COG0258@1|root,COG0258@2|Bacteria,1TQ05@1239|Firmicutes,4H9UW@91061|Bacilli,2Y8ZP@289201|Pontibacillus 91061|Bacilli L 5'-3' exonuclease ypcP - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_880596_1 31964.CMS1687 2.52e-25 108.0 COG1073@1|root,COG1073@2|Bacteria,2GNDJ@201174|Actinobacteria 201174|Actinobacteria Q Belongs to the glycosyl hydrolase family 6 - - 3.1.1.101 ko:K21104 - - R11540 - ko00000,ko01000 - - - Abhydrolase_5,CBM_2,DLH,Hydrolase_4,PAF-AH_p_II,Ricin_B_lectin k59_487735_1 187272.Mlg_1963 7.73e-132 383.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_748761_2 666681.M301_0074 2.22e-43 149.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria,2KMIV@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM response regulator receiver - - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_947283_1 1249627.D779_1826 1.28e-78 259.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_880604_1 1454004.AW11_00972 3.97e-51 185.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,1KQ8R@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_748773_1 929558.SMGD1_0552 1e-52 176.0 COG0169@1|root,COG0169@2|Bacteria,1Q1X7@1224|Proteobacteria,431CA@68525|delta/epsilon subdivisions,2YSA4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) - - - - - - - - - - - - Shikimate_dh_N k59_880605_1 765911.Thivi_3111 1.6e-105 311.0 COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_880605_2 1123401.JHYQ01000007_gene510 4.05e-28 107.0 COG1150@1|root,COG1150@2|Bacteria,1RHH3@1224|Proteobacteria,1S0VG@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_8 k59_260018_1 1441629.PCH70_33100 4.37e-46 165.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1Z4ZS@136849|Pseudomonas syringae group 1236|Gammaproteobacteria O Cytochrome c-type biogenesis protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_686440_1 338963.Pcar_1181 6.8e-53 189.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1PFBZ@1224|Proteobacteria,439XJ@68525|delta/epsilon subdivisions,2X1UU@28221|Deltaproteobacteria,43VBR@69541|Desulfuromonadales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc k59_291181_1 1131553.JIBI01000011_gene741 4.32e-98 295.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,371MG@32003|Nitrosomonadales 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_913559_1 1122963.AUHB01000004_gene2953 1.31e-52 168.0 COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2U7A4@28211|Alphaproteobacteria,36YA2@31993|Methylocystaceae 28211|Alphaproteobacteria L NUDIX domain mutT GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - Acetyltransf_3,NUDIX,NUDIX_4 k59_847916_1 387093.SUN_0553 2.01e-41 144.0 COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2YN1Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_847916_2 387093.SUN_0554 8.55e-74 237.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2YN57@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_686444_1 1442598.JABW01000025_gene1053 6.38e-75 241.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2YMQT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the peptidase S1C family htrA - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_129858_1 1408473.JHXO01000006_gene1209 4.04e-98 307.0 COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,2FWMX@200643|Bacteroidia 976|Bacteroidetes E Amino acid permease - - - - - - - - - - - - AA_permease k59_457182_1 1286106.MPL1_05679 8.16e-97 311.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,45ZWT@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_979212_1 1123326.JFBL01000011_gene222 1.19e-71 239.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YM9E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL,Patched k59_1012008_1 1249975.JQLP01000005_gene1676 8.55e-25 102.0 COG1357@1|root,COG1357@2|Bacteria,4NQ3B@976|Bacteroidetes,1I2VH@117743|Flavobacteriia,2P6XE@244698|Gillisia 976|Bacteroidetes S Pentapeptide repeats (9 copies) - - - - - - - - - - - - Pentapeptide,Pentapeptide_4 k59_587791_1 1095769.CAHF01000010_gene1133 4.16e-50 177.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4735B@75682|Oxalobacteraceae 28216|Betaproteobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_590320_1 1198232.CYCME_0386 1.94e-295 821.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNNJ@1236|Gammaproteobacteria,4607G@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_655897_1 1121937.AUHJ01000002_gene3617 1.97e-84 270.0 COG1520@1|root,COG1520@2|Bacteria,1QU2U@1224|Proteobacteria,1S1NX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Dehydrogenase - - 1.1.2.6 ko:K05889 - - R03136 - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3 k59_426707_1 1168034.FH5T_17585 3.64e-116 354.0 COG2304@1|root,COG2304@2|Bacteria,4NER3@976|Bacteroidetes,2FW70@200643|Bacteroidia 976|Bacteroidetes S oxidoreductase activity - - - - - - - - - - - - - k59_753593_1 1165841.SULAR_07955 2.03e-94 278.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,42NSE@68525|delta/epsilon subdivisions,2YMUG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_753593_2 387093.SUN_2335 1.43e-76 229.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2YT0H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_296075_1 990073.ATHU01000001_gene683 4.23e-48 164.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2YMQW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_753598_2 387093.SUN_0919 0.000136 43.9 COG0607@1|root,COG0607@2|Bacteria,1PEYP@1224|Proteobacteria,42WCJ@68525|delta/epsilon subdivisions,2YQA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_852010_1 1165841.SULAR_02513 1.88e-48 171.0 COG0834@1|root,COG1073@1|root,COG0834@2|Bacteria,COG1073@2|Bacteria,1N3ZN@1224|Proteobacteria,42VWV@68525|delta/epsilon subdivisions 1224|Proteobacteria ET Cache domain - - - - - - - - - - - - dCache_1 k59_1453_1 1168034.FH5T_15105 1.04e-54 179.0 COG2968@1|root,COG2968@2|Bacteria,4NZP7@976|Bacteroidetes,2FZYM@200643|Bacteroidia 976|Bacteroidetes S Protein of unknown function (DUF541) - - - ko:K09807 - - - - ko00000 - - - SIMPL k59_1015189_1 1249627.D779_3877 4.62e-45 155.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales 135613|Chromatiales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_557896_1 1168034.FH5T_19360 7.16e-82 257.0 COG5476@1|root,COG5476@2|Bacteria,4NG23@976|Bacteroidetes,2FQI1@200643|Bacteroidia 976|Bacteroidetes S MlrC C-terminus - - - - - - - - - - - - DUF1485,MlrC_C k59_459734_1 1249480.B649_05480 1.07e-67 213.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - ko:K11005 - - - - ko00000,ko02000,ko02042 1.C.11 - - CBM60,He_PIG,HemolysinCabind,VCBS k59_394221_1 1453501.JELR01000002_gene992 6.18e-17 79.7 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,4644I@72275|Alteromonadaceae 1236|Gammaproteobacteria E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_394221_2 765914.ThisiDRAFT_1910 3.3e-46 156.0 COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria,1WXG2@135613|Chromatiales 135613|Chromatiales V (ABC) transporter - - - - - - - - - - - - - k59_721106_2 388399.SSE37_23354 1.82e-05 44.7 COG3832@1|root,COG3832@2|Bacteria,1RDAM@1224|Proteobacteria,2U5ZG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_459739_1 1250232.JQNJ01000001_gene1730 1.21e-20 94.0 COG1368@1|root,COG1368@2|Bacteria,4NFI9@976|Bacteroidetes,1HYR3@117743|Flavobacteriia 976|Bacteroidetes M sulfatase - - - - - - - - - - - - Sulfatase k59_655931_1 1150600.ADIARSV_1088 4.6e-92 289.0 COG3589@1|root,COG3589@2|Bacteria,4NE7B@976|Bacteroidetes,1IP2A@117747|Sphingobacteriia 976|Bacteroidetes S PFAM glycoside hydrolase - - - - - - - - - - - - GH97_C,GH97_N,Glyco_hydro_97 k59_34378_1 1341181.FLJC2902T_31800 2.83e-96 296.0 COG2826@1|root,COG2826@2|Bacteria,4NJ3V@976|Bacteroidetes,1I1RU@117743|Flavobacteriia,2NX83@237|Flavobacterium 976|Bacteroidetes L Helix-turn-helix domain - - - - - - - - - - - - HTH_38,rve k59_328995_1 1121013.P873_12760 2.67e-97 308.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X486@135614|Xanthomonadales 135614|Xanthomonadales I 3-hydroxyacyl-coa dehydrogenase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_67148_1 1122931.AUAE01000018_gene3893 1.22e-25 104.0 COG0491@1|root,COG0491@2|Bacteria,4NE98@976|Bacteroidetes,2FQYG@200643|Bacteroidia,22XR4@171551|Porphyromonadaceae 976|Bacteroidetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_67148_2 1313421.JHBV01000033_gene2408 1.33e-10 60.8 COG0773@1|root,COG0773@2|Bacteria,4NF99@976|Bacteroidetes,1IPU5@117747|Sphingobacteriia 976|Bacteroidetes M Mur ligase middle domain mpl - 6.3.2.45,6.3.2.8 ko:K01924,ko:K02558 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1466_1 1168034.FH5T_04015 3.3e-40 148.0 COG4797@1|root,COG4797@2|Bacteria,4PKQS@976|Bacteroidetes,2FP69@200643|Bacteroidia 976|Bacteroidetes S Motility related/secretion protein sprA - - - - - - - - - - - SprA_N k59_1466_2 983544.Lacal_1376 1.76e-26 103.0 COG0632@1|root,COG0632@2|Bacteria,4NF4E@976|Bacteroidetes,1HX6W@117743|Flavobacteriia 976|Bacteroidetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_198011_1 572544.Ilyop_0014 2.58e-212 595.0 COG1760@1|root,COG1760@2|Bacteria,3796I@32066|Fusobacteria 32066|Fusobacteria E Serine dehydratase alpha chain - - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_198011_2 572544.Ilyop_0955 3.34e-17 74.3 COG2345@1|root,COG2345@2|Bacteria,37CNP@32066|Fusobacteria 32066|Fusobacteria K HTH domain - - - - - - - - - - - - HTH_11 k59_198011_3 572544.Ilyop_0090 5.87e-64 197.0 COG3576@1|root,COG3576@2|Bacteria,37ANC@32066|Fusobacteria 32066|Fusobacteria S Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx k59_198011_4 572544.Ilyop_0089 1.88e-77 234.0 COG1959@1|root,COG1959@2|Bacteria,37ATZ@32066|Fusobacteria 32066|Fusobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_198011_6 1174504.AJTN02000245_gene3689 5.32e-77 234.0 COG0693@1|root,COG0693@2|Bacteria,1V1CG@1239|Firmicutes,4HFRX@91061|Bacilli,1ZEFQ@1386|Bacillus 91061|Bacilli S DJ-1/PfpI family yraA - 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_198011_7 861452.HMPREF9093_00779 4.55e-78 242.0 COG0652@1|root,COG0652@2|Bacteria,3784E@32066|Fusobacteria 32066|Fusobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K01802,ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_198011_11 1278306.KB906916_gene1142 1.69e-59 188.0 COG1490@1|root,COG1490@2|Bacteria,37A5U@32066|Fusobacteria 32066|Fusobacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_198011_12 469616.FMAG_01197 1.38e-247 693.0 COG1488@1|root,COG1488@2|Bacteria,378M8@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase k59_198011_13 443254.Marpi_2074 7.58e-188 534.0 COG4277@1|root,COG4277@2|Bacteria,2GCI4@200918|Thermotogae 200918|Thermotogae L Helix-hairpin-helix DNA-binding motif class 1 - - - - - - - - - - - - - k59_198011_14 290402.Cbei_4424 8.35e-29 116.0 COG1573@1|root,COG1573@2|Bacteria,1UY78@1239|Firmicutes,24FDP@186801|Clostridia,36H0M@31979|Clostridiaceae 186801|Clostridia L Domain of unknown function (DUF4130 - - - - - - - - - - - - DUF4130 k59_198011_16 469617.FUAG_02120 7.5e-131 390.0 COG1242@1|root,COG1737@1|root,COG1242@2|Bacteria,COG1737@2|Bacteria,3796S@32066|Fusobacteria 32066|Fusobacteria K Radical_SAM C-terminal domain - - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_492336_1 945713.IALB_2311 2.44e-19 92.0 COG1409@1|root,COG2382@1|root,COG2885@1|root,COG1409@2|Bacteria,COG2382@2|Bacteria,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - 3.1.4.53,5.2.1.8 ko:K03651,ko:K03771,ko:K07017 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000,ko03110 - - - DUF3575,Esterase,Metallophos,OmpA,PD40,Rotamase,Rotamase_3 k59_34382_1 1121875.KB907549_gene1803 1.44e-08 61.6 29SSC@1|root,30DYA@2|Bacteria,4NM51@976|Bacteroidetes,1I24J@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF3822) - - - - - - - - - - - - DUF3822 k59_34382_2 1168034.FH5T_16735 1.76e-19 83.6 2C0G9@1|root,310GM@2|Bacteria,4NHU0@976|Bacteroidetes,2FN0C@200643|Bacteroidia 976|Bacteroidetes S COG NOG19144 non supervised orthologous group - - - - - - - - - - - - - k59_917419_1 1116472.MGMO_5c00100 1.05e-17 85.1 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1XDJP@135618|Methylococcales 135618|Methylococcales S PFAM Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_950001_1 1165841.SULAR_00100 8.97e-108 329.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MA6@68525|delta/epsilon subdivisions,2YMMG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V COG0841 Cation multidrug efflux pump - - - - - - - - - - - - ACR_tran k59_623026_1 1384054.N790_08995 4.63e-62 213.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X486@135614|Xanthomonadales 135614|Xanthomonadales I 3-hydroxyacyl-coa dehydrogenase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_198018_1 1165841.SULAR_09219 1.72e-77 239.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2YMHX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Membrane protease subunits - - - - - - - - - - - - Band_7 k59_394244_1 880071.Fleli_1696 5.85e-15 74.3 COG2062@1|root,COG2062@2|Bacteria,4NQFM@976|Bacteroidetes,47R7I@768503|Cytophagia 976|Bacteroidetes T PFAM Phosphoglycerate mutase sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_394244_2 929558.SMGD1_1614 1.53e-101 301.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2YN3F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_753643_2 1123393.KB891316_gene1234 4e-71 224.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI7D@28216|Betaproteobacteria,1KSY5@119069|Hydrogenophilales 119069|Hydrogenophilales C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_459766_1 765912.Thimo_0243 6.48e-144 423.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WZYZ@135613|Chromatiales 135613|Chromatiales C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_198024_1 15368.BRADI1G05758.1 2.29e-96 281.0 COG1290@1|root,KOG4663@2759|Eukaryota,37NKU@33090|Viridiplantae,3G85T@35493|Streptophyta,3KZB0@4447|Liliopsida,3IH6E@38820|Poales 35493|Streptophyta C Cytochrome b6-f complex subunit 4 petD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0016020,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 - ko:K02637 ko00195,ko01100,map00195,map01100 M00162 - - ko00000,ko00001,ko00002,ko00194 - - - Cytochrom_B_C k59_198024_2 4155.Migut.D01434.1.p 5.97e-20 87.4 COG0202@1|root,2QRS7@2759|Eukaryota,37QVG@33090|Viridiplantae,3GHDB@35493|Streptophyta,44N87@71274|asterids 35493|Streptophyta K Bacterial RNA polymerase, alpha chain C terminal domain rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009507,GO:0009532,GO:0009534,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0031976,GO:0031984,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_819642_1 572544.Ilyop_1669 9.05e-40 148.0 COG0557@1|root,COG0557@2|Bacteria,3783U@32066|Fusobacteria 32066|Fusobacteria K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB k59_819642_2 309801.trd_A0358 3.65e-15 75.5 COG0554@1|root,COG0554@2|Bacteria,2G5TV@200795|Chloroflexi,27XT1@189775|Thermomicrobia 189775|Thermomicrobia H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_296601_1 387093.SUN_1957 1.19e-33 127.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2YMPK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_231411_1 292415.Tbd_1452 5.45e-111 325.0 COG3271@1|root,COG3271@2|Bacteria,1RAD5@1224|Proteobacteria,2VIY6@28216|Betaproteobacteria,1KSUV@119069|Hydrogenophilales 119069|Hydrogenophilales - - - - - - - - - - - - - - - k59_623522_1 391615.ABSJ01000054_gene1377 7.22e-94 288.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1J8US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_754065_1 1168034.FH5T_07940 3.94e-163 468.0 COG0635@1|root,COG0635@2|Bacteria,4NEY5@976|Bacteroidetes,2FMT8@200643|Bacteroidia 976|Bacteroidetes H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN - - - - - - - - - - - HemN_C,Radical_SAM k59_558360_1 887898.HMPREF0551_1901 1.29e-74 230.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,1K065@119060|Burkholderiaceae 28216|Betaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_558360_2 469610.HMPREF0189_00100 1.53e-43 144.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2VSE6@28216|Betaproteobacteria,1KM24@119065|unclassified Burkholderiales 28216|Betaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_918011_2 1403313.AXBR01000002_gene4159 4.79e-12 67.0 COG0745@1|root,COG0745@2|Bacteria,1TPRM@1239|Firmicutes,4HAMG@91061|Bacilli,1ZQ5Q@1386|Bacillus 91061|Bacilli T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_198526_2 1384054.N790_10990 1.82e-08 55.8 COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,1SHAC@1236|Gammaproteobacteria,1X3IB@135614|Xanthomonadales 135614|Xanthomonadales S Dak2 - - - ko:K07030 - - - - ko00000 - - - Dak2,DegV k59_590818_1 572477.Alvin_0342 4.37e-06 53.9 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1WWQS@135613|Chromatiales 135613|Chromatiales Q PFAM Mammalian cell entry related - - - ko:K06192 - - - - ko00000 - - - MlaD k59_362288_1 593907.Celgi_1292 1.23e-22 101.0 COG1196@1|root,COG4913@1|root,COG5283@1|root,COG1196@2|Bacteria,COG4913@2|Bacteria,COG5283@2|Bacteria,2I92I@201174|Actinobacteria 201174|Actinobacteria M Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail k59_492839_1 626522.GCWU000325_01652 2.94e-10 67.0 COG4974@1|root,COG4974@2|Bacteria,4NX3Q@976|Bacteroidetes,2G3F8@200643|Bacteroidia,1WD70@1283313|Alloprevotella 976|Bacteroidetes L Arm DNA-binding domain - - - - - - - - - - - - Arm-DNA-bind_5,Phage_int_SAM_5,Phage_integrase k59_623530_1 211165.AJLN01000149_gene6654 7.33e-23 102.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1JI65@1189|Stigonemataceae 1117|Cyanobacteria Q Condensation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,TPR_1,TPR_8,Thioesterase k59_133399_1 266748.HY04_02455 7.55e-20 81.6 COG0607@1|root,30PYW@2|Bacteria,4PGX0@976|Bacteroidetes,1IKHT@117743|Flavobacteriia,3ZU5B@59732|Chryseobacterium 976|Bacteroidetes P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_133399_2 314278.NB231_04485 8.51e-11 62.4 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales 135613|Chromatiales S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_819652_1 298386.PBPRB0472 3.53e-99 299.0 COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,1RNTS@1236|Gammaproteobacteria,1XTC8@135623|Vibrionales 135623|Vibrionales G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10440,ko:K17214 ko02010,map02010 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 k59_852606_1 1165841.SULAR_07935 1.08e-14 72.8 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2YMUV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_852606_2 563040.Saut_0233 3e-51 166.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,42SRC@68525|delta/epsilon subdivisions,2YP4I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_852606_3 1121468.AUBR01000044_gene1844 5.14e-15 71.2 COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,42G80@68295|Thermoanaerobacterales 186801|Clostridia J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_623545_1 977880.RALTA_A3092 4.37e-24 100.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1K2Y1@119060|Burkholderiaceae 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1015717_1 880072.Desac_0705 1.98e-40 137.0 COG0745@1|root,COG0745@2|Bacteria,1MZI2@1224|Proteobacteria,42TWU@68525|delta/epsilon subdivisions,2WQ3Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_1015717_2 1378168.N510_00766 1.73e-10 62.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria 2|Bacteria T PhoQ Sensor - - - - - - - - - - - - HATPase_c,HDOD,HisKA,Response_reg,dCache_1 k59_786995_1 1218352.B597_010420 2.35e-84 259.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1YZT0@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily adhC - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_786995_2 103690.17131901 2.55e-52 174.0 COG0627@1|root,COG0627@2|Bacteria,1G1D6@1117|Cyanobacteria,1HIZJ@1161|Nostocales 1117|Cyanobacteria S Serine hydrolase involved in the detoxification of formaldehyde - - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase k59_721706_1 1284352.AOIG01000021_gene3894 5.07e-07 56.6 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V4UB@1239|Firmicutes,4HDDC@91061|Bacilli,26QY9@186822|Paenibacillaceae 91061|Bacilli T Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg k59_1824_1 313595.P700755_002944 4.03e-29 113.0 COG2957@1|root,COG2957@2|Bacteria,4NGF8@976|Bacteroidetes,1HYT2@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the agmatine deiminase family - - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_36463_1 944547.ABLL_2273 2.55e-109 322.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2YMU9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_788617_1 1323663.AROI01000011_gene3247 2.25e-31 122.0 COG1502@1|root,COG1502@2|Bacteria 2|Bacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - - - - - - - - - - PLDc_2 k59_952144_1 360107.CHAB381_1436 7.67e-14 77.4 2AJBX@1|root,319X7@2|Bacteria,1Q4BG@1224|Proteobacteria,42YT4@68525|delta/epsilon subdivisions,2YRDM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_102594_1 1123504.JQKD01000027_gene4088 5.16e-107 316.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2VIUC@28216|Betaproteobacteria,4AC4C@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM 2-nitropropane dioxygenase NPD - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_462345_1 1168034.FH5T_06445 8.56e-217 613.0 COG0513@1|root,COG0513@2|Bacteria,4NEJV@976|Bacteroidetes,2FMB6@200643|Bacteroidia 976|Bacteroidetes L Belongs to the DEAD box helicase family deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_625231_1 1165841.SULAR_08427 1.72e-25 102.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2YMNC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_625231_2 387093.SUN_2361 4.55e-134 395.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,42MG1@68525|delta/epsilon subdivisions,2YN29@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E amino acid carrier protein - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_2844_1 470145.BACCOP_02870 2.5e-233 672.0 COG1327@1|root,COG1328@1|root,COG1327@2|Bacteria,COG1328@2|Bacteria,4NGPS@976|Bacteroidetes,2FNK4@200643|Bacteroidia,4AKV3@815|Bacteroidaceae 976|Bacteroidetes FK Psort location Cytoplasmic, score 8.96 nrdD - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,NRDD k59_1017466_1 880073.Calab_3293 3.81e-28 117.0 COG3829@1|root,COG3829@2|Bacteria,2NQNU@2323|unclassified Bacteria 2|Bacteria KT Sigma-54 interaction domain - - - - - - - - - - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_658445_2 1319815.HMPREF0202_00094 4.76e-116 338.0 COG1192@1|root,COG1192@2|Bacteria 2|Bacteria D plasmid maintenance - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_658445_3 1319815.HMPREF0202_02271 3.79e-23 100.0 2EFRP@1|root,339HP@2|Bacteria,37B3E@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_396530_1 857087.Metme_0903 2.18e-12 69.7 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XE8Y@135618|Methylococcales 135618|Methylococcales NU PFAM Type II secretion system protein E - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_788627_1 1121324.CLIT_18c00290 8.04e-75 242.0 COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,25QFM@186804|Peptostreptococcaceae 186801|Clostridia M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_331421_1 1207055.C100_05990 1.51e-60 196.0 COG1309@1|root,COG1309@2|Bacteria,1MY9K@1224|Proteobacteria,2U3PH@28211|Alphaproteobacteria,2K44A@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - - - - - - - - - - TetR_N k59_1017472_1 1168034.FH5T_10525 1.22e-86 273.0 COG1884@1|root,COG1884@2|Bacteria,4NDVE@976|Bacteroidetes,2FM0R@200643|Bacteroidia 976|Bacteroidetes I Methylmalonyl-CoA mutase mutA - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_854123_1 526218.Sterm_2663 1.14e-106 323.0 COG0044@1|root,COG0044@2|Bacteria,379AR@32066|Fusobacteria 32066|Fusobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_854123_2 1408439.JHXW01000003_gene1504 6.2e-94 280.0 COG0461@1|root,COG0461@2|Bacteria,3790D@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_690642_1 765911.Thivi_2320 1.09e-116 347.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1WWCK@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_69452_1 3702.ATCG01050.1 1.52e-175 502.0 COG1008@1|root,KOG4845@2759|Eukaryota,37QQT@33090|Viridiplantae,3G7MJ@35493|Streptophyta 35493|Streptophyta C NAD(P)H-quinone oxidoreductase chain ndhD - 1.6.5.3 ko:K05575 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Proton_antipo_M k59_658454_1 1452718.JBOY01000161_gene2110 9.94e-26 109.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria 1236|Gammaproteobacteria U COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_821447_1 1158146.KB907131_gene1365 7.25e-68 214.0 COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,1RPII@1236|Gammaproteobacteria,1WVYZ@135613|Chromatiales 135613|Chromatiales G TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - - - - - - - - - - HAD_2 k59_788634_1 572544.Ilyop_0361 8e-137 415.0 COG0013@1|root,COG0013@2|Bacteria,378SD@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_265310_1 1168034.FH5T_10055 1.82e-107 320.0 COG4992@1|root,COG4992@2|Bacteria,4NE0Z@976|Bacteroidetes,2FNR5@200643|Bacteroidia 976|Bacteroidetes E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_462363_1 102129.Lepto7375DRAFT_0848 8.87e-07 56.6 COG2304@1|root,COG3291@1|root,COG2304@2|Bacteria,COG3291@2|Bacteria,1GQN0@1117|Cyanobacteria 1117|Cyanobacteria S Domain of unknown function (DUF4114) - - - - - - - - - - - - DUF4114 k59_298100_1 396588.Tgr7_1069 2.28e-34 126.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales 135613|Chromatiales S PFAM Radical SAM - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_233113_1 1163617.SCD_n02699 4.6e-34 128.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria 28216|Betaproteobacteria D peptidase envC - - - - - - - - - - - Peptidase_M23 k59_69464_1 331869.BAL199_18816 5.9e-99 307.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,4BRG0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 k59_363798_1 768066.HELO_2225 8.97e-26 106.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1XIFP@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase III holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta,DNA_pol3_gamma3 k59_363798_2 378806.STAUR_6690 3.76e-89 271.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,42P6R@68525|delta/epsilon subdivisions,2WKXS@28221|Deltaproteobacteria,2YUES@29|Myxococcales 28221|Deltaproteobacteria E Belongs to the peptidase S33 family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_429273_1 572544.Ilyop_0480 7.6e-28 102.0 COG0864@1|root,COG0864@2|Bacteria,37B51@32066|Fusobacteria 32066|Fusobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_429273_2 293826.Amet_2058 3.34e-20 94.4 COG0741@1|root,COG5010@1|root,COG0741@2|Bacteria,COG5010@2|Bacteria,1V6DD@1239|Firmicutes,24JDA@186801|Clostridia,36FCA@31979|Clostridiaceae 186801|Clostridia M transglycosylase yjbJ - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT k59_560975_2 485915.Dret_1750 5.34e-56 195.0 COG0021@1|root,COG0021@2|Bacteria 2|Bacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_N,XFP,XFP_N k59_168877_1 1355374.JARU01000002_gene1122 2.13e-73 245.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YM7R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Efflux pump membrane transporter - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_168877_2 556267.HWAG_00009 8.54e-13 73.6 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2YMT9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU RND efflux system, outer membrane lipoprotein cmeC - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_397150_2 882083.SacmaDRAFT_5112 2.11e-53 184.0 COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4DYW0@85010|Pseudonocardiales 201174|Actinobacteria J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_528269_1 387093.SUN_1362 4.29e-133 388.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2YN1A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase aspB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_528269_2 1165841.SULAR_00835 3.27e-48 159.0 COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,42RIW@68525|delta/epsilon subdivisions,2YP6Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane-associated protein dedA - - - - - - - - - - - SNARE_assoc k59_691265_1 240292.Ava_4081 5.92e-56 181.0 COG0412@1|root,COG0412@2|Bacteria,1G4DJ@1117|Cyanobacteria,1HNFI@1161|Nostocales 1117|Cyanobacteria Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_691265_2 631454.N177_1748 2.52e-22 93.2 COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2U5HS@28211|Alphaproteobacteria,1JQ20@119043|Rhodobiaceae 28211|Alphaproteobacteria S Phosphoribosyl transferase domain - - - ko:K07100 - - - - ko00000 - - - Erythro_esteras,Pribosyltran k59_463037_1 1319815.HMPREF0202_00780 4.5e-187 535.0 COG0213@1|root,COG0213@2|Bacteria,379K2@32066|Fusobacteria 32066|Fusobacteria F pyrimidine-nucleoside phosphorylase pyn - 2.4.2.2 ko:K00756 ko00240,ko01100,map00240,map01100 - R01570,R01876,R02296,R02484 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_463037_2 572544.Ilyop_0430 3.71e-131 379.0 COG0005@1|root,COG0005@2|Bacteria,378R8@32066|Fusobacteria 32066|Fusobacteria F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate - - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_463037_3 1304284.L21TH_1794 1.77e-40 143.0 COG2059@1|root,COG2059@2|Bacteria,1V43H@1239|Firmicutes,24JTX@186801|Clostridia,36IGJ@31979|Clostridiaceae 186801|Clostridia P Chromate transport protein - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_463037_4 1121335.Clst_0706 6.31e-39 143.0 COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,3WJYR@541000|Ruminococcaceae 186801|Clostridia P Psort location CytoplasmicMembrane, score chrA2 - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_463037_6 1280679.ATVX01000002_gene713 1.43e-75 253.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,4BW53@830|Butyrivibrio 186801|Clostridia T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_463037_7 469618.FVAG_00150 8.38e-91 273.0 COG0745@1|root,COG0745@2|Bacteria,379HE@32066|Fusobacteria 32066|Fusobacteria K Psort location Cytoplasmic, score 9.97 - - - - - - - - - - - - Response_reg,Trans_reg_C k59_463037_8 1499684.CCNP01000018_gene997 1.27e-30 112.0 COG0346@1|root,COG0346@2|Bacteria,1V6K3@1239|Firmicutes,24J94@186801|Clostridia,36IQK@31979|Clostridiaceae 186801|Clostridia E PFAM Glyoxalase bleomycin resistance protein dioxygenase gloA - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_463037_9 999425.HMPREF9186_00649 1.32e-33 134.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4HATE@91061|Bacilli 91061|Bacilli V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_625900_1 1537917.JU82_06600 3.79e-67 206.0 COG2346@1|root,COG2346@2|Bacteria,1Q5UZ@1224|Proteobacteria,42U39@68525|delta/epsilon subdivisions,2YPTS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG2346 Truncated hemoglobins - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_625900_2 1408442.JADE01000004_gene139 2.29e-21 90.9 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2YMGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_756160_1 929558.SMGD1_2551 1.38e-77 244.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,42MQU@68525|delta/epsilon subdivisions,2YMC7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q TRAP transporter, DctM subunit - - - - - - - - - - - - DctM,DctQ k59_332102_1 715226.ABI_27960 5.57e-74 237.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0277 FAD FMN-containing dehydrogenases dld GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.1.1.303,1.1.1.4,1.1.2.4 ko:K00004,ko:K00102 ko00620,ko00650,map00620,map00650 - R00197,R02855,R02946,R10504 RC00044,RC00205,RC00525 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_985324_2 323261.Noc_1656 3.89e-08 54.3 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria,1X2EF@135613|Chromatiales 135613|Chromatiales E PFAM aminotransferase class V - - - - - - - - - - - - Aminotran_5 k59_822142_1 1165841.SULAR_08567 1.76e-95 291.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,42P59@68525|delta/epsilon subdivisions,2YMPJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0324 family - - - - - - - - - - - - Cons_hypoth698 k59_789259_1 935863.AWZR01000003_gene2624 3.06e-104 315.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1X2ZK@135614|Xanthomonadales 135614|Xanthomonadales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_168898_1 1121396.KB893068_gene1454 2.67e-95 289.0 COG1466@1|root,COG1466@2|Bacteria,1RAEB@1224|Proteobacteria,42R0X@68525|delta/epsilon subdivisions,2WMQJ@28221|Deltaproteobacteria,2MJNX@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III, delta' holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta k59_886811_1 1250005.PHEL85_2141 1.25e-103 322.0 COG0243@1|root,COG0243@2|Bacteria,4PIKC@976|Bacteroidetes,1ICDV@117743|Flavobacteriia,3VXCJ@52959|Polaribacter 976|Bacteroidetes C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_625915_1 1185766.DL1_04525 3.74e-73 231.0 COG0738@1|root,COG0738@2|Bacteria,1QUEB@1224|Proteobacteria,2TW8G@28211|Alphaproteobacteria,2XMTS@285107|Thioclava 28211|Alphaproteobacteria G Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_920607_1 237368.SCABRO_01212 9.4e-60 209.0 COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,2IX0B@203682|Planctomycetes 203682|Planctomycetes MU outer membrane lipoprotein IbeB - - - - - - - - - - - - OEP k59_756166_1 3880.AES97352 3.7e-18 82.4 KOG4853@1|root,KOG4853@2759|Eukaryota,37UN2@33090|Viridiplantae,3GJA7@35493|Streptophyta 35493|Streptophyta S mitotic sister chromatid biorientation - - - - - - - - - - - - - k59_756166_2 981085.XP_010106598.1 1.8e-29 110.0 2E13Y@1|root,2S8GD@2759|Eukaryota,38843@33090|Viridiplantae,3GW79@35493|Streptophyta,4JVE3@91835|fabids 35493|Streptophyta - - - - - - - - - - - - - - - k59_659109_1 1122951.ATUE01000005_gene1656 3.62e-89 283.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,3NIU5@468|Moraxellaceae 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_756167_1 387093.SUN_0445 2.02e-93 281.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2YMIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LU DNA processing protein dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_691292_1 929562.Emtol_3067 3.46e-14 68.6 2DMPT@1|root,32SXV@2|Bacteria,4PKGT@976|Bacteroidetes,47R1K@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF3127) - - - - - - - - - - - - DUF3127 k59_691292_2 273068.TTE1560 5.17e-06 50.8 COG4826@1|root,COG4826@2|Bacteria,1UYKX@1239|Firmicutes,24B76@186801|Clostridia,42IEB@68295|Thermoanaerobacterales 186801|Clostridia O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin k59_70128_1 443144.GM21_0069 1.84e-16 82.4 COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,42PW8@68525|delta/epsilon subdivisions,2WKCT@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM alpha beta hydrolase fold - - 1.11.1.10 ko:K00433 - - - - ko00000,ko01000 - - - Abhydrolase_1,Hydrolase_4 k59_691297_2 745411.B3C1_19133 5.24e-87 270.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,1J7B8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase Z012_08285 - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_463082_2 367737.Abu_1697 8.61e-18 85.1 2AJIG@1|root,31A58@2|Bacteria,1Q4YP@1224|Proteobacteria,4305P@68525|delta/epsilon subdivisions,2YRVQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_70132_1 411460.RUMTOR_01166 1.1e-75 244.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,3XZ2F@572511|Blautia 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_265921_1 1229205.BUPH_03712 5.17e-83 258.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,1K11D@119060|Burkholderiaceae 28216|Betaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_37119_1 743720.Psefu_0374 5e-90 276.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1YV5K@136845|Pseudomonas putida group 1236|Gammaproteobacteria P Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_985364_1 1353537.TP2_00595 3.66e-37 142.0 COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidase, M50 family - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,PqqD k59_397201_1 713587.THITH_06845 2.32e-61 197.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1WX20@135613|Chromatiales 135613|Chromatiales O TIGRFAM hydrogenase expression formation protein HypE - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_397201_2 640081.Dsui_1155 6.57e-16 76.6 COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,2KVS4@206389|Rhodocyclales 206389|Rhodocyclales IJ Formyl transferase, C-terminal domain - - - ko:K19640 - - - - ko00000,ko02022 - - - ECH_1,Formyl_trans_C,Formyl_trans_N k59_953655_1 1249627.D779_3786 5.99e-77 233.0 COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,1S2DE@1236|Gammaproteobacteria,1WY01@135613|Chromatiales 135613|Chromatiales S TIGRFAM TIGR00645 family protein - - - - - - - - - - - - UPF0114 k59_953655_2 882.DVU_2976 1.57e-05 46.6 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2M938@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_365704_1 1220534.B655_0926 5.42e-74 245.0 COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota 28890|Euryarchaeota O COG1331 Highly conserved protein containing a thioredoxin domain - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_823274_1 765914.ThisiDRAFT_0886 8.33e-51 181.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_823274_2 1158150.KB906241_gene1051 4.97e-20 89.4 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1WXGR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus assembly protein PilM - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_855904_1 537007.BLAHAN_04629 1.18e-21 93.6 COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,3XZ4P@572511|Blautia 186801|Clostridia E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_953660_1 1168034.FH5T_06525 8.84e-94 300.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,2FM8X@200643|Bacteroidia 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_724868_1 264198.Reut_A2229 1.91e-106 325.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,1K0R8@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_104472_1 713586.KB900536_gene1640 7.17e-30 122.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales 135613|Chromatiales MU type I secretion outer membrane protein, TolC - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_234786_1 1268239.PALB_29250 1.12e-49 180.0 COG1196@1|root,COG1196@2|Bacteria,1R25H@1224|Proteobacteria,1S41G@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_529543_1 1201290.M902_2111 3.29e-20 87.8 COG0515@1|root,COG0515@2|Bacteria,1NUIB@1224|Proteobacteria 1224|Proteobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_529543_2 765913.ThidrDRAFT_0273 9.56e-44 156.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales 135613|Chromatiales E PFAM Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_953663_1 1122173.AXVL01000020_gene2247 5.64e-243 675.0 COG2723@1|root,COG2723@2|Bacteria,378ZT@32066|Fusobacteria 32066|Fusobacteria G Belongs to the glycosyl hydrolase 1 family - - 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT1 - Glyco_hydro_1 k59_887800_1 720554.Clocl_0048 5.87e-89 276.0 COG2304@1|root,COG2304@2|Bacteria,1V0KR@1239|Firmicutes,24EF5@186801|Clostridia,3WG8T@541000|Ruminococcaceae 186801|Clostridia S von Willebrand factor type A domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_137368_1 563040.Saut_1315 2.43e-59 194.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,43AEH@68525|delta/epsilon subdivisions,2YMAF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_724878_1 998674.ATTE01000001_gene2499 1.45e-69 218.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,4603D@72273|Thiotrichales 72273|Thiotrichales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_593928_1 319224.Sputcn32_2948 8e-123 357.0 COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,1RP20@1236|Gammaproteobacteria,2QB7G@267890|Shewanellaceae 1236|Gammaproteobacteria S Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - - - - - - - - - - DUF2235,PilZ k59_953664_1 1168034.FH5T_10280 3.35e-35 129.0 COG0095@1|root,COG0095@2|Bacteria,4NE5F@976|Bacteroidetes,2FMDJ@200643|Bacteroidia 976|Bacteroidetes H Lipoate-protein ligase lplA - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB,Lip_prot_lig_C k59_757203_1 1168034.FH5T_00160 1.31e-52 174.0 COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,2FR1K@200643|Bacteroidia 976|Bacteroidetes E Asparaginase iaaA - 3.4.19.5 ko:K13051 - - - - ko00000,ko01000,ko01002 - - - Asparaginase_2 k59_757203_2 1168034.FH5T_00165 4.02e-55 189.0 COG1572@1|root,COG1572@2|Bacteria,4PM6M@976|Bacteroidetes,2FXM1@200643|Bacteroidia 976|Bacteroidetes S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA,CARDB k59_3837_1 1168034.FH5T_10725 3.2e-58 188.0 COG0039@1|root,COG0039@2|Bacteria,4NEJ7@976|Bacteroidetes,2FM7E@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_692412_1 1537917.JU82_04050 4.27e-139 403.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2YMJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_496523_1 1379281.AVAG01000026_gene1611 2.97e-77 245.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2M7ZB@213115|Desulfovibrionales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_757212_1 388413.ALPR1_13610 1.17e-65 221.0 COG2010@1|root,COG2010@2|Bacteria,4NEPV@976|Bacteroidetes,47JYA@768503|Cytophagia 976|Bacteroidetes C Planctomycete cytochrome C - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_953670_1 631362.Thi970DRAFT_04077 9.9e-172 504.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_72019_1 335543.Sfum_0256 1.08e-66 222.0 COG2070@1|root,COG2070@2|Bacteria,1R8ZS@1224|Proteobacteria,42N1N@68525|delta/epsilon subdivisions,2WMIF@28221|Deltaproteobacteria 28221|Deltaproteobacteria S 2-Nitropropane dioxygenase - - - - - - - - - - - - - k59_235352_1 177437.HRM2_35970 1.32e-57 191.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria,2MI38@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_627691_1 414684.RC1_0463 2.5e-48 175.0 COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,2TSK9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Outer membrane receptor - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_529976_2 572477.Alvin_3065 4.07e-128 372.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1WW5V@135613|Chromatiales 135613|Chromatiales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_529976_3 523791.Kkor_1730 3.68e-39 135.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,1XJY9@135619|Oceanospirillales 135619|Oceanospirillales E Lactoylglutathione lyase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_529976_4 1036674.A28LD_0613 5.22e-70 217.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,2QFZ4@267893|Idiomarinaceae 1236|Gammaproteobacteria S Bacterial transferase hexapeptide (six repeats) yrdA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840 - - - - - - - - - - Hexapep k59_529976_5 1049564.TevJSym_ak00410 5.17e-96 283.0 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,1J62H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_529976_6 1049564.TevJSym_ak00400 7.44e-78 247.0 COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1J6CD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S E3 Ubiquitin ligase - - - - - - - - - - - - GIDE k59_529976_7 1049564.TevJSym_ak00380 0.0 1008.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1J572@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Oligopeptidase A prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_529976_9 545264.KB898744_gene2276 4.07e-297 817.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_529976_10 1049564.TevJSym_ak00120 5.59e-93 278.0 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria,1J6UB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D AAA domain - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_529976_11 1173028.ANKO01000219_gene470 2.42e-117 371.0 COG5001@1|root,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1H9V4@1150|Oscillatoriales 1117|Cyanobacteria T Diguanylate cyclase - - - - - - - - - - - - CBS,CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_529976_12 879212.DespoDRAFT_00616 4.67e-06 53.9 COG2204@1|root,COG2206@1|root,COG2204@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria,2MHS0@213118|Desulfobacterales 28221|Deltaproteobacteria T HD domain - - - - - - - - - - - - GAF_2,GAF_3,GGDEF,HD,Response_reg k59_529976_13 1167006.UWK_01301 2.62e-91 286.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42R6F@68525|delta/epsilon subdivisions,2WN2B@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - - - - - - - - - - - HD_5,Response_reg k59_529976_14 1121451.DESAM_10152 2.29e-78 254.0 COG1639@1|root,COG2197@1|root,COG1639@2|Bacteria,COG2197@2|Bacteria,1R6YN@1224|Proteobacteria,42Q4G@68525|delta/epsilon subdivisions,2WJM9@28221|Deltaproteobacteria,2M947@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM Metal-dependent hydrolase HDOD - - - - - - - - - - - - HDOD,Response_reg k59_529976_15 1049564.TevJSym_an00100 2.65e-126 385.0 COG3290@1|root,COG4191@1|root,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSDZ@1236|Gammaproteobacteria,1J686@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_529976_16 768671.ThimaDRAFT_4248 1.22e-48 163.0 COG1719@1|root,COG1719@2|Bacteria,1RHJC@1224|Proteobacteria,1S6UH@1236|Gammaproteobacteria,1X2GG@135613|Chromatiales 135613|Chromatiales S Haem-NO-binding - - - - - - - - - - - - HNOB k59_529976_17 765911.Thivi_3870 9.11e-110 326.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales 135613|Chromatiales GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind k59_529976_18 1121035.AUCH01000009_gene846 3.3e-40 155.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,2KVAI@206389|Rhodocyclales 206389|Rhodocyclales H enzyme of heme biosynthesis hemY - - ko:K02498 - - - - ko00000 - - - HemY_N k59_529976_19 1049564.TevJSym_ak00070 2.77e-47 176.0 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1J63W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H enzyme of heme biosynthesis hemX - 2.1.1.107,4.2.1.75 ko:K02496,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iPC815.YPO3851,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317 HemX k59_529976_21 396588.Tgr7_0028 1.29e-50 173.0 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales 135613|Chromatiales H Uroporphyrinogen III synthase - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_529976_22 1049564.TevJSym_ak00050 1.51e-159 453.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1J4EA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iPC815.YPO3849 Porphobil_deam,Porphobil_deamC k59_529976_23 1120977.JHUX01000004_gene2521 8.57e-69 219.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,3NIWF@468|Moraxellaceae 1236|Gammaproteobacteria KT LytTr DNA-binding domain algR - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_529976_24 713586.KB900536_gene2168 1.8e-78 250.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1WYMY@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_529976_25 1249627.D779_3389 2.17e-263 729.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales 135613|Chromatiales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_529976_26 1049564.TevJSym_bb00340 2.5e-46 163.0 COG2199@1|root,COG3706@2|Bacteria,1NE0J@1224|Proteobacteria,1SF4P@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF k59_529976_27 1049564.TevJSym_bb00330 4.98e-280 810.0 COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,1J501@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Adenylate cyclase cyaA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 ko:K05851 ko00230,ko02026,ko05111,map00230,map02026,map05111 - R00089,R00434 RC00295 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365 Adenyl_cycl_N,Adenylate_cycl k59_529976_29 243365.CV_2528 6.55e-117 343.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,2KQ16@206351|Neisseriales 206351|Neisseriales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_529976_30 1049564.TevJSym_at00470 3.73e-55 185.0 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1J612@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yigA - - ko:K09921 - - - - ko00000 - - - DUF484 k59_529976_31 1249627.D779_3723 1.69e-125 368.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1WW4W@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_529976_32 316067.Geob_2188 2.58e-49 161.0 2AAM4@1|root,30ZYM@2|Bacteria,1RGIM@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384 k59_529976_33 269799.Gmet_1661 2.63e-74 231.0 2DMTF@1|root,32TK3@2|Bacteria 2|Bacteria S RES - - - - - - - - - - - - RES k59_529976_34 323261.Noc_0087 6.6e-123 355.0 COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,1WYZ2@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL k59_529976_35 593750.Metfor_0511 5.52e-37 132.0 COG3153@1|root,arCOG00850@2157|Archaea,2Y0NI@28890|Euryarchaeota 28890|Euryarchaeota K Acetyltransferase (GNAT) domain - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_9 k59_105128_1 314287.GB2207_10066 8.18e-20 96.3 COG4774@1|root,COG4774@2|Bacteria,1PIT1@1224|Proteobacteria,1SKRR@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Outer membrane receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_202536_1 572544.Ilyop_1085 8.86e-19 87.0 COG3044@1|root,COG3044@2|Bacteria,3784Y@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - ABC_ATPase k59_202536_2 1319815.HMPREF0202_00368 8.45e-159 454.0 COG1663@1|root,COG1663@2|Bacteria,378S2@32066|Fusobacteria 32066|Fusobacteria M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_823778_1 526222.Desal_3551 3.09e-150 433.0 COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,42NQ9@68525|delta/epsilon subdivisions,2WM2K@28221|Deltaproteobacteria,2M815@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the group II decarboxylase family - - 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_235354_2 396588.Tgr7_0968 2.74e-74 245.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales 135613|Chromatiales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_497160_1 1049564.TevJSym_aa00850 5.32e-38 139.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1J4H6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944 - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_725434_1 1172190.M947_10915 1.05e-39 139.0 COG2204@1|root,COG2204@2|Bacteria,1QUIV@1224|Proteobacteria,42M4N@68525|delta/epsilon subdivisions,2YMIT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_725434_2 1249480.B649_03240 2.05e-42 150.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2YME3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P sulfate adenylyltransferase sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_72044_2 1278309.KB907099_gene2403 2.27e-07 51.2 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,1RNBU@1236|Gammaproteobacteria,1XIMF@135619|Oceanospirillales 135619|Oceanospirillales S metal-binding protein - - - - - - - - - - - - NIF3 k59_398701_1 1168034.FH5T_10215 3.03e-102 303.0 COG3203@1|root,COG3203@2|Bacteria,4NMHJ@976|Bacteroidetes,2FT17@200643|Bacteroidia 976|Bacteroidetes M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_366360_2 1165841.SULAR_03367 5.82e-26 103.0 COG0204@1|root,COG0204@2|Bacteria,1NCW0@1224|Proteobacteria,42SG7@68525|delta/epsilon subdivisions,2YPE4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_856498_1 553218.CAMRE0001_1254 2.62e-39 140.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N5U@68525|delta/epsilon subdivisions,2YMNF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_856498_2 536227.CcarbDRAFT_0155 4.29e-11 64.3 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36EAA@31979|Clostridiaceae 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.30 ko:K02010,ko:K02052 ko02010,ko02024,map02010,map02024 M00190,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11 - - ABC_tran,TOBE_2 k59_987174_1 28564.XP_002483185.1 2.92e-08 55.8 COG0473@1|root,KOG0785@2759|Eukaryota,38B8U@33154|Opisthokonta,3NV1E@4751|Fungi,3QNKE@4890|Ascomycota,20FVM@147545|Eurotiomycetes,3S8EC@5042|Eurotiales 4751|Fungi E tartrate dehydrogenase - - - ko:K10862 - - - - ko00000,ko01000,ko03400 - - - Iso_dh k59_987174_2 1443125.Z962_08860 7.05e-204 578.0 COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,36DHF@31979|Clostridiaceae 186801|Clostridia C citrate synthase gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_987174_3 402880.MmarC5_1141 5.11e-41 142.0 COG0778@1|root,arCOG00288@2157|Archaea,2XYGC@28890|Euryarchaeota,23QVS@183939|Methanococci 28890|Euryarchaeota C PFAM nitroreductase - - - - - - - - - - - - Nitroreductase,TM1586_NiRdase k59_987174_4 1033737.CAEV01000061_gene2888 1.17e-16 72.8 COG2345@1|root,COG2345@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - HTH_11,HTH_20,HTH_IclR,MarR_2,ThiS k59_366363_1 335283.Neut_0807 3.67e-57 193.0 28K6U@1|root,2Z9V7@2|Bacteria,1MYVN@1224|Proteobacteria,2VNQ9@28216|Betaproteobacteria 28216|Betaproteobacteria S Carboxysome Shell Carbonic Anhydrase - - - - - - - - - - - - CsoSCA k59_38432_1 338969.Rfer_1608 4.45e-37 128.0 COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2VV7D@28216|Betaproteobacteria,4AF57@80864|Comamonadaceae 28216|Betaproteobacteria S Predicted integral membrane protein (DUF2282) - - - - - - - - - - - - DUF2282 k59_38432_2 768671.ThimaDRAFT_4835 2.8e-80 243.0 COG1595@1|root,COG1595@2|Bacteria,1MVS7@1224|Proteobacteria,1S9FF@1236|Gammaproteobacteria,1WZCY@135613|Chromatiales 135613|Chromatiales K sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_497169_1 572544.Ilyop_1176 3.03e-185 518.0 COG3129@1|root,COG3129@2|Bacteria,37BW7@32066|Fusobacteria 32066|Fusobacteria J Specifically methylates the adenine in position 1618 of 23S rRNA - - 2.1.1.181 ko:K06970 - - R07232 RC00003,RC00335 ko00000,ko01000,ko03009 - - - Methyltransf_10 k59_170616_1 563040.Saut_0916 6.44e-45 161.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2YMAI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_170616_2 1249480.B649_07690 1.02e-56 184.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2YMC0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_529997_1 713587.THITH_13570 7.02e-58 187.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1WZWK@135613|Chromatiales 135613|Chromatiales G pfkB family carbohydrate kinase - - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_105155_1 1168034.FH5T_14450 5.25e-125 361.0 COG0247@1|root,COG0247@2|Bacteria,4NIMP@976|Bacteroidetes,2FN40@200643|Bacteroidia 976|Bacteroidetes C Cysteine-rich domain protein - - - ko:K18928 - - - - ko00000 - - - CCG k59_627723_1 626887.J057_22555 6.89e-62 200.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,465AH@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_627723_2 1123073.KB899244_gene313 1.05e-22 97.4 COG2271@1|root,COG2271@2|Bacteria,1QZ70@1224|Proteobacteria 1224|Proteobacteria G Major Facilitator - - - - - - - - - - - - MFS_1 k59_1019855_1 572544.Ilyop_0186 9.12e-145 427.0 COG3808@1|root,COG3808@2|Bacteria,3795I@32066|Fusobacteria 32066|Fusobacteria C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1019855_2 572544.Ilyop_0187 8.85e-234 665.0 COG0358@1|root,COG0358@2|Bacteria,3790T@32066|Fusobacteria 32066|Fusobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_N,zf-CHC2 k59_1019855_3 572544.Ilyop_0188 1.63e-192 545.0 COG0568@1|root,COG0568@2|Bacteria,378ZN@32066|Fusobacteria 32066|Fusobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth sigA - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1019855_4 572544.Ilyop_0189 5.88e-100 305.0 COG0568@1|root,COG0568@2|Bacteria,378ZN@32066|Fusobacteria 2|Bacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1019855_5 572544.Ilyop_0190 1.07e-125 372.0 COG0327@1|root,COG0327@2|Bacteria,379A6@32066|Fusobacteria 32066|Fusobacteria S Dinuclear metal center protein, YbgI family - - - - - - - - - - - - NIF3 k59_694362_3 572544.Ilyop_1753 7.48e-209 585.0 COG1104@1|root,COG1104@2|Bacteria,378KB@32066|Fusobacteria 32066|Fusobacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine nifS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_694362_4 1278306.KB906924_gene1526 3.07e-19 80.9 COG0822@1|root,COG0822@2|Bacteria,37A6D@32066|Fusobacteria 32066|Fusobacteria C NifU-like N terminal domain nifU - - ko:K04488 - - - - ko00000 - - - NifU_N k59_171707_1 582899.Hden_0695 7.52e-32 115.0 2AKRU@1|root,31BIQ@2|Bacteria,1Q7DM@1224|Proteobacteria,2UEKS@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_171707_2 224324.aq_402 4.83e-38 133.0 COG0509@1|root,COG0509@2|Bacteria 2|Bacteria E glycine decarboxylation via glycine cleavage system gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_825089_1 251229.Chro_2416 2.23e-42 152.0 COG0583@1|root,COG0583@2|Bacteria,1G1R9@1117|Cyanobacteria,3VI37@52604|Pleurocapsales 1117|Cyanobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_39416_1 1229205.BUPH_02771 7.45e-103 313.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,1K4T4@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the malate synthase family aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_465979_1 267608.RSp0251 8.91e-17 81.6 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,1K2CU@119060|Burkholderiaceae 28216|Betaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_465979_2 323259.Mhun_1341 1.67e-10 58.9 COG1918@1|root,arCOG02102@2157|Archaea,2Y1P2@28890|Euryarchaeota 28890|Euryarchaeota P PFAM FeoA feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_857821_28 1049564.TevJSym_ah00320 4.34e-73 236.0 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1J65J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T MucB/RseB C-terminal domain rseB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045152 - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_857821_29 1049564.TevJSym_ah00330 4.57e-29 111.0 COG3086@1|root,COG3086@2|Bacteria,1PVAZ@1224|Proteobacteria,1TAW9@1236|Gammaproteobacteria,1J7DW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Positive regulator of sigma(E), RseC/MucC - - - - - - - - - - - - RseC_MucC k59_857821_30 2340.JV46_28340 1.96e-179 518.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4K6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the peptidase S1C family mucD GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_857821_31 1218075.BAYA01000009_gene2938 4.87e-06 47.8 COG0695@1|root,COG0695@2|Bacteria,1N82H@1224|Proteobacteria,2VWG7@28216|Betaproteobacteria,1K9F5@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM glutaredoxin 2 - - - - - - - - - - - - DUF836 k59_857821_32 2340.JV46_28360 0.0 984.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1J4DD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_857821_33 768671.ThimaDRAFT_4262 1.02e-132 384.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1WXAU@135613|Chromatiales 135613|Chromatiales U Belongs to the peptidase S26 family - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_857821_34 1283300.ATXB01000001_gene1004 3.88e-22 91.3 COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1XFGK@135618|Methylococcales 135618|Methylococcales NU Domain of unknown function (DUF4845) - - - - - - - - - - - - DUF4845 k59_857821_35 2340.JV46_28390 3.86e-75 233.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1J5PS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_857821_36 765910.MARPU_08875 2.16e-138 399.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1WW0G@135613|Chromatiales 135613|Chromatiales J An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_857821_37 339670.Bamb_1012 1.8e-40 147.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,1K38E@119060|Burkholderiaceae 28216|Betaproteobacteria L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_857821_38 1249627.D779_2231 1.7e-120 350.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1WXFG@135613|Chromatiales 135613|Chromatiales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_857821_39 314278.NB231_07337 1.21e-105 312.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1WWNN@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine - - 2.4.2.28,2.4.2.44 ko:K00772,ko:K19696 ko00270,ko01100,map00270,map01100 M00034 R01402,R09668 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_857821_40 483219.LILAB_19435 1.46e-13 78.6 2DHGV@1|root,2ZZQ6@2|Bacteria,1PP99@1224|Proteobacteria,433YK@68525|delta/epsilon subdivisions,2X438@28221|Deltaproteobacteria,2YY56@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_857821_41 203275.BFO_2162 8.78e-89 285.0 COG4452@1|root,COG4452@2|Bacteria,4NGKY@976|Bacteroidetes,2FN18@200643|Bacteroidia,22X6Q@171551|Porphyromonadaceae 976|Bacteroidetes V Inner membrane protein CreD creD - - ko:K06143 - - - - ko00000 - - - CreD k59_857821_42 1219077.VAZ01S_048_00240 4.14e-83 253.0 COG3208@1|root,COG3208@2|Bacteria,1R0QV@1224|Proteobacteria,1T4NZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Thioesterase involved in non-ribosomal peptide biosynthesis - - - - - - - - - - - - - k59_857821_43 1236541.BALL01000010_gene1686 6.05e-111 331.0 28M95@1|root,2ZAN4@2|Bacteria,1R588@1224|Proteobacteria,1RQZF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zinc dependent phospholipase C - - - - - - - - - - - - Zn_dep_PLPC k59_857821_45 652103.Rpdx1_3644 6.9e-150 435.0 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2U3P9@28211|Alphaproteobacteria,3JRA5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_857821_46 1348635.BBJY01000014_gene789 6.29e-128 382.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria,1XVHW@135623|Vibrionales 135623|Vibrionales E Pyridoxal-dependent decarboxylase, pyridoxal binding domain - - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_857821_47 95619.PM1_0220760 1.19e-134 389.0 COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_0125,iPC815.YPO3411,iSDY_1059.SDY_0028 Spermine_synt_N,Spermine_synth k59_857821_48 1121405.dsmv_1941 1.57e-61 194.0 COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,42XUE@68525|delta/epsilon subdivisions,2WT1M@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_857821_50 1547437.LL06_08330 1.61e-45 159.0 COG3921@1|root,COG3921@2|Bacteria,1PZMM@1224|Proteobacteria,2TR6H@28211|Alphaproteobacteria,43R9C@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Extensin-like protein C-terminus - - - - - - - - - - - - Extensin-like_C k59_857821_51 697282.Mettu_0831 5.83e-104 310.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1XEJI@135618|Methylococcales 135618|Methylococcales L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_857821_52 1049564.TevJSym_bc00220 4.19e-65 199.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1J6FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU PilZ domain pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_857821_53 944435.AXAJ01000006_gene3711 6.16e-49 174.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2VNED@28216|Betaproteobacteria,1K0JG@119060|Burkholderiaceae 28216|Betaproteobacteria L dna polymerase iii holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_857821_54 765912.Thimo_2375 1.24e-69 218.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1WX8U@135613|Chromatiales 135613|Chromatiales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_857821_55 631362.Thi970DRAFT_03609 1.35e-103 315.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1WWK3@135613|Chromatiales 135613|Chromatiales S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_857821_56 697282.Mettu_0826 9.26e-76 239.0 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1XEKT@135618|Methylococcales 135618|Methylococcales EH PFAM Aminotransferase, class IV pabC - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k59_857821_57 1049564.TevJSym_bc00170 1.59e-236 657.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1J5M1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365 Ketoacyl-synt_C,ketoacyl-synt k59_727214_1 247634.GPB2148_2475 1.27e-48 177.0 2CCQP@1|root,30WSJ@2|Bacteria,1RFAQ@1224|Proteobacteria,1S4AU@1236|Gammaproteobacteria,1J7RD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_204753_2 645512.GCWU000246_01691 6.7e-88 294.0 COG0568@1|root,COG0568@2|Bacteria,3TACS@508458|Synergistetes 508458|Synergistetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth sigA - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_989248_1 469617.FUAG_03208 3.24e-37 142.0 COG2244@1|root,COG2244@2|Bacteria,378VM@32066|Fusobacteria 32066|Fusobacteria S polysaccharide biosynthetic process - - - - - - - - - - - - Polysacc_synt k59_74244_1 715451.ambt_04985 1.44e-39 143.0 2AYXV@1|root,31R3M@2|Bacteria,1RBR9@1224|Proteobacteria,1S3B8@1236|Gammaproteobacteria,466GM@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1021765_1 944564.HMPREF9200_0099 2.56e-16 77.0 COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,4H4FR@909932|Negativicutes 909932|Negativicutes K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k59_1021765_2 454957.IA64_08460 3.26e-13 71.2 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1X4MV@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_368429_1 1122929.KB908216_gene2263 1.68e-44 162.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2TQP6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein related to deoxyribodipyrimidine photolyase phrB GO:0000166,GO:0000719,GO:0003674,GO:0003824,GO:0003913,GO:0003914,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_564574_2 572544.Ilyop_1266 6.39e-213 602.0 COG2204@1|root,COG2204@2|Bacteria,378EU@32066|Fusobacteria 32066|Fusobacteria T Bacterial regulatory protein, Fis family - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_564574_3 1319815.HMPREF0202_00024 4.98e-25 102.0 COG2812@1|root,COG2812@2|Bacteria,378A7@32066|Fusobacteria 32066|Fusobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_955807_1 999425.HMPREF9186_00453 6.76e-24 102.0 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,4HA60@91061|Bacilli 91061|Bacilli H Involved in the biosynthesis of porphyrin-containing compound hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_955807_2 572544.Ilyop_0260 2.43e-91 275.0 COG0325@1|root,COG0325@2|Bacteria,379QE@32066|Fusobacteria 32066|Fusobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_955807_3 572544.Ilyop_0261 4.36e-30 115.0 COG1799@1|root,COG1799@2|Bacteria,37AJN@32066|Fusobacteria 32066|Fusobacteria D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA - - - ko:K09772 - - - - ko00000,ko03036 - - - SepF k59_955807_4 398767.Glov_2937 1.56e-17 81.3 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,42V63@68525|delta/epsilon subdivisions 1224|Proteobacteria K transcriptional regulator, Rrf2 family - - - - - - - - - - - - Rrf2 k59_955807_5 264732.Moth_1971 3.15e-131 382.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,42F5Y@68295|Thermoanaerobacterales 186801|Clostridia E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_955807_6 572544.Ilyop_0263 2.24e-166 473.0 COG0301@1|root,COG0301@2|Bacteria,378R9@32066|Fusobacteria 32066|Fusobacteria H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI k59_955807_7 565034.BHWA1_00549 1.09e-20 105.0 COG0840@1|root,COG2703@1|root,COG0840@2|Bacteria,COG2703@2|Bacteria 2|Bacteria P oxygen carrier activity mcp34H-3 - - ko:K03406,ko:K03776,ko:K05874,ko:K07216 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1 k59_955807_8 639282.DEFDS_2132 4.12e-30 121.0 COG2984@1|root,COG2984@2|Bacteria 2|Bacteria S ABC transporter substrate binding protein - - - - - - - - - - - - ABC_sub_bind k59_74250_1 519989.ECTPHS_03036 5.42e-122 373.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_629913_1 519441.Smon_0484 5.9e-05 43.9 2EP66@1|root,33GSW@2|Bacteria,37B8F@32066|Fusobacteria 32066|Fusobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_629913_2 572544.Ilyop_0183 9.51e-95 280.0 COG0194@1|root,COG0194@2|Bacteria,379NK@32066|Fusobacteria 32066|Fusobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_989264_1 335543.Sfum_2709 8.44e-63 208.0 COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria,2MR85@213462|Syntrophobacterales 28221|Deltaproteobacteria H Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_662848_1 1172190.M947_07455 3.85e-88 271.0 COG1373@1|root,COG1373@2|Bacteria,1QP8R@1224|Proteobacteria,42SQ9@68525|delta/epsilon subdivisions,2YPG4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ATPase (AAA - - - ko:K07133 - - - - ko00000 - - - AAA_14 k59_825628_1 1408422.JHYF01000004_gene1565 6.78e-56 191.0 COG0246@1|root,COG0246@2|Bacteria,1TPZU@1239|Firmicutes,248J5@186801|Clostridia,36FPY@31979|Clostridiaceae 186801|Clostridia G Belongs to the mannitol dehydrogenase family. UxaB subfamily uxaB - 1.1.1.58 ko:K00041 ko00040,ko01100,map00040,map01100 M00631 R02555 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_825628_2 469616.FMAG_01347 1.64e-204 580.0 COG2721@1|root,COG2721@2|Bacteria,378ZM@32066|Fusobacteria 32066|Fusobacteria G SAF - - 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_727237_2 1121931.AUHG01000015_gene1284 4.41e-110 337.0 COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes,1HXV0@117743|Flavobacteriia 976|Bacteroidetes E Asparagine synthase, glutamine-hydrolyzing asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_596914_1 387093.SUN_1569 2.91e-51 177.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,42M6T@68525|delta/epsilon subdivisions,2YMJD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_140028_1 102107.XP_008224000.1 3.93e-56 197.0 28JZI@1|root,2QSDY@2759|Eukaryota,37J4T@33090|Viridiplantae,3GC2Z@35493|Streptophyta,4JREA@91835|fabids 35493|Streptophyta U Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope ycf1 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009507,GO:0009526,GO:0009528,GO:0009536,GO:0009706,GO:0009941,GO:0015031,GO:0015833,GO:0016020,GO:0019866,GO:0031090,GO:0031967,GO:0031969,GO:0031975,GO:0033036,GO:0042170,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - - - - - - - - - - Ycf1 k59_107222_1 929558.SMGD1_0405 3.82e-93 286.0 COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,42QHG@68525|delta/epsilon subdivisions,2YN5C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - ko:K07307 ko00920,map00920 - R09501 RC02555 ko00000,ko00001,ko02000 5.A.3.3 - - DmsC,Fer4_11,Fer4_4 k59_1021783_1 1095769.CAHF01000022_gene225 2.47e-140 410.0 COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,2VN94@28216|Betaproteobacteria,476H6@75682|Oxalobacteraceae 28216|Betaproteobacteria G Strictosidine synthase - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2,SGL,Str_synth k59_432747_1 94122.Shewana3_0419 3.13e-65 218.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,2QAYJ@267890|Shewanellaceae 1236|Gammaproteobacteria NU General secretory system II, protein E domain protein pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_596924_1 1121015.N789_05980 9.46e-195 553.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1X39C@135614|Xanthomonadales 135614|Xanthomonadales S Peptidase M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_204811_1 272562.CA_C2564 2.56e-92 278.0 2C4R5@1|root,2Z7JK@2|Bacteria,1TQIE@1239|Firmicutes,24879@186801|Clostridia,36FFQ@31979|Clostridiaceae 186801|Clostridia S GGGtGRT protein - - - - - - - - - - - - GGGtGRT k59_336229_1 929558.SMGD1_2277 2.68e-73 232.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2YMQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_336229_2 563040.Saut_0782 9.15e-52 171.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2YNYJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_727254_1 316056.RPC_4834 3.65e-57 194.0 COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,3JS29@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Saccharopine dehydrogenase C-terminal domain hss - 2.5.1.44 ko:K00808 ko00960,ko01110,map00960,map01110 - R00018 RC00053 ko00000,ko00001,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_107235_1 717231.Flexsi_1320 3.44e-67 229.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GEXA@200930|Deferribacteres 200930|Deferribacteres C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8 k59_74291_1 768670.Calni_1013 7.22e-14 70.5 COG1573@1|root,COG1573@2|Bacteria,2GFD7@200930|Deferribacteres 200930|Deferribacteres L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_74291_2 666681.M301_1956 2.59e-21 91.7 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,2KKVH@206350|Nitrosomonadales 206350|Nitrosomonadales K RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_400388_1 349102.Rsph17025_1814 3.98e-134 385.0 COG2801@1|root,COG2801@2|Bacteria,1MVQ9@1224|Proteobacteria,2TTHG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - rve,rve_3 k59_791540_1 1249627.D779_3022 1.99e-63 199.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1WX78@135613|Chromatiales 135613|Chromatiales C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_140053_1 1168034.FH5T_04235 3.64e-32 112.0 COG0828@1|root,COG0828@2|Bacteria,4NUPV@976|Bacteroidetes,2FUNX@200643|Bacteroidia 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bS21 family rpsU - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_140053_2 929556.Solca_0409 6.58e-18 83.2 COG4974@1|root,COG4974@2|Bacteria,4NGQW@976|Bacteroidetes,1IP2Y@117747|Sphingobacteriia 976|Bacteroidetes L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_204813_1 203119.Cthe_0295 4.14e-208 582.0 COG1932@1|root,COG1932@2|Bacteria,1UHH6@1239|Firmicutes,25Q8I@186801|Clostridia,3WI3X@541000|Ruminococcaceae 186801|Clostridia EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine - - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_204813_2 574087.Acear_1687 8.4e-17 82.0 COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,3WARU@53433|Halanaerobiales 186801|Clostridia J Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 k59_532198_2 32042.PstZobell_05348 4.46e-08 56.6 2ADX9@1|root,313PE@2|Bacteria,1RGY0@1224|Proteobacteria,1S83N@1236|Gammaproteobacteria,1Z343@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Protein of unknown function (DUF2846) - - - - - - - - - - - - DUF2846 k59_466530_1 1168034.FH5T_04270 6.5e-179 504.0 COG0046@1|root,COG0046@2|Bacteria,4NETY@976|Bacteroidetes,2FXM7@200643|Bacteroidia 976|Bacteroidetes F AIR synthase related protein, C-terminal domain purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 k59_564609_1 1511.CLOST_2293 6.16e-157 452.0 COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,25QHW@186804|Peptostreptococcaceae 186801|Clostridia E Belongs to the Glu Leu Phe Val dehydrogenases family gdh GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0071704,GO:1901564 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_564609_2 1121334.KB911067_gene87 4.28e-151 429.0 COG0491@1|root,COG0491@2|Bacteria,1UU56@1239|Firmicutes,24BKN@186801|Clostridia 186801|Clostridia M PFAM Metallo-beta-lactamase superfamily - - 3.1.1.81 ko:K13075 ko02024,map02024 - R08970 RC00713 ko00000,ko00001,ko01000 - - - Lactamase_B k59_826733_2 247639.MGP2080_09131 1.43e-09 56.2 COG3909@1|root,COG3909@2|Bacteria,1N1E5@1224|Proteobacteria,1S4BY@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome - - - - - - - - - - - - Cytochrom_C_2 k59_500643_1 13035.Dacsa_2625 1.34e-25 110.0 COG3210@1|root,COG3595@1|root,COG4070@1|root,COG3210@2|Bacteria,COG3595@2|Bacteria,COG4070@2|Bacteria 2|Bacteria U domain, Protein - - - ko:K15125,ko:K20276 ko02024,ko05133,map02024,map05133 - - - ko00000,ko00001,ko00536 - - - CHU_C,DUF4097,FG-GAP_2,Glug,Haemagg_act,Laminin_G_3,PA14,SprB k59_792269_1 1380600.AUYN01000009_gene1189 6.21e-49 173.0 COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes,1HWXD@117743|Flavobacteriia 976|Bacteroidetes E aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_792269_2 1178825.ALIH01000002_gene1086 7e-06 47.0 COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,1HWN8@117743|Flavobacteriia 976|Bacteroidetes C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_695887_1 1122603.ATVI01000005_gene3477 4.97e-118 357.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1X45G@135614|Xanthomonadales 135614|Xanthomonadales E Acetolactate synthase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_270217_2 880072.Desac_1322 4.92e-53 182.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,42MHN@68525|delta/epsilon subdivisions,2WJU0@28221|Deltaproteobacteria,2MQNQ@213462|Syntrophobacterales 28221|Deltaproteobacteria P PFAM Citrate transporter - - - - - - - - - - - - CitMHS k59_858934_1 1121939.L861_17570 3.81e-100 305.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1XR9F@135619|Oceanospirillales 135619|Oceanospirillales L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_270218_1 243233.MCA1967 1.28e-42 146.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1XEZ9@135618|Methylococcales 135618|Methylococcales Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_108297_1 1123393.KB891317_gene2190 6.45e-49 173.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJJV@28216|Betaproteobacteria,1KSRR@119069|Hydrogenophilales 119069|Hydrogenophilales EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_500655_1 1255043.TVNIR_3015 1.15e-30 115.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1WYZ4@135613|Chromatiales 135613|Chromatiales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_500655_2 1248916.ANFY01000010_gene401 3.38e-08 55.5 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2U0Q3@28211|Alphaproteobacteria,2K4RS@204457|Sphingomonadales 204457|Sphingomonadales S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_6255_1 1036674.A28LD_0978 6.42e-28 115.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1S3EU@1236|Gammaproteobacteria,2QGY6@267893|Idiomarinaceae 1236|Gammaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_369624_1 935261.JAGL01000001_gene1718 5.45e-21 93.6 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,43H4U@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L ATP-dependent helicase hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_728180_1 572544.Ilyop_0287 7.25e-315 872.0 COG1048@1|root,COG1048@2|Bacteria,378WX@32066|Fusobacteria 32066|Fusobacteria C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_925556_1 1168034.FH5T_04985 8.69e-19 80.9 COG0102@1|root,COG0102@2|Bacteria,4NNGA@976|Bacteroidetes,2FS3I@200643|Bacteroidia 976|Bacteroidetes J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_925556_2 1168034.FH5T_04980 1.4e-60 189.0 COG0103@1|root,COG0103@2|Bacteria,4NNN1@976|Bacteroidetes,2FSGZ@200643|Bacteroidia 976|Bacteroidetes J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_401564_1 396588.Tgr7_0998 2.48e-22 96.3 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales 135613|Chromatiales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1022556_3 760192.Halhy_5577 3.32e-16 74.3 2ET4W@1|root,33KNZ@2|Bacteria,4P5X3@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1022556_4 1278309.KB907099_gene3134 5.65e-95 288.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria 1236|Gammaproteobacteria G protein conserved in bacteria - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF455 k59_1022556_5 378806.STAUR_5456 2.24e-32 122.0 COG1719@1|root,COG1719@2|Bacteria,1Q2HA@1224|Proteobacteria,4383Z@68525|delta/epsilon subdivisions,2X3DY@28221|Deltaproteobacteria,2YVMM@29|Myxococcales 28221|Deltaproteobacteria S 4-vinyl reductase, 4VR - - - - - - - - - - - - - k59_1022556_6 315730.BcerKBAB4_4761 8.21e-63 193.0 COG2824@1|root,COG2824@2|Bacteria,1V6NA@1239|Firmicutes,4HIKN@91061|Bacilli,1ZH56@1386|Bacillus 91061|Bacilli P Alkylphosphonate utilization operon protein PhnA phnA - - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k59_1022556_7 713586.KB900536_gene1205 6.84e-92 276.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales 135613|Chromatiales E HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - - - - - - - - - - HAD k59_1022556_8 768671.ThimaDRAFT_1006 3.21e-60 191.0 COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,1T1KA@1236|Gammaproteobacteria,1X2U2@135613|Chromatiales 135613|Chromatiales F Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_1022556_9 1049564.TevJSym_bp00060 0.0 984.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1J4VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08483,ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1022556_10 1049564.TevJSym_al00300 5.17e-148 427.0 COG0842@1|root,COG0842@2|Bacteria,1QTBE@1224|Proteobacteria,1RNG9@1236|Gammaproteobacteria,1J4E1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 k59_1022556_11 1123399.AQVE01000001_gene692 5.82e-123 360.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,461ME@72273|Thiotrichales 72273|Thiotrichales V AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - ABC_tran k59_1022556_12 1121448.DGI_3104 5.09e-164 490.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_1022556_13 1123288.SOV_4c02050 5.26e-44 152.0 COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,4H3F2@909932|Negativicutes 1239|Firmicutes S LemA family lemA2 - - ko:K03744 - - - - ko00000 - - - LemA k59_1022556_14 1278309.KB907108_gene1575 1.99e-151 434.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria,1XHGV@135619|Oceanospirillales 135619|Oceanospirillales S C4-dicarboxylate ABC transporter substrate-binding protein - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1022556_15 1049564.TevJSym_an00220 6.06e-127 371.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1J4J2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_1022556_16 702113.PP1Y_AT7063 1.91e-87 269.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2K0Q8@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - Metallophos,Metallophos_2 k59_1022556_17 472759.Nhal_0665 3.81e-126 373.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,1RQYE@1236|Gammaproteobacteria,1WW8E@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1022556_18 62928.azo0147 5.51e-246 721.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2VKJT@28216|Betaproteobacteria,2KVH0@206389|Rhodocyclales 206389|Rhodocyclales C Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k59_1022556_19 1215092.PA6_002_00340 1.72e-36 147.0 2B3X8@1|root,31WM6@2|Bacteria,1RFUV@1224|Proteobacteria,1RNAH@1236|Gammaproteobacteria,1YDAE@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Protein of unknown function (DUF3999) - - - - - - - - - - - - DUF3999 k59_1022556_20 1249627.D779_1664 8.95e-148 425.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1WWXT@135613|Chromatiales 135613|Chromatiales V PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1022556_21 765911.Thivi_2623 4.85e-119 347.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1WW0K@135613|Chromatiales 135613|Chromatiales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1022556_22 745411.B3C1_03175 7.52e-29 112.0 2EC1K@1|root,3360Q@2|Bacteria,1NCHK@1224|Proteobacteria,1SFZB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1022556_23 1216007.AOPM01000002_gene2610 7.82e-173 518.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNFK@1236|Gammaproteobacteria,2Q0GF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07641 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_1022556_24 1121921.KB898706_gene3121 1.81e-102 303.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RM87@1236|Gammaproteobacteria,2PMM9@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T Transcriptional regulatory protein, C terminal chvI GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K02483,ko:K07663 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1022556_25 2340.JV46_09700 1.04e-60 194.0 COG3448@1|root,COG3448@2|Bacteria,1QUQ5@1224|Proteobacteria,1T20R@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1022556_26 1049564.TevJSym_ag00950 4.29e-137 397.0 COG1092@1|root,COG1092@2|Bacteria,1QW1V@1224|Proteobacteria,1T4CI@1236|Gammaproteobacteria,1JC2Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J S-adenosylmethionine-dependent methyltransferase rlmL - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_1022556_27 1049564.TevJSym_ca00030 1.15e-123 384.0 COG0419@1|root,COG1121@1|root,COG0419@2|Bacteria,COG1121@2|Bacteria 2|Bacteria P zinc-transporting ATPase activity - - - ko:K03546,ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko03400 3.A.1.15.3,3.A.1.15.5 - - AAA_23,ABC_tran,SbcCD_C k59_1022556_30 1282876.BAOK01000001_gene1269 1.09e-201 595.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,2TV9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_1022556_31 523791.Kkor_2416 3.05e-53 176.0 COG3764@1|root,COG3764@2|Bacteria,1P806@1224|Proteobacteria,1S9RI@1236|Gammaproteobacteria,1XMGQ@135619|Oceanospirillales 135619|Oceanospirillales M Sortase (surface protein transpeptidase) - - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase k59_1022556_32 1123252.ATZF01000007_gene328 5.81e-57 187.0 COG3757@1|root,COG3757@2|Bacteria,1V484@1239|Firmicutes,4HJNJ@91061|Bacilli,27BR8@186824|Thermoactinomycetaceae 91061|Bacilli M Glycosyl hydrolases family 25 - - - ko:K07273 - - - - ko00000 - - - Glyco_hydro_25,PG_binding_1 k59_1022556_33 1333507.AUTQ01000252_gene2911 9.95e-101 297.0 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1RPXT@1236|Gammaproteobacteria,2Q3D8@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S ErfK YbiS YcfS YnhG family protein yafK - - - - - - - - - - - YkuD k59_1022556_34 1056512.D515_04906 2.42e-50 174.0 2EMFB@1|root,33F44@2|Bacteria,1NH7D@1224|Proteobacteria,1SGY2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2059) - - - - - - - - - - - - DUF2059 k59_1022556_36 1385935.N836_22985 1.49e-37 146.0 COG0004@1|root,COG2199@1|root,COG0004@2|Bacteria,COG2199@2|Bacteria 2|Bacteria T diguanylate cyclase activity - - 2.7.7.65 ko:K03320,ko:K21021 ko02025,map02025 - - - ko00000,ko00001,ko01000,ko02000 1.A.11 - - Ammonium_transp,CHASE3,EAL,GGDEF,PAS_9 k59_1022556_37 859657.RPSI07_mp1194 7.5e-96 306.0 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1N17V@1224|Proteobacteria,2VK7C@28216|Betaproteobacteria,1K33Z@119060|Burkholderiaceae 28216|Betaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_1022556_38 338966.Ppro_2228 4.45e-91 274.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42QPB@68525|delta/epsilon subdivisions,2WMP0@28221|Deltaproteobacteria,43T71@69541|Desulfuromonadales 28221|Deltaproteobacteria K response regulator - - - ko:K07664 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1022556_39 631362.Thi970DRAFT_04629 1.43e-190 546.0 COG1262@1|root,COG1262@2|Bacteria,1R6GS@1224|Proteobacteria,1S5ET@1236|Gammaproteobacteria,1WYQP@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1566) - - - - - - - - - - - - DUF1566 k59_1022556_42 756272.Plabr_3756 5.12e-279 776.0 COG4146@1|root,COG4146@2|Bacteria,2J1R6@203682|Planctomycetes 203682|Planctomycetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1022556_43 1158292.JPOE01000002_gene3753 7.95e-25 115.0 COG2199@1|root,COG2200@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,2W216@28216|Betaproteobacteria,1KJFZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS_9,Protoglobin k59_1022556_44 324925.Ppha_2418 2.7e-140 408.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - - - - - - - - - - DUF4892,OmpA k59_1022556_45 1125973.JNLC01000013_gene3950 2.28e-152 443.0 COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria,3JRXG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Transglycosylase SLT domain MA20_44755 - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - PG_binding_1,SLT_2 k59_1022556_46 640511.BC1002_5081 1.13e-57 183.0 COG1607@1|root,COG1607@2|Bacteria,1REI5@1224|Proteobacteria,2W8UX@28216|Betaproteobacteria,1K4PY@119060|Burkholderiaceae 28216|Betaproteobacteria I PFAM thioesterase superfamily protein - - - - - - - - - - - - 4HBT k59_1022556_47 697282.Mettu_3598 2.12e-133 388.0 COG3272@1|root,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1XEGF@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_1022556_48 1485545.JQLW01000006_gene315 4.86e-29 123.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0016740,GO:0016772,GO:0016779,GO:0019825,GO:0020037,GO:0036094,GO:0042165,GO:0043167,GO:0043169,GO:0046906,GO:0048037,GO:0052621,GO:0070025,GO:0097159,GO:1901363 2.7.7.65 ko:K13069,ko:K18967 - - R08057 - ko00000,ko01000,ko02000 9.B.34.1.1 - - GGDEF,PAS k59_1022556_49 1049564.TevJSym_an00640 1.56e-161 462.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1J4SK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1022556_50 1049564.TevJSym_an00630 4.46e-203 569.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1J4WN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_1022556_51 1158760.AQXP01000041_gene1914 8.41e-25 100.0 COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,1SAAR@1236|Gammaproteobacteria,1X1DX@135613|Chromatiales 135613|Chromatiales M 17 kDa outer membrane surface antigen - - - - - - - - - - - - 17kDa_Anti_2,Gly-zipper_Omp,Rick_17kDa_Anti k59_1022556_52 1049564.TevJSym_ab00900 1.13e-85 253.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam Rhodanese-like - - - - - - - - - - - - Rhodanese k59_1022556_53 765912.Thimo_0111 2.34e-73 235.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,1WVUP@135613|Chromatiales 135613|Chromatiales M Lipid A biosynthesis acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_1022556_54 1049564.TevJSym_ab00910 1.46e-155 470.0 COG2304@1|root,COG2304@2|Bacteria,1MVJ2@1224|Proteobacteria,1RMUF@1236|Gammaproteobacteria,1J5FC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S von Willebrand factor type A domain - - - - - - - - - - - - VWA,VWA_3 k59_1022556_56 1123401.JHYQ01000026_gene3243 1.02e-14 71.2 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria,4619K@72273|Thiotrichales 72273|Thiotrichales S PFAM Sulphur oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_1022556_57 1042375.AFPL01000032_gene899 3.48e-13 70.5 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1RU3J@1236|Gammaproteobacteria,46BFD@72275|Alteromonadaceae 1236|Gammaproteobacteria S Sulfur oxidation protein SoxY - - - - - - - - - - - - SoxY k59_1022556_58 1218075.BAYA01000012_gene3564 4.52e-57 207.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1K0VI@119060|Burkholderiaceae 28216|Betaproteobacteria S Peptidase M48 yggG_1 - - - - - - - - - - - Peptidase_M48,TPR_19 k59_1022556_59 1163617.SCD_n00462 8.42e-128 373.0 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria 28216|Betaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_1022556_61 2340.JV46_13220 2.14e-64 203.0 28IET@1|root,2Z8GT@2|Bacteria,1R4FQ@1224|Proteobacteria,1RS8I@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1022556_62 1049564.TevJSym_aw00260 7.47e-55 173.0 COG2920@1|root,COG2920@2|Bacteria,1RISY@1224|Proteobacteria,1S8HB@1236|Gammaproteobacteria 1236|Gammaproteobacteria P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1022556_63 631362.Thi970DRAFT_01392 6.3e-47 162.0 2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - - - - - - - - - - Cas6 k59_1022556_64 1049564.TevJSym_aw00240 5.39e-94 282.0 COG0457@1|root,COG0457@2|Bacteria,1R85G@1224|Proteobacteria,1S0MD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1022556_65 2340.JV46_21570 5.37e-17 73.9 2E3CD@1|root,32YBP@2|Bacteria,1N8PD@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1022556_66 1049564.TevJSym_aw00210 1.02e-259 716.0 COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,1RSIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TIGRFAM sulfite reductase, dissimilatory-type alpha subunit dsrA - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_1022556_67 1049564.TevJSym_aw00190 3.35e-232 641.0 COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria 1224|Proteobacteria C TIGRFAM sulfite reductase, dissimilatory-type beta subunit dsrB - 1.8.99.5 ko:K11181 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr k59_1022556_68 1049564.TevJSym_aw00180 8.65e-82 243.0 COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1J6HU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P conserved protein involved in intracellular sulfur reduction tusD GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019417,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - ko:K07235 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE k59_1022556_70 1049564.TevJSym_aw00160 1.8e-40 136.0 COG2168@1|root,COG2168@2|Bacteria 2|Bacteria P tRNA wobble position uridine thiolation tusB GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - ko:K07237 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DsrH k59_1022556_71 2340.JV46_15470 5.65e-64 196.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1J6P0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P part of a sulfur-relay system tusE GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1023269_1 338966.Ppro_0061 1.34e-46 168.0 COG1132@1|root,COG1132@2|Bacteria,1MXC2@1224|Proteobacteria,42PQK@68525|delta/epsilon subdivisions,2WJCT@28221|Deltaproteobacteria,43T12@69541|Desulfuromonadales 28221|Deltaproteobacteria V ABC transporter - - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_859701_1 1165841.SULAR_08714 9.42e-111 335.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H ATP citrate synthase - - 2.3.3.8 ko:K15230 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,Ligase_CoA k59_957943_1 572544.Ilyop_1242 2.97e-112 337.0 COG4591@1|root,COG4591@2|Bacteria 2|Bacteria M lipoprotein localization to outer membrane - - - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD k59_957943_2 572544.Ilyop_1241 7.17e-31 119.0 COG4591@1|root,COG4591@2|Bacteria 2|Bacteria M lipoprotein localization to outer membrane - - - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD k59_631809_1 1448139.AI20_12335 3.99e-18 83.2 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,1RP2I@1236|Gammaproteobacteria,1Y51V@135624|Aeromonadales 135624|Aeromonadales P SBF-like CPA transporter family (DUF4137) - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_468856_1 240016.ABIZ01000001_gene1012 5.01e-81 263.0 COG0542@1|root,COG0542@2|Bacteria,46SD6@74201|Verrucomicrobia,2ITPB@203494|Verrucomicrobiae 203494|Verrucomicrobiae O C-terminal, D2-small domain, of ClpB protein - - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_207703_1 1120965.AUBV01000012_gene1394 6.91e-28 106.0 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_Tnp_1 k59_860476_1 414684.RC1_0800 3.94e-53 180.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,2TU50@28211|Alphaproteobacteria,2JSBB@204441|Rhodospirillales 204441|Rhodospirillales U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_860476_2 1122137.AQXF01000001_gene2819 4.04e-06 48.5 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,2UAB1@28211|Alphaproteobacteria 28211|Alphaproteobacteria U TonB system transport protein ExbB - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_239901_1 1157943.KB892705_gene480 4.32e-42 149.0 COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,235XR@1762|Mycobacteriaceae 201174|Actinobacteria GM epimerase dehydratase - - 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_239901_2 196490.AUEZ01000050_gene372 4.73e-44 154.0 COG0500@1|root,COG0500@2|Bacteria,1MVD1@1224|Proteobacteria,2TUKG@28211|Alphaproteobacteria,3JW9U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_1023981_1 1382356.JQMP01000001_gene733 1.26e-17 87.8 COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,2G6KJ@200795|Chloroflexi,27YNQ@189775|Thermomicrobia 189775|Thermomicrobia S Uncharacterised conserved protein (DUF2156) - - 2.3.2.3 ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504 2.A.1.3.37 - - DUF2156,LPG_synthase_TM k59_927050_1 1069080.KB913028_gene1191 3.62e-06 52.4 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4H1XX@909932|Negativicutes 909932|Negativicutes M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_927050_2 570967.JMLV01000005_gene8 3.72e-15 84.7 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria,2JSSA@204441|Rhodospirillales 204441|Rhodospirillales HJ Cyanophycin synthetase - - - - - - - - - - - - Mur_ligase_C,Mur_ligase_M,RimK k59_207713_1 1172190.M947_03520 1.97e-31 125.0 COG2911@1|root,COG2911@2|Bacteria,1NRGB@1224|Proteobacteria,42MD0@68525|delta/epsilon subdivisions,2YMIM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_567292_1 1415780.JPOG01000001_gene2824 2.91e-11 69.7 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1X3R2@135614|Xanthomonadales 135614|Xanthomonadales M membrane - - - - - - - - - - - - OapA,Peptidase_M23 k59_42354_1 565045.NOR51B_1871 1.7e-56 193.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RPVQ@1236|Gammaproteobacteria,1J5HP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I alpha/beta hydrolase fold phbC_2 - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_76839_1 1410617.JHXH01000001_gene730 3.25e-24 102.0 COG2607@1|root,COG2607@2|Bacteria,1TQDJ@1239|Firmicutes,2483S@186801|Clostridia,3WH9K@541000|Ruminococcaceae 186801|Clostridia S ATPase (AAA superfamily) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_76839_2 1045854.WKK_03540 1.84e-06 49.3 COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,4HFP8@91061|Bacilli,4AXRA@81850|Leuconostocaceae 91061|Bacilli J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_403054_1 350688.Clos_0924 2.55e-36 138.0 COG5505@1|root,COG5505@2|Bacteria,1TSC8@1239|Firmicutes,24AUN@186801|Clostridia,36FR6@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF819) - - - - - - - - - - - - DUF819 k59_599947_1 717231.Flexsi_0176 4.08e-32 122.0 COG0664@1|root,COG0664@2|Bacteria,2GFJX@200930|Deferribacteres 200930|Deferribacteres K Transcriptional regulator, Crp Fnr family - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_567298_1 1123020.AUIE01000006_gene4198 2.43e-78 258.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1YE6K@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyltransferase,Aminotran_1_2,NAD_binding_4,PP-binding,Thioesterase k59_762328_1 869213.JCM21142_52164 2.08e-35 134.0 COG4908@1|root,COG4908@2|Bacteria,4P25W@976|Bacteroidetes 2|Bacteria S Psort location Cytoplasmic, score - - - - - - - - - - - - AATase k59_762328_2 880072.Desac_0678 4.56e-88 275.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,2MQXS@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_697485_1 1121396.KB893052_gene3396 5.04e-121 355.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,2MIIJ@213118|Desulfobacterales 28221|Deltaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM k59_535110_1 2340.JV46_08130 2.32e-83 266.0 COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1J5DJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C CoA binding domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_697490_1 1168034.FH5T_07970 6.94e-99 294.0 28NPZ@1|root,2ZBPQ@2|Bacteria,4NN3K@976|Bacteroidetes,2FPEH@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - OMP_b-brl_2 k59_175245_1 1165841.SULAR_09614 1.16e-126 373.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2YNCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_958697_1 1408473.JHXO01000006_gene1029 1.09e-33 122.0 COG2427@1|root,COG2427@2|Bacteria,4P4Q4@976|Bacteroidetes,2FYBJ@200643|Bacteroidia 976|Bacteroidetes S Protein of unknown function (DUF1641) - - - - - - - - - - - - - k59_958697_2 1408473.JHXO01000006_gene1028 8.58e-67 213.0 COG0446@1|root,COG0446@2|Bacteria,4NEK6@976|Bacteroidetes,2FT9Y@200643|Bacteroidia 976|Bacteroidetes S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_860520_1 511062.GU3_02145 9.45e-06 47.4 COG2165@1|root,COG2165@2|Bacteria,1NH1V@1224|Proteobacteria,1S36B@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_860520_2 472759.Nhal_0443 1.43e-18 84.0 COG4967@1|root,COG4967@2|Bacteria,1N992@1224|Proteobacteria,1T2RT@1236|Gammaproteobacteria,1WZB5@135613|Chromatiales 135613|Chromatiales U Prokaryotic N-terminal methylation motif - - - ko:K02458 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_599976_2 326298.Suden_0089 2.73e-35 121.0 COG4628@1|root,COG4628@2|Bacteria,1N7DG@1224|Proteobacteria,42VQC@68525|delta/epsilon subdivisions,2YQ7P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DNA-binding protein VF530 - - - - - - - - - - - - VF530 k59_599976_3 709032.Sulku_2033 1.91e-200 559.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2YMY3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O hydrogenase expression formation protein hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_860522_1 177439.DP2923 1.54e-43 152.0 COG1207@1|root,COG1207@2|Bacteria,1RD3B@1224|Proteobacteria,42ZXX@68525|delta/epsilon subdivisions,2WV9N@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Bacterial transferase hexapeptide (six repeats) - - - - - - - - - - - - Hexapep k59_304332_1 485913.Krac_3196 2.32e-12 66.2 COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi 200795|Chloroflexi P Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_304332_2 522306.CAP2UW1_1978 4.31e-17 84.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2W3RM@28216|Betaproteobacteria 28216|Betaproteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_665687_1 1173028.ANKO01000126_gene4119 5.7e-24 107.0 COG0515@1|root,COG0642@1|root,COG2208@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,Pkinase,SpoIIE k59_1024031_1 1165841.SULAR_04848 1.59e-104 312.0 COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,42MVP@68525|delta/epsilon subdivisions,2YMY4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_DAP_Arg_deC k59_992239_1 1123274.KB899407_gene258 1.41e-31 115.0 29IC7@1|root,3059E@2|Bacteria,2JAQH@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - k59_992239_2 572544.Ilyop_1155 3.95e-193 550.0 28I94@1|root,2Z8BU@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_762373_1 1408473.JHXO01000006_gene1304 1.1e-68 209.0 COG0099@1|root,COG0099@2|Bacteria,4NNGZ@976|Bacteroidetes,2FRYC@200643|Bacteroidia 976|Bacteroidetes J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_762373_2 1168034.FH5T_12930 2.49e-85 251.0 COG0100@1|root,COG0100@2|Bacteria,4NNHA@976|Bacteroidetes,2FRZD@200643|Bacteroidia 976|Bacteroidetes J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_762373_3 1168034.FH5T_12935 7.44e-47 154.0 COG0522@1|root,COG0522@2|Bacteria,4NEMZ@976|Bacteroidetes,2FMRC@200643|Bacteroidia 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_599986_1 1379270.AUXF01000001_gene2189 1.32e-131 391.0 COG0365@1|root,COG0365@2|Bacteria,1ZU93@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Acetyl-coenzyme A synthetase N-terminus prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_567343_1 387093.SUN_1147 2.03e-99 305.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2YN7F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_992242_2 1537915.JU57_03740 1.62e-86 268.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2YMNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_665696_1 105559.Nwat_1244 1.14e-51 179.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales 135613|Chromatiales O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_599992_1 1158146.KB907123_gene748 3.78e-39 150.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_793272_2 1196322.A370_04216 3.48e-38 132.0 COG0347@1|root,COG0347@2|Bacteria,1VB4G@1239|Firmicutes,24MQ1@186801|Clostridia,36IVK@31979|Clostridiaceae 186801|Clostridia K Belongs to the P(II) protein family - - - ko:K02590 - - - - ko00000 - - - P-II k59_371113_1 29730.Gorai.013G138600.1 2.47e-17 77.4 COG4799@1|root,KOG0540@2759|Eukaryota 2759|Eukaryota I CoA carboxylase activity accD - 2.1.3.15,4.1.1.39,6.4.1.2,6.4.1.4 ko:K01601,ko:K01963,ko:K01969 ko00061,ko00280,ko00620,ko00630,ko00640,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00165,M00166,M00376,M00532 R00024,R00742,R03140,R04138,R04386 RC00040,RC00172,RC00253,RC00367,RC00859,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans,RuBisCO_large,RuBisCO_large_N k59_143068_2 1168034.FH5T_10680 2.19e-16 78.6 COG2509@1|root,COG2509@2|Bacteria,4NEUQ@976|Bacteroidetes,2FM1G@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score - - - ko:K07137 - - - - ko00000 - - - FAD_binding_2,FAD_binding_3,GIDA,HI0933_like,Pyr_redox_2 k59_893620_1 547045.NEISICOT_01400 1.62e-55 189.0 COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,2VN8K@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage capsid family - - - - - - - - - - - - Peptidase_S78,Phage_capsid k59_729390_1 1232410.KI421424_gene1860 3.75e-112 323.0 COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,43RZJ@69541|Desulfuromonadales 28221|Deltaproteobacteria S ADP-ribosylation factor family mglA - - ko:K06883 - - - - ko00000 - - - Arf,Ras k59_143074_1 1123504.JQKD01000002_gene3997 8.91e-34 132.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VJ0J@28216|Betaproteobacteria,4AD4F@80864|Comamonadaceae 28216|Betaproteobacteria E Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_7108_1 613026.HRAG_01431 3.41e-57 192.0 28NAC@1|root,2ZBE6@2|Bacteria,1R69B@1224|Proteobacteria,431XC@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - Phenol_MetA_deg k59_502465_1 709032.Sulku_1316 2.08e-41 146.0 COG0426@1|root,COG0426@2|Bacteria,1NDXY@1224|Proteobacteria,42N11@68525|delta/epsilon subdivisions,2YNA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Metallo-beta-lactamase superfamily - - 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B k59_502465_2 990073.ATHU01000001_gene1759 2.94e-28 105.0 COG0633@1|root,COG0633@2|Bacteria,1NJF0@1224|Proteobacteria 1224|Proteobacteria C Ferredoxin - - - - - - - - - - - - Fer2 k59_42410_1 519989.ECTPHS_13218 1.96e-157 482.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_304364_1 215803.DB30_2742 5.21e-34 122.0 COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,2YVX9@29|Myxococcales 28221|Deltaproteobacteria E Glyoxalase-like domain mceE - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_927128_1 1121033.AUCF01000001_gene2357 1.18e-53 190.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,2TW4K@28211|Alphaproteobacteria,2JPWC@204441|Rhodospirillales 204441|Rhodospirillales G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_893635_1 1408287.AXUR01000092_gene2094 4.96e-53 190.0 COG1450@1|root,COG1450@2|Bacteria,378RZ@32066|Fusobacteria 32066|Fusobacteria NU Belongs to the GSP D family - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - CarbopepD_reg_2,Secretin,Secretin_N k59_339858_2 323097.Nham_3328 1.42e-05 48.5 COG5301@1|root,COG5301@2|Bacteria,1N6XX@1224|Proteobacteria,2USJX@28211|Alphaproteobacteria 28211|Alphaproteobacteria G cellulose 1,4-beta-cellobiosidase activity - - - - - - - - - - - - - k59_894274_2 1049564.TevJSym_aa01890 2.7e-90 283.0 COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_535651_1 1049564.TevJSym_au00330 4.91e-88 278.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1J5J7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle hbpA - - - - - - - - - - - SBP_bac_5 k59_729931_1 1049564.TevJSym_bv00110 8.4e-82 261.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1J5PE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_503178_1 469618.FVAG_00406 3.11e-154 456.0 COG1132@1|root,COG1132@2|Bacteria,379H4@32066|Fusobacteria 32066|Fusobacteria V K11085 ATP-binding cassette, subfamily B, bacterial MsbA - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_42903_1 316067.Geob_0751 3.9e-49 160.0 COG1832@1|root,COG1832@2|Bacteria,1NJW8@1224|Proteobacteria,42WY1@68525|delta/epsilon subdivisions,2X9YF@28221|Deltaproteobacteria,43V09@69541|Desulfuromonadales 28221|Deltaproteobacteria S CoA binding domain - - - - - - - - - - - - CoA_binding_2 k59_42903_2 1298608.JCM18900_11080 2.37e-21 91.3 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,3NIRE@468|Moraxellaceae 1236|Gammaproteobacteria J glycyl-tRNA synthetase, alpha subunit glyQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 tRNA-synt_2e k59_698142_1 395494.Galf_1768 1.18e-74 244.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,44VEM@713636|Nitrosomonadales 28216|Betaproteobacteria O TIGRFAM cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_698142_2 977880.RALTA_B0644 7.17e-11 60.5 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1K8MK@119060|Burkholderiaceae 28216|Betaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_666341_1 1319815.HMPREF0202_00269 1.48e-39 133.0 COG0776@1|root,COG0776@2|Bacteria,37AGV@32066|Fusobacteria 32066|Fusobacteria L Belongs to the bacterial histone-like protein family - - - ko:K03530,ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_666341_2 293826.Amet_1228 8.25e-115 335.0 COG0560@1|root,COG0560@2|Bacteria,1UYZ6@1239|Firmicutes,24AC7@186801|Clostridia,36EAG@31979|Clostridiaceae 186801|Clostridia E HAD-superfamily subfamily IB hydrolase serB - - - - - - - - - - - HAD k59_208484_2 1265505.ATUG01000001_gene4210 1.47e-09 56.6 COG0662@1|root,COG0662@2|Bacteria,1N1T5@1224|Proteobacteria,42V1T@68525|delta/epsilon subdivisions,2WRU3@28221|Deltaproteobacteria,2MP7U@213118|Desulfobacterales 28221|Deltaproteobacteria G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_1024635_1 1528106.JRJE01000032_gene2644 1.19e-49 174.0 COG2334@1|root,COG2334@2|Bacteria,1QV5C@1224|Proteobacteria,2U09Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH,PhoU k59_567949_1 933262.AXAM01000033_gene1644 8.69e-138 404.0 COG2069@1|root,COG2069@2|Bacteria,1QS8G@1224|Proteobacteria,437H2@68525|delta/epsilon subdivisions,2WKVX@28221|Deltaproteobacteria,2MI1T@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM CO dehydrogenase acetyl-CoA synthase delta subunit - - 2.1.1.245 ko:K00194 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD k59_698147_1 1121403.AUCV01000014_gene4653 6.61e-05 42.7 COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,42V26@68525|delta/epsilon subdivisions 1224|Proteobacteria IQ acyl carrier protein acpP-1 - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_729944_1 1304885.AUEY01000014_gene3371 1.06e-14 74.3 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,42R1A@68525|delta/epsilon subdivisions,2WMV6@28221|Deltaproteobacteria,2MJG5@213118|Desulfobacterales 28221|Deltaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_240415_1 1323663.AROI01000033_gene4058 7.81e-108 328.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E glutamine synthetase puuA GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575 6.3.1.11,6.3.1.2 ko:K01915,ko:K09470 ko00220,ko00250,ko00330,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 M00136 R00253,R07414 RC00010,RC00090,RC00096,RC02798 ko00000,ko00001,ko00002,ko01000,ko04147 - - iB21_1397.B21_01285,iECBD_1354.ECBD_2320,iECB_1328.ECB_01274,iECD_1391.ECD_01274,iSF_1195.SF1302 Gln-synt_C k59_567952_3 259536.Psyc_0980 3.07e-05 45.8 COG0270@1|root,COG0270@2|Bacteria,1MV9D@1224|Proteobacteria,1RPD1@1236|Gammaproteobacteria,3NIJ8@468|Moraxellaceae 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase dcm - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_469486_1 1121324.CLIT_2c01750 1.05e-18 91.3 COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia 186801|Clostridia C 4Fe-4S binding domain protein - - - - - - - - - - - - Fer4,Fer4_5 k59_435892_1 1168034.FH5T_03525 1.72e-68 221.0 COG3307@1|root,COG3307@2|Bacteria,4NMYT@976|Bacteroidetes 976|Bacteroidetes M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_503191_2 1033802.SSPSH_003276 1.43e-20 96.7 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretory pathway component ExeA - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_175951_1 1265505.ATUG01000001_gene2991 2.38e-48 172.0 COG1578@1|root,COG1578@2|Bacteria,1R50K@1224|Proteobacteria,42Q0S@68525|delta/epsilon subdivisions,2WJ5M@28221|Deltaproteobacteria,2MIQ5@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function DUF89 - - - - - - - - - - - - DUF89 k59_271984_1 641526.ADIWIN_0331 8.63e-06 54.3 COG1345@1|root,COG1345@2|Bacteria,4NGSK@976|Bacteroidetes,1HZ2I@117743|Flavobacteriia 976|Bacteroidetes N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end - - - - - - - - - - - - ASH,TIG k59_698157_1 204773.HEAR1649 0.000305 42.4 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,2VINE@28216|Betaproteobacteria,4747C@75682|Oxalobacteraceae 28216|Betaproteobacteria S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_698157_2 1283300.ATXB01000001_gene1294 8e-85 263.0 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1XEBV@135618|Methylococcales 135618|Methylococcales EGP PFAM Major Facilitator Superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_959440_1 944547.ABLL_1463 1.32e-79 243.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,42Q44@68525|delta/epsilon subdivisions,2YNTJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_959440_2 1172190.M947_00025 2.32e-08 53.1 COG4314@1|root,COG4314@2|Bacteria,1N3G0@1224|Proteobacteria,42SNT@68525|delta/epsilon subdivisions,2YPPG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - - k59_371687_1 1168034.FH5T_06130 2.58e-82 251.0 COG3117@1|root,COG3117@2|Bacteria,4NSXY@976|Bacteroidetes,2G2BC@200643|Bacteroidia 976|Bacteroidetes S Lipopolysaccharide-assembly, LptC-related - - - - - - - - - - - - LptC k59_371687_2 1168034.FH5T_06135 5.12e-81 256.0 COG2956@1|root,COG2956@2|Bacteria,4PNWA@976|Bacteroidetes,2G0ZI@200643|Bacteroidia 976|Bacteroidetes G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane - - - - - - - - - - - - TPR_16 k59_793698_1 391616.OA238_c39840 5.45e-73 226.0 COG0600@1|root,COG0600@2|Bacteria,1N0FV@1224|Proteobacteria,2U1I5@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system permease component - - - ko:K15599 ko02010,map02010 M00442 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.3,3.A.1.17.6 - - BPD_transp_1 k59_77470_1 1408473.JHXO01000008_gene2763 2.57e-60 192.0 COG2928@1|root,COG2928@2|Bacteria,4NR4F@976|Bacteroidetes,2FZVE@200643|Bacteroidia 976|Bacteroidetes S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_143710_1 1168034.FH5T_08635 5.62e-120 346.0 COG0479@1|root,COG0479@2|Bacteria,4NFR3@976|Bacteroidetes,2FP6Q@200643|Bacteroidia 976|Bacteroidetes C Succinate dehydrogenase Fumarate reductase frdB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_7,Fer4_8 k59_403721_1 1283300.ATXB01000002_gene3026 3.29e-62 202.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1XDQ4@135618|Methylococcales 135618|Methylococcales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_339899_1 1049564.TevJSym_bn00080 1.16e-124 367.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1J5P6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_861196_1 485915.Dret_0454 9.79e-73 247.0 COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1NTJT@1224|Proteobacteria,42NK8@68525|delta/epsilon subdivisions,2WIM0@28221|Deltaproteobacteria,2M8SV@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Cytochrome c, class I - - - - - - - - - - - - Cyt_bd_oxida_I,Cytochrome_CBB3 k59_110278_1 1537917.JU82_08310 6.04e-134 385.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2YMXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins iscU - - ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N k59_793702_1 28229.ND2E_1657 2.14e-17 86.3 COG2911@1|root,COG2911@2|Bacteria,1R8QR@1224|Proteobacteria,1RPB5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_927754_1 998674.ATTE01000001_gene3667 5.09e-34 122.0 COG2192@1|root,COG2192@2|Bacteria,1R3MX@1224|Proteobacteria,1T69R@1236|Gammaproteobacteria 1236|Gammaproteobacteria O nodulation - - - - - - - - - - - - - k59_927754_2 402777.KB235903_gene660 1.24e-26 107.0 COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1H9E9@1150|Oscillatoriales 1117|Cyanobacteria O carbamoyl transferase, NodU family - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_861199_1 1232437.KL662063_gene3996 9.03e-64 207.0 COG4565@1|root,COG4963@1|root,COG4565@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,2MJQA@213118|Desulfobacterales 28221|Deltaproteobacteria D AAA domain - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,CBP_BcsQ,ParA,Response_reg k59_305009_1 469610.HMPREF0189_02108 3.91e-69 211.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2VR5R@28216|Betaproteobacteria,1KKPA@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_666374_2 318167.Sfri_2288 1.91e-97 298.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,2QAVG@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k59_894328_1 458817.Shal_1884 1.96e-11 65.9 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,2QDHI@267890|Shewanellaceae 1236|Gammaproteobacteria C Iron-containing alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_894328_2 716928.AJQT01000068_gene3393 9.19e-82 265.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_7513_1 572544.Ilyop_0183 6.99e-49 159.0 COG0194@1|root,COG0194@2|Bacteria,379NK@32066|Fusobacteria 32066|Fusobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_7513_2 572544.Ilyop_0182 2.12e-47 152.0 COG2052@1|root,COG2052@2|Bacteria,37ANU@32066|Fusobacteria 32066|Fusobacteria S Belongs to the UPF0296 family - - - ko:K09777 - - - - ko00000 - - - DUF370 k59_7513_3 469616.FMAG_02456 1.46e-13 68.9 COG1561@1|root,COG1561@2|Bacteria,379A0@32066|Fusobacteria 32066|Fusobacteria S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N k59_763138_2 1348114.OM33_00455 9.55e-20 88.6 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,2PZUM@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iYL1228.KPN_04440 Ala_racemase_C,Ala_racemase_N k59_175992_1 522306.CAP2UW1_1756 2.33e-20 91.3 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJ1B@28216|Betaproteobacteria 28216|Betaproteobacteria M RND efflux system, outer membrane lipoprotein - - - - - - - - - - - - OEP k59_600679_1 1167006.UWK_00072 5.77e-113 348.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MJ2X@213118|Desulfobacterales 28221|Deltaproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_600679_2 1267003.KB911368_gene180 1.62e-59 203.0 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H9KA@91061|Bacilli,3F490@33958|Lactobacillaceae 91061|Bacilli O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_339924_1 1121451.DESAM_22094 4.66e-31 127.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42MXI@68525|delta/epsilon subdivisions,2X222@28221|Deltaproteobacteria,2M8BY@213115|Desulfovibrionales 28221|Deltaproteobacteria T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,PAS_4,dCache_1 k59_143734_1 199310.c4878 3.49e-81 257.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,3XN2R@561|Escherichia 1236|Gammaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019405,GO:0019563,GO:0019751,GO:0033554,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901575,GO:1901615,GO:1901616 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - iE2348C_1286.E2348C_4230,iECNA114_1301.ECNA114_4065,iECSF_1327.ECSF_3786 FGGY_C,FGGY_N k59_729991_1 1168034.FH5T_02905 2.49e-124 370.0 COG1524@1|root,COG1524@2|Bacteria,4NE94@976|Bacteroidetes,2FMQC@200643|Bacteroidia 976|Bacteroidetes P type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_208548_1 1033743.CAES01000048_gene784 0.000378 43.1 COG0735@1|root,COG0735@2|Bacteria,1V7F0@1239|Firmicutes,4HH78@91061|Bacilli,26R8X@186822|Paenibacillaceae 91061|Bacilli P Belongs to the Fur family fur GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_305028_1 522306.CAP2UW1_3983 1.63e-91 279.0 COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,2VMFB@28216|Betaproteobacteria 28216|Betaproteobacteria M FtsX-like permease family - - - - - - - - - - - - FtsX k59_959453_1 1229276.DI53_0253 1.97e-39 143.0 COG0149@1|root,COG0149@2|Bacteria,4NE2F@976|Bacteroidetes,1IPGF@117747|Sphingobacteriia 976|Bacteroidetes G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_959453_2 1410668.JNKC01000001_gene1527 1.75e-66 206.0 COG0698@1|root,COG0698@2|Bacteria,1V6HS@1239|Firmicutes,24J8M@186801|Clostridia,36JXA@31979|Clostridiaceae 186801|Clostridia G ribose 5-phosphate isomerase B - - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_959453_3 339671.Asuc_1596 4.49e-159 456.0 28H7K@1|root,2Z7JT@2|Bacteria,1MV01@1224|Proteobacteria,1RSNP@1236|Gammaproteobacteria,1Y8A1@135625|Pasteurellales 135625|Pasteurellales U 2-keto-3-deoxygluconate permease - - - ko:K02526 - - - - ko00000,ko02000 2.A.10.1 - - KdgT k59_959453_4 97138.C820_01293 7.84e-157 455.0 COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,36FK7@31979|Clostridiaceae 186801|Clostridia G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_959453_6 572544.Ilyop_1483 1.84e-155 444.0 COG3958@1|root,COG3958@2|Bacteria,378ZW@32066|Fusobacteria 32066|Fusobacteria G Psort location Cytoplasmic, score - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_600698_1 1165841.SULAR_09399 3.33e-94 296.0 COG1262@1|root,COG1352@1|root,COG1262@2|Bacteria,COG1352@2|Bacteria,1MUNC@1224|Proteobacteria,42N4Y@68525|delta/epsilon subdivisions,2YNCE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - DinB_2,FGE-sulfatase,Methyltransf_11,Methyltransf_31 k59_959458_1 1049564.TevJSym_aj00120 8.22e-61 202.0 COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S6AN@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT phosphohydrolase rela3 - - - - - - - - - - - HD_4 k59_861233_1 439235.Dalk_4509 2.21e-52 176.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,434AT@68525|delta/epsilon subdivisions,2X9GM@28221|Deltaproteobacteria,2MNQ4@213118|Desulfobacterales 28221|Deltaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_666401_1 314278.NB231_00215 2.57e-79 245.0 COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1S5ED@1236|Gammaproteobacteria 1236|Gammaproteobacteria C phenol hydroxylase poxF - - - - - - - - - - - FAD_binding_6,NAD_binding_1 k59_927787_1 1042326.AZNV01000051_gene1272 4.58e-24 108.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS_4,PAS_9 k59_77501_1 1168034.FH5T_04190 1.37e-53 173.0 COG0081@1|root,COG0081@2|Bacteria,4NEIC@976|Bacteroidetes,2FNKI@200643|Bacteroidia 976|Bacteroidetes J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_77501_2 1168034.FH5T_04185 6.73e-95 279.0 COG0244@1|root,COG0244@2|Bacteria,4NFFK@976|Bacteroidetes,2FSBB@200643|Bacteroidia 976|Bacteroidetes J Ribosomal protein L10 rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_77501_3 985255.APHJ01000025_gene1043 3.92e-55 175.0 COG0222@1|root,COG0222@2|Bacteria,4NQAQ@976|Bacteroidetes,1I1Y0@117743|Flavobacteriia,2P6TX@244698|Gillisia 976|Bacteroidetes J Ribosomal protein L7/L12 dimerisation domain rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_568006_1 471870.BACINT_00979 4.84e-166 497.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FM2D@200643|Bacteroidia,4AK7X@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_992942_1 1123400.KB904758_gene2205 6.55e-90 274.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,1RP2I@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0798 Arsenite efflux pump ACR3 and related permeases arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_403762_1 1232410.KI421421_gene3858 6.37e-45 166.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,43TBV@69541|Desulfuromonadales 28221|Deltaproteobacteria M PASTA domain ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_305050_1 998674.ATTE01000001_gene4115 1.66e-95 293.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,460BC@72273|Thiotrichales 72273|Thiotrichales Q transporter, dctM subunit - - - - - - - - - - - - DctM k59_861666_44 457421.CBFG_01532 1.26e-53 205.0 COG5283@1|root,COG5283@2|Bacteria,1UVPX@1239|Firmicutes,25P02@186801|Clostridia,26A1X@186813|unclassified Clostridiales 186801|Clostridia S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_861666_47 944547.ABLL_1888 6.12e-35 136.0 COG3500@1|root,COG3500@2|Bacteria,1MXT8@1224|Proteobacteria,42U7Z@68525|delta/epsilon subdivisions,2YPVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Phage late control gene D protein (GPD) - - - ko:K06905 - - - - ko00000 - - - Phage_GPD k59_861666_49 749222.Nitsa_1766 2.84e-38 139.0 COG3409@1|root,COG3409@2|Bacteria,1R4RS@1224|Proteobacteria 1224|Proteobacteria M CHAP domain - - - - - - - - - - - - CHAP,PG_binding_1 k59_861666_52 1448857.JFAP01000008_gene631 9.25e-90 274.0 COG0338@1|root,COG0338@2|Bacteria,1P85S@1224|Proteobacteria,42MJQ@68525|delta/epsilon subdivisions,2YNDD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA methyltransferase dam - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_895046_1 526218.Sterm_2402 1.25e-40 142.0 COG1091@1|root,COG1091@2|Bacteria,37946@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind,dTDP_sugar_isom k59_895046_2 1321779.HMPREF1984_01161 2.37e-81 254.0 COG1088@1|root,COG1088@2|Bacteria,378J0@32066|Fusobacteria 32066|Fusobacteria M Psort location Cytoplasmic, score rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_372292_1 472759.Nhal_2510 4.72e-42 148.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales 135613|Chromatiales C PFAM Alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_372292_2 395493.BegalDRAFT_1700 1.83e-15 74.7 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,46076@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 4.1.3.30 ko:K03417 ko00640,map00640 - R00409 RC00286,RC00287 ko00000,ko00001,ko01000 - - - PEP_mutase k59_634048_1 1286632.P278_22040 2.26e-76 235.0 COG2025@1|root,COG2025@2|Bacteria,4NFSE@976|Bacteroidetes,1HX9P@117743|Flavobacteriia 976|Bacteroidetes C Electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_209183_1 709032.Sulku_1510 1.96e-64 209.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,42MHB@68525|delta/epsilon subdivisions,2YNUZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase cofactor biosynthesis protein NifB - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_209183_2 1249480.B649_06590 4.62e-191 539.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YNBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_305717_1 1168034.FH5T_07405 1.34e-131 402.0 COG0038@1|root,COG0038@2|Bacteria,4NZYS@976|Bacteroidetes,2G0DB@200643|Bacteroidia 976|Bacteroidetes P Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 k59_895050_1 439235.Dalk_1635 2.92e-06 49.7 COG2043@1|root,COG2043@2|Bacteria,1NR18@1224|Proteobacteria,42TWC@68525|delta/epsilon subdivisions,2WQ80@28221|Deltaproteobacteria,2MMHB@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 k59_895050_2 1120963.KB894491_gene654 1.03e-49 174.0 COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,2Q0M6@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria C Na H antiporter nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k59_895052_1 883126.HMPREF9710_04170 4.24e-09 57.0 COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,2VJW7@28216|Betaproteobacteria,472BA@75682|Oxalobacteraceae 28216|Betaproteobacteria S Virulence factor BrkB - - - - - - - - - - - - Virul_fac_BrkB k59_895052_2 1121943.KB900004_gene2913 2.58e-26 101.0 COG0695@1|root,COG0695@2|Bacteria 2|Bacteria O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - ko:K06191 - - - - ko00000 - - - GST_N_3,Glutaredoxin k59_144423_1 572477.Alvin_1892 5.23e-78 243.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1WWNS@135613|Chromatiales 135613|Chromatiales I TIGRFAM malonyl CoA-acyl carrier protein transacylase - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_698860_2 765911.Thivi_0089 1.11e-33 127.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1WXI9@135613|Chromatiales 135613|Chromatiales P PFAM sodium calcium exchanger - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_372302_1 555779.Dthio_PD3802 4.01e-69 250.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_928444_1 311402.Avi_3171 1.7e-31 122.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,4B8EB@82115|Rhizobiaceae 28211|Alphaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_829566_1 1288494.EBAPG3_26320 2.25e-70 239.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales 28216|Betaproteobacteria IQ AMP-dependent synthetase - - - - - - - - - - - - AMP-binding,Acyltransferase,PP-binding k59_176721_1 506534.Rhein_2695 2.98e-90 280.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1WWIB@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1025120_1 153721.MYP_4724 2.26e-42 152.0 COG1708@1|root,COG2250@1|root,COG1708@2|Bacteria,COG2250@2|Bacteria,4NNCW@976|Bacteroidetes,47Q96@768503|Cytophagia 976|Bacteroidetes S HEPN domain - - - - - - - - - - - - HEPN k59_763859_1 1168034.FH5T_12135 1.47e-66 206.0 COG0009@1|root,COG0009@2|Bacteria,4NDZR@976|Bacteroidetes,2FP9A@200643|Bacteroidia 976|Bacteroidetes J Belongs to the SUA5 family yciO - - - - - - - - - - - Sua5_yciO_yrdC k59_763859_2 1121007.AUML01000018_gene482 0.000119 43.9 COG4121@1|root,COG4121@2|Bacteria,4NE5S@976|Bacteroidetes,1HZG3@117743|Flavobacteriia,2YGU8@290174|Aquimarina 976|Bacteroidetes S S-adenosyl-L-methionine-dependent methyltransferase mnmC - - - - - - - - - - - Methyltransf_30 k59_272587_1 439235.Dalk_3943 8.23e-82 273.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2MJ8R@213118|Desulfobacterales 28221|Deltaproteobacteria CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh k59_1025127_1 1168034.FH5T_12625 3.97e-68 216.0 COG0111@1|root,COG0111@2|Bacteria,4PMZ0@976|Bacteroidetes,2G0M0@200643|Bacteroidia 976|Bacteroidetes EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_43532_1 1537917.JU82_00600 8.08e-137 394.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2YN4V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_829583_1 1444309.JAQG01000073_gene269 1.28e-70 238.0 COG1643@1|root,COG1643@2|Bacteria,1TPET@1239|Firmicutes,4HE8W@91061|Bacilli,26U7B@186822|Paenibacillaceae 91061|Bacilli L ATP-dependent helicase hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_78002_1 1049564.TevJSym_bd00010 6.07e-52 169.0 COG3439@1|root,COG3439@2|Bacteria,1RA8I@1224|Proteobacteria,1S34D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_895080_1 1337936.IJ00_26720 1.22e-43 161.0 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_3,Pkinase k59_928461_1 518766.Rmar_1392 6.36e-46 164.0 COG2317@1|root,COG2317@2|Bacteria,4NK5Q@976|Bacteroidetes,1FISH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 k59_1025136_1 870187.Thini_3852 5.16e-58 191.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,45ZWU@72273|Thiotrichales 72273|Thiotrichales E TIGRFAM KamA family protein epmB - - ko:K19810 - - - - ko00000,ko01000,ko03012 - - - Fer4_12,Fer4_14,Radical_SAM k59_7939_1 1249480.B649_10065 2e-25 107.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2YMF0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM Polysaccharide biosynthesis protein pglF - 4.2.1.135 ko:K15912 ko00520,map00520 - - - ko00000,ko00001,ko01000 - - - Polysacc_synt_2 k59_7939_2 1537915.JU57_08000 1.61e-45 159.0 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,42QJJ@68525|delta/epsilon subdivisions,2YTPK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M glycosyl transferase - - - ko:K13007 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_568590_1 765910.MARPU_13525 6.41e-90 278.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales 135613|Chromatiales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_43537_1 572544.Ilyop_0809 3.68e-96 287.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity - - - - - - - - - - - - Epimerase k59_404409_1 1165841.SULAR_05848 4.56e-73 230.0 COG2515@1|root,COG2515@2|Bacteria,1R87T@1224|Proteobacteria,42MPC@68525|delta/epsilon subdivisions,2YN3K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E 1-aminocyclopropane-1-carboxylate deaminase acd - 3.5.99.7 ko:K01505 ko00270,map00270 - R00997 RC00419 ko00000,ko00001,ko01000 - - - - k59_634098_1 1168034.FH5T_13400 1.01e-165 503.0 COG2199@1|root,COG3292@1|root,COG5002@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,4NK8Q@976|Bacteroidetes,2FXT6@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_78014_1 317025.Tcr_1603 2.51e-61 201.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,1RQYE@1236|Gammaproteobacteria,45ZWE@72273|Thiotrichales 72273|Thiotrichales M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1025143_1 404589.Anae109_1281 1.09e-56 201.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2YWE3@29|Myxococcales 28221|Deltaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_568604_1 765911.Thivi_1808 1.12e-77 239.0 COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,1RP5T@1236|Gammaproteobacteria,1WWHE@135613|Chromatiales 135613|Chromatiales L hydrolase, TatD family - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_78019_1 563040.Saut_0929 5.05e-28 114.0 2A07G@1|root,30NAN@2|Bacteria,1Q58X@1224|Proteobacteria,430TB@68525|delta/epsilon subdivisions,2YRYC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_78019_2 563040.Saut_0930 3.91e-67 211.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42QPE@68525|delta/epsilon subdivisions,2YRPR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_305778_1 755731.Clo1100_3855 8.28e-28 116.0 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,36DDZ@31979|Clostridiaceae 186801|Clostridia C PFAM ferredoxin - - - - - - - - - - - - DUF4445,Fer2 k59_43554_1 1026882.MAMP_00661 7.07e-20 90.9 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,45ZQE@72273|Thiotrichales 72273|Thiotrichales M Belongs to the peptidase S1C family - - - ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_43554_2 323261.Noc_1573 5.28e-54 175.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_305785_1 387093.SUN_2048 9.14e-95 285.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2YMMA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iIT341.HP0202 ACP_syn_III,ACP_syn_III_C k59_667135_1 1049564.TevJSym_ak00590 6.6e-177 509.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1J5IS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_176771_1 385682.AFSL01000012_gene2802 4.4e-43 148.0 COG0492@1|root,COG0492@2|Bacteria,4PMJ9@976|Bacteroidetes,2G0D7@200643|Bacteroidia,3XJU4@558415|Marinilabiliaceae 976|Bacteroidetes O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Glutaredoxin,Pyr_redox_2 k59_176771_2 1168034.FH5T_19040 2.81e-60 187.0 2BA0I@1|root,33ZZV@2|Bacteria,4P4SG@976|Bacteroidetes,2FYDD@200643|Bacteroidia 976|Bacteroidetes - - - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - - k59_209246_1 1408473.JHXO01000002_gene3989 5.24e-09 55.8 COG2020@1|root,COG2020@2|Bacteria,4NXS4@976|Bacteroidetes 976|Bacteroidetes O Methyltransferase - - - - - - - - - - - - ICMT,PEMT k59_698923_2 1232437.KL662047_gene5203 1.65e-29 118.0 COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria,2MJBB@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM DAHP synthetase I - - 2.5.1.54,5.4.99.5 ko:K03856,ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,DAHP_synth_1,PDT k59_763912_1 572544.Ilyop_0521 1.39e-22 90.1 COG1051@1|root,COG1051@2|Bacteria 2|Bacteria F GDP-mannose mannosyl hydrolase activity apfA - 2.7.7.72,3.6.1.55,3.6.1.61 ko:K00974,ko:K03574,ko:K18445 ko00230,ko03013,map00230,map03013 - R00184,R09382,R09383,R09384,R09386 RC00002,RC00078 ko00000,ko00001,ko01000,ko03016,ko03400 - - - NUDIX k59_763912_2 572544.Ilyop_0520 2.79e-88 278.0 COG0556@1|root,COG0556@2|Bacteria,3783F@32066|Fusobacteria 32066|Fusobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_305791_1 293826.Amet_0651 2.49e-09 60.8 COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,36JKN@31979|Clostridiaceae 186801|Clostridia F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CM_2,SKI k59_698929_1 870187.Thini_1771 1.06e-63 214.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,462AI@72273|Thiotrichales 72273|Thiotrichales P PFAM von Willebrand factor type A domain - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - - k59_763916_2 572544.Ilyop_1341 2.16e-52 168.0 COG5496@1|root,COG5496@2|Bacteria,37A4J@32066|Fusobacteria 32066|Fusobacteria S Thioesterase - - - - - - - - - - - - 4HBT k59_763916_3 469618.FVAG_02047 1.34e-80 251.0 COG2233@1|root,COG2233@2|Bacteria,378C9@32066|Fusobacteria 32066|Fusobacteria F Permease family pyrP - - ko:K02824 - - - - ko00000,ko02000 2.A.40.1.1,2.A.40.1.2 - - Xan_ur_permease k59_340675_1 452637.Oter_4539 6.24e-77 241.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 k59_110847_1 469616.FMAG_00296 1.61e-98 291.0 COG0463@1|root,COG0463@2|Bacteria,378X8@32066|Fusobacteria 32066|Fusobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_110847_2 762983.HMPREF9444_00947 3.46e-38 144.0 COG1807@1|root,COG1807@2|Bacteria,1MXH5@1224|Proteobacteria,1RSQE@1236|Gammaproteobacteria,1Y6F2@135624|Aeromonadales 135624|Aeromonadales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_601467_1 529507.PMI1233 0.000168 43.5 COG0329@1|root,COG0329@2|Bacteria,1R4AY@1224|Proteobacteria,1RRPJ@1236|Gammaproteobacteria,3Z1EX@583|Proteus 1236|Gammaproteobacteria EM Dihydrodipicolinate synthetase family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_634139_1 1278306.KB906912_gene881 1.23e-152 445.0 COG0554@1|root,COG0554@2|Bacteria,3799Z@32066|Fusobacteria 32066|Fusobacteria H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_176786_1 1168034.FH5T_01745 5.49e-57 187.0 COG0019@1|root,COG0019@2|Bacteria,4NEN0@976|Bacteroidetes 976|Bacteroidetes E carboxynorspermidine decarboxylase nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_176786_2 1168034.FH5T_01740 2.85e-77 240.0 COG1748@1|root,COG1748@2|Bacteria,4NE0Y@976|Bacteroidetes,2FMKT@200643|Bacteroidia 976|Bacteroidetes E Saccharopine dehydrogenase LYS1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_144499_1 930169.B5T_04183 6.38e-118 349.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XI6M@135619|Oceanospirillales 135619|Oceanospirillales P Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_568627_1 1121904.ARBP01000011_gene1465 2.12e-102 324.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47JGB@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_536414_1 1234364.AMSF01000046_gene1983 2.07e-31 122.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1X37F@135614|Xanthomonadales 135614|Xanthomonadales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF k59_634653_7 765912.Thimo_1200 2.41e-104 304.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,1RPVD@1236|Gammaproteobacteria,1WWME@135613|Chromatiales 135613|Chromatiales C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_634653_8 1049564.TevJSym_aa01800 2.23e-242 675.0 COG1055@1|root,COG1055@2|Bacteria 2|Bacteria P arsenite transmembrane transporter activity - - - - - - - - - - - - CitMHS k59_634653_9 1121935.AQXX01000140_gene1049 2.49e-68 216.0 COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_634653_10 1238182.C882_1544 1.62e-05 55.8 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2U6VB@28211|Alphaproteobacteria,2JZAR@204441|Rhodospirillales 204441|Rhodospirillales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_634653_13 765914.ThisiDRAFT_2078 6.71e-222 634.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_634653_14 1049564.TevJSym_at00760 4.16e-94 290.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1J5F2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_862307_1 1197477.IA57_00005 5.35e-44 162.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - - - - - - - - - - CHU_C,DUF11,SdrD_B,VWA,VWA_2 k59_8308_2 1353537.TP2_15325 1.1e-40 136.0 COG1359@1|root,COG1359@2|Bacteria 2|Bacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_8308_3 483218.BACPEC_01469 6.83e-86 254.0 COG0537@1|root,COG0537@2|Bacteria,1V3BE@1239|Firmicutes,24H73@186801|Clostridia,26B5N@186813|unclassified Clostridiales 186801|Clostridia FG HIT domain - - - - - - - - - - - - HIT k59_8308_4 4555.Si024215m 5.96e-11 63.9 COG4677@1|root,2QTUS@2759|Eukaryota,37HK8@33090|Viridiplantae,3G751@35493|Streptophyta,3KUI0@4447|Liliopsida,3IA11@38820|Poales 35493|Streptophyta G Pectinesterase - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0030312,GO:0044424,GO:0044464,GO:0071944 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pectinesterase k59_504699_1 1304883.KI912532_gene308 0.000172 44.7 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2VU5R@28216|Betaproteobacteria,2KWK1@206389|Rhodocyclales 206389|Rhodocyclales L COG0350 Methylated DNA-protein cysteine methyltransferase - - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1 k59_699466_1 1123326.JFBL01000001_gene1523 4.38e-15 70.9 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,42SI7@68525|delta/epsilon subdivisions,2YP7Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0178 family - - - ko:K09768 - - - - ko00000 - - - DUF188 k59_699466_2 929558.SMGD1_1140 8.33e-132 389.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YNK5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DEAD box helicase family dbpA - 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C k59_273135_1 1485545.JQLW01000005_gene1039 1.29e-22 91.3 COG1495@1|root,COG1495@2|Bacteria,1N2C1@1224|Proteobacteria 1224|Proteobacteria O Belongs to the DsbB family bdbC - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_273135_2 1240350.AMZE01000015_gene4033 9.2e-07 50.4 COG2050@1|root,COG2050@2|Bacteria,1NHB0@1224|Proteobacteria,1T057@1236|Gammaproteobacteria,1YWXP@136845|Pseudomonas putida group 1236|Gammaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_536983_1 1047013.AQSP01000077_gene2271 1.07e-22 100.0 COG3876@1|root,COG3876@2|Bacteria,2NNRQ@2323|unclassified Bacteria 2|Bacteria S PFAM Uncharacterised conserved protein UCP016719 ybbC - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - DUF1343 k59_1025733_1 1095769.CAHF01000022_gene248 7.54e-77 240.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2VJ31@28216|Betaproteobacteria,474PP@75682|Oxalobacteraceae 28216|Betaproteobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_994192_1 243233.MCA1214 1.03e-166 484.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XDS9@135618|Methylococcales 135618|Methylococcales V ABC transporter transmembrane region - - - ko:K06147,ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_862322_1 864073.HFRIS_010449 8.23e-125 385.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,472J4@75682|Oxalobacteraceae 28216|Betaproteobacteria C E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_830165_1 1049564.TevJSym_aj00800 7.71e-77 234.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria,1J9UJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - ko:K00184,ko:K21308 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 5.A.3 - - Fer4_11,Fer4_4,Fer4_7,Molydop_binding k59_830165_2 1049564.TevJSym_aj00790 3.17e-15 73.9 COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,1RS3Q@1236|Gammaproteobacteria,1JB7K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S DMSO reductase anchor subunit (DmsC) dmsC - - ko:K21309 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - DmsC k59_341262_1 742733.HMPREF9469_02650 3.44e-54 181.0 COG0583@1|root,COG0583@2|Bacteria,1UZ63@1239|Firmicutes,24BVU@186801|Clostridia,21Z1M@1506553|Lachnoclostridium 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_273143_1 4155.Migut.A01228.1.p 2.85e-72 220.0 2BG5J@1|root,2S18N@2759|Eukaryota,37UMK@33090|Viridiplantae,3GJ5T@35493|Streptophyta,44TQ8@71274|asterids 35493|Streptophyta - - - - - - - - - - - - - - - k59_78470_1 29760.VIT_01s0011g03940.t01 5.33e-23 88.6 28R37@1|root,2QXS9@2759|Eukaryota,389W9@33090|Viridiplantae,3GMPR@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_177423_1 580332.Slit_2979 5.65e-59 197.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,44V20@713636|Nitrosomonadales 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_667761_1 159087.Daro_2370 1.75e-63 206.0 COG4990@1|root,COG4990@2|Bacteria,1MVC4@1224|Proteobacteria,2VJT2@28216|Betaproteobacteria,2KUHT@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4872) - - - - - - - - - - - - BtrH_N,DUF4872 k59_569119_1 1042377.AFPJ01000007_gene1780 3.79e-54 178.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,466EF@72275|Alteromonadaceae 1236|Gammaproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_1025748_1 1235788.C802_03429 4.58e-06 54.7 COG2755@1|root,COG4677@1|root,COG2755@2|Bacteria,COG4677@2|Bacteria,4NEEI@976|Bacteroidetes,2FMFM@200643|Bacteroidia,4AKQF@815|Bacteroidaceae 976|Bacteroidetes EG Psort location Extracellular, score rhgT_2 - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Lipase_GDSL_2,Pectinesterase k59_830177_1 768671.ThimaDRAFT_1443 2.16e-84 259.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,1WW4N@135613|Chromatiales 135613|Chromatiales C PFAM aldo keto reductase tas - - - - - - - - - - - Aldo_ket_red k59_895801_1 1198232.CYCME_0406 2.06e-93 294.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,4603K@72273|Thiotrichales 72273|Thiotrichales O magnesium chelatase - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_306395_1 301.JNHE01000006_gene1177 4.61e-21 97.4 2BCPH@1|root,3269T@2|Bacteria,1RJN1@1224|Proteobacteria,1S744@1236|Gammaproteobacteria,1YGM2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Domain of unknown function (DUF4824) - - - - - - - - - - - - DUF4824 k59_306395_2 870187.Thini_4014 6.88e-21 85.9 2E4UR@1|root,32ZP4@2|Bacteria,1N83W@1224|Proteobacteria,1SEK3@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_306395_3 1249627.D779_1707 1.44e-95 286.0 COG1433@1|root,COG1433@2|Bacteria,1PW6J@1224|Proteobacteria,1S0X4@1236|Gammaproteobacteria,1WW14@135613|Chromatiales 135613|Chromatiales S PFAM Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - DIMCO_N,Nitro_FeMo-Co k59_306395_4 768671.ThimaDRAFT_1259 1.3e-33 116.0 COG5554@1|root,COG5554@2|Bacteria,1N7DQ@1224|Proteobacteria,1SD1T@1236|Gammaproteobacteria,1WYZ7@135613|Chromatiales 135613|Chromatiales Q PFAM NifT FixU - - - ko:K02593 - - - - ko00000 - - - NifT k59_306395_5 870187.Thini_4010 0.0 934.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,1RMV3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation nifK - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_306395_6 765911.Thivi_3648 0.0 892.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,1RSFD@1236|Gammaproteobacteria,1WWPP@135613|Chromatiales 135613|Chromatiales C Nitrogenase molybdenum-iron protein alpha chain - - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_306395_7 1122201.AUAZ01000022_gene3082 7.47e-191 533.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,1RR82@1236|Gammaproteobacteria,466BC@72275|Alteromonadaceae 1236|Gammaproteobacteria D The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_306395_8 1249627.D779_1713 9.41e-118 346.0 28IJT@1|root,2Z8KN@2|Bacteria,1R6VB@1224|Proteobacteria,1RNYB@1236|Gammaproteobacteria,1WW5I@135613|Chromatiales 135613|Chromatiales H PFAM Dinitrogenase reductase ADP-ribosyltransferase - - 2.4.2.37 ko:K05951 - - - - ko00000,ko01000 - - - DRAT k59_306395_9 768671.ThimaDRAFT_3056 8.07e-144 413.0 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,1RNYE@1236|Gammaproteobacteria,1WW73@135613|Chromatiales 135613|Chromatiales S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_306395_11 403833.Pmob_1047 1.07e-21 103.0 COG0535@1|root,COG0535@2|Bacteria,2GCP0@200918|Thermotogae 200918|Thermotogae C Radical SAM - - - ko:K06139 - - - - ko00000 - - - Radical_SAM,SPASM k59_306395_12 641149.HMPREF9016_01290 5.7e-25 95.9 2CHW3@1|root,32S6N@2|Bacteria,1N0I3@1224|Proteobacteria,2VW65@28216|Betaproteobacteria,2KRZK@206351|Neisseriales 206351|Neisseriales S Pathogenicity locus - - - - - - - - - - - - Cdd1 k59_306395_14 1304885.AUEY01000012_gene1777 7.96e-72 222.0 COG0500@1|root,COG2226@2|Bacteria,1N3WC@1224|Proteobacteria,42URQ@68525|delta/epsilon subdivisions,2WQGW@28221|Deltaproteobacteria,2MKH6@213118|Desulfobacterales 28221|Deltaproteobacteria Q FtsJ-like methyltransferase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_306395_15 338963.Pcar_2088 5.98e-62 196.0 COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,42T7R@68525|delta/epsilon subdivisions,2WNQ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria DJ family UPF0066 - - - - - - - - - - - - UPF0066 k59_306395_16 436114.SYO3AOP1_0124 3.85e-33 140.0 COG2199@1|root,COG3706@2|Bacteria,2G51D@200783|Aquificae 200783|Aquificae T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_306395_17 90814.KL370891_gene1376 1.58e-17 75.9 2E5S4@1|root,330GM@2|Bacteria,1NAY4@1224|Proteobacteria,1SEIX@1236|Gammaproteobacteria,4639K@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_731194_1 1229520.ADIAL_1322 3.16e-23 106.0 COG5438@1|root,COG5438@2|Bacteria,1TPEV@1239|Firmicutes,4HCP3@91061|Bacilli,27GTG@186828|Carnobacteriaceae 91061|Bacilli S YibE/F-like protein yibE - - - - - - - - - - - YibE_F k59_731194_3 1123008.KB905716_gene3645 3.28e-49 169.0 COG0428@1|root,COG0428@2|Bacteria,4NT7J@976|Bacteroidetes,2FWBB@200643|Bacteroidia,22ZZK@171551|Porphyromonadaceae 976|Bacteroidetes P ZIP Zinc transporter - - - - - - - - - - - - Zip k59_731194_4 690850.Desaf_3749 2.98e-26 110.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,2M8GB@213115|Desulfovibrionales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C_2,TruB_N k59_699506_1 1174528.JH992888_gene279 1.76e-122 366.0 COG2801@1|root,COG2801@2|Bacteria,1G227@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Integrase core domain - - - - - - - - - - - - rve k59_960907_1 1316927.ATKI01000147_gene971 4.67e-25 107.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria,1YPWG@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria L DNA repair imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_602110_3 1279019.ARQK01000049_gene42 3.15e-38 140.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1WXMF@135613|Chromatiales 135613|Chromatiales O PFAM Thioredoxin - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_111377_1 1148.1653921 3.48e-36 131.0 COG0500@1|root,COG0500@2|Bacteria,1G4ZC@1117|Cyanobacteria 1117|Cyanobacteria Q Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25 k59_111377_2 563040.Saut_0011 8.94e-108 315.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2YNXJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H protein-L-isoaspartate O-methyltransferase pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_78508_1 765913.ThidrDRAFT_0118 1.33e-36 136.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1WXE8@135613|Chromatiales 135613|Chromatiales S PFAM Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_78508_2 572477.Alvin_2888 5.62e-59 197.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1WVY3@135613|Chromatiales 135613|Chromatiales S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_569148_1 326297.Sama_1463 5.43e-76 240.0 COG3203@1|root,COG3203@2|Bacteria,1QYZC@1224|Proteobacteria,1T3Y7@1236|Gammaproteobacteria,2Q951@267890|Shewanellaceae 1236|Gammaproteobacteria M outer membrane porin, OprD family - - - - - - - - - - - - OprD k59_8349_1 396588.Tgr7_2744 5.16e-73 239.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_209935_1 3711.Bra014801.1-P 1.62e-62 210.0 COG1249@1|root,KOG0405@2759|Eukaryota,37KY5@33090|Viridiplantae,3GFPX@35493|Streptophyta,3HNXB@3699|Brassicales 35493|Streptophyta Q Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family GR GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009636,GO:0009987,GO:0010035,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097159,GO:0097237,GO:0097367,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1901700,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_830211_1 1168034.FH5T_11320 5e-101 298.0 COG2339@1|root,COG2339@2|Bacteria,4NGUS@976|Bacteroidetes,2FVBX@200643|Bacteroidia 976|Bacteroidetes S Protease prsW family - - - - - - - - - - - - PrsW-protease k59_830211_2 1168034.FH5T_11315 1.91e-09 57.4 COG3386@1|root,COG3386@2|Bacteria,4NMJX@976|Bacteroidetes,2FRZF@200643|Bacteroidia 976|Bacteroidetes G SMP-30/Gluconolaconase/LRE-like region - - - ko:K14274 ko00040,map00040 - R02427 RC00713 ko00000,ko00001,ko01000 - - - SGL k59_1025791_1 1122603.ATVI01000006_gene90 5.98e-88 278.0 COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,1RS2Q@1236|Gammaproteobacteria,1X3UN@135614|Xanthomonadales 135614|Xanthomonadales E Angiotensin-converting enzyme - - 3.4.15.1 ko:K01283 ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - Peptidase_M2 k59_470315_1 190486.XAC3602 7.74e-78 244.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1X4AH@135614|Xanthomonadales 135614|Xanthomonadales E cystathionine - - 4.4.1.1 ko:K01758 ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230 M00338 R00782,R01001,R02408,R04770,R04930,R09366 RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_8357_1 768671.ThimaDRAFT_1370 2.75e-95 290.0 COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,1RSDK@1236|Gammaproteobacteria,1WVUU@135613|Chromatiales 135613|Chromatiales O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_145106_1 1123057.P872_02000 8.46e-45 160.0 COG4409@1|root,COG4409@2|Bacteria,4NI5M@976|Bacteroidetes,47JYZ@768503|Cytophagia 976|Bacteroidetes G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - BNR_2 k59_504792_1 1049564.TevJSym_ah00950 4.14e-55 190.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_569165_1 391038.Bphy_2066 5.61e-103 305.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,1K0ZV@119060|Burkholderiaceae 28216|Betaproteobacteria H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_437238_1 391615.ABSJ01000051_gene1118 2.78e-71 230.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1J54Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_994258_1 469617.FUAG_02175 2.2e-82 264.0 COG0420@1|root,COG0420@2|Bacteria,378KS@32066|Fusobacteria 32066|Fusobacteria L Calcineurin-like phosphoesterase superfamily domain sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos k59_929116_1 871968.DESME_13010 1.25e-45 167.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,260B9@186807|Peptococcaceae 186801|Clostridia G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_373587_1 1444712.BN1013_00566 0.000152 43.1 COG3360@1|root,COG3360@2|Bacteria 2|Bacteria P Dodecin secE2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K09165 - - - - ko00000 - - - Dodecin k59_373587_2 1132855.KB913035_gene1890 4.78e-22 90.1 COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,2VTSY@28216|Betaproteobacteria,2KMTG@206350|Nitrosomonadales 206350|Nitrosomonadales M Lipocalin-like domain - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_210750_1 1123227.KB899338_gene1065 5.26e-58 197.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria,2JSYH@204441|Rhodospirillales 204441|Rhodospirillales S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_307225_1 1165841.SULAR_07380 6.13e-68 226.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,42PUG@68525|delta/epsilon subdivisions,2YN09@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB-dependent copper receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_178299_1 1168289.AJKI01000016_gene1949 7.47e-125 368.0 COG2211@1|root,COG2211@2|Bacteria,4NE3B@976|Bacteroidetes,2FPMF@200643|Bacteroidia,3XIS3@558415|Marinilabiliaceae 976|Bacteroidetes G MFS/sugar transport protein uidB - - ko:K03292 - - - - ko00000 2.A.2 - - Glyco_hydro_17,MFS_2 k59_273829_1 1408437.JNJN01000005_gene1895 3.33e-114 346.0 COG4146@1|root,COG4146@2|Bacteria,1UHPR@1239|Firmicutes,25HI4@186801|Clostridia,25ZMP@186806|Eubacteriaceae 1239|Firmicutes S Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_961737_2 1319815.HMPREF0202_02988 1.44e-112 326.0 arCOG05185@1|root,2Z9G9@2|Bacteria,37BMM@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_307229_1 316273.XCV2599 1.06e-38 136.0 COG5394@1|root,COG5394@2|Bacteria,1RFY3@1224|Proteobacteria,1S3W3@1236|Gammaproteobacteria,1X66E@135614|Xanthomonadales 135614|Xanthomonadales S synthesis repressor, PhaR phaR - - - - - - - - - - - PHB_acc,PHB_acc_N k59_668632_1 679935.Alfi_1590 5.74e-48 173.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia,22UQM@171550|Rikenellaceae 976|Bacteroidetes G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_668632_2 997884.HMPREF1068_01670 6.54e-07 51.2 COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,2FMAW@200643|Bacteroidia,4AK8N@815|Bacteroidaceae 976|Bacteroidetes P COG COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - DUF4976,Sulfatase k59_44773_1 706587.Desti_1859 1.47e-18 83.6 COG3842@1|root,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,42MSG@68525|delta/epsilon subdivisions,2WPUK@28221|Deltaproteobacteria 28221|Deltaproteobacteria E pfam abc - - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran k59_44773_3 572480.Arnit_0043 1.02e-25 101.0 COG3585@1|root,COG3585@2|Bacteria,1N06J@1224|Proteobacteria,42U4N@68525|delta/epsilon subdivisions,2YQ5D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H TOBE domain - - - - - - - - - - - - TOBE k59_44773_4 572480.Arnit_0044 1.17e-95 286.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42QWE@68525|delta/epsilon subdivisions,2YNG3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_505653_2 1249627.D779_0388 1.1e-79 239.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,1WXGS@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, small subunit - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_929862_1 331869.BAL199_30047 2.39e-67 221.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,4BP55@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type dipeptide transport system, periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_602973_1 1249480.B649_07270 8e-24 98.6 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2YNAC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_602973_2 553220.CAMGR0001_1460 2.28e-10 61.6 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,42PAW@68525|delta/epsilon subdivisions,2YNM3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_1026521_2 1220534.B655_1679 3.14e-27 112.0 COG2074@1|root,arCOG01967@2157|Archaea,2XVZC@28890|Euryarchaeota,23NM4@183925|Methanobacteria 183925|Methanobacteria F ATP cone domain pgk2 - - ko:K05715 - - R02664 RC00002,RC00017 ko00000,ko01000 - - - ATP-cone k59_145895_1 247490.KSU1_C1128 1.26e-19 90.9 COG3437@1|root,COG3437@2|Bacteria,2J518@203682|Planctomycetes 203682|Planctomycetes T HD domain - - - - - - - - - - - - GAF_2,HD,HD_5 k59_765430_1 582402.Hbal_2907 6.4e-23 99.4 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria,43WBE@69657|Hyphomonadaceae 28211|Alphaproteobacteria E COG1115 Na alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_765430_2 583355.Caka_2913 8.86e-76 232.0 COG3005@1|root,COG3005@2|Bacteria,46T0N@74201|Verrucomicrobia,3K8D9@414999|Opitutae 414999|Opitutae C TIGRFAM cytochrome c nitrate reductase, small subunit - - - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT k59_765430_3 338963.Pcar_2866 3.02e-127 376.0 COG3303@1|root,COG3303@2|Bacteria,1MVJT@1224|Proteobacteria,42MPU@68525|delta/epsilon subdivisions,2WIJ1@28221|Deltaproteobacteria,43UNQ@69541|Desulfuromonadales 28221|Deltaproteobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process nrfA - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 k59_795056_1 500632.CLONEX_02834 1.77e-269 744.0 COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia 186801|Clostridia C biosynthesis protein ThiH hydG - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM k59_795056_2 397288.C806_00137 1e-31 112.0 COG0864@1|root,COG0864@2|Bacteria,1VF9M@1239|Firmicutes,24QVJ@186801|Clostridia,27PEA@186928|unclassified Lachnospiraceae 186801|Clostridia K Iron-only hydrogenase system regulator - - - - - - - - - - - - - k59_795056_4 304371.MCP_2259 4.18e-119 358.0 COG0477@1|root,arCOG00130@2157|Archaea,2XWXX@28890|Euryarchaeota,2N9J6@224756|Methanomicrobia 224756|Methanomicrobia G TIGRFAM drug resistance transporter, Bcr CflA subfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_795056_5 572544.Ilyop_1761 5.11e-30 114.0 COG2013@1|root,COG2013@2|Bacteria,37B66@32066|Fusobacteria 32066|Fusobacteria S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k59_342113_1 1249480.B649_05760 1.45e-07 52.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YM96@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cmeF - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_342113_2 1122612.AUBA01000006_gene2397 8.47e-06 52.4 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2U3S4@28211|Alphaproteobacteria,2KCZG@204457|Sphingomonadales 204457|Sphingomonadales V HlyD membrane-fusion protein of T1SS - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_961759_1 709032.Sulku_0749 1.95e-97 291.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2YN5P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_961759_2 563040.Saut_0767 1.23e-49 166.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2YMQZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_830992_1 1125973.JNLC01000001_gene46 8.07e-164 500.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,3JUU3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E B12 binding domain metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_765449_1 261292.Nit79A3_3002 6.15e-20 93.2 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales 28216|Betaproteobacteria I acyl-CoA dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_242450_2 760154.Sulba_1632 4.21e-129 383.0 COG0477@1|root,COG2814@2|Bacteria,1MVSC@1224|Proteobacteria,42P6B@68525|delta/epsilon subdivisions,2YNAT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_242450_3 572480.Arnit_0538 9.4e-222 619.0 COG0477@1|root,COG2814@2|Bacteria,1PSYA@1224|Proteobacteria,42P2S@68525|delta/epsilon subdivisions,2YPFJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_242450_4 572480.Arnit_0537 1.91e-314 869.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42MRT@68525|delta/epsilon subdivisions,2YNPE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_242450_5 572480.Arnit_0536 5.82e-314 868.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42N62@68525|delta/epsilon subdivisions,2YMSJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Abc transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_242450_6 760154.Sulba_1636 0.0 960.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,42MNM@68525|delta/epsilon subdivisions,2YPZ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB-dependent receptor - - - ko:K02014,ko:K15721 - - - - ko00000,ko02000 1.B.14,1.B.14.7.2 - - Plug,TonB_dep_Rec k59_242450_7 1499689.CCNN01000007_gene2326 1.04e-21 101.0 COG2207@1|root,COG2207@2|Bacteria,1TS8C@1239|Firmicutes,25AZI@186801|Clostridia,36W6W@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_635542_1 765911.Thivi_3794 7.54e-138 407.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_569870_1 765913.ThidrDRAFT_0340 5.8e-113 333.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,1WXIR@135613|Chromatiales 135613|Chromatiales S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation - - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_668665_1 938709.AUSH02000017_gene1070 3.44e-36 140.0 COG0308@1|root,COG0308@2|Bacteria,4NG5Q@976|Bacteroidetes 976|Bacteroidetes E peptidase M1 pepN1 - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M1 k59_210796_1 439235.Dalk_2282 1.55e-47 169.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WKC0@28221|Deltaproteobacteria,2MI11@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K10819 - - - - ko00000,ko01000 - - - HATPase_c,HisKA,PAS_8,PAS_9,sCache_3_2 k59_569873_1 1347086.CCBA010000023_gene2347 4.93e-144 427.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli,1ZPV2@1386|Bacillus 91061|Bacilli G Belongs to the glycosyl hydrolase 3 family bglB - 3.2.1.21,3.2.1.52 ko:K01207,ko:K05349 ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501 M00628 R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko00002,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 k59_405840_1 13349.G1X227 3.03e-11 69.3 COG0465@1|root,KOG0743@2759|Eukaryota,38CMD@33154|Opisthokonta,3NVKH@4751|Fungi,3QKI7@4890|Ascomycota 4751|Fungi O Belongs to the AAA ATPase family BCS1 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006810,GO:0006996,GO:0007005,GO:0007006,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017004,GO:0017062,GO:0017111,GO:0019866,GO:0022607,GO:0022857,GO:0022884,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032978,GO:0032979,GO:0033036,GO:0033108,GO:0033365,GO:0034551,GO:0034613,GO:0034622,GO:0042623,GO:0042886,GO:0042887,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0051131,GO:0051179,GO:0051204,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065003,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072655,GO:0072657,GO:0090150,GO:1904680 - ko:K08900 - - - - ko00000,ko03029 - - - AAA,BCS1_N k59_635550_1 387093.SUN_1672 1.81e-113 342.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_635554_1 1121861.KB899940_gene3722 1.53e-96 288.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,2JV2N@204441|Rhodospirillales 204441|Rhodospirillales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_731977_1 572544.Ilyop_0226 3e-56 186.0 COG0006@1|root,COG0006@2|Bacteria,379I8@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_731977_2 1123326.JFBL01000001_gene1477 6.06e-93 290.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,42P0P@68525|delta/epsilon subdivisions,2YN3S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Na H antiporter nhaC - - - - - - - - - - - Na_H_antiporter k59_438019_1 709032.Sulku_0715 2.97e-215 603.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2YMT3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretion system ctsF - - ko:K02455,ko:K12278 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_438019_2 929558.SMGD1_2291 3.5e-16 77.8 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_273880_1 1168034.FH5T_16320 4.61e-84 256.0 COG1702@1|root,COG1702@2|Bacteria,4NDYV@976|Bacteroidetes,2FMIF@200643|Bacteroidia 976|Bacteroidetes T PhoH family phoH - - ko:K06217 - - - - ko00000 - - - PhoH k59_1026579_1 1165841.SULAR_07955 5.04e-80 240.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,42NSE@68525|delta/epsilon subdivisions,2YMUG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_1026579_2 1165841.SULAR_07950 6.46e-10 56.2 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2YPXD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_145942_1 1116369.KB890024_gene1900 2.14e-08 61.6 COG2199@1|root,COG3706@2|Bacteria,1R9Z4@1224|Proteobacteria,2VF8Z@28211|Alphaproteobacteria,43KBG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_603040_1 1033743.CAES01000104_gene3413 1.29e-17 87.0 COG1680@1|root,COG1680@2|Bacteria,1TRR5@1239|Firmicutes,4HAZF@91061|Bacilli,26TNG@186822|Paenibacillaceae 91061|Bacilli V penicillin-binding protein pbpX - - - - - - - - - - - Beta-lactamase k59_44832_1 272630.MexAM1_META1p4097 1.2e-26 102.0 COG3450@1|root,COG3450@2|Bacteria,1N0F7@1224|Proteobacteria,2VGV5@28211|Alphaproteobacteria,1JV32@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF861) - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_44832_2 587753.EY04_14810 2.57e-24 103.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria 1224|Proteobacteria E Belongs to the PHP family dpx - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_961797_1 1265505.ATUG01000002_gene2098 4.81e-132 380.0 COG1175@1|root,COG1175@2|Bacteria,1MVAZ@1224|Proteobacteria,42PPH@68525|delta/epsilon subdivisions,2WKZS@28221|Deltaproteobacteria,2MMPW@213118|Desulfobacterales 28221|Deltaproteobacteria G Binding-protein-dependent transport system inner membrane component - - - ko:K17322 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - BPD_transp_1 k59_145946_1 1121101.HMPREF1532_01927 3.51e-62 214.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia,4AK8A@815|Bacteroidaceae 976|Bacteroidetes G glycosyl hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_8902_1 246200.SPO2197 2.28e-60 196.0 COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2TU43@28211|Alphaproteobacteria,4NA6W@97050|Ruegeria 28211|Alphaproteobacteria S Tetracycline resistance protein yedI - - ko:K09781 - - - - ko00000 - - - DUF808 k59_210845_2 1260251.SPISAL_01255 3.06e-19 83.2 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_569912_1 1236514.BAKL01000005_gene627 1.07e-10 60.8 COG5520@1|root,COG5520@2|Bacteria,4NF4C@976|Bacteroidetes,2FNPT@200643|Bacteroidia,4AM5V@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 30 family - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - Glyco_hydro_30,Glyco_hydro_30C k59_569912_2 1168034.FH5T_13395 8.14e-08 55.8 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,2FPM1@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_863215_1 572544.Ilyop_0536 1.12e-102 311.0 COG4656@1|root,COG4656@2|Bacteria,3791P@32066|Fusobacteria 32066|Fusobacteria C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,RnfC_N,SLBB k59_831061_1 404589.Anae109_3714 7.87e-42 139.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2YVK0@29|Myxococcales 28221|Deltaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_831061_2 29730.Gorai.006G219200.1 8.73e-06 47.4 COG0459@1|root,KOG0356@2759|Eukaryota,37HQ6@33090|Viridiplantae,3GE25@35493|Streptophyta 35493|Streptophyta O Belongs to the chaperonin (HSP60) family - GO:0000166,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005507,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005773,GO:0005774,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006457,GO:0006458,GO:0006605,GO:0006626,GO:0006810,GO:0006839,GO:0006886,GO:0006950,GO:0006996,GO:0007005,GO:0008104,GO:0008144,GO:0008150,GO:0009266,GO:0009408,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009628,GO:0009719,GO:0009725,GO:0009735,GO:0009941,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0017038,GO:0017076,GO:0022626,GO:0030554,GO:0031090,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042221,GO:0042788,GO:0042886,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044183,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044743,GO:0045041,GO:0045184,GO:0046686,GO:0046872,GO:0046907,GO:0046914,GO:0050896,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070013,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072655,GO:0097159,GO:0097367,GO:0098588,GO:0098805,GO:1901265,GO:1901363,GO:1990542,GO:1990904 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_405895_1 338963.Pcar_2072 6.83e-76 248.0 COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,42NJ1@68525|delta/epsilon subdivisions,2WJ5S@28221|Deltaproteobacteria,43U9J@69541|Desulfuromonadales 28221|Deltaproteobacteria J THUMP rlmL - 2.1.1.173,2.1.1.264 ko:K07444,ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_112136_1 1168034.FH5T_13820 8.89e-36 126.0 COG0036@1|root,COG0036@2|Bacteria,4NDXB@976|Bacteroidetes,2FM7Z@200643|Bacteroidia 976|Bacteroidetes G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_112136_2 1168034.FH5T_13815 3.39e-177 497.0 COG0568@1|root,COG0568@2|Bacteria,4NEBF@976|Bacteroidetes,2FWAQ@200643|Bacteroidia 976|Bacteroidetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_112136_3 1168034.FH5T_13810 8.69e-115 342.0 COG0498@1|root,COG0498@2|Bacteria,4NEAA@976|Bacteroidetes,2FMPH@200643|Bacteroidia 976|Bacteroidetes E Threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_synth_N k59_766013_3 1249480.B649_06795 3.07e-80 244.0 2BV3K@1|root,3187I@2|Bacteria,1PZXK@1224|Proteobacteria,430TM@68525|delta/epsilon subdivisions,2YS1S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_831474_1 1223410.KN050846_gene1012 1.15e-85 273.0 COG0317@1|root,COG0317@2|Bacteria,4NESY@976|Bacteroidetes,1HX98@117743|Flavobacteriia 976|Bacteroidetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_471481_1 158189.SpiBuddy_0825 1.45e-60 210.0 COG1033@1|root,COG1033@2|Bacteria,2J5SQ@203691|Spirochaetes 203691|Spirochaetes S COGs COG1033 exporter of the RND superfamily protein - - - ko:K07003 - - - - ko00000 - - - MMPL k59_438475_1 760154.Sulba_1520 1.5e-54 183.0 COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42N49@68525|delta/epsilon subdivisions,2YND2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA k59_896859_1 565045.NOR51B_1955 2.82e-12 68.2 COG2067@1|root,COG2067@2|Bacteria,1NDQA@1224|Proteobacteria,1TIWZ@1236|Gammaproteobacteria,1JBA2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - - k59_506236_1 335543.Sfum_0020 3.91e-90 288.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_178934_1 1156937.MFUM_370008 1e-38 144.0 COG0438@1|root,COG4122@1|root,COG0438@2|Bacteria,COG4122@2|Bacteria,46W9Y@74201|Verrucomicrobia 74201|Verrucomicrobia M Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_570288_1 1150626.PHAMO_370015 3.47e-07 50.8 COG2963@1|root,COG2963@2|Bacteria,1N0AJ@1224|Proteobacteria,2UDRV@28211|Alphaproteobacteria,2JX77@204441|Rhodospirillales 204441|Rhodospirillales L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_570288_2 1150626.PHAMO_370014 1.26e-80 252.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,2JZN8@204441|Rhodospirillales 204441|Rhodospirillales L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_995537_1 1267534.KB906755_gene4805 1.69e-09 63.2 28MAS@1|root,2ZAPE@2|Bacteria,3Y6VW@57723|Acidobacteria 57723|Acidobacteria S Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 k59_995537_2 596154.Alide2_1041 1e-12 70.1 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,4AGYA@80864|Comamonadaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_538385_1 1537917.JU82_11375 7.41e-68 216.0 COG2897@1|root,COG2897@2|Bacteria,1P6SN@1224|Proteobacteria,42VHJ@68525|delta/epsilon subdivisions,2YQHF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_930381_1 863365.XHC_2206 3.08e-19 93.2 COG2199@1|root,COG3706@2|Bacteria,1MXBG@1224|Proteobacteria,1RNJA@1236|Gammaproteobacteria,1X4QB@135614|Xanthomonadales 135614|Xanthomonadales T Diguanylate cyclase rrpX - - - - - - - - - - - GGDEF,Response_reg k59_962289_1 1168034.FH5T_18735 1.66e-39 137.0 COG0682@1|root,COG0682@2|Bacteria,4NFP7@976|Bacteroidetes,2FMXU@200643|Bacteroidia 976|Bacteroidetes M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - - - - - - - - - - LGT k59_962289_2 1168034.FH5T_18730 2.25e-60 207.0 COG0653@1|root,COG0653@2|Bacteria,4NF7C@976|Bacteroidetes,2FMVF@200643|Bacteroidia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_603557_1 749222.Nitsa_0379 4.69e-128 371.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2YNCB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0330 IlvC,IlvN k59_636061_1 926550.CLDAP_06680 1.72e-07 55.8 COG2335@1|root,COG2335@2|Bacteria,2G7AJ@200795|Chloroflexi 200795|Chloroflexi M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin k59_636061_2 317013.NY99_13655 1.35e-100 303.0 COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,1RNUR@1236|Gammaproteobacteria,1X4A2@135614|Xanthomonadales 135614|Xanthomonadales E asparaginase - - 3.4.19.5 ko:K13051 - - - - ko00000,ko01000,ko01002 - - - Asparaginase_2,Peptidase_S51 k59_342674_1 387093.SUN_2234 8.45e-66 224.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,43BP0@68525|delta/epsilon subdivisions,2YTEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LV TaqI-like C-terminal specificity domain - - - - - - - - - - - - N6_Mtase,TaqI_C k59_274309_1 298654.FraEuI1c_4385 9.43e-34 134.0 28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria,4EUNW@85013|Frankiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_732446_1 1384056.N787_06965 1.34e-07 55.8 COG5488@1|root,COG5488@2|Bacteria,1RGEC@1224|Proteobacteria,1T7Q3@1236|Gammaproteobacteria,1X7QB@135614|Xanthomonadales 135614|Xanthomonadales S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_732446_2 1122134.KB893650_gene130 9.05e-31 120.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XIU7@135619|Oceanospirillales 135619|Oceanospirillales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_538394_1 1123368.AUIS01000013_gene856 4.55e-82 268.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,2NBVY@225057|Acidithiobacillales 225057|Acidithiobacillales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - BCA_ABC_TP_C k59_896884_1 471870.BACINT_00976 3.08e-11 69.3 COG3408@1|root,COG3408@2|Bacteria,4NESP@976|Bacteroidetes,2FMGH@200643|Bacteroidia,4AKSK@815|Bacteroidaceae 976|Bacteroidetes G Alpha-L-rhamnosidase N-terminal domain protein - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_700853_1 321846.PS417_01955 2.06e-59 206.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein 1A mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_669225_1 228410.NE2548 1.77e-17 86.7 COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,371W8@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA k59_146349_1 1165841.SULAR_03178 7e-98 290.0 COG3786@1|root,COG3786@2|Bacteria,1RH22@1224|Proteobacteria,42U32@68525|delta/epsilon subdivisions,2YPTI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG3786 conserved - - - - - - - - - - - - YkuD k59_1027078_1 466088.CL42_13125 1.82e-12 69.7 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1SWVA@1236|Gammaproteobacteria,3NIVY@468|Moraxellaceae 1236|Gammaproteobacteria S Uncharacterized ACR, COG1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_1027078_2 95619.PM1_0225705 4.09e-23 89.4 COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_506265_1 192952.MM_1983 6.33e-29 119.0 COG3291@1|root,arCOG02527@1|root,arCOG02538@1|root,arCOG02508@2157|Archaea,arCOG02527@2157|Archaea,arCOG02538@2157|Archaea 2157|Archaea G PFAM PKD domain containing protein - - - - - - - - - - - - Beta_helix,CARDB,Malectin,PKD,PQQ_3,Peptidase_S8 k59_211379_1 1168034.FH5T_16785 2e-88 266.0 COG2133@1|root,COG2133@2|Bacteria,4NGMS@976|Bacteroidetes,2FQQN@200643|Bacteroidia 976|Bacteroidetes G Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 k59_506274_2 933262.AXAM01000083_gene762 8.33e-102 306.0 COG0426@1|root,COG0426@2|Bacteria,1R4UD@1224|Proteobacteria,43AF5@68525|delta/epsilon subdivisions,2X5UW@28221|Deltaproteobacteria,2MPG5@213118|Desulfobacterales 28221|Deltaproteobacteria C Flavodoxin roo - - - - - - - - - - - Flavodoxin_1,Lactamase_B,Lactamase_B_2 k59_242986_1 933262.AXAM01000078_gene1610 2.02e-27 107.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,42NHN@68525|delta/epsilon subdivisions,2WJ4S@28221|Deltaproteobacteria,2MHWJ@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM cytochrome d ubiquinol oxidase, subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_242986_2 177437.HRM2_40720 8.83e-44 155.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2MID8@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM cytochrome bd ubiquinol oxidase subunit I cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_962313_1 933262.AXAM01000009_gene1470 1.21e-62 211.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,42M2D@68525|delta/epsilon subdivisions,2WJU6@28221|Deltaproteobacteria,2MIPQ@213118|Desulfobacterales 28221|Deltaproteobacteria M Lipopolysaccharide biosynthesis protein wzc1 - - - - - - - - - - - GNVR,Wzz k59_9226_1 1232437.KL661988_gene233 1.34e-40 142.0 COG0489@1|root,COG0489@2|Bacteria,1R6AC@1224|Proteobacteria,42NTJ@68525|delta/epsilon subdivisions,2WM95@28221|Deltaproteobacteria,2MJ5Z@213118|Desulfobacterales 28221|Deltaproteobacteria D protein tyrosine kinase activity - - - - - - - - - - - - - k59_9226_2 1307759.JOMJ01000003_gene575 7.75e-05 44.7 COG1146@1|root,COG1146@2|Bacteria,1NJJD@1224|Proteobacteria,42VKY@68525|delta/epsilon subdivisions,2WRXE@28221|Deltaproteobacteria,2MD3G@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7 k59_9226_3 1121405.dsmv_1449 1.36e-22 94.4 COG0674@1|root,COG0674@2|Bacteria,1MWCI@1224|Proteobacteria,42NJY@68525|delta/epsilon subdivisions,2WIW3@28221|Deltaproteobacteria,2MHPN@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II vorA - 1.2.7.11,1.2.7.3,1.2.7.7 ko:K00174,ko:K00186 ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197,R07160,R08566,R08567 RC00004,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1307 PFOR_II,POR_N k59_146370_1 1177928.TH2_00060 9.52e-88 268.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2TR1C@28211|Alphaproteobacteria,2JQB9@204441|Rhodospirillales 204441|Rhodospirillales P COG0226 ABC-type phosphate transport system, periplasmic component pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_146370_2 1279038.KB907338_gene864 4.71e-16 77.8 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,2JQK1@204441|Rhodospirillales 204441|Rhodospirillales P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_1027102_1 757424.Hsero_0185 9.54e-10 62.4 COG3203@1|root,COG3203@2|Bacteria,1R9DF@1224|Proteobacteria,2VH5X@28216|Betaproteobacteria,4763Q@75682|Oxalobacteraceae 28216|Betaproteobacteria M Outer membrane protein (Porin) - - - - - - - - - - - - Porin_4 k59_211384_1 387093.SUN_0491 1.23e-94 288.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ7@1224|Proteobacteria,43BJF@68525|delta/epsilon subdivisions,2YNM7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,sCache_like k59_9232_1 1168034.FH5T_09460 1.04e-158 451.0 COG0216@1|root,COG0216@2|Bacteria,4NF72@976|Bacteroidetes,2FNKW@200643|Bacteroidia 976|Bacteroidetes J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1027103_1 1238450.VIBNISOn1_410022 0.000678 42.0 COG1172@1|root,COG1172@2|Bacteria,1MV4F@1224|Proteobacteria,1SZDU@1236|Gammaproteobacteria,1Y0F3@135623|Vibrionales 135623|Vibrionales G Branched-chain amino acid transport system / permease component - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 k59_1027103_2 530564.Psta_2540 4.73e-37 144.0 COG1172@1|root,COG1172@2|Bacteria,2IZWQ@203682|Planctomycetes 203682|Planctomycetes G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10440,ko:K10559,ko:K10561 ko02010,map02010 M00212,M00220 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9 - - BPD_transp_2 k59_374128_1 1168034.FH5T_10045 2.23e-119 350.0 COG0263@1|root,COG0263@2|Bacteria,4NH75@976|Bacteroidetes,2FM31@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_406388_1 1168034.FH5T_17535 3.18e-189 532.0 COG0156@1|root,COG0156@2|Bacteria,4NFRY@976|Bacteroidetes,2FNXA@200643|Bacteroidia 976|Bacteroidetes E Aminotransferase class I and II - - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_636085_1 1168034.FH5T_09765 6.18e-22 86.7 COG3197@1|root,COG3197@2|Bacteria,4NUR7@976|Bacteroidetes 976|Bacteroidetes P Cytochrome oxidase maturation protein ccoS - - - - - - - - - - - FixS k59_636085_2 1168034.FH5T_09760 6.04e-104 323.0 COG2010@1|root,COG2993@1|root,COG3278@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO k59_863711_1 1229487.AMYW01000002_gene1530 2.26e-62 204.0 COG1216@1|root,COG1216@2|Bacteria,4NFEP@976|Bacteroidetes,1HWUH@117743|Flavobacteriia,2NV58@237|Flavobacterium 976|Bacteroidetes S Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 k59_896909_1 765912.Thimo_0188 5.76e-59 192.0 COG1043@1|root,COG1043@2|Bacteria,1QKYH@1224|Proteobacteria,1S0N9@1236|Gammaproteobacteria,1WXE9@135613|Chromatiales 135613|Chromatiales I Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_374135_1 311403.Arad_0178 5.72e-56 190.0 COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRD2@28211|Alphaproteobacteria,4B7WB@82115|Rhizobiaceae 28211|Alphaproteobacteria M Lytic murein transglycosylase MA20_01345 - - - - - - - - - - - PG_binding_1,SLT_2 k59_831542_1 675814.VIC_002392 3.74e-28 119.0 COG2373@1|root,COG2373@2|Bacteria,1R126@1224|Proteobacteria,1T4TY@1236|Gammaproteobacteria,1XVWF@135623|Vibrionales 135623|Vibrionales S Large extracellular alpha-helical protein - - - - - - - - - - - - - k59_732497_1 1026882.MAMP_01350 3.99e-110 345.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,4606D@72273|Thiotrichales 72273|Thiotrichales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_178968_1 1323663.AROI01000027_gene1589 1.71e-27 109.0 COG3943@1|root,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,1RPNB@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3943 Virulence protein - - - - - - - - - - - - Virulence_RhuM k59_178968_2 1123277.KB893227_gene417 9.54e-21 85.5 COG2026@1|root,COG2026@2|Bacteria 2|Bacteria DJ nuclease activity - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin k59_1027112_1 349521.HCH_04416 8.89e-146 427.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,1XICD@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome D1 heme domain - - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_45299_2 1442598.JABW01000012_gene368 7.01e-24 94.4 COG2026@1|root,COG2026@2|Bacteria 2|Bacteria DJ nuclease activity - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin k59_374138_1 765910.MARPU_11150 5.27e-79 245.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1WWVD@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_766067_1 1279015.KB908454_gene741 1.22e-06 50.8 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1Y4ZT@135624|Aeromonadales 135624|Aeromonadales M Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - POTRA,Patatin k59_766067_2 1538295.JY96_15285 1.16e-14 78.2 COG0729@1|root,COG1752@1|root,COG0729@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,1KJVX@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_732502_1 530564.Psta_1401 1.49e-40 146.0 COG2017@1|root,COG2017@2|Bacteria,2IWRW@203682|Planctomycetes 203682|Planctomycetes G Converts alpha-aldose to the beta-anomer - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_995605_1 572544.Ilyop_0614 1.71e-48 169.0 COG1164@1|root,COG1164@2|Bacteria,3797Y@32066|Fusobacteria 32066|Fusobacteria E oligoendopeptidase, M3 family - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_995605_2 572544.Ilyop_0615 3.39e-29 110.0 COG0597@1|root,COG0597@2|Bacteria 2|Bacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_995605_3 399741.Spro_4315 1.25e-60 192.0 COG1451@1|root,COG1451@2|Bacteria,1RDJ9@1224|Proteobacteria,1S45M@1236|Gammaproteobacteria,40255@613|Serratia 1236|Gammaproteobacteria S Metal-dependent hydrolase ygjP - - ko:K07043 - - - - ko00000 - - - DUF45 k59_45314_1 999141.GME_10236 7.35e-11 61.2 COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,1RPKU@1236|Gammaproteobacteria,1XJ3U@135619|Oceanospirillales 135619|Oceanospirillales G Belongs to the MIP aquaporin (TC 1.A.8) family aqpZ - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP k59_766071_1 563040.Saut_1439 2.88e-60 194.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2YMT4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_766071_2 1244531.CIG1485E_0575 0.000467 42.0 COG0526@1|root,COG0526@2|Bacteria,1RKKW@1224|Proteobacteria,42SHJ@68525|delta/epsilon subdivisions,2YPQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thioredoxin-like resA - - - - - - - - - - - AhpC-TSA,Redoxin,Thioredoxin,Thioredoxin_8 k59_669290_1 98439.AJLL01000106_gene3500 6.99e-63 206.0 COG3842@1|root,COG3842@2|Bacteria,1G1HQ@1117|Cyanobacteria,1JIEK@1189|Stigonemataceae 1117|Cyanobacteria E TOBE domain potA - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 k59_669295_1 232346.JHQL01000001_gene2222 1.72e-10 60.5 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1XHKP@135619|Oceanospirillales 135619|Oceanospirillales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_897521_1 573569.F7308_0300 6.55e-293 808.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,460QY@72273|Thiotrichales 72273|Thiotrichales V HsdM N-terminal domain - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_897521_2 585.DR95_3009 5.85e-122 365.0 COG0732@1|root,COG0732@2|Bacteria,1MXSQ@1224|Proteobacteria,1S320@1236|Gammaproteobacteria 1236|Gammaproteobacteria V restriction modification system DNA specificity hsdS - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_897521_3 767817.Desgi_1005 9.94e-81 247.0 2ENKD@1|root,33G7T@2|Bacteria 2|Bacteria S Abortive infection C-terminus - - - - - - - - - - - - Abi_C k59_897521_4 946483.Cenrod_2431 1e-05 46.6 COG0732@1|root,COG0732@2|Bacteria,1PFCE@1224|Proteobacteria,2W3VR@28216|Betaproteobacteria,4AIRI@80864|Comamonadaceae 28216|Betaproteobacteria L Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - - k59_897521_5 1121342.AUCO01000010_gene2251 1.78e-12 70.5 28PCC@1|root,2ZC4Q@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_113223_2 1122165.AUHS01000014_gene2770 7.36e-23 93.2 COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,1S6XJ@1236|Gammaproteobacteria,1JEA1@118969|Legionellales 118969|Legionellales S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_931015_1 504472.Slin_3483 4.48e-60 199.0 COG1252@1|root,COG1252@2|Bacteria,4NE0H@976|Bacteroidetes,47K1Q@768503|Cytophagia 976|Bacteroidetes C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_796059_1 572544.Ilyop_1015 3.2e-79 249.0 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - - - - - - - - - - HNH_4 k59_308488_1 439235.Dalk_1747 1.17e-52 189.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2972@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG2972@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MHXT@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CHASE8,GAF_2,HAMP,HATPase_c,HisKA,Hpt,MASE2,PAS_4,PAS_9,Response_reg k59_308493_1 1168034.FH5T_01705 5.2e-129 375.0 COG0628@1|root,COG0628@2|Bacteria,4NFHZ@976|Bacteroidetes,2FN2B@200643|Bacteroidia 2|Bacteria F Psort location CytoplasmicMembrane, score 10.00 tqsA - - - - - - - - - - - AI-2E_transport k59_439205_1 388413.ALPR1_21088 3.8e-36 142.0 COG1361@1|root,COG3210@1|root,COG5184@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - CHU_C,DUF11 k59_604263_1 768671.ThimaDRAFT_3835 1.76e-59 191.0 COG0369@1|root,COG0369@2|Bacteria,1NCKQ@1224|Proteobacteria,1RR4U@1236|Gammaproteobacteria,1WX7N@135613|Chromatiales 135613|Chromatiales P PFAM Oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.8.1.2 ko:K00380,ko:K02641 ko00195,ko00920,ko01100,ko01120,map00195,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko00194,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_374730_1 1249480.B649_01190 9.73e-05 43.5 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42RES@68525|delta/epsilon subdivisions,2YP9Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_374730_2 709032.Sulku_0273 1.91e-108 316.0 COG1143@1|root,COG1143@2|Bacteria,1MZJF@1224|Proteobacteria,42M7S@68525|delta/epsilon subdivisions,2YNEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_374730_3 387093.SUN_2224 6.64e-10 58.5 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2YMNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_733107_1 1131553.JIBI01000051_gene968 8.98e-101 298.0 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,2VM5K@28216|Betaproteobacteria,3744J@32003|Nitrosomonadales 28216|Betaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_179651_1 33035.JPJF01000027_gene2737 7.55e-58 196.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XZDA@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_832161_1 1001585.MDS_4812 7.39e-53 173.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1YFG1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Bacterial transferase hexapeptide (six repeats) yrdA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840 - - - - - - - - - - Hexapep k59_243664_1 1158292.JPOE01000002_gene2840 7.15e-79 256.0 COG2211@1|root,COG5309@1|root,COG2211@2|Bacteria,COG5309@2|Bacteria,1MWJJ@1224|Proteobacteria,2VIIU@28216|Betaproteobacteria 28216|Betaproteobacteria G beta (1-6) glucans synthase - - 3.2.1.58 ko:K01210 ko00500,map00500 - R00308,R03115 RC00467 ko00000,ko00001,ko01000 - - - Glyco_hydro_17 k59_962962_1 572544.Ilyop_1377 2e-100 304.0 COG1519@1|root,COG1519@2|Bacteria,378F3@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527,ko:K03439 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03016 - GT30 - Glycos_transf_N,Methyltransf_4 k59_636742_1 1501230.ET33_22710 1.09e-25 110.0 COG2227@1|root,COG3321@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins - - - ko:K13612 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_212060_1 313603.FB2170_14823 1.49e-09 64.3 2919D@1|root,2ZNWG@2|Bacteria,4NMU5@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_472217_1 172088.AUGA01000007_gene8426 0.000246 42.7 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TU35@28211|Alphaproteobacteria,3JXWE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Di-haem cytochrome c peroxidase mauG GO:0005575,GO:0005623,GO:0042597,GO:0044464 - - - - - - - - - - CCP_MauG,Cytochrom_C k59_472217_2 1397528.Q671_12215 7.1e-67 216.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1XIU2@135619|Oceanospirillales 135619|Oceanospirillales P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_9959_1 1122135.KB893137_gene1217 7.99e-55 185.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2U4XB@28211|Alphaproteobacteria 28211|Alphaproteobacteria P MgtE intracellular N domain - - - - - - - - - - - - CBS,MgtE,MgtE_N k59_9959_2 237727.NAP1_10348 9.6e-20 87.0 COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2TUMH@28211|Alphaproteobacteria,2K1HN@204457|Sphingomonadales 204457|Sphingomonadales G Aldolase - - - - - - - - - - - - Aldolase k59_604284_1 1288826.MSNKSG1_17466 5.3e-83 258.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,465FN@72275|Alteromonadaceae 1236|Gammaproteobacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_1027827_1 1165841.SULAR_00945 3.17e-115 344.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2YMQ6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_539198_1 1537917.JU82_05810 6.73e-122 364.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2YN92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_179666_1 997296.PB1_15144 3.67e-31 132.0 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,4HAG2@91061|Bacilli,1ZC16@1386|Bacillus 91061|Bacilli L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_113261_2 1163407.UU7_07821 1.76e-15 71.2 COG1652@1|root,COG1652@2|Bacteria,1RD8K@1224|Proteobacteria,1S4CB@1236|Gammaproteobacteria,1XCRN@135614|Xanthomonadales 135614|Xanthomonadales S Lysin motif - - - - - - - - - - - - LysM k59_479345_2 537013.CLOSTMETH_00226 2.07e-05 46.2 COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,25KIW@186801|Clostridia,3WMDA@541000|Ruminococcaceae 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_413975_2 595537.Varpa_0266 1.29e-81 260.0 COG0644@1|root,COG0644@2|Bacteria,1MZ3Z@1224|Proteobacteria,2VIEH@28216|Betaproteobacteria,4AHDP@80864|Comamonadaceae 28216|Betaproteobacteria C Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_643786_1 554065.XP_005847280.1 4.53e-06 53.9 COG1231@1|root,KOG0029@2759|Eukaryota,37KUS@33090|Viridiplantae,34JQI@3041|Chlorophyta 3041|Chlorophyta Q Flavin containing amine oxidoreductase - - - ko:K11450 ko04714,map04714 - - - ko00000,ko00001,ko01000,ko03036 - - - Amino_oxidase,DEK_C,SWIRM k59_803174_1 1232410.KI421421_gene3541 1.36e-39 137.0 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,42WGY@68525|delta/epsilon subdivisions,2WS4W@28221|Deltaproteobacteria,43VDK@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_250874_1 663610.JQKO01000001_gene689 2.07e-32 123.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,2TRH2@28211|Alphaproteobacteria,3NANE@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Prolyl 4-hydroxylase alpha subunit homologues. piuC - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_281943_1 933262.AXAM01000016_gene149 2.09e-61 209.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_773943_2 1123400.KB904766_gene2958 1.73e-11 69.3 COG0457@1|root,COG0457@2|Bacteria,1N3T7@1224|Proteobacteria,1T1KY@1236|Gammaproteobacteria,46360@72273|Thiotrichales 72273|Thiotrichales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 k59_803177_1 1379281.AVAG01000023_gene1900 7.01e-61 205.0 COG0745@1|root,COG1413@1|root,COG0745@2|Bacteria,COG1413@2|Bacteria,1R5AP@1224|Proteobacteria,42P8K@68525|delta/epsilon subdivisions,2WKU6@28221|Deltaproteobacteria,2M9XY@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - HEAT_2,Response_reg k59_52882_1 439235.Dalk_5173 7.62e-55 192.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria,2MIG9@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_937951_1 709986.Deima_0267 2.7e-08 59.7 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_578182_1 929558.SMGD1_1568 1.58e-91 281.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2YMDS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_381819_1 1121351.AUAP01000002_gene442 4.66e-17 82.8 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KPH3@206351|Neisseriales 206351|Neisseriales P Psort location CytoplasmicMembrane, score - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_381819_2 1454004.AW11_01642 1.64e-10 61.2 COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria 28216|Betaproteobacteria S FixH - - - ko:K09926 - - - - ko00000 - - - FixH k59_381819_3 713587.THITH_06425 6.24e-44 159.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales 135613|Chromatiales C TIGRFAM cytochrome c oxidase accessory protein - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_611176_1 1137799.GZ78_18485 7.17e-08 59.3 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1XK5H@135619|Oceanospirillales 135619|Oceanospirillales D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri k59_350418_1 240016.ABIZ01000001_gene4065 4.02e-27 104.0 COG0096@1|root,COG0096@2|Bacteria,46T2K@74201|Verrucomicrobia,2IUCT@203494|Verrucomicrobiae 203494|Verrucomicrobiae J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_350418_2 1121927.GOHSU_06_00250 3.31e-06 47.8 COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4GBBW@85026|Gordoniaceae 201174|Actinobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_839310_1 944547.ABLL_2329 7.53e-97 297.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE k59_1003357_1 553218.CAMRE0001_2740 3.71e-38 141.0 2BU4Q@1|root,32PDM@2|Bacteria,1Q472@1224|Proteobacteria,42YGV@68525|delta/epsilon subdivisions,2YR9F@29547|Epsilonproteobacteria 553218.CAMRE0001_2740|- S by glimmer - - - - - - - - - - - - - k59_1003357_2 553218.CAMRE0001_2739 3.8e-85 282.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,432NK@68525|delta/epsilon subdivisions,2YSUP@29547|Epsilonproteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - An_peroxidase,Big_3_2,HemolysinCabind k59_740163_1 572544.Ilyop_0824 1.43e-40 144.0 COG3307@1|root,COG3307@2|Bacteria 2|Bacteria M -O-antigen rfaL - - ko:K02847 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 - - Wzy_C k59_740163_2 1123242.JH636434_gene4269 1.66e-09 67.4 COG0438@1|root,COG0438@2|Bacteria,2IY70@203682|Planctomycetes 203682|Planctomycetes M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_773958_1 1462526.BN990_00831 3.1e-52 179.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,4C594@84406|Virgibacillus 91061|Bacilli G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_773958_2 1209989.TepiRe1_0413 8.04e-23 94.7 COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,42EK7@68295|Thermoanaerobacterales 186801|Clostridia C Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain nfnA - 1.18.1.2,1.19.1.1 ko:K00528,ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146,R10159 RC00065 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_186716_1 929558.SMGD1_0162 1.18e-97 287.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2YNVD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases ycbL - - - - - - - - - - - Lactamase_B k59_514199_1 269800.Tfu_3066 9.32e-05 52.8 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4EFPA@85012|Streptosporangiales 201174|Actinobacteria KLT PASTA pknB GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_937974_1 358681.BBR47_39880 5.1e-64 221.0 COG0236@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksJ - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_740181_2 1123053.AUDG01000040_gene1254 3.24e-47 161.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_52914_1 1123037.AUDE01000012_gene175 6.53e-13 72.8 28J3Q@1|root,2ZBKS@2|Bacteria,4NMY8@976|Bacteroidetes,1I1AM@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (Porph_ging) - - - - - - - - - - - - Porph_ging k59_17264_2 69328.PVLB_11355 4.76e-10 63.9 2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,1S77C@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_611195_1 243090.RB11088 5.32e-25 106.0 COG0457@1|root,COG0457@2|Bacteria,2IYBX@203682|Planctomycetes 203682|Planctomycetes S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_545796_2 640081.Dsui_2320 1.03e-49 172.0 28I8W@1|root,2Z8BP@2|Bacteria,1N0SC@1224|Proteobacteria,2VK0J@28216|Betaproteobacteria,2KVDQ@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF2863) - - - - - - - - - - - - DUF2863 k59_350439_1 472759.Nhal_1612 5.05e-130 408.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1WW7J@135613|Chromatiales 135613|Chromatiales F Ribonucleotide reductase, barrel domain - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_446421_1 1300345.LF41_1710 1.69e-63 203.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,1RZDM@1236|Gammaproteobacteria,1XBXD@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the arginase family - - 3.5.3.1 ko:K01476 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00134 R00551 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_446421_2 292.DM42_4486 3.26e-23 99.0 COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2VHIM@28216|Betaproteobacteria,1K1HC@119060|Burkholderiaceae 28216|Betaproteobacteria E Ornithine cyclodeaminase arcB - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_611201_1 1168034.FH5T_15215 1.05e-129 379.0 COG2195@1|root,COG2195@2|Bacteria,4NE7N@976|Bacteroidetes,2FMBF@200643|Bacteroidia 976|Bacteroidetes E Cleaves the N-terminal amino acid of tripeptides pepT - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_281982_1 1123326.JFBL01000005_gene1065 7.2e-48 164.0 COG0500@1|root,COG0500@2|Bacteria,1QVTR@1224|Proteobacteria,42SC2@68525|delta/epsilon subdivisions,2YPH1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q biotin synthesis protein bioC bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_708773_1 827.JFJK01000005_gene1167 1.54e-21 101.0 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2YN3X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the ompA family cadF - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA k59_350442_1 1121405.dsmv_2974 5.06e-105 332.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2X5GV@28221|Deltaproteobacteria 28221|Deltaproteobacteria EF Carbamoyl-phosphate synthetase large chain, oligomerisation domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_479422_1 391615.ABSJ01000039_gene1826 1.7e-17 87.0 COG1587@1|root,COG2959@1|root,COG1587@2|Bacteria,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1JBT8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H HemX, putative uroporphyrinogen-III C-methyltransferase hemX - 2.1.1.107,4.2.1.75 ko:K02496,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iPC815.YPO3851,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317 HemX k59_120696_2 764561.D7RWF8_9CAUD 5.2e-39 150.0 4QG2D@10239|Viruses,4QY76@35237|dsDNA viruses no RNA stage,4QSXU@28883|Caudovirales,4QM4M@10699|Siphoviridae 10699|Siphoviridae S AAA domain - - - - - - - - - - - - - k59_414048_2 1122605.KB893625_gene2133 1.89e-13 73.2 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1IP9H@117747|Sphingobacteriia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_154128_2 1033802.SSPSH_002388 5.73e-06 45.8 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria 1224|Proteobacteria K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0033739,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.7.1.13 ko:K06879,ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - iSFV_1184.SFV_2663,iSF_1195.SF2807,iS_1188.S3002 QueF,QueF_N k59_937997_1 745718.JADT01000001_gene2036 1.81e-105 316.0 COG0015@1|root,COG0015@2|Bacteria,4NFY8@976|Bacteroidetes,1HXVA@117743|Flavobacteriia 976|Bacteroidetes F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,ASL_C,Lyase_1 k59_1034645_1 536233.CLO_0734 5e-07 50.8 COG2267@1|root,COG2267@2|Bacteria,1UZ5S@1239|Firmicutes,25CEG@186801|Clostridia,36WUK@31979|Clostridiaceae 186801|Clostridia I Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 k59_1034645_2 1041522.MCOL_V223408 1.65e-21 100.0 COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria,232HX@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the GPAT DAPAT family plsB1 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_219238_1 926569.ANT_13490 1.35e-63 207.0 COG0477@1|root,COG2814@2|Bacteria,2G6DM@200795|Chloroflexi 200795|Chloroflexi EGP PFAM major facilitator superfamily MFS_1 - - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1,MFS_1_like,Sugar_tr k59_87576_1 118161.KB235922_gene4668 1.13e-74 237.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - 3.5.1.53,6.3.5.1 ko:K01950,ko:K12251 ko00330,ko00760,ko01100,map00330,map00760,map01100 M00115 R00257,R01152 RC00010,RC00096,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase k59_578211_1 1123075.AUDP01000024_gene1086 3.57e-67 212.0 COG3718@1|root,COG3718@2|Bacteria,1TR6M@1239|Firmicutes,2491W@186801|Clostridia 186801|Clostridia G Myo-inositol catabolism protein IolB iolB - 5.3.1.30 ko:K03337 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08503 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_578211_2 1196029.ALIM01000049_gene4653 2.26e-28 110.0 COG1082@1|root,COG1082@2|Bacteria,1VCQ8@1239|Firmicutes,4IF2R@91061|Bacilli,1ZE41@1386|Bacillus 91061|Bacilli G Xylose isomerase-like TIM barrel - - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_803221_1 1347086.CCBA010000039_gene4865 1.71e-61 200.0 COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,4HB0Z@91061|Bacilli,1ZC27@1386|Bacillus 91061|Bacilli C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.27,1.1.1.37 ko:K00016,ko:K00024 ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R00703,R01000,R03104,R07136 RC00031,RC00044 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Ldh_1_C,Ldh_1_N k59_87579_1 1168034.FH5T_10180 1.69e-127 387.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,2FMFA@200643|Bacteroidia 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_578212_1 913325.N799_10695 8.31e-76 238.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X2XI@135614|Xanthomonadales 135614|Xanthomonadales I acyl-CoA dehydrogenase acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_350459_1 754436.JCM19237_922 3.91e-43 154.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,1RP7Q@1236|Gammaproteobacteria,1XUQR@135623|Vibrionales 135623|Vibrionales K Transcriptional regulator gcvA - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1034652_1 1168034.FH5T_10135 3.71e-35 134.0 COG0038@1|root,COG0038@2|Bacteria,4NZYS@976|Bacteroidetes,2G0DB@200643|Bacteroidia 976|Bacteroidetes P Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 k59_1034652_2 1168034.FH5T_10130 6.07e-23 92.8 2DVQJ@1|root,32UZZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_708798_1 458817.Shal_3364 3.98e-63 211.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,2QAED@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_315477_1 335543.Sfum_3868 1.17e-57 186.0 COG0703@1|root,COG0703@2|Bacteria,1NEB0@1224|Proteobacteria 1224|Proteobacteria E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate - - - - - - - - - - - - - k59_186771_1 1172190.M947_02275 6.57e-44 150.0 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,42MJW@68525|delta/epsilon subdivisions,2YN3R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_839350_2 1049564.TevJSym_ap00050 5.48e-97 307.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_219256_1 929562.Emtol_3604 1.57e-06 52.8 COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,47M5P@768503|Cytophagia 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_414073_1 1384056.N787_00935 2.46e-105 319.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1X2YB@135614|Xanthomonadales 135614|Xanthomonadales S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP k59_414074_1 1454004.AW11_01686 1.28e-68 223.0 COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,2VPV7@28216|Betaproteobacteria 28216|Betaproteobacteria K Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_708811_1 379066.GAU_3509 8.61e-84 254.0 COG1484@1|root,COG1484@2|Bacteria,1ZV5D@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bacterial dnaA protein - - - - - - - - - - - - IstB_IS21 k59_219261_1 1396141.BATP01000023_gene508 7.09e-45 165.0 COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,46TS1@74201|Verrucomicrobia,2ITZM@203494|Verrucomicrobiae 203494|Verrucomicrobiae T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_480164_2 1165841.SULAR_08532 3.49e-48 165.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2YMFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_546611_1 395493.BegalDRAFT_0739 1.94e-36 144.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,4604X@72273|Thiotrichales 72273|Thiotrichales T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_187473_1 864051.BurJ1DRAFT_4068 6.53e-85 277.0 COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1KIV3@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Succinyl-CoA ligase like flavodoxin domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_154952_1 1150600.ADIARSV_3234 3.85e-27 114.0 COG1234@1|root,COG1262@1|root,COG1234@2|Bacteria,COG1262@2|Bacteria,4NGWF@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF1566) - - - - - - - - - - - - DUF1566,Lactamase_B_2 k59_154952_2 1168034.FH5T_12525 5.72e-97 292.0 2CD20@1|root,2Z7SQ@2|Bacteria,4NEQ1@976|Bacteroidetes,2FWPF@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_677831_1 1123400.KB904768_gene3402 1.91e-46 160.0 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria,463K2@72273|Thiotrichales 72273|Thiotrichales P Helix-turn-helix domain - - - - - - - - - - - - HTH_17,PBP_like k59_420092_1 1286106.MPL1_08267 3.79e-82 252.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,460H0@72273|Thiotrichales 72273|Thiotrichales S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_944473_1 1168034.FH5T_00790 9.11e-73 244.0 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_809324_1 37659.JNLN01000001_gene1543 1.79e-21 93.6 COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia,36FVA@31979|Clostridiaceae 186801|Clostridia L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase k59_23739_1 1168034.FH5T_22130 1.92e-29 116.0 COG1452@1|root,COG1452@2|Bacteria,4NFWD@976|Bacteroidetes,2FM9F@200643|Bacteroidia 976|Bacteroidetes M Psort location OuterMembrane, score - - - - - - - - - - - - - k59_23739_2 869213.JCM21142_3824 1.32e-58 184.0 COG0251@1|root,COG0251@2|Bacteria,4NQ8M@976|Bacteroidetes,47QE4@768503|Cytophagia 976|Bacteroidetes J TIGRFAM endoribonuclease L-PSP ridA - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_257337_1 1123257.AUFV01000018_gene3696 2.19e-48 167.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1X39P@135614|Xanthomonadales 135614|Xanthomonadales P Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_389617_1 396588.Tgr7_0901 8.63e-17 73.6 COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,1SH40@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yjeT - - ko:K09937 - - - - ko00000 - - - DUF2065 k59_389617_2 765914.ThisiDRAFT_0368 4.94e-66 214.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1WW0U@135613|Chromatiales 135613|Chromatiales O HflC and HflK could regulate a protease - - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_454148_1 1168034.FH5T_17845 7.36e-57 193.0 COG4251@1|root,COG4251@2|Bacteria,4PMMC@976|Bacteroidetes 976|Bacteroidetes T N-terminal 7TM region of histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_7TM,PAS_9 k59_845195_1 1168034.FH5T_10795 2.01e-134 396.0 COG0608@1|root,COG0608@2|Bacteria,4NDW1@976|Bacteroidetes,2FMH0@200643|Bacteroidia 976|Bacteroidetes L single-stranded-DNA-specific exonuclease recJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_976311_2 1045855.DSC_04795 9.56e-34 132.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1X49W@135614|Xanthomonadales 135614|Xanthomonadales S mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth uup - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_650155_1 1501391.LG35_08605 4.86e-52 175.0 COG4152@1|root,COG4152@2|Bacteria,4NEJE@976|Bacteroidetes,2FMK3@200643|Bacteroidia,22V5K@171550|Rikenellaceae 976|Bacteroidetes S Domain of unknown function (DUF4162) natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_683295_1 887898.HMPREF0551_2028 3.09e-80 256.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,1K2GQ@119060|Burkholderiaceae 28216|Betaproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_257354_1 243233.MCA1475 5.64e-90 284.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1XEQR@135618|Methylococcales 135618|Methylococcales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1041780_1 1218076.BAYB01000004_gene804 1.08e-28 110.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,2W5BV@28216|Betaproteobacteria,1K5NQ@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_485166_1 381666.PHG101 5.88e-197 556.0 COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,2VKAK@28216|Betaproteobacteria,1K5RX@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3 k59_618079_2 985867.AEWF01000001_gene1756 5.59e-30 116.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,2TWYJ@28211|Alphaproteobacteria,47GTR@766|Rickettsiales 766|Rickettsiales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_746248_1 247639.MGP2080_06872 8.21e-66 206.0 COG4445@1|root,COG4445@2|Bacteria,1QMPR@1224|Proteobacteria,1RYZP@1236|Gammaproteobacteria 1236|Gammaproteobacteria FJ COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA - - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_23763_1 1355374.JARU01000006_gene1799 2.91e-07 52.8 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2YMHU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_23763_2 717774.Marme_1716 2.4e-68 211.0 COG0454@1|root,COG0456@2|Bacteria,1QUWI@1224|Proteobacteria,1T3VM@1236|Gammaproteobacteria,1XS8T@135619|Oceanospirillales 135619|Oceanospirillales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_976339_1 580332.Slit_2985 8.26e-05 43.5 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,44VTQ@713636|Nitrosomonadales 28216|Betaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_976339_2 95619.PM1_0229070 1.55e-46 157.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 OSCP k59_976339_3 580332.Slit_2983 1.22e-15 75.9 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,44V6D@713636|Nitrosomonadales 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1041791_1 1168034.FH5T_21215 2.38e-27 105.0 arCOG09511@1|root,2Z9DH@2|Bacteria,4NIMU@976|Bacteroidetes 976|Bacteroidetes S FRG - - - - - - - - - - - - FRG k59_1041791_3 319236.JCM19294_1209 3.79e-14 71.6 COG0500@1|root,COG0500@2|Bacteria,4NGY5@976|Bacteroidetes,1HXZX@117743|Flavobacteriia,3HM3S@363408|Nonlabens 976|Bacteroidetes Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_1010113_1 1249627.D779_4054 1.76e-91 286.0 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Alkaline phosphatase pafA - - - - - - - - - - - Phosphodiest k59_553814_1 715451.ambt_15225 1.07e-34 126.0 COG0652@1|root,COG0652@2|Bacteria,1REE3@1224|Proteobacteria,1S4BW@1236|Gammaproteobacteria,464R7@72275|Alteromonadaceae 1236|Gammaproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K03767 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_585761_1 867845.KI911784_gene3705 1.38e-12 70.5 COG0317@1|root,COG0317@2|Bacteria 2|Bacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_977258_1 572544.Ilyop_2899 6.75e-16 76.6 COG3177@1|root,COG3177@2|Bacteria 2|Bacteria D Filamentation induced by cAMP protein fic XK27_00240 - - - - - - - - - - - Fic,HTH_DeoR k59_977258_2 1414720.CBYM010000022_gene2196 2.82e-09 59.3 COG1669@1|root,COG1669@2|Bacteria,1UGM2@1239|Firmicutes,24PS8@186801|Clostridia,36KT9@31979|Clostridiaceae 186801|Clostridia S Nucleotidyltransferase domain - - - - - - - - - - - - NTP_transf_2 k59_977258_3 857293.CAAU_0746 4.44e-06 47.0 COG2445@1|root,COG2445@2|Bacteria,1V6HC@1239|Firmicutes,24M25@186801|Clostridia,36J8T@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF86 - - - - - - - - - - - - DUF86 k59_127620_1 742767.HMPREF9456_01157 1.29e-59 193.0 COG2045@1|root,COG2045@2|Bacteria,4NG1A@976|Bacteroidetes,2FSD1@200643|Bacteroidia,22ZAW@171551|Porphyromonadaceae 976|Bacteroidetes H 2-phosphosulpholactate phosphatase comB - 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp k59_194156_1 1122201.AUAZ01000042_gene1270 8.44e-123 360.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,465EU@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_684185_1 1218352.B597_005050 8e-77 239.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1Z016@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760 Coprogen_oxidas k59_715741_1 1249627.D779_0278 2e-75 233.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales 135613|Chromatiales S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_715741_2 314278.NB231_05811 1.35e-165 477.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_485738_1 326298.Suden_1573 9.02e-15 68.9 2E94U@1|root,333DN@2|Bacteria,1P6X3@1224|Proteobacteria,42TTX@68525|delta/epsilon subdivisions,2YPST@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_1010125_1 749222.Nitsa_2065 1.73e-15 75.1 COG0115@1|root,COG0115@2|Bacteria,1N3ZD@1224|Proteobacteria,42TNN@68525|delta/epsilon subdivisions,2YPU5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH Branched-chain amino acid aminotransferase - - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k59_1010125_2 1165841.SULAR_09449 1.61e-70 221.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2YMRZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_420782_1 935840.JAEQ01000004_gene391 2.44e-67 225.0 COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,2TTR0@28211|Alphaproteobacteria,43HQ4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain ptrB GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_810343_1 765911.Thivi_1828 5.4e-33 127.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales 135613|Chromatiales S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_846020_1 1168034.FH5T_04500 3.66e-26 98.2 COG0864@1|root,COG0864@2|Bacteria 2|Bacteria K response to nickel cation nikR GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016151,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_357348_1 595494.Tola_1620 4.5e-48 155.0 COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,1S8UP@1236|Gammaproteobacteria,1Y5UY@135624|Aeromonadales 135624|Aeromonadales E Belongs to the urease beta subunit family ureB - 3.5.1.5 ko:K01429 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_beta k59_357348_2 1123401.JHYQ01000013_gene611 4.17e-44 157.0 COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,1RN78@1236|Gammaproteobacteria,45ZMK@72273|Thiotrichales 72273|Thiotrichales E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Amidohydro_1,Urease_alpha k59_553841_1 933262.AXAM01000018_gene1020 3.65e-38 134.0 COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MI1A@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_618743_1 1120965.AUBV01000004_gene1037 7.8e-26 106.0 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47U6P@768503|Cytophagia 976|Bacteroidetes T SnoaL-like domain - - - - - - - - - - - - HATPase_c,HisKA,SnoaL_3 k59_911626_1 1250006.JHZZ01000001_gene2073 1.48e-60 200.0 COG1253@1|root,COG1253@2|Bacteria,4NG0I@976|Bacteroidetes,1HWV0@117743|Flavobacteriia,3VV3V@52959|Polaribacter 976|Bacteroidetes P Transporter associated domain tlyC - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_618750_1 768671.ThimaDRAFT_0226 2.13e-91 282.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1WVZV@135613|Chromatiales 135613|Chromatiales P PFAM Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_485753_1 1128398.Curi_c24040 5.33e-224 634.0 COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia,267Y7@186813|unclassified Clostridiales 186801|Clostridia C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k59_321957_1 519989.ECTPHS_09078 2.65e-11 63.2 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1WX3Q@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_321957_2 203122.Sde_2901 1.82e-16 77.8 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_684236_1 563040.Saut_2142 4.41e-116 347.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2YMUF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_945231_1 1265313.HRUBRA_01483 6.69e-49 169.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1J4SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Permease lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_715774_1 1454004.AW11_02488 1.6e-36 136.0 COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria 2|Bacteria P negative regulation of phosphate transmembrane transport phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 1.20.4.1,3.1.3.48 ko:K01104,ko:K02039,ko:K03741 - - - - ko00000,ko01000 - - - PhoU k59_60588_1 1500897.JQNA01000002_gene2988 4.18e-10 67.0 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VICN@28216|Betaproteobacteria,1K63V@119060|Burkholderiaceae 28216|Betaproteobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,Pkinase k59_357367_1 765912.Thimo_3457 3.25e-54 174.0 COG1487@1|root,COG1487@2|Bacteria,1RCQ1@1224|Proteobacteria,1S2N6@1236|Gammaproteobacteria,1X14B@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4411) - - - - - - - - - - - - DUF4411 k59_357367_2 270374.MELB17_21141 6.31e-78 243.0 COG1396@1|root,COG2856@1|root,COG1396@2|Bacteria,COG2856@2|Bacteria,1PFUN@1224|Proteobacteria,1RR40@1236|Gammaproteobacteria,46AVB@72275|Alteromonadaceae 1236|Gammaproteobacteria E Transcriptional regulators - - - - - - - - - - - - Peptidase_M78 k59_911639_1 640081.Dsui_0539 1.35e-29 114.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,2KU8W@206389|Rhodocyclales 206389|Rhodocyclales P ABC-type Fe3 -hydroxamate transport system, periplasmic component - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_585797_1 1168034.FH5T_16915 7.19e-74 234.0 COG0303@1|root,COG0303@2|Bacteria,4NDYD@976|Bacteroidetes 976|Bacteroidetes H Molybdenum cofactor synthesis domain moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_977311_1 1121405.dsmv_3081 2.27e-45 152.0 2C8DW@1|root,32RKY@2|Bacteria,1MZUD@1224|Proteobacteria,432NJ@68525|delta/epsilon subdivisions 1224|Proteobacteria S Domain of unknown function (DUF3597) - - - - - - - - - - - - DUF3597 k59_455161_1 762982.HMPREF9442_01574 6.15e-16 82.4 COG2335@1|root,COG2335@2|Bacteria,4NH49@976|Bacteroidetes,2FPBD@200643|Bacteroidia 976|Bacteroidetes M Fasciclin domain - - - ko:K19519 - - - - ko00000,ko04516 - - - Fasciclin k59_455161_2 762968.HMPREF9441_01820 6.38e-09 61.2 COG2335@1|root,COG2335@2|Bacteria,4NUVQ@976|Bacteroidetes,2FRKE@200643|Bacteroidia 976|Bacteroidetes M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin k59_585804_1 216595.PFLU_2552 1.14e-64 225.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1YQ2C@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q Condensation domain - - - ko:K15659 - - - - ko00000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_846048_1 1168034.FH5T_16945 1.95e-95 292.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT,Cytochrom_c3_2 k59_289349_1 1123278.KB893511_gene1443 6.05e-45 162.0 COG2272@1|root,COG2272@2|Bacteria,4NF5N@976|Bacteroidetes,47MRG@768503|Cytophagia 976|Bacteroidetes I Carboxylesterase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_485778_1 105559.Nwat_2757 0.000748 41.2 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1WXVZ@135613|Chromatiales 135613|Chromatiales C Belongs to the AlaDH PNT family - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_485778_2 380703.AHA_1863 8.48e-46 158.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1Y3MS@135624|Aeromonadales 135624|Aeromonadales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_226482_1 926692.AZYG01000082_gene549 6.89e-171 500.0 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3WACD@53433|Halanaerobiales 186801|Clostridia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_226482_2 572544.Ilyop_1273 2.42e-146 426.0 COG0592@1|root,COG0592@2|Bacteria,378DJ@32066|Fusobacteria 32066|Fusobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_226482_3 572544.Ilyop_1274 9.01e-148 421.0 COG0568@1|root,COG0568@2|Bacteria,378VX@32066|Fusobacteria 32066|Fusobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_226482_4 596323.HMPREF0554_2054 4.06e-36 132.0 COG0240@1|root,COG0240@2|Bacteria,378MQ@32066|Fusobacteria 32066|Fusobacteria I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_357378_1 1049564.TevJSym_bc00310 3.44e-110 323.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria KO Hydrogenase accessory protein HypB hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_127686_1 744980.TRICHSKD4_4379 2.9e-26 114.0 COG2931@1|root,COG2931@2|Bacteria,1QZD0@1224|Proteobacteria,2US2T@28211|Alphaproteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - EF-hand_5 k59_194253_1 446466.Cfla_2262 3.96e-69 212.0 arCOG11412@1|root,31S84@2|Bacteria,2IHRW@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_194253_2 446466.Cfla_2261 4.47e-16 72.8 2DVEK@1|root,33VIT@2|Bacteria,2IG5Q@201174|Actinobacteria 201174|Actinobacteria S T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k59_553901_1 1168034.FH5T_08275 4.89e-153 451.0 COG1882@1|root,COG1882@2|Bacteria,4NDWW@976|Bacteroidetes,2FMC2@200643|Bacteroidia 976|Bacteroidetes C Psort location Cytoplasmic, score 9.97 - - 2.3.1.54,4.1.1.83 ko:K00656,ko:K18427 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_420826_1 1123514.KB905899_gene1880 1.65e-70 219.0 COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,4638B@72273|Thiotrichales 72273|Thiotrichales S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_650832_1 338966.Ppro_1721 5.89e-19 87.0 COG2766@1|root,COG2766@2|Bacteria,1NG7R@1224|Proteobacteria,42P8B@68525|delta/epsilon subdivisions,2WJIU@28221|Deltaproteobacteria,43S2Z@69541|Desulfuromonadales 28221|Deltaproteobacteria T PrkA serine protein kinase C-terminal domain - - - - - - - - - - - - AAA_PrkA,PrkA k59_650832_2 933262.AXAM01000038_gene916 8.31e-24 101.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,42MYY@68525|delta/epsilon subdivisions,2WJ6V@28221|Deltaproteobacteria,2MI2N@213118|Desulfobacterales 28221|Deltaproteobacteria S SpoVR like protein spoVR - - ko:K06415 - - - - ko00000 - - - SpoVR k59_495274_1 1165841.SULAR_06473 1.67e-102 308.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2YMID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_200642_1 748449.Halha_1142 9.28e-133 396.0 COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,3WB77@53433|Halanaerobiales 186801|Clostridia G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1,HHH_3 k59_200642_2 702450.CUW_1536 6.4e-185 527.0 COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,3VNSK@526524|Erysipelotrichia 526524|Erysipelotrichia H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - - - - - - - - - - - Hexapep,NTP_transferase k59_658954_1 749222.Nitsa_1757 2.72e-93 275.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42Q27@68525|delta/epsilon subdivisions,2YNR3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C molybdopterin oxidoreductase - - - - - - - - - - - - Fer4_11,Fer4_3 k59_756047_1 572544.Ilyop_1329 2.01e-90 295.0 COG2176@1|root,COG2176@2|Bacteria,378MN@32066|Fusobacteria 32066|Fusobacteria L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T k59_462929_1 1121439.dsat_2171 1.32e-38 147.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WMD3@28221|Deltaproteobacteria,2M7W1@213115|Desulfovibrionales 28221|Deltaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_462929_2 768671.ThimaDRAFT_3374 1.09e-13 69.7 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,1RRH4@1236|Gammaproteobacteria,1X2HQ@135613|Chromatiales 135613|Chromatiales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_331960_1 1249627.D779_4058 1.55e-17 75.5 2BRPS@1|root,32KPD@2|Bacteria,1PAWY@1224|Proteobacteria,1STPX@1236|Gammaproteobacteria,1X1Q8@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_331960_2 1165096.ARWF01000001_gene1974 8.53e-08 57.4 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2VHI3@28216|Betaproteobacteria,2KKKB@206350|Nitrosomonadales 206350|Nitrosomonadales I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_200655_2 387093.SUN_1765 1.31e-39 137.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,42SBG@68525|delta/epsilon subdivisions,2YP68@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM AMMECR1 domain protein - - - ko:K09141 - - - - ko00000 - - - AMMECR1 k59_331963_1 498211.CJA_1512 6.9e-64 206.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,1RP49@1236|Gammaproteobacteria,1FGXD@10|Cellvibrio 1236|Gammaproteobacteria E Saccharopine dehydrogenase C-terminal domain HA62_29220 - 1.5.1.43,1.5.1.7 ko:K00290,ko:K13746 ko00300,ko00310,ko00330,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map00330,map01100,map01110,map01130,map01230 M00030,M00032 R00715,R09079,R09080 RC00053,RC00217,RC00225,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_756051_1 234831.PSM_A0765 2.36e-24 109.0 COG1819@1|root,COG1819@2|Bacteria,1PJJ9@1224|Proteobacteria,1S07B@1236|Gammaproteobacteria,2PZVX@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria CG glycosyl - - - - - - - - - - - - - k59_495291_1 883126.HMPREF9710_03453 3.07e-09 64.3 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VPAC@28216|Betaproteobacteria,4766N@75682|Oxalobacteraceae 28216|Betaproteobacteria T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_298533_1 439235.Dalk_5087 8.74e-117 348.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales 1224|Proteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_625775_1 1049564.TevJSym_au00160 3.57e-150 442.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1J4XK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_364351_1 596151.DesfrDRAFT_1014 1.24e-46 173.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MH92@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,CHASE,DUF3365,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,PilJ,Response_reg,dCache_1 k59_985199_1 568706.BN118_1737 2.37e-103 311.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,3T1KN@506|Alcaligenaceae 28216|Betaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_985199_2 1230343.CANP01000020_gene1387 6.77e-31 112.0 COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1SAUS@1236|Gammaproteobacteria,1JEIT@118969|Legionellales 118969|Legionellales H 4-alpha-hydroxytetrahydrobiopterin dehydratase activity phs - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_495293_1 926550.CLDAP_26220 5.93e-23 97.8 COG1879@1|root,COG1879@2|Bacteria,2G6R2@200795|Chloroflexi 200795|Chloroflexi G Periplasmic binding proteins and sugar binding domain of LacI family - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_495293_2 1441629.PCH70_17530 5.88e-48 169.0 COG1879@1|root,COG1879@2|Bacteria,1MWGU@1224|Proteobacteria,1RPE9@1236|Gammaproteobacteria,1Z4SN@136849|Pseudomonas syringae group 1236|Gammaproteobacteria G Periplasmic binding proteins and sugar binding domain of LacI family mglB GO:0005575,GO:0005623,GO:0006810,GO:0006935,GO:0008150,GO:0008643,GO:0008645,GO:0009605,GO:0015749,GO:0015757,GO:0015765,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:1901264,GO:1901656 - ko:K10439,ko:K10540,ko:K17205,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00214,M00591,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.15,3.A.1.2.19,3.A.1.2.3 - iPC815.YPO1507 Peripla_BP_4 k59_592638_1 768671.ThimaDRAFT_1750 2.01e-53 172.0 COG0852@1|root,COG0852@2|Bacteria,1RB4M@1224|Proteobacteria,1S3KE@1236|Gammaproteobacteria,1WY1J@135613|Chromatiales 135613|Chromatiales C NADH ubiquinone oxidoreductase - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_592638_2 768671.ThimaDRAFT_1749 1.37e-17 79.7 COG0377@1|root,COG0377@2|Bacteria,1Q273@1224|Proteobacteria,1S0ZH@1236|Gammaproteobacteria,1WXWF@135613|Chromatiales 135613|Chromatiales C PFAM NADH Ubiquinone - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_168766_1 1242864.D187_009199 6.99e-25 99.8 COG0331@1|root,COG1767@1|root,COG0331@2|Bacteria,COG1767@2|Bacteria 2|Bacteria H triphosphoribosyl-dephospho-CoA synthase activity fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180,2.3.1.39,2.4.2.52,2.7.7.61 ko:K00645,ko:K00648,ko:K05966,ko:K13927,ko:K13930 ko00061,ko00333,ko01100,ko01130,ko01212,ko02020,map00061,map00333,map01100,map01130,map01212,map02020 M00082,M00083 R01626,R09675,R10706,R10707,R11671 RC00004,RC00039,RC00049,RC00063,RC02727,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1,CitG k59_168766_2 543728.Vapar_5369 3.3e-25 103.0 COG1767@1|root,COG1767@2|Bacteria,1NB3R@1224|Proteobacteria,2VJZ4@28216|Betaproteobacteria,4ADM3@80864|Comamonadaceae 28216|Betaproteobacteria F Involved in the formation of 2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase mdcB - 2.4.2.52 ko:K13930 - - R09675 RC00049,RC00063 ko00000,ko01000 - - - CitG k59_625780_1 1121878.AUGL01000021_gene2784 7.94e-100 295.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,1RMF7@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the GST superfamily yfcG - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N k59_233657_1 177437.HRM2_39080 4.3e-36 128.0 COG3821@1|root,COG3821@2|Bacteria,1Q4XJ@1224|Proteobacteria,4303B@68525|delta/epsilon subdivisions,2WVIU@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function, DUF599 - - - - - - - - - - - - DUF599 k59_233657_2 338963.Pcar_2836 2.4e-78 245.0 COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,42MZG@68525|delta/epsilon subdivisions,2WKZ3@28221|Deltaproteobacteria,43UBA@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_168769_1 713587.THITH_05130 1.95e-72 231.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales 135613|Chromatiales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_331983_1 563040.Saut_1791 6.12e-150 443.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2YMVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_592645_1 572480.Arnit_1584 6.57e-50 170.0 COG0697@1|root,COG0697@2|Bacteria,1PIFB@1224|Proteobacteria,42QAN@68525|delta/epsilon subdivisions,2YNGI@29547|Epsilonproteobacteria 2|Bacteria EG integral membrane protein (DUF6 domain protein) - - - - - - - - - - - - EamA k59_495307_2 1168034.FH5T_08605 1.08e-29 109.0 COG2153@1|root,COG2153@2|Bacteria,4NQPR@976|Bacteroidetes,2FU39@200643|Bacteroidia 976|Bacteroidetes S Acetyltransferase, gnat family elaA - - ko:K02348 - - - - ko00000 - - - Acetyltransf_10 k59_69986_2 452471.Aasi_1044 1.76e-17 83.2 COG0168@1|root,COG0168@2|Bacteria,4NF7R@976|Bacteroidetes,47JIP@768503|Cytophagia 976|Bacteroidetes P PFAM Cation transport protein - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_36982_1 1168034.FH5T_11965 4.15e-143 416.0 COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,2FS28@200643|Bacteroidia 976|Bacteroidetes E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_592650_1 768671.ThimaDRAFT_2363 4.71e-68 221.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_233669_1 497964.CfE428DRAFT_5240 9.42e-57 185.0 COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia 74201|Verrucomicrobia S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_200683_1 387092.NIS_1751 6.65e-35 132.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2YN4S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_756078_1 237368.SCABRO_01037 1.1e-25 111.0 COG3696@1|root,COG3696@2|Bacteria,2IY1K@203682|Planctomycetes 203682|Planctomycetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_364374_2 326297.Sama_0227 3.23e-57 181.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,2QBN5@267890|Shewanellaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_724217_1 639282.DEFDS_1394 2.13e-47 173.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GEXA@200930|Deferribacteres 200930|Deferribacteres C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8 k59_495717_1 485917.Phep_0226 2.35e-24 106.0 COG1629@1|root,COG2373@1|root,COG1629@2|Bacteria,COG2373@2|Bacteria,4NG2S@976|Bacteroidetes,1IQ4C@117747|Sphingobacteriia 976|Bacteroidetes Q COG2373 Large extracellular alpha-helical protein - - - - - - - - - - - - A2M_N,Plug k59_299023_1 634500.EbC_21260 9.41e-89 275.0 COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,1RN4R@1236|Gammaproteobacteria,3X7Z3@551|Erwinia 1236|Gammaproteobacteria C radical SAM domain protein aslB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_169404_1 1165841.SULAR_05978 1.48e-24 102.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2YMX4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_169404_2 1244531.CIG1485E_0800 3.39e-30 114.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2YNEP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_332527_1 1168034.FH5T_10830 8.11e-77 231.0 COG0041@1|root,COG0041@2|Bacteria,4NME9@976|Bacteroidetes,2FMWN@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_397605_1 335543.Sfum_1863 4.42e-91 272.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2MQ5V@213462|Syntrophobacterales 28221|Deltaproteobacteria S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_953064_1 439235.Dalk_4515 1.26e-53 185.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_332530_1 1122599.AUGR01000013_gene819 4.01e-94 295.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XIJU@135619|Oceanospirillales 135619|Oceanospirillales V (ABC) transporter - - - ko:K11004,ko:K13409 ko02010,ko03070,ko04626,ko05133,map02010,map03070,map04626,map05133 M00325,M00339,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2,3.A.1.110 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_266286_1 1168034.FH5T_05235 7.98e-63 209.0 COG5010@1|root,COG5010@2|Bacteria,4PMJW@976|Bacteroidetes,2G0E2@200643|Bacteroidia 976|Bacteroidetes U COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_8 k59_756526_1 1168034.FH5T_05740 3.12e-50 179.0 COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,2FN0V@200643|Bacteroidia 976|Bacteroidetes G Glycoside hydrolase family 3 - - - - - - - - - - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C k59_70562_1 1500890.JQNL01000001_gene225 4.52e-76 242.0 COG0639@1|root,COG0639@2|Bacteria,1QE1Y@1224|Proteobacteria,1RRG9@1236|Gammaproteobacteria,1X5YH@135614|Xanthomonadales 135614|Xanthomonadales T Calcineurin-like phosphoesterase - - - - - - - - - - - - AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase k59_169423_1 398512.JQKC01000021_gene3717 1.58e-91 272.0 COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,25Q3T@186801|Clostridia,3WGXN@541000|Ruminococcaceae 186801|Clostridia H Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG ureG - - ko:K03189 - - - - ko00000 - - - cobW k59_103706_1 1168034.FH5T_07610 3.12e-84 271.0 COG3533@1|root,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes,2FN3P@200643|Bacteroidia 976|Bacteroidetes V protein conserved in bacteria - - - ko:K09955 - - - - ko00000 - - - DUF4986,Glyco_hydro_127 k59_626351_1 1049564.TevJSym_aw00170 6.96e-77 231.0 COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the DsrF TusC family tusC GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - ko:K07236 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DrsE k59_626351_2 1049564.TevJSym_aw00160 1.96e-34 120.0 COG2168@1|root,COG2168@2|Bacteria 2|Bacteria P tRNA wobble position uridine thiolation tusB GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - ko:K07237 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DsrH k59_234152_1 575609.HMPREF0629_00579 6.85e-77 237.0 COG3103@1|root,COG4991@2|Bacteria,1V4Q0@1239|Firmicutes,24G0J@186801|Clostridia 186801|Clostridia T sh3 domain protein - - - - - - - - - - - - DUF285 k59_234152_3 572544.Ilyop_0949 3.08e-315 867.0 COG0488@1|root,COG0488@2|Bacteria,37BQZ@32066|Fusobacteria 32066|Fusobacteria S ABC transporter, ATP-binding protein - - - - - - - - - - - - ABC_tran k59_234152_4 1319815.HMPREF0202_00812 1.89e-201 566.0 COG3842@1|root,COG3842@2|Bacteria,3788D@32066|Fusobacteria 32066|Fusobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_234152_5 1121346.KB899837_gene1271 1.13e-48 173.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,4HB9M@91061|Bacilli,26T5I@186822|Paenibacillaceae 91061|Bacilli K Transcriptional regulator degA - - - - - - - - - - - LacI,Peripla_BP_3 k59_234152_6 935837.JAEK01000020_gene587 8.83e-176 507.0 COG1653@1|root,COG1653@2|Bacteria,1TR8U@1239|Firmicutes,4HF2W@91061|Bacilli,1ZFQS@1386|Bacillus 91061|Bacilli G Bacterial extracellular solute-binding protein msmE - - ko:K10120 - M00197 - - ko00000,ko00002,ko02000 3.A.1.1.20 - - SBP_bac_1,SBP_bac_8 k59_234152_7 935837.JAEK01000020_gene588 6.44e-141 407.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,4IQMX@91061|Bacilli,1ZRME@1386|Bacillus 91061|Bacilli P Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K10121 - M00197,M00207 - - ko00000,ko00002,ko02000 3.A.1.1,3.A.1.1.20 - - BPD_transp_1 k59_234152_8 580331.Thit_2109 2.74e-83 258.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,249NY@186801|Clostridia,42FU1@68295|Thermoanaerobacterales 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K10122,ko:K17243 ko02010,map02010 M00197,M00600 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.20,3.A.1.1.39 - - BPD_transp_1 k59_234152_9 1319815.HMPREF0202_00232 4.18e-163 475.0 COG1621@1|root,COG1621@2|Bacteria,37BD2@32066|Fusobacteria 32066|Fusobacteria G Glycosyl hydrolases family 32 - - - - - - - - - - - - Glyco_hydro_32C,Glyco_hydro_32N k59_234152_10 1235790.C805_03597 1.15e-59 202.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,25X36@186806|Eubacteriaceae 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k59_234152_11 1196029.ALIM01000030_gene850 1.03e-154 457.0 COG1621@1|root,COG1621@2|Bacteria,1TS4M@1239|Firmicutes,4HC82@91061|Bacilli,1ZPVF@1386|Bacillus 91061|Bacilli G Belongs to the glycosyl hydrolase 32 family sacC1 GO:0003674,GO:0003824,GO:0004553,GO:0004564,GO:0005975,GO:0005984,GO:0005985,GO:0005987,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575 3.2.1.80 ko:K03332 ko00051,map00051 - R00879 - ko00000,ko00001,ko01000 - - - Big_2,Cadherin-like,Glyco_hydro_32C,Glyco_hydro_32N k59_234152_12 610130.Closa_2326 3.8e-77 253.0 COG1653@1|root,COG1653@2|Bacteria,1TQJE@1239|Firmicutes,2496C@186801|Clostridia,223Y9@1506553|Lachnoclostridium 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_8 k59_234152_13 1274374.CBLK010000059_gene469 1.63e-110 329.0 COG1175@1|root,COG1175@2|Bacteria,1TQB1@1239|Firmicutes,4HDV6@91061|Bacilli,26UHU@186822|Paenibacillaceae 91061|Bacilli P Sugar ABC transporter permease msmF - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 k59_234152_14 592026.GCWU0000282_002322 1.42e-106 317.0 COG0395@1|root,COG0395@2|Bacteria,1UYHV@1239|Firmicutes,25C4Q@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 k59_921030_2 387093.SUN_0014 3.95e-256 716.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2YMTY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Mg chelatase-related protein comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_397622_1 620914.JH621271_gene1737 9.71e-177 509.0 COG3039@1|root,COG3039@2|Bacteria,4NGW9@976|Bacteroidetes,1HZ0D@117743|Flavobacteriia 976|Bacteroidetes L PFAM Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1_2,DUF772 k59_756535_2 946483.Cenrod_0905 3.93e-24 101.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,4AA7R@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM molybdopterin binding domain yfaY - - - - - - - - - - - MoCF_biosynth k59_528813_1 861299.J421_0144 1.93e-66 216.0 COG1004@1|root,COG1004@2|Bacteria,1ZTH3@142182|Gemmatimonadetes 2|Bacteria M UDP binding domain ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_659560_1 1278073.MYSTI_04285 3.43e-43 152.0 COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,42MA1@68525|delta/epsilon subdivisions,2WPWQ@28221|Deltaproteobacteria,2Z1GV@29|Myxococcales 28221|Deltaproteobacteria EJ Asparaginase ansB - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_789702_2 713587.THITH_03495 4.04e-65 214.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1WX9G@135613|Chromatiales 135613|Chromatiales C PFAM Malic enzyme, NAD binding domain - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_136574_1 555779.Dthio_PD1848 4.07e-123 374.0 COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,430KD@68525|delta/epsilon subdivisions,2WVSS@28221|Deltaproteobacteria 28221|Deltaproteobacteria L High confidence in function and specificity - - - - - - - - - - - - DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind k59_822656_2 1356852.N008_01240 6.73e-20 88.2 COG4874@1|root,COG4874@2|Bacteria,4NFG3@976|Bacteroidetes,47KEY@768503|Cytophagia 976|Bacteroidetes S Amidinotransferase - - - - - - - - - - - - Amidinotransf k59_37555_1 572544.Ilyop_1504 1.87e-147 429.0 COG1530@1|root,COG1530@2|Bacteria,378E6@32066|Fusobacteria 32066|Fusobacteria J Ribonuclease E/G family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G k59_429661_1 1184267.A11Q_764 9.99e-42 154.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,42UH9@68525|delta/epsilon subdivisions,2MTUE@213481|Bdellovibrionales,2WQRP@28221|Deltaproteobacteria 213481|Bdellovibrionales P Voltage gated chloride channel - - - - - - - - - - - - Voltage_CLC k59_463589_1 2340.JV46_11760 4.13e-102 303.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1J4K1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the peptidase M48B family htpX GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_463589_2 999141.GME_02455 3.36e-30 119.0 COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1XI68@135619|Oceanospirillales 135619|Oceanospirillales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-1 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_593199_1 1201290.M902_1895 3.39e-30 120.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,42N4K@68525|delta/epsilon subdivisions,2WK97@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM HI0933 family protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_855839_1 1415774.U728_2844 4.07e-69 223.0 COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36DRC@31979|Clostridiaceae 186801|Clostridia C FAD linked oxidase domain protein glcD1 - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_137257_1 1187851.A33M_4208 5.2e-84 264.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum 28211|Alphaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_398025_1 572544.Ilyop_0372 5.28e-88 271.0 COG0772@1|root,COG0772@2|Bacteria,3783Y@32066|Fusobacteria 32066|Fusobacteria D Belongs to the SEDS family mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_398025_2 314292.VAS14_17871 0.000392 43.1 COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,1SC8W@1236|Gammaproteobacteria,1XXVX@135623|Vibrionales 135623|Vibrionales D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE k59_398025_3 1449126.JQKL01000013_gene3431 8.17e-108 319.0 COG2894@1|root,COG2894@2|Bacteria,1TP6P@1239|Firmicutes,249BB@186801|Clostridia,2682J@186813|unclassified Clostridiales 186801|Clostridia D ATPase MipZ minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_398025_4 1408439.JHXW01000003_gene1456 3.54e-166 479.0 COG0612@1|root,COG0612@2|Bacteria,3785R@32066|Fusobacteria 32066|Fusobacteria S Belongs to the peptidase M16 family - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_398025_5 469616.FMAG_01298 7.92e-86 270.0 COG0795@1|root,COG0795@2|Bacteria,379E6@32066|Fusobacteria 32066|Fusobacteria S Permease, YjgP YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_398025_6 1319815.HMPREF0202_01416 4.51e-104 315.0 COG0795@1|root,COG0795@2|Bacteria,378KF@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_757115_1 84531.JMTZ01000009_gene3237 3.94e-116 340.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1X39D@135614|Xanthomonadales 135614|Xanthomonadales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_757115_2 1123377.AUIV01000001_gene1030 5.85e-11 60.8 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1X4HM@135614|Xanthomonadales 135614|Xanthomonadales E Histidine biosynthesis bifunctional protein HisIE hisI - 3.5.4.19,3.6.1.31 ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_855850_1 693746.OBV_16490 5.88e-21 86.7 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483,ko:K07497 - - - - ko00000 - - - DUF1153,HTH_28,HTH_Tnp_1,rve k59_855850_2 1128398.Curi_c00320 5.2e-38 136.0 COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,2487W@186801|Clostridia,269WM@186813|unclassified Clostridiales 186801|Clostridia L Integrase core domain - - - - - - - - - - - - HTH_21,rve k59_299573_1 95619.PM1_0201450 0.000193 43.5 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_299573_2 754477.Q7C_1790 1.18e-102 328.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,45ZWK@72273|Thiotrichales 72273|Thiotrichales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_234715_1 157072.XP_008861628.1 1.08e-38 150.0 COG0265@1|root,KOG1421@2759|Eukaryota 2759|Eukaryota O serine-type endopeptidase activity DEG7 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0010109,GO:0010205,GO:0016787,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1905156 - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_104390_1 1168034.FH5T_15130 2.43e-81 254.0 COG2755@1|root,COG2755@2|Bacteria,4NHT6@976|Bacteroidetes,2G37X@200643|Bacteroidia 976|Bacteroidetes E lipolytic protein G-D-S-L family - - - - - - - - - - - - Lipase_GDSL,Lipase_GDSL_2 k59_790120_2 1249627.D779_1971 1.53e-52 181.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales 135613|Chromatiales L PFAM Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_855856_1 1165841.SULAR_05438 1.1e-91 282.0 COG0665@1|root,COG0665@2|Bacteria,1Q0BQ@1224|Proteobacteria,42RXA@68525|delta/epsilon subdivisions,2YP66@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E COGs COG0665 Glycine D-amino acid oxidase (deaminating) - - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO k59_201811_1 1333507.AUTQ01000081_gene957 1.99e-35 136.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,2Q0J3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG2202 FOG PAS PAC domain - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_201811_2 525898.Sdel_1501 8.3e-86 279.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,43BP0@68525|delta/epsilon subdivisions,2YTEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LV TaqI-like C-terminal specificity domain - - - - - - - - - - - - N6_Mtase,TaqI_C k59_593842_1 1336243.JAEA01000003_gene2251 8.79e-12 65.1 2CER5@1|root,30H2I@2|Bacteria,1RCQ6@1224|Proteobacteria,2U5TX@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_593842_2 358681.BBR47_28280 8.63e-186 528.0 COG0477@1|root,COG2814@2|Bacteria,1UZTY@1239|Firmicutes,4HESQ@91061|Bacilli,26TEP@186822|Paenibacillaceae 91061|Bacilli EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_593842_3 358681.BBR47_28220 2.4e-207 586.0 COG4408@1|root,COG4408@2|Bacteria,1V010@1239|Firmicutes,4HFD3@91061|Bacilli,26QQW@186822|Paenibacillaceae 91061|Bacilli S Staphylopine dehydrogenase - - - - - - - - - - - - Staph_opine_DH k59_593842_4 358681.BBR47_28210 9.29e-116 340.0 COG4123@1|root,COG4123@2|Bacteria,1UJ5X@1239|Firmicutes,4IT37@91061|Bacilli,26V74@186822|Paenibacillaceae 91061|Bacilli S Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - - - - - - - - - - Methyltransf_31,NAS k59_593842_5 272558.10174690 8.41e-119 348.0 COG0253@1|root,COG0253@2|Bacteria,1V77F@1239|Firmicutes,4IT36@91061|Bacilli,1ZJI3@1386|Bacillus 91061|Bacilli E COG0253 Diaminopimelate epimerase - - - - - - - - - - - - - k59_593842_6 1355374.JARU01000009_gene11 1.14e-222 645.0 COG4773@1|root,COG4773@2|Bacteria,1QTT0@1224|Proteobacteria,43CB5@68525|delta/epsilon subdivisions,2YTAS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_593842_7 367737.Abu_2284 2.73e-87 267.0 COG5266@1|root,COG5266@2|Bacteria,1R7XS@1224|Proteobacteria,42TJD@68525|delta/epsilon subdivisions 1224|Proteobacteria P Domain of unknown function (DUF4198) - - - - - - - - - - - - DUF4198 k59_593842_8 1442598.JABW01000024_gene1548 2.63e-25 100.0 COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2YPGS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp k59_887728_1 1049564.TevJSym_ag01030 1.84e-78 248.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1J5DY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_724823_1 349124.Hhal_2413 1.96e-37 135.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1WXUX@135613|Chromatiales 135613|Chromatiales I 6-phosphogluconate dehydrogenase, NAD-binding - - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_267596_1 1077972.ARGLB_080_01600 7.76e-20 85.9 COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria 201174|Actinobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K06996 - - - - ko00000 - - - Glyoxalase k59_267596_2 572544.Ilyop_1147 1.34e-44 153.0 COG1897@1|root,COG1897@2|Bacteria,378EM@32066|Fusobacteria 32066|Fusobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metAA - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,HTS k59_72285_1 933262.AXAM01000027_gene2098 1.69e-65 204.0 COG1633@1|root,COG1633@2|Bacteria,1RGYD@1224|Proteobacteria,42T5E@68525|delta/epsilon subdivisions,2WPKD@28221|Deltaproteobacteria,2MKDK@213118|Desulfobacterales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_138090_1 765911.Thivi_0625 2.09e-14 68.9 2E5B5@1|root,33039@2|Bacteria,1NDK8@1224|Proteobacteria,1SFKE@1236|Gammaproteobacteria,1WZDR@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_138090_2 1042377.AFPJ01000037_gene3010 1.54e-90 276.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,464PR@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0032775,GO:0034641,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140096,GO:0140097,GO:1901360,GO:1901564 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_38617_1 706587.Desti_1174 1.94e-47 157.0 COG2204@1|root,COG2204@2|Bacteria,1RKC4@1224|Proteobacteria,42SJ3@68525|delta/epsilon subdivisions,2WPI1@28221|Deltaproteobacteria,2MRU7@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_38617_2 1121406.JAEX01000002_gene992 6.57e-18 77.8 COG2204@1|root,COG2204@2|Bacteria,1RJP7@1224|Proteobacteria,42SDG@68525|delta/epsilon subdivisions,2WP9A@28221|Deltaproteobacteria,2MC6P@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg k59_105379_1 1266925.JHVX01000020_gene1773 7.12e-19 93.6 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria,371P2@32003|Nitrosomonadales 28216|Betaproteobacteria J PFAM Aminoacyl-tRNA synthetase, class Ib trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_366578_1 1537917.JU82_00530 1.51e-26 100.0 COG0597@1|root,COG0597@2|Bacteria,1Q1GU@1224|Proteobacteria,42TMD@68525|delta/epsilon subdivisions,2YPZS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_366578_2 929558.SMGD1_1499 2.72e-100 308.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2YMDG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD k59_758066_1 1122978.AUFP01000001_gene1146 7.12e-07 49.7 COG0445@1|root,COG0445@2|Bacteria,4NFNH@976|Bacteroidetes,2FMA5@200643|Bacteroidia 976|Bacteroidetes D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_758066_2 1168034.FH5T_07810 2.16e-89 265.0 COG0503@1|root,COG0503@2|Bacteria,4NP7K@976|Bacteroidetes,2FPJ4@200643|Bacteroidia 976|Bacteroidetes F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_627919_2 273121.WS1110 2.61e-27 107.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,42NMD@68525|delta/epsilon subdivisions,2YR0T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_823988_1 765911.Thivi_1172 5.91e-67 220.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1WWXE@135613|Chromatiales 135613|Chromatiales S Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - DUF87 k59_267600_1 997296.PB1_12659 3.4e-40 144.0 COG0084@1|root,COG0084@2|Bacteria,1TQUP@1239|Firmicutes,4HBEN@91061|Bacilli,1ZCD5@1386|Bacillus 91061|Bacilli L TatD related DNase M1-591 - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_267600_2 536227.CcarbDRAFT_2325 3.22e-60 192.0 COG1670@1|root,COG1670@2|Bacteria,1V1ZC@1239|Firmicutes,249K2@186801|Clostridia,36ESI@31979|Clostridiaceae 186801|Clostridia J acetyltransferase - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_790563_1 266748.HY04_13215 1.23e-13 71.2 COG0038@1|root,COG0038@2|Bacteria,4NFCF@976|Bacteroidetes,1HWJE@117743|Flavobacteriia,3ZQX2@59732|Chryseobacterium 976|Bacteroidetes P Chloride channel protein - - - ko:K03281 - - - - ko00000 2.A.49 - - TrkA_C,Voltage_CLC k59_790563_2 563040.Saut_0196 1.86e-66 219.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2YN5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_888682_1 1337936.IJ00_27805 2.24e-65 213.0 COG3335@1|root,COG3335@2|Bacteria,1G4FA@1117|Cyanobacteria,1HQ3V@1161|Nostocales 1117|Cyanobacteria L Rhodopirellula transposase DDE domain - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_138108_1 1378168.N510_03092 6.65e-15 74.7 COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes 1239|Firmicutes M Membrane protein involved in D-alanine export algI - - - - - - - - - - - MBOAT k59_562873_1 697282.Mettu_2076 5.19e-78 240.0 COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales 135618|Methylococcales D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 k59_790564_1 526218.Sterm_1891 5.13e-06 54.7 COG3637@1|root,COG3637@2|Bacteria,37AE9@32066|Fusobacteria 32066|Fusobacteria M Psort location OuterMembrane, score - - - - - - - - - - - - OMP_b-brl k59_693181_1 1033810.HLPCO_000866 8.27e-152 437.0 COG1363@1|root,COG1363@2|Bacteria,2NQGB@2323|unclassified Bacteria 2|Bacteria G M42 glutamyl aminopeptidase frvX - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Peptidase_M42 k59_235597_1 1038867.AXAY01000002_gene3455 5.38e-39 136.0 COG1416@1|root,COG1416@2|Bacteria,1MZM7@1224|Proteobacteria,2UCT2@28211|Alphaproteobacteria,3JXSD@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_300374_1 1249480.B649_05085 8.46e-56 196.0 COG1344@1|root,COG1344@2|Bacteria,1N1QF@1224|Proteobacteria,42PDD@68525|delta/epsilon subdivisions,2YMYD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_202806_1 1232437.KL662073_gene1723 1.67e-83 261.0 COG2199@1|root,COG3706@2|Bacteria,1N9PI@1224|Proteobacteria,42MQF@68525|delta/epsilon subdivisions,2WIUE@28221|Deltaproteobacteria,2MJ68@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k59_758089_1 572544.Ilyop_0187 8.3e-95 293.0 COG0358@1|root,COG0358@2|Bacteria,3790T@32066|Fusobacteria 32066|Fusobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_N,zf-CHC2 k59_1020054_1 1168034.FH5T_08370 4.81e-69 218.0 COG0142@1|root,COG0142@2|Bacteria,4NET2@976|Bacteroidetes,2FMMI@200643|Bacteroidia 976|Bacteroidetes H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_1020054_2 1168034.FH5T_08365 2.2e-96 286.0 2BVTQ@1|root,2Z7J9@2|Bacteria,4NGSY@976|Bacteroidetes,2FWJ5@200643|Bacteroidia 976|Bacteroidetes S Protein of unknown function (DUF2797) - - - - - - - - - - - - DUF2797 k59_627952_1 1304883.KI912532_gene1273 4.02e-53 178.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,2KXXF@206389|Rhodocyclales 206389|Rhodocyclales C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_856756_1 929558.SMGD1_1652 7.14e-83 266.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2YNGB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member recD - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2,Viral_helicase1 k59_888708_2 1168034.FH5T_12840 2.71e-87 257.0 COG0091@1|root,COG0091@2|Bacteria,4NQ8E@976|Bacteroidetes,2FS3J@200643|Bacteroidia 976|Bacteroidetes J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_888708_3 1168034.FH5T_12845 1.45e-35 126.0 COG0092@1|root,COG0092@2|Bacteria,4NE9F@976|Bacteroidetes,2FMYX@200643|Bacteroidia 976|Bacteroidetes J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_334295_1 865861.AZSU01000001_gene354 2.57e-99 302.0 COG1012@1|root,COG1012@2|Bacteria,1UHQT@1239|Firmicutes,25E5E@186801|Clostridia,36H5G@31979|Clostridiaceae 186801|Clostridia C Aldehyde dehydrogenase family sucD - 1.2.1.76,1.2.1.81 ko:K15515,ko:K18119 ko00650,ko01100,ko01200,map00650,map01100,map01200 - R09280 RC00004,RC00184 ko00000,ko00001,ko01000 - - - Aldedh k59_334295_2 1196029.ALIM01000023_gene638 6.72e-19 88.6 29N94@1|root,3096Z@2|Bacteria,1V49G@1239|Firmicutes,4HHC5@91061|Bacilli,1ZH7E@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_334295_3 469618.FVAG_01147 1.39e-117 343.0 COG2357@1|root,COG2357@2|Bacteria,3794Q@32066|Fusobacteria 32066|Fusobacteria S Region found in RelA / SpoT proteins - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT k59_334295_4 1121423.JONT01000011_gene225 4.15e-25 110.0 COG0210@1|root,COG0210@2|Bacteria,1V0R3@1239|Firmicutes,24820@186801|Clostridia 186801|Clostridia L DNA helicase - - - - - - - - - - - - - k59_72325_2 469618.FVAG_01836 1.48e-150 444.0 COG0260@1|root,COG0260@2|Bacteria,378GS@32066|Fusobacteria 32066|Fusobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_790577_1 2340.JV46_28000 5.37e-47 159.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1J545@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_790577_2 2340.JV46_27980 3.24e-17 75.1 2EHQ5@1|root,33BFX@2|Bacteria,1NJW1@1224|Proteobacteria,1SHMS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Cbb3-type cytochrome oxidase component FixQ - - - - - - - - - - - - FixQ k59_987440_1 1168034.FH5T_09140 8.34e-22 93.2 COG3595@1|root,COG3595@2|Bacteria,4NIA2@976|Bacteroidetes 976|Bacteroidetes S Putative auto-transporter adhesin, head GIN domain - - - - - - - - - - - - DUF2807 k59_987440_2 1168034.FH5T_09135 6e-38 134.0 COG1983@1|root,COG1983@2|Bacteria,4PKK1@976|Bacteroidetes 976|Bacteroidetes KT Putative auto-transporter adhesin, head GIN domain - - - - - - - - - - - - DUF2807 k59_4371_1 1121481.AUAS01000008_gene2982 5.04e-25 104.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,4NGE5@976|Bacteroidetes,47M1I@768503|Cytophagia 976|Bacteroidetes K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 k59_4371_2 313594.PI23P_01607 1.26e-19 88.2 COG0038@1|root,COG0038@2|Bacteria,4NEIA@976|Bacteroidetes,1HYNQ@117743|Flavobacteriia,3VX6U@52959|Polaribacter 976|Bacteroidetes P Voltage gated chloride channel - - - - - - - - - - - - Voltage_CLC k59_856762_1 944547.ABLL_0328 2.85e-74 229.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,42M13@68525|delta/epsilon subdivisions,2YN50@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_987442_1 886377.Murru_3316 1.21e-55 186.0 COG0399@1|root,COG0399@2|Bacteria,4NG9W@976|Bacteroidetes,1HZDU@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.109 ko:K19715 - - R11395 RC00160 ko00000,ko01000,ko01005 - - - DegT_DnrJ_EryC1 k59_987442_2 1223410.KN050846_gene252 3.96e-28 110.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,4NF6I@976|Bacteroidetes,1HXKR@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_4374_1 1123368.AUIS01000005_gene383 2.07e-65 204.0 COG3255@1|root,COG3255@2|Bacteria,1N5G0@1224|Proteobacteria,1S8QU@1236|Gammaproteobacteria,2NCWZ@225057|Acidithiobacillales 225057|Acidithiobacillales I SCP-2 sterol transfer family - - - - - - - - - - - - SCP2 k59_202841_1 572544.Ilyop_0113 6.28e-119 350.0 COG1529@1|root,COG1529@2|Bacteria,379PW@32066|Fusobacteria 32066|Fusobacteria C PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding - - 1.17.1.5,1.2.99.7 ko:K07469,ko:K20447 ko00760,ko01120,map00760,map01120 - R01720 RC00589 ko00000,ko00001,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_242178_1 314287.GB2207_00750 2.17e-44 164.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1J59K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,VWA_2 k59_929541_1 1168034.FH5T_06770 4.4e-141 412.0 COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,2FMTR@200643|Bacteroidia 976|Bacteroidetes IQ Psort location Cytoplasmic, score 9.97 - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_635201_1 768671.ThimaDRAFT_3754 8.26e-245 677.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1WWV0@135613|Chromatiales 135613|Chromatiales E aminotransferase class I and II - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_635201_2 768671.ThimaDRAFT_3755 1.84e-185 526.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_44513_1 706587.Desti_5385 1.67e-58 202.0 COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_896348_1 1454004.AW11_03212 5.69e-105 318.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria,1KR2K@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P C-terminal region of aryl-sulfatase - - - - - - - - - - - - Sulfatase,Sulfatase_C k59_273580_1 391625.PPSIR1_37304 1.69e-111 342.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,42N0P@68525|delta/epsilon subdivisions,2WJCQ@28221|Deltaproteobacteria,2YU1P@29|Myxococcales 28221|Deltaproteobacteria C UPF0313 protein - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_341775_1 935863.AWZR01000013_gene1543 3.74e-109 325.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1X3B7@135614|Xanthomonadales 135614|Xanthomonadales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_306918_1 392499.Swit_2151 4.27e-14 75.1 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,2K18J@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_306918_2 1249480.B649_07905 2.31e-98 291.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2YTJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_405498_1 1123368.AUIS01000006_gene590 5.75e-60 191.0 2BKU0@1|root,32FA8@2|Bacteria,1RJX5@1224|Proteobacteria,1SJ45@1236|Gammaproteobacteria,2NCXG@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_602630_1 1298867.AUES01000051_gene4511 2.38e-26 112.0 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_242186_1 1123270.ATUR01000006_gene168 2.81e-09 67.8 COG1629@1|root,COG4771@2|Bacteria,1R3VE@1224|Proteobacteria,2UNZN@28211|Alphaproteobacteria,2KEC9@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_306923_1 643562.Daes_1119 1.91e-50 176.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,2M9JT@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_765111_1 1537917.JU82_08310 1.77e-81 249.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2YMXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins iscU - - ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N k59_177980_1 1408473.JHXO01000001_gene2411 8.93e-20 85.5 COG0811@1|root,COG0811@2|Bacteria,4NEA2@976|Bacteroidetes,2FMMQ@200643|Bacteroidia 976|Bacteroidetes U MotA TolQ ExbB proton channel family protein exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_177980_3 1168034.FH5T_05385 9.21e-56 178.0 COG0848@1|root,COG0848@2|Bacteria,4NHYQ@976|Bacteroidetes,2FMZ4@200643|Bacteroidia 976|Bacteroidetes U Biopolymer transport protein ExbD TolR - - - - - - - - - - - - ExbD k59_78944_2 1469245.JFBG01000016_gene965 4.32e-31 116.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X0T0@135613|Chromatiales 135613|Chromatiales O PFAM Cytochrome c oxidase assembly protein CtaG Cox11 - - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_145574_1 1168034.FH5T_09445 9.11e-105 308.0 COG1418@1|root,COG1418@2|Bacteria,4NEZY@976|Bacteroidetes,2FSKU@200643|Bacteroidia 976|Bacteroidetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06950 - - - - ko00000 - - - HD k59_668327_1 1408439.JHXW01000003_gene1545 5.88e-118 352.0 COG2252@1|root,COG2252@2|Bacteria,37914@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k59_765128_1 1168034.FH5T_12720 9.11e-63 207.0 COG0155@1|root,COG0155@2|Bacteria,4NENW@976|Bacteroidetes,2FRKX@200643|Bacteroidia 976|Bacteroidetes P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate cysI - 1.7.7.1,1.8.1.2 ko:K00366,ko:K00381 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00858 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_765128_2 1168034.FH5T_12715 3.62e-33 126.0 COG0369@1|root,COG0369@2|Bacteria,4NHR8@976|Bacteroidetes,2FR5G@200643|Bacteroidia 976|Bacteroidetes P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component cysJ - 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_1,Flavodoxin_1,NAD_binding_1 k59_537550_1 1122169.AREN01000052_gene227 7.51e-42 158.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1JFDY@118969|Legionellales 118969|Legionellales Q COG2931 RTX toxins and related Ca2 -binding proteins rtxA2_1 - - - - - - - - - - - Cadherin_3,HemolysinCabind k59_505327_2 765912.Thimo_1066 1.13e-34 127.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1WW81@135613|Chromatiales 135613|Chromatiales E TIGRFAM Serine O-acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_306944_3 1123253.AUBD01000005_gene86 4.74e-32 122.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1X3RE@135614|Xanthomonadales 135614|Xanthomonadales S Rossmann fold nucleotide-binding protein - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_765134_1 140110.NechaP101296 1.1e-15 77.0 COG5265@1|root,KOG0056@2759|Eukaryota,38D03@33154|Opisthokonta,3NV8N@4751|Fungi,3QJEX@4890|Ascomycota,211E9@147550|Sordariomycetes,3TDPW@5125|Hypocreales,1FSP8@110618|Nectriaceae 4751|Fungi Q ABC transporter transmembrane region hmt1 GO:0000041,GO:0000166,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006857,GO:0006950,GO:0007034,GO:0008144,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0015399,GO:0015405,GO:0015440,GO:0015711,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030001,GO:0030554,GO:0031090,GO:0031166,GO:0031224,GO:0031300,GO:0031301,GO:0031310,GO:0032553,GO:0032555,GO:0032559,GO:0033220,GO:0034220,GO:0034486,GO:0034635,GO:0034775,GO:0035443,GO:0035639,GO:0035672,GO:0036094,GO:0036246,GO:0036249,GO:0042221,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0042939,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044604,GO:0046686,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0051716,GO:0055085,GO:0061687,GO:0070887,GO:0071241,GO:0071248,GO:0071276,GO:0071585,GO:0071627,GO:0071628,GO:0071702,GO:0071705,GO:0071993,GO:0071994,GO:0071995,GO:0071996,GO:0072337,GO:0072348,GO:0097159,GO:0097237,GO:0097367,GO:0097501,GO:0098588,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:0098754,GO:0098805,GO:0098849,GO:0098852,GO:1901265,GO:1901363,GO:1904680,GO:1990170,GO:1990748 - ko:K05661 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.210 - - ABC_membrane,ABC_tran k59_765134_2 977880.RALTA_A0814 3.91e-16 84.0 COG3306@1|root,COG3306@2|Bacteria,1N6W4@1224|Proteobacteria,2VVKA@28216|Betaproteobacteria,1K896@119060|Burkholderiaceae 28216|Betaproteobacteria M Glycosyltransferase family 25 (LPS biosynthesis protein) - - - ko:K07270 - - - - ko00000 - GT25 - Glyco_transf_25 k59_668352_1 709032.Sulku_0395 2.1e-108 327.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2YMB5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S abc transporter atp-binding protein yheS - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_537564_1 1123057.P872_04760 2.74e-36 142.0 COG3291@1|root,COG5498@1|root,COG3291@2|Bacteria,COG5498@2|Bacteria,4PPR2@976|Bacteroidetes,47YQN@768503|Cytophagia 976|Bacteroidetes G Pkd domain containing protein - - - - - - - - - - - - - k59_505345_1 1537917.JU82_06155 5.91e-110 328.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YMN1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_896410_1 749222.Nitsa_0379 5.37e-124 360.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2YNCB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0330 IlvC,IlvN k59_569610_1 224911.27353747 2.48e-23 105.0 COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U1YP@28211|Alphaproteobacteria,3JRUE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - VWA,VWA_2 k59_929605_1 1168034.FH5T_05450 3.1e-30 111.0 2CADI@1|root,32RR7@2|Bacteria,4NP51@976|Bacteroidetes,2FSVU@200643|Bacteroidia 976|Bacteroidetes S COG NOG14471 non supervised orthologous group lptE - - - - - - - - - - - LptE k59_929605_2 1168034.FH5T_05445 6.5e-36 130.0 28HHN@1|root,2Z7TA@2|Bacteria,4NEXR@976|Bacteroidetes,2FQ6G@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_668357_1 1297742.A176_01648 5.79e-10 55.8 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,42SEH@68525|delta/epsilon subdivisions,2WQWW@28221|Deltaproteobacteria,2YW79@29|Myxococcales 28221|Deltaproteobacteria FG HIT domain hinT - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_668357_2 948565.AFFP02000001_gene889 2.89e-40 144.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1Y7MZ@135625|Pasteurellales 135625|Pasteurellales S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_242228_1 765912.Thimo_0736 3.1e-63 196.0 COG0432@1|root,COG0432@2|Bacteria,1RIKJ@1224|Proteobacteria,1S8QM@1236|Gammaproteobacteria,1WYII@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_537570_1 266264.Rmet_1732 1.27e-17 89.7 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2VTT4@28216|Betaproteobacteria 28216|Betaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_44565_1 693272.E3T5N3_CROVB 1.39e-53 193.0 4QBH7@10239|Viruses,4QWWF@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA ligase (NAD+) activity - - - - - - - - - - - - - k59_306964_2 314282.PCNPT3_10670 1.67e-33 130.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406,ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_306964_3 387093.SUN_0508 3.11e-153 433.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M6H@68525|delta/epsilon subdivisions,2YNC6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S ferredoxin - - - - - - - - - - - - Fer4_11,Fer4_4 k59_306964_4 387093.SUN_0509 1.28e-63 204.0 COG3301@1|root,COG3301@2|Bacteria,1QSRQ@1224|Proteobacteria,42PAY@68525|delta/epsilon subdivisions,2YN5Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_537572_1 1298858.AUEL01000002_gene1796 5.82e-18 80.9 COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria,43PTH@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Cupredoxin-like domain - - - - - - - - - - - - Copper-bind,Cupredoxin_1 k59_731697_1 1168034.FH5T_08815 4.64e-82 271.0 COG1729@1|root,COG1729@2|Bacteria,4PKGA@976|Bacteroidetes,2G3G6@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 k59_470790_1 521719.ATXQ01000001_gene617 9.28e-111 326.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1YEMW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Branched-chain amino acid ATP-binding cassette transporter lptB GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_470790_2 323261.Noc_2793 8.94e-11 61.6 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1WVZD@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_178040_1 472759.Nhal_2509 2.51e-123 372.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1WW8N@135613|Chromatiales 135613|Chromatiales I Acetoacetyl-CoA synthase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_994757_2 435838.HMPREF0786_02159 4.93e-09 58.9 COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,4HB7Q@91061|Bacilli,4GXR5@90964|Staphylococcaceae 91061|Bacilli K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N k59_306976_1 1168034.FH5T_04080 2.23e-160 481.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FM37@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_700050_1 1123073.KB899241_gene3167 2.35e-47 173.0 28MY3@1|root,2ZB50@2|Bacteria,1R833@1224|Proteobacteria,1RY08@1236|Gammaproteobacteria,1XB4R@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_765172_1 1095747.HMPREF1049_0692 2.69e-23 94.4 COG0781@1|root,COG0781@2|Bacteria,37AMY@32066|Fusobacteria 32066|Fusobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_765172_2 1148.1001298 0.000568 50.4 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1G0VR@1117|Cyanobacteria,1H4YE@1142|Synechocystis 1117|Cyanobacteria T Signal transducing histidine kinase, homodimeric domain - - - ko:K11526 ko02020,map02020 M00508 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_668386_1 1208323.B30_01255 4.09e-07 59.3 COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - ko:K07004 - - - - ko00000 - - - Calx-beta,DUF4347,HemolysinCabind,PPC,P_proprotein,Peptidase_M10,Peptidase_M10_C,Peptidase_S8 k59_765175_2 864702.OsccyDRAFT_3492 0.000214 45.8 COG5607@1|root,COG5607@2|Bacteria,1G1T8@1117|Cyanobacteria,1H9I0@1150|Oscillatoriales 1117|Cyanobacteria S PFAM CHAD domain - - - - - - - - - - - - CHAD k59_273649_1 864073.HFRIS_012929 3.22e-78 239.0 COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2VKEU@28216|Betaproteobacteria,47459@75682|Oxalobacteraceae 28216|Betaproteobacteria O maleylacetoacetate isomerase maiA - 5.2.1.2,5.2.1.4 ko:K01800,ko:K01801 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R03181,R03868 RC00867 ko00000,ko00001,ko00002,ko01000 - - - GST_C_2,GST_C_3,GST_N,GST_N_3 k59_210521_1 1121875.KB907546_gene2199 9.1e-102 310.0 COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1I2RR@117743|Flavobacteriia 976|Bacteroidetes Q PFAM D-aminoacylase, C-terminal region - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_8707_1 519989.ECTPHS_12803 3.66e-171 486.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WWFM@135613|Chromatiales 135613|Chromatiales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1026304_1 1168034.FH5T_05725 1.82e-145 422.0 COG0591@1|root,COG0591@2|Bacteria,4NEF3@976|Bacteroidetes,2FM9G@200643|Bacteroidia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_602719_1 1236541.BALL01000042_gene3921 1.4e-70 230.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,1SYM5@1236|Gammaproteobacteria,2Q8MR@267890|Shewanellaceae 1236|Gammaproteobacteria C fumarate reductase succinate dehydrogenase flavoprotein domain protein - - - - - - - - - - - - FAD_binding_2 k59_765184_1 1537917.JU82_02410 1.4e-65 213.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2YMAG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_961521_1 593907.Celgi_0559 1.27e-61 214.0 COG1112@1|root,COG1112@2|Bacteria,2GKJW@201174|Actinobacteria,4F0UY@85016|Cellulomonadaceae 201174|Actinobacteria L Superfamily I DNA and RNA helicases and helicase subunits - - - - - - - - - - - - AAA_11,AAA_12,DUF4011 k59_471387_2 469618.FVAG_02886 1.14e-59 199.0 COG0771@1|root,COG0771@2|Bacteria,378DR@32066|Fusobacteria 32066|Fusobacteria D Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_863542_1 983548.Krodi_2041 1.58e-105 310.0 COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,1HXPP@117743|Flavobacteriia,37EI5@326319|Dokdonia 976|Bacteroidetes V ATPases associated with a variety of cellular activities macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_995402_1 1123257.AUFV01000006_gene375 1.02e-69 219.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,1X4J6@135614|Xanthomonadales 135614|Xanthomonadales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_962154_2 1150621.SMUL_1545 2.2e-61 195.0 COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,42TMF@68525|delta/epsilon subdivisions 1224|Proteobacteria H Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate cobU GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008819,GO:0008820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0033554,GO:0044237,GO:0050896,GO:0051716,GO:0070568 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_2074,iECSE_1348.ECSE_2277,iECW_1372.ECW_m2165,iETEC_1333.ETEC_2103,iEcE24377_1341.EcE24377A_2275,iEcSMS35_1347.EcSMS35_1131,iEcolC_1368.EcolC_1635,iLF82_1304.LF82_0337,iSDY_1059.SDY_2240,iWFL_1372.ECW_m2165 CobU k59_635944_2 1172190.M947_07815 6.15e-69 213.0 COG0716@1|root,COG0716@2|Bacteria,1MX7F@1224|Proteobacteria,42Q5G@68525|delta/epsilon subdivisions,2YPA9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Low-potential electron donor to a number of redox enzymes fldA - - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 k59_438371_1 1249627.D779_3825 3.87e-94 296.0 COG0480@1|root,COG0480@2|Bacteria,1PMU3@1224|Proteobacteria,1S00P@1236|Gammaproteobacteria,1WXBY@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_307713_1 880073.Calab_3187 2.69e-09 62.4 COG4591@1|root,COG4591@2|Bacteria,2NQKW@2323|unclassified Bacteria 2|Bacteria M MacB-like periplasmic core domain VPA0558 - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_930279_1 555500.I215_12463 6.54e-85 262.0 COG0381@1|root,COG0381@2|Bacteria,4NGBD@976|Bacteroidetes,1HXDA@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_274198_1 572544.Ilyop_0241 6.15e-194 567.0 COG0653@1|root,COG0653@2|Bacteria,378NS@32066|Fusobacteria 32066|Fusobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_274198_2 469617.FUAG_00142 3.46e-10 62.4 2CDFI@1|root,2ZANH@2|Bacteria,379UQ@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_506116_1 257310.BB0876 3.69e-111 332.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2VJ7A@28216|Betaproteobacteria,3T1BK@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wbpO - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_603431_1 568706.BN118_0539 7.36e-189 565.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,3T2UZ@506|Alcaligenaceae 28216|Betaproteobacteria C FAD linked oxidase, C-terminal domain-containing protein 6 glpCD - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_112432_1 572544.Ilyop_0620 4.53e-110 324.0 COG0191@1|root,COG0191@2|Bacteria,378U7@32066|Fusobacteria 32066|Fusobacteria G Fructose-1,6-bisphosphate aldolase, class II fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_79498_1 749222.Nitsa_0571 9.3e-123 358.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2YMA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM k59_79498_2 1172190.M947_10425 7.01e-180 506.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions 1224|Proteobacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_700731_1 377629.TERTU_0977 7.41e-63 205.0 COG3007@1|root,COG3007@2|Bacteria,1MWCQ@1224|Proteobacteria,1RPPP@1236|Gammaproteobacteria,2PMTA@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria I NAD(P)H binding domain of trans-2-enoyl-CoA reductase fabV GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.44,1.3.1.9 ko:K00209 ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212 M00083 R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase k59_378167_1 1166948.JPZL01000002_gene1648 1.05e-23 95.1 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1XJ7F@135619|Oceanospirillales 135619|Oceanospirillales L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_378167_2 1123399.AQVE01000001_gene559 4.62e-14 73.2 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,45ZWZ@72273|Thiotrichales 72273|Thiotrichales O PFAM Peptidase family M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_574678_1 1249627.D779_3549 9.39e-116 335.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1WW34@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_574678_2 1249627.D779_3550 1.01e-75 227.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1WYDZ@135613|Chromatiales 135613|Chromatiales J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_574678_3 2340.JV46_07160 1.18e-62 193.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1J67P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_673367_1 1347086.CCBA010000009_gene1342 3.7e-134 398.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,1ZFH2@1386|Bacillus 91061|Bacilli G Belongs to the glycosyl hydrolase 3 family XK27_03135 - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_574679_1 1123400.KB904817_gene1524 2.13e-86 274.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,45ZPN@72273|Thiotrichales 72273|Thiotrichales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_574680_1 1209072.ALBT01000066_gene1118 6.99e-08 61.2 COG0745@1|root,COG2199@1|root,COG4251@1|root,COG5278@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,1R7HC@1224|Proteobacteria,1T2D4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T response regulator - - - - - - - - - - - - CHASE3,GAF_2,GGDEF,HATPase_c,HisKA,Response_reg k59_574680_2 435832.HMPREF0604_00726 3.55e-18 82.8 COG0484@1|root,COG3671@1|root,COG0484@2|Bacteria,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria,2KU3P@206351|Neisseriales 206351|Neisseriales O membrane - - - - - - - - - - - - DnaJ k59_442623_1 869213.JCM21142_104556 5.59e-41 147.0 COG0668@1|root,COG0668@2|Bacteria,4NH7C@976|Bacteroidetes 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_378194_1 367737.Abu_1127 1.37e-61 203.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2YN0D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J MiaB-like tRNA modifying enzyme yqeV - - - - - - - - - - - Radical_SAM,UPF0004 k59_999758_1 1168034.FH5T_14930 1.58e-160 456.0 COG0668@1|root,COG0668@2|Bacteria,4NFHD@976|Bacteroidetes,2FX9X@200643|Bacteroidia 976|Bacteroidetes M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_215641_2 1047013.AQSP01000124_gene2679 8.35e-22 94.7 COG3166@1|root,COG3166@2|Bacteria,2NRP1@2323|unclassified Bacteria 2|Bacteria NU Fimbrial assembly protein (PilN) pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_346925_1 1249627.D779_4113 4.77e-102 331.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_934361_1 96561.Dole_2060 7.87e-86 264.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WKNZ@28221|Deltaproteobacteria,2MIYZ@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_934362_1 326298.Suden_1892 6.2e-101 313.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,43BJ8@68525|delta/epsilon subdivisions,2YMMJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M penicillin-binding protein pbpA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_378209_1 1168034.FH5T_07055 1.41e-15 72.0 COG0802@1|root,COG0802@2|Bacteria,4NS89@976|Bacteroidetes,2FS1V@200643|Bacteroidia 976|Bacteroidetes S Hydrolase, P-loop family yjeE - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_378209_2 1168034.FH5T_07050 5.64e-58 181.0 COG0509@1|root,COG0509@2|Bacteria,4NQ35@976|Bacteroidetes,2FT3J@200643|Bacteroidia 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_83795_2 1304284.L21TH_0373 1.48e-31 122.0 COG4670@1|root,COG4670@2|Bacteria,1TP5H@1239|Firmicutes,247ZG@186801|Clostridia,36DYM@31979|Clostridiaceae 186801|Clostridia I Belongs to the 3-oxoacid CoA-transferase family - - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_83797_1 1101195.Meth11DRAFT_2196 3.46e-18 82.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2VNAX@28216|Betaproteobacteria,2KKR3@206350|Nitrosomonadales 206350|Nitrosomonadales I Phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_83797_2 314275.MADE_1000025 3.61e-50 177.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,464Q3@72275|Alteromonadaceae 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_183144_1 1168034.FH5T_18290 3.42e-138 400.0 COG3875@1|root,COG3875@2|Bacteria,4NI4Z@976|Bacteroidetes,2FQM8@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 k59_278491_1 1168034.FH5T_18385 2.83e-240 666.0 COG0621@1|root,COG0621@2|Bacteria,4NEJK@976|Bacteroidetes,2FMEW@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_673390_1 399741.Spro_1174 7.74e-11 67.0 COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,1S8Q2@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q DSBA oxidoreductase frnE - - - - - - - - - - - DSBA k59_705172_1 1178825.ALIH01000010_gene400 5.06e-08 59.3 COG3291@1|root,COG3291@2|Bacteria,4PKMZ@976|Bacteroidetes,1I01F@117743|Flavobacteriia 976|Bacteroidetes O TIGRFAM Por secretion system C-terminal sorting domain - - - - - - - - - - - - CHU_C k59_867902_1 2340.JV46_06120 1.06e-81 250.0 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,1J5MC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative neutral zinc metallopeptidase ypfJ - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_410602_1 1449050.JNLE01000003_gene3300 5.33e-27 114.0 COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,248E0@186801|Clostridia,36DXQ@31979|Clostridiaceae 186801|Clostridia G Glucose sorbosone - - - - - - - - - - - - GSDH k59_799715_1 177437.HRM2_46600 5.58e-65 213.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,42NNJ@68525|delta/epsilon subdivisions,2WKP9@28221|Deltaproteobacteria,2MKV7@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,DUF2924,Transposase_20 k59_378223_1 1304872.JAGC01000003_gene2753 3.54e-40 152.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - DUF4118,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg k59_770370_2 1123367.C666_05015 2.38e-45 160.0 2DBUZ@1|root,2ZB8W@2|Bacteria,1QWGF@1224|Proteobacteria,2VM8U@28216|Betaproteobacteria,2KVDM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_475813_1 247639.MGP2080_05997 1.37e-114 342.0 COG0446@1|root,COG0446@2|Bacteria,1Q0P8@1224|Proteobacteria,1T1NQ@1236|Gammaproteobacteria,1J7YY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_608359_2 1121423.JONT01000016_gene1181 3.94e-24 110.0 COG3451@1|root,COG3451@2|Bacteria,1TPDR@1239|Firmicutes,248ND@186801|Clostridia 186801|Clostridia U Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_10,CagE_TrbE_VirB,DUF87 k59_640958_1 446466.Cfla_0006 9.5e-112 341.0 COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4F0P7@85016|Cellulomonadaceae 201174|Actinobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_640960_1 1255043.TVNIR_0497 8.5e-30 122.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales 135613|Chromatiales M Surface antigen variable number - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_216399_1 395493.BegalDRAFT_3320 7.94e-73 233.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,46093@72273|Thiotrichales 72273|Thiotrichales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_476517_1 95619.PM1_0202270 1.22e-107 326.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2699 PALP,Thr_dehydrat_C k59_511109_1 204669.Acid345_2436 9.47e-17 79.0 28IJB@1|root,2Z8K8@2|Bacteria,3Y62T@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - k59_511109_2 392499.Swit_4409 1.85e-26 108.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TRQ5@28211|Alphaproteobacteria,2K0GN@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the peptidase M24B family - - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_608373_1 1500893.JQNB01000001_gene1558 2.52e-81 261.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1X498@135614|Xanthomonadales 135614|Xanthomonadales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_836411_1 1165841.SULAR_10619 4.07e-126 372.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2YMSH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c oxidase accessory protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_836411_2 387093.SUN_0071 4.88e-16 76.3 COG1961@1|root,COG1961@2|Bacteria,1Q5XK@1224|Proteobacteria,42TRW@68525|delta/epsilon subdivisions,2YQ0Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L PFAM Resolvase, N terminal domain - - - - - - - - - - - - HTH_7,Resolvase k59_443398_1 396588.Tgr7_1533 1.84e-123 360.0 COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,1T1SF@1236|Gammaproteobacteria,1WY8X@135613|Chromatiales 135613|Chromatiales M mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_443398_2 95619.PM1_0208150 1.87e-21 95.1 COG2885@1|root,COG2885@2|Bacteria,1RENP@1224|Proteobacteria,1S4IW@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family oprF - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 k59_443398_3 748658.KB907317_gene274 3.7e-23 98.2 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria,1WWQU@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_967371_1 572544.Ilyop_0792 4.06e-78 246.0 COG0477@1|root,COG2814@2|Bacteria,37BEP@32066|Fusobacteria 32066|Fusobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_312628_1 525309.HMPREF0494_1029 9.41e-50 178.0 COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,4HB81@91061|Bacilli,3F3XM@33958|Lactobacillaceae 91061|Bacilli L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_868652_1 572544.Ilyop_0494 1.28e-104 330.0 COG0741@1|root,COG1729@1|root,COG0741@2|Bacteria,COG1729@2|Bacteria,379K5@32066|Fusobacteria 32066|Fusobacteria M Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,TPR_6 k59_248026_1 472759.Nhal_0758 4.36e-118 362.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_14181_1 247633.GP2143_14561 5.9e-52 178.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_543027_1 709032.Sulku_1933 2.87e-102 308.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,42MVB@68525|delta/epsilon subdivisions,2YNU4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E O-acetylhomoserine sulfhydrylase - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_50125_1 1266914.ATUK01000016_gene447 2.9e-36 135.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1S1NC@1236|Gammaproteobacteria,1X06R@135613|Chromatiales 135613|Chromatiales T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_50125_2 85643.Tmz1t_0383 5.24e-30 119.0 COG4191@1|root,COG4191@2|Bacteria,1QVHZ@1224|Proteobacteria,2VJ34@28216|Betaproteobacteria,2KVSJ@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_705931_1 762968.HMPREF9441_01870 2.23e-57 202.0 COG4625@1|root,COG5492@1|root,COG4625@2|Bacteria,COG5492@2|Bacteria,4P0ZG@976|Bacteroidetes,2FW5M@200643|Bacteroidia 976|Bacteroidetes N FG-GAP repeat protein - - - - - - - - - - - - PATR k59_151252_1 1168034.FH5T_07710 3.28e-195 554.0 COG0446@1|root,COG0446@2|Bacteria,4NE3A@976|Bacteroidetes,2FKYC@200643|Bacteroidia 976|Bacteroidetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_575407_2 535289.Dtpsy_2595 1.57e-27 108.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,2VRHV@28216|Betaproteobacteria,4AEAE@80864|Comamonadaceae 28216|Betaproteobacteria S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_312644_1 314285.KT71_05607 1.14e-126 373.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,1S7XK@1236|Gammaproteobacteria,1JC1M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_14196_1 933262.AXAM01000067_gene855 3.49e-43 159.0 2A7N3@1|root,30WK3@2|Bacteria,1NERD@1224|Proteobacteria,42P7M@68525|delta/epsilon subdivisions,2WJTH@28221|Deltaproteobacteria,2MIHK@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_640985_1 1168034.FH5T_06235 5.68e-79 245.0 COG3386@1|root,COG3386@2|Bacteria,4PKGZ@976|Bacteroidetes 976|Bacteroidetes G phospholipase Carboxylesterase - - - - - - - - - - - - - k59_117666_1 1461577.CCMH01000040_gene219 4.04e-51 181.0 COG3741@1|root,COG3930@1|root,COG3741@2|Bacteria,COG3930@2|Bacteria,4NG5D@976|Bacteroidetes,1HZIT@117743|Flavobacteriia 976|Bacteroidetes E protein conserved in bacteria - - - - - - - - - - - - DUF1704,FGase k59_511115_1 1485545.JQLW01000006_gene397 3.37e-17 81.3 COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria 1224|Proteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_511115_2 95619.PM1_0202845 1.97e-102 301.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186 Pribosyltran k59_511115_3 768671.ThimaDRAFT_0532 2.65e-36 125.0 2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,1SGKD@1236|Gammaproteobacteria,1WYKI@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 k59_511115_4 1002339.HMPREF9373_1458 2.25e-65 205.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria,3NK46@468|Moraxellaceae 1236|Gammaproteobacteria S Appr-1'-p processing enzyme ymdB GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231 - - - - - - - - - - Macro k59_511115_5 572477.Alvin_2731 4.95e-125 363.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,1WW8S@135613|Chromatiales 135613|Chromatiales S PFAM conserved - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_511115_6 1121939.L861_10585 4.03e-55 181.0 COG1136@1|root,COG1136@2|Bacteria,1RH0D@1224|Proteobacteria,1T21A@1236|Gammaproteobacteria,1XPRX@135619|Oceanospirillales 135619|Oceanospirillales V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran k59_511115_7 1122134.KB893650_gene195 1.66e-84 258.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1XH39@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_511115_8 1249627.D779_0834 4e-155 439.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1WW65@135613|Chromatiales 135613|Chromatiales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_511115_9 290398.Csal_3147 1.51e-21 85.9 COG2104@1|root,COG2104@2|Bacteria,1N8P3@1224|Proteobacteria,1SCZM@1236|Gammaproteobacteria 1236|Gammaproteobacteria H COG2104 Sulfur transfer protein involved in thiamine biosynthesis thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_511115_10 1049564.TevJSym_bv00090 2.44e-168 507.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1J6SC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M involved in outer membrane biogenesis asmA - - ko:K07289 - - - - ko00000 - - - AsmA k59_511115_11 349124.Hhal_1142 4.42e-40 134.0 COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1WYU9@135613|Chromatiales 135613|Chromatiales CO Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic k59_511115_12 1123511.KB905849_gene3296 0.000257 39.7 2EHF3@1|root,33B70@2|Bacteria,1VP4D@1239|Firmicutes,4H6DK@909932|Negativicutes 909932|Negativicutes - - - - - - - - - - - - - - - k59_216428_1 1249480.B649_03720 8e-25 104.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,42T05@68525|delta/epsilon subdivisions 1224|Proteobacteria S Protein kinase, ABC1 domain-containing - - - - - - - - - - - - ABC1,APH k59_216428_2 1123359.AUIQ01000038_gene323 1.24e-22 94.7 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,4HA37@91061|Bacilli,4AZI7@81852|Enterococcaceae 91061|Bacilli I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_476546_1 1165841.SULAR_06378 3.09e-63 202.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,42M6U@68525|delta/epsilon subdivisions,2YN4H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - 1.21.98.1 ko:K11784 ko00130,ko01110,map00130,map01110 - R08588 RC02329 ko00000,ko00001,ko01000 - - - Radical_SAM k59_476546_2 387093.SUN_1916 6.49e-19 85.1 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2YMI1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Peptidase, M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_379014_1 4081.Solyc00g052430.2.1 1.72e-101 303.0 COG2801@1|root,KOG0017@2759|Eukaryota,37TAQ@33090|Viridiplantae,3GDDG@35493|Streptophyta 35493|Streptophyta L cellular component organization ccmFc GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464 - - - - - - - - - - CcmF_C k59_967401_1 457405.FSDG_01052 4.1e-74 230.0 COG0682@1|root,COG0682@2|Bacteria,37843@32066|Fusobacteria 32066|Fusobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_967401_2 572544.Ilyop_1168 1.19e-194 550.0 COG0426@1|root,COG0426@2|Bacteria,378GG@32066|Fusobacteria 32066|Fusobacteria C Metallo-beta-lactamase superfamily - - - - - - - - - - - - Flavodoxin_1,Lactamase_B k59_967401_3 469618.FVAG_00713 5.1e-57 186.0 COG2095@1|root,COG2095@2|Bacteria,37AC2@32066|Fusobacteria 32066|Fusobacteria U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_967401_4 658655.HMPREF0988_01829 3.2e-60 192.0 COG0693@1|root,COG0693@2|Bacteria,1V3WB@1239|Firmicutes,24HGU@186801|Clostridia,27MFN@186928|unclassified Lachnospiraceae 186801|Clostridia S DJ-1/PfpI family yajL - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_967401_5 1499689.CCNN01000007_gene2108 3.49e-78 238.0 COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,36EH9@31979|Clostridiaceae 186801|Clostridia E Serine acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_967401_6 572544.Ilyop_0108 1.17e-107 331.0 COG0714@1|root,COG0714@2|Bacteria,37A73@32066|Fusobacteria 32066|Fusobacteria S AAA domain (dynein-related subfamily) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_5 k59_699358_1 471854.Dfer_2150 3.73e-89 289.0 COG5434@1|root,COG5434@2|Bacteria,4NE4H@976|Bacteroidetes,47NFA@768503|Cytophagia 976|Bacteroidetes M Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - - k59_341141_1 126957.SMAR009749-PA 1.03e-13 79.3 COG0553@1|root,KOG0385@2759|Eukaryota,38CTE@33154|Opisthokonta,3B9KK@33208|Metazoa,3CVBA@33213|Bilateria,41VZ1@6656|Arthropoda 33208|Metazoa K SNF2 family N-terminal domain HELLS GO:0000775,GO:0000785,GO:0000792,GO:0001655,GO:0001775,GO:0002376,GO:0002520,GO:0002521,GO:0003674,GO:0003682,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005721,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006323,GO:0006325,GO:0006333,GO:0006338,GO:0006342,GO:0006346,GO:0006355,GO:0006725,GO:0006807,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0008283,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010216,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010648,GO:0010941,GO:0016043,GO:0016458,GO:0016569,GO:0019219,GO:0019222,GO:0022607,GO:0023051,GO:0023057,GO:0030097,GO:0030098,GO:0030154,GO:0031055,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031497,GO:0031507,GO:0031508,GO:0032259,GO:0032501,GO:0032502,GO:0032943,GO:0034097,GO:0034508,GO:0034622,GO:0034641,GO:0040029,GO:0042221,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0044728,GO:0045321,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046649,GO:0046651,GO:0048513,GO:0048519,GO:0048523,GO:0048534,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051276,GO:0051716,GO:0060255,GO:0060548,GO:0065003,GO:0065004,GO:0065007,GO:0070661,GO:0070828,GO:0070887,GO:0071103,GO:0071310,GO:0071345,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0098687,GO:1901360,GO:1902531,GO:1902532,GO:1902679,GO:1903506,GO:1903507,GO:1990823,GO:1990830,GO:2000112,GO:2000113,GO:2001141,GO:2001233,GO:2001234,GO:2001242,GO:2001243 - ko:K19001 - - - - ko00000,ko03036 - - - Helicase_C,SNF2_N k59_830047_1 1547445.LO80_04355 2.28e-19 83.2 COG3153@1|root,COG3153@2|Bacteria,1QU4W@1224|Proteobacteria 1224|Proteobacteria S acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_764421_1 1209072.ALBT01000012_gene3344 1.21e-59 193.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RY7P@1236|Gammaproteobacteria,1FG0N@10|Cellvibrio 1236|Gammaproteobacteria J RNA 2'-O ribose methyltransferase substrate binding - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_504578_1 1279017.AQYJ01000019_gene1472 5.72e-42 146.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,464HA@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_504578_2 1121878.AUGL01000033_gene2046 6.83e-63 195.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Ribosomal protein L17 rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_241572_1 1123326.JFBL01000001_gene1265 4.8e-102 306.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YNBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_437062_1 1249480.B649_03675 3.65e-29 120.0 COG2319@1|root,COG2319@2|Bacteria,1Q4KY@1224|Proteobacteria,42ZEF@68525|delta/epsilon subdivisions,2YR4A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S WD40 repeats - - - - - - - - - - - - - k59_634622_1 765910.MARPU_00320 3.61e-107 317.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1WWD5@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase S33 family - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_404900_1 331678.Cphamn1_2123 2.73e-41 155.0 COG1067@1|root,COG1067@2|Bacteria,1FETE@1090|Chlorobi 1090|Chlorobi O PFAM peptidase S16 lon domain protein - - - - - - - - - - - - AAA_32,Lon_C k59_699367_1 1172190.M947_00600 1.15e-36 128.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2YPEC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_699367_2 709032.Sulku_1431 8.11e-94 277.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2YN3P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Imidazoleglycerol-phosphate dehydratase hisB - 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD,PNK3P k59_306324_1 749222.Nitsa_1666 6.81e-21 90.1 COG0745@1|root,COG0745@2|Bacteria,1QZMS@1224|Proteobacteria,43CKH@68525|delta/epsilon subdivisions,2YTDI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_536875_1 765911.Thivi_4300 5.75e-78 254.0 COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,1SBWP@1236|Gammaproteobacteria,1WZ1F@135613|Chromatiales 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_862210_1 1121405.dsmv_3461 3.19e-132 385.0 COG0232@1|root,COG0232@2|Bacteria,1R6QQ@1224|Proteobacteria,42M0H@68525|delta/epsilon subdivisions,2WJ33@28221|Deltaproteobacteria,2MHN1@213118|Desulfobacterales 28221|Deltaproteobacteria F SMART metal-dependent phosphohydrolase HD region - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_699370_1 1278073.MYSTI_03686 2.75e-07 58.9 COG2356@1|root,COG4935@1|root,COG2356@2|Bacteria,COG4935@2|Bacteria,1MXQM@1224|Proteobacteria,42P2N@68525|delta/epsilon subdivisions,2WT6E@28221|Deltaproteobacteria,2YV8G@29|Myxococcales 28221|Deltaproteobacteria L Endonuclease I - - - - - - - - - - - - Endonuclease_1,P_proprotein k59_994101_1 1151292.QEW_3853 4.63e-101 306.0 COG0477@1|root,COG2814@2|Bacteria,1TQXU@1239|Firmicutes,24MJI@186801|Clostridia 186801|Clostridia EGP Psort location CytoplasmicMembrane, score 10.00 - - - ko:K08159,ko:K08164 - - - - ko00000,ko02000 2.A.1.2,2.A.1.2.15,2.A.1.2.18 - - MFS_1,Sugar_tr k59_994101_2 553973.CLOHYLEM_07388 3.26e-19 84.7 COG0583@1|root,COG0583@2|Bacteria,1TP77@1239|Firmicutes,248CX@186801|Clostridia,21ZJ9@1506553|Lachnoclostridium 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate k59_731088_1 709032.Sulku_1494 1.06e-17 90.9 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YMHP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3 k59_667644_1 326298.Suden_1616 4.91e-37 138.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2YMA5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_895663_1 1121405.dsmv_2732 9.1e-12 71.6 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_306339_1 1149133.ppKF707_1285 3.97e-30 123.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1YFEW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T 7TM diverse intracellular signalling mmoS - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,CHASE5,HATPase_c,HisKA,Response_reg k59_699380_1 349521.HCH_02302 1.65e-59 187.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1XK7A@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_111259_1 1454004.AW11_02009 9.87e-247 699.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria 28216|Betaproteobacteria P Pfam Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_373099_1 1128398.Curi_c17530 9.93e-95 283.0 COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,268HW@186813|unclassified Clostridiales 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_405267_1 1165841.SULAR_05148 4.48e-134 394.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,42NTK@68525|delta/epsilon subdivisions,2YNFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_306686_1 1304880.JAGB01000002_gene2049 4.16e-17 82.4 COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1025993_2 42565.FP66_12520 6.31e-13 69.7 COG2207@1|root,COG2207@2|Bacteria,1Q3UX@1224|Proteobacteria,1RS88@1236|Gammaproteobacteria,1XHJN@135619|Oceanospirillales 135619|Oceanospirillales K helix_turn_helix, arabinose operon control protein - - - ko:K04033 - - - - ko00000,ko03000 - - - HTH_18 k59_145325_1 768671.ThimaDRAFT_4344 1.39e-95 289.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1X2CM@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_44333_1 990073.ATHU01000001_gene1787 3.3e-103 305.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,42NE5@68525|delta/epsilon subdivisions,2YNF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_470519_1 864069.MicloDRAFT_00069260 2.64e-72 229.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JSA1@119045|Methylobacteriaceae 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_862608_1 690850.Desaf_0495 2.15e-74 237.0 COG2367@1|root,COG2367@2|Bacteria,1R6KF@1224|Proteobacteria,42YYI@68525|delta/epsilon subdivisions,2WTQR@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Beta-lactamase enzyme family - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_437455_1 631362.Thi970DRAFT_01389 1.39e-147 424.0 COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,1RSIM@1236|Gammaproteobacteria,1WW7Y@135613|Chromatiales 135613|Chromatiales C reductase, dissimilatory-type alpha subunit - - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_731422_1 86416.Clopa_4709 1.92e-168 474.0 COG1028@1|root,COG1028@2|Bacteria,1TQ3V@1239|Firmicutes,24ARQ@186801|Clostridia,36DXG@31979|Clostridiaceae 186801|Clostridia IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_994455_1 929558.SMGD1_2613 2.13e-141 410.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2YMHJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_145334_1 1283300.ATXB01000001_gene2076 7.29e-45 157.0 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1XEX3@135618|Methylococcales 135618|Methylococcales K Peptidase_C39 like family - - - - - - - - - - - - Acetyltransf_1,DUF3335 k59_929339_1 572544.Ilyop_1831 1.95e-41 146.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - pilI - - - - - - - - - - - ABC2_membrane_2 k59_306702_1 29760.VIT_10s0116g00060.t01 6.39e-63 206.0 COG0649@1|root,COG1005@1|root,KOG2870@2759|Eukaryota,KOG4770@2759|Eukaryota,37KKG@33090|Viridiplantae,3GDNP@35493|Streptophyta 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhH GO:0003674,GO:0003824,GO:0003959,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0015979,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0019866,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0032991,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0055035,GO:0055114,GO:0070469,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K05572,ko:K05579 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Complex1_49kDa,Fer4,NADHdh k59_306702_2 59689.scaffold_900034.1 7.59e-268 735.0 COG0649@1|root,KOG2870@2759|Eukaryota,37KKG@33090|Viridiplantae,3GDNP@35493|Streptophyta,3I15P@3699|Brassicales 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhH GO:0003674,GO:0003824,GO:0003959,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0015979,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0019866,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0032991,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0055035,GO:0055114,GO:0070469,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K05572,ko:K05579 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Complex1_49kDa,NADHdh k59_306702_3 981085.XP_010111576.1 3.69e-37 128.0 COG0184@1|root,KOG2815@2759|Eukaryota,37W6V@33090|Viridiplantae,3GKIP@35493|Streptophyta 35493|Streptophyta J 30S ribosomal protein S15 rps15 GO:0000312,GO:0000313,GO:0000314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0009507,GO:0009532,GO:0009536,GO:0009547,GO:0009570,GO:0015935,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_699763_1 1123288.SOV_5c00220 6.54e-132 385.0 COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,4H1VG@909932|Negativicutes 909932|Negativicutes V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_699763_2 1123326.JFBL01000021_gene2577 2.8e-06 58.2 COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,42Q7M@68525|delta/epsilon subdivisions,2YNPH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU outer membrane protein, TolC family - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP k59_699763_3 572544.Ilyop_1240 4.86e-71 224.0 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - LolA_like k59_699763_4 665571.STHERM_c02070 1.88e-20 100.0 COG4591@1|root,COG4591@2|Bacteria,2JA02@203691|Spirochaetes 203691|Spirochaetes M ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_699763_5 237368.SCABRO_01939 0.000278 46.6 COG4591@1|root,COG4591@2|Bacteria,2IY15@203682|Planctomycetes 203682|Planctomycetes M ABC-type transport system involved in lipoprotein release permease component - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_569375_1 1244869.H261_01547 1.2e-42 154.0 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria,2JWSB@204441|Rhodospirillales 204441|Rhodospirillales C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_569375_2 1244869.H261_01552 6.83e-74 226.0 COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2UJSY@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome c oxidase (Subunit II) - - - - - - - - - - - - - k59_994463_1 756272.Plabr_3405 0.000258 42.7 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_16,GerE,Response_reg k59_994463_2 1279015.KB908458_gene2485 1.2e-13 75.9 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1Y3KC@135624|Aeromonadales 135624|Aeromonadales E homoserine dehydrogenase metL - 1.1.1.3,2.7.2.4 ko:K12525 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Homoserine_dh,NAD_binding_3 k59_145343_1 927658.AJUM01000034_gene43 3.97e-50 180.0 COG3179@1|root,COG3179@2|Bacteria,4NF8K@976|Bacteroidetes,2G28X@200643|Bacteroidia,3XKDJ@558415|Marinilabiliaceae 976|Bacteroidetes S fibronectin type III domain protein - - - - - - - - - - - - fn3 k59_505084_2 1280941.HY2_08905 6.74e-26 106.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TRCK@28211|Alphaproteobacteria,43WQW@69657|Hyphomonadaceae 28211|Alphaproteobacteria E COG0339 Zn-dependent oligopeptidases - - 3.4.15.5 ko:K01284 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_437472_1 713586.KB900536_gene651 4.06e-68 229.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales 135613|Chromatiales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_569379_2 794846.AJQU01000087_gene4749 1.87e-22 95.9 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2TQQQ@28211|Alphaproteobacteria,4B7VV@82115|Rhizobiaceae 28211|Alphaproteobacteria C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_341579_1 1042156.CXIVA_17790 2.52e-31 124.0 COG2271@1|root,COG2271@2|Bacteria,1VR8X@1239|Firmicutes 1239|Firmicutes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_242002_1 765913.ThidrDRAFT_1980 5.52e-104 313.0 COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria,1WWGR@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_177753_1 1137281.D778_02675 2.23e-30 124.0 COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - HTH_18,TPR_2,TPR_8 k59_306716_1 1121403.AUCV01000004_gene1915 3.22e-33 131.0 2DB8F@1|root,2Z7RQ@2|Bacteria,1NA57@1224|Proteobacteria,43311@68525|delta/epsilon subdivisions,2WYB9@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_929355_1 388399.SSE37_09028 2.41e-12 66.6 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_341584_1 1173022.Cri9333_3496 1.71e-167 492.0 COG0367@1|root,COG0367@2|Bacteria,1G1WZ@1117|Cyanobacteria,1H9W9@1150|Oscillatoriales 1117|Cyanobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_994478_1 686340.Metal_3316 9.6e-138 410.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XDNZ@135618|Methylococcales 135618|Methylococcales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_111604_1 1384056.N787_01505 5.91e-30 117.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1X361@135614|Xanthomonadales 135614|Xanthomonadales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_7 k59_111604_2 314278.NB231_16288 1.58e-15 74.7 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1WW0C@135613|Chromatiales 135613|Chromatiales F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_635024_1 1046714.AMRX01000003_gene482 2.6e-92 275.0 COG3409@1|root,COG3409@2|Bacteria,1R4RS@1224|Proteobacteria,1S346@1236|Gammaproteobacteria 1236|Gammaproteobacteria M CHAP domain - - - - - - - - - - - - CHAP k59_8544_1 1168034.FH5T_04020 2.06e-105 317.0 COG0147@1|root,COG0147@2|Bacteria,4NFQ5@976|Bacteroidetes,2FN6I@200643|Bacteroidia 976|Bacteroidetes EH Anthranilate synthase component I trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_437491_1 1168034.FH5T_04765 1.08e-103 306.0 COG0253@1|root,COG0253@2|Bacteria,4NF26@976|Bacteroidetes,2FNI4@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_896156_1 1121440.AUMA01000023_gene2046 2.66e-38 147.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CDW@68525|delta/epsilon subdivisions,2X7X2@28221|Deltaproteobacteria,2MHFY@213115|Desulfovibrionales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_44374_1 335543.Sfum_0677 2.11e-88 277.0 COG5016@1|root,COG5016@2|Bacteria 2|Bacteria C pyruvate - - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01958,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_569401_1 1095769.CAHF01000013_gene3185 4.48e-53 176.0 COG2220@1|root,COG2220@2|Bacteria,1PH47@1224|Proteobacteria,2WAZ6@28216|Betaproteobacteria,4786C@75682|Oxalobacteraceae 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - - k59_994483_1 367737.Abu_0213 4.48e-53 179.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2YMRR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3 k59_862650_1 1278073.MYSTI_01818 1.69e-13 75.1 COG2021@1|root,COG2021@2|Bacteria,1NRWW@1224|Proteobacteria 1224|Proteobacteria E TAP-like protein - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_111611_1 471870.BACINT_00978 3.46e-37 139.0 COG1435@1|root,COG1435@2|Bacteria,4NE0A@976|Bacteroidetes,2FN01@200643|Bacteroidia,4AVTA@815|Bacteroidaceae 976|Bacteroidetes F Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_111611_2 471870.BACINT_00979 1.43e-60 208.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FM2D@200643|Bacteroidia,4AK7X@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_273422_1 1049564.TevJSym_ap00570 5.47e-98 296.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1J4GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1026051_1 208596.CAR_c21150 5.2e-103 315.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,27H8H@186828|Carnobacteriaceae 91061|Bacilli G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_505119_1 485918.Cpin_5296 7.02e-12 71.6 COG0236@1|root,COG0500@1|root,COG0604@1|root,COG1028@1|root,COG2227@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0604@2|Bacteria,COG1028@2|Bacteria,COG2226@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,1IPC0@117747|Sphingobacteriia 976|Bacteroidetes IQ Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_699799_1 1249480.B649_06645 4.3e-105 313.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2YM81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Cysteine desulfurase iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_405331_1 1121405.dsmv_3693 1.54e-122 358.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - ko:K07497 - - - - ko00000 - - - EIIA-man,HTH_21,PRD,PTS_EIIA_2,Sigma54_activat,rve k59_799814_22 335543.Sfum_4094 2.36e-87 267.0 COG1152@1|root,COG1152@2|Bacteria,1R9TR@1224|Proteobacteria,42NQK@68525|delta/epsilon subdivisions,2WKI3@28221|Deltaproteobacteria,2MR78@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - - k59_799814_23 429009.Adeg_1334 3.95e-53 182.0 COG2048@1|root,COG2048@2|Bacteria,1U4JW@1239|Firmicutes,24C8P@186801|Clostridia,42FS6@68295|Thermoanaerobacterales 186801|Clostridia C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_799814_24 477974.Daud_0563 2.69e-09 60.5 COG1150@1|root,COG1150@2|Bacteria,1V8UM@1239|Firmicutes,24J4U@186801|Clostridia,2622W@186807|Peptococcaceae 186801|Clostridia C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4_17,Fer4_8 k59_799814_25 517418.Ctha_0632 3.27e-102 318.0 COG2838@1|root,COG2838@2|Bacteria,1FDPE@1090|Chlorobi 1090|Chlorobi C PFAM Isocitrate dehydrogenase NADP-dependent monomeric type - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_13614_1 1168034.FH5T_00630 1.75e-126 374.0 COG1069@1|root,COG1069@2|Bacteria,4NEFQ@976|Bacteroidetes,2FNNI@200643|Bacteroidia 976|Bacteroidetes G Belongs to the ribulokinase family araB - 2.7.1.16 ko:K00853 ko00040,ko01100,map00040,map01100 - R01526,R02439 RC00002,RC00538 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_736747_1 742725.HMPREF9450_01252 4.59e-76 248.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,4NEM0@976|Bacteroidetes,2FWDE@200643|Bacteroidia 976|Bacteroidetes IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 k59_574895_1 349521.HCH_06867 2.75e-22 98.6 COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,1RYVF@1236|Gammaproteobacteria,1XRXC@135619|Oceanospirillales 135619|Oceanospirillales S Putative exonuclease SbcCD, C subunit - - - - - - - - - - - - AAA_29,SbcCD_C k59_475978_1 929558.SMGD1_0751 7.67e-45 156.0 COG0795@1|root,COG0795@2|Bacteria,1PXEK@1224|Proteobacteria,42MVG@68525|delta/epsilon subdivisions,2YN6F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S permease - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_475978_2 563040.Saut_1653 2.19e-27 105.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2YP7I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_966806_1 1235788.C802_03433 7.05e-137 409.0 COG1506@1|root,COG1506@2|Bacteria,4PMGM@976|Bacteroidetes,2FPGH@200643|Bacteroidia,4AKIG@815|Bacteroidaceae 976|Bacteroidetes E Abhydrolase family - - - - - - - - - - - - AXE1 k59_966809_1 443143.GM18_0501 5.47e-84 264.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - - - - - - - - - - - GIIM,RVT_1 k59_901343_2 1219072.VHA01S_090_00050 1.35e-16 73.2 2EG1V@1|root,339TV@2|Bacteria,1NI0B@1224|Proteobacteria,1SGIA@1236|Gammaproteobacteria,1XZ4Y@135623|Vibrionales 135623|Vibrionales S Domain of unknown function (DUF4250) BT4646 - - - - - - - - - - - DUF4250 k59_901343_3 1408439.JHXW01000009_gene404 8.67e-120 349.0 COG1540@1|root,COG1540@2|Bacteria,379I4@32066|Fusobacteria 32066|Fusobacteria S Belongs to the UPF0271 (lamB) family - - - ko:K07160 - - - - ko00000 - - - LamB_YcsF k59_901343_4 742740.HMPREF9474_00390 0.000158 43.1 COG2049@1|root,COG2049@2|Bacteria,1TTBZ@1239|Firmicutes,24A35@186801|Clostridia,220CF@1506553|Lachnoclostridium 186801|Clostridia E Psort location Cytoplasmic, score 8.87 kipI - - ko:K06351 - - - - ko00000 - - - CT_C_D k59_999939_1 748658.KB907319_gene774 2.4e-44 158.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1S1NC@1236|Gammaproteobacteria,1X06R@135613|Chromatiales 135613|Chromatiales T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_934547_1 323848.Nmul_A0617 2.34e-82 258.0 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,2VIGZ@28216|Betaproteobacteria,372V2@32003|Nitrosomonadales 28216|Betaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - Mur_ligase_M,PGA_cap k59_378453_1 572544.Ilyop_1159 5.15e-10 65.1 COG0028@1|root,COG0028@2|Bacteria,378RW@32066|Fusobacteria 32066|Fusobacteria H acetolactate synthase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_799831_1 1279017.AQYJ01000025_gene707 5.21e-128 391.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,465IV@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - EcoEI_R_C,HSDR_N,Helicase_C,ResIII k59_574902_1 563040.Saut_0098 1.65e-55 181.0 COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,42QTH@68525|delta/epsilon subdivisions,2YNUH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_966821_1 1168034.FH5T_18815 1.32e-74 226.0 COG1943@1|root,COG1943@2|Bacteria,4NWI3@976|Bacteroidetes,2FZ9S@200643|Bacteroidia 976|Bacteroidetes L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_705388_1 1249480.B649_00935 8.15e-05 43.9 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,42N84@68525|delta/epsilon subdivisions,2YM7V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0510 DapB_C,DapB_N k59_705388_2 1249480.B649_00930 4.94e-73 228.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2YN1K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_736753_1 395494.Galf_2622 1.72e-15 76.3 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2VV78@28216|Betaproteobacteria 28216|Betaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_13621_2 862908.BMS_3032 4.05e-40 141.0 2AFPW@1|root,315RN@2|Bacteria,1N1K1@1224|Proteobacteria,42WWK@68525|delta/epsilon subdivisions,2WSXP@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1031419_1 1249480.B649_10210 1.57e-102 305.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2YMMA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iIT341.HP0202 ACP_syn_III,ACP_syn_III_C k59_835928_1 387093.SUN_1435 5.71e-162 464.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YNAB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DEAD DEAH box helicase deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C k59_705395_1 396588.Tgr7_2113 4.03e-60 206.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_49563_1 34506.g3280 8.53e-26 107.0 COG0216@1|root,COG1190@1|root,KOG1885@2759|Eukaryota,KOG2726@2759|Eukaryota,38C95@33154|Opisthokonta,3BE5C@33208|Metazoa,3CTVI@33213|Bilateria,40C8Z@6231|Nematoda,1KTYS@119089|Chromadorea,40ZQN@6236|Rhabditida 33208|Metazoa J tRNA synthetases class II (D, K and N) - GO:0000003,GO:0001932,GO:0001934,GO:0007275,GO:0007568,GO:0008150,GO:0008340,GO:0009892,GO:0009893,GO:0010259,GO:0010468,GO:0010562,GO:0010604,GO:0010605,GO:0010629,GO:0019220,GO:0019222,GO:0022414,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032504,GO:0042325,GO:0042327,GO:0044703,GO:0044706,GO:0045937,GO:0048518,GO:0048519,GO:0048522,GO:0048580,GO:0048582,GO:0048609,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051171,GO:0051173,GO:0051174,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051704,GO:0060255,GO:0060378,GO:0061062,GO:0061063,GO:0065007,GO:0065008,GO:0080090,GO:2000026 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_84048_1 760192.Halhy_2051 1.75e-46 169.0 COG0642@1|root,COG0745@1|root,COG2114@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria 2|Bacteria T PhoQ Sensor - - 4.6.1.1 ko:K01768,ko:K16923,ko:K19694 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00582,M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.28 - - 7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_1031430_1 709032.Sulku_2265 1.02e-82 275.0 COG2199@1|root,COG3221@1|root,COG3437@1|root,COG2199@2|Bacteria,COG3221@2|Bacteria,COG3437@2|Bacteria,1RGCV@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,HD k59_607890_1 929558.SMGD1_2693 1.28e-162 475.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2YMEF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M penicillin-binding protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_117070_1 649638.Trad_0763 1.47e-31 127.0 COG1459@1|root,COG1459@2|Bacteria,1WIU3@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus NU PFAM Bacterial type II secretion system protein F domain pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_868202_1 398720.MED217_13651 1.08e-63 207.0 COG0438@1|root,COG0438@2|Bacteria,4NEJ6@976|Bacteroidetes,1HYVG@117743|Flavobacteriia 976|Bacteroidetes M glycosyl transferase family 1 - - - - - - - - - - - - DUF1972,Glycos_transf_1 k59_215895_1 177437.HRM2_15690 1.72e-76 247.0 COG2204@1|root,COG5001@1|root,COG2204@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2MIPM@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM EAL domain - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_736769_1 1539298.JO41_01050 1.05e-10 63.5 COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes 203691|Spirochaetes G PFAM FGGY family of carbohydrate kinases, N-terminal domain - - 2.7.1.12,2.7.1.17 ko:K00851,ko:K00854 ko00030,ko00040,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map01100,map01110,map01120,map01130,map01200 M00014 R01639,R01737 RC00002,RC00017,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_999977_1 749222.Nitsa_1420 9.41e-85 266.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2YMW3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM Belongs to the mannose-6-phosphate isomerase type 2 family manC - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_215898_1 1165841.SULAR_07153 1.89e-88 287.0 COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2YSXK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I CoA enzyme activase uncharacterised domain (DUF2229) - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_183389_1 1284775.HMPREF1640_02100 0.000878 41.6 COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,2FM0P@200643|Bacteroidia 976|Bacteroidetes G beta-galactosidase lacZ - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_183389_2 558884.JRGM01000009_gene3346 8.64e-100 295.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,1Y3SW@135624|Aeromonadales 135624|Aeromonadales P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_934585_1 305900.GV64_01955 8.78e-38 137.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XIU7@135619|Oceanospirillales 135619|Oceanospirillales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_934585_2 511062.GU3_03320 7.17e-27 109.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1Y5JC@135624|Aeromonadales 135624|Aeromonadales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_49611_1 713586.KB900536_gene2121 1.06e-45 159.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1WWG8@135613|Chromatiales 135613|Chromatiales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_49611_2 1123514.KB905899_gene1679 9e-28 112.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,45ZQY@72273|Thiotrichales 72273|Thiotrichales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_13654_1 85643.Tmz1t_0110 2.11e-109 355.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,2KVBJ@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_347184_1 1265505.ATUG01000001_gene3966 1.14e-131 386.0 COG2271@1|root,COG2271@2|Bacteria,1QYDE@1224|Proteobacteria,43CG4@68525|delta/epsilon subdivisions,2X7R5@28221|Deltaproteobacteria,2MPQ9@213118|Desulfobacterales 28221|Deltaproteobacteria G Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 k59_901373_1 1168034.FH5T_12195 1.27e-145 436.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,4NEHE@976|Bacteroidetes,2FM8K@200643|Bacteroidia 976|Bacteroidetes G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_934596_2 233412.HD_1815 4.6e-14 70.1 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1Y8X0@135625|Pasteurellales 135625|Pasteurellales P part of a sulfur-relay system tusE - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_934596_3 1266914.ATUK01000012_gene201 5.85e-24 92.0 2C2HW@1|root,32U3B@2|Bacteria,1N2W5@1224|Proteobacteria,1SA05@1236|Gammaproteobacteria,1WYXJ@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_347187_1 115417.EPrPW00000015939 8.03e-65 218.0 COG0076@1|root,KOG1383@2759|Eukaryota,1MAYK@121069|Pythiales 121069|Pythiales E Sphingosine-1-phosphate lyase. Source PGD - - - - - - - - - - - - Pyridoxal_deC k59_312190_1 396588.Tgr7_1129 1.98e-64 221.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_510662_1 387092.NIS_0792 2.79e-89 275.0 COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,42MUQ@68525|delta/epsilon subdivisions,2YMUB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium calcium exchanger membrane - - - ko:K07300 - - - - ko00000,ko02000 2.A.19 - - Na_Ca_ex k59_442938_1 754477.Q7C_1003 2.82e-105 317.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,45ZNA@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_705428_1 1121439.dsat_2748 1.19e-268 739.0 2CE5F@1|root,2Z7YQ@2|Bacteria,1MXVM@1224|Proteobacteria,42Q53@68525|delta/epsilon subdivisions,2WJY4@28221|Deltaproteobacteria,2MEC1@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_705428_2 1121405.dsmv_1786 8.96e-93 271.0 2BS3Y@1|root,32M4R@2|Bacteria,1NT2U@1224|Proteobacteria,42YW3@68525|delta/epsilon subdivisions,2WTV7@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_705428_3 1121439.dsat_2747 1.26e-29 105.0 2E3GE@1|root,32YF6@2|Bacteria,1N7MX@1224|Proteobacteria,42XUV@68525|delta/epsilon subdivisions,2WSST@28221|Deltaproteobacteria,2MCKM@213115|Desulfovibrionales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2188) - - - - - - - - - - - - DUF2188 k59_607922_1 1255043.TVNIR_3799 3.74e-186 531.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WW9R@135613|Chromatiales 135613|Chromatiales F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_799901_1 1168034.FH5T_14400 9.94e-58 189.0 COG4213@1|root,COG4213@2|Bacteria,4NNBW@976|Bacteroidetes,2FWT8@200643|Bacteroidia 976|Bacteroidetes G Periplasmic binding protein domain - - - ko:K10543 ko02010,map02010 M00215 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.4 - - Peripla_BP_4 k59_799901_2 1168034.FH5T_14395 7.11e-31 113.0 COG0424@1|root,COG0424@2|Bacteria,4NNXV@976|Bacteroidetes,2FKYZ@200643|Bacteroidia 976|Bacteroidetes D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_248414_1 105420.BBPO01000049_gene1758 0.000623 45.4 COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria,2NFVP@228398|Streptacidiphilus 201174|Actinobacteria KLT Protein tyrosine kinase pknJ - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_706250_1 572477.Alvin_0082 5.98e-27 112.0 COG0225@1|root,COG0229@1|root,COG0526@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,COG0526@2|Bacteria,1MVUS@1224|Proteobacteria,1T0T1@1236|Gammaproteobacteria,1X2MT@135613|Chromatiales 135613|Chromatiales CO Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11,1.8.4.12 ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR,Thioredoxin_2 k59_706250_2 768671.ThimaDRAFT_4831 2.76e-79 240.0 COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,1S7MH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DoxX family - - - ko:K15977 - - - - ko00000 - - - DoxX k59_706252_1 641491.DND132_2639 1.47e-66 225.0 COG0835@1|root,COG0835@2|Bacteria,1QVCF@1224|Proteobacteria,42M0F@68525|delta/epsilon subdivisions,2WUAE@28221|Deltaproteobacteria,2M93D@213115|Desulfovibrionales 28221|Deltaproteobacteria NT PFAM CheW domain protein - - - - - - - - - - - - CheW,dCache_1 k59_184182_1 1168034.FH5T_11110 6.41e-88 271.0 COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes,2FW6G@200643|Bacteroidia 976|Bacteroidetes M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_D23,OEP k59_411675_1 1049564.TevJSym_bo00200 4.36e-116 349.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Nitrite reductase nirS GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_312964_1 667632.KB890176_gene4476 2.16e-81 254.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,1K2JZ@119060|Burkholderiaceae 28216|Betaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_608755_1 566466.NOR53_2885 8.15e-47 174.0 COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria,1JADB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix, Lux Regulon malT GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030246,GO:0031323,GO:0031326,GO:0042802,GO:0044238,GO:0048031,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070492,GO:0071704,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE k59_967743_1 572544.Ilyop_0485 7.38e-118 366.0 COG0608@1|root,COG0608@2|Bacteria,378YV@32066|Fusobacteria 32066|Fusobacteria L Single-stranded-DNA-specific exonuclease recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_608758_1 56107.Cylst_5471 7.39e-72 241.0 COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,1HIEP@1161|Nostocales 1117|Cyanobacteria O TIGRFAM NiFe hydrogenase maturation protein HypF hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_151647_2 1123393.KB891316_gene2122 5.14e-70 219.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,1KT21@119069|Hydrogenophilales 119069|Hydrogenophilales E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_14625_1 3988.XP_002535618.1 9.94e-38 127.0 COG0740@1|root,KOG0840@2759|Eukaryota,37U4N@33090|Viridiplantae,3GICU@35493|Streptophyta,4JUJ9@91835|fabids 35493|Streptophyta O ATP-dependent Clp protease proteolytic clpP GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_411685_1 329726.AM1_1273 1.94e-43 161.0 COG0531@1|root,COG0531@2|Bacteria,1G248@1117|Cyanobacteria 1117|Cyanobacteria E Amino Acid - - - - - - - - - - - - AA_permease,SLC12 k59_706281_1 1408419.JHYG01000004_gene1416 6.49e-33 130.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2JS1T@204441|Rhodospirillales 204441|Rhodospirillales S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_16,TPR_19,TPR_8 k59_674502_1 536227.CcarbDRAFT_1549 6.36e-27 112.0 COG4076@1|root,COG4076@2|Bacteria,1UKYK@1239|Firmicutes,24FFX@186801|Clostridia,36F4F@31979|Clostridiaceae 186801|Clostridia Q 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - - k59_184203_1 1423144.Gal_00658 4.52e-17 82.0 2DP0X@1|root,3302S@2|Bacteria,1RIRD@1224|Proteobacteria,2UA7P@28211|Alphaproteobacteria,34GAU@302485|Phaeobacter 28211|Alphaproteobacteria S Protein of unknown function (DUF3306) - - - - - - - - - - - - DUF3306 k59_84968_1 1238182.C882_4103 2.49e-77 252.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,2JPBE@204441|Rhodospirillales 204441|Rhodospirillales I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_84968_2 1380394.JADL01000003_gene5065 2.13e-99 300.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQCM@204441|Rhodospirillales 204441|Rhodospirillales I Belongs to the thiolase family - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_443823_1 768671.ThimaDRAFT_4258 1.65e-39 142.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1WY02@135613|Chromatiales 135613|Chromatiales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_481031_1 1123354.AUDR01000013_gene704 1.29e-92 280.0 2C7Q9@1|root,2Z96K@2|Bacteria,1MWKA@1224|Proteobacteria,2VN2M@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_252734_1 1168034.FH5T_05805 3.31e-103 311.0 COG0673@1|root,COG0673@2|Bacteria,4NG5T@976|Bacteroidetes,2FPA2@200643|Bacteroidia 976|Bacteroidetes S Putative oxidoreductase C terminal domain - - - - - - - - - - - - GFO_IDH_MocA,Oxidoreduct_C k59_516145_1 637389.Acaty_c1617 3.85e-80 257.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,2NDQG@225057|Acidithiobacillales 225057|Acidithiobacillales L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_710618_1 316067.Geob_0397 6.67e-114 347.0 COG2766@1|root,COG2766@2|Bacteria,1PXNG@1224|Proteobacteria,42N5G@68525|delta/epsilon subdivisions,2WINM@28221|Deltaproteobacteria,43S13@69541|Desulfuromonadales 28221|Deltaproteobacteria T PrkA AAA domain prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_156029_1 566466.NOR53_2025 1.28e-07 55.1 COG2866@1|root,COG2866@2|Bacteria,1R490@1224|Proteobacteria,1RYIE@1236|Gammaproteobacteria 1236|Gammaproteobacteria M carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_156029_2 1517416.IDAT_03565 2.65e-50 174.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,2QFV9@267893|Idiomarinaceae 1236|Gammaproteobacteria P Sodium:sulfate symporter transmembrane region sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_220913_1 1172190.M947_04225 1.11e-27 107.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,42MXH@68525|delta/epsilon subdivisions,2YMN3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_220913_2 387092.NIS_0303 3.3e-49 166.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2YMKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_122444_1 572544.Ilyop_1081 5.63e-23 94.4 COG1057@1|root,COG1057@2|Bacteria,379PT@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_122444_2 1121335.Clst_1659 1.54e-14 70.9 COG0662@1|root,COG0662@2|Bacteria,1UI0P@1239|Firmicutes,24SCP@186801|Clostridia 186801|Clostridia G Cupin domain - - - - - - - - - - - - Cupin_2 k59_775787_1 1384054.N790_14535 2.77e-82 253.0 COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1RN1S@1236|Gammaproteobacteria,1X448@135614|Xanthomonadales 135614|Xanthomonadales L Exodeoxyribonuclease IX exo - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_415775_1 439235.Dalk_4071 6.61e-61 197.0 COG4822@1|root,COG4822@2|Bacteria,1P36Y@1224|Proteobacteria,42QYS@68525|delta/epsilon subdivisions,2WMZM@28221|Deltaproteobacteria,2MJFZ@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the insertion of Co(2 ) into sirohydrochlorin - - 4.99.1.3 ko:K02190 ko00860,ko01100,map00860,map01100 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiK k59_579875_1 709032.Sulku_1311 1.4e-91 272.0 COG2077@1|root,COG2077@2|Bacteria,1Q5WV@1224|Proteobacteria,431ZJ@68525|delta/epsilon subdivisions,2YSAN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O AhpC/TSA family - - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin k59_805096_1 1128398.Curi_c04210 5.07e-29 114.0 COG2050@1|root,COG2050@2|Bacteria,1VVXR@1239|Firmicutes,24K9M@186801|Clostridia 186801|Clostridia Q Putative thioesterase (yiiD_Cterm) - - - - - - - - - - - - YiiD_C k59_805096_2 883.DvMF_2793 5.77e-35 127.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2M9ST@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_188534_1 96561.Dole_2738 5.5e-72 241.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_678996_1 709032.Sulku_1242 1.57e-16 83.6 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43CKQ@68525|delta/epsilon subdivisions,2YTDV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V secretion protein HlyD - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_89566_1 118166.JH976537_gene2632 6e-59 191.0 COG2249@1|root,COG2249@2|Bacteria,1G57U@1117|Cyanobacteria,1HEJ4@1150|Oscillatoriales 1117|Cyanobacteria S Flavodoxin-like fold - - - ko:K03923,ko:K11748 - - - - ko00000,ko02000 2.A.37.1.2 - - Flavodoxin_2 k59_156062_1 709032.Sulku_2542 5.4e-101 314.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2YN94@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_54730_1 572544.Ilyop_1259 5.18e-136 416.0 COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,3784B@32066|Fusobacteria 32066|Fusobacteria H tRNA nucleotidyltransferase poly(A) polymerase - - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,NUDIX,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 k59_54730_2 573061.Clocel_3000 2.85e-185 529.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,36E1H@31979|Clostridiaceae 186801|Clostridia E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_54730_3 1319815.HMPREF0202_00258 9.66e-144 447.0 COG0729@1|root,COG1752@1|root,COG0729@2|Bacteria,COG1752@2|Bacteria,378P1@32066|Fusobacteria 32066|Fusobacteria M Psort location OuterMembrane, score - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_54730_4 469616.FMAG_01566 8.92e-144 432.0 COG1293@1|root,COG1293@2|Bacteria,378PV@32066|Fusobacteria 32066|Fusobacteria K Fibronectin-binding protein A FbpA - - - - - - - - - - - DUF814,FbpA k59_54730_5 572544.Ilyop_1315 4.47e-92 276.0 COG1846@1|root,COG1846@2|Bacteria,378Z3@32066|Fusobacteria 32066|Fusobacteria K Transcriptional regulator, MarR family - - - - - - - - - - - - MarR k59_54730_6 572544.Ilyop_1316 4.08e-114 331.0 COG0036@1|root,COG0036@2|Bacteria,379G5@32066|Fusobacteria 32066|Fusobacteria G Ribulose-phosphate 3-epimerase rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_54730_7 469616.FMAG_01569 1.45e-85 261.0 COG1162@1|root,COG1162@2|Bacteria,378YH@32066|Fusobacteria 32066|Fusobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N k59_679010_1 515620.EUBELI_00431 6.35e-84 261.0 COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,25VDK@186806|Eubacteriaceae 186801|Clostridia E Psort location Cytoplasmic, score glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_516831_1 1445613.JALM01000122_gene1279 0.000434 42.4 COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria,4DZM2@85010|Pseudonocardiales 201174|Actinobacteria S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L k59_516831_2 326427.Cagg_1960 3.69e-16 81.6 COG0438@1|root,COG0438@2|Bacteria,2G5KS@200795|Chloroflexi,374UR@32061|Chloroflexia 32061|Chloroflexia M PFAM glycosyl transferase group 1 - - 2.4.1.250 ko:K15521 - - - - ko00000,ko01000 - - - Glyco_transf_4,Glycos_transf_1 k59_711194_1 1121007.AUML01000085_gene1128 8.87e-87 268.0 COG3344@1|root,COG3344@2|Bacteria,4NGGU@976|Bacteroidetes,1HX5X@117743|Flavobacteriia,2YJW3@290174|Aquimarina 976|Bacteroidetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,Intron_maturas2,RVT_1 k59_548509_1 345201.TOP2_IIV3 2.53e-89 290.0 4QDCP@10239|Viruses,4QVJZ@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA gyrase B - GO:0005575,GO:0032991 - - - - - - - - - - - k59_776352_1 765913.ThidrDRAFT_3429 1.32e-43 162.0 COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WVXV@135613|Chromatiales 135613|Chromatiales CP Na H antiporter - - - ko:K05559 - - - - ko00000,ko02000 2.A.63.1 - - DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N k59_221466_2 2340.JV46_07290 1.19e-18 78.6 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1J6WB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_221466_4 187272.Mlg_0468 5.79e-74 222.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,1WY84@135613|Chromatiales 135613|Chromatiales J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_221466_5 1249627.D779_3561 1.86e-49 159.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1WYKG@135613|Chromatiales 135613|Chromatiales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_449068_1 1190603.AJYD01000081_gene300 2.86e-18 82.8 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1XTQ1@135623|Vibrionales 135623|Vibrionales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_449068_2 1158146.KB907121_gene1231 8.42e-12 65.9 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria,1WZ88@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1037268_2 1453501.JELR01000001_gene2564 2.12e-60 196.0 COG0421@1|root,COG0421@2|Bacteria,1QWZZ@1224|Proteobacteria,1T31M@1236|Gammaproteobacteria,467WD@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Methyltransf_25 k59_940245_1 709032.Sulku_1150 4.96e-74 243.0 COG4774@1|root,COG4774@2|Bacteria,1QU2Y@1224|Proteobacteria,43CFU@68525|delta/epsilon subdivisions,2YTF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M PFAM TonB-dependent Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - TonB_dep_Rec k59_580572_1 1085623.GNIT_3206 5.35e-08 54.3 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,469QG@72275|Alteromonadaceae 1236|Gammaproteobacteria P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_580572_2 224324.aq_468 1.15e-13 77.0 COG0845@1|root,COG0845@2|Bacteria,2G4TY@200783|Aquificae 200783|Aquificae M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 k59_221471_1 933262.AXAM01000001_gene342 6.24e-101 303.0 COG3383@1|root,COG3383@2|Bacteria,1QW12@1224|Proteobacteria,43BQY@68525|delta/epsilon subdivisions,2X5UH@28221|Deltaproteobacteria,2MHPH@213118|Desulfobacterales 28221|Deltaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain sfrA GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.17.1.10 ko:K05299 ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4,Fer4_10,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_221471_2 933262.AXAM01000001_gene343 6.36e-37 136.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MIGI@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM molybdopterin oxidoreductase - - 1.17.1.10,1.17.1.9 ko:K00123,ko:K05299 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_284331_1 713586.KB900536_gene2144 2.69e-34 129.0 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RNK7@1236|Gammaproteobacteria 1236|Gammaproteobacteria MP COG0226 ABC-type phosphate transport system, periplasmic component pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_253308_1 1415778.JQMM01000001_gene7 6.52e-90 270.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1J53H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_352742_2 1122176.KB903543_gene458 5.47e-24 94.0 2E3VP@1|root,32YSV@2|Bacteria,4NV28@976|Bacteroidetes,1IU7M@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_481464_1 1249480.B649_03320 2.81e-35 124.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2YTQW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH Anthranilate synthase trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_156801_1 709032.Sulku_2079 1.28e-92 281.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2YNUK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_711208_1 1168034.FH5T_14825 6.41e-159 454.0 COG0701@1|root,COG0701@2|Bacteria,4NDUJ@976|Bacteroidetes,2FNF8@200643|Bacteroidia 976|Bacteroidetes P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_805662_1 1469245.JFBG01000023_gene1280 2.98e-85 266.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1X2DA@135613|Chromatiales 135613|Chromatiales S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Reductase_C k59_90242_1 396588.Tgr7_0001 6.87e-179 509.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales 135613|Chromatiales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_317716_1 387093.SUN_1021 5.43e-120 350.0 COG1191@1|root,COG1943@1|root,COG1191@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2YPQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Transposase - - - - - - - - - - - - Y1_Tnp k59_548547_1 1235788.C802_03441 2.09e-52 186.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FW53@200643|Bacteroidia,4AWE5@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_841581_1 1280680.AUJU01000035_gene3672 2.4e-18 92.8 COG3250@1|root,COG3408@1|root,COG3250@2|Bacteria,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,4BW95@830|Butyrivibrio 186801|Clostridia G Bacterial alpha-L-rhamnosidase C-terminal domain - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,FIVAR k59_352753_1 572544.Ilyop_0379 1.57e-56 184.0 COG0489@1|root,COG0489@2|Bacteria,37BKG@32066|Fusobacteria 32066|Fusobacteria D PFAM CobQ CobB MinD ParA nucleotide binding domain - - - - - - - - - - - - AAA_31 k59_352753_2 1243664.CAVL020000006_gene4959 7.4e-10 59.3 COG4464@1|root,COG4464@2|Bacteria,1TQ1T@1239|Firmicutes,4HDZR@91061|Bacilli,1ZDH3@1386|Bacillus 91061|Bacilli GM COG4464 Capsular polysaccharide biosynthesis protein ywqE - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - - k59_156817_1 1123400.KB904753_gene1056 9.69e-24 94.4 COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,1SD0G@1236|Gammaproteobacteria,4631U@72273|Thiotrichales 72273|Thiotrichales P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_156817_2 1144342.PMI40_04100 4.39e-09 55.5 COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2VU96@28216|Betaproteobacteria,474IC@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - SnoaL_3 k59_613829_1 879212.DespoDRAFT_01578 9.78e-15 72.0 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,42S37@68525|delta/epsilon subdivisions,2WNDZ@28221|Deltaproteobacteria,2MJWJ@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_613829_2 1265505.ATUG01000002_gene2254 4.92e-60 198.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,42NWR@68525|delta/epsilon subdivisions,2WK2E@28221|Deltaproteobacteria,2MI90@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - DUF3450,MotA_ExbB k59_873953_1 314287.GB2207_09656 5.31e-56 200.0 COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,1RP6B@1236|Gammaproteobacteria,1J4RA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_776387_1 1268240.ATFI01000004_gene3885 6.81e-50 171.0 COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,2FM5A@200643|Bacteroidia,4AMKB@815|Bacteroidaceae 976|Bacteroidetes L COG3328 Transposase and inactivated derivatives - - - - - - - - - - - - Transposase_mut k59_646436_1 1168034.FH5T_20355 3.11e-146 435.0 COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes 976|Bacteroidetes E Aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_711227_1 1165841.SULAR_03492 6.54e-69 213.0 COG2128@1|root,COG2128@2|Bacteria,1PZ9M@1224|Proteobacteria,42PYF@68525|delta/epsilon subdivisions,2YNK8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_940287_1 391625.PPSIR1_42251 6.51e-10 64.7 COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,42UR3@68525|delta/epsilon subdivisions,2WQQQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM geranylgeranyl reductase - - - - - - - - - - - - FAD_binding_3 k59_646440_1 96561.Dole_0295 5.87e-74 234.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2WN0Z@28221|Deltaproteobacteria,2MHV6@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM glycoside hydrolase family 3 domain protein - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C k59_221506_1 768066.HELO_4467 2.44e-102 311.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1XH6E@135619|Oceanospirillales 135619|Oceanospirillales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_873965_1 1168034.FH5T_12645 1.78e-40 141.0 COG0576@1|root,COG0576@2|Bacteria,4NQ6M@976|Bacteroidetes,2FPIN@200643|Bacteroidia 976|Bacteroidetes O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_516894_1 1205753.A989_05447 1.42e-79 256.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales 135614|Xanthomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_613843_1 2340.JV46_28500 6.1e-110 327.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,1J5B3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component urtA - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_156845_1 563040.Saut_0234 9.18e-185 522.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2YMUV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_156845_2 563040.Saut_0233 1.19e-64 199.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,42SRC@68525|delta/epsilon subdivisions,2YP4I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_156845_3 1172190.M947_07360 9.92e-91 266.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2YNWB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_580635_1 247633.GP2143_08885 1.24e-40 148.0 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,1RMJH@1236|Gammaproteobacteria,1J5FT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG2829 Outer membrane phospholipase A pldA - 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - PLA1 k59_776409_1 1232410.KI421424_gene1792 2.84e-41 155.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,43TW3@69541|Desulfuromonadales 28221|Deltaproteobacteria C NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_711244_1 1565314.OA34_04985 1.21e-150 448.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2YN9X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_548590_1 525898.Sdel_2138 6.28e-16 86.3 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42R1U@68525|delta/epsilon subdivisions,2YNX6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PAS domain - - - - - - - - - - - - HATPase_c,PAS_3,PAS_9 k59_776413_1 763034.HMPREF9446_01511 1.8e-06 51.2 COG0763@1|root,COG0763@2|Bacteria,4NDW3@976|Bacteroidetes,2FPE5@200643|Bacteroidia,4AKF3@815|Bacteroidaceae 976|Bacteroidetes M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_776413_2 1168034.FH5T_03010 2.64e-42 154.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,2FQ8Z@200643|Bacteroidia 976|Bacteroidetes N ABC-type uncharacterized transport system gldG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_520969_1 556267.HWAG_00475 7.54e-27 109.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2YMBT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L ATP-dependent DNA helicase recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_520969_2 717231.Flexsi_1738 6.47e-29 112.0 COG0399@1|root,COG4970@1|root,COG0399@2|Bacteria,COG4970@2|Bacteria,2GG3H@200930|Deferribacteres 200930|Deferribacteres NU UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - - - - - - - - - - N_methyl k59_485308_1 1122947.FR7_1349 1.49e-19 92.4 COG0491@1|root,COG0491@2|Bacteria,1V8E9@1239|Firmicutes 1239|Firmicutes S Zn-dependent hydrolases including glyoxylases-like protein - - - - - - - - - - - - Lactamase_B k59_161463_1 1123228.AUIH01000010_gene4002 2.09e-39 140.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,1XPHQ@135619|Oceanospirillales 135619|Oceanospirillales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_257490_1 713586.KB900536_gene154 2.47e-52 170.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,1WZIV@135613|Chromatiales 135613|Chromatiales S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_94070_1 439235.Dalk_1765 3.05e-32 122.0 COG0287@1|root,COG0287@2|Bacteria,1MVUT@1224|Proteobacteria,42Q2P@68525|delta/epsilon subdivisions,2WMC9@28221|Deltaproteobacteria,2MJU2@213118|Desulfobacterales 28221|Deltaproteobacteria E prephenate dehydrogenase tyrA - 1.3.1.12,5.4.99.5 ko:K04517,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R01715,R01728 RC00125,RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,PDH,PDT k59_780801_2 1298608.JCM18900_1527 0.000201 49.3 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1MY4A@1224|Proteobacteria,1S13D@1236|Gammaproteobacteria,3NTC1@468|Moraxellaceae 1236|Gammaproteobacteria M Outer membrane protein beta-barrel domain - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA k59_976483_1 645991.Sgly_0707 1.99e-11 62.8 COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,262IA@186807|Peptococcaceae 186801|Clostridia S protein, YerC YecD - - - - - - - - - - - - Trp_repressor k59_976483_2 1121413.JMKT01000012_gene579 8.47e-15 72.8 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,42WCF@68525|delta/epsilon subdivisions,2WRES@28221|Deltaproteobacteria,2MFJ9@213115|Desulfovibrionales 28221|Deltaproteobacteria S Mycobacterial 4 TMS phage holin, superfamily IV - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_94078_1 1168034.FH5T_06125 5.51e-78 244.0 COG1253@1|root,COG1253@2|Bacteria,4NG0I@976|Bacteroidetes,2FMR1@200643|Bacteroidia 976|Bacteroidetes S Psort location CytoplasmicMembrane, score tlyC - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_878038_1 391625.PPSIR1_18997 3.96e-14 73.6 2D3S1@1|root,32TFH@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_618193_1 1121405.dsmv_3567 2.36e-65 201.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,42RE3@68525|delta/epsilon subdivisions,2WPD5@28221|Deltaproteobacteria,2MK1T@213118|Desulfobacterales 28221|Deltaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_553191_1 1168034.FH5T_18330 6.37e-55 192.0 COG0457@1|root,COG0457@2|Bacteria,4P3PK@976|Bacteroidetes 976|Bacteroidetes S Tetratricopeptide repeats - - - - - - - - - - - - - k59_257510_1 1121937.AUHJ01000007_gene1892 3.36e-98 296.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,465C3@72275|Alteromonadaceae 1236|Gammaproteobacteria I desaturase desC - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_193605_1 1454007.JAUG01000106_gene1047 4.38e-05 52.4 COG4198@1|root,COG4198@2|Bacteria,4NI11@976|Bacteroidetes,1IRPM@117747|Sphingobacteriia 976|Bacteroidetes S Starch-binding associating with outer membrane - - - - - - - - - - - - SusD-like k59_321373_2 1168034.FH5T_18230 2.75e-109 328.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,2FNCD@200643|Bacteroidia 976|Bacteroidetes I Carboxyl transferase domain protein - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1041951_1 1265313.HRUBRA_01717 5.68e-29 105.0 COG1396@1|root,COG1396@2|Bacteria,1NGFD@1224|Proteobacteria,1SGW1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_1041951_2 1265313.HRUBRA_01716 9.27e-62 201.0 COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RPQR@1236|Gammaproteobacteria,1JBCV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pfam:HipA_N hipA_1 - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_288817_1 439235.Dalk_4306 4.39e-25 100.0 COG0727@1|root,COG0727@2|Bacteria,1REPM@1224|Proteobacteria,42RPZ@68525|delta/epsilon subdivisions,2WNSE@28221|Deltaproteobacteria,2MIBR@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC k59_809507_1 713586.KB900536_gene1465 7.64e-94 293.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales 135613|Chromatiales C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_746357_1 1121918.ARWE01000001_gene186 8e-70 224.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,42N4S@68525|delta/epsilon subdivisions,2WJXX@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM amine oxidase - - - - - - - - - - - - Amino_oxidase k59_225863_1 929556.Solca_3283 5.9e-54 186.0 COG0815@1|root,COG0815@2|Bacteria,4NG4X@976|Bacteroidetes,1IQGK@117747|Sphingobacteriia 976|Bacteroidetes M apolipoprotein N-acyltransferase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_585250_1 1041504.RATSFB_0609 3.95e-09 58.5 COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia,36I5N@31979|Clostridiaceae 186801|Clostridia K cyclic nucleotide-binding - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_845307_1 1168034.FH5T_20260 1.12e-26 110.0 COG2273@1|root,COG2273@2|Bacteria,4NQU3@976|Bacteroidetes,2FT4I@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolases family 16 - - - - - - - - - - - - Glyco_hydro_16 k59_225872_1 266835.14021592 1.73e-14 74.3 29APY@1|root,2ZXPR@2|Bacteria,1R817@1224|Proteobacteria,2TSBC@28211|Alphaproteobacteria,43HYI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF1849) MA20_36210 - - - - - - - - - - - DUF1849 k59_225872_2 1532558.JL39_30160 5.38e-32 120.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TQPQ@28211|Alphaproteobacteria,4BBCE@82115|Rhizobiaceae 28211|Alphaproteobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase hprA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_257528_2 563040.Saut_1918 1.52e-69 219.0 COG1385@1|root,COG1385@2|Bacteria,1QDSD@1224|Proteobacteria,42S1W@68525|delta/epsilon subdivisions,2YP9M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_585257_1 290402.Cbei_5004 3.88e-22 96.7 COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,36F6A@31979|Clostridiaceae 186801|Clostridia K GntR domain protein - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR k59_650270_1 1541883.A0A088FVG5_9CAUD 2.1e-58 202.0 4QAZJ@10239|Viruses,4QPFF@28883|Caudovirales,4QJS9@10662|Myoviridae 10662|Myoviridae S virion assembly - - - - - - - - - - - - - k59_715272_1 1249480.B649_10555 1.71e-91 283.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YNDA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_780826_1 572544.Ilyop_0206 1.24e-94 283.0 COG0224@1|root,COG0224@2|Bacteria,378FI@32066|Fusobacteria 32066|Fusobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_520990_1 240016.ABIZ01000001_gene5341 2.05e-08 54.3 COG3287@1|root,COG3287@2|Bacteria 2|Bacteria M FIST C domain - - - - - - - - - - - - FIST,FIST_C,GGDEF k59_420236_1 396588.Tgr7_2901 9.9e-40 153.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X29W@135613|Chromatiales 135613|Chromatiales NT chemotaxis - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_585262_1 1537917.JU82_01790 3.62e-45 152.0 2AJZN@1|root,31ANZ@2|Bacteria,1Q5WH@1224|Proteobacteria,42UJ4@68525|delta/epsilon subdivisions,2YPXB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_585262_2 1537917.JU82_01795 7.94e-53 166.0 COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,42V85@68525|delta/epsilon subdivisions,2YPSA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Nitrogen fixation protein NifU - - - - - - - - - - - - NifU k59_585262_3 563040.Saut_0294 8.42e-40 145.0 COG0667@1|root,COG0667@2|Bacteria,1RHYD@1224|Proteobacteria,42SEU@68525|delta/epsilon subdivisions,2YT8N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_746380_1 1198232.CYCME_0809 2.15e-81 255.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,4607U@72273|Thiotrichales 72273|Thiotrichales S modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_127021_2 1485545.JQLW01000001_gene1428 1.5e-37 134.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria 1224|Proteobacteria F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHODB_Fe-S_bind,DHO_dh,NAD_binding_1 k59_520997_1 1380600.AUYN01000001_gene2409 1.08e-74 233.0 COG2896@1|root,COG2896@2|Bacteria,4NFS9@976|Bacteroidetes,1HWK6@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_485373_1 572544.Ilyop_0856 1.81e-64 199.0 2ESSS@1|root,33KB5@2|Bacteria,37CS9@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF2628) - - - - - - - - - - - - DUF2628 k59_878071_1 926564.KI911635_gene2883 2.37e-49 157.0 COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4F4SN@85017|Promicromonosporaceae 201174|Actinobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_878071_2 1123065.ATWL01000019_gene2145 5.06e-49 158.0 COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria 201174|Actinobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_94114_1 1165841.SULAR_07188 5.29e-104 318.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2YMW2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_257535_1 944547.ABLL_1416 7.81e-40 141.0 COG0745@1|root,COG0745@2|Bacteria,1N8XN@1224|Proteobacteria,42WCI@68525|delta/epsilon subdivisions,2YRPH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_257535_2 944547.ABLL_1415 5.47e-56 185.0 2B2M3@1|root,31V6H@2|Bacteria,1QT2M@1224|Proteobacteria,42ZNF@68525|delta/epsilon subdivisions,2YRQ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_257535_4 1244083.CSUNSWCD_1204 8.24e-05 44.7 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2YMBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1055 Na H antiporter NhaD and related arsenite - - - - - - - - - - - - CitMHS k59_650285_1 1168034.FH5T_02815 4.87e-24 96.7 COG1309@1|root,COG1309@2|Bacteria,4NIBT@976|Bacteroidetes,2FU2E@200643|Bacteroidia 976|Bacteroidetes K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_650285_2 1168034.FH5T_02820 1.42e-29 116.0 COG1538@1|root,COG1538@2|Bacteria,4NFSW@976|Bacteroidetes,2FNYU@200643|Bacteroidia 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_618230_2 929558.SMGD1_0948 7.11e-46 151.0 COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42U0X@68525|delta/epsilon subdivisions,2YPSD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 k59_521006_1 1384056.N787_05610 1.63e-14 69.3 COG1695@1|root,COG1695@2|Bacteria,1NJSY@1224|Proteobacteria,1SG6R@1236|Gammaproteobacteria,1X6UG@135614|Xanthomonadales 135614|Xanthomonadales K PadR family transcriptional regulator - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR k59_521006_2 935863.AWZR01000005_gene2173 1.82e-36 132.0 COG4709@1|root,COG4709@2|Bacteria,1NX5K@1224|Proteobacteria,1SPS6@1236|Gammaproteobacteria,1X34I@135614|Xanthomonadales 135614|Xanthomonadales S Putative sensor - - - - - - - - - - - - Sensor k59_809556_1 1122135.KB893167_gene2384 4.92e-72 243.0 COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2TQXU@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_225912_1 44251.PDUR_09815 2.45e-18 82.8 COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,4HIVC@91061|Bacilli,26Y6J@186822|Paenibacillaceae 91061|Bacilli S thioesterase yneP - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_225912_2 1167006.UWK_02766 1.39e-46 163.0 COG0319@1|root,COG0854@1|root,COG0319@2|Bacteria,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,2MJ54@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1885 PdxJ k59_553243_1 936455.KI421499_gene6394 6.53e-104 314.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,3JS5B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_257543_1 436114.SYO3AOP1_1417 9.12e-126 376.0 COG4826@1|root,COG4826@2|Bacteria 2|Bacteria O serine-type endopeptidase inhibitor activity - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin k59_976566_1 1249480.B649_01505 2.61e-119 351.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2YMR4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_23947_1 717605.Theco_1455 0.000278 43.5 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,26TK1@186822|Paenibacillaceae 91061|Bacilli L DNA polymerase - - - - - - - - - - - - GIIM,RVT_1 k59_1009579_1 1121405.dsmv_0479 1.27e-142 415.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MIHR@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_553249_1 523845.AQXV01000055_gene64 4.48e-16 82.8 arCOG14662@1|root,arCOG14662@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_618248_1 1121374.KB891585_gene2406 1.29e-40 150.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria 1236|Gammaproteobacteria PT cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_715301_2 1123053.AUDG01000031_gene952 2.6e-18 87.4 COG1262@1|root,COG1520@1|root,COG2931@1|root,COG3209@1|root,COG1262@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,1QX0G@1224|Proteobacteria,1T32B@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - - k59_845363_1 944547.ABLL_2143 8.85e-108 322.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42N1V@68525|delta/epsilon subdivisions 1224|Proteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family ectB - 2.6.1.19,2.6.1.22,2.6.1.76 ko:K00836,ko:K07250 ko00250,ko00260,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00280,map00410,map00640,map00650,map01100,map01120,map01210,map01230 M00027,M00033 R00908,R01648,R04188,R06977 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_845363_2 344747.PM8797T_20418 7.64e-24 96.3 COG0454@1|root,COG0456@2|Bacteria,2J3NX@203682|Planctomycetes 203682|Planctomycetes K Acetyltransferase (GNAT) domain - - 2.3.1.178 ko:K06718 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06978 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_321423_1 314285.KT71_01845 1.23e-68 223.0 COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D von Willebrand factor (VWF) type A domain - - - - - - - - - - - - VWA_2 k59_420263_1 1265505.ATUG01000002_gene1250 1.11e-18 85.5 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BR8@68525|delta/epsilon subdivisions,2X724@28221|Deltaproteobacteria,2MPMS@213118|Desulfobacterales 28221|Deltaproteobacteria T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Sigma54_activat k59_809586_1 1185652.USDA257_c25000 2.29e-31 124.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,2VF65@28211|Alphaproteobacteria,4BBA2@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase for insertion sequence element - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_357484_1 1168034.FH5T_08720 2.49e-71 237.0 COG3947@1|root,COG3947@2|Bacteria,4NFJU@976|Bacteroidetes,2FN4F@200643|Bacteroidia 976|Bacteroidetes T COG NOG26059 non supervised orthologous group - - - - - - - - - - - - Laminin_G_3 k59_455336_1 1121396.KB893115_gene3165 5.23e-62 208.0 COG4916@1|root,COG4916@2|Bacteria,1RBBR@1224|Proteobacteria 1224|Proteobacteria S TIR domain - - - - - - - - - - - - SIR2_2,TIR_2 k59_485869_1 484770.UFO1_3160 2.52e-48 161.0 COG1082@1|root,COG1082@2|Bacteria,1UZXE@1239|Firmicutes,4H2VV@909932|Negativicutes 909932|Negativicutes G PFAM Xylose isomerase domain-containing protein TIM barrel - - - ko:K06605 - - - - ko00000 - - - AP_endonuc_2 k59_390500_1 1168034.FH5T_21950 1.62e-35 128.0 COG0061@1|root,COG0061@2|Bacteria,4NFG5@976|Bacteroidetes,2FMTM@200643|Bacteroidia 976|Bacteroidetes H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_390500_2 1168034.FH5T_21945 5.73e-57 184.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - - - - - - - - - - - k59_554073_1 765914.ThisiDRAFT_2647 1.49e-37 137.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1WWXY@135613|Chromatiales 135613|Chromatiales S Permease YjgP YjgQ - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_554073_2 472759.Nhal_3016 3.54e-38 133.0 COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,1WYQZ@135613|Chromatiales 135613|Chromatiales S pfam rdd - - - - - - - - - - - - RDD k59_258216_1 765911.Thivi_2069 1.34e-111 329.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1WWX5@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_684470_1 879212.DespoDRAFT_01051 8.13e-94 276.0 COG0494@1|root,COG0494@2|Bacteria,1Q5JU@1224|Proteobacteria,42RPC@68525|delta/epsilon subdivisions,2WNUK@28221|Deltaproteobacteria,2MJX1@213118|Desulfobacterales 28221|Deltaproteobacteria L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_33724_2 469618.FVAG_02650 0.0 1043.0 COG0010@1|root,COG1982@1|root,COG0010@2|Bacteria,COG1982@2|Bacteria,379MA@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Arginase,OKR_DC_1,OKR_DC_1_C k59_33724_3 1392488.JHZY01000002_gene1254 3.44e-21 97.1 2BRKZ@1|root,32KKB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_33724_4 1207076.ALAT01000089_gene1015 4.46e-42 144.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1Z1MZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria G Peptidyl-prolyl cis-trans slyD GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010467,GO:0016151,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022417,GO:0031647,GO:0035821,GO:0036211,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043963,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0046872,GO:0046914,GO:0050821,GO:0050896,GO:0050897,GO:0051082,GO:0051604,GO:0051701,GO:0051704,GO:0051817,GO:0052027,GO:0052250,GO:0065007,GO:0065008,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_33724_6 1408439.JHXW01000008_gene306 1.06e-104 310.0 COG4123@1|root,COG4123@2|Bacteria,379AV@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - MTS,Methyltransf_31 k59_622141_1 146922.JOFU01000002_gene7589 1.43e-21 103.0 COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria 201174|Actinobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_556842_1 946362.XP_004990496.1 2.97e-07 51.2 COG0480@1|root,COG0515@1|root,KOG0465@2759|Eukaryota,KOG1026@2759|Eukaryota,38GUI@33154|Opisthokonta 33154|Opisthokonta J translation elongation factor activity MEF1 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0031974,GO:0032543,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0070125,GO:0071704,GO:0097159,GO:0097367,GO:0140053,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_752919_1 1168034.FH5T_17760 7.84e-138 412.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,4NF2R@976|Bacteroidetes,2FQYA@200643|Bacteroidia 976|Bacteroidetes HJ Belongs to the D-alanine--D-alanine ligase family - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_720259_1 1122179.KB890497_gene2838 2.54e-73 247.0 COG1409@1|root,COG2312@1|root,COG1409@2|Bacteria,COG2312@2|Bacteria,4PP0J@976|Bacteroidetes 976|Bacteroidetes E CotH kinase protein - - - - - - - - - - - - CHB_HEX_C_1,CotH,LTD k59_66338_1 1120973.AQXL01000107_gene1990 0.000176 43.9 COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli,278WP@186823|Alicyclobacillaceae 91061|Bacilli S Aldo/keto reductase family yvgN - - - - - - - - - - - Aldo_ket_red k59_131791_1 1168034.FH5T_20515 2.45e-81 254.0 COG0025@1|root,COG0025@2|Bacteria,4NK07@976|Bacteroidetes,2FVV3@200643|Bacteroidia 976|Bacteroidetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_785543_1 709032.Sulku_0142 3.16e-121 379.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2YMTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_818267_1 1209989.TepiRe1_2310 1.33e-98 293.0 COG3717@1|root,COG3717@2|Bacteria,1TP4X@1239|Firmicutes,24A00@186801|Clostridia,42FHM@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_99124_1 572544.Ilyop_0846 4.78e-45 157.0 COG4380@1|root,COG4380@2|Bacteria 2|Bacteria D Lipoprotein - - - - - - - - - - - - CsgG,DUF799,Gly-zipper_Omp,NosD,SPOR,TPR_16,TPR_2 k59_99124_2 572544.Ilyop_0847 2.2e-35 124.0 COG1799@1|root,COG1799@2|Bacteria,37AHQ@32066|Fusobacteria 32066|Fusobacteria D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA - - - ko:K09772 - - - - ko00000,ko03036 - - - SepF k59_99124_3 1348657.M622_03365 4.2e-25 103.0 COG3124@1|root,COG3124@2|Bacteria,1MZ59@1224|Proteobacteria,2VSFW@28216|Betaproteobacteria,2KWV1@206389|Rhodocyclales 206389|Rhodocyclales S Acyl carrier protein phosphodiesterase - - - - - - - - - - - - ACP_PD k59_99124_4 572544.Ilyop_0796 1.53e-286 809.0 COG0744@1|root,COG0744@2|Bacteria,379FN@32066|Fusobacteria 32066|Fusobacteria M penicillin-binding protein 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_99124_5 1408439.JHXW01000002_gene602 1.48e-179 508.0 COG0820@1|root,COG0820@2|Bacteria,37847@32066|Fusobacteria 32066|Fusobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_99124_6 935836.JAEL01000142_gene4178 2.44e-130 387.0 COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,4H9PE@91061|Bacilli,1ZCQC@1386|Bacillus 91061|Bacilli E COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities patB - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_393410_2 1123240.ATVO01000003_gene436 3.27e-45 154.0 2DYTE@1|root,34B1B@2|Bacteria,1R2N3@1224|Proteobacteria,2TZNZ@28211|Alphaproteobacteria,2KBIA@204457|Sphingomonadales 1123240.ATVO01000003_gene436|- S PEP-CTERM motif - - - - - - - - - - - - - k59_33741_1 204669.Acid345_4083 9.51e-59 199.0 COG1195@1|root,COG3593@1|root,COG1195@2|Bacteria,COG3593@2|Bacteria,3Y7ZQ@57723|Acidobacteria 57723|Acidobacteria L Protein of unknown function (DUF2813) - - - ko:K07459 - - - - ko00000 - - - DUF2813 k59_851043_1 1499967.BAYZ01000155_gene629 1.22e-66 214.0 COG0116@1|root,COG0116@2|Bacteria 2|Bacteria L 23S rRNA (guanine(2445)-N(2))-methyltransferase activity rlmL GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.173,2.1.1.264 ko:K07444,ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_99128_1 688245.CtCNB1_4470 2.07e-25 104.0 COG0421@1|root,COG1586@1|root,COG0421@2|Bacteria,COG1586@2|Bacteria,1MVV5@1224|Proteobacteria,2WGFP@28216|Betaproteobacteria,4ACQW@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc,Spermine_synt_N,Spermine_synth k59_131813_1 1123059.KB823011_gene844 0.000151 45.1 COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,2UBYN@28211|Alphaproteobacteria,43Y84@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1863 Multisubunit Na H antiporter, MnhE subunit - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_131813_2 1415778.JQMM01000001_gene1294 2.68e-35 122.0 COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,1SE40@1236|Gammaproteobacteria,1J6KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Multiple resistance and pH regulation protein F (MrpF / PhaF) mnhF - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k59_393419_2 929703.KE386491_gene1828 9.88e-25 114.0 COG3307@1|root,COG3307@2|Bacteria 2|Bacteria M -O-antigen - - - - - - - - - - - - Wzy_C k59_458796_1 1501391.LG35_07600 2.67e-30 114.0 COG0731@1|root,COG0731@2|Bacteria,4NJEM@976|Bacteroidetes,2FMWY@200643|Bacteroidia,22UDB@171550|Rikenellaceae 976|Bacteroidetes C radical SAM domain protein - - - - - - - - - - - - Fer4_14,Radical_SAM k59_687604_2 944547.ABLL_1829 8.47e-48 159.0 2ETDC@1|root,33KX5@2|Bacteria,1P8PA@1224|Proteobacteria,42UDD@68525|delta/epsilon subdivisions,2YPXG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF420) - - - ko:K08976 - - - - ko00000 - - - DUF420 k59_785568_1 1288494.EBAPG3_20990 5.16e-95 287.0 COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,371YT@32003|Nitrosomonadales 28216|Betaproteobacteria P Bacterial extracellular solute-binding protein fbpA - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_687607_1 683083.C414_000450060 2.04e-18 85.5 COG0242@1|root,COG0606@1|root,COG0242@2|Bacteria,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2YMTY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Mg chelatase-related protein comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_687607_2 572480.Arnit_2419 9.24e-45 150.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2YMBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_524202_1 439235.Dalk_3276 1.65e-26 109.0 COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,42UTS@68525|delta/epsilon subdivisions,2WQM7@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_524202_2 1123247.AUIJ01000017_gene2716 6.41e-59 190.0 COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VEYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria E branched-chain amino acid MA20_09940 - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_33766_1 155515.JP36_05015 1.07e-18 91.7 COG2911@1|root,COG3209@1|root,COG3210@1|root,COG4932@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1T1ZX@1236|Gammaproteobacteria,1YAZ6@135625|Pasteurellales 135625|Pasteurellales M domain protein - - - - - - - - - - - - - k59_426005_1 86416.Clopa_4050 6.86e-109 324.0 COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,36DDS@31979|Clostridiaceae 186801|Clostridia E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_524207_1 387093.SUN_0525 4.32e-64 219.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,42M8I@68525|delta/epsilon subdivisions,2YN4J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 k59_66380_2 760117.JN27_01130 2.8e-33 124.0 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2VGZX@28216|Betaproteobacteria,475T3@75682|Oxalobacteraceae 28216|Betaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_589573_1 1168067.JAGP01000001_gene1538 1.49e-73 228.0 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,1RMKM@1236|Gammaproteobacteria,462AX@72273|Thiotrichales 72273|Thiotrichales S KR domain - - - - - - - - - - - - adh_short k59_360784_1 1165841.SULAR_05128 8.15e-131 395.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2YMS4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_687619_1 765910.MARPU_04225 2.44e-69 231.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_328128_1 1123400.KB904772_gene3330 1.42e-116 342.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,460VQ@72273|Thiotrichales 72273|Thiotrichales S PFAM Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - - - - - - - - - - LigB k59_328128_2 1230342.CTM_15118 0.000459 43.1 COG3976@1|root,COG3976@2|Bacteria,1VM1F@1239|Firmicutes,24QU1@186801|Clostridia,36N8G@31979|Clostridiaceae 186801|Clostridia S FMN_bind - - - - - - - - - - - - FMN_bind k59_165427_1 1266998.ATUJ01000001_gene2825 1.89e-83 257.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2TSD6@28211|Alphaproteobacteria,2PVE5@265|Paracoccus 28211|Alphaproteobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_884285_1 385682.AFSL01000039_gene156 1.32e-87 273.0 COG2160@1|root,COG2160@2|Bacteria,4NHGG@976|Bacteroidetes,2FMIU@200643|Bacteroidia,3XJ54@558415|Marinilabiliaceae 976|Bacteroidetes G L-arabinose isomerase araA - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Iso_C,Arabinose_Isome k59_622852_1 595460.RRSWK_05984 4.36e-132 388.0 COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes 203682|Planctomycetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_67004_1 556267.HWAG_01108 2.04e-28 113.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2YMKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_67004_2 1249480.B649_05400 8.99e-88 273.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2YMGS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_590231_1 1335757.SPICUR_04490 2.54e-77 246.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_949825_1 1165841.SULAR_10119 3.04e-72 227.0 COG3705@1|root,COG3705@2|Bacteria,1QV6Q@1224|Proteobacteria,43BNS@68525|delta/epsilon subdivisions,2YT9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - - - - - - - - - - tRNA-synt_His k59_328829_1 1168034.FH5T_15375 4.29e-68 212.0 COG0325@1|root,COG0325@2|Bacteria,4NE42@976|Bacteroidetes,2FM94@200643|Bacteroidia 976|Bacteroidetes S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis yggS - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_328829_2 1168034.FH5T_15380 2.11e-44 153.0 COG0167@1|root,COG0167@2|Bacteria,4NF4D@976|Bacteroidetes,2FM0X@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the conversion of dihydroorotate to orotate preA - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_1363_1 1049564.TevJSym_ac00780 1.02e-35 134.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4Q2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleR - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_786225_1 1121035.AUCH01000004_gene429 1.54e-160 500.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_1015080_1 933262.AXAM01000025_gene3420 3.82e-96 306.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MHQW@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_34251_3 1173020.Cha6605_1035 1.94e-34 122.0 COG4679@1|root,COG4679@2|Bacteria,1G6VG@1117|Cyanobacteria 1117|Cyanobacteria S Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 k59_34251_4 546267.NEIPOLOT_02534 6.31e-17 76.6 COG5606@1|root,COG5606@2|Bacteria,1N2FN@1224|Proteobacteria,2VX6H@28216|Betaproteobacteria,2KS5R@206351|Neisseriales 206351|Neisseriales K Helix-turn-helix domain - - - - - - - - - - - - HTH_37 k59_34251_6 530564.Psta_1556 5.13e-71 224.0 29525@1|root,2ZSEY@2|Bacteria,2IZ8U@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_34251_12 340099.Teth39_0706 2.14e-43 150.0 COG2128@1|root,COG2128@2|Bacteria,1VAK9@1239|Firmicutes,24YCS@186801|Clostridia,42HY6@68295|Thermoanaerobacterales 186801|Clostridia C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_34251_13 1304885.AUEY01000009_gene1949 7.51e-123 363.0 COG4977@1|root,COG4977@2|Bacteria,1QTV9@1224|Proteobacteria,43CQR@68525|delta/epsilon subdivisions,2X7Y7@28221|Deltaproteobacteria,2MPPF@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_N,HTH_18 k59_34251_14 443144.GM21_0834 9.28e-208 583.0 COG1979@1|root,COG1979@2|Bacteria,1QUBJ@1224|Proteobacteria,42MPI@68525|delta/epsilon subdivisions,2WJGY@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Iron-containing alcohol dehydrogenase bdhA - 1.1.1.1 ko:K00001,ko:K08325 ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R02528,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC00739,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_34251_15 1515746.HR45_05120 4.16e-75 228.0 COG1917@1|root,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,1S3RV@1236|Gammaproteobacteria,2QCDA@267890|Shewanellaceae 1236|Gammaproteobacteria S Cupin domain - - - - - - - - - - - - Cupin_2 k59_34251_16 1116472.MGMO_103c00140 9.79e-126 373.0 COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,1T3H9@1236|Gammaproteobacteria,1XDWD@135618|Methylococcales 135618|Methylococcales H Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_34251_17 1116472.MGMO_103c00130 2.09e-81 248.0 COG1309@1|root,COG1309@2|Bacteria,1N1X6@1224|Proteobacteria,1S9GI@1236|Gammaproteobacteria,1XDKS@135618|Methylococcales 135618|Methylococcales K PFAM Transcriptional regulator, TetR-like, DNA-binding, bacterial archaeal - - - - - - - - - - - - TetR_N k59_34251_18 765911.Thivi_1686 0.0 998.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,1RMBA@1236|Gammaproteobacteria,1WWZR@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 k59_34251_19 472759.Nhal_1251 6.05e-114 338.0 COG0583@1|root,COG0583@2|Bacteria,1MUIX@1224|Proteobacteria,1RRF3@1236|Gammaproteobacteria,1WXTB@135613|Chromatiales 135613|Chromatiales K LysR family - - - ko:K03576 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_949831_1 572544.Ilyop_0818 2.39e-109 326.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups gtf1 GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758 2.4.1.52 ko:K00712 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_A_1,Glycos_transf_1 k59_426607_1 1454007.JAUG01000017_gene1477 6.44e-65 219.0 COG1048@1|root,COG1048@2|Bacteria,4NDZT@976|Bacteroidetes 976|Bacteroidetes C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_394106_1 156978.CIMIT_10510 2.09e-63 210.0 COG0280@1|root,COG0280@2|Bacteria,2GJ5U@201174|Actinobacteria,22JPM@1653|Corynebacteriaceae 201174|Actinobacteria C phosphate acetyltransferase pta GO:0005575,GO:0005576 2.3.1.8 ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,DRTGG,PTA_PTB k59_917227_1 1183438.GKIL_4246 3.01e-52 185.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1G23H@1117|Cyanobacteria 1117|Cyanobacteria G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway - - 2.2.1.2,5.3.1.9 ko:K00616,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000 - - - PGI,TAL_FSA k59_590251_1 1034809.SLUG_16830 1.36e-07 62.8 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,4GY5R@90964|Staphylococcaceae 91061|Bacilli KLT Serine threonine protein kinase prkC GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_721002_1 1122180.Lokhon_01497 4.99e-48 169.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,2P8F7@245186|Loktanella 28211|Alphaproteobacteria J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_655805_1 76114.ebA4396 3.44e-72 226.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,2KVPQ@206389|Rhodocyclales 206389|Rhodocyclales C Zinc-binding dehydrogenase qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_328860_1 1049564.TevJSym_ax00180 1.05e-36 135.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,1RZVF@1236|Gammaproteobacteria,1JBWE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M NlpB/DapX lipoprotein bamC - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_328860_2 768066.HELO_3578 1.71e-38 137.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1XJCR@135619|Oceanospirillales 135619|Oceanospirillales S beta-lactamase - - - - - - - - - - - - Lactamase_B_2 k59_1385_1 1121129.KB903359_gene1289 8.68e-34 128.0 COG0795@1|root,COG0795@2|Bacteria,4NE8B@976|Bacteroidetes,2FP6P@200643|Bacteroidia,22XC3@171551|Porphyromonadaceae 976|Bacteroidetes S Permease, YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1385_2 1168034.FH5T_01215 4.7e-27 101.0 COG3832@1|root,COG3832@2|Bacteria,4NNY1@976|Bacteroidetes,2FSYB@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - AHSA1 k59_361579_1 1168034.FH5T_17205 3.38e-171 496.0 COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NKE3@976|Bacteroidetes,2FNTG@200643|Bacteroidia 976|Bacteroidetes M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA k59_197965_1 1304885.AUEY01000022_gene3413 2.28e-35 137.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_34280_1 765914.ThisiDRAFT_1543 3.04e-52 172.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1WX5V@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_789850_1 1187848.AJYQ01000003_gene410 4.06e-110 332.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_985953_1 997884.HMPREF1068_03740 1.33e-74 249.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FW53@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_103936_1 224308.BSU17210 7.64e-74 250.0 COG1020@1|root,COG1028@1|root,COG3321@1|root,COG4221@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HTBC@91061|Bacilli,1ZS7J@1386|Bacillus 91061|Bacilli IQ polyketide synthase - - - ko:K13611,ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_70764_1 522772.Dacet_0784 2.9e-32 129.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - - - - - - - - - - Paired_CXXCH_1 k59_822814_1 225937.HP15_482 2.09e-65 224.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,465BS@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0067 Glutamate synthase domain 1 gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1018876_1 1122931.AUAE01000032_gene3001 2.01e-39 147.0 COG2264@1|root,COG2264@2|Bacteria 2|Bacteria J protein methyltransferase activity prmA - 2.1.1.222,2.1.1.64 ko:K00568,ko:K02687 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000,ko03009 - - - Methyltransf_12,Methyltransf_21,Methyltransf_23,Methyltransf_25,Methyltransf_31,PrmA k59_887316_2 1232437.KL662036_gene2712 1.5e-25 102.0 COG0748@1|root,COG0748@2|Bacteria,1N6EJ@1224|Proteobacteria,42W5F@68525|delta/epsilon subdivisions,2WRHB@28221|Deltaproteobacteria,2MKR5@213118|Desulfobacterales 28221|Deltaproteobacteria P Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx k59_887316_3 1121937.AUHJ01000002_gene3571 1.37e-23 110.0 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,465TD@72275|Alteromonadaceae 1236|Gammaproteobacteria T 7TMR-DISM extracellular 2 - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF k59_887316_4 926561.KB900621_gene2791 1.39e-84 259.0 COG1296@1|root,COG1296@2|Bacteria,1TSXD@1239|Firmicutes,24CRN@186801|Clostridia 186801|Clostridia E branched-chain amino acid permease (azaleucine resistance) - - - - - - - - - - - - AzlC k59_887316_5 394503.Ccel_2596 4.3e-13 67.0 COG4392@1|root,COG4392@2|Bacteria,1VAKN@1239|Firmicutes,24N0I@186801|Clostridia,36MR3@31979|Clostridiaceae 186801|Clostridia S branched-chain amino acid transport - - - - - - - - - - - - AzlD k59_887316_7 443143.GM18_1302 2.62e-49 170.0 COG0716@1|root,COG1149@1|root,COG0716@2|Bacteria,COG1149@2|Bacteria,1QWP4@1224|Proteobacteria,43BU4@68525|delta/epsilon subdivisions,2X754@28221|Deltaproteobacteria 28221|Deltaproteobacteria C FMN binding - - - - - - - - - - - - Fer4 k59_887316_8 469618.FVAG_00124 1.35e-83 256.0 COG0340@1|root,COG0340@2|Bacteria,379WY@32066|Fusobacteria 32066|Fusobacteria H biotin acetyl-CoA-carboxylase ligase - - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_LplA_LipB k59_887316_9 1122918.KB907252_gene2941 9.27e-98 300.0 COG3239@1|root,COG3239@2|Bacteria,1TP3B@1239|Firmicutes,4H9TS@91061|Bacilli,26RAC@186822|Paenibacillaceae 91061|Bacilli I Fatty acid desaturase des - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_887316_11 742767.HMPREF9456_01795 4.52e-58 187.0 COG0778@1|root,COG0778@2|Bacteria,4NPZV@976|Bacteroidetes,2FNIP@200643|Bacteroidia,22XS9@171551|Porphyromonadaceae 976|Bacteroidetes C nitroreductase - - - - - - - - - - - - Nitroreductase k59_887316_12 1304284.L21TH_1163 2.03e-296 837.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,36FU3@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31 k59_887316_13 525318.HMPREF0497_1149 3.25e-07 50.4 29Z15@1|root,30KYA@2|Bacteria,1U79F@1239|Firmicutes,4IH4A@91061|Bacilli,3F95H@33958|Lactobacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_887316_14 1120985.AUMI01000018_gene2952 3.58e-23 101.0 COG2326@1|root,COG2326@2|Bacteria,1TQQR@1239|Firmicutes,4H3PJ@909932|Negativicutes 909932|Negativicutes S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_953241_2 1249480.B649_10220 7.16e-29 114.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YMN1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DEAD box helicase family deaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C k59_691925_1 1265502.KB905946_gene1129 7.98e-37 131.0 COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,4AE1P@80864|Comamonadaceae 28216|Betaproteobacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_2 k59_169637_1 706587.Desti_0038 2.28e-22 103.0 COG0457@1|root,COG1352@1|root,COG0457@2|Bacteria,COG1352@2|Bacteria,1R6N1@1224|Proteobacteria,42NZW@68525|delta/epsilon subdivisions,2WMDS@28221|Deltaproteobacteria 28221|Deltaproteobacteria NT PFAM MCP methyltransferase, CheR-type - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,TPR_16,TPR_8 k59_3536_1 572544.Ilyop_1902 1.11e-128 386.0 COG0445@1|root,COG0445@2|Bacteria,3783J@32066|Fusobacteria 32066|Fusobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA1 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_691933_1 439235.Dalk_2974 1.19e-60 208.0 COG0642@1|root,COG2199@1|root,COG3437@1|root,COG0642@2|Bacteria,COG3437@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WK8V@28221|Deltaproteobacteria,2MHZC@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_235129_2 1168034.FH5T_12380 3.25e-83 251.0 COG0491@1|root,COG0491@2|Bacteria,4NE2Y@976|Bacteroidetes,2FSQ1@200643|Bacteroidia 976|Bacteroidetes P Metallo-beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k59_823566_1 697282.Mettu_0405 3.51e-81 267.0 COG3459@1|root,COG3459@2|Bacteria,1R1HB@1224|Proteobacteria,1T531@1236|Gammaproteobacteria,1XG0G@135618|Methylococcales 135618|Methylococcales G Glycosyltransferase 36 associated - - - - - - - - - - - - - k59_790323_1 1121405.dsmv_3737 1.09e-131 381.0 COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,42N5K@68525|delta/epsilon subdivisions,2WK1G@28221|Deltaproteobacteria,2MHYP@213118|Desulfobacterales 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase bamA GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 ko:K07539 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05593,R05594,R10696 RC01430,RC01431,RC03237 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_627444_1 635013.TherJR_2416 3.23e-132 388.0 COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,248TR@186801|Clostridia,2621Y@186807|Peptococcaceae 186801|Clostridia E PFAM Beta-eliminating lyase ltaE - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_627444_2 572544.Ilyop_1329 7.1e-215 649.0 COG2176@1|root,COG2176@2|Bacteria,378MN@32066|Fusobacteria 32066|Fusobacteria L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T k59_888170_1 879212.DespoDRAFT_02110 5.21e-99 308.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42MBP@68525|delta/epsilon subdivisions,2WJAJ@28221|Deltaproteobacteria,2MHTN@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_104871_1 1121012.AUKX01000064_gene1072 1.71e-162 464.0 COG3943@1|root,COG3943@2|Bacteria,4NEGN@976|Bacteroidetes,1HYIM@117743|Flavobacteriia,23HK1@178469|Arenibacter 976|Bacteroidetes S Virulence protein RhuM family - - - - - - - - - - - - Fic,Virulence_RhuM k59_235138_1 2340.JV46_26510 4.17e-18 80.5 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1J6GJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane protein, required for colicin V production cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - ko:K03558 - - - - ko00000 - - - Colicin_V k59_235138_2 395493.BegalDRAFT_0164 2.03e-133 392.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,4604I@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_104873_1 1304865.JAGF01000001_gene3845 2.4e-156 448.0 COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4F1S2@85016|Cellulomonadaceae 201174|Actinobacteria P Ammonium Transporter Family amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_366119_2 313595.P700755_000356 2.47e-57 187.0 COG0259@1|root,COG0259@2|Bacteria,4NFH7@976|Bacteroidetes,1HXWH@117743|Flavobacteriia,4C2CJ@83612|Psychroflexus 976|Bacteroidetes H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx k59_235141_1 765910.MARPU_11070 2.06e-54 192.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales 135613|Chromatiales L TIGRFAM ATP-dependent helicase HrpA - - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_823578_2 1286171.EAL2_808p01470 2.67e-08 54.3 COG1595@1|root,COG1595@2|Bacteria,1V3EU@1239|Firmicutes,249YR@186801|Clostridia,25XKW@186806|Eubacteriaceae 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_529931_1 859653.HIMB5_00008580 1.59e-90 278.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BPA4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component dctM1 - - - - - - - - - - - DctM k59_953974_1 1408473.JHXO01000007_gene803 3.16e-43 151.0 COG0436@1|root,COG0436@2|Bacteria,4NJTV@976|Bacteroidetes,2FMKZ@200643|Bacteroidia 976|Bacteroidetes E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_1_2 k59_953974_2 869213.JCM21142_41956 7.43e-53 174.0 COG0778@1|root,COG0778@2|Bacteria,4NKRC@976|Bacteroidetes 976|Bacteroidetes C Nitroreductase family - - - - - - - - - - - - Nitroreductase,TM1586_NiRdase k59_922057_2 553220.CAMGR0001_1815 6.19e-40 138.0 COG1652@1|root,COG1652@2|Bacteria,1NKUE@1224|Proteobacteria,42XJJ@68525|delta/epsilon subdivisions 1224|Proteobacteria S LysM domain - - - - - - - - - - - - DUF4398,LysM k59_71779_1 1235803.C825_01154 1.85e-18 89.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FWW6@200643|Bacteroidia,22X0F@171551|Porphyromonadaceae 976|Bacteroidetes H CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec k59_986909_2 1157490.EL26_12020 3.65e-30 120.0 COG0297@1|root,COG1543@1|root,COG0297@2|Bacteria,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,4HD14@91061|Bacilli,2795I@186823|Alicyclobacillaceae 91061|Bacilli G Domain of unknown function (DUF1957) - - 2.4.1.18 ko:K16149 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000 - GH57 - DUF1957,Glyco_hydro_57,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_398464_2 1168034.FH5T_10415 2.88e-16 76.6 28MFD@1|root,2ZASV@2|Bacteria,4NH4N@976|Bacteroidetes,2FQXU@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_366129_1 929558.SMGD1_1206 2.06e-133 384.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2YMNC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_366129_2 1537917.JU82_00560 6.66e-21 88.2 COG0421@1|root,COG0421@2|Bacteria,1PD55@1224|Proteobacteria,42UAB@68525|delta/epsilon subdivisions,2YPTY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_953979_1 1165841.SULAR_06168 6.4e-39 133.0 COG2406@1|root,COG2406@2|Bacteria,1RE25@1224|Proteobacteria,42PJ1@68525|delta/epsilon subdivisions,2YMUJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ferritin - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_430552_1 1131812.JQMS01000001_gene2837 6.23e-68 227.0 COG2272@1|root,COG2272@2|Bacteria,4NF5N@976|Bacteroidetes,1HZ06@117743|Flavobacteriia,2NUMS@237|Flavobacterium 976|Bacteroidetes I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_299975_1 425104.Ssed_3889 6.24e-104 316.0 COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,1RM86@1236|Gammaproteobacteria,2Q904@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM phosphate-selective porin O and P - - - - - - - - - - - - Porin_4,Porin_O_P k59_660632_1 1165841.SULAR_06208 1.08e-120 368.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2YMPF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_856300_1 1168034.FH5T_20985 3.44e-71 224.0 COG2430@1|root,COG2430@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF432 k59_790342_1 2340.JV46_15850 2.49e-11 64.3 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1J5GI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Mur_ligase_C,Mur_ligase_M k59_790342_2 1415778.JQMM01000001_gene866 2.72e-36 137.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1J5FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell division ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_235170_1 1547437.LL06_02265 2.07e-91 282.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,43IYG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain matB - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1019688_1 1121287.AUMU01000013_gene564 3.31e-67 210.0 COG0110@1|root,COG0110@2|Bacteria,4NH27@976|Bacteroidetes,1I7UE@117743|Flavobacteriia,3ZRVH@59732|Chryseobacterium 976|Bacteroidetes S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - Hexapep,Hexapep_2 k59_202309_1 326298.Suden_0543 9.35e-69 227.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2YMZZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Ribonuclease rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB k59_333782_1 1192034.CAP_2781 4.1e-14 78.6 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2WJNS@28221|Deltaproteobacteria,2YXZU@29|Myxococcales 28221|Deltaproteobacteria KLT Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_267255_1 1121012.AUKX01000042_gene2478 3.73e-53 173.0 COG0440@1|root,COG0440@2|Bacteria,4NIDK@976|Bacteroidetes,1HZAW@117743|Flavobacteriia,23HXB@178469|Arenibacter 976|Bacteroidetes E ACT domain - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_692753_1 244447.XP_008309177.1 4.36e-26 105.0 COG0434@1|root,2QUBS@2759|Eukaryota,38EZC@33154|Opisthokonta,3BES3@33208|Metazoa,3D0S4@33213|Bilateria,47ZQG@7711|Chordata,4905V@7742|Vertebrata,49RCN@7898|Actinopterygii 33208|Metazoa S Zgc 162297 - - - ko:K06971 - - - - ko00000 - - - BtpA k59_692753_2 1120953.AUBH01000001_gene945 1.18e-24 95.1 COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,1S8R5@1236|Gammaproteobacteria,467S6@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 13 family - - - - - - - - - - - - AMPK1_CBM,CBM_48 k59_986951_2 1165841.SULAR_01783 2.52e-44 152.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2YMPY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_823619_1 1249627.D779_1541 8.55e-96 296.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales 135613|Chromatiales CI TIGRFAM Oxaloacetate decarboxylase, alpha subunit - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_464583_1 1168034.FH5T_09635 3.8e-103 308.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FMPG@200643|Bacteroidia 976|Bacteroidetes T acetoacetate metabolism regulatory protein AtoC K07714 ntrX - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_888230_1 1052684.PPM_3217 6.57e-157 496.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_660663_1 459495.SPLC1_S550590 1.86e-57 192.0 COG0516@1|root,COG0516@2|Bacteria,1G1MX@1117|Cyanobacteria,1H94E@1150|Oscillatoriales 1117|Cyanobacteria F IMP dehydrogenase GMP reductase guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - IMPDH k59_202339_1 929558.SMGD1_2544 2.54e-44 150.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,42RPS@68525|delta/epsilon subdivisions,2YP4Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_202339_2 1537917.JU82_07270 2.71e-119 350.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2YMGD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_430583_1 1122604.JONR01000023_gene4186 2.07e-16 80.5 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1XCE4@135614|Xanthomonadales 135614|Xanthomonadales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_430583_2 105559.Nwat_0472 1.49e-15 75.9 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WXUC@135613|Chromatiales 135613|Chromatiales S ABC-type transport system involved in multi-copper enzyme maturation, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_1019705_1 1292035.H476_1671 3.62e-21 97.1 COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,25C37@186801|Clostridia,25UM5@186804|Peptostreptococcaceae 186801|Clostridia O SurA N-terminal domain prsA - 5.2.1.8 ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3,SurA_N_3 k59_1019705_2 469616.FMAG_02423 3.53e-35 127.0 COG1694@1|root,COG3956@2|Bacteria,378VW@32066|Fusobacteria 32066|Fusobacteria S MazG nucleotide pyrophosphohydrolase domain mazG - 3.6.1.66 ko:K02428,ko:K02499 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03036 - - - MazG k59_986965_1 85643.Tmz1t_0362 7.35e-160 472.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,2KUV3@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.3 ko:K07306 ko00920,map00920 - R09501 RC02555 ko00000,ko00001,ko01000,ko02000 5.A.3.3 - - Molybdopterin,Molydop_binding k59_627526_1 1123013.AUIC01000003_gene379 1.69e-27 115.0 COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria,4FN1Z@85023|Microbacteriaceae 201174|Actinobacteria NU Type II/IV secretion system protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_71846_1 1172190.M947_10580 3.03e-22 94.4 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2YMKF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M ABC-type transport system involved in lipoprotein release permease component lolC - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_71846_2 709032.Sulku_1478 5.08e-73 243.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2YMV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_202341_1 443143.GM18_4367 5.79e-77 238.0 2DBHY@1|root,2Z9DM@2|Bacteria,1RJGS@1224|Proteobacteria,42ZYY@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - HIRAN k59_757655_1 391615.ABSJ01000026_gene139 1.52e-18 90.1 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1J4CD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_627530_1 754436.JCM19237_5666 3.89e-48 167.0 COG1879@1|root,COG1879@2|Bacteria,1MWGU@1224|Proteobacteria,1RQ56@1236|Gammaproteobacteria,1XWRP@135623|Vibrionales 135623|Vibrionales G Periplasmic binding protein-like domain - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_725273_2 530564.Psta_1249 3.74e-07 51.6 COG3809@1|root,COG3809@2|Bacteria 2|Bacteria S Transcription factor zinc-finger - - - ko:K09981 - - - - ko00000 - - - zf-TFIIB k59_725273_3 933262.AXAM01000002_gene543 1.55e-37 136.0 COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,42P2H@68525|delta/epsilon subdivisions,2WJQM@28221|Deltaproteobacteria,2MI76@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM TraB family protein - - - - - - - - - - - - TraB k59_496979_1 1288494.EBAPG3_450 1.05e-77 244.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,371TS@32003|Nitrosomonadales 28216|Betaproteobacteria H RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_333825_1 439235.Dalk_1689 7.81e-54 191.0 COG2202@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,Response_reg k59_366197_1 666685.R2APBS1_1768 1.86e-90 281.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1X2YI@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_71860_1 1242969.ATCC51562_1645 1.26e-48 169.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,42MDQ@68525|delta/epsilon subdivisions,2YN45@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L RecT family - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_240207_6 566466.NOR53_282 4.49e-36 127.0 COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,1S9DS@1236|Gammaproteobacteria,1J6G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body flgB - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod k59_240207_7 1049564.TevJSym_aa01220 2.08e-65 202.0 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,1S653@1236|Gammaproteobacteria,1J6G3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar basal body rod FlgEFG protein C-terminal flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_240207_8 1049564.TevJSym_aa01230 7.08e-70 220.0 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,1RPZI@1236|Gammaproteobacteria,1J6FY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig k59_240207_9 396588.Tgr7_1220 5.52e-132 393.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,1RMWX@1236|Gammaproteobacteria,1WW6Q@135613|Chromatiales 135613|Chromatiales N basal body rod protein - - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_240207_10 472759.Nhal_2328 1.15e-103 307.0 COG4787@1|root,COG4787@2|Bacteria,1NZWQ@1224|Proteobacteria,1RNVX@1236|Gammaproteobacteria,1WWVR@135613|Chromatiales 135613|Chromatiales N TIGRFAM flagellar basal-body rod protein FlgF - - - ko:K02391 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_240207_11 1049564.TevJSym_aa01270 1.12e-134 387.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,1RMJ2@1236|Gammaproteobacteria,1J4WA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Belongs to the flagella basal body rod proteins family flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_240207_12 1049564.TevJSym_aa01280 1.89e-90 273.0 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,1S3XK@1236|Gammaproteobacteria,1J6EY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_240207_13 1049564.TevJSym_aa01290 6.1e-163 468.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,1RMRB@1236|Gammaproteobacteria,1J5BT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_240207_14 697282.Mettu_1238 8.84e-77 248.0 COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,1RPGY@1236|Gammaproteobacteria,1XEPD@135618|Methylococcales 135618|Methylococcales N Flagellar rod assembly protein muramidase FlgJ - - - ko:K02395 - - - - ko00000,ko02035 - - - Glucosaminidase,Rod-binding k59_240207_15 396588.Tgr7_1226 2.33e-134 415.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,1RMEA@1236|Gammaproteobacteria,1WW11@135613|Chromatiales 135613|Chromatiales N TIGRFAM Flagellar hook-associated protein, FlgK flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_240207_16 631362.Thi970DRAFT_02429 1.27e-48 177.0 COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,1WX4A@135613|Chromatiales 135613|Chromatiales N TIGRFAM Flagellar hook-associated protein 3 - - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_240207_17 1112217.PPL19_10327 2.37e-91 294.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,1RN0Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_240207_19 1132855.KB913035_gene1811 1.42e-11 75.1 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,2VHMK@28216|Betaproteobacteria,2KKHJ@206350|Nitrosomonadales 206350|Nitrosomonadales N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end - - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_240207_22 765912.Thimo_0512 7.06e-105 312.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales 135613|Chromatiales S Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_240207_23 765910.MARPU_15120 2.27e-232 651.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_666082_1 1150621.SMUL_0923 1.54e-107 325.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions 1224|Proteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_469262_1 537013.CLOSTMETH_02988 8.49e-27 113.0 COG1196@1|root,COG3250@1|root,COG1196@2|Bacteria,COG3250@2|Bacteria,1V1D9@1239|Firmicutes,24H7I@186801|Clostridia 2|Bacteria G Psort location sca1 - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF4988,F5_F8_type_C,FIVAR,Glyco_hydro_106,Glyco_hydro_2_N,RicinB_lectin_2 k59_793533_1 377629.TERTU_2487 7.07e-38 140.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,2PMGN@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria F Glutamine amidotransferase domain purF GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125 GATase_6,Pribosyltran k59_959134_1 348824.LPU83_3458 4.47e-23 97.8 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,4B9JA@82115|Rhizobiaceae 28211|Alphaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_1024395_2 243233.MCA2947 8.71e-14 68.2 COG0776@1|root,COG0776@2|Bacteria,1N71T@1224|Proteobacteria,1SSH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the bacterial histone-like protein family hupN - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_175704_1 1049564.TevJSym_as00050 5.1e-17 79.3 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,1J6UU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_77237_1 472759.Nhal_2479 9.01e-83 267.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1WXWN@135613|Chromatiales 135613|Chromatiales I PFAM 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_208229_1 338966.Ppro_2774 6.88e-53 177.0 COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,42PKE@68525|delta/epsilon subdivisions,2WSF9@28221|Deltaproteobacteria 28221|Deltaproteobacteria M MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_762840_1 742726.HMPREF9448_00670 4.39e-41 151.0 COG0438@1|root,COG0438@2|Bacteria,4NFMB@976|Bacteroidetes,2FMJE@200643|Bacteroidia,22XBH@171551|Porphyromonadaceae 976|Bacteroidetes M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4 k59_762840_2 1168034.FH5T_20670 1.41e-25 101.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis - - - ko:K03671,ko:K07152 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03029,ko03110 - - - AhpC-TSA,Glyco_hydro_8,Redoxin,SCO1-SenC,Thioredoxin,Thioredoxin_8 k59_208231_1 1121396.KB893070_gene1331 1.04e-88 265.0 COG4232@1|root,COG4232@2|Bacteria,1PK9S@1224|Proteobacteria,42PV0@68525|delta/epsilon subdivisions,2WJPK@28221|Deltaproteobacteria,2MIJ0@213118|Desulfobacterales 28221|Deltaproteobacteria CO PFAM Cytochrome C biogenesis protein transmembrane region dsbD - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_502907_2 1415780.JPOG01000001_gene72 1.05e-148 428.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1X7GN@135614|Xanthomonadales 135614|Xanthomonadales L Helix-turn-helix domain - - - - - - - - - - - - HTH_38,rve k59_697916_2 317025.Tcr_0778 3.88e-16 73.2 2E4RC@1|root,32ZJW@2|Bacteria,1N8RU@1224|Proteobacteria,1SCQJ@1236|Gammaproteobacteria,4635H@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_697916_4 1165841.SULAR_05413 5.04e-43 147.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2YM8T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the TrpC family trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_469274_1 1232437.KL662077_gene1870 2.46e-114 337.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MI7P@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Pyruvate flavodoxin ferredoxin oxidoreductase korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_992636_1 335543.Sfum_0478 1.06e-80 261.0 COG0031@1|root,COG0215@1|root,COG0031@2|Bacteria,COG0215@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,2MR3Q@213462|Syntrophobacterales 28221|Deltaproteobacteria J Pyridoxal-phosphate dependent enzyme cysM - 2.5.1.47,6.1.1.16 ko:K01738,ko:K01883,ko:K12339 ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00359,M00360 R00897,R03132,R03601,R03650,R04859 RC00020,RC00055,RC00523,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,PALP,tRNA-synt_1e k59_762854_1 1121918.ARWE01000001_gene3366 2.68e-141 432.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,43U3A@69541|Desulfuromonadales 28221|Deltaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding k59_793553_2 228410.NE1751 9.87e-07 50.4 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,2VVPQ@28216|Betaproteobacteria,37394@32003|Nitrosomonadales 28216|Betaproteobacteria U Type II transport protein GspH fimT - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_600423_2 572544.Ilyop_0664 0.0 943.0 COG0751@1|root,COG0751@2|Bacteria,378Q2@32066|Fusobacteria 32066|Fusobacteria J glycyl-tRNA synthetase beta glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_600423_3 572544.Ilyop_0663 1.61e-193 538.0 COG0752@1|root,COG0752@2|Bacteria,3786U@32066|Fusobacteria 32066|Fusobacteria J Glycyl-tRNA synthetase alpha glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_600423_4 469616.FMAG_02085 8.44e-50 164.0 COG0597@1|root,COG0597@2|Bacteria,37AGM@32066|Fusobacteria 32066|Fusobacteria M This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_600423_5 572544.Ilyop_0661 5.75e-194 567.0 COG0060@1|root,COG0060@2|Bacteria,3788C@32066|Fusobacteria 32066|Fusobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_371498_1 1123059.KB823013_gene670 1.39e-23 104.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,43W9V@69657|Hyphomonadaceae 28211|Alphaproteobacteria G PFAM glycoside hydrolase, family 3 domain protein - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C k59_992648_1 1381123.AYOD01000064_gene1523 1.83e-87 268.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria,43H8Y@69277|Phyllobacteriaceae 28211|Alphaproteobacteria H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016874,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_339653_3 1537917.JU82_05700 3.27e-195 545.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,42MFN@68525|delta/epsilon subdivisions,2YNDN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_403486_1 1050201.KB913034_gene761 1.25e-30 121.0 COG0037@1|root,COG0037@2|Bacteria,1TQ0Y@1239|Firmicutes,3VP9V@526524|Erysipelotrichia 526524|Erysipelotrichia H Belongs to the TtcA family - - - - - - - - - - - - ATP_bind_3 k59_110051_1 573061.Clocel_2560 2.31e-28 107.0 COG3339@1|root,COG3339@2|Bacteria,1VB9N@1239|Firmicutes,24NG4@186801|Clostridia,36M3B@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_110051_2 1168034.FH5T_06075 1.35e-36 132.0 COG0042@1|root,COG0042@2|Bacteria,4NEN4@976|Bacteroidetes,2FM9Z@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - - - - - - - - - - Dus k59_1024427_1 1150621.SMUL_1638 3.53e-100 306.0 COG3658@1|root,COG3658@2|Bacteria,1REFV@1224|Proteobacteria,42Q0G@68525|delta/epsilon subdivisions,2YN98@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome - - - - - - - - - - - - DHC,Ni_hydr_CYTB k59_435687_1 1286631.X805_11510 3.85e-16 73.2 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VSPR@28216|Betaproteobacteria,1KMNZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III nosC - - - - - - - - - - - Cytochrome_CBB3 k59_435687_2 1158762.KB898042_gene915 1.59e-54 175.0 2DX2X@1|root,32V2M@2|Bacteria,1MZZC@1224|Proteobacteria,1S4WN@1236|Gammaproteobacteria,1WYAX@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_435687_3 1206777.B195_19406 4.99e-10 58.2 COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,1Z7T9@136849|Pseudomonas syringae group 1236|Gammaproteobacteria J thiopurine S-methyltransferase activity tpm GO:0003674,GO:0003824,GO:0008119,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008757,GO:0010035,GO:0010038,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0046690,GO:0050896 2.1.1.67 ko:K00569 ko00983,map00983 - R08236,R08239,R08246 RC00003,RC00980,RC02277 ko00000,ko00001,ko01000 - - - TPMT k59_762870_1 56110.Oscil6304_6055 8.4e-37 138.0 COG3335@1|root,COG3335@2|Bacteria,1G4FA@1117|Cyanobacteria,1HBRR@1150|Oscillatoriales 1117|Cyanobacteria L K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_894068_1 1250006.JHZZ01000001_gene1120 7.78e-28 110.0 COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1HY74@117743|Flavobacteriia,3VXHN@52959|Polaribacter 976|Bacteroidetes EGP Sugar (and other) transporter xylE - - ko:K02100,ko:K03444,ko:K08138 - - - - ko00000,ko02000 2.A.1.1,2.A.1.1.2,2.A.1.1.3 - - Sugar_tr k59_894068_2 1288963.ADIS_4244 1.23e-61 211.0 COG0457@1|root,COG0457@2|Bacteria,4NIBU@976|Bacteroidetes,47P3K@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF5107) - - - - - - - - - - - - DUF5107,TPR_16,TPR_6,TPR_8 k59_762873_1 1168034.FH5T_12940 1.77e-107 317.0 COG0202@1|root,COG0202@2|Bacteria,4NE8W@976|Bacteroidetes,2FM4P@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_240254_2 1049564.TevJSym_as00410 2.26e-21 88.6 2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,1SD8N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2782) - - - - - - - - - - - - DUF2782 k59_175752_1 589865.DaAHT2_2388 4.41e-08 53.5 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2MJ44@213118|Desulfobacterales 28221|Deltaproteobacteria NU PFAM type II secretion system - - - ko:K02653,ko:K12278 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_175752_2 933262.AXAM01000018_gene976 1.35e-43 156.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42NEU@68525|delta/epsilon subdivisions,2WM5E@28221|Deltaproteobacteria,2MMZP@213118|Desulfobacterales 28221|Deltaproteobacteria KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat k59_633090_1 1000565.METUNv1_01303 6.4e-47 171.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV5K@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_535568_1 1280692.AUJL01000008_gene2513 2.95e-68 214.0 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,24DGQ@186801|Clostridia,36E9G@31979|Clostridiaceae 186801|Clostridia L PFAM Integrase catalytic region - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_894076_2 1122604.JONR01000022_gene649 8.13e-125 369.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XCIJ@135614|Xanthomonadales 135614|Xanthomonadales J Histidyl-tRNA synthetase - - - - - - - - - - - - HGTP_anticodon,tRNA-synt_His k59_503777_1 1168034.FH5T_09330 2.33e-94 296.0 COG0557@1|root,COG0557@2|Bacteria,4NE7T@976|Bacteroidetes,2FMM6@200643|Bacteroidia 976|Bacteroidetes J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573,ko:K12585 ko03018,map03018 M00391 - - ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_176556_1 1191523.MROS_1712 2.43e-52 183.0 COG3459@1|root,COG3459@2|Bacteria 2|Bacteria G carbohydrate binding cbpA - 2.4.1.20 ko:K00702 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000 - GT36 - Glyco_hydro_36,Glyco_transf_36 k59_176556_2 278957.ABEA03000160_gene9 1.95e-07 53.9 COG0395@1|root,COG0395@2|Bacteria,46YDG@74201|Verrucomicrobia,3K9CV@414999|Opitutae 414999|Opitutae G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_77831_1 1168034.FH5T_14935 1.25e-95 300.0 COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,2FWMX@200643|Bacteroidia 976|Bacteroidetes E Amino acid permease - - - - - - - - - - - - AA_permease k59_730461_2 1196322.A370_01650 4.27e-10 57.0 2ED1S@1|root,336YP@2|Bacteria,1VJRI@1239|Firmicutes,24UCF@186801|Clostridia,36T2P@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_601233_1 224308.BSU17210 1.28e-126 416.0 COG1020@1|root,COG1028@1|root,COG3321@1|root,COG4221@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HTBC@91061|Bacilli,1ZS7J@1386|Bacillus 91061|Bacilli IQ polyketide synthase - - - ko:K13611,ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_240946_1 1168034.FH5T_06120 1.01e-43 160.0 COG0760@1|root,COG0760@2|Bacteria,4NDZZ@976|Bacteroidetes,2FN8C@200643|Bacteroidia 976|Bacteroidetes O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_2 k59_305551_2 1168034.FH5T_12760 6.94e-81 254.0 COG0373@1|root,COG0373@2|Bacteria,4NFTY@976|Bacteroidetes,2FT24@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_763688_1 316275.VSAL_I0750 1.56e-23 100.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XTXA@135623|Vibrionales 135623|Vibrionales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_763688_2 553385.JEMF01000010_gene2346 4.46e-22 94.4 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1XJCR@135619|Oceanospirillales 135619|Oceanospirillales S beta-lactamase - - - - - - - - - - - - Lactamase_B_2 k59_734734_1 1123514.KB905899_gene1224 3.71e-69 227.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria 1236|Gammaproteobacteria M protein conserved in bacteria - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_148562_1 290397.Adeh_3200 3.85e-20 96.3 COG3303@1|root,COG3303@2|Bacteria,1NT38@1224|Proteobacteria,43CCP@68525|delta/epsilon subdivisions,2X7NK@28221|Deltaproteobacteria,2YZY2@29|Myxococcales 28221|Deltaproteobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - - k59_734735_1 387093.SUN_1244 4.89e-97 289.0 COG3023@1|root,COG3023@2|Bacteria,1PV6E@1224|Proteobacteria,42ZQH@68525|delta/epsilon subdivisions,2YRNB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2 k59_181194_1 713586.KB900536_gene245 1.84e-116 338.0 COG0599@1|root,COG2146@1|root,COG0599@2|Bacteria,COG2146@2|Bacteria,1RCCG@1224|Proteobacteria 1224|Proteobacteria P Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD,Rieske k59_213679_1 929558.SMGD1_0008 2.33e-25 111.0 COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2YMXW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cytochrome c biogenesis protein ccsBA - - - - - - - - - - - Cytochrom_C_asm,ResB k59_276546_1 1232437.KL662023_gene910 3.77e-32 122.0 COG0210@1|root,COG0210@2|Bacteria,1R4PV@1224|Proteobacteria,42RIG@68525|delta/epsilon subdivisions,2WTU2@28221|Deltaproteobacteria,2MN3C@213118|Desulfobacterales 28221|Deltaproteobacteria L UvrD/REP helicase N-terminal domain - - - - - - - - - - - - UvrD-helicase,UvrD_C k59_703248_1 1112209.AHVZ01000026_gene1455 2.01e-20 93.6 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,3NIKK@468|Moraxellaceae 1236|Gammaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_376323_1 713586.KB900536_gene1555 2.35e-125 368.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M20A family. ArgE subfamily - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_899272_1 1227352.C173_17291 1.23e-26 109.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,271UU@186822|Paenibacillaceae 91061|Bacilli J tRNA synthetases class II (A) - - - - - - - - - - - - tRNA-synt_2c,tRNA_SAD k59_899272_2 456442.Mboo_1257 1.06e-33 135.0 COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2N91H@224756|Methanomicrobia 224756|Methanomicrobia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - - - - - - - - - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_605846_2 96561.Dole_1655 4.31e-39 132.0 COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,42WQ3@68525|delta/epsilon subdivisions 1224|Proteobacteria L PFAM Excinuclease ABC C subunit domain protein - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_572704_2 375286.mma_1307 7.92e-59 191.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,472DU@75682|Oxalobacteraceae 28216|Betaproteobacteria P Phosphate transporter family pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_47481_1 56780.SYN_03249 2.05e-90 278.0 COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,42TEG@68525|delta/epsilon subdivisions,2WPXW@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_734753_1 272558.10174842 2.05e-98 308.0 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,4HA5R@91061|Bacilli,1ZBRR@1386|Bacillus 91061|Bacilli G Alpha-galactosidase aga - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase k59_344945_2 1165841.SULAR_07950 8.31e-63 194.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2YPXD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_408613_1 1185766.DL1_11775 1.57e-30 110.0 COG2929@1|root,COG2929@2|Bacteria,1MZKJ@1224|Proteobacteria,2UDS0@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_114975_1 1168034.FH5T_08860 3.34e-51 168.0 COG1309@1|root,COG1309@2|Bacteria,4NQ99@976|Bacteroidetes 976|Bacteroidetes K Transcriptional regulator (TetR family) - - - - - - - - - - - - TetR_N k59_114975_2 1168034.FH5T_08855 1.16e-29 117.0 COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes,2FM4A@200643|Bacteroidia 976|Bacteroidetes MU Psort location OuterMembrane, score - - - - - - - - - - - - OEP k59_797656_1 452637.Oter_2711 8.63e-13 67.8 COG1950@1|root,COG1950@2|Bacteria,46W1Z@74201|Verrucomicrobia,3K8BW@414999|Opitutae 414999|Opitutae S Mycobacterial 4 TMS phage holin, superfamily IV - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_671405_1 387092.NIS_0303 1.88e-27 108.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2YMKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_671405_2 387093.SUN_2218 1.07e-42 152.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2YNBN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_638292_1 572544.Ilyop_0001 3.45e-260 733.0 28HN5@1|root,2Z7WI@2|Bacteria,37876@32066|Fusobacteria 32066|Fusobacteria S Replication initiator protein A - - - - - - - - - - - - RPA k59_408618_1 1172190.M947_08250 3.14e-108 324.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2YMQ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_408618_2 749222.Nitsa_1124 3.34e-67 225.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2YM8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_605862_1 863239.AFIZ01000010_gene1289 1.17e-10 64.3 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,22JI3@1653|Corynebacteriaceae 201174|Actinobacteria IQ Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II fadD4 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_734770_1 1168034.FH5T_21940 2.81e-23 95.1 COG0020@1|root,COG0020@2|Bacteria,4NF2B@976|Bacteroidetes,2FMM4@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_734770_2 1168034.FH5T_21945 1.6e-61 197.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - - - - - - - - - - - k59_997861_1 1484158.PSNIH1_12060 4.11e-36 133.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,3VYMB@53335|Pantoea 1236|Gammaproteobacteria S High frequency lysogenization protein HflD homolog hflD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562 - ko:K07153 - - - - ko00000 - - - DUF489 k59_213726_1 387092.NIS_0515 3.81e-80 248.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42MFD@68525|delta/epsilon subdivisions,2YN54@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K NAD-dependent protein deacetylase, SIR2 family - - - - - - - - - - - - SIR2 k59_114994_1 411473.RUMCAL_03371 6.41e-06 53.9 arCOG08054@1|root,2Z8AD@2|Bacteria,1TQ1J@1239|Firmicutes,2485U@186801|Clostridia,3WH6F@541000|Ruminococcaceae 186801|Clostridia S Carbohydrate-binding domain-containing protein Cthe_2159 - - - - - - - - - - - - Cthe_2159 k59_572737_1 709032.Sulku_0886 2.25e-232 649.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2YMF3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_440896_2 886379.AEWI01000037_gene2971 2.74e-58 194.0 COG1774@1|root,COG1774@2|Bacteria,4NENX@976|Bacteroidetes,2FNYP@200643|Bacteroidia,3XJUN@558415|Marinilabiliaceae 976|Bacteroidetes S PSP1 C-terminal conserved region yaaT - - - - - - - - - - - PSP1 k59_114998_1 177437.HRM2_11630 5.4e-23 97.1 28RRT@1|root,33K0J@2|Bacteria,1NKEP@1224|Proteobacteria,430T6@68525|delta/epsilon subdivisions,2WW1A@28221|Deltaproteobacteria,2MNQS@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF3187) - - - - - - - - - - - - DUF3187 k59_114998_2 1396418.BATQ01000127_gene2551 7.63e-09 58.2 COG1572@1|root,COG1572@2|Bacteria,46Z39@74201|Verrucomicrobia,2IW8C@203494|Verrucomicrobiae 203494|Verrucomicrobiae NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - - k59_671434_1 1537917.JU82_05665 1.83e-11 62.4 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2YMD4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulatory protein yebC - - - - - - - - - - - Transcrip_reg k59_671444_1 195250.CM001776_gene949 1.06e-35 140.0 COG0358@1|root,COG0358@2|Bacteria 2|Bacteria L DNA primase activity - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_310091_1 519989.ECTPHS_07331 2.36e-124 386.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_704024_1 1254432.SCE1572_06645 2.9e-15 81.6 COG3209@1|root,COG4223@1|root,COG3209@2|Bacteria,COG4223@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Rhs family - - - - - - - - - - - - AHH,RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_246151_1 886379.AEWI01000001_gene1678 2.84e-17 82.4 COG2603@1|root,COG2603@2|Bacteria,4NH7W@976|Bacteroidetes,2FPYI@200643|Bacteroidia,3XITS@558415|Marinilabiliaceae 976|Bacteroidetes S Rhodanese-like domain - - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_246151_2 880073.Calab_1785 1.03e-44 161.0 COG0709@1|root,COG1104@1|root,COG0709@2|Bacteria,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine selD - 2.7.9.3,2.8.1.7 ko:K01008,ko:K04487 ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122 - R03595,R07460,R11528,R11529 RC00002,RC01789,RC02313,RC02878 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - AIRS,AIRS_C,Aminotran_5 k59_704030_1 861450.HMPREF0080_00112 6.22e-43 153.0 COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,4H28V@909932|Negativicutes 909932|Negativicutes F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_639172_1 1122599.AUGR01000015_gene2633 4.34e-85 259.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,1XI6A@135619|Oceanospirillales 135619|Oceanospirillales E ABC transporter permease - - - ko:K11070,ko:K11074 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - - BPD_transp_1 k59_12266_1 96561.Dole_0113 4.4e-126 375.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42YF1@68525|delta/epsilon subdivisions,2WUJ5@28221|Deltaproteobacteria,2MN3T@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_798524_1 713586.KB900536_gene450 2.32e-82 255.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1WWTQ@135613|Chromatiales 135613|Chromatiales E PFAM aminotransferase, class I - - - - - - - - - - - - Aminotran_1_2 k59_310857_1 502025.Hoch_6172 3.11e-16 87.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - ko:K07497 - - - - ko00000 - - - Mu-transpos_C,rve k59_573590_1 1168034.FH5T_17495 1.44e-05 46.2 COG3299@1|root,COG3299@2|Bacteria,4NF69@976|Bacteroidetes,2FN8K@200643|Bacteroidia 976|Bacteroidetes S homolog of phage Mu protein gp47 - - - - - - - - - - - - Baseplate_J k59_573590_2 1168034.FH5T_17490 1.89e-72 219.0 COG3628@1|root,COG3628@2|Bacteria,4NSKN@976|Bacteroidetes,2FSRN@200643|Bacteroidia 976|Bacteroidetes S Gene 25-like lysozyme - - - ko:K06903 - - - - ko00000 - - - GPW_gp25 k59_48357_1 156889.Mmc1_1749 3.35e-125 373.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_182027_1 765912.Thimo_0714 1.2e-57 184.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1S237@1236|Gammaproteobacteria,1WWYK@135613|Chromatiales 135613|Chromatiales P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_12276_1 1049564.TevJSym_bc00300 1.48e-89 273.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Hydrogenase formation hypA family hypD GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - ko:K04654 - - - - ko00000 - - - HypD k59_965417_1 396588.Tgr7_0497 4.86e-48 170.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales 135613|Chromatiales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_246159_1 1045858.Bint_1373 6.95e-26 105.0 COG0655@1|root,COG0655@2|Bacteria 2|Bacteria S NAD(P)H dehydrogenase (quinone) activity - - - - - - - - - - - - FMN_red k59_246159_2 641107.CDLVIII_5286 3.83e-133 389.0 COG0388@1|root,COG0388@2|Bacteria,1TQR9@1239|Firmicutes,24BFR@186801|Clostridia,36HSP@31979|Clostridiaceae 186801|Clostridia S Carbon-nitrogen hydrolase - - 3.5.5.1 ko:K01501,ko:K18282 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00152,R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811,RC03209,RC03210 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_246159_3 656519.Halsa_0170 1.88e-173 505.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia 186801|Clostridia G import. Responsible for energy coupling to the transport system - - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran k59_900085_1 1168034.FH5T_17860 1.52e-152 436.0 28V9W@1|root,2ZHCT@2|Bacteria,4NMQ0@976|Bacteroidetes,2FTU3@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_900085_2 1121104.AQXH01000001_gene1940 6.82e-22 90.5 COG1028@1|root,COG1028@2|Bacteria,4NGAH@976|Bacteroidetes,1ISUI@117747|Sphingobacteriia 976|Bacteroidetes IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short,adh_short_C2 k59_866807_1 748247.AZKH_0390 1.52e-49 172.0 COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,2VPP2@28216|Betaproteobacteria,2KYGM@206389|Rhodocyclales 206389|Rhodocyclales E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_246167_1 1211115.ALIQ01000219_gene1426 1.06e-17 87.4 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,3NC6C@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_82839_1 396588.Tgr7_2289 2.13e-83 256.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales 135613|Chromatiales P PFAM CBS domain - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_639200_1 1168034.FH5T_03590 1.36e-88 281.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolase family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_12289_1 748658.KB907314_gene139 1.9e-45 158.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales 135613|Chromatiales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_769226_1 1168034.FH5T_04745 6.71e-167 476.0 COG1160@1|root,COG1160@2|Bacteria,4NE2J@976|Bacteroidetes,2FN63@200643|Bacteroidia 976|Bacteroidetes S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_965441_1 1121396.KB893051_gene3434 1.49e-14 72.8 COG0747@1|root,COG0747@2|Bacteria,1QTPR@1224|Proteobacteria,4347B@68525|delta/epsilon subdivisions,2X1YT@28221|Deltaproteobacteria,2MNI3@213118|Desulfobacterales 28221|Deltaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - SBP_bac_5 k59_965441_2 1463861.JNXE01000002_gene6546 7.82e-17 82.8 COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,2GIXV@201174|Actinobacteria 201174|Actinobacteria EP Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_541549_1 1121033.AUCF01000032_gene2627 2.77e-108 330.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_998687_1 1107311.Q767_05335 7.23e-08 65.9 COG5295@1|root,COG5295@2|Bacteria,4NN21@976|Bacteroidetes,1I1UJ@117743|Flavobacteriia,2NUBX@237|Flavobacterium 976|Bacteroidetes UW arginyl-trna synthetase - - - - - - - - - - - - - k59_277364_1 765911.Thivi_2455 4.59e-70 234.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1WXVP@135613|Chromatiales 135613|Chromatiales P PFAM von Willebrand factor type A - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - VWA,VWA_2 k59_409543_2 869213.JCM21142_93557 2.64e-19 82.4 COG1846@1|root,COG1846@2|Bacteria,4NRNH@976|Bacteroidetes 976|Bacteroidetes K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k59_246193_1 1034769.KB910518_gene4676 6.29e-49 171.0 COG1835@1|root,COG1835@2|Bacteria,1UZQR@1239|Firmicutes,4HTG8@91061|Bacilli 91061|Bacilli I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_277376_1 1395513.P343_04440 8.22e-06 54.7 COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,4H9Q3@91061|Bacilli,26NDY@186821|Sporolactobacillaceae 91061|Bacilli L Putative exonuclease SbcCD, C subunit sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,AAA_29,SbcCD_C k59_798587_1 1172190.M947_09770 6.23e-84 250.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,42QU1@68525|delta/epsilon subdivisions,2YNVF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP1038 DHquinase_II k59_798587_2 563040.Saut_0712 3.49e-60 191.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2YPJ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_798587_3 709032.Sulku_0475 2.11e-63 208.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,42NBF@68525|delta/epsilon subdivisions,2YN28@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar biosynthesis flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_441684_1 926550.CLDAP_01770 3.7e-46 164.0 COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi 200795|Chloroflexi C Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_672321_1 765910.MARPU_12575 7.4e-49 168.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1WXHI@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_345844_1 762376.AXYL_02006 5.88e-22 100.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,3T2GX@506|Alcaligenaceae 28216|Betaproteobacteria L ATP-dependent helicase hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_351806_1 1353529.M899_0937 7.43e-81 245.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2MTMU@213481|Bdellovibrionales,2WN6W@28221|Deltaproteobacteria 213481|Bdellovibrionales O C-terminal domain of 1-Cys peroxiredoxin ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_351806_2 877424.ATWC01000010_gene436 6.82e-54 185.0 COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,27IYX@186928|unclassified Lachnospiraceae 186801|Clostridia J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_383194_1 1089553.Tph_c18560 1.63e-52 179.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,42EZ0@68295|Thermoanaerobacterales 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_579429_1 384676.PSEEN0083 2.92e-05 47.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain pleD - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_579429_2 694431.DESACE_05030 6.51e-28 104.0 COG1342@1|root,COG1342@2|Bacteria,1N80T@1224|Proteobacteria,42WNR@68525|delta/epsilon subdivisions,2X5QD@28221|Deltaproteobacteria,2M7B9@213113|Desulfurellales 28221|Deltaproteobacteria S Protein of unknown function DUF134 - - - - - - - - - - - - DUF134 k59_415415_1 65093.PCC7418_2870 4.12e-83 268.0 COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria 1117|Cyanobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase xfp - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_678560_1 935836.JAEL01000012_gene5111 1.51e-06 54.7 COG0596@1|root,COG0596@2|Bacteria,1UZP1@1239|Firmicutes,4HBKV@91061|Bacilli,1ZE0T@1386|Bacillus 91061|Bacilli S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_841700_1 1168034.FH5T_12990 2.44e-116 354.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,2FMQP@200643|Bacteroidia 976|Bacteroidetes G Alpha-1,2-mannosidase - - - - - - - - - - - - Glyco_hydro_92 k59_284468_1 861299.J421_3729 4.98e-22 95.9 COG0591@1|root,COG0591@2|Bacteria,1ZUAP@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Sodium:solute symporter family - - - ko:K14392 - - - - ko00000,ko02000 2.A.21.1 - - SSF k59_284468_2 518766.Rmar_0281 2.15e-08 58.9 COG1629@1|root,COG4771@2|Bacteria,4NTQD@976|Bacteroidetes 976|Bacteroidetes P TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_646564_1 1255043.TVNIR_2146 2.35e-24 94.7 2BECK@1|root,3283Q@2|Bacteria,1RKSC@1224|Proteobacteria,1T14S@1236|Gammaproteobacteria,1X2MY@135613|Chromatiales 135613|Chromatiales S T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k59_646564_2 498211.CJA_3054 4.14e-86 267.0 COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,1RQUU@1236|Gammaproteobacteria 1236|Gammaproteobacteria M tail sheath protein - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_384679_1 493475.GARC_4554 1.67e-13 71.6 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,466HH@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_384679_2 1454004.AW11_02007 9.15e-59 202.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KQ5Y@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria V MMPL family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_123182_1 349124.Hhal_1786 1.74e-38 142.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1WWQT@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_221629_1 1168034.FH5T_21765 5.2e-117 343.0 COG1466@1|root,COG1466@2|Bacteria,4NEIB@976|Bacteroidetes,2FNY6@200643|Bacteroidia 976|Bacteroidetes L DNA polymerase III, delta' subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta k59_711356_2 387093.SUN_1433 7.54e-90 279.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1R5RS@1224|Proteobacteria,42M3K@68525|delta/epsilon subdivisions,2YN6E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM biotin lipoyl attachment domain-containing protein pycB - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_253466_1 243159.AFE_2947 7.66e-06 53.1 COG1651@1|root,COG1651@2|Bacteria,1NEFD@1224|Proteobacteria,1SMAT@1236|Gammaproteobacteria,2NCV6@225057|Acidithiobacillales 225057|Acidithiobacillales O Thioredoxin-like domain - - - ko:K03805 - - - - ko00000,ko03110 - - - Thioredoxin_2 k59_221633_1 314278.NB231_10523 5.77e-27 107.0 COG1980@1|root,COG1980@2|Bacteria,1MXM7@1224|Proteobacteria,1SKUG@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) - - 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 - - - FBPase_3 k59_221633_2 706587.Desti_3042 1.52e-52 171.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,42PP3@68525|delta/epsilon subdivisions,2X227@28221|Deltaproteobacteria,2MQQ2@213462|Syntrophobacterales 28221|Deltaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_384691_1 226186.BT_2712 1.95e-07 50.8 COG0097@1|root,COG0097@2|Bacteria,4NGJM@976|Bacteroidetes,2FNEG@200643|Bacteroidia,4AKP6@815|Bacteroidaceae 976|Bacteroidetes J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_384691_2 1168034.FH5T_12895 1.8e-57 180.0 COG0256@1|root,COG0256@2|Bacteria,4NQAS@976|Bacteroidetes,2FSHX@200643|Bacteroidia 976|Bacteroidetes J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_384691_3 1168034.FH5T_12900 1.09e-07 51.2 COG0098@1|root,COG0098@2|Bacteria,4NG1Z@976|Bacteroidetes,2FMI8@200643|Bacteroidia 976|Bacteroidetes J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_481595_1 243231.GSU1292 7.41e-40 146.0 COG4585@1|root,COG4585@2|Bacteria,1QXNA@1224|Proteobacteria,43C4A@68525|delta/epsilon subdivisions,2WPFP@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 k59_416417_1 1172190.M947_02105 1.9e-103 322.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2YMP3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Highly conserved protein containing a thioredoxin domain - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_284478_1 866536.Belba_1163 1.21e-58 194.0 COG3385@1|root,COG3385@2|Bacteria,4NJC6@976|Bacteroidetes,47UVE@768503|Cytophagia 976|Bacteroidetes L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_613972_1 1487921.DP68_18235 2.33e-43 155.0 COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,36EMK@31979|Clostridiaceae 186801|Clostridia E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_317862_1 617140.AJZE01000072_gene850 1.11e-101 315.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1Y2CG@135623|Vibrionales 135623|Vibrionales C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_55455_2 1165841.SULAR_08734 1.4e-46 154.0 COG2236@1|root,COG2236@2|Bacteria,1Q1HY@1224|Proteobacteria,42TR4@68525|delta/epsilon subdivisions,2YP9B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F phosphoribosyltransferase gpt - 2.4.2.22 ko:K00769 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01229,R02142 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_1005802_1 345201.RNC_IIV3 4.42e-124 362.0 4QDVH@10239|Viruses,4QXBB@35237|dsDNA viruses no RNA stage 10239|Viruses S ribonuclease III activity - - - - - - - - - - - - - k59_940452_1 1168034.FH5T_13600 6.47e-243 671.0 COG0538@1|root,COG0538@2|Bacteria,4NDY2@976|Bacteroidetes,2FQZ2@200643|Bacteroidia 976|Bacteroidetes C Belongs to the isocitrate and isopropylmalate dehydrogenases family icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_940452_2 1123008.KB905692_gene198 3.54e-20 89.4 COG0538@1|root,COG0538@2|Bacteria,4PKW6@976|Bacteroidetes,2FKYF@200643|Bacteroidia,22WNM@171551|Porphyromonadaceae 976|Bacteroidetes C Isocitrate/isopropylmalate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_646589_1 380358.XALC_3171 1.8e-73 238.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1X497@135614|Xanthomonadales 135614|Xanthomonadales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_284482_1 491915.Aflv_1528 7.21e-47 161.0 COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,4HAV5@91061|Bacilli,21V70@150247|Anoxybacillus 91061|Bacilli S YmdB-like protein ymdB GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 - ko:K02029,ko:K02030,ko:K09769 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - YmdB k59_284482_2 1121920.AUAU01000033_gene2764 1.05e-54 186.0 COG1418@1|root,COG1418@2|Bacteria 2|Bacteria S mRNA catabolic process rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_613981_1 1144343.PMI41_03819 2.6e-35 132.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,43IGK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_841730_1 105559.Nwat_1136 8.06e-70 227.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales 135613|Chromatiales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_907228_1 385682.AFSL01000008_gene2516 1.45e-17 75.9 COG0261@1|root,COG0261@2|Bacteria,4NSHE@976|Bacteroidetes,2G2BE@200643|Bacteroidia,3XK8X@558415|Marinilabiliaceae 976|Bacteroidetes J Ribosomal prokaryotic L21 protein rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - HHH_5,Rho_N,Ribosomal_L21p k59_907228_2 1408473.JHXO01000010_gene3583 8.69e-49 156.0 COG0211@1|root,COG0211@2|Bacteria,4NS7T@976|Bacteroidetes,2FTXU@200643|Bacteroidia 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_742571_1 56110.Oscil6304_3538 1.12e-80 262.0 COG5421@1|root,COG5421@2|Bacteria,1G4EU@1117|Cyanobacteria,1H9I9@1150|Oscillatoriales 1117|Cyanobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_481604_1 387093.SUN_2194 6.59e-68 230.0 COG4773@1|root,COG4773@2|Bacteria,1PP2I@1224|Proteobacteria,42WFP@68525|delta/epsilon subdivisions,2YQM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD k59_907230_1 1249480.B649_11065 5.3e-109 328.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2YN87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Abc transporter nikZ - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_841734_1 1121406.JAEX01000001_gene401 6.81e-08 58.9 COG1092@1|root,COG1092@2|Bacteria,1Q08C@1224|Proteobacteria,42RRW@68525|delta/epsilon subdivisions,2WNY5@28221|Deltaproteobacteria,2MAYH@213115|Desulfovibrionales 28221|Deltaproteobacteria J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_742575_1 1434325.AZQN01000001_gene396 0.000419 49.3 COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,47JS4@768503|Cytophagia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_21,TPR_6,TPR_8 k59_90470_1 382464.ABSI01000013_gene1575 4.94e-119 360.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4,Peptidase_S15 k59_189390_1 1384056.N787_13360 1.45e-11 68.2 COG0823@1|root,COG0823@2|Bacteria,1MZ1T@1224|Proteobacteria,1RMNE@1236|Gammaproteobacteria,1X6J1@135614|Xanthomonadales 135614|Xanthomonadales U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_1005819_1 1168034.FH5T_21240 1.92e-48 159.0 COG0724@1|root,COG0724@2|Bacteria,4NT1J@976|Bacteroidetes,2FSSS@200643|Bacteroidia 976|Bacteroidetes S RNA recognition motif - - - - - - - - - - - - RRM_1 k59_613992_1 1168034.FH5T_00370 1.36e-12 67.0 COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes,2FN8H@200643|Bacteroidia 976|Bacteroidetes J SAM-dependent methyltransferase rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_613992_2 1168034.FH5T_00375 9.95e-94 278.0 COG0349@1|root,COG0349@2|Bacteria,4NP3B@976|Bacteroidetes,2FN2U@200643|Bacteroidia 976|Bacteroidetes L 3'-5' exonuclease rnd - - - - - - - - - - - DNA_pol_A_exo1 k59_613992_3 1168034.FH5T_00380 2.65e-05 45.4 2AIA7@1|root,318R1@2|Bacteria,4NQPK@976|Bacteroidetes,2FPYF@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF5063 k59_1037575_1 243233.MCA1476 2.46e-127 380.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1XEKR@135618|Methylococcales 135618|Methylococcales F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_711399_1 96561.Dole_0566 4.33e-115 341.0 COG0004@1|root,COG0004@2|Bacteria,1R50W@1224|Proteobacteria,42PKR@68525|delta/epsilon subdivisions,2WM8P@28221|Deltaproteobacteria,2MII5@213118|Desulfobacterales 28221|Deltaproteobacteria P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_517077_3 1121918.ARWE01000001_gene1241 8.31e-23 101.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,42MBW@68525|delta/epsilon subdivisions,2WK2Z@28221|Deltaproteobacteria,43SWT@69541|Desulfuromonadales 28221|Deltaproteobacteria K PFAM ribonuclease BN - - - ko:K07058 - - - - ko00000 - - - Rrf2,Virul_fac_BrkB k59_874153_1 1410620.SHLA_33c000510 3.75e-34 135.0 COG4530@1|root,COG5002@1|root,COG4530@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TVYB@28211|Alphaproteobacteria,4B9QH@82115|Rhizobiaceae 28211|Alphaproteobacteria T Histidine kinase pdhS - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_8,PAS_9 k59_940481_1 1249480.B649_00825 7.36e-79 235.0 COG0096@1|root,COG0096@2|Bacteria,1N3R7@1224|Proteobacteria,43AC0@68525|delta/epsilon subdivisions,2YP6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_449362_1 335543.Sfum_1278 1.45e-77 249.0 COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MR2F@213462|Syntrophobacterales 28221|Deltaproteobacteria C acetyl-CoA - - - ko:K18122,ko:K18288 ko00650,ko00660,ko01100,ko01200,map00650,map00660,map01100,map01200 - R02407,R05336,R10600 RC00012,RC00014 ko00000,ko00001,ko01000 - - iAF987.Gmet_2142,iAF987.Gmet_3304 AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3 k59_776576_1 765912.Thimo_0531 1.14e-100 321.0 COG1530@1|root,COG3266@1|root,COG1530@2|Bacteria,COG3266@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales 135613|Chromatiales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_874159_1 1249480.B649_10180 8.38e-146 419.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2YMJU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1005832_1 32024.JMTI01000009_gene993 0.000263 43.1 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,42MI1@68525|delta/epsilon subdivisions,2YMPQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Sulfatase eptA - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_1005832_2 1137799.GZ78_16435 8.05e-43 153.0 COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria,1XQ2D@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF4143) - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_711407_1 519989.ECTPHS_07242 5.67e-94 290.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales 135613|Chromatiales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_548828_1 1304284.L21TH_2718 5.67e-21 95.9 COG2172@1|root,COG2203@1|root,COG2208@1|root,COG3920@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3920@2|Bacteria,1VA58@1239|Firmicutes,24E91@186801|Clostridia,36M6P@31979|Clostridiaceae 186801|Clostridia T GAF domain - - - - - - - - - - - - GAF,HATPase_c k59_874160_1 767817.Desgi_1697 3.05e-49 180.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,2602M@186807|Peptococcaceae 186801|Clostridia J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind k59_449376_1 395493.BegalDRAFT_2459 4.66e-67 225.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales 72273|Thiotrichales P heavy metal translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_580901_1 247634.GPB2148_2959 2.25e-14 75.5 COG3009@1|root,COG3009@2|Bacteria,1PDJX@1224|Proteobacteria,1TAM8@1236|Gammaproteobacteria,1JBA0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S ABC-type transport auxiliary lipoprotein component - - - ko:K09857 - - - - ko00000 - - - ABC_trans_aux k59_449379_1 1168034.FH5T_15310 3.51e-90 281.0 COG2866@1|root,COG2866@2|Bacteria,4NH4I@976|Bacteroidetes 976|Bacteroidetes E Peptidase M14 - - - - - - - - - - - - Peptidase_M14 k59_907258_1 631362.Thi970DRAFT_02745 1.59e-87 283.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_805837_2 1122962.AULH01000020_gene3605 3.82e-18 87.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,36YGW@31993|Methylocystaceae 28211|Alphaproteobacteria E FAD dependent oxidoreductase ordL - - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO k59_679816_1 555778.Hneap_1728 2.12e-38 145.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW89@135613|Chromatiales 135613|Chromatiales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_940511_1 929558.SMGD1_0835 4.37e-60 199.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2YMQ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_123262_1 234267.Acid_7696 1.45e-80 259.0 COG1166@1|root,COG1166@2|Bacteria,3Y449@57723|Acidobacteria 57723|Acidobacteria E Pyridoxal-dependent decarboxylase, pyridoxal binding domain - - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_548844_1 1453505.JASY01000001_gene3615 1.6e-102 320.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia,2NVHB@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_776595_1 1144310.PMI07_004955 6.35e-30 110.0 COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,2UCNX@28211|Alphaproteobacteria,4BGCZ@82115|Rhizobiaceae 28211|Alphaproteobacteria L GIY-YIG catalytic domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_352961_1 1121405.dsmv_0564 2.26e-107 345.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_90514_1 1168034.FH5T_09335 1.17e-27 111.0 COG4704@1|root,COG4704@2|Bacteria,4NGPF@976|Bacteroidetes,2FNAC@200643|Bacteroidia 976|Bacteroidetes S Bacterial Ig-like domain - - - - - - - - - - - - Big_5,fn3_3 k59_90514_2 1168034.FH5T_09330 2.56e-21 93.2 COG0557@1|root,COG0557@2|Bacteria,4NE7T@976|Bacteroidetes,2FMM6@200643|Bacteroidia 976|Bacteroidetes J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573,ko:K12585 ko03018,map03018 M00391 - - ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_679821_2 1121456.ATVA01000012_gene2750 1.24e-50 172.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2M9I8@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_284526_1 387093.SUN_2285 5.09e-106 318.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2YN43@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_841772_1 765914.ThisiDRAFT_1640 8.95e-90 273.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_711425_1 1168034.FH5T_09335 5.07e-71 233.0 COG4704@1|root,COG4704@2|Bacteria,4NGPF@976|Bacteroidetes,2FNAC@200643|Bacteroidia 976|Bacteroidetes S Bacterial Ig-like domain - - - - - - - - - - - - Big_5,fn3_3 k59_1037617_1 869213.JCM21142_167 2.28e-221 635.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia 976|Bacteroidetes G PFAM Glycosyl Hydrolase - - - - - - - - - - - - Glyco_hydro_92 k59_517113_1 1121405.dsmv_0691 4.12e-189 541.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_90516_1 1537917.JU82_07000 1.47e-225 639.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,42N04@68525|delta/epsilon subdivisions,2YMF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_90516_2 1537917.JU82_07005 3.43e-91 276.0 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,42MS3@68525|delta/epsilon subdivisions,2YM90@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar motor switch protein fliG GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_585555_1 1293054.HSACCH_01519 0.000203 45.4 COG2834@1|root,COG2834@2|Bacteria,1V6F3@1239|Firmicutes,24MGP@186801|Clostridia,3WAQP@53433|Halanaerobiales 186801|Clostridia M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_193909_1 570967.JMLV01000004_gene690 2.01e-08 59.3 COG1712@1|root,COG1712@2|Bacteria,1MX8S@1224|Proteobacteria,2TV48@28211|Alphaproteobacteria,2JREV@204441|Rhodospirillales 204441|Rhodospirillales H Domain of unknown function DUF108 - - - - - - - - - - - - DUF108,NAD_binding_3 k59_485566_1 391615.ABSJ01000039_gene1801 7.2e-81 248.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1J4MF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_127363_1 1249480.B649_05040 1.03e-95 282.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2YN1G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_127363_2 563040.Saut_0956 3.69e-37 132.0 COG2230@1|root,COG2230@2|Bacteria,1QZ24@1224|Proteobacteria,43CEA@68525|delta/epsilon subdivisions,2YTBV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Methionine biosynthesis protein MetW - - - - - - - - - - - - CMAS k59_454705_1 500153.JOEK01000006_gene5523 3.95e-22 101.0 COG0477@1|root,COG2814@2|Bacteria,2GJK6@201174|Actinobacteria 201174|Actinobacteria EGP Drug resistance transporter, bcr cfla subfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_390072_2 42565.FP66_11210 6.3e-60 192.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1XK3H@135619|Oceanospirillales 135619|Oceanospirillales D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_357091_1 1384056.N787_00870 5.13e-05 45.1 COG0266@1|root,COG0266@2|Bacteria,1N1J5@1224|Proteobacteria,1RNS9@1236|Gammaproteobacteria,1X31D@135614|Xanthomonadales 135614|Xanthomonadales L Formamidopyrimidine-DNA glycosylase N-terminal domain - - - - - - - - - - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_357091_2 493475.GARC_2267 9.41e-46 149.0 COG4323@1|root,COG4323@2|Bacteria,1N16T@1224|Proteobacteria,1S8V6@1236|Gammaproteobacteria,4683B@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane - - - - - - - - - - - - DUF962 k59_1009869_1 875454.BAEW01000001_gene285 4.12e-06 48.9 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,22FXF@1570339|Peptoniphilaceae 186801|Clostridia V ABC transporter, ATP-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1009869_2 685778.AORL01000022_gene1493 4.89e-11 66.2 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,2K18J@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_390074_1 1121405.dsmv_0691 1.79e-84 265.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_781130_1 1165841.SULAR_09779 1.86e-71 214.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2YPES@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the thioredoxin family trx2 - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_193920_1 886379.AEWI01000023_gene8 1.4e-59 204.0 COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,2FMBR@200643|Bacteroidia,3XJ41@558415|Marinilabiliaceae 976|Bacteroidetes L RQC recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_24230_1 666681.M301_1046 2.22e-12 65.5 COG3450@1|root,COG3450@2|Bacteria 2|Bacteria I Protein of unknown function (DUF861) - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_24230_2 1121926.AXWO01000013_gene2116 1.4e-65 221.0 COG1926@1|root,COG2312@1|root,COG1926@2|Bacteria,COG2312@2|Bacteria,2GJUU@201174|Actinobacteria 201174|Actinobacteria Q phosphoribosyltransferase - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K07100 - - - - ko00000 - - - Erythro_esteras,Pribosyltran k59_24230_3 640512.BC1003_4746 1.83e-09 58.9 COG2187@1|root,COG2187@2|Bacteria,1R98V@1224|Proteobacteria,2VM22@28216|Betaproteobacteria,1K6U0@119060|Burkholderiaceae 28216|Betaproteobacteria S AAA domain - - - - - - - - - - - - - k59_1009876_1 1172190.M947_02700 8.36e-42 157.0 2C99Z@1|root,2Z9YV@2|Bacteria,1N0B7@1224|Proteobacteria,42P3M@68525|delta/epsilon subdivisions,2YMWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3373) - - - - - - - - - - - - DUF3373 k59_289100_1 565034.BHWA1_02118 7.02e-07 50.1 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,2J5A7@203691|Spirochaetes 203691|Spirochaetes E Belongs to the hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth,PRA-CH,PRA-PH k59_289100_2 1282887.AUJG01000002_gene865 6.42e-46 160.0 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia 186801|Clostridia E Histidinol phosphate phosphatase, HisJ family hisK - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP k59_24235_1 96561.Dole_0075 2.12e-74 242.0 COG4770@1|root,COG5016@1|root,COG4770@2|Bacteria,COG5016@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria,2MHKV@213118|Desulfobacterales 28221|Deltaproteobacteria CI Conserved carboxylase domain - - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_618504_1 762982.HMPREF9442_02509 2.82e-45 171.0 COG2335@1|root,COG2335@2|Bacteria,4NGU3@976|Bacteroidetes,2FRBQ@200643|Bacteroidia 976|Bacteroidetes M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - ko:K19519 - - - - ko00000,ko04516 - - - Fasciclin k59_257806_1 1168034.FH5T_20040 1.96e-87 268.0 COG0477@1|root,COG2814@2|Bacteria,4NI1T@976|Bacteroidetes,2FRJG@200643|Bacteroidia 976|Bacteroidetes EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_257806_2 1168034.FH5T_20035 2.2e-64 206.0 COG2502@1|root,COG2502@2|Bacteria,4NFZA@976|Bacteroidetes,2FMP0@200643|Bacteroidia 976|Bacteroidetes E aspartate--ammonia ligase asnA - 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 - R00483 RC00010 ko00000,ko00001,ko01000 - - - AsnA k59_944970_1 1123326.JFBL01000004_gene2118 2.94e-53 188.0 COG1287@1|root,COG1287@2|Bacteria,1R481@1224|Proteobacteria,42MNZ@68525|delta/epsilon subdivisions,2YMU3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Oligosaccharyl transferase, STT3 subunit pglB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0034645,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046872,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.99.18,2.4.99.19 ko:K07151,ko:K17251 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_553478_1 572480.Arnit_2275 3.47e-15 75.9 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,42N9C@68525|delta/epsilon subdivisions,2YNTX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P cation diffusion facilitator family transporter - - - - - - - - - - - - Cation_efflux k59_553478_2 944547.ABLL_1191 4.45e-67 218.0 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2YN1T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF21 - - - - - - - - - - - - CBS,DUF21 k59_390078_4 883156.HMPREF9282_00045 4.28e-35 143.0 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4H1XX@909932|Negativicutes 909932|Negativicutes M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_485593_1 326423.RBAM_022010 9.36e-29 119.0 COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HV19@91061|Bacilli,1ZD1S@1386|Bacillus 91061|Bacilli Q Polyketide synthase of type I - - - ko:K13612,ko:K13613 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,NAD_binding_4,PP-binding,PS-DH,ketoacyl-synt k59_911398_1 436114.SYO3AOP1_0123 7.32e-52 184.0 COG0165@1|root,COG0165@2|Bacteria,2G3PT@200783|Aquificae 200783|Aquificae E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_746650_1 765911.Thivi_1421 5.6e-78 242.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales 135613|Chromatiales CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1009885_2 563040.Saut_2016 1.33e-28 104.0 2C0BV@1|root,300E8@2|Bacteria,1Q68S@1224|Proteobacteria,432Q2@68525|delta/epsilon subdivisions,2YSMD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_289109_1 1249480.B649_09310 6.12e-77 246.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,42MIH@68525|delta/epsilon subdivisions 1224|Proteobacteria T PFAM EAL domain protein - - - - - - - - - - - - EAL,HDOD k59_289109_2 1172190.M947_06345 1.39e-39 146.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,42PUG@68525|delta/epsilon subdivisions,2YN09@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB-dependent copper receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_650561_2 33035.JPJF01000050_gene850 2.43e-21 95.9 COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,3XZAP@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_1042291_1 247490.KSU1_C0730 1.67e-23 105.0 COG2234@1|root,COG3291@1|root,COG3420@1|root,COG4409@1|root,COG5184@1|root,COG5276@1|root,COG2234@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4409@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity iap GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 ko:K01179,ko:K03929,ko:K09612,ko:K12287,ko:K19701,ko:K19702 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko01002,ko02044 - CE10,GH5,GH9 - Beta_helix,Peptidase_M28 k59_94395_1 768671.ThimaDRAFT_0916 4.06e-106 327.0 COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,1RQSW@1236|Gammaproteobacteria,1WZYX@135613|Chromatiales 135613|Chromatiales C Cytochrome c oxidase subunit nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - COX2,Cupredoxin_1 k59_289111_1 768671.ThimaDRAFT_0602 4.31e-91 297.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_683844_1 588581.Cpap_0009 2.3e-96 316.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,3WSTF@541000|Ruminococcaceae 186801|Clostridia Q Beta-ketoacyl synthase - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_485609_1 56780.SYN_00640 1.69e-74 238.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MQ50@213462|Syntrophobacterales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_357127_1 1260251.SPISAL_02775 1.29e-21 90.5 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1WXAH@135613|Chromatiales 135613|Chromatiales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_357127_2 472759.Nhal_3529 9.45e-56 176.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1WYA2@135613|Chromatiales 135613|Chromatiales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_454771_1 944547.ABLL_0630 3.25e-71 225.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2YMK1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria OU signal peptide peptidase SppA, 36K type sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_257829_1 653733.Selin_0035 6.6e-90 292.0 COG3696@1|root,COG3696@2|Bacteria 2|Bacteria P silver ion transport cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_781174_1 563040.Saut_0347 3.08e-45 150.0 2AK35@1|root,31ASX@2|Bacteria,1Q62J@1224|Proteobacteria,42W2T@68525|delta/epsilon subdivisions,2YQDE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_781174_2 563040.Saut_0348 1.48e-21 86.7 2EHK0@1|root,33BBV@2|Bacteria,1NGIK@1224|Proteobacteria,42WYY@68525|delta/epsilon subdivisions,2YQPD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Prokaryotic metallothionein - - - ko:K06950 - - - - ko00000 - - - Metallothio_Pro k59_128170_2 387093.SUN_2247 6.42e-131 387.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2YMC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Long-chain fatty acid transport protein - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_162584_1 90814.KL370891_gene1925 7.79e-18 85.9 COG0526@1|root,COG0526@2|Bacteria,1RB6H@1224|Proteobacteria,1S2QN@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,LGT k59_61089_1 1168034.FH5T_17710 2.49e-41 154.0 COG0683@1|root,COG1388@1|root,COG0683@2|Bacteria,COG1388@2|Bacteria,4NG96@976|Bacteroidetes,2FNR1@200643|Bacteroidia 976|Bacteroidetes M LysM domain protein lysM - - - - - - - - - - - ANF_receptor,LysM,Peripla_BP_6 k59_846629_1 1278307.KB907006_gene229 4.41e-63 207.0 COG0859@1|root,COG0859@2|Bacteria,1R4U8@1224|Proteobacteria,1RQY4@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 k59_586357_2 1049564.TevJSym_bb00340 2.05e-21 95.5 COG2199@1|root,COG3706@2|Bacteria,1NE0J@1224|Proteobacteria,1SF4P@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF k59_421148_1 472759.Nhal_0347 4.48e-27 108.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1WXHN@135613|Chromatiales 135613|Chromatiales Q PFAM toluene tolerance - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_128189_1 911045.PSE_3737 1.8e-26 114.0 COG1289@1|root,COG1289@2|Bacteria 2|Bacteria S transmembrane transporter activity VPA1578 - - - - - - - - - - - FUSC k59_912143_1 225849.swp_3249 2.59e-27 109.0 COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,1RS0G@1236|Gammaproteobacteria,2QA1V@267890|Shewanellaceae 1236|Gammaproteobacteria KT PFAM PspA IM30 family protein pspA GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141 - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_258550_1 572544.Ilyop_1713 1.97e-147 430.0 COG0793@1|root,COG0793@2|Bacteria,3786X@32066|Fusobacteria 32066|Fusobacteria M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_258550_2 572544.Ilyop_1714 3.93e-141 404.0 COG1189@1|root,COG1189@2|Bacteria,378UE@32066|Fusobacteria 32066|Fusobacteria J Ribosomal RNA large subunit methyltransferase J rrmJ - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_258550_3 572544.Ilyop_1715 2.66e-89 272.0 COG2771@1|root,COG2771@2|Bacteria,37CVK@32066|Fusobacteria 32066|Fusobacteria K HD domain - - - - - - - - - - - - GerE,HD k59_977768_1 572544.Ilyop_1395 4.85e-72 225.0 COG0725@1|root,COG0725@2|Bacteria,37A0K@32066|Fusobacteria 32066|Fusobacteria P ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_421167_1 1123276.KB893301_gene4324 8.76e-41 159.0 COG1044@1|root,COG5295@1|root,COG1044@2|Bacteria,COG5295@2|Bacteria,4NMJW@976|Bacteroidetes,47XBE@768503|Cytophagia 976|Bacteroidetes UW Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - - - - - - - - - - - DUF1566,Peptidase_S74 k59_258569_1 1185652.USDA257_c27240 1.03e-19 95.5 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1NS2Y@1224|Proteobacteria,2UNZQ@28211|Alphaproteobacteria,4BI13@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc k59_554428_1 563040.Saut_0346 6.03e-31 125.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43CE4@68525|delta/epsilon subdivisions,2YTBQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM EAL domain - - - - - - - - - - - - DUF3365,EAL,GGDEF k59_846656_1 1121403.AUCV01000002_gene570 1.89e-121 357.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJEI@28221|Deltaproteobacteria,2MIFI@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2910 ThiC_Rad_SAM k59_747421_1 1142394.PSMK_12070 4.33e-08 62.0 COG2304@1|root,COG2304@2|Bacteria,2J434@203682|Planctomycetes 203682|Planctomycetes S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_586390_1 1291050.JAGE01000002_gene3676 5e-29 120.0 COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes 1239|Firmicutes Q synthase - - - - - - - - - - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_1043008_1 765912.Thimo_2795 4.45e-10 60.8 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M20A family. ArgE subfamily - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1043008_2 572477.Alvin_2831 1.31e-37 137.0 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales 135613|Chromatiales K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,DUF3335 k59_226962_1 1168034.FH5T_11850 2.88e-199 567.0 COG0034@1|root,COG0034@2|Bacteria,4NFSM@976|Bacteroidetes,2FM3Y@200643|Bacteroidia 976|Bacteroidetes F Class II glutamine amidotransferase purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7 k59_128236_1 446466.Cfla_2215 1.98e-33 126.0 COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,4F24S@85016|Cellulomonadaceae 201174|Actinobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - iNJ661.Rv2388c HemN_C,Radical_SAM k59_945871_1 1047013.AQSP01000103_gene1154 2.96e-61 196.0 COG5340@1|root,COG5340@2|Bacteria 2|Bacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - AbiEi_4 k59_686862_1 1346791.M529_17360 2.52e-78 246.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2TR5F@28211|Alphaproteobacteria,2K04J@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 - R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_588827_1 1049564.TevJSym_ab01990 5.14e-53 171.0 COG0636@1|root,COG0636@2|Bacteria,1REA9@1224|Proteobacteria,1S51I@1236|Gammaproteobacteria 1236|Gammaproteobacteria C ATP synthase subunit C - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C k59_588827_2 105559.Nwat_1003 1.84e-09 57.0 COG1436@1|root,COG1436@2|Bacteria,1MZUE@1224|Proteobacteria,1SATX@1236|Gammaproteobacteria,1WYZV@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane - - - - - - - - - - - - ATP-synt_F k59_752814_1 869213.JCM21142_114624 8.35e-84 250.0 COG0386@1|root,COG0386@2|Bacteria,4NM6G@976|Bacteroidetes,47PPR@768503|Cytophagia 976|Bacteroidetes O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_393289_1 1121898.Q766_18615 1.28e-14 77.0 COG0526@1|root,COG0526@2|Bacteria,4NNXC@976|Bacteroidetes,1I2AF@117743|Flavobacteriia,2NV4Q@237|Flavobacterium 976|Bacteroidetes CO Outer membrane protein Omp28 - - - - - - - - - - - - Omp28,Thioredoxin k59_948923_1 1537917.JU82_01615 5.66e-151 444.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2YMJ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell division protein FtsI penicillin-binding protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_131674_1 247639.MGP2080_04185 7.14e-37 139.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_736_1 305900.GV64_00440 4.87e-31 124.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,1XH4M@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_229856_1 493475.GARC_1326 1.79e-76 239.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,465EE@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_948927_1 1417296.U879_08040 5.66e-118 348.0 COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,2U4HP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Radical SAM - - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_948927_2 1288298.rosmuc_01225 2.43e-07 52.0 COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria 28211|Alphaproteobacteria H biotin lipoate A B protein ligase - - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_33671_1 748658.KB907312_gene1472 5.72e-71 229.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_99030_1 1121405.dsmv_1784 4.26e-309 867.0 COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,42TK8@68525|delta/epsilon subdivisions,2WQUX@28221|Deltaproteobacteria,2MPB3@213118|Desulfobacterales 28221|Deltaproteobacteria L DEAD DEAH box helicase domain protein - - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,Helicase_C k59_99030_2 246195.DNO_0174 5.53e-205 566.0 2C2MI@1|root,2ZBMN@2|Bacteria,1RAX0@1224|Proteobacteria,1S35B@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF1837) - - - - - - - - - - - - DUF1837 k59_99030_3 335284.Pcryo_0940 6.84e-170 485.0 COG4268@1|root,COG4268@2|Bacteria,1R1FP@1224|Proteobacteria,1RZIR@1236|Gammaproteobacteria 1236|Gammaproteobacteria V DNA restriction-modification system mcrC - - ko:K19147 - - - - ko00000,ko02048 - - - McrBC k59_99030_4 1198232.CYCME_0984 0.0 996.0 COG1401@1|root,COG2256@1|root,COG1401@2|Bacteria,COG2256@2|Bacteria,1MYQM@1224|Proteobacteria,1RSU7@1236|Gammaproteobacteria,46138@72273|Thiotrichales 72273|Thiotrichales V AAA domain (dynein-related subfamily) - - - ko:K07452 - - - - ko00000,ko01000,ko02048 - - - AAA_5 k59_99030_5 556268.OFAG_01888 1.96e-78 236.0 COG1112@1|root,COG1112@2|Bacteria 2|Bacteria L Superfamily I DNA and RNA helicases and helicase subunits - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,PDDEXK_1 k59_556729_1 1168059.KB899087_gene4287 2.45e-14 72.8 COG1335@1|root,COG1335@2|Bacteria,1RDHA@1224|Proteobacteria,2U71S@28211|Alphaproteobacteria,3F1GB@335928|Xanthobacteraceae 28211|Alphaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_556729_2 388413.ALPR1_14989 2.47e-38 130.0 2E3QV@1|root,32YNP@2|Bacteria,4NX04@976|Bacteroidetes 976|Bacteroidetes S Domain of unknown function (DUF1905) - - - - - - - - - - - - DUF1905 k59_556729_3 411477.PARMER_02315 7.33e-61 206.0 COG0021@1|root,COG0021@2|Bacteria,4P14U@976|Bacteroidetes,2FN0P@200643|Bacteroidia,22WF7@171551|Porphyromonadaceae 976|Bacteroidetes G Belongs to the transketolase family tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_524052_1 387093.SUN_1506 5.97e-78 249.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2YMJV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_589436_1 1121405.dsmv_0961 3.64e-12 65.5 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MKCK@213118|Desulfobacterales 28221|Deltaproteobacteria U Preprotein translocase subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_589436_2 1121405.dsmv_1104 8.77e-60 196.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2MIZI@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_1014316_1 1165841.SULAR_05843 1.35e-76 242.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2YN91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_458662_1 1168034.FH5T_05030 1.33e-193 543.0 COG0195@1|root,COG0195@2|Bacteria,4NFGA@976|Bacteroidetes,2FNJF@200643|Bacteroidia 976|Bacteroidetes K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k59_458662_2 1168034.FH5T_05025 1.66e-30 120.0 COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,2FM01@200643|Bacteroidia 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_556738_1 2340.JV46_22770 2.44e-70 228.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1530 Ribonucleases G and E rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_327978_1 563040.Saut_1264 3.89e-159 462.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42NK1@68525|delta/epsilon subdivisions,2YMHN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the AAA ATPase family ftsH1 - - - - - - - - - - - AAA,Peptidase_M41 k59_741_2 387093.SUN_0717 3.93e-167 470.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2YM9Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Enoyl- acyl-carrier-protein reductase NADH fabI GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_741_3 1165841.SULAR_04382 5.94e-39 135.0 COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2YQ20@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EJ GlutRNAGln amidotransferase subunit D - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_785449_2 1168034.FH5T_12000 3.14e-57 179.0 COG1539@1|root,COG1539@2|Bacteria,4NQ53@976|Bacteroidetes,2FU2A@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_785449_3 1123278.KB893430_gene93 2.03e-22 95.9 COG0008@1|root,COG0008@2|Bacteria,4NFCC@976|Bacteroidetes,47MT0@768503|Cytophagia 976|Bacteroidetes J PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_883611_1 930169.B5T_04140 3.32e-42 148.0 COG1120@1|root,COG1120@2|Bacteria,1MWPV@1224|Proteobacteria,1T1UT@1236|Gammaproteobacteria 1236|Gammaproteobacteria HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components fecE - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_883611_2 305900.GV64_09685 2.93e-43 151.0 28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria,1RP8T@1236|Gammaproteobacteria,1XIH6@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_229876_1 316407.85677007 2.77e-24 102.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,3XNPE@561|Escherichia 1236|Gammaproteobacteria E involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_654867_2 944547.ABLL_2147 1.05e-89 271.0 COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,42KZB@68525|delta/epsilon subdivisions,2YN63@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_850926_1 1236514.BAKL01000005_gene627 1.33e-110 322.0 COG5520@1|root,COG5520@2|Bacteria,4NF4C@976|Bacteroidetes,2FNPT@200643|Bacteroidia,4AM5V@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 30 family - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - Glyco_hydro_30,Glyco_hydro_30C k59_458669_1 1121405.dsmv_3378 2.33e-59 192.0 COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,42U9T@68525|delta/epsilon subdivisions,2WQPQ@28221|Deltaproteobacteria,2MK7H@213118|Desulfobacterales 28221|Deltaproteobacteria S protein conserved in bacteria (DUF2064) - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_687503_1 1282356.H045_01425 4.89e-78 244.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1YP65@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_33698_1 1168034.FH5T_20675 1.47e-124 360.0 COG0526@1|root,COG0526@2|Bacteria,4NHEC@976|Bacteroidetes 976|Bacteroidetes CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,DUF4369,DUF5106,Thioredoxin_8 k59_33698_2 395493.BegalDRAFT_1653 6.69e-09 55.8 COG4337@1|root,COG4337@2|Bacteria,1RD42@1224|Proteobacteria,1S6G0@1236|Gammaproteobacteria,461A8@72273|Thiotrichales 72273|Thiotrichales S protein conserved in bacteria - - - - - - - - - - - - - k59_556751_1 1168034.FH5T_13690 6.3e-187 523.0 COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,2FMGP@200643|Bacteroidia 976|Bacteroidetes S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_556751_2 1168034.FH5T_13685 5.27e-75 231.0 COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,2FNSY@200643|Bacteroidia 976|Bacteroidetes S protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_131718_1 1168034.FH5T_09140 9.08e-22 92.4 COG3595@1|root,COG3595@2|Bacteria,4NIA2@976|Bacteroidetes 976|Bacteroidetes S Putative auto-transporter adhesin, head GIN domain - - - - - - - - - - - - DUF2807 k59_785471_1 756272.Plabr_0065 7.59e-64 205.0 COG5361@1|root,COG5361@2|Bacteria,2IY8Y@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214,DUF1254 k59_818186_1 196162.Noca_3306 2.58e-38 142.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DPFV@85009|Propionibacteriales 201174|Actinobacteria EH TPP binding domain protein - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_818186_2 644282.Deba_2973 3.79e-32 119.0 COG1309@1|root,COG1309@2|Bacteria,1MYVR@1224|Proteobacteria,42SV2@68525|delta/epsilon subdivisions,2WPSA@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_33706_1 1168034.FH5T_06525 2.96e-84 273.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,2FM8X@200643|Bacteroidia 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_458694_1 563040.Saut_1115 3.33e-113 337.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2YTA6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1014352_1 1123073.KB899241_gene3340 3.07e-97 297.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1X3S9@135614|Xanthomonadales 135614|Xanthomonadales GM Belongs to the mannose-6-phosphate isomerase type 2 family cpsB GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_948981_1 391598.FBBAL38_09659 2.21e-89 273.0 COG3677@1|root,COG3677@2|Bacteria,4NHYS@976|Bacteroidetes,1I68J@117743|Flavobacteriia 976|Bacteroidetes L COG2207 AraC-type DNA-binding domain-containing proteins - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_981598_1 376686.Fjoh_3190 1.1e-44 164.0 COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,4NG9Q@976|Bacteroidetes,1I11X@117743|Flavobacteriia,2NYP0@237|Flavobacterium 976|Bacteroidetes S Uncharacterised conserved protein (DUF2156) - - 2.3.2.3 ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504 2.A.1.3.37 - - DUF2156,LPG_synthase_TM k59_654906_1 1165841.SULAR_09189 2.77e-94 286.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2YN15@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Glycosyl hydrolase family 3 - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Amidase_2,Glyco_hydro_3 k59_589486_2 582515.KR51_00014470 1.99e-45 154.0 COG0666@1|root,COG0666@2|Bacteria,1GEB9@1117|Cyanobacteria 1117|Cyanobacteria S Ankyrin repeat - - - - - - - - - - - - Ank_2 k59_425932_1 880073.Calab_1086 1.69e-28 113.0 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2NQE8@2323|unclassified Bacteria 2|Bacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - GAF,GAF_2,HD,HD_5 k59_131745_1 1121403.AUCV01000001_gene993 9.51e-147 429.0 COG1840@1|root,COG1840@2|Bacteria,1N5J9@1224|Proteobacteria,42PSR@68525|delta/epsilon subdivisions,2WJI3@28221|Deltaproteobacteria,2MHTI@213118|Desulfobacterales 28221|Deltaproteobacteria P Bacterial extracellular solute-binding protein - - - - - - - - - - - - DUF1858,SBP_bac_6 k59_328040_1 749222.Nitsa_1575 2.06e-66 224.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2YMJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_360703_1 1121405.dsmv_0618 2.54e-159 463.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria,2MHWQ@213118|Desulfobacterales 28221|Deltaproteobacteria C reductase, alpha subunit aprA - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_720224_1 572544.Ilyop_1483 3.67e-59 190.0 COG3958@1|root,COG3958@2|Bacteria,378ZW@32066|Fusobacteria 32066|Fusobacteria G Psort location Cytoplasmic, score - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_720224_2 572544.Ilyop_1484 1.56e-85 258.0 COG3959@1|root,COG3959@2|Bacteria,378CZ@32066|Fusobacteria 32066|Fusobacteria G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_752892_1 933262.AXAM01000039_gene1156 3.42e-69 223.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2MHWD@213118|Desulfobacterales 28221|Deltaproteobacteria NU type II secretion system pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_328042_1 313628.LNTAR_03719 1.29e-09 64.7 COG0155@1|root,COG0155@2|Bacteria 2|Bacteria C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family cysI - 1.7.1.15,1.7.7.1,1.8.1.2,1.8.7.1 ko:K00362,ko:K00366,ko:K00381,ko:K00392 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00530,M00531 R00787,R00790,R00858,R00859,R03600 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 - - - HEPN,NIR_SIR,NIR_SIR_ferr k59_654913_1 1033810.HLPCO_001456 2.01e-42 150.0 COG1473@1|root,COG1473@2|Bacteria,2NPHI@2323|unclassified Bacteria 2|Bacteria S Peptidase dimerisation domain dapL - 3.5.1.47 ko:K05823,ko:K21613 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00525 R02733 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_654913_2 634498.mru_0153 7.27e-64 209.0 COG0253@1|root,arCOG02255@2157|Archaea,2XUYX@28890|Euryarchaeota,23NTQ@183925|Methanobacteria 183925|Methanobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_654913_3 1499684.CCNP01000020_gene2496 7.88e-107 317.0 COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,36DMX@31979|Clostridiaceae 186801|Clostridia E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_883656_1 1114922.CIFAM_21_01050 3.96e-24 101.0 COG0791@1|root,COG0791@2|Bacteria,1R105@1224|Proteobacteria,1T53U@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 k59_981614_1 1249627.D779_0855 1.07e-102 331.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_262344_1 1192759.AKIB01000020_gene3045 7.74e-84 306.0 COG1525@1|root,COG3170@1|root,COG1525@2|Bacteria,COG3170@2|Bacteria,1Q45C@1224|Proteobacteria,2U08F@28211|Alphaproteobacteria,2K8Y1@204457|Sphingomonadales 204457|Sphingomonadales NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_1020112_1 1122185.N792_04250 6.91e-08 53.5 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1X340@135614|Xanthomonadales 135614|Xanthomonadales L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_1020112_2 319003.Bra1253DRAFT_04957 6.33e-17 77.8 COG5488@1|root,COG5488@2|Bacteria,1NPQQ@1224|Proteobacteria,2UB81@28211|Alphaproteobacteria,3JRPQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_235664_1 398767.Glov_3396 5.23e-47 152.0 COG2963@1|root,COG2963@2|Bacteria,1N06K@1224|Proteobacteria 1224|Proteobacteria L COG2963, Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_28,HTH_Tnp_1 k59_300424_1 1168034.FH5T_10560 4.66e-38 129.0 COG0792@1|root,COG0792@2|Bacteria,4NS7E@976|Bacteroidetes,2FSN9@200643|Bacteroidia 976|Bacteroidetes L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_300424_2 1168034.FH5T_10565 5.05e-59 184.0 COG2315@1|root,COG2315@2|Bacteria,4NS6J@976|Bacteroidetes,2FTTX@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - YjbR k59_300424_3 1168034.FH5T_10570 1.57e-155 448.0 COG3579@1|root,COG3579@2|Bacteria,4NE02@976|Bacteroidetes,2FPW0@200643|Bacteroidia 976|Bacteroidetes E Papain family cysteine protease - - 3.4.22.40 ko:K01372 - - - - ko00000,ko01000,ko01002 - - - Peptidase_C1,Peptidase_C1_2 k59_300424_4 1168034.FH5T_10575 1.26e-32 114.0 COG2501@1|root,COG2501@2|Bacteria,4NYDC@976|Bacteroidetes,2FZ77@200643|Bacteroidia 976|Bacteroidetes S S4 domain - - - ko:K14761 - - - - ko00000,ko03009 - - - S4_2 k59_300424_5 1168034.FH5T_13110 6.13e-37 129.0 2BXIZ@1|root,32R1E@2|Bacteria,4NVX8@976|Bacteroidetes,2G3AW@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_594983_1 1168034.FH5T_11715 4.06e-157 451.0 COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,2FP4D@200643|Bacteroidia 976|Bacteroidetes L helicase superfamily c-terminal domain rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_334345_1 402777.KB235904_gene3415 7.43e-15 77.0 COG0438@1|root,COG0438@2|Bacteria,1G4GF@1117|Cyanobacteria,1HF1B@1150|Oscillatoriales 1117|Cyanobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_334345_2 1123255.JHYS01000012_gene1293 9.82e-38 146.0 COG2931@1|root,COG2931@2|Bacteria,1RK60@1224|Proteobacteria,2VUNF@28216|Betaproteobacteria 28216|Betaproteobacteria Q Hep Hag repeat protein - - - - - - - - - - - - DUF4214 k59_398991_1 377629.TERTU_3754 7.13e-25 105.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RR99@1236|Gammaproteobacteria,2PPM6@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_72390_1 326298.Suden_2031 1.88e-84 276.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2YMTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_235669_1 1537917.JU82_04985 5.18e-147 427.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,42MNG@68525|delta/epsilon subdivisions,2YNM4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation - - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_790604_1 338966.Ppro_0411 5.37e-45 167.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales 28221|Deltaproteobacteria V TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_856812_2 292.DM42_949 5.51e-06 54.3 COG4627@1|root,COG4627@2|Bacteria,1PDQR@1224|Proteobacteria,2W33A@28216|Betaproteobacteria 28216|Betaproteobacteria S Pfam Methyltransferase - - - - - - - - - - - - - k59_366688_1 388413.ALPR1_02210 3.99e-18 91.3 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47U6P@768503|Cytophagia 976|Bacteroidetes T SnoaL-like domain - - - - - - - - - - - - HATPase_c,HisKA,SnoaL_3 k59_72391_1 387093.SUN_1098 2.3e-64 201.0 2BEW6@1|root,328MU@2|Bacteria,1QAUA@1224|Proteobacteria,42VY6@68525|delta/epsilon subdivisions,2YQED@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_72391_2 563040.Saut_1529 7.05e-20 80.9 COG4895@1|root,COG4895@2|Bacteria,1N7TD@1224|Proteobacteria,42V1D@68525|delta/epsilon subdivisions,2YQK9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterized conserved protein (DUF2196) - - - - - - - - - - - - DUF2196 k59_628026_1 997346.HMPREF9374_0709 2.58e-77 244.0 COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,4HBAV@91061|Bacilli,27B62@186824|Thermoactinomycetaceae 91061|Bacilli I 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_464996_1 5062.CADAORAP00002323 1.28e-21 97.1 COG0030@1|root,KOG0820@2759|Eukaryota,38EA2@33154|Opisthokonta,3NU08@4751|Fungi,3QNDR@4890|Ascomycota,20EK6@147545|Eurotiomycetes,3S3NH@5042|Eurotiales 4751|Fungi H Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family DIM1 GO:0000154,GO:0000179,GO:0000456,GO:0000462,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030490,GO:0030684,GO:0030686,GO:0031167,GO:0031974,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0052909,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360,GO:1990904 2.1.1.183 ko:K14191 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_464996_2 283942.IL0507 5.41e-97 293.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,2QF8Q@267893|Idiomarinaceae 1236|Gammaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046385,GO:0046483,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_464996_4 665956.HMPREF1032_01321 1.19e-58 210.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WGKX@541000|Ruminococcaceae 186801|Clostridia L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_105479_1 1005048.CFU_1923 6.11e-19 86.3 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,473D3@75682|Oxalobacteraceae 28216|Betaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_105479_2 1286106.MPL1_04155 4.42e-15 69.3 COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,1SH40@1236|Gammaproteobacteria,461GH@72273|Thiotrichales 72273|Thiotrichales S Uncharacterized protein conserved in bacteria (DUF2065) - - - ko:K09937 - - - - ko00000 - - - DUF2065 k59_105479_3 1249627.D779_0214 1.71e-20 89.7 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales 135613|Chromatiales E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_4407_2 457398.HMPREF0326_01446 1.65e-36 131.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2M8HR@213115|Desulfovibrionales 28221|Deltaproteobacteria EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_954363_1 387093.SUN_2345 6.62e-50 160.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2YP73@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_954363_2 1165841.SULAR_07910 1.81e-67 206.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,42RE3@68525|delta/epsilon subdivisions,2YP8H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_431082_1 1120951.AUBG01000020_gene1801 1.01e-55 177.0 COG0662@1|root,COG0662@2|Bacteria,4NFU2@976|Bacteroidetes,1HX5C@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate nbaC - 1.13.11.6 ko:K00452 ko00380,ko01100,map00380,map01100 M00038 R02665 RC00387 ko00000,ko00001,ko00002,ko01000 - - - 3-HAO k59_431082_2 1239415.CM001837_gene1161 8.77e-23 92.4 COG2340@1|root,COG2340@2|Bacteria,4NNKS@976|Bacteroidetes,1I1XU@117743|Flavobacteriia,37F6Y@326319|Dokdonia 976|Bacteroidetes S Cysteine-rich secretory protein family - - - - - - - - - - - - CAP k59_267683_1 357276.EL88_23565 5.43e-89 283.0 COG3867@1|root,COG3867@2|Bacteria,4NI3G@976|Bacteroidetes,2FM0Q@200643|Bacteroidia,4ARFR@815|Bacteroidaceae 976|Bacteroidetes G Glycosyl hydrolase family 53 - - 3.2.1.89 ko:K01224 - - - - ko00000,ko01000 - - - Glyco_hydro_53 k59_922602_1 1232437.KL661985_gene3579 1.74e-48 162.0 COG0494@1|root,COG0494@2|Bacteria,1Q5JU@1224|Proteobacteria,42RPC@68525|delta/epsilon subdivisions,2WNUK@28221|Deltaproteobacteria,2MJX1@213118|Desulfobacterales 28221|Deltaproteobacteria L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_922602_2 177437.HRM2_43420 4.78e-37 137.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,42PSQ@68525|delta/epsilon subdivisions,2WKDY@28221|Deltaproteobacteria,2MK85@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2 k59_464997_1 860228.Ccan_13680 2.46e-59 202.0 COG0188@1|root,COG0188@2|Bacteria,4NDWQ@976|Bacteroidetes,1HY4P@117743|Flavobacteriia,1EQR6@1016|Capnocytophaga 976|Bacteroidetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_464997_2 1408473.JHXO01000007_gene858 3.35e-43 158.0 COG0542@1|root,COG0542@2|Bacteria,4NE1J@976|Bacteroidetes,2FNNW@200643|Bacteroidia 976|Bacteroidetes O ATPase family associated with various cellular activities (AAA) clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_497545_1 1123072.AUDH01000011_gene3606 1.8e-41 155.0 COG1574@1|root,COG1574@2|Bacteria,1R53N@1224|Proteobacteria,2VF84@28211|Alphaproteobacteria,2JYNZ@204441|Rhodospirillales 204441|Rhodospirillales S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_366695_1 96561.Dole_0192 5.05e-50 163.0 COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria,2MP9U@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Rieske 2Fe-2S domain pcmE - 1.10.9.1 ko:K02636,ko:K03886 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00151,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - - Rieske k59_366695_2 439235.Dalk_4139 3.96e-28 110.0 COG0746@1|root,COG0746@2|Bacteria,1RKCH@1224|Proteobacteria,42T8X@68525|delta/epsilon subdivisions,2WP3Q@28221|Deltaproteobacteria,2MK7Z@213118|Desulfobacterales 28221|Deltaproteobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_1020136_1 1218352.B597_010250 1.08e-25 99.0 COG1006@1|root,COG1006@2|Bacteria,1RH8H@1224|Proteobacteria,1SA5H@1236|Gammaproteobacteria,1Z313@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria P Multisubunit Na H antiporter, MnhC subunit phaC - 1.6.5.3 ko:K00340,ko:K05560,ko:K05567 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Oxidored_q2 k59_1020136_2 1192034.CAP_7638 8.69e-16 79.3 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,42PD3@68525|delta/epsilon subdivisions,2WJ58@28221|Deltaproteobacteria 28221|Deltaproteobacteria CP PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05561 - - - - ko00000,ko02000 2.A.63.1 - - Proton_antipo_M k59_562976_1 1178825.ALIH01000002_gene1086 6.97e-92 291.0 COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,1HWN8@117743|Flavobacteriia 976|Bacteroidetes C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_758198_1 1123393.KB891327_gene473 3.16e-91 271.0 COG2210@1|root,COG2210@2|Bacteria,1QCK1@1224|Proteobacteria,2WE8S@28216|Betaproteobacteria,1KSAI@119069|Hydrogenophilales 119069|Hydrogenophilales S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_105498_1 929558.SMGD1_0648 1.56e-72 233.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2YM9I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_105498_2 563040.Saut_0585 1.48e-19 86.3 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2YMM9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_497550_1 572544.Ilyop_1381 5.44e-79 243.0 COG0496@1|root,COG0496@2|Bacteria,37BZU@32066|Fusobacteria 32066|Fusobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_497550_2 572544.Ilyop_1380 1.72e-150 431.0 COG2264@1|root,COG2264@2|Bacteria,378I4@32066|Fusobacteria 32066|Fusobacteria J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_497550_3 469618.FVAG_01553 1.76e-89 269.0 COG0283@1|root,COG0283@2|Bacteria,379G2@32066|Fusobacteria 32066|Fusobacteria F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin k59_431103_1 926569.ANT_08580 1.93e-22 102.0 COG2199@1|root,COG2203@1|root,COG3850@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3850@2|Bacteria,2G87Y@200795|Chloroflexi 200795|Chloroflexi T PFAM GGDEF domain containing protein - - - - - - - - - - - - GAF,GAF_2,GGDEF,HisKA_7TM,PAS_4,PAS_8 k59_267701_1 349161.Dred_2956 2.8e-13 69.3 COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia 186801|Clostridia T carbon starvation protein CstA cstA - - - - - - - - - - - CstA,CstA_5TM k59_498308_1 667014.Thein_0540 2.46e-41 154.0 COG0443@1|root,COG0443@2|Bacteria,2GI7E@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O DNA-K related protein - - - - - - - - - - - - DUF3731,HSP70 k59_498308_2 1121405.dsmv_2818 1.38e-45 163.0 COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,42NWU@68525|delta/epsilon subdivisions,2WKQQ@28221|Deltaproteobacteria,2MIBJ@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the heat shock protein 70 family - - - - - - - - - - - - HSP70 k59_628861_1 929558.SMGD1_2397 5.18e-16 76.6 COG0642@1|root,COG4753@1|root,COG2205@2|Bacteria,COG4753@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - EAL,Guanylate_cyc,HATPase_c,HisKA,Pkinase,Response_reg,SpoIIE k59_628861_2 929558.SMGD1_0387 5.39e-84 249.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,42RBS@68525|delta/epsilon subdivisions,2YTD0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT PAS fold - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - PAS_3 k59_628861_3 929558.SMGD1_0386 3.97e-14 72.8 COG0840@1|root,COG0840@2|Bacteria,1N5N4@1224|Proteobacteria,42RSG@68525|delta/epsilon subdivisions,2YRU6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_138972_1 1249627.D779_3356 0.0 1182.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1WW0N@135613|Chromatiales 135613|Chromatiales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_138972_2 105559.Nwat_2174 5.07e-82 245.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1WWE7@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_138972_3 765914.ThisiDRAFT_2609 1.46e-75 226.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,1S3WB@1236|Gammaproteobacteria,1WYAY@135613|Chromatiales 135613|Chromatiales J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_138972_4 1049564.TevJSym_bu00040 0.0 2256.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1J4ZQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_923341_1 690850.Desaf_0189 3.43e-66 221.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,42Q4W@68525|delta/epsilon subdivisions,2WJ9H@28221|Deltaproteobacteria,2MASC@213115|Desulfovibrionales 28221|Deltaproteobacteria I Squalene-hopene cyclase C-terminal domain shc-2 - 4.2.1.129,5.4.99.17,5.4.99.7 ko:K01852,ko:K06045 ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130 M00101 R03199,R07322,R07323 RC00874,RC01850,RC01851 ko00000,ko00001,ko00002,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_857219_2 323261.Noc_1406 1.4e-33 133.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM k59_563644_2 322710.Avin_00170 4.65e-23 93.2 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_661857_1 749222.Nitsa_0245 2.4e-09 57.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2YN5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_661857_2 1165841.SULAR_00125 5.75e-44 148.0 COG3439@1|root,COG3439@2|Bacteria,1REDZ@1224|Proteobacteria,42T1V@68525|delta/epsilon subdivisions,2YPRR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_399719_1 1165841.SULAR_07485 8.73e-135 389.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2YMUH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_923346_1 305700.B447_15981 1.2e-29 108.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2VSE6@28216|Betaproteobacteria,2KWKB@206389|Rhodocyclales 206389|Rhodocyclales J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_923346_2 948565.AFFP02000009_gene604 3.07e-53 174.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1Y74E@135625|Pasteurellales 135625|Pasteurellales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_857227_1 103733.JNYO01000015_gene3562 2.68e-22 101.0 COG1075@1|root,COG1075@2|Bacteria,2HXFM@201174|Actinobacteria 201174|Actinobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - Lipase_2 k59_203720_1 1123377.AUIV01000012_gene741 3.34e-61 206.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1X3X2@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_791010_1 290317.Cpha266_0440 4.42e-63 222.0 COG4772@1|root,COG4772@2|Bacteria,1FD5S@1090|Chlorobi 1090|Chlorobi M TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3 k59_791010_2 1123274.KB899410_gene3456 3.48e-11 65.1 COG0614@1|root,COG0614@2|Bacteria,2J66K@203691|Spirochaetes 203691|Spirochaetes P periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_628879_2 326298.Suden_0847 1.13e-21 91.7 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2YMQJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_203722_1 1141662.OOA_06711 3.14e-42 147.0 COG0558@1|root,COG0558@2|Bacteria,1RE0I@1224|Proteobacteria,1S2UQ@1236|Gammaproteobacteria,3Z8QD@586|Providencia 1236|Gammaproteobacteria I Psort location CytoplasmicMembrane, score ynbA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_628881_1 1278307.KB906976_gene1564 2.54e-69 232.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_824771_1 1408439.JHXW01000003_gene1496 5.09e-124 374.0 COG1200@1|root,COG1200@2|Bacteria,378RT@32066|Fusobacteria 32066|Fusobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_431798_1 1173024.KI912149_gene6429 1.39e-29 121.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G24Y@1117|Cyanobacteria,1JJZM@1189|Stigonemataceae 1117|Cyanobacteria S CHAT domain - - - - - - - - - - - - CHAT,TPR_10,TPR_12,TPR_7,TPR_8 k59_758915_1 525898.Sdel_1501 1.49e-121 377.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,43BP0@68525|delta/epsilon subdivisions,2YTEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LV TaqI-like C-terminal specificity domain - - - - - - - - - - - - N6_Mtase,TaqI_C k59_171350_1 1244083.CSUNSWCD_1846 1.45e-123 375.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,42M8I@68525|delta/epsilon subdivisions,2YN4J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 k59_335184_1 1232437.KL662073_gene1729 5.53e-67 210.0 COG1024@1|root,COG1024@2|Bacteria,1R61Y@1224|Proteobacteria,42P4M@68525|delta/epsilon subdivisions,2WJJU@28221|Deltaproteobacteria,2MIKD@213118|Desulfobacterales 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_628898_1 1396858.Q666_08800 4.8e-66 211.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,465NF@72275|Alteromonadaceae 1236|Gammaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 k59_628898_2 1123253.AUBD01000009_gene2274 4.92e-10 62.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1X3IV@135614|Xanthomonadales 135614|Xanthomonadales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_236388_1 396588.Tgr7_1759 2.06e-123 372.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales 135613|Chromatiales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_535353_1 589865.DaAHT2_0783 2.49e-38 140.0 COG3271@1|root,COG3271@2|Bacteria,1N1ZY@1224|Proteobacteria,43BBJ@68525|delta/epsilon subdivisions 1224|Proteobacteria S Peptidase C39 family - - - ko:K06992 - - - - ko00000 - - - Peptidase_C39 k59_665899_2 1441930.Z042_13375 1.65e-07 51.6 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,40191@613|Serratia 1236|Gammaproteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_4669 UbiD k59_958946_1 1165841.SULAR_10394 1.39e-107 311.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2YMJK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_762636_1 1380763.BG53_10710 6.41e-79 251.0 COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4HCSN@91061|Bacilli,26SYM@186822|Paenibacillaceae 91061|Bacilli G Periplasmic substrate-binding component of the ATP-dependent ribose transport system - - - ko:K17213 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 k59_143295_1 265072.Mfla_1948 6.53e-29 113.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,2VHR3@28216|Betaproteobacteria,2KKUV@206350|Nitrosomonadales 206350|Nitrosomonadales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_697754_1 631362.Thi970DRAFT_04429 2.64e-111 354.0 COG3264@1|root,COG4942@1|root,COG3264@2|Bacteria,COG4942@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X0ES@135613|Chromatiales 135613|Chromatiales DM PFAM Mechanosensitive ion channel - - - - - - - - - - - - MS_channel,MscS_TM,MscS_porin k59_632870_1 768671.ThimaDRAFT_3213 1.41e-98 313.0 COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WW92@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_958957_1 1168289.AJKI01000003_gene2884 3.38e-36 132.0 COG0697@1|root,COG0697@2|Bacteria,4NHQX@976|Bacteroidetes,2FM74@200643|Bacteroidia,3XIX8@558415|Marinilabiliaceae 976|Bacteroidetes EG EamA-like transporter family - - - ko:K08978 - - - - ko00000,ko02000 2.A.7.2 - - EamA k59_927321_1 1121904.ARBP01000033_gene3212 8.74e-42 143.0 COG0702@1|root,COG0702@2|Bacteria,4NGMR@976|Bacteroidetes,47NYS@768503|Cytophagia 976|Bacteroidetes GM epimerase - - - - - - - - - - - - Epimerase k59_927321_2 543632.JOJL01000029_gene3638 1.61e-12 68.2 COG1408@1|root,COG1408@2|Bacteria,2GMST@201174|Actinobacteria,4D8YP@85008|Micromonosporales 201174|Actinobacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_435497_1 926561.KB900622_gene572 7.21e-49 160.0 COG0454@1|root,COG0456@2|Bacteria,1U5Q5@1239|Firmicutes,256YV@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - - k59_435497_3 398579.Spea_1836 3.75e-11 63.5 2C1HY@1|root,33A7C@2|Bacteria,1QDTC@1224|Proteobacteria,1T9XA@1236|Gammaproteobacteria,2QC8I@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_435497_4 1319815.HMPREF0202_00394 2.1e-16 72.8 2ED6X@1|root,3373J@2|Bacteria,37AVF@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_992470_1 1537917.JU82_11230 8.53e-108 328.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2YMKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_697758_1 765911.Thivi_3300 8.31e-94 275.0 COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,1S3TG@1236|Gammaproteobacteria,1X27P@135613|Chromatiales 135613|Chromatiales C Adenosine-5'-phosphosulfate reductase beta subunit - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4_9 k59_7243_1 1168034.FH5T_20965 3.57e-130 380.0 COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,2FMB0@200643|Bacteroidia 976|Bacteroidetes G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos k59_666536_1 1437824.BN940_00451 4.99e-24 93.2 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2VR8I@28216|Betaproteobacteria,3T3GW@506|Alcaligenaceae 28216|Betaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_666536_2 999541.bgla_1g03280 1.3e-45 152.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,1K16Y@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_698333_1 1121367.AQXC01000019_gene1252 8.28e-05 43.5 COG0454@1|root,COG0456@2|Bacteria,2HS9X@201174|Actinobacteria,22QTU@1653|Corynebacteriaceae 201174|Actinobacteria K acetyltransferase - - - - - - - - - - - - - k59_403879_1 153721.MYP_448 7.76e-14 71.6 COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,47KDQ@768503|Cytophagia 976|Bacteroidetes M MBOAT, membrane-bound O-acyltransferase family - - - ko:K19294 - - - - ko00000 - - - MBOAT k59_568122_1 1355374.JARU01000001_gene748 2.07e-10 66.2 COG1373@1|root,COG1373@2|Bacteria,1QP8R@1224|Proteobacteria,42SQ9@68525|delta/epsilon subdivisions,2YPG4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ATPase (AAA - - - ko:K07133 - - - - ko00000 - - - AAA_14 k59_436079_1 1122244.AUGF01000016_gene2217 3.99e-77 245.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,3NJRY@468|Moraxellaceae 1236|Gammaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125 GATase_6,Pribosyltran k59_535855_1 360104.CCC13826_1475 4.99e-13 68.6 COG2171@1|root,COG2171@2|Bacteria,1MYKK@1224|Proteobacteria,42MHI@68525|delta/epsilon subdivisions,2YMU8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep_2,THDPS_M,THDPS_N k59_208704_1 1168034.FH5T_07895 1.24e-83 258.0 COG4942@1|root,COG4942@2|Bacteria,4NH2T@976|Bacteroidetes,2FN4U@200643|Bacteroidia 976|Bacteroidetes D Peptidase, M23 family envC - - - - - - - - - - - Peptidase_M23 k59_176163_1 1123248.KB893359_gene2026 8.04e-23 96.3 COG1218@1|root,COG1218@2|Bacteria,4NFHY@976|Bacteroidetes,1ISXY@117747|Sphingobacteriia 976|Bacteroidetes P COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_633512_1 948106.AWZT01000064_gene1762 7.6e-17 85.5 COG2351@1|root,COG2351@2|Bacteria,1QWX0@1224|Proteobacteria,2WI28@28216|Betaproteobacteria,1KG96@119060|Burkholderiaceae 28216|Betaproteobacteria M hydroxyisourate hydrolase activity - - - - - - - - - - - - - k59_110418_1 981383.AEWH01000035_gene841 2.62e-23 94.7 COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,4HH3B@91061|Bacilli 91061|Bacilli J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_110418_2 272631.ML0364 1.79e-13 69.7 COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,238TI@1762|Mycobacteriaceae 201174|Actinobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_110418_3 1502850.FG91_01588 3.02e-27 104.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,2K4J0@204457|Sphingomonadales 204457|Sphingomonadales J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_110418_4 1125863.JAFN01000001_gene3322 5.4e-56 190.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_403891_1 1168034.FH5T_17730 2.17e-27 110.0 COG0006@1|root,COG0006@2|Bacteria,4NI1J@976|Bacteroidetes,2FNZP@200643|Bacteroidia 976|Bacteroidetes E Belongs to the peptidase M24B family - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C k59_403891_2 1168034.FH5T_17755 1.56e-22 97.8 COG0591@1|root,COG0591@2|Bacteria,4NH7H@976|Bacteroidetes 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307,ko:K14387 ko04725,ko05231,map04725,map05231 - - - ko00000,ko00001,ko02000 2.A.21,2.A.21.8 - - HD_4,SSF k59_305194_1 1049564.TevJSym_ab00900 2.12e-56 178.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam Rhodanese-like - - - - - - - - - - - - Rhodanese k59_305194_2 765912.Thimo_0111 2.03e-27 108.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,1WVUP@135613|Chromatiales 135613|Chromatiales M Lipid A biosynthesis acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_503395_2 330214.NIDE1348 5.27e-36 142.0 COG4972@1|root,COG4972@2|Bacteria,3J177@40117|Nitrospirae 40117|Nitrospirae NU Type IV pilus assembly protein PilM; - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_1024839_1 879212.DespoDRAFT_01638 9.1e-45 152.0 COG5340@1|root,COG5340@2|Bacteria,1RGNP@1224|Proteobacteria,42UD1@68525|delta/epsilon subdivisions,2WQPR@28221|Deltaproteobacteria,2MM9V@213118|Desulfobacterales 28221|Deltaproteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_1024839_2 870187.Thini_4237 9.9e-132 382.0 COG2253@1|root,COG2253@2|Bacteria,1R3R3@1224|Proteobacteria,1S0PT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_927940_1 871963.Desdi_1707 9.07e-13 74.7 COG1397@1|root,COG1397@2|Bacteria,1V02G@1239|Firmicutes,24CS9@186801|Clostridia 186801|Clostridia O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_371852_1 326298.Suden_0736 2.83e-90 281.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,42MQD@68525|delta/epsilon subdivisions,2YNN1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sulfate permease - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_272147_4 572544.Ilyop_0709 1.62e-26 107.0 COG0531@1|root,COG0531@2|Bacteria,379SQ@32066|Fusobacteria 32066|Fusobacteria E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_959610_1 765911.Thivi_3064 1.4e-20 95.9 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales 135613|Chromatiales O TIGRFAM Cytochrome c-type biogenesis protein CcmI - - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_176172_1 640513.Entas_2043 2.16e-103 350.0 COG0457@1|root,COG2373@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG0457@2|Bacteria,COG2373@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q von willebrand factor, type A lapA - - ko:K12549 - - - - ko00000 - - - Big_3_2,Cadherin_3,Calx-beta,HemolysinCabind,VCBS,VWA,VWA_2 k59_959613_1 388051.AUFE01000056_gene4865 2.13e-69 236.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_568148_1 411684.HPDFL43_03189 6.81e-14 69.7 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,43INJ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_568148_2 935548.KI912159_gene5939 4.8e-33 115.0 COG0636@1|root,COG0636@2|Bacteria,1MZBU@1224|Proteobacteria,2UFPN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_208738_1 1280390.CBQR020000100_gene2335 1.47e-65 206.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,4HAVS@91061|Bacilli,26R6G@186822|Paenibacillaceae 91061|Bacilli J Belongs to the pseudouridine synthase RsuA family rluF - 5.4.99.21 ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_730166_1 1121468.AUBR01000010_gene2458 1.13e-56 180.0 COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,42G3R@68295|Thermoanaerobacterales 186801|Clostridia E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_633549_1 1227349.C170_01149 3.87e-11 68.2 COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,4HMI2@91061|Bacilli,26TGA@186822|Paenibacillaceae 91061|Bacilli N transport system involved in gliding motility, auxiliary component gldG - - - - - - - - - - - ABC_transp_aux k59_959633_1 1123399.AQVE01000005_gene947 2.37e-24 93.2 COG2442@1|root,COG2442@2|Bacteria,1NH5R@1224|Proteobacteria,1SH9A@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF433) - - - - - - - - - - - - DUF433 k59_666595_1 929558.SMGD1_1248 3.6e-89 271.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2YM9J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_763369_1 546269.HMPREF0389_01470 1.2e-132 379.0 COG2057@1|root,COG2057@2|Bacteria,1UDE4@1239|Firmicutes,24B51@186801|Clostridia,25SDZ@186804|Peptostreptococcaceae 186801|Clostridia I Coenzyme A transferase gctB - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_763369_2 546269.HMPREF0389_01469 1.53e-110 326.0 COG1788@1|root,COG1788@2|Bacteria,1UYH2@1239|Firmicutes,24CPB@186801|Clostridia,25S21@186804|Peptostreptococcaceae 186801|Clostridia I Coenzyme A transferase gctA - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_403932_1 1168034.FH5T_17545 1.09e-66 203.0 2CT4B@1|root,32SSJ@2|Bacteria,4NQ76@976|Bacteroidetes,2FUCD@200643|Bacteroidia 976|Bacteroidetes K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - - - - - - - - - - - RNA_pol_Rpb6 k59_403932_2 266762.HQ36_01375 9.16e-18 82.0 COG0452@1|root,COG0452@2|Bacteria,4NE46@976|Bacteroidetes,2FNDG@200643|Bacteroidia,22X4T@171551|Porphyromonadaceae 976|Bacteroidetes H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_7652_1 742159.HMPREF0004_5165 5.19e-53 179.0 COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2VHM1@28216|Betaproteobacteria 28216|Betaproteobacteria EQ PFAM peptidase S58, DmpA - - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 k59_436135_1 1227360.C176_02403 6.68e-10 62.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,4H9TI@91061|Bacilli,26DVU@186818|Planococcaceae 91061|Bacilli I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:0090407,GO:1901576 - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_600911_1 933262.AXAM01000151_gene828 4.81e-74 239.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales 28221|Deltaproteobacteria S pfam abc-1 - - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_698397_1 1249627.D779_1382 3.21e-96 292.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales 135613|Chromatiales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_1024885_1 457412.RSAG_01672 1.03e-47 161.0 COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,3WIZU@541000|Ruminococcaceae 186801|Clostridia S B12 binding domain - - - - - - - - - - - - B12-binding,B12-binding_2 k59_1024887_1 314345.SPV1_08456 2.69e-99 308.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria 1224|Proteobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - - - - - - - - - - - XFP,XFP_N k59_698399_2 387093.SUN_0597 4.57e-39 138.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2YMT4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_633574_1 933262.AXAM01000004_gene2359 3.09e-65 215.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,42PTE@68525|delta/epsilon subdivisions,2WKRZ@28221|Deltaproteobacteria,2MIH0@213118|Desulfobacterales 28221|Deltaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO k59_110461_2 697282.Mettu_4051 2.18e-72 232.0 COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,1RQVD@1236|Gammaproteobacteria,1XG2K@135618|Methylococcales 135618|Methylococcales P Citrate transporter - - - - - - - - - - - - CitMHS k59_240669_1 1408324.JNJK01000005_gene972 0.000175 45.1 COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,27RA1@186928|unclassified Lachnospiraceae 186801|Clostridia T FIST C domain - - - - - - - - - - - - FIST,FIST_C,HATPase_c,HisKA,Hpt,MASE3,Response_reg k59_993144_1 1042377.AFPJ01000004_gene353 7.89e-85 270.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,464KP@72275|Alteromonadaceae 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold nfdA_2 - - - - - - - - - - - Amidohydro_3 k59_43120_1 71139.XP_010049700.1 4.04e-06 52.8 COG5078@1|root,KOG0417@2759|Eukaryota,37QGG@33090|Viridiplantae,3G8M8@35493|Streptophyta 35493|Streptophyta O Belongs to the ubiquitin-conjugating enzyme family - GO:0000209,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0019899,GO:0031625,GO:0032446,GO:0033554,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0061630,GO:0061659,GO:0070647,GO:0071704,GO:0140096,GO:1901564 2.3.2.23 ko:K13960 ko03460,map03460 - - - ko00000,ko00001,ko01000,ko03400,ko04121 - - - UQ_con k59_43120_3 575540.Isop_1342 1.64e-40 157.0 COG0476@1|root,COG0476@2|Bacteria,2IY9K@203682|Planctomycetes 203682|Planctomycetes H PFAM UBA THIF-type NAD FAD binding protein - - - - - - - - - - - - ThiF k59_993146_1 1165841.SULAR_04402 4.1e-83 251.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2YMGA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_793831_1 1123502.AQXD01000003_gene1537 1.47e-97 294.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1X32I@135614|Xanthomonadales 135614|Xanthomonadales E Acetylglutamate kinase argB GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.7.2.8 ko:K22478 ko00220,ko01210,ko01230,map00220,map01210,map01230 M00028,M00845 R00259,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,NAT k59_793831_2 929506.CbC4_2139 0.0 1447.0 COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,36DIP@31979|Clostridiaceae 186801|Clostridia F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_793831_3 536227.CcarbDRAFT_4940 6.93e-162 464.0 COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,36DTQ@31979|Clostridiaceae 186801|Clostridia F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_793831_4 697329.Rumal_2074 5.15e-13 68.6 COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,3WGSI@541000|Ruminococcaceae 186801|Clostridia E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_829156_1 765912.Thimo_0243 3.35e-114 347.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WZYZ@135613|Chromatiales 135613|Chromatiales C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_503472_1 765910.MARPU_06360 2.78e-98 317.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_993151_1 550540.Fbal_0457 3.39e-11 62.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RYVY@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit - - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_998423_1 1469557.JSWF01000025_gene1389 5.43e-59 194.0 COG1207@1|root,COG1207@2|Bacteria,4NDZP@976|Bacteroidetes,1HWW0@117743|Flavobacteriia 976|Bacteroidetes M glucose-1-phosphate thymidylyltransferase glmU - - - - - - - - - - - NTP_transf_4 k59_573320_1 572544.Ilyop_1474 5.16e-88 285.0 COG0553@1|root,COG0553@2|Bacteria,3788I@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Helicase_C,SNF2_N k59_998424_1 1121405.dsmv_2629 5.42e-89 279.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MHYG@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM malic - - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_12084_1 929558.SMGD1_0642 8.09e-91 290.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2YMJY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1g k59_181826_1 240015.ACP_0020 1.53e-05 49.3 COG1472@1|root,COG1472@2|Bacteria,3Y3M7@57723|Acidobacteria,2JKHP@204432|Acidobacteriia 204432|Acidobacteriia G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_181828_1 1232410.KI421425_gene1550 4.78e-84 268.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_573328_1 1249480.B649_10895 1.96e-105 311.0 COG0602@1|root,COG0602@2|Bacteria,1PDNI@1224|Proteobacteria,42R24@68525|delta/epsilon subdivisions,2YN2N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14 k59_573328_2 1346330.M472_19230 3.26e-36 126.0 COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1IU6R@117747|Sphingobacteriia 976|Bacteroidetes J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_573328_3 1249480.B649_10900 3.34e-64 204.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2YM8U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_1029923_2 1141662.OOA_18269 1.47e-14 79.3 COG3306@1|root,COG3306@2|Bacteria,1PG6V@1224|Proteobacteria,1RWDJ@1236|Gammaproteobacteria,3ZAEY@586|Providencia 1236|Gammaproteobacteria M Glycosyltransferase family 25 (LPS biosynthesis protein) - - - - - - - - - - - - Glyco_transf_25 k59_82579_1 439235.Dalk_4133 1.25e-13 73.9 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MJ96@213118|Desulfobacterales 28221|Deltaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_82586_1 243365.CV_1359 7.58e-29 109.0 COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,2KR4C@206351|Neisseriales 206351|Neisseriales S Psort location CytoplasmicMembrane, score 9.46 - - - - - - - - - - - - UPF0016 k59_866598_1 413404.Rmag_0543 5.01e-29 114.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1J5F5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_606455_2 1454007.JAUG01000029_gene3199 5.33e-45 167.0 COG1435@1|root,COG1435@2|Bacteria,4NE0A@976|Bacteroidetes,1IQAB@117747|Sphingobacteriia 976|Bacteroidetes F PFAM RagB SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_541298_1 1249480.B649_10890 1.32e-86 258.0 COG0720@1|root,COG0720@2|Bacteria,1R62M@1224|Proteobacteria,42R4Z@68525|delta/epsilon subdivisions,2YNZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_638886_1 983548.Krodi_2834 6.12e-43 155.0 COG0366@1|root,COG0366@2|Bacteria,4NIGP@976|Bacteroidetes,1I061@117743|Flavobacteriia,37EKE@326319|Dokdonia 976|Bacteroidetes G Alpha amylase catalytic - - 2.4.1.7 ko:K00690 ko00500,map00500 - R00803 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase k59_638886_2 765911.Thivi_3354 3.13e-11 62.0 COG4322@1|root,COG4322@2|Bacteria,1R4WQ@1224|Proteobacteria,1SZ11@1236|Gammaproteobacteria,1WX5W@135613|Chromatiales 135613|Chromatiales S Uncharacterized protein conserved in bacteria (DUF2272) - - - - - - - - - - - - DUF2272 k59_310646_2 2340.JV46_19800 4.37e-35 129.0 COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,1RRQ5@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Helix-hairpin-helix domain - - - ko:K04477 - - - - ko00000 - - - HHH_5,HHH_8 k59_115579_1 504472.Slin_0308 1.94e-48 171.0 COG3669@1|root,COG3669@2|Bacteria,4NEDX@976|Bacteroidetes,47JNA@768503|Cytophagia 976|Bacteroidetes G Coagulation factor 5 8 type domain protein - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,F5_F8_type_C k59_115579_2 498211.CJA_3593 7.87e-27 110.0 COG1554@1|root,COG1554@2|Bacteria,1NZ6Z@1224|Proteobacteria,1T320@1236|Gammaproteobacteria,1FG13@10|Cellvibrio 1236|Gammaproteobacteria G Glycosyl hydrolase family 65, N-terminal domain - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2 k59_441452_1 1121405.dsmv_1308 4.47e-88 263.0 COG1309@1|root,COG1309@2|Bacteria,1R7QV@1224|Proteobacteria,43AFI@68525|delta/epsilon subdivisions,2WINE@28221|Deltaproteobacteria,2MJ31@213118|Desulfobacterales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_998459_1 290317.Cpha266_2328 3.44e-31 123.0 COG1924@1|root,COG1924@2|Bacteria 2|Bacteria I 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_48149_1 886379.AEWI01000208_gene2427 1.51e-70 232.0 COG1509@1|root,COG1509@2|Bacteria,4NJ79@976|Bacteroidetes,2G2FM@200643|Bacteroidia,3XJK2@558415|Marinilabiliaceae 976|Bacteroidetes E Lysine-2,3-aminomutase ablA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_573361_1 32024.JMTI01000020_gene449 2.3e-38 147.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,43AE2@68525|delta/epsilon subdivisions 1224|Proteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,HAMP k59_573361_2 203119.Cthe_0601 6.36e-17 80.9 COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,3WJ1D@541000|Ruminococcaceae 186801|Clostridia H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_798275_1 1537915.JU57_09970 1.47e-49 173.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2YMQT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the peptidase S1C family htrA - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_703867_1 335543.Sfum_1583 1.16e-53 173.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,2MQIR@213462|Syntrophobacterales 28221|Deltaproteobacteria J PFAM ribosomal protein L17 rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_672091_1 1168034.FH5T_13605 1.9e-110 339.0 COG1048@1|root,COG1048@2|Bacteria,4NDZT@976|Bacteroidetes,2FMDQ@200643|Bacteroidia 976|Bacteroidetes C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_933135_1 945713.IALB_1419 1.21e-64 210.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_82612_1 382464.ABSI01000012_gene2198 5.1e-50 181.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C k59_1029946_1 1121405.dsmv_3388 1.26e-128 384.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,2MHVX@213118|Desulfobacterales 28221|Deltaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_441463_1 1168034.FH5T_21125 3.98e-52 172.0 COG2068@1|root,COG2068@2|Bacteria,4NQNF@976|Bacteroidetes 976|Bacteroidetes S MobA-related protein - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_769021_2 518766.Rmar_0553 3.39e-16 76.3 COG2065@1|root,COG2065@2|Bacteria,4NFI1@976|Bacteroidetes,1FJ7P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_735392_1 485913.Krac_7649 3.47e-08 54.7 COG0818@1|root,COG0818@2|Bacteria,2G75I@200795|Chloroflexi 200795|Chloroflexi M PFAM diacylglycerol kinase - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_115604_1 344747.PM8797T_21028 1.76e-05 52.8 COG1520@1|root,COG1864@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG5492@1|root,COG1520@2|Bacteria,COG1864@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,COG5492@2|Bacteria,2IY9M@203682|Planctomycetes 203682|Planctomycetes Q DNA RNA non-specific endonuclease - - - - - - - - - - - - - k59_345563_2 1249997.JHZW01000003_gene2110 1.01e-12 68.9 COG1266@1|root,COG1266@2|Bacteria,4NHRW@976|Bacteroidetes,1I1CE@117743|Flavobacteriia 976|Bacteroidetes S Abortive infection protein - - - ko:K07052 - - - - ko00000 - - - Abi k59_277185_1 1223521.BBJX01000007_gene1539 4.31e-81 251.0 COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2VHIM@28216|Betaproteobacteria,4ABP6@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Ornithine cyclodeaminase mu-crystallin arcB - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_82629_1 326298.Suden_1529 3.43e-38 131.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2YP0K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_82629_2 794903.OPIT5_18600 6.57e-06 53.9 COG0767@1|root,COG0767@2|Bacteria,46SY3@74201|Verrucomicrobia,3K73N@414999|Opitutae 414999|Opitutae Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_509145_1 644801.Psest_2158 6.57e-96 300.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria,1Z1GX@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_509150_1 1168034.FH5T_07275 3.92e-111 325.0 28H74@1|root,2Z7JF@2|Bacteria,4NFR0@976|Bacteroidetes,2FQ0B@200643|Bacteroidia 976|Bacteroidetes S Gliding motility-associated protein GldN gldN - - - - - - - - - - - - k59_638912_1 246200.SPO3036 4.04e-119 361.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4ND2Q@97050|Ruegeria 28211|Alphaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_834437_1 502025.Hoch_1575 8.18e-59 195.0 2DBF7@1|root,2Z8X0@2|Bacteria,1QXU4@1224|Proteobacteria,42YFE@68525|delta/epsilon subdivisions,2WTQD@28221|Deltaproteobacteria,2YUC6@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - Chlam_PMP k59_377029_1 439235.Dalk_4831 1.99e-67 224.0 COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales 28221|Deltaproteobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_441492_2 765914.ThisiDRAFT_1391 3.81e-31 118.0 COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,1RNMT@1236|Gammaproteobacteria,1WXIM@135613|Chromatiales 135613|Chromatiales P PFAM Ion transport - - - ko:K08714 - - - - ko00000,ko02000 1.A.1.14 - - Ion_trans k59_736030_2 1540257.JQMW01000013_gene988 8.65e-72 222.0 COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,36FWE@31979|Clostridiaceae 186801|Clostridia C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queH - 1.17.99.6 ko:K09765 - - - - ko00000,ko01000,ko03016 - - - DUF208 k59_799146_1 314345.SPV1_03473 1.59e-68 217.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria 1224|Proteobacteria T radical SAM - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_182537_1 1230342.CTM_06771 6.53e-49 161.0 COG0701@1|root,COG0701@2|Bacteria,1V51D@1239|Firmicutes,25DXC@186801|Clostridia,36UFW@31979|Clostridiaceae 186801|Clostridia S Predicted permease - - - - - - - - - - - - ArsP_1 k59_182537_2 1304284.L21TH_0817 2.08e-06 50.1 COG0701@1|root,COG0701@2|Bacteria,1UZ6Z@1239|Firmicutes,25DX2@186801|Clostridia,36UFT@31979|Clostridiaceae 186801|Clostridia S Predicted permease - - - - - - - - - - - - ArsP_1,Fer4_13 k59_607188_1 4081.Solyc01g007340.2.1 6.34e-232 650.0 COG4799@1|root,KOG0540@2759|Eukaryota,37NPW@33090|Viridiplantae,3GG0Z@35493|Streptophyta,44QTN@71274|asterids 35493|Streptophyta H Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963,ko:K02696 ko00061,ko00195,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00195,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko00194,ko01000 - - - Carboxyl_trans,PSI_8 k59_442103_1 269799.Gmet_2427 3.06e-48 174.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,43S4S@69541|Desulfuromonadales 28221|Deltaproteobacteria T Signal transducing histidine kinase homodimeric cheA34H - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_999276_1 439235.Dalk_0551 1.06e-41 150.0 COG0392@1|root,COG0392@2|Bacteria,1R98C@1224|Proteobacteria,42U6V@68525|delta/epsilon subdivisions,2WKTZ@28221|Deltaproteobacteria,2MJCJ@213118|Desulfobacterales 28221|Deltaproteobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_999276_2 1121405.dsmv_2773 9.84e-28 108.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,2MHYE@213118|Desulfobacterales 28221|Deltaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_799154_1 537013.CLOSTMETH_01912 5.17e-24 108.0 COG1538@1|root,COG3250@1|root,COG1538@2|Bacteria,COG3250@2|Bacteria,1V1D9@1239|Firmicutes,24H7I@186801|Clostridia 2|Bacteria G Psort location - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C,FIVAR,Glyco_hydro_106,Glyco_hydro_2_N,OEP k59_12859_1 521097.Coch_0377 3.68e-32 128.0 COG2755@1|root,COG2755@2|Bacteria,4NHT6@976|Bacteroidetes,1HYAV@117743|Flavobacteriia,1EQ6J@1016|Capnocytophaga 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL,Lipase_GDSL_2 k59_965993_1 572546.Arcpr_0792 1.59e-07 58.2 COG0642@1|root,COG1241@1|root,COG1372@1|root,arCOG03146@1|root,arCOG03155@1|root,arCOG00439@2157|Archaea,arCOG03145@2157|Archaea,arCOG03146@2157|Archaea,arCOG03155@2157|Archaea,arCOG03158@2157|Archaea,arCOG06408@2157|Archaea,2XT5D@28890|Euryarchaeota,246MK@183980|Archaeoglobi 183980|Archaeoglobi L Mcm family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_OB k59_509899_1 402626.Rpic_3117 1.21e-56 188.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria,1K11N@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) paaK - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_509899_2 1500304.JQKY01000019_gene612 7.18e-52 167.0 COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,2U5QW@28211|Alphaproteobacteria,4BDYI@82115|Rhizobiaceae 28211|Alphaproteobacteria Q Thioesterase superfamily paaD - - ko:K02614 ko00360,map00360 - R09840 RC00004,RC00014 ko00000,ko00001,ko01000 - - - 4HBT k59_639739_1 439235.Dalk_1090 1.3e-13 71.2 COG2197@1|root,COG2197@2|Bacteria,1R4BK@1224|Proteobacteria,42NQ2@68525|delta/epsilon subdivisions,2WJ35@28221|Deltaproteobacteria,2MJ46@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_639739_2 498211.CJA_3624 2.42e-06 48.9 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1FG62@10|Cellvibrio 1236|Gammaproteobacteria S Bacterial transferase hexapeptide (six repeats) yrdA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840 - - - - - - - - - - Hexapep k59_541861_1 1249627.D779_0448 3.73e-29 105.0 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,1WZ9Q@135613|Chromatiales 135613|Chromatiales J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_541861_2 1049564.TevJSym_aa02310 1.53e-227 634.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1J4D1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_541861_3 1049564.TevJSym_aa02290 0.0 1250.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_541861_4 985665.HPL003_24430 1.34e-45 161.0 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,26SUS@186822|Paenibacillaceae 91061|Bacilli T serine threonine protein phosphatase stp - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_541861_5 197221.22295053 1.1e-06 58.2 COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1G102@1117|Cyanobacteria 1117|Cyanobacteria V ABC-type multidrug transport system ATPase component - - - - - - - - - - - - ABC2_membrane,ABC_tran,FHA k59_541861_6 2340.JV46_28730 1.61e-31 117.0 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1J6PC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Modulates RecA activity recX GO:0003674,GO:0005488,GO:0005515,GO:0006282,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0071496,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020 - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_541861_7 2340.JV46_28720 1.03e-201 564.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1J536@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006928,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0040011,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_541861_8 472759.Nhal_1117 6.86e-52 171.0 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SCZX@1236|Gammaproteobacteria,1WZ3C@135613|Chromatiales 135613|Chromatiales J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_541861_9 3659.XP_004170042.1 1.3e-76 273.0 COG3914@1|root,KOG4626@2759|Eukaryota,37IV9@33090|Viridiplantae,3G9DX@35493|Streptophyta,4JNJN@91835|fabids 35493|Streptophyta GOT UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase SPY GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0007154,GO:0007165,GO:0008150,GO:0008194,GO:0008375,GO:0009719,GO:0009725,GO:0009735,GO:0009736,GO:0009739,GO:0009740,GO:0009755,GO:0009937,GO:0009938,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010476,GO:0010646,GO:0010648,GO:0016262,GO:0016740,GO:0016757,GO:0016758,GO:0019222,GO:0023051,GO:0023052,GO:0023057,GO:0031323,GO:0032870,GO:0033993,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071310,GO:0071368,GO:0071370,GO:0071396,GO:0071495,GO:0140096,GO:1901700,GO:1901701,GO:2000377 - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_10,TPR_16,TPR_7,TPR_8 k59_541861_10 1283300.ATXB01000001_gene308 6.86e-51 167.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,1XF9S@135618|Methylococcales 135618|Methylococcales S Belongs to the CinA family - - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_541861_11 118163.Ple7327_3451 5.79e-47 152.0 COG3450@1|root,COG3450@2|Bacteria,1G7YR@1117|Cyanobacteria,3VMXP@52604|Pleurocapsales 1117|Cyanobacteria S enzyme of the cupin superfamily - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_541861_12 1249627.D779_1671 0.0 1129.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_382911_2 1537917.JU82_06710 2.23e-27 108.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42R7E@68525|delta/epsilon subdivisions,2YNXU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,Omptin k59_804438_1 1165841.SULAR_09054 1.44e-125 373.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2YMR5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_612538_1 555779.Dthio_PD1842 1.55e-66 227.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2M8T9@213115|Desulfovibrionales 28221|Deltaproteobacteria I ATPase BadF BadG BcrA BcrD type - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_18365_1 768671.ThimaDRAFT_0300 5.66e-76 244.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1WW0B@135613|Chromatiales 135613|Chromatiales P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_612541_1 1232410.KI421426_gene1474 6.78e-22 100.0 COG3264@1|root,COG3264@2|Bacteria,1QUDC@1224|Proteobacteria,43DHA@68525|delta/epsilon subdivisions,2X8P3@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_612541_2 314345.SPV1_03538 6.58e-06 47.4 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria 1224|Proteobacteria E alanine symporter alsT - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_678316_1 572544.Ilyop_0301 2.88e-18 83.6 COG1966@1|root,COG1966@2|Bacteria,3786J@32066|Fusobacteria 32066|Fusobacteria T Carbon starvation protein CstA - - - - - - - - - - - - CstA,CstA_5TM k59_351592_1 1144275.COCOR_01446 3.44e-79 254.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2YZUW@29|Myxococcales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_906088_1 1249627.D779_3023 4.13e-120 356.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_906088_3 227377.CBU_0468 1.75e-08 52.0 COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,1JF8E@118969|Legionellales 118969|Legionellales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_939043_1 869213.JCM21142_41533 2.56e-83 269.0 COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,47MRY@768503|Cytophagia 976|Bacteroidetes C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_447554_1 380358.XALC_1058 4.74e-39 148.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1X3AB@135614|Xanthomonadales 135614|Xanthomonadales Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_382927_2 1049564.TevJSym_at00310 1.53e-53 186.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RYF4@1236|Gammaproteobacteria,1J8MZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria GM Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_2 k59_515378_1 1123518.ARWI01000001_gene964 2.69e-74 244.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,45ZWF@72273|Thiotrichales 72273|Thiotrichales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_18375_1 404589.Anae109_2549 2.97e-22 95.1 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WRZW@28221|Deltaproteobacteria,2YWS5@29|Myxococcales 28221|Deltaproteobacteria O Peptidyl-prolyl cis-trans slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_645095_1 694427.Palpr_0352 2.7e-28 116.0 COG1506@1|root,COG1506@2|Bacteria,4PN2U@976|Bacteroidetes 976|Bacteroidetes E peptidase - - - - - - - - - - - - - k59_88882_1 929558.SMGD1_0166 6.68e-92 278.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2YMQJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_252193_1 1165841.SULAR_03332 6.11e-58 198.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - ko:K07184 - - - - ko00000 - - - DUF3488,Transglut_core k59_645102_1 1168034.FH5T_01025 9.63e-40 144.0 COG1070@1|root,COG1070@2|Bacteria,4NE3S@976|Bacteroidetes 976|Bacteroidetes G Carbohydrate kinase - - - - - - - - - - - - FGGY_N k59_645102_2 435591.BDI_2624 1.33e-20 89.4 COG1082@1|root,COG1082@2|Bacteria,4NFQY@976|Bacteroidetes,2FWU9@200643|Bacteroidia,22ZRC@171551|Porphyromonadaceae 976|Bacteroidetes G Xylose isomerase domain protein TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_741383_1 159087.Daro_0049 1.47e-14 78.6 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2VHTW@28216|Betaproteobacteria,2KUCA@206389|Rhodocyclales 206389|Rhodocyclales EGP drug resistance transporter - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_515396_1 1049564.TevJSym_ad01120 5.07e-111 353.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1J5AR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_220436_1 1349822.NSB1T_13715 1.42e-14 72.4 COG2869@1|root,COG2869@2|Bacteria,4NF7A@976|Bacteroidetes,2FMQM@200643|Bacteroidia,22XWP@171551|Porphyromonadaceae 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_220436_2 1168034.FH5T_21810 9.59e-50 169.0 COG4658@1|root,COG4658@2|Bacteria,4NFGW@976|Bacteroidetes,2FMD0@200643|Bacteroidia 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_515398_1 1157490.EL26_14810 1.26e-74 234.0 COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,4H9NS@91061|Bacilli,27854@186823|Alicyclobacillaceae 91061|Bacilli G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapB GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016491,GO:0016620,GO:0016903,GO:0019318,GO:0019319,GO:0036094,GO:0043891,GO:0044238,GO:0044281,GO:0044283,GO:0046364,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_906107_1 1183438.GKIL_0575 1.01e-87 281.0 COG1215@1|root,COG1215@2|Bacteria,1G1PY@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Glycosyl transferase family 2 - - 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Glyco_tranf_2_3,Glycos_transf_2 k59_316681_1 876044.IMCC3088_1441 1.45e-16 82.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1J4H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HflC and HflK could encode or regulate a protease hflK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_122673_1 1307761.L21SP2_0276 9.39e-42 162.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6WY@203691|Spirochaetes 203691|Spirochaetes C Iron only hydrogenase large subunit, C-terminal domain hymC - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3 k59_122673_2 338963.Pcar_0915 5.09e-57 182.0 2DDNA@1|root,2ZIND@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_122673_3 338963.Pcar_0914 1.4e-263 734.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.12.1.3,1.6.5.2,1.6.5.3 ko:K00124,ko:K00335,ko:K00355,ko:K18331 ko00130,ko00190,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,ko05200,ko05225,ko05418,map00130,map00190,map00630,map00680,map01100,map01110,map01120,map01200,map05200,map05225,map05418 M00144 R00519,R02964,R03643,R03816,R11945 RC00061,RC00819,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_906810_2 572544.Ilyop_1883 3.22e-123 360.0 COG0765@1|root,COG0765@2|Bacteria,37A91@32066|Fusobacteria 32066|Fusobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_906810_3 572544.Ilyop_1884 4.88e-113 331.0 COG1126@1|root,COG1126@2|Bacteria,37A4R@32066|Fusobacteria 32066|Fusobacteria E AAA domain, putative AbiEii toxin, Type IV TA system - - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_156381_1 1121013.P873_09870 1.69e-49 165.0 COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,1S0J9@1236|Gammaproteobacteria,1X3D8@135614|Xanthomonadales 135614|Xanthomonadales U Involved in the import of queuosine (Q) precursors, required for Q precursor salvage - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_156381_2 1049564.TevJSym_av00380 3.61e-32 124.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1J7ED@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG1459 Type II secretory pathway, component PulF lspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_841286_1 1232437.KL662072_gene1802 3.2e-115 354.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MJFX@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain pcmT - 1.17.1.4,1.3.7.9 ko:K00087,ko:K04108 ko00230,ko00362,ko00627,ko01100,ko01120,ko01220,map00230,map00362,map00627,map01100,map01120,map01220 M00546 R01768,R02103,R05316 RC00143,RC00490 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 k59_1036865_1 583355.Caka_2618 1.26e-81 256.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_805360_1 1168034.FH5T_18970 3.39e-25 99.8 2EGII@1|root,33AAP@2|Bacteria,4NXMZ@976|Bacteroidetes,2FVPI@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - DUF4890 k59_646103_1 572544.Ilyop_0806 9.87e-162 455.0 COG1208@1|root,COG1208@2|Bacteria,378WP@32066|Fusobacteria 32066|Fusobacteria M Nucleotidyl transferase - - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_646103_2 1385511.N783_13530 9.65e-178 500.0 COG0451@1|root,COG0451@2|Bacteria,1TQV2@1239|Firmicutes,4HBXU@91061|Bacilli 91061|Bacilli GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_646103_3 1385511.N783_13525 2.16e-161 459.0 COG1089@1|root,COG1089@2|Bacteria 2|Bacteria M GDP-mannose 4,6-dehydratase activity gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_284074_2 765911.Thivi_3437 3.23e-13 66.2 2ANXM@1|root,31DYF@2|Bacteria,1RICP@1224|Proteobacteria,1S66S@1236|Gammaproteobacteria,1WYJB@135613|Chromatiales 135613|Chromatiales S Phasin protein - - - - - - - - - - - - Phasin_2 k59_352467_1 1168034.FH5T_17100 3.42e-90 281.0 COG2070@1|root,COG2070@2|Bacteria,4NEGW@976|Bacteroidetes 976|Bacteroidetes S 2-Nitropropane dioxygenase - - - - - - - - - - - - - k59_253030_1 1232437.KL662020_gene789 1.8e-80 253.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,42QG6@68525|delta/epsilon subdivisions,2WNNB@28221|Deltaproteobacteria,2MQ3G@213118|Desulfobacterales 28221|Deltaproteobacteria V MatE norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_448698_1 1288494.EBAPG3_4450 4.79e-45 156.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2VKAU@28216|Betaproteobacteria,372AN@32003|Nitrosomonadales 28216|Betaproteobacteria P TIGRFAM phosphate binding protein pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like,PBP_like_2 k59_939924_1 1265502.KB905932_gene1848 3.23e-116 344.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,4AD8Y@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the DegT DnrJ EryC1 family bplF - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_776081_1 1168034.FH5T_05595 3.71e-89 271.0 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,2FME3@200643|Bacteroidia 976|Bacteroidetes M Peptidase, M23 - - - - - - - - - - - - Peptidase_M23 k59_516550_1 572544.Ilyop_1078 5.97e-74 237.0 COG0369@1|root,COG1151@2|Bacteria 2|Bacteria C hydroxylamine reductase activity hcp GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - iAF987.Gmet_2834 Prismane k59_805378_1 90813.JQMT01000001_gene2101 2.65e-91 293.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,45ZT1@72273|Thiotrichales 72273|Thiotrichales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_580252_2 1123360.thalar_02883 2.79e-13 64.3 2ERCE@1|root,33IY3@2|Bacteria,1NNN9@1224|Proteobacteria,2UXY5@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_580252_3 1244869.H261_01552 2.39e-05 45.1 COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2UJSY@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome c oxidase (Subunit II) - - - - - - - - - - - - - k59_448714_2 596151.DesfrDRAFT_0963 9.03e-16 78.6 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42QQC@68525|delta/epsilon subdivisions,2X5E7@28221|Deltaproteobacteria,2M8TN@213115|Desulfovibrionales 28221|Deltaproteobacteria T TIGRFAM Diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg k59_481253_1 240015.ACP_2090 2.68e-81 252.0 COG0604@1|root,COG0604@2|Bacteria,3Y6US@57723|Acidobacteria,2JK9I@204432|Acidobacteriia 204432|Acidobacteriia C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_580255_1 153948.NAL212_0013 3.05e-94 280.0 COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VSUV@28216|Betaproteobacteria 28216|Betaproteobacteria L ISXO2-like transposase domain - - - ko:K07488 - - - - ko00000 - - - DDE_Tnp_IS1595 k59_679271_2 387093.SUN_0445 1.25e-36 132.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2YMIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LU DNA processing protein dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_416035_1 335543.Sfum_0813 1.43e-97 298.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,42N09@68525|delta/epsilon subdivisions,2WIRX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_710946_1 34007.IT40_14780 1.47e-33 123.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,2PW7R@265|Paracoccus 28211|Alphaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_710946_2 1105367.CG50_00240 7.16e-65 203.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_580261_1 713586.KB900536_gene2967 3.44e-111 347.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_580261_2 998088.B565_0561 6.64e-51 171.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1Y3F2@135624|Aeromonadales 135624|Aeromonadales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_939945_1 929558.SMGD1_2653 4.41e-07 50.4 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2YMR0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_939945_2 929558.SMGD1_2652 3.81e-156 457.0 COG2025@1|root,COG2086@1|root,COG2025@2|Bacteria,COG2086@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2YQDA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Electron transfer flavoprotein FAD-binding domain - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_221240_1 298655.KI912267_gene7978 3e-62 196.0 COG0386@1|root,COG0386@2|Bacteria,2IFJH@201174|Actinobacteria,4EV6B@85013|Frankiales 201174|Actinobacteria O Belongs to the glutathione peroxidase family btuE - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_613559_1 1232437.KL661990_gene398 2.31e-50 172.0 COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,42RZJ@68525|delta/epsilon subdivisions,2X6U6@28221|Deltaproteobacteria,2MNDJ@213118|Desulfobacterales 28221|Deltaproteobacteria O UreD urease accessory protein ureD - - ko:K03190 - - - - ko00000 - - - UreD k59_1005418_1 1380387.JADM01000002_gene2230 4.35e-59 191.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1XH5S@135619|Oceanospirillales 135619|Oceanospirillales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_742161_1 1172190.M947_02045 8.94e-28 104.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,42TET@68525|delta/epsilon subdivisions,2YPK6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_742161_2 387092.NIS_1830 3.95e-40 135.0 COG2033@1|root,COG2033@2|Bacteria,1NNT5@1224|Proteobacteria,42TKZ@68525|delta/epsilon subdivisions,2YPSG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_448738_1 1347342.BN863_6250 1.86e-76 258.0 COG3292@1|root,COG3920@1|root,COG3292@2|Bacteria,COG3920@2|Bacteria,4NK8Q@976|Bacteroidetes,1IMWE@117743|Flavobacteriia 976|Bacteroidetes T Two component regulator propeller - - - - - - - - - - - - GAF_2,GerE,HATPase_c,HTH_18,Reg_prop,SpoIIE,Y_Y_Y k59_776110_1 1137281.D778_00506 1.46e-33 129.0 COG3287@1|root,COG3287@2|Bacteria,4NGTB@976|Bacteroidetes,1HX3X@117743|Flavobacteriia 976|Bacteroidetes T FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_906861_1 1380394.JADL01000001_gene2282 2.27e-148 435.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,2JQ7K@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_873678_1 1168034.FH5T_16575 9.87e-130 379.0 COG1373@1|root,COG1373@2|Bacteria,4NE3E@976|Bacteroidetes,2FQ28@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - ko:K07133 - - - - ko00000 - - - AAA_14 k59_122750_1 96561.Dole_0550 1.67e-132 392.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_89948_1 309799.DICTH_0721 4.66e-81 267.0 COG2804@1|root,COG2804@2|Bacteria 2|Bacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_89948_3 749222.Nitsa_0044 4.21e-13 71.2 2BSET@1|root,32MGT@2|Bacteria,1Q39R@1224|Proteobacteria,42WZN@68525|delta/epsilon subdivisions,2YQU4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl k59_679305_1 761193.Runsl_1466 1.01e-05 55.8 COG2373@1|root,COG2373@2|Bacteria,4NEW9@976|Bacteroidetes,47MDC@768503|Cytophagia 976|Bacteroidetes S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,A2M_comp,MG1,Thiol-ester_cl k59_580294_1 572480.Arnit_0075 3.52e-33 130.0 COG0694@1|root,COG0790@1|root,COG0694@2|Bacteria,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity nifU - - ko:K07126,ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N,Sel1 k59_580294_2 1123326.JFBL01000001_gene1331 1.94e-38 130.0 2E63D@1|root,32SZ8@2|Bacteria,1N3BN@1224|Proteobacteria,42WAA@68525|delta/epsilon subdivisions,2YQCN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO cowN - - ko:K21694 - - - - ko00000 - - - - k59_516583_1 929558.SMGD1_0062 1.24e-09 58.2 COG3474@1|root,COG3474@2|Bacteria,1QZ1T@1224|Proteobacteria,43CE2@68525|delta/epsilon subdivisions,2YTBN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C k59_516583_2 1537917.JU82_07960 1.75e-72 231.0 COG5002@1|root,COG5002@2|Bacteria,1QUJ9@1224|Proteobacteria,42MEB@68525|delta/epsilon subdivisions,2YMXI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1005439_1 927658.AJUM01000022_gene1104 2.01e-100 310.0 COG2730@1|root,COG2730@2|Bacteria,4NEU5@976|Bacteroidetes,2FNKD@200643|Bacteroidia,3XINH@558415|Marinilabiliaceae 976|Bacteroidetes G Cellulase (glycosyl hydrolase family 5) celA GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0033946,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0052736,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - BACON,Cellulase,RicinB_lectin_2 k59_227700_1 765911.Thivi_0273 8.8e-77 252.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales 135613|Chromatiales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_259239_2 1168034.FH5T_05370 1.15e-29 118.0 COG4773@1|root,COG4773@2|Bacteria,4PM17@976|Bacteroidetes,2G187@200643|Bacteroidia 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_421902_1 572544.Ilyop_0573 2.11e-33 128.0 COG0608@1|root,COG0608@2|Bacteria,378YU@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score - - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_421902_2 1319815.HMPREF0202_00580 1.55e-49 171.0 COG0544@1|root,COG0544@2|Bacteria,3783R@32066|Fusobacteria 32066|Fusobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_716966_1 867903.ThesuDRAFT_01803 9.88e-28 115.0 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1UIY4@1239|Firmicutes,25EZX@186801|Clostridia 186801|Clostridia T TIGRFAM diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - GAF_2,GGDEF k59_716966_2 40571.JOEA01000003_gene3591 3.52e-67 210.0 COG3647@1|root,COG3647@2|Bacteria,2IATE@201174|Actinobacteria,4E3YF@85010|Pseudonocardiales 201174|Actinobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_879784_1 1168034.FH5T_00055 2.93e-51 179.0 COG0567@1|root,COG0567@2|Bacteria,4NEU9@976|Bacteroidetes,2FMXI@200643|Bacteroidia 976|Bacteroidetes C 2-oxoglutarate dehydrogenase C-terminal sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_227709_2 1168289.AJKI01000029_gene1439 7.74e-24 98.6 COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,2FNSY@200643|Bacteroidia,3XIXB@558415|Marinilabiliaceae 976|Bacteroidetes S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - DUF58 k59_129020_1 1168034.FH5T_12280 1.36e-167 480.0 COG0312@1|root,COG0312@2|Bacteria,4NG2Y@976|Bacteroidetes,2FN09@200643|Bacteroidia 976|Bacteroidetes S Tat pathway signal sequence domain protein tldD1 - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_716973_2 177439.DP0462 7.03e-18 83.6 COG2199@1|root,COG3706@2|Bacteria,1N9PI@1224|Proteobacteria,42MQF@68525|delta/epsilon subdivisions,2WIUE@28221|Deltaproteobacteria,2MJ68@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k59_847206_1 1158604.I591_02841 2.57e-19 82.0 COG0503@1|root,COG0503@2|Bacteria 2|Bacteria F purine ribonucleoside salvage apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - PRTase_2,Pribosyltran,TRSP k59_847206_2 1232666.JANE01000031_gene1378 1.99e-81 247.0 2DB8K@1|root,2Z7S1@2|Bacteria,1TRA1@1239|Firmicutes,4HBIE@91061|Bacilli,4GYUZ@90964|Staphylococcaceae 91061|Bacilli G Streptomycin adenylyltransferase aadK - - ko:K05593 - - - - ko00000,ko01000,ko01504 - - - Adenyl_transf k59_555202_1 579137.Metvu_1679 2e-78 245.0 COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,23QA4@183939|Methanococci 183939|Methanococci E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_227719_1 1168034.FH5T_20770 3.56e-55 182.0 COG0730@1|root,COG0730@2|Bacteria,4NFWP@976|Bacteroidetes,2FVIS@200643|Bacteroidia 976|Bacteroidetes S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_456332_1 1403313.AXBR01000009_gene940 3.2e-78 247.0 COG2962@1|root,COG2962@2|Bacteria,1TQF2@1239|Firmicutes,4HAYU@91061|Bacilli,1ZD78@1386|Bacillus 91061|Bacilli S -transporter rarD - - ko:K05786 - - - - ko00000,ko02000 2.A.7.7 - - EamA k59_456332_2 1196324.A374_04369 5.48e-21 94.0 COG2962@1|root,COG2962@2|Bacteria,1TQF2@1239|Firmicutes,4HAYU@91061|Bacilli 91061|Bacilli S Transporter rarD - - ko:K05786 - - - - ko00000,ko02000 2.A.7.7 - - EamA k59_358550_1 338966.Ppro_0812 1.47e-28 118.0 COG3883@1|root,COG3883@2|Bacteria,1RCHH@1224|Proteobacteria 1224|Proteobacteria S PFAM NLP P60 protein - - - - - - - - - - - - - k59_847221_2 1380387.JADM01000004_gene2852 3.05e-09 57.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1XHMA@135619|Oceanospirillales 135619|Oceanospirillales K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_259264_1 1168034.FH5T_08685 2.91e-193 546.0 COG0215@1|root,COG0215@2|Bacteria,4NE3Y@976|Bacteroidetes,2FM9D@200643|Bacteroidia 976|Bacteroidetes J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_685735_1 1414720.CBYM010000003_gene418 2.83e-232 651.0 COG0833@1|root,COG0833@2|Bacteria,1UHPU@1239|Firmicutes,25E64@186801|Clostridia,36UUC@31979|Clostridiaceae 186801|Clostridia E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_195514_1 1049564.TevJSym_ad00370 9.7e-86 264.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1J4Y7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2485 M20_dimer,Peptidase_M20 k59_912776_1 768671.ThimaDRAFT_3725 1.15e-30 115.0 COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,1S2JU@1236|Gammaproteobacteria,1WY8T@135613|Chromatiales 135613|Chromatiales L PFAM SOUL heme-binding protein - - - - - - - - - - - - SOUL k59_421926_2 933262.AXAM01000032_gene676 9.51e-11 63.2 COG0515@1|root,COG0515@2|Bacteria,1RI1E@1224|Proteobacteria 1224|Proteobacteria KLT Lipopolysaccharide kinase (Kdo/WaaP) family waaP1 - - - - - - - - - - - Kdo k59_195517_1 1255043.TVNIR_2414 2.7e-98 308.0 COG0709@1|root,COG1252@1|root,COG0709@2|Bacteria,COG1252@2|Bacteria,1MWFG@1224|Proteobacteria,1RQ5Q@1236|Gammaproteobacteria,1X13W@135613|Chromatiales 135613|Chromatiales CE AIR synthase related protein, N-terminal domain - - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C,Pyr_redox_2 k59_487048_1 1122173.AXVL01000010_gene1428 6e-26 110.0 COG1762@1|root,COG3711@1|root,COG1762@2|Bacteria,COG3711@2|Bacteria,3786B@32066|Fusobacteria 32066|Fusobacteria GKT PRD domain protein - - - - - - - - - - - - HTH_11,PRD,PTS_EIIA_2 k59_847234_2 1408436.JHXY01000021_gene243 5.06e-08 59.7 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,25VCN@186806|Eubacteriaceae 186801|Clostridia L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_748076_1 864051.BurJ1DRAFT_0974 3.25e-69 234.0 28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,2VPEJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_95840_1 709032.Sulku_2352 2.27e-81 245.0 COG2952@1|root,COG2952@2|Bacteria,1PBRU@1224|Proteobacteria,42MEP@68525|delta/epsilon subdivisions,2YN8A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K09804 - - - - ko00000 - - - DUF507 k59_391532_1 933262.AXAM01000013_gene1324 2.47e-13 71.2 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_487057_2 194439.CT0744 1.4e-15 72.8 COG1607@1|root,COG1607@2|Bacteria,1FEAZ@1090|Chlorobi 1090|Chlorobi I PFAM thioesterase superfamily protein - - - - - - - - - - - - 4HBT k59_685752_1 1172190.M947_05345 4.68e-05 44.7 COG2956@1|root,COG2956@2|Bacteria,1QUIS@1224|Proteobacteria,42M7G@68525|delta/epsilon subdivisions,2YMKN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_7,TPR_8 k59_685752_2 1249480.B649_00410 8.49e-89 267.0 COG1961@1|root,COG1961@2|Bacteria,1Q5XK@1224|Proteobacteria,42TRW@68525|delta/epsilon subdivisions,2YQ0Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L PFAM Resolvase, N terminal domain - - - - - - - - - - - - HTH_7,Resolvase k59_685754_1 1479237.JMLY01000001_gene152 1.81e-51 168.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,465C4@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG4149 ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_685754_2 1449049.JONW01000011_gene2276 4.24e-19 85.1 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,2KF58@204458|Caulobacterales 204458|Caulobacterales P Molybdenum ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_782565_1 1121918.ARWE01000001_gene3374 1.15e-81 260.0 COG1061@1|root,COG1787@1|root,COG1061@2|Bacteria,COG1787@2|Bacteria,1MV9F@1224|Proteobacteria,42NS1@68525|delta/epsilon subdivisions,2WQXY@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Type III restriction protein res subunit - - - ko:K19789 - - - - ko00000,ko03400 - - - Helicase_C,ResIII,UPF0547 k59_879838_1 292459.STH311 1.42e-30 130.0 28HN3@1|root,2Z7WH@2|Bacteria,1TQ7U@1239|Firmicutes,24BMY@186801|Clostridia 186801|Clostridia S CRISPR-associated protein, Csd1 family csd1 - - ko:K19117 - - - - ko00000,ko02048 - - - Cas_Csd1 k59_946500_1 1056820.KB900681_gene2859 4.42e-88 270.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_685766_1 1121405.dsmv_2359 2.04e-68 234.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2MIQM@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_61764_1 2340.JV46_21960 4.81e-85 278.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_95875_1 1499967.BAYZ01000074_gene2123 4.76e-71 228.0 COG0438@1|root,COG0438@2|Bacteria,2NQHY@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1,Glycos_transf_2 k59_421948_1 387093.SUN_0355 9.33e-154 442.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2YN6C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidase U32 family prtC - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_358598_1 1028307.EAE_05840 9.96e-55 184.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,3X1IC@547|Enterobacter 1236|Gammaproteobacteria C alcohol dehydrogenase eutG - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_946513_1 1129794.C427_2841 3.93e-26 103.0 COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Conserved Protein - - - - - - - - - - - - DUF1232 k59_946513_2 1122603.ATVI01000009_gene2504 1.84e-11 64.7 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1X3M1@135614|Xanthomonadales 135614|Xanthomonadales I Fatty acid synthesis protein - - - - - - - - - - - - FA_synthesis k59_421952_1 555779.Dthio_PD3358 5.97e-05 47.0 COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2MBG2@213115|Desulfovibrionales 28221|Deltaproteobacteria T Universal stress protein usp-2 - - ko:K06149 - - - - ko00000 - - - Usp k59_421952_2 439235.Dalk_3262 6.24e-16 73.9 COG0745@1|root,COG0745@2|Bacteria,1RINR@1224|Proteobacteria,42T1R@68525|delta/epsilon subdivisions,2WPHY@28221|Deltaproteobacteria,2MK8T@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_652063_1 179408.Osc7112_5903 5.61e-12 72.0 COG0517@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4251@1|root,COG0517@2|Bacteria,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4251@2|Bacteria,1GHFQ@1117|Cyanobacteria,1HHWS@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA,PAS_9,Response_reg k59_1011485_2 765912.Thimo_2449 1.34e-41 144.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1WWJ2@135613|Chromatiales 135613|Chromatiales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_912829_1 522306.CAP2UW1_3234 2.58e-63 201.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,2VKGR@28216|Betaproteobacteria 1224|Proteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_946536_1 1238190.AMQY01000011_gene1945 1.36e-84 283.0 COG0591@1|root,COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1XH3H@135619|Oceanospirillales 135619|Oceanospirillales T COG0591 Na proline symporter - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,SSF k59_129159_1 66869.JNXG01000005_gene2169 1.27e-45 159.0 2AAD4@1|root,30ZP1@2|Bacteria,2HPD2@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_259313_1 1168034.FH5T_01470 2.38e-102 308.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FWYQ@200643|Bacteroidia 976|Bacteroidetes T Sigma-54 interaction domain - - - - - - - - - - - - Response_reg,Sigma54_activat k59_946539_1 1242969.ATCC51562_285 2.18e-07 58.2 COG4968@1|root,COG4968@2|Bacteria,1QUIY@1224|Proteobacteria,42S53@68525|delta/epsilon subdivisions,2YPC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prepilin-type N-terminal cleavage methylation domain - - - - - - - - - - - - N_methyl k59_946541_1 216432.CA2559_05665 2.51e-18 85.1 COG0521@1|root,COG0521@2|Bacteria,4NHV5@976|Bacteroidetes,1HXT5@117743|Flavobacteriia 976|Bacteroidetes H Starch-binding associating with outer membrane - - - - - - - - - - - - SusD-like,SusD-like_2 k59_811875_1 287.DR97_3358 2.64e-50 179.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1YERK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_1043771_1 1121875.KB907547_gene3379 5.62e-40 144.0 COG2311@1|root,COG2311@2|Bacteria,4NG01@976|Bacteroidetes,1HZVC@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF418) - - - ko:K07148 - - - - ko00000 - - - DUF418 k59_1043771_2 1353276.JADR01000014_gene2989 8.05e-21 90.1 2E3AK@1|root,32YA3@2|Bacteria,4NUYM@976|Bacteroidetes,1I52E@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_391628_1 1168034.FH5T_10090 0.0 959.0 COG0458@1|root,COG0458@2|Bacteria,4NEQ0@976|Bacteroidetes,2FMKD@200643|Bacteroidia 976|Bacteroidetes EF Carbamoyl-phosphate synthase (glutamine-hydrolyzing) carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_947408_4 749222.Nitsa_1051 5e-302 849.0 COG1203@1|root,COG1203@2|Bacteria,1MX7A@1224|Proteobacteria,42Q2Q@68525|delta/epsilon subdivisions,2YNRF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L CRISPR-associated helicase, Cas3 cas3 - - ko:K07012 - - - - ko00000,ko01000,ko02048 - - - DEAD,Helicase_C,ResIII k59_947408_5 749222.Nitsa_1050 2.77e-121 351.0 COG1688@1|root,COG1688@2|Bacteria,1NZNR@1224|Proteobacteria,42NSW@68525|delta/epsilon subdivisions,2YMWA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Crispr-associated protein Cas5, hmari subtype cas5 - - ko:K19116 - - - - ko00000,ko02048 - - - Cas_Cas5d k59_947408_6 749222.Nitsa_1049 2.92e-194 542.0 COG3649@1|root,COG3649@2|Bacteria,1MV2A@1224|Proteobacteria,42NMW@68525|delta/epsilon subdivisions,2YNNB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L hmm pf05107 cas7 - - ko:K19115 - - - - ko00000,ko02048 - - - Cas_Cas7 k59_947408_7 749222.Nitsa_1048 3.46e-81 260.0 2AHY5@1|root,318B7@2|Bacteria,1Q03V@1224|Proteobacteria,42PEM@68525|delta/epsilon subdivisions,2YNPX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - cas8 - - ko:K19114 - - - - ko00000,ko02048 - - - Cas_TM1802 k59_620797_1 1408439.JHXW01000004_gene1368 7.76e-48 166.0 COG0471@1|root,COG0471@2|Bacteria 2|Bacteria P metal ion transport - - - - - - - - - - - - MatC_N,Na_sulph_symp k59_620797_2 1408439.JHXW01000004_gene1368 1.18e-42 151.0 COG0471@1|root,COG0471@2|Bacteria 2|Bacteria P metal ion transport - - - - - - - - - - - - MatC_N,Na_sulph_symp k59_1012157_1 987059.RBXJA2T_00560 9.85e-39 135.0 COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VSW6@28216|Betaproteobacteria,1KKTH@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_1044468_1 216142.LT40_14790 2.65e-31 127.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_62361_1 933262.AXAM01000053_gene2710 5.68e-95 286.0 COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,42MH3@68525|delta/epsilon subdivisions,2WJAA@28221|Deltaproteobacteria,2MIWU@213118|Desulfobacterales 28221|Deltaproteobacteria E LAO AO transport system - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_359418_1 1565314.OA34_03025 1.31e-54 187.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2YN93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH anthranilate synthase component trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP1282 Anth_synt_I_N,Chorismate_bind k59_913711_1 316055.RPE_1360 8.99e-43 152.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2TQS4@28211|Alphaproteobacteria,3JUJ9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K LysR substrate binding domain - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_588000_1 525897.Dbac_0945 7.28e-54 188.0 COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,42NDR@68525|delta/epsilon subdivisions,2WJQ4@28221|Deltaproteobacteria,2M9X7@213115|Desulfovibrionales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit - - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_228586_1 1229172.JQFA01000002_gene2578 2.05e-74 236.0 COG0624@1|root,COG0624@2|Bacteria,1G3WM@1117|Cyanobacteria 1117|Cyanobacteria E peptidase dimerisation domain - - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_130027_1 1298593.TOL_3236 7.59e-17 79.7 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1XH38@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_130027_2 557598.LHK_02958 7.5e-65 203.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,2KR45@206351|Neisseriales 206351|Neisseriales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_422959_1 582402.Hbal_1633 1.07e-29 117.0 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2TUER@28211|Alphaproteobacteria,43Y9F@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_297794_5 484770.UFO1_3750 1.26e-244 685.0 COG2160@1|root,COG2160@2|Bacteria,1TPXC@1239|Firmicutes,4H3WT@909932|Negativicutes 909932|Negativicutes G Catalyzes the conversion of L-arabinose to L-ribulose araA - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Iso_C,Arabinose_Isome k59_297794_6 526218.Sterm_0125 4.98e-126 363.0 COG0235@1|root,COG0235@2|Bacteria,378Q7@32066|Fusobacteria 32066|Fusobacteria G L-ribulose-5-phosphate 4-epimerase araD - 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_297794_7 748449.Halha_1320 2.26e-132 388.0 COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,249DZ@186801|Clostridia,3WBD8@53433|Halanaerobiales 186801|Clostridia G Converts alpha-aldose to the beta-anomer - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_297794_8 1094508.Tsac_0327 4.65e-104 306.0 COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,42EPM@68295|Thermoanaerobacterales 186801|Clostridia F Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_297794_9 572544.Ilyop_1484 3.11e-156 443.0 COG3959@1|root,COG3959@2|Bacteria,378CZ@32066|Fusobacteria 32066|Fusobacteria G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_265013_1 927658.AJUM01000042_gene1739 4.1e-75 249.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - - ko:K06889,ko:K07214 - - - - ko00000 - - - Esterase,Peptidase_S9 k59_265014_1 1249480.B649_09680 2.69e-103 308.0 COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions,2YNGT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Hydrogenase-4, component G - - - ko:K14090 - - - - ko00000 - - - Complex1_49kDa,NiFeSe_Hases k59_919585_1 1165841.SULAR_06588 3.62e-121 360.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YMGI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_297800_2 1121918.ARWE01000001_gene3573 1.85e-45 157.0 COG3221@1|root,COG3221@2|Bacteria 2|Bacteria P organic phosphonate transport - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_591807_1 1159488.SEQMU2_04865 4.58e-76 251.0 COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,4HB5N@91061|Bacilli,4GY50@90964|Staphylococcaceae 91061|Bacilli C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate citB GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0050789,GO:0050793,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0065007,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS06730 Aconitase,Aconitase_C k59_591807_2 572544.Ilyop_0225 9.61e-158 450.0 COG0473@1|root,COG0473@2|Bacteria,379J2@32066|Fusobacteria 32066|Fusobacteria CE Psort location Cytoplasmic, score 9.97 - - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_722967_1 1443125.Z962_04480 5.69e-74 234.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,36EAX@31979|Clostridiaceae 186801|Clostridia C alcohol dehydrogenase gbsB - - - - - - - - - - - Fe-ADH k59_788317_1 1049564.TevJSym_bd00040 5.99e-95 289.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1J515@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Flavocytochrome c sulphide dehydrogenase, flavin-binding fccB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_591812_1 1168034.FH5T_18040 3.39e-137 400.0 COG3303@1|root,COG3303@2|Bacteria,4NG0P@976|Bacteroidetes,2FP37@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process nrfA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 k59_232784_1 610130.Closa_3181 1.87e-94 294.0 COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,21XWM@1506553|Lachnoclostridium 186801|Clostridia J COG COG0480 Translation elongation factors (GTPases) tetM - - ko:K18220 - - - - br01600,ko00000,ko01504 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_951893_1 439235.Dalk_2427 1.82e-15 79.7 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain adiA - 2.7.7.65,4.1.1.19 ko:K01584,ko:K20955 ko00330,ko01100,ko05111,map00330,map01100,map05111 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - GAF,GGDEF,HATPase_c,HisKA,NB-ARC,OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N,Response_reg,TPR_12,dCache_1 k59_1017166_1 1168034.FH5T_08815 5.26e-114 360.0 COG1729@1|root,COG1729@2|Bacteria,4PKGA@976|Bacteroidetes,2G3G6@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 k59_755360_1 1168034.FH5T_00570 3.1e-33 128.0 COG2382@1|root,COG2382@2|Bacteria,4NFVV@976|Bacteroidetes,2FNXZ@200643|Bacteroidia 976|Bacteroidetes P Enterochelin esterase - - - ko:K07214 - - - - ko00000 - - - CBM_48,Esterase k59_69147_1 265072.Mfla_0635 2.72e-94 307.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KM5C@206350|Nitrosomonadales 206350|Nitrosomonadales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_1017180_2 1219626.HMPREF1639_02545 1.28e-41 148.0 COG0246@1|root,COG0246@2|Bacteria,1TPZU@1239|Firmicutes,248J5@186801|Clostridia,25QQI@186804|Peptostreptococcaceae 186801|Clostridia C Mannitol dehydrogenase Rossmann domain mtlD - 1.1.1.17 ko:K00009 ko00051,map00051 - R02703 RC00085 ko00000,ko00001,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_135012_1 1117314.PCIT_13179 7.58e-08 55.1 COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,1RNM4@1236|Gammaproteobacteria,2Q3ID@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_135012_2 702113.PP1Y_AT20270 3.91e-05 52.4 COG2267@1|root,COG2267@2|Bacteria,1QWE3@1224|Proteobacteria,2UDWQ@28211|Alphaproteobacteria,2K630@204457|Sphingomonadales 204457|Sphingomonadales I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_199849_1 1168034.FH5T_08600 2.52e-43 150.0 2AH37@1|root,317CH@2|Bacteria,4P87Y@976|Bacteroidetes 1168034.FH5T_08600|- - - - - - - - - - - - - - - - k59_591840_1 879212.DespoDRAFT_01512 7.75e-122 353.0 COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WJX8@28221|Deltaproteobacteria,2MJAF@213118|Desulfobacterales 28221|Deltaproteobacteria C NADH ubiquinone oxidoreductase, 20 Kd subunit ehrS - - - - - - - - - - iAF987.Gmet_2596 Fer4,Fer4_7,Oxidored_q6 k59_363471_1 247634.GPB2148_1747 6.2e-92 283.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1J530@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria FP Belongs to the GppA Ppx family gppA GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006797,GO:0006798,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008894,GO:0009056,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0042594,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:1901360,GO:1901575 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463,iECIAI39_1322.ECIAI39_2643 HD,Ppx-GppA k59_919629_1 1249627.D779_3155 6.52e-91 278.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RRGA@1236|Gammaproteobacteria,1WX0C@135613|Chromatiales 135613|Chromatiales E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_168388_1 1121405.dsmv_3219 2.99e-79 248.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2WJB8@28221|Deltaproteobacteria,2MHR6@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_2992_2 439235.Dalk_0106 1.1e-31 123.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42YAX@68525|delta/epsilon subdivisions,2WU3C@28221|Deltaproteobacteria,2MMI7@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_265479_2 526218.Sterm_4011 5.29e-102 308.0 COG1879@1|root,COG1879@2|Bacteria,3793S@32066|Fusobacteria 2|Bacteria G Periplasmic binding protein domain - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_36644_1 1121935.AQXX01000119_gene4803 1.47e-148 439.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1XMXM@135619|Oceanospirillales 135619|Oceanospirillales J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_592357_1 1408439.JHXW01000003_gene1659 2.89e-83 258.0 COG0172@1|root,COG0172@2|Bacteria,378ZK@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_723437_1 945543.VIBR0546_07232 0.000155 50.1 COG3468@1|root,COG3468@2|Bacteria,1QUC4@1224|Proteobacteria,1T1SM@1236|Gammaproteobacteria,1Y3BD@135623|Vibrionales 135623|Vibrionales MU Chitinase class I - - - - - - - - - - - - Glyco_hydro_19 k59_364003_1 765912.Thimo_3030 1.94e-45 159.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_658648_1 744872.Spica_1647 9.05e-58 180.0 COG0347@1|root,COG0347@2|Bacteria,2J7M4@203691|Spirochaetes 203691|Spirochaetes K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II k59_658648_2 1407650.BAUB01000003_gene746 6.2e-10 60.5 COG0004@1|root,COG0004@2|Bacteria,1G0S8@1117|Cyanobacteria,1GYV7@1129|Synechococcus 1117|Cyanobacteria P Ammonium Transporter amt1 - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_298279_1 1379698.RBG1_1C00001G0297 6.32e-112 335.0 COG4881@1|root,COG4881@2|Bacteria 2|Bacteria - - cbcU - - - - - - - - - - - NrfD k59_298279_2 1379698.RBG1_1C00001G0296 1.44e-77 236.0 COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 k59_168404_1 153948.NAL212_0823 1.94e-56 178.0 COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2VSWS@28216|Betaproteobacteria,373DM@32003|Nitrosomonadales 28216|Betaproteobacteria S Putative member of DMT superfamily (DUF486) - - - ko:K09922 - - - - ko00000 - - - DMT_6 k59_755811_1 1249480.B649_10560 4.12e-40 171.0 COG1195@1|root,COG1361@1|root,COG3055@1|root,COG1195@2|Bacteria,COG1361@2|Bacteria,COG3055@2|Bacteria 2|Bacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - ko:K12287 - - - - ko00000,ko02044 - - - Calx-beta,Kelch_1,Laminin_G_3 k59_102848_1 394221.Mmar10_1474 1.52e-43 155.0 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,2VFH0@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_69665_1 1123371.ATXH01000018_gene1389 1.86e-67 209.0 COG1586@1|root,COG1586@2|Bacteria,2GGST@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine - - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_788848_1 1168034.FH5T_16975 3.23e-98 295.0 2DRZU@1|root,33DVD@2|Bacteria,4P3PD@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_854324_1 709032.Sulku_1796 1.55e-27 105.0 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2YPC4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_854324_2 572544.Ilyop_1674 5.71e-183 520.0 COG0484@1|root,COG0484@2|Bacteria,378NF@32066|Fusobacteria 32066|Fusobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_854324_3 572544.Ilyop_1673 3.28e-34 120.0 COG1862@1|root,COG1862@2|Bacteria,37AKX@32066|Fusobacteria 32066|Fusobacteria U Preprotein translocase subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_854324_4 596323.HMPREF0554_1242 5.35e-60 203.0 COG0860@1|root,COG0860@2|Bacteria,37886@32066|Fusobacteria 32066|Fusobacteria M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_854324_6 484770.UFO1_3164 0.0 1054.0 COG3962@1|root,COG3962@2|Bacteria,1UI18@1239|Firmicutes,4H37B@909932|Negativicutes 909932|Negativicutes E Belongs to the TPP enzyme family - - 3.7.1.22 ko:K03336 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08603 RC02331 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_854324_7 622312.ROSEINA2194_03002 2.84e-35 132.0 COG2017@1|root,COG2017@2|Bacteria,1U26T@1239|Firmicutes,24AQ8@186801|Clostridia 186801|Clostridia G Aldose 1-epimerase lacX - - - - - - - - - - - Aldose_epim k59_886452_2 709032.Sulku_0589 4.98e-137 394.0 28PS1@1|root,2ZCDP@2|Bacteria,1NFKK@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_886452_3 709032.Sulku_0588 1.6e-51 176.0 COG1794@1|root,COG1794@2|Bacteria 2|Bacteria M racemase activity, acting on amino acids and derivatives mcyF - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_494988_1 40215.BBOS01000025_gene1158 2.54e-62 211.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3NIPR@468|Moraxellaceae 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadB GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200 3HCDH,3HCDH_N,ECH_1 k59_494988_2 207954.MED92_08296 1.71e-21 92.4 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1XHJA@135619|Oceanospirillales 135619|Oceanospirillales I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_364018_1 765911.Thivi_4352 6.42e-63 205.0 COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,1RPGR@1236|Gammaproteobacteria,1WWYY@135613|Chromatiales 135613|Chromatiales S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_233334_1 768710.DesyoDRAFT_3331 9.78e-33 124.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,261TN@186807|Peptococcaceae 186801|Clostridia I PFAM 3-hydroxyacyl-CoA dehydrogenase hbd2 - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_233334_2 944547.ABLL_0117 1.52e-15 76.3 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2YMES@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_788852_1 933262.AXAM01000003_gene2796 1.8e-55 180.0 COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,2MHT7@213118|Desulfobacterales 28221|Deltaproteobacteria O Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_788852_2 177437.HRM2_10870 4.46e-16 79.3 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MIIU@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_527824_1 1137799.GZ78_04225 1.7e-22 91.7 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1XJQQ@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_527824_2 1384054.N790_14300 1.72e-101 318.0 COG4772@1|root,COG4772@2|Bacteria,1MWDG@1224|Proteobacteria,1RQA5@1236|Gammaproteobacteria,1X5QP@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K16091 - - - - ko00000,ko02000 1.B.14.1.14 - - Plug,TonB_dep_Rec k59_331659_1 1340493.JNIF01000003_gene2069 6.93e-26 101.0 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_19,HTH_3,HTH_31 k59_135631_1 1123257.AUFV01000002_gene2345 1.59e-15 77.8 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria,1X50M@135614|Xanthomonadales 135614|Xanthomonadales OU Peptidase family S49 N-terminal - - - - - - - - - - - - Peptidase_S49,Peptidase_S49_N k59_265509_1 378806.STAUR_3535 3.74e-47 159.0 COG1177@1|root,COG1177@2|Bacteria,1N3TB@1224|Proteobacteria,42Z0E@68525|delta/epsilon subdivisions,2WTTD@28221|Deltaproteobacteria,2Z33I@29|Myxococcales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_265509_2 1265490.JHVY01000005_gene1406 1.83e-08 55.5 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family prr GO:0003674,GO:0003824,GO:0004029,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019145,GO:0033737,GO:0034641,GO:0042402,GO:0042802,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575 1.2.1.19 ko:K00137 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R02549 RC00080 ko00000,ko00001,ko01000 - - iAF1260.b1444,iBWG_1329.BWG_1269,iECDH10B_1368.ECDH10B_1574,iECDH1ME8569_1439.ECDH1ME8569_1387,iEcDH1_1363.EcDH1_2202,iJO1366.b1444,iY75_1357.Y75_RS07595 Aldedh k59_1017713_1 396588.Tgr7_1390 1.47e-67 219.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,1WWBX@135613|Chromatiales 135613|Chromatiales S PFAM Flavin containing amine oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase k59_821692_1 1121335.Clst_1174 3.15e-22 92.0 COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,3WJ7X@541000|Ruminococcaceae 186801|Clostridia H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_821692_2 572544.Ilyop_1082 3.48e-51 167.0 COG1762@1|root,COG1762@2|Bacteria,37ADX@32066|Fusobacteria 32066|Fusobacteria H Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_592388_1 1249627.D779_3324 1.15e-34 125.0 COG0589@1|root,COG0589@2|Bacteria,1NB6E@1224|Proteobacteria,1SEN6@1236|Gammaproteobacteria,1WZ7A@135613|Chromatiales 135613|Chromatiales T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_592388_2 2340.JV46_20200 1.52e-24 101.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1017714_1 1168034.FH5T_20530 5.41e-113 334.0 COG3426@1|root,COG3426@2|Bacteria,4NJBW@976|Bacteroidetes,2FMMN@200643|Bacteroidia 976|Bacteroidetes H Belongs to the acetokinase family buk - 2.7.2.7 ko:K00929 ko00650,ko01100,map00650,map01100 - R01688 RC00002,RC00043 ko00000,ko00001,ko01000 - - - Acetate_kinase k59_658671_1 395493.BegalDRAFT_1065 1.28e-119 358.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,463UV@72273|Thiotrichales 72273|Thiotrichales C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.5.1 ko:K05922 - - - - ko00000,ko01000 - - - NiFeSe_Hases k59_102852_2 572544.Ilyop_0585 8.16e-192 539.0 COG1077@1|root,COG1077@2|Bacteria,378FF@32066|Fusobacteria 32066|Fusobacteria D cell shape determining protein, MreB Mrl mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_102852_3 572544.Ilyop_0584 2.54e-75 231.0 COG0424@1|root,COG0424@2|Bacteria,37A0M@32066|Fusobacteria 32066|Fusobacteria D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_298305_1 1168034.FH5T_17590 2.04e-99 307.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,4NFZR@976|Bacteroidetes,2G2QE@200643|Bacteroidia 976|Bacteroidetes O Psort location Extracellular, score - - - - - - - - - - - - PD40,PDZ_2,Peptidase_M28 k59_3016_1 713586.KB900536_gene1698 1.56e-40 138.0 COG4769@1|root,COG4769@2|Bacteria,1RJIB@1224|Proteobacteria,1SBYC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Heptaprenyl diphosphate synthase component I - - 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 - R09247 RC00279 ko00000,ko00001,ko01000,ko01006 - - - Hpre_diP_synt_I k59_723474_1 1112217.PPL19_19757 4.11e-22 100.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria 1236|Gammaproteobacteria K esterase of the alpha-beta hydrolase superfamily plpD - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_658681_1 768671.ThimaDRAFT_2746 5.16e-103 317.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_495008_1 436717.AOLE_13215 3.94e-18 82.8 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,1RRB6@1236|Gammaproteobacteria,3NTAC@468|Moraxellaceae 1236|Gammaproteobacteria S Predicted Peptidoglycan domain - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_495008_2 40215.BBOS01000013_gene3029 4.11e-07 50.8 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,1RRB6@1236|Gammaproteobacteria,3NTAC@468|Moraxellaceae 1236|Gammaproteobacteria S Predicted Peptidoglycan domain - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_200388_1 1168034.FH5T_06765 4.38e-120 347.0 COG0528@1|root,COG0528@2|Bacteria,4NE8Z@976|Bacteroidetes,2FMES@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_432978_11 765911.Thivi_1037 1.26e-104 317.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_432978_13 2340.JV46_20460 2.42e-52 169.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1J67T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_432978_14 1049564.TevJSym_ad00700 7.3e-86 255.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1J5Y6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0380 DMRL_synthase k59_432978_15 1049564.TevJSym_ad00690 9.4e-186 525.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1J4CF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0516,iJN746.PP_3813 DHBP_synthase,GTP_cyclohydro2 k59_432978_16 765911.Thivi_1033 3.83e-101 299.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1WXA6@135613|Chromatiales 135613|Chromatiales H riboflavin synthase, alpha subunit - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_432978_17 631362.Thi970DRAFT_04937 4.71e-147 428.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales 135613|Chromatiales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_432978_18 1249627.D779_1802 3.63e-84 252.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1WX91@135613|Chromatiales 135613|Chromatiales K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_432978_19 1049564.TevJSym_ab01480 1.52e-268 739.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1J4EX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_336610_1 1304885.AUEY01000050_gene1198 1.82e-126 373.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WJVC@28221|Deltaproteobacteria,2MINJ@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_1022125_1 1158165.KB898874_gene1901 9.46e-05 44.7 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_1022125_2 1384054.N790_07395 7.05e-36 127.0 COG1695@1|root,COG1695@2|Bacteria,1NJSY@1224|Proteobacteria,1SG6R@1236|Gammaproteobacteria,1X6UG@135614|Xanthomonadales 135614|Xanthomonadales K PadR family transcriptional regulator - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR k59_1022125_3 666685.R2APBS1_1312 2.43e-05 45.8 COG4709@1|root,COG4709@2|Bacteria,1NX5K@1224|Proteobacteria,1SPS6@1236|Gammaproteobacteria,1X34I@135614|Xanthomonadales 135614|Xanthomonadales S Putative sensor - - - - - - - - - - - - Sensor k59_368805_2 387093.SUN_1642 1.57e-57 185.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2YP5U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C hydrogenase maturation protease hydD - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_368805_3 69014.TK0002 2.13e-09 57.0 COG1451@1|root,arCOG02625@2157|Archaea,2Y0AZ@28890|Euryarchaeota,243SV@183968|Thermococci 183968|Thermococci S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_695127_1 547559.Nmag_2690 2.44e-18 85.1 COG3247@1|root,arCOG10041@2157|Archaea,2XWIC@28890|Euryarchaeota,23V5B@183963|Halobacteria 183963|Halobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_466845_1 1223410.KN050846_gene498 2.52e-154 441.0 COG0183@1|root,COG0183@2|Bacteria,4NE3Q@976|Bacteroidetes,1HX7B@117743|Flavobacteriia 976|Bacteroidetes I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation phbA - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_890951_1 207559.Dde_0648 9.18e-41 148.0 COG0247@1|root,COG0247@2|Bacteria,1R467@1224|Proteobacteria,42NIQ@68525|delta/epsilon subdivisions,2WIUU@28221|Deltaproteobacteria,2MGJ7@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain hmcF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - - - - - - - - - - CCG,Fer4_17 k59_989634_1 1449049.JONW01000006_gene3277 8.6e-15 70.9 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2UDEK@28211|Alphaproteobacteria,2KGZA@204458|Caulobacterales 204458|Caulobacterales S PFAM Membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_989634_2 1442599.JAAN01000030_gene2146 3.01e-158 465.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales 135614|Xanthomonadales S transporter oliA - - - - - - - - - - - OPT k59_336618_1 314345.SPV1_12415 2.86e-69 225.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria 1224|Proteobacteria M mechanosensitive ion channel aefA - - - - - - - - - - - MS_channel k59_400729_1 272942.RCAP_rcc00774 4.94e-45 156.0 COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,2U0HG@28211|Alphaproteobacteria,1FAWR@1060|Rhodobacter 28211|Alphaproteobacteria C Pfam:DUF3457 hupJ - - - - - - - - - - - NiFe-hyd_HybE,Rubredoxin k59_858227_1 387093.SUN_2279 1.37e-58 183.0 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,42SBM@68525|delta/epsilon subdivisions,2YPGH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_858227_2 387093.SUN_2278 3.65e-29 107.0 COG0718@1|root,COG0718@2|Bacteria,1Q3T8@1224|Proteobacteria,42UGW@68525|delta/epsilon subdivisions,2YPUE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_826002_1 187272.Mlg_1812 5.75e-53 174.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1WX0F@135613|Chromatiales 135613|Chromatiales S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_40303_1 1408473.JHXO01000009_gene3424 1.35e-110 327.0 COG1748@1|root,COG1748@2|Bacteria,4NE0Y@976|Bacteroidetes,2FMKT@200643|Bacteroidia 976|Bacteroidetes E Saccharopine dehydrogenase LYS1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_924720_1 1249627.D779_3945 1.95e-86 278.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1WWCN@135613|Chromatiales 135613|Chromatiales S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - - - - - - - - - - Peptidase_M48,TPR_19 k59_956230_1 243233.MCA0345 1.82e-84 259.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XE3A@135618|Methylococcales 135618|Methylococcales C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_336631_1 1464048.JNZS01000047_gene687 2.71e-40 151.0 COG1960@1|root,COG1960@2|Bacteria,2GKK9@201174|Actinobacteria,4DB5R@85008|Micromonosporales 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain fadE10 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_532587_1 631362.Thi970DRAFT_03858 1.03e-86 273.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_759856_1 1345697.M493_09345 8.15e-58 184.0 COG0684@1|root,COG0684@2|Bacteria,1V3H1@1239|Firmicutes,4HH1C@91061|Bacilli,1WE4U@129337|Geobacillus 91061|Bacilli H Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions rraA - - ko:K02553 - - - - ko00000,ko03019 - - - RraA-like k59_759856_2 713587.THITH_01520 5.35e-45 147.0 COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1WYU9@135613|Chromatiales 135613|Chromatiales CO Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic k59_924729_2 1453505.JASY01000001_gene3615 8.91e-05 45.8 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia,2NVHB@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_368831_1 1265505.ATUG01000001_gene3565 1.77e-121 367.0 COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MHKH@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit - - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Prismane k59_499820_2 656519.Halsa_0894 1.58e-28 110.0 COG3090@1|root,COG3090@2|Bacteria,1VFA6@1239|Firmicutes,24RYE@186801|Clostridia 186801|Clostridia G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_499820_3 1121289.JHVL01000008_gene1275 2.66e-218 613.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,36G8D@31979|Clostridiaceae 186801|Clostridia G Trap dicarboxylate transporter, dctm subunit - - - - - - - - - - - - DctM k59_237623_1 929703.KE386491_gene3079 7.36e-189 575.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,4NEHR@976|Bacteroidetes,47M22@768503|Cytophagia 976|Bacteroidetes L PFAM Eco57I restriction endonuclease - - - - - - - - - - - - Eco57I,N6_Mtase,TaqI_C k59_237623_2 1004149.AFOE01000033_gene666 3.12e-234 702.0 COG0553@1|root,COG3886@1|root,COG0553@2|Bacteria,COG3886@2|Bacteria,4NH3B@976|Bacteroidetes,1HZ1X@117743|Flavobacteriia 976|Bacteroidetes L Helicase - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII,SNF2_N k59_237623_3 1249480.B649_03795 4.17e-202 565.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MWV@68525|delta/epsilon subdivisions,2YMTV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Fic/DOC family N-terminal - - - - - - - - - - - - Fic,Fic_N k59_433020_1 396588.Tgr7_0266 5.38e-55 184.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales 135613|Chromatiales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_433020_2 631362.Thi970DRAFT_00019 5.09e-41 140.0 2E0WU@1|root,32WDV@2|Bacteria,1N1G5@1224|Proteobacteria,1S9KI@1236|Gammaproteobacteria,1X104@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_433020_3 1114970.PSF113_3653 9.21e-08 52.8 COG0625@1|root,COG0625@2|Bacteria,1RD2G@1224|Proteobacteria,1S3TT@1236|Gammaproteobacteria,1YNPP@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_826029_1 1123320.KB889681_gene2570 2.74e-49 177.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria 201174|Actinobacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_3 k59_989671_1 1042377.AFPJ01000032_gene2743 9.97e-52 184.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RS1Q@1236|Gammaproteobacteria,469PS@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_368841_1 713587.THITH_07470 1.7e-21 90.1 COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,1T62V@1236|Gammaproteobacteria,1X277@135613|Chromatiales 135613|Chromatiales O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_368841_2 941449.dsx2_2115 6.53e-68 222.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2WIYI@28221|Deltaproteobacteria,2M8GG@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM Sodium sulphate symporter sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_695167_1 177416.FTT_0726c 2.5e-57 190.0 COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria,1SZRP@1236|Gammaproteobacteria,461I5@72273|Thiotrichales 72273|Thiotrichales C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_5741_2 857087.Metme_0291 1.94e-40 146.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1XE9D@135618|Methylococcales 135618|Methylococcales S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_302272_1 1123392.AQWL01000013_gene2383 5.51e-09 60.5 COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria 28216|Betaproteobacteria M Belongs to the ompA family rmpM - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,SmpA_OmlA k59_663249_1 1033810.HLPCO_000626 3.8e-13 68.6 COG1814@1|root,COG1814@2|Bacteria,2NP4E@2323|unclassified Bacteria 2|Bacteria S VIT family - - - - - - - - - - - - Rubrerythrin,VIT1 k59_663249_2 660470.Theba_2464 2.99e-64 211.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport ybdG GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006950,GO:0006970,GO:0008150,GO:0008381,GO:0009628,GO:0009987,GO:0015267,GO:0016020,GO:0022803,GO:0022836,GO:0022857,GO:0033554,GO:0042802,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071214,GO:0071470,GO:0071944,GO:0104004 - ko:K16053 - - - - ko00000,ko02000 1.A.23.4.5 - - MS_channel k59_172828_1 1168065.DOK_15204 3.7e-43 157.0 COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,1J5C4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_400767_1 981327.F925_02872 2.28e-23 93.2 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,3NN44@468|Moraxellaceae 1236|Gammaproteobacteria KT Response regulator receiver domain pilG - - ko:K02657,ko:K03413 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_400767_2 519989.ECTPHS_03879 3.91e-87 266.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales 135613|Chromatiales HJ Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_759881_1 1341157.RF007C_13440 0.000418 50.1 COG0642@1|root,COG2205@2|Bacteria,1VA16@1239|Firmicutes,24NA5@186801|Clostridia,3WP2N@541000|Ruminococcaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_826034_2 526218.Sterm_0853 4.17e-17 90.5 COG1444@1|root,COG1444@2|Bacteria 2|Bacteria J tRNA N-acetyltransferase activity tmcA GO:0000049,GO:0000154,GO:0002097,GO:0002101,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008080,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0022613,GO:0030490,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0051391,GO:0051392,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1904812,GO:1990882,GO:1990883,GO:1990884 2.3.1.193,2.3.1.57 ko:K00657,ko:K06957 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Acetyltransf_1,DUF1726,GNAT_acetyltr_2,Helicase_RecD,tRNA_bind_3 k59_5743_1 886379.AEWI01000208_gene2428 6.26e-28 110.0 COG0454@1|root,COG0456@2|Bacteria,4NNUU@976|Bacteroidetes,2FSZA@200643|Bacteroidia,3XJ5B@558415|Marinilabiliaceae 976|Bacteroidetes K Acetyltransferase (GNAT) family - - 2.3.1.264 ko:K21935 - - R11701 - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_10 k59_826035_1 987059.RBXJA2T_13679 2.45e-35 131.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2VJTA@28216|Betaproteobacteria,1KKEX@119065|unclassified Burkholderiales 28216|Betaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_565000_1 987059.RBXJA2T_10941 7.05e-41 154.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,1KKIR@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Domain of unknown function (DUF3362) - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_532602_1 1537917.JU82_02480 0.0 1703.0 COG0286@1|root,COG0732@1|root,COG0286@2|Bacteria,COG0732@2|Bacteria,1R74K@1224|Proteobacteria,42Q92@68525|delta/epsilon subdivisions,2YN5X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V restriction - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - HSDR_N_2,Methylase_S,N6_Mtase k59_172834_1 1165841.SULAR_07750 5.21e-79 241.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2YMQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_924760_1 161156.JQKW01000012_gene93 6.07e-31 130.0 COG2199@1|root,COG2905@1|root,COG2905@2|Bacteria,COG3706@2|Bacteria,2GHH1@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T diguanylate cyclase - - - - - - - - - - - - CBS,GGDEF,PAS_9 k59_302288_1 714943.Mucpa_5109 1.7e-39 148.0 COG2335@1|root,COG2335@2|Bacteria,4NGU3@976|Bacteroidetes,1IUNS@117747|Sphingobacteriia 976|Bacteroidetes M PFAM Fasciclin domain - - - ko:K19519 - - - - ko00000,ko04516 - - - DUF5108,Fasciclin k59_466901_1 1168034.FH5T_05865 2.24e-122 352.0 COG0745@1|root,COG0745@2|Bacteria,4NG7D@976|Bacteroidetes,2FMJH@200643|Bacteroidia 976|Bacteroidetes T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_565006_1 572544.Ilyop_1449 8.14e-118 346.0 COG0821@1|root,COG0821@2|Bacteria,378T3@32066|Fusobacteria 32066|Fusobacteria H Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_695184_1 1172190.M947_04170 1.26e-224 641.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 k59_858773_1 522306.CAP2UW1_1114 5.37e-36 134.0 COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VRZ3@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_858773_4 28229.ND2E_4216 9.66e-30 119.0 COG3712@1|root,COG3712@2|Bacteria,1QQT3@1224|Proteobacteria,1SKSS@1236|Gammaproteobacteria,2Q7XU@267889|Colwelliaceae 1236|Gammaproteobacteria PT PEP-CTERM motif - - - - - - - - - - - - VPEP k59_858773_5 1230476.C207_06188 3.25e-119 379.0 COG1376@1|root,COG1376@2|Bacteria,1MX14@1224|Proteobacteria,2TS68@28211|Alphaproteobacteria,3JU1F@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_858773_7 156889.Mmc1_1094 9.17e-48 200.0 COG2931@1|root,COG5276@1|root,COG2931@2|Bacteria,COG5276@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_858773_9 1123296.JQKE01000087_gene2179 5.3e-13 73.6 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - Alpha-L-AF_C,An_peroxidase,DUF5011,Laminin_G_3,Peptidase_C80 k59_533242_1 935948.KE386495_gene1816 2.01e-97 303.0 COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,42EQT@68295|Thermoanaerobacterales 186801|Clostridia O PFAM Magnesium chelatase, ChlI subunit comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_369449_1 4081.Solyc01g007610.2.1 3.29e-38 138.0 COG0091@1|root,KOG1711@2759|Eukaryota,3842X@33090|Viridiplantae,3GW7N@35493|Streptophyta,44TSR@71274|asterids 35493|Streptophyta J Ribosomal protein L22p/L17e - GO:0000313,GO:0000315,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0015934,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0031974,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0098798,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_369449_2 72664.XP_006404513.1 1.04e-60 192.0 COG0092@1|root,2QV63@2759|Eukaryota,37ITR@33090|Viridiplantae,3GH7T@35493|Streptophyta,3HXHY@3699|Brassicales 35493|Streptophyta J Belongs to the universal ribosomal protein uS3 family rps3 GO:0002181,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0031967,GO:0031975,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S3_C k59_533244_1 557598.LHK_00320 2.53e-67 221.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KPNZ@206351|Neisseriales 206351|Neisseriales S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_630728_1 161528.ED21_30439 7.19e-17 85.9 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTI2@28211|Alphaproteobacteria,2K0SD@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_891702_1 768671.ThimaDRAFT_2567 2.78e-54 172.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1WYHD@135613|Chromatiales 135613|Chromatiales K regulatory protein, arsR - - - - - - - - - - - - HTH_5 k59_565618_1 1229276.DI53_1070 9.41e-12 65.9 COG3408@1|root,COG3408@2|Bacteria,4NE1I@976|Bacteroidetes,1IRGN@117747|Sphingobacteriia 976|Bacteroidetes G Domain of unknown function (DUF4450) - - - - - - - - - - - - Bac_rhamnosid6H,DUF4450,DUF608 k59_565618_2 1392488.JHZY01000002_gene107 4.05e-197 560.0 COG2755@1|root,COG2755@2|Bacteria,4NG1M@976|Bacteroidetes,1I0P6@117743|Flavobacteriia,2XJT7@283735|Leeuwenhoekiella 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 k59_500494_1 1211114.ALIP01000160_gene1603 4.78e-110 351.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales 135614|Xanthomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_925397_1 1178825.ALIH01000001_gene2392 5.89e-20 88.2 2E5JY@1|root,330B6@2|Bacteria,4NV2G@976|Bacteroidetes,1I56S@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4296) - - - - - - - - - - - - DUF4296 k59_404353_1 1288298.rosmuc_04122 1.45e-24 101.0 2DPDF@1|root,331KJ@2|Bacteria,1P1A4@1224|Proteobacteria,2UR15@28211|Alphaproteobacteria,46P58@74030|Roseovarius 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_404353_2 1432055.GLUCORHAEAF1_13720 5.36e-81 261.0 2DBDI@1|root,2Z8M4@2|Bacteria,1R655@1224|Proteobacteria,2U1J5@28211|Alphaproteobacteria,2JYAY@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_404353_3 1034347.CAHJ01000054_gene172 1.11e-47 169.0 COG3621@1|root,COG3621@2|Bacteria,1UYFU@1239|Firmicutes,4IRZQ@91061|Bacilli,1ZRZH@1386|Bacillus 91061|Bacilli S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_763817_1 29581.BW37_02174 1.89e-10 65.5 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2VPMU@28216|Betaproteobacteria,47698@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_536304_1 468059.AUHA01000002_gene563 1.69e-46 171.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - ANAPC3,Guanylate_cyc,HTH_18,TPR_8 k59_77955_1 709032.Sulku_0223 1.62e-100 297.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,42N84@68525|delta/epsilon subdivisions,2YM7V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0510 DapB_C,DapB_N k59_960110_1 349520.PPE_03011 2.6e-291 897.0 COG2227@1|root,COG3321@1|root,COG4221@1|root,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksR - - ko:K13613,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_895041_1 927658.AJUM01000017_gene3087 1.8e-24 111.0 COG4935@1|root,COG4935@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - CHU_C,FlgD_ig,Inhibitor_I69,PKD,Peptidase_C10,Peptidase_C25,Peptidase_C25_C,Peptidase_M43,Propeptide_C25,SprB k59_993557_1 123899.JPQP01000004_gene524 3.78e-26 107.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,3T1JD@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose ascD - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_372289_1 387092.NIS_0408 2.98e-61 204.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2YMVT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FP Guanosine pentaphosphate phosphohydrolase gppA - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_404359_1 1049564.TevJSym_bl00090 4.94e-96 293.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1J5AS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_861666_2 546274.EIKCOROL_00164 4.3e-14 75.5 COG2932@1|root,COG2932@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3,HTH_Tnp_Mu_1,Peptidase_S24,Phage_CI_repr k59_861666_4 367737.Abu_1690 7.47e-120 380.0 COG2801@1|root,COG2801@2|Bacteria,1MVXV@1224|Proteobacteria,42PU3@68525|delta/epsilon subdivisions,2YQ42@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_28,Mu-transpos_C,rve k59_861666_14 1401065.HMPREF2130_06490 1e-35 131.0 28NH3@1|root,2ZBJ1@2|Bacteria,1R5ME@1224|Proteobacteria,2VQSI@28216|Betaproteobacteria,3T7BX@506|Alcaligenaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3164) - - - - - - - - - - - - DUF3164 k59_861666_16 598659.NAMH_0210 0.000853 47.4 COG0847@1|root,COG0847@2|Bacteria,1PQ1V@1224|Proteobacteria,42PMC@68525|delta/epsilon subdivisions,2YNJA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L dna polymerase iii - - - ko:K10857 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - RNase_T k59_861666_18 367737.Abu_1681 3.7e-81 254.0 COG0305@1|root,341JZ@2|Bacteria,1NY3K@1224|Proteobacteria,42T0S@68525|delta/epsilon subdivisions,2YPPC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L AAA domain - - - - - - - - - - - - AAA_25 k59_861666_23 613026.HRAG_01276 2.25e-61 211.0 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,42P0H@68525|delta/epsilon subdivisions,2YNDE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Phage Mu protein F like protein - - - - - - - - - - - - Phage_Mu_F k59_861666_24 944547.ABLL_1866 1.41e-101 319.0 COG4383@1|root,COG4383@2|Bacteria,1MWNS@1224|Proteobacteria,42U52@68525|delta/epsilon subdivisions,2YTNG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF935) - - - - - - - - - - - - DUF935 k59_861666_25 367737.Abu_1674 4.82e-206 593.0 COG5362@1|root,COG5362@2|Bacteria,1N1KT@1224|Proteobacteria,42N35@68525|delta/epsilon subdivisions,2YN75@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TIGRFAM Phage - - - - - - - - - - - - - k59_861666_26 683083.C414_000080026 4.14e-16 79.0 2A4IX@1|root,30T5G@2|Bacteria,1PCTP@1224|Proteobacteria,42WDW@68525|delta/epsilon subdivisions,2YQMP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF1804) - - - - - - - - - - - - DUF1804 k59_861666_27 367737.Abu_1672 1.15e-32 119.0 2A6QK@1|root,30VIJ@2|Bacteria,1Q4GM@1224|Proteobacteria,4323X@68525|delta/epsilon subdivisions,2YSUN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF1320) - - - - - - - - - - - - DUF1320 k59_861666_30 279714.FuraDRAFT_1722 1.74e-10 68.9 COG4388@1|root,COG4388@2|Bacteria,1RA2J@1224|Proteobacteria,2VMHV@28216|Betaproteobacteria,2KRHG@206351|Neisseriales 206351|Neisseriales S Mu-like prophage I protein - - - - - - - - - - - - Mu-like_Pro k59_861666_34 944547.ABLL_1878 3.42e-38 147.0 COG3948@1|root,COG3948@2|Bacteria,1MUFF@1224|Proteobacteria,42TMH@68525|delta/epsilon subdivisions,2YPXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Baseplate assembly protein J - - - - - - - - - - - - Baseplate_J k59_861666_37 1242969.ATCC51562_1069 7.62e-21 85.5 2AJQX@1|root,31ACU@2|Bacteria,1Q5CK@1224|Proteobacteria,43113@68525|delta/epsilon subdivisions,2YSBQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_861666_40 944547.ABLL_1882 3.65e-111 336.0 COG3497@1|root,COG3497@2|Bacteria,1MW1V@1224|Proteobacteria,42RUK@68525|delta/epsilon subdivisions,2YP8I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S tail sheath protein - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1 k59_177305_2 1049564.TevJSym_ai00950 1.04e-63 197.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1J6BH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Endoribonuclease L-PSP tdcF - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_177305_3 765912.Thimo_0757 1.99e-21 94.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_667653_2 349124.Hhal_2130 3.43e-108 322.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1WW9Z@135613|Chromatiales 135613|Chromatiales S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_667653_3 1500890.JQNL01000001_gene2761 1.3e-09 58.5 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1XBWP@135614|Xanthomonadales 135614|Xanthomonadales T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_470185_1 1168034.FH5T_21890 1.74e-113 343.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,2FN08@200643|Bacteroidia 976|Bacteroidetes C 2-oxoacid acceptor oxidoreductase, alpha subunit porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_667654_1 1172190.M947_07150 2.01e-69 226.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,42QDE@68525|delta/epsilon subdivisions,2YMPN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_437089_1 1287116.X734_17905 1.37e-131 390.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,43GYE@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_764458_2 1286171.EAL2_808p05780 1.26e-10 57.8 COG1143@1|root,COG1143@2|Bacteria,1UMZ8@1239|Firmicutes,25GSU@186801|Clostridia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 k59_569038_1 457415.HMPREF1006_02051 4.15e-56 187.0 COG2230@1|root,COG2230@2|Bacteria,3TC8W@508458|Synergistetes 508458|Synergistetes M Mycolic acid cyclopropane synthetase - - - - - - - - - - - - CMAS k59_209800_1 1040982.AXAL01000020_gene5869 0.000141 48.1 2BDS5@1|root,327FW@2|Bacteria,1N15E@1224|Proteobacteria,2TTQR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM NifQ family protein nifQ - - ko:K15790 - - - - ko00000 - - - NifQ k59_764459_1 1168034.FH5T_01750 7.43e-121 361.0 COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,2FPVW@200643|Bacteroidia 976|Bacteroidetes G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Fucosidase_C k59_177316_1 1168034.FH5T_13835 4.89e-96 286.0 2B0HH@1|root,31SV0@2|Bacteria,4NRU4@976|Bacteroidetes,2FTFR@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_960776_1 159087.Daro_1562 1.69e-42 146.0 COG1668@1|root,COG1668@2|Bacteria,1QWGC@1224|Proteobacteria,2WGYV@28216|Betaproteobacteria,2KZQ1@206389|Rhodocyclales 206389|Rhodocyclales CP ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_960776_2 387093.SUN_2171 6.86e-23 94.7 COG4314@1|root,COG4314@2|Bacteria,1N3G0@1224|Proteobacteria,42U9E@68525|delta/epsilon subdivisions,2YQ2V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C lipoprotein involved in nitrous oxide reduction - - - ko:K19342 - - - - ko00000 - - - NosL k59_994134_1 551789.ATVJ01000001_gene1709 4.78e-77 244.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,43X3X@69657|Hyphomonadaceae 28211|Alphaproteobacteria C COG1271 Cytochrome bd-type quinol oxidase, subunit 1 cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_306366_2 933262.AXAM01000003_gene2818 3.41e-40 139.0 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,42TIF@68525|delta/epsilon subdivisions,2WQC4@28221|Deltaproteobacteria,2MKMF@213118|Desulfobacterales 28221|Deltaproteobacteria I CDP-alcohol phosphatidyltransferase pgsA-2 - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_569049_2 1121447.JONL01000013_gene3685 2.69e-20 89.0 COG5619@1|root,COG5619@2|Bacteria,1RIE1@1224|Proteobacteria,430QN@68525|delta/epsilon subdivisions,2WVMT@28221|Deltaproteobacteria,2MF44@213115|Desulfovibrionales 28221|Deltaproteobacteria S Uncharacterized conserved protein (DUF2290) - - - - - - - - - - - - DUF2290 k59_273072_1 387092.NIS_0315 6.39e-149 430.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2YMR3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_372804_1 1168034.FH5T_06485 3.12e-57 197.0 COG3291@1|root,COG4447@1|root,COG3291@2|Bacteria,COG4447@2|Bacteria,4NGJJ@976|Bacteroidetes,2FRXF@200643|Bacteroidia 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - - k59_144979_1 305700.B447_16006 1.56e-19 81.6 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2VR2N@28216|Betaproteobacteria,2KWBZ@206389|Rhodocyclales 206389|Rhodocyclales J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_144979_2 686340.Metal_3304 1.01e-28 105.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1XFGP@135618|Methylococcales 135618|Methylococcales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_144979_3 83406.HDN1F_03730 1.77e-09 55.5 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_341197_1 526227.Mesil_3504 6.77e-12 62.8 COG4118@1|root,COG4118@2|Bacteria,1WKSW@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus D Antitoxin Phd_YefM, type II toxin-antitoxin system - - - - - - - - - - - - PhdYeFM_antitox k59_341197_2 1206744.BAGL01000004_gene3610 3.38e-21 87.8 COG3744@1|root,COG3744@2|Bacteria,2GSS6@201174|Actinobacteria,4G2EG@85025|Nocardiaceae 201174|Actinobacteria S PIN domain - - - - - - - - - - - - PIN k59_895703_1 243365.CV_2535 4.47e-20 89.0 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,2KQ15@206351|Neisseriales 206351|Neisseriales K Response regulator receiver domain protein narL - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_144982_1 1384056.N787_11830 7.21e-96 303.0 COG4773@1|root,COG4773@2|Bacteria,1MWUQ@1224|Proteobacteria,1SJYF@1236|Gammaproteobacteria,1X5UY@135614|Xanthomonadales 135614|Xanthomonadales P Outer membrane receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_341200_1 572544.Ilyop_1218 3.56e-114 345.0 COG2221@1|root,COG3887@1|root,COG4624@1|root,COG2221@2|Bacteria,COG3887@2|Bacteria,COG4624@2|Bacteria,37BIE@32066|Fusobacteria 32066|Fusobacteria C PFAM hydrogenase large subunit domain protein - - - - - - - - - - - - FeS,Fe_hyd_lg_C,Fer4,PAS k59_764479_1 765912.Thimo_3702 6.02e-51 180.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales 135613|Chromatiales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_111289_1 1442599.JAAN01000005_gene1016 1.11e-123 369.0 COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,1RMNS@1236|Gammaproteobacteria,1X4V2@135614|Xanthomonadales 135614|Xanthomonadales C COG0644 Dehydrogenases (flavoproteins) - - - - - - - - - - - - Trp_halogenase k59_111289_2 913325.N799_06985 3.37e-33 117.0 COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,1SCW1@1236|Gammaproteobacteria,1X7FB@135614|Xanthomonadales 135614|Xanthomonadales IQ acyl carrier protein - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_306379_1 713587.THITH_17160 3.5e-54 177.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1WYDI@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome c, class I - - - - - - - - - - - - Cytochrom_C k59_731133_1 387093.SUN_0537 2.25e-64 218.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2YN0Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_994149_1 1537917.JU82_07105 6.4e-117 345.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2YMPK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_437121_1 472759.Nhal_3208 1.08e-145 429.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1WVYK@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_470207_1 944547.ABLL_2045 5.33e-08 63.5 COG1357@1|root,COG1357@2|Bacteria,1NCWB@1224|Proteobacteria,42WFQ@68525|delta/epsilon subdivisions,2YQN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Pentapeptide repeats (8 copies) - - - - - - - - - - - - Pentapeptide_3 k59_82054_2 1168034.FH5T_07395 1.39e-80 251.0 2EUJZ@1|root,33N1X@2|Bacteria,4NYSW@976|Bacteroidetes,2FVUM@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_638416_1 977880.RALTA_A1537 4.29e-28 107.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VKBQ@28216|Betaproteobacteria,1K39I@119060|Burkholderiaceae 28216|Betaproteobacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_638416_2 381666.H16_A1621 1.03e-38 145.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria,1KBX2@119060|Burkholderiaceae 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_181338_1 1246459.KB898363_gene3218 1.8e-05 51.2 COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2TVQ7@28211|Alphaproteobacteria,4B9MT@82115|Rhizobiaceae 28211|Alphaproteobacteria Q 4-hydroxyphenylacetate 3-hydroxylase C terminal - - - - - - - - - - - - HpaB,HpaB_N k59_605961_1 767434.Fraau_3196 3.71e-63 207.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1X3KZ@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_148724_2 765914.ThisiDRAFT_2078 8e-21 93.2 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_213802_1 1408433.JHXV01000036_gene263 2.28e-05 53.9 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1HXW9@117743|Flavobacteriia,2PBTI@246874|Cryomorphaceae 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_997947_1 1187851.A33M_3785 1.89e-53 177.0 COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2U613@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_23,Methyltransf_25,Ubie_methyltran k59_540833_1 864051.BurJ1DRAFT_0665 2.76e-73 233.0 COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,2VRHM@28216|Betaproteobacteria,1KMT3@119065|unclassified Burkholderiales 28216|Betaproteobacteria CG UDP-glucoronosyl and UDP-glucosyl transferase - - - - - - - - - - - - Glyco_transf_28,UDPGT k59_213809_1 1165841.SULAR_06548 9.89e-129 377.0 COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,42M2P@68525|delta/epsilon subdivisions,2YNS6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Glycosyltransferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_768466_1 163908.KB235895_gene5101 1.64e-110 336.0 COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,1HJR6@1161|Nostocales 1117|Cyanobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_82061_1 941449.dsx2_1165 4.76e-73 237.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Q6R@68525|delta/epsilon subdivisions,2WJN4@28221|Deltaproteobacteria,2M8WF@213115|Desulfovibrionales 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_797750_1 1168034.FH5T_01545 8.17e-148 438.0 COG1894@1|root,COG1894@2|Bacteria,4NFB5@976|Bacteroidetes,2FN7A@200643|Bacteroidia 976|Bacteroidetes C COG1894 NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit nuoF - 1.12.1.3,1.6.5.3 ko:K00335,ko:K18331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_148738_1 1304888.ATWF01000001_gene1398 8.55e-44 162.0 COG3005@1|root,COG3005@2|Bacteria,2GENG@200930|Deferribacteres 200930|Deferribacteres C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_47605_1 1173024.KI912153_gene173 1.62e-103 316.0 COG3464@1|root,COG3464@2|Bacteria,1GKG0@1117|Cyanobacteria,1JM4P@1189|Stigonemataceae 1117|Cyanobacteria L Transposase - - - - - - - - - - - - - k59_473944_1 572544.Ilyop_1221 2.62e-227 642.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,378BF@32066|Fusobacteria 32066|Fusobacteria C PFAM hydrogenase large subunit domain protein - - 1.12.1.2,1.12.1.3 ko:K18006,ko:K18332 - - - - ko00000,ko01000 - - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3 k59_605974_2 1121035.AUCH01000012_gene2923 2.05e-52 169.0 COG4314@1|root,COG4314@2|Bacteria,1N43A@1224|Proteobacteria,2VQI4@28216|Betaproteobacteria,2KWIY@206389|Rhodocyclales 206389|Rhodocyclales C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - NosL k59_12144_16 1049564.TevJSym_aw00510 0.0 964.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,1RMSM@1236|Gammaproteobacteria,1J4JH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_12144_17 1049564.TevJSym_aw00520 1.48e-158 457.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria,1J4V3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_12144_18 1049564.TevJSym_aw00530 4.54e-100 299.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria,1J68A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_12144_19 999541.bgla_1g00240 1.24e-21 87.8 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2VU8S@28216|Betaproteobacteria,1K9JR@119060|Burkholderiaceae 28216|Betaproteobacteria N Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 k59_12144_20 1049564.TevJSym_aw00550 1.87e-116 340.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,1RMYH@1236|Gammaproteobacteria,1J4NZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_12144_21 257313.BP1392 4.32e-08 55.8 COG3190@1|root,COG3190@2|Bacteria,1PQ30@1224|Proteobacteria,2VWHP@28216|Betaproteobacteria,3T4SD@506|Alcaligenaceae 28216|Betaproteobacteria N flagellar fliO - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO k59_12144_22 396595.TK90_1166 3.27e-43 148.0 COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,1S5YE@1236|Gammaproteobacteria,1WYIG@135613|Chromatiales 135613|Chromatiales N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation - - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C k59_12144_23 1049564.TevJSym_aw00580 7.86e-159 455.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,1RQ8M@1236|Gammaproteobacteria,1J4Q8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_12144_24 1049564.TevJSym_aw00590 8.22e-26 104.0 COG1580@1|root,COG1580@2|Bacteria,1N2N9@1224|Proteobacteria,1SAF0@1236|Gammaproteobacteria,1J6I3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL k59_12144_25 335543.Sfum_3450 1.43e-171 494.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria,2MQ4E@213462|Syntrophobacterales 28221|Deltaproteobacteria S Vacuole effluxer Atg22 like - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_12144_26 1430440.MGMSRv2_1216 4.05e-23 89.7 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2UG8Q@28211|Alphaproteobacteria,2JTXJ@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_12144_27 519989.ECTPHS_00085 4.26e-27 104.0 2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria,1WYYH@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_12144_28 765913.ThidrDRAFT_0705 1.71e-159 453.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WX6I@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_12144_29 1260251.SPISAL_01800 9.39e-32 114.0 COG5626@1|root,COG5626@2|Bacteria,1N8QB@1224|Proteobacteria,1SDJI@1236|Gammaproteobacteria,1WZBJ@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF2288) - - - - - - - - - - - - DUF2288 k59_12144_30 2340.JV46_03040 4.94e-100 298.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1J53F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_12144_31 768671.ThimaDRAFT_2051 0.0 1023.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_12144_32 314256.OG2516_11801 8.93e-29 103.0 COG3311@1|root,COG3311@2|Bacteria,1NFRA@1224|Proteobacteria,2UG1W@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Prophage CP4-57 regulatory protein (AlpA) - - - ko:K07733 - - - - ko00000,ko03000 - - - Phage_AlpA k59_12144_34 177439.DP2573 1.34e-124 380.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42VSC@68525|delta/epsilon subdivisions,2WVIT@28221|Deltaproteobacteria,2MNPT@213118|Desulfobacterales 28221|Deltaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_12144_35 1284352.AOIG01000018_gene4388 1.15e-13 81.3 COG2304@1|root,COG2304@2|Bacteria,1V01Q@1239|Firmicutes,4HE4F@91061|Bacilli,26TQZ@186822|Paenibacillaceae 91061|Bacilli S Von Willebrand factor vWFA2 - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_12144_36 502558.EGYY_28700 1.92e-09 69.3 COG1716@1|root,COG1716@2|Bacteria,2HUFE@201174|Actinobacteria,4CUEU@84998|Coriobacteriia 84998|Coriobacteriia T FHA domain - - - - - - - - - - - - DUF3662,FHA,Yop-YscD_cpl k59_12144_37 301.JNHE01000036_gene4321 1.9e-54 189.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1RQUV@1236|Gammaproteobacteria,1YGX4@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_12144_38 35754.JNYJ01000011_gene782 2.48e-10 64.7 COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4DB9K@85008|Micromonosporales 201174|Actinobacteria T FHA domain fhaA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - - - - - - - - - - DUF3662,FHA,Yop-YscD_cpl k59_12144_39 743720.Psefu_0261 2.46e-87 296.0 COG0515@1|root,COG2304@1|root,COG0515@2|Bacteria,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1T1GT@1236|Gammaproteobacteria,1YZKA@136845|Pseudomonas putida group 1236|Gammaproteobacteria H Protein tyrosine kinase ppkA - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - Pkinase k59_12144_40 1121931.AUHG01000010_gene318 8.57e-47 169.0 COG3023@1|root,COG3876@1|root,COG3023@2|Bacteria,COG3876@2|Bacteria,4NIY6@976|Bacteroidetes,1I0U3@117743|Flavobacteriia 976|Bacteroidetes V Protein of unknown function (DUF1343) - - - - - - - - - - - - Amidase_2,DUF1343 k59_12144_41 743720.Psefu_0261 4.47e-86 299.0 COG0515@1|root,COG2304@1|root,COG0515@2|Bacteria,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1T1GT@1236|Gammaproteobacteria,1YZKA@136845|Pseudomonas putida group 1236|Gammaproteobacteria H Protein tyrosine kinase ppkA - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - Pkinase k59_12144_42 13035.Dacsa_3315 3.11e-13 80.9 COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1G102@1117|Cyanobacteria 1117|Cyanobacteria V ABC-type multidrug transport system ATPase component - - - - - - - - - - - - ABC2_membrane,ABC_tran,FHA k59_12144_44 426355.Mrad2831_3027 8.51e-39 156.0 COG0790@1|root,COG4249@1|root,COG0790@2|Bacteria,COG4249@2|Bacteria,1REY7@1224|Proteobacteria,2U87J@28211|Alphaproteobacteria,1JRMM@119045|Methylobacteriaceae 28211|Alphaproteobacteria S peptidase C14 caspase catalytic subunit p20 - - - ko:K07126 - - - - ko00000 - - - Peptidase_C14,Sel1 k59_933201_1 545243.BAEV01000060_gene289 1.79e-256 712.0 COG0366@1|root,COG0366@2|Bacteria,1TR93@1239|Firmicutes,24AB0@186801|Clostridia,36FBK@31979|Clostridiaceae 186801|Clostridia G Sucrose phosphorylase - GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758 2.4.1.329,2.4.1.7 ko:K00690,ko:K21350 ko00500,map00500 - R00803 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase k59_345695_1 96561.Dole_0490 3.77e-13 75.9 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WKJV@28221|Deltaproteobacteria,2MHMF@213118|Desulfobacterales 28221|Deltaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,PA14 k59_277296_1 349124.Hhal_1225 4.41e-14 74.3 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1WYPF@135613|Chromatiales 135613|Chromatiales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_23,SMC_N k59_277296_2 911239.CF149_21148 1.48e-104 315.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_769104_1 1408473.JHXO01000012_gene458 1.93e-139 407.0 COG0389@1|root,COG0389@2|Bacteria,4NII1@976|Bacteroidetes 976|Bacteroidetes L nucleotidyltransferase DNA polymerase involved in DNA repair - - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_769104_2 471854.Dfer_5393 8.22e-71 238.0 COG0587@1|root,COG0587@2|Bacteria,4NGTT@976|Bacteroidetes,47TPJ@768503|Cytophagia 976|Bacteroidetes L DNA polymerase alpha chain like domain - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_246076_1 572544.Ilyop_1080 1.85e-15 73.6 COG2830@1|root,COG2830@2|Bacteria 2|Bacteria S Protein of unknown function (DUF452) bioC - 2.1.1.197,3.1.1.85 ko:K02169,ko:K09789 ko00780,ko01100,map00780,map01100 M00572 R09543,R09725 RC00003,RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - DUF452 k59_246076_2 572544.Ilyop_1081 8.74e-62 194.0 COG1057@1|root,COG1057@2|Bacteria,379PT@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_900007_1 351348.Maqu_2106 7.97e-38 138.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,4673B@72275|Alteromonadaceae 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_115711_1 1165841.SULAR_08944 3.12e-47 168.0 COG4773@1|root,COG4773@2|Bacteria,1QZ1U@1224|Proteobacteria,42PHE@68525|delta/epsilon subdivisions,2YN5J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD k59_474630_1 572477.Alvin_3030 2.32e-50 172.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales 135613|Chromatiales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_474630_2 857087.Metme_0271 1.59e-42 143.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1XEZ2@135618|Methylococcales 135618|Methylococcales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_409460_1 1165841.SULAR_07380 9.64e-48 172.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,42PUG@68525|delta/epsilon subdivisions,2YN09@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB-dependent copper receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_277317_1 555779.Dthio_PD0965 2.52e-46 168.0 COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,430KD@68525|delta/epsilon subdivisions,2WVSS@28221|Deltaproteobacteria 28221|Deltaproteobacteria L High confidence in function and specificity - - - - - - - - - - - - DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind k59_834537_1 1168034.FH5T_05300 4.06e-35 129.0 COG0535@1|root,COG0535@2|Bacteria,4NQ4R@976|Bacteroidetes,2FT2F@200643|Bacteroidia 976|Bacteroidetes C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_834537_2 1168034.FH5T_05305 1.94e-25 105.0 COG0142@1|root,COG1852@1|root,COG0142@2|Bacteria,COG1852@2|Bacteria 2|Bacteria S Protein of unknown function DUF116 ispB - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K02523,ko:K09729,ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - DUF116,polyprenyl_synt k59_933253_1 349124.Hhal_1012 1.15e-49 170.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1WWCM@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_933253_2 243233.MCA0106 6.33e-113 334.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1XE1X@135618|Methylococcales 135618|Methylococcales EH PFAM Aminotransferase, class IV - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_214494_1 596154.Alide2_3903 4.79e-57 192.0 COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2VKFW@28216|Betaproteobacteria,4AH9U@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_214494_2 1254432.SCE1572_38930 3.07e-32 120.0 COG2322@1|root,COG2322@2|Bacteria,1N3YI@1224|Proteobacteria,430G9@68525|delta/epsilon subdivisions,2WVW0@28221|Deltaproteobacteria,2YV26@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF420) - - - ko:K08976 - - - - ko00000 - - - DUF420 k59_606627_1 272558.10173317 2.57e-100 306.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,1ZC02@1386|Bacillus 91061|Bacilli G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_1030067_2 933262.AXAM01000030_gene824 1.34e-16 82.8 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42MD7@68525|delta/epsilon subdivisions,2WJH1@28221|Deltaproteobacteria,2MJF7@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - HD,HD_5,Response_reg k59_541462_1 1172190.M947_01905 3.23e-07 52.8 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2YM8S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_541462_2 1172190.M947_01910 2.53e-90 275.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2YMEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_12221_1 1041142.ATTP01000004_gene4491 3.07e-30 119.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,4BCCP@82115|Rhizobiaceae 28211|Alphaproteobacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - Erythro_esteras,PCMT k59_12221_2 105559.Nwat_2320 2.79e-78 239.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria,1WY8B@135613|Chromatiales 135613|Chromatiales S PFAM SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_735539_1 1121459.AQXE01000005_gene1632 2.1e-86 269.0 COG1055@1|root,COG1055@2|Bacteria,1QUC0@1224|Proteobacteria,42NUZ@68525|delta/epsilon subdivisions,2WJNH@28221|Deltaproteobacteria,2M9FX@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM Sodium sulphate symporter - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_541473_1 221988.MS0761 1.96e-13 75.9 COG3768@1|root,COG3768@2|Bacteria,1MU8S@1224|Proteobacteria,1RND9@1236|Gammaproteobacteria,1Y7MX@135625|Pasteurellales 135625|Pasteurellales S UPF0283 membrane protein Z012_08345 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08990 - - - - ko00000 - - - DUF697 k59_798476_1 1121405.dsmv_0170 1.75e-29 117.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHT0@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_246126_1 269482.Bcep1808_5512 5.16e-10 62.0 COG1953@1|root,COG1953@2|Bacteria,1MV18@1224|Proteobacteria,2VMZR@28216|Betaproteobacteria,1K245@119060|Burkholderiaceae 28216|Betaproteobacteria FH PFAM permease for cytosine purines, uracil, thiamine, allantoin ncs1 - - ko:K03457 - - - - ko00000 2.A.39 - - Transp_cyt_pur k59_149346_1 765912.Thimo_1319 1.3e-128 371.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWQ7@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_214507_1 588581.Cpap_2736 6.01e-07 55.8 COG0157@1|root,COG0157@2|Bacteria,1UYJZ@1239|Firmicutes,24AV1@186801|Clostridia,3WHK9@541000|Ruminococcaceae 186801|Clostridia H Belongs to the NadC ModD family modD - - ko:K03813 - - - - ko00000,ko01000 - - - QRPTase_C,QRPTase_N k59_904542_1 177437.HRM2_01820 6.43e-60 210.0 COG0438@1|root,COG0613@1|root,COG0438@2|Bacteria,COG0613@2|Bacteria,1MUB7@1224|Proteobacteria,42N14@68525|delta/epsilon subdivisions,2WIKT@28221|Deltaproteobacteria,2MIBP@213118|Desulfobacterales 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_708519_1 1121423.JONT01000018_gene164 6.56e-31 121.0 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,266RE@186807|Peptococcaceae 186801|Clostridia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_871245_1 1168034.FH5T_02755 6.11e-45 160.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,4NF25@976|Bacteroidetes,2FSAD@200643|Bacteroidia 976|Bacteroidetes I Phosphate acyltransferases - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_545607_1 1116472.MGMO_155c00170 7.74e-46 153.0 COG0454@1|root,COG0456@2|Bacteria,1PGPM@1224|Proteobacteria,1TC01@1236|Gammaproteobacteria,1XGT3@135618|Methylococcales 135618|Methylococcales K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_120471_4 1355368.JART01000012_gene503 5.17e-31 113.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,42S1N@68525|delta/epsilon subdivisions,2YPJI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin k59_250700_1 484018.BACPLE_00461 1.3e-55 184.0 COG3176@1|root,COG3176@2|Bacteria,4PKEK@976|Bacteroidetes,2FKZ3@200643|Bacteroidia,4AND8@815|Bacteroidaceae 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Acetyltransf_5 k59_413778_1 1499967.BAYZ01000131_gene320 7.01e-92 275.0 COG0395@1|root,COG0395@2|Bacteria 2|Bacteria P glycerophosphodiester transmembrane transport ugpE - - ko:K17323 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - BPD_transp_1 k59_871256_1 765910.MARPU_15070 3.91e-12 66.2 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1WXDW@135613|Chromatiales 135613|Chromatiales G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_871256_2 1249627.D779_0831 9.67e-40 147.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_413787_1 742817.HMPREF9449_01440 2.52e-68 227.0 COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,2FMBR@200643|Bacteroidia,22WPI@171551|Porphyromonadaceae 976|Bacteroidetes L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_1003197_1 379731.PST_0109 6.48e-85 271.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1Z1DQ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_153923_1 1261545.MBE-HAL_0535 5.58e-05 47.0 COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,23SH2@183963|Halobacteria 183963|Halobacteria E COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_153923_2 177437.HRM2_28850 2.45e-31 116.0 COG1456@1|root,COG1456@2|Bacteria,1R9BV@1224|Proteobacteria,42P65@68525|delta/epsilon subdivisions,2WMGX@28221|Deltaproteobacteria,2MHNZ@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF3786) - - - - - - - - - - - - DUF3786,FeS k59_871257_1 983917.RGE_04230 1.74e-65 214.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VMX6@28216|Betaproteobacteria,1KPM0@119065|unclassified Burkholderiales 28216|Betaproteobacteria H AMP-binding enzyme - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_839196_1 1168034.FH5T_17365 5.12e-190 534.0 COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,2FMMZ@200643|Bacteroidia 976|Bacteroidetes G Converts alpha-aldose to the beta-anomer - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_937815_1 1250232.JQNJ01000001_gene2903 1.39e-40 150.0 COG4386@1|root,COG4386@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CHU_C k59_16979_1 765910.MARPU_00830 1.8e-55 196.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_52734_1 1150621.SMUL_1547 2.48e-61 199.0 COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions 1224|Proteobacteria F Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_2242,iSF_1195.SF2059,iSFxv_1172.SFxv_2293,iS_1188.S2169 DBI_PRT k59_87393_1 1123514.KB905899_gene440 5.15e-44 159.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,45ZVI@72273|Thiotrichales 72273|Thiotrichales GM Belongs to the mannose-6-phosphate isomerase type 2 family - - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_315266_1 387093.SUN_0278 5.24e-62 204.0 COG2223@1|root,COG2223@2|Bacteria,1QVWW@1224|Proteobacteria,43CKR@68525|delta/epsilon subdivisions,2YN1B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_446203_1 387093.SUN_0619 1.25e-30 122.0 COG0790@1|root,COG0790@2|Bacteria,1Q4TH@1224|Proteobacteria,42ZV8@68525|delta/epsilon subdivisions,2YRWU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sel1-like repeats. - - - - - - - - - - - - - k59_479172_1 913325.N799_04840 1.22e-21 95.9 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S953@1236|Gammaproteobacteria,1X35M@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - ko:K09921 - - - - ko00000 - - - DUF484 k59_479172_2 265072.Mfla_0196 4.5e-10 60.5 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,2KM39@206350|Nitrosomonadales 206350|Nitrosomonadales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_545631_1 573063.Metin_1333 2.12e-24 105.0 COG1933@1|root,arCOG03147@2157|Archaea,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,23Q0E@183939|Methanococci 183939|Methanococci L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - Intein_splicing,LAGLIDADG_3,PolC_DP2 k59_120499_1 243233.MCA2447 1.24e-72 242.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1XDRZ@135618|Methylococcales 135618|Methylococcales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_803024_1 1168034.FH5T_04125 2.63e-233 652.0 COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes,2FNDJ@200643|Bacteroidia 976|Bacteroidetes E Asparagine synthase, glutamine-hydrolyzing asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_120500_2 935840.JAEQ01000003_gene109 8.05e-11 66.6 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,43JD6@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_52744_1 1168034.FH5T_20290 2.22e-109 328.0 COG1418@1|root,COG1418@2|Bacteria,4NE3V@976|Bacteroidetes,2FKZ6@200643|Bacteroidia 976|Bacteroidetes D Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_937836_1 443143.GM18_0780 2.37e-08 60.8 COG3221@1|root,COG3221@2|Bacteria,1RKH4@1224|Proteobacteria,42SUT@68525|delta/epsilon subdivisions,2WPV0@28221|Deltaproteobacteria 28221|Deltaproteobacteria P TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_52751_1 1168034.FH5T_17385 1.97e-85 264.0 COG0738@1|root,COG0738@2|Bacteria,4NEPI@976|Bacteroidetes,2FP0B@200643|Bacteroidia 976|Bacteroidetes G Transporter, major facilitator family protein gluP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_708564_1 426716.JOAJ01000008_gene4733 2.67e-07 53.5 COG3386@1|root,COG3386@2|Bacteria,2HDRT@201174|Actinobacteria,4FUA4@85025|Nocardiaceae 201174|Actinobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - SGL k59_17001_1 157783.LK03_02455 2.13e-69 229.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_904581_1 1300345.LF41_3150 8.65e-43 148.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1X30T@135614|Xanthomonadales 135614|Xanthomonadales D chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_904581_2 1123400.KB904817_gene1492 3.28e-46 156.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,460R5@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_250730_1 1165841.SULAR_08392 6.78e-131 378.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2YMH9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_446221_2 1473546.CH76_10380 3.52e-18 84.3 COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,4H9WP@91061|Bacilli,3IWER@400634|Lysinibacillus 91061|Bacilli U Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_315284_1 1144325.PMI22_02634 4.63e-11 63.2 COG0835@1|root,COG0835@2|Bacteria,1NA8G@1224|Proteobacteria,1SCB2@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis signal transduction protein chpC - - ko:K06598 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035 - - - CheW k59_315284_2 1226994.AMZB01000122_gene2690 1.17e-50 179.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YEZ2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Signal transducing histidine kinase, homodimeric domain chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_250732_1 1193181.BN10_1010012 1.24e-35 139.0 COG2905@1|root,COG2905@2|Bacteria,2I91C@201174|Actinobacteria,4FEXU@85021|Intrasporangiaceae 201174|Actinobacteria T Putative nucleotidyltransferase DUF294 - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_479191_1 1121439.dsat_0641 4.73e-65 224.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria,2MH87@213115|Desulfovibrionales 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_446227_1 342610.Patl_0198 1.2e-11 67.4 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,2PZW3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O COG0330 Membrane protease subunits, stomatin prohibitin homologs qmcA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Band_7,Band_7_C k59_315289_1 1173020.Cha6605_4495 1.72e-71 231.0 COG5659@1|root,COG5659@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - DDE_5 k59_904599_1 713587.THITH_10665 2.03e-13 69.3 2EKDW@1|root,33E45@2|Bacteria,1NNB2@1224|Proteobacteria 1224|Proteobacteria S Phasin protein - - - - - - - - - - - - Phasin_2 k59_904599_2 522306.CAP2UW1_3919 1e-15 76.3 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,1KQGF@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria IQ KR domain - - 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_479207_1 1232410.KI421418_gene2422 2.18e-59 196.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,43VZ4@69541|Desulfuromonadales 28221|Deltaproteobacteria O SelR domain msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_545671_1 879212.DespoDRAFT_02984 1.31e-35 134.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - ko:K07497 - - - - ko00000 - - - HTH_32,Mu-transpos_C,rve k59_87423_1 743299.Acife_2238 5.15e-05 44.7 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_87423_2 1158292.JPOE01000002_gene1703 5.84e-58 191.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,1KKWV@119065|unclassified Burkholderiales 28216|Betaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_250745_1 1537917.JU82_02640 7.33e-113 331.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2YMV6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_87424_1 420324.KI912069_gene6370 3.07e-69 218.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria,1JYE5@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_677023_1 1280698.AUJS01000083_gene3073 1.47e-08 58.5 COG2801@1|root,COG2801@2|Bacteria,1VUTV@1239|Firmicutes,2501A@186801|Clostridia 186801|Clostridia L Mu transposase, C-terminal - - - - - - - - - - - - Mu-transpos_C k59_839217_1 765911.Thivi_3574 2.34e-63 211.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1WWTY@135613|Chromatiales 135613|Chromatiales FP Belongs to the GppA Ppx family - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_839217_2 395493.BegalDRAFT_2323 2.03e-36 125.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,460R0@72273|Thiotrichales 72273|Thiotrichales C Iron--sulfur cluster insertion protein erpA erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_677028_1 709032.Sulku_0117 1.64e-114 336.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2YN3J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_446255_1 1120951.AUBG01000004_gene2499 1.67e-52 176.0 COG1218@1|root,COG1218@2|Bacteria,4NFHY@976|Bacteroidetes,1HXAV@117743|Flavobacteriia 976|Bacteroidetes P COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_708600_2 1511.CLOST_1542 7.1e-63 207.0 COG0270@1|root,COG0270@2|Bacteria,1TQS8@1239|Firmicutes,24DG1@186801|Clostridia 186801|Clostridia L Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_1034520_1 519989.ECTPHS_03929 2.6e-88 267.0 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind k59_1034520_2 472759.Nhal_0208 2.9e-28 113.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales 135613|Chromatiales F TIGRFAM dihydroorotase, multifunctional complex type - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_17050_1 1168034.FH5T_08780 8.89e-90 273.0 COG0470@1|root,COG0470@2|Bacteria,4NEYF@976|Bacteroidetes,2FPCQ@200643|Bacteroidia 976|Bacteroidetes L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_17050_2 1168034.FH5T_08790 5.17e-67 215.0 COG1774@1|root,COG1774@2|Bacteria,4NENX@976|Bacteroidetes,2FNYP@200643|Bacteroidia 976|Bacteroidetes S PSP1 C-terminal domain protein yaaT - - - - - - - - - - - PSP1 k59_250752_1 1144307.PMI04_00611 2.72e-09 58.9 COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2TSA1@28211|Alphaproteobacteria,2K2MP@204457|Sphingomonadales 204457|Sphingomonadales Q Catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_53429_1 1150621.SMUL_2754 3.85e-84 272.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42NC7@68525|delta/epsilon subdivisions,2YNCX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P E1-E2 ATPase - - - ko:K12950 - - - - ko00000,ko01000 3.A.3.32 - - E1-E2_ATPase,Hydrolase k59_219668_1 159450.NH14_16835 3.59e-65 211.0 COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2VK8A@28216|Betaproteobacteria,1JZYP@119060|Burkholderiaceae 28216|Betaproteobacteria F Imidazolone-5-propionate hydrolase hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_905412_1 1396418.BATQ01000135_gene3630 9.42e-14 70.9 COG0803@1|root,COG0803@2|Bacteria,46TZH@74201|Verrucomicrobia,2IVSM@203494|Verrucomicrobiae 203494|Verrucomicrobiae P Zinc-uptake complex component A periplasmic - - - - - - - - - - - - ZnuA k59_905412_2 1122134.KB893651_gene2386 1.43e-07 51.6 COG3788@1|root,COG3788@2|Bacteria,1RDHP@1224|Proteobacteria,1S3PN@1236|Gammaproteobacteria,1XMH5@135619|Oceanospirillales 135619|Oceanospirillales S relative of glutathione S-transferase, MAPEG superfamily - - - ko:K07136 - - - - ko00000 - - - MAPEG k59_740715_1 545693.BMQ_2765 4.71e-16 77.4 COG3152@1|root,COG3152@2|Bacteria,1VDSW@1239|Firmicutes,4HMMJ@91061|Bacilli,1ZGXZ@1386|Bacillus 91061|Bacilli S Protein of unknown function (DUF805) yhaH - - - - - - - - - - - DUF805 k59_578672_1 1249627.D779_0079 1.05e-75 239.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_53432_1 522306.CAP2UW1_3876 1.67e-90 273.0 COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,2WFCS@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase zinc-ribbon domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_1035046_1 1163409.UUA_08376 6.23e-104 325.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1X3QV@135614|Xanthomonadales 135614|Xanthomonadales C NADH:flavin oxidoreductase / NADH oxidase family - - 1.5.8.1,1.5.8.2 ko:K00317 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R01588,R02511 RC00185,RC00556,RC00557,RC00732 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_774419_1 247490.KSU1_D0176 7.62e-54 184.0 COG1943@1|root,COG1943@2|Bacteria,2IYXS@203682|Planctomycetes 203682|Planctomycetes L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_578678_1 1168034.FH5T_01610 1.12e-106 319.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FMPG@200643|Bacteroidia 976|Bacteroidetes T acetoacetate metabolism regulatory protein AtoC K07714 - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_282512_1 1095769.CAHF01000011_gene2035 7.09e-07 57.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,473HE@75682|Oxalobacteraceae 28216|Betaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_871961_1 572544.Ilyop_0025 5.05e-56 181.0 COG1013@1|root,COG1013@2|Bacteria,37BTB@32066|Fusobacteria 32066|Fusobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_871961_2 1121324.CLIT_18c00260 4.2e-52 169.0 COG1014@1|root,COG1014@2|Bacteria,1UYYG@1239|Firmicutes,24I53@186801|Clostridia,25RBE@186804|Peptostreptococcaceae 186801|Clostridia C 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family - - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,Rubrerythrin k59_774422_1 247490.KSU1_D0636 3.19e-42 154.0 COG0500@1|root,COG0500@2|Bacteria 2|Bacteria Q methyltransferase activity - - - - - - - - - - - - HTH_20,Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_251391_2 95619.PM1_0218230 3e-86 261.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel tolQ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_53450_1 387093.SUN_2068 3e-131 380.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2YN8M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_839833_1 176275.XP_008603622.1 1.36e-05 50.1 COG2319@1|root,COG3325@1|root,KOG0305@2759|Eukaryota,KOG2806@2759|Eukaryota,39V6Q@33154|Opisthokonta,3NZ4H@4751|Fungi,3QPAS@4890|Ascomycota,216H8@147550|Sordariomycetes,3TF1N@5125|Hypocreales 4751|Fungi DO WD40 repeats - GO:0000003,GO:0000075,GO:0000151,GO:0000152,GO:0000280,GO:0003006,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005680,GO:0006508,GO:0006511,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007127,GO:0007129,GO:0007130,GO:0008047,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009272,GO:0009653,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010498,GO:0010604,GO:0010927,GO:0016043,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0022402,GO:0022413,GO:0022414,GO:0022607,GO:0030154,GO:0030163,GO:0030234,GO:0030435,GO:0030437,GO:0030476,GO:0031145,GO:0031323,GO:0031325,GO:0031396,GO:0031398,GO:0031399,GO:0031401,GO:0031461,GO:0031505,GO:0031570,GO:0032268,GO:0032270,GO:0032502,GO:0032505,GO:0032989,GO:0032991,GO:0033313,GO:0034293,GO:0042176,GO:0042244,GO:0042546,GO:0043085,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043632,GO:0043934,GO:0043935,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044703,GO:0044778,GO:0045132,GO:0045143,GO:0045229,GO:0045732,GO:0045786,GO:0048285,GO:0048468,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051276,GO:0051321,GO:0051338,GO:0051347,GO:0051438,GO:0051443,GO:0051603,GO:0051704,GO:0051726,GO:0055106,GO:0060255,GO:0061982,GO:0065007,GO:0065009,GO:0070192,GO:0070193,GO:0070590,GO:0070591,GO:0070726,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071852,GO:0071940,GO:0080090,GO:0097027,GO:0098772,GO:0098813,GO:0140013,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1903046,GO:1903320,GO:1903322,GO:1904666,GO:1904668,GO:1990234,GO:1990757 - ko:K12782 ko04113,map04113 - - - ko00000,ko00001,ko04121 - - - WD40 k59_875174_2 862908.BMS_1128 3.88e-49 161.0 COG1432@1|root,COG1432@2|Bacteria,1QC1U@1224|Proteobacteria,42TAH@68525|delta/epsilon subdivisions,2WPYX@28221|Deltaproteobacteria 28221|Deltaproteobacteria S NYN domain - - - - - - - - - - - - NYN k59_158393_1 999541.bgla_1g07820 4.16e-45 158.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,1JZN1@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_158393_2 519989.ECTPHS_03929 2.42e-19 85.5 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind k59_1038864_2 768671.ThimaDRAFT_3391 1.41e-48 161.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,1WX61@135613|Chromatiales 135613|Chromatiales S PKHD-type hydroxylase - - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_20838_1 382464.ABSI01000012_gene2201 4.37e-83 271.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C k59_190332_1 1049564.TevJSym_bv00150 8.3e-67 210.0 COG1136@1|root,COG1136@2|Bacteria,1RH0D@1224|Proteobacteria,1T21A@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Pfam ABC - - - - - - - - - - - - ABC_tran k59_941617_1 472759.Nhal_1814 1.54e-98 301.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,1X2NN@135613|Chromatiales 135613|Chromatiales CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k59_190333_1 870187.Thini_3774 6.73e-92 289.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,463NI@72273|Thiotrichales 72273|Thiotrichales C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2 k59_318734_1 379066.GAU_3612 4.11e-37 132.0 COG1272@1|root,COG1272@2|Bacteria,1ZTRA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Haemolysin-III related - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_254473_1 1306990.BARG01000018_gene1846 1.37e-82 259.0 COG1609@1|root,COG1609@2|Bacteria,2GK7G@201174|Actinobacteria 201174|Actinobacteria K Rhodopirellula transposase DDE domain - - - - - - - - - - - - DDE_Tnp_ISAZ013,HTH_Tnp_4 k59_417316_1 880072.Desac_0257 1.74e-29 121.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42RS1@68525|delta/epsilon subdivisions,2WNR1@28221|Deltaproteobacteria,2MQVG@213462|Syntrophobacterales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - - - - - - - - - - Na_H_Exchanger,TrkA_N k59_647654_1 497964.CfE428DRAFT_6086 1.49e-75 243.0 COG1283@1|root,COG1283@2|Bacteria,46SD7@74201|Verrucomicrobia 74201|Verrucomicrobia P Na+/Pi-cotransporter - - - - - - - - - - - - Na_Pi_cotrans k59_385983_1 1121104.AQXH01000004_gene63 3.25e-16 83.2 COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes,1IWPE@117747|Sphingobacteriia 976|Bacteroidetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_875194_1 1537917.JU82_04045 3.15e-47 160.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2YN0V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Potassium channel protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_875194_2 1537917.JU82_04050 1.6e-76 240.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2YMJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_91664_1 999141.GME_10356 1.3e-75 241.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1XHRG@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_91664_2 765910.MARPU_00575 9.28e-147 420.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1WW4K@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_1038885_1 768671.ThimaDRAFT_4177 1.09e-43 162.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1WWF0@135613|Chromatiales 135613|Chromatiales I Acyltransferase - - - - - - - - - - - - AMP-binding,Acyltransferase,PP-binding k59_353843_1 1256908.HMPREF0373_02495 2.07e-83 258.0 COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,25VG6@186806|Eubacteriaceae 186801|Clostridia C Pyruvate flavodoxin ferredoxin oxidoreductase, thiamine diP-binding domain protein porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_973517_1 504487.JCM19302_1777 9.59e-112 338.0 COG1132@1|root,COG1132@2|Bacteria,4NEAG@976|Bacteroidetes,1HY1E@117743|Flavobacteriia 976|Bacteroidetes V ABC transporter - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_124377_1 1443125.Z962_03220 3.13e-37 144.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36EFE@31979|Clostridiaceae 186801|Clostridia C Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde - - 2.3.1.54,4.3.99.4 ko:K00656,ko:K20038 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_806743_1 1168034.FH5T_21790 2.5e-44 156.0 COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,2FQQ7@200643|Bacteroidia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family pruA - 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh k59_806743_2 1168034.FH5T_21785 6.82e-36 124.0 COG2919@1|root,COG2919@2|Bacteria,4NURQ@976|Bacteroidetes 976|Bacteroidetes D Septum formation initiator - - - - - - - - - - - - DivIC k59_806743_3 1168034.FH5T_21780 2.26e-85 254.0 COG1678@1|root,COG1678@2|Bacteria,4NFQA@976|Bacteroidetes,2FM82@200643|Bacteroidia 976|Bacteroidetes K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_417321_1 1123400.KB904780_gene1920 4.44e-22 94.7 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_614861_2 580332.Slit_0876 1.24e-08 54.7 COG2703@1|root,COG2703@2|Bacteria,1MZJ3@1224|Proteobacteria,2VVGT@28216|Betaproteobacteria 28216|Betaproteobacteria P PFAM Hemerythrin HHE cation binding domain protein - - - - - - - - - - - - - k59_190342_1 1223410.KN050846_gene1374 1.24e-101 310.0 COG1190@1|root,COG1190@2|Bacteria,4NDZN@976|Bacteroidetes,1HXY4@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF4332,tRNA-synt_2,tRNA_anti-codon k59_20861_1 1249480.B649_11530 4.33e-51 175.0 COG3474@1|root,COG3474@2|Bacteria,1R1KB@1224|Proteobacteria,42Z1J@68525|delta/epsilon subdivisions,2YRH9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c-552 DMSO reductase-like, heme-binding domain - - - ko:K17052 - - - - ko00000,ko02000 5.A.3.8 - - Cytochrom_C,EB_dh k59_582178_1 1121396.KB893069_gene1403 9.04e-104 316.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42N2U@68525|delta/epsilon subdivisions,2WJRR@28221|Deltaproteobacteria,2MI9B@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC transporter transmembrane region - - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_158426_1 1537917.JU82_03735 1.22e-23 96.3 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2YM9D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_158426_2 1165841.SULAR_06388 6.97e-82 245.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2YNVK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_908074_1 1121396.KB893079_gene810 1.42e-16 77.4 COG4241@1|root,COG4241@2|Bacteria,1N4XJ@1224|Proteobacteria,42QCS@68525|delta/epsilon subdivisions,2WKDT@28221|Deltaproteobacteria,2MIFQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2232) - - - - - - - - - - - - DUF2232 k59_908074_2 1121396.KB893079_gene809 1.08e-54 171.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2WR7Z@28221|Deltaproteobacteria,2MKM0@213118|Desulfobacterales 28221|Deltaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_518205_1 563040.Saut_1258 9.83e-128 368.0 COG2048@1|root,COG2048@2|Bacteria,1RFWK@1224|Proteobacteria,43B86@68525|delta/epsilon subdivisions,2YT6P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Heterodisulfide reductase subunit B - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - CCG k59_1007447_1 768671.ThimaDRAFT_1450 1.02e-30 117.0 COG2854@1|root,COG2854@2|Bacteria,1NUHS@1224|Proteobacteria,1SN8R@1236|Gammaproteobacteria,1X0Q3@135613|Chromatiales 135613|Chromatiales Q MlaC protein - - - - - - - - - - - - MlaC k59_319529_1 876044.IMCC3088_2590 4.37e-51 177.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1J4CN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_713124_2 1410620.SHLA_26c000730 6.38e-31 119.0 28H5T@1|root,2Z7IB@2|Bacteria,1N7V9@1224|Proteobacteria,2TTZQ@28211|Alphaproteobacteria,4BA3U@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_286808_1 760154.Sulba_1805 9.67e-45 164.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions 1224|Proteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_807483_1 1121097.JCM15093_2057 2.81e-36 130.0 COG0220@1|root,COG0220@2|Bacteria,4NG4V@976|Bacteroidetes,2FN8Z@200643|Bacteroidia,4ANM9@815|Bacteroidaceae 976|Bacteroidetes J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_807483_2 980584.AFPB01000174_gene1633 2.05e-14 68.6 COG3695@1|root,COG3695@2|Bacteria,4NQ34@976|Bacteroidetes,1I2Y7@117743|Flavobacteriia,4073P@61432|unclassified Flavobacteriaceae 976|Bacteroidetes L 6-O-methylguanine DNA methyltransferase, DNA binding domain ogt - 2.1.1.63 ko:K00567,ko:K07443 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1 k59_92414_2 1565314.OA34_06405 1.33e-28 107.0 2BQ7Q@1|root,32J2F@2|Bacteria,1Q23P@1224|Proteobacteria,42UXU@68525|delta/epsilon subdivisions,2YQ5N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_319536_1 743721.Psesu_0787 3.22e-70 226.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1X349@135614|Xanthomonadales 135614|Xanthomonadales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_319536_2 1444711.CCJF01000004_gene1975 1.11e-07 54.3 COG1043@1|root,COG1043@2|Bacteria,2JFJZ@204428|Chlamydiae 204428|Chlamydiae M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_92417_1 709032.Sulku_0663 6.94e-146 417.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2YMA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM k59_354441_1 1191523.MROS_0765 1.44e-74 236.0 COG2195@1|root,COG2195@2|Bacteria 2|Bacteria E Cleaves the N-terminal amino acid of tripeptides pepT GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M42 k59_843366_1 572544.Ilyop_0384 1.1e-12 68.6 COG0577@1|root,COG0577@2|Bacteria,37A3F@32066|Fusobacteria 32066|Fusobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_286818_1 927658.AJUM01000037_gene2174 5.21e-11 62.0 COG1508@1|root,COG1508@2|Bacteria,4NE5B@976|Bacteroidetes,2FM52@200643|Bacteroidia,3XIQ7@558415|Marinilabiliaceae 976|Bacteroidetes K Sigma-54 factor, Activator interacting domain (AID) rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_286818_2 1168034.FH5T_05870 6.08e-79 240.0 COG0671@1|root,COG0671@2|Bacteria,4NPUG@976|Bacteroidetes,2FUVR@200643|Bacteroidia 976|Bacteroidetes I Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - PAP2 k59_681415_1 1123269.NX02_07745 1.25e-30 125.0 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2K3KA@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_550514_1 273121.WS2089 8.69e-60 198.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2YMK9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase k59_550514_2 1307761.L21SP2_1188 3.32e-06 50.1 COG1291@1|root,COG1291@2|Bacteria,2J5HT@203691|Spirochaetes 203691|Spirochaetes N MotA TolQ ExbB proton channel family motA - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_876058_1 96561.Dole_0671 2.02e-80 251.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2MIJC@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_807499_1 743720.Psefu_4179 1.39e-25 108.0 2AK27@1|root,31ARV@2|Bacteria,1REZR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_21875_1 754476.Q7A_1747 2.74e-61 199.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,1RQSE@1236|Gammaproteobacteria,461KB@72273|Thiotrichales 72273|Thiotrichales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_21875_2 1121405.dsmv_0274 2.03e-35 128.0 COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,42Q98@68525|delta/epsilon subdivisions,2WM5S@28221|Deltaproteobacteria,2MNQ0@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2219) - - - - - - - - - - - - DUF2219 k59_713148_2 485915.Dret_2260 1.14e-15 78.6 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2M898@213115|Desulfovibrionales 2|Bacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388,ko:K03616,ko:K16885,ko:K16886 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored,Fer4,Fer4_4,Fer4_6,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2 k59_550517_1 472759.Nhal_1481 2.03e-63 207.0 COG2403@1|root,COG2403@2|Bacteria,1MV4C@1224|Proteobacteria 1224|Proteobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - - k59_778512_1 1304885.AUEY01000028_gene2811 2.24e-54 180.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,42N1F@68525|delta/epsilon subdivisions,2WK2V@28221|Deltaproteobacteria,2MI0R@213118|Desulfobacterales 28221|Deltaproteobacteria H PFAM Phosphomethylpyrimidine kinase thiD - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00941,ko:K14153,ko:K21219 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2909 Phos_pyr_kin,TMP-TENI,ThiP_synth k59_908901_1 399795.CtesDRAFT_PD1866 1.28e-25 110.0 COG1196@1|root,COG1196@2|Bacteria,1N82P@1224|Proteobacteria,2VX9S@28216|Betaproteobacteria,4AIGN@80864|Comamonadaceae 28216|Betaproteobacteria D domain, Protein - - - - - - - - - - - - - k59_319558_2 1191299.AJYX01000010_gene441 2.37e-29 112.0 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria,1XUNX@135623|Vibrionales 135623|Vibrionales J Belongs to the pseudouridine synthase RsuA family rluE GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_778515_2 1165841.SULAR_08844 2.8e-32 122.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2YMUN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_807506_1 1120999.JONM01000002_gene607 7.02e-09 60.1 COG2199@1|root,COG3706@2|Bacteria,1RD8D@1224|Proteobacteria,2VS5N@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_159380_1 187272.Mlg_2632 1.25e-64 219.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_518963_2 991905.SL003B_1476 1.19e-36 129.0 COG4249@1|root,COG4249@2|Bacteria,1MX7B@1224|Proteobacteria,2TUDI@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidase C14 caspase catalytic subunit p20 MA20_30665 - - - - - - - - - - - Peptidase_C14 k59_518963_3 1026882.MAMP_02759 3.04e-60 198.0 COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,1RMES@1236|Gammaproteobacteria,4626Y@72273|Thiotrichales 72273|Thiotrichales H TOBE domain - - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1,TOBE k59_518963_4 765912.Thimo_0614 3.95e-102 303.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,1WWI7@135613|Chromatiales 135613|Chromatiales P molybdenum ABC transporter, periplasmic - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_518963_5 1249627.D779_4127 1.72e-121 351.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1WWGA@135613|Chromatiales 135613|Chromatiales P TIGRFAM Molybdate ABC transporter - - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_518963_6 580332.Slit_0899 6.63e-119 355.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2VJ3B@28216|Betaproteobacteria,44W54@713636|Nitrosomonadales 28216|Betaproteobacteria P TOBE domain modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_518963_7 580332.Slit_1495 1.17e-19 84.7 COG2920@1|root,COG2920@2|Bacteria,1NAQC@1224|Proteobacteria,2VWA3@28216|Betaproteobacteria 28216|Betaproteobacteria P DsrC like protein - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1007477_1 1123392.AQWL01000008_gene1239 2.86e-49 180.0 COG4447@1|root,COG4447@2|Bacteria,1NRDC@1224|Proteobacteria,2VM3D@28216|Betaproteobacteria 28216|Betaproteobacteria S cellulose binding - - - - - - - - - - - - PSII_BNR k59_440641_2 1123037.AUDE01000001_gene1702 1.39e-39 148.0 COG0517@1|root,COG0517@2|Bacteria,4NGW0@976|Bacteroidetes,1HYC5@117743|Flavobacteriia 976|Bacteroidetes H Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS,GCS2 k59_473633_1 1535422.ND16A_3571 3.4e-165 471.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q707@267889|Colwelliaceae 1236|Gammaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_572520_1 1165841.SULAR_03472 7.17e-21 92.8 COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,42MUQ@68525|delta/epsilon subdivisions,2YMUB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium calcium exchanger membrane - - - ko:K07300 - - - - ko00000,ko02000 2.A.19 - - Na_Ca_ex k59_572520_2 1249480.B649_05870 3.8e-28 112.0 COG0770@1|root,COG0770@2|Bacteria,1Q5GZ@1224|Proteobacteria,42RQ8@68525|delta/epsilon subdivisions,2YP4M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity - - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - - k59_734541_1 90814.KL370891_gene1473 5.25e-41 156.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T239@1236|Gammaproteobacteria,4625C@72273|Thiotrichales 72273|Thiotrichales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_11252_1 1121035.AUCH01000004_gene429 1.11e-76 258.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_213449_1 1165841.SULAR_10139 5.86e-164 471.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2YN8R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_865784_2 483215.BACFIN_08349 4.04e-25 96.3 COG0254@1|root,COG0254@2|Bacteria,4NS7P@976|Bacteroidetes,2FTUG@200643|Bacteroidia,4ARC9@815|Bacteroidaceae 976|Bacteroidetes J Ribosomal protein L31 rpmE2 - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_865784_3 525904.Tter_1654 1.09e-89 279.0 COG0216@1|root,COG0216@2|Bacteria,2NNKY@2323|unclassified Bacteria 2|Bacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02835,ko:K15034 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_540543_2 335543.Sfum_1580 6.98e-67 205.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,2MQGH@213462|Syntrophobacterales 28221|Deltaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_540543_3 1121405.dsmv_3565 2.59e-71 219.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2MIGC@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_81782_1 929558.SMGD1_0988 2.19e-13 64.3 COG0089@1|root,COG0089@2|Bacteria,1QJHM@1224|Proteobacteria,42TRQ@68525|delta/epsilon subdivisions,2YPUJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_81782_2 563040.Saut_0218 1.11e-178 500.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2YN0T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_81782_4 563040.Saut_0220 3.23e-63 194.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2YPJZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_81782_5 563040.Saut_0221 4.77e-57 182.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2YN05@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_47293_1 935863.AWZR01000001_gene1778 1.49e-62 205.0 COG0251@1|root,COG0251@2|Bacteria,1NQGP@1224|Proteobacteria,1S2VU@1236|Gammaproteobacteria,1X33B@135614|Xanthomonadales 135614|Xanthomonadales J pteridine-dependent deoxygenase rapK - 4.1.3.40,4.1.3.45 ko:K18240 ko00130,ko00400,ko01100,ko01110,map00130,map00400,map01100,map01110 M00117 R01302,R10597 RC00491,RC02148,RC03212 ko00000,ko00001,ko00002,ko01000 - - - - k59_213465_1 626418.bglu_1g08910 1.64e-40 145.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2VNMX@28216|Betaproteobacteria,1K072@119060|Burkholderiaceae 28216|Betaproteobacteria I PFAM alpha beta hydrolase fold pldB - 3.1.1.5 ko:K01048 ko00564,map00564 - - - ko00000,ko00001,ko01000 - - - Hydrolase_4 k59_932269_1 574376.BAMA_23670 1.12e-25 98.6 COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,4HH7Z@91061|Bacilli,1ZFKU@1386|Bacillus 91061|Bacilli O Peroxiredoxin bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_932269_2 1033743.CAES01000059_gene4661 2.57e-69 225.0 COG0111@1|root,COG0111@2|Bacteria,1TSDK@1239|Firmicutes,4HAW5@91061|Bacilli,26UH9@186822|Paenibacillaceae 91061|Bacilli EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_932269_3 572544.Ilyop_1417 5.71e-131 374.0 COG0035@1|root,COG0035@2|Bacteria,378U5@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase k59_932269_4 572544.Ilyop_1418 4.63e-33 115.0 COG0254@1|root,COG0254@2|Bacteria,37AJD@32066|Fusobacteria 32066|Fusobacteria J 50S ribosomal protein L31 rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_932269_5 572544.Ilyop_1419 3.57e-104 310.0 COG0328@1|root,COG0328@2|Bacteria,37CTH@32066|Fusobacteria 32066|Fusobacteria L Caulimovirus viroplasmin - - - - - - - - - - - - Cauli_VI k59_276336_1 96561.Dole_2334 5.54e-58 197.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43AF3@68525|delta/epsilon subdivisions,2X5UU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_899098_1 204773.HEAR0175 6.51e-26 111.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,2VSUT@28216|Betaproteobacteria,473G5@75682|Oxalobacteraceae 28216|Betaproteobacteria M LppC putative lipoprotein - - - ko:K07121 - - - - ko00000 - - - LppC k59_376139_1 1168289.AJKI01000012_gene274 4.14e-68 217.0 COG0076@1|root,COG0076@2|Bacteria,4NGRW@976|Bacteroidetes 976|Bacteroidetes E PFAM Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC k59_376139_2 399549.Msed_0300 7.34e-08 57.8 COG0308@1|root,arCOG02969@2157|Archaea,2XPQ3@28889|Crenarchaeota 28889|Crenarchaeota E PBS lyase HEAT domain protein repeat-containing protein - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - HEAT_2,HEAT_PBS,Peptidase_M1 k59_638118_1 879212.DespoDRAFT_00757 1.46e-44 147.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,42REF@68525|delta/epsilon subdivisions,2WQ4F@28221|Deltaproteobacteria,2MK8U@213118|Desulfobacterales 28221|Deltaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_638118_2 933262.AXAM01000013_gene1330 3.88e-28 102.0 COG0291@1|root,COG0291@2|Bacteria,1QDQ4@1224|Proteobacteria,42VSG@68525|delta/epsilon subdivisions,2WREY@28221|Deltaproteobacteria,2MM1F@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_47305_1 94122.Shewana3_2962 1.1e-51 178.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,1RRCR@1236|Gammaproteobacteria,2QB9N@267890|Shewanellaceae 1236|Gammaproteobacteria H Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins - GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018117,GO:0018175,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046983,GO:0070566,GO:0070733,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 - - - - - - - - - - Fic,Fic_N k59_865811_1 1168034.FH5T_05755 5.69e-148 426.0 COG2233@1|root,COG2233@2|Bacteria,4NE5A@976|Bacteroidetes,2FPX6@200643|Bacteroidia 976|Bacteroidetes F permease pyrP - - ko:K02824 - - - - ko00000,ko02000 2.A.40.1.1,2.A.40.1.2 - - Xan_ur_permease k59_932968_1 1168034.FH5T_10335 3.14e-166 484.0 COG0457@1|root,COG0457@2|Bacteria,4NE2V@976|Bacteroidetes,2FXJI@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeats - - - - - - - - - - - - TPR_16,TPR_19,TPR_6,TPR_8 k59_768853_1 1089548.KI783301_gene1802 2.69e-21 97.1 COG3835@1|root,COG3835@2|Bacteria,1TQWD@1239|Firmicutes,4HG6D@91061|Bacilli 91061|Bacilli KT Putative sugar diacid recognition - - - ko:K02647 - - - - ko00000,ko03000 - - - Diacid_rec,HTH_30 k59_1029771_2 1411123.JQNH01000001_gene3862 4.06e-71 219.0 2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,2U6KV@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_899742_1 1121434.AULY01000007_gene1009 1.31e-36 137.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2M8YG@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_345413_1 1177181.T9A_01335 0.00051 43.5 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1XJKB@135619|Oceanospirillales 135619|Oceanospirillales P nucleotidase cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_345413_2 1168034.FH5T_08405 3.03e-16 72.4 2EG8Z@1|root,33A0S@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_998288_1 1347342.BN863_23380 8.22e-45 167.0 COG2304@1|root,COG3291@1|root,COG3391@1|root,COG2304@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,4NDZC@976|Bacteroidetes,1IJ8A@117743|Flavobacteriia 976|Bacteroidetes G Pkd domain containing protein - - - - - - - - - - - - CHU_C,Gal_Lectin,HYR,Laminin_G_3,PKD,SprB,TSP_3 k59_965072_1 748658.KB907312_gene1936 7.75e-77 238.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1WY1K@135613|Chromatiales 135613|Chromatiales P TIGRFAM 3'(2'),5'-bisphosphate nucleotidase - - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_541176_1 163908.KB235896_gene2085 0.000625 48.5 COG0236@1|root,COG1028@1|root,COG3170@1|root,COG3321@1|root,COG0236@2|Bacteria,COG1028@2|Bacteria,COG3170@2|Bacteria,COG3321@2|Bacteria,1G1IB@1117|Cyanobacteria,1HKCF@1161|Nostocales 1117|Cyanobacteria IQ TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt k59_47952_1 314278.NB231_15448 9.88e-48 159.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1WYI3@135613|Chromatiales 135613|Chromatiales S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_47952_2 1300345.LF41_2477 5.61e-17 80.5 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1X3CI@135614|Xanthomonadales 135614|Xanthomonadales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_474288_1 35128.Thaps24542 3.43e-06 54.7 COG5555@1|root,2T2ZP@2759|Eukaryota,2XEEA@2836|Bacillariophyta 2836|Bacillariophyta N Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_998299_1 550540.Fbal_1260 2.22e-67 226.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_82462_1 177437.HRM2_06550 3e-08 53.9 COG3039@1|root,COG3039@2|Bacteria,1R6NB@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1 k59_82462_2 1121405.dsmv_1529 1.93e-42 142.0 COG3415@1|root,COG3415@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - HTH_23,HTH_29,HTH_32,HTH_33 k59_573193_1 941449.dsx2_1623 1.89e-111 335.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Q49@68525|delta/epsilon subdivisions,2X5E9@28221|Deltaproteobacteria,2M8TQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_606353_2 1168034.FH5T_04900 4.24e-100 304.0 COG0726@1|root,COG0726@2|Bacteria,4NF79@976|Bacteroidetes,2FR2H@200643|Bacteroidia 976|Bacteroidetes G polysaccharide deacetylase - - - - - - - - - - - - - k59_345432_2 1033802.SSPSH_002858 8.18e-64 209.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c oxidase accessory protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_1029806_1 933262.AXAM01000053_gene2714 5.43e-50 169.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2MHZ2@213118|Desulfobacterales 28221|Deltaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2261 ATP-grasp_2,Ligase_CoA k59_47980_1 1168034.FH5T_01880 6.59e-99 308.0 COG4206@1|root,COG4206@2|Bacteria,4NHH8@976|Bacteroidetes,2FQ8Y@200643|Bacteroidia 976|Bacteroidetes H TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_409146_1 550540.Fbal_3513 5.11e-109 325.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3939,iBWG_1329.BWG_3608,iECDH10B_1368.ECDH10B_4128,iECDH1ME8569_1439.ECDH1ME8569_3808,iETEC_1333.ETEC_4208,iEcDH1_1363.EcDH1_4046,iEcHS_1320.EcHS_A4172,iEcolC_1368.EcolC_4076,iJO1366.b3939,iJR904.b3939,iUMNK88_1353.UMNK88_4777,iUTI89_1310.UTI89_C4524,iY75_1357.Y75_RS17365 Cys_Met_Meta_PP k59_376887_1 324602.Caur_3875 2.35e-34 131.0 COG1640@1|root,COG1640@2|Bacteria,2G668@200795|Chloroflexi,376Q1@32061|Chloroflexia 32061|Chloroflexia G PFAM glycoside hydrolase, family 77 - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_345440_1 1168034.FH5T_01550 6.33e-86 271.0 COG1520@1|root,COG1520@2|Bacteria,4P1VG@976|Bacteroidetes,2FW8D@200643|Bacteroidia 976|Bacteroidetes S PQQ-like domain - - - - - - - - - - - - PQQ_2 k59_541202_1 396588.Tgr7_0666 1.11e-25 103.0 COG0412@1|root,COG0412@2|Bacteria 2|Bacteria Q carboxymethylenebutenolidase activity - - 3.1.1.45,3.1.1.76 ko:K01061,ko:K22249 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_834265_1 177437.HRM2_24310 2.48e-68 212.0 COG2391@1|root,COG2391@2|Bacteria,1R5DN@1224|Proteobacteria,42RX6@68525|delta/epsilon subdivisions,2WNK5@28221|Deltaproteobacteria,2MJTE@213118|Desulfobacterales 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_834265_2 177437.HRM2_24300 2.71e-53 172.0 COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,42QRV@68525|delta/epsilon subdivisions,2WMUE@28221|Deltaproteobacteria,2MJY2@213118|Desulfobacterales 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_345448_1 574966.KB898652_gene1741 3.55e-13 69.3 COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,1RMZ7@1236|Gammaproteobacteria,1XJDP@135619|Oceanospirillales 135619|Oceanospirillales J synthase truC - 5.4.99.26 ko:K06175 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_2 k59_345448_2 768671.ThimaDRAFT_3213 2.82e-73 243.0 COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WW92@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_933009_1 572544.Ilyop_1262 4.82e-92 283.0 COG0305@1|root,COG0305@2|Bacteria,3784X@32066|Fusobacteria 32066|Fusobacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_933009_2 190304.FN1828 5.3e-43 146.0 COG0359@1|root,COG0359@2|Bacteria,37AIC@32066|Fusobacteria 32066|Fusobacteria J Binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_1029826_1 929558.SMGD1_2181 4.86e-69 220.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2YMPP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H riboflavin biosynthesis protein ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_1029826_2 563040.Saut_0705 4.44e-60 191.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2YN11@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_933010_1 1121875.KB907550_gene639 9.23e-82 272.0 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,SnoaL_3 k59_310573_1 1123511.KB905845_gene2822 1.58e-10 62.4 COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,4H4HY@909932|Negativicutes 909932|Negativicutes S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_310573_3 91464.S7335_5557 2.03e-12 73.9 COG0124@1|root,COG0124@2|Bacteria,1G066@1117|Cyanobacteria,1GZ6V@1129|Synechococcus 1117|Cyanobacteria J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_474343_1 1122179.KB890497_gene2838 1.47e-15 81.3 COG1409@1|root,COG2312@1|root,COG1409@2|Bacteria,COG2312@2|Bacteria,4PP0J@976|Bacteroidetes 976|Bacteroidetes E CotH kinase protein - - - - - - - - - - - - CHB_HEX_C_1,CotH,LTD k59_214221_2 580327.Tthe_2373 2.02e-39 141.0 COG4753@1|root,COG4753@2|Bacteria,1UK30@1239|Firmicutes,25FHN@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - Response_reg k59_577898_1 999419.HMPREF1077_00449 1.23e-110 349.0 COG0085@1|root,COG0085@2|Bacteria,4NF8D@976|Bacteroidetes,2FMDI@200643|Bacteroidia,22X4R@171551|Porphyromonadaceae 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_802849_1 1122978.AUFP01000002_gene2221 8.85e-34 131.0 COG0675@1|root,COG0675@2|Bacteria 2|Bacteria L Transposase, IS605 OrfB family - - - ko:K07496 - - - - ko00000 - - - - k59_802849_2 2754.EH55_04130 2.44e-09 57.4 2DZIB@1|root,32VBF@2|Bacteria 2|Bacteria S Domain of unknown function DUF83 - - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas4 k59_969762_1 556263.FSEG_01853 2.1e-15 71.6 COG0049@1|root,COG0049@2|Bacteria,3790N@32066|Fusobacteria 32066|Fusobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_969762_2 572544.Ilyop_1813 0.0 1165.0 COG0480@1|root,COG0480@2|Bacteria,3785M@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_16729_1 338963.Pcar_2923 8.22e-126 384.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42M86@68525|delta/epsilon subdivisions,2WIT1@28221|Deltaproteobacteria,43TGX@69541|Desulfuromonadales 28221|Deltaproteobacteria V Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - HSDR_N,ResIII k59_52583_1 765914.ThisiDRAFT_0055 4.75e-47 158.0 COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1WX2Z@135613|Chromatiales 135613|Chromatiales E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speD - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_413557_2 1167006.UWK_03541 8.99e-55 183.0 COG3221@1|root,COG3221@2|Bacteria,1NPBT@1224|Proteobacteria,42NX8@68525|delta/epsilon subdivisions,2WM7I@28221|Deltaproteobacteria,2MIUZ@213118|Desulfobacterales 28221|Deltaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_802851_1 240016.ABIZ01000001_gene131 3.49e-73 243.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_9 k59_802851_2 768671.ThimaDRAFT_0848 2.68e-16 76.3 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K response regulator - - - - - - - - - - - - GerE,Response_reg,Trans_reg_C k59_478896_1 891968.Anamo_1313 4.28e-57 191.0 COG2379@1|root,COG2379@2|Bacteria,3TARB@508458|Synergistetes 508458|Synergistetes G Domain of unknown function (DUF4147) - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_250488_1 1123073.KB899241_gene1857 1.04e-51 173.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1X3FN@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_250488_2 751994.AGIG01000028_gene1608 3.17e-07 51.2 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1J4P1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_838981_1 709991.Odosp_0033 4.77e-144 421.0 COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,2FNXT@200643|Bacteroidia,22X3P@171551|Porphyromonadaceae 976|Bacteroidetes S Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_838981_2 1408473.JHXO01000012_gene382 1.28e-37 138.0 COG2160@1|root,COG2160@2|Bacteria,4NHGG@976|Bacteroidetes,2FMIU@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the conversion of L-arabinose to L-ribulose araA - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Iso_C,Arabinose_Isome k59_904373_1 1322246.BN4_11156 3.34e-134 406.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2M81W@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM,DctQ k59_904373_2 240302.BN982_01173 1.07e-31 119.0 COG3090@1|root,COG3090@2|Bacteria,1V3PZ@1239|Firmicutes,4HI3P@91061|Bacilli 91061|Bacilli G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_904373_3 401526.TcarDRAFT_0677 2.73e-114 342.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,4H3G3@909932|Negativicutes 909932|Negativicutes G TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - - - - - - - - - - DctP k59_904373_4 469616.FMAG_00412 2.33e-80 247.0 COG2186@1|root,COG2186@2|Bacteria,37AVS@32066|Fusobacteria 32066|Fusobacteria K FCD - - - - - - - - - - - - FCD,GntR k59_904373_5 1319815.HMPREF0202_02455 1.31e-45 160.0 COG2721@1|root,COG2721@2|Bacteria,378ZM@32066|Fusobacteria 32066|Fusobacteria G SAF - - 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_643453_1 1484460.JSWG01000009_gene300 2.6e-81 255.0 COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes,1HZHR@117743|Flavobacteriia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_904377_1 1249480.B649_11555 8.68e-33 117.0 2AJ5V@1|root,319QG@2|Bacteria,1Q3K7@1224|Proteobacteria,42XFR@68525|delta/epsilon subdivisions,2YQU7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_904377_2 1537917.JU82_07135 4.17e-47 161.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2YRAH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - ParA k59_676829_1 929558.SMGD1_2400 1.06e-29 114.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2YNSU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_676829_2 640081.Dsui_1956 9.71e-11 60.5 COG0607@1|root,COG0607@2|Bacteria,1N5D7@1224|Proteobacteria,2VVDJ@28216|Betaproteobacteria,2KXM3@206389|Rhodocyclales 206389|Rhodocyclales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_218791_1 177437.HRM2_05830 7.7e-54 182.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2MICK@213118|Desulfobacterales 28221|Deltaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_708359_2 1165841.SULAR_08597 1.27e-52 179.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2YMWG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U COG1459 Type II secretory pathway, component PulF - - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_315117_1 324057.Pjdr2_0698 6.98e-17 87.0 COG3170@1|root,COG4099@1|root,COG4932@1|root,COG3170@2|Bacteria,COG4099@2|Bacteria,COG4932@2|Bacteria,1UJE7@1239|Firmicutes,4IT6J@91061|Bacilli,2778B@186822|Paenibacillaceae 91061|Bacilli M S-layer homology domain - - - - - - - - - - - - CarboxypepD_reg,SLH k59_478943_1 387093.SUN_0583 3.17e-62 211.0 COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2YNBS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,ResIII k59_676838_1 414684.RC1_0273 2.58e-70 240.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JQH0@204441|Rhodospirillales 204441|Rhodospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_153762_1 396588.Tgr7_2268 3.01e-48 162.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales 135613|Chromatiales S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_153762_2 1249627.D779_0277 1.07e-39 145.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_839027_1 748658.KB907313_gene2401 3.99e-67 228.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WZVH@135613|Chromatiales 135613|Chromatiales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF k59_413593_1 1454010.JEOE01000002_gene500 1.25e-95 281.0 299E4@1|root,2ZWGX@2|Bacteria,2GM90@201174|Actinobacteria,4F173@85016|Cellulomonadaceae 201174|Actinobacteria S Protein of unknown function (DUF3145) - - - - - - - - - - - - DUF3145 k59_52602_1 572544.Ilyop_0567 1.47e-271 754.0 COG0111@1|root,COG0111@2|Bacteria,37CUC@32066|Fusobacteria 32066|Fusobacteria C D-isomer specific 2-hydroxyacid dehydrogenase catalytic region - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_52602_2 1443125.Z962_09705 5.14e-64 199.0 COG0537@1|root,COG0537@2|Bacteria,1VAE2@1239|Firmicutes,25BC4@186801|Clostridia,36I8S@31979|Clostridiaceae 186801|Clostridia FG Histidine triad (HIT) protein - - - - - - - - - - - - HIT k59_52602_3 1319815.HMPREF0202_00211 3.13e-66 207.0 COG0622@1|root,COG0622@2|Bacteria,379XS@32066|Fusobacteria 32066|Fusobacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_52602_4 265729.GS18_0200985 2e-160 469.0 COG1502@1|root,COG1502@2|Bacteria,1TQ2Q@1239|Firmicutes,4H9SX@91061|Bacilli,1ZBA2@1386|Bacillus 91061|Bacilli I PLD-like domain cls2 - - - - - - - - - - - PLDc_2 k59_52602_5 246194.CHY_0441 1.24e-57 188.0 COG0517@1|root,COG1349@1|root,COG0517@2|Bacteria,COG1349@2|Bacteria,1TRZD@1239|Firmicutes,24851@186801|Clostridia,42G3J@68295|Thermoanaerobacterales 186801|Clostridia K Domain in cystathionine beta-synthase and other proteins. ccpN - - - - - - - - - - - CBS,HTH_11 k59_52602_6 1443125.Z962_07530 1.17e-49 160.0 2EJBW@1|root,33D30@2|Bacteria,1VDH3@1239|Firmicutes,24JQ8@186801|Clostridia,36K19@31979|Clostridiaceae 186801|Clostridia S Putative redox-active protein (C_GCAxxG_C_C) - - - - - - - - - - - - C_GCAxxG_C_C k59_52602_7 545243.BAEV01000030_gene444 1.01e-232 653.0 COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,36E2U@31979|Clostridiaceae 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_52602_8 545243.BAEV01000030_gene445 1.39e-237 666.0 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,36DQW@31979|Clostridiaceae 186801|Clostridia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_52602_9 272562.CA_C2978 4.29e-34 119.0 COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24R1Z@186801|Clostridia,36MPK@31979|Clostridiaceae 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_52602_10 1294142.CINTURNW_3275 3.08e-209 590.0 COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,248XN@186801|Clostridia,36FC0@31979|Clostridiaceae 186801|Clostridia J L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp aspS - 6.1.1.12,6.1.1.23 ko:K01876,ko:K09759 ko00970,map00970 M00359,M00360 R03647,R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - tRNA-synt_2,tRNA_anti-codon k59_839038_1 572544.Ilyop_1111 3.22e-141 408.0 COG0763@1|root,COG0763@2|Bacteria,378RI@32066|Fusobacteria 32066|Fusobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_839038_2 469615.FGAG_00332 9.28e-53 174.0 COG3494@1|root,COG3494@2|Bacteria,378EG@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - ko:K09949 - - - - ko00000 - - - DUF1009 k59_350087_1 50452.W0USQ7 9.49e-142 410.0 28ISP@1|root,2QR3X@2759|Eukaryota,37T53@33090|Viridiplantae,3G7SE@35493|Streptophyta,3HVWC@3699|Brassicales 35493|Streptophyta C One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light- driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation psbC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009521,GO:0009523,GO:0009532,GO:0009533,GO:0009534,GO:0009535,GO:0009536,GO:0009539,GO:0009570,GO:0009579,GO:0010287,GO:0016020,GO:0031976,GO:0031984,GO:0032991,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0098796 - ko:K02705 ko00195,ko01100,map00195,map01100 M00161 - - ko00000,ko00001,ko00002,ko00194 - - - PSII k59_350087_2 59689.fgenesh2_kg.2__723__ATCG00270.1 5.06e-166 469.0 2CNIT@1|root,2QWJF@2759|Eukaryota,37RZQ@33090|Viridiplantae,3GF68@35493|Streptophyta 35493|Streptophyta C Photosystem II (PSII) is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1 D2 (PsbA PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex psbD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0010287,GO:0016020,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 1.10.3.9 ko:K02706 ko00195,ko01100,map00195,map01100 M00161 - - ko00000,ko00001,ko00002,ko00194,ko01000 - - - Photo_RC k59_446075_1 1168034.FH5T_17755 3.31e-76 242.0 COG0591@1|root,COG0591@2|Bacteria,4NH7H@976|Bacteroidetes 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307,ko:K14387 ko04725,ko05231,map04725,map05231 - - - ko00000,ko00001,ko02000 2.A.21,2.A.21.8 - - HD_4,SSF k59_218816_1 1242864.D187_002120 1.37e-42 158.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - - k59_610866_1 998088.B565_2361 9.26e-124 389.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1Y3MV@135624|Aeromonadales 135624|Aeromonadales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_350089_1 644282.Deba_0485 1.29e-05 46.6 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1,dCache_2,dCache_3,sCache_2 k59_708384_1 991905.SL003B_2771 1.05e-13 65.5 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2UFC1@28211|Alphaproteobacteria 28211|Alphaproteobacteria P sulfurtransferase - - - - - - - - - - - - DUF2892 k59_350093_1 290317.Cpha266_0617 3.97e-32 127.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1FDBJ@1090|Chlorobi 1090|Chlorobi T histidine kinase A domain protein - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,Response_reg,dCache_3 k59_52617_1 497965.Cyan7822_4932 1.33e-44 163.0 COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,1G00D@1117|Cyanobacteria,3KH66@43988|Cyanothece 1117|Cyanobacteria PT Sodium hydrogen exchanger nhaS5 - - - - - - - - - - - Na_H_Exchanger,Usp k59_969841_1 511062.GU3_10000 1.34e-40 144.0 COG0131@1|root,COG0241@1|root,COG0131@2|Bacteria,COG0241@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1Y3YD@135624|Aeromonadales 135624|Aeromonadales E belongs to the histidinol- phosphatase family hisB - 3.1.3.15,4.2.1.19 ko:K01089 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - - Hydrolase_like,IGPD,PNK3P k59_969841_2 1384056.N787_11670 3.14e-40 139.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1X5IB@135614|Xanthomonadales 135614|Xanthomonadales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_904423_1 879212.DespoDRAFT_03188 2.46e-115 333.0 COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria,2MJDS@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF374) - - - ko:K09778 - - - - ko00000 - - - DUF374 k59_708390_1 1537915.JU57_11910 2.16e-35 122.0 COG2161@1|root,COG2161@2|Bacteria,1N6X6@1224|Proteobacteria,42VPC@68525|delta/epsilon subdivisions,2YQD8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Antitoxin component of a toxin-antitoxin (TA) module - - - ko:K19159 - - - - ko00000,ko02048 - - - PhdYeFM_antitox k59_708390_2 521393.JH806634_gene2277 2.37e-27 102.0 COG4115@1|root,COG4115@2|Bacteria,2IQAJ@201174|Actinobacteria,4D6BX@85005|Actinomycetales 201174|Actinobacteria S addiction module toxin, Txe YoeB family - - - ko:K19158 - - - - ko00000,ko01000,ko02048 - - - YoeB_toxin k59_839061_1 1121887.AUDK01000015_gene857 3.26e-106 329.0 COG0702@1|root,COG0702@2|Bacteria,4NG5U@976|Bacteroidetes,1I0T9@117743|Flavobacteriia,2NSG8@237|Flavobacterium 976|Bacteroidetes GM PFAM SusD family - - - - - - - - - - - - SusD-like_3,SusD_RagB k59_937686_1 96561.Dole_0171 1.64e-83 265.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2MIZF@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ABC transporter uup - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_446090_1 1249627.D779_0258 1.02e-126 383.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales 135613|Chromatiales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_577963_1 709032.Sulku_2492 6.53e-136 397.0 COG2897@1|root,COG2897@2|Bacteria,1PI99@1224|Proteobacteria,42PX2@68525|delta/epsilon subdivisions,2YNFU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_577963_2 1249480.B649_11540 8.5e-58 198.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,43BQI@68525|delta/epsilon subdivisions,2YRHF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K17050 - - - - ko00000,ko02000 5.A.3.8 - - Molybdopterin,Molydop_binding k59_1003039_1 246197.MXAN_2052 5.45e-14 73.6 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2WN8H@28221|Deltaproteobacteria,2YVAS@29|Myxococcales 28221|Deltaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1003039_2 926561.KB900620_gene3214 9.5e-07 48.1 COG0690@1|root,COG0690@2|Bacteria,1VK48@1239|Firmicutes,24UI4@186801|Clostridia,3WAYQ@53433|Halanaerobiales 186801|Clostridia U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_1003039_3 1089553.Tph_c26090 9.59e-65 204.0 COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,42FYD@68295|Thermoanaerobacterales 186801|Clostridia K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_1003039_4 1408415.JHXL01000002_gene254 6.24e-30 110.0 COG0080@1|root,COG0080@2|Bacteria,3WTDP@544448|Tenericutes 544448|Tenericutes J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_250568_1 1121374.KB891591_gene3433 7.65e-68 217.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1S059@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_31 k59_871123_1 219305.MCAG_03527 4.06e-37 138.0 COG1028@1|root,COG1028@2|Bacteria,2I32I@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_281679_1 76114.ebA7259 1.66e-71 225.0 28H75@1|root,2Z7JG@2|Bacteria,1MU3Y@1224|Proteobacteria,2VNKC@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage major capsid protein E - - - - - - - - - - - - Phage_cap_E k59_120387_1 2074.JNYD01000003_gene3984 2.87e-54 183.0 COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4DYFX@85010|Pseudonocardiales 201174|Actinobacteria E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_413628_2 525373.HMPREF0766_14439 9.45e-21 82.8 COG0230@1|root,COG0230@2|Bacteria,4NUTV@976|Bacteroidetes 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 k59_1034922_1 1300345.LF41_1635 1.54e-94 296.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales 135614|Xanthomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_677524_1 886293.Sinac_0727 2.27e-17 84.3 COG2730@1|root,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process - - 3.2.1.123 ko:K05991 - - - - ko00000,ko01000 - GH5 - Cellulase k59_546134_1 196367.JNFG01000006_gene7061 5.28e-64 222.0 COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,1K40G@119060|Burkholderiaceae 28216|Betaproteobacteria C FAD linked oxidase domain protein glpCD - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_611584_2 314262.MED193_08208 3.51e-26 104.0 COG4948@1|root,COG4948@2|Bacteria,1R63G@1224|Proteobacteria,2TT3A@28211|Alphaproteobacteria,2P201@2433|Roseobacter 28211|Alphaproteobacteria M COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_154495_1 768671.ThimaDRAFT_1369 5.14e-120 368.0 COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,1RMJS@1236|Gammaproteobacteria,1WW9Q@135613|Chromatiales 135613|Chromatiales C belongs to the CobB CobQ family - - 2.3.1.8 ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,DRTGG,PTA_PTB k59_282340_1 1537917.JU82_08380 2.06e-99 297.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,42ND2@68525|delta/epsilon subdivisions,2YMQ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_2 k59_382174_1 1288963.ADIS_2096 1.17e-84 268.0 COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,4NEZJ@976|Bacteroidetes,47NF5@768503|Cytophagia 976|Bacteroidetes P Sulfatase - - - - - - - - - - - - HEAT_2,Sulfatase k59_53323_1 1168034.FH5T_07265 8.59e-109 332.0 COG4206@1|root,COG4206@2|Bacteria,4NHH8@976|Bacteroidetes,2FM70@200643|Bacteroidia 976|Bacteroidetes H COG COG4771 Outer membrane receptor for ferrienterochelin and colicins - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_414351_1 269799.Gmet_1894 1.02e-19 93.6 COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria,43T50@69541|Desulfuromonadales 28221|Deltaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity recC - 3.1.11.5 ko:K03583 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_V_gamma k59_774288_1 1049564.TevJSym_aa01440 6.45e-65 202.0 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,1SBMS@1236|Gammaproteobacteria,1JBHM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,Redoxin k59_905253_1 269799.Gmet_0150 5.26e-70 215.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen prx-4 - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_970584_2 1370121.AUWS01000023_gene2195 2.56e-06 53.9 COG1309@1|root,COG1309@2|Bacteria,2HK4X@201174|Actinobacteria,234WZ@1762|Mycobacteriaceae 201174|Actinobacteria K transcriptional kstR2 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0042803,GO:0046983,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K22108 - - - - ko00000,ko03000 - - - TetR_C_4,TetR_N k59_942047_1 1131553.JIBI01000001_gene1482 3.9e-35 130.0 COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,2VJXX@28216|Betaproteobacteria 28216|Betaproteobacteria S Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - DUF389 k59_942047_2 326298.Suden_0834 2.67e-33 115.0 2DPGY@1|root,3320R@2|Bacteria,1ND7F@1224|Proteobacteria,431RD@68525|delta/epsilon subdivisions 1224|Proteobacteria S Protein of unknown function (DUF3185) - - - - - - - - - - - - DUF3185 k59_942047_3 760154.Sulba_1043 4.18e-06 48.9 2DNS2@1|root,32YVY@2|Bacteria,1N9QQ@1224|Proteobacteria,42X5E@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - k59_942047_4 1150621.SMUL_1667 5.25e-19 78.6 2AJJC@1|root,31A66@2|Bacteria,1Q50N@1224|Proteobacteria,42WPC@68525|delta/epsilon subdivisions,2YQDR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_875744_1 588581.Cpap_0544 1.79e-15 77.4 COG1404@1|root,COG3209@1|root,COG1404@2|Bacteria,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,3WIU1@541000|Ruminococcaceae 186801|Clostridia M RHS Repeat - - - - - - - - - - - - Peptidase_S8,RHS_repeat k59_712766_1 552811.Dehly_1535 9.98e-51 172.0 COG3547@1|root,COG3547@2|Bacteria,2G8GZ@200795|Chloroflexi 200795|Chloroflexi L transposase IS116 IS110 IS902 family protein - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_417872_1 1502851.FG93_04631 1.44e-140 413.0 COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria,3JX1U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214,DUF1254 k59_518683_1 1165841.SULAR_07585 1.58e-43 161.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 k59_1039479_1 930169.B5T_01691 3.27e-33 120.0 COG1943@1|root,COG1943@2|Bacteria,1MZZT@1224|Proteobacteria,1S9JG@1236|Gammaproteobacteria,1XKZM@135619|Oceanospirillales 135619|Oceanospirillales L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - Y1_Tnp k59_124867_2 272559.BF9343_0018 1.43e-07 57.4 COG4773@1|root,COG4773@2|Bacteria,4NF92@976|Bacteroidetes,2FQRT@200643|Bacteroidia,4APSX@815|Bacteroidaceae 976|Bacteroidetes P Carboxypeptidase regulatory-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_417889_1 396588.Tgr7_3011 8.12e-45 156.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1WX49@135613|Chromatiales 135613|Chromatiales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_319184_1 1121918.ARWE01000001_gene350 8.18e-73 235.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,43SU0@69541|Desulfuromonadales 28221|Deltaproteobacteria H thiamine pyrophosphate protein TPP binding domain protein - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_319184_2 1121918.ARWE01000001_gene349 6.42e-47 155.0 COG0440@1|root,COG0440@2|Bacteria 2|Bacteria E acetolactate synthase activity ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_190879_1 317025.Tcr_0513 3.59e-70 234.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,46054@72273|Thiotrichales 72273|Thiotrichales G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_92139_1 754436.JCM19237_425 1.94e-16 81.3 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XSZN@135623|Vibrionales 135623|Vibrionales U Involved in the TonB-independent uptake of proteins tolB GO:0003674,GO:0005215 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_974004_1 493475.GARC_1986 2.13e-59 196.0 COG0577@1|root,COG0577@2|Bacteria,1PVW8@1224|Proteobacteria,1SZYK@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX k59_92141_2 555779.Dthio_PD3188 2.35e-24 102.0 COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,431TI@68525|delta/epsilon subdivisions,2WWAP@28221|Deltaproteobacteria,2MB98@213115|Desulfovibrionales 28221|Deltaproteobacteria L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338 k59_615308_1 314345.SPV1_13357 1.5e-26 118.0 COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,1MZV7@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_875770_1 563040.Saut_0318 1.98e-175 528.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2YMMS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_159010_1 485917.Phep_2743 6.92e-30 117.0 COG1649@1|root,COG1649@2|Bacteria,4NJ45@976|Bacteroidetes,1IPI1@117747|Sphingobacteriia 976|Bacteroidetes S Sialate O-acetylesterase - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - SASA k59_159010_2 1268240.ATFI01000010_gene1563 1.76e-16 79.3 COG1554@1|root,COG1554@2|Bacteria,4NHVP@976|Bacteroidetes,2FMGG@200643|Bacteroidia,4AKSQ@815|Bacteroidaceae 976|Bacteroidetes G hydrolase, family 65, central catalytic - - - - - - - - - - - - - k59_354225_1 292415.Tbd_0489 1.74e-89 268.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,1KRBM@119069|Hydrogenophilales 119069|Hydrogenophilales S Inhibitor of apoptosis-promoting Bax1 - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_875772_1 223926.28808950 1.33e-18 91.3 COG1345@1|root,COG4412@1|root,COG1345@2|Bacteria,COG4412@2|Bacteria,1RKAD@1224|Proteobacteria,1S8JD@1236|Gammaproteobacteria,1XSHD@135623|Vibrionales 135623|Vibrionales Q Immune inhibitor A peptidase M6 - - - - - - - - - - - - Peptidase_M6 k59_254993_2 1537917.JU82_11220 1.17e-78 246.0 COG1651@1|root,COG1651@2|Bacteria,1RFRJ@1224|Proteobacteria,42SPD@68525|delta/epsilon subdivisions,2YP88@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - - - - - - - - - - - Thioredoxin_4 k59_843087_1 96561.Dole_2289 2.46e-30 120.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_843087_2 96561.Dole_0226 9.86e-12 62.8 COG3255@1|root,COG3255@2|Bacteria,1NUMH@1224|Proteobacteria,42ZHK@68525|delta/epsilon subdivisions,2WUZ2@28221|Deltaproteobacteria,2MNBX@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM Sterol-binding domain protein - - - - - - - - - - - - SCP2 k59_974008_1 1184267.A11Q_187 9.03e-36 138.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2MSRI@213481|Bdellovibrionales,2WJKC@28221|Deltaproteobacteria 213481|Bdellovibrionales M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_159684_2 666686.B1NLA3E_06840 1.34e-55 192.0 COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1TPKU@1239|Firmicutes,4H9KR@91061|Bacilli,1ZAVB@1386|Bacillus 91061|Bacilli GT COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) fruA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563 2.7.1.202 ko:K02768,ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB k59_778728_1 2340.JV46_23640 3e-08 55.1 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase domain gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_778728_2 1249627.D779_0856 4.04e-96 293.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_125415_1 870187.Thini_1237 3.49e-79 250.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,45ZTP@72273|Thiotrichales 72273|Thiotrichales S Flavocytochrome c sulphide dehydrogenase, flavin-binding - - 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2 k59_191460_1 1229783.C273_05405 5.25e-12 70.9 COG3949@1|root,COG3949@2|Bacteria,1V153@1239|Firmicutes,4HD7J@91061|Bacilli,4H1H9@90964|Staphylococcaceae 91061|Bacilli S Membrane - - - - - - - - - - - - - k59_681668_1 411902.CLOBOL_02000 4.65e-37 139.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,21XGE@1506553|Lachnoclostridium 186801|Clostridia P Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_57962_1 550540.Fbal_1708 1.69e-42 148.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria 1236|Gammaproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0033554,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051716,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_0850,iSDY_1059.SDY_2217 His_biosynth k59_843611_1 439235.Dalk_4747 1.25e-34 133.0 COG5380@1|root,COG5380@2|Bacteria,1RKYE@1224|Proteobacteria,42SPR@68525|delta/epsilon subdivisions,2WPY0@28221|Deltaproteobacteria,2MK88@213118|Desulfobacterales 28221|Deltaproteobacteria O Proteobacterial lipase chaperone protein - - - - - - - - - - - - Lipase_chap k59_223831_1 929558.SMGD1_0321 4.19e-135 422.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2YMRQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_255615_1 264730.PSPPH_A0100 5.2e-158 455.0 COG3293@1|root,COG3293@2|Bacteria,1R9R1@1224|Proteobacteria,1S1JV@1236|Gammaproteobacteria 1236|Gammaproteobacteria L transposase (DDE domain) - - - - - - - - - - - - DDE_Tnp_1,DUF4096,HTH_Tnp_Tc3_2 k59_223835_1 236097.ADG881_1942 2.29e-32 125.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XHWB@135619|Oceanospirillales 135619|Oceanospirillales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE k59_223835_2 1268237.G114_14056 1.05e-12 68.2 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1Y3IJ@135624|Aeromonadales 135624|Aeromonadales U General secretion pathway protein F exeF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_255619_1 323850.Shew_2105 6.12e-22 90.1 COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,1SCIZ@1236|Gammaproteobacteria,2QCE4@267890|Shewanellaceae 1236|Gammaproteobacteria L PFAM Methylated-DNA- protein -cysteine S-methyltransferase ybaZ GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 - ko:K07443 - - - - ko00000 - - - DNA_binding_1 k59_255619_2 269799.Gmet_0792 6.39e-26 100.0 COG2945@1|root,COG2945@2|Bacteria,1QY8I@1224|Proteobacteria,43CAB@68525|delta/epsilon subdivisions,2X7KV@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - - k59_648730_1 631362.Thi970DRAFT_03477 2.88e-84 267.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales 135613|Chromatiales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1040018_1 1192034.CAP_4377 1.72e-55 196.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1PXKK@1224|Proteobacteria,430EF@68525|delta/epsilon subdivisions,2WVY2@28221|Deltaproteobacteria,2YWBP@29|Myxococcales 28221|Deltaproteobacteria Q polyketide synthase - - - ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_125437_1 1121405.dsmv_3691 8.07e-147 424.0 COG3547@1|root,COG3547@2|Bacteria,1NP2U@1224|Proteobacteria,43A5Q@68525|delta/epsilon subdivisions,2X2AM@28221|Deltaproteobacteria,2MPDW@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - - k59_255626_1 305700.B447_07137 4.45e-64 211.0 COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales 206389|Rhodocyclales G BT1 family - - - - - - - - - - - - BT1 k59_57977_1 13333.ERM96121 1.9e-82 245.0 COG0100@1|root,KOG0408@2759|Eukaryota,37UVR@33090|Viridiplantae,3GJ9B@35493|Streptophyta 35493|Streptophyta J Belongs to the universal ribosomal protein uS11 family rps11 GO:0000028,GO:0000313,GO:0000314,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0031974,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070013,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0098798,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_57977_2 4113.PGSC0003DMT400036532 4.45e-178 501.0 COG0202@1|root,2QRS7@2759|Eukaryota,37QVG@33090|Viridiplantae,3GHDB@35493|Streptophyta,44N87@71274|asterids 35493|Streptophyta K Bacterial RNA polymerase, alpha chain C terminal domain rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009507,GO:0009532,GO:0009534,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0031976,GO:0031984,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_125438_1 1225184.ALXE01000033_gene3174 7.95e-47 165.0 COG1082@1|root,COG1082@2|Bacteria,1NISG@1224|Proteobacteria,1S0FC@1236|Gammaproteobacteria,3W2RS@53335|Pantoea 1236|Gammaproteobacteria G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_255631_1 1485544.JQKP01000002_gene1389 9.35e-75 245.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,44VKP@713636|Nitrosomonadales 28216|Betaproteobacteria C Malic enzyme, NAD binding domain maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malate_DH,Malic_M,PTA_PTB,malic k59_583241_1 675817.VDA_000974 5.56e-39 140.0 COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,1S2RR@1236|Gammaproteobacteria,1XUN1@135623|Vibrionales 135623|Vibrionales S TPM domain - - - ko:K08988 - - - - ko00000 - - - TPM_phosphatase k59_778762_1 648885.KB316283_gene2919 1.46e-18 88.6 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,1JRKS@119045|Methylobacteriaceae 28211|Alphaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_519215_1 3880.AES69829 2.62e-08 53.9 COG0048@1|root,COG0049@1|root,COG1007@1|root,KOG1750@2759|Eukaryota,KOG3291@2759|Eukaryota,KOG4668@2759|Eukaryota,37KVW@33090|Viridiplantae,3GH1R@35493|Streptophyta,4JNJF@91835|fabids 35493|Streptophyta C NAD(P)H-quinone oxidoreductase subunit 2 ndhB - 1.6.5.3 ko:K02992,ko:K05573 ko00190,ko01100,ko03010,map00190,map01100,map03010 M00145,M00178,M00179 R11945 RC00061 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - Proton_antipo_M k59_583244_1 326298.Suden_0090 3.84e-104 331.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2YMVS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C k59_909168_1 1168034.FH5T_05340 5.39e-101 301.0 COG1284@1|root,COG1284@2|Bacteria,4NG9F@976|Bacteroidetes,2FP2N@200643|Bacteroidia 976|Bacteroidetes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2179,YitT_membrane k59_942602_1 1168034.FH5T_20065 1.51e-98 296.0 COG1443@1|root,COG1443@2|Bacteria,4NJUP@976|Bacteroidetes,2FNMR@200643|Bacteroidia 976|Bacteroidetes I NUDIX domain - - - - - - - - - - - - IspA,NUDIX k59_92627_1 1391646.AVSU01000025_gene2518 1.04e-62 204.0 COG1984@1|root,COG1984@2|Bacteria,1TR6U@1239|Firmicutes,2485K@186801|Clostridia,25UAX@186804|Peptostreptococcaceae 186801|Clostridia E Allophanate hydrolase subunit 2 kipA - - ko:K06350 - - - - ko00000 - - - CT_A_B k59_876273_1 1042876.PPS_2488 4.12e-08 59.7 COG1511@1|root,COG5185@1|root,COG1511@2|Bacteria,COG5185@2|Bacteria,1QV8Y@1224|Proteobacteria,1T2AE@1236|Gammaproteobacteria 1236|Gammaproteobacteria D tail protein - - - - - - - - - - - - TMP_2,Tape_meas_lam_C k59_909176_1 768671.ThimaDRAFT_4705 1.14e-43 158.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales 135613|Chromatiales F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_713440_1 1265507.KB899636_gene1495 9.21e-11 65.1 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1Y4CE@135624|Aeromonadales 135624|Aeromonadales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_255651_1 406327.Mevan_1082 7.85e-33 117.0 COG0350@1|root,arCOG02724@2157|Archaea,2XZSR@28890|Euryarchaeota,23R8I@183939|Methanococci 183939|Methanococci J Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1 k59_255651_2 1172190.M947_04005 7.53e-43 150.0 COG1672@1|root,COG1672@2|Bacteria,1PMVJ@1224|Proteobacteria,42PCP@68525|delta/epsilon subdivisions,2YNZF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Archaea bacterial proteins of - - - ko:K06921 - - - - ko00000 - - - DUF234 k59_58008_1 246200.SPO3036 1.52e-105 324.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4ND2Q@97050|Ruegeria 28211|Alphaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_550954_1 326298.Suden_0133 7.76e-47 160.0 COG3637@1|root,COG3637@2|Bacteria,1R3QN@1224|Proteobacteria,42Y1W@68525|delta/epsilon subdivisions,2YQU0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_451867_2 1165841.SULAR_05853 6.88e-129 375.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2YMEQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G fructose-bisphosphate aldolase fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_387362_2 1131730.BAVI_22198 1.29e-21 86.7 COG1476@1|root,COG1476@2|Bacteria,1VEGF@1239|Firmicutes,4HNVM@91061|Bacilli,1ZJ56@1386|Bacillus 91061|Bacilli K Helix-turn-helix XRE-family like proteins lanR - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 k59_22164_1 746697.Aeqsu_2173 9.45e-85 256.0 COG0652@1|root,COG0652@2|Bacteria,4NMG5@976|Bacteroidetes,1I0CC@117743|Flavobacteriia 976|Bacteroidetes O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K01802,ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_1007738_2 2342.SOPEG_1249 5.83e-41 136.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_387370_1 1168034.FH5T_17085 1.56e-83 259.0 COG4591@1|root,COG4591@2|Bacteria,4NGJ3@976|Bacteroidetes,2FS1D@200643|Bacteroidia 976|Bacteroidetes M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_354745_1 563040.Saut_0259 6.81e-134 387.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,42MGE@68525|delta/epsilon subdivisions,2YNH0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_648764_1 1298593.TOL_3673 9.43e-07 56.2 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1XH3M@135619|Oceanospirillales 135619|Oceanospirillales H enzyme of heme biosynthesis hemX - 2.1.1.107 ko:K02496 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - HemX k59_319773_1 82654.Pse7367_3772 9.99e-20 87.8 2E4FZ@1|root,32ZB4@2|Bacteria,1GA00@1117|Cyanobacteria,1HD9D@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_255680_1 1229172.JQFA01000004_gene729 3.41e-24 100.0 2DMFF@1|root,32R5F@2|Bacteria,1GAQC@1117|Cyanobacteria 1117|Cyanobacteria S IMG reference gene - - - - - - - - - - - - - k59_648765_1 1165841.SULAR_06883 2.89e-74 247.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2YMGZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_807755_1 879212.DespoDRAFT_00220 6.31e-97 291.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2MMYC@213118|Desulfobacterales 28221|Deltaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_22180_1 1247726.MIM_c23680 2.46e-13 73.6 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2VHI3@28216|Betaproteobacteria,3T2K8@506|Alcaligenaceae 28216|Betaproteobacteria I Fatty acid fadL - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_354764_2 1239962.C943_00462 6.74e-71 228.0 COG1373@1|root,COG1373@2|Bacteria,4NE39@976|Bacteroidetes 976|Bacteroidetes S ATPase (AAA superfamily) - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_909211_1 387093.SUN_0143 6.55e-108 313.0 COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,42RXC@68525|delta/epsilon subdivisions,2YP4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S esterase of the alpha beta hydrolase fold - - - ko:K07002 - - - - ko00000 - - - Ser_hydrolase k59_125522_1 1463845.JOIG01000001_gene1626 5.51e-86 278.0 COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria 201174|Actinobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_744644_1 331869.BAL199_26771 3.23e-07 55.1 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRQD@28211|Alphaproteobacteria,4BQ27@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EGP Sugar (and other) transporter MA20_01870 - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_807767_1 1268240.ATFI01000013_gene1127 6.46e-129 385.0 COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,2FRKH@200643|Bacteroidia,4ARGS@815|Bacteroidaceae 976|Bacteroidetes S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 k59_681746_1 670487.Ocepr_1802 7.89e-19 91.3 COG3044@1|root,COG3044@2|Bacteria,1WJ90@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Predicted ATPase of the ABC class - - - - - - - - - - - - ABC_ATPase k59_326413_2 1408473.JHXO01000002_gene3790 3.77e-18 82.8 COG5297@1|root,COG5297@2|Bacteria,4NG19@976|Bacteroidetes,2FPX3@200643|Bacteroidia 976|Bacteroidetes G Protein of unknown function (DUF1593) - - - - - - - - - - - - DUF1593,DUF5060 k59_814971_1 1274524.BSONL12_00727 1.38e-08 56.2 COG4146@1|root,COG4146@2|Bacteria,1UHPR@1239|Firmicutes,4HDFI@91061|Bacilli,1ZDJB@1386|Bacillus 91061|Bacilli S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_326448_1 243090.RB2364 5.72e-12 67.0 COG0705@1|root,COG0705@2|Bacteria 2|Bacteria S proteolysis - - - - - - - - - - - - Rhomboid k59_326448_2 83406.HDN1F_12450 8.67e-53 168.0 COG2146@1|root,COG2146@2|Bacteria,1NNG5@1224|Proteobacteria,1SI49@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases ndoA - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske,Rieske_2 k59_326448_3 448385.sce4763 2.31e-73 243.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2X37C@28221|Deltaproteobacteria,2YUQZ@29|Myxococcales 28221|Deltaproteobacteria S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT k59_751552_1 395493.BegalDRAFT_3133 4.85e-116 346.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,460AE@72273|Thiotrichales 72273|Thiotrichales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_293667_1 323261.Noc_0241 2.49e-84 270.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_490280_1 203119.Cthe_0601 5.95e-89 275.0 COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,3WJ1D@541000|Ruminococcaceae 186801|Clostridia H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_490280_2 469616.FMAG_01693 1.43e-212 597.0 COG0422@1|root,COG0422@2|Bacteria,378PD@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM k59_293672_1 573061.Clocel_2482 2.05e-40 156.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae 186801|Clostridia Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_815025_1 765913.ThidrDRAFT_2858 5.38e-21 92.8 COG0457@1|root,COG0457@2|Bacteria,1N3T7@1224|Proteobacteria,1SFI0@1236|Gammaproteobacteria,1WY1U@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 k59_293692_1 1121396.KB893070_gene1325 8.05e-83 260.0 COG0614@1|root,COG0614@2|Bacteria,1Q4BV@1224|Proteobacteria,42TPS@68525|delta/epsilon subdivisions,2WQYM@28221|Deltaproteobacteria,2MNA4@213118|Desulfobacterales 28221|Deltaproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_293696_1 1168034.FH5T_10390 8.09e-74 236.0 COG1538@1|root,COG1538@2|Bacteria,4NGIX@976|Bacteroidetes,2FM9H@200643|Bacteroidia 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_293696_2 1168034.FH5T_10395 4.3e-13 68.6 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,2FQSG@200643|Bacteroidia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23,OEP k59_28692_1 999419.HMPREF1077_01984 5.13e-37 140.0 COG0642@1|root,COG2205@2|Bacteria,4NEFW@976|Bacteroidetes,2FPG5@200643|Bacteroidia,22WQ1@171551|Porphyromonadaceae 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_326507_1 360107.CHAB381_0374 1.85e-19 86.7 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2YNCB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0330 IlvC,IlvN k59_326507_2 1165841.SULAR_09204 4.94e-41 151.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,42RJN@68525|delta/epsilon subdivisions,2YP6V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Divergent polysaccharide deacetylase - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_490342_1 298655.KI912266_gene105 9.31e-07 50.1 COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4ERKI@85013|Frankiales 201174|Actinobacteria U type II secretion system protein E cpaF - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_490342_2 479431.Namu_1650 1.06e-46 160.0 COG4965@1|root,COG4965@2|Bacteria,2I3KW@201174|Actinobacteria,4EXBE@85013|Frankiales 201174|Actinobacteria U Type II secretion system - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_293713_1 641524.ADICYQ_5063 2.62e-08 55.5 2CFVU@1|root,3373K@2|Bacteria,4NY6U@976|Bacteroidetes,47VQB@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_751655_1 1291050.JAGE01000002_gene3867 1.6e-07 54.3 COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,3WGEC@541000|Ruminococcaceae 186801|Clostridia L HELICc2 dinG - 3.1.12.1,3.6.4.12 ko:K07464,ko:K10844 ko03022,ko03420,map03022,map03420 M00290 - - ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400 - - - DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1 k59_326559_1 886882.PPSC2_c0629 4.67e-32 121.0 COG0179@1|root,COG0179@2|Bacteria,1TXA5@1239|Firmicutes,4I67F@91061|Bacilli,26R3V@186822|Paenibacillaceae 91061|Bacilli Q Fumarylacetoacetate hydrolase mhpD - - - - - - - - - - - FAA_hydrolase k59_326559_2 1128398.Curi_c23030 1.15e-62 193.0 COG2824@1|root,COG2824@2|Bacteria,1V6NA@1239|Firmicutes,24J9K@186801|Clostridia,26BN3@186813|unclassified Clostridiales 186801|Clostridia P PhnA Zinc-Ribbon phnA - - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k59_815100_1 525897.Dbac_3425 5.2e-28 121.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WJYB@28221|Deltaproteobacteria,2MEI4@213115|Desulfovibrionales 28221|Deltaproteobacteria NU Neisseria PilC beta-propeller domain - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_293750_1 572544.Ilyop_R0032 7.09e-118 353.0 COG1292@1|root,COG1292@2|Bacteria,37AIW@32066|Fusobacteria 32066|Fusobacteria M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K02168 - - - - ko00000,ko02000 2.A.15.1.3,2.A.15.1.4 - - BCCT k59_28746_1 1120951.AUBG01000010_gene2079 2.34e-82 245.0 COG0720@1|root,COG0720@2|Bacteria,4NM8H@976|Bacteroidetes,1I173@117743|Flavobacteriia 976|Bacteroidetes H 6-pyruvoyl tetrahydropterin synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_293777_1 1167006.UWK_00315 2.41e-31 118.0 COG0676@1|root,COG0676@2|Bacteria,1Q7VN@1224|Proteobacteria,42SFK@68525|delta/epsilon subdivisions 1224|Proteobacteria G Belongs to the glucose-6-phosphate 1-epimerase family yeaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 5.1.3.15 ko:K01792 ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130 - R02739 RC00563 ko00000,ko00001,ko01000 - - - Aldose_epim k59_293777_2 388919.SSA_1558 3.98e-11 68.6 COG0561@1|root,COG0561@2|Bacteria,1TR2E@1239|Firmicutes,4HGA9@91061|Bacilli,1WRF1@1305|Streptococcus sanguinis 91061|Bacilli S overlaps another CDS with the same product name XK27_02985 - - - - - - - - - - - Hydrolase_3 k59_28780_1 1279019.ARQK01000049_gene41 1.67e-34 131.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_28780_2 318161.Sden_3218 2.83e-28 113.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,2Q8Z8@267890|Shewanellaceae 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_64644_1 247634.GPB2148_368 2.61e-124 367.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 ATP-synt_ab,ATP-synt_ab_N k59_293798_1 879212.DespoDRAFT_00037 2.33e-85 276.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2MIEG@213118|Desulfobacterales 28221|Deltaproteobacteria GT pyruvate phosphate dikinase - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_293804_1 886379.AEWI01000026_gene424 2.88e-86 277.0 COG0550@1|root,COG0550@2|Bacteria,4NF9S@976|Bacteroidetes,2FMSF@200643|Bacteroidia,3XINJ@558415|Marinilabiliaceae 976|Bacteroidetes L Bacterial DNA topoisomeraes I ATP-binding domain topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt k59_751784_1 1496688.ER33_14805 4.31e-96 295.0 COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,22TKK@167375|Cyanobium 1117|Cyanobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_293815_1 1511.CLOST_1327 2.3e-126 380.0 COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,25R24@186804|Peptostreptococcaceae 186801|Clostridia S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_293820_1 506534.Rhein_1314 1.37e-48 164.0 COG1876@1|root,COG1876@2|Bacteria,1N2IC@1224|Proteobacteria,1S0DU@1236|Gammaproteobacteria 1236|Gammaproteobacteria M D-alanyl-D-alanine carboxypeptidase vanY - - - - - - - - - - - VanY k59_64658_1 1480694.DC28_10430 4.9e-38 141.0 COG0475@1|root,COG0475@2|Bacteria,2J5WC@203691|Spirochaetes 203691|Spirochaetes P Sodium hydrogen exchanger family - - - - - - - - - - - - CBS,Na_H_Exchanger k59_64658_2 1480694.DC28_10425 1.12e-07 53.5 29AXJ@1|root,2ZXWN@2|Bacteria,2JBAS@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - k59_64658_3 526218.Sterm_2169 4.97e-208 586.0 COG2873@1|root,COG2873@2|Bacteria,379HR@32066|Fusobacteria 32066|Fusobacteria E Cys/Met metabolism PLP-dependent enzyme - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_64658_6 536227.CcarbDRAFT_3637 1.84e-83 265.0 COG2607@1|root,COG2607@2|Bacteria,1TQDJ@1239|Firmicutes,2483S@186801|Clostridia,36EJK@31979|Clostridiaceae 186801|Clostridia S ATPase (AAA superfamily) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_751818_1 29760.VIT_00s0246g00170.t01 6.14e-33 122.0 COG0755@1|root,2QU0T@2759|Eukaryota,37NBU@33090|Viridiplantae,3GH1G@35493|Streptophyta 35493|Streptophyta O Cytochrome c biogenesis protein CcsA ccsA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008150,GO:0008152,GO:0009536,GO:0015886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:1901678 - - - - - - - - - - Cytochrom_C_asm k59_64674_1 1322246.BN4_11567 1.25e-35 138.0 COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2M7VM@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_9 k59_28832_1 690850.Desaf_2591 1.15e-45 169.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2M97J@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_751844_1 177437.HRM2_39420 9.51e-43 157.0 COG0745@1|root,COG2202@1|root,COG4191@1|root,COG4936@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MPRS@213118|Desulfobacterales 28221|Deltaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_815219_2 1121447.JONL01000002_gene1773 4.75e-06 48.9 2EJAZ@1|root,33D23@2|Bacteria,1NGTE@1224|Proteobacteria,42WZV@68525|delta/epsilon subdivisions,2WSJH@28221|Deltaproteobacteria,2MDVR@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_64692_1 1385517.N800_06035 3.45e-64 216.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales 135614|Xanthomonadales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_64692_2 1517416.IDAT_11080 4.13e-31 117.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,2QFMS@267893|Idiomarinaceae 1236|Gammaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_28856_1 335543.Sfum_2392 8.25e-54 184.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42P7V@68525|delta/epsilon subdivisions,2WJQA@28221|Deltaproteobacteria,2MQ5A@213462|Syntrophobacterales 28221|Deltaproteobacteria V ABC-2 family transporter protein ybhS - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_751863_1 1454004.AW11_02394 2.68e-109 328.0 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria 28216|Betaproteobacteria S Phospholipase, patatin family - - - ko:K07001 - - - - ko00000 - - - Patatin k59_28862_1 1168034.FH5T_12295 1.55e-79 243.0 COG0647@1|root,COG0647@2|Bacteria,4NG49@976|Bacteroidetes,2FRNM@200643|Bacteroidia 976|Bacteroidetes G Haloacid dehalogenase-like hydrolase - - - ko:K02566 - - - - ko00000 - - - Hydrolase_6,Hydrolase_like k59_326758_1 1165841.SULAR_05628 4.21e-114 333.0 COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,42MBG@68525|delta/epsilon subdivisions,2YMHE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively pfs - 3.2.2.30,3.2.2.9 ko:K18284 ko00130,ko00270,ko01100,ko01110,ko01230,map00130,map00270,map01100,map01110,map01230 M00034,M00609 R00194,R01401,R10668 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_293935_1 944480.ATUV01000001_gene1728 9.07e-06 47.4 COG0296@1|root,COG0296@2|Bacteria,1RGK6@1224|Proteobacteria,42S24@68525|delta/epsilon subdivisions,2WNU4@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Glycogen recognition site of AMP-activated protein kinase - - - - - - - - - - - - AMPK1_CBM k59_293935_2 118005.AWNK01000003_gene2293 1.69e-26 104.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigM - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2,SnoaL_2 k59_815293_1 519989.ECTPHS_09707 1.12e-49 172.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales 135613|Chromatiales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_64765_1 1168034.FH5T_19015 1.99e-115 347.0 COG0644@1|root,COG0644@2|Bacteria,4P040@976|Bacteroidetes 976|Bacteroidetes C oxidoreductase - - - - - - - - - - - - - k59_64765_2 109871.XP_006675196.1 0.00024 43.1 COG0664@1|root,KOG1113@2759|Eukaryota,38GS1@33154|Opisthokonta,3NU9Z@4751|Fungi 4751|Fungi T cAMP-dependent protein kinase regulatory subunit PKAR GO:0000003,GO:0000228,GO:0000785,GO:0000790,GO:0001932,GO:0001933,GO:0002831,GO:0002832,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005886,GO:0006469,GO:0006950,GO:0006979,GO:0007154,GO:0008104,GO:0008150,GO:0008603,GO:0009266,GO:0009267,GO:0009405,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009653,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010563,GO:0010570,GO:0010605,GO:0010639,GO:0010646,GO:0010648,GO:0016020,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0019954,GO:0022603,GO:0023051,GO:0023057,GO:0030154,GO:0030234,GO:0030291,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0031279,GO:0031281,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031981,GO:0032101,GO:0032102,GO:0032104,GO:0032105,GO:0032107,GO:0032108,GO:0032268,GO:0032269,GO:0032502,GO:0033036,GO:0033043,GO:0033554,GO:0033673,GO:0034305,GO:0034599,GO:0034605,GO:0034613,GO:0036170,GO:0036180,GO:0040007,GO:0040008,GO:0042173,GO:0042221,GO:0042325,GO:0042326,GO:0042594,GO:0043085,GO:0043086,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043549,GO:0043934,GO:0043936,GO:0043937,GO:0043938,GO:0043943,GO:0043945,GO:0044092,GO:0044093,GO:0044182,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045595,GO:0045597,GO:0045761,GO:0045762,GO:0045859,GO:0045881,GO:0045926,GO:0045936,GO:0046578,GO:0046580,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051056,GO:0051058,GO:0051094,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051246,GO:0051248,GO:0051338,GO:0051339,GO:0051348,GO:0051349,GO:0051641,GO:0051704,GO:0051716,GO:0051783,GO:0051784,GO:0060255,GO:0060258,GO:0065007,GO:0065009,GO:0070013,GO:0070727,GO:0070887,GO:0071496,GO:0071900,GO:0071901,GO:0071944,GO:0080090,GO:0080134,GO:0097271,GO:0098772,GO:1900428,GO:1900429,GO:1900434,GO:1900435,GO:1900443,GO:1900444,GO:1902531,GO:1902532,GO:1903664,GO:1903666 - ko:K04739 ko04910,map04910 - - - ko00000,ko00001 - - - RIIa,cNMP_binding k59_815300_2 365044.Pnap_0134 6.94e-05 44.7 COG2445@1|root,COG2445@2|Bacteria,1RD67@1224|Proteobacteria,2VRFC@28216|Betaproteobacteria,4AE09@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function DUF86 - - - - - - - - - - - - DUF86 k59_815300_3 1114970.PSF113_5642 6.9e-09 56.2 COG1669@1|root,COG1669@2|Bacteria,1RH50@1224|Proteobacteria,1SBXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DNA polymerase - - - - - - - - - - - - NTP_transf_2 k59_326771_1 1122179.KB890469_gene601 7e-89 276.0 COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes 976|Bacteroidetes P Arylsulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_326807_1 1167006.UWK_01948 1.48e-74 240.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2WKSV@28221|Deltaproteobacteria,2MHUQ@213118|Desulfobacterales 28221|Deltaproteobacteria P Na H antiporter - - - - - - - - - - - - CitMHS,PAS k59_815343_1 1187851.A33M_3284 1.04e-36 140.0 COG0655@1|root,COG0655@2|Bacteria 2|Bacteria S NAD(P)H dehydrogenase (quinone) activity - - - - - - - - - - - - FMN_red k59_64813_1 929558.SMGD1_1600 9.58e-46 159.0 2A54K@1|root,30TT8@2|Bacteria,1Q98H@1224|Proteobacteria,4348V@68525|delta/epsilon subdivisions,2YRCN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_64813_2 626887.J057_23810 4.44e-53 174.0 2DC7W@1|root,2ZD7C@2|Bacteria,1QU8S@1224|Proteobacteria,1S6MA@1236|Gammaproteobacteria,46BPC@72275|Alteromonadaceae 1236|Gammaproteobacteria S Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_65825_1 996637.SGM_2861 1.07e-21 99.0 COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria 201174|Actinobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_719654_1 1123228.AUIH01000001_gene1377 2.51e-09 64.3 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria,1XIKZ@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_65827_1 177437.HRM2_28140 2.01e-68 216.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2WJJW@28221|Deltaproteobacteria,2MI7B@213118|Desulfobacterales 28221|Deltaproteobacteria J PFAM glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_2942 tRNA-synt_2e k59_883111_1 761193.Runsl_2102 4.12e-10 60.1 arCOG14808@1|root,308PC@2|Bacteria,4NR4D@976|Bacteroidetes,47PEP@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 k59_915779_1 933262.AXAM01000055_gene1260 2.46e-13 68.9 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,2MHTS@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1,NUDIX k59_915779_2 933262.AXAM01000055_gene1259 4.64e-51 172.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2MIV2@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_883117_1 765914.ThisiDRAFT_2309 9.9e-93 289.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales 135613|Chromatiales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_98559_2 713586.KB900536_gene42 1.28e-55 189.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1TK7U@1236|Gammaproteobacteria,1X089@135613|Chromatiales 135613|Chromatiales L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8 k59_262011_2 1500897.JQNA01000002_gene998 1.59e-38 141.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1JZM8@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the DEAD box helicase family rhlE2 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_948427_2 1349767.GJA_3422 8.62e-20 90.5 COG4675@1|root,COG4675@2|Bacteria,1PGUT@1224|Proteobacteria,2VX8H@28216|Betaproteobacteria,4788V@75682|Oxalobacteraceae 28216|Betaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_392801_1 709032.Sulku_0488 2.94e-81 261.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2YMKH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_294700_2 1410670.JHXF01000016_gene2207 2.62e-52 175.0 COG1052@1|root,COG1052@2|Bacteria,1TSZ6@1239|Firmicutes,249PP@186801|Clostridia,3WGCU@541000|Ruminococcaceae 186801|Clostridia CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family ldhA - 1.1.1.28 ko:K03778 ko00620,ko01120,map00620,map01120 - R00704 RC00044 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C,PTS-HPr k59_494638_3 572544.Ilyop_0863 0.0 999.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,378G8@32066|Fusobacteria 32066|Fusobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,HHH_5 k59_494638_4 469616.FMAG_00834 6.11e-90 274.0 COG1481@1|root,COG1481@2|Bacteria,378E3@32066|Fusobacteria 32066|Fusobacteria K May be required for sporulation - - - ko:K09762 - - - - ko00000 - - - HTH_WhiA,LAGLIDADG_WhiA,WhiA_N k59_919822_1 1071073.KI530537_gene1645 9.42e-15 70.9 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,1ZD5J@1386|Bacillus 91061|Bacilli NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02243,ko:K02652 - M00429 - - ko00000,ko00002,ko02035,ko02044 3.A.14.1,3.A.15.2 - - T2SSE,T2SSE_N k59_919822_2 526218.Sterm_1185 2.11e-74 228.0 COG0503@1|root,COG0503@2|Bacteria,379FE@32066|Fusobacteria 32066|Fusobacteria F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_919822_3 572544.Ilyop_0687 0.0 1004.0 COG0317@1|root,COG0317@2|Bacteria,378FY@32066|Fusobacteria 32066|Fusobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_952079_1 926561.KB900617_gene2059 9.9e-10 64.3 COG3562@1|root,COG3562@2|Bacteria,1VAY8@1239|Firmicutes 1239|Firmicutes M Capsule polysaccharide biosynthesis protein - - - - - - - - - - - - Capsule_synth k59_2808_1 1537917.JU82_03400 2.56e-74 249.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42Z31@68525|delta/epsilon subdivisions,2YRAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Hpt sensor hybrid histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_560191_1 1123075.AUDP01000027_gene681 1.46e-146 422.0 COG0673@1|root,COG0673@2|Bacteria,1TRHA@1239|Firmicutes,24FFY@186801|Clostridia 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_135251_1 2340.JV46_06870 1.1e-47 161.0 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1S11C@1236|Gammaproteobacteria,1JBER@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_135251_2 670487.Ocepr_0948 6.26e-16 81.3 COG0058@1|root,COG0058@2|Bacteria,1WIR5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Alpha-glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_200042_1 583355.Caka_0487 2.77e-15 78.2 COG0811@1|root,COG0811@2|Bacteria,46SY0@74201|Verrucomicrobia,3K8FG@414999|Opitutae 74201|Verrucomicrobia U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_200042_3 1216362.B437_02821 4.36e-24 112.0 COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,3799H@32066|Fusobacteria 32066|Fusobacteria NU Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 k59_984599_1 709032.Sulku_2478 2.06e-77 241.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2YN2D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_36409_1 387093.SUN_0831 2.21e-67 212.0 COG0596@1|root,COG0596@2|Bacteria,1NH3R@1224|Proteobacteria,42R8Q@68525|delta/epsilon subdivisions,2YNWT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_788554_1 1216966.BAUC01000019_gene892 1.92e-07 55.1 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_788554_2 998088.B565_3400 1.16e-18 85.1 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1Y430@135624|Aeromonadales 135624|Aeromonadales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_168076_1 1449351.RISW2_02495 4.72e-183 513.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,4KMUV@93682|Roseivivax 28211|Alphaproteobacteria L transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1017385_1 1168034.FH5T_07830 1.9e-79 269.0 COG1196@1|root,COG1196@2|Bacteria,4NF7P@976|Bacteroidetes,2FXCC@200643|Bacteroidia 976|Bacteroidetes D nuclear chromosome segregation - - - - - - - - - - - - DUF4175 k59_69376_1 435590.BVU_1335 3.29e-112 348.0 COG0550@1|root,COG0550@2|Bacteria,4NF9S@976|Bacteroidetes,2FMSF@200643|Bacteroidia,4AKH7@815|Bacteroidaceae 976|Bacteroidetes L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt k59_560203_1 1244869.H261_17408 1.36e-71 228.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria,2JQIC@204441|Rhodospirillales 204441|Rhodospirillales C NiFe/NiFeSe hydrogenase small subunit C-terminal - - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_102523_1 1396858.Q666_15830 9.27e-49 161.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,46779@72275|Alteromonadaceae 1236|Gammaproteobacteria S metal-binding protein copG - - - - - - - - - - - DUF411 k59_233032_1 929558.SMGD1_2447 5.7e-110 343.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2YMQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_233032_2 1537917.JU82_07845 2.08e-52 186.0 COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2YMXW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cytochrome c biogenesis protein ccsBA - - - - - - - - - - - Cytochrom_C_asm,ResB k59_135266_1 640512.BC1003_5716 2.48e-28 110.0 COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2VUP1@28216|Betaproteobacteria,1K02M@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the Fur family zur - - ko:K09823 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - FUR k59_428696_2 1168034.FH5T_20650 9.32e-98 289.0 COG1595@1|root,COG1595@2|Bacteria,4NMAK@976|Bacteroidetes,2G2W5@200643|Bacteroidia 976|Bacteroidetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_592093_1 306263.Cla_0647 3.76e-60 189.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,42MQB@68525|delta/epsilon subdivisions,2YM8X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_592093_2 326298.Suden_1262 8.13e-14 66.2 2BR7U@1|root,32K64@2|Bacteria,1Q2P2@1224|Proteobacteria,431JX@68525|delta/epsilon subdivisions,2YSDV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_1017408_1 1165841.SULAR_08582 3.98e-61 202.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,42P57@68525|delta/epsilon subdivisions,2YMGG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_135758_1 1168034.FH5T_05190 1.52e-25 101.0 COG4152@1|root,COG4152@2|Bacteria,4NEJE@976|Bacteroidetes,2FMK3@200643|Bacteroidia 976|Bacteroidetes S ABC transporter, ATP-binding protein natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_135758_2 398720.MED217_09310 3.24e-104 312.0 COG3507@1|root,COG3507@2|Bacteria,4NJHA@976|Bacteroidetes,1I802@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_32N k59_69797_1 1163617.SCD_n01038 5.39e-83 253.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2VJRD@28216|Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_1017850_1 1168034.FH5T_12140 2.86e-125 369.0 COG0168@1|root,COG0168@2|Bacteria,4NGMF@976|Bacteroidetes,2FNQZ@200643|Bacteroidia 976|Bacteroidetes P potassium uptake protein, TrkH family trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_135762_1 1168034.FH5T_05785 6.17e-18 81.6 COG0248@1|root,COG0248@2|Bacteria,4NEI0@976|Bacteroidetes,2FN6C@200643|Bacteroidia 976|Bacteroidetes FP Ppx GppA phosphatase family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_135762_2 1121904.ARBP01000013_gene349 3.95e-117 346.0 COG4948@1|root,COG4948@2|Bacteria,4NKNN@976|Bacteroidetes,47JKW@768503|Cytophagia 976|Bacteroidetes M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_429048_1 999419.HMPREF1077_01612 2.21e-81 265.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,2FMFA@200643|Bacteroidia,22WUH@171551|Porphyromonadaceae 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_723571_1 1353537.TP2_05900 2.17e-68 211.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2TV3J@28211|Alphaproteobacteria,2XMJ7@285107|Thioclava 28211|Alphaproteobacteria J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE k59_527974_1 1235798.C817_05173 4.45e-33 127.0 COG1502@1|root,COG1502@2|Bacteria,1TRJE@1239|Firmicutes,248ZE@186801|Clostridia,27WDZ@189330|Dorea 186801|Clostridia I ORF6N domain - - - - - - - - - - - - ORF6N k59_920315_1 1121943.KB900012_gene4060 1.98e-95 286.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RR8F@1236|Gammaproteobacteria,1XRIQ@135619|Oceanospirillales 135619|Oceanospirillales L Integrase core domain - - - - - - - - - - - - HTH_21,rve_3 k59_200512_2 1250278.JQNQ01000001_gene1444 3.78e-14 68.9 COG0590@1|root,COG0590@2|Bacteria,4NNMU@976|Bacteroidetes,1I1ZI@117743|Flavobacteriia 976|Bacteroidetes FJ deaminase guaD - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - MafB19-deam,dCMP_cyt_deam_1 k59_3100_1 765914.ThisiDRAFT_2130 8.54e-87 265.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1WWU0@135613|Chromatiales 135613|Chromatiales F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_690978_1 1121422.AUMW01000016_gene2094 6.29e-29 110.0 COG5433@1|root,COG5433@2|Bacteria,1V3B8@1239|Firmicutes 1239|Firmicutes L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_658808_1 563040.Saut_1579 2.88e-77 247.0 COG1807@1|root,COG1807@2|Bacteria,1Q901@1224|Proteobacteria,42MGX@68525|delta/epsilon subdivisions,2YNER@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M integral membrane protein - - - - - - - - - - - - PMT_2 k59_854493_1 904144.AEJD01000010_gene1088 1.51e-29 107.0 2B47U@1|root,31WZ2@2|Bacteria,2IPAW@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_265650_1 387093.SUN_1787 9.75e-42 144.0 COG0476@1|root,COG0476@2|Bacteria,1P1FY@1224|Proteobacteria,42PK6@68525|delta/epsilon subdivisions,2YNCI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H involved in molybdopterin and thiamine biosynthesis family 2 - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_265650_2 387093.SUN_1786 5.15e-29 105.0 2B3E9@1|root,31W34@2|Bacteria,1MZ95@1224|Proteobacteria,42U85@68525|delta/epsilon subdivisions,2YQ41@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_886567_1 1044.EH31_01830 4.55e-61 201.0 COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria,2K4IM@204457|Sphingomonadales 204457|Sphingomonadales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_560688_1 765914.ThisiDRAFT_0772 2.22e-23 100.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1X102@135613|Chromatiales 135613|Chromatiales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_462796_1 702450.CUW_1895 5.77e-37 139.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,3VNW2@526524|Erysipelotrichia 526524|Erysipelotrichia V ABC transporter, ATP-binding protein - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_233500_1 709032.Sulku_0724 1.13e-153 447.0 COG3608@1|root,COG3608@2|Bacteria,1Q5G3@1224|Proteobacteria,42MSH@68525|delta/epsilon subdivisions,2YMTA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S C-terminal domain of metallo-carboxypeptidase - - - - - - - - - - - - Peptidase_M99,Peptidase_M99_C k59_233500_2 326298.Suden_1379 5.77e-86 266.0 COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,42QS4@68525|delta/epsilon subdivisions,2YNYQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ErfK YbiS YcfS YnhG family protein pgp2 - - - - - - - - - - - YkuD k59_952475_2 572544.Ilyop_0931 3.76e-108 323.0 COG0582@1|root,COG0582@2|Bacteria,379QR@32066|Fusobacteria 32066|Fusobacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_265659_1 883.DvMF_1772 5.9e-34 120.0 COG2204@1|root,COG2204@2|Bacteria,1QUMA@1224|Proteobacteria,43BKZ@68525|delta/epsilon subdivisions,2X6Z5@28221|Deltaproteobacteria,2MH8W@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_265659_2 289376.THEYE_A0734 6.4e-32 116.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - Response_reg k59_723595_1 1165841.SULAR_07570 7.74e-74 227.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42RES@68525|delta/epsilon subdivisions,2YP9Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_920335_1 933262.AXAM01000106_gene2631 8.91e-43 152.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales 28221|Deltaproteobacteria S Paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA k59_920335_2 525897.Dbac_0330 8.92e-13 67.0 COG2995@1|root,COG2995@2|Bacteria,1RAQ9@1224|Proteobacteria,42TYA@68525|delta/epsilon subdivisions,2WQ76@28221|Deltaproteobacteria,2MF5E@213115|Desulfovibrionales 28221|Deltaproteobacteria S Paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA k59_135796_1 1403313.AXBR01000014_gene2199 2.77e-08 53.1 2DR8Z@1|root,33AQV@2|Bacteria,1VK7N@1239|Firmicutes,4IDP9@91061|Bacilli,1ZNDA@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_789010_1 1121015.N789_00770 1.32e-35 140.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1X4R3@135614|Xanthomonadales 135614|Xanthomonadales E homoserine dehydrogenase thrA - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_364195_1 926549.KI421517_gene3646 6.13e-14 79.0 COG1629@1|root,COG3078@1|root,COG3078@2|Bacteria,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,47TT5@768503|Cytophagia 976|Bacteroidetes P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_396908_1 1268240.ATFI01000013_gene1127 2.12e-52 182.0 COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,2FRKH@200643|Bacteroidia,4ARGS@815|Bacteroidaceae 976|Bacteroidetes S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 k59_233510_1 1266914.ATUK01000004_gene1696 2.63e-130 396.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales 135613|Chromatiales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_298431_1 768671.ThimaDRAFT_4015 1.31e-89 278.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1WWGN@135613|Chromatiales 135613|Chromatiales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_103059_1 1168034.FH5T_21720 1.2e-75 240.0 2C95T@1|root,2Z7NG@2|Bacteria,4NGVW@976|Bacteroidetes,2G2HY@200643|Bacteroidia 976|Bacteroidetes S Capsule assembly protein Wzi - - - - - - - - - - - - Caps_assemb_Wzi k59_36846_1 335543.Sfum_2640 1.55e-13 69.7 29QS6@1|root,30BS1@2|Bacteria,1REGY@1224|Proteobacteria,42RJ2@68525|delta/epsilon subdivisions,2WNQQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_985087_1 886379.AEWI01000058_gene2577 3.05e-18 81.3 COG5433@1|root,COG5433@2|Bacteria,4P5P2@976|Bacteroidetes 976|Bacteroidetes L transposase activity - - - - - - - - - - - - - k59_396920_1 1144275.COCOR_00925 3.97e-61 209.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales 28221|Deltaproteobacteria P copper-translocating P-type ATPase copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_789025_3 1049564.TevJSym_bf00160 0.000285 43.1 28P01@1|root,338A2@2|Bacteria,1NBSK@1224|Proteobacteria,1SS2R@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_495181_2 96561.Dole_1590 1.19e-34 127.0 COG0778@1|root,COG1146@1|root,COG0778@2|Bacteria,COG1146@2|Bacteria,1NCVT@1224|Proteobacteria,42Y7G@68525|delta/epsilon subdivisions,2WUEJ@28221|Deltaproteobacteria,2MMPD@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Nitroreductase k59_1017907_1 1380600.AUYN01000006_gene418 4.42e-31 124.0 COG1418@1|root,COG1418@2|Bacteria,4NFAG@976|Bacteroidetes,1HWWN@117743|Flavobacteriia 976|Bacteroidetes S Phosphohydrolase - - - - - - - - - - - - HD k59_952476_1 526218.Sterm_1907 2.23e-26 107.0 COG4992@1|root,COG4992@2|Bacteria,37CU4@32066|Fusobacteria 32066|Fusobacteria E K00821 acetylornithine N-succinyldiaminopimelate aminotransferase argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_952476_2 526218.Sterm_1908 2.39e-165 470.0 COG0078@1|root,COG0078@2|Bacteria,379G1@32066|Fusobacteria 32066|Fusobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_952476_3 572544.Ilyop_0047 1.46e-102 304.0 COG0101@1|root,COG0101@2|Bacteria,3784K@32066|Fusobacteria 32066|Fusobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_952476_4 572544.Ilyop_0046 2.16e-40 139.0 COG0454@1|root,COG0456@2|Bacteria,37AF8@32066|Fusobacteria 32066|Fusobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_952476_5 880073.Calab_1910 1.92e-29 127.0 COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,2NPIU@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,Response_reg k59_69854_2 765912.Thimo_2390 8.6e-28 110.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1WWWJ@135613|Chromatiales 135613|Chromatiales O HflC and HflK could encode or regulate a protease - - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_691022_1 1168034.FH5T_05305 1.4e-144 425.0 COG0142@1|root,COG1852@1|root,COG0142@2|Bacteria,COG1852@2|Bacteria 2|Bacteria S Protein of unknown function DUF116 ispB - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K02523,ko:K09729,ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - DUF116,polyprenyl_synt k59_691022_2 1168034.FH5T_05300 1.25e-53 179.0 COG0535@1|root,COG0535@2|Bacteria,4NQ4R@976|Bacteroidetes,2FT2F@200643|Bacteroidia 976|Bacteroidetes C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_1017908_1 1165841.SULAR_05543 6.05e-92 288.0 COG0642@1|root,COG4564@1|root,COG0642@2|Bacteria,COG4564@2|Bacteria,1QZ2C@1224|Proteobacteria,42QBR@68525|delta/epsilon subdivisions,2YNQB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,dCache_2,sCache_2 k59_1017908_2 387093.SUN_1144 4.25e-93 278.0 COG0745@1|root,COG0745@2|Bacteria,1Q5DC@1224|Proteobacteria,42R42@68525|delta/epsilon subdivisions,2YNXG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_368874_2 477974.Daud_1033 4.81e-98 306.0 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2613E@186807|Peptococcaceae 186801|Clostridia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_891040_1 1122135.KB893171_gene2110 2.03e-09 59.3 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Phosphate - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_891040_2 744980.TRICHSKD4_5548 1.18e-09 58.5 COG0494@1|root,COG0494@2|Bacteria,1MZ5D@1224|Proteobacteria,2UBX9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_858304_1 1005058.UMN179_00576 1.49e-17 87.4 COG0457@1|root,COG0457@2|Bacteria,1P464@1224|Proteobacteria,1T2SW@1236|Gammaproteobacteria,1Y86B@135625|Pasteurellales 135625|Pasteurellales S Protein of unknown function (DUF560) - - - - - - - - - - - - DUF560 k59_269541_1 1165841.SULAR_02743 8.18e-53 180.0 COG0479@1|root,COG0479@2|Bacteria,1QE4T@1224|Proteobacteria,42QE6@68525|delta/epsilon subdivisions,2YM7P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit - - - - - - - - - - - - - k59_956312_1 1035197.HMPREF9999_00614 1.88e-42 160.0 COG2605@1|root,COG2605@2|Bacteria,4NHF2@976|Bacteroidetes,2FMWG@200643|Bacteroidia,1WCWV@1283313|Alloprevotella 976|Bacteroidetes S L-fucokinase fkp - - - - - - - - - - - Fucokinase,GHMP_kinases_C,GHMP_kinases_N k59_269545_1 933262.AXAM01000098_gene3456 3.5e-57 187.0 COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,42MYE@68525|delta/epsilon subdivisions,2WJC7@28221|Deltaproteobacteria,2MIWS@213118|Desulfobacterales 28221|Deltaproteobacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_368884_1 96561.Dole_1783 5.51e-33 119.0 COG1848@1|root,COG1848@2|Bacteria,1QW1E@1224|Proteobacteria,42XA6@68525|delta/epsilon subdivisions,2X728@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_368884_2 1415780.JPOG01000001_gene722 3.07e-07 50.4 COG4118@1|root,COG4118@2|Bacteria 2|Bacteria D positive regulation of growth - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - PhdYeFM_antitox k59_107658_1 481448.Minf_1849 2.11e-10 62.8 2EG21@1|root,339U1@2|Bacteria,46ZFR@74201|Verrucomicrobia,37GZS@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Protein required for attachment to host cells - - - - - - - - - - - - Host_attach k59_107658_2 572480.Arnit_2222 9.32e-27 102.0 2AJSI@1|root,31AEV@2|Bacteria,1Q5GJ@1224|Proteobacteria,4317Q@68525|delta/epsilon subdivisions,2YS8K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_107658_3 1321778.HMPREF1982_02221 1.16e-15 76.3 COG2905@1|root,COG2905@2|Bacteria,1VW3X@1239|Firmicutes,24MYP@186801|Clostridia 186801|Clostridia T Cbs domain - - - - - - - - - - - - CBS k59_891054_1 1249480.B649_00895 6.94e-117 343.0 COG3943@1|root,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,42NYC@68525|delta/epsilon subdivisions,2YN8N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Virulence protein RhuM family - - - - - - - - - - - - Virulence_RhuM k59_858320_1 251221.35212378 1.48e-09 65.1 COG1566@1|root,COG1566@2|Bacteria 2|Bacteria V PFAM secretion protein HlyD family protein - - - - - - - - - - - - DUF3667,HlyD_3 k59_597432_1 545697.HMPREF0216_03432 7.21e-17 79.7 COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,36DFV@31979|Clostridiaceae 186801|Clostridia C Oxidoreductase pyrK_1 - 1.18.1.2,1.19.1.1 ko:K00528,ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146,R10159 RC00065 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_956324_2 502025.Hoch_4801 2.22e-33 127.0 COG3279@1|root,COG3279@2|Bacteria,1MVJI@1224|Proteobacteria,43ADC@68525|delta/epsilon subdivisions,2X5T8@28221|Deltaproteobacteria,2Z38R@29|Myxococcales 28221|Deltaproteobacteria K LytTr DNA-binding domain lytT - - ko:K02477,ko:K07705 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_302329_1 387093.SUN_0472 1.79e-13 73.9 COG3147@1|root,COG3147@2|Bacteria 2|Bacteria S peptidoglycan binding - - 2.7.7.7 ko:K02343,ko:K03642,ko:K03749 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - SPOR,TrbI k59_565047_1 983545.Glaag_0767 6.08e-78 242.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,469H9@72275|Alteromonadaceae 1236|Gammaproteobacteria M Mechanosensitive ion channel mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_40382_1 387093.SUN_0537 1.81e-80 263.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2YN0Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_140559_1 1249627.D779_1673 9.75e-74 231.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1WXSE@135613|Chromatiales 135613|Chromatiales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_532659_2 1122211.JMLW01000007_gene85 1.41e-101 305.0 COG2253@1|root,COG2253@2|Bacteria,1R3R3@1224|Proteobacteria,1S0PT@1236|Gammaproteobacteria,1XHH4@135619|Oceanospirillales 135619|Oceanospirillales S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_532659_3 589865.DaAHT2_1798 9.8e-55 181.0 COG5340@1|root,COG5340@2|Bacteria,1RGNP@1224|Proteobacteria,42UD1@68525|delta/epsilon subdivisions,2WQPR@28221|Deltaproteobacteria,2MM9V@213118|Desulfobacterales 28221|Deltaproteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_140563_1 1123367.C666_04415 8.56e-07 55.5 COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,2WGR6@28216|Betaproteobacteria 28216|Betaproteobacteria S E3 Ubiquitin ligase - - - - - - - - - - - - GIDE k59_1022242_1 1158345.JNLL01000001_gene2003 3.21e-122 352.0 COG0450@1|root,COG0450@2|Bacteria,2G4V9@200783|Aquificae 200783|Aquificae O C-terminal domain of 1-Cys peroxiredoxin - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_956334_1 1168034.FH5T_12260 1.05e-134 404.0 COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,2FM7F@200643|Bacteroidia 976|Bacteroidetes C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_695239_1 709032.Sulku_1390 1.1e-83 258.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2YMIC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_727537_1 1249627.D779_0654 4.46e-24 104.0 COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria,1WWP5@135613|Chromatiales 135613|Chromatiales M TIGRFAM TonB - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_727537_4 1198232.CYCME_0933 1.87e-31 113.0 COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,1SCWV@1236|Gammaproteobacteria,4615C@72273|Thiotrichales 72273|Thiotrichales N FlhB HrpN YscU SpaS Family - - - ko:K04061 - - - - ko00000,ko02044 - - - Bac_export_2 k59_727537_6 1158165.KB898876_gene1460 4.91e-26 112.0 COG1357@1|root,COG1357@2|Bacteria,1N15C@1224|Proteobacteria,1S9A9@1236|Gammaproteobacteria,1X1IB@135613|Chromatiales 135613|Chromatiales S Pentapeptide repeats (8 copies) - - - - - - - - - - - - Pentapeptide k59_727537_7 857087.Metme_2909 5.17e-65 205.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1XF04@135618|Methylococcales 135618|Methylococcales S pfam ammecr1 - - - - - - - - - - - - AMMECR1 k59_727537_8 572477.Alvin_0757 1.89e-92 280.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1WX63@135613|Chromatiales 135613|Chromatiales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_727537_9 1049564.TevJSym_ae00460 9.97e-192 540.0 COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria 1224|Proteobacteria C radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_727537_10 1163617.SCD_n00916 5.36e-29 114.0 COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,2VRC6@28216|Betaproteobacteria 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamE - - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA k59_727537_11 1049564.TevJSym_ac01260 8.23e-65 201.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,1J6EA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_727537_12 572477.Alvin_1382 1.24e-176 517.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales 135613|Chromatiales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_727537_13 1049564.TevJSym_ac01240 4.62e-101 304.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1J51G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iEcSMS35_1347.EcSMS35_2767 NAD_kinase k59_727537_14 765911.Thivi_4595 6.81e-132 388.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_727537_15 765911.Thivi_4596 5.1e-60 194.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales 135613|Chromatiales O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_727537_16 1049564.TevJSym_ac01200 0.0 1020.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1J4HD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_727537_17 1049564.TevJSym_ac01190 2.24e-199 561.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0006457,GO:0008150,GO:0009987 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_727537_18 1249627.D779_2923 2.39e-138 397.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_727537_19 1168065.DOK_08229 3.78e-14 81.6 COG3144@1|root,COG3144@2|Bacteria,1N7XT@1224|Proteobacteria,1SCA6@1236|Gammaproteobacteria,1J6YG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar hook-length control protein fliK GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook k59_727537_20 187272.Mlg_0933 2.57e-11 62.0 COG5416@1|root,COG5416@2|Bacteria,1QGGK@1224|Proteobacteria,1TDW9@1236|Gammaproteobacteria,1X1XZ@135613|Chromatiales 135613|Chromatiales S Pfam:DUF1049 - - - ko:K08992 - - - - ko00000 - - - LapA_dom k59_727537_21 1049564.TevJSym_ac01150 2.4e-105 322.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1J51N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509 - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_19,TPR_7,TPR_8 k59_727537_22 765913.ThidrDRAFT_4079 3.67e-100 299.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1WW0C@135613|Chromatiales 135613|Chromatiales F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_727537_23 794846.AJQU01000087_gene4768 2.29e-17 79.7 2E9ZT@1|root,33457@2|Bacteria,1N7P1@1224|Proteobacteria,2UF38@28211|Alphaproteobacteria,4BE80@82115|Rhizobiaceae 28211|Alphaproteobacteria S BA14K-like protein - - - - - - - - - - - - BA14K k59_727537_24 1279019.ARQK01000018_gene2548 5.05e-73 223.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1WX50@135613|Chromatiales 135613|Chromatiales O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_727537_25 1049564.TevJSym_ac01310 5.96e-245 684.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1J5IR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_727537_26 1049564.TevJSym_ac01300 4.1e-60 189.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1J6IB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG2867 Oligoketide cyclase lipid transport protein ratA GO:0003674,GO:0005488,GO:0006417,GO:0006446,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044877,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 - - - - - - - - - - Polyketide_cyc k59_727537_27 472759.Nhal_0884 1.09e-21 88.6 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,1WZ6P@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0125 (RnfH) family - - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_727537_28 314345.SPV1_07606 1.78e-183 516.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria 1224|Proteobacteria GM Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides rmlB2 - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_727537_29 1266914.ATUK01000017_gene549 1.36e-195 547.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1WWHP@135613|Chromatiales 135613|Chromatiales M PFAM NAD-dependent epimerase dehydratase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_727537_30 1249627.D779_0261 1.18e-74 224.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales 135613|Chromatiales S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_956338_1 555779.Dthio_PD3771 2.26e-84 279.0 COG1002@1|root,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,42PSP@68525|delta/epsilon subdivisions,2WQ97@28221|Deltaproteobacteria,2MD74@213115|Desulfovibrionales 28221|Deltaproteobacteria V Type II restriction enzyme, methylase subunits - - - - - - - - - - - - N6_Mtase k59_858336_1 1165841.SULAR_03737 1.05e-33 126.0 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,42QTP@68525|delta/epsilon subdivisions,2YPVD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_858336_2 1165841.SULAR_03742 4.47e-83 275.0 COG3387@1|root,COG3387@2|Bacteria,1MXWR@1224|Proteobacteria 1224|Proteobacteria G phosphorylase kinase alphabeta ygeQ - - ko:K07190 ko04020,ko04910,ko04922,map04020,map04910,map04922 - - - ko00000,ko00001 - - - Glyco_hydro_15 k59_695242_1 306281.AJLK01000081_gene1683 3.03e-20 95.9 COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae 1117|Cyanobacteria Q Ketoacyl-synthetase C-terminal extension - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt k59_140576_1 1249627.D779_1297 7.38e-127 376.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria,1WXQW@135613|Chromatiales 135613|Chromatiales C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - POR_N,TPP_enzyme_C k59_597467_1 1177154.Y5S_02202 4.5e-11 61.2 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1XH6R@135619|Oceanospirillales 135619|Oceanospirillales EH with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_597467_2 1232410.KI421415_gene3080 1.44e-60 201.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43T7B@69541|Desulfuromonadales 28221|Deltaproteobacteria EH Anthranilate synthase component I, N terminal region trpE - 4.1.3.27 ko:K01657,ko:K13503 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_891095_1 572477.Alvin_0467 1.53e-59 207.0 COG0587@1|root,COG1372@1|root,COG0587@2|Bacteria,COG1372@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_532681_1 1121405.dsmv_1915 6.66e-62 210.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MIU8@213118|Desulfobacterales 28221|Deltaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_74790_1 1408439.JHXW01000015_gene1730 2.01e-63 197.0 COG0698@1|root,COG0698@2|Bacteria,37AD6@32066|Fusobacteria 32066|Fusobacteria G Psort location Cytoplasmic, score 8.96 rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_74790_2 469616.FMAG_00910 1.76e-53 170.0 COG0537@1|root,COG0537@2|Bacteria,37ACH@32066|Fusobacteria 32066|Fusobacteria FG Histidine triad domain protein - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_597477_1 1134474.O59_003232 1.5e-48 172.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1FGZ5@10|Cellvibrio 1236|Gammaproteobacteria E Putative amidoligase enzyme (DUF2126) IV02_11925 - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_269591_1 933262.AXAM01000058_gene3196 5.53e-63 218.0 COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MICZ@213118|Desulfobacterales 28221|Deltaproteobacteria GT pyruvate phosphate dikinase - - - - - - - - - - - - NTP_transf_2,PPDK_N k59_695260_1 1333856.L686_16355 2.4e-46 155.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1Z0RB@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F ADP-ribose pyrophosphatase - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_695260_2 713586.KB900536_gene36 2.34e-41 138.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1X0ZV@135613|Chromatiales 135613|Chromatiales C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4 k59_140594_1 879212.DespoDRAFT_03348 8.37e-39 147.0 COG5360@1|root,COG5360@2|Bacteria,1MZ5X@1224|Proteobacteria,42PG1@68525|delta/epsilon subdivisions,2WP6V@28221|Deltaproteobacteria,2MI2Q@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Heparinase II - - - - - - - - - - - - Hepar_II_III,Hepar_II_III_N k59_500382_5 572544.Ilyop_0467 0.0 924.0 COG0446@1|root,COG1145@1|root,COG0446@2|Bacteria,COG1145@2|Bacteria,378BM@32066|Fusobacteria 2|Bacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.3.5.4,1.3.7.1 ko:K00244,ko:K20449 ko00020,ko00190,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164,R03164 RC00045,RC02422 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Fer4,Fer4_7,FrhB_FdhB_C,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_500382_6 1121342.AUCO01000003_gene1560 2.72e-45 150.0 COG3383@1|root,COG3383@2|Bacteria,1VAVK@1239|Firmicutes,24MYJ@186801|Clostridia,36KQK@31979|Clostridiaceae 186801|Clostridia C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2_4 k59_500382_7 572544.Ilyop_0465 5.26e-244 673.0 COG2423@1|root,COG2423@2|Bacteria 2|Bacteria E ornithine cyclodeaminase activity ocd - 1.5.1.51,4.3.1.12 ko:K01750,ko:K16182,ko:K21721 ko00300,ko00330,ko01110,ko01120,ko01130,ko01230,map00300,map00330,map01110,map01120,map01130,map01230 - R00671,R10012 RC00062,RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_500382_8 572544.Ilyop_0464 6.7e-259 719.0 COG1113@1|root,COG1113@2|Bacteria 2|Bacteria E amino acid transport eat - - ko:K16238 - - - - ko00000,ko02000 2.A.3.5 - - AA_permease,AA_permease_2 k59_173411_1 1473546.CH76_06230 3.93e-19 89.7 COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,4HACA@91061|Bacilli,3IWD6@400634|Lysinibacillus 91061|Bacilli S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_205777_1 1168034.FH5T_21905 3.13e-27 107.0 COG2334@1|root,COG2334@2|Bacteria,4NH00@976|Bacteroidetes,2FKYD@200643|Bacteroidia 976|Bacteroidetes S mucin-desulfating sulfatase mdsC - - - - - - - - - - - APH k59_205777_2 997829.HMPREF1121_00408 7.66e-40 141.0 COG0796@1|root,COG0796@2|Bacteria,4NG1C@976|Bacteroidetes,2FKYW@200643|Bacteroidia,22WDQ@171551|Porphyromonadaceae 976|Bacteroidetes M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_925293_1 1123376.AUIU01000001_gene791 2.29e-53 174.0 COG0378@1|root,COG0378@2|Bacteria,3J128@40117|Nitrospirae 40117|Nitrospirae KO CobW/HypB/UreG, nucleotide-binding domain hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_238176_1 888055.HMPREF9015_02184 5.39e-22 95.5 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 rgpB - - ko:K12997 - - - - ko00000,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_2 k59_141092_1 269799.Gmet_1092 9.87e-70 221.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42S6H@68525|delta/epsilon subdivisions,2WNDC@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_141092_2 562973.HMPREF0059_01878 3.24e-08 55.1 COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,4D3F7@85005|Actinomycetales 201174|Actinobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_727949_1 743718.Isova_0152 1.89e-88 275.0 COG1112@1|root,COG3662@1|root,COG1112@2|Bacteria,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,4F59G@85017|Promicromonosporaceae 201174|Actinobacteria L Uncharacterized protein conserved in bacteria (DUF2236) - - - - - - - - - - - - DUF2236 k59_565532_1 401526.TcarDRAFT_2304 1.09e-59 196.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4H3GZ@909932|Negativicutes 909932|Negativicutes I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_630630_1 1297865.APJD01000067_gene7059 7.72e-116 340.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,3JW35@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_930098_1 617140.AJZE01000078_gene1847 7.56e-69 225.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_342350_1 1265505.ATUG01000002_gene1479 1.66e-66 216.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,42MQU@68525|delta/epsilon subdivisions,2WK6F@28221|Deltaproteobacteria,2MN1R@213118|Desulfobacterales 28221|Deltaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_995220_1 385682.AFSL01000089_gene924 5.64e-53 184.0 COG1208@1|root,COG4412@1|root,COG1208@2|Bacteria,COG4412@2|Bacteria,4NI02@976|Bacteroidetes,2FR2W@200643|Bacteroidia 976|Bacteroidetes JM N-acetylglucosamine-1-phosphate uridyltransferase - - - - - - - - - - - - BACON,DUF4859 k59_471241_1 123899.JPQP01000020_gene2017 1.76e-92 288.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,3T1XK@506|Alcaligenaceae 28216|Betaproteobacteria I Long-chain acyl-CoA synthetases (AMP-forming) - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_635757_2 1380600.AUYN01000010_gene944 5.91e-15 73.2 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3 k59_961960_1 1168034.FH5T_21905 7.18e-104 309.0 COG2334@1|root,COG2334@2|Bacteria,4NH00@976|Bacteroidetes,2FKYD@200643|Bacteroidia 976|Bacteroidetes S mucin-desulfating sulfatase mdsC - - - - - - - - - - - APH k59_9006_1 1961.JOAK01000014_gene5545 8.28e-24 105.0 COG3321@1|root,COG3321@2|Bacteria,2H477@201174|Actinobacteria 201174|Actinobacteria Q polyketide synthase pks13 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006725,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009267,GO:0009273,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0016020,GO:0016043,GO:0016053,GO:0018958,GO:0019438,GO:0019725,GO:0019751,GO:0019752,GO:0022607,GO:0030003,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032787,GO:0032991,GO:0033554,GO:0034081,GO:0034311,GO:0034312,GO:0042546,GO:0042592,GO:0042594,GO:0042844,GO:0042845,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046173,GO:0046189,GO:0046394,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051704,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:0072330,GO:0097040,GO:0097041,GO:0097089,GO:0098771,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1902321 2.3.1.111,2.3.1.165,2.3.1.237,2.3.1.252 ko:K11628,ko:K12431,ko:K12432,ko:K12433,ko:K12437,ko:K12440,ko:K12441,ko:K12442,ko:K12443,ko:K15320,ko:K20422,ko:K21254,ko:K21792 ko00333,ko01059,ko01130,map00333,map01059,map01130 M00829,M00830,M00833,M00834,M00838 R05189,R07253,R11125,R11412,R11450,R11451,R11664 RC00004,RC00039,RC03439 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - iNJ661.Rv2934 ADH_N,ADH_zinc_N,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_79321_1 97139.C824_04459 2.32e-21 92.8 COG0012@1|root,COG0012@2|Bacteria,1UIBA@1239|Firmicutes,25EH3@186801|Clostridia,36S68@31979|Clostridiaceae 186801|Clostridia J GTP binding - - - - - - - - - - - - - k59_505927_1 469617.FUAG_00175 3.22e-86 258.0 COG0742@1|root,COG0742@2|Bacteria,378KW@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 8.96 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_505927_2 469616.FMAG_00276 5.45e-179 506.0 COG0809@1|root,COG0809@2|Bacteria,378U4@32066|Fusobacteria 32066|Fusobacteria H Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_505927_3 1216362.B437_06852 1.53e-115 348.0 COG2890@1|root,COG2890@2|Bacteria,378PJ@32066|Fusobacteria 32066|Fusobacteria J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_505927_4 1319815.HMPREF0202_01662 1.8e-184 521.0 COG0216@1|root,COG0216@2|Bacteria,3786N@32066|Fusobacteria 32066|Fusobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_505927_5 572544.Ilyop_1689 9.1e-12 63.2 COG3713@1|root,COG3713@2|Bacteria,37CA2@32066|Fusobacteria 32066|Fusobacteria M MltA-interacting MipA family protein - - - - - - - - - - - - - k59_79322_1 1122947.FR7_4174 3.17e-70 223.0 COG0673@1|root,COG0673@2|Bacteria,1UZEK@1239|Firmicutes,4H77I@909932|Negativicutes 909932|Negativicutes S PFAM oxidoreductase domain protein, Oxidoreductase domain-containing protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_79322_2 267608.RSc1247 2.66e-92 280.0 COG1082@1|root,COG1082@2|Bacteria,1R5PQ@1224|Proteobacteria,2VMJ4@28216|Betaproteobacteria,1KC8K@119060|Burkholderiaceae 28216|Betaproteobacteria G Xylose isomerase-like TIM barrel - - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_995237_1 1168034.FH5T_08765 1.07e-94 300.0 COG3250@1|root,COG3250@2|Bacteria,4NE7H@976|Bacteroidetes,2FN2H@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolase family 2, sugar binding domain protein csxA_2 - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_N k59_896551_1 207954.MED92_08291 0.0 1050.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1XI30@135619|Oceanospirillales 135619|Oceanospirillales I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadB - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_896551_2 207954.MED92_08296 1.67e-213 597.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1XHJA@135619|Oceanospirillales 135619|Oceanospirillales I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_896551_3 1353528.DT23_07025 5.87e-25 103.0 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,2U7ND@28211|Alphaproteobacteria,2XN7J@285107|Thioclava 28211|Alphaproteobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - MarR,MarR_2 k59_896551_4 1308866.J416_10621 9.02e-43 147.0 COG0454@1|root,COG0456@2|Bacteria,1V4R5@1239|Firmicutes,4HGWU@91061|Bacilli,470QM@74385|Gracilibacillus 91061|Bacilli K Acetyltransferase (GNAT) domain ectA - 2.3.1.178 ko:K06718 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06978 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_896551_5 472759.Nhal_2707 2e-233 651.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RQKU@1236|Gammaproteobacteria,1WXFB@135613|Chromatiales 135613|Chromatiales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_896551_6 717772.THIAE_06510 1.59e-68 209.0 COG1917@1|root,COG1917@2|Bacteria,1RDGQ@1224|Proteobacteria,1S41A@1236|Gammaproteobacteria,460WF@72273|Thiotrichales 72273|Thiotrichales S Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant ectC - 4.2.1.108 ko:K06720 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06979 RC01729 ko00000,ko00001,ko00002,ko01000 - - - Ectoine_synth k59_896551_7 472759.Nhal_0359 6.47e-158 453.0 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1WW7E@135613|Chromatiales 135613|Chromatiales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_896551_8 439235.Dalk_1233 1.48e-68 216.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,42T69@68525|delta/epsilon subdivisions,2WNN3@28221|Deltaproteobacteria,2MJYN@213118|Desulfobacterales 28221|Deltaproteobacteria S Haloacid dehalogenase-like hydrolase gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_896551_9 857087.Metme_0910 5.14e-05 50.8 COG3391@1|root,COG3391@2|Bacteria,1QUVX@1224|Proteobacteria,1RXP0@1236|Gammaproteobacteria,1XG40@135618|Methylococcales 135618|Methylococcales S alkaline phosphatase - - - - - - - - - - - - - k59_896551_10 768671.ThimaDRAFT_4229 3.78e-103 310.0 COG0697@1|root,COG0697@2|Bacteria,1RJFE@1224|Proteobacteria,1RZF0@1236|Gammaproteobacteria,1WWYW@135613|Chromatiales 135613|Chromatiales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_896551_11 1415779.JOMH01000001_gene1026 2.37e-276 794.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,1X9Y5@135614|Xanthomonadales 135614|Xanthomonadales S Protein export membrane protein - - - - - - - - - - - - MMPL k59_896551_12 32049.SYNPCC7002_A2560 9.84e-05 50.8 COG0406@1|root,COG0406@2|Bacteria,1G1TS@1117|Cyanobacteria,1GZ3A@1129|Synechococcus 1117|Cyanobacteria G Belongs to the phosphoglycerate mutase family gpmB - 3.1.3.3 ko:K22305 ko00260,ko00680,ko01100,ko01120,ko01130,map00260,map00680,map01100,map01120,map01130 - R00582 RC00017 ko00000,ko00001,ko01000 - - - His_Phos_1 k59_896551_13 868864.Dester_0088 7.25e-55 192.0 COG2074@1|root,COG2074@2|Bacteria,2G4F4@200783|Aquificae 200783|Aquificae G ATP cone domain - - - ko:K05715 - - R02664 RC00002,RC00017 ko00000,ko01000 - - - ATP-cone k59_896551_14 1316927.ATKI01000050_gene391 1.05e-30 109.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1YQV5@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K 'Cold-shock' DNA-binding domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_896551_15 1266925.JHVX01000006_gene2245 9.09e-79 258.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,372EM@32003|Nitrosomonadales 28216|Betaproteobacteria T Signal transduction histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_896551_16 85643.Tmz1t_0227 2.58e-90 272.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,2KUNU@206389|Rhodocyclales 206389|Rhodocyclales K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_896551_17 522306.CAP2UW1_1752 1.7e-146 417.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria 28216|Betaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_896551_18 1454004.AW11_02485 5.84e-138 396.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria 28216|Betaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system - - - - - - - - - - - - ABC_tran k59_896551_19 1454004.AW11_02486 7.71e-153 436.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria 28216|Betaproteobacteria P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_896551_20 522306.CAP2UW1_1749 4.46e-164 466.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria 28216|Betaproteobacteria P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_896551_21 1454004.AW11_02488 8.22e-103 314.0 COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria 2|Bacteria P negative regulation of phosphate transmembrane transport phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 1.20.4.1,3.1.3.48 ko:K01104,ko:K02039,ko:K03741 - - - - ko00000,ko01000 - - - PhoU k59_896551_22 1454004.AW11_02489 9.07e-144 412.0 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,2VTJU@28216|Betaproteobacteria 28216|Betaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_896551_23 1085623.GNIT_2795 3.95e-129 377.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,464TQ@72275|Alteromonadaceae 1236|Gammaproteobacteria BQ COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl k59_896551_24 1123401.JHYQ01000007_gene514 0.0 987.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,45ZVX@72273|Thiotrichales 72273|Thiotrichales C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_896551_25 1049564.TevJSym_ac01690 1.44e-79 246.0 COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1JA86@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 k59_896551_27 1123392.AQWL01000011_gene2234 4.6e-79 253.0 COG4360@1|root,COG4360@2|Bacteria,1RB5I@1224|Proteobacteria,2W0KI@28216|Betaproteobacteria,1KS44@119069|Hydrogenophilales 119069|Hydrogenophilales F ATP adenylyltransferase (5',5''-P-1,P-4-tetraphosphate phosphorylase II) - - - - - - - - - - - - - k59_274523_1 1216007.AOPM01000028_gene3559 7.12e-36 127.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,2Q074@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J Forms part of the polypeptide exit tunnel rplD GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_274523_2 547045.NEISICOT_02474 1.59e-15 72.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,2KRGC@206351|Neisseriales 206351|Neisseriales J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_732707_1 563040.Saut_1256 4.28e-102 311.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_732707_2 929558.SMGD1_2778 2.31e-59 200.0 COG2199@1|root,COG3706@2|Bacteria,1Q5A3@1224|Proteobacteria,430W0@68525|delta/epsilon subdivisions,2YRZB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF k59_342938_1 765910.MARPU_13775 7.94e-09 56.2 COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,1RQ41@1236|Gammaproteobacteria,1WXEC@135613|Chromatiales 135613|Chromatiales S subfamily IA, variant 1 - - 3.1.3.102,3.1.3.104 ko:K20862 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00548,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD_2 k59_342938_2 2340.JV46_21850 1.2e-48 163.0 COG2356@1|root,COG2356@2|Bacteria,1MXQM@1224|Proteobacteria,1RPX9@1236|Gammaproteobacteria,1JB5I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease I endA - 3.1.21.1 ko:K01150 - - - - ko00000,ko01000 - - - Endonuclease_1 k59_831742_1 1123354.AUDR01000015_gene351 9.94e-35 122.0 COG1371@1|root,COG1371@2|Bacteria 2|Bacteria J PFAM Archease protein family (DUF101 UPF0211) - - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Archease k59_795641_1 1165841.SULAR_00075 1.92e-79 251.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2YMBM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J ribosomal protein S1 rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_795641_2 387093.SUN_0551 1.91e-27 109.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2YMF3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_995815_1 582744.Msip34_0682 2.83e-114 347.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KKKI@206350|Nitrosomonadales 206350|Nitrosomonadales CP TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_732710_1 991905.SL003B_1945 5.13e-17 85.5 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,4BQRK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Phosphate transporter family pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_669426_1 675816.VIA_001665 4.07e-54 190.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1XV4P@135623|Vibrionales 135623|Vibrionales M Outer membrane efflux protein VPA1579 - - - - - - - - - - - OEP k59_732718_1 1469245.JFBG01000097_gene1356 8.11e-95 285.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_274536_1 335659.S23_24510 4.5e-16 84.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JR0R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Response regulator receiver - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg k59_570551_1 1123274.KB899410_gene3384 3.24e-76 247.0 COG3968@1|root,COG3968@2|Bacteria,2J5PV@203691|Spirochaetes 203691|Spirochaetes S PFAM Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C k59_897141_1 517417.Cpar_2036 1.47e-73 234.0 COG0531@1|root,COG0531@2|Bacteria,1FESF@1090|Chlorobi 1090|Chlorobi E PFAM amino acid permease-associated region - - - - - - - - - - - - AA_permease_2 k59_112812_1 929558.SMGD1_1312 1.08e-92 285.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,42P57@68525|delta/epsilon subdivisions,2YMGG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_795654_1 865937.Gilli_3416 1.02e-32 117.0 2E4GQ@1|root,32ZBW@2|Bacteria,4NWCC@976|Bacteroidetes,1I57G@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_766265_1 1232683.ADIMK_3977 2.79e-126 372.0 COG0391@1|root,COG0391@2|Bacteria,1NW3K@1224|Proteobacteria,1RQP9@1236|Gammaproteobacteria,4667U@72275|Alteromonadaceae 1236|Gammaproteobacteria S Uncharacterised protein family UPF0052 - - - - - - - - - - - - UPF0052 k59_211683_1 631362.Thi970DRAFT_01516 1.09e-155 461.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1WW2Y@135613|Chromatiales 135613|Chromatiales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_146687_1 1464048.JNZS01000007_gene4580 7.92e-09 57.4 COG0736@1|root,COG0736@2|Bacteria,2IPP4@201174|Actinobacteria 201174|Actinobacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein - - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_406642_1 565045.NOR51B_2004 1.57e-45 160.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1J5K7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion macA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_406642_2 1348657.M622_11865 1.86e-59 191.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJBY@28216|Betaproteobacteria,2KVSB@206389|Rhodocyclales 206389|Rhodocyclales V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_831768_1 1316936.K678_09106 3.14e-06 50.4 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,2JSSB@204441|Rhodospirillales 204441|Rhodospirillales S Phosphoglycolate phosphatase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_831768_2 1415754.JQMK01000005_gene1696 1.61e-46 157.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,464RA@72275|Alteromonadaceae 1236|Gammaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2376 Methyltransf_23 k59_506609_1 1049564.TevJSym_bv00160 1.03e-45 156.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,1J73F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein family (UPF0014) ybbM GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0015075,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0030003,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098771 - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_146709_1 105559.Nwat_1826 1.6e-14 70.5 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1WY06@135613|Chromatiales 135613|Chromatiales I Cyclase dehydrase - - - - - - - - - - - - Polyketide_cyc k59_146709_2 748658.KB907313_gene2188 1.46e-36 127.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1WX50@135613|Chromatiales 135613|Chromatiales O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_766298_1 857293.CAAU_1940 5.1e-41 147.0 COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,36DXS@31979|Clostridiaceae 186801|Clostridia I Alpha beta - - - - - - - - - - - - Hydrolase_4 k59_962587_2 887062.HGR_09099 2.45e-24 94.4 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,4AEBZ@80864|Comamonadaceae 28216|Betaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_603920_1 2340.JV46_10460 1.32e-13 65.9 COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,1S9CV@1236|Gammaproteobacteria 1236|Gammaproteobacteria P nitrite reductase nirD - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske,Rieske_2 k59_603920_2 1123401.JHYQ01000035_gene3487 2.46e-36 137.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,45ZRS@72273|Thiotrichales 72273|Thiotrichales C TIGRFAM nitrite reductase NAD(P)H , large subunit - - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_897190_1 1499967.BAYZ01000080_gene910 0.000426 48.1 COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - - - - - - - - - - - Big_5,ESPR,LVIVD,YadA_anchor,YadA_head,YadA_stalk k59_45554_1 1121918.ARWE01000001_gene105 1.34e-174 505.0 COG1132@1|root,COG1132@2|Bacteria,1MXC2@1224|Proteobacteria,42PQK@68525|delta/epsilon subdivisions,2WJCT@28221|Deltaproteobacteria,43T12@69541|Desulfuromonadales 28221|Deltaproteobacteria V ABC transporter - - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_308143_1 1168034.FH5T_03595 1.11e-81 256.0 COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,2FN75@200643|Bacteroidia 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_570600_1 1123355.JHYO01000014_gene1051 5.39e-33 131.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,36XKH@31993|Methylocystaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg k59_247331_1 742727.HMPREF9447_02804 5.14e-86 266.0 COG0180@1|root,COG0180@2|Bacteria,4NETX@976|Bacteroidetes,2FMAT@200643|Bacteroidia,4AP4X@815|Bacteroidaceae 976|Bacteroidetes J Belongs to the class-I aminoacyl-tRNA synthetase family trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_150588_1 1304885.AUEY01000013_gene3109 2.42e-24 107.0 COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MI01@213118|Desulfobacterales 28221|Deltaproteobacteria S metal-dependent phosphohydrolase 7TM intracellular region - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_347016_1 1219045.BV98_002691 2.38e-09 54.7 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2K5CA@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_347016_2 255470.cbdbA1487 2.95e-37 132.0 COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia 301297|Dehalococcoidia L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_150593_1 999541.bgla_1g33430 2.53e-08 55.5 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,1K09V@119060|Burkholderiaceae 28216|Betaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_150593_2 1142394.PSMK_23710 1.8e-13 70.1 COG0659@1|root,COG0659@2|Bacteria,2IXMF@203682|Planctomycetes 203682|Planctomycetes P COG0659 Sulfate permease and related - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_999852_2 1565314.OA34_08150 1.61e-36 136.0 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,42QJJ@68525|delta/epsilon subdivisions,2YTPK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M glycosyl transferase - - - ko:K13007 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_835810_1 269799.Gmet_1879 1.33e-71 231.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,43TBU@69541|Desulfuromonadales 28221|Deltaproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_867984_1 865861.AZSU01000003_gene2170 3.15e-74 235.0 COG3493@1|root,COG3493@2|Bacteria,1TR97@1239|Firmicutes,24BDA@186801|Clostridia,36GMZ@31979|Clostridiaceae 186801|Clostridia C 2-hydroxycarboxylate transporter family citP - - ko:K11616 ko02020,map02020 - - - ko00000,ko00001 2.A.24.2 - - 2HCT k59_312011_1 713586.KB900536_gene2811 1.54e-24 104.0 COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2FP@1236|Gammaproteobacteria,1WWXW@135613|Chromatiales 135613|Chromatiales C PFAM 2Fe-2S iron-sulfur cluster binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2 k59_312011_2 686340.Metal_0305 3.04e-21 87.4 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1XFC6@135618|Methylococcales 135618|Methylococcales S PFAM Stringent starvation protein B sspB - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_13507_1 177437.HRM2_41800 3.81e-206 588.0 2DBU2@1|root,2ZB3S@2|Bacteria,1N1MT@1224|Proteobacteria,42VJX@68525|delta/epsilon subdivisions,2WSPP@28221|Deltaproteobacteria,2MNKM@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - DDE_Tnp_1_4 k59_640333_1 29495.EA26_17385 1.7e-05 47.4 COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,1XSRD@135623|Vibrionales 135623|Vibrionales S Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_278990_5 522306.CAP2UW1_4043 1.72e-19 83.6 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,1KR6J@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_868487_1 1033802.SSPSH_002154 1.61e-60 200.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125 GATase_6,GATase_7,Pribosyltran k59_216264_1 1168034.FH5T_10115 1.86e-90 274.0 COG1052@1|root,COG1052@2|Bacteria,4NIHV@976|Bacteroidetes,2FPG0@200643|Bacteroidia 976|Bacteroidetes C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family hprA - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_705725_1 1461579.CCNK01000007_gene61 7.98e-10 58.9 COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,1RPYU@1236|Gammaproteobacteria 1236|Gammaproteobacteria E homoserine dehydrogenase - - - - - - - - - - - - DapB_N k59_1031790_1 387093.SUN_0711 1.93e-65 212.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2YMTP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_640830_1 1121875.KB907547_gene3129 3.4e-75 230.0 COG0580@1|root,COG0580@2|Bacteria,4NFW4@976|Bacteroidetes,1HXX1@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the MIP aquaporin (TC 1.A.8) family aqpZ - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP k59_901662_1 1168034.FH5T_20175 4.03e-100 301.0 COG1538@1|root,COG1538@2|Bacteria,4NIE8@976|Bacteroidetes,2FNS5@200643|Bacteroidia 976|Bacteroidetes MU outer membrane efflux protein - - - - - - - - - - - - OEP k59_49958_1 929558.SMGD1_1154 1.01e-82 246.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,42SNY@68525|delta/epsilon subdivisions,2YNVI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_49958_2 326298.Suden_2021 5.86e-38 129.0 COG2921@1|root,COG2921@2|Bacteria,1Q61Q@1224|Proteobacteria,42WSH@68525|delta/epsilon subdivisions,2YQB4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0250 family - - - - - - - - - - - - DUF493 k59_49958_3 929558.SMGD1_1156 6.33e-97 296.0 2AIMJ@1|root,3193W@2|Bacteria,1Q1QU@1224|Proteobacteria,42U73@68525|delta/epsilon subdivisions,2YSXF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_183748_1 1408473.JHXO01000008_gene2754 4.77e-153 448.0 COG1132@1|root,COG1132@2|Bacteria,4NFF7@976|Bacteroidetes,2G2XQ@200643|Bacteroidia 976|Bacteroidetes V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_511011_1 1249627.D779_3281 2.54e-87 262.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1WWM8@135613|Chromatiales 135613|Chromatiales IQ TIGRFAM acetoacetyl-CoA reductase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_836295_1 700598.Niako_6103 2.91e-97 304.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1INUX@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_378831_2 1216966.BAUC01000039_gene2924 1.05e-51 171.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_868518_1 228405.HNE_1312 5.93e-51 171.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,43WBF@69657|Hyphomonadaceae 28211|Alphaproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain ragA GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_84423_1 1049564.TevJSym_br00020 1.07e-100 328.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_800224_1 1049564.TevJSym_bp00150 9.57e-102 303.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1J4QF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3,2.1.3.6,2.1.3.9 ko:K00611,ko:K09065,ko:K13252 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01398,R07245 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_279014_1 555779.Dthio_PD3802 1.23e-36 147.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_608263_1 386415.NT01CX_0627 1.31e-159 455.0 COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,36FA1@31979|Clostridiaceae 186801|Clostridia E phospho-2-dehydro-3-deoxyheptonate aldolase aroF - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS14395 DAHP_synth_1 k59_608263_2 332101.JIBU02000012_gene922 1.27e-34 127.0 COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,36DNM@31979|Clostridiaceae 186801|Clostridia E prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_511022_1 443598.AUFA01000002_gene2783 7.06e-27 114.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1 k59_673987_1 1286171.EAL2_808p06700 7.91e-93 286.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,25V7V@186806|Eubacteriaceae 186801|Clostridia S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_443291_1 765912.Thimo_3383 3.91e-08 54.3 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1WW2W@135613|Chromatiales 135613|Chromatiales P PFAM sodium hydrogen exchanger - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_49982_1 1121451.DESAM_20551 3.34e-19 94.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2M7YN@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase nifM - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_967250_1 1040989.AWZU01000003_gene6809 1.72e-16 80.5 COG3247@1|root,COG3247@2|Bacteria,1RCX3@1224|Proteobacteria,2U8BM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_378849_2 1116472.MGMO_124c00060 2.23e-46 157.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1XDWH@135618|Methylococcales 135618|Methylococcales E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_674002_1 240016.ABIZ01000001_gene5347 1.56e-36 136.0 COG1596@1|root,COG1596@2|Bacteria,46XCW@74201|Verrucomicrobia,2IVGU@203494|Verrucomicrobiae 203494|Verrucomicrobiae M Polysaccharide biosynthesis/export protein - - - - - - - - - - - - Poly_export,SLBB k59_443306_1 1026882.MAMP_01558 1.95e-48 166.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,460MK@72273|Thiotrichales 72273|Thiotrichales M Lipid A biosynthesis lpxL - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_967261_1 349124.Hhal_1396 9.77e-60 205.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_967262_2 1120963.KB894498_gene2324 8.55e-13 67.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,2Q03R@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_216320_1 1177928.TH2_19038 1.41e-76 238.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria,2JPB6@204441|Rhodospirillales 204441|Rhodospirillales G COG2513 PEP phosphonomutase and related enzymes - - - - - - - - - - - - PEP_mutase k59_934880_1 526218.Sterm_1874 1.22e-88 266.0 COG1051@1|root,COG1051@2|Bacteria,37AAQ@32066|Fusobacteria 32066|Fusobacteria F Hydrolase, NUDIX family - - - - - - - - - - - - NUDIX,Nudix_N k59_608293_1 1280950.HJO_07282 6.28e-65 214.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2TVI9@28211|Alphaproteobacteria 28211|Alphaproteobacteria O CAAX prenyl protease N-terminal, five membrane helices - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_279049_1 713586.KB900536_gene951 4.73e-65 203.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria,1WY0J@135613|Chromatiales 135613|Chromatiales H molybdopterin-guanine dinucleotide biosynthesis protein mobB - - ko:K03753 - - - - ko00000 - - - MobB k59_50013_1 641491.DND132_2504 3.04e-09 63.5 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_14098_1 1167006.UWK_01566 2.64e-60 200.0 COG0332@1|root,COG0332@2|Bacteria,1NAGY@1224|Proteobacteria,42P7S@68525|delta/epsilon subdivisions,2WKT4@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III_C k59_50024_1 768671.ThimaDRAFT_4368 3.7e-208 591.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1WW8W@135613|Chromatiales 135613|Chromatiales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_84471_1 886379.AEWI01000037_gene2928 4.94e-36 133.0 COG0297@1|root,COG0297@2|Bacteria,4PKP8@976|Bacteroidetes,2G0CZ@200643|Bacteroidia,3XJKP@558415|Marinilabiliaceae 976|Bacteroidetes G Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glyco_transf_5,Glycos_transf_1 k59_84471_2 1408473.JHXO01000001_gene2384 1.66e-53 181.0 COG1449@1|root,COG1449@2|Bacteria,4NFXW@976|Bacteroidetes,2FMRY@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 57 family amyA - 3.2.1.1 ko:K07405 ko00500,ko01100,map00500,map01100 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH57 - Glyco_hydro_57 k59_705822_2 1056512.D515_01527 2.95e-14 73.2 COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,1RNUR@1236|Gammaproteobacteria,1XU9Z@135623|Vibrionales 135623|Vibrionales E Enzyme with broad specificity iaaA - 3.4.19.5 ko:K13051 - - - - ko00000,ko01000,ko01002 - - - Asparaginase_2 k59_50028_1 398767.Glov_0139 2.07e-41 144.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - - - - - - - - - - MerR_1,TipAS k59_770979_1 1168034.FH5T_06155 6.85e-132 389.0 COG0029@1|root,COG0029@2|Bacteria,4NGUE@976|Bacteroidetes,2FNMT@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_901725_1 1206743.BAGM01000094_gene4510 1.23e-53 183.0 COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,2GMWU@201174|Actinobacteria,4FTZF@85025|Nocardiaceae 201174|Actinobacteria K Predicted transcriptional regulator (DUF2083) - GO:0001666,GO:0006082,GO:0006355,GO:0006629,GO:0006631,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016999,GO:0017144,GO:0019219,GO:0019222,GO:0019541,GO:0019679,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0036293,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044403,GO:0044419,GO:0046459,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070482,GO:0071704,GO:0075136,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K07110,ko:K21686 - - - - ko00000,ko03000 - - - DUF2083,HTH_3,HTH_31,Peptidase_M78 k59_934904_1 411463.EUBVEN_02307 1e-88 273.0 COG0371@1|root,COG0371@2|Bacteria,1TQFU@1239|Firmicutes,248KH@186801|Clostridia,25VZZ@186806|Eubacteriaceae 186801|Clostridia C Iron-containing alcohol dehydrogenase - - 1.1.1.6 ko:K00005 ko00561,ko00640,ko01100,map00561,map00640,map01100 - R01034,R10715,R10717 RC00029,RC00117,RC00670 ko00000,ko00001,ko01000 - - - Fe-ADH k59_279085_1 545264.KB898744_gene2016 1.45e-73 231.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_117567_1 1049564.TevJSym_aq00390 5.71e-88 267.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1J52T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_934908_1 2340.JV46_24780 8.3e-30 113.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1J62G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG3175 Cytochrome oxidase assembly factor ctaG - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_934908_3 297246.lpp2961 2.7e-08 54.3 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1JCDQ@118969|Legionellales 118969|Legionellales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxA - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_50064_1 768671.ThimaDRAFT_2295 2.67e-81 261.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales 135613|Chromatiales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_216355_1 1335757.SPICUR_06990 1.41e-07 52.4 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1WW7J@135613|Chromatiales 135613|Chromatiales F Ribonucleotide reductase, barrel domain - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_216355_2 187272.Mlg_1471 6.03e-97 310.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_836372_1 1027273.GZ77_23920 9.5e-72 236.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XHJY@135619|Oceanospirillales 135619|Oceanospirillales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_476471_1 573065.Astex_0083 1.27e-13 78.2 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,2KFNF@204458|Caulobacterales 204458|Caulobacterales L Belongs to the helicase family. UvrD subfamily - - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_705875_1 1121898.Q766_20710 1.51e-06 55.5 COG3291@1|root,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia,2NSSE@237|Flavobacterium 976|Bacteroidetes O gliding motility-associated C-terminal domain - - - - - - - - - - - - CHU_C,PKD k59_347546_1 1163617.SCD_n01539 1.65e-215 606.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2WH9U@28216|Betaproteobacteria 28216|Betaproteobacteria I acetyl-CoA carboxylase, biotin carboxylase - - 6.4.1.1 ko:K01959 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_967323_1 1111732.AZOD01000014_gene1507 8.99e-22 95.5 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S6CS@1236|Gammaproteobacteria,1X7K7@135614|Xanthomonadales 135614|Xanthomonadales C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_674091_1 335543.Sfum_1925 1.65e-53 189.0 COG0699@1|root,COG0699@2|Bacteria,1R3WJ@1224|Proteobacteria,42N0G@68525|delta/epsilon subdivisions,2WKFJ@28221|Deltaproteobacteria,2MRED@213462|Syntrophobacterales 28221|Deltaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_443360_1 981384.AEYW01000028_gene4248 3.4e-30 119.0 2F138@1|root,33U4R@2|Bacteria,1NUMP@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_443360_2 981384.AEYW01000028_gene4249 9.3e-54 181.0 COG1409@1|root,COG1409@2|Bacteria,1NI34@1224|Proteobacteria 1224|Proteobacteria S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_1031919_1 1159870.KB907784_gene2237 1.74e-71 234.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,3T34S@506|Alcaligenaceae 28216|Betaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K02021,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_476484_1 1121015.N789_00810 1.66e-68 224.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1X3PI@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_476484_2 267608.RSc0948 3.18e-20 90.9 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VJ15@28216|Betaproteobacteria,1K4KC@119060|Burkholderiaceae 28216|Betaproteobacteria E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1031920_1 1255043.TVNIR_1749 1.94e-80 245.0 COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,1RPTD@1236|Gammaproteobacteria,1X0N0@135613|Chromatiales 135613|Chromatiales C Nitrate reductase gamma subunit narI - 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Nitrate_red_gam k59_575360_1 177437.HRM2_48370 3.02e-12 73.2 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MICU@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_511091_1 871968.DESME_11675 1.2e-49 173.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia,263DU@186807|Peptococcaceae 186801|Clostridia S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_996234_1 768671.ThimaDRAFT_0847 3.2e-49 175.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SA31@1236|Gammaproteobacteria 1224|Proteobacteria T SMART ATP-binding region, ATPase-like - - - - - - - - - - - - HATPase_c,HisKA,PAS_3 k59_308511_1 62928.azo1779 6.98e-19 88.6 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VWQD@28216|Betaproteobacteria 28216|Betaproteobacteria V Ami_2 - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_308511_2 929556.Solca_3101 2.7e-16 75.5 2ER3W@1|root,33IPG@2|Bacteria,4NYM0@976|Bacteroidetes,1J030@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_571074_1 1123073.KB899241_gene1972 6.61e-85 272.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1XBWN@135614|Xanthomonadales 135614|Xanthomonadales S M61 glycyl aminopeptidase - - - - - - - - - - - - Peptidase_M61 k59_897588_1 754476.Q7A_1978 1.05e-43 145.0 COG4633@1|root,COG4633@2|Bacteria,1N6VB@1224|Proteobacteria,1SDG5@1236|Gammaproteobacteria,4619I@72273|Thiotrichales 72273|Thiotrichales S Cupredoxin-like domain - - - - - - - - - - - - Cupredoxin_1 k59_931042_1 929558.SMGD1_1614 1.79e-20 88.6 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2YN3F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_472239_1 869213.JCM21142_72613 8.56e-162 465.0 COG0845@1|root,COG0845@2|Bacteria,4NF0X@976|Bacteroidetes,47P9V@768503|Cytophagia 976|Bacteroidetes M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_701612_1 1049564.TevJSym_bu00040 2.32e-74 250.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1J4ZQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_113278_3 1524882.A0A076GD16_9CAUD 4.84e-14 74.3 4QGIT@10239|Viruses,4QQNT@28883|Caudovirales,4QMVR@10699|Siphoviridae 10699|Siphoviridae S viral capsid - - - - - - - - - - - - - k59_472244_1 1049564.TevJSym_ad00310 1.35e-40 145.0 2E6HP@1|root,3314Y@2|Bacteria,1QGPJ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_45991_1 1121875.KB907546_gene2204 8.2e-38 137.0 COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia 976|Bacteroidetes Q Imidazolonepropionase and related - - - - - - - - - - - - Amidohydro_1 k59_539230_1 880073.Calab_1544 3.16e-11 64.7 COG3342@1|root,COG3342@2|Bacteria,2NP87@2323|unclassified Bacteria 2|Bacteria S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028,TPR_16,TPR_19 k59_539230_2 1111728.ATYS01000010_gene189 1.69e-06 52.0 COG3193@1|root,COG3193@2|Bacteria,1RK4B@1224|Proteobacteria,1S256@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_113281_1 1168034.FH5T_08440 8.04e-113 353.0 COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,2FKYY@200643|Bacteroidia 976|Bacteroidetes P Psort location OuterMembrane, score - - - - - - - - - - - - CarboxypepD_reg,TonB_dep_Rec k59_243720_1 573061.Clocel_3456 1.35e-43 159.0 COG0189@1|root,COG2918@1|root,COG0189@2|Bacteria,COG2918@2|Bacteria,1TPGX@1239|Firmicutes,25ER3@186801|Clostridia,36URU@31979|Clostridiaceae 186801|Clostridia HJ belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily gshF - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase,RimK k59_243720_2 743719.PaelaDRAFT_3116 7.19e-18 79.3 COG0526@1|root,COG0526@2|Bacteria,1VFUD@1239|Firmicutes,4HNQS@91061|Bacilli,26ZVG@186822|Paenibacillaceae 91061|Bacilli CO Thioredoxin ydfQ - - - - - - - - - - - Thioredoxin k59_962995_2 1298593.TOL_0159 3.47e-30 113.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1XHIV@135619|Oceanospirillales 135619|Oceanospirillales T phosphate regulon transcriptional regulatory protein PhoB phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_796117_1 1249627.D779_4189 7.5e-133 419.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1141@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1141@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales 135613|Chromatiales C pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_996272_1 377629.TERTU_4019 2.04e-89 285.0 COG5297@1|root,COG5297@2|Bacteria,1QZ9W@1224|Proteobacteria,1RPFR@1236|Gammaproteobacteria,2PP89@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Glycosyl hydrolase family 9 - - - - - - - - - - - - CBM_2,Glyco_hydro_9 k59_864417_1 698440.XP_007294090.1 5.38e-53 192.0 COG0525@1|root,KOG0432@2759|Eukaryota,38BX5@33154|Opisthokonta,3NXM3@4751|Fungi,3QNQ0@4890|Ascomycota,20WX9@147548|Leotiomycetes 4751|Fungi J Belongs to the class-I aminoacyl-tRNA synthetase family VAS1 GO:0000166,GO:0002181,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061475,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_864417_5 396513.SCA_1555 6.85e-38 141.0 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,4HANB@91061|Bacilli,4GXPP@90964|Staphylococcaceae 91061|Bacilli J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_374790_1 1121441.AUCX01000006_gene1001 1.6e-78 244.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,42P5M@68525|delta/epsilon subdivisions,2WMFW@28221|Deltaproteobacteria,2M8VX@213115|Desulfovibrionales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_80398_1 187272.Mlg_1805 1.92e-105 313.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1WWPU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_113329_1 519989.ECTPHS_10124 2.09e-88 289.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_308551_1 1123511.KB905841_gene1357 1.24e-98 299.0 COG0673@1|root,COG0673@2|Bacteria,1TQSS@1239|Firmicutes,4H3TG@909932|Negativicutes 909932|Negativicutes S Oxidoreductase NAD-binding domain protein - - - ko:K22230 ko00562,ko01120,map00562,map01120 - R09954 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_308551_2 595494.Tola_1650 1.52e-122 362.0 COG0451@1|root,COG0451@2|Bacteria,1Q2DG@1224|Proteobacteria,1RSQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM NAD dependent epimerase/dehydratase family - - - - - - - - - - - - Epimerase k59_308551_3 1294142.CINTURNW_1083 2.91e-68 216.0 COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,248MV@186801|Clostridia,36EYN@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_571109_1 765912.Thimo_2000 2.57e-124 360.0 COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,1RNJ0@1236|Gammaproteobacteria,1WWCA@135613|Chromatiales 135613|Chromatiales D Belongs to the ParA family - - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_963031_2 1094715.CM001373_gene400 7.16e-52 171.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1JDNK@118969|Legionellales 118969|Legionellales H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_996274_1 864073.HFRIS_012329 4.12e-77 236.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,4763Z@75682|Oxalobacteraceae 28216|Betaproteobacteria S Belongs to the LOG family yvdD_2 - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_212795_1 2340.JV46_14290 2.27e-84 269.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_10655_1 1121035.AUCH01000004_gene429 2.36e-77 259.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_114025_1 1304865.JAGF01000001_gene2659 1.39e-83 251.0 COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4F116@85016|Cellulomonadaceae 201174|Actinobacteria T PFAM response regulator receiver mtrA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K07670 ko02020,map02020 M00461 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_114025_2 593907.Celgi_1133 8.81e-14 74.7 COG5002@1|root,COG5002@2|Bacteria,2GJ2D@201174|Actinobacteria,4F0S8@85016|Cellulomonadaceae 201174|Actinobacteria T histidine kinase HAMP region domain protein mtrB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.7.13.3 ko:K07636,ko:K07654 ko02020,map02020 M00434,M00461 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_767582_1 570967.JMLV01000001_gene2799 1.51e-149 428.0 2DG8R@1|root,2ZUYV@2|Bacteria,1R8VA@1224|Proteobacteria,2VGKJ@28211|Alphaproteobacteria,2JZ9B@204441|Rhodospirillales 204441|Rhodospirillales H Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_375489_1 1249480.B649_10855 0.000737 47.0 COG1426@1|root,COG1426@2|Bacteria,1Q33C@1224|Proteobacteria,42WQB@68525|delta/epsilon subdivisions,2YQFX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_275680_1 589865.DaAHT2_2486 6.16e-60 194.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WJHD@28221|Deltaproteobacteria,2MJ10@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM dihydropteroate synthase DHPS - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_407753_1 1101195.Meth11DRAFT_2513 2.83e-06 49.7 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria,2KKTU@206350|Nitrosomonadales 206350|Nitrosomonadales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_407753_2 338969.Rfer_1280 4.58e-30 117.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,4AADP@80864|Comamonadaceae 28216|Betaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_865128_1 269796.Rru_A2215 1.61e-28 112.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,2JQUN@204441|Rhodospirillales 204441|Rhodospirillales K LysR substrate binding domain - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_407755_1 558169.AGAV01000003_gene2883 2.07e-11 68.9 COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,4HBBA@91061|Bacilli 91061|Bacilli E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_931659_1 933262.AXAM01000056_gene3177 1.43e-61 206.0 COG0247@1|root,COG1908@1|root,COG0247@2|Bacteria,COG1908@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MIBB@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8,Fer4_9,FlpD k59_931660_1 272568.GDI0183 9.76e-13 69.7 COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,2JS8Z@204441|Rhodospirillales 204441|Rhodospirillales S to the N-terminal domain of Lon protease lonD - 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - LON_substr_bdg k59_767594_1 572477.Alvin_2508 1.52e-116 348.0 COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,1RMJT@1236|Gammaproteobacteria,1WWC2@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation sthA - 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_81029_1 1380394.JADL01000001_gene2569 2.79e-15 79.0 2EDW0@1|root,32VXH@2|Bacteria,1R3JT@1224|Proteobacteria,2U03S@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_898380_1 644282.Deba_3201 1.25e-12 67.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Thiamine pyrophosphate - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_898380_2 335543.Sfum_0115 1.21e-13 73.6 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MQT4@213462|Syntrophobacterales 28221|Deltaproteobacteria C ferredoxin oxidoreductase alpha subunit - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_344049_1 926556.Echvi_4552 9.86e-47 171.0 COG3533@1|root,COG3533@2|Bacteria,4NF8W@976|Bacteroidetes,47NXX@768503|Cytophagia 976|Bacteroidetes S Bacterial Ig-like domain (group 4) - - - ko:K09955 - - - - ko00000 - - - Big_4,Glyco_hydro_127,Laminin_G_3 k59_637503_1 1454004.AW11_00144 5.3e-25 101.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,1KQQW@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III cyc - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_996991_1 519989.ECTPHS_01549 2.49e-72 229.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_865151_1 545693.BMQ_1857 7.69e-37 137.0 COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,4HADZ@91061|Bacilli,1ZB1T@1386|Bacillus 91061|Bacilli G Converts alpha-aldose to the beta-anomer mro - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_865151_2 572544.Ilyop_1681 9.43e-111 326.0 COG1087@1|root,COG1087@2|Bacteria,378JK@32066|Fusobacteria 32066|Fusobacteria M UDP-glucose 4-epimerase galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_407781_1 1121129.KB903359_gene1523 3.25e-50 172.0 COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,2FNVV@200643|Bacteroidia,22VWR@171551|Porphyromonadaceae 976|Bacteroidetes E Catalyzes the hydrolysis of Xaa-His dipeptides pepD_1 - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_407781_2 1121011.AUCB01000039_gene945 3.85e-92 291.0 COG1073@1|root,COG1073@2|Bacteria,4PKM0@976|Bacteroidetes,1IJCB@117743|Flavobacteriia 976|Bacteroidetes S alpha beta - - - - - - - - - - - - Lipase_GDSL_2,Peptidase_S9 k59_865159_1 1121405.dsmv_3267 4e-70 228.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales 28221|Deltaproteobacteria J ribonuclease Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_244474_1 1049564.TevJSym_at00390 1.1e-117 353.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1J4IR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 - ko:K03688 - - - - ko00000 - - iYL1228.KPN_04331 ABC1 k59_244474_2 765910.MARPU_15940 8.04e-18 80.9 COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1WWJP@135613|Chromatiales 135613|Chromatiales S Sterol-binding domain protein - - - ko:K03690 - - - - ko00000 - - - SCP2 k59_865161_1 306263.Cla_0627 1.06e-13 71.2 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2YMMP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the peptidase M16 family pqqL - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_865161_2 929558.SMGD1_2479 2.26e-51 170.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2YN2X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_898416_1 1121448.DGI_2643 5.13e-92 283.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_796873_1 35754.JNYJ01000018_gene9647 3.82e-11 67.0 COG3401@1|root,COG4733@1|root,COG3401@2|Bacteria,COG4733@2|Bacteria,2GMCU@201174|Actinobacteria,4D9RG@85008|Micromonosporales 201174|Actinobacteria G FG-GAP repeat protein - - - - - - - - - - - - CBM_2 k59_733914_1 158189.SpiBuddy_2161 2.82e-08 59.7 COG1355@1|root,COG1355@2|Bacteria 2|Bacteria C regulation of microtubule-based process - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_571830_1 1210884.HG799462_gene9193 2.66e-25 110.0 COG0507@1|root,COG0507@2|Bacteria,2J438@203682|Planctomycetes 203682|Planctomycetes L TrwC relaxase - - - - - - - - - - - - TrwC k59_997000_1 349124.Hhal_1654 7.61e-12 63.9 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales 135613|Chromatiales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_244483_1 95619.PM1_0201865 6.22e-98 299.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1028518_1 1122201.AUAZ01000008_gene423 1.89e-206 578.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,465AH@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1028518_2 1049564.TevJSym_ar00160 2.2e-208 582.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1J4KU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082 Iso_dh k59_1028518_3 765911.Thivi_0923 2.04e-111 324.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1WW8F@135613|Chromatiales 135613|Chromatiales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_1028518_4 1049564.TevJSym_ar00180 7.95e-266 736.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1J51D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1028518_5 247633.GP2143_04735 3.89e-90 276.0 COG0583@1|root,COG0583@2|Bacteria,1NSNV@1224|Proteobacteria,1RPNG@1236|Gammaproteobacteria,1J5PN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator cmpR_1 - - - - - - - - - - - HTH_1,LysR_substrate k59_1028518_6 933262.AXAM01000001_gene329 7.05e-46 164.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42QP2@68525|delta/epsilon subdivisions,2WN62@28221|Deltaproteobacteria,2MJK0@213118|Desulfobacterales 28221|Deltaproteobacteria T HD domain - - - - - - - - - - - - HD,HD_5 k59_1028518_7 1232683.ADIMK_0084 7.89e-231 659.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,464A6@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_1028518_8 1278309.KB907101_gene752 1.7e-54 175.0 COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria,1S5WY@1236|Gammaproteobacteria,1XMMW@135619|Oceanospirillales 135619|Oceanospirillales Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1028518_9 1198232.CYCME_1033 1.09e-89 311.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,461PB@72273|Thiotrichales 72273|Thiotrichales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF k59_1032178_1 574966.KB898647_gene2637 1.98e-56 184.0 COG3649@1|root,COG3649@2|Bacteria,1MV2A@1224|Proteobacteria,1RPDI@1236|Gammaproteobacteria,1XKSE@135619|Oceanospirillales 135619|Oceanospirillales L Pfam:DUF694 - - - ko:K19118 - - - - ko00000,ko02048 - - - Cas_Cas7 k59_737429_2 556261.HMPREF0240_03061 1.46e-67 218.0 COG0407@1|root,COG0407@2|Bacteria,1USM0@1239|Firmicutes,248G3@186801|Clostridia,36IME@31979|Clostridiaceae 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,URO-D k59_967595_2 1408823.AXUS01000014_gene1288 3.54e-08 55.1 COG3835@1|root,COG3835@2|Bacteria,1TQWD@1239|Firmicutes,24ZMW@186801|Clostridia 186801|Clostridia KT Psort location Cytoplasmic, score - - - ko:K09684 - - - - ko00000,ko03000 - - - HTH_30,PucR k59_771286_1 768671.ThimaDRAFT_1939 1.47e-81 254.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1T5B6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_443688_2 1121405.dsmv_1969 2.23e-41 141.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding crp - 2.7.11.1 ko:K10914,ko:K12132,ko:K21564 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko01000,ko01001,ko03000 - - - cNMP_binding k59_50409_1 344747.PM8797T_29283 3.39e-57 202.0 COG1251@1|root,COG2146@1|root,COG1251@2|Bacteria,COG2146@2|Bacteria,2IY23@203682|Planctomycetes 203682|Planctomycetes C nitrite reductase (NAD(P)H) large subunit - - - - - - - - - - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2 k59_1000614_1 1168034.FH5T_21280 5.03e-78 234.0 COG0757@1|root,COG0757@2|Bacteria,4NNHU@976|Bacteroidetes,2FR57@200643|Bacteroidia 976|Bacteroidetes E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_575675_1 1168034.FH5T_01850 6.8e-119 345.0 COG1076@1|root,COG1076@2|Bacteria,4NF1B@976|Bacteroidetes,2FQ12@200643|Bacteroidia 976|Bacteroidetes O DnaJ domain protein - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_575675_2 1168034.FH5T_01845 5.33e-20 85.9 COG0237@1|root,COG0237@2|Bacteria,4NQKS@976|Bacteroidetes,2FSP8@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_14456_1 945713.IALB_2618 4.38e-130 382.0 COG3033@1|root,COG3033@2|Bacteria 2|Bacteria E tryptophanase activity tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_935181_1 1031288.AXAA01000002_gene1409 2.23e-110 341.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae 186801|Clostridia P Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,Rhodanese k59_737447_1 1121396.KB892935_gene3844 1.36e-13 69.7 COG0535@1|root,COG0535@2|Bacteria,1NDQM@1224|Proteobacteria,42YEG@68525|delta/epsilon subdivisions,2WUNR@28221|Deltaproteobacteria,2MMSQ@213118|Desulfobacterales 28221|Deltaproteobacteria S radical SAM domain protein - - - - - - - - - - - - - k59_313269_1 545264.KB898760_gene2495 5.8e-82 244.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1WXZD@135613|Chromatiales 135613|Chromatiales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_248720_1 1168034.FH5T_15075 4.59e-288 789.0 COG0112@1|root,COG0112@2|Bacteria,4NE30@976|Bacteroidetes,2FM07@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_248720_2 1168034.FH5T_16280 2.74e-26 102.0 COG0302@1|root,COG0302@2|Bacteria,4NFC2@976|Bacteroidetes,2FMYB@200643|Bacteroidia 976|Bacteroidetes H GTP cyclohydrolase folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_837143_1 706587.Desti_0740 9.64e-162 468.0 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42MEY@68525|delta/epsilon subdivisions,2WM0F@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_477206_1 709991.Odosp_0479 2.43e-22 100.0 COG0526@1|root,COG0526@2|Bacteria,4NK6Q@976|Bacteroidetes,2FR0E@200643|Bacteroidia,22ZMS@171551|Porphyromonadaceae 976|Bacteroidetes CO Domain of unknown function (DUF4369) - - - - - - - - - - - - AhpC-TSA,DUF4369 k59_1001186_1 981336.F944_02970 1.33e-26 107.0 COG0438@1|root,COG0438@2|Bacteria,1RKCN@1224|Proteobacteria,1S39F@1236|Gammaproteobacteria,3NKPC@468|Moraxellaceae 1236|Gammaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1001186_2 944547.ABLL_2293 6.41e-116 340.0 COG0726@1|root,COG0726@2|Bacteria,1MZFC@1224|Proteobacteria,42M7D@68525|delta/epsilon subdivisions,2YN0H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1001186_3 553220.CAMGR0001_1937 8.38e-28 109.0 COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,42M2P@68525|delta/epsilon subdivisions,2YNS6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Glycosyltransferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_801036_1 497321.C664_10398 7.76e-136 403.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,2KVS8@206389|Rhodocyclales 206389|Rhodocyclales I AMP-binding enzyme C-terminal domain - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_706603_2 563040.Saut_0956 1.52e-40 141.0 COG2230@1|root,COG2230@2|Bacteria,1QZ24@1224|Proteobacteria,43CEA@68525|delta/epsilon subdivisions,2YTBV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Methionine biosynthesis protein MetW - - - - - - - - - - - - CMAS k59_151991_1 1168034.FH5T_14500 4.6e-96 289.0 COG1559@1|root,COG1559@2|Bacteria,4NG17@976|Bacteroidetes,2FMVX@200643|Bacteroidia 976|Bacteroidetes S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_706605_1 1537917.JU82_10505 4.55e-148 421.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2YM9U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_706605_2 1249480.B649_07215 8.88e-46 154.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2YM8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_641760_2 1279009.ADICEAN_01008 4.03e-45 159.0 COG0508@1|root,COG0508@2|Bacteria,4NF33@976|Bacteroidetes,47K2Z@768503|Cytophagia 976|Bacteroidetes C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_935686_2 870187.Thini_1349 0.000499 42.7 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,46043@72273|Thiotrichales 72273|Thiotrichales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_217136_1 631362.Thi970DRAFT_00760 2.53e-66 214.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,1WX87@135613|Chromatiales 135613|Chromatiales S PFAM Paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA k59_184563_1 572544.Ilyop_0926 9.18e-127 367.0 COG1659@1|root,COG1659@2|Bacteria,379CM@32066|Fusobacteria 32066|Fusobacteria S Encapsulating protein for peroxidase - - - - - - - - - - - - Linocin_M18 k59_184563_2 572544.Ilyop_0925 3.53e-51 164.0 COG3461@1|root,COG3461@2|Bacteria,37AZD@32066|Fusobacteria 32066|Fusobacteria S Evidence 4 Homologs of previously reported genes of - - - ko:K09700 - - - - ko00000 - - - - k59_477227_1 1168034.FH5T_00415 2.68e-105 322.0 COG1934@1|root,COG1934@2|Bacteria,4PKT4@976|Bacteroidetes,2G3HG@200643|Bacteroidia 976|Bacteroidetes S OstA-like protein - - - - - - - - - - - - OstA_2 k59_1001207_1 1165841.SULAR_06038 5.87e-101 311.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2YMEZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thiol disulfide interchange protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7 k59_968073_1 5127.CCT65399 1.38e-50 182.0 2F32K@1|root,2T41I@2759|Eukaryota,38XS5@33154|Opisthokonta,3PXBC@4751|Fungi,3R2SP@4890|Ascomycota,21DSX@147550|Sordariomycetes,3TPAG@5125|Hypocreales,1FVTN@110618|Nectriaceae 4751|Fungi - - - - - - - - - - - - - - - k59_1001210_1 439235.Dalk_1499 5.34e-32 132.0 COG0784@1|root,COG3290@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions 1224|Proteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg k59_50901_1 335543.Sfum_2602 5.38e-55 188.0 COG1488@1|root,COG1488@2|Bacteria,1R5W0@1224|Proteobacteria,42NQQ@68525|delta/epsilon subdivisions,2WJ4V@28221|Deltaproteobacteria,2MQV1@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP - - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase,QRPTase_C k59_184578_1 1005999.GLGR_2796 2.21e-16 87.4 COG2931@1|root,COG3209@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q von willebrand factor, type A - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,VCBS k59_511880_1 864051.BurJ1DRAFT_1916 6.1e-36 123.0 COG2929@1|root,COG2929@2|Bacteria,1PUH1@1224|Proteobacteria,2VWWU@28216|Betaproteobacteria 28216|Betaproteobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_511880_2 946483.Cenrod_2422 3.43e-46 151.0 COG3514@1|root,COG3514@2|Bacteria,1N6IP@1224|Proteobacteria,2VVBD@28216|Betaproteobacteria,4AFFN@80864|Comamonadaceae 28216|Betaproteobacteria S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_477254_1 671143.DAMO_1933 2.24e-57 202.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_511885_1 2340.JV46_03550 3.63e-136 405.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1J4RR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990 Transket_pyr,Transketolase_C,Transketolase_N k59_444254_1 999541.bgla_1g03170 1.65e-56 179.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,1K77S@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_444254_2 314345.SPV1_09809 7.95e-06 48.5 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria 1224|Proteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_348378_1 1408473.JHXO01000001_gene2229 7.95e-76 244.0 COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,2FN9H@200643|Bacteroidia 976|Bacteroidetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_14999_1 765911.Thivi_2200 2.43e-204 580.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WXJT@135613|Chromatiales 135613|Chromatiales F Belongs to the 5'-nucleotidase family - - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_543769_1 1122236.KB905145_gene2421 1.09e-43 150.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,2KKGV@206350|Nitrosomonadales 206350|Nitrosomonadales Q PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_511900_1 1123393.KB891328_gene533 8.98e-64 209.0 COG0475@1|root,COG0475@2|Bacteria,1PK6S@1224|Proteobacteria,2VZ60@28216|Betaproteobacteria,1KTFQ@119069|Hydrogenophilales 119069|Hydrogenophilales P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_968090_1 1123326.JFBL01000012_gene110 3.51e-10 62.8 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2YMZZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Ribonuclease rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB k59_968090_2 709032.Sulku_0674 7.12e-123 362.0 COG1466@1|root,COG1466@2|Bacteria,1RHE9@1224|Proteobacteria,42RI9@68525|delta/epsilon subdivisions,2YP40@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase III - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta k59_968090_4 1537917.JU82_05935 1.75e-60 188.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,42TJR@68525|delta/epsilon subdivisions,2YPZ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_968090_5 929558.SMGD1_1862 2.49e-67 211.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42RN6@68525|delta/epsilon subdivisions,2YP9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_968090_6 1537917.JU82_05945 3.74e-47 152.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2YPHN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_248766_1 1211114.ALIP01000001_gene521 6.91e-25 105.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria,1X432@135614|Xanthomonadales 135614|Xanthomonadales O cytochrome oxidase assembly - - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_279869_1 439235.Dalk_1154 1.16e-24 105.0 COG2221@1|root,COG2221@2|Bacteria 2|Bacteria C Nitrite and sulphite reductase 4Fe-4S - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_10,Fer4_6,Flavodoxin_5,HcyBio,PAPS_reduct k59_152015_1 1280688.AUJB01000015_gene347 1.37e-61 209.0 COG3693@1|root,COG3866@1|root,COG3693@2|Bacteria,COG3866@2|Bacteria,1V17A@1239|Firmicutes,247ZF@186801|Clostridia 186801|Clostridia G Amb_all - - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C,RicinB_lectin_2 k59_801101_2 1262449.CP6013_3057 1.53e-41 145.0 COG1346@1|root,COG1346@2|Bacteria,1TRGN@1239|Firmicutes,24AGM@186801|Clostridia,36HZR@31979|Clostridiaceae 186801|Clostridia M PFAM LrgB family protein lrgB - - - - - - - - - - - LrgB k59_412050_1 472759.Nhal_0092 5.94e-136 416.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_706625_1 1249627.D779_1617 8.06e-14 70.5 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_706625_2 765912.Thimo_3029 2.38e-77 241.0 COG2267@1|root,COG2267@2|Bacteria,1N2R9@1224|Proteobacteria,1T1K8@1236|Gammaproteobacteria,1X2NI@135613|Chromatiales 135613|Chromatiales I The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters bioH - 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_771861_1 999550.KI421507_gene1288 1.14e-27 112.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,2U0K0@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_50917_1 94122.Shewana3_3390 3.27e-63 198.0 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S66I@1236|Gammaproteobacteria,2QBPQ@267890|Shewanellaceae 1236|Gammaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_412056_1 631362.Thi970DRAFT_04871 4.29e-43 150.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWG5@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_641802_1 1121405.dsmv_0105 1.31e-78 247.0 COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria,2MI5R@213118|Desulfobacterales 28221|Deltaproteobacteria P Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto k59_609199_1 376733.IT41_07430 3.74e-41 145.0 COG0607@1|root,COG0607@2|Bacteria,1RDYR@1224|Proteobacteria,2VFYC@28211|Alphaproteobacteria,2PXIU@265|Paracoccus 28211|Alphaproteobacteria M Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_609199_2 1121015.N789_08425 1.06e-56 192.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1X4KT@135614|Xanthomonadales 135614|Xanthomonadales O Among the AAA ATPases, the YifB protease family belongs to the Helix 2 insert clade - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1001237_1 877411.JMMA01000002_gene75 1.56e-19 88.6 COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,3WHZJ@541000|Ruminococcaceae 186801|Clostridia I Hydrolase, alpha beta domain protein - - - - - - - - - - - - Hydrolase_4,Peptidase_S9 k59_1001237_2 272562.CA_C1664 5.76e-31 123.0 COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,36E5W@31979|Clostridiaceae 186801|Clostridia G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_706627_1 757424.Hsero_2587 7.28e-08 59.7 COG2931@1|root,COG3266@1|root,COG2931@2|Bacteria,COG3266@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria 28216|Betaproteobacteria Q PFAM Hemolysin-type calcium-binding cyaA GO:0001906,GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005576,GO:0006873,GO:0006874,GO:0006875,GO:0007204,GO:0008150,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0019725,GO:0019835,GO:0030003,GO:0031640,GO:0035821,GO:0042592,GO:0044179,GO:0044364,GO:0044419,GO:0044764,GO:0048878,GO:0050801,GO:0051480,GO:0051704,GO:0051715,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0072503,GO:0072507,GO:0098771 4.6.1.1 ko:K11005,ko:K11029 ko00230,ko05133,map00230,map05133 M00575 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko02000,ko02042 1.C.11 - - Anthrax_toxA,DUF4214,HCBP_related,He_PIG,HemolysinCabind,RTX k59_379815_1 4572.TRIUR3_00083-P1 3.09e-109 330.0 28Q3A@1|root,2QWRZ@2759|Eukaryota,37IKA@33090|Viridiplantae,3GANT@35493|Streptophyta,3KWRZ@4447|Liliopsida,3IFBD@38820|Poales 35493|Streptophyta J Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns matK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - ko:K20000 - - - - ko00000,ko03016 - - - Intron_maturas2,MatK_N k59_543780_1 1280679.ATVX01000010_gene2289 6.37e-19 93.2 COG5337@1|root,COG5337@2|Bacteria,1U0PJ@1239|Firmicutes,248HG@186801|Clostridia,4BWQG@830|Butyrivibrio 186801|Clostridia M CotH kinase protein - - - - - - - - - - - - CotH k59_118506_1 561180.BIFGAL_03133 1.61e-05 53.9 COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4CYT7@85004|Bifidobacteriales 201174|Actinobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_935729_1 1319815.HMPREF0202_01654 1.48e-86 263.0 COG0581@1|root,COG0581@2|Bacteria,379R4@32066|Fusobacteria 32066|Fusobacteria P Binding-protein-dependent transport system inner membrane component pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_737945_1 1249480.B649_09620 5.57e-132 386.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2YMAS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Small subunit hydA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.5.1 ko:K05927 - - - - ko00000,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_313357_1 1565314.OA34_04985 1.59e-70 235.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2YN9X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_217205_1 187272.Mlg_1950 3.69e-37 132.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1WY8Z@135613|Chromatiales 135613|Chromatiales S Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_313361_1 445971.ANASTE_01068 8.5e-05 50.8 COG3209@1|root,COG4886@1|root,COG3209@2|Bacteria,COG4886@2|Bacteria,1VG11@1239|Firmicutes 1239|Firmicutes M COG3209 Rhs family protein - - - - - - - - - - - - Big_3,SdrD_B k59_85374_2 504472.Slin_0852 2.29e-12 65.1 arCOG09454@1|root,30G4A@2|Bacteria,4NPSB@976|Bacteroidetes,47Q9D@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_549823_1 1150600.ADIARSV_2339 1.41e-25 105.0 COG3064@1|root,COG3064@2|Bacteria 2|Bacteria M translation initiation factor activity - - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - ABC_tran k59_549823_2 1249480.B649_04615 4.06e-08 53.1 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,42N42@68525|delta/epsilon subdivisions,2YMNR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_941676_2 1348635.BBJY01000004_gene3074 1.05e-24 94.4 COG3630@1|root,COG3630@2|Bacteria,1NHYS@1224|Proteobacteria,1SGS8@1236|Gammaproteobacteria,1XZBR@135623|Vibrionales 135623|Vibrionales C Lyase and sodium transporter - GO:0003674,GO:0003824,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008948,GO:0015672,GO:0016829,GO:0016830,GO:0016831,GO:0030001,GO:0051179,GO:0051234 4.1.1.3 ko:K01573 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_gamma k59_518242_2 1168034.FH5T_05580 2.34e-08 54.3 COG1022@1|root,COG1022@2|Bacteria,4NEA4@976|Bacteroidetes,2FNK9@200643|Bacteroidia 976|Bacteroidetes I AMP-binding enzyme fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_647703_1 1056820.KB900640_gene285 2.84e-163 480.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,1RSM7@1236|Gammaproteobacteria,2PQ7K@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_582234_1 1121396.KB893093_gene4423 2.49e-88 290.0 COG0642@1|root,COG4251@1|root,COG0642@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CDW@68525|delta/epsilon subdivisions,2X8IN@28221|Deltaproteobacteria,2MN5R@213118|Desulfobacterales 28221|Deltaproteobacteria T CHASE4 domain - - - - - - - - - - - - CHASE4,HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_1006737_2 883.DvMF_2350 9.07e-28 114.0 COG0642@1|root,COG2199@1|root,COG5000@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,COG5000@2|Bacteria,1NRP8@1224|Proteobacteria,43BMU@68525|delta/epsilon subdivisions,2X6ZW@28221|Deltaproteobacteria,2MH9K@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase with PAS PAC and GAF sensors - - - - - - - - - - - - GGDEF,PAS_3 k59_908112_1 1121403.AUCV01000015_gene4664 6.85e-70 230.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2MIZI@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_647706_1 1304885.AUEY01000018_gene1109 9.58e-40 152.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1006738_1 1168034.FH5T_20565 7.52e-73 243.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_518255_1 1202962.KB907150_gene1881 1.04e-61 210.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Acyltransferase ws dgat mgat - - - - - - - - - - - - DUF1298,WES_acyltransf k59_386070_1 671143.DAMO_2489 9.54e-109 336.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain xpsE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_124452_1 981384.AEYW01000018_gene3284 2.46e-159 484.0 COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,2TTSD@28211|Alphaproteobacteria,4NCZM@97050|Ruegeria 28211|Alphaproteobacteria L RNase_H superfamily - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,RNase_H_2 k59_386073_1 886379.AEWI01000012_gene1175 7.8e-34 127.0 COG0810@1|root,COG0810@2|Bacteria,4NMG7@976|Bacteroidetes,2FPKW@200643|Bacteroidia,3XJWP@558415|Marinilabiliaceae 976|Bacteroidetes M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_386074_1 1201293.AKXQ01000001_gene2036 1.4e-54 197.0 COG0834@1|root,COG2202@1|root,COG4585@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4585@2|Bacteria,1NWNJ@1224|Proteobacteria 1224|Proteobacteria T PAS domain containing protein - - - - - - - - - - - - EAL,GGDEF,HATPase_c,HTH_3,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3 k59_777594_2 572544.Ilyop_1358 2e-62 199.0 COG0206@1|root,COG0206@2|Bacteria,378TM@32066|Fusobacteria 32066|Fusobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity - - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_91757_1 387093.SUN_0047 2.77e-46 165.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42NYV@68525|delta/epsilon subdivisions,2YN1D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_842678_1 1163617.SCD_n00183 1.41e-81 252.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria 28216|Betaproteobacteria P Phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_285872_1 879212.DespoDRAFT_01479 2.85e-196 552.0 COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,42VIF@68525|delta/epsilon subdivisions,2WRY1@28221|Deltaproteobacteria,2MQ11@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_908144_1 696281.Desru_0587 1.04e-110 323.0 COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,264AC@186807|Peptococcaceae 186801|Clostridia P ATPases associated with a variety of cellular activities - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_417398_2 240016.ABIZ01000001_gene1257 6.74e-44 151.0 COG0020@1|root,COG0020@2|Bacteria,46SMY@74201|Verrucomicrobia,2IU5V@203494|Verrucomicrobiae 203494|Verrucomicrobiae I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids - - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_743583_2 107636.JQNK01000002_gene94 5.15e-34 127.0 COG3598@1|root,COG3598@2|Bacteria,1R4GJ@1224|Proteobacteria 1224|Proteobacteria L AAA domain - - - - - - - - - - - - AAA_25,Prim-Pol k59_386101_1 933262.AXAM01000027_gene2092 1.71e-58 193.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,2MHWG@213118|Desulfobacterales 28221|Deltaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_285874_1 322710.Avin_50730 6.92e-35 129.0 COG0725@1|root,COG0725@2|Bacteria,1MX18@1224|Proteobacteria,1T1E0@1236|Gammaproteobacteria 1236|Gammaproteobacteria P TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_285874_2 177437.HRM2_01670 8.63e-60 204.0 COG3203@1|root,COG3203@2|Bacteria,1Q1EE@1224|Proteobacteria,42VWQ@68525|delta/epsilon subdivisions,2X28W@28221|Deltaproteobacteria,2MP2R@213118|Desulfobacterales 28221|Deltaproteobacteria M Alginate export - - - - - - - - - - - - Alginate_exp k59_450709_2 338963.Pcar_0275 4.81e-17 84.3 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,43UAH@69541|Desulfuromonadales 28221|Deltaproteobacteria E Peptidase dimerisation domain argE - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_158567_1 1121405.dsmv_3191 4.96e-21 87.8 COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,42U9S@68525|delta/epsilon subdivisions,2WQ1X@28221|Deltaproteobacteria,2MK54@213118|Desulfobacterales 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF882) ycbK - - - - - - - - - - - Peptidase_M15_2 k59_158567_2 1121405.dsmv_1167 1.49e-29 107.0 COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,42VFI@68525|delta/epsilon subdivisions,2WR7C@28221|Deltaproteobacteria,2MNWC@213118|Desulfobacterales 28221|Deltaproteobacteria S Cupin domain - - - ko:K11312 - - - - ko00000 - - - Cupin_2 k59_712366_1 392500.Swoo_3150 5.75e-05 53.5 COG3210@1|root,COG3637@1|root,COG4733@1|root,COG4886@1|root,COG3210@2|Bacteria,COG3637@2|Bacteria,COG4733@2|Bacteria,COG4886@2|Bacteria,1QUXB@1224|Proteobacteria,1T32K@1236|Gammaproteobacteria 1236|Gammaproteobacteria U HemY domain protein - - - - - - - - - - - - Big_5,Cadherin_3,Calx-beta,DUF4347,He_PIG,OmpA_membrane k59_549871_1 827.JFJK01000015_gene416 4.36e-11 65.9 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_549871_2 760154.Sulba_1666 7.44e-19 85.5 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_908147_1 1121405.dsmv_1591 6.42e-57 188.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MIF1@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_842695_1 572477.Alvin_1848 1.83e-133 388.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria,1WWRP@135613|Chromatiales 135613|Chromatiales C Isocitrate lyase - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_386107_1 1121403.AUCV01000018_gene3220 8.42e-262 728.0 COG5421@1|root,COG5421@2|Bacteria,1R8EJ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - DDE_Tnp_1 k59_1006781_1 1454010.JEOE01000057_gene984 4.34e-46 178.0 arCOG08054@1|root,2Z8AD@2|Bacteria,2GKIT@201174|Actinobacteria,4F0EE@85016|Cellulomonadaceae 201174|Actinobacteria S Carbohydrate-binding domain-containing protein Cthe_2159 - - - - - - - - - - - - Cthe_2159 k59_1039022_1 1168034.FH5T_08740 2.18e-66 219.0 COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,4NKCK@976|Bacteroidetes,2G172@200643|Bacteroidia 976|Bacteroidetes M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT,TPR_16,TPR_19,TPR_8 k59_450728_1 469617.FUAG_01605 2.11e-30 116.0 COG0457@1|root,COG0457@2|Bacteria,379QP@32066|Fusobacteria 32066|Fusobacteria S TPR repeat - - - - - - - - - - - - TPR_19,TPR_8 k59_353948_1 399795.CtesDRAFT_PD2176 2.89e-47 157.0 2E0HJ@1|root,32W3D@2|Bacteria,1N10N@1224|Proteobacteria,2W46X@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_353948_2 666681.M301_1016 0.0009 40.0 2E103@1|root,32WG8@2|Bacteria,1N3U5@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1039035_1 998674.ATTE01000001_gene1045 5.34e-84 254.0 COG0500@1|root,COG0500@2|Bacteria,1QVF3@1224|Proteobacteria,1T2D6@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methyl-transferase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_91809_1 1158292.JPOE01000005_gene1144 3.02e-61 200.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1KKHM@119065|unclassified Burkholderiales 28216|Betaproteobacteria K LysR substrate binding domain - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_21013_1 1408473.JHXO01000004_gene106 2.04e-68 215.0 COG4974@1|root,COG4974@2|Bacteria,4NE0E@976|Bacteroidetes,2FP3B@200643|Bacteroidia 976|Bacteroidetes D tyrosine recombinase XerC xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_21013_2 391598.FBBAL38_06525 5.04e-06 47.8 COG1866@1|root,COG1866@2|Bacteria,4NEGI@976|Bacteroidetes,1HX6C@117743|Flavobacteriia 976|Bacteroidetes H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_124528_1 1168034.FH5T_15060 2.37e-46 161.0 COG0119@1|root,COG0119@2|Bacteria,4NEIT@976|Bacteroidetes,2FNX8@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_806856_1 1304275.C41B8_15330 1.29e-99 303.0 COG3755@1|root,COG3755@2|Bacteria,1NJ7S@1224|Proteobacteria,1SP8U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pfam:DUF1311 - - - - - - - - - - - - LprI k59_941780_1 1168034.FH5T_15280 5.23e-84 257.0 COG0524@1|root,COG0524@2|Bacteria,4NFH8@976|Bacteroidetes,2FMY2@200643|Bacteroidia 976|Bacteroidetes G Kinase, PfkB family - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_941780_2 1168034.FH5T_15285 3.63e-05 44.7 COG0800@1|root,COG0800@2|Bacteria,4NEFY@976|Bacteroidetes,2FNWD@200643|Bacteroidia 976|Bacteroidetes G KDPG and KHG aldolase eda - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_550606_1 1249627.D779_3815 1.21e-73 238.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_418219_1 1123073.KB899241_gene3293 3.73e-10 62.8 COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,1S0KD@1236|Gammaproteobacteria,1X3ST@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_418219_2 1050201.KB913034_gene210 2.65e-14 71.6 COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,3VP0J@526524|Erysipelotrichia 526524|Erysipelotrichia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_843432_1 749222.Nitsa_0387 2.95e-110 332.0 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2YMQS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_286924_2 1215092.PA6_016_01500 1.03e-30 114.0 COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,1S4K8@1236|Gammaproteobacteria,1YD9Q@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria Q DSBA-like thioredoxin domain - - 5.99.1.4 ko:K14584 ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220 M00534 R05137 RC03084 br01602,ko00000,ko00001,ko00002,ko01000 - - - DSBA k59_1039830_1 1217712.F971_00797 2.68e-26 105.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,3NIR4@468|Moraxellaceae 1236|Gammaproteobacteria I Fatty acid desaturase desC - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_1039830_2 1298593.TOL_2070 1.33e-21 93.2 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,1XIKA@135619|Oceanospirillales 135619|Oceanospirillales I Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_387016_1 1168034.FH5T_15435 1.79e-64 201.0 COG1595@1|root,COG1595@2|Bacteria,4NF93@976|Bacteroidetes,2FNJV@200643|Bacteroidia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_57710_1 338963.Pcar_2866 9.96e-128 376.0 COG3303@1|root,COG3303@2|Bacteria,1MVJT@1224|Proteobacteria,42MPU@68525|delta/epsilon subdivisions,2WIJ1@28221|Deltaproteobacteria,43UNQ@69541|Desulfuromonadales 28221|Deltaproteobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process nrfA - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 k59_974397_1 28229.ND2E_2935 2.85e-50 176.0 COG0654@1|root,COG0654@2|Bacteria,1P0KU@1224|Proteobacteria,1RPHM@1236|Gammaproteobacteria,2Q7UD@267889|Colwelliaceae 1236|Gammaproteobacteria CH FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_974397_2 1165841.SULAR_01768 1.43e-27 105.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2YP4X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L methyltransferase rsmD - - - - - - - - - - - Cons_hypoth95 k59_713220_1 314345.SPV1_10591 2.27e-177 523.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria 1224|Proteobacteria P Heavy metal translocating P-type atpase copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_843440_1 1355374.JARU01000001_gene559 8.71e-11 63.5 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2YN4S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_843440_2 1537917.JU82_00490 2.35e-52 181.0 COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2YMJN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,RMMBL k59_319609_1 1269813.ATUL01000004_gene2251 1.37e-06 48.5 COG0594@1|root,COG0594@2|Bacteria 2|Bacteria J ribonuclease P activity rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_319609_2 765914.ThisiDRAFT_0270 2.48e-18 85.9 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales 135613|Chromatiales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_778586_1 1168034.FH5T_04685 1.88e-114 360.0 COG5000@1|root,COG5000@2|Bacteria,4NE49@976|Bacteroidetes,2FRVJ@200643|Bacteroidia 976|Bacteroidetes T COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation zraS_1 - - - - - - - - - - - HATPase_c,HisKA k59_974405_1 1168034.FH5T_10240 8.97e-76 232.0 COG0704@1|root,COG0704@2|Bacteria,4NQ6U@976|Bacteroidetes,2G3C4@200643|Bacteroidia 976|Bacteroidetes P PhoU domain - - - ko:K02039 - - - - ko00000 - - - PhoU k59_583076_1 1537917.JU82_07175 1.82e-81 269.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2YMA1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_778587_2 225937.HP15_2124 3.5e-15 76.6 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,46411@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_159492_2 936574.HMPREF1508_1646 4.35e-25 104.0 COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia 186801|Clostridia G phosphoglycerate mutase apgM - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_286958_1 471870.BACINT_01234 1.99e-79 268.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,2FM8X@200643|Bacteroidia,4AKN4@815|Bacteroidaceae 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_550651_1 1168034.FH5T_01365 1.26e-108 332.0 COG0488@1|root,COG0488@2|Bacteria,4NG1W@976|Bacteroidetes,2FMY5@200643|Bacteroidia 976|Bacteroidetes S ABC transporter, ATP-binding protein yheS_3 - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_57741_1 582899.Hden_2551 5.26e-35 135.0 COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,2TRM3@28211|Alphaproteobacteria,3N6ST@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_1039853_1 412965.COSY_0434 2.05e-41 149.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1J4JQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1039853_3 1121428.DESHY_110166___1 1.4e-07 55.5 COG0342@1|root,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,260H2@186807|Peptococcaceae 186801|Clostridia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_550655_1 1211114.ALIP01000034_gene1875 3.71e-32 120.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1X3PJ@135614|Xanthomonadales 135614|Xanthomonadales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_550655_2 305700.B447_05228 1.4e-09 61.6 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,2KUV5@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_125224_2 749222.Nitsa_0960 2.3e-150 451.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNMM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.6,3.6.3.8 ko:K01535,ko:K01537 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.2,3.A.3.3 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_61850_1 1073754.G0ZND4_9VIRU 1.18e-36 138.0 4QGM3@10239|Viruses 10239|Viruses S oxidoreductase activity - - - - - - - - - - - - - k59_61850_2 926692.AZYG01000059_gene70 3.14e-32 122.0 COG2963@1|root,COG2963@2|Bacteria,1V6XW@1239|Firmicutes,24K7P@186801|Clostridia 186801|Clostridia L HNH endonuclease - - - - - - - - - - - - HTH_23,HTH_Tnp_1 k59_879956_1 492774.JQMB01000020_gene3632 1.87e-41 154.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase cyaF2 - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8 k59_912930_1 1121887.AUDK01000004_gene348 2.26e-62 206.0 COG3174@1|root,COG3174@2|Bacteria,4NKP6@976|Bacteroidetes,1HYVZ@117743|Flavobacteriia,2NWZW@237|Flavobacterium 976|Bacteroidetes S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_195715_1 794903.OPIT5_16565 1.44e-20 83.6 COG5450@1|root,COG5450@2|Bacteria 2|Bacteria K positive regulation of growth - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - - - - - - - - - - VapB_antitoxin k59_947316_2 1123256.KB907932_gene2966 1.18e-21 92.8 COG5430@1|root,COG5430@2|Bacteria,1RM0N@1224|Proteobacteria,1SCED@1236|Gammaproteobacteria,1X854@135614|Xanthomonadales 135614|Xanthomonadales S Spore Coat Protein U domain - - - - - - - - - - - - SCPU k59_847935_1 683083.C414_000160026 1.72e-12 68.2 COG3843@1|root,COG3843@2|Bacteria,1MVHF@1224|Proteobacteria,42R02@68525|delta/epsilon subdivisions,2YNXA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U relaxase - - - - - - - - - - - - Relaxase k59_62268_1 572544.Ilyop_0585 6.39e-101 301.0 COG1077@1|root,COG1077@2|Bacteria,378FF@32066|Fusobacteria 32066|Fusobacteria D cell shape determining protein, MreB Mrl mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_291228_1 553217.ENHAE0001_2020 8.89e-49 166.0 COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria,1S6M1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane transporter protein - - - - - - - - - - - - TauE k59_291228_2 382245.ASA_3090 2.31e-09 58.5 COG0303@1|root,COG1763@1|root,COG0303@2|Bacteria,COG1763@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1Y445@135624|Aeromonadales 135624|Aeromonadales H MoeA N-terminal region (domain I and II) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MobB,MoeA_C,MoeA_N k59_96714_1 2002.JOEQ01000028_gene8089 1.75e-05 52.4 COG1309@1|root,COG1309@2|Bacteria,2IBZK@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_96714_2 1408423.JHYA01000015_gene578 1.86e-38 141.0 COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4H20G@909932|Negativicutes 909932|Negativicutes H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_587808_1 1384056.N787_04325 1.38e-09 58.5 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1X4XB@135614|Xanthomonadales 135614|Xanthomonadales NU assembly protein (PilN) pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_587808_2 1049564.TevJSym_bb00160 7.39e-82 249.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_487816_1 1123240.ATVO01000006_gene1451 2.03e-27 112.0 COG3258@1|root,COG3258@2|Bacteria,1NIQK@1224|Proteobacteria,2U0YV@28211|Alphaproteobacteria,2K22P@204457|Sphingomonadales 204457|Sphingomonadales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_812613_1 743721.Psesu_0805 1.67e-109 330.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1X3MI@135614|Xanthomonadales 135614|Xanthomonadales S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_587819_1 1392489.JPOL01000003_gene303 8.06e-31 113.0 2DEYG@1|root,2ZPSM@2|Bacteria,4NNJW@976|Bacteroidetes,1I1XW@117743|Flavobacteriia,2XJBZ@283735|Leeuwenhoekiella 976|Bacteroidetes - - - - - - - - - - - - - - - k59_260045_1 709032.Sulku_1042 6.08e-151 449.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2YMT6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_913627_1 1349767.GJA_2267 5.5e-23 98.2 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,472TR@75682|Oxalobacteraceae 28216|Betaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_422845_1 1168034.FH5T_13675 4.78e-33 122.0 COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,2FNXM@200643|Bacteroidia 976|Bacteroidetes S Von Willebrand factor type A domain batA - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA k59_422845_2 1168034.FH5T_13680 1.97e-62 202.0 COG3088@1|root,COG3088@2|Bacteria,4NGHU@976|Bacteroidetes,2FP8Y@200643|Bacteroidia 976|Bacteroidetes O Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - k59_620688_1 373903.Hore_03240 3.78e-99 297.0 COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,3WBQI@53433|Halanaerobiales 186801|Clostridia C TIGRFAM 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase - - 1.1.1.303,1.1.1.4 ko:K00004 ko00650,map00650 - R02855,R02946,R10504 RC00205,RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_847950_1 1286106.MPL1_03353 2.03e-100 311.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,45ZQH@72273|Thiotrichales 72273|Thiotrichales E peptidase - - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_324235_1 1249627.D779_3272 4.35e-15 74.3 2C8T8@1|root,32RMU@2|Bacteria,1N089@1224|Proteobacteria,1SAT4@1236|Gammaproteobacteria,1WYU4@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_324235_2 1123514.KB905900_gene2089 2.23e-62 216.0 COG0526@1|root,COG0526@2|Bacteria,1RCTX@1224|Proteobacteria,1S4XW@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO Thioredoxin resA - - - - - - - - - - - AhpC-TSA,Redoxin k59_324235_3 631362.Thi970DRAFT_04464 2.77e-34 129.0 292F7@1|root,2ZPZF@2|Bacteria,1RGFI@1224|Proteobacteria,1S48P@1236|Gammaproteobacteria,1WY8A@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_913654_1 572544.Ilyop_0512 1.72e-104 307.0 COG0368@1|root,COG0368@2|Bacteria,379H2@32066|Fusobacteria 32066|Fusobacteria H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_913654_2 572544.Ilyop_0511 1.72e-17 77.8 COG2087@1|root,COG2087@2|Bacteria,37A1F@32066|Fusobacteria 32066|Fusobacteria H Adenosylcobinamide kinase adenosylcobinamide-phosphate guanylyltransferase cobU - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU k59_812645_2 709032.Sulku_2303 5.87e-81 246.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2YMYB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_587861_1 237368.SCABRO_01747 5.05e-55 182.0 COG1943@1|root,COG1943@2|Bacteria,2J13K@203682|Planctomycetes 203682|Planctomycetes L Transposase IS200 like - - - - - - - - - - - - - k59_913660_2 1408473.JHXO01000010_gene3537 2.04e-32 117.0 COG2852@1|root,COG2852@2|Bacteria,4NUSE@976|Bacteroidetes,2FUH5@200643|Bacteroidia 976|Bacteroidetes S Protein of unknown function (DUF559) - - - - - - - - - - - - DUF559 k59_913660_3 1168034.FH5T_21420 3.34e-56 186.0 COG3206@1|root,COG3206@2|Bacteria,4NJJY@976|Bacteroidetes,2FKZI@200643|Bacteroidia 976|Bacteroidetes M Chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_324237_1 1319815.HMPREF0202_00634 3.68e-151 456.0 COG0458@1|root,COG0458@2|Bacteria,378K3@32066|Fusobacteria 32066|Fusobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_324237_2 526218.Sterm_2670 1.73e-187 528.0 COG0505@1|root,COG0505@2|Bacteria,378K8@32066|Fusobacteria 32066|Fusobacteria F Belongs to the CarA family carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_324237_5 1408439.JHXW01000015_gene1736 1.27e-192 548.0 COG2759@1|root,COG2759@2|Bacteria,37930@32066|Fusobacteria 32066|Fusobacteria H Formyltetrahydrofolate synthetase fhs GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_487867_1 69328.PVLB_16290 1.29e-87 270.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_129927_2 1223410.KN050846_gene435 5.26e-26 99.4 2E695@1|root,330X7@2|Bacteria,4NVE0@976|Bacteroidetes,1I53C@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_129927_3 1250278.JQNQ01000001_gene466 1.44e-16 73.2 COG3027@1|root,COG3027@2|Bacteria,4NSA5@976|Bacteroidetes,1I41M@117743|Flavobacteriia 976|Bacteroidetes D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division zapA - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_587874_2 717772.THIAE_04360 8.5e-71 222.0 COG0463@1|root,COG0463@2|Bacteria,1RGMI@1224|Proteobacteria,1S525@1236|Gammaproteobacteria,4618G@72273|Thiotrichales 72273|Thiotrichales M transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_812662_1 1499967.BAYZ01000174_gene5829 2.67e-67 223.0 COG0407@1|root,COG0407@2|Bacteria 2|Bacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - Thioredoxin_3,URO-D k59_291301_1 941449.dsx2_3128 6.49e-37 130.0 296ZZ@1|root,2ZU8H@2|Bacteria,1RED2@1224|Proteobacteria,42RDU@68525|delta/epsilon subdivisions,2WPHV@28221|Deltaproteobacteria,2MB4Z@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_291301_2 749222.Nitsa_0963 2.13e-12 68.6 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2YNV5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1012074_1 709032.Sulku_1290 4.8e-33 130.0 COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42YBF@68525|delta/epsilon subdivisions,2YRIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF k59_812669_2 1408422.JHYF01000004_gene1578 5.2e-05 45.8 COG0546@1|root,COG0546@2|Bacteria,1V34Q@1239|Firmicutes,24K6V@186801|Clostridia 186801|Clostridia S TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1044415_1 945713.IALB_2888 2.15e-06 57.8 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process rfbX - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_228542_1 1191523.MROS_0630 2.93e-18 77.4 2EGD6@1|root,33A4Z@2|Bacteria 2|Bacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_652736_1 685035.ADAE01000004_gene1931 1.2e-53 182.0 COG1226@1|root,COG1226@2|Bacteria,1MXQP@1224|Proteobacteria,2TTRN@28211|Alphaproteobacteria,2K11P@204457|Sphingomonadales 204457|Sphingomonadales P COG1226 Kef-type K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_N k59_880662_1 1415779.JOMH01000001_gene2597 4.96e-77 244.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1X2ZV@135614|Xanthomonadales 135614|Xanthomonadales M Lipoprotein releasing system transmembrane protein lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_422896_1 1265313.HRUBRA_01484 4.81e-70 224.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1J4YI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Predicted permease YjgP/YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_812697_1 396588.Tgr7_0643 1.44e-30 112.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_812697_2 396588.Tgr7_0573 6.37e-76 239.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M20A family. ArgE subfamily - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_62322_1 118168.MC7420_1742 2.49e-37 137.0 COG3217@1|root,COG3217@2|Bacteria,1G41J@1117|Cyanobacteria,1HA5C@1150|Oscillatoriales 1117|Cyanobacteria S Fe-S protein - - - ko:K07140 - - - - ko00000 - - - MOSC,MOSC_N k59_359374_1 572544.Ilyop_0472 6.09e-166 477.0 COG2508@1|root,COG2508@2|Bacteria 2|Bacteria QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30,PucR k59_812713_1 187272.Mlg_1800 7.67e-111 350.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_260128_1 690850.Desaf_0239 1.45e-34 130.0 arCOG06116@1|root,30C51@2|Bacteria,1REWK@1224|Proteobacteria,42RFM@68525|delta/epsilon subdivisions,2WNYX@28221|Deltaproteobacteria,2MBHZ@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_848014_1 1165841.SULAR_03597 1.72e-93 296.0 COG1251@1|root,COG1740@1|root,COG1251@2|Bacteria,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42PSD@68525|delta/epsilon subdivisions,2YNBA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C hydrogenase (NiFe) small subunit HydA - - 1.12.5.1 ko:K05927 - - - - ko00000,ko01000 - - - Fer2_BFD,NiFe_hyd_SSU_C,Oxidored_q6,Pyr_redox_2 k59_487948_1 1150621.SMUL_2316 8.26e-43 144.0 297UU@1|root,2ZCNK@2|Bacteria,1RB5C@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_487948_2 1215092.PA6_028_00120 1.33e-32 120.0 COG1988@1|root,COG1988@2|Bacteria,1RBHW@1224|Proteobacteria,1S2F9@1236|Gammaproteobacteria,1YGC1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S LexA-binding, inner membrane-associated putative hydrolase ybcI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07038 - - - - ko00000 - - - YdjM k59_96834_1 1121935.AQXX01000105_gene327 6.02e-85 266.0 COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria,1XH8F@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the degradation of histidine to urocanate and ammmonia hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_422922_1 243365.CV_2498 2.72e-26 114.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KSG8@206351|Neisseriales 206351|Neisseriales T Hpt domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_1044444_1 1280689.AUJC01000001_gene2402 2.66e-07 53.1 COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,36DUM@31979|Clostridiaceae 186801|Clostridia J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1044444_2 138119.DSY2269 9.78e-79 256.0 COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,2607U@186807|Peptococcaceae 186801|Clostridia S HI0933 family - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_652768_1 980584.AFPB01000068_gene1399 2e-15 75.1 COG2070@1|root,COG2070@2|Bacteria,4NEGW@976|Bacteroidetes,1HZ2A@117743|Flavobacteriia,406TC@61432|unclassified Flavobacteriaceae 976|Bacteroidetes S 2-Nitropropane dioxygenase - - - - - - - - - - - - - k59_359391_1 1122176.KB903609_gene5176 3.77e-45 166.0 COG0550@1|root,COG0550@2|Bacteria,4NF9S@976|Bacteroidetes,1IPJD@117747|Sphingobacteriia 976|Bacteroidetes L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt k59_880693_1 65497.JODV01000011_gene2448 2.2e-63 219.0 COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4DYSA@85010|Pseudonocardiales 201174|Actinobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_359396_1 1453498.LG45_14015 1.82e-15 81.6 COG1572@1|root,COG2911@1|root,COG3291@1|root,COG1572@2|Bacteria,COG2911@2|Bacteria,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia,2NS7P@237|Flavobacterium 976|Bacteroidetes S C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,HYR,SprB,fn3 k59_324350_1 1249480.B649_07215 2.17e-23 95.5 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2YM8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_324350_2 929558.SMGD1_2752 2.55e-101 299.0 COG1994@1|root,COG1994@2|Bacteria,1N531@1224|Proteobacteria,43AZN@68525|delta/epsilon subdivisions,2YP0U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_880698_2 1459636.NTE_03552 9.91e-07 50.8 COG0123@1|root,arCOG00324@2157|Archaea 2157|Archaea BQ including yeast histone deacetylase and acetoin utilization protein - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_587974_1 1049564.TevJSym_ag00550 1.83e-28 105.0 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SD3Y@1236|Gammaproteobacteria,1J6YA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_228566_1 1121015.N789_08285 2.03e-161 470.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X9T5@135614|Xanthomonadales 135614|Xanthomonadales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_620788_1 439235.Dalk_2833 3.97e-82 253.0 COG0247@1|root,COG0247@2|Bacteria,1R8K1@1224|Proteobacteria,42MRC@68525|delta/epsilon subdivisions,2WMEA@28221|Deltaproteobacteria,2MN2E@213118|Desulfobacterales 28221|Deltaproteobacteria C Cysteine-rich domain - - - - - - - - - - - - CCG k59_359405_1 373994.Riv7116_2822 8.59e-47 166.0 COG3572@1|root,COG3572@2|Bacteria 2|Bacteria H ergothioneine biosynthetic process - - 6.3.2.2 ko:K01919,ko:K06048 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GCS2 k59_359406_1 1121438.JNJA01000005_gene1183 7.37e-45 160.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42PGM@68525|delta/epsilon subdivisions,2X5J8@28221|Deltaproteobacteria,2MGRT@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_422945_1 572477.Alvin_1244 4.72e-28 114.0 COG0639@1|root,COG0639@2|Bacteria,1R5DR@1224|Proteobacteria,1RS9W@1236|Gammaproteobacteria,1WXS1@135613|Chromatiales 135613|Chromatiales T Protein phosphatase 2A homologues, catalytic domain. - - - - - - - - - - - - Metallophos k59_812762_1 1123393.KB891326_gene99 8.36e-101 302.0 COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_947408_1 749222.Nitsa_1056 9.47e-192 537.0 COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,42NHJ@68525|delta/epsilon subdivisions,2YNDV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k59_722534_1 720555.BATR1942_06395 2.49e-37 144.0 COG0300@1|root,COG0318@1|root,COG1020@1|root,COG1028@1|root,COG3321@1|root,COG0300@2|Bacteria,COG0318@2|Bacteria,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HTBC@91061|Bacilli,1ZS7J@1386|Bacillus 91061|Bacilli IQ polyketide synthase - - - ko:K13611,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_885624_1 1121405.dsmv_2975 7.45e-101 305.0 COG0034@1|root,COG0034@2|Bacteria,1R7JX@1224|Proteobacteria,42MAC@68525|delta/epsilon subdivisions,2WKFD@28221|Deltaproteobacteria,2MIUW@213118|Desulfobacterales 28221|Deltaproteobacteria F Glutamine amidotransferase domain - - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7 k59_951606_2 926561.KB900617_gene1320 1.63e-96 314.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3WBD0@53433|Halanaerobiales 186801|Clostridia E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_297452_1 493475.GARC_1929 1.01e-127 375.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,464W8@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_199384_1 985867.AEWF01000004_gene222 1.24e-223 636.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,47FZ6@766|Rickettsiales 766|Rickettsiales I Acyl-CoA dehydrogenase N terminal - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_199384_2 1267005.KB911260_gene3479 6.68e-31 117.0 COG0824@1|root,COG0824@2|Bacteria,1RCSP@1224|Proteobacteria,2U6RM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Thioesterase-like superfamily - - - - - - - - - - - - 4HBT_2 k59_199384_3 1528106.JRJE01000005_gene1361 3.91e-127 367.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,2JPSB@204441|Rhodospirillales 204441|Rhodospirillales C Electron transfer flavoprotein, beta subunit etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_199384_4 557598.LHK_02912 1.98e-138 400.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,2KQB3@206351|Neisseriales 206351|Neisseriales C electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_199384_5 557598.LHK_02892 3e-277 771.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,2KPZB@206351|Neisseriales 206351|Neisseriales C FAD dependent oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_199384_6 1232683.ADIMK_2527 9.41e-166 473.0 COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,1RQ8P@1236|Gammaproteobacteria,466QB@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG2207 AraC-type DNA-binding domain-containing proteins - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_199384_7 1049564.TevJSym_ax00460 7.54e-29 105.0 2EPYJ@1|root,33HJ5@2|Bacteria,1NGGR@1224|Proteobacteria,1SI73@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_199384_8 207954.MED92_08336 7.99e-73 226.0 COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,1S8AC@1236|Gammaproteobacteria,1XJHZ@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - TetR_N,WHG k59_199384_9 998674.ATTE01000001_gene2388 1.05e-123 361.0 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,1RPGI@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_199384_10 207954.MED92_08346 0.0 958.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1XIDU@135619|Oceanospirillales 135619|Oceanospirillales C Catalyzes the formation of trans-2- enoyl-CoA from 2,4-dienoyl-CoA fadH - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_199384_11 1121374.KB891575_gene1377 5.9e-165 471.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_983933_1 1537917.JU82_06160 6.54e-74 224.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,42SI7@68525|delta/epsilon subdivisions,2YP7Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0178 family - - - ko:K09768 - - - - ko00000 - - - DUF188 k59_395758_1 224911.27351073 1.19e-126 377.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3JQU8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde dehydrogenase family MA20_17005 - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_853426_1 498211.CJA_3678 9.72e-49 182.0 COG3299@1|root,COG3299@2|Bacteria,1MY5J@1224|Proteobacteria,1S324@1236|Gammaproteobacteria,1FHWW@10|Cellvibrio 1236|Gammaproteobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_624526_1 398767.Glov_1392 3.24e-72 243.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales 28221|Deltaproteobacteria V TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_526714_1 396588.Tgr7_0198 4.85e-28 110.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_526714_2 765910.MARPU_04185 5.54e-22 99.8 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_167262_1 264198.Reut_A0380 2.44e-69 224.0 COG2207@1|root,COG2207@2|Bacteria,1RH01@1224|Proteobacteria,2VQ3J@28216|Betaproteobacteria,1JZTI@119060|Burkholderiaceae 28216|Betaproteobacteria K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_167262_2 247490.KSU1_C1449 1.41e-09 57.8 28HMZ@1|root,2Z7WD@2|Bacteria,2J2EK@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_35743_1 269796.Rru_A1449 2.79e-61 199.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2TSVJ@28211|Alphaproteobacteria,2JQSA@204441|Rhodospirillales 204441|Rhodospirillales P COG0798 Arsenite efflux pump ACR3 and related permeases - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_493918_1 1200792.AKYF01000017_gene5565 5.27e-90 295.0 COG0236@1|root,COG1028@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins pksL - - ko:K13613 - - - - ko00000,ko01004,ko01008 - - - ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_624527_1 398512.JQKC01000033_gene5010 8.69e-107 343.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3WHE2@541000|Ruminococcaceae 186801|Clostridia E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_101693_2 1089550.ATTH01000001_gene2120 3.41e-24 109.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,1FIWT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Pyruvate:ferredoxin oxidoreductase core domain II porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_722541_1 556268.OFAG_00847 4.08e-87 267.0 COG0338@1|root,COG0338@2|Bacteria,1P85S@1224|Proteobacteria,2VNFF@28216|Betaproteobacteria 28216|Betaproteobacteria L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_722541_2 1121930.AQXG01000001_gene1631 3.73e-43 144.0 2EF8R@1|root,32W7B@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_395767_2 1537917.JU82_05570 2.06e-40 149.0 COG1629@1|root,COG4771@2|Bacteria,1MXY7@1224|Proteobacteria,42MSN@68525|delta/epsilon subdivisions,2YN7D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_461454_1 215803.DB30_7377 2.86e-23 105.0 COG3281@1|root,COG3281@2|Bacteria,1NWMM@1224|Proteobacteria,43741@68525|delta/epsilon subdivisions,2X1YE@28221|Deltaproteobacteria,2YX62@29|Myxococcales 28221|Deltaproteobacteria G Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_101703_1 323261.Noc_2673 2.43e-71 222.0 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_690000_2 768066.HELO_3775 3.14e-11 60.8 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1XM7C@135619|Oceanospirillales 135619|Oceanospirillales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_690000_3 1384054.N790_05025 3.03e-54 175.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1X6FE@135614|Xanthomonadales 135614|Xanthomonadales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_297472_1 696369.KI912183_gene1198 5.37e-05 42.0 2CEAQ@1|root,33N8U@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_297472_2 196164.23493383 1.12e-07 57.4 29WRJ@1|root,30ICM@2|Bacteria,2H09C@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_330627_1 468059.AUHA01000003_gene1835 9.34e-107 348.0 COG1404@1|root,COG1404@2|Bacteria,4NHSQ@976|Bacteroidetes,1IWJ1@117747|Sphingobacteriia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_722550_1 1283300.ATXB01000001_gene2009 7.47e-80 249.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1XEE2@135618|Methylococcales 135618|Methylococcales NU TIGRFAM Pilus retraction protein PilT - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_657713_1 1168034.FH5T_10230 3.31e-82 251.0 COG0581@1|root,COG0581@2|Bacteria,4NGU9@976|Bacteroidetes,2G353@200643|Bacteroidia 976|Bacteroidetes P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_657713_2 1168034.FH5T_10225 1.06e-46 158.0 COG0573@1|root,COG0573@2|Bacteria,4NEGX@976|Bacteroidetes,2G32P@200643|Bacteroidia 976|Bacteroidetes P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_526740_1 483215.BACFIN_06959 1.11e-52 177.0 COG2957@1|root,COG2957@2|Bacteria,4NGF8@976|Bacteroidetes,2FMQH@200643|Bacteroidia,4AKP1@815|Bacteroidaceae 976|Bacteroidetes E Psort location Cytoplasmic, score 8.96 aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_362954_1 314285.KT71_12610 7.93e-94 292.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1J9RR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_101720_1 1249627.D779_1675 3.11e-06 47.8 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1WW40@135613|Chromatiales 135613|Chromatiales L TIGRFAM Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_101720_2 1089550.ATTH01000001_gene182 1.3e-41 150.0 COG5621@1|root,COG5621@2|Bacteria,4PAKG@976|Bacteroidetes,1FJV2@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_167300_1 1049564.TevJSym_aa02120 2.11e-15 80.1 2E15V@1|root,32WKS@2|Bacteria,1N30I@1224|Proteobacteria,1SQXV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_134493_2 1123037.AUDE01000010_gene2325 2.14e-64 207.0 COG1741@1|root,COG1741@2|Bacteria,4NGJ5@976|Bacteroidetes,1HYY2@117743|Flavobacteriia 976|Bacteroidetes T Belongs to the pirin family yhhW - - ko:K06911 - - - - ko00000 - - - Pirin k59_983962_1 1537917.JU82_06840 0.0 924.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2YMH2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_919185_1 1026882.MAMP_02816 8.63e-183 525.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,45ZNP@72273|Thiotrichales 72273|Thiotrichales T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_199421_1 331678.Cphamn1_1974 1.14e-20 94.7 COG0472@1|root,COG0472@2|Bacteria,1FETA@1090|Chlorobi 1090|Chlorobi M PFAM glycosyl transferase family 4 - - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_362962_1 1168034.FH5T_21790 9.61e-120 357.0 COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,2FQQ7@200643|Bacteroidia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family pruA - 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh k59_919191_1 439235.Dalk_1134 3.55e-97 296.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,43BQX@68525|delta/epsilon subdivisions,2X71W@28221|Deltaproteobacteria,2MIFV@213118|Desulfobacterales 28221|Deltaproteobacteria P Sodium:sulfate symporter transmembrane region - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_885665_1 1168034.FH5T_10700 9.02e-98 295.0 COG0577@1|root,COG0577@2|Bacteria,4NFUG@976|Bacteroidetes,2FM5B@200643|Bacteroidia 976|Bacteroidetes V Efflux ABC transporter, permease protein macB_3 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_885665_2 1168034.FH5T_10695 3.99e-101 305.0 COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes,2FNZ2@200643|Bacteroidia 976|Bacteroidetes V Efflux ABC transporter, permease protein - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_265109_1 572544.Ilyop_1230 0.0 1155.0 COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,379E9@32066|Fusobacteria 32066|Fusobacteria C belongs to the iron- containing alcohol dehydrogenase family - - 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 - R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 - - - Aldedh,Fe-ADH k59_265109_2 526218.Sterm_0388 1.16e-33 124.0 COG0682@1|root,COG0682@2|Bacteria,37843@32066|Fusobacteria 32066|Fusobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_167937_1 1085623.GNIT_1282 8.27e-20 81.3 2EK1G@1|root,33DRY@2|Bacteria,1NH6C@1224|Proteobacteria,1SGMZ@1236|Gammaproteobacteria,468WX@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3012) - - - - - - - - - - - - DUF3012 k59_167937_2 387631.Asulf_01706 9.61e-43 144.0 COG1814@1|root,arCOG01096@2157|Archaea 2157|Archaea S membrane - - - - - - - - - - - - VIT1 k59_853915_1 1288963.ADIS_3499 5.5e-37 143.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47MTC@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_625017_1 1395571.TMS3_0107950 7.04e-100 298.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_4715 TIM k59_625017_2 292415.Tbd_1135 1.82e-10 61.2 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,1KRIN@119069|Hydrogenophilales 119069|Hydrogenophilales G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_199934_1 1210884.HG799465_gene11989 5.29e-57 189.0 COG0764@1|root,COG0764@2|Bacteria,2IYQE@203682|Planctomycetes 203682|Planctomycetes IQ FabA-like domain - - - - - - - - - - - - FabA,Ketoacyl-synt_C,ketoacyl-synt k59_396321_1 1121396.KB893052_gene3382 7e-51 180.0 COG0457@1|root,COG0457@2|Bacteria,1QSIA@1224|Proteobacteria,42PM6@68525|delta/epsilon subdivisions,2WKPH@28221|Deltaproteobacteria,2MIQQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Tetratricopeptide repeats - - - - - - - - - - - - TPR_16 k59_853917_1 1226322.HMPREF1545_00175 1.4e-11 73.6 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,2N8CV@216572|Oscillospiraceae 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg k59_199936_1 1048983.EL17_07960 6.43e-14 76.6 COG0553@1|root,COG0553@2|Bacteria,4NG6P@976|Bacteroidetes,47U7T@768503|Cytophagia 976|Bacteroidetes L SNF2 family N-terminal domain - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_591942_1 1168034.FH5T_18800 4.61e-146 442.0 28HY3@1|root,2Z83I@2|Bacteria,4NHFN@976|Bacteroidetes,2FX5V@200643|Bacteroidia 976|Bacteroidetes S phosphoenolpyruvate carboxykinase (diphosphate) activity - - - - - - - - - - - - - k59_494555_1 983917.RGE_44760 7.75e-61 196.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,1KKA5@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_494555_2 1173263.Syn7502_01195 8.72e-25 104.0 COG0021@1|root,COG0021@2|Bacteria,1G0GC@1117|Cyanobacteria,1GZ7M@1129|Synechococcus 1117|Cyanobacteria H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_625032_2 1049564.TevJSym_be00100 5.92e-82 249.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1J5QQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_625032_3 765910.MARPU_04710 7.95e-11 62.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_2761_1 396588.Tgr7_3073 1.98e-96 293.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,1WXWQ@135613|Chromatiales 135613|Chromatiales L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_102381_1 983548.Krodi_1443 2.43e-06 55.8 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,1HX4C@117743|Flavobacteriia,37E8W@326319|Dokdonia 976|Bacteroidetes S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_560073_2 7668.SPU_016181-tr 1.03e-05 56.2 KOG1215@1|root,KOG3513@1|root,KOG1215@2759|Eukaryota,KOG3513@2759|Eukaryota,38B6M@33154|Opisthokonta 33154|Opisthokonta T lipoprotein receptor-related protein vldlr - - ko:K20053 - - - - ko00000,ko04131 - - - EGF_CA,FXa_inhibition,Ldl_recept_a,Ldl_recept_b k59_951988_1 387093.SUN_0007 1.46e-108 323.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2YM81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Cysteine desulfurase iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_690461_1 1286171.EAL2_c16820 7.39e-134 389.0 COG1683@1|root,COG1683@2|Bacteria,1UYEA@1239|Firmicutes,24AZT@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF523) - - - - - - - - - - - - DUF523 k59_135129_1 1434929.X946_4987 5.73e-74 230.0 COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VQGX@28216|Betaproteobacteria,1JZP8@119060|Burkholderiaceae 28216|Betaproteobacteria S Pfam Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_135129_2 395493.BegalDRAFT_2999 1.33e-167 481.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,461WQ@72273|Thiotrichales 72273|Thiotrichales E Glutamine synthetase, catalytic domain - - - - - - - - - - - - Gln-synt_C k59_494569_1 439235.Dalk_1499 2.13e-25 110.0 COG0784@1|root,COG3290@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions 1224|Proteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg k59_886114_1 1238182.C882_0659 1.36e-65 224.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,2JR80@204441|Rhodospirillales 204441|Rhodospirillales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_725656_2 927677.ALVU02000001_gene2202 1.05e-64 230.0 COG0438@1|root,COG0438@2|Bacteria,1G9G3@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4 k59_725656_3 796942.HMPREF9623_01255 2.21e-66 214.0 COG1682@1|root,COG1682@2|Bacteria,1TQZF@1239|Firmicutes,248R0@186801|Clostridia 186801|Clostridia GM Transport permease protein - - - ko:K09692 ko02010,map02010 M00251 - - ko00000,ko00001,ko00002,ko02000 3.A.1.104 - - ABC2_membrane k59_725656_4 1121405.dsmv_2646 1.83e-89 288.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,42NNW@68525|delta/epsilon subdivisions,2WMWA@28221|Deltaproteobacteria,2MJQ5@213118|Desulfobacterales 28221|Deltaproteobacteria GM PFAM ABC transporter - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_725656_5 104623.Ser39006_01187 2.28e-63 214.0 COG0110@1|root,COG0110@2|Bacteria,1NBS1@1224|Proteobacteria 1224|Proteobacteria J maltose O-acetyltransferase activity - - - - - - - - - - - - - k59_725656_6 709032.Sulku_2112 9.14e-13 74.3 COG0438@1|root,COG0438@2|Bacteria,1N5HW@1224|Proteobacteria,42PNK@68525|delta/epsilon subdivisions,2YNHS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_856771_1 1049564.TevJSym_as00580 5.65e-23 94.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1J6DD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2863 Cytochrome c553 cc4 - - - - - - - - - - - Cytochrom_C k59_824030_1 1121430.JMLG01000003_gene539 8.04e-41 149.0 COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,26079@186807|Peptococcaceae 186801|Clostridia E TIGRFAM peptidase T-like protein - - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_824030_2 1229487.AMYW01000014_gene2945 1.59e-08 62.0 COG1792@1|root,COG1792@2|Bacteria,4NF14@976|Bacteroidetes,1HWJM@117743|Flavobacteriia,2NSQK@237|Flavobacterium 976|Bacteroidetes M shape-determining protein MreC mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_824030_3 572544.Ilyop_1368 1.4e-32 121.0 COG2834@1|root,COG2834@2|Bacteria,37ASM@32066|Fusobacteria 32066|Fusobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - - k59_954315_5 1283340.Q6WHK7_BPKVM 3.46e-46 152.0 4QAVS@10239|Viruses,4QX2I@35237|dsDNA viruses no RNA stage,4QR41@28883|Caudovirales,4QIEF@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF2829) - - - - - - - - - - - - - k59_954315_7 1121286.AUMT01000010_gene3939 0.000876 47.4 COG1216@1|root,COG1216@2|Bacteria,4NRF1@976|Bacteroidetes,1I2Y2@117743|Flavobacteriia,3ZNYW@59732|Chryseobacterium 976|Bacteroidetes S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_954315_12 665577.JH993790_gene2006 1.28e-109 330.0 COG0451@1|root,COG0451@2|Bacteria,2GJJY@201174|Actinobacteria 201174|Actinobacteria M GDP-mannose 4,6 dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_954315_17 469618.FVAG_00346 4.77e-14 78.6 COG0463@1|root,COG0463@2|Bacteria,37AB4@32066|Fusobacteria 32066|Fusobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_954315_18 941449.dsx2_0370 1.61e-77 244.0 COG0641@1|root,COG0641@2|Bacteria 2|Bacteria C radical SAM - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_954315_20 941449.dsx2_0370 8.92e-73 232.0 COG0641@1|root,COG0641@2|Bacteria 2|Bacteria C radical SAM - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_954315_21 696747.NIES39_A00440 4.89e-16 82.4 COG0457@1|root,COG0457@2|Bacteria,1GGS9@1117|Cyanobacteria 1117|Cyanobacteria S Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21,TPR_11 k59_790917_1 216142.LT40_20610 8.64e-64 219.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_988057_1 387093.SUN_0228 4.47e-99 308.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2YMS1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhF - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_399531_1 1242864.D187_005561 1.1e-10 68.9 COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_138805_1 1408473.JHXO01000004_gene32 1.36e-08 54.3 COG0302@1|root,COG0302@2|Bacteria,4NFC2@976|Bacteroidetes,2FMYB@200643|Bacteroidia 976|Bacteroidetes H GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_138805_2 1033743.CAES01000078_gene3683 2.39e-36 137.0 COG2706@1|root,COG2706@2|Bacteria,1TQ3J@1239|Firmicutes,4HBHB@91061|Bacilli,26SEY@186822|Paenibacillaceae 91061|Bacilli G 3-carboxymuconate cyclase ykgB3 - 3.1.1.31 ko:K07404 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Lactonase k59_367227_1 646529.Desaci_3876 4.82e-22 97.1 COG3972@1|root,COG3972@2|Bacteria,1U80C@1239|Firmicutes,24EBG@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - AAA_19,UvrD_C_2 k59_4741_1 1291050.JAGE01000001_gene2182 7.86e-123 359.0 COG2801@1|root,COG2801@2|Bacteria,1V8EJ@1239|Firmicutes,24MA4@186801|Clostridia 186801|Clostridia L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_29,HTH_8,rve k59_988058_1 911045.PSE_3737 1.37e-29 125.0 COG1289@1|root,COG1289@2|Bacteria 2|Bacteria S transmembrane transporter activity VPA1578 - - - - - - - - - - - FUSC k59_857020_1 435591.BDI_3513 6.15e-112 343.0 COG3316@1|root,COG3316@2|Bacteria,4PKWB@976|Bacteroidetes,2FRWS@200643|Bacteroidia 976|Bacteroidetes L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_399537_1 1265505.ATUG01000001_gene4051 6.57e-44 151.0 COG0745@1|root,COG0745@2|Bacteria,1NRN6@1224|Proteobacteria,42YX2@68525|delta/epsilon subdivisions,2WUBG@28221|Deltaproteobacteria,2MMZJ@213118|Desulfobacterales 28221|Deltaproteobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_628662_1 927658.AJUM01000022_gene1111 2.42e-180 526.0 COG3291@1|root,COG3291@2|Bacteria,4PKMJ@976|Bacteroidetes,2G0FM@200643|Bacteroidia 976|Bacteroidetes G Cellulase N-terminal ig-like domain - GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0033946,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0052736,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CelD_N,Glyco_hydro_9 k59_203507_1 1127673.GLIP_1996 9.98e-111 354.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_758729_1 91464.S7335_3097 2.07e-05 50.8 COG0668@1|root,COG0668@2|Bacteria,1G0ZM@1117|Cyanobacteria,1GZD1@1129|Synechococcus 1117|Cyanobacteria M Conserved TM helix - - - - - - - - - - - - TM_helix k59_758729_2 1121904.ARBP01000003_gene6287 2.2e-92 282.0 COG0668@1|root,COG0668@2|Bacteria,4NF28@976|Bacteroidetes,47P8R@768503|Cytophagia 976|Bacteroidetes M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_758729_3 317025.Tcr_0935 3.96e-80 253.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,460RS@72273|Thiotrichales 72273|Thiotrichales P CorA-like Mg2+ transporter protein - - - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_758729_4 572544.Ilyop_1007 1.53e-143 414.0 COG0530@1|root,COG0530@2|Bacteria,37BU2@32066|Fusobacteria 32066|Fusobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_758729_5 398720.MED217_02590 9.19e-51 164.0 COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,1I2XY@117743|Flavobacteriia,2XK92@283735|Leeuwenhoekiella 976|Bacteroidetes S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_171152_1 768671.ThimaDRAFT_1233 1.74e-50 164.0 2B5BG@1|root,31Y5N@2|Bacteria,1RJ1N@1224|Proteobacteria,1S56J@1236|Gammaproteobacteria,1WYC6@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_171152_2 1286106.MPL1_02493 2.97e-56 187.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,460UR@72273|Thiotrichales 72273|Thiotrichales S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_171152_3 1123372.AUIT01000001_gene816 6.42e-74 241.0 COG2204@1|root,COG2204@2|Bacteria,2GH6P@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_171152_4 1437882.AZRU01000021_gene6206 1.1e-218 627.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1YD2S@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980 ABC_membrane,ABC_tran k59_171152_5 2340.JV46_24910 2.15e-114 336.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1J5ZG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase cysQ GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - iAPECO1_1312.APECO1_2172,iE2348C_1286.E2348C_4545,iEC042_1314.EC042_4695,iEC55989_1330.EC55989_4774,iECABU_c1320.ECABU_c47840,iECIAI1_1343.ECIAI1_4448,iECIAI39_1322.ECIAI39_4686,iECO103_1326.ECO103_5013,iECO111_1330.ECO111_5101,iECO26_1355.ECO26_5384,iECOK1_1307.ECOK1_4735,iECP_1309.ECP_4468,iECSE_1348.ECSE_4520,iECSF_1327.ECSF_4108,iECUMN_1333.ECUMN_4751,iECW_1372.ECW_m4578,iEKO11_1354.EKO11_4094,iEcE24377_1341.EcE24377A_4785,iEcHS_1320.EcHS_A4468,iEcSMS35_1347.EcSMS35_4694,iLF82_1304.LF82_0422,iNRG857_1313.NRG857_21455,iSBO_1134.SBO_4229,iSDY_1059.SDY_4385,iSSON_1240.SSON_4399,iSbBS512_1146.SbBS512_E4758,iUMN146_1321.UM146_21355,iUTI89_1310.UTI89_C4823,iWFL_1372.ECW_m4578,ic_1306.c5313 Inositol_P k59_171152_6 519989.ECTPHS_03979 3.02e-79 241.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1WXW6@135613|Chromatiales 135613|Chromatiales L PFAM NUDIX hydrolase nudE - - ko:K08312 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_171152_7 1049564.TevJSym_ao00540 7.64e-108 316.0 COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1J5ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S hydrolase (HAD superfamily) yrfG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_171152_8 1049564.TevJSym_ao00560 3.04e-68 208.0 COG0727@1|root,COG0727@2|Bacteria,1NXZE@1224|Proteobacteria,1SQVM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_171152_9 1049564.TevJSym_ao00570 5.39e-215 606.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4U6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C,RhlB k59_171152_10 768671.ThimaDRAFT_1374 1.7e-64 197.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1WY87@135613|Chromatiales 135613|Chromatiales O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_171152_11 1049564.TevJSym_ao00590 1.02e-280 769.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1J4QP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_171152_12 521719.ATXQ01000001_gene720 1.14e-26 103.0 COG1077@1|root,COG1077@2|Bacteria 2|Bacteria D Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_171152_13 1049564.TevJSym_ak00150 0.0 998.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_595617_2 1045855.DSC_13520 8.01e-154 450.0 COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,1X3Z6@135614|Xanthomonadales 135614|Xanthomonadales E Splits dipeptides with a prolyl residue in the C- terminal position pepQ - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_595617_3 1234364.AMSF01000075_gene1917 9.01e-05 43.5 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1X701@135614|Xanthomonadales 135614|Xanthomonadales M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_857035_1 870967.VIS19158_17466 1.24e-14 71.2 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1XUSS@135623|Vibrionales 135623|Vibrionales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_857035_2 264732.Moth_1038 4.18e-33 122.0 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,42F7X@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_498131_1 1263831.F543_18610 3.65e-29 115.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1Y6Z7@135625|Pasteurellales 135625|Pasteurellales M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_203509_1 497965.Cyan7822_5116 1.35e-17 87.4 COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1GC1J@1117|Cyanobacteria,3KJVM@43988|Cyanothece 1117|Cyanobacteria QU Polymorphic membrane protein Chlamydia - - - - - - - - - - - - Cadherin k59_726176_1 709032.Sulku_0262 4.99e-22 99.0 COG0464@1|root,COG0464@2|Bacteria,1N4ZI@1224|Proteobacteria,42NGJ@68525|delta/epsilon subdivisions,2YMAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATPase (AAA - - - - - - - - - - - - AAA k59_726176_3 387093.SUN_2238 3.11e-157 471.0 COG1080@1|root,COG1925@1|root,COG1080@2|Bacteria,COG1925@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions 1224|Proteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.1.202,2.7.3.9 ko:K02768,ko:K08483,ko:K11183 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2 k59_726176_4 387093.SUN_2194 2.16e-73 244.0 COG4773@1|root,COG4773@2|Bacteria,1PP2I@1224|Proteobacteria,42WFP@68525|delta/epsilon subdivisions,2YQM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD k59_726176_5 1165841.SULAR_07645 3.37e-17 80.5 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1MY1V@1224|Proteobacteria,42P2P@68525|delta/epsilon subdivisions 1224|Proteobacteria G phosphotransferase system, EIIB nagE GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009401,GO:0009987,GO:0015144,GO:0015764,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0033554,GO:0034219,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0090563,GO:0090586,GO:1901264 2.7.1.193 ko:K02802,ko:K02803,ko:K02804 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 - iECP_1309.ECP_0691 PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_988077_1 864069.MicloDRAFT_00015940 1.6e-14 80.9 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2U3ZY@28211|Alphaproteobacteria,1JZ61@119045|Methylobacteriaceae 28211|Alphaproteobacteria K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_236199_2 1232449.BAHV02000018_gene1587 2.76e-14 72.4 COG3356@1|root,COG3356@2|Bacteria,1VT3S@1239|Firmicutes,24G9C@186801|Clostridia 186801|Clostridia S PFAM Neutral alkaline nonlysosomal ceramidase - - - - - - - - - - - - Ceramidase_alk k59_563475_1 202955.BBND01000005_gene276 9.62e-140 409.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,3NIQX@468|Moraxellaceae 1236|Gammaproteobacteria V HsdM N-terminal domain hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_171157_1 273063.STK_04990 8.11e-24 102.0 COG2048@1|root,arCOG00338@2157|Archaea,2XRI5@28889|Crenarchaeota 28889|Crenarchaeota C Succinate dehydrogenase subunit sdhC - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K00241,ko:K03389 ko00020,ko00190,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00356,M00357,M00374,M00376,M00563,M00567 R02164,R04540,R11928,R11931,R11943,R11944 RC00011,RC00045 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_661694_1 572544.Ilyop_1762 1.99e-26 110.0 COG0760@1|root,COG0760@2|Bacteria,3796T@32066|Fusobacteria 32066|Fusobacteria O peptidylprolyl isomerase - - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_661694_2 1256908.HMPREF0373_01641 1.69e-88 265.0 COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,25VZ2@186806|Eubacteriaceae 186801|Clostridia EH Peptidase C26 trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_661694_3 572544.Ilyop_1763 8.41e-233 652.0 COG2204@1|root,COG2204@2|Bacteria,378JH@32066|Fusobacteria 32066|Fusobacteria T Acetoacetate metabolism regulatory protein atoC - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_661694_4 526218.Sterm_3295 2.13e-17 77.8 2ER6J@1|root,33IS6@2|Bacteria,37B9Q@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_661694_5 1319815.HMPREF0202_01403 1.87e-210 627.0 COG0841@1|root,COG0841@2|Bacteria,378DQ@32066|Fusobacteria 32066|Fusobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_38970_1 944547.ABLL_2827 6.68e-153 447.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,42MI1@68525|delta/epsilon subdivisions,2YMPQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Sulfatase eptA - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_38970_2 572480.Arnit_0607 2.25e-74 225.0 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2YPC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q CoA-binding protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_38970_3 377629.TERTU_1632 4.95e-106 323.0 COG2265@1|root,COG2265@2|Bacteria,1MY45@1224|Proteobacteria,1RN2B@1236|Gammaproteobacteria,2PMWA@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J tRNA (Uracil-5-)-methyltransferase trmA GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.35 ko:K00557 - - - - ko00000,ko01000,ko03016 - - - tRNA_U5-meth_tr k59_465520_1 1168034.FH5T_12025 3.24e-90 273.0 COG2972@1|root,COG2972@2|Bacteria,4NHG3@976|Bacteroidetes,2FUUQ@200643|Bacteroidia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c_5,His_kinase k59_693860_1 471853.Bcav_2952 2.44e-45 164.0 COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria 201174|Actinobacteria C succinate dehydrogenase sdhA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00278 ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00115,M00149,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_923208_1 1313304.CALK_0864 4.23e-24 108.0 COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria 2|Bacteria NT protein-glutamate methylesterase activity cheB - 2.1.1.80,3.1.1.61,3.5.1.44 ko:K03412,ko:K03413,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg k59_790933_1 598659.NAMH_1074 7.92e-105 317.0 COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2YNF4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k59_268132_1 317025.Tcr_1315 8.14e-64 207.0 COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,1RM86@1236|Gammaproteobacteria,45ZTD@72273|Thiotrichales 72273|Thiotrichales M phosphate-selective porin O and P - - - - - - - - - - - - Porin_4 k59_300939_1 269482.Bcep1808_4770 4.33e-05 50.4 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2VN0C@28216|Betaproteobacteria,1JZZE@119060|Burkholderiaceae 28216|Betaproteobacteria D PFAM lipopolysaccharide biosynthesis epsG - 2.7.10.1 ko:K08252,ko:K16692 - - - - ko00000,ko01000,ko01001 - - - AAA_31,CBP_BcsQ,CbiA,GNVR,ParA,Wzz k59_758752_1 767817.Desgi_2713 1.81e-100 306.0 COG0183@1|root,COG0183@2|Bacteria,1UZXX@1239|Firmicutes,249SJ@186801|Clostridia,2610E@186807|Peptococcaceae 186801|Clostridia I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_335000_2 1168034.FH5T_13000 3.31e-41 141.0 COG0664@1|root,COG0664@2|Bacteria,4NKXQ@976|Bacteroidetes 976|Bacteroidetes T cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding k59_431642_1 101510.RHA1_ro02004 2.43e-117 356.0 COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4FURR@85025|Nocardiaceae 201174|Actinobacteria P Arylsulfatase atsB - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - DUF1269,Sulfatase k59_371744_1 1270196.JCKI01000002_gene516 6.43e-59 199.0 COG1397@1|root,COG5113@1|root,COG1397@2|Bacteria,COG3236@2|Bacteria,4NF7H@976|Bacteroidetes,1IP7U@117747|Sphingobacteriia 976|Bacteroidetes O PFAM ADP-ribosylation Crystallin J1 - - - - - - - - - - - - ADP_ribosyl_GH k59_371744_2 1304875.JAFZ01000002_gene288 1.86e-52 184.0 COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,3TCA0@508458|Synergistetes 508458|Synergistetes I Acid phosphatase homologues - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - LssY_C,PAP2,SNARE_assoc k59_143770_1 1168034.FH5T_06720 2.64e-110 338.0 COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,2FMI1@200643|Bacteroidia 976|Bacteroidetes E peptidase S46 dpp7 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009987,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033218,GO:0034641,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_S46 k59_143771_1 439235.Dalk_1934 2.68e-81 253.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2MI0G@213118|Desulfobacterales 28221|Deltaproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_176046_1 675817.VDA_001033 1.19e-114 353.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XTUF@135623|Vibrionales 135623|Vibrionales S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_435982_1 1123392.AQWL01000006_gene636 5.14e-69 229.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfate transporter antisigma-factor antagonist STAS - - - - - - - - - - - - STAS,Sulfate_transp k59_535753_1 913325.N799_08560 1.36e-44 156.0 COG3786@1|root,COG3786@2|Bacteria,1RH22@1224|Proteobacteria,1S2SR@1236|Gammaproteobacteria,1X5KP@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - - - - - - - - - - YkuD k59_469566_1 469617.FUAG_01629 8.93e-50 168.0 COG0451@1|root,COG0451@2|Bacteria,379AQ@32066|Fusobacteria 32066|Fusobacteria M Polysaccharide biosynthesis protein - - 4.2.1.45 ko:K01709 ko00520,map00520 - R02426 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_469566_2 572544.Ilyop_0806 2.64e-68 213.0 COG1208@1|root,COG1208@2|Bacteria,378WP@32066|Fusobacteria 32066|Fusobacteria M Nucleotidyl transferase - - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_7557_1 1168034.FH5T_08360 3.9e-47 159.0 2CC7H@1|root,32RJ0@2|Bacteria,4NIDZ@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_7557_2 1168034.FH5T_08365 7.37e-32 118.0 2BVTQ@1|root,2Z7J9@2|Bacteria,4NGSY@976|Bacteroidetes,2FWJ5@200643|Bacteroidia 976|Bacteroidetes S Protein of unknown function (DUF2797) - - - - - - - - - - - - DUF2797 k59_894402_1 720555.BATR1942_06405 6.28e-93 305.0 COG0236@1|root,COG0451@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0451@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HV19@91061|Bacilli,1ZD1S@1386|Bacillus 91061|Bacilli Q Polyketide synthase of type I - - - ko:K13612,ko:K13613,ko:K13615 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,NAD_binding_4,PP-binding,PS-DH,ketoacyl-synt k59_143786_1 563040.Saut_1808 3.8e-70 214.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2YNW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_77539_1 999541.bgla_2g29730 1.09e-10 68.9 COG0642@1|root,COG2172@1|root,COG2202@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,2VTSU@28216|Betaproteobacteria,1K6T2@119060|Burkholderiaceae 28216|Betaproteobacteria KT Sigma factor PP2C-like phosphatases rsbU - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,HATPase_c_2,PAS_9,SpoIIE,cNMP_binding,dCache_1,dCache_2,sCache_2 k59_861281_1 272568.GDI0543 1.36e-42 155.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2TT73@28211|Alphaproteobacteria,2JPZ4@204441|Rhodospirillales 204441|Rhodospirillales G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_503320_1 945713.IALB_1666 7.71e-40 151.0 COG1290@1|root,COG1290@2|Bacteria 2|Bacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_B_N_2,Cytochrome_B k59_633430_1 1122605.KB893625_gene2191 2.75e-134 390.0 COG4409@1|root,COG4409@2|Bacteria,4NFNK@976|Bacteroidetes,1IRAJ@117747|Sphingobacteriia 976|Bacteroidetes G BNR repeat-like domain - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - BNR_2 k59_861284_1 640081.Dsui_2987 1.55e-06 48.5 2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,2VSTN@28216|Betaproteobacteria,2KWN8@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF1841) - - - - - - - - - - - - DUF1841 k59_861284_2 697282.Mettu_1914 4.08e-102 302.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1XDNH@135618|Methylococcales 135618|Methylococcales L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_272073_1 706587.Desti_0850 1.37e-38 147.0 COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_469579_2 1535422.ND16A_0384 9.31e-55 176.0 COG1495@1|root,COG1495@2|Bacteria,1N2C1@1224|Proteobacteria,1SE4E@1236|Gammaproteobacteria,2Q6U4@267889|Colwelliaceae 1236|Gammaproteobacteria O Disulfide bond formation protein DsbB - - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_110359_1 933262.AXAM01000030_gene799 6.7e-26 107.0 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,42R8E@68525|delta/epsilon subdivisions,2WN6V@28221|Deltaproteobacteria,2MK97@213118|Desulfobacterales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_110359_2 477974.Daud_0126 1.2e-19 86.7 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,260RP@186807|Peptococcaceae 186801|Clostridia F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_927847_1 1123261.AXDW01000007_gene2270 3.85e-99 303.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1X2YI@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_43009_1 944547.ABLL_2638 1.11e-19 87.8 COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,42PDX@68525|delta/epsilon subdivisions,2YR54@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_43009_2 929558.SMGD1_1976 1.46e-31 116.0 COG3216@1|root,COG3216@2|Bacteria,1PSZW@1224|Proteobacteria,42SRF@68525|delta/epsilon subdivisions,2YPQA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_633434_1 1167006.UWK_00110 1.1e-157 453.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2WIXR@28221|Deltaproteobacteria,2MIJ6@213118|Desulfobacterales 28221|Deltaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_633434_2 1167006.UWK_00111 1.44e-17 80.1 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,42PS4@68525|delta/epsilon subdivisions,2WM4V@28221|Deltaproteobacteria,2MJ3B@213118|Desulfobacterales 28221|Deltaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_503328_1 2340.JV46_26220 2.97e-111 333.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1J4U5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN746.PP_0436 S4,tRNA-synt_1b k59_568063_1 443152.MDG893_09681 5.5e-98 314.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,4646K@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_208631_1 1499683.CCFF01000014_gene4005 6.21e-89 266.0 COG1788@1|root,COG1788@2|Bacteria,1V21Q@1239|Firmicutes,25E61@186801|Clostridia,36UK0@31979|Clostridiaceae 186801|Clostridia I TIGRFAM 3-oxoacid CoA-transferase, A subunit - - 2.8.3.8,2.8.3.9 ko:K01034 ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020 - R01179,R01359,R01365,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_208631_2 556263.FSEG_01179 1.54e-11 63.5 COG0183@1|root,COG0183@2|Bacteria,378R0@32066|Fusobacteria 32066|Fusobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_763243_1 326298.Suden_0075 2.8e-118 349.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2YMCM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_7573_1 1227497.C491_14497 0.000623 42.4 COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,23SK1@183963|Halobacteria 183963|Halobacteria C COG0281 Malic enzyme - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_7573_2 340099.Teth39_0462 2.09e-54 183.0 COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,42ETK@68295|Thermoanaerobacterales 186801|Clostridia H Belongs to the acetokinase family buk GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761 2.7.2.7 ko:K00929 ko00650,ko01100,map00650,map01100 - R01688 RC00002,RC00043 ko00000,ko00001,ko01000 - - - Acetate_kinase k59_698273_2 349741.Amuc_1026 4.4e-46 153.0 COG0652@1|root,COG0652@2|Bacteria,46V73@74201|Verrucomicrobia,2IU91@203494|Verrucomicrobiae 203494|Verrucomicrobiae O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_1024768_1 1049564.TevJSym_ap00680 5.23e-109 333.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1024768_2 323261.Noc_2568 1.38e-51 172.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1WXND@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_793778_1 869213.JCM21142_62415 3.77e-94 301.0 COG1629@1|root,COG4771@2|Bacteria,4NF05@976|Bacteroidetes,47K7I@768503|Cytophagia 976|Bacteroidetes P Outer membrane receptor for ferrienterochelin and colicins - - - ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_829026_1 1449126.JQKL01000026_gene2439 7.51e-06 47.4 COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia,268XM@186813|unclassified Clostridiales 186801|Clostridia E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_829026_2 1410653.JHVC01000019_gene2164 2.14e-74 226.0 COG1854@1|root,COG1854@2|Bacteria,1V1CH@1239|Firmicutes,24G3R@186801|Clostridia,36I3G@31979|Clostridiaceae 186801|Clostridia H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) luxS - 4.4.1.21 ko:K07173 ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 M00609 R01291 RC00069,RC01929 ko00000,ko00001,ko00002,ko01000 - - - LuxS k59_829026_3 931276.Cspa_c16090 1.34e-75 235.0 COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,24AE1@186801|Clostridia,36GKK@31979|Clostridiaceae 186801|Clostridia E Vitamin B12 dependent methionine synthase activation metH2 - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Met_synt_B12 k59_829026_4 1487921.DP68_01000 5.4e-33 128.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,36DUH@31979|Clostridiaceae 186801|Clostridia E Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans k59_633447_1 421531.IX38_16260 3.01e-32 129.0 COG1479@1|root,COG1479@2|Bacteria,4PA8Y@976|Bacteroidetes,1IGPA@117743|Flavobacteriia,3ZT0X@59732|Chryseobacterium 976|Bacteroidetes S Protein of unknown function (DUF1524) - - - - - - - - - - - - DUF1524,DUF262 k59_894438_1 998674.ATTE01000001_gene4468 2.72e-26 103.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Phosphoglycolate phosphatase gph GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756 HAD_2 k59_894438_2 1165841.SULAR_02728 2.86e-39 142.0 COG0665@1|root,COG0665@2|Bacteria,1QV9J@1224|Proteobacteria,42PP0@68525|delta/epsilon subdivisions,2YNBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_176102_1 96561.Dole_2197 7.5e-106 314.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2MIBA@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24,SEC-C k59_469594_1 572544.Ilyop_1389 4.13e-54 170.0 COG0211@1|root,COG0211@2|Bacteria,37ACF@32066|Fusobacteria 32066|Fusobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_469594_2 469604.HMPREF0946_01763 1.37e-165 473.0 COG0536@1|root,COG0536@2|Bacteria,3793K@32066|Fusobacteria 32066|Fusobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k59_959549_1 765914.ThisiDRAFT_0718 1.71e-174 511.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_730089_1 1168034.FH5T_03115 9.01e-99 295.0 COG4624@1|root,COG5002@1|root,COG4624@2|Bacteria,COG5002@2|Bacteria,4NFXC@976|Bacteroidetes,2FP4U@200643|Bacteroidia 976|Bacteroidetes C Iron only hydrogenase large subunit, C-terminal domain - - - - - - - - - - - - FeS,Fe_hyd_lg_C,Fer4,Fer4_10 k59_436032_1 1120951.AUBG01000005_gene2099 4.61e-110 328.0 COG0144@1|root,COG0144@2|Bacteria,4NEV7@976|Bacteroidetes,1HXH7@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family rsmB - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N k59_861315_1 591023.AM202_03095 2.85e-103 308.0 2AKRW@1|root,31BIT@2|Bacteria,1RK6Q@1224|Proteobacteria,1S7DH@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_340019_1 870187.Thini_0745 5.91e-27 116.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,462CG@72273|Thiotrichales 72273|Thiotrichales M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM k59_894450_1 765912.Thimo_2434 1.18e-63 211.0 COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2FP@1236|Gammaproteobacteria,1WWXW@135613|Chromatiales 135613|Chromatiales C PFAM 2Fe-2S iron-sulfur cluster binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2 k59_927882_1 1205753.A989_06163 5.17e-35 126.0 COG3157@1|root,COG3157@2|Bacteria,1RBTU@1224|Proteobacteria,1S39K@1236|Gammaproteobacteria,1X83Z@135614|Xanthomonadales 135614|Xanthomonadales S Type VI secretion system effector, Hcp - - - ko:K11903 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 - - - T6SS_HCP k59_894453_1 1123261.AXDW01000007_gene2232 9.11e-129 376.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,1RMRY@1236|Gammaproteobacteria,1X4SK@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_340034_1 177437.HRM2_28110 2.65e-07 51.6 COG2820@1|root,COG2820@2|Bacteria,1QW1B@1224|Proteobacteria,42R3X@68525|delta/epsilon subdivisions,2WP50@28221|Deltaproteobacteria,2MKA8@213118|Desulfobacterales 28221|Deltaproteobacteria F PFAM purine or other phosphorylase family 1 - - - - - - - - - - - - PNP_UDP_1 k59_340034_2 1304275.C41B8_12405 2.86e-20 91.3 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_894464_1 402881.Plav_1997 1.31e-72 229.0 COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria,1JN1M@119043|Rhodobiaceae 28211|Alphaproteobacteria E N-formylglutamate amidohydrolase MA20_06380 - 3.5.1.68 ko:K01458 ko00340,ko00630,map00340,map00630 - R00525 RC00165,RC00323 ko00000,ko00001,ko01000 - - - FGase k59_600816_1 908937.Prede_1999 3.97e-32 130.0 COG2461@1|root,COG2461@2|Bacteria,4NJQA@976|Bacteroidetes 976|Bacteroidetes S Hemerythrin HHE cation binding domain protein - - - ko:K09155 - - - - ko00000 - - - DUF1858,Hemerythrin,PAS_10 k59_894466_1 525898.Sdel_0997 3.55e-31 127.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42WHR@68525|delta/epsilon subdivisions,2YRK3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_793795_1 521719.ATXQ01000006_gene1379 2.26e-47 170.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1YEAX@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_77599_1 373903.Hore_08450 2.43e-07 57.8 COG1033@1|root,COG1033@2|Bacteria,1VSWA@1239|Firmicutes,247R6@186801|Clostridia,3WB6E@53433|Halanaerobiales 186801|Clostridia S hydrophobe amphiphile efflux-3 (HAE3) family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_340036_1 396588.Tgr7_1486 1.8e-21 89.4 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WY2N@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_340036_2 870187.Thini_1269 5.69e-111 330.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,4606V@72273|Thiotrichales 72273|Thiotrichales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_469620_1 1198232.CYCME_0191 8.6e-66 221.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,45ZUX@72273|Thiotrichales 72273|Thiotrichales L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_371827_1 572477.Alvin_2103 2.7e-29 119.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_698319_1 1209989.TepiRe1_1906 1.09e-34 128.0 COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,42J8I@68295|Thermoanaerobacterales 186801|Clostridia M NAD(P)H-binding lspL - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_600822_1 203119.Cthe_0295 5.72e-62 201.0 COG1932@1|root,COG1932@2|Bacteria,1UHH6@1239|Firmicutes,25Q8I@186801|Clostridia,3WI3X@541000|Ruminococcaceae 186801|Clostridia EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine - - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_503381_1 1168034.FH5T_09545 4.95e-71 221.0 COG1475@1|root,COG1475@2|Bacteria,4NFZ9@976|Bacteroidetes,2FP81@200643|Bacteroidia 976|Bacteroidetes K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_503381_2 1168034.FH5T_09550 1.18e-164 463.0 COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,2FMX2@200643|Bacteroidia 976|Bacteroidetes D CobQ CobB MinD ParA nucleotide binding domain soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_208682_1 1121918.ARWE01000001_gene2881 2.32e-87 266.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria 1224|Proteobacteria L IS30 family ISPlu1B - - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_535849_1 1172190.M947_01830 4.09e-111 336.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1R5RS@1224|Proteobacteria,42M3K@68525|delta/epsilon subdivisions,2YN6E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM biotin lipoyl attachment domain-containing protein pycB - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_110853_1 138119.DSY1076 1.14e-71 243.0 COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,261B1@186807|Peptococcaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_110853_2 469618.FVAG_00150 3.79e-66 210.0 COG0745@1|root,COG0745@2|Bacteria,379HE@32066|Fusobacteria 32066|Fusobacteria K Psort location Cytoplasmic, score 9.97 - - - - - - - - - - - - Response_reg,Trans_reg_C k59_730700_2 396588.Tgr7_0609 4.68e-33 122.0 COG5608@1|root,COG5608@2|Bacteria,1N6YX@1224|Proteobacteria,1SE9M@1236|Gammaproteobacteria,1WZ5Z@135613|Chromatiales 135613|Chromatiales S SMART Water Stress and Hypersensitive response domain protein - - - - - - - - - - - - LEA_2 k59_144500_2 360911.EAT1b_2575 3.49e-216 633.0 COG1196@1|root,COG1196@2|Bacteria,1U46F@1239|Firmicutes 1239|Firmicutes D nuclear chromosome segregation - - - - - - - - - - - - - k59_895155_1 519989.ECTPHS_06212 1.39e-59 203.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1WWEX@135613|Chromatiales 135613|Chromatiales S PFAM ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_601488_2 1265505.ATUG01000002_gene1772 6.67e-18 85.5 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42SPK@68525|delta/epsilon subdivisions,2WQUG@28221|Deltaproteobacteria,2MNB7@213118|Desulfobacterales 28221|Deltaproteobacteria T Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_82899_63 1049564.TevJSym_bn00080 2.83e-145 421.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1J5P6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_82899_64 1163617.SCD_n00213 1.76e-62 206.0 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria 28216|Betaproteobacteria M TIGRFAM TonB family protein - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2,TonB_C k59_82899_65 1249627.D779_0655 8.04e-80 242.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales 135613|Chromatiales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_82899_66 1249627.D779_0656 3.26e-49 160.0 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1WYAH@135613|Chromatiales 135613|Chromatiales L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_48560_1 1168034.FH5T_18250 9.14e-150 451.0 COG1629@1|root,COG4771@2|Bacteria,4PN1J@976|Bacteroidetes,2G0P2@200643|Bacteroidia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,OMP_b-brl_3 k59_182204_1 292415.Tbd_1582 3.1e-61 209.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,1KSFY@119069|Hydrogenophilales 119069|Hydrogenophilales V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_900248_1 164328.Phyra85044 5.24e-60 206.0 COG0043@1|root,2QR5I@2759|Eukaryota,3QHUS@4776|Peronosporales 4776|Peronosporales H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - 4.1.1.102 ko:K20039 ko00940,map00940 - R02952,R03367 RC00814 ko00000,ko00001,ko01000 - - - UbiD k59_998900_1 1049564.TevJSym_bi00190 3.58e-67 220.0 COG1509@1|root,COG1509@2|Bacteria,1NG2M@1224|Proteobacteria,1SR2C@1236|Gammaproteobacteria 1236|Gammaproteobacteria E lysine 2,3-aminomutase activity - - - - - - - - - - - - - k59_409722_1 1165841.SULAR_03163 4.61e-154 444.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2YM9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_116009_1 590998.Celf_2360 3.29e-33 123.0 COG1305@1|root,COG1305@2|Bacteria,2GN5D@201174|Actinobacteria 201174|Actinobacteria E PFAM transglutaminase domain protein - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_116009_2 312284.A20C1_10600 1.28e-19 87.8 COG2307@1|root,COG2307@2|Bacteria,2GN0T@201174|Actinobacteria 201174|Actinobacteria S protein conserved in bacteria - - - - - - - - - - - - Alpha-E k59_246395_1 488538.SAR116_0293 1.96e-75 233.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,2U3UR@28211|Alphaproteobacteria,4BR6M@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_606838_1 1537917.JU82_09765 1.13e-220 613.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2YMEQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G fructose-bisphosphate aldolase fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_606838_2 1537917.JU82_09755 2.81e-98 306.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42P4R@68525|delta/epsilon subdivisions,2YM92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - DUF3365,MCPsignal k59_441837_1 396588.Tgr7_2800 9.49e-61 203.0 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria,1X2PU@135613|Chromatiales 135613|Chromatiales EGP Drug resistance transporter Bcr CflA subfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_965623_1 5270.UM01028P0 8.05e-15 78.2 COG0432@1|root,KOG4269@1|root,KOG3267@2759|Eukaryota,KOG4269@2759|Eukaryota,38FSR@33154|Opisthokonta,3NVRI@4751|Fungi,3UXTA@5204|Basidiomycota,3N1TW@452284|Ustilaginomycotina 4751|Fungi T GTPase-activator protein for Rho-like GTPases BEM3 GO:0000131,GO:0003674,GO:0005096,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005826,GO:0005856,GO:0005933,GO:0005934,GO:0005937,GO:0005938,GO:0006996,GO:0007010,GO:0007163,GO:0008047,GO:0008150,GO:0008289,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0015629,GO:0016043,GO:0023051,GO:0023057,GO:0030010,GO:0030234,GO:0030427,GO:0030695,GO:0030863,GO:0030864,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032266,GO:0035023,GO:0035024,GO:0035091,GO:0035838,GO:0042995,GO:0043085,GO:0043087,GO:0043167,GO:0043168,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043332,GO:0043547,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044463,GO:0044464,GO:0046578,GO:0046580,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0051056,GO:0051058,GO:0051286,GO:0051336,GO:0051345,GO:0060589,GO:0065007,GO:0065009,GO:0070938,GO:0071840,GO:0071944,GO:0098772,GO:0099568,GO:0120025,GO:0120038,GO:0120105,GO:1901981,GO:1902531,GO:1902532 - ko:K08773,ko:K19840 ko04011,ko04014,ko05200,ko05212,map04011,map04014,map05200,map05212 - - - ko00000,ko00001,ko04131 - - - PH,PX,RhoGAP k59_214770_1 1121405.dsmv_1755 1.8e-70 231.0 COG1085@1|root,COG1085@2|Bacteria,1R6SM@1224|Proteobacteria,42QFF@68525|delta/epsilon subdivisions,2WKFN@28221|Deltaproteobacteria,2MIE7@213118|Desulfobacterales 28221|Deltaproteobacteria C galactose-1-phosphate uridylyltransferase - - - - - - - - - - - - - k59_246398_1 870187.Thini_0748 2.64e-107 340.0 COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,1T41W@1236|Gammaproteobacteria 1236|Gammaproteobacteria C catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second - - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_704245_1 929558.SMGD1_1281 6.89e-63 209.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2YMJR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaGprimase_HBD,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_377388_2 1125699.HMPREF9194_00577 8.24e-30 119.0 COG2861@1|root,COG2861@2|Bacteria,2J75Z@203691|Spirochaetes 203691|Spirochaetes S Divergent polysaccharide deacetylase - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_474965_1 1049564.TevJSym_ad01120 0.0 1171.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1J5AR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_474965_2 1049564.TevJSym_bh00320 2.4e-159 454.0 COG0583@1|root,COG0583@2|Bacteria,1MUWX@1224|Proteobacteria,1RYWC@1236|Gammaproteobacteria,1JB8E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_474965_3 1415778.JQMM01000001_gene365 3.88e-158 463.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,1S01Y@1236|Gammaproteobacteria,1J5XZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_474965_5 640081.Dsui_3327 1.42e-53 180.0 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2VQQ0@28216|Betaproteobacteria,2KW85@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome - - - - - - - - - - - - Ni_hydr_CYTB k59_474965_6 935565.JAEM01000004_gene3036 3.39e-15 75.5 COG3909@1|root,COG3909@2|Bacteria,1N1E5@1224|Proteobacteria,2U9A1@28211|Alphaproteobacteria,2PW1F@265|Paracoccus 28211|Alphaproteobacteria C Cytochrome C' - - - - - - - - - - - - Cytochrom_C_2 k59_474965_7 574966.KB898646_gene2782 1.09e-65 224.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,1XKB2@135619|Oceanospirillales 135619|Oceanospirillales M HlyD membrane-fusion protein of T1SS - - - ko:K12537,ko:K16300 - M00328,M00571 - - ko00000,ko00002,ko02000,ko02044 8.A.1,8.A.1.3.3 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_474965_8 1357272.AVEO02000190_gene4332 7.27e-74 241.0 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,1T1HR@1236|Gammaproteobacteria,1Z8EX@136849|Pseudomonas syringae group 1236|Gammaproteobacteria V ABC transporter transmembrane region - - - ko:K06148,ko:K12536 ko02010,map02010 M00328 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1,3.A.1.110 - - ABC_membrane,ABC_tran k59_277572_1 401053.AciPR4_2236 2.91e-44 163.0 COG3250@1|root,COG3250@2|Bacteria,3Y6RC@57723|Acidobacteria,2JKAB@204432|Acidobacteriia 204432|Acidobacteriia G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_12508_1 765913.ThidrDRAFT_0365 1.57e-102 311.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1WW9T@135613|Chromatiales 135613|Chromatiales P PFAM Citrate transporter - - - - - - - - - - - - CitMHS k59_998926_2 1249997.JHZW01000002_gene789 5.81e-14 73.9 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,4NHCZ@976|Bacteroidetes,1HXNK@117743|Flavobacteriia,2PHZF@252356|Maribacter 976|Bacteroidetes S CHAT domain - - - - - - - - - - - - CHAT,TPR_10,TPR_12,TPR_7,TPR_8 k59_441860_1 1168034.FH5T_14185 7.35e-100 299.0 COG0860@1|root,COG0860@2|Bacteria,4NHZA@976|Bacteroidetes,2FP3Y@200643|Bacteroidia 976|Bacteroidetes M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_311142_1 1408473.JHXO01000012_gene459 2.57e-131 402.0 COG0587@1|root,COG0587@2|Bacteria,4NFA0@976|Bacteroidetes,2FNND@200643|Bacteroidia 976|Bacteroidetes L DNA polymerase - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_1030308_1 1120953.AUBH01000001_gene659 2.79e-58 196.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,46411@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_1030308_2 61273.S3CW09 6.7e-40 142.0 COG2110@1|root,KOG2633@2759|Eukaryota,38JYP@33154|Opisthokonta,3NY56@4751|Fungi,3QP9U@4890|Ascomycota,2117J@147550|Sordariomycetes,3UTP1@5151|Ophiostomatales 4751|Fungi BK Appr-1'-p processing enzyme - - - - - - - - - - - - Macro k59_509557_1 159087.Daro_0979 5.38e-109 333.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VHW2@28216|Betaproteobacteria,2KUYG@206389|Rhodocyclales 206389|Rhodocyclales C Respiratory-chain NADH dehydrogenase hoxF - 1.12.1.2 ko:K18005 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_509557_2 1244869.H261_09864 1.67e-25 100.0 COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria 1224|Proteobacteria C NADH ubiquinone oxidoreductase hoxU - 1.12.1.2 ko:K18006 - - - - ko00000,ko01000 - - - Fer2_4,Fer4_15,NADH-G_4Fe-4S_3 k59_1031131_3 1168034.FH5T_08165 1.87e-136 393.0 COG0667@1|root,COG0667@2|Bacteria,4NFCN@976|Bacteroidetes,2FMAG@200643|Bacteroidia 976|Bacteroidetes C aldo keto reductase family gpr - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red k59_150436_1 1463895.JODA01000002_gene1154 0.000134 50.4 COG4908@1|root,COG4908@2|Bacteria,2I35G@201174|Actinobacteria 201174|Actinobacteria S Belongs to the long-chain O-acyltransferase family - - - - - - - - - - - - DUF1298,WES_acyltransf k59_835638_1 477184.KYC_14907 2.1e-24 105.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VII1@28216|Betaproteobacteria 28216|Betaproteobacteria L similarity to GP 17427840 - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve_3 k59_49320_2 1123519.PSJM300_13315 7.46e-50 175.0 COG0028@1|root,COG0028@2|Bacteria,1P76A@1224|Proteobacteria,1RP3S@1236|Gammaproteobacteria,1Z0H2@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria EH COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_116771_2 694427.Palpr_0863 1.59e-15 77.8 COG0823@1|root,COG0823@2|Bacteria,4NGH4@976|Bacteroidetes,2FN8G@200643|Bacteroidia,22Z6E@171551|Porphyromonadaceae 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_542270_1 272134.KB731324_gene6644 3.17e-19 81.6 COG3677@1|root,COG3677@2|Bacteria,1GEJ0@1117|Cyanobacteria,1HFYP@1150|Oscillatoriales 1117|Cyanobacteria L InsA C-terminal domain - - - - - - - - - - - - HTH_Tnp_IS1,Zn_Tnp_IS1 k59_542270_2 1499967.BAYZ01000134_gene17 6.91e-24 94.4 COG1662@1|root,COG1662@2|Bacteria 2|Bacteria L PFAM IS1 transposase insB GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K07480 - - - - ko00000 - - - DDE_Tnp_IS1,HTH_Tnp_IS1,Zn_Tnp_IS1 k59_966496_1 1211813.CAPH01000003_gene1380 1.46e-109 331.0 COG0508@1|root,COG0508@2|Bacteria,4NFB9@976|Bacteroidetes,2G2WC@200643|Bacteroidia 976|Bacteroidetes C Psort location Cytoplasmic, score pdhC - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_966496_2 1237149.C900_05698 6.09e-34 120.0 COG0399@1|root,COG0399@2|Bacteria,4NVFZ@976|Bacteroidetes,47S2S@768503|Cytophagia 976|Bacteroidetes J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_510356_2 118168.MC7420_3443 6.01e-37 133.0 COG0778@1|root,COG0778@2|Bacteria,1G5XK@1117|Cyanobacteria,1HFCI@1150|Oscillatoriales 1117|Cyanobacteria C Nitroreductase - - - - - - - - - - - - Nitroreductase k59_13328_1 1168034.FH5T_17660 1.77e-118 372.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,4NHCZ@976|Bacteroidetes,2G2X1@200643|Bacteroidia 976|Bacteroidetes S CHAT domain - - - - - - - - - - - - CHAT,TPR_12,TPR_7,TPR_8 k59_999719_1 765913.ThidrDRAFT_3371 1.45e-26 105.0 COG0561@1|root,COG0561@2|Bacteria,1QDJR@1224|Proteobacteria,1RSEI@1236|Gammaproteobacteria,1WX4S@135613|Chromatiales 135613|Chromatiales S HAD-superfamily hydrolase, subfamily IIB - - - - - - - - - - - - S6PP,YcgL k59_999719_2 572477.Alvin_0252 1.91e-30 120.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales 135613|Chromatiales M HAD-superfamily hydrolase, subfamily IIB - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_510366_1 754477.Q7C_2507 1.88e-61 212.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,45ZMV@72273|Thiotrichales 72273|Thiotrichales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_2,OstA_C k59_116788_1 1168034.FH5T_17230 3.13e-36 135.0 COG0129@1|root,COG0129@2|Bacteria,4NFHP@976|Bacteroidetes,2FMCC@200643|Bacteroidia 976|Bacteroidetes EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_736521_1 85643.Tmz1t_2823 5.23e-233 668.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,2KVNP@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_966513_1 1168034.FH5T_11505 4.68e-53 172.0 COG0494@1|root,COG0494@2|Bacteria,4NM6C@976|Bacteroidetes,2FU3S@200643|Bacteroidia 976|Bacteroidetes L NUDIX domain - - - - - - - - - - - - NUDIX k59_966513_2 1168034.FH5T_11500 9.84e-48 167.0 COG4206@1|root,COG4206@2|Bacteria,4NI2R@976|Bacteroidetes,2FNYT@200643|Bacteroidia 976|Bacteroidetes H Psort location OuterMembrane, score - - - - - - - - - - - - Porin_10 k59_1031170_1 1453496.AT03_04800 2e-60 208.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935 MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1031170_2 1123355.JHYO01000004_gene2554 6.37e-11 59.3 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,36YC9@31993|Methylocystaceae 28211|Alphaproteobacteria C Domain of unknown function (DUF3470) - - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4,Fer4_4 k59_901114_1 1168034.FH5T_09290 5.92e-69 213.0 COG3637@1|root,COG3637@2|Bacteria,4NYY3@976|Bacteroidetes 976|Bacteroidetes M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl,OMP_b-brl_2 k59_901114_2 1168034.FH5T_09295 7.45e-21 88.2 COG0846@1|root,COG0846@2|Bacteria,4NE9Q@976|Bacteroidetes,2FNXN@200643|Bacteroidia 976|Bacteroidetes K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_378145_1 1227487.C474_06877 2.48e-18 79.3 arCOG11411@1|root,arCOG11411@2157|Archaea,2XZE4@28890|Euryarchaeota,23WZ5@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - k59_966525_2 765913.ThidrDRAFT_0016 3.8e-47 160.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1WWHZ@135613|Chromatiales 135613|Chromatiales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_410558_1 1168289.AJKI01000001_gene3631 1.94e-153 442.0 COG0189@1|root,COG4067@1|root,COG0189@2|Bacteria,COG4067@2|Bacteria,4NED4@976|Bacteroidetes,2FWBV@200643|Bacteroidia 976|Bacteroidetes HJO Putative ATP-dependant zinc protease rimK - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK,Zn_protease k59_966533_1 335543.Sfum_0379 2.4e-125 369.0 COG1541@1|root,COG1541@2|Bacteria,1MXF5@1224|Proteobacteria,42MZA@68525|delta/epsilon subdivisions,2WIUC@28221|Deltaproteobacteria,2MRDJ@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_705107_1 1095769.CAHF01000011_gene2676 1.03e-139 420.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,472NE@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aconitase C-terminal domain acnD - 4.2.1.117,4.2.1.3 ko:K01681,ko:K20455 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900,R11263 RC00497,RC00498,RC00618,RC01152 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_410562_1 631362.Thi970DRAFT_02476 3.25e-164 471.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_150482_2 323261.Noc_3068 5.51e-41 150.0 COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales 135613|Chromatiales M sucrose synthase - - 2.4.1.13 ko:K00695 ko00500,ko01100,map00500,map01100 - R00806 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000,ko01003 - GT4 - Glycos_transf_1,Sucrose_synth k59_1031192_1 360104.CCC13826_1233 2.4e-51 166.0 COG3829@1|root,COG3829@2|Bacteria,1NG3B@1224|Proteobacteria,43AE4@68525|delta/epsilon subdivisions,2YT0Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT PAS sensor protein - - - - - - - - - - - - PAS,PAS_3 k59_49361_1 717774.Marme_2392 4.14e-124 368.0 COG1119@1|root,COG1119@2|Bacteria,1MVVM@1224|Proteobacteria,1RMXK@1236|Gammaproteobacteria,1XH3Q@135619|Oceanospirillales 135619|Oceanospirillales P ATPases associated with a variety of cellular activities - - - ko:K05776 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 - - - ABC_tran k59_116818_1 1168034.FH5T_10935 4.4e-81 247.0 COG0074@1|root,COG0074@2|Bacteria,4NE6B@976|Bacteroidetes,2FM2M@200643|Bacteroidia 976|Bacteroidetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA,Succ_CoA_lig k59_116818_2 1107311.Q767_05875 1.42e-19 87.0 COG1327@1|root,COG1327@2|Bacteria,4NHXI@976|Bacteroidetes,1HYJ8@117743|Flavobacteriia,2NUTK@237|Flavobacterium 976|Bacteroidetes K Restriction endonuclease - - - - - - - - - - - - ATP-cone,Mrr_cat k59_799677_1 1537917.JU82_10390 5.05e-116 337.0 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,42Z77@68525|delta/epsilon subdivisions,2YRAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_247223_1 857087.Metme_3442 1.12e-69 238.0 COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,1RPQ2@1236|Gammaproteobacteria,1XDMI@135618|Methylococcales 135618|Methylococcales S Type VI secretion protein IcmF C-terminal - - - ko:K11891 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - IcmF-related,IcmF_C,ImcF-related_N k59_215614_1 1207063.P24_16892 1.87e-18 91.7 COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2U26R@28211|Alphaproteobacteria,2JPQ3@204441|Rhodospirillales 204441|Rhodospirillales M AsmA family - - - ko:K07289,ko:K07290 - - - - ko00000 9.B.121 - - AsmA,AsmA_2 k59_83771_1 1049564.TevJSym_bf00220 4.07e-58 192.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1J707@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Metal dependent phosphohydrolases with conserved 'HD' motif. dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_410570_2 861452.HMPREF9093_00195 4.99e-37 133.0 28Q2Y@1|root,2ZCKR@2|Bacteria,37A0D@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_709512_1 1249480.B649_01805 1.89e-82 258.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2YN9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_709512_2 1172190.M947_03745 1.03e-83 271.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2YMAH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the ClpA ClpB family clpB - - ko:K03694,ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_382522_1 1168034.FH5T_05020 1.97e-31 127.0 COG1520@1|root,COG1520@2|Bacteria,4NHQ3@976|Bacteroidetes,2FQ6V@200643|Bacteroidia 976|Bacteroidetes S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - DUF3352 k59_382524_1 1168034.FH5T_20290 1.7e-12 69.7 COG1418@1|root,COG1418@2|Bacteria,4NE3V@976|Bacteroidetes,2FKZ6@200643|Bacteroidia 976|Bacteroidetes D Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_382524_2 1168034.FH5T_20295 3.38e-10 57.0 2EQ1I@1|root,33HMZ@2|Bacteria 2|Bacteria D Cell division protein ZapA - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_88467_1 1537917.JU82_04645 2.29e-72 230.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2YMA9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_88467_2 709032.Sulku_0758 9.68e-61 195.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2YMRV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_938612_1 96561.Dole_0030 2.96e-35 137.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4585@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4585@2|Bacteria,1RGKE@1224|Proteobacteria,43DX3@68525|delta/epsilon subdivisions,2X71G@28221|Deltaproteobacteria,2MIM1@213118|Desulfobacterales 28221|Deltaproteobacteria KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA_3,Pkinase,STAS k59_1035291_1 572544.Ilyop_1552 5.09e-71 225.0 COG0132@1|root,COG1435@1|root,COG0132@2|Bacteria,COG1435@2|Bacteria,378FT@32066|Fusobacteria 32066|Fusobacteria F thymidine kinase tdk - 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK k59_840115_1 1500890.JQNL01000001_gene244 6.77e-53 184.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1X9B3@135614|Xanthomonadales 135614|Xanthomonadales IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_53726_1 1537917.JU82_11270 1.51e-56 181.0 COG0235@1|root,COG0235@2|Bacteria,1N84G@1224|Proteobacteria,42RVW@68525|delta/epsilon subdivisions,2YP4S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II k59_53726_2 1172190.M947_09600 2.69e-34 125.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2YMRK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_480164_1 1165841.SULAR_08527 2.46e-17 79.0 COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,42VE6@68525|delta/epsilon subdivisions 1224|Proteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - - k59_383466_1 469617.FUAG_00534 1.62e-13 68.9 COG1482@1|root,COG1482@2|Bacteria,378PU@32066|Fusobacteria 32066|Fusobacteria G mannose-6-phosphate isomerase manA - 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 - - - PMI_typeI k59_383466_2 572544.Ilyop_0477 3.01e-29 108.0 COG2190@1|root,COG2190@2|Bacteria,37A1G@32066|Fusobacteria 32066|Fusobacteria G PTS system crr - - ko:K02777 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1 - - PTS_EIIA_1 k59_579620_1 1172190.M947_11010 2.96e-65 212.0 COG0475@1|root,COG0475@2|Bacteria,1N2RV@1224|Proteobacteria,43B2N@68525|delta/epsilon subdivisions,2YT5E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_54553_1 1168034.FH5T_15125 1.63e-82 261.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,4NEKW@976|Bacteroidetes,2FM5V@200643|Bacteroidia 976|Bacteroidetes M Transglycosylase SLT domain mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_383470_1 1121405.dsmv_3317 4.28e-39 149.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales 28221|Deltaproteobacteria KT Sigma-54 interaction domain - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_613124_1 1123253.AUBD01000001_gene1780 9.22e-107 327.0 COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,1RMAI@1236|Gammaproteobacteria,1X5D5@135614|Xanthomonadales 135614|Xanthomonadales H AbgT putative transporter family - - - - - - - - - - - - ABG_transport k59_645639_1 1095747.HMPREF1049_1089 1.86e-11 63.9 COG1206@1|root,COG1206@2|Bacteria,378A1@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_645639_2 572544.Ilyop_0527 5.24e-64 203.0 COG4974@1|root,COG4974@2|Bacteria,378JM@32066|Fusobacteria 32066|Fusobacteria L Belongs to the 'phage' integrase family xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_220756_1 572544.Ilyop_0221 1.81e-104 315.0 COG1055@1|root,COG1055@2|Bacteria,378C3@32066|Fusobacteria 32066|Fusobacteria P Arsenical pump membrane protein - - - - - - - - - - - - CitMHS k59_220756_2 572544.Ilyop_0220 5.34e-79 246.0 COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria,379JW@32066|Fusobacteria 32066|Fusobacteria GT Psort location Cytoplasmic, score 8.96 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - CBS,PTS_EIIA_2 k59_971858_1 1232410.KI421424_gene1701 2.67e-19 86.7 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria,43SC2@69541|Desulfuromonadales 28221|Deltaproteobacteria O PFAM magnesium chelatase ChlI subunit comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_547573_1 1172190.M947_06775 2.99e-160 461.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2YMQM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_89362_1 543913.D521_0711 2.09e-88 281.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2VJ5N@28216|Betaproteobacteria 28216|Betaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_939394_1 1485544.JQKP01000002_gene1357 3.79e-16 79.7 COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,2WGMC@28216|Betaproteobacteria,44V6B@713636|Nitrosomonadales 28216|Betaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1036290_1 713586.KB900536_gene2239 8.72e-112 328.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1WX13@135613|Chromatiales 135613|Chromatiales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_613141_1 387093.SUN_0169 5.44e-87 274.0 COG2956@1|root,COG2956@2|Bacteria,1PDTB@1224|Proteobacteria,42PNY@68525|delta/epsilon subdivisions,2YN3M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the low molecular weight phosphotyrosine protein phosphatase family ciaB - - - - - - - - - - - - k59_317091_1 96561.Dole_2220 1.96e-87 267.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2MI9R@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_480924_1 748727.CLJU_c28410 3.43e-16 84.0 COG0210@1|root,COG0210@2|Bacteria,1V0R3@1239|Firmicutes,24820@186801|Clostridia,36JW7@31979|Clostridiaceae 186801|Clostridia L DNA helicase - - - - - - - - - - - - - k59_840911_1 1168034.FH5T_05480 1.47e-38 138.0 COG1453@1|root,COG1453@2|Bacteria,4NGCW@976|Bacteroidetes,2FPG8@200643|Bacteroidia 976|Bacteroidetes S Tat pathway signal sequence domain protein - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 k59_678829_1 1123401.JHYQ01000038_gene1595 6.75e-36 134.0 2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_678829_2 713587.THITH_11945 2.09e-13 68.6 28IET@1|root,2Z8GT@2|Bacteria,1R4FQ@1224|Proteobacteria,1RS8I@1236|Gammaproteobacteria,1WWZ9@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_613159_1 314278.NB231_06950 5.72e-40 149.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales 135613|Chromatiales EH Anthranilate synthase component I - - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_579687_1 1121430.JMLG01000026_gene24 6.08e-15 78.6 COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,25C3N@186801|Clostridia,260TU@186807|Peptococcaceae 186801|Clostridia D Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_906491_1 469618.FVAG_02124 1.71e-22 95.1 COG2148@1|root,COG2148@2|Bacteria,378EQ@32066|Fusobacteria 32066|Fusobacteria M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Bac_transf k59_906491_2 572544.Ilyop_0803 1.01e-177 508.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups wcaI - - ko:K03208 - - - - ko00000 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1 k59_906491_3 1385511.N783_13525 3.36e-27 107.0 COG1089@1|root,COG1089@2|Bacteria 2|Bacteria M GDP-mannose 4,6-dehydratase activity gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_645676_1 1137799.GZ78_24260 2.87e-78 251.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1XH8T@135619|Oceanospirillales 135619|Oceanospirillales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_579690_1 1049564.TevJSym_be00350 7.4e-75 229.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1J59F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_54602_1 768671.ThimaDRAFT_2025 3.04e-59 190.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1WWRR@135613|Chromatiales 135613|Chromatiales S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_515986_1 243159.AFE_2905 2.62e-147 427.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,2NCE4@225057|Acidithiobacillales 225057|Acidithiobacillales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_547615_1 1168034.FH5T_08835 1.08e-92 276.0 COG0767@1|root,COG0767@2|Bacteria,4NEZ8@976|Bacteroidetes,2FNVR@200643|Bacteroidia 976|Bacteroidetes Q Psort location CytoplasmicMembrane, score 10.00 mlaE - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_547615_2 1168034.FH5T_08840 2.57e-119 351.0 COG0836@1|root,COG0836@2|Bacteria,4NE1Y@976|Bacteroidetes,2FNHF@200643|Bacteroidia 976|Bacteroidetes M Mannose-1-phosphate guanylyltransferase manC - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_804946_1 1168034.FH5T_05155 4.44e-83 258.0 COG3474@1|root,COG3474@2|Bacteria,4PKQA@976|Bacteroidetes 976|Bacteroidetes C Quinol cytochrome c oxidoreductase - - - - - - - - - - - - Cytochrom_C,Cytochrom_CIII,Cytochrome_C7 k59_352074_1 1168034.FH5T_16980 1.9e-24 98.2 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding Z012_05310 - - ko:K01420,ko:K10914,ko:K21556,ko:K21562 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_613170_1 1232437.KL662020_gene705 2.54e-87 271.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_317118_1 1122613.ATUP01000001_gene2020 2.16e-53 181.0 COG0627@1|root,COG0627@2|Bacteria,1QIRQ@1224|Proteobacteria,2TUU5@28211|Alphaproteobacteria,43Z22@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Putative esterase - - - - - - - - - - - - Esterase k59_840926_1 1229172.JQFA01000002_gene4350 6.05e-39 143.0 COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1H7A5@1150|Oscillatoriales 1117|Cyanobacteria C NAD NADP transhydrogenase alpha subunit pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_840926_2 1049564.TevJSym_az00150 1.85e-14 72.8 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1J4QW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_54611_2 414684.RC1_3456 3.02e-45 155.0 COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2TQQD@28211|Alphaproteobacteria,2JQ7P@204441|Rhodospirillales 204441|Rhodospirillales P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_579707_1 1128912.GMES_0442 4.7e-34 132.0 COG3385@1|root,COG3385@2|Bacteria,1R55Y@1224|Proteobacteria,1RRSD@1236|Gammaproteobacteria,466PM@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_741747_1 717772.THIAE_08425 3.32e-24 108.0 COG1597@1|root,COG1808@1|root,COG1597@2|Bacteria,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,1RRTC@1236|Gammaproteobacteria,460C0@72273|Thiotrichales 72273|Thiotrichales I Domain of unknown function (DUF389) - - - - - - - - - - - - DUF389 k59_415661_1 1001585.MDS_1585 5.14e-21 95.1 COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,1RPB9@1236|Gammaproteobacteria,1YHC9@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_89416_1 1415779.JOMH01000001_gene3136 8.72e-52 180.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1X9CV@135614|Xanthomonadales 135614|Xanthomonadales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - SBP_bac_5 k59_18842_1 1249480.B649_01625 5.05e-66 223.0 COG2203@1|root,COG2206@1|root,COG3829@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3829@2|Bacteria,1RAQS@1224|Proteobacteria,42QQI@68525|delta/epsilon subdivisions 1224|Proteobacteria T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - CBS,GAF,GAF_2,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9,Response_reg,sCache_2 k59_122338_1 768671.ThimaDRAFT_0777 2.27e-106 322.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales 135613|Chromatiales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_547630_1 218491.ECA2897 1.77e-44 145.0 2EC1F@1|root,3360K@2|Bacteria,1MZIJ@1224|Proteobacteria,1SE4G@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3892) - - - - - - - - - - - - DUF3892 k59_547630_2 865938.Weevi_1960 1.5e-92 276.0 COG1961@1|root,COG1961@2|Bacteria,4NJM8@976|Bacteroidetes,1I0IY@117743|Flavobacteriia 976|Bacteroidetes L Resolvase, N terminal domain - - - - - - - - - - - - HTH_7,Resolvase k59_220801_1 500635.MITSMUL_04133 3.86e-67 219.0 COG1228@1|root,COG1228@2|Bacteria,1UI33@1239|Firmicutes,4H3DF@909932|Negativicutes 909932|Negativicutes E Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation iadA - - - - - - - - - - - Amidohydro_1 k59_741759_1 1267005.KB911255_gene2974 7.89e-52 172.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,3N66R@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_613187_1 1191523.MROS_1011 7.37e-46 163.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_873195_2 1122134.KB893650_gene646 8.88e-13 72.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RRKU@1236|Gammaproteobacteria,1XR0K@135619|Oceanospirillales 135619|Oceanospirillales O Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_939468_1 1027292.HMPREF9372_2168 6.8e-12 66.2 COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,4HBAH@91061|Bacilli,26D34@186818|Planococcaceae 91061|Bacilli P COG1840 ABC-type Fe3 transport system, periplasmic component - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_448196_1 1122603.ATVI01000005_gene3480 2.07e-05 52.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales 1236|Gammaproteobacteria T Tetratricopeptide repeat - - - - - - - - - - - - Guanylate_cyc,TPR_19,TPR_2,TPR_8 k59_383583_1 709032.Sulku_1250 6.78e-23 89.4 COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,42V0C@68525|delta/epsilon subdivisions,2YQBD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Redox-active disulfide protein - - - - - - - - - - - - Thioredoxin_3 k59_383583_2 709032.Sulku_0120 5.49e-71 228.0 COG0715@1|root,COG0715@2|Bacteria,1NV0U@1224|Proteobacteria,42SS6@68525|delta/epsilon subdivisions,2YPMU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - - k59_906525_2 768671.ThimaDRAFT_1994 5.36e-21 92.8 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_728279_3 330214.NIDE0595 2.31e-34 142.0 COG0322@1|root,COG0322@2|Bacteria,3J0F1@40117|Nitrospirae 40117|Nitrospirae L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_302996_1 469616.FMAG_00875 8.64e-45 157.0 COG1044@1|root,COG1044@2|Bacteria,378VP@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_108410_2 762903.Pedsa_0462 8.68e-20 91.7 COG1520@1|root,COG3866@1|root,COG1520@2|Bacteria,COG3866@2|Bacteria,4NG8Z@976|Bacteroidetes,1IWEK@117747|Sphingobacteriia 976|Bacteroidetes G Pectate lyase - - - - - - - - - - - - - k59_664191_1 1535287.JP74_09550 1.91e-18 93.6 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria,3N7Y9@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_238521_1 177437.HRM2_22700 2.23e-33 133.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M88@68525|delta/epsilon subdivisions,2WIZI@28221|Deltaproteobacteria 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS_9,Sigma54_activat k59_467729_1 243231.GSU2351 2.72e-105 341.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.6 ko:K01535,ko:K12955 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.24,3.A.3.3 - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_598388_1 387093.SUN_1171 6.9e-107 309.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42PGH@68525|delta/epsilon subdivisions,2YN8W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Molybdenum cofactor biosynthesis protein mogA - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_892045_1 396595.TK90_0988 1.51e-41 150.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains zraR GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_892045_2 1049564.TevJSym_aa01830 2.07e-13 69.3 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SNU0@1236|Gammaproteobacteria 1236|Gammaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_108415_1 768671.ThimaDRAFT_1060 4.16e-71 236.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1WWJW@135613|Chromatiales 135613|Chromatiales S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_75562_1 1125863.JAFN01000001_gene2493 3.65e-21 100.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria 28221|Deltaproteobacteria C denitrification pathway cbcY - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB k59_859053_2 555079.Toce_0123 7.82e-31 112.0 COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,42GJK@68295|Thermoanaerobacterales 186801|Clostridia J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_859053_3 986075.CathTA2_2530 8.3e-93 282.0 COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,4HAE8@91061|Bacilli 91061|Bacilli J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_859053_4 481448.Minf_0685 5.75e-09 57.0 COG0089@1|root,COG0089@2|Bacteria,46WBX@74201|Verrucomicrobia,37H1F@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_859053_5 926692.AZYG01000040_gene1594 1.19e-41 147.0 COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,3WAJE@53433|Halanaerobiales 186801|Clostridia J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_859053_6 1267211.KI669560_gene1317 7e-50 167.0 COG0087@1|root,COG0087@2|Bacteria,4NEAN@976|Bacteroidetes,1IPGZ@117747|Sphingobacteriia 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_664208_1 933262.AXAM01000019_gene1087 3.83e-73 229.0 COG1145@1|root,COG1145@2|Bacteria,1PW12@1224|Proteobacteria,42MZ9@68525|delta/epsilon subdivisions,2WN0W@28221|Deltaproteobacteria,2MHYH@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Fer4_6 k59_696037_1 572480.Arnit_0532 1.76e-88 270.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,42MJ0@68525|delta/epsilon subdivisions,2YMCZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Co Zn Cd efflux system component czcD - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux,ZT_dimer k59_6328_1 1168034.FH5T_10970 3.04e-60 191.0 COG1131@1|root,COG1131@2|Bacteria,4NDV7@976|Bacteroidetes,2FN84@200643|Bacteroidia 976|Bacteroidetes V ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_6328_2 1168034.FH5T_10965 8.15e-20 84.0 COG2137@1|root,COG2137@2|Bacteria,4NSAS@976|Bacteroidetes,2FS4X@200643|Bacteroidia 976|Bacteroidetes S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_565907_1 574966.KB898650_gene493 9.55e-125 370.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XI3Y@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes glnG - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_75571_1 1270193.JARP01000006_gene1707 1.72e-33 132.0 COG4487@1|root,COG4487@2|Bacteria,4NGZ9@976|Bacteroidetes,1HZ50@117743|Flavobacteriia,2NV85@237|Flavobacterium 976|Bacteroidetes S Uncharacterized protein conserved in bacteria (DUF2130) - - - - - - - - - - - - DUF2130 k59_760761_1 1415779.JOMH01000001_gene2073 2.62e-70 233.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1X2ZN@135614|Xanthomonadales 135614|Xanthomonadales S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - - - - - - - - - - Peptidase_M48,TPR_19 k59_401705_2 1049564.TevJSym_an00750 1.51e-81 247.0 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1J5U7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis rnt GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T k59_859064_1 500153.JOEK01000002_gene168 1.5e-14 80.9 28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1022635_1 1168034.FH5T_04850 1.35e-32 116.0 COG0782@1|root,COG0782@2|Bacteria,4NNH6@976|Bacteroidetes,2FPFU@200643|Bacteroidia 976|Bacteroidetes K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_533611_1 929558.SMGD1_0707 2.27e-66 227.0 COG2911@1|root,COG2911@2|Bacteria,1NRGB@1224|Proteobacteria,42MD0@68525|delta/epsilon subdivisions,2YMIM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_173713_1 1168034.FH5T_13800 3.86e-105 327.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,2FMDB@200643|Bacteroidia 976|Bacteroidetes E homoserine dehydrogenase thrA - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_957299_1 32024.JMTI01000002_gene654 5.4e-21 97.8 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,43B2E@68525|delta/epsilon subdivisions,2YN33@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M peptidylprolyl isomerase peb4 - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_41140_1 1500893.JQNB01000001_gene150 7.33e-16 77.4 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1X3ZE@135614|Xanthomonadales 135614|Xanthomonadales KL Helicase yoaA - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2,ResIII k59_41140_2 160488.PP_4682 5.97e-19 87.0 COG3071@1|root,COG3071@2|Bacteria,1N8NX@1224|Proteobacteria,1SC7X@1236|Gammaproteobacteria,1YVDQ@136845|Pseudomonas putida group 1236|Gammaproteobacteria H COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16 k59_238561_1 1227739.Hsw_0176 2.44e-64 216.0 COG3829@1|root,COG3829@2|Bacteria,4PM5Y@976|Bacteroidetes,47Y6R@768503|Cytophagia 976|Bacteroidetes KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - GAF,GAF_2,HTH_8,PAS_9,Response_reg,Sigma54_activat,cNMP_binding k59_696065_1 2340.JV46_25530 3.84e-35 133.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,1J5R3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Phage integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_696065_2 644966.Tmar_0713 2.91e-13 69.3 COG1569@1|root,COG1569@2|Bacteria,1VCZ6@1239|Firmicutes,24Q32@186801|Clostridia 186801|Clostridia S PIN domain - - - - - - - - - - - - PIN_3 k59_728316_1 1168034.FH5T_16820 3.42e-164 472.0 COG1408@1|root,COG1408@2|Bacteria,4NFCH@976|Bacteroidetes,2FP07@200643|Bacteroidia 976|Bacteroidetes S Ser Thr phosphatase family protein - - - ko:K07098 - - - - ko00000 - - - Metallophos,Metallophos_2 k59_433907_1 298655.KI912266_gene1355 2.23e-40 153.0 COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4ETCD@85013|Frankiales 201174|Actinobacteria S Laminin G domain wcoG - - - - - - - - - - - Laminin_G_3,PKD k59_337698_1 425104.Ssed_0888 6.74e-32 128.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q8ZE@267890|Shewanellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_892100_1 1038859.AXAU01000003_gene6153 2.47e-12 68.9 COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2TREX@28211|Alphaproteobacteria,3JSKS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Protein of unknown function (DUF3300) - - - - - - - - - - - - DUF3300 k59_892103_1 83406.HDN1F_28520 1.4e-43 164.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1J527@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the GPAT DAPAT family plsB GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - iECs_1301.ECs5024,iG2583_1286.G2583_4866 Acyltransferase k59_990784_2 749222.Nitsa_1256 1.73e-42 155.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1R5RS@1224|Proteobacteria,42M3K@68525|delta/epsilon subdivisions,2YN6E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM biotin lipoyl attachment domain-containing protein pycB - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_598451_1 396588.Tgr7_1990 1.41e-103 331.0 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg k59_369811_2 273121.WS1486 9.07e-07 49.7 COG1193@1|root,COG1193@2|Bacteria,1QUJI@1224|Proteobacteria,42P7P@68525|delta/epsilon subdivisions,2YMFB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0000018,GO:0008150,GO:0009892,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0080090 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_238575_1 1196322.A370_02700 4.71e-86 264.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,36E13@31979|Clostridiaceae 186801|Clostridia CH D-isomer specific 2-hydroxyacid dehydrogenase hprA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_206246_1 1121430.JMLG01000006_gene1776 6.93e-17 85.5 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,26000@186807|Peptococcaceae 186801|Clostridia F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31,3.5.4.40 ko:K12960,ko:K20810 ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110 - R09660,R10695 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_41585_1 1168034.FH5T_04015 1.44e-198 613.0 COG4797@1|root,COG4797@2|Bacteria,4PKQS@976|Bacteroidetes,2FP69@200643|Bacteroidia 976|Bacteroidetes S Motility related/secretion protein sprA - - - - - - - - - - - SprA_N k59_957843_3 1219080.VEZ01S_37_00560 3.95e-20 90.9 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XUAZ@135623|Vibrionales 135623|Vibrionales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_303502_1 1469245.JFBG01000023_gene1270 2.72e-76 248.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1X2Q6@135613|Chromatiales 135613|Chromatiales C SNARE associated Golgi protein - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_142131_1 1168034.FH5T_13450 3.98e-28 105.0 2CKSR@1|root,30RNP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_142131_2 1408473.JHXO01000006_gene1257 1.24e-65 211.0 COG0657@1|root,COG0657@2|Bacteria,4NGAF@976|Bacteroidetes,2FSWW@200643|Bacteroidia 976|Bacteroidetes I Protein of unknown function (DUF1460) - - - - - - - - - - - - DUF1460 k59_631717_1 457398.HMPREF0326_01490 1.32e-18 82.4 COG0338@1|root,COG0338@2|Bacteria,1P85S@1224|Proteobacteria,42MJQ@68525|delta/epsilon subdivisions,2WM98@28221|Deltaproteobacteria,2MB81@213115|Desulfovibrionales 28221|Deltaproteobacteria L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12,Peptidase_S78_2 k59_631717_2 1029823.AFIE01000021_gene3178 2.51e-30 116.0 2DMKC@1|root,32S64@2|Bacteria,1N3QF@1224|Proteobacteria,1SBRT@1236|Gammaproteobacteria,3NNUI@468|Moraxellaceae 1236|Gammaproteobacteria S HNH endonuclease - - - - - - - - - - - - HNH_3 k59_1023191_1 1122917.KB899672_gene818 6.59e-31 126.0 COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,4HB9Q@91061|Bacilli,26SER@186822|Paenibacillaceae 91061|Bacilli D membrane - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_728796_1 637390.AFOH01000067_gene1134 1.22e-42 140.0 COG2161@1|root,COG2161@2|Bacteria,1N07B@1224|Proteobacteria,1S90V@1236|Gammaproteobacteria,2NDAE@225057|Acidithiobacillales 225057|Acidithiobacillales D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox k59_728796_2 555778.Hneap_0074 1.78e-45 147.0 COG4115@1|root,COG4115@2|Bacteria,1N0WH@1224|Proteobacteria,1S8ZF@1236|Gammaproteobacteria,1WYYK@135613|Chromatiales 135613|Chromatiales S TIGRFAM Addiction module toxin, Txe YoeB - - - - - - - - - - - - YoeB_toxin k59_957863_1 1111479.AXAR01000005_gene584 8.04e-126 394.0 COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,4HAWB@91061|Bacilli,2780S@186823|Alicyclobacillaceae 91061|Bacilli J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_631722_1 1205680.CAKO01000042_gene5361 7.53e-96 286.0 COG0179@1|root,COG0179@2|Bacteria,1QUQP@1224|Proteobacteria 1224|Proteobacteria Q Fumarylacetoacetate (FAA) hydrolase MA20_15150 - - - - - - - - - - - DUF2437,FAA_hydrolase k59_761430_1 675813.VIB_002962 1.27e-99 303.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,1S7XK@1236|Gammaproteobacteria,1Y33H@135623|Vibrionales 135623|Vibrionales L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,zf-IS66 k59_892673_1 572544.Ilyop_0198 5.11e-73 232.0 COG1109@1|root,COG1109@2|Bacteria,3788E@32066|Fusobacteria 32066|Fusobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_892673_2 572544.Ilyop_0197 1.44e-61 195.0 COG4769@1|root,COG4769@2|Bacteria,378HJ@32066|Fusobacteria 32066|Fusobacteria S Heptaprenyl diphosphate synthase component I - - 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 - R09247 RC00279 ko00000,ko00001,ko01000,ko01006 - - - Hpre_diP_synt_I k59_892673_3 572544.Ilyop_0196 2.37e-206 580.0 COG0015@1|root,COG0015@2|Bacteria,378VV@32066|Fusobacteria 32066|Fusobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_566477_1 1247726.MIM_c06570 2.72e-32 129.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2VITK@28216|Betaproteobacteria,3T25D@506|Alcaligenaceae 28216|Betaproteobacteria C Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.3.8.7,1.5.5.2 ko:K00249,ko:K00294,ko:K13821 ko00071,ko00250,ko00280,ko00330,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00250,map00280,map00330,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00245,R00707,R00708,R00924,R01175,R01253,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04444,R04445,R04751,R04754,R05051 RC00052,RC00068,RC00076,RC00080,RC00083,RC00095,RC00148,RC00216,RC00242,RC00246,RC00255 ko00000,ko00001,ko00002,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_664801_1 55601.VANGNB10_cII0498 1.7e-104 315.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1XW0E@135623|Vibrionales 135623|Vibrionales L other refs with uncharged polar side chains (S Ser or T Thr), and there are a few more such examples along the aa-chain (ex R Arg changed with H His) - - - - - - - - - - - - HTH_38,rve k59_926237_1 410359.Pcal_1311 4.26e-47 163.0 COG1064@1|root,arCOG01455@2157|Archaea,2XQ4K@28889|Crenarchaeota 28889|Crenarchaeota C Alcohol dehydrogenase zinc-binding domain protein - - 1.1.1.1 ko:K13953,ko:K18382 ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10703 RC00050,RC00087,RC00088,RC00099,RC00116,RC00545,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_76094_1 1134474.O59_004010 8.65e-24 102.0 2B1Z8@1|root,31UFT@2|Bacteria,1RHY7@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - TIR_2 k59_76094_2 331678.Cphamn1_2543 3.56e-78 258.0 COG0610@1|root,COG0610@2|Bacteria 2|Bacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_859636_1 519989.ECTPHS_13218 1.55e-83 275.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_270841_1 292415.Tbd_0587 1.46e-20 88.2 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2VQA2@28216|Betaproteobacteria,1KRPX@119069|Hydrogenophilales 119069|Hydrogenophilales O Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_270841_2 387093.SUN_1831 9.25e-77 231.0 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2YPC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q CoA-binding protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_270841_3 709032.Sulku_1439 2.44e-57 189.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2YMUR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_599054_1 1068980.ARVW01000001_gene1917 9.82e-54 179.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Chlorophyllase2 k59_501473_1 765912.Thimo_3341 3.02e-148 427.0 COG0247@1|root,COG1143@1|root,COG0247@2|Bacteria,COG1143@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1WWK6@135613|Chromatiales 135613|Chromatiales C PFAM Cysteine-rich - - - - - - - - - - - - CCG,Fer4_8 k59_1023203_1 992406.RIA_0788 1.77e-05 47.8 COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes,1HWQA@117743|Flavobacteriia 976|Bacteroidetes I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_1023203_2 469616.FMAG_00808 1.92e-23 96.3 COG0566@1|root,COG0566@2|Bacteria,3791M@32066|Fusobacteria 32066|Fusobacteria J RNA methyltransferase TrmH family - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase k59_859641_1 572546.Arcpr_1559 4.53e-23 98.2 COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,246AE@183980|Archaeoglobi 183980|Archaeoglobi J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_270846_1 1121938.AUDY01000016_gene3018 3.86e-56 185.0 COG4989@1|root,COG4989@2|Bacteria,1TQ12@1239|Firmicutes,4HA57@91061|Bacilli,3NF43@45667|Halobacillus 91061|Bacilli S Aldo/keto reductase family ycsN - - - - - - - - - - - Aldo_ket_red k59_303539_2 933262.AXAM01000011_gene1755 1.91e-38 144.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,2MJ25@213118|Desulfobacterales 28221|Deltaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Fer4_9,Pyr_redox_2 k59_926249_1 1038869.AXAN01000117_gene4541 2.98e-31 121.0 COG3547@1|root,COG3547@2|Bacteria,1PWTR@1224|Proteobacteria,2WCCG@28216|Betaproteobacteria,1K7IV@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_892689_1 1537917.JU82_03990 1.34e-111 335.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2YMY6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_599059_1 709032.Sulku_0142 3.1e-93 302.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2YMTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_599059_2 56780.SYN_00712 4.7e-70 220.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,42SI3@68525|delta/epsilon subdivisions,2WPVX@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_599059_3 545696.HOLDEFILI_03933 7.28e-18 81.6 COG0350@1|root,COG0350@2|Bacteria,1V2MB@1239|Firmicutes,3VQV9@526524|Erysipelotrichia 526524|Erysipelotrichia L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - - - - - - - - - - - DNA_binding_1,Methyltransf_1N k59_599059_4 929558.SMGD1_1144 8.24e-18 80.5 COG3038@1|root,COG3038@2|Bacteria,1NC3G@1224|Proteobacteria,42SCY@68525|delta/epsilon subdivisions,2YQ0N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_1023212_1 857087.Metme_4447 1.55e-10 61.6 COG0739@1|root,COG0739@2|Bacteria,1RIS0@1224|Proteobacteria,1S6KP@1236|Gammaproteobacteria,1XG3T@135618|Methylococcales 135618|Methylococcales M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_1023212_2 400682.PAC_15703455 4.33e-20 92.0 COG1331@1|root,KOG2244@2759|Eukaryota 2759|Eukaryota O spermatogenesis - - - - - - - - - - - - Glyco_hydro_9,Thioredox_DsbH k59_375304_1 1168034.FH5T_17005 3.43e-82 252.0 COG0131@1|root,COG0241@1|root,COG0131@2|Bacteria,COG0241@2|Bacteria,4NENP@976|Bacteroidetes,2FP1T@200643|Bacteroidia 976|Bacteroidetes E belongs to the imidazoleglycerol-phosphate dehydratase family hisB GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - - Hydrolase_like,IGPD,PNK3P k59_796611_1 926550.CLDAP_11030 1.36e-49 168.0 COG0601@1|root,COG0601@2|Bacteria 2|Bacteria P nitrogen compound transport appB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_80817_1 572477.Alvin_0720 6.45e-59 200.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales 135613|Chromatiales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_147617_1 1168034.FH5T_14455 8.8e-163 473.0 COG1132@1|root,COG1132@2|Bacteria,4NE2D@976|Bacteroidetes,2FMUK@200643|Bacteroidia 976|Bacteroidetes V ABC transporter, ATP-binding protein msbA - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_571593_1 1121127.JAFA01000009_gene7074 1.41e-61 204.0 COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,2VKTF@28216|Betaproteobacteria,1K4RY@119060|Burkholderiaceae 28216|Betaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_407567_1 1537917.JU82_06055 3.02e-67 213.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42MF8@68525|delta/epsilon subdivisions,2YN61@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_407567_2 1537917.JU82_06100 5.75e-80 244.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,42PD0@68525|delta/epsilon subdivisions,2YNP2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG0396 ABC-type transport system involved in Fe-S cluster assembly ATPase component - - - - - - - - - - - - ABC_tran k59_309022_1 439235.Dalk_4112 2.99e-107 335.0 COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,2MHW1@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - DUF2344,Radical_SAM k59_767346_1 1430440.MGMSRv2_1428 2.14e-61 197.0 COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria 1224|Proteobacteria C Pfam cytochrome c - - - - - - - - - - - - Cytochrom_C k59_10443_2 563040.Saut_0686 5.81e-15 74.3 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2YMW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_275477_1 1397666.RS24_00348 3.88e-14 81.3 COG1629@1|root,COG4771@2|Bacteria,1R533@1224|Proteobacteria,2TVP0@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_997464_1 1168034.FH5T_08430 3.11e-112 330.0 COG0379@1|root,COG0379@2|Bacteria,4NDVX@976|Bacteroidetes,2FMT0@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_508127_1 1211114.ALIP01000104_gene976 1.68e-18 86.3 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1X3X2@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_508127_2 85643.Tmz1t_3434 1.39e-18 80.1 COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,2KWVG@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_508127_3 1049564.TevJSym_aj00380 5.6e-15 73.2 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1J4C3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_408262_2 2340.JV46_10700 1.21e-72 223.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT k59_344517_1 1454004.AW11_01429 1.82e-56 180.0 COG0221@1|root,COG0221@2|Bacteria,1RGCP@1224|Proteobacteria,2VRVG@28216|Betaproteobacteria 28216|Betaproteobacteria C Inorganic pyrophosphatase - - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_344517_2 1248232.BANQ01000032_gene3828 1.8e-39 135.0 COG3152@1|root,COG3152@2|Bacteria,1MZJ4@1224|Proteobacteria,1SA1N@1236|Gammaproteobacteria,1XY7E@135623|Vibrionales 135623|Vibrionales S membrane - - - - - - - - - - - - DUF805 k59_702876_1 1122194.AUHU01000013_gene755 1.85e-12 65.5 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,466GK@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_702876_2 1123073.KB899243_gene703 8.65e-39 134.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1X6H0@135614|Xanthomonadales 135614|Xanthomonadales J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_1028989_1 387093.SUN_0859 1.82e-31 120.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - ko:K12980 - - - - ko00000,ko01005 - - - OMP_b-brl k59_898923_2 511.JT27_04570 4.91e-11 62.8 COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,3T3VA@506|Alcaligenaceae 28216|Betaproteobacteria D Sporulation related domain ftsN - - - - - - - - - - - SPOR k59_408282_1 76114.ebA1142 5.66e-34 127.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,2KUFJ@206389|Rhodocyclales 206389|Rhodocyclales S phosphotransferase related to Ser Thr protein kinases - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_11126_1 1215092.PA6_047_00180 1.33e-53 194.0 COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1MVGH@1224|Proteobacteria,1RQXN@1236|Gammaproteobacteria,1YK20@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Domain of unknown function (DUF1998) - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_344542_1 582899.Hden_0691 5.88e-128 371.0 COG1148@1|root,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria 28211|Alphaproteobacteria C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored,Pyr_redox_2 k59_572369_2 290315.Clim_2069 3.18e-73 241.0 COG2989@1|root,COG2989@2|Bacteria,1FEJK@1090|Chlorobi 1090|Chlorobi S PFAM Peptidoglycan-binding domain 1 protein - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_376021_1 937777.Deipe_1222 1.2e-20 89.0 COG2095@1|root,COG2095@2|Bacteria,1WJXY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus U UPF0056 membrane protein marC - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_376021_2 1038860.AXAP01000128_gene3947 3.08e-23 95.1 COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2UFDN@28211|Alphaproteobacteria,3JYII@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_213304_1 1168034.FH5T_00655 2.06e-126 390.0 2CDRA@1|root,2Z7QN@2|Bacteria,4NHVB@976|Bacteroidetes,2FQ9D@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_213304_2 385682.AFSL01000089_gene922 2.73e-47 169.0 COG3507@1|root,COG3507@2|Bacteria,4NI92@976|Bacteroidetes,2G2P8@200643|Bacteroidia 976|Bacteroidetes G F5 8 type C domain - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_43,Laminin_G_3 k59_932152_1 1049564.TevJSym_bk00120 4.34e-31 115.0 COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria 1236|Gammaproteobacteria T dksA traR - - - - - - - - - - - - zf-dskA_traR k59_440516_1 96561.Dole_0847 3.88e-68 226.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2MHKU@213118|Desulfobacterales 28221|Deltaproteobacteria G Alpha amylase, C-terminal all-beta domain glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_47179_1 869213.JCM21142_1580 9.95e-116 348.0 COG2407@1|root,COG2407@2|Bacteria,4NHWI@976|Bacteroidetes,47TTR@768503|Cytophagia 976|Bacteroidetes G L-fucose isomerase, first N-terminal domain fucI - 5.3.1.25,5.3.1.3 ko:K01818 ko00051,ko01120,map00051,map01120 - R03163 RC00434 ko00000,ko00001,ko01000 - - - Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2 k59_180897_1 439235.Dalk_1398 8.15e-75 234.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,42S6T@68525|delta/epsilon subdivisions,2WSCK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Bile acid sodium symporter yocS - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_508161_1 1122130.AUHN01000005_gene2300 1.23e-14 76.3 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family calB - 1.2.1.3,1.2.99.10 ko:K00128,ko:K22445 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_508161_2 96561.Dole_1905 2.68e-35 128.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,42W8P@68525|delta/epsilon subdivisions,2WRV4@28221|Deltaproteobacteria,2MKN4@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM NUDIX hydrolase nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_637963_1 768671.ThimaDRAFT_0549 1.5e-24 102.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1WX2Y@135613|Chromatiales 135613|Chromatiales I synthetase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_637963_2 1317118.ATO8_00960 2.91e-33 117.0 COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,2UC3P@28211|Alphaproteobacteria,4KMYR@93682|Roseivivax 28211|Alphaproteobacteria S Domain of unknown function (DUF4212) - - - - - - - - - - - - DUF4212 k59_865662_1 1173029.JH980292_gene681 3.63e-49 161.0 COG0432@1|root,COG0432@2|Bacteria,1G5WN@1117|Cyanobacteria,1HB6T@1150|Oscillatoriales 1117|Cyanobacteria S Secondary thiamine-phosphate synthase enzyme - - - - - - - - - - - - UPF0047 k59_865665_1 1168034.FH5T_11520 1.13e-71 224.0 COG0392@1|root,COG0392@2|Bacteria,4NGPD@976|Bacteroidetes,2FP5P@200643|Bacteroidia 976|Bacteroidetes S Psort location CytoplasmicMembrane, score 10.00 - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_244972_1 526218.Sterm_1144 1.26e-38 140.0 COG1660@1|root,COG1660@2|Bacteria,378VH@32066|Fusobacteria 32066|Fusobacteria S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_11152_1 1116472.MGMO_47c00190 2.01e-08 58.5 COG0664@1|root,COG0664@2|Bacteria,1PHCV@1224|Proteobacteria,1RXUG@1236|Gammaproteobacteria,1XGT4@135618|Methylococcales 2|Bacteria K Cyclic nucleotide-monophosphate binding domain - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_344572_2 266809.PM03_00820 1.08e-06 53.1 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria 28211|Alphaproteobacteria U COG0457 FOG TPR repeat MA20_42300 - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_671059_1 1123514.KB905899_gene1994 1.55e-40 142.0 COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,1S0KZ@1236|Gammaproteobacteria,463AF@72273|Thiotrichales 72273|Thiotrichales S Uncharacterised ACR, YagE family COG1723 - - - - - - - - - - - - DUF155 k59_114673_1 204669.Acid345_2659 1.84e-23 98.6 2BNC6@1|root,32GZV@2|Bacteria,3Y8TE@57723|Acidobacteria 57723|Acidobacteria S Gluconate 2-dehydrogenase subunit 3 - - 1.1.99.3 ko:K06152 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - Gluconate_2-dh3 k59_276228_1 99598.Cal7507_0914 3.48e-66 221.0 COG0342@1|root,COG0342@2|Bacteria,1G053@1117|Cyanobacteria,1HK69@1161|Nostocales 1117|Cyanobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_276228_2 580340.Tlie_0613 7.52e-41 150.0 COG0341@1|root,COG0341@2|Bacteria,3TABF@508458|Synergistetes 508458|Synergistetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_833527_1 1121396.KB893051_gene3461 6.43e-82 254.0 COG0004@1|root,COG0004@2|Bacteria,1R50W@1224|Proteobacteria,42PKR@68525|delta/epsilon subdivisions,2WM8P@28221|Deltaproteobacteria,2MII5@213118|Desulfobacterales 28221|Deltaproteobacteria P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_440536_1 1042377.AFPJ01000032_gene2692 1.72e-22 97.8 2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,467DY@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_440536_2 1122211.JMLW01000011_gene137 1.5e-28 109.0 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,1XKJK@135619|Oceanospirillales 135619|Oceanospirillales M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_440536_3 631362.Thi970DRAFT_04205 1.07e-15 72.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1WYPN@135613|Chromatiales 135613|Chromatiales C Iron--sulfur cluster insertion protein erpA erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_114674_1 177437.HRM2_21200 4.06e-56 193.0 COG5337@1|root,COG5337@2|Bacteria,1QCJ4@1224|Proteobacteria,42QGZ@68525|delta/epsilon subdivisions,2WKE6@28221|Deltaproteobacteria,2MKTV@213118|Desulfobacterales 28221|Deltaproteobacteria M CotH kinase protein - - - - - - - - - - - - CotH k59_768053_1 367737.Abu_1651 1.36e-51 175.0 COG3500@1|root,COG3500@2|Bacteria,1MXT8@1224|Proteobacteria,42U7Z@68525|delta/epsilon subdivisions,2YPVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Phage late control gene D protein (GPD) - - - ko:K06905 - - - - ko00000 - - - Phage_GPD k59_473514_1 526218.Sterm_2669 0.0 1229.0 COG0458@1|root,COG0458@2|Bacteria,378K3@32066|Fusobacteria 32066|Fusobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_473514_2 469617.FUAG_01696 1.03e-118 353.0 COG0540@1|root,COG0540@2|Bacteria,379FQ@32066|Fusobacteria 32066|Fusobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_473514_3 585394.RHOM_04025 1.89e-49 170.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_473514_4 1319815.HMPREF0202_02488 4.39e-167 473.0 COG0167@1|root,COG0167@2|Bacteria,3787T@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_473514_5 759914.BP951000_1071 4.25e-88 275.0 COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2J744@203691|Spirochaetes 203691|Spirochaetes F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10,4.1.1.23 ko:K00762,ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965,R01870 RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase,Pribosyltran k59_473514_6 888055.HMPREF9015_00591 7.6e-32 124.0 COG0044@1|root,COG0044@2|Bacteria,379AR@32066|Fusobacteria 32066|Fusobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_997553_1 582402.Hbal_1085 5.57e-25 100.0 2DBQG@1|root,2ZADX@2|Bacteria,1R8XD@1224|Proteobacteria,2U62B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 k59_997553_2 760192.Halhy_6270 1.83e-14 77.4 COG1073@1|root,COG4409@1|root,COG1073@2|Bacteria,COG4409@2|Bacteria,4NFNK@976|Bacteroidetes,1J0RH@117747|Sphingobacteriia 976|Bacteroidetes G BNR repeat-like domain - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - BNR_2 k59_605556_1 983545.Glaag_0540 9.36e-25 98.2 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,465E3@72275|Alteromonadaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_605556_2 395493.BegalDRAFT_2625 2.68e-61 189.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,1S3QX@1236|Gammaproteobacteria,460QJ@72273|Thiotrichales 72273|Thiotrichales J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_440555_1 1168034.FH5T_03165 8.94e-87 261.0 COG0483@1|root,COG0483@2|Bacteria,4NI6D@976|Bacteroidetes,2FNAK@200643|Bacteroidia 976|Bacteroidetes G Psort location Cytoplasmic, score suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_1029046_1 272943.RSP_3539 4.82e-17 90.1 COG2931@1|root,COG3188@1|root,COG2931@2|Bacteria,COG3188@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1FCQD@1060|Rhodobacter 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - HemolysinCabind,PPC,Peptidase_M10_C k59_865703_1 1231391.AMZF01000026_gene203 5.14e-85 271.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,3T1G7@506|Alcaligenaceae 28216|Betaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_638011_1 1168034.FH5T_15130 1.41e-87 271.0 COG2755@1|root,COG2755@2|Bacteria,4NHT6@976|Bacteroidetes,2G37X@200643|Bacteroidia 976|Bacteroidetes E lipolytic protein G-D-S-L family - - - - - - - - - - - - Lipase_GDSL,Lipase_GDSL_2 k59_47229_1 1168289.AJKI01000011_gene575 1.19e-53 189.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,2FNH9@200643|Bacteroidia,3XJ8U@558415|Marinilabiliaceae 976|Bacteroidetes E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_702939_1 1123368.AUIS01000006_gene590 1.03e-36 129.0 2BKU0@1|root,32FA8@2|Bacteria,1RJX5@1224|Proteobacteria,1SJ45@1236|Gammaproteobacteria,2NCXG@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_702939_2 1122185.N792_04310 1.14e-17 80.5 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1X4KC@135614|Xanthomonadales 135614|Xanthomonadales L Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis rnt GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T k59_309754_1 1049564.TevJSym_bf00220 2.39e-144 421.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1J707@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Metal dependent phosphohydrolases with conserved 'HD' motif. dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_81657_2 563040.Saut_1743 6.08e-35 127.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2YMWV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_676742_1 1122134.KB893650_gene985 1.38e-15 81.6 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria,1XPKH@135619|Oceanospirillales 135619|Oceanospirillales C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - - k59_218665_1 1249480.B649_11805 3.83e-76 230.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,42QPX@68525|delta/epsilon subdivisions,2YNW3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_250392_1 1123326.JFBL01000017_gene2305 5.19e-60 204.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions 1224|Proteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.10.3.10,1.9.3.1 ko:K02275,ko:K02297 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6 - - COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3 k59_610730_1 387093.SUN_0512 3.16e-109 327.0 COG1143@1|root,COG1145@1|root,COG1143@2|Bacteria,COG1145@2|Bacteria,1N7HT@1224|Proteobacteria,42RFF@68525|delta/epsilon subdivisions,2YP9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 k59_120237_1 768671.ThimaDRAFT_0077 9.42e-61 201.0 COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria,1WXDD@135613|Chromatiales 135613|Chromatiales CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - Glutaredoxin k59_16668_1 240292.Ava_1652 3.67e-88 266.0 COG4122@1|root,COG4122@2|Bacteria,1G2Y6@1117|Cyanobacteria,1HK98@1161|Nostocales 1117|Cyanobacteria S O-methyltransferase - - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 k59_16668_2 349521.HCH_01466 0.0 1276.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH3T@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_16668_3 349521.HCH_01465 5.16e-119 360.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,1XK00@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_16668_5 1121035.AUCH01000023_gene3429 9.16e-67 223.0 COG5266@1|root,COG5266@2|Bacteria,1RJHN@1224|Proteobacteria,2W2JQ@28216|Betaproteobacteria 28216|Betaproteobacteria P PFAM Nickel transport complex, NikM subunit, transmembrane - - - - - - - - - - - - - k59_16668_6 1121035.AUCH01000023_gene3428 5.11e-171 484.0 COG0348@1|root,COG0348@2|Bacteria,1MY5M@1224|Proteobacteria,2VH7V@28216|Betaproteobacteria,2KXJC@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S binding domain - - - - - - - - - - - - FMN_bind,Fer4_10,Fer4_5 k59_16668_7 395494.Galf_2622 8e-219 614.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2VV78@28216|Betaproteobacteria 28216|Betaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_16668_8 395494.Galf_2621 7.32e-152 431.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,2VSQQ@28216|Betaproteobacteria 28216|Betaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG k59_16668_9 395494.Galf_2620 6.57e-67 213.0 COG4232@1|root,COG4232@2|Bacteria,1N8UG@1224|Proteobacteria,2VSTK@28216|Betaproteobacteria 28216|Betaproteobacteria CO Cytochrome C biogenesis protein transmembrane region - - - - - - - - - - - - DsbD_2 k59_16668_10 765913.ThidrDRAFT_3386 4.31e-257 718.0 COG0119@1|root,COG0119@2|Bacteria,1R7YB@1224|Proteobacteria,1RQB8@1236|Gammaproteobacteria,1WX74@135613|Chromatiales 135613|Chromatiales E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.1.182 ko:K09011 ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230 M00535 R07399 RC00004,RC01205 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_16668_11 1249627.D779_1947 2.17e-209 593.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,1WWQC@135613|Chromatiales 135613|Chromatiales E TIGRFAM Threonine synthase - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_synth_N k59_16668_12 2340.JV46_26360 4.2e-25 105.0 COG3203@1|root,COG3203@2|Bacteria,1RH1J@1224|Proteobacteria,1S06S@1236|Gammaproteobacteria,1J68K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M membrane - - - - - - - - - - - - Porin_4 k59_838871_1 1131451.O1K_06767 1.69e-50 172.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1X46W@135614|Xanthomonadales 135614|Xanthomonadales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_545397_1 1248916.ANFY01000003_gene929 5.09e-45 163.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TQRF@28211|Alphaproteobacteria,2KD3V@204457|Sphingomonadales 204457|Sphingomonadales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1034236_1 1049564.TevJSym_bn00140 2.13e-81 256.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1J8GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Amidohydrolase family pyrC - 3.5.2.3,3.5.2.5 ko:K01465,ko:K01466 ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120 M00051,M00546 R01993,R02425 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_773450_1 1049564.TevJSym_bw00090 3.35e-306 852.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1J5D0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KL HELICc2 yoaA GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_773450_2 1049564.TevJSym_bw00100 1.06e-80 243.0 2C20N@1|root,32SGJ@2|Bacteria,1N3M9@1224|Proteobacteria,1S9VG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_773450_4 765911.Thivi_3348 1.31e-25 107.0 COG0457@1|root,COG0457@2|Bacteria,1N3T7@1224|Proteobacteria,1SFI0@1236|Gammaproteobacteria,1WY1U@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 k59_773450_5 765912.Thimo_2101 1.46e-289 823.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1WXN2@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) - - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_773450_6 317025.Tcr_1170 1.76e-209 590.0 COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,46027@72273|Thiotrichales 72273|Thiotrichales S PFAM Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_773450_7 489825.LYNGBM3L_01970 3.21e-158 471.0 COG0659@1|root,COG0659@2|Bacteria,1G1F1@1117|Cyanobacteria,1H92U@1150|Oscillatoriales 1117|Cyanobacteria P Sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_773450_8 1101195.Meth11DRAFT_1574 1.76e-55 176.0 2E103@1|root,32WG8@2|Bacteria,1N3U5@1224|Proteobacteria,2W83Y@28216|Betaproteobacteria,2KNTZ@206350|Nitrosomonadales 206350|Nitrosomonadales - - - - - - - - - - - - - - - k59_773450_9 331678.Cphamn1_0910 1.62e-11 61.6 COG2261@1|root,COG2261@2|Bacteria 2|Bacteria S Transglycosylase associated protein - - - - - - - - - - - - Transgly_assoc k59_773450_10 395493.BegalDRAFT_1360 2.37e-36 141.0 COG4255@1|root,COG4255@2|Bacteria,1RA9X@1224|Proteobacteria,1SBFD@1236|Gammaproteobacteria,461AX@72273|Thiotrichales 72273|Thiotrichales S Protein conserved in bacteria - - - - - - - - - - - - - k59_773450_11 768671.ThimaDRAFT_3755 1.52e-49 170.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_513689_2 765912.Thimo_3510 1.49e-18 84.7 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_1002907_2 572544.Ilyop_1277 4.42e-206 583.0 COG2265@1|root,COG2265@2|Bacteria,378EH@32066|Fusobacteria 32066|Fusobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_1002907_3 572544.Ilyop_1276 1.35e-81 248.0 COG0344@1|root,COG0344@2|Bacteria,379CX@32066|Fusobacteria 32066|Fusobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_1002907_4 572544.Ilyop_1275 2.36e-81 251.0 COG0240@1|root,COG0240@2|Bacteria,378MQ@32066|Fusobacteria 32066|Fusobacteria I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_610767_1 1157708.KB907462_gene885 2.38e-86 269.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VSBW@28216|Betaproteobacteria,4AGV6@80864|Comamonadaceae 28216|Betaproteobacteria M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_773456_1 1121912.AUHD01000004_gene1976 0.000251 48.1 COG1305@1|root,COG1305@2|Bacteria,4NGQG@976|Bacteroidetes,1HYNE@117743|Flavobacteriia 976|Bacteroidetes E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core k59_610772_1 385682.AFSL01000008_gene2622 1.49e-70 236.0 COG4772@1|root,COG4772@2|Bacteria,4PM03@976|Bacteroidetes,2G09Q@200643|Bacteroidia,3XIVZ@558415|Marinilabiliaceae 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_676777_1 446471.Xcel_3134 5.61e-42 150.0 COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4F3S3@85017|Promicromonosporaceae 201174|Actinobacteria F Phosphoribosylglycinamide synthetase, C domain purD GO:0008150,GO:0040007 6.3.3.1,6.3.4.13 ko:K01945,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_676777_2 926564.KI911641_gene2272 4.88e-39 133.0 COG1803@1|root,COG1803@2|Bacteria,2IMPC@201174|Actinobacteria 201174|Actinobacteria G MGS-like domain mgsA - 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - - MGS k59_1002919_2 1249480.B649_00615 6.5e-35 132.0 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2YN3X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the ompA family cadF - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA k59_739686_1 626522.GCWU000325_01847 5.93e-32 124.0 2DQP2@1|root,337VD@2|Bacteria,4PNMR@976|Bacteroidetes,2G0VA@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_676784_1 1537917.JU82_02850 3.73e-86 268.0 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,42UAQ@68525|delta/epsilon subdivisions,2YRBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM Cytochrome c, class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - - k59_16714_1 547042.BACCOPRO_02633 3.91e-25 107.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,4NEKW@976|Bacteroidetes,2FM5V@200643|Bacteroidia,4AKVM@815|Bacteroidaceae 976|Bacteroidetes M Transglycosylase SLT domain mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_871009_1 1168034.FH5T_03470 3.84e-170 478.0 COG0413@1|root,COG0413@2|Bacteria,4NDX4@976|Bacteroidetes,2FNNC@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_282132_2 749222.Nitsa_2030 1.04e-22 91.7 COG2165@1|root,COG2165@2|Bacteria,1QUIP@1224|Proteobacteria,42VHZ@68525|delta/epsilon subdivisions,2YQA3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU TIGRFAM prepilin-type N-terminal cleavage methylation domain - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_578349_1 1355374.JARU01000001_gene737 1.54e-81 265.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2YMAH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the ClpA ClpB family clpB - - ko:K03694,ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_839457_1 1121405.dsmv_0314 9.9e-06 46.6 2CP6B@1|root,32SIH@2|Bacteria,1N48E@1224|Proteobacteria,42TWR@68525|delta/epsilon subdivisions,2WPZM@28221|Deltaproteobacteria,2MKFT@213118|Desulfobacterales 28221|Deltaproteobacteria S Oxaloacetate decarboxylase, gamma chain - - - - - - - - - - - - OAD_gamma k59_871555_1 1168034.FH5T_14135 5.61e-97 286.0 COG0572@1|root,COG0572@2|Bacteria,4NEEC@976|Bacteroidetes,2FNW6@200643|Bacteroidia 976|Bacteroidetes F Cytidine monophosphokinase udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK k59_871555_2 1168034.FH5T_14140 2.58e-27 101.0 COG4627@1|root,COG4627@2|Bacteria,4PMJM@976|Bacteroidetes 976|Bacteroidetes S Stress responsive A B barrel domain - - - - - - - - - - - - Dabb k59_839460_1 886379.AEWI01000005_gene963 1.85e-80 268.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,2FNH9@200643|Bacteroidia,3XJ8U@558415|Marinilabiliaceae 976|Bacteroidetes E GXGXG motif gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_677365_1 387093.SUN_2005 2.04e-82 252.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,42PJB@68525|delta/epsilon subdivisions,2YNGQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_708945_1 1121405.dsmv_1736 2.45e-31 118.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2MMXX@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_708945_2 1121405.dsmv_1980 2.74e-30 117.0 COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,42NJ1@68525|delta/epsilon subdivisions,2WJ5S@28221|Deltaproteobacteria,2MIZQ@213118|Desulfobacterales 28221|Deltaproteobacteria L Belongs to the methyltransferase superfamily rlmL - 2.1.1.173,2.1.1.264 ko:K07444,ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_53131_1 1166948.JPZL01000004_gene180 1.75e-32 115.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_514386_1 713586.KB900536_gene166 9.47e-86 259.0 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,1S4HU@1236|Gammaproteobacteria 1236|Gammaproteobacteria L 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_938166_1 713586.KB900536_gene1471 3.43e-78 242.0 COG0412@1|root,COG0412@2|Bacteria 2|Bacteria Q carboxymethylenebutenolidase activity - - 3.1.1.45,3.1.1.76 ko:K01061,ko:K22249 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_774124_1 749222.Nitsa_0438 3.36e-64 207.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2YMQZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_17419_1 1168034.FH5T_12410 1.06e-66 216.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,2FPY6@200643|Bacteroidia 976|Bacteroidetes I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - - - - - - - - - - - Carboxyl_trans k59_154318_1 762903.Pedsa_0318 2.55e-76 254.0 COG5434@1|root,COG5434@2|Bacteria,4NE4H@976|Bacteroidetes,1IWGW@117747|Sphingobacteriia 976|Bacteroidetes M Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - - k59_53149_1 563192.HMPREF0179_01205 3.88e-50 180.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2M9DU@213115|Desulfovibrionales 28221|Deltaproteobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_839479_1 1121405.dsmv_3220 6.4e-75 236.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria,2MHN5@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3198 AA_kinase,PUA k59_120773_4 1217705.F900_02197 8.8e-43 170.0 COG0419@1|root,COG0419@2|Bacteria,1R8F1@1224|Proteobacteria,1RQ6D@1236|Gammaproteobacteria,3NS6E@468|Moraxellaceae 1236|Gammaproteobacteria L ATPase involved in DNA repair - - - - - - - - - - - - - k59_120773_5 1042163.BRLA_c005480 7.21e-41 142.0 2CC7P@1|root,32RUZ@2|Bacteria,1VKCT@1239|Firmicutes,4HWMZ@91061|Bacilli,26ZIZ@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_120773_6 1392490.JHZX01000001_gene2117 2.4e-116 347.0 28K0U@1|root,2Z9QP@2|Bacteria,4NJ60@976|Bacteroidetes,1HZYW@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - Mrr_cat k59_219438_1 745310.G432_04905 1.37e-28 117.0 2DWG9@1|root,34073@2|Bacteria,1NVA6@1224|Proteobacteria,2URJH@28211|Alphaproteobacteria,2K8JR@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_644061_1 1163617.SCD_n01348 1.39e-103 317.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VHWW@28216|Betaproteobacteria 28216|Betaproteobacteria C eight transmembrane protein EpsH - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_1034816_1 1049564.TevJSym_ba00090 6.48e-10 61.6 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1J6ZX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the skp family skp GO:0001530,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0019867,GO:0022417,GO:0022607,GO:0030288,GO:0030312,GO:0030313,GO:0031647,GO:0031975,GO:0032978,GO:0033036,GO:0034613,GO:0042597,GO:0042802,GO:0043163,GO:0043165,GO:0043170,GO:0044085,GO:0044091,GO:0044238,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0050821,GO:0051082,GO:0051179,GO:0051205,GO:0051234,GO:0051604,GO:0051641,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0070727,GO:0071704,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0097367,GO:1901564 - ko:K06142 - - - - ko00000 - - - OmpH k59_871572_1 1279017.AQYJ01000029_gene3354 4.5e-94 298.0 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - ko:K09476 ko01501,ko02020,map01501,map02020 M00746 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.1.1.1 - - Porin_4 k59_905071_1 472759.Nhal_2210 2.36e-69 227.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales 135613|Chromatiales E PFAM Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_578393_2 65672.G4TRV3 1.45e-10 67.0 KOG0266@1|root,KOG0266@2759|Eukaryota,38B6D@33154|Opisthokonta,3NZ4C@4751|Fungi,3V464@5204|Basidiomycota,224XH@155619|Agaricomycetes,3H0W7@355688|Agaricomycetes incertae sedis 4751|Fungi U WD40 repeat-like protein - - - - - - - - - - - - NACHT,WD40 k59_315666_1 1168034.FH5T_19695 7.61e-122 351.0 COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,2FQN3@200643|Bacteroidia 976|Bacteroidetes V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_17441_1 998674.ATTE01000001_gene2520 7.4e-62 196.0 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,4602B@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_17441_2 999141.GME_11342 8.91e-12 63.2 COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,1XIB2@135619|Oceanospirillales 135619|Oceanospirillales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrE - 1.6.5.8 ko:K00350 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_479646_1 1177179.A11A3_16917 1.53e-17 82.8 COG3752@1|root,COG3752@2|Bacteria,1NQQM@1224|Proteobacteria,1SMKQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1295) - - - - - - - - - - - - DUF1295 k59_414214_1 1131269.AQVV01000013_gene1742 1.9e-32 132.0 28JA7@1|root,2Z951@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CotH k59_514412_1 32042.PstZobell_11349 8.39e-146 413.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG1943 Transposase and inactivated derivatives - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_17451_1 1167006.UWK_03182 2.46e-74 228.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,42R46@68525|delta/epsilon subdivisions,2WMF2@28221|Deltaproteobacteria,2MHVF@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_388236_1 396588.Tgr7_0201 1.56e-73 235.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_388236_2 491952.Mar181_0012 5.28e-202 576.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XHSI@135619|Oceanospirillales 135619|Oceanospirillales P Trk system potassium uptake protein trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_453493_1 396588.Tgr7_1177 2.77e-135 390.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1WX6T@135613|Chromatiales 135613|Chromatiales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_779913_1 998674.ATTE01000001_gene1952 2.32e-64 218.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,462CG@72273|Thiotrichales 72273|Thiotrichales M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM k59_910407_1 1121405.dsmv_2218 8.31e-116 348.0 COG1960@1|root,COG1960@2|Bacteria,1NU73@1224|Proteobacteria,42Z96@68525|delta/epsilon subdivisions,2WTTK@28221|Deltaproteobacteria,2MN2J@213118|Desulfobacterales 28221|Deltaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_419510_2 1249480.B649_00350 1.44e-51 172.0 COG0575@1|root,COG0575@2|Bacteria,1NDQ6@1224|Proteobacteria,43DJ3@68525|delta/epsilon subdivisions,2YTJ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_160782_1 583355.Caka_0072 7.89e-09 61.2 COG0664@1|root,COG0664@2|Bacteria,46X28@74201|Verrucomicrobia,3K9HZ@414999|Opitutae 414999|Opitutae T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_844693_2 746697.Aeqsu_1056 2.91e-98 288.0 COG2128@1|root,COG2128@2|Bacteria,4NEJZ@976|Bacteroidetes,1HXPF@117743|Flavobacteriia 976|Bacteroidetes S carboxymuconolactone decarboxylase - - - - - - - - - - - - CMD k59_160785_2 864051.BurJ1DRAFT_3331 9.45e-51 162.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,2VSFJ@28216|Betaproteobacteria 28216|Betaproteobacteria P DsrC like protein - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_584488_1 990073.ATHU01000001_gene1310 0.000229 42.7 COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42N4V@68525|delta/epsilon subdivisions,2YN04@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RluA family rluA - 5.4.99.23,5.4.99.24 ko:K06179,ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_584488_2 990073.ATHU01000001_gene770 8.18e-27 101.0 COG1872@1|root,COG1872@2|Bacteria,1NGWG@1224|Proteobacteria,43EH0@68525|delta/epsilon subdivisions,2YQMQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DUF167 - - - ko:K09131 - - - - ko00000 - - - DUF167 k59_584488_3 1165841.SULAR_09569 5.5e-62 203.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2YN62@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M 3-deoxy-d-manno-octulosonic-acid transferase kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 iIT341.HP0957 Glycos_transf_N k59_1008936_1 2340.JV46_13040 2.58e-93 285.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J85H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_320733_1 402881.Plav_2312 2.37e-65 202.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,1JNVJ@119043|Rhodobiaceae 28211|Alphaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_256830_1 1348114.OM33_20805 3.3e-23 97.8 COG0189@1|root,COG0189@2|Bacteria,1MV29@1224|Proteobacteria,1SB70@1236|Gammaproteobacteria,2Q4GD@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) dcsG - - - - - - - - - - - GSH-S_ATP,RimK k59_256830_2 395965.Msil_2962 1.18e-55 176.0 COG3651@1|root,COG3651@2|Bacteria,1RH68@1224|Proteobacteria,2U9D3@28211|Alphaproteobacteria,3NB7D@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2237) - - - ko:K09966 - - - - ko00000 - - - DUF2237 k59_256830_3 159749.K0R3X0 0.000265 44.3 2DZD8@1|root,2S6XN@2759|Eukaryota,2XG2K@2836|Bacillariophyta 2759|Eukaryota - - - - - - - - - - - - - - LRR_6,tRNA_edit k59_192857_1 472759.Nhal_3020 1.19e-10 60.8 COG3514@1|root,COG3514@2|Bacteria,1N7UF@1224|Proteobacteria,1SE0J@1236|Gammaproteobacteria,1X1NQ@135613|Chromatiales 135613|Chromatiales S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_192857_2 396595.TK90_2485 2.35e-40 135.0 COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1WYU9@135613|Chromatiales 135613|Chromatiales CO Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic k59_192857_3 1056512.D515_00471 1.56e-07 53.5 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1XTX3@135623|Vibrionales 135623|Vibrionales L COG1194 A G-specific DNA glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_910419_1 754476.Q7A_2284 5.13e-07 53.1 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,45ZNE@72273|Thiotrichales 72273|Thiotrichales O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_584492_1 1121403.AUCV01000036_gene2948 3.97e-70 222.0 COG2227@1|root,COG2227@2|Bacteria,1QZT3@1224|Proteobacteria,42QXG@68525|delta/epsilon subdivisions,2WMWI@28221|Deltaproteobacteria,2MJJJ@213118|Desulfobacterales 28221|Deltaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_288267_1 572544.Ilyop_1155 6.02e-47 163.0 28I94@1|root,2Z8BU@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_388895_1 1224136.AMFN01000022_gene2031 3.39e-90 299.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,CheY-binding,H-kinase_dim,HATPase_c,Hpt k59_388895_3 1227352.C173_03789 1.86e-18 98.2 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4HAGK@91061|Bacilli,26QD7@186822|Paenibacillaceae 91061|Bacilli NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_388895_4 1041146.ATZB01000002_gene5199 3.5e-17 94.4 COG0840@1|root,COG5000@1|root,COG0840@2|Bacteria,COG5000@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,4BAS9@82115|Rhizobiaceae 28211|Alphaproteobacteria NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_388895_5 338963.Pcar_0546 1.18e-21 92.8 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X622@28221|Deltaproteobacteria,43W39@69541|Desulfuromonadales 28221|Deltaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_388895_6 926561.KB900617_gene1600 2.11e-126 374.0 COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia,3WB2N@53433|Halanaerobiales 186801|Clostridia H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_520424_1 1121957.ATVL01000010_gene597 6.35e-53 182.0 COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,47NNC@768503|Cytophagia 976|Bacteroidetes E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_552573_1 56780.SYN_02657 4.55e-50 171.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,42TG6@68525|delta/epsilon subdivisions,2WQ8T@28221|Deltaproteobacteria,2MRYG@213462|Syntrophobacterales 28221|Deltaproteobacteria L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_160804_1 1049564.TevJSym_ax00430 2.91e-84 267.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1J5MS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components atmA - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_520426_1 880072.Desac_0500 1.03e-24 103.0 COG1804@1|root,COG1804@2|Bacteria,1NWFC@1224|Proteobacteria,4300F@68525|delta/epsilon subdivisions,2X2A6@28221|Deltaproteobacteria,2MRS4@213462|Syntrophobacterales 28221|Deltaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_877340_1 983917.RGE_07200 5.42e-20 83.6 COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,2VQ50@28216|Betaproteobacteria,1KKR7@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome c norC - - ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 - - Cytochrom_C k59_877340_2 2340.JV46_05520 3.1e-231 644.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1J4TK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I norB GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0055114 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_910439_1 485917.Phep_3112 1.62e-45 167.0 COG3525@1|root,COG3525@2|Bacteria,4NK7H@976|Bacteroidetes 976|Bacteroidetes G hydrolase family 20, catalytic - - - - - - - - - - - - Glyco_hydro_20,Glyco_hydro_20b k59_844740_1 1268622.AVS7_00216 1.35e-11 65.5 2E8DE@1|root,332RW@2|Bacteria,1N96Q@1224|Proteobacteria,2VW0S@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_779970_1 96561.Dole_1984 3.29e-107 321.0 COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,42N6K@68525|delta/epsilon subdivisions,2WKFH@28221|Deltaproteobacteria,2MI37@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1343) - - - - - - - - - - - - DUF1343 k59_93609_1 717785.HYPMC_1733 2.5e-08 56.2 COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2TVAB@28211|Alphaproteobacteria 1224|Proteobacteria E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD k59_388922_1 1168034.FH5T_04895 1.62e-106 311.0 COG2003@1|root,COG2003@2|Bacteria,4NFBF@976|Bacteroidetes,2FNF3@200643|Bacteroidia 976|Bacteroidetes E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_388922_2 1168034.FH5T_04890 2.57e-44 145.0 COG0268@1|root,COG0268@2|Bacteria,4NSB1@976|Bacteroidetes,2FTW4@200643|Bacteroidia 976|Bacteroidetes J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_975667_1 717772.THIAE_10055 6.84e-82 253.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,45ZXW@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_584510_1 563040.Saut_2069 3.27e-79 255.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,42YVP@68525|delta/epsilon subdivisions,2YRC0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Conserved region in glutamate synthase - - - - - - - - - - - - Glu_synthase k59_617467_1 267608.RSc2911 6.68e-37 131.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,2VRXM@28216|Betaproteobacteria,1K7E8@119060|Burkholderiaceae 28216|Betaproteobacteria S ybak prolyl-trna synthetase associated region - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_419543_1 857087.Metme_0199 1.08e-72 228.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1XEAH@135618|Methylococcales 135618|Methylococcales I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_844742_1 563040.Saut_0918 5.45e-65 206.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,42MJK@68525|delta/epsilon subdivisions,2YMV3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0400 LYTB k59_844742_2 709032.Sulku_0884 1.47e-50 174.0 COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2YMBM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J ribosomal protein S1 rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_192870_1 187272.Mlg_1865 1.1e-106 334.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_877352_1 754476.Q7A_2553 3.8e-42 155.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria,460CE@72273|Thiotrichales 72273|Thiotrichales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_59266_1 1537917.JU82_07245 3.43e-69 226.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2YMF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_388939_1 1168034.FH5T_22130 3.41e-102 321.0 COG1452@1|root,COG1452@2|Bacteria,4NFWD@976|Bacteroidetes,2FM9F@200643|Bacteroidia 976|Bacteroidetes M Psort location OuterMembrane, score - - - - - - - - - - - - - k59_520433_1 1384056.N787_05305 6.57e-10 61.2 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1X3TR@135614|Xanthomonadales 135614|Xanthomonadales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_520433_3 935948.KE386493_gene2326 4.55e-53 191.0 COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,42ETI@68295|Thermoanaerobacterales 186801|Clostridia M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_520433_4 642492.Clole_2381 3.75e-12 67.0 COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_975682_1 269796.Rru_A0982 5.65e-13 70.5 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales 204441|Rhodospirillales P COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_225156_1 1168034.FH5T_05540 6.89e-65 204.0 COG3279@1|root,COG3279@2|Bacteria,4NF8U@976|Bacteroidetes,2FMI5@200643|Bacteroidia 976|Bacteroidetes KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_225156_2 1168034.FH5T_05535 7.92e-154 444.0 COG2972@1|root,COG2972@2|Bacteria,4NH1Q@976|Bacteroidetes,2FYBB@200643|Bacteroidia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - His_kinase k59_453569_3 1121324.CLIT_4c02010 2.4e-21 90.9 COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia 186801|Clostridia L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_910463_1 313606.M23134_02244 8.12e-17 77.8 2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,47Q5C@768503|Cytophagia 976|Bacteroidetes S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - k59_192882_1 768671.ThimaDRAFT_2778 3e-74 234.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1WVYS@135613|Chromatiales 135613|Chromatiales S PFAM von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_520441_1 1168034.FH5T_09600 3.59e-55 183.0 COG0697@1|root,COG0697@2|Bacteria,4NNBQ@976|Bacteroidetes,2FMN9@200643|Bacteroidia 976|Bacteroidetes EG Psort location CytoplasmicMembrane, score 10.00 eamA - - - - - - - - - - - EamA k59_288315_1 240015.ACP_3313 1.62e-97 291.0 COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria,2JMQ0@204432|Acidobacteriia 204432|Acidobacteriia F Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain - - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_320749_2 1122172.KB890259_gene968 1.92e-17 87.0 COG1502@1|root,COG1502@2|Bacteria 2|Bacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - - - - - - - - - - ORF6N,PLDc_2 k59_320749_3 289376.THEYE_A0296 1.51e-16 91.7 COG3505@1|root,COG3505@2|Bacteria,3J18N@40117|Nitrospirae 40117|Nitrospirae U Type IV secretion-system coupling protein DNA-binding domain - - - - - - - - - - - - TrwB_AAD_bind k59_320749_7 387093.SUN_2449 1.92e-09 62.0 2DHSC@1|root,300RJ@2|Bacteria,1Q6F2@1224|Proteobacteria,4330U@68525|delta/epsilon subdivisions,2YSKQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_320749_9 387093.SUN_2452 2.54e-160 461.0 COG4974@1|root,COG4974@2|Bacteria,1RBMG@1224|Proteobacteria,42R21@68525|delta/epsilon subdivisions,2YTEJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_225167_1 765911.Thivi_1869 3.72e-80 249.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_484712_1 582515.KR51_00003630 1.76e-06 51.2 COG0406@1|root,COG0406@2|Bacteria,1G1TS@1117|Cyanobacteria 1117|Cyanobacteria G Belongs to the phosphoglycerate mutase family gpmB - 3.1.3.3 ko:K22305 ko00260,ko00680,ko01100,ko01120,ko01130,map00260,map00680,map01100,map01120,map01130 - R00582 RC00017 ko00000,ko00001,ko01000 - - - His_Phos_1 k59_484712_2 929558.SMGD1_1342 1.37e-22 95.5 COG0368@1|root,COG0368@2|Bacteria,1N4UK@1224|Proteobacteria,42WZT@68525|delta/epsilon subdivisions,2YRS8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_1041251_1 1168034.FH5T_01625 4.33e-92 281.0 COG5557@1|root,COG5557@2|Bacteria 2|Bacteria C Polysulphide reductase, NrfD hmcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - NrfD k59_714628_1 572480.Arnit_1512 2.97e-80 251.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,42MCZ@68525|delta/epsilon subdivisions,2YNNG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M type I secretion membrane fusion protein, HlyD family - - - ko:K02022,ko:K12542 - M00330 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1 - - Biotin_lipoyl_2,HlyD_3 k59_160846_1 1168034.FH5T_02225 5.94e-41 147.0 COG3534@1|root,COG3534@2|Bacteria,4NECK@976|Bacteroidetes,2FNNB@200643|Bacteroidia 976|Bacteroidetes G Alpha-L-arabinofuranosidase domain protein abf2 - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C k59_160846_2 1048983.EL17_06765 2.17e-16 79.0 COG3534@1|root,COG3534@2|Bacteria,4NHR5@976|Bacteroidetes,47UIY@768503|Cytophagia 976|Bacteroidetes G Alpha-L-arabinofuranosidase C-terminus - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C k59_256895_1 1227739.Hsw_2678 3.32e-65 217.0 COG1501@1|root,COG1501@2|Bacteria,4PKHN@976|Bacteroidetes,47NXT@768503|Cytophagia 976|Bacteroidetes G Alpha galactosidase A - - - - - - - - - - - - Melibiase_2,NPCBM k59_649753_1 2340.JV46_16950 2.1e-153 473.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_225171_1 1042375.AFPL01000030_gene562 1.6e-107 322.0 COG0438@1|root,COG0438@2|Bacteria,1PF60@1224|Proteobacteria,1RTSV@1236|Gammaproteobacteria,46C7U@72275|Alteromonadaceae 1236|Gammaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_617516_1 1537917.JU82_07050 3.32e-40 144.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2YMCX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M lipid a biosynthesis waaM - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_321346_1 1249627.D779_1123 2.58e-78 244.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales 135613|Chromatiales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_485298_1 880073.Calab_1257 1.16e-77 257.0 COG3696@1|root,COG3696@2|Bacteria,2NNKZ@2323|unclassified Bacteria 2|Bacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_911051_1 644282.Deba_2451 1.47e-100 306.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42PMK@68525|delta/epsilon subdivisions,2WUPM@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K06446 ko00930,ko01100,ko01120,map00930,map01100,map01120 - R06943 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_976473_1 1173023.KE650771_gene5205 1.54e-39 150.0 COG0318@1|root,COG0318@2|Bacteria 2|Bacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,NAD_binding_4,PP-binding k59_296004_1 96561.Dole_2700 2.88e-13 76.3 COG0784@1|root,COG0834@1|root,COG4191@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PJW@68525|delta/epsilon subdivisions,2WJQ3@28221|Deltaproteobacteria,2MPRM@213118|Desulfobacterales 28221|Deltaproteobacteria T Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_655822_1 83406.HDN1F_29030 2.58e-155 473.0 COG0515@1|root,COG0515@2|Bacteria,1R7HM@1224|Proteobacteria,1RUIY@1236|Gammaproteobacteria 1236|Gammaproteobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - NERD,Pkinase k59_557786_1 1123255.JHYS01000009_gene2258 1.63e-77 241.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,4ADN3@80864|Comamonadaceae 28216|Betaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_263073_1 46234.ANA_C20163 2.95e-136 400.0 COG5433@1|root,COG5433@2|Bacteria,1G0VN@1117|Cyanobacteria,1HJR6@1161|Nostocales 1117|Cyanobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_622908_1 27923.ML14397a-PA 1.39e-31 130.0 COG0145@1|root,KOG1939@2759|Eukaryota,38C8D@33154|Opisthokonta,3BHEN@33208|Metazoa 33208|Metazoa E 5-oxoprolinase (ATP-hydrolyzing) activity OPLAH GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017168,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_721020_1 572480.Arnit_0053 3.12e-69 223.0 COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42N49@68525|delta/epsilon subdivisions,2YND2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA k59_296010_1 1173264.KI913950_gene4517 2.56e-39 147.0 COG3568@1|root,COG3568@2|Bacteria,1GCFN@1117|Cyanobacteria,1HHME@1150|Oscillatoriales 1117|Cyanobacteria S GH3 auxin-responsive promoter - - - - - - - - - - - - GH3 k59_394149_1 2340.JV46_16140 1.5e-59 188.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1J5V2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_753542_1 1434929.X946_3686 4.83e-109 328.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2W09K@28216|Betaproteobacteria,1KGXH@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_753542_10 743299.Acife_1499 6.99e-46 160.0 COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RR5N@1236|Gammaproteobacteria,2NDPF@225057|Acidithiobacillales 225057|Acidithiobacillales S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_1015120_1 1094980.Mpsy_2670 1.85e-77 243.0 arCOG07671@1|root,arCOG07671@2157|Archaea,2Y3EQ@28890|Euryarchaeota,2NAS8@224756|Methanomicrobia 224756|Methanomicrobia - - - - - - - - - - - - - - DDE_Tnp_1 k59_786273_1 1168034.FH5T_06470 2.43e-121 361.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,4NEBW@976|Bacteroidetes,2FMDF@200643|Bacteroidia 976|Bacteroidetes P TrkA C-terminal domain protein - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C k59_655831_2 1278306.KB906907_gene58 2.43e-44 160.0 COG0556@1|root,COG0556@2|Bacteria,3783F@32066|Fusobacteria 32066|Fusobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_851926_1 1121403.AUCV01000017_gene4454 1.04e-16 80.5 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,2MIX3@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_851926_2 472759.Nhal_2631 2.21e-69 222.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydratase - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_197984_1 384765.SIAM614_02606 3.7e-94 286.0 COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,2UBDH@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Beta-lactamase - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2,Peptidase_S13 k59_361601_1 765912.Thimo_2264 3.72e-79 253.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales 135613|Chromatiales F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_851927_1 387093.SUN_1232 2.9e-13 69.7 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2YN1V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_851927_2 944547.ABLL_1191 1.53e-23 98.2 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2YN1T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF21 - - - - - - - - - - - - CBS,DUF21 k59_296016_1 685727.REQ_04670 6.63e-54 178.0 COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4FUPK@85025|Nocardiaceae 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_296016_2 1163407.UU7_00230 3.76e-12 66.2 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1X39C@135614|Xanthomonadales 135614|Xanthomonadales S Peptidase M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_197987_1 215803.DB30_2633 2.05e-60 206.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WKYA@28221|Deltaproteobacteria,2YU1C@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_394154_2 616991.JPOO01000003_gene1392 5.29e-242 671.0 COG5297@1|root,COG5297@2|Bacteria,4NG19@976|Bacteroidetes,1I017@117743|Flavobacteriia 976|Bacteroidetes G Protein of unknown function (DUF1593) - - - - - - - - - - - - DUF1593,DUF5060 k59_34301_1 387093.SUN_1968 5.51e-18 82.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2YMPP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H riboflavin biosynthesis protein ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_34301_2 306264.CUP1218 1.92e-26 102.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,42THF@68525|delta/epsilon subdivisions,2YPXJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_590287_1 1532557.JL37_14125 1.54e-23 105.0 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,3T68C@506|Alcaligenaceae 28216|Betaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - 2.1.1.80,3.1.1.61,3.1.4.52 ko:K13243,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 R08991 RC00296 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9 k59_328905_1 570952.ATVH01000020_gene999 3.56e-08 55.5 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JPVQ@204441|Rhodospirillales 204441|Rhodospirillales E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - - - - - - - - - - - ABC_tran,TOBE_2 k59_328905_2 1123501.KB902281_gene371 1.35e-41 147.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TR41@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_459667_2 387093.SUN_1501 1.31e-19 87.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,42MA2@68525|delta/epsilon subdivisions,2YNPU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S L,D-transpeptidase catalytic domain - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_655855_1 1168034.FH5T_12225 5.94e-75 232.0 COG1052@1|root,COG1052@2|Bacteria,4NFDE@976|Bacteroidetes,2FP6R@200643|Bacteroidia 976|Bacteroidetes CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_917316_1 933262.AXAM01000007_gene2029 4.43e-108 322.0 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2MIXK@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7_1,DZR,SHOCT,zinc_ribbon_2 k59_524943_1 177437.HRM2_37440 6.27e-15 73.6 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2MIKY@213118|Desulfobacterales 28221|Deltaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_524943_2 933262.AXAM01000038_gene895 3.04e-49 164.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42R4A@68525|delta/epsilon subdivisions,2WM9Z@28221|Deltaproteobacteria,2MJDE@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM Silent information regulator protein Sir2 - - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_198006_1 641491.DND132_0848 2.84e-28 112.0 COG2045@1|root,COG2045@2|Bacteria,1N3KG@1224|Proteobacteria,431UT@68525|delta/epsilon subdivisions,2WWVQ@28221|Deltaproteobacteria,2MAMW@213115|Desulfovibrionales 28221|Deltaproteobacteria H Belongs to the ComB family - - 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp k59_394170_1 225849.swp_5080 8.35e-84 266.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,2QA8F@267890|Shewanellaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_917320_1 927658.AJUM01000034_gene410 1.21e-18 80.5 2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,2FPSJ@200643|Bacteroidia,3XJYT@558415|Marinilabiliaceae 976|Bacteroidetes S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - k59_263105_1 1168034.FH5T_05590 2.25e-211 608.0 COG0013@1|root,COG0013@2|Bacteria,4NFHW@976|Bacteroidetes,2FN1R@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_688392_1 1168034.FH5T_08625 2.73e-195 556.0 COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,2FM67@200643|Bacteroidia 976|Bacteroidetes C SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1015541_1 1226994.AMZB01000115_gene2207 3.39e-15 77.0 COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,1RZAW@1236|Gammaproteobacteria,1YFQT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Protein of unknown function (DUF2817) - - - - - - - - - - - - DUF2817 k59_1015541_2 1380393.JHVP01000009_gene1362 5.24e-06 47.0 COG4249@1|root,COG4249@2|Bacteria,2I7QS@201174|Actinobacteria 201174|Actinobacteria S KTSC domain - - - - - - - - - - - - KTSC k59_884618_1 749222.Nitsa_1865 4.64e-223 631.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,42KZC@68525|delta/epsilon subdivisions,2YM82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_982851_1 525898.Sdel_0600 5.63e-26 112.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2YMPF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_133201_1 574087.Acear_2077 9.84e-95 295.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,3WAC9@53433|Halanaerobiales 186801|Clostridia F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_558177_1 1116472.MGMO_97c00020 2.54e-15 71.2 COG0662@1|root,COG0662@2|Bacteria,1N00P@1224|Proteobacteria,1S759@1236|Gammaproteobacteria,1XFIZ@135618|Methylococcales 135618|Methylococcales G Cupin domain - - - - - - - - - - - - Cupin_2 k59_558177_2 85643.Tmz1t_1981 2.49e-75 268.0 COG4625@1|root,COG4625@2|Bacteria,1R9VZ@1224|Proteobacteria,2WEH9@28216|Betaproteobacteria,2KXNT@206389|Rhodocyclales 206389|Rhodocyclales U Autotransporter beta-domain - - - - - - - - - - - - Autotransporter k59_558177_3 85643.Tmz1t_1979 4.97e-78 245.0 COG1073@1|root,COG1073@2|Bacteria,1R8S6@1224|Proteobacteria,2VMN1@28216|Betaproteobacteria,2KYMU@206389|Rhodocyclales 206389|Rhodocyclales S Alpha/beta hydrolase family - - - - - - - - - - - - - k59_558177_5 1397527.Q670_01800 1.76e-19 83.2 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1XKKN@135619|Oceanospirillales 135619|Oceanospirillales J RNA-binding protein containing KH domain, possibly ribosomal protein yhbY - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_558177_6 1049564.TevJSym_ap00690 1.18e-102 301.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1J4TW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_558177_7 1049564.TevJSym_ap00680 0.0 990.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_558177_8 1049564.TevJSym_ap00670 7.89e-115 337.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1J4XT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3924,iPC815.YPO3501 Pterin_bind k59_558177_9 765912.Thimo_2546 1.69e-202 574.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1WW1H@135613|Chromatiales 135613|Chromatiales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_558177_10 1049564.TevJSym_ad00750 5.24e-156 442.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1J9IK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_558177_11 1049564.TevJSym_ad00760 7.16e-132 383.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1J4S7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_558177_12 1049564.TevJSym_ad00770 4.71e-21 85.5 COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,1J78B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_558177_13 2340.JV46_29190 0.0 1058.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_558177_14 631362.Thi970DRAFT_02768 6.52e-23 98.2 2B1HQ@1|root,31TYQ@2|Bacteria,1MYSE@1224|Proteobacteria,1S4AH@1236|Gammaproteobacteria,1WYG5@135613|Chromatiales 135613|Chromatiales S CNP1-like family - - - - - - - - - - - - CNP1 k59_558177_15 1149133.ppKF707_1912 0.0 1072.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1YEVJ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_558177_16 555779.Dthio_PD0982 6.21e-75 265.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2M7R7@213115|Desulfovibrionales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_558177_17 62928.azo2482 6.33e-139 473.0 COG0642@1|root,COG3829@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KVVC@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_558177_18 75379.Tint_2063 2.1e-78 238.0 2DNPN@1|root,32YG3@2|Bacteria,1N9YB@1224|Proteobacteria,2VTDM@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867 k59_558177_19 314271.RB2654_11778 5.54e-14 84.0 2A2JU@1|root,30QXU@2|Bacteria,1N7N4@1224|Proteobacteria,2TTU2@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - MA20_08245 - - - - - - - - - - - - k59_558177_20 713586.KB900536_gene852 5.64e-118 349.0 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria,1WXBJ@135613|Chromatiales 135613|Chromatiales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_558177_21 589865.DaAHT2_0034 1.78e-186 530.0 COG0057@1|root,COG0057@2|Bacteria,1R8ZT@1224|Proteobacteria,42PY6@68525|delta/epsilon subdivisions,2WKEI@28221|Deltaproteobacteria,2MII4@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_558177_22 1167006.UWK_01688 0.0 1362.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_558177_23 135651.CBN09498 6.52e-11 62.8 COG0057@1|root,COG2086@1|root,KOG0657@2759|Eukaryota,KOG3180@2759|Eukaryota,38DPH@33154|Opisthokonta,3BA6Z@33208|Metazoa,3CRFX@33213|Bilateria,40FCJ@6231|Nematoda,1KUTI@119089|Chromadorea,40XK7@6236|Rhabditida 33208|Metazoa G Glyceraldehyde-3-phosphate dehydrogenase GAPDH GO:0000003,GO:0000226,GO:0000740,GO:0000768,GO:0001669,GO:0001817,GO:0001819,GO:0001906,GO:0001907,GO:0002376,GO:0002791,GO:0002793,GO:0003006,GO:0003674,GO:0003824,GO:0004365,GO:0004857,GO:0004866,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006110,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006417,GO:0006464,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006928,GO:0006949,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007010,GO:0007017,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007286,GO:0007520,GO:0007525,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009620,GO:0009653,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010033,GO:0010466,GO:0010468,GO:0010506,GO:0010556,GO:0010558,GO:0010562,GO:0010605,GO:0010608,GO:0010629,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0014902,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016241,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016769,GO:0016903,GO:0017014,GO:0017144,GO:0017148,GO:0018119,GO:0018130,GO:0018193,GO:0018198,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019730,GO:0019752,GO:0019828,GO:0019899,GO:0019904,GO:0019953,GO:0022412,GO:0022414,GO:0030016,GO:0030017,GO:0030018,GO:0030141,GO:0030154,GO:0030162,GO:0030234,GO:0030317,GO:0030414,GO:0030808,GO:0030810,GO:0030811,GO:0030813,GO:0031090,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031331,GO:0031341,GO:0031343,GO:0031410,GO:0031430,GO:0031514,GO:0031640,GO:0031647,GO:0031672,GO:0031674,GO:0031965,GO:0031967,GO:0031975,GO:0031982,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032879,GO:0032880,GO:0032991,GO:0033500,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035605,GO:0035606,GO:0035686,GO:0035821,GO:0036126,GO:0036211,GO:0040011,GO:0042221,GO:0042325,GO:0042327,GO:0042592,GO:0042593,GO:0042692,GO:0042802,GO:0042866,GO:0042981,GO:0042995,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043086,GO:0043170,GO:0043207,GO:0043209,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043292,GO:0043412,GO:0043436,GO:0043467,GO:0043470,GO:0043891,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044441,GO:0044444,GO:0044446,GO:0044449,GO:0044463,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0044703,GO:0045087,GO:0045821,GO:0045861,GO:0045913,GO:0045935,GO:0045937,GO:0045981,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048232,GO:0048284,GO:0048468,GO:0048515,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048609,GO:0048646,GO:0048856,GO:0048869,GO:0048870,GO:0048878,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050790,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051146,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051186,GO:0051188,GO:0051193,GO:0051194,GO:0051196,GO:0051197,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0051402,GO:0051674,GO:0051701,GO:0051702,GO:0051704,GO:0051707,GO:0051709,GO:0051712,GO:0051716,GO:0051817,GO:0051818,GO:0051851,GO:0051852,GO:0051873,GO:0051883,GO:0052040,GO:0052042,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0060359,GO:0060548,GO:0061024,GO:0061025,GO:0061061,GO:0061134,GO:0061135,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0061844,GO:0062012,GO:0062013,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070887,GO:0070997,GO:0071310,GO:0071345,GO:0071346,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090174,GO:0090407,GO:0097223,GO:0097228,GO:0097452,GO:0097708,GO:0097718,GO:0097722,GO:0097729,GO:0098542,GO:0098772,GO:0099080,GO:0099081,GO:0099503,GO:0099512,GO:0120025,GO:0120038,GO:0140096,GO:1900371,GO:1900373,GO:1900542,GO:1900544,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901698,GO:1903530,GO:1903532,GO:1903578,GO:1903580,GO:1904951,GO:1990904,GO:2000112,GO:2000113,GO:2001169,GO:2001171 1.2.1.12 ko:K00134,ko:K10705 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_917826_1 909663.KI867150_gene1652 6.1e-63 205.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2WITE@28221|Deltaproteobacteria,2MQ9J@213462|Syntrophobacterales 28221|Deltaproteobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_198370_1 338966.Ppro_0816 1.82e-27 111.0 COG1459@1|root,COG1459@2|Bacteria,1R68Y@1224|Proteobacteria 1224|Proteobacteria U type II secretion system protein - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_198370_2 765912.Thimo_0649 2.78e-89 280.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1X05U@135613|Chromatiales 135613|Chromatiales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_362108_1 357808.RoseRS_2679 9.2e-146 433.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G5QP@200795|Chloroflexi,3770F@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_362108_2 1415778.JQMM01000001_gene264 9e-22 93.2 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1TH6D@1236|Gammaproteobacteria,1J9SI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Radical SAM superfamily - - - - - - - - - - - - Radical_SAM k59_852408_1 445335.CBN_2597 0.000198 45.4 COG1215@1|root,COG1215@2|Bacteria,1UFV7@1239|Firmicutes,24BR5@186801|Clostridia,36FKK@31979|Clostridiaceae 186801|Clostridia M Glycosyl transferase family 2 - - - - - - - - - - - - DUF2064,Glycos_transf_2 k59_852408_2 886882.PPSC2_c1688 9.13e-90 284.0 COG4857@1|root,COG4857@2|Bacteria,1TPHY@1239|Firmicutes,4H9QU@91061|Bacilli,26TA6@186822|Paenibacillaceae 91061|Bacilli S Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate mtnK - 2.7.1.100 ko:K00899 ko00270,ko01100,map00270,map01100 M00034 R04143 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APH k59_852408_3 1121403.AUCV01000004_gene2000 2.25e-58 196.0 COG1397@1|root,COG1397@2|Bacteria,1RA82@1224|Proteobacteria,42QPD@68525|delta/epsilon subdivisions,2WMNN@28221|Deltaproteobacteria,2MJI9@213118|Desulfobacterales 28221|Deltaproteobacteria O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_852408_4 748280.NH8B_0786 1.28e-64 209.0 2C5EX@1|root,2ZCYR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_852408_5 1123009.AUID01000007_gene711 4.24e-85 264.0 COG1957@1|root,COG1957@2|Bacteria,1UY08@1239|Firmicutes,24B2H@186801|Clostridia,26BYB@186813|unclassified Clostridiales 186801|Clostridia F Inosine-uridine preferring nucleoside hydrolase - - 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro k59_852408_6 565045.NOR51B_2073 2.23e-61 203.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1J5WZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Small-conductance mechanosensitive channel kefA - - - - - - - - - - - MS_channel k59_852408_7 269797.Mbar_A0858 3.35e-99 301.0 COG0053@1|root,arCOG01474@2157|Archaea,2XU96@28890|Euryarchaeota,2NAZZ@224756|Methanomicrobia 224756|Methanomicrobia P Dimerisation domain of Zinc Transporter - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_852408_9 1173024.KI912148_gene3379 1.58e-50 164.0 2C46F@1|root,32SRD@2|Bacteria,1GDYV@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_852408_11 370438.PTH_2423 4e-16 79.3 COG0778@1|root,COG0778@2|Bacteria,1V1BQ@1239|Firmicutes,25B0F@186801|Clostridia,262D5@186807|Peptococcaceae 186801|Clostridia C PFAM Nitroreductase - - - - - - - - - - - - Nitroreductase k59_852408_12 1443122.Z958_02415 6.37e-139 425.0 COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,25E5B@186801|Clostridia,36UMQ@31979|Clostridiaceae 186801|Clostridia C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS18410 Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_460153_1 207559.Dde_3429 3.04e-50 172.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2M8V9@213115|Desulfovibrionales 28221|Deltaproteobacteria V PFAM N-6 DNA methylase hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_460153_2 338963.Pcar_2926 6.09e-55 171.0 2DPDH@1|root,331MF@2|Bacteria,1PAC4@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_460153_3 338963.Pcar_2925 8.29e-131 390.0 COG0286@1|root,COG3465@1|root,COG0286@2|Bacteria,COG3465@2|Bacteria,1MW3A@1224|Proteobacteria,42M3B@68525|delta/epsilon subdivisions,2WKCV@28221|Deltaproteobacteria,43U20@69541|Desulfuromonadales 28221|Deltaproteobacteria V HsdM N-terminal domain - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_427075_1 1165841.SULAR_06288 3.32e-162 465.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2YMBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1055 Na H antiporter NhaD and related arsenite - - - - - - - - - - - - CitMHS k59_394602_1 1249627.D779_3084 1.04e-99 297.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1WX04@135613|Chromatiales 135613|Chromatiales D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_5024_1 1121396.KB893073_gene2962 9.9e-18 82.4 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,43AFG@68525|delta/epsilon subdivisions,2WKA9@28221|Deltaproteobacteria,2MI8V@213118|Desulfobacterales 28221|Deltaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_5024_2 765420.OSCT_2410 1.6e-27 103.0 COG0614@1|root,COG0614@2|Bacteria,2G9KR@200795|Chloroflexi,377DT@32061|Chloroflexia 32061|Chloroflexia P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_531415_1 572544.Ilyop_1147 6.1e-100 298.0 COG1897@1|root,COG1897@2|Bacteria,378EM@32066|Fusobacteria 32066|Fusobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metAA - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,HTS k59_531415_2 1121324.CLIT_11c01580 2.2e-102 316.0 COG0534@1|root,COG0534@2|Bacteria,1UYRJ@1239|Firmicutes,24FJ2@186801|Clostridia 186801|Clostridia V MatE - - - - - - - - - - - - MatE k59_563924_1 697282.Mettu_0470 5.69e-27 115.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XG54@135618|Methylococcales 135618|Methylococcales P Cation transporter/ATPase, N-terminus - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_662126_1 243365.CV_4078 2.21e-27 105.0 COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,2VUWN@28216|Betaproteobacteria,2KTVJ@206351|Neisseriales 206351|Neisseriales S Invasion gene expression up-regulator, SirB - - - - - - - - - - - - SirB k59_662126_2 1385517.N800_03880 3.86e-05 45.8 COG3213@1|root,COG3213@2|Bacteria,1PJXJ@1224|Proteobacteria,1S4J4@1236|Gammaproteobacteria,1X3TN@135614|Xanthomonadales 135614|Xanthomonadales P protein involved in response to NO - - - ko:K07234 - - - - ko00000 - - - NnrS k59_694296_1 768671.ThimaDRAFT_1752 3.69e-131 390.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_923600_2 948106.AWZT01000011_gene2029 1.68e-12 68.9 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae 28216|Betaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_73476_1 640081.Dsui_1564 3.44e-31 127.0 COG4191@1|root,COG5000@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV2U@206389|Rhodocyclales 206389|Rhodocyclales T PAS fold - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_7,PAS_8,PAS_9 k59_596119_2 390235.PputW619_0239 3.25e-47 164.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1YV5K@136845|Pseudomonas putida group 1236|Gammaproteobacteria P Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_825011_1 500633.CLOHIR_02073 8.97e-79 242.0 COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia 186801|Clostridia H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_597076_2 716544.wcw_0671 1.78e-22 97.4 COG4626@1|root,COG4626@2|Bacteria 2|Bacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_269271_1 1165841.SULAR_02538 1.86e-19 85.9 28PZQ@1|root,2ZCIX@2|Bacteria,1RA7M@1224|Proteobacteria,431D6@68525|delta/epsilon subdivisions,2YSA8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S EF hand - - - - - - - - - - - - EF-hand_5 k59_694927_1 1122135.KB893157_gene120 2.2e-20 95.5 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria 1224|Proteobacteria E asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_40099_1 572544.Ilyop_0526 5.32e-176 501.0 COG1206@1|root,COG1206@2|Bacteria,378A1@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_40099_2 291112.PAU_03312 7.53e-08 60.5 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria 1236|Gammaproteobacteria D recombinase XerD - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_int_SAM_5,Phage_integrase k59_597078_1 109760.SPPG_07427T0 1e-25 102.0 2CNPV@1|root,2S41B@2759|Eukaryota,38GK6@33154|Opisthokonta,3NZSP@4751|Fungi 4751|Fungi S Nad dependent epimerase - - - - - - - - - - - - - k59_140206_1 1168034.FH5T_22020 2.71e-79 244.0 COG2972@1|root,COG2972@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - 2TM,His_kinase k59_336389_1 1211114.ALIP01000089_gene1179 3.45e-23 100.0 COG2199@1|root,COG3706@2|Bacteria,1RBNT@1224|Proteobacteria,1S3CV@1236|Gammaproteobacteria,1XCBY@135614|Xanthomonadales 135614|Xanthomonadales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_107373_1 1449049.JONW01000005_gene1527 1.56e-29 121.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2TRS4@28211|Alphaproteobacteria,2KEZT@204458|Caulobacterales 204458|Caulobacterales M glycosyl transferase family 39 - - - - - - - - - - - - PMT,PMT_2 k59_302054_1 470145.BACCOP_00969 1.83e-46 162.0 COG4124@1|root,COG4124@2|Bacteria,4NEZG@976|Bacteroidetes,2FPAD@200643|Bacteroidia,4AM74@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 26 family - - 3.2.1.78 ko:K01218,ko:K19355 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - Glyco_hydro_26 k59_694932_1 1168034.FH5T_02890 1.43e-67 209.0 COG1595@1|root,COG1595@2|Bacteria,4NRPN@976|Bacteroidetes,2FUAJ@200643|Bacteroidia 976|Bacteroidetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_466655_1 768066.HELO_2708 4.69e-47 158.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XJQK@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_140209_1 1125863.JAFN01000001_gene772 9.57e-101 300.0 COG0330@1|root,COG0330@2|Bacteria,1R7UW@1224|Proteobacteria,42N6B@68525|delta/epsilon subdivisions,2WK9B@28221|Deltaproteobacteria 28221|Deltaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_204968_1 1173024.KI912153_gene216 9.3e-88 287.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,1JKG2@1189|Stigonemataceae 1117|Cyanobacteria C Domain of unknown function - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_107377_1 102232.GLO73106DRAFT_00011910 2.74e-13 73.9 COG0457@1|root,COG0457@2|Bacteria,1G6BT@1117|Cyanobacteria 1117|Cyanobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_564757_1 525245.HMPREF0044_1212 6.58e-34 134.0 COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4D33D@85005|Actinomycetales 201174|Actinobacteria G 4-alpha-glucanotransferase malQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_890768_1 1049564.TevJSym_ax00240 3.54e-69 233.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T1YP@1236|Gammaproteobacteria,1JC1F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - 4HB_MCP_1,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_791627_2 998674.ATTE01000001_gene2324 1.09e-49 160.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,460R0@72273|Thiotrichales 72273|Thiotrichales C Iron--sulfur cluster insertion protein erpA erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_302077_1 96561.Dole_0237 4.41e-87 283.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2MIQM@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_499608_1 1353537.TP2_00585 5.86e-41 155.0 COG0771@1|root,COG2911@1|root,COG2931@1|root,COG4625@1|root,COG4935@1|root,COG0771@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,COG4935@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - 5_nucleotid_C,DUF4214,HemolysinCabind,Hint_2 k59_107396_1 745014.OMB55_00001800 7.18e-10 58.9 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1J55G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_107396_2 1123518.ARWI01000001_gene1037 7.79e-73 226.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,460DP@72273|Thiotrichales 72273|Thiotrichales J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_107396_3 765910.MARPU_03730 1.1e-33 119.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1WYZN@135613|Chromatiales 135613|Chromatiales J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_107396_4 1380387.JADM01000014_gene4030 1.12e-07 52.8 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1XHKX@135619|Oceanospirillales 135619|Oceanospirillales J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_5609_1 1168034.FH5T_20505 1.92e-99 302.0 COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,2FMUA@200643|Bacteroidia 976|Bacteroidetes O peptidase Do htrA - - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_205001_1 1260251.SPISAL_00775 2.37e-40 147.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P sulfurtransferase - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_858054_1 387093.SUN_0280 3.94e-114 341.0 COG0842@1|root,COG0842@2|Bacteria,1NG32@1224|Proteobacteria,43APA@68525|delta/epsilon subdivisions,2YT2R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter - - - - - - - - - - - - ABC2_membrane_3 k59_858054_2 749222.Nitsa_2098 5.2e-140 414.0 COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2YMNZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G ABC transporter, ATP-binding protein - - - ko:K13926 - - - - ko00000 - - - ABC_tran k59_663064_1 765912.Thimo_0267 9.32e-33 131.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1WW3B@135613|Chromatiales 135613|Chromatiales K sigma54 specific, transcriptional regulator, Fis family - - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FleQ,HTH_8,Sigma54_activat k59_825824_1 522306.CAP2UW1_0098 2.06e-07 52.4 28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,2W0TK@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_825824_2 177437.HRM2_06600 5.03e-52 167.0 2DQN1@1|root,337Q5@2|Bacteria 2|Bacteria S Transposase zinc-binding domain - - - - - - - - - - - - Zn_Tnp_IS91 k59_107405_1 1034943.BN1094_03604 2.14e-125 371.0 COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria,1JCB8@118969|Legionellales 118969|Legionellales S MmgE/PrpD family prpD - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_499619_2 203119.Cthe_0262 7.93e-69 222.0 COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,3WH60@541000|Ruminococcaceae 186801|Clostridia E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_74510_1 439235.Dalk_1487 1.14e-54 194.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM RHS repeat-associated core - - - - - - - - - - - - AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS k59_1021979_1 395493.BegalDRAFT_1488 1.96e-79 249.0 COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria,460NT@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate pdxB - 1.1.1.290 ko:K03473 ko00750,ko01100,map00750,map01100 M00124 R04210 RC00084 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C,DUF3410 k59_597138_1 1397528.Q671_08630 1.16e-162 472.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XNSE@135619|Oceanospirillales 135619|Oceanospirillales L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_205010_1 525897.Dbac_0375 2.49e-22 89.7 COG1149@1|root,COG1149@2|Bacteria,1R0RE@1224|Proteobacteria,43CZP@68525|delta/epsilon subdivisions,2X87Z@28221|Deltaproteobacteria,2MD6N@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_7 k59_205010_2 1265505.ATUG01000002_gene1655 1.03e-41 150.0 COG1456@1|root,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,42NKF@68525|delta/epsilon subdivisions,2WJ72@28221|Deltaproteobacteria,2MJQ9@213118|Desulfobacterales 28221|Deltaproteobacteria C CO dehydrogenase/acetyl-CoA synthase delta subunit - - 2.1.1.245 ko:K00197 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD k59_336447_2 944547.ABLL_2292 9.28e-27 108.0 COG0438@1|root,COG0438@2|Bacteria,1RKCN@1224|Proteobacteria,43ANF@68525|delta/epsilon subdivisions,2YNRD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Glycosyl transferase 4-like - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_858065_1 1168034.FH5T_18255 1.3e-112 337.0 COG0534@1|root,COG0534@2|Bacteria,4NEBB@976|Bacteroidetes,2FN29@200643|Bacteroidia 976|Bacteroidetes V Mate efflux family protein norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_205011_1 290398.Csal_1077 4.85e-91 290.0 COG0507@1|root,COG1974@1|root,COG3410@1|root,COG0507@2|Bacteria,COG1974@2|Bacteria,COG3410@2|Bacteria,1R703@1224|Proteobacteria,1RY5E@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Uncharacterized conserved protein (DUF2075) - - - ko:K09384 - - - - ko00000 - - - DUF2075 k59_400581_1 504487.JCM19302_2047 1.01e-47 162.0 COG2407@1|root,COG2407@2|Bacteria,4NF0C@976|Bacteroidetes,1HYSP@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the conversion of L-arabinose to L-ribulose - - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Isome,Fucose_iso_C k59_890804_1 749222.Nitsa_1461 3.05e-28 107.0 COG3216@1|root,COG3216@2|Bacteria,1PSZW@1224|Proteobacteria,42SRF@68525|delta/epsilon subdivisions,2YPQA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_890804_2 749222.Nitsa_1343 1.16e-12 69.3 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2YN0Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_368667_1 526218.Sterm_0110 1.69e-92 282.0 COG0065@1|root,COG0065@2|Bacteria,379KW@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_368667_2 526218.Sterm_0113 3.22e-95 281.0 COG0066@1|root,COG0066@2|Bacteria,37B1Y@32066|Fusobacteria 32066|Fusobacteria H Aconitase C-terminal domain - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_368667_3 97138.C820_01103 2.36e-127 372.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,36E5F@31979|Clostridiaceae 186801|Clostridia C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_302102_1 1082705.JIBP01000017_gene547 0.000106 44.7 COG3149@1|root,COG3149@2|Bacteria,1N8VZ@1224|Proteobacteria 1224|Proteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins gspM GO:0008150,GO:0009405,GO:0044419,GO:0051704 - ko:K02462 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSM k59_302102_2 395493.BegalDRAFT_2442 1.46e-17 85.1 COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,462ER@72273|Thiotrichales 72273|Thiotrichales U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins - - - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_825843_1 646529.Desaci_1874 1.07e-14 70.5 2E6IF@1|root,3315M@2|Bacteria,1VAX0@1239|Firmicutes,24N55@186801|Clostridia 186801|Clostridia - - ortA GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 2.3.1.263 ko:K21399 - - - - ko00000,ko01000 - - - - k59_825843_2 1121017.AUFG01000003_gene3315 6.34e-24 101.0 COG0031@1|root,COG0031@2|Bacteria,2GJGN@201174|Actinobacteria 201174|Actinobacteria E Pyridoxal-phosphate dependent enzyme - - 2.3.1.263 ko:K21400 - - - - ko00000,ko01000 - - - PALP k59_956053_1 933262.AXAM01000001_gene326 2.37e-86 279.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MI4Z@213118|Desulfobacterales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_140275_1 866536.Belba_1163 4.05e-80 252.0 COG3385@1|root,COG3385@2|Bacteria,4NJC6@976|Bacteroidetes,47UVE@768503|Cytophagia 976|Bacteroidetes L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_237477_1 335543.Sfum_0418 1.65e-19 82.8 COG1259@1|root,COG1259@2|Bacteria,1RFFV@1224|Proteobacteria,42SCI@68525|delta/epsilon subdivisions,2WPWT@28221|Deltaproteobacteria,2MQHM@213462|Syntrophobacterales 28221|Deltaproteobacteria S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_237477_2 159749.K0R5V1 3.04e-20 94.4 COG0621@1|root,KOG2492@2759|Eukaryota,2XAVR@2836|Bacillariophyta 2836|Bacillariophyta T TRAM domain - - - - - - - - - - - - Radical_SAM,TRAM,UPF0004 k59_532426_1 335541.Swol_0102 2.02e-41 145.0 COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,42JQP@68298|Syntrophomonadaceae 186801|Clostridia H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_172624_1 471853.Bcav_1750 6.4e-94 284.0 COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria 201174|Actinobacteria T phosphate starvation-inducible protein PhoH phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K06217 - - - - ko00000 - - - PhoH k59_890823_1 396588.Tgr7_2778 2.31e-102 329.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_432970_1 469616.FMAG_01352 2.94e-43 153.0 COG1638@1|root,COG1638@2|Bacteria,379DA@32066|Fusobacteria 32066|Fusobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_791655_2 1047013.AQSP01000118_gene1252 2.26e-60 208.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - - - - - - - - - - - k59_269354_1 1227454.C446_15019 7.14e-05 48.5 COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,23WBW@183963|Halobacteria 183963|Halobacteria K COG0456 Acetyltransferases - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_269354_2 1033743.CAES01000016_gene2184 8.59e-06 48.5 COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,4H9U4@91061|Bacilli,26T95@186822|Paenibacillaceae 91061|Bacilli O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_336486_1 756499.Desde_2630 4.32e-20 89.4 COG0837@1|root,COG0837@2|Bacteria,1VT6V@1239|Firmicutes,24YCM@186801|Clostridia,264CG@186807|Peptococcaceae 186801|Clostridia F Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_40198_1 1168034.FH5T_12560 1.8e-36 132.0 COG2885@1|root,COG2885@2|Bacteria,4PNTG@976|Bacteroidetes,2G0Y1@200643|Bacteroidia 976|Bacteroidetes M Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 k59_40198_2 1168034.FH5T_12555 3.84e-40 144.0 COG0642@1|root,COG2205@2|Bacteria,4NEFW@976|Bacteroidetes,2FPG5@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein rprX - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_45722_1 743720.Psefu_3624 4.75e-69 221.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1YWSQ@136845|Pseudomonas putida group 1236|Gammaproteobacteria M lytic murein transglycosylase B mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_864133_1 765913.ThidrDRAFT_1728 2.66e-62 195.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales 135613|Chromatiales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_864133_2 998674.ATTE01000001_gene4273 2.72e-38 131.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,460RJ@72273|Thiotrichales 72273|Thiotrichales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_636550_1 1168034.FH5T_14655 1.69e-77 236.0 COG2825@1|root,COG2825@2|Bacteria,4NQGG@976|Bacteroidetes,2FPTR@200643|Bacteroidia 976|Bacteroidetes M membrane - - - ko:K06142 - - - - ko00000 - - - OmpH k59_308324_1 1249480.B649_09070 2.42e-118 346.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2YNZK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_701373_1 1380394.JADL01000005_gene5541 6.65e-53 182.0 COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,2TR3A@28211|Alphaproteobacteria,2JPEJ@204441|Rhodospirillales 204441|Rhodospirillales F Amidohydrolase family - - 3.5.3.13 ko:K05603 ko00340,map00340 - R02286 RC00682 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_439006_1 697282.Mettu_2076 4.37e-70 219.0 COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales 135618|Methylococcales D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 k59_406810_1 13333.ERN02618 1.33e-133 420.0 COG0052@1|root,COG0356@1|root,KOG0832@2759|Eukaryota,KOG4665@2759|Eukaryota,38964@33090|Viridiplantae,3GY32@35493|Streptophyta 35493|Streptophyta J RNA polymerase Rpb1, domain 5 rpoC2 - 2.7.7.6 ko:K02108,ko:K03046 ko00190,ko00195,ko00230,ko00240,ko01100,ko03020,map00190,map00195,map00230,map00240,map01100,map03020 M00157,M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko00194,ko01000,ko03021,ko03110,ko03400 3.A.2.1 - - RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,Ribosomal_S2 k59_604098_1 272123.Anacy_3440 1.63e-13 74.7 COG4249@1|root,COG4249@2|Bacteria 2|Bacteria S B-1 B cell differentiation - - - - - - - - - - - - FGE-sulfatase,Peptidase_C14 k59_9682_1 247633.GP2143_15026 1.07e-40 154.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1J4BX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_701378_1 1200792.AKYF01000017_gene5566 8.37e-132 429.0 COG0300@1|root,COG1020@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae 91061|Bacilli Q Non-ribosomal peptide synthetase modules and related proteins pksM3 - - ko:K13611,ko:K13614,ko:K15654 ko01054,ko02024,map01054,map02024 - - - ko00000,ko00001,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_243459_1 1094980.Mpsy_3069 3.36e-58 199.0 arCOG02362@1|root,arCOG02362@2157|Archaea,2Y7P1@28890|Euryarchaeota 28890|Euryarchaeota N methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1 k59_80109_1 1121004.ATVC01000075_gene1241 4.76e-44 158.0 COG0477@1|root,COG2814@2|Bacteria,1QV3B@1224|Proteobacteria 1224|Proteobacteria EGP Major Facilitator Superfamily - - - ko:K03535 - - - - ko00000,ko02000 2.A.1.14.1 - - MFS_1,Sugar_tr k59_146935_1 631362.Thi970DRAFT_00626 4.61e-144 421.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1WWEA@135613|Chromatiales 135613|Chromatiales C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_538961_1 1397666.RS24_00398 1.32e-67 227.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,4BPCY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_897342_1 1037409.BJ6T_83010 2.82e-85 257.0 COG3293@1|root,COG3293@2|Bacteria,1NCPP@1224|Proteobacteria 1224|Proteobacteria L Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3' - - - - - - - - - - - - DDE_Tnp_1,DUF4096 k59_930870_2 1122603.ATVI01000007_gene1476 1.14e-15 74.3 COG0386@1|root,COG0386@2|Bacteria,1RDR8@1224|Proteobacteria,1S3WV@1236|Gammaproteobacteria,1X5YI@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_343201_1 396595.TK90_2121 6.28e-84 273.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales 135613|Chromatiales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_930878_1 868595.Desca_1447 1.46e-10 69.7 COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,26144@186807|Peptococcaceae 186801|Clostridia S PFAM PHP domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_831970_1 519989.ECTPHS_03994 1.98e-87 280.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_343204_1 572547.Amico_1607 1.19e-59 193.0 COG0708@1|root,COG0708@2|Bacteria,3T9QA@508458|Synergistetes 508458|Synergistetes L exodeoxyribonuclease III xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_701397_1 396588.Tgr7_1907 5.46e-51 177.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_701397_2 1049564.TevJSym_bm00120 1.81e-05 45.8 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria 1236|Gammaproteobacteria L uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_669697_1 448385.sce6976 4.58e-16 84.3 COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria 2|Bacteria C ATP:ADP antiporter activity - - - ko:K01932,ko:K03301 - - - - ko00000,ko01000 2.A.12 - - Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC k59_1027637_1 929558.SMGD1_0642 1.98e-34 130.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2YMJY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1g k59_1027637_2 1123401.JHYQ01000017_gene2529 1.29e-38 136.0 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,4620H@72273|Thiotrichales 72273|Thiotrichales S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_795917_1 595536.ADVE02000001_gene2090 1.08e-17 87.4 COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,36Y6M@31993|Methylocystaceae 28211|Alphaproteobacteria M Penicillin-Binding Protein C-terminus Family pbpC - 2.4.1.129 ko:K05367 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - BiPBP_C,Transgly,Transpeptidase k59_179458_1 929556.Solca_2393 1.58e-09 64.3 COG1404@1|root,COG1404@2|Bacteria,4NHSQ@976|Bacteroidetes,1IWJ1@117747|Sphingobacteriia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_897357_1 1403313.AXBR01000021_gene3019 6.18e-45 158.0 COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,4HAA4@91061|Bacilli,1ZCCX@1386|Bacillus 91061|Bacilli C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_308357_1 376686.Fjoh_4090 8.44e-44 163.0 COG5434@1|root,COG5434@2|Bacteria,4NE4H@976|Bacteroidetes,1I97R@117743|Flavobacteriia,2NUPS@237|Flavobacterium 976|Bacteroidetes M Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - - k59_864174_1 1123072.AUDH01000002_gene2483 7.82e-44 155.0 COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRU9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - ko:K07046 ko00051,ko01120,map00051,map01120 - R10689 RC00537 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_80144_1 94624.Bpet0571 6.26e-61 204.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,3T24Y@506|Alcaligenaceae 28216|Betaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_211917_1 1415779.JOMH01000001_gene1179 2.38e-170 505.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1X45Q@135614|Xanthomonadales 135614|Xanthomonadales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_243491_2 1280390.CBQR020000064_gene1375 7.35e-09 56.6 COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,4HH7Z@91061|Bacilli,26XH1@186822|Paenibacillaceae 91061|Bacilli O Peroxiredoxin bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_570893_1 1279017.AQYJ01000024_gene1036 1.59e-81 256.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,4641S@72275|Alteromonadaceae 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_669712_1 452652.KSE_42440 5.64e-30 125.0 2BXK4@1|root,32XG0@2|Bacteria,2IJJ3@201174|Actinobacteria,2M39V@2063|Kitasatospora 201174|Actinobacteria - - - - - - - - - - - - - - - k59_472068_1 164328.Phyra71851 6.23e-39 132.0 COG0590@1|root,KOG1018@2759|Eukaryota,3Q9R5@4776|Peronosporales 4776|Peronosporales F MafB19-like deaminase - - 3.5.4.1 ko:K01485 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 k59_439067_1 247490.KSU1_C0191 6.33e-11 68.2 COG3419@1|root,COG3419@2|Bacteria 2|Bacteria NU Tfp pilus assembly protein tip-associated adhesin pilC - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_439067_2 1122951.ATUE01000006_gene1051 0.000776 51.2 COG4676@1|root,COG4676@2|Bacteria,1R84A@1224|Proteobacteria,1S1CN@1236|Gammaproteobacteria,3NPBP@468|Moraxellaceae 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF2135 k59_506826_1 1408473.JHXO01000012_gene457 3.43e-66 209.0 COG4544@1|root,COG4544@2|Bacteria,4NN6K@976|Bacteroidetes 976|Bacteroidetes S Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - - - ko:K14160 - - - - ko00000,ko03400 - - - - k59_343243_1 717774.Marme_1463 2.03e-80 262.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1XIQV@135619|Oceanospirillales 135619|Oceanospirillales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_146967_2 572477.Alvin_1471 3.55e-18 87.0 COG0666@1|root,COG0666@2|Bacteria,1RFV0@1224|Proteobacteria,1S50I@1236|Gammaproteobacteria,1WYBK@135613|Chromatiales 135613|Chromatiales S PFAM Ankyrin - - - ko:K06867 - - - - ko00000 - - - Ank_2,Ank_4,Ank_5 k59_308384_1 349124.Hhal_2199 1.08e-20 86.7 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales 135613|Chromatiales E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_308384_2 1123257.AUFV01000001_gene1516 2.65e-63 198.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1X6D3@135614|Xanthomonadales 135614|Xanthomonadales O Peroxiredoxin bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_308384_3 396588.Tgr7_0824 3.93e-12 65.5 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales 135613|Chromatiales T SMART Nucleotide binding protein, PINc - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_766543_1 498211.CJA_0938 2.47e-46 162.0 COG1835@1|root,COG1835@2|Bacteria,1RJ7V@1224|Proteobacteria,1SC0Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_9748_1 1408224.SAMCCGM7_c5985 1.47e-11 65.5 COG4319@1|root,COG4319@2|Bacteria,1NCYK@1224|Proteobacteria,2UZTR@28211|Alphaproteobacteria,4BJYC@82115|Rhizobiaceae 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - - k59_669716_1 768671.ThimaDRAFT_0859 2.14e-51 183.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1WWMT@135613|Chromatiales 135613|Chromatiales P PFAM Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_732992_1 658187.LDG_7495 2.42e-66 216.0 COG5433@1|root,COG5433@2|Bacteria,1N9ZA@1224|Proteobacteria,1SJ16@1236|Gammaproteobacteria,1JFE8@118969|Legionellales 118969|Legionellales L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_996083_1 1121405.dsmv_2665 1.99e-87 286.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,42MZC@68525|delta/epsilon subdivisions,2WKRK@28221|Deltaproteobacteria,2MIYS@213118|Desulfobacterales 28221|Deltaproteobacteria C Protein of unknown function (DUF3683) - - - - - - - - - - - - CCG,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_10,Fer4_8 k59_962817_1 113395.AXAI01000011_gene6478 6.64e-68 218.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,3JS3D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Aminotransferase class-III rocD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_732994_1 1168034.FH5T_04685 8.56e-75 250.0 COG5000@1|root,COG5000@2|Bacteria,4NE49@976|Bacteroidetes,2FRVJ@200643|Bacteroidia 976|Bacteroidetes T COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation zraS_1 - - - - - - - - - - - HATPase_c,HisKA k59_670400_2 1122603.ATVI01000005_gene3870 1.95e-19 93.2 COG1196@1|root,COG1196@2|Bacteria,1R4SX@1224|Proteobacteria,1RVI9@1236|Gammaproteobacteria,1X8VV@135614|Xanthomonadales 135614|Xanthomonadales D Domain of Unknown Function (DUF349) - - - - - - - - - - - - DUF349 k59_996856_2 742817.HMPREF9449_00804 6.64e-16 70.5 2E359@1|root,32Y58@2|Bacteria,4NUXM@976|Bacteroidetes,2FUJX@200643|Bacteroidia,22YWY@171551|Porphyromonadaceae 976|Bacteroidetes S Domain of unknown function (DUF4295) - - - - - - - - - - - - DUF4295 k59_996856_3 1433126.BN938_0806 5e-34 117.0 COG0267@1|root,COG0267@2|Bacteria,4NURM@976|Bacteroidetes,2FTST@200643|Bacteroidia,22VHR@171550|Rikenellaceae 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL33 family rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_996856_4 1168034.FH5T_18505 6.36e-35 120.0 COG0227@1|root,COG0227@2|Bacteria,4NS7Q@976|Bacteroidetes,2FTTQ@200643|Bacteroidia 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL28 family rpmB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_275570_1 396588.Tgr7_0522 9.86e-93 282.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1WXFU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_275570_2 1123367.C666_01660 9.42e-11 63.9 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria,2KV1D@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_309129_1 713587.THITH_16390 3.05e-42 156.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales 135613|Chromatiales M PFAM Lytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_80931_2 1382306.JNIM01000001_gene1623 3.41e-43 156.0 COG1194@1|root,COG1194@2|Bacteria,2G62P@200795|Chloroflexi 200795|Chloroflexi L HhH-GPD family mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_80931_4 1347392.CCEZ01000018_gene1149 1.13e-45 158.0 COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,36DBQ@31979|Clostridiaceae 186801|Clostridia L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_180274_1 1168034.FH5T_06665 2.6e-58 182.0 COG1145@1|root,COG1145@2|Bacteria,4NSV2@976|Bacteroidetes,2FUDP@200643|Bacteroidia 976|Bacteroidetes C NIL - - - - - - - - - - - - Fer4,NIL k59_180274_2 860228.Ccan_23420 3.48e-07 52.0 COG1672@1|root,COG1672@2|Bacteria,4NGM3@976|Bacteroidetes,1I7BN@117743|Flavobacteriia 976|Bacteroidetes S ATPase (AAA superfamily) - - - - - - - - - - - - ATPase_2 k59_244326_1 709032.Sulku_0427 6.1e-35 127.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,42PJB@68525|delta/epsilon subdivisions,2YNGQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_244326_3 563040.Saut_0682 2.53e-22 93.6 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2YP1P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_439906_1 66897.DJ64_25775 1.02e-63 202.0 COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria 201174|Actinobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_733741_1 700598.Niako_3596 6.16e-51 177.0 COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,1IP0U@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_147778_1 563040.Saut_2035 8.38e-93 280.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2YN5V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L a g-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_539798_1 1120999.JONM01000023_gene3200 1.55e-42 149.0 COG2095@1|root,COG2095@2|Bacteria,1MV1C@1224|Proteobacteria,2VKRW@28216|Betaproteobacteria,2KR9I@206351|Neisseriales 206351|Neisseriales U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_80940_1 1313304.CALK_0394 2.51e-60 209.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria 2|Bacteria I 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_702227_1 469616.FMAG_01725 3.91e-138 401.0 COG0436@1|root,COG0436@2|Bacteria,3797Z@32066|Fusobacteria 32066|Fusobacteria E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_733750_1 588596.U9UUY5 7.6e-05 49.3 COG0790@1|root,KOG1550@2759|Eukaryota 588596.U9UUY5|- T ERAD pathway - - - - - - - - - - - - - k59_180280_1 933262.AXAM01000009_gene1475 1.4e-05 46.2 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42P90@68525|delta/epsilon subdivisions,2WK8R@28221|Deltaproteobacteria,2MI3H@213118|Desulfobacterales 28221|Deltaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_571705_1 1168034.FH5T_15170 1.14e-99 303.0 COG4775@1|root,COG4775@2|Bacteria,4NMIQ@976|Bacteroidetes,2FS3R@200643|Bacteroidia 976|Bacteroidetes M Surface antigen - - - - - - - - - - - - Bac_surface_Ag k59_275595_1 765912.Thimo_3151 1.76e-131 395.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWQV@135613|Chromatiales 135613|Chromatiales L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1028463_1 1045855.DSC_10045 7.5e-78 248.0 COG0732@1|root,COG0732@2|Bacteria,1Q4FB@1224|Proteobacteria,1RS7D@1236|Gammaproteobacteria,1X761@135614|Xanthomonadales 135614|Xanthomonadales L Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_637384_1 1408473.JHXO01000012_gene382 5.1e-144 419.0 COG2160@1|root,COG2160@2|Bacteria,4NHGG@976|Bacteroidetes,2FMIU@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the conversion of L-arabinose to L-ribulose araA - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Iso_C,Arabinose_Isome k59_767489_1 5762.XP_002676115.1 1.24e-28 119.0 COG0019@1|root,COG0527@1|root,KOG0456@2759|Eukaryota,KOG0622@2759|Eukaryota 2759|Eukaryota E putrescine biosynthetic process from ornithine - - 2.7.2.4,3.6.4.13,4.1.1.20,4.1.1.50 ko:K00928,ko:K01586,ko:K01611,ko:K18408 ko00260,ko00261,ko00270,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00034,M00133,M00525,M00526,M00527 R00178,R00451,R00480 RC00002,RC00043,RC00299 ko00000,ko00001,ko00002,ko01000,ko03036 - - iG2583_1286.G2583_3495 AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_309141_1 383407.XOC_3882 3.07e-59 187.0 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,1S3T6@1236|Gammaproteobacteria,1X6I0@135614|Xanthomonadales 135614|Xanthomonadales H synthase ptpS - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_840010_2 385682.AFSL01000008_gene2566 3.9e-30 121.0 COG0358@1|root,COG0358@2|Bacteria,4NENT@976|Bacteroidetes,2FMV1@200643|Bacteroidia,3XJ52@558415|Marinilabiliaceae 976|Bacteroidetes L zinc finger dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_644532_1 395961.Cyan7425_1105 7.62e-93 280.0 COG1089@1|root,COG1089@2|Bacteria,1G2FW@1117|Cyanobacteria,3KGXG@43988|Cyanothece 1117|Cyanobacteria H Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose yefA - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_88320_1 1112212.JH584235_gene3033 1.38e-05 45.8 COG0824@1|root,COG0824@2|Bacteria,1NBU7@1224|Proteobacteria,2UF7N@28211|Alphaproteobacteria,2K5KH@204457|Sphingomonadales 204457|Sphingomonadales S Thioesterase superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_88320_2 344747.PM8797T_05550 2.97e-116 348.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,2IZS3@203682|Planctomycetes 203682|Planctomycetes L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18 k59_219836_2 391625.PPSIR1_28606 1.47e-61 202.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2YUMG@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_446980_1 394221.Mmar10_0178 1.16e-134 413.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,43WSR@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1004081_1 1255043.TVNIR_2062 1.62e-86 270.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXFK@135613|Chromatiales 135613|Chromatiales GM nucleoside-diphosphate sugar epimerase - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_121277_1 187272.Mlg_0413 2.57e-83 261.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_840021_1 1283300.ATXB01000001_gene1705 2.4e-38 143.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1SZW9@1236|Gammaproteobacteria,1XFPE@135618|Methylococcales 135618|Methylococcales L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_840021_2 387092.NIS_1306 1.29e-38 136.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,42RV4@68525|delta/epsilon subdivisions,2YP42@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_155503_1 244582.JQAK01000042_gene2323 6.75e-10 59.7 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,47EZV@766|Rickettsiales 766|Rickettsiales C Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3,1.6.99.3 ko:K00331,ko:K03940 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 - - Oxidored_q6 k59_155503_2 1049564.TevJSym_ap00620 1.44e-47 155.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,1J799@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_447688_1 1123312.KB904562_gene1825 1.29e-90 293.0 COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,4HA45@91061|Bacilli 91061|Bacilli G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_351729_1 349521.HCH_06516 1.62e-40 153.0 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria,1XK5Q@135619|Oceanospirillales 135619|Oceanospirillales M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag k59_804613_1 768706.Desor_0063 1.11e-25 108.0 COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,25C37@186801|Clostridia,261JY@186807|Peptococcaceae 186801|Clostridia M peptidyl-prolyl isomerase - - 5.2.1.8 ko:K03769,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Cu_amine_oxidN1,Rotamase_2,Rotamase_3,SurA_N_3 k59_283399_1 216594.MMAR_2578 4.93e-53 189.0 COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,232MQ@1762|Mycobacteriaceae 201174|Actinobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.6 ko:K01535 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.3 - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1035879_1 411477.PARMER_04001 1.09e-21 91.7 COG1212@1|root,COG1212@2|Bacteria,4NG4B@976|Bacteroidetes,2FMHD@200643|Bacteroidia,22XG8@171551|Porphyromonadaceae 976|Bacteroidetes M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_1035879_2 641526.ADIWIN_2163 9.57e-06 50.8 2DBYK@1|root,2ZBVZ@2|Bacteria,4NMDE@976|Bacteroidetes,1I1KM@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1035879_3 1168289.AJKI01000015_gene2161 2.41e-87 283.0 COG1026@1|root,COG1026@2|Bacteria,4PJ9W@976|Bacteroidetes,2G279@200643|Bacteroidia,3XKNA@558415|Marinilabiliaceae 976|Bacteroidetes S Peptidase M16C associated - - - - - - - - - - - - M16C_assoc,Peptidase_M16_C k59_775294_1 97139.C824_05071 9.31e-60 203.0 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,36DTS@31979|Clostridiaceae 186801|Clostridia K Belongs to the ParB family spo0J - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_678486_1 1219375.CM002139_gene70 7.22e-69 236.0 COG0591@1|root,COG0642@1|root,COG0745@1|root,COG0591@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_283403_2 941449.dsx2_3369 6.87e-94 278.0 COG0346@1|root,COG0346@2|Bacteria,1PM7Y@1224|Proteobacteria,42RD3@68525|delta/epsilon subdivisions,2WNY7@28221|Deltaproteobacteria,2M92N@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_415332_1 338963.Pcar_2425 1.11e-96 296.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_447723_1 105559.Nwat_0935 4.91e-88 288.0 COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales 135613|Chromatiales DM mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM,MscS_porin k59_122024_1 272134.KB731324_gene3889 1.52e-35 135.0 2DBFF@1|root,2Z8YA@2|Bacteria,1G2KB@1117|Cyanobacteria,1HE5F@1150|Oscillatoriales 1117|Cyanobacteria L Helix-turn-helix of DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_4,HTH_Tnp_4 k59_316833_1 713586.KB900536_gene2548 2.22e-30 123.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales 135613|Chromatiales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_579363_2 1415780.JPOG01000001_gene3234 1.56e-74 234.0 COG1028@1|root,COG1028@2|Bacteria,1RAEZ@1224|Proteobacteria,1S615@1236|Gammaproteobacteria,1X6DB@135614|Xanthomonadales 135614|Xanthomonadales IQ KR domain - - - - - - - - - - - - adh_short k59_547272_1 479434.Sthe_2697 4.76e-41 146.0 COG1656@1|root,COG1977@1|root,COG1656@2|Bacteria,COG1977@2|Bacteria,2G6GZ@200795|Chloroflexi,27Y8I@189775|Thermomicrobia 189775|Thermomicrobia H Mut7-C ubiquitin - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_480699_2 529818.AMSG_12443T0 6.54e-08 58.9 COG2217@1|root,KOG0207@2759|Eukaryota 2759|Eukaryota P cation-transporting ATPase activity - - - - - - - - - - - - E1-E2_ATPase,Hydrolase k59_872868_1 795666.MW7_3528 3.08e-50 179.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,1JZWN@119060|Burkholderiaceae 28216|Betaproteobacteria M D-alanyl-d-alanine carboxypeptidase dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_775322_2 519989.ECTPHS_06482 2.62e-28 118.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales 135613|Chromatiales U type IV pilus secretin PilQ - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_283424_2 426114.THI_1141 1.38e-51 169.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2VJR4@28216|Betaproteobacteria,1KKYT@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Hemolysin III - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_678508_1 572544.Ilyop_1526 1.65e-128 382.0 COG0025@1|root,COG1762@1|root,COG0025@2|Bacteria,COG1762@2|Bacteria,37CPG@32066|Fusobacteria 32066|Fusobacteria GPT Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger,PTS_EIIA_2 k59_515593_1 868131.MSWAN_0303 9.44e-62 206.0 COG1232@1|root,arCOG01522@2157|Archaea,2XY37@28890|Euryarchaeota 28890|Euryarchaeota H PFAM amine oxidase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_515593_2 404380.Gbem_2934 1.82e-32 125.0 COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,42QDK@68525|delta/epsilon subdivisions 1224|Proteobacteria H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_283436_1 1137281.D778_01912 1.01e-62 201.0 COG0535@1|root,COG0535@2|Bacteria,4NGWY@976|Bacteroidetes,1I14P@117743|Flavobacteriia 976|Bacteroidetes C radical SAM domain protein - - - - - - - - - - - - Fer4_14,Radical_SAM,SPASM k59_775331_1 1500897.JQNA01000002_gene697 3.7e-92 283.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria,1K5SV@119060|Burkholderiaceae 28216|Betaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_23,rve k59_188066_1 1249627.D779_1887 3.67e-97 290.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1WX0N@135613|Chromatiales 135613|Chromatiales I Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_188066_2 983545.Glaag_3151 1.44e-15 73.9 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,466FX@72275|Alteromonadaceae 1236|Gammaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_252352_1 378806.STAUR_5205 2.6e-105 325.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria,2YXXC@29|Myxococcales 28221|Deltaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_612789_1 869213.JCM21142_1590 8.13e-53 183.0 COG0613@1|root,COG0613@2|Bacteria,4NGUQ@976|Bacteroidetes 976|Bacteroidetes S PHP domain protein - - - - - - - - - - - - PHP k59_840652_1 1168034.FH5T_21935 1.19e-109 342.0 COG4775@1|root,COG4775@2|Bacteria,4NE6Z@976|Bacteroidetes,2FM76@200643|Bacteroidia 976|Bacteroidetes M Outer membrane protein assembly complex, YaeT protein yaeT - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_54338_1 338963.Pcar_2557 5.17e-70 233.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,43UHA@69541|Desulfuromonadales 28221|Deltaproteobacteria M Bifunctional transglycosylase second domain mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_351784_1 631454.N177_2489 8.81e-65 209.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,1JN05@119043|Rhodobiaceae 28211|Alphaproteobacteria I Thiolase, N-terminal domain phbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_872881_1 697282.Mettu_2567 1.53e-41 146.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1XE0T@135618|Methylococcales 135618|Methylococcales S Peptidase family M50 - - - - - - - - - - - - - k59_872881_4 12336.Q332C0_CBCP 2.6e-29 119.0 4QBT2@10239|Viruses 10239|Viruses - - - - - - - - - - - - - - - k59_188077_1 572544.Ilyop_1087 1.78e-71 229.0 COG1220@1|root,COG1220@2|Bacteria,379DK@32066|Fusobacteria 32066|Fusobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_283451_1 396588.Tgr7_3303 3.71e-64 211.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1WWG8@135613|Chromatiales 135613|Chromatiales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_1004748_2 536019.Mesop_5710 2.84e-45 157.0 COG4948@1|root,COG4948@2|Bacteria,1NI9F@1224|Proteobacteria,2TVSH@28211|Alphaproteobacteria,43NM3@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M mandelate racemase muconate lactonizing - - 4.2.1.40 ko:K01706 ko00053,ko01100,map00053,map01100 - R02752,R08056 RC00543 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_415378_1 1121396.KB892935_gene3808 8.28e-88 267.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WIYY@28221|Deltaproteobacteria,2MHTK@213118|Desulfobacterales 28221|Deltaproteobacteria S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_547304_1 886379.AEWI01000007_gene814 1.58e-61 205.0 COG0187@1|root,COG0187@2|Bacteria,4NF18@976|Bacteroidetes,2FMMD@200643|Bacteroidia,3XJF2@558415|Marinilabiliaceae 976|Bacteroidetes L TopoisomeraseII parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_122063_1 566466.NOR53_2107 1.42e-86 269.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4I6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_645375_1 1122194.AUHU01000004_gene1601 2.18e-51 183.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,464XP@72275|Alteromonadaceae 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_447784_1 572544.Ilyop_1118 3.64e-40 149.0 COG2239@1|root,COG2239@2|Bacteria,378KN@32066|Fusobacteria 32066|Fusobacteria P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_188091_1 1168034.FH5T_09335 2.73e-45 164.0 COG4704@1|root,COG4704@2|Bacteria,4NGPF@976|Bacteroidetes,2FNAC@200643|Bacteroidia 976|Bacteroidetes S Bacterial Ig-like domain - - - - - - - - - - - - Big_5,fn3_3 k59_678547_1 1168034.FH5T_12455 3.82e-94 284.0 COG5504@1|root,COG5504@2|Bacteria,4NFZP@976|Bacteroidetes,2FMM9@200643|Bacteroidia 976|Bacteroidetes O Psort location Cytoplasmic, score 8.96 gldB - - - - - - - - - - - - k59_840672_1 1229205.BUPH_08508 1.72e-115 337.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_547314_1 745411.B3C1_07439 4.04e-19 89.0 2DBI4@1|root,2Z9EH@2|Bacteria,1MXNH@1224|Proteobacteria,1RT1Y@1236|Gammaproteobacteria,1J6JT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_547314_2 251229.Chro_2778 3.02e-118 351.0 COG0161@1|root,COG0161@2|Bacteria,1G1QE@1117|Cyanobacteria,3VJI9@52604|Pleurocapsales 1117|Cyanobacteria H Aminotransferase class-III bioA - 2.6.1.18,2.6.1.62 ko:K00822,ko:K00833 ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100 M00123,M00573,M00577 R00907,R03231,R04187 RC00006,RC00008,RC00062,RC00160,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_741514_1 1226994.AMZB01000123_gene2933 8.87e-41 171.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1YCTA@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria NU COG3170 Tfp pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - LysM,TPR_19 k59_741514_2 768671.ThimaDRAFT_3671 1.97e-106 318.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1WX2M@135613|Chromatiales 135613|Chromatiales J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_741514_4 629265.PMA4326_29040 1.21e-81 248.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1Z792@136849|Pseudomonas syringae group 1236|Gammaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_741514_5 2340.JV46_26460 5.16e-248 686.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1J5D5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_741514_6 472759.Nhal_1970 4.34e-115 338.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales 135613|Chromatiales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_316883_1 2340.JV46_13030 1.39e-78 242.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_415408_1 326298.Suden_1371 1.06e-80 253.0 COG0477@1|root,COG2814@2|Bacteria,1QRUM@1224|Proteobacteria,42MFJ@68525|delta/epsilon subdivisions,2YMW9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_283472_1 1304883.KI912532_gene578 3.6e-16 77.4 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,2KWD2@206389|Rhodocyclales 206389|Rhodocyclales NU fimbrial biogenesis protein PilN pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_283472_2 204773.HEAR3123 1.27e-22 94.4 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,473PW@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_220594_1 765912.Thimo_2538 1.91e-91 281.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_612835_2 713587.THITH_09080 6.6e-40 137.0 COG2259@1|root,COG2259@2|Bacteria,1MZC7@1224|Proteobacteria,1SANJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DoxX family - - - ko:K15977 - - - - ko00000 - - - DoxX k59_1044155_1 391615.ABSJ01000002_gene484 1.78e-07 55.5 COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SGPC@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Anti sigma-E protein RseA mucA - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_C,RseA_N k59_1044155_2 1049564.TevJSym_ah00320 1.32e-14 73.9 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1J65J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T MucB/RseB C-terminal domain rseB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045152 - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_717576_1 405948.SACE_3490 3.23e-30 124.0 COG0784@1|root,COG1511@1|root,COG5002@1|root,COG0784@2|Bacteria,COG1511@2|Bacteria,COG5002@2|Bacteria,2GKQX@201174|Actinobacteria,4E13B@85010|Pseudonocardiales 201174|Actinobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,Response_reg k59_196062_1 1348635.BBJY01000001_gene2357 3.3e-91 287.0 COG2213@1|root,COG4668@1|root,COG2213@2|Bacteria,COG4668@2|Bacteria,1MUPU@1224|Proteobacteria,1RNAG@1236|Gammaproteobacteria,1XSK5@135623|Vibrionales 135623|Vibrionales G PTS system mannitol-specific transporter subunit IICBA mtlA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015166,GO:0015318,GO:0015575,GO:0015791,GO:0015797,GO:0015850,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:1901618 2.7.1.197 ko:K02798,ko:K02799,ko:K02800 ko00051,ko02060,map00051,map02060 M00274 R02704 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB k59_913351_1 717231.Flexsi_0805 1.57e-82 252.0 COG1091@1|root,COG1091@2|Bacteria,2GFM9@200930|Deferribacteres 200930|Deferribacteres C Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_487511_1 1033810.HLPCO_001172 6.31e-15 78.6 COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria 2|Bacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030428,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_196065_1 1168034.FH5T_11955 2.66e-90 265.0 COG0652@1|root,COG0652@2|Bacteria,4NKQ7@976|Bacteroidetes,2FSSH@200643|Bacteroidia 976|Bacteroidetes O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_392071_2 929506.CbC4_2070 2.52e-18 84.0 COG0635@1|root,COG0635@2|Bacteria,1TUUY@1239|Firmicutes,2490N@186801|Clostridia,36GCR@31979|Clostridiaceae 186801|Clostridia H coproporphyrinogen III oxidase - - - - - - - - - - - - Radical_SAM k59_290960_2 1249480.B649_10225 2.37e-20 82.8 2A4UE@1|root,30TFZ@2|Bacteria,1PDA5@1224|Proteobacteria,42WVN@68525|delta/epsilon subdivisions,2YQRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_129690_2 580332.Slit_0659 2.75e-17 84.0 COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2VUA6@28216|Betaproteobacteria,44WFX@713636|Nitrosomonadales 28216|Betaproteobacteria L Staphylococcal nuclease homologues - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase k59_359055_1 1408428.JNJP01000055_gene140 1.72e-42 149.0 COG2602@1|root,COG2602@2|Bacteria,1NWXE@1224|Proteobacteria,42QWH@68525|delta/epsilon subdivisions,2WR66@28221|Deltaproteobacteria,2MBP5@213115|Desulfovibrionales 28221|Deltaproteobacteria M Penicillin binding protein transpeptidase domain - - 3.5.2.6 ko:K17838 ko01501,map01501 - R06363 RC01499 ko00000,ko00001,ko01000 - - - Transpeptidase k59_359055_2 990073.ATHU01000002_gene64 0.000213 42.7 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2YP8T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D nucleotide-binding protein implicated in inhibition of septum formation maf - - ko:K06287 - - - - ko00000 - - - Maf k59_748516_1 1168034.FH5T_08385 1.31e-135 409.0 COG3292@1|root,COG3292@2|Bacteria,4NDWE@976|Bacteroidetes,2FQ6Y@200643|Bacteroidia 976|Bacteroidetes T Two component regulator propeller - - - - - - - - - - - - Reg_prop k59_652502_2 1537915.JU57_04950 2.55e-59 197.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2YN35@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Nucleotidyltransferase DNA polymerase involved in DNA repair dinP - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_96433_1 760154.Sulba_1000 7.08e-65 207.0 COG3943@1|root,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,42NYC@68525|delta/epsilon subdivisions,2YN8N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Virulence protein RhuM family - - - - - - - - - - - - Virulence_RhuM k59_259853_1 710686.Mycsm_04306 2.28e-46 170.0 COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria,232HX@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the GPAT DAPAT family plsB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_26145_1 522373.Smlt0801 1.04e-24 100.0 COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria,1X3BY@135614|Xanthomonadales 135614|Xanthomonadales K Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_26145_2 2340.JV46_10100 2.76e-60 188.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1JA7F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF971) - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - DUF971 k59_259854_1 2340.JV46_24730 5.83e-62 207.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1J5N2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state bepA GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_M48,TPR_19 k59_947088_1 1304885.AUEY01000033_gene1899 1.59e-51 177.0 COG3203@1|root,COG3203@2|Bacteria,1PJNW@1224|Proteobacteria,42TCM@68525|delta/epsilon subdivisions,2WPPQ@28221|Deltaproteobacteria,2MNBT@213118|Desulfobacterales 28221|Deltaproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_422582_1 572544.Ilyop_1516 5.59e-91 282.0 COG0696@1|root,COG0696@2|Bacteria,378G0@32066|Fusobacteria 32066|Fusobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_717600_1 555778.Hneap_1375 3.5e-89 271.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1WXPM@135613|Chromatiales 135613|Chromatiales S PFAM Alcohol dehydrogenase - - - ko:K12957,ko:K13979 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_880384_1 760154.Sulba_1574 3e-76 241.0 COG0270@1|root,COG0270@2|Bacteria,1R59Y@1224|Proteobacteria,42Z5R@68525|delta/epsilon subdivisions,2YRE6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_686251_1 1537917.JU82_03910 1.43e-68 221.0 COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,42NH5@68525|delta/epsilon subdivisions,2YMK5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member - - - - - - - - - - - - Herpes_Helicase,PIF1 k59_717605_1 1304885.AUEY01000015_gene2996 5.88e-73 236.0 COG1219@1|root,COG1219@2|Bacteria,1MWIZ@1224|Proteobacteria,42N1Z@68525|delta/epsilon subdivisions,2WJUS@28221|Deltaproteobacteria,2MHMD@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the ClpX chaperone family - - - - - - - - - - - - AAA_2,ClpB_D2-small k59_620461_1 1304284.L21TH_0966 1.69e-139 411.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,36DS1@31979|Clostridiaceae 186801|Clostridia EG Belongs to the IlvD Edd family ilvD3 - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_587486_1 1355368.JART01000013_gene393 1.11e-36 138.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2YM83@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_587486_2 1123058.KB894236_gene749 3.18e-167 487.0 COG1475@1|root,COG1475@2|Bacteria,4NJ58@976|Bacteroidetes 976|Bacteroidetes K DNA binding - - - - - - - - - - - - - k59_587486_3 1123058.KB894236_gene750 3.13e-162 460.0 COG0338@1|root,COG0338@2|Bacteria,4NIEI@976|Bacteroidetes,1I07R@117743|Flavobacteriia 976|Bacteroidetes L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_587486_4 1120980.JQKH01000044_gene1334 4.65e-24 99.4 COG3738@1|root,COG3738@2|Bacteria,1RE1M@1224|Proteobacteria,2VQ0T@28216|Betaproteobacteria,2KR1N@206351|Neisseriales 206351|Neisseriales S Domain of unknown function (DUF1287) - - - - - - - - - - - - DUF1287 k59_1011886_2 666685.R2APBS1_2361 2.7e-91 273.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RR3R@1236|Gammaproteobacteria,1X57K@135614|Xanthomonadales 135614|Xanthomonadales V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_847775_1 338969.Rfer_2524 7.63e-26 105.0 COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,2VQ1F@28216|Betaproteobacteria,4AE3D@80864|Comamonadaceae 28216|Betaproteobacteria S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16,TPR_17 k59_847775_2 1385515.N791_03520 1.34e-11 62.0 2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria,1X82S@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_620464_1 1168034.FH5T_14030 3.02e-127 366.0 COG0363@1|root,COG0363@2|Bacteria,4NGB9@976|Bacteroidetes,2FNZF@200643|Bacteroidia 976|Bacteroidetes G 6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_620464_2 1168289.AJKI01000006_gene238 4.09e-45 159.0 COG0364@1|root,COG0364@2|Bacteria,4NE59@976|Bacteroidetes,2FNER@200643|Bacteroidia,3XIQC@558415|Marinilabiliaceae 976|Bacteroidetes G Glucose-6-phosphate dehydrogenase, NAD binding domain zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_456971_1 667015.Bacsa_2240 2.45e-71 236.0 COG3291@1|root,COG3291@2|Bacteria,4PKU5@976|Bacteroidetes,2G0D2@200643|Bacteroidia,4AV7Q@815|Bacteroidaceae 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - - k59_1011887_1 400668.Mmwyl1_3123 7.21e-102 318.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1S02D@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Dehydrogenase E1 component - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_748548_2 111781.Lepto7376_2178 1.39e-22 105.0 COG4995@1|root,COG4995@2|Bacteria,1GQRN@1117|Cyanobacteria,1HHZ5@1150|Oscillatoriales 1117|Cyanobacteria S CHAT domain - - - - - - - - - - - - CHAT k59_652529_1 338966.Ppro_2746 2.11e-89 281.0 COG0558@1|root,COG0558@2|Bacteria,1MYE7@1224|Proteobacteria,43F1I@68525|delta/epsilon subdivisions,2WXQ5@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - - - - - - - - - - CDP-OH_P_transf k59_1044199_1 1283300.ATXB01000001_gene665 3.58e-74 238.0 COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1XG73@135618|Methylococcales 135618|Methylococcales G Starch synthase catalytic domain - GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_1044199_2 765912.Thimo_2911 2.12e-153 444.0 COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_359097_1 1121028.ARQE01000001_gene3520 9.64e-35 126.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,2PJDC@255475|Aurantimonadaceae 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_359097_2 288000.BBta_0408 9.81e-31 120.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,3JTVC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_292151_2 1286106.MPL1_00922 5.76e-25 103.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,45ZN3@72273|Thiotrichales 72273|Thiotrichales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_97505_1 384765.SIAM614_05391 4e-10 65.9 COG3904@1|root,COG3904@2|Bacteria,1NHQR@1224|Proteobacteria 1224|Proteobacteria T sh3 domain protein - - - - - - - - - - - - SH3_3 k59_130541_1 933262.AXAM01000027_gene2112 4.47e-07 57.0 COG2885@1|root,COG3267@1|root,COG2885@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42PJ3@68525|delta/epsilon subdivisions,2WJF6@28221|Deltaproteobacteria,2MJ4S@213118|Desulfobacterales 28221|Deltaproteobacteria MU AAA domain - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,OmpA k59_26969_1 632335.Calkr_2309 6.29e-08 57.4 COG1309@1|root,COG1309@2|Bacteria,1VDN9@1239|Firmicutes,25MJX@186801|Clostridia,42H8F@68295|Thermoanaerobacterales 186801|Clostridia K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N k59_130547_1 1121875.KB907553_gene20 9.35e-73 232.0 COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_130551_1 399739.Pmen_0912 1.9e-75 235.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1YDF2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_97513_1 1168034.FH5T_17985 5.55e-12 72.8 COG2207@1|root,COG3063@1|root,COG5616@1|root,COG2207@2|Bacteria,COG3063@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - HTH_18,TPR_8 k59_881226_1 1049564.TevJSym_ag00070 5.77e-48 160.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1J7JW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Cytochrome C1 family petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_881226_2 472759.Nhal_3861 6.24e-56 186.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1WWQP@135613|Chromatiales 135613|Chromatiales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_783912_1 1123368.AUIS01000005_gene487 5.56e-109 335.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RYC8@1236|Gammaproteobacteria,2NC3Q@225057|Acidithiobacillales 225057|Acidithiobacillales G D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase - - - - - - - - - - - - XFP,XFP_N k59_947899_1 706587.Desti_4204 7.99e-142 411.0 COG0467@1|root,COG1476@1|root,COG1917@1|root,COG0467@2|Bacteria,COG1476@2|Bacteria,COG1917@2|Bacteria,1PE60@1224|Proteobacteria,42NFD@68525|delta/epsilon subdivisions,2WK1C@28221|Deltaproteobacteria,2MQST@213462|Syntrophobacterales 28221|Deltaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - Cupin_2,HTH_3 k59_848636_1 339670.Bamb_4899 8.42e-23 93.2 COG4922@1|root,COG4922@2|Bacteria,1RDM5@1224|Proteobacteria,2VSBK@28216|Betaproteobacteria,1KAG5@119060|Burkholderiaceae 28216|Betaproteobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL,SnoaL_2 k59_97527_1 1205908.AKXW01000127_gene425 6.73e-85 266.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1XVPF@135623|Vibrionales 135623|Vibrionales L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_26989_1 926560.KE387027_gene540 5.69e-43 158.0 COG2939@1|root,COG2939@2|Bacteria,1WJMU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_62947_1 1037409.BJ6T_52870 1.18e-95 295.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,3JSJ1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - DUF4994,Sulfatase,Sulfatase_C k59_260932_1 1168034.FH5T_15265 6.07e-79 261.0 COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,2FM0P@200643|Bacteroidia 976|Bacteroidetes G beta-galactosidase - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_292173_1 572544.Ilyop_1354 1.47e-295 830.0 COG2217@1|root,COG2217@2|Bacteria,378U0@32066|Fusobacteria 32066|Fusobacteria P Psort location CytoplasmicMembrane, score 10.00 cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase k59_881246_1 266264.Rmet_1492 2.02e-09 62.8 COG0191@1|root,COG0191@2|Bacteria,1R6TC@1224|Proteobacteria,2VMUH@28216|Betaproteobacteria 28216|Betaproteobacteria G ketose-bisphosphate aldolase - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_1044993_3 234267.Acid_7639 2.62e-98 301.0 COG3344@1|root,COG3344@2|Bacteria,3Y46K@57723|Acidobacteria 57723|Acidobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1,RVT_N k59_26997_1 247633.GP2143_10202 1.96e-24 103.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria,1J600@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent phosphoesterases (PHP family) trpH GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_62954_2 1211819.CALK01000023_gene1676 1.28e-06 50.1 COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,3VTXI@526524|Erysipelotrichia 526524|Erysipelotrichia M Monogalactosyldiacylglycerol (MGDG) synthase - - - - - - - - - - - - Glyco_tran_28_C,MGDG_synth k59_947916_1 879212.DespoDRAFT_02816 5.11e-44 167.0 COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria,2MI3Z@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family qrcB - - ko:K08357 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_914371_1 596315.HMPREF0634_1518 2.13e-36 149.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,25QY6@186804|Peptostreptococcaceae 186801|Clostridia J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_914371_2 1121468.AUBR01000096_gene774 6.13e-16 82.4 COG0237@1|root,COG2131@1|root,COG0237@2|Bacteria,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,42GBV@68295|Thermoanaerobacterales 186801|Clostridia F PFAM CMP dCMP deaminase zinc-binding comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_914371_3 926551.KB900735_gene1489 6.01e-32 116.0 COG4696@1|root,COG4696@2|Bacteria,4NNW2@976|Bacteroidetes,1I23U@117743|Flavobacteriia,1ET44@1016|Capnocytophaga 976|Bacteroidetes S Phosphoribosyl-ATP pyrophosphohydrolase - - - - - - - - - - - - PRA-PH k59_914371_4 1348662.CARG_01140 2.06e-08 53.1 COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,22MWG@1653|Corynebacteriaceae 201174|Actinobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_979943_2 523791.Kkor_1776 6.37e-11 64.7 COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,1RXX1@1236|Gammaproteobacteria,1XQQE@135619|Oceanospirillales 135619|Oceanospirillales E Zn_pept - - - - - - - - - - - - Peptidase_M14,Peptidase_M6 k59_130621_1 1121440.AUMA01000005_gene2638 1.09e-108 337.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,42MQD@68525|delta/epsilon subdivisions,2WJJP@28221|Deltaproteobacteria,2M9EB@213115|Desulfovibrionales 28221|Deltaproteobacteria P transporter antisigma-factor antagonist STAS - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_97565_1 1168034.FH5T_17190 4.57e-66 207.0 COG0330@1|root,COG0330@2|Bacteria,4NFNB@976|Bacteroidetes 976|Bacteroidetes O COG0330 Membrane protease subunits stomatin prohibitin homologs - - - - - - - - - - - - Band_7 k59_718751_1 563040.Saut_1238 8.15e-22 88.6 COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,42RIS@68525|delta/epsilon subdivisions,2YQBI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C k59_689515_1 563040.Saut_0923 7.63e-112 327.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2YN2X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_689515_2 1537917.JU82_07225 1.68e-156 442.0 COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,42KZK@68525|delta/epsilon subdivisions,2YMUM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ dehydrogenase hdhA - 1.1.1.159 ko:K00076 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - adh_short_C2 k59_68195_1 86416.Clopa_4711 1.46e-86 267.0 COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia,36DFN@31979|Clostridiaceae 186801|Clostridia G glucuronate isomerase uxaC - 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - - UxaC k59_68195_2 553220.CAMGR0001_2818 2.2e-09 60.5 COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,42MRF@68525|delta/epsilon subdivisions,2YMPT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glycerate kinase type-1 family garK - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase k59_362481_1 1049564.TevJSym_az00370 8.13e-114 335.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1J596@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type Mn2 Zn2 transport systems, permease znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_362481_2 765912.Thimo_0041 6.63e-51 168.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,1WXP4@135613|Chromatiales 135613|Chromatiales P ABC transporter znuC - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_427678_1 1168034.FH5T_12620 4.12e-158 462.0 COG0021@1|root,COG0021@2|Bacteria,4P14U@976|Bacteroidetes,2FN0P@200643|Bacteroidia 976|Bacteroidetes G Belongs to the transketolase family tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_558971_1 1232437.KL661988_gene190 7.59e-83 257.0 COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria,42MHA@68525|delta/epsilon subdivisions,2WMF3@28221|Deltaproteobacteria,2MK9F@213118|Desulfobacterales 28221|Deltaproteobacteria P Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1 k59_330114_1 563040.Saut_1636 7.72e-68 214.0 COG4508@1|root,COG4508@2|Bacteria,1RAX1@1224|Proteobacteria,42MG5@68525|delta/epsilon subdivisions,2YN7I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM dUTPase dut - - - - - - - - - - - dUTPase_2 k59_297074_1 865937.Gilli_1223 1.17e-79 253.0 COG1834@1|root,COG1834@2|Bacteria,4PP4T@976|Bacteroidetes 976|Bacteroidetes E Pfam:SusD - - - - - - - - - - - - SusD-like_3,SusD_RagB k59_362486_1 1123355.JHYO01000010_gene3528 9.08e-70 223.0 COG2223@1|root,COG2223@2|Bacteria,1MW71@1224|Proteobacteria,2TWVJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_885220_1 572544.Ilyop_1170 1.07e-139 404.0 COG0452@1|root,COG0452@2|Bacteria,37970@32066|Fusobacteria 32066|Fusobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_722177_1 926556.Echvi_3397 1.12e-113 339.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,47MVU@768503|Cytophagia 976|Bacteroidetes G Pectate lyase - - - - - - - - - - - - Lipase_GDSL_2 k59_68211_1 485915.Dret_2378 1.92e-65 223.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MG2T@213115|Desulfovibrionales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_264217_1 332101.JIBU02000022_gene5098 2.74e-74 238.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,36DH5@31979|Clostridiaceae 186801|Clostridia F Guanine deaminase guaD - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_264217_2 572544.Ilyop_1515 9.81e-215 598.0 COG0012@1|root,COG0012@2|Bacteria,378UB@32066|Fusobacteria 32066|Fusobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_983488_1 398720.MED217_04562 6.75e-34 134.0 COG4206@1|root,COG4206@2|Bacteria,4NHTX@976|Bacteroidetes,1I7EP@117743|Flavobacteriia,2XJUR@283735|Leeuwenhoekiella 976|Bacteroidetes H TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_362503_1 983545.Glaag_4274 5.84e-19 86.7 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,46440@72275|Alteromonadaceae 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_362503_2 883126.HMPREF9710_02404 7.77e-29 119.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4760P@75682|Oxalobacteraceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 k59_624055_1 1137799.GZ78_19000 5.78e-41 153.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1XI65@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_754582_1 468059.AUHA01000003_gene1728 1.48e-36 131.0 COG1926@1|root,COG1926@2|Bacteria,4NNIW@976|Bacteroidetes,1IW0G@117747|Sphingobacteriia 976|Bacteroidetes S Phosphoribosyl transferase domain - - - ko:K07100 - - - - ko00000 - - - Pribosyltran k59_754582_2 56780.SYN_01247 9.19e-21 84.3 2DCXT@1|root,2ZFR8@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_395333_1 1120970.AUBZ01000008_gene2461 3.42e-44 146.0 COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,467E8@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0145 family ybjQ - - - - - - - - - - - YbjQ_1 k59_395333_2 1125973.JNLC01000016_gene2927 6.23e-08 50.8 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Cold shock - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_68221_1 1168034.FH5T_12535 4.35e-143 411.0 COG1181@1|root,COG1181@2|Bacteria,4NE9P@976|Bacteroidetes,2FNMC@200643|Bacteroidia 976|Bacteroidetes F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_657204_2 1379698.RBG1_1C00001G0979 5.4e-45 152.0 COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, ATPase component mkl - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_591341_1 519989.ECTPHS_01424 2.68e-20 98.2 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,Response_reg k59_820207_1 387093.SUN_1975 4.58e-112 328.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2YMMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_35324_1 323848.Nmul_A1399 3.97e-14 75.1 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria 28216|Betaproteobacteria S Phospholipase, patatin family - - - ko:K07001 - - - - ko00000 - - - Patatin k59_68223_1 1168034.FH5T_13125 1.49e-99 299.0 COG2199@1|root,COG4585@1|root,COG3706@2|Bacteria,COG4585@2|Bacteria,4NI9U@976|Bacteroidetes 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA_3,Reg_prop,Y_Y_Y k59_330144_1 700598.Niako_2564 6.45e-05 47.8 COG3034@1|root,COG3034@2|Bacteria,4NNK3@976|Bacteroidetes,1ISMP@117747|Sphingobacteriia 976|Bacteroidetes S ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD k59_330144_2 387093.SUN_0346 1.65e-38 142.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2YMJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_199059_1 1123371.ATXH01000017_gene640 2.72e-49 178.0 COG0178@1|root,COG0178@2|Bacteria,2GGUR@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_493453_1 519989.ECTPHS_01134 1.84e-76 253.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_330151_1 485918.Cpin_0233 2.03e-58 203.0 COG0770@1|root,COG0787@1|root,COG0770@2|Bacteria,COG0787@2|Bacteria,4NEXM@976|Bacteroidetes,1IP9R@117747|Sphingobacteriia 976|Bacteroidetes M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1,6.3.2.10 ko:K01775,ko:K01929 ko00300,ko00473,ko00550,ko01100,ko01502,map00300,map00473,map00550,map01100,map01502 - R00401,R04573,R04617 RC00064,RC00141,RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N,Mur_ligase,Mur_ligase_M k59_657220_1 1165841.SULAR_04417 3.57e-78 252.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2YMEF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M penicillin-binding protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_134056_1 944547.ABLL_2677 2.49e-90 280.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2YMK9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase k59_559013_1 1168034.FH5T_10385 7.89e-144 442.0 COG1277@1|root,COG1277@2|Bacteria,4NI5T@976|Bacteroidetes,2FNVZ@200643|Bacteroidia 976|Bacteroidetes E ABC-type transport system involved in multi-copper enzyme maturation permease component - - - - - - - - - - - - Peptidase_M1 k59_820214_1 765912.Thimo_2743 2.62e-20 85.5 28NV7@1|root,2ZBTD@2|Bacteria,1RAH4@1224|Proteobacteria,1S2YP@1236|Gammaproteobacteria,1WY67@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_820214_2 616991.JPOO01000003_gene799 6.32e-120 363.0 COG3547@1|root,COG3547@2|Bacteria,4NGED@976|Bacteroidetes,1HYRZ@117743|Flavobacteriia,23ID0@178469|Arenibacter 976|Bacteroidetes L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_395351_1 1112212.JH584235_gene361 8.78e-20 94.0 COG4774@1|root,COG4774@2|Bacteria,1QPVC@1224|Proteobacteria,2U4WC@28211|Alphaproteobacteria,2K32N@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_460972_1 1121935.AQXX01000132_gene2686 9.39e-147 434.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XICM@135619|Oceanospirillales 135619|Oceanospirillales V (ABC) transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_853118_1 395961.Cyan7425_4158 1.29e-42 142.0 2DRRT@1|root,32URI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_134064_1 94624.Bpet0922 5.4e-38 136.0 COG1296@1|root,COG1296@2|Bacteria,1MVGN@1224|Proteobacteria,2VPFP@28216|Betaproteobacteria,3T286@506|Alcaligenaceae 28216|Betaproteobacteria E branched-chain amino acid permease (azaleucine resistance) azlC - - - - - - - - - - - AzlC k59_231931_1 1410668.JNKC01000007_gene796 1.07e-18 92.4 COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,36EYT@31979|Clostridiaceae 186801|Clostridia G Glycosyltransferase 36 associated ndvB - - - - - - - - - - - DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_853120_1 1121875.KB907546_gene2203 3.09e-71 225.0 COG2367@1|root,COG2367@2|Bacteria,4NE3C@976|Bacteroidetes,1HZYJ@117743|Flavobacteriia 976|Bacteroidetes V beta-lactamase per1 - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_1016305_1 502025.Hoch_1969 9.01e-21 96.7 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MJD@68525|delta/epsilon subdivisions,2WJC4@28221|Deltaproteobacteria,2YXYZ@29|Myxococcales 28221|Deltaproteobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family epsN - 2.6.1.102 ko:K13010,ko:K19430 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_787460_1 1166130.H650_11985 2.88e-122 364.0 COG3287@1|root,COG3287@2|Bacteria,1MVUZ@1224|Proteobacteria,1RY7N@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT GfdT protein - - - - - - - - - - - - FIST,FIST_C k59_787460_2 1167006.UWK_01273 1.99e-80 268.0 COG0840@1|root,COG4191@1|root,COG0840@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2MPRX@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg k59_787460_3 1168067.JAGP01000001_gene1618 3.32e-216 626.0 COG3930@1|root,COG3930@2|Bacteria,1PYFH@1224|Proteobacteria,1RP1J@1236|Gammaproteobacteria,4620J@72273|Thiotrichales 72273|Thiotrichales S DUF1704 - - - - - - - - - - - - DUF1704,FGase k59_787460_4 1232683.ADIMK_3507 1.09e-171 488.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,4651A@72275|Alteromonadaceae 1236|Gammaproteobacteria H Belongs to the prokaryotic GSH synthase family - - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_787460_5 640513.Entas_4304 9.41e-22 90.1 COG3085@1|root,COG3085@2|Bacteria,1RD72@1224|Proteobacteria,1S3NW@1236|Gammaproteobacteria,3X2GM@547|Enterobacter 1236|Gammaproteobacteria S Protein of unknown function, DUF yifE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0044424,GO:0044444,GO:0044464,GO:0051276,GO:0071840 - ko:K09897 - - - - ko00000 - - - DUF413 k59_787460_6 675813.VIB_002689 5.68e-63 207.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1XUTM@135623|Vibrionales 135623|Vibrionales K Transcriptional regulator hdfR - - - - - - - - - - - HTH_1,LysR_substrate k59_787460_7 768671.ThimaDRAFT_3837 1.35e-36 129.0 2E94J@1|root,333DE@2|Bacteria,1N7Q9@1224|Proteobacteria,1SEA8@1236|Gammaproteobacteria,1WYCC@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_787460_8 991905.SL003B_2904 3.06e-130 380.0 COG1275@1|root,COG1275@2|Bacteria,1MVPG@1224|Proteobacteria,2U072@28211|Alphaproteobacteria,4BSFS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Voltage-dependent anion channel tehA - - ko:K03304 - - - - ko00000,ko02000 2.A.16.1 - - SLAC1 k59_787460_9 1123393.KB891316_gene1793 1.31e-154 496.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GAF_2,GGDEF,PAS_4,PAS_9 k59_787460_10 946483.Cenrod_1795 1.19e-103 315.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VI1Z@28216|Betaproteobacteria,4AC77@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_754603_2 1009370.ALO_15232 1.33e-154 451.0 28MXM@1|root,2ZB4M@2|Bacteria,1UYF1@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_591367_1 105559.Nwat_0841 1.08e-64 211.0 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales 135613|Chromatiales M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_559034_1 1168034.FH5T_18985 5.75e-120 365.0 COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,2FNBG@200643|Bacteroidia 976|Bacteroidetes M transglycosylase ponA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_231944_1 555088.DealDRAFT_1727 2.6e-53 180.0 COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,247SM@186801|Clostridia 186801|Clostridia E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_101243_1 1056512.D515_01159 6.56e-75 238.0 COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,1XUE5@135623|Vibrionales 135623|Vibrionales P Catalyzes the sodium-dependent transport of glutamate gltS - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter k59_330177_1 76114.ebA2933 7.26e-12 68.6 COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,2KVUV@206389|Rhodocyclales 206389|Rhodocyclales C formate dehydrogenase fdhC - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB k59_395373_1 992406.RIA_1861 4.12e-20 92.8 COG1253@1|root,COG1253@2|Bacteria,4NDZ7@976|Bacteroidetes,1HXF3@117743|Flavobacteriia 976|Bacteroidetes S gliding motility-associated protein GldE gldE - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1016320_1 1335760.ASTG01000016_gene119 3.17e-67 222.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2K6JI@204457|Sphingomonadales 204457|Sphingomonadales T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_8,Trans_reg_C k59_460994_1 273121.WS1857 3.02e-32 121.0 COG1342@1|root,COG1342@2|Bacteria,1Q42A@1224|Proteobacteria,42XGI@68525|delta/epsilon subdivisions,2YSZ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function DUF134 - - - - - - - - - - - - DUF134 k59_297133_1 1121015.N789_01825 6.49e-29 119.0 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria,1X4RC@135614|Xanthomonadales 135614|Xanthomonadales N transport system involved in gliding motility, auxiliary component - - - - - - - - - - - - ABC_transp_aux k59_330945_1 1487923.DP73_17860 1.05e-119 352.0 COG1740@1|root,COG1740@2|Bacteria,1TZZD@1239|Firmicutes,2489B@186801|Clostridia,261I4@186807|Peptococcaceae 186801|Clostridia C TIGRFAM hydrogenase (NiFe) small subunit (hydA) - - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_68992_1 443143.GM18_2920 6.43e-90 272.0 COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,42RZI@68525|delta/epsilon subdivisions,2WN9Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Mrr N-terminal domain - - - ko:K07448 - - - - ko00000,ko02048 - - - Mrr_N,Mrr_cat k59_363276_1 292415.Tbd_1072 2.11e-94 296.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VS7B@28216|Betaproteobacteria 28216|Betaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2 k59_951770_1 1069534.LRC_17590 0.000665 42.4 COG1309@1|root,COG1309@2|Bacteria,1V1R2@1239|Firmicutes,4HFW2@91061|Bacilli,3F6PE@33958|Lactobacillaceae 91061|Bacilli K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_8,TetR_N k59_232633_1 1410668.JNKC01000006_gene743 1.45e-33 126.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,36DCB@31979|Clostridiaceae 186801|Clostridia C glycyl-radical enzyme activating protein family act - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_232633_2 882.DVU_2148 4.47e-29 118.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WKVE@28221|Deltaproteobacteria,2M7ZJ@213115|Desulfovibrionales 28221|Deltaproteobacteria S Transporter-associated region - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_527067_1 1168034.FH5T_07335 7.98e-219 617.0 COG0821@1|root,COG0821@2|Bacteria,4NE63@976|Bacteroidetes,2FM97@200643|Bacteroidia 976|Bacteroidetes I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_984247_1 56780.SYN_00126 3.05e-112 333.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MR4Y@213462|Syntrophobacterales 28221|Deltaproteobacteria NU Type IV secretion-system coupling protein DNA-binding domain pilT1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_264900_1 933262.AXAM01000025_gene3417 7.9e-155 454.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,42N42@68525|delta/epsilon subdivisions,2WK62@28221|Deltaproteobacteria,2MI73@213118|Desulfobacterales 28221|Deltaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_199693_1 765914.ThisiDRAFT_1416 9.21e-63 212.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWQV@135613|Chromatiales 135613|Chromatiales L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_984248_1 13689.BV96_03981 2.32e-05 53.1 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria,2K3NU@204457|Sphingomonadales 204457|Sphingomonadales L Protein involved in DNA binding and transposition, DNA-mediated - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_956690_1 911045.PSE_0075 1.51e-11 69.3 COG4246@1|root,COG4246@2|Bacteria,1N7Y1@1224|Proteobacteria,2TTZW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - Phytase-like k59_891461_1 583355.Caka_2634 1.42e-51 180.0 COG1502@1|root,COG1502@2|Bacteria,46TDH@74201|Verrucomicrobia,3K9QJ@414999|Opitutae 414999|Opitutae I PFAM phospholipase D Transphosphatidylase - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_565386_1 1089552.KI911559_gene2772 2.25e-66 204.0 COG0784@1|root,COG0784@2|Bacteria,1QU3I@1224|Proteobacteria,2TVXW@28211|Alphaproteobacteria,2JYY8@204441|Rhodospirillales 204441|Rhodospirillales T cheY-homologous receiver domain - - - ko:K11443 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko02022 - - - Hpt,PAS_8,Response_reg k59_565386_2 856793.MICA_1955 2.97e-18 84.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,4BRP5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T diguanylate cyclase pleD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_956695_1 1121342.AUCO01000002_gene869 8.2e-08 56.6 2EVHJ@1|root,33NXY@2|Bacteria,1VNFY@1239|Firmicutes,24QJV@186801|Clostridia,36MVF@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_956695_2 632245.CLP_2968 3.29e-17 82.0 COG4512@1|root,COG4512@2|Bacteria,1VF1N@1239|Firmicutes,24SCM@186801|Clostridia,36HYN@31979|Clostridiaceae 186801|Clostridia KOT PFAM Accessory gene regulator B - - - ko:K07813 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001,ko01002 - - - AgrB k59_369234_1 314278.NB231_13571 6.41e-61 192.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,1WWRQ@135613|Chromatiales 135613|Chromatiales S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_990142_1 563040.Saut_0748 5.84e-53 169.0 COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42THI@68525|delta/epsilon subdivisions,2YPYY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterised protein family (UPF0153) - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_990142_2 929558.SMGD1_0371 4.87e-31 115.0 COG4123@1|root,COG4123@2|Bacteria,1RDSC@1224|Proteobacteria,42RIN@68525|delta/epsilon subdivisions,2YP8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S methyltransferase - - - - - - - - - - - - MTS k59_792017_1 1168034.FH5T_16945 2.55e-168 483.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT,Cytochrom_c3_2 k59_173282_1 153948.NAL212_1170 1.6e-20 89.0 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,2VSVR@28216|Betaproteobacteria,3739I@32003|Nitrosomonadales 28216|Betaproteobacteria NU PFAM Pilus assembly protein pilP - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_173282_2 232721.Ajs_0732 4.42e-22 92.8 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,4AANW@80864|Comamonadaceae 28216|Betaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_597832_1 926550.CLDAP_40630 1.86e-23 97.4 COG0800@1|root,COG0800@2|Bacteria,2G8MI@200795|Chloroflexi 200795|Chloroflexi G KDPG and KHG aldolase - - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_467286_1 472759.Nhal_1884 9.94e-86 266.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WZYK@135613|Chromatiales 135613|Chromatiales H Belongs to the RtcB family - - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_107984_1 1294143.H681_02410 3.76e-80 280.0 COG0834@1|root,COG5001@1|root,COG0834@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_9,SBP_bac_3 k59_792023_1 1335757.SPICUR_07745 3.3e-96 293.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_956706_1 1121931.AUHG01000012_gene2489 3.03e-67 225.0 COG0419@1|root,COG0613@1|root,COG0419@2|Bacteria,COG0613@2|Bacteria,4NIW1@976|Bacteroidetes,1HZ4V@117743|Flavobacteriia 976|Bacteroidetes L ATPase involved in DNA repair - - - - - - - - - - - - - k59_826440_1 1168034.FH5T_16740 7.66e-184 522.0 COG0507@1|root,COG0507@2|Bacteria,4NDYK@976|Bacteroidetes,2FNT1@200643|Bacteroidia 976|Bacteroidetes L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member recD2_2 - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - AAA_30,UvrD_C_2 k59_826440_2 926549.KI421517_gene1343 3.62e-08 54.7 COG1234@1|root,COG1234@2|Bacteria,4NE1K@976|Bacteroidetes,47KGX@768503|Cytophagia 976|Bacteroidetes S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_337134_1 768671.ThimaDRAFT_2471 9.68e-60 199.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1X08U@135613|Chromatiales 135613|Chromatiales S Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_630495_1 521674.Plim_0635 5.29e-43 154.0 COG0438@1|root,COG0438@2|Bacteria,2J05U@203682|Planctomycetes 203682|Planctomycetes M Glycosyl transferase 4-like - - - - - - - - - - - - Glyco_trans_4_2,Glycos_transf_1 k59_760341_1 506534.Rhein_1816 2.24e-51 183.0 COG4615@1|root,COG4615@2|Bacteria,1MVIC@1224|Proteobacteria,1RMYK@1236|Gammaproteobacteria,1WWNW@135613|Chromatiales 135613|Chromatiales PQ pfam abc - - - - - - - - - - - - ABC_tran k59_401210_1 1121403.AUCV01000042_gene141 9.29e-06 52.4 COG3204@1|root,COG3419@1|root,COG3204@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WJYB@28221|Deltaproteobacteria,2MPX7@213118|Desulfobacterales 28221|Deltaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_303055_2 1341181.FLJC2902T_24890 2.29e-55 187.0 COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,1HX8I@117743|Flavobacteriia,2NV6I@237|Flavobacterium 976|Bacteroidetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_108465_1 1442598.JABW01000025_gene1084 1.05e-45 156.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N1I@68525|delta/epsilon subdivisions,2YMA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome ccpA - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_108465_2 1165841.SULAR_03103 3.07e-249 697.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,42N0P@68525|delta/epsilon subdivisions,2YN14@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C UPF0313 protein - - - - - - - - - - - - Radical_SAM,Radical_SAM_N k59_990796_2 1125863.JAFN01000001_gene2449 2.36e-38 139.0 COG1064@1|root,COG1064@2|Bacteria,1QVIH@1224|Proteobacteria,42NMX@68525|delta/epsilon subdivisions,2WJGB@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Alcohol dehydrogenase GroES-like domain bamQ - 1.1.1.368 ko:K07538 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05581 RC00850 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_238580_1 1163617.SCD_n00462 5e-102 304.0 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria 28216|Betaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_792402_1 945713.IALB_1631 1.71e-75 242.0 COG1008@1|root,COG1008@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoM2 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1022675_1 631362.Thi970DRAFT_04762 8.58e-102 304.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1WWWJ@135613|Chromatiales 135613|Chromatiales O HflC and HflK could encode or regulate a protease - - - - - - - - - - - - Band_7 k59_433930_2 1123401.JHYQ01000026_gene3259 1.87e-33 130.0 COG1009@1|root,COG1009@2|Bacteria,1R5G2@1224|Proteobacteria,1RN3G@1236|Gammaproteobacteria,463IQ@72273|Thiotrichales 72273|Thiotrichales CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - - - - - - - - - - - Proton_antipo_M,Proton_antipo_N k59_760821_1 1123355.JHYO01000008_gene2681 5.43e-29 119.0 COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBR@1224|Proteobacteria,2U1RE@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Sigma factor PP2C-like phosphatases rsbU - - - - - - - - - - - GAF,GAF_2,HATPase_c_2,SpoIIE k59_760821_2 1244869.H261_16957 2.01e-24 95.9 COG1366@1|root,COG1366@2|Bacteria,1N6U1@1224|Proteobacteria,2UFPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Belongs to the anti-sigma-factor antagonist family - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS,STAS_2 k59_206257_1 1049564.TevJSym_as00150 7.88e-76 249.0 COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1JAB5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acid phosphatase homologues lssY - - ko:K03975 - - - - ko00000 - - - LssY_C,PAP2,SNARE_assoc k59_565969_1 749222.Nitsa_0164 3.81e-99 313.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 k59_859117_1 394.NGR_c35040 8.77e-30 117.0 COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2U4IW@28211|Alphaproteobacteria,4BA8I@82115|Rhizobiaceae 28211|Alphaproteobacteria S Predicted metal-binding integral membrane protein (DUF2182) - - - - - - - - - - - - DUF2182 k59_826959_1 1049564.TevJSym_ap00050 4.91e-107 335.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_173767_1 694427.Palpr_2359 6.37e-33 123.0 COG0226@1|root,COG0226@2|Bacteria 2|Bacteria P phosphate ion binding - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PorP_SprF k59_173767_2 694427.Palpr_2358 5.53e-50 179.0 COG3291@1|root,COG3291@2|Bacteria,4P9ST@976|Bacteroidetes,2G02B@200643|Bacteroidia 976|Bacteroidetes S C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,PKD k59_369835_1 1121918.ARWE01000001_gene2949 5.15e-94 294.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,43SU0@69541|Desulfuromonadales 28221|Deltaproteobacteria H thiamine pyrophosphate protein TPP binding domain protein - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1022694_1 998674.ATTE01000001_gene3539 8.28e-94 285.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,1RP49@1236|Gammaproteobacteria,461NK@72273|Thiotrichales 72273|Thiotrichales E Saccharopine dehydrogenase C-terminal domain - - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_270413_1 94624.Bpet4909 4.12e-95 287.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,3T2KK@506|Alcaligenaceae 28216|Betaproteobacteria F dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_664287_1 1096930.L284_04370 5.54e-06 54.7 COG1572@1|root,COG1572@2|Bacteria,1QUSN@1224|Proteobacteria,2TW61@28211|Alphaproteobacteria,2KEBS@204457|Sphingomonadales 204457|Sphingomonadales NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - - k59_41187_1 283942.IL0427 9.08e-41 140.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,2QFXB@267893|Idiomarinaceae 1236|Gammaproteobacteria K Belongs to the MraZ family mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_533685_1 331678.Cphamn1_2543 3.05e-115 360.0 COG0610@1|root,COG0610@2|Bacteria 2|Bacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_467807_1 760117.JN27_12095 4.9e-65 214.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4733N@75682|Oxalobacteraceae 28216|Betaproteobacteria T Sigma-54 interaction domain ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_925774_1 1123252.ATZF01000031_gene1916 6.27e-16 74.3 COG4392@1|root,COG4392@2|Bacteria,1VBUN@1239|Firmicutes,4HKJZ@91061|Bacilli,27CGZ@186824|Thermoactinomycetaceae 91061|Bacilli S Branched-chain amino acid transport protein (AzlD) - - - - - - - - - - - - AzlD k59_792414_2 880073.Calab_3570 3.95e-117 356.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria 2|Bacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_565989_1 1408473.JHXO01000013_gene594 5.67e-98 297.0 COG1350@1|root,COG1350@2|Bacteria,4PKSY@976|Bacteroidetes,2FMFD@200643|Bacteroidia 976|Bacteroidetes E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_41189_1 326298.Suden_1944 5.33e-47 163.0 COG0475@1|root,COG0475@2|Bacteria,1RFKE@1224|Proteobacteria,43B2P@68525|delta/epsilon subdivisions,2YT5F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_41189_2 1442598.JABW01000028_gene979 0.000741 42.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2YM8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_598495_1 929558.SMGD1_1901 1.07e-84 260.0 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QYV@68525|delta/epsilon subdivisions,2YNW5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Jag_N - - - ko:K06346 - - - - ko00000 - - - Jag_N k59_173780_1 59374.Fisuc_3113 3.64e-23 101.0 COG0500@1|root,COG2021@1|root,COG2021@2|Bacteria,COG2226@2|Bacteria 2|Bacteria Q methyltransferase metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1,MetW k59_631170_1 762903.Pedsa_0083 3.47e-37 131.0 COG1943@1|root,COG1943@2|Bacteria,4NJZI@976|Bacteroidetes,1J0EE@117747|Sphingobacteriia 976|Bacteroidetes L PFAM Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_859145_1 387093.SUN_0373 1.71e-08 55.1 2DYZP@1|root,34BX4@2|Bacteria,1NQ0Q@1224|Proteobacteria,42UWX@68525|delta/epsilon subdivisions,2YQ5F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_401777_1 1123070.KB899247_gene1474 4.61e-54 185.0 COG1190@1|root,COG1190@2|Bacteria,46TIA@74201|Verrucomicrobia,2ITHH@203494|Verrucomicrobiae 203494|Verrucomicrobiae J tRNA synthetases class II (D, K and N) lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_925779_1 1267533.KB906734_gene4066 2.71e-11 73.2 COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria 57723|Acidobacteria KU WD40 domain protein beta Propeller - - - - - - - - - - - - PD40,Trans_reg_C k59_206291_1 247633.GP2143_10907 6.91e-65 216.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1J4PM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_533696_1 314278.NB231_00660 1.21e-76 238.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1WX0P@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_925781_1 469617.FUAG_01034 1.88e-10 60.5 COG2868@1|root,COG2868@2|Bacteria,37ACN@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score 8.96 - - - ko:K07584 - - - - ko00000 - - - Peptidase_Prp k59_925781_2 1319815.HMPREF0202_00387 5.55e-45 147.0 COG0261@1|root,COG0261@2|Bacteria,37AD7@32066|Fusobacteria 32066|Fusobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_925781_3 1410653.JHVC01000006_gene148 2.33e-35 127.0 COG4939@1|root,COG4939@2|Bacteria,1VJ2S@1239|Firmicutes,24M0K@186801|Clostridia,36MA1@31979|Clostridiaceae 186801|Clostridia S FMN_bind - - - - - - - - - - - - FMN_bind k59_433971_1 96561.Dole_0341 6.97e-63 207.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MHTP@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_728379_1 1504672.669783786 2.21e-77 242.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,4ACKS@80864|Comamonadaceae 28216|Betaproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 k59_369864_1 748247.AZKH_1671 2.9e-98 300.0 COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria 28216|Betaproteobacteria M TIGRFAM efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_238630_1 1144313.PMI10_02376 5.11e-32 127.0 COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,4NEXP@976|Bacteroidetes,1HXBK@117743|Flavobacteriia,2NUQD@237|Flavobacterium 976|Bacteroidetes C Cytochrome C oxidase, cbb3-type, subunit III nirK - 1.7.2.1 ko:K00368,ko:K00405 ko00190,ko00910,ko01100,ko01120,ko02020,map00190,map00910,map01100,map01120,map02020 M00156,M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cu-oxidase,Cu-oxidase_3,Cytochrom_C,Cytochrome_CBB3 k59_1022724_1 713586.KB900536_gene1203 4.17e-62 211.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales 135613|Chromatiales T Belongs to the PEP-utilizing enzyme family - - 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_664324_1 1122236.KB905141_gene896 1.48e-23 103.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VMQS@28216|Betaproteobacteria,2KKDD@206350|Nitrosomonadales 206350|Nitrosomonadales E PFAM extracellular solute-binding protein family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_925785_1 1487953.JMKF01000045_gene2836 1.16e-47 177.0 COG1404@1|root,COG1404@2|Bacteria,1GBNY@1117|Cyanobacteria 1117|Cyanobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_637019_1 1537917.JU82_09900 1.45e-136 396.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,42MMG@68525|delta/epsilon subdivisions,2YMCT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_637019_2 563040.Saut_1706 3.93e-136 392.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2YM87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_637019_3 709032.Sulku_0599 2.47e-40 138.0 COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VD0@68525|delta/epsilon subdivisions,2YQ93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_407329_2 519989.ECTPHS_00230 6.79e-49 162.0 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0209 Ribonucleotide reductase, alpha subunit nrdJb - - - - - - - - - - - - k59_767057_1 563040.Saut_1426 2.99e-14 67.4 2AQJX@1|root,31FST@2|Bacteria,1QDI5@1224|Proteobacteria,432NI@68525|delta/epsilon subdivisions,2YSH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_767057_2 929558.SMGD1_0041 4.38e-182 519.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2YN96@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Peptidase M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_1028135_1 1049564.TevJSym_ap00150 2.15e-200 582.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1J55U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase pcoA - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_1028135_2 1172190.M947_11445 8.67e-37 135.0 COG3667@1|root,COG3667@2|Bacteria,1MXW6@1224|Proteobacteria,42SFY@68525|delta/epsilon subdivisions,2YPMX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Copper resistance protein B precursor (CopB) - - - ko:K07233 - - - - ko00000 - - - CopB k59_1028135_3 387093.SUN_0785 7.87e-31 118.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2YMQ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_767063_1 673860.AciM339_1081 1.63e-26 108.0 COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,3F2N6@33867|unclassified Euryarchaeota 28890|Euryarchaeota J tRNA synthetases class I (W and Y) trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF692.Mbar_A1374 tRNA-synt_1b k59_931252_1 1537917.JU82_01905 2.67e-90 266.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,42R5N@68525|delta/epsilon subdivisions,2YNX0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_472488_1 326298.Suden_1677 1.51e-15 75.9 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2YNID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S acid membrane antigen A amaA - - - - - - - - - - - AI-2E_transport k59_472488_2 1249480.B649_09410 4.44e-155 440.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2YMER@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_472488_4 1283300.ATXB01000001_gene1563 3.84e-06 48.5 2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria,1SCI0@1236|Gammaproteobacteria,1XFNR@135618|Methylococcales 135618|Methylococcales S F0F1-ATPase subunit - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_147407_1 749222.Nitsa_2116 1.08e-184 529.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_701885_1 709032.Sulku_0142 1.74e-101 325.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2YMTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_767069_1 1042375.AFPL01000037_gene1474 1.91e-32 115.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,466UW@72275|Alteromonadaceae 1236|Gammaproteobacteria J Ribosomal protein L17 rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_767069_2 1244869.H261_03848 9.93e-82 251.0 COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,2TVNY@28211|Alphaproteobacteria,2JS9Y@204441|Rhodospirillales 204441|Rhodospirillales S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_637039_1 1499967.BAYZ01000017_gene6240 4.37e-79 254.0 COG2942@1|root,COG2942@2|Bacteria 2|Bacteria G 2-epimerase - - 5.1.3.11 ko:K16213 - - R01445,R10810 RC00289 ko00000,ko01000 - - - GlcNAc_2-epim,STAS k59_80613_1 572477.Alvin_3038 4.04e-11 65.1 COG3944@1|root,COG3944@2|Bacteria,1NBT9@1224|Proteobacteria,1SR1P@1236|Gammaproteobacteria,1X13J@135613|Chromatiales 135613|Chromatiales M biosynthesis protein - - - - - - - - - - - - - k59_80614_1 324925.Ppha_0818 9.5e-85 253.0 COG1592@1|root,COG1592@2|Bacteria,1FE9N@1090|Chlorobi 1090|Chlorobi C PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_308765_1 879212.DespoDRAFT_00272 6.48e-31 125.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2MHQJ@213118|Desulfobacterales 28221|Deltaproteobacteria OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_767074_1 631362.Thi970DRAFT_02439 1.63e-98 320.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_308769_1 1528106.JRJE01000004_gene461 1.07e-32 127.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,2JR96@204441|Rhodospirillales 204441|Rhodospirillales E aminopeptidase N pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_767079_1 1120953.AUBH01000008_gene207 1.28e-99 301.0 COG1638@1|root,COG1638@2|Bacteria,1P3MK@1224|Proteobacteria,1SFVP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_963234_1 272942.RCAP_rcc01378 1.02e-116 345.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRJV@28211|Alphaproteobacteria,1FBHX@1060|Rhodobacter 28211|Alphaproteobacteria C Belongs to the aldehyde dehydrogenase family ssdA - - - - - - - - - - - Aldedh k59_472499_1 1282360.ABAC460_19840 5.36e-69 224.0 COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria 1224|Proteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM k59_637048_1 765911.Thivi_1311 1.1e-129 382.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_571349_1 1127673.GLIP_2924 3.4e-13 70.5 2BWPY@1|root,2Z8BI@2|Bacteria,1QHHB@1224|Proteobacteria,1RP8D@1236|Gammaproteobacteria,4657P@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_767101_1 1123487.KB892834_gene3058 3.68e-20 89.0 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,2VNH9@28216|Betaproteobacteria,2KU7D@206389|Rhodocyclales 206389|Rhodocyclales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_767101_2 998674.ATTE01000001_gene2091 5.45e-48 164.0 COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,1T9Q0@1236|Gammaproteobacteria,461SP@72273|Thiotrichales 72273|Thiotrichales H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_275288_2 1537917.JU82_09525 6.48e-43 140.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,42TGC@68525|delta/epsilon subdivisions,2YQA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_275288_3 709032.Sulku_0202 1.73e-55 177.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2YN2M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_996516_1 469618.FVAG_02715 1.61e-53 177.0 COG0681@1|root,COG0681@2|Bacteria,378A6@32066|Fusobacteria 32066|Fusobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_996516_2 1095747.HMPREF1049_0080 7.36e-41 138.0 COG0335@1|root,COG0335@2|Bacteria,37A44@32066|Fusobacteria 32066|Fusobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_472515_1 1499684.CCNP01000019_gene2005 4.77e-83 253.0 COG1346@1|root,COG1346@2|Bacteria,1TRGN@1239|Firmicutes,24AGM@186801|Clostridia,36HZR@31979|Clostridiaceae 186801|Clostridia M PFAM LrgB family protein lrgB - - - - - - - - - - - LrgB k59_472515_2 1476973.JMMB01000007_gene1161 3.05e-08 53.5 COG1380@1|root,COG1380@2|Bacteria,1VEN4@1239|Firmicutes,25JC7@186801|Clostridia,25RXC@186804|Peptostreptococcaceae 186801|Clostridia S LrgA family - - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA k59_864668_2 994479.GL877878_gene2282 8.03e-29 117.0 COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4E00A@85010|Pseudonocardiales 201174|Actinobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_212376_1 338969.Rfer_0382 1.92e-07 53.1 COG0778@1|root,COG0778@2|Bacteria,1RDJ6@1224|Proteobacteria,2VNI9@28216|Betaproteobacteria,4AEQI@80864|Comamonadaceae 28216|Betaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_46276_1 1049564.TevJSym_ac01740 1.09e-67 229.0 28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phosphoenolpyruvate carboxykinase (diphosphate) activity - - 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 - R00346 RC02741 ko00000,ko00001,ko01000 - - - - k59_604595_1 1165841.SULAR_00905 5.27e-08 53.5 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2YMTD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the FtsK SpoIIIE SftA family ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_10249_1 749222.Nitsa_0421 2.81e-70 230.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2YMVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_996521_1 631362.Thi970DRAFT_03256 1.85e-63 219.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1S0W3@1236|Gammaproteobacteria,1WX5N@135613|Chromatiales 135613|Chromatiales KL DNA RNA helicase - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_507269_1 1249627.D779_2829 3.24e-54 182.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_10250_1 1123253.AUBD01000007_gene706 5.64e-12 65.9 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,1X4PF@135614|Xanthomonadales 135614|Xanthomonadales I fatty acid desaturase desC - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_10250_2 1101195.Meth11DRAFT_1307 8.14e-54 174.0 COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,2VTSY@28216|Betaproteobacteria,2KMTG@206350|Nitrosomonadales 206350|Nitrosomonadales M Lipocalin-like domain - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_796385_1 572544.Ilyop_0150 9.92e-35 126.0 COG2137@1|root,COG2137@2|Bacteria,3794Z@32066|Fusobacteria 32066|Fusobacteria S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_796385_2 572544.Ilyop_0151 9.08e-80 246.0 COG0204@1|root,COG0204@2|Bacteria,379EN@32066|Fusobacteria 32066|Fusobacteria I 1-acyl-sn-glycerol-3-phosphate acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_796385_3 888055.HMPREF9015_01503 7.15e-78 253.0 COG1882@1|root,COG1882@2|Bacteria,378S4@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score 9.97 pflB - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_701922_2 749222.Nitsa_0401 9.87e-61 201.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2YN96@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Peptidase M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_796386_1 1129794.C427_0215 3.55e-124 369.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,465QH@72275|Alteromonadaceae 1236|Gammaproteobacteria CP COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_767117_1 1249627.D779_4054 1.19e-118 357.0 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Alkaline phosphatase pafA - - - - - - - - - - - Phosphodiest k59_571376_1 1168034.FH5T_05930 1.11e-94 303.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,2FMH3@200643|Bacteroidia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran,OEP k59_637075_1 396588.Tgr7_0491 2.75e-20 86.3 COG1247@1|root,COG1247@2|Bacteria 2|Bacteria M phosphinothricin N-acetyltransferase activity yafP - - ko:K03830 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_10 k59_796396_1 1249480.B649_04880 7.19e-71 220.0 COG1309@1|root,COG1309@2|Bacteria,1R52P@1224|Proteobacteria,42VHH@68525|delta/epsilon subdivisions,2YQ3V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Bacterial transcriptional repressor - - - - - - - - - - - - TetR,TetR_N k59_539476_2 272942.RCAP_rcc03083 5.35e-09 52.0 COG4890@1|root,COG4890@2|Bacteria,1NGDQ@1224|Proteobacteria,2UJD5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cyd operon protein YbgT - - 1.10.3.14 ko:K00424 ko00190,ko02020,map00190,map02020 M00153 - - ko00000,ko00001,ko01000 3.D.4.3 - - YbgT_YccB k59_539476_3 1121035.AUCH01000012_gene2938 5.82e-217 605.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,2KVCB@206389|Rhodocyclales 206389|Rhodocyclales C oxidase, subunit - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_539476_4 1121035.AUCH01000012_gene2939 8.5e-296 817.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,2KVQY@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome bd-type quinol oxidase, subunit 1 - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_539476_6 497321.C664_17355 5.01e-36 127.0 COG1433@1|root,COG1433@2|Bacteria,1N7S0@1224|Proteobacteria,2WG9K@28216|Betaproteobacteria 28216|Betaproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_1028706_2 563040.Saut_0291 1.44e-63 198.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2YMCY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_1028707_1 715226.ABI_28550 1.14e-50 179.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TUA9@28211|Alphaproteobacteria,2KFV0@204458|Caulobacterales 204458|Caulobacterales I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_702590_1 1182590.BN5_03760 1.13e-30 120.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1RNRG@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_833244_1 398525.KB900701_gene993 6.44e-99 298.0 COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,1MUET@1224|Proteobacteria,2TQMZ@28211|Alphaproteobacteria,3JR4J@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Rubrerythrin MA20_19235 - - - - - - - - - - - Rubrerythrin k59_833244_2 935261.JAGL01000011_gene2053 7.02e-07 49.7 28I53@1|root,2Z88I@2|Bacteria,1NE5N@1224|Proteobacteria,2TTBB@28211|Alphaproteobacteria,43JNR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3750) - - - - - - - - - - - - DUF3750 k59_797093_1 96561.Dole_0063 5.25e-53 179.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42PWY@68525|delta/epsilon subdivisions,2WKFX@28221|Deltaproteobacteria,2MJ9Z@213118|Desulfobacterales 28221|Deltaproteobacteria H MoeA N-terminal region (domain I and II) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_46908_1 1283337.PORTL_BPHA1 2.94e-21 94.7 4QAZJ@10239|Viruses,4QX3R@35237|dsDNA viruses no RNA stage,4QPFF@28883|Caudovirales,4QJS9@10662|Myoviridae 10662|Myoviridae S virion assembly - - - - - - - - - - - - - k59_898643_1 857087.Metme_2773 4.35e-78 236.0 COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,1S3PE@1236|Gammaproteobacteria,1XE1Z@135618|Methylococcales 135618|Methylococcales T response regulator - - - ko:K15012 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg k59_670757_1 701176.VIBRN418_16366 5.23e-62 198.0 2D370@1|root,32TED@2|Bacteria,1N0JG@1224|Proteobacteria,1SQTP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_540124_1 572544.Ilyop_0495 4.42e-13 68.6 COG0323@1|root,COG0323@2|Bacteria,378NQ@32066|Fusobacteria 32066|Fusobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_540124_2 572544.Ilyop_0496 5.73e-72 220.0 COG1576@1|root,COG1576@2|Bacteria,37A2K@32066|Fusobacteria 32066|Fusobacteria J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_473230_2 1347393.HG726020_gene980 4.79e-109 327.0 COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,2FQ3G@200643|Bacteroidia,4ANW6@815|Bacteroidaceae 976|Bacteroidetes P Arylsulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_514479_4 765911.Thivi_2848 4.43e-33 116.0 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1WZ1M@135613|Chromatiales 135613|Chromatiales J 50S ribosomal protein L31 rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_514479_5 398579.Spea_2570 2.25e-06 55.1 COG2885@1|root,COG2885@2|Bacteria,1PGGZ@1224|Proteobacteria,1RNFU@1236|Gammaproteobacteria,2Q9B1@267890|Shewanellaceae 1236|Gammaproteobacteria M Belongs to the ompA family motY - - ko:K21218 ko02040,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_514479_7 1265503.KB905189_gene4438 6.31e-24 94.7 2E9D3@1|root,333KN@2|Bacteria,1N8RG@1224|Proteobacteria,1SDDN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_514479_9 338966.Ppro_1054 2.36e-57 182.0 COG1733@1|root,COG1733@2|Bacteria,1N0WG@1224|Proteobacteria,431IT@68525|delta/epsilon subdivisions,2WW6R@28221|Deltaproteobacteria 28221|Deltaproteobacteria K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_514479_12 41431.PCC8801_3365 5.03e-37 132.0 COG3153@1|root,COG3153@2|Bacteria,1GK4X@1117|Cyanobacteria,3KIFY@43988|Cyanothece 1117|Cyanobacteria S PFAM GCN5-related N-acetyltransferase - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_9 k59_774235_1 1112217.PPL19_05700 1.13e-87 264.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S abc transporter atp-binding protein lptB GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_774235_2 95619.PM1_0206370 2.27e-44 164.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_774243_1 29581.BW37_04559 1.99e-30 117.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,472AF@75682|Oxalobacteraceae 28216|Betaproteobacteria O Peptidase family U32 yhbU - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_774243_2 1265313.HRUBRA_00591 2.9e-29 113.0 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,1J5V7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Peptidase family U32 yhbV - - - - - - - - - - - Peptidase_U32 k59_803598_1 749222.Nitsa_0080 2.15e-25 103.0 COG3677@1|root,COG3677@2|Bacteria,1NPAK@1224|Proteobacteria,42T3G@68525|delta/epsilon subdivisions,2YPID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Transposase - - - - - - - - - - - - - k59_803598_2 1287276.X752_23765 7.21e-42 144.0 COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,43K34@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Hydrogenase urease accessory protein hupE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03192 - - - - ko00000 - - - HupE_UreJ k59_1034916_1 1165841.SULAR_03522 1.22e-66 204.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2YPJX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_187075_1 98439.AJLL01000005_gene4452 9.74e-67 213.0 COG0581@1|root,COG0581@2|Bacteria,1G2GA@1117|Cyanobacteria,1JHYX@1189|Stigonemataceae 1117|Cyanobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_187075_2 864702.OsccyDRAFT_4140 3.79e-20 88.6 COG0573@1|root,COG0573@2|Bacteria,1G1JR@1117|Cyanobacteria,1H73A@1150|Oscillatoriales 1117|Cyanobacteria P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_53309_1 765912.Thimo_2086 2.44e-54 176.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1WXW6@135613|Chromatiales 135613|Chromatiales L PFAM NUDIX hydrolase nudE - - ko:K08312 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_53309_2 1049564.TevJSym_ao00540 5.26e-93 276.0 COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1J5ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S hydrolase (HAD superfamily) yrfG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_938320_1 485913.Krac_1895 6.66e-15 78.2 COG0657@1|root,COG0657@2|Bacteria,2G6IC@200795|Chloroflexi 2|Bacteria I PFAM Alpha beta hydrolase fold-3 domain protein - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3,Abhydrolase_6 k59_578538_1 645991.Sgly_3225 3.72e-39 138.0 COG1586@1|root,COG1586@2|Bacteria,1TQ7S@1239|Firmicutes,2480M@186801|Clostridia,2613W@186807|Peptococcaceae 186801|Clostridia E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speD - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_578538_2 322710.Avin_46900 4.84e-56 188.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_87958_1 909663.KI867150_gene1310 3.11e-17 80.1 COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,42Y9C@68525|delta/epsilon subdivisions,2WUJJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria U AAA domain - - - - - - - - - - - - AAA_22 k59_87958_2 909663.KI867150_gene1309 1.13e-25 103.0 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,42VCD@68525|delta/epsilon subdivisions,2WRUC@28221|Deltaproteobacteria 28221|Deltaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_905225_1 1121405.dsmv_0889 9.21e-49 163.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NRE@68525|delta/epsilon subdivisions,2WM0E@28221|Deltaproteobacteria,2MJFH@213118|Desulfobacterales 28221|Deltaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_154487_1 1168034.FH5T_07180 1.97e-99 294.0 COG0363@1|root,COG0363@2|Bacteria,4NHF8@976|Bacteroidetes,2FN1D@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso k59_154487_2 1168034.FH5T_07175 1.63e-31 122.0 COG0363@1|root,COG0363@2|Bacteria,4NDUN@976|Bacteroidetes,2FM2W@200643|Bacteroidia 976|Bacteroidetes G glucosamine-6-phosphate deaminase nagB - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso,PIG-L k59_350722_1 261292.Nit79A3_0870 6.7e-64 206.0 COG3239@1|root,COG3239@2|Bacteria,1NQ26@1224|Proteobacteria,2WAE4@28216|Betaproteobacteria,3741P@32003|Nitrosomonadales 28216|Betaproteobacteria I PFAM Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_479759_1 998088.B565_0536 2.12e-80 243.0 COG1573@1|root,COG1573@2|Bacteria,1R9XV@1224|Proteobacteria,1S20R@1236|Gammaproteobacteria,1Y4AU@135624|Aeromonadales 135624|Aeromonadales L Uracil DNA glycosylase superfamily - - - - - - - - - - - - UDG k59_479759_2 613026.HRAG_00933 1.9e-28 112.0 COG2009@1|root,31HUY@2|Bacteria,1RJJH@1224|Proteobacteria,43B2J@68525|delta/epsilon subdivisions,2YT5B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase cytochrome B subunit frdC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_382165_1 247634.GPB2148_2008 6.52e-57 196.0 2DNHZ@1|root,32XM8@2|Bacteria,1QUVC@1224|Proteobacteria,1SBS8@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_971329_2 1168034.FH5T_07850 1.15e-80 252.0 COG2244@1|root,COG2244@2|Bacteria,4NDZ0@976|Bacteroidetes,2FKYU@200643|Bacteroidia 976|Bacteroidetes S Polysaccharide biosynthesis protein cap - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_447487_1 265072.Mfla_1839 4.76e-82 266.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KKPG@206350|Nitrosomonadales 206350|Nitrosomonadales E Domain of unknown function (DUF3488) - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_515260_1 631362.Thi970DRAFT_04374 4.29e-284 781.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1WW2C@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_515260_2 1049564.TevJSym_aq00470 1.24e-56 180.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1J60N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iJN746.PP_5412 ATP-synt_DE,ATP-synt_DE_N k59_515260_3 1049564.TevJSym_aq00480 6.14e-69 213.0 COG1047@1|root,COG1047@2|Bacteria,1RH9C@1224|Proteobacteria,1S63R@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_515260_4 1049564.TevJSym_aq00490 1.12e-186 535.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1J4PN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_4420,iYL1228.KPN_04135 Hexapep,Hexapep_2,NTP_transf_3 k59_515260_5 396588.Tgr7_3302 0.0 926.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales 135613|Chromatiales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_252073_1 1116375.VEJY3_20801 1.81e-40 149.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1XURY@135623|Vibrionales 135623|Vibrionales L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_88798_1 396588.Tgr7_3031 2.77e-42 149.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria F dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs dgt GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_88798_2 105559.Nwat_0351 7.82e-20 88.6 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_220365_1 1304885.AUEY01000082_gene2154 4.38e-128 386.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42NEV@68525|delta/epsilon subdivisions,2WJD0@28221|Deltaproteobacteria,2MHX6@213118|Desulfobacterales 28221|Deltaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_220366_1 1242969.ATCC51562_161 1.95e-17 79.7 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2YM7K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_220366_2 387092.NIS_1500 2.74e-58 182.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,42TMU@68525|delta/epsilon subdivisions,2YPEI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_351522_1 264198.Reut_A0129 5.52e-32 118.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,1KFMT@119060|Burkholderiaceae 28216|Betaproteobacteria O Thiol disulfide interchange protein dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA,Thioredoxin k59_351522_2 1198452.Jab_1c11320 3.57e-12 65.9 COG0300@1|root,COG0300@2|Bacteria,1PNDU@1224|Proteobacteria,2VIWD@28216|Betaproteobacteria,473ZX@75682|Oxalobacteraceae 28216|Betaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family wcbP - - - - - - - - - - - adh_short k59_54105_1 118173.KB235914_gene3204 4.48e-59 191.0 COG0500@1|root,COG2226@2|Bacteria,1G49C@1117|Cyanobacteria,1HF55@1150|Oscillatoriales 1117|Cyanobacteria Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_18305_1 1537917.JU82_04590 2.36e-125 363.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2YN5P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_283191_2 1004785.AMBLS11_10535 1.03e-31 125.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,463YW@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_382842_1 713587.THITH_13630 1.48e-70 221.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1S0RR@1236|Gammaproteobacteria,1X1N1@135613|Chromatiales 135613|Chromatiales F Deoxynucleoside kinase - - 2.7.1.74,2.7.1.76 ko:K15519 ko00230,ko00240,ko01100,map00230,map00240,map01100 - R00185,R01666,R02089 RC00002,RC00017 ko00000,ko00001,ko01000 - - - dNK k59_252100_1 313603.FB2170_07984 3.06e-92 298.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,4NF4F@976|Bacteroidetes,1HXEG@117743|Flavobacteriia 976|Bacteroidetes C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_645033_1 387093.SUN_2183 1.2e-65 223.0 COG0474@1|root,COG0475@1|root,COG0474@2|Bacteria,COG0475@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0474 Cation transport ATPase - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,Na_H_Exchanger k59_18317_1 331869.BAL199_24724 4.49e-60 197.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2TQUM@28211|Alphaproteobacteria,4BRCA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_906046_1 323261.Noc_1367 4.75e-97 305.0 COG1743@1|root,COG1743@2|Bacteria,1P7I6@1224|Proteobacteria,1RY2K@1236|Gammaproteobacteria,1WXME@135613|Chromatiales 135613|Chromatiales L DNA methylase - - - - - - - - - - - - HTH_31,N6_N4_Mtase k59_645035_1 3983.cassava4.1_023131m 1.43e-24 96.3 COG0839@1|root,2QQHR@2759|Eukaryota,37N23@33090|Viridiplantae,3GCEY@35493|Streptophyta,4JS5P@91835|fabids 35493|Streptophyta C Belongs to the complex I subunit 6 family ndhG GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0044237 1.6.5.3 ko:K05578 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_q3 k59_645035_2 59689.fgenesh1_pm.C_scaffold_9000098 6.68e-97 284.0 COG1143@1|root,KOG3256@2759|Eukaryota,37YQF@33090|Viridiplantae,3GCUY@35493|Streptophyta 35493|Streptophyta C NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient ndhI GO:0003674,GO:0003824,GO:0003959,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009987,GO:0015979,GO:0016020,GO:0016491,GO:0016651,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0055114 1.6.5.3 ko:K05580 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Fer4 k59_220381_1 1121904.ARBP01000031_gene560 4.69e-71 228.0 COG2755@1|root,COG2755@2|Bacteria,4NEG4@976|Bacteroidetes,47MCN@768503|Cytophagia 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_939003_1 335543.Sfum_2600 1.34e-36 137.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,2MSJJ@213462|Syntrophobacterales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_252110_1 1121035.AUCH01000004_gene429 6.65e-96 313.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_1004537_1 33035.JPJF01000024_gene3211 1.83e-32 124.0 COG1609@1|root,COG1609@2|Bacteria,1VT4I@1239|Firmicutes,24YJ2@186801|Clostridia 186801|Clostridia K Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_4 k59_775100_1 439235.Dalk_2636 1.31e-33 135.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MIVE@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,PAS_4,PAS_9,Response_reg,Sigma54_activat k59_547054_1 391624.OIHEL45_00502 6.09e-08 53.5 COG0642@1|root,COG3300@1|root,COG2205@2|Bacteria,COG3300@2|Bacteria,1NRP8@1224|Proteobacteria,2U0Y1@28211|Alphaproteobacteria 28211|Alphaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,MHYT,Response_reg k59_155352_1 76114.ebA883 1.9e-99 300.0 COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria,2KVXA@206389|Rhodocyclales 206389|Rhodocyclales S cytochrome d1 heme nirF - - ko:K19345 - - - - ko00000 - - - Cytochrom_D1 k59_18332_1 765912.Thimo_1361 3.21e-109 323.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales 135613|Chromatiales GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind k59_18332_2 765911.Thivi_3871 2.46e-20 88.6 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1WXHI@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_645060_1 323850.Shew_1427 7.99e-71 223.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,2Q9P6@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM inositol monophosphatase cysQ GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - iAPECO1_1312.APECO1_2172,iE2348C_1286.E2348C_4545,iEC042_1314.EC042_4695,iEC55989_1330.EC55989_4774,iECABU_c1320.ECABU_c47840,iECIAI1_1343.ECIAI1_4448,iECIAI39_1322.ECIAI39_4686,iECO103_1326.ECO103_5013,iECO111_1330.ECO111_5101,iECO26_1355.ECO26_5384,iECOK1_1307.ECOK1_4735,iECP_1309.ECP_4468,iECSE_1348.ECSE_4520,iECSF_1327.ECSF_4108,iECUMN_1333.ECUMN_4751,iECW_1372.ECW_m4578,iEKO11_1354.EKO11_4094,iEcE24377_1341.EcE24377A_4785,iEcHS_1320.EcHS_A4468,iEcSMS35_1347.EcSMS35_4694,iLF82_1304.LF82_0422,iNRG857_1313.NRG857_21455,iSBO_1134.SBO_4229,iSDY_1059.SDY_4385,iSSON_1240.SSON_4399,iSbBS512_1146.SbBS512_E4758,iUMN146_1321.UM146_21355,iUTI89_1310.UTI89_C4823,iWFL_1372.ECW_m4578,ic_1306.c5313 Inositol_P k59_612505_1 595593.JREV01000046_gene590 1.55e-86 268.0 COG0493@1|root,COG0493@2|Bacteria,2I57P@201174|Actinobacteria,1WAES@1268|Micrococcaceae 201174|Actinobacteria E NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - NAD_binding_8 k59_155359_1 445970.ALIPUT_01020 2.49e-23 92.4 COG0724@1|root,COG0724@2|Bacteria,4NT1J@976|Bacteroidetes,2G2C9@200643|Bacteroidia 976|Bacteroidetes S RNA recognition motif - - - - - - - - - - - - RRM_1 k59_645068_1 2340.JV46_11770 1.07e-92 284.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1J54P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_547072_1 1254432.SCE1572_13430 3.99e-35 140.0 COG1948@1|root,COG4880@2|Bacteria,1P2CI@1224|Proteobacteria,439DV@68525|delta/epsilon subdivisions,2X4NS@28221|Deltaproteobacteria,2YZBF@29|Myxococcales 28221|Deltaproteobacteria L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_155360_1 1396858.Q666_02675 2.32e-75 237.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,4651N@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0436 Aspartate tyrosine aromatic aminotransferase dapC - 2.6.1.17 ko:K14261,ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_283235_1 362418.IW19_14140 5.15e-44 149.0 COG2003@1|root,COG2003@2|Bacteria,4NRCM@976|Bacteroidetes,1I1KW@117743|Flavobacteriia,2NVKU@237|Flavobacterium 976|Bacteroidetes L DNA repair protein - - - ko:K03630 - - - - ko00000 - - - RadC k59_939025_1 929558.SMGD1_1562 2.07e-49 168.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2YMMY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_939025_2 929558.SMGD1_1563 5.54e-124 365.0 COG0460@1|root,COG2716@1|root,COG0460@2|Bacteria,COG2716@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2YMUK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_645070_1 768671.ThimaDRAFT_3828 1.39e-98 318.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WX9H@135613|Chromatiales 135613|Chromatiales C pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_415166_1 1341181.FLJC2902T_19890 9.37e-29 114.0 COG4874@1|root,COG4874@2|Bacteria,4NFG3@976|Bacteroidetes,1HX0R@117743|Flavobacteriia,2NT5N@237|Flavobacterium 976|Bacteroidetes S Amidinotransferase - - - - - - - - - - - - Amidinotransf k59_415166_2 983544.Lacal_0094 1.02e-06 48.5 COG0599@1|root,COG0599@2|Bacteria,4NNRB@976|Bacteroidetes,1I23Q@117743|Flavobacteriia 976|Bacteroidetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_1004562_1 1168034.FH5T_16930 4.25e-74 247.0 COG0755@1|root,COG0755@2|Bacteria,4NDY1@976|Bacteroidetes,2FKZ1@200643|Bacteroidia 976|Bacteroidetes O cytochrome c-type biogenesis protein CcsB ccsA - - - - - - - - - - - Cytochrom_C_asm,ResB k59_1004565_1 349124.Hhal_0604 2.96e-55 187.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1WWKF@135613|Chromatiales 135613|Chromatiales O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_579190_1 1165841.SULAR_09609 4.71e-37 131.0 COG1387@1|root,COG1387@2|Bacteria,1MX8T@1224|Proteobacteria,43BI2@68525|delta/epsilon subdivisions,2YT8M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E PHP domain - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP,PHP_C k59_579190_2 1165841.SULAR_09614 8.08e-41 145.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2YNCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_382911_1 1172190.M947_02025 9.5e-77 248.0 COG4773@1|root,COG4773@2|Bacteria,1QZ1U@1224|Proteobacteria,42PHE@68525|delta/epsilon subdivisions,2YN5J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD k59_422959_2 1149133.ppKF707_1011 4.84e-23 98.2 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,1S3TH@1236|Gammaproteobacteria,1YCYX@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Steryl acetyl hydrolase - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_130029_1 1121405.dsmv_3397 5.6e-38 133.0 2DNCT@1|root,32WU5@2|Bacteria,1RKZ5@1224|Proteobacteria,42T1G@68525|delta/epsilon subdivisions,2WPD4@28221|Deltaproteobacteria,2MPJX@213118|Desulfobacterales 28221|Deltaproteobacteria C Class III cytochrome C family - - - - - - - - - - - - Cytochrom_CIII k59_783450_1 509635.N824_22795 1.24e-28 116.0 28JIP@1|root,2Z82C@2|Bacteria,4NFN9@976|Bacteroidetes,1IS0A@117747|Sphingobacteriia 976|Bacteroidetes S S1/P1 Nuclease - - - - - - - - - - - - S1-P1_nuclease k59_324392_1 1049564.TevJSym_aq00270 9.7e-109 327.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1J5A3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_488020_1 572544.Ilyop_1878 3.69e-109 326.0 COG0697@1|root,COG0697@2|Bacteria,37B4T@32066|Fusobacteria 32066|Fusobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_748934_1 387093.SUN_0711 2.94e-18 83.6 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2YMTP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_748934_2 572480.Arnit_0834 7.02e-42 147.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,42M7C@68525|delta/epsilon subdivisions,2YTS2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_96900_2 1265505.ATUG01000002_gene1709 3.14e-52 172.0 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2WPGW@28221|Deltaproteobacteria,2MI56@213118|Desulfobacterales 28221|Deltaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_291470_1 933262.AXAM01000040_gene1233 1.28e-65 210.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MI3G@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1012185_1 1123247.AUIJ01000038_gene2919 1.8e-104 322.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TWBA@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Dehydrogenase E1 component - - 1.2.4.4 ko:K11381,ko:K21416 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,E1_dh,Transket_pyr,Transketolase_C k59_913730_1 272942.RCAP_rcc00131 6.21e-31 124.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,1FB46@1060|Rhodobacter 28211|Alphaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N k59_457409_1 1537917.JU82_10015 2.24e-55 187.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,42NU0@68525|delta/epsilon subdivisions,2YN8B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM HI0933 family protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_880745_1 159087.Daro_3955 1.33e-45 158.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,2VIY1@28216|Betaproteobacteria,2KXBH@206389|Rhodocyclales 206389|Rhodocyclales S Fic/DOC family N-terminal - - - - - - - - - - - - Fic,Fic_N k59_324419_1 1500893.JQNB01000001_gene2188 4.89e-56 197.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1X3WG@135614|Xanthomonadales 135614|Xanthomonadales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_359435_1 470145.BACCOP_00043 1.01e-19 94.0 COG1196@1|root,COG1196@2|Bacteria,4NJ5T@976|Bacteroidetes,2FNV3@200643|Bacteroidia,4AM6B@815|Bacteroidaceae 976|Bacteroidetes D Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF3584 k59_1012199_1 572544.Ilyop_0221 2.07e-80 251.0 COG1055@1|root,COG1055@2|Bacteria,378C3@32066|Fusobacteria 32066|Fusobacteria P Arsenical pump membrane protein - - - - - - - - - - - - CitMHS k59_488051_1 706587.Desti_5501 3.16e-170 491.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_588041_2 1537915.JU57_08815 4.83e-110 322.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,42NZV@68525|delta/epsilon subdivisions,2YN88@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter permease modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_457416_1 1168034.FH5T_12500 7.5e-66 228.0 COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,2FMRZ@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_588044_1 379066.GAU_2194 9.89e-36 132.0 COG0412@1|root,COG0412@2|Bacteria,1ZUKT@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q BAAT / Acyl-CoA thioester hydrolase C terminal - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_588044_2 1089549.AZUQ01000001_gene992 2.26e-31 114.0 COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4EYVT@85014|Glycomycetales 201174|Actinobacteria S Zincin-like metallopeptidase - - - - - - - - - - - - Zincin_1 k59_979424_1 519989.ECTPHS_05556 1.34e-21 99.8 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1WXRX@135613|Chromatiales 135613|Chromatiales D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA - - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_652831_1 102125.Xen7305DRAFT_00009510 4.48e-40 151.0 COG5361@1|root,COG5361@2|Bacteria,1G6ZF@1117|Cyanobacteria,3VKJ9@52604|Pleurocapsales 1117|Cyanobacteria S Neurotransmitter-gated ion-channel ligand binding domain - - - - - - - - - - - - Neur_chan_LBD k59_62396_1 519989.ECTPHS_10356 7.99e-09 54.7 COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1WYAI@135613|Chromatiales 135613|Chromatiales S PFAM Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_62396_2 631362.Thi970DRAFT_01076 1.19e-65 215.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_423016_1 709032.Sulku_2229 6.09e-108 328.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YNDA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_652844_1 768704.Desmer_3001 3.53e-18 90.9 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,263ZP@186807|Peptococcaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_324470_1 1232443.BAIA02000043_gene2283 5.25e-46 154.0 COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,26967@186813|unclassified Clostridiales 186801|Clostridia C Psort location Cytoplasmic, score cutS - 1.17.1.5,1.2.5.3 ko:K03518,ko:K20446 ko00760,ko01120,map00760,map01120 - R01720,R11168 RC00589,RC02800 ko00000,ko00001,ko01000 - - - Fer2,Fer2_2 k59_324470_2 1380394.JADL01000002_gene1456 1.81e-05 47.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TRFN@28211|Alphaproteobacteria,2JQAQ@204441|Rhodospirillales 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - 1.17.1.4 ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_748966_1 1123400.KB904802_gene3186 1.73e-124 385.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,45ZPA@72273|Thiotrichales 72273|Thiotrichales F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_812855_1 1408439.JHXW01000006_gene988 1.26e-43 155.0 COG1032@1|root,COG1032@2|Bacteria,378NN@32066|Fusobacteria 32066|Fusobacteria C Radical SAM N-terminal - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_260191_2 1129374.AJE_08737 3.77e-43 159.0 COG1609@1|root,COG1609@2|Bacteria,1MU1G@1224|Proteobacteria,1RMSP@1236|Gammaproteobacteria,465QA@72275|Alteromonadaceae 1236|Gammaproteobacteria K transcriptional - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_260191_3 1304284.L21TH_1291 2.26e-43 148.0 COG3448@1|root,COG3448@2|Bacteria 2|Bacteria T diguanylate cyclase activity - - - - - - - - - - - - HPP k59_423025_1 749222.Nitsa_0703 3.08e-73 233.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2YMQM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_488089_1 649747.HMPREF0083_03502 1.54e-61 202.0 COG2230@1|root,COG2230@2|Bacteria,1TSG4@1239|Firmicutes,4HDKI@91061|Bacilli,2721T@186822|Paenibacillaceae 91061|Bacilli M Mycolic acid cyclopropane synthetase cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_291540_1 1462527.CCDM010000002_gene1322 1.08e-21 95.5 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,23ITE@182709|Oceanobacillus 91061|Bacilli T Protein phosphatase 2C stp - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_913774_1 1121451.DESAM_21562 1.24e-38 145.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MU2@68525|delta/epsilon subdivisions,2WMYH@28221|Deltaproteobacteria,2MGXV@213115|Desulfovibrionales 28221|Deltaproteobacteria M TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - - - - - - - - - - OEP k59_620891_1 335543.Sfum_1184 2.21e-11 70.1 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PFB9@1224|Proteobacteria,437WC@68525|delta/epsilon subdivisions,2X35Z@28221|Deltaproteobacteria,2MS2F@213462|Syntrophobacterales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - - k59_812878_2 338963.Pcar_2380 7.71e-49 171.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,43SX6@69541|Desulfuromonadales 28221|Deltaproteobacteria L DEAD DEAH box helicase domain protein recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_783525_1 1336245.JAGO01000011_gene157 4.95e-24 103.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1XHBY@135619|Oceanospirillales 135619|Oceanospirillales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_783525_2 768671.ThimaDRAFT_2163 1.14e-36 127.0 COG0346@1|root,COG0346@2|Bacteria,1RGZ8@1224|Proteobacteria,1S66M@1236|Gammaproteobacteria,1WYT7@135613|Chromatiales 135613|Chromatiales E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K08234 - - - - ko00000 - - - Glyoxalase k59_718032_1 1231185.BAMP01000027_gene2637 8.35e-35 119.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,43H15@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3,1.6.99.3 ko:K00338,ko:K03941 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 - - Fer4 k59_718032_2 59538.XP_005973866.1 2.39e-34 124.0 COG0839@1|root,2S66Q@2759|Eukaryota,39R01@33154|Opisthokonta,3BWF9@33208|Metazoa,3DKGM@33213|Bilateria 2759|Eukaryota C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 nad6 - 1.6.5.3 ko:K03884 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - Oxidored_q3 k59_324517_1 1168034.FH5T_01840 3e-25 103.0 COG4856@1|root,COG4856@2|Bacteria,4NHJQ@976|Bacteroidetes,2FM3I@200643|Bacteroidia 976|Bacteroidetes S YbbR-like protein - - - - - - - - - - - - YbbR k59_324517_2 445970.ALIPUT_00239 4.82e-21 89.4 COG0237@1|root,COG0237@2|Bacteria,4NQKS@976|Bacteroidetes,2FSP8@200643|Bacteroidia,22UJM@171550|Rikenellaceae 976|Bacteroidetes H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_880805_1 396595.TK90_2396 1.43e-64 223.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_291584_1 272562.CA_C3373 8.23e-83 254.0 COG4677@1|root,COG4677@2|Bacteria,1UYI6@1239|Firmicutes,24B29@186801|Clostridia,36EGX@31979|Clostridiaceae 186801|Clostridia G Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pectinesterase k59_652902_1 1265313.HRUBRA_01492 6.74e-44 151.0 COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_620909_2 33035.JPJF01000088_gene5 5.93e-31 127.0 COG1609@1|root,COG1609@2|Bacteria,1UI1I@1239|Firmicutes,25EAN@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - - - - - - - - - - LacI,Peripla_BP_4 k59_588133_1 519989.ECTPHS_01149 2.19e-51 176.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales 135613|Chromatiales S PFAM Peptidoglycan-binding lysin domain - - - - - - - - - - - - LysM k59_588133_2 1279019.ARQK01000056_gene294 1.46e-78 238.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_1012268_1 1537917.JU82_04695 1.88e-120 352.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2YMWK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I malonyl coa-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_457488_1 1121405.dsmv_2188 5.21e-122 355.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2MI2X@213118|Desulfobacterales 28221|Deltaproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_423067_1 1123325.JHUV01000008_gene508 5.19e-93 302.0 COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,2G3NC@200783|Aquificae 200783|Aquificae I PFAM AMP-dependent synthetase and ligase fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,Acyltransferase,PP-binding k59_750688_1 1379698.RBG1_1C00001G1210 2.8e-20 93.6 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family nla19 - - ko:K02667,ko:K07713,ko:K07714,ko:K19641 ko02020,map02020 M00499,M00500,M00501,M00772 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_750688_2 944546.ABED_0358 1.35e-50 165.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42RJW@68525|delta/epsilon subdivisions,2YP85@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_27888_1 933262.AXAM01000033_gene1647 3.64e-78 246.0 COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MI7W@213118|Desulfobacterales 28221|Deltaproteobacteria C CO dehydrogenase acetyl-CoA synthase delta subunit - - 2.1.1.245 ko:K00197 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD,FeS k59_489384_1 1207058.L53_05560 1.83e-09 60.5 COG1396@1|root,COG2856@1|root,COG1396@2|Bacteria,COG2856@2|Bacteria,1QYI0@1224|Proteobacteria,2U6BF@28211|Alphaproteobacteria 28211|Alphaproteobacteria K IrrE N-terminal-like domain - - - ko:K18831 - - - - ko00000,ko02048,ko03000 - - - HTH_3,Peptidase_M78 k59_489384_2 1173020.Cha6605_6292 1.53e-26 103.0 2DW4I@1|root,32V0S@2|Bacteria,1G7NI@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_489384_3 743721.Psesu_0665 7.2e-07 52.4 COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,1RRHP@1236|Gammaproteobacteria,1X33S@135614|Xanthomonadales 135614|Xanthomonadales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_489392_1 1121405.dsmv_0406 1.05e-87 266.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2MIAE@213118|Desulfobacterales 28221|Deltaproteobacteria C May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins nifU - - ko:K04488,ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N k59_292965_1 876269.ARWA01000001_gene2557 1.51e-18 84.3 2ED3M@1|root,3370H@2|Bacteria,1NB6I@1224|Proteobacteria,2UE8V@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_292965_2 105559.Nwat_2225 4.88e-33 119.0 COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,1S70H@1236|Gammaproteobacteria,1WZ8W@135613|Chromatiales 135613|Chromatiales S PFAM Invasion gene expression up-regulator SirB - - - - - - - - - - - - SirB k59_489396_1 563040.Saut_2123 9.54e-136 392.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2YMD9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_750710_1 697282.Mettu_2015 1.89e-78 238.0 COG1791@1|root,COG1791@2|Bacteria,1RCZD@1224|Proteobacteria,1S42U@1236|Gammaproteobacteria,1XF09@135618|Methylococcales 135618|Methylococcales S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway mtnD - 1.13.11.53,1.13.11.54 ko:K08967 ko00270,ko01100,map00270,map01100 M00034 R07363,R07364 RC01866,RC02018,RC02118 ko00000,ko00001,ko00002,ko01000 - - - ARD k59_750710_2 243233.MCA0799 5e-34 123.0 COG0235@1|root,COG0235@2|Bacteria,1RE8T@1224|Proteobacteria,1S3UF@1236|Gammaproteobacteria,1XDKT@135618|Methylococcales 135618|Methylococcales G Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) mtnB - 4.2.1.109 ko:K08964 ko00270,ko01100,map00270,map01100 M00034 R07392 RC01939 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_489407_1 1397528.Q671_14065 2.3e-116 340.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1XIDG@135619|Oceanospirillales 135619|Oceanospirillales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_489409_1 1304885.AUEY01000037_gene2207 1.37e-09 59.3 COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria,2MIY1@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 k59_915193_1 326298.Suden_1687 3.86e-68 214.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,42NIA@68525|delta/epsilon subdivisions,2YR33@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HJ Belongs to the RimK family rimK - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_915193_2 765912.Thimo_1587 2.9e-12 69.3 COG4067@1|root,COG4067@2|Bacteria,1N0VV@1224|Proteobacteria,1SZUE@1236|Gammaproteobacteria,1X1GQ@135613|Chromatiales 135613|Chromatiales O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease k59_915193_3 326298.Suden_1688 8.84e-45 155.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,42M7C@68525|delta/epsilon subdivisions,2YTS2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_849376_1 572477.Alvin_0697 3.65e-62 194.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria,1WYAU@135613|Chromatiales 135613|Chromatiales O TIGRFAM Thioredoxin - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin k59_849376_2 1097668.BYI23_A008710 8.74e-12 64.7 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,2VS2S@28216|Betaproteobacteria,1KH4H@119060|Burkholderiaceae 28216|Betaproteobacteria F Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_489420_1 887929.HMP0721_2435 4.02e-39 148.0 COG0419@1|root,COG0419@2|Bacteria,1TT6R@1239|Firmicutes,248NV@186801|Clostridia 186801|Clostridia L ATPase involved in DNA repair - - - - - - - - - - - - AAA_23 k59_489427_1 1168034.FH5T_17210 1.55e-92 291.0 COG1629@1|root,COG4771@2|Bacteria,4PM07@976|Bacteroidetes,2FYI1@200643|Bacteroidia 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_750737_1 439235.Dalk_3076 2.42e-50 177.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2MHX2@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_424479_1 997884.HMPREF1068_03081 9.36e-25 100.0 COG5495@1|root,COG5495@2|Bacteria,4NI4M@976|Bacteroidetes,2FMCQ@200643|Bacteroidia,4AKID@815|Bacteroidaceae 976|Bacteroidetes S NADP oxidoreductase coenzyme F420-dependent - - - - - - - - - - - - DUF2520,F420_oxidored,Rossmann-like k59_424479_2 1168034.FH5T_14390 4.66e-48 157.0 COG1778@1|root,COG1778@2|Bacteria,4NMHD@976|Bacteroidetes,2FTGQ@200643|Bacteroidia 976|Bacteroidetes S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - HAD_2,Hydrolase_3 k59_690861_1 42565.FP66_12905 6.18e-64 203.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1XJCZ@135619|Oceanospirillales 135619|Oceanospirillales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_135653_1 573413.Spirs_4003 3.37e-58 199.0 COG0188@1|root,COG0188@2|Bacteria,2J5Y9@203691|Spirochaetes 203691|Spirochaetes L Belongs to the type II topoisomerase GyrA ParC subunit family parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_topoisoIV k59_527848_2 391615.ABSJ01000045_gene2076 3.92e-37 131.0 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria 1224|Proteobacteria S Belongs to the UPF0225 family ychJ - - ko:K09858 - - - - ko00000 - - - SEC-C k59_527848_3 572544.Ilyop_0373 1.34e-26 104.0 COG0564@1|root,COG0564@2|Bacteria,37A6R@32066|Fusobacteria 32066|Fusobacteria J Belongs to the pseudouridine synthase RluA family - - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_102871_1 1249627.D779_3216 1.91e-31 122.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,1RQYZ@1236|Gammaproteobacteria,1WX9D@135613|Chromatiales 135613|Chromatiales C eight transmembrane protein EpsH - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_102871_2 1165096.ARWF01000001_gene465 6.71e-31 119.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VH0H@28216|Betaproteobacteria,2KKVU@206350|Nitrosomonadales 28216|Betaproteobacteria M TIGRFAM Undecaprenyl-phosphate glucose phosphotransferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_592408_1 765910.MARPU_08895 6.59e-83 263.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales 135613|Chromatiales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_984960_1 1283300.ATXB01000001_gene253 6.96e-40 142.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1XEN4@135618|Methylococcales 135618|Methylococcales M Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_952380_1 1165841.SULAR_09669 1.73e-51 173.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2YMI9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_364059_1 944547.ABLL_0017 3.52e-114 336.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,42MY7@68525|delta/epsilon subdivisions,2YP09@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the NadC ModD family modD - - ko:K03813 - - - - ko00000,ko01000 - - - QRPTase_C,QRPTase_N k59_364060_1 439235.Dalk_3669 2.9e-82 254.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria,2MITB@213118|Desulfobacterales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_592412_1 1158182.KB905028_gene2514 3.39e-35 139.0 COG2203@1|root,COG3829@1|root,COG5002@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T5TE@1236|Gammaproteobacteria,1X08C@135613|Chromatiales 135613|Chromatiales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3 k59_723484_1 1122211.JMLW01000008_gene2084 0.000215 45.4 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1XJJ5@135619|Oceanospirillales 135619|Oceanospirillales I 1-acyl-sn-glycerol-3-phosphate acyltransferase plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_723484_2 472759.Nhal_0220 4.48e-79 240.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,1WY8W@135613|Chromatiales 135613|Chromatiales E D,D-heptose 1,7-bisphosphate phosphatase - - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like k59_723484_3 1049564.TevJSym_aq00120 2.31e-55 174.0 2F88A@1|root,340MG@2|Bacteria,1NXS1@1224|Proteobacteria,1SQ1P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphoribosyl-ATP pyrophosphohydrolase - - - - - - - - - - - - MazG k59_755847_1 977880.RALTA_A0757 1.48e-61 207.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VHQJ@28216|Betaproteobacteria,1K0CF@119060|Burkholderiaceae 28216|Betaproteobacteria C D-amino acid dehydrogenase dadA2 - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO,FAD_binding_2 k59_952386_1 228410.NE0717 4.04e-10 58.2 COG1278@1|root,COG3326@1|root,COG1278@2|Bacteria,COG3326@2|Bacteria,1N6YM@1224|Proteobacteria,2VQXP@28216|Betaproteobacteria 28216|Betaproteobacteria K DNA-binding - - - - - - - - - - - - CSD,DUF1294 k59_952386_3 557599.MKAN_01050 8.97e-26 99.0 2DQ16@1|root,334AZ@2|Bacteria,2IMJY@201174|Actinobacteria,23A9M@1762|Mycobacteriaceae 201174|Actinobacteria S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like k59_821740_1 1547437.LL06_09295 6.41e-91 281.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQNH@28211|Alphaproteobacteria,43HF0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region - - - - - - - - - - - - ABC_tran,oligo_HPY k59_854385_1 1121878.AUGL01000002_gene2320 4.27e-59 204.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_690874_1 709032.Sulku_0236 1.11e-84 260.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2YMQW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_626110_1 991905.SL003B_0988 1.01e-80 253.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2TSJV@28211|Alphaproteobacteria,4BSN9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Ribulose bisphosphate carboxylase large chain, catalytic domain cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_626110_2 991905.SL003B_0987 5.27e-60 187.0 COG4451@1|root,COG4451@2|Bacteria,1R9ZE@1224|Proteobacteria,2U7JJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C ribulose bisphosphate carboxylase, small cbbS - 4.1.1.39 ko:K01602 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_small k59_659276_1 457570.Nther_0044 2.58e-22 96.7 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia 186801|Clostridia L hydrolase, TatD family tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_364710_1 1049564.TevJSym_bh00210 6.69e-10 62.8 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1J4C5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_8 k59_364710_2 1500893.JQNB01000001_gene1954 4.89e-05 45.8 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,1S26J@1236|Gammaproteobacteria,1X6CY@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis signal transduction protein cheW1 - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_952876_1 1286632.P278_22520 4.88e-40 149.0 COG3525@1|root,COG3525@2|Bacteria,4NEQN@976|Bacteroidetes,1HWKP@117743|Flavobacteriia 976|Bacteroidetes G Domain of unknown function (DUF4838) - - - - - - - - - - - - DUF4838,F5_F8_type_C,Glyco_hydro_67N k59_789439_1 1163407.UU7_09060 2.19e-130 390.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1X3QV@135614|Xanthomonadales 135614|Xanthomonadales C NADH:flavin oxidoreductase / NADH oxidase family - - 1.5.8.1,1.5.8.2 ko:K00317 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R01588,R02511 RC00185,RC00556,RC00557,RC00732 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_887000_1 261292.Nit79A3_2626 0.000616 43.1 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria,37263@32003|Nitrosomonadales 28216|Betaproteobacteria N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_200961_1 452637.Oter_0894 1.48e-21 93.2 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae 414999|Opitutae E glutamate synthase - - 1.4.7.1 ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 - R00021,R10086 RC00006,RC00010 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_200961_2 329726.AM1_6355 2.68e-87 270.0 COG0493@1|root,COG0493@2|Bacteria,1G0SD@1117|Cyanobacteria 1117|Cyanobacteria C TIGRFAM glutamate synthases, NADH NADPH, small subunit gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iJN678.gltD Fer4_20,Pyr_redox_2 k59_37286_1 1500893.JQNB01000001_gene1404 1.69e-98 305.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1X3MV@135614|Xanthomonadales 135614|Xanthomonadales C dehydrogenase lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_887007_1 504472.Slin_3459 2.51e-101 315.0 COG4935@1|root,COG4935@2|Bacteria,4NH8G@976|Bacteroidetes,47MKM@768503|Cytophagia 976|Bacteroidetes O PFAM Spore coat protein CotH cotH - - - - - - - - - - - CHB_HEX_C_1,CotH,LTD,P_proprotein k59_887008_2 1288494.EBAPG3_17700 3.88e-53 173.0 COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,37370@32003|Nitrosomonadales 28216|Betaproteobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_70333_2 1168034.FH5T_05150 1.86e-33 124.0 COG0628@1|root,COG0628@2|Bacteria,4NFHZ@976|Bacteroidetes,2FN2B@200643|Bacteroidia 976|Bacteroidetes F Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - AI-2E_transport k59_495471_1 1165841.SULAR_06073 2.63e-80 251.0 COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,42RB0@68525|delta/epsilon subdivisions,2YNE9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Pfam Transposase IS66 - - - - - - - - - - - - Porin_O_P k59_952886_1 522772.Dacet_2971 1.56e-50 184.0 COG0438@1|root,COG0613@1|root,COG0438@2|Bacteria,COG0613@2|Bacteria,2GFA3@200930|Deferribacteres 200930|Deferribacteres M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_332290_1 56780.SYN_00797 4.95e-74 237.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2WJ1H@28221|Deltaproteobacteria,2MQCJ@213462|Syntrophobacterales 28221|Deltaproteobacteria J MiaB-like tRNA modifying enzyme mtaB - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_626115_1 1122173.AXVL01000047_gene32 0.0 936.0 COG0542@1|root,COG0542@2|Bacteria,3793D@32066|Fusobacteria 32066|Fusobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_626115_2 1123367.C666_10155 1.62e-11 71.2 COG0596@1|root,COG0596@2|Bacteria,1MVTG@1224|Proteobacteria,2WHBE@28216|Betaproteobacteria 28216|Betaproteobacteria S Alpha/beta hydrolase family - - - ko:K10623 ko00622,ko01120,ko01220,map00622,map01120,map01220 M00539 R05364 RC00753,RC01339 br01602,ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_234015_1 1249480.B649_05665 1.36e-104 308.0 COG3852@1|root,COG3852@2|Bacteria,1QAGK@1224|Proteobacteria,42RSW@68525|delta/epsilon subdivisions,2YPDC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - - k59_234015_2 709032.Sulku_0982 7.29e-75 241.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2YMMT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_364741_1 1168034.FH5T_15135 3.78e-58 193.0 COG2755@1|root,COG2755@2|Bacteria,4NGW6@976|Bacteroidetes,2FN21@200643|Bacteroidia 976|Bacteroidetes E COG NOG14456 non supervised orthologous group - - - - - - - - - - - - Lipase_GDSL,Lipase_GDSL_2,LysM k59_332309_1 1095767.CAHD01000197_gene524 1.54e-87 281.0 COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4F1NX@85016|Cellulomonadaceae 201174|Actinobacteria L SMART DNA gyrase topoisomerase IV subunit A gyrA2 - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_887030_1 767434.Fraau_0881 1.51e-127 394.0 COG1530@1|root,COG3266@1|root,COG1530@2|Bacteria,COG3266@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1X37S@135614|Xanthomonadales 135614|Xanthomonadales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_200981_1 1168034.FH5T_06780 5.06e-279 785.0 COG0058@1|root,COG0058@2|Bacteria,4NGR1@976|Bacteroidetes,2FNN5@200643|Bacteroidia 976|Bacteroidetes G alpha-glucan phosphorylase glgP - 2.4.1.1,2.4.1.11,2.4.1.8 ko:K00688,ko:K00691,ko:K16153 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R00292,R01555,R02111 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003 - GH65,GT3,GT35 - DUF3417,Glycogen_syn,Phosphorylase k59_1018441_2 373903.Hore_20450 9.34e-18 81.6 COG3833@1|root,COG3833@2|Bacteria,1TRB7@1239|Firmicutes,248A7@186801|Clostridia,3WAZ6@53433|Halanaerobiales 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K15772 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 k59_528560_1 926551.KB900704_gene810 0.000164 46.2 COG2141@1|root,COG2141@2|Bacteria,4NH2N@976|Bacteroidetes,1I0UY@117743|Flavobacteriia,1EQHW@1016|Capnocytophaga 976|Bacteroidetes C Luciferase-type oxidoreductase, BA3436 family - - - - - - - - - - - - Bac_luciferase k59_397406_1 1168034.FH5T_20980 3.76e-72 218.0 COG3304@1|root,COG3304@2|Bacteria,4NQSS@976|Bacteroidetes,2FTAX@200643|Bacteroidia 976|Bacteroidetes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - YccF k59_397406_2 1121904.ARBP01000011_gene1488 5.39e-22 92.8 COG2350@1|root,COG2350@2|Bacteria,4NNMS@976|Bacteroidetes,47RAX@768503|Cytophagia 976|Bacteroidetes S YCII-related domain - - - - - - - - - - - - YCII k59_397406_3 1168034.FH5T_16805 1.93e-71 219.0 COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia 976|Bacteroidetes O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_822417_1 879212.DespoDRAFT_00958 2.54e-50 163.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,42S2E@68525|delta/epsilon subdivisions,2WMT9@28221|Deltaproteobacteria,2MITJ@213118|Desulfobacterales 28221|Deltaproteobacteria F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_822417_2 879212.DespoDRAFT_00957 1.83e-30 111.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42R2A@68525|delta/epsilon subdivisions,2WMUK@28221|Deltaproteobacteria,2MJJX@213118|Desulfobacterales 28221|Deltaproteobacteria H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_495498_1 316067.Geob_3189 3.81e-31 127.0 COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,42TBM@68525|delta/epsilon subdivisions,2WP92@28221|Deltaproteobacteria,43V6A@69541|Desulfuromonadales 28221|Deltaproteobacteria S Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - - - - - - - - - - DUF2235 k59_561230_1 1122134.KB893650_gene782 5.83e-07 57.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1XHNC@135619|Oceanospirillales 135619|Oceanospirillales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_920783_1 592027.CLG_B1847 3.82e-70 230.0 COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,24978@186801|Clostridia,36EJM@31979|Clostridiaceae 186801|Clostridia P Sulfate permease sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_920783_2 1319815.HMPREF0202_02933 3.48e-46 153.0 COG2824@1|root,COG2824@2|Bacteria 2|Bacteria P Alkylphosphonate utilization operon protein PhnA phnA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k59_920783_3 469618.FVAG_00896 0.0 931.0 COG0480@1|root,COG0480@2|Bacteria,3787D@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score 9.97 - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_920783_4 572544.Ilyop_1399 2.94e-180 511.0 COG0119@1|root,COG0119@2|Bacteria,3799V@32066|Fusobacteria 2|Bacteria H Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) nifV1 - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_920783_5 1262449.CP6013_0234 8.4e-95 290.0 COG2849@1|root,COG2849@2|Bacteria,1V5HE@1239|Firmicutes,24AYV@186801|Clostridia,36FJG@31979|Clostridiaceae 186801|Clostridia S repeat protein - - - - - - - - - - - - - k59_920783_6 572544.Ilyop_1401 1.9e-63 194.0 COG3411@1|root,COG3411@2|Bacteria 2|Bacteria C Ferredoxin fdx4 - - - - - - - - - - - 2Fe-2S_thioredx k59_920783_7 572544.Ilyop_1402 3.54e-246 683.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein nifB - - ko:K02585,ko:K02592 - - - - ko00000 - - - Nitro_FeMo-Co,Oxidored_nitro,Radical_SAM k59_920783_8 926561.KB900617_gene1449 1.6e-36 125.0 COG1433@1|root,COG1433@2|Bacteria 2|Bacteria S nitrogen fixation VPA0323 - - - - - - - - - - - Nitro_FeMo-Co k59_920783_9 572544.Ilyop_1404 8.33e-276 761.0 COG2710@1|root,COG2710@2|Bacteria 2|Bacteria C Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein nifB2 - - ko:K02585,ko:K02592 - - - - ko00000 - - - Nitro_FeMo-Co,Oxidored_nitro,Radical_SAM k59_920783_10 572544.Ilyop_1405 2.48e-280 773.0 COG2710@1|root,COG2710@2|Bacteria,37B8B@32066|Fusobacteria 32066|Fusobacteria C Nitrogenase component 1 type Oxidoreductase - - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_920783_11 572544.Ilyop_1406 9.92e-279 768.0 COG2710@1|root,COG2710@2|Bacteria 2|Bacteria C Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein nifK - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_920783_12 572544.Ilyop_1407 0.0 905.0 COG2710@1|root,COG2710@2|Bacteria 2|Bacteria C Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS02415 Oxidored_nitro k59_920783_13 572544.Ilyop_1408 2.75e-15 70.5 COG0347@1|root,COG0347@2|Bacteria 2|Bacteria K Belongs to the P(II) protein family - - - ko:K02589,ko:K02590,ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_952904_1 865861.AZSU01000001_gene72 2.5e-170 491.0 COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,36F3G@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase - - - ko:K07137 - - - - ko00000 - - - FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4 k59_952904_3 1123288.SOV_1c09360 2.01e-14 72.8 COG4968@1|root,COG4968@2|Bacteria,1VD7G@1239|Firmicutes,4H9IM@909932|Negativicutes 909932|Negativicutes NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl k59_332322_1 1249627.D779_2923 9.35e-101 298.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_234038_1 1265505.ATUG01000003_gene119 2e-93 281.0 COG3359@1|root,COG3359@2|Bacteria,1R6A2@1224|Proteobacteria,42MVN@68525|delta/epsilon subdivisions,2WK0C@28221|Deltaproteobacteria,2MJ33@213118|Desulfobacterales 28221|Deltaproteobacteria L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 k59_200998_1 269796.Rru_A2351 4.59e-29 120.0 COG2227@1|root,COG4122@1|root,COG2227@2|Bacteria,COG4122@2|Bacteria,1REAP@1224|Proteobacteria,2UH56@28211|Alphaproteobacteria,2JU84@204441|Rhodospirillales 204441|Rhodospirillales H Macrocin-O-methyltransferase (TylF) - - - ko:K05303 - - - - ko00000,ko01000 - - - TylF k59_561243_1 1408473.JHXO01000010_gene3560 2.65e-60 191.0 COG1137@1|root,COG1137@2|Bacteria,4NDUG@976|Bacteroidetes,2FKZE@200643|Bacteroidia 976|Bacteroidetes S ABC transporter, ATP-binding protein lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_3457_1 96561.Dole_1112 3.88e-07 53.1 COG0388@1|root,COG0388@2|Bacteria,1RIQI@1224|Proteobacteria,42T6J@68525|delta/epsilon subdivisions,2WPVY@28221|Deltaproteobacteria,2MN0C@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - CN_hydrolase k59_3457_2 469618.FVAG_02870 1e-63 204.0 COG1211@1|root,COG1211@2|Bacteria,379Y6@32066|Fusobacteria 32066|Fusobacteria I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_169211_1 1168034.FH5T_18915 2.11e-26 101.0 COG1476@1|root,COG1476@2|Bacteria 2|Bacteria K sequence-specific DNA binding espR GO:0002791,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0032991,GO:0032993,GO:0042802,GO:0043207,GO:0043565,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051171,GO:0051223,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070201,GO:0071944,GO:0075136,GO:0080090,GO:0090087,GO:0097159,GO:1901363,GO:1903506,GO:1903530,GO:2000112,GO:2001141 - ko:K03088,ko:K07110 - - - - ko00000,ko03000,ko03021 - - - HTH_3,HTH_31 k59_429522_1 1380394.JADL01000012_gene1024 4.38e-26 105.0 COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2JPCP@204441|Rhodospirillales 204441|Rhodospirillales Q homogentisate 1,2-dioxygenase - - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_429522_2 1123253.AUBD01000009_gene2221 3.11e-90 275.0 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,1RNYV@1236|Gammaproteobacteria,1X4ZT@135614|Xanthomonadales 135614|Xanthomonadales Q 2-keto-4-pentenoate hydratase uptA - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_332332_1 1463917.JODC01000007_gene7393 8.63e-75 233.0 COG0121@1|root,COG0121@2|Bacteria,2GXCD@201174|Actinobacteria 201174|Actinobacteria S Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine - - - - - - - - - - - - GATase_4,GATase_6 k59_364772_1 572480.Arnit_3091 2.35e-256 713.0 COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,42N3C@68525|delta/epsilon subdivisions,2YNS9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysN - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - GTP_EFTU,GTP_EFTU_D3 k59_364772_2 944547.ABLL_2806 7.75e-119 345.0 COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,42NYE@68525|delta/epsilon subdivisions,2YN2H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase cysD - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_756394_1 387093.SUN_0638 5.81e-92 283.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2YMMM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_985563_1 1408428.JNJP01000082_gene1798 1.3e-14 89.0 COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42Y8I@68525|delta/epsilon subdivisions,2WU5W@28221|Deltaproteobacteria,2M9F2@213115|Desulfovibrionales 28221|Deltaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HemolysinCabind k59_761204_2 1335757.SPICUR_07935 2.95e-25 97.4 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1WZ25@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_761204_3 314278.NB231_15888 1.95e-29 116.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_696427_1 187272.Mlg_0966 9.57e-57 183.0 COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,1T0KA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S O-Methyltransferase mdmC - - - - - - - - - - - Methyltransf_3 k59_566273_1 314278.NB231_08315 4.91e-109 319.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_728635_1 1144343.PMI41_00010 2.56e-173 488.0 COG1082@1|root,COG1082@2|Bacteria,1NFRG@1224|Proteobacteria,2U16J@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Sugar phosphate isomerases epimerases iolH - - ko:K06605 - - - - ko00000 - - - AP_endonuc_2 k59_728635_2 399741.Spro_2054 2.41e-116 344.0 COG1082@1|root,COG1082@2|Bacteria,1R5PQ@1224|Proteobacteria,1RPVT@1236|Gammaproteobacteria,3ZZVQ@613|Serratia 1236|Gammaproteobacteria G Xylose isomerase-like TIM barrel - - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_728635_3 1410624.JNKK01000032_gene42 1.5e-102 309.0 COG0673@1|root,COG0673@2|Bacteria,1UZEK@1239|Firmicutes,24AR9@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_827236_1 1168034.FH5T_00110 3.64e-38 129.0 2DQW9@1|root,3391K@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_827236_2 1168034.FH5T_00105 5.1e-69 214.0 COG0224@1|root,COG0224@2|Bacteria,4NM5H@976|Bacteroidetes,2FNPU@200643|Bacteroidia 976|Bacteroidetes C WbqC-like protein - - - - - - - - - - - - WbqC k59_728636_1 1168034.FH5T_18985 1.46e-89 284.0 COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,2FNBG@200643|Bacteroidia 976|Bacteroidetes M transglycosylase ponA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_892490_1 1249480.B649_09805 5.17e-80 251.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2YMVE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G phosphomannomutase glmM_1 - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_892490_2 387092.NIS_1427 6.78e-20 88.2 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,42ND2@68525|delta/epsilon subdivisions,2YMQ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_2 k59_792629_1 768671.ThimaDRAFT_0808 8.34e-94 287.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1WXN7@135613|Chromatiales 135613|Chromatiales P Chromate transporter - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_792629_2 1234595.C725_2497 1.6e-06 49.7 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,4BPW2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V ABC transporter transmembrane region msbA2 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_598840_1 1151292.QEW_2571 0.000483 42.7 COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,25QHE@186804|Peptostreptococcaceae 186801|Clostridia H Probable molybdopterin binding domain moeA2 - - - - - - - - - - - MoCF_biosynth k59_598840_2 1168034.FH5T_04250 2.15e-54 190.0 COG4775@1|root,COG4775@2|Bacteria,4NE80@976|Bacteroidetes,2FM1J@200643|Bacteroidia 976|Bacteroidetes M Outer membrane protein, OMP85 family - - - - - - - - - - - - Bac_surface_Ag,POTRA k59_270690_1 545264.KB898757_gene2444 2.1e-48 162.0 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1WY08@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_270690_2 1415780.JPOG01000001_gene1970 8.98e-77 235.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1X5XM@135614|Xanthomonadales 135614|Xanthomonadales C Rnf-Nqr subunit, membrane protein - - - - - - - - - - - - Rnf-Nqr k59_270690_3 572477.Alvin_1201 2.25e-06 48.1 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_303370_1 1144275.COCOR_01492 5.18e-107 329.0 COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,1R5MU@1224|Proteobacteria,42UIQ@68525|delta/epsilon subdivisions,2WQAN@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - - k59_501285_1 234267.Acid_7897 2.55e-26 113.0 COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria 57723|Acidobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - - k59_238923_1 385682.AFSL01000069_gene1456 1.42e-14 72.4 COG1309@1|root,COG1309@2|Bacteria,4NIBT@976|Bacteroidetes,2FU2E@200643|Bacteroidia,3XKI9@558415|Marinilabiliaceae 976|Bacteroidetes K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_238923_2 1168034.FH5T_02820 3.84e-47 163.0 COG1538@1|root,COG1538@2|Bacteria,4NFSW@976|Bacteroidetes,2FNYU@200643|Bacteroidia 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_566285_1 1165841.SULAR_01558 2.3e-94 285.0 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2YTP5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF21 - - - - - - - - - - - - CBS,DUF21 k59_270695_2 519989.ECTPHS_06512 1.89e-51 172.0 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,1X2NE@135613|Chromatiales 135613|Chromatiales S mRNA catabolic process - - - - - - - - - - - - - k59_598848_1 414684.RC1_3377 3.38e-58 197.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,2TUE5@28211|Alphaproteobacteria,2JPSJ@204441|Rhodospirillales 204441|Rhodospirillales S Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_664621_2 58344.JOEL01000001_gene389 5.71e-15 76.6 COG0664@1|root,COG0664@2|Bacteria,2GQ2Y@201174|Actinobacteria 201174|Actinobacteria K Crp-like helix-turn-helix domain - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_957692_1 381764.Fnod_0305 2.05e-37 135.0 COG1085@1|root,COG1085@2|Bacteria,2GCAX@200918|Thermotogae 200918|Thermotogae C galactose-1-phosphate uridylyltransferase - - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0896 GalP_UDP_tr_C,GalP_UDP_transf k59_957692_2 1278306.KB906908_gene647 4.12e-62 199.0 COG0009@1|root,COG0009@2|Bacteria,378B4@32066|Fusobacteria 32066|Fusobacteria J Belongs to the SUA5 family - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_957692_3 1216362.B437_04056 1.45e-33 122.0 28PNV@1|root,2ZCBC@2|Bacteria,37A2H@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_174137_1 1408164.MOLA814_01053 3.07e-14 69.3 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,1KQW6@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P ApaG domain apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_728650_1 709032.Sulku_2299 3.52e-67 214.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2YMMY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_501291_1 1265490.JHVY01000008_gene3976 2.26e-102 303.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Utp--glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_664625_1 749222.Nitsa_1758 5.82e-119 350.0 COG5557@1|root,COG5557@2|Bacteria,1R54P@1224|Proteobacteria,42N9S@68525|delta/epsilon subdivisions,2YN90@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Polysulphide reductase NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_141966_1 350688.Clos_0935 1.44e-42 151.0 COG0668@1|root,COG0668@2|Bacteria,1TSHU@1239|Firmicutes,249AB@186801|Clostridia,36GMB@31979|Clostridiaceae 186801|Clostridia M Mechanosensitive ion channel - - - ko:K16053 - - - - ko00000,ko02000 1.A.23.4.5 - - MS_channel k59_141966_2 1117108.PAALTS15_06309 7.21e-05 45.4 COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4HAIC@91061|Bacilli,26RUX@186822|Paenibacillaceae 91061|Bacilli P Arsenical pump membrane protein arsB_2 - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - CitMHS k59_566299_1 1121104.AQXH01000008_gene2392 2.82e-13 74.7 COG2866@1|root,COG2866@2|Bacteria,4NIJ0@976|Bacteroidetes 976|Bacteroidetes E Zn_pept - - - - - - - - - - - - Peptidase_M14 k59_402107_2 929558.SMGD1_0790 4.87e-67 207.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,42T4D@68525|delta/epsilon subdivisions,2YPHE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Low molecular weight phosphotyrosine protein phosphatase - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_926067_1 710111.FraQA3DRAFT_6356 2.03e-22 100.0 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4ERC1@85013|Frankiales 201174|Actinobacteria L tyrosine recombinase xerD GO:0008150,GO:0040007 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_434289_1 697282.Mettu_0883 1.95e-41 149.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1XDWN@135618|Methylococcales 135618|Methylococcales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_434289_2 1123279.ATUS01000001_gene1385 4.01e-54 174.0 COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,1J5TG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_174151_1 395961.Cyan7425_1960 2.32e-81 255.0 COG0297@1|root,COG0297@2|Bacteria,1G1YU@1117|Cyanobacteria,3KG2S@43988|Cyanothece 1117|Cyanobacteria F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA2 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_859477_1 1537917.JU82_04810 6.79e-157 452.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2YMS3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_206645_1 1168034.FH5T_09375 9.21e-19 88.6 COG4372@1|root,COG4372@2|Bacteria,4NJGZ@976|Bacteroidetes,2G2H0@200643|Bacteroidia 976|Bacteroidetes S Transposase - - - - - - - - - - - - - k59_468100_1 203120.LEUM_1013 8.1e-10 66.2 COG1401@1|root,COG3440@1|root,COG1401@2|Bacteria,COG3440@2|Bacteria,1V6W0@1239|Firmicutes,4HJKE@91061|Bacilli,4AY4T@81850|Leuconostocaceae 91061|Bacilli V Domain of unknown function (DUF3883) - - - - - - - - - - - - DUF3578,DUF3883 k59_468100_2 572480.Arnit_2984 2.87e-155 442.0 arCOG06575@1|root,2Z7V5@2|Bacteria,1NRMQ@1224|Proteobacteria,42M4D@68525|delta/epsilon subdivisions,2YMPI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Recognizes the double-stranded unmethylated sequence GATC and cleaves before G-1 - - 3.1.21.4 ko:K01155 - - - - ko00000,ko01000,ko02048 - - - DpnII k59_6475_1 880072.Desac_2637 3.48e-48 172.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MQCA@213462|Syntrophobacterales 28221|Deltaproteobacteria T Signal transduction histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like k59_238948_1 933262.AXAM01000023_gene648 8.36e-06 49.3 COG0860@1|root,COG0860@2|Bacteria,1N7CI@1224|Proteobacteria,42VXD@68525|delta/epsilon subdivisions,2WRP9@28221|Deltaproteobacteria,2MKU6@213118|Desulfobacterales 28221|Deltaproteobacteria M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_859482_1 55601.VANGNB10_cI0483 6.19e-96 291.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XT11@135623|Vibrionales 135623|Vibrionales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdA GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045250,GO:0045254,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_206649_1 1430440.MGMSRv2_1394 1.43e-28 109.0 COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,2U81N@28211|Alphaproteobacteria,2JT8H@204441|Rhodospirillales 204441|Rhodospirillales K COG1522 Transcriptional regulators - - - - - - - - - - - - HTH_AsnC-type k59_991215_1 1266908.AQPB01000053_gene554 3.37e-83 269.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1WWFC@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_534065_1 2340.JV46_06090 8.14e-23 95.1 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,1J5V7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Peptidase family U32 yhbV - - - - - - - - - - - Peptidase_U32 k59_534065_2 2340.JV46_06100 4.62e-88 268.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RP6X@1236|Gammaproteobacteria,1J5GC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Peptidase family U32 yhbU - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_468104_1 177437.HRM2_06560 8.44e-59 187.0 2DMB9@1|root,32G5X@2|Bacteria,1RK8Z@1224|Proteobacteria,42TZI@68525|delta/epsilon subdivisions,2WR6A@28221|Deltaproteobacteria,2MKEN@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_534070_1 1496688.ER33_02795 5.57e-100 298.0 COG2326@1|root,COG2326@2|Bacteria,1G159@1117|Cyanobacteria,22TKN@167375|Cyanobium 1117|Cyanobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_338148_1 287.DR97_3564 7.23e-42 162.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1YEAB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0050896,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264 - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iG2583_1286.G2583_0058 OstA,OstA_C k59_270716_1 521097.Coch_1948 4.29e-10 70.9 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,4NEHR@976|Bacteroidetes,1HYJU@117743|Flavobacteriia,1ERT1@1016|Capnocytophaga 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Eco57I,N6_Mtase,TaqI_C k59_206657_1 1168034.FH5T_03590 6.58e-69 229.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolase family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_303404_1 1307436.PBF_16224 2.55e-44 170.0 COG4585@1|root,COG5001@1|root,COG4585@2|Bacteria,COG5001@2|Bacteria,1UI7N@1239|Firmicutes,4ISN0@91061|Bacilli,1ZS9J@1386|Bacillus 91061|Bacilli T diguanylate cyclase - - - - - - - - - - - - GGDEF,MHYT,PAS,PAS_4,PAS_9 k59_501321_1 309801.trd_0623 2.71e-119 374.0 COG1185@1|root,COG1185@2|Bacteria,2G5TS@200795|Chloroflexi,27XQS@189775|Thermomicrobia 189775|Thermomicrobia J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_304165_2 765911.Thivi_3179 1.52e-09 57.8 COG1141@1|root,COG2878@1|root,COG1141@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales 135613|Chromatiales C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_109552_1 314278.NB231_15368 1.84e-65 216.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1S48Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 k59_370953_1 983545.Glaag_0081 1.57e-81 253.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,4642P@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG1194 A G-specific DNA glycosylase mutY GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_76716_1 1196323.ALKF01000161_gene775 1.21e-19 87.0 COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,4H9ZU@91061|Bacilli,26V4A@186822|Paenibacillaceae 91061|Bacilli G Fructose-bisphosphate aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_958542_1 1172190.M947_00815 1.26e-12 66.2 COG0802@1|root,COG0802@2|Bacteria,1Q97W@1224|Proteobacteria,42TIG@68525|delta/epsilon subdivisions,2YPKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ATPase or kinase tsaE - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_958542_2 243232.MJ_0234 4.1e-20 89.4 COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,23QA4@183939|Methanococci 183939|Methanococci E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_142878_1 1249627.D779_3945 7.2e-75 239.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1WWCN@135613|Chromatiales 135613|Chromatiales S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - - - - - - - - - - Peptidase_M48,TPR_19 k59_109555_1 323261.Noc_2266 8.03e-10 62.8 2DQ0C@1|root,33473@2|Bacteria,1NAM4@1224|Proteobacteria,1SCY6@1236|Gammaproteobacteria,1X1YC@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_109555_2 1304275.C41B8_11513 6.28e-13 75.9 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Protein involved in outer membrane biogenesis asmA - - ko:K07289 - - - - ko00000 - - - AsmA k59_893424_1 469381.Dpep_2022 4.35e-29 122.0 COG3383@1|root,COG3383@2|Bacteria,3TAAU@508458|Synergistetes 508458|Synergistetes C -binding domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3 k59_502246_1 690597.JH730931_gene3443 8.98e-64 211.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1YMB5@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsA GO:0003674,GO:0003824,GO:0008808,GO:0016740,GO:0016772,GO:0016780,GO:0030572 - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_926941_1 1168034.FH5T_10755 2.34e-114 357.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,4NE1X@976|Bacteroidetes,2FMPX@200643|Bacteroidia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_992077_1 869213.JCM21142_73019 1.49e-68 219.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - CHU_C,HYR,SLH,VCBS k59_534978_1 1163617.SCD_n02218 5.29e-71 223.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_729219_1 1283284.AZUK01000001_gene1836 8.23e-98 312.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1Y479@135624|Aeromonadales 135624|Aeromonadales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_207599_1 944560.HMPREF9058_2286 1.77e-35 130.0 COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4D436@85005|Actinomycetales 201174|Actinobacteria C Oxidoreductase, aldo keto reductase family protein - - - - - - - - - - - - Aldo_ket_red k59_207599_2 446468.Ndas_4500 1.59e-08 55.1 COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4EHHK@85012|Streptosporangiales 201174|Actinobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_271489_1 323848.Nmul_A1668 3.65e-55 195.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,3743Q@32003|Nitrosomonadales 28216|Betaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_402956_1 1121033.AUCF01000005_gene5229 9.64e-104 315.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,2JUG5@204441|Rhodospirillales 204441|Rhodospirillales P Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_828136_1 1121921.KB898713_gene1702 9.29e-44 160.0 COG1629@1|root,COG1629@2|Bacteria,1MWTT@1224|Proteobacteria,1RRQ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_1023895_1 485915.Dret_0875 1.56e-79 248.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2M7R3@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD hmcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - NrfD k59_958572_1 446465.Bfae_22060 7.47e-08 56.6 COG2267@1|root,COG2267@2|Bacteria,2I64U@201174|Actinobacteria,4FBM5@85020|Dermabacteraceae 201174|Actinobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_76745_1 332101.JIBU02000018_gene2259 1.83e-09 58.2 COG1846@1|root,COG1846@2|Bacteria,1V3PS@1239|Firmicutes,24I6N@186801|Clostridia,36IX9@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k59_766860_1 886379.AEWI01000022_gene103 6.53e-18 90.1 COG1520@1|root,COG1520@2|Bacteria,4NHQ3@976|Bacteroidetes,2FQ6V@200643|Bacteroidia,3XJUS@558415|Marinilabiliaceae 976|Bacteroidetes S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - DUF3352 k59_669982_1 387093.SUN_1881 1.28e-98 292.0 2DBB6@1|root,2Z85M@2|Bacteria,1QMDX@1224|Proteobacteria,42QTF@68525|delta/epsilon subdivisions,2YP1H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_832327_1 1150621.SMUL_1712 3.41e-39 144.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YM96@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cmeF - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_113424_1 1499967.BAYZ01000016_gene6537 2.06e-93 282.0 COG1879@1|root,COG1879@2|Bacteria 2|Bacteria G ABC-type sugar transport system periplasmic component ytfQ - - ko:K02058,ko:K10439 ko02010,ko02030,map02010,map02030 M00212,M00221 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_604419_1 926556.Echvi_1699 1.16e-130 407.0 COG3250@1|root,COG3250@2|Bacteria,4NFE8@976|Bacteroidetes,47MPU@768503|Cytophagia 976|Bacteroidetes G glycoside hydrolase family 2 sugar binding - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_106,Glyco_hydro_2_N k59_669984_1 105559.Nwat_1140 6.2e-06 51.6 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales 135613|Chromatiales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1027988_1 1049564.TevJSym_ad00300 1.25e-72 233.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J90E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Proton-conducting membrane transporter - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1027988_2 1049564.TevJSym_ad00290 1.06e-30 122.0 COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1J980@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2309) - - - ko:K09822 - - - - ko00000 - - - DUF2309 k59_147250_1 216591.BCAS0318 4.57e-13 71.6 COG4977@1|root,COG4977@2|Bacteria,1N8W2@1224|Proteobacteria,2WGI3@28216|Betaproteobacteria,1K140@119060|Burkholderiaceae 28216|Betaproteobacteria K transcriptional regulator Arac family - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_147250_2 457415.HMPREF1006_01665 3.44e-21 94.4 COG3949@1|root,COG3949@2|Bacteria,3TC2Q@508458|Synergistetes 508458|Synergistetes S Membrane - - - - - - - - - - - - - k59_604427_1 1232410.KI421425_gene1553 1.17e-48 173.0 COG4932@1|root,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_832338_1 794903.OPIT5_28160 1.28e-38 147.0 COG0587@1|root,COG0587@2|Bacteria,46SG0@74201|Verrucomicrobia,3K7QJ@414999|Opitutae 414999|Opitutae L DNA polymerase alpha chain like domain - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_796217_1 204669.Acid345_0280 2.75e-63 218.0 COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,3Y7G5@57723|Acidobacteria 57723|Acidobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_701759_2 395961.Cyan7425_2205 1.67e-06 51.2 COG0642@1|root,COG4251@1|root,COG0642@2|Bacteria,COG4251@2|Bacteria,1GHC4@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - DUF3365,GAF,HATPase_c,HisKA,Hpt,PAS_2,PAS_3,PAS_9,PHY,Response_reg k59_80479_1 525368.HMPREF0591_4258 3.24e-09 63.5 COG1231@1|root,COG1231@2|Bacteria,2GK23@201174|Actinobacteria,237YW@1762|Mycobacteriaceae 201174|Actinobacteria E (mono)amine oxidase - - - - - - - - - - - - Amino_oxidase,cNMP_binding k59_472361_2 1121937.AUHJ01000021_gene1432 4.56e-156 446.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,46BKC@72275|Alteromonadaceae 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_343567_2 871963.Desdi_3018 6.05e-31 134.0 COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,2605U@186807|Peptococcaceae 186801|Clostridia U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_733271_1 1049564.TevJSym_ah00220 1.12e-35 124.0 COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 k59_733271_2 472759.Nhal_3577 1.05e-19 88.2 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_439381_1 1265505.ATUG01000002_gene2040 5.32e-102 317.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB-2 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_897772_1 631362.Thi970DRAFT_03566 4.99e-20 84.7 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1WYUJ@135613|Chromatiales 135613|Chromatiales S Tol-Pal system-associated acyl-CoA thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_897772_2 325777.GW15_0214295 3.82e-56 185.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1X2XF@135614|Xanthomonadales 135614|Xanthomonadales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_507154_1 379731.PST_4156 2.32e-173 516.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1YZRZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Oligopeptidase A prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_344125_2 384676.PSEEN1800 6.67e-14 65.9 COG4736@1|root,COG4736@2|Bacteria 2|Bacteria O Cbb3-type cytochrome oxidase ccoQ - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_344125_3 546274.EIKCOROL_00704 8.38e-72 221.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,2KQ51@206351|Neisseriales 206351|Neisseriales C subunit II ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_733935_1 469618.FVAG_00552 2.8e-52 172.0 COG2003@1|root,COG2003@2|Bacteria,379YZ@32066|Fusobacteria 32066|Fusobacteria E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_733935_2 572544.Ilyop_0516 9.34e-146 419.0 COG1774@1|root,COG1774@2|Bacteria,378EZ@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - PSP1 k59_733935_3 272563.CD630_35470 2.68e-61 199.0 COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,25QWN@186804|Peptostreptococcaceae 186801|Clostridia S Methyltransferase domain yfiC - 2.1.1.223 ko:K15460 - - - - ko00000,ko01000,ko03016 - - - MTS,Methyltransf_31 k59_733935_4 1443122.Z958_03180 8.62e-05 43.9 COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,36DSR@31979|Clostridiaceae 186801|Clostridia L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_275746_1 572544.Ilyop_1174 3.59e-10 58.2 COG3981@1|root,COG3981@2|Bacteria,37B20@32066|Fusobacteria 32066|Fusobacteria S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 k59_275746_2 1151116.Q7S_18615 5.67e-110 323.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,1RSP8@1236|Gammaproteobacteria 1236|Gammaproteobacteria T OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_275746_3 1121918.ARWE01000001_gene2845 1.26e-64 213.0 COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,42QVG@68525|delta/epsilon subdivisions,2WNKA@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_275746_4 1121324.CLIT_11c02640 1.25e-43 148.0 2C0FA@1|root,3466W@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_275746_5 1319815.HMPREF0202_00782 1.32e-164 473.0 COG1979@1|root,COG1979@2|Bacteria,3792X@32066|Fusobacteria 32066|Fusobacteria C Iron-containing alcohol dehydrogenase bdhA - - ko:K00100 ko00650,ko01120,map00650,map01120 - R03544,R03545 RC00087 ko00000,ko00001,ko01000 - - - Fe-ADH k59_275746_6 1122918.KB907247_gene4889 5.72e-14 71.2 COG0726@1|root,COG0726@2|Bacteria,1U0B6@1239|Firmicutes,4HE13@91061|Bacilli,26SJ5@186822|Paenibacillaceae 91061|Bacilli G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_931746_1 933262.AXAM01000039_gene1157 7.86e-52 181.0 COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,43BS1@68525|delta/epsilon subdivisions,2X72V@28221|Deltaproteobacteria,2MPJD@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA k59_10728_1 1395571.TMS3_0106080 2.59e-34 119.0 COG1734@1|root,COG1734@2|Bacteria,1MZIB@1224|Proteobacteria,1S8SP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T DnaK suppressor protein ybiI - - - - - - - - - - - zf-dskA_traR k59_440068_1 944547.ABLL_0563 3.39e-28 109.0 COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,42PCG@68525|delta/epsilon subdivisions,2YN6X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S metallophosphoesterase - - - ko:K09769 - - - - ko00000 - - - YmdB k59_440068_2 1249480.B649_02650 5.27e-75 231.0 COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,42QYA@68525|delta/epsilon subdivisions,2YP2S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L endonuclease III magIII - - ko:K07457 - - - - ko00000 - - - HhH-GPD k59_473081_1 340099.Teth39_0706 4.43e-48 161.0 COG2128@1|root,COG2128@2|Bacteria,1VAK9@1239|Firmicutes,24YCS@186801|Clostridia,42HY6@68295|Thermoanaerobacterales 186801|Clostridia C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_605085_1 1395571.TMS3_0104735 1.94e-29 118.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyltransferase,Aminotran_1_2,NAD_binding_4,PP-binding,Thioesterase k59_997064_1 1049564.TevJSym_az00150 7.19e-97 300.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1J4QW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_507774_1 283942.IL0168 1.59e-37 144.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria,2QH1J@267893|Idiomarinaceae 1236|Gammaproteobacteria P TonB dependent receptor oprC - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1028571_1 765910.MARPU_04600 4.57e-128 382.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_473100_1 1278306.KB906909_gene541 6.51e-27 104.0 COG1187@1|root,COG1187@2|Bacteria,3791T@32066|Fusobacteria 32066|Fusobacteria J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_473100_2 443144.GM21_4017 8.18e-53 177.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,42SH7@68525|delta/epsilon subdivisions,2WP40@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM PHP domain protein - - - ko:K02347,ko:K04477 - - - - ko00000,ko03400 - - - PHP k59_931767_1 768066.HELO_3917 1.14e-21 98.6 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XH8V@135619|Oceanospirillales 135619|Oceanospirillales S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_540000_1 1048339.KB913029_gene4863 5.13e-118 352.0 COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4ES3S@85013|Frankiales 201174|Actinobacteria D TIGRFAM Cell shape determining protein MreB Mrl mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_244535_1 572544.Ilyop_0880 1.04e-72 223.0 COG1658@1|root,COG1658@2|Bacteria,378UX@32066|Fusobacteria 32066|Fusobacteria J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step rnmV GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043822,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 3.1.26.8 ko:K05985 - - - - ko00000,ko01000 - - - DUF4093,Toprim,Toprim_4 k59_702406_1 572544.Ilyop_1711 5.95e-54 178.0 COG1161@1|root,COG1161@2|Bacteria,37846@32066|Fusobacteria 32066|Fusobacteria S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity ylqF - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 k59_702406_2 572544.Ilyop_1710 8.06e-148 421.0 COG0171@1|root,COG0171@2|Bacteria,378BE@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase k59_702406_3 1121428.DESHY_40220___1 1.78e-99 308.0 COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,260AI@186807|Peptococcaceae 186801|Clostridia H dihydropteroate synthase folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS03115 Pterin_bind k59_702406_4 1123274.KB899407_gene258 4.76e-33 120.0 29IC7@1|root,3059E@2|Bacteria,2JAQH@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - k59_702406_5 1382304.JNIL01000001_gene1510 3.34e-34 130.0 COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,4HCSI@91061|Bacilli 91061|Bacilli K Transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_702406_6 748449.Halha_2507 2.89e-124 361.0 COG3718@1|root,COG3718@2|Bacteria,1TR6M@1239|Firmicutes,2491W@186801|Clostridia 186801|Clostridia G Myo-inositol catabolism protein IolB iolB - 5.3.1.30 ko:K03337 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08503 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_702406_7 748449.Halha_2504 5.69e-175 492.0 COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,24AF7@186801|Clostridia 186801|Clostridia G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) iolE - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_702406_8 411490.ANACAC_00433 6.86e-32 122.0 COG0176@1|root,COG0176@2|Bacteria,1U9RA@1239|Firmicutes,24DCI@186801|Clostridia 186801|Clostridia H PFAM Transaldolase - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_931768_1 387093.SUN_1437 1.32e-117 357.0 COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,43B1H@68525|delta/epsilon subdivisions,2YT54@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC-type multidrug transport system ATPase and permease - - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_931768_2 1165841.SULAR_01430 2.53e-65 205.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,42NIR@68525|delta/epsilon subdivisions,2YNHV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E phosphoserine phosphatase serB - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD,Hydrolase k59_898500_1 714943.Mucpa_2410 5.93e-19 85.1 COG2207@1|root,COG2207@2|Bacteria,4NGS3@976|Bacteroidetes,1INPH@117747|Sphingobacteriia 976|Bacteroidetes K transcriptional regulator, AraC - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC k59_898500_2 1168034.FH5T_08615 6.23e-33 125.0 COG2610@1|root,COG2610@2|Bacteria,4NFBD@976|Bacteroidetes 976|Bacteroidetes EG Gluconate transporter - - - ko:K03299,ko:K06156 - - - - ko00000,ko02000 2.A.8,2.A.8.1.8 - - GntP_permease k59_114128_1 1137799.GZ78_16435 2.51e-26 106.0 COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria,1XQ2D@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF4143) - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_796953_1 1026882.MAMP_00477 2.2e-12 72.4 COG3210@1|root,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,1RNRK@1236|Gammaproteobacteria,46255@72273|Thiotrichales 72273|Thiotrichales U haemagglutination activity domain - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act k59_244536_1 204669.Acid345_0982 3.8e-130 391.0 COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria,2JHT1@204432|Acidobacteriia 204432|Acidobacteriia O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_114129_1 1094980.Mpsy_2239 1.68e-196 576.0 COG0610@1|root,arCOG00878@2157|Archaea,2XSZ2@28890|Euryarchaeota,2NAFZ@224756|Methanomicrobia 224756|Methanomicrobia V Type I restriction enzyme R protein N terminus (HSDR_N) - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - HSDR_N,ResIII k59_375607_1 469618.FVAG_01144 1.15e-65 217.0 COG1502@1|root,COG1502@2|Bacteria,3789J@32066|Fusobacteria 32066|Fusobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_796954_2 589865.DaAHT2_0188 1.33e-23 95.9 2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,42VK6@68525|delta/epsilon subdivisions,2WSUY@28221|Deltaproteobacteria,2MP5H@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_244537_2 596154.Alide2_3999 2.28e-08 55.1 COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,2VM4U@28216|Betaproteobacteria,4AHX4@80864|Comamonadaceae 28216|Betaproteobacteria S Phage tail sheath C-terminal domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_931776_1 491205.JARQ01000007_gene3059 1.95e-55 196.0 COG3299@1|root,COG3299@2|Bacteria,4NF69@976|Bacteroidetes,1HYP7@117743|Flavobacteriia,3ZTK3@59732|Chryseobacterium 976|Bacteroidetes S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_212913_1 238854.Q5GQD0_BPSYP 2.16e-09 65.9 4QC9M@10239|Viruses,4QXWJ@35237|dsDNA viruses no RNA stage,4QPID@28883|Caudovirales,4QI28@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_865279_1 1283300.ATXB01000001_gene1484 9.14e-50 174.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1XEAR@135618|Methylococcales 135618|Methylococcales H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_865279_2 1502770.JQMG01000001_gene2321 3.93e-41 146.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KM5R@206350|Nitrosomonadales 206350|Nitrosomonadales J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_733951_1 933262.AXAM01000009_gene1483 7.61e-105 311.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,42P1T@68525|delta/epsilon subdivisions,2WKZB@28221|Deltaproteobacteria,2MI0P@213118|Desulfobacterales 28221|Deltaproteobacteria F TIGRFAM deoxyguanosinetriphosphate triphosphohydrolase - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_10759_3 1537917.JU82_03080 1.11e-191 547.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_244542_1 1353276.JADR01000001_gene710 2.85e-122 365.0 COG2067@1|root,COG2067@2|Bacteria,4NG1B@976|Bacteroidetes,1HY7J@117743|Flavobacteriia 976|Bacteroidetes I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_898517_1 1541960.KQ78_01633 1.18e-31 123.0 COG0482@1|root,COG0482@2|Bacteria,3WSW0@544448|Tenericutes 544448|Tenericutes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 trmU - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_670647_1 754477.Q7C_1315 2.37e-13 72.0 COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,463VW@72273|Thiotrichales 72273|Thiotrichales S The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters bioH - 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_670647_2 1249627.D779_1617 7.62e-89 270.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_375618_1 1121405.dsmv_1727 5.34e-61 192.0 COG0461@1|root,COG0461@2|Bacteria,1PI8N@1224|Proteobacteria,42QSR@68525|delta/epsilon subdivisions,2WMT5@28221|Deltaproteobacteria,2MJH0@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_407897_1 1121459.AQXE01000002_gene1277 4.33e-26 107.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,42M9F@68525|delta/epsilon subdivisions,2WJNB@28221|Deltaproteobacteria,2M8DQ@213115|Desulfovibrionales 28221|Deltaproteobacteria G phosphoglucomutase phosphomannomutase alpha beta alpha domain I pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_407897_2 411469.EUBHAL_00923 3.35e-13 69.3 COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,248JE@186801|Clostridia,25VG1@186806|Eubacteriaceae 186801|Clostridia H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_706919_1 1121889.AUDM01000011_gene2839 1.78e-10 59.7 COG2827@1|root,COG2827@2|Bacteria,4NW73@976|Bacteroidetes,1I5Z9@117743|Flavobacteriia 976|Bacteroidetes L GIY-YIG catalytic domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_412368_1 929558.SMGD1_1543 1.33e-67 221.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,42KZC@68525|delta/epsilon subdivisions,2YM82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_412368_2 1355374.JARU01000006_gene1728 1.09e-08 54.3 COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42UAU@68525|delta/epsilon subdivisions,2YNG0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_544075_1 991905.SL003B_2894 1.44e-95 302.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,4BP8M@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Domain of unknown function (DUF3458_C) ARM repeats pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_738191_1 1278309.KB907100_gene1848 8.43e-123 389.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHII@135619|Oceanospirillales 135619|Oceanospirillales T Diguanylate cyclase phosphodiesterase with PAS PAC - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_9 k59_738191_2 511.JT27_14330 2.59e-05 45.4 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH41@28216|Betaproteobacteria,3T1YP@506|Alcaligenaceae 28216|Betaproteobacteria I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phbC2 - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_902979_1 713586.KB900536_gene3026 1.19e-70 215.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,1WYAR@135613|Chromatiales 135613|Chromatiales K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_902980_2 1121129.KB903367_gene2710 8.29e-08 56.6 COG3595@1|root,COG3595@2|Bacteria,4NGJ2@976|Bacteroidetes,2G1JM@200643|Bacteroidia,22ZBU@171551|Porphyromonadaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_348750_1 1385515.N791_13165 9.13e-63 200.0 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria,1X3FG@135614|Xanthomonadales 135614|Xanthomonadales F COG0209 Ribonucleotide reductase, alpha subunit - - - - - - - - - - - - - k59_544082_1 1453501.JELR01000001_gene2118 6.68e-84 261.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,4647G@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG1448 Aspartate tyrosine aromatic aminotransferase aspC - 2.6.1.1,2.6.1.57 ko:K00813,ko:K00832 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 M00024,M00025,M00034,M00040 R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_217558_2 1537917.JU82_09795 3.72e-213 604.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2YMCR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_380162_1 519989.ECTPHS_01979 7.46e-49 172.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1X2Q0@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_1032992_1 1168034.FH5T_07695 1.08e-88 280.0 COG3345@1|root,COG3345@2|Bacteria,4NHAT@976|Bacteroidetes,2FM30@200643|Bacteroidia 976|Bacteroidetes G Alpha-galactosidase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase k59_280231_1 1168034.FH5T_05500 1.09e-66 219.0 COG0642@1|root,COG2205@2|Bacteria,4NEFW@976|Bacteroidetes,2FPG5@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein rprX - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_280231_2 203275.BFO_1089 7.69e-32 117.0 COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,2FPNN@200643|Bacteroidia,22XY4@171551|Porphyromonadaceae 976|Bacteroidetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_118852_1 497321.C664_15158 1.04e-85 265.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2VJ7A@28216|Betaproteobacteria 28216|Betaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wbpO - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_380167_1 720555.BATR1942_15215 2.8e-57 187.0 COG4977@1|root,COG4977@2|Bacteria,1TXM2@1239|Firmicutes,4HCAA@91061|Bacilli,1ZGZJ@1386|Bacillus 91061|Bacilli K intracellular protease amidase - - - - - - - - - - - - DJ-1_PfpI k59_412377_1 926561.KB900623_gene1017 8.73e-14 76.3 COG1033@1|root,COG1033@2|Bacteria,1UVYF@1239|Firmicutes,25J6F@186801|Clostridia,3WBJS@53433|Halanaerobiales 186801|Clostridia S Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - MMPL k59_544087_1 1123257.AUFV01000009_gene2289 7.42e-71 225.0 COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,1RMAC@1236|Gammaproteobacteria,1X3PF@135614|Xanthomonadales 135614|Xanthomonadales S EamA-like transporter family - - - - - - - - - - - - EamA k59_837537_1 563040.Saut_1484 5.4e-07 50.4 COG0754@1|root,COG0754@2|Bacteria,1MW6V@1224|Proteobacteria,42N3V@68525|delta/epsilon subdivisions,2YMBJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutathionylspermidine synthase gss - - - - - - - - - - - GSP_synth k59_837537_2 1172190.M947_10480 8.91e-59 189.0 28WAS@1|root,2ZIB8@2|Bacteria,1NBB7@1224|Proteobacteria,42P2G@68525|delta/epsilon subdivisions,2YNQ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_772253_1 880072.Desac_0544 5.93e-93 303.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II por - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_801472_1 944547.ABLL_0167 3.05e-53 177.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2YMYB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_675315_1 713586.KB900536_gene2639 3.53e-81 255.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_576472_1 522306.CAP2UW1_4007 6.7e-34 133.0 COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria 1224|Proteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_184951_2 1227276.HMPREF9148_01794 1.45e-13 72.0 COG1309@1|root,COG1309@2|Bacteria,4NK27@976|Bacteroidetes 976|Bacteroidetes K Transcriptional regulator, TetR family - - - - - - - - - - - - TetR_N k59_675322_2 2340.JV46_09630 3.37e-18 84.7 COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,1RQGG@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto k59_706954_1 1236542.BALM01000001_gene214 6.47e-50 173.0 COG3104@1|root,COG3104@2|Bacteria,1P6K2@1224|Proteobacteria,1RZ5I@1236|Gammaproteobacteria,2Q8GE@267890|Shewanellaceae 1236|Gammaproteobacteria E PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 k59_118855_1 1167006.UWK_00110 4.39e-106 318.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2WIXR@28221|Deltaproteobacteria,2MIJ6@213118|Desulfobacterales 28221|Deltaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_544101_1 1537917.JU82_00095 1.7e-87 267.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2YMDC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_444710_1 404589.Anae109_0361 4.22e-39 137.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,42QT6@68525|delta/epsilon subdivisions,2WNC5@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1001578_2 519989.ECTPHS_08246 1.05e-64 209.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydratase - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_280257_1 1408310.JHUW01000006_gene1190 8.36e-26 111.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FWW6@200643|Bacteroidia 976|Bacteroidetes H TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_869764_1 1537917.JU82_07405 2.55e-27 100.0 COG3197@1|root,COG3197@2|Bacteria,1NEH5@1224|Proteobacteria,42VDQ@68525|delta/epsilon subdivisions,2YQ99@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Cytochrome oxidase maturation protein ccoS - - - - - - - - - - - FixS k59_869764_2 90813.JQMT01000001_gene559 8.69e-09 55.8 COG2863@1|root,COG2863@2|Bacteria 2|Bacteria C cytochrome cccB - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_738227_1 933262.AXAM01000019_gene1102 1.01e-99 300.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MIF1@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_837557_1 1168034.FH5T_13675 8.21e-156 442.0 COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,2FNXM@200643|Bacteroidia 976|Bacteroidetes S Von Willebrand factor type A domain batA - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA k59_152465_1 1123371.ATXH01000009_gene1095 2.89e-49 174.0 2DBKT@1|root,2Z9V9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_675333_1 765913.ThidrDRAFT_2816 6.93e-50 177.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales 135613|Chromatiales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_675333_2 1449357.JQLK01000001_gene1992 4.29e-29 119.0 COG1253@1|root,COG1253@2|Bacteria,1WI7Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S COGs COG1253 Hemolysins and related protein containing CBS domains - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_544120_1 1168034.FH5T_20555 2.94e-112 347.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,4NFTI@976|Bacteroidetes,2FNSJ@200643|Bacteroidia 976|Bacteroidetes C CoA binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_675339_1 877411.JMMA01000002_gene248 3.71e-07 50.4 COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,3WJWZ@541000|Ruminococcaceae 186801|Clostridia O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_772287_1 32049.SYNPCC7002_A2816 3.28e-22 97.8 COG0317@1|root,COG0317@2|Bacteria,1G0KC@1117|Cyanobacteria,1GZG8@1129|Synechococcus 1117|Cyanobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_477639_1 1353537.TP2_12945 6.59e-66 214.0 COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2TWCZ@28211|Alphaproteobacteria,2XMRA@285107|Thioclava 28211|Alphaproteobacteria CI Phosphate acetyl/butaryl transferase pta - 2.3.1.19,2.3.1.8 ko:K00625,ko:K00634 ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921,R01174 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas,PTA_PTB k59_936138_1 742821.HMPREF9464_00219 1.02e-20 92.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VHHB@28216|Betaproteobacteria,4PRNX@995019|Sutterellaceae 28216|Betaproteobacteria K Transcriptional regulatory protein, C terminal copR - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_348801_1 1089544.KB912942_gene7788 1.46e-80 260.0 COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria,4DZWK@85010|Pseudonocardiales 201174|Actinobacteria EH PFAM Thiamine pyrophosphate enzyme, N-terminal TPP binding domain ilvX GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0030312,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_412417_1 929558.SMGD1_2355 5.47e-26 111.0 COG2199@1|root,COG3706@2|Bacteria,1R1K2@1224|Proteobacteria,42YWW@68525|delta/epsilon subdivisions,2YR1I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Double sensory domain of two-component sensor kinase - - - - - - - - - - - - GGDEF,dCache_3 k59_903048_1 765912.Thimo_1578 5.68e-103 307.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1WWUS@135613|Chromatiales 135613|Chromatiales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_412421_1 1049564.TevJSym_ak00770 4.47e-68 216.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1J528@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Displays ATPase and GTPase activities rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_184998_1 631454.N177_1855 2.39e-64 215.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,1JPC9@119043|Rhodobiaceae 28211|Alphaproteobacteria G Carbohydrate phosphorylase glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_51263_1 153948.NAL212_0390 1.27e-44 150.0 COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,2VTAR@28216|Betaproteobacteria,374IE@32003|Nitrosomonadales 28216|Betaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_51263_2 387093.SUN_1382 7.11e-55 173.0 COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42U0X@68525|delta/epsilon subdivisions,2YPSD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 k59_51263_3 387093.SUN_1381 2.82e-79 237.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42RQI@68525|delta/epsilon subdivisions,2YT2S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Low molecular weight phosphotyrosine protein phosphatase - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_51263_4 1128427.KB904821_gene1136 3.46e-30 110.0 2CCSR@1|root,32RWC@2|Bacteria,1G7HK@1117|Cyanobacteria,1HCVC@1150|Oscillatoriales 1117|Cyanobacteria S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_51263_5 1537917.JU82_06055 1.26e-34 126.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42MF8@68525|delta/epsilon subdivisions,2YN61@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_801507_1 314278.NB231_13241 1.92e-78 243.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1WZWK@135613|Chromatiales 135613|Chromatiales G pfkB family carbohydrate kinase - - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_968500_1 1125863.JAFN01000001_gene1776 3.75e-61 200.0 COG1150@1|root,COG1150@2|Bacteria,1R1YD@1224|Proteobacteria,43DCI@68525|delta/epsilon subdivisions,2X8II@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - - k59_1001624_1 1168034.FH5T_14625 7.21e-105 314.0 COG2115@1|root,COG2115@2|Bacteria,4NEBQ@976|Bacteroidetes,2FN9P@200643|Bacteroidia 976|Bacteroidetes G Xylose isomerase xylA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_544146_1 880073.Calab_0629 4.61e-96 291.0 COG0045@1|root,COG0045@2|Bacteria,2NNQA@2323|unclassified Bacteria 2|Bacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_609589_1 1132855.KB913035_gene491 1.84e-69 227.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,2W0DD@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_1033044_1 1392490.JHZX01000001_gene2285 7.31e-64 207.0 COG3867@1|root,COG3867@2|Bacteria,4NI3G@976|Bacteroidetes,1I0YN@117743|Flavobacteriia 976|Bacteroidetes G Arabinogalactan endo-beta-1,4-galactanase - - 3.2.1.89 ko:K01224 - - - - ko00000,ko01000 - - - Glyco_hydro_53 k59_576519_1 886379.AEWI01000008_gene695 1.1e-110 341.0 COG3291@1|root,COG3291@2|Bacteria,4NJAF@976|Bacteroidetes,2FQYI@200643|Bacteroidia,3XJSV@558415|Marinilabiliaceae 976|Bacteroidetes G Pkd domain containing protein - - - - - - - - - - - - PKD k59_675379_1 1500894.JQNN01000001_gene4198 2.04e-32 129.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,2VII5@28216|Betaproteobacteria,472HY@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_642728_3 1454004.AW11_03750 2.55e-40 135.0 COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,2VURH@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Excinuclease ABC, C subunit - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_838205_1 563040.Saut_1150 3.93e-24 99.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2YMTU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_838205_2 291112.PAU_00857 5.19e-06 51.2 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_512995_1 323259.Mhun_1141 4.67e-63 216.0 COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2N916@224756|Methanomicrobia 224756|Methanomicrobia G PEP-utilising enzyme, TIM barrel domain - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_676006_1 1236497.BAJQ01000066_gene1017 6.51e-05 48.1 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FQ9Z@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_544806_1 1304883.KI912532_gene2235 1.62e-55 181.0 COG0500@1|root,COG2226@2|Bacteria,1RKQD@1224|Proteobacteria,2VQJ7@28216|Betaproteobacteria,2KUBG@206389|Rhodocyclales 206389|Rhodocyclales Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_806008_1 742767.HMPREF9456_01045 3.27e-31 122.0 COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,2FPF3@200643|Bacteroidia,22VZ6@171551|Porphyromonadaceae 976|Bacteroidetes C Citrate synthase, C-terminal domain prpC - 2.3.3.1,2.3.3.5 ko:K01647,ko:K01659 ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351,R00931 RC00004,RC00067,RC00406,RC02827 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_806008_2 78898.MVEG_03783T0 2.45e-15 75.9 COG0538@1|root,KOG1526@2759|Eukaryota,38CG3@33154|Opisthokonta,3NVZ4@4751|Fungi 4751|Fungi C Belongs to the isocitrate and isopropylmalate dehydrogenases family IDP1 GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006102,GO:0006139,GO:0006520,GO:0006536,GO:0006537,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009060,GO:0009062,GO:0009064,GO:0009084,GO:0009117,GO:0009295,GO:0009987,GO:0015980,GO:0016042,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019395,GO:0019637,GO:0019752,GO:0030258,GO:0031974,GO:0032787,GO:0034440,GO:0034641,GO:0042579,GO:0042645,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0072350,GO:0072524,GO:1901360,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - iMM904.YLR174W,iND750.YLR174W Iso_dh k59_614147_3 360104.CCC13826_1361 1.8e-28 112.0 COG1192@1|root,COG1192@2|Bacteria,1PZND@1224|Proteobacteria,42QVU@68525|delta/epsilon subdivisions,2YNYU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Involved in chromosome partitioning - - - - - - - - - - - - CbiA k59_614147_6 861455.HMPREF9184_00079 1.45e-21 97.1 COG4185@1|root,COG4185@2|Bacteria,1V1MA@1239|Firmicutes 1239|Firmicutes S Zeta toxin - - 2.7.1.176 ko:K16214 - - - - ko00000,ko01000,ko02048 - - - Zeta_toxin k59_940702_1 1278309.KB907099_gene2740 7.1e-49 157.0 COG2944@1|root,COG2944@2|Bacteria,1MZGM@1224|Proteobacteria,1S97H@1236|Gammaproteobacteria,1XKJH@135619|Oceanospirillales 135619|Oceanospirillales K Helix-turn-helix - - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_31 k59_940702_2 1278309.KB907099_gene2739 5.24e-39 132.0 COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,1S6BG@1236|Gammaproteobacteria,1XMEE@135619|Oceanospirillales 135619|Oceanospirillales S Cytotoxic translational repressor of toxin-antitoxin stability system - - - - - - - - - - - - RelE k59_449602_1 765911.Thivi_3166 1.13e-38 133.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1WY8Z@135613|Chromatiales 135613|Chromatiales S Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_614148_1 751994.AGIG01000031_gene278 0.000348 43.1 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1J4W7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_614148_2 225937.HP15_3969 1.08e-10 65.9 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides - - - - - - - - - - - - PMT,PMT_2 k59_19834_1 1168034.FH5T_22115 1.03e-100 308.0 COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,2FNIQ@200643|Bacteroidia 976|Bacteroidetes L COG COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_221888_1 991905.SL003B_1091 2.33e-75 243.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,4BP7M@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA - - 6.2.1.1,6.2.1.16 ko:K01895,ko:K01907 ko00010,ko00280,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00280,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354,R01357 RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_449607_1 1121405.dsmv_3072 2.98e-153 453.0 COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2MHN0@213118|Desulfobacterales 28221|Deltaproteobacteria G Phosphofructokinase pfp - 2.7.1.11,2.7.1.90 ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_711581_1 1128111.HMPREF0870_01746 1.69e-32 121.0 COG1179@1|root,COG1179@2|Bacteria,1TQ7A@1239|Firmicutes,4H1WF@909932|Negativicutes 909932|Negativicutes H ThiF family - - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_711581_2 469618.FVAG_00286 2.05e-05 44.3 COG3118@1|root,COG3118@2|Bacteria,37AJY@32066|Fusobacteria 32066|Fusobacteria O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_221890_1 1173028.ANKO01000094_gene2611 3.67e-25 107.0 COG1680@1|root,COG1680@2|Bacteria,1G6GD@1117|Cyanobacteria,1HBFP@1150|Oscillatoriales 1117|Cyanobacteria V Beta-lactamase - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase k59_157323_2 1294142.CINTURNW_1083 9.26e-66 210.0 COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,248MV@186801|Clostridia,36EYN@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_318066_1 1168034.FH5T_21975 5.43e-99 296.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA k59_614155_1 1168034.FH5T_07775 2e-105 316.0 COG4591@1|root,COG4591@2|Bacteria,4NG04@976|Bacteroidetes,2FNHB@200643|Bacteroidia 976|Bacteroidetes M Efflux ABC transporter, permease protein lolE - - ko:K09808,ko:K09815 ko02010,map02010 M00242,M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125,3.A.1.15.3,3.A.1.15.5 - - FtsX,MacB_PCD k59_614155_2 487796.Flav2ADRAFT_0812 3.76e-08 52.8 COG0858@1|root,COG0858@2|Bacteria,4NSQJ@976|Bacteroidetes,1I2VE@117743|Flavobacteriia 976|Bacteroidetes J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_19841_1 391625.PPSIR1_26628 5.24e-55 191.0 COG3866@1|root,COG3866@2|Bacteria,1RFAV@1224|Proteobacteria,43BC1@68525|delta/epsilon subdivisions,2X6R3@28221|Deltaproteobacteria,2YUW5@29|Myxococcales 28221|Deltaproteobacteria G Right handed beta helix region - - - - - - - - - - - - Beta_helix k59_284723_1 1304275.C41B8_14955 3.58e-12 69.7 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_972779_1 863365.XHC_4219 8.05e-114 347.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1X34U@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_776788_1 187272.Mlg_0002 1.04e-57 192.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1WWQF@135613|Chromatiales 135613|Chromatiales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_481767_1 935848.JAEN01000001_gene3440 4.01e-31 119.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,2PWAM@265|Paracoccus 28211|Alphaproteobacteria C Iron-containing alcohol dehydrogenase mdh1 - 1.1.1.1,1.1.1.61 ko:K00001,ko:K00043 ko00010,ko00071,ko00350,ko00625,ko00626,ko00650,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220 - R00623,R00754,R01644,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_481767_2 1411123.JQNH01000001_gene398 1e-65 213.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRJV@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family ssdA - - - - - - - - - - - Aldedh k59_1006022_1 754477.Q7C_1608 5.76e-64 197.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,460TA@72273|Thiotrichales 72273|Thiotrichales J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_776793_1 998674.ATTE01000001_gene2777 1.44e-44 165.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales 72273|Thiotrichales P heavy metal translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_907429_2 1123393.KB891316_gene1511 2.34e-12 64.7 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,1KS0G@119069|Hydrogenophilales 119069|Hydrogenophilales F Queuosine biosynthesis protein QueC - - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_157341_1 1165841.SULAR_07855 1.63e-16 84.3 COG4257@1|root,COG4257@2|Bacteria 2|Bacteria V antibiotic catabolic process - - - - - - - - - - - - DUF5011,SLH k59_284735_1 1123326.JFBL01000001_gene1447 2.51e-25 107.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2YMSR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M apolipoprotein N-acyltransferase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_123474_1 498211.CJA_0138 2.93e-10 58.9 COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,1TB0N@1236|Gammaproteobacteria,1FHQ9@10|Cellvibrio 1236|Gammaproteobacteria S Peptidase propeptide and YPEB domain - - - - - - - - - - - - PepSY k59_123474_2 1232683.ADIMK_0262 1.18e-45 156.0 COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,1S2S2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Di-haem cytochrome c - - - - - - - - - - - - DHC k59_123474_3 314345.SPV1_01617 1.32e-12 63.5 COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria 1224|Proteobacteria C Domain of unknown function (DUF1924) shp - - - - - - - - - - - DUF1924 k59_353132_1 869213.JCM21142_104410 7.1e-68 209.0 COG0071@1|root,COG0071@2|Bacteria,4NQXY@976|Bacteroidetes,47R7Q@768503|Cytophagia 976|Bacteroidetes O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_517319_1 326298.Suden_0648 6.6e-52 174.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2YP3D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_614170_1 350058.Mvan_1143 1.24e-05 54.3 COG3012@1|root,COG3012@2|Bacteria,2GMRR@201174|Actinobacteria,234MG@1762|Mycobacteriaceae 201174|Actinobacteria S SEC-C motif - - - - - - - - - - - - SEC-C k59_56421_1 572544.Ilyop_0677 3.17e-59 186.0 COG4492@1|root,COG4492@2|Bacteria,37AFD@32066|Fusobacteria 32066|Fusobacteria S Belongs to the UPF0735 family - - 5.4.99.5 ko:K06209 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4 k59_56421_2 572544.Ilyop_0678 3.87e-45 150.0 COG0511@1|root,COG0511@2|Bacteria,37B1T@32066|Fusobacteria 32066|Fusobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA - - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_222626_1 55601.VANGNB10_cI1079 3.38e-21 94.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1XSKE@135623|Vibrionales 135623|Vibrionales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_222626_2 1537917.JU82_06940 1.43e-72 223.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2YNZB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_91586_1 1440053.JOEI01000048_gene1450 4.54e-13 69.7 COG3547@1|root,COG3547@2|Bacteria,2GNQB@201174|Actinobacteria 201174|Actinobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_385900_1 1057002.KB905371_gene410 2.29e-42 151.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_973458_1 1116472.MGMO_62c00020 1.09e-32 116.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1XFIW@135618|Methylococcales 135618|Methylococcales S Belongs to the HesB IscA family - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_614806_1 237368.SCABRO_03004 3.57e-23 97.4 COG5608@1|root,COG5608@2|Bacteria 2|Bacteria S Late embryogenesis abundant protein - - - - - - - - - - - - LEA_2 k59_417270_1 99598.Cal7507_2901 7e-46 166.0 COG1190@1|root,COG1190@2|Bacteria,1G0SA@1117|Cyanobacteria,1HMPN@1161|Nostocales 1117|Cyanobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iJN678.lysS KTSC,tRNA-synt_2,tRNA_anti-codon k59_91594_1 537013.CLOSTMETH_03890 2.27e-11 66.6 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,3WIMJ@541000|Ruminococcaceae 186801|Clostridia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_91594_2 1142394.PSMK_24270 3.84e-16 79.0 COG0587@1|root,COG0587@2|Bacteria,2IYGA@203682|Planctomycetes 203682|Planctomycetes L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_777454_1 869213.JCM21142_62421 2.91e-84 264.0 COG2265@1|root,COG2265@2|Bacteria,4NFP1@976|Bacteroidetes,47KB6@768503|Cytophagia 976|Bacteroidetes J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_158340_2 563040.Saut_0667 1.1e-46 156.0 COG3018@1|root,COG3018@2|Bacteria,1RGG9@1224|Proteobacteria,42P0S@68525|delta/epsilon subdivisions,2YQJK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S (Lipo)protein - - - ko:K09860 - - - - ko00000 - - - LPP20 k59_20791_1 749222.Nitsa_1308 1.23e-91 290.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2YMHZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_482285_1 1168034.FH5T_13420 1.72e-118 353.0 COG3291@1|root,COG3291@2|Bacteria,4NUFV@976|Bacteroidetes 976|Bacteroidetes S PKD domain - - - - - - - - - - - - PKD k59_712234_1 242619.PG_1260 8.86e-44 162.0 COG1327@1|root,COG1328@1|root,COG1327@2|Bacteria,COG1328@2|Bacteria,4NGPS@976|Bacteroidetes,2FNK4@200643|Bacteroidia,22WTK@171551|Porphyromonadaceae 976|Bacteroidetes FK Ribonucleoside-triphosphate reductase nrdD - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,NRDD k59_712234_2 585502.HMPREF0645_2683 5.77e-53 170.0 COG0756@1|root,COG0756@2|Bacteria,4NNI4@976|Bacteroidetes,2FR7A@200643|Bacteroidia 976|Bacteroidetes F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_1006645_1 189753.AXAS01000016_gene1505 1.54e-08 62.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2UPWB@28211|Alphaproteobacteria,3K3C4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - TPR_8,Trans_reg_C k59_743440_1 1131451.O1K_04151 7.33e-07 50.4 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X38I@135614|Xanthomonadales 135614|Xanthomonadales V Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_743440_2 305900.GV64_02520 1.34e-23 103.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XIQW@135619|Oceanospirillales 135619|Oceanospirillales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_777465_1 375286.mma_1830 2.49e-09 60.1 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2VNZZ@28216|Betaproteobacteria,478DQ@75682|Oxalobacteraceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_1006651_1 1168034.FH5T_17685 1.74e-71 223.0 COG1045@1|root,COG1045@2|Bacteria,4NGZ7@976|Bacteroidetes,2FM9U@200643|Bacteroidia 976|Bacteroidetes E serine O-acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_1006651_2 1121098.HMPREF1534_03724 6.62e-44 157.0 COG0116@1|root,COG0116@2|Bacteria,4NFJM@976|Bacteroidetes,2FMNN@200643|Bacteroidia,4AMR4@815|Bacteroidaceae 976|Bacteroidetes L Belongs to the methyltransferase superfamily rlmL - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_647619_1 1232437.KL661999_gene4710 7.47e-31 124.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2WM19@28221|Deltaproteobacteria,2MHT6@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM von Willebrand factor type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,TPR_1,TPR_16,TPR_2,VWA,VWA_2 k59_549752_1 1499967.BAYZ01000159_gene536 7.95e-59 191.0 COG3384@1|root,COG3384@2|Bacteria 2|Bacteria S 3-carboxyethylcatechol 2,3-dioxygenase activity - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA,LigB k59_582122_1 572544.Ilyop_1241 1.21e-91 280.0 COG4591@1|root,COG4591@2|Bacteria 2|Bacteria M lipoprotein localization to outer membrane - - - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD k59_614827_1 1129794.C427_4660 5.68e-76 251.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,46876@72275|Alteromonadaceae 1236|Gammaproteobacteria HJM RimK-like ATP-grasp domain cphA - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK k59_842584_1 1049564.TevJSym_bh00130 4.87e-35 130.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J5XC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_842584_2 438753.AZC_3383 9.61e-06 47.4 2AJUF@1|root,31AH0@2|Bacteria,1Q5MF@1224|Proteobacteria,2V6QY@28211|Alphaproteobacteria,3F1WH@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4381) - - - - - - - - - - - - DUF4381 k59_124341_1 226186.BT_2997 6.31e-20 84.3 29YQ5@1|root,30KJS@2|Bacteria,4NPZ1@976|Bacteroidetes,2FRT4@200643|Bacteroidia,4AQG1@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_482300_1 1268237.G114_06862 2.65e-17 81.6 COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria 1224|Proteobacteria C Pfam cytochrome c - - - ko:K17230 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001 - - - Cytochrom_C,Cytochrome_CBB3 k59_806719_2 387093.SUN_0248 1.39e-44 159.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2YNN7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_582141_2 1035197.HMPREF9999_01329 1.68e-10 63.9 COG1007@1|root,COG1007@2|Bacteria,4NF94@976|Bacteroidetes,2FNTS@200643|Bacteroidia,1WD6R@1283313|Alloprevotella 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_124345_1 1454004.AW11_03102 6.33e-64 202.0 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2WFSD@28216|Betaproteobacteria,1KQZF@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_353820_1 314285.KT71_06252 3.09e-36 140.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S876@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_1006670_1 335543.Sfum_0989 2.48e-21 96.7 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,2MQY9@213462|Syntrophobacterales 28221|Deltaproteobacteria E Peptidase dimerisation domain argE - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_650218_1 1192868.CAIU01000019_gene2653 2.99e-56 192.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43GY1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_683405_1 1040989.AWZU01000136_gene2097 3.47e-112 328.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,3JW1X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986,ko:K15342 - - - - ko00000,ko01000,ko02048,ko03400 - - - Cas_Cas1,GIIM,RVT_1 k59_878008_1 1123400.KB904749_gene721 1.04e-54 179.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,461X1@72273|Thiotrichales 72273|Thiotrichales O Proteasome subunit - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_126944_1 749222.Nitsa_2098 2.64e-66 217.0 COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2YMNZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G ABC transporter, ATP-binding protein - - - ko:K13926 - - - - ko00000 - - - ABC_tran k59_126944_2 990073.ATHU01000001_gene1071 2.55e-12 66.6 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43CKQ@68525|delta/epsilon subdivisions,2YTDV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V secretion protein HlyD - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_288791_1 1121405.dsmv_0170 4.27e-80 257.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHT0@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_618164_1 525378.HMPREF0793_0113 8.51e-12 66.2 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,4H9V5@91061|Bacilli,4GX5E@90964|Staphylococcaceae 91061|Bacilli M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU GO:0000270,GO:0000271,GO:0003674,GO:0003824,GO:0003977,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0030203,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase k59_618164_2 177437.HRM2_35160 4.59e-42 142.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,2MK6Z@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_585199_1 187272.Mlg_0398 3.04e-76 249.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_553162_1 715451.ambt_20885 8.63e-42 150.0 COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,469CJ@72275|Alteromonadaceae 1236|Gammaproteobacteria E Sodium/glutamate symporter gltS - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter k59_911673_1 883114.HMPREF9709_00953 5e-05 52.0 COG0668@1|root,COG0668@2|Bacteria,1TQXJ@1239|Firmicutes,24M2A@186801|Clostridia 186801|Clostridia M Conserved TM helix - - - - - - - - - - - - TM_helix k59_289405_1 1120948.KB903229_gene5185 3.54e-17 85.9 COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4DX45@85010|Pseudonocardiales 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_226509_1 640512.BC1003_1133 4.87e-111 357.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,1K087@119060|Burkholderiaceae 28216|Betaproteobacteria L Atp-dependent helicase hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_194297_1 887898.HMPREF0551_1484 4.67e-08 52.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2VQ2M@28216|Betaproteobacteria,1K1UB@119060|Burkholderiaceae 28216|Betaproteobacteria J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_194297_2 322710.Avin_12680 2.53e-64 204.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria 1236|Gammaproteobacteria D maF-like protein yhdE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf k59_194297_3 1049564.TevJSym_ak00680 2.98e-66 216.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1530 Ribonucleases G and E rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_455227_1 1356852.N008_05710 1.99e-90 283.0 COG1154@1|root,COG1154@2|Bacteria,4NDY5@976|Bacteroidetes,47JUB@768503|Cytophagia 976|Bacteroidetes H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,E1_dh,Transket_pyr,Transketolase_C k59_553950_1 439235.Dalk_3076 3.52e-44 164.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2MHX2@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_618813_1 754476.Q7A_524 3.98e-67 210.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,45ZUF@72273|Thiotrichales 72273|Thiotrichales S PFAM AAA domain (dynein-related subfamily) - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_289411_1 1304885.AUEY01000043_gene3620 8.6e-70 228.0 COG5337@1|root,COG5337@2|Bacteria,1QCJ4@1224|Proteobacteria,42QGZ@68525|delta/epsilon subdivisions,2WKE6@28221|Deltaproteobacteria,2MKTV@213118|Desulfobacterales 28221|Deltaproteobacteria M CotH kinase protein - - - - - - - - - - - - CotH k59_746920_1 1168034.FH5T_18800 5.02e-135 414.0 28HY3@1|root,2Z83I@2|Bacteria,4NHFN@976|Bacteroidetes,2FX5V@200643|Bacteroidia 976|Bacteroidetes S phosphoenolpyruvate carboxykinase (diphosphate) activity - - - - - - - - - - - - - k59_715823_1 566466.NOR53_138 7.5e-14 72.8 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,1J6SD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2199 FOG GGDEF domain pleD - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_715823_2 1249480.B649_04235 4.58e-28 111.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42MXQ@68525|delta/epsilon subdivisions,2YM9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0098 PALP,Thr_synth_N k59_60669_1 660470.Theba_2124 7.8e-06 53.9 COG1404@1|root,COG1404@2|Bacteria,2GCI9@200918|Thermotogae 200918|Thermotogae O Belongs to the peptidase S8 family - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_781489_1 237368.SCABRO_02340 6e-55 187.0 COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,2IZ5J@203682|Planctomycetes 203682|Planctomycetes T HDOD domain - - - - - - - - - - - - HDOD,Response_reg k59_781489_2 443143.GM18_2409 1.39e-05 46.2 COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1N17V@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K07641,ko:K07642,ko:K07711 ko02020,ko02024,map02020,map02024 M00449,M00450,M00502,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_127728_1 1047013.AQSP01000114_gene705 6.16e-179 509.0 COG3385@1|root,COG3385@2|Bacteria,2NQNF@2323|unclassified Bacteria 2|Bacteria L Domain of unknown function (DUF4372) - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_94744_1 522306.CAP2UW1_1517 4.23e-59 205.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,1KPWD@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_194328_1 1168034.FH5T_22130 7.02e-143 430.0 COG1452@1|root,COG1452@2|Bacteria,4NFWD@976|Bacteroidetes,2FM9F@200643|Bacteroidia 976|Bacteroidetes M Psort location OuterMembrane, score - - - - - - - - - - - - - k59_24584_1 428125.CLOLEP_01377 2.62e-39 136.0 2E0G5@1|root,32W28@2|Bacteria,1VAS0@1239|Firmicutes,24NYA@186801|Clostridia,3WNKT@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_390416_1 626887.J057_14655 5.21e-41 152.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,465MX@72275|Alteromonadaceae 1236|Gammaproteobacteria T Signal transduction histidine kinase pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_810489_1 1150469.RSPPHO_01246 2.52e-39 139.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,2JQSR@204441|Rhodospirillales 204441|Rhodospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_810489_2 864069.MicloDRAFT_00048570 4.92e-72 219.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,1JUM9@119045|Methylobacteriaceae 28211|Alphaproteobacteria J PFAM ribosomal protein L17 rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_60678_1 631362.Thi970DRAFT_03278 1.85e-36 139.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WWHI@135613|Chromatiales 135613|Chromatiales S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_16,VWA_2 k59_60678_2 857087.Metme_0109 9.64e-27 107.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1XDQK@135618|Methylococcales 135618|Methylococcales S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_878687_1 1081640.AGFU01000113_gene290 1.54e-06 46.6 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBSS@28211|Alphaproteobacteria,2K66A@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_878687_2 1248916.ANFY01000005_gene2835 2.02e-70 221.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_258160_1 644801.Psest_1109 4.73e-51 171.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1Z0SJ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_1304 GHMP_kinases_C,GHMP_kinases_N k59_945308_1 998674.ATTE01000001_gene2697 8.19e-32 123.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,463N3@72273|Thiotrichales 72273|Thiotrichales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_684366_2 1168034.FH5T_17000 1.71e-82 251.0 COG0788@1|root,COG0788@2|Bacteria,4NEGJ@976|Bacteroidetes,2FN3H@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_977342_2 555779.Dthio_PD1537 3.1e-34 121.0 COG0358@1|root,COG0358@2|Bacteria,1N8NW@1224|Proteobacteria,42WR7@68525|delta/epsilon subdivisions,2WS70@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Zinc finger, CHC2-type protein - - - - - - - - - - - - zf-CHC2 k59_977342_3 1121405.dsmv_3742 3.51e-48 161.0 COG0270@1|root,COG0270@2|Bacteria,1NE40@1224|Proteobacteria,42WBI@68525|delta/epsilon subdivisions,2WSDV@28221|Deltaproteobacteria,2MM55@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_94755_1 997296.PB1_11399 9.49e-12 73.9 COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1TT2K@1239|Firmicutes,4ISYS@91061|Bacilli,1ZRH6@1386|Bacillus 91061|Bacilli M NlpC/P60 family - - - - - - - - - - - - NLPC_P60,PG_binding_1 k59_650885_2 1168034.FH5T_10820 3.57e-132 397.0 COG1555@1|root,COG1555@2|Bacteria,4NE88@976|Bacteroidetes,2FP15@200643|Bacteroidia 976|Bacteroidetes L Psort location OuterMembrane, score - - - - - - - - - - - - HHH_3 k59_585869_1 1168034.FH5T_12085 1.27e-100 303.0 COG0104@1|root,COG0104@2|Bacteria,4NGRZ@976|Bacteroidetes,2FM8A@200643|Bacteroidia 976|Bacteroidetes F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_553997_2 1168034.FH5T_12005 4.01e-49 170.0 COG0008@1|root,COG0008@2|Bacteria,4NFCC@976|Bacteroidetes,2FMVI@200643|Bacteroidia 976|Bacteroidetes J Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_258173_1 1396141.BATP01000012_gene2697 6.66e-19 90.9 COG3210@1|root,COG4625@1|root,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis - - - - - - - - - - - - DUF4347,DUF637,He_PIG,Laminin_G_3,PATR,SdrD_B k59_911710_1 1232437.KL661988_gene188 1.5e-25 106.0 COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales 28221|Deltaproteobacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - - - - - - - - - - DisA_N,YbbR k59_455258_1 439235.Dalk_3899 4.14e-44 161.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42YDX@68525|delta/epsilon subdivisions,2WU5E@28221|Deltaproteobacteria,2MMV0@213118|Desulfobacterales 28221|Deltaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,Response_reg k59_289446_1 1335757.SPICUR_02735 5.75e-69 222.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_977354_1 749222.Nitsa_1883 1.86e-188 533.0 COG2171@1|root,COG2171@2|Bacteria,1MYKK@1224|Proteobacteria,42MHI@68525|delta/epsilon subdivisions,2YMU8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep_2,THDPS_M,THDPS_N k59_194377_1 933262.AXAM01000016_gene152 1.86e-34 125.0 COG2091@1|root,COG2091@2|Bacteria,1N7NG@1224|Proteobacteria,42WPP@68525|delta/epsilon subdivisions,2WRW2@28221|Deltaproteobacteria,2MM1E@213118|Desulfobacterales 28221|Deltaproteobacteria H 4'-phosphopantetheinyl transferase superfamily - - - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_1010263_1 497321.C664_04072 4.46e-80 259.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,2KU6T@206389|Rhodocyclales 206389|Rhodocyclales I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_390444_1 1137799.GZ78_09160 1.84e-101 313.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1XI8H@135619|Oceanospirillales 135619|Oceanospirillales E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_585895_1 1168034.FH5T_07060 1.18e-115 341.0 COG0686@1|root,COG0686@2|Bacteria,4NE8F@976|Bacteroidetes,2FP71@200643|Bacteroidia 976|Bacteroidetes C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_289465_1 1410633.JHWR01000008_gene1656 3.25e-06 51.2 COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,27JCD@186928|unclassified Lachnospiraceae 186801|Clostridia D Cell cycle protein ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_289465_2 500633.CLOHIR_01049 1.12e-35 131.0 COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia,25QYZ@186804|Peptostreptococcaceae 186801|Clostridia M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_258186_1 1123261.AXDW01000008_gene921 1.05e-50 181.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1X55Z@135614|Xanthomonadales 135614|Xanthomonadales M Lysin motif - - - - - - - - - - - - LysM,SLT k59_911726_1 1150474.JQJI01000016_gene547 0.0 1159.0 COG0610@1|root,COG0610@2|Bacteria,2GCME@200918|Thermotogae 200918|Thermotogae L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_455291_1 1385935.N836_16225 2.8e-153 432.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_420858_1 545264.KB898744_gene2002 2.27e-31 120.0 2C7AT@1|root,338A4@2|Bacteria,1NF74@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_420858_2 395494.Galf_1685 7.64e-15 76.3 COG1450@1|root,COG1450@2|Bacteria,1NC06@1224|Proteobacteria,2VR15@28216|Betaproteobacteria 28216|Betaproteobacteria NU Bacterial type II and III secretion system protein - - - - - - - - - - - - Secretin,Secretin_N k59_911727_1 1120988.AXWV01000061_gene420 1.41e-28 118.0 COG1397@1|root,COG1397@2|Bacteria,1NJFP@1224|Proteobacteria,1RQ82@1236|Gammaproteobacteria 1236|Gammaproteobacteria O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_455293_1 1230342.CTM_07376 6.3e-48 158.0 29CHX@1|root,2ZZGD@2|Bacteria,1V7PD@1239|Firmicutes,24HKB@186801|Clostridia,36IP9@31979|Clostridiaceae 186801|Clostridia S HutP hutP - - - - - - - - - - - HutP k59_715880_1 1458357.BG58_12495 2.56e-93 283.0 COG1804@1|root,COG1804@2|Bacteria,1PRUN@1224|Proteobacteria,2W94H@28216|Betaproteobacteria,1KCNE@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_585907_1 929558.SMGD1_0424 5.38e-102 325.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,42M05@68525|delta/epsilon subdivisions,2YNMZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Bacterial NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_945358_1 555079.Toce_0936 5e-08 52.8 COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia,42H5V@68295|Thermoanaerobacterales 186801|Clostridia L Reverse transcriptase-like rnhA - 3.1.26.4 ko:K03469,ko:K06864 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RVT_3 k59_945358_2 1128421.JAGA01000002_gene367 1.14e-17 90.9 COG0658@1|root,COG0658@2|Bacteria 2|Bacteria S establishment of competence for transformation comE - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_1042680_1 1537917.JU82_07200 1.55e-115 340.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,42KZV@68525|delta/epsilon subdivisions,2YM8J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase flgS - 2.7.13.3 ko:K02482,ko:K07710 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_455302_2 1122212.AULO01000011_gene582 3.74e-37 133.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1XJ71@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_226566_1 1168034.FH5T_10390 7.54e-118 353.0 COG1538@1|root,COG1538@2|Bacteria,4NGIX@976|Bacteroidetes,2FM9H@200643|Bacteroidia 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_878718_1 1249627.D779_2147 1e-50 162.0 COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,1WYI4@135613|Chromatiales 135613|Chromatiales P sulfur relay protein TusB DsrH - - - ko:K07237 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DsrH k59_878718_2 765912.Thimo_0146 2.93e-76 229.0 COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1WY53@135613|Chromatiales 135613|Chromatiales P Belongs to the DsrF TusC family dsrF - - ko:K07236 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DrsE k59_650934_1 1168034.FH5T_06025 1.07e-48 161.0 COG0297@1|root,COG0297@2|Bacteria,4NFP8@976|Bacteroidetes,2FN7D@200643|Bacteroidia 976|Bacteroidetes G Starch synthase, catalytic domain glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5 k59_650934_2 385682.AFSL01000014_gene2734 1.78e-32 120.0 COG0414@1|root,COG0414@2|Bacteria,4NFT9@976|Bacteroidetes,2FN90@200643|Bacteroidia,3XJUJ@558415|Marinilabiliaceae 976|Bacteroidetes H Pantoate-beta-alanine ligase panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_911739_2 106648.BBLJ01000001_gene2150 5.78e-06 51.2 COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,1T1GW@1236|Gammaproteobacteria,3NJY9@468|Moraxellaceae 1236|Gammaproteobacteria P TonB dependent receptor fhuA GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005623,GO:0009279,GO:0015643,GO:0016020,GO:0019867,GO:0019904,GO:0030312,GO:0030313,GO:0031975,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046790,GO:0046872,GO:0046914,GO:0048037,GO:0071944 - ko:K02014 - - - - ko00000,ko02000 1.B.14 - iECSE_1348.ECSE_0151,iECW_1372.ECW_m0147,iEKO11_1354.EKO11_3766,iEcolC_1368.EcolC_3509,iWFL_1372.ECW_m0147 Plug,STN,TonB_dep_Rec k59_258192_1 399739.Pmen_0675 2.6e-106 315.0 COG4663@1|root,COG4663@2|Bacteria,1MUA1@1224|Proteobacteria,1RYNZ@1236|Gammaproteobacteria,1YHEZ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria Q Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_554041_2 1220535.IMCC14465_16530 0.000196 41.6 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,4BQFP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_521897_1 1041146.ATZB01000016_gene1435 9.62e-94 286.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria,4B93D@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_746975_1 1168034.FH5T_16780 1.39e-122 365.0 COG1109@1|root,COG1109@2|Bacteria,4NFU7@976|Bacteroidetes,2FM0A@200643|Bacteroidia 976|Bacteroidetes G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II pgcA - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_162245_1 1216362.B437_09013 6.2e-28 114.0 COG0731@1|root,COG0731@2|Bacteria,378B0@32066|Fusobacteria 32066|Fusobacteria C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_14,Radical_SAM k59_715902_1 1203606.HMPREF1526_00893 3.27e-26 112.0 COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,36DEW@31979|Clostridiaceae 186801|Clostridia L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K02342,ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon k59_878725_1 290315.Clim_1775 1.48e-85 268.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1FEDY@1090|Chlorobi 1090|Chlorobi M Cupin 2, conserved barrel domain protein - - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_812147_1 709032.Sulku_0178 5.69e-102 317.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2YMH2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_946869_1 1123399.AQVE01000025_gene1955 9.15e-87 262.0 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,1S4HU@1236|Gammaproteobacteria,460GK@72273|Thiotrichales 72273|Thiotrichales L 3'-5' exonuclease - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_749177_1 563040.Saut_0928 3.58e-168 496.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YR2T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG1033 exporter of the RND superfamily protein - - - ko:K07003 - - - - ko00000 - - - MMPL k59_913898_1 1165841.SULAR_08749 3.25e-122 367.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2YMB1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iIT341.HP1532 GATase_6,SIS k59_588331_1 1172190.M947_04305 6.86e-87 271.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2YMHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_718169_1 1123070.KB899250_gene497 5.08e-08 59.7 COG0642@1|root,COG2205@2|Bacteria,46TQY@74201|Verrucomicrobia,2IVC3@203494|Verrucomicrobiae 203494|Verrucomicrobiae T HAMP domain - - - - - - - - - - - - HATPase_c,HisKA k59_848271_2 929558.SMGD1_2160 1.02e-42 155.0 COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,42PK9@68525|delta/epsilon subdivisions,2YNXX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Oxygen tolerance - - - - - - - - - - - - BatD k59_718177_1 1168034.FH5T_02100 2.78e-91 283.0 COG3507@1|root,COG3507@2|Bacteria,4NIHD@976|Bacteroidetes,2FQIF@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolases family 43 - - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - GH43_C,Glyco_hydro_43 k59_848275_1 1125863.JAFN01000001_gene2501 1.37e-18 79.7 COG1314@1|root,COG1314@2|Bacteria,1NJ1D@1224|Proteobacteria,42TKW@68525|delta/epsilon subdivisions,2WRA3@28221|Deltaproteobacteria 28221|Deltaproteobacteria U PFAM Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_848275_2 518766.Rmar_1476 6.77e-55 179.0 COG0149@1|root,COG0149@2|Bacteria,4NE2F@976|Bacteroidetes,1FJ92@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_324649_1 1123073.KB899244_gene262 4.8e-48 174.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3PQ@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_260397_1 1266925.JHVX01000004_gene1244 3.78e-83 265.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,373U8@32003|Nitrosomonadales 28216|Betaproteobacteria C NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_62579_1 1499967.BAYZ01000051_gene2776 7.45e-06 52.0 COG4591@1|root,COG4591@2|Bacteria 2|Bacteria M lipoprotein localization to outer membrane - - - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD k59_653115_1 1265503.KB905162_gene3650 4.35e-36 141.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,2Q73E@267889|Colwelliaceae 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_783636_1 1156937.MFUM_830007 4.45e-30 114.0 COG0071@1|root,COG0071@2|Bacteria,46T3G@74201|Verrucomicrobia,37GRX@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia O Hsp20/alpha crystallin family ibpA - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_228776_1 537972.ABQU01000006_gene339 1.85e-05 50.4 COG1020@1|root,COG4310@1|root,COG1020@2|Bacteria,COG4310@2|Bacteria,1NDWT@1224|Proteobacteria,42PN9@68525|delta/epsilon subdivisions,2YMYV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Domain of unknown function (DUF4910) - - - - - - - - - - - - DUF2172,DUF4910,HTH_47 k59_588398_1 1537917.JU82_01575 1.7e-94 290.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2YMQ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H acetolactate synthase ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_813079_1 870187.Thini_1320 1.92e-50 171.0 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat - - - ko:K07090 - - - - ko00000 - - - TauE,Trypsin_2 k59_783641_1 377629.TERTU_0744 3.2e-80 263.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,2PP8H@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_588409_1 471870.BACINT_00979 1.18e-102 327.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FM2D@200643|Bacteroidia,4AK7X@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_260454_1 1042377.AFPJ01000020_gene2065 1.01e-33 126.0 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,46BQ5@72275|Alteromonadaceae 1236|Gammaproteobacteria U Cation efflux family catA - - - - - - - - - - - Cation_efflux,ZT_dimer k59_260454_2 765914.ThisiDRAFT_0954 6.16e-27 109.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales 135613|Chromatiales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 k59_97147_1 1408433.JHXV01000011_gene2053 3.93e-11 67.0 COG1357@1|root,COG4733@1|root,COG1357@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - - - - - - - - - - Beta_helix,F5_F8_type_C,RicinB_lectin_2,Ricin_B_lectin,fn3 k59_97147_2 1122179.KB890416_gene2644 2.62e-18 84.7 COG3637@1|root,COG3637@2|Bacteria,4NE33@976|Bacteroidetes 976|Bacteroidetes M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_260462_1 1049564.TevJSym_ag01010 2.79e-47 172.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction Histidine kinase ntrY - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8 k59_423241_1 991.IW20_04000 5.63e-38 137.0 2DBMF@1|root,2Z9YG@2|Bacteria,4NPRW@976|Bacteroidetes,1I1PP@117743|Flavobacteriia,2NUUA@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_488244_1 1319815.HMPREF0202_01448 4.52e-208 602.0 COG0550@1|root,COG0550@2|Bacteria,37864@32066|Fusobacteria 32066|Fusobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_749278_1 583355.Caka_1445 2.81e-69 222.0 COG0501@1|root,COG0501@2|Bacteria,46TVV@74201|Verrucomicrobia,3K72R@414999|Opitutae 414999|Opitutae O Peptidase M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_97168_1 279714.FuraDRAFT_2454 4.13e-86 280.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,2KQ6F@206351|Neisseriales 206351|Neisseriales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_423248_1 616991.JPOO01000003_gene2686 2.4e-56 184.0 COG3622@1|root,COG3622@2|Bacteria,4NG74@976|Bacteroidetes,1HXKC@117743|Flavobacteriia,23H35@178469|Arenibacter 976|Bacteroidetes G Xylose isomerase-like TIM barrel - - 5.3.1.22 ko:K01816 ko00630,ko01100,map00630,map01100 - R01394 RC00511 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_749288_1 1121937.AUHJ01000050_gene1244 1.73e-83 259.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,464M3@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_228820_1 313596.RB2501_11227 5e-59 197.0 COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,1HXV2@117743|Flavobacteriia 976|Bacteroidetes S Peptidase m28 - - - - - - - - - - - - PA,Peptidase_M28 k59_848354_1 1123073.KB899241_gene1957 4.53e-68 229.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1X333@135614|Xanthomonadales 135614|Xanthomonadales I converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974 k59_97175_1 1121396.KB893104_gene1783 2.59e-70 226.0 28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,43DCS@68525|delta/epsilon subdivisions,2X8IT@28221|Deltaproteobacteria,2MK0X@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_97175_2 555779.Dthio_PD0022 2.03e-10 63.2 COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66 k59_718298_1 562982.HMPREF0432_00371 3.34e-30 117.0 COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,4HASX@91061|Bacilli,3WG2Y@539002|Bacillales incertae sedis 91061|Bacilli E Amino-transferase class IV ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iYO844.BSU38550 Aminotran_4 k59_813135_1 387093.SUN_1254 8.12e-44 155.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2YM9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_813135_2 387093.SUN_1246 5.51e-12 61.6 COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42VGZ@68525|delta/epsilon subdivisions,2YQ8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 k59_130306_2 933262.AXAM01000013_gene1297 9.06e-29 110.0 COG3166@1|root,COG3166@2|Bacteria,1Q1I0@1224|Proteobacteria,42W65@68525|delta/epsilon subdivisions,2WS79@28221|Deltaproteobacteria,2MK8I@213118|Desulfobacterales 28221|Deltaproteobacteria NU PFAM Fimbrial assembly pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_947622_1 1532557.JL37_22315 8.52e-71 242.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria 28216|Betaproteobacteria M mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_653207_1 1158318.ATXC01000001_gene783 3.15e-12 72.0 COG0072@1|root,COG0072@2|Bacteria,2G3KI@200783|Aquificae 200783|Aquificae J Phenylalanyl-tRNA synthetase, beta subunit pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_979679_1 765914.ThisiDRAFT_1528 1.26e-113 347.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales 135613|Chromatiales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_880966_1 330214.NIDE2144 7e-37 128.0 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - GO:0001666,GO:0006355,GO:0006950,GO:0008150,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010565,GO:0010605,GO:0010629,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036293,GO:0040008,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0062012,GO:0065007,GO:0070482,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - HTH_3,HTH_37 k59_1012436_1 1537917.JU82_01665 3.58e-95 309.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2YMP9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_979682_1 1499968.TCA2_0624 1.13e-10 64.7 COG1335@1|root,COG1335@2|Bacteria,1V8ER@1239|Firmicutes,4HIZB@91061|Bacilli,26XH2@186822|Paenibacillaceae 91061|Bacilli Q Isochorismatase family phzA - - - - - - - - - - - Isochorismatase k59_913993_1 1123073.KB899241_gene1773 1.29e-69 223.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1X34W@135614|Xanthomonadales 135614|Xanthomonadales C NADP transhydrogenase - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_130317_1 1163617.SCD_n02931 5.02e-38 147.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,2VS6Y@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N k59_718325_1 1165841.SULAR_01360 9.89e-77 254.0 COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2YMXW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cytochrome c biogenesis protein ccsBA - - - - - - - - - - - Cytochrom_C_asm,ResB k59_813162_1 207954.MED92_02279 1.03e-50 164.0 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XJZ5@135619|Oceanospirillales 135619|Oceanospirillales T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_813162_2 765911.Thivi_3095 6.77e-25 98.2 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales 135613|Chromatiales V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_979688_1 59538.XP_005981185.1 1.92e-25 109.0 2CMC3@1|root,2QPXZ@2759|Eukaryota,38CYT@33154|Opisthokonta 33154|Opisthokonta G feruloyl esterase activity faeB-1 GO:0000272,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010383,GO:0010393,GO:0010410,GO:0016052,GO:0016787,GO:0016788,GO:0016998,GO:0017144,GO:0030600,GO:0042737,GO:0042802,GO:0042803,GO:0043170,GO:0044036,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0045488,GO:0045490,GO:0045491,GO:0045493,GO:0046983,GO:0052689,GO:0071554,GO:0071704,GO:1901575 3.1.1.73 ko:K09252 - - - - ko00000,ko01000 - - - Tannase k59_62661_1 709032.Sulku_0882 4.26e-106 318.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2YMG2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_62661_2 709032.Sulku_0883 7.48e-60 191.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,42MJK@68525|delta/epsilon subdivisions,2YMV3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0400 LYTB k59_488272_1 572544.Ilyop_0916 9.62e-150 436.0 COG1454@1|root,COG1454@2|Bacteria,3792I@32066|Fusobacteria 32066|Fusobacteria C PFAM Iron-containing alcohol dehydrogenase fucO - 1.1.1.77 ko:K00048 ko00630,ko00640,ko01120,map00630,map00640,map01120 - R01781,R02257 RC00087,RC00099 ko00000,ko00001,ko01000 - - - Fe-ADH k59_488272_3 1321778.HMPREF1982_01455 3.79e-67 207.0 COG1051@1|root,COG1051@2|Bacteria,1V5NQ@1239|Firmicutes,24PPQ@186801|Clostridia,26C18@186813|unclassified Clostridiales 186801|Clostridia F NUDIX domain - - - - - - - - - - - - NUDIX k59_291832_1 1439940.BAY1663_01811 4.76e-50 181.0 COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - 2.1.1.80,3.1.1.61 ko:K03320,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_26748_1 316058.RPB_0191 1.94e-29 121.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3JQV4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GAF,GGDEF,PAS_3,PAS_4,PAS_7,PAS_8 k59_488278_1 379731.PST_2343 2.1e-92 296.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1YZWK@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_813175_1 1537917.JU82_10555 3.06e-20 91.7 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2YMP3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Highly conserved protein containing a thioredoxin domain - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_813175_2 709032.Sulku_1020 6.12e-54 179.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42M26@68525|delta/epsilon subdivisions,2YMEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S polyphosphate kinase ppk2 - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_783702_2 536227.CcarbDRAFT_1998 1.29e-74 246.0 COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,36FRJ@31979|Clostridiaceae 186801|Clostridia J tRNA nucleotidyltransferase poly(A) polymerase cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 k59_291836_1 1300150.EMQU_1964 3.78e-05 48.5 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,4H9TI@91061|Bacilli,4AZUE@81852|Enterococcaceae 91061|Bacilli I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_291836_2 572544.Ilyop_0593 8.09e-266 737.0 COG0064@1|root,COG0064@2|Bacteria,37976@32066|Fusobacteria 32066|Fusobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_979700_1 566466.NOR53_3005 4.19e-79 252.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,1J58C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2939 Carboxypeptidase C (cathepsin A) - - - - - - - - - - - - Peptidase_S10 k59_1012458_1 439235.Dalk_2680 1.04e-57 183.0 COG2197@1|root,COG2197@2|Bacteria,1NZMY@1224|Proteobacteria,430BP@68525|delta/epsilon subdivisions,2WVUJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM Response regulator receiver domain - - - - - - - - - - - - Response_reg k59_26755_1 1122604.JONR01000001_gene1738 1.33e-71 230.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1X3ED@135614|Xanthomonadales 135614|Xanthomonadales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_26755_2 1120953.AUBH01000001_gene1324 4.41e-12 66.2 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,464G4@72275|Alteromonadaceae 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_749361_1 519989.ECTPHS_00695 2.88e-148 432.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1WVVJ@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_97231_1 2340.JV46_26960 8.06e-85 275.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1J4E5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Cation transporter/ATPase, N-terminus ctpF - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_881679_4 1408422.JHYF01000004_gene1558 5.78e-212 604.0 COG5434@1|root,COG5434@2|Bacteria,1TQQW@1239|Firmicutes,24A0R@186801|Clostridia,36FGX@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_881679_5 1273538.G159_04395 3.97e-10 65.5 COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,4HFMP@91061|Bacilli,26E5B@186818|Planococcaceae 91061|Bacilli K FCD - - - - - - - - - - - - FCD,GntR k59_98018_1 1168034.FH5T_10295 1.36e-129 374.0 COG0180@1|root,COG0180@2|Bacteria,4NETX@976|Bacteroidetes,2FMAT@200643|Bacteroidia 976|Bacteroidetes J Belongs to the class-I aminoacyl-tRNA synthetase family trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_914859_1 1122173.AXVL01000005_gene363 6.3e-13 68.2 28NXH@1|root,2ZBV3@2|Bacteria,37BJ8@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_328161_1 929558.SMGD1_2417 1.5e-128 378.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2YNK3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1883 Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit - - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_328161_2 563040.Saut_1375 9.61e-09 55.5 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1R5RS@1224|Proteobacteria,42M3K@68525|delta/epsilon subdivisions,2YN6E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM biotin lipoyl attachment domain-containing protein pycB - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_622245_1 617140.AJZE01000090_gene4404 1.74e-07 60.5 COG1609@1|root,COG1609@2|Bacteria,1N4ND@1224|Proteobacteria,1RNR5@1236|Gammaproteobacteria,1XVKJ@135623|Vibrionales 135623|Vibrionales K Transcriptional regulator, LacI family - - - ko:K02529,ko:K03487 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_900_1 1500897.JQNA01000002_gene3347 4.78e-15 78.6 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2VKI5@28216|Betaproteobacteria,1K1JE@119060|Burkholderiaceae 28216|Betaproteobacteria C cytochrome - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_949129_1 42256.RradSPS_0888 1.18e-101 311.0 COG1115@1|root,COG1115@2|Bacteria,2GIU2@201174|Actinobacteria 201174|Actinobacteria E amino acid carrier protein alaP - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_262456_2 1168034.FH5T_14590 9.99e-125 361.0 COG2755@1|root,COG2755@2|Bacteria,4NMUB@976|Bacteroidetes,2FQW2@200643|Bacteroidia 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 k59_720361_2 387093.SUN_1750 1.95e-28 107.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2YT9B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D ABC transporter ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_981738_1 1168034.FH5T_12365 7.79e-115 342.0 COG2148@1|root,COG2148@2|Bacteria,4NFIA@976|Bacteroidetes,2FMUQ@200643|Bacteroidia 976|Bacteroidetes M sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_1014495_2 1168034.FH5T_05360 4.39e-105 308.0 COG0122@1|root,COG0122@2|Bacteria,4NMMI@976|Bacteroidetes,2FRRC@200643|Bacteroidia 976|Bacteroidetes L HhH-GPD superfamily base excision DNA repair protein - - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_1014495_3 411154.GFO_3184 2.23e-52 187.0 COG1629@1|root,COG4771@2|Bacteria,4NFZY@976|Bacteroidetes,1HYJ3@117743|Flavobacteriia 976|Bacteroidetes P Outer membrane receptor - - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec k59_720364_1 1049564.TevJSym_aa00470 1.21e-133 402.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1J4KB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family nirB - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2 k59_949134_1 314287.GB2207_07966 9.6e-11 61.6 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1J4ZK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_458895_1 1151118.KB895791_gene1899 3.42e-17 86.3 COG1361@1|root,COG1361@2|Bacteria,2I8F1@201174|Actinobacteria,1WBGC@1268|Micrococcaceae 201174|Actinobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11 k59_589634_2 1165841.SULAR_10094 1.34e-66 212.0 COG1999@1|root,COG1999@2|Bacteria,1R9EM@1224|Proteobacteria,42N5F@68525|delta/epsilon subdivisions 1224|Proteobacteria S protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems sco - - ko:K07152 - - - - ko00000,ko03029 - - - - k59_622266_1 632245.CLP_0965 1.87e-06 48.9 COG0369@1|root,COG2846@1|root,COG1151@2|Bacteria,COG2846@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia,36DDU@31979|Clostridiaceae 186801|Clostridia C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - DUF1858,Prismane k59_99223_1 1537917.JU82_02495 3.15e-81 243.0 COG0314@1|root,COG0314@2|Bacteria,1Q97D@1224|Proteobacteria,42REX@68525|delta/epsilon subdivisions,2YP4E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin converting factor moaE - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_99223_2 1249480.B649_11195 1.1e-30 110.0 COG1977@1|root,COG1977@2|Bacteria,1Q2EI@1224|Proteobacteria,42VIE@68525|delta/epsilon subdivisions,2YQ69@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin converting factor moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_1014506_1 1121396.KB893024_gene3901 1.97e-98 306.0 COG0223@1|root,COG0451@1|root,COG0223@2|Bacteria,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42QC6@68525|delta/epsilon subdivisions,2WIRV@28221|Deltaproteobacteria,2MMI1@213118|Desulfobacterales 28221|Deltaproteobacteria GJM Formyl transferase, C-terminal domain arnA - 1.1.1.305,2.1.2.13 ko:K10011,ko:K12449 ko00520,ko01100,ko01503,map00520,map01100,map01503 M00721,M00761 R01384,R01386,R07658,R07660 RC00026,RC00508,RC01575,RC01811,RC01812 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase,Formyl_trans_C,Formyl_trans_N k59_916_1 1249634.D781_2873 4.2e-20 89.4 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,3ZZRY@613|Serratia 1236|Gammaproteobacteria M Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) lpxL - 2.3.1.241,2.3.1.242 ko:K02517,ko:K12974 ko00540,ko01100,map00540,map01100 M00060 R05146,R10906 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_916_2 1196095.GAPWK_0560 4.02e-38 141.0 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,1RQE3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of the first glucose residue to the LPS core rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_transf_4,Glycos_transf_1 k59_393511_1 749222.Nitsa_2009 1.76e-135 395.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42M54@68525|delta/epsilon subdivisions,2YNPD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E COG0436 Aspartate tyrosine aromatic aminotransferase - - - - - - - - - - - - Aminotran_1_2 k59_491470_1 632335.Calkr_2455 2.67e-55 200.0 COG2730@1|root,COG3266@1|root,COG3401@1|root,COG2730@2|Bacteria,COG3266@2|Bacteria,COG3401@2|Bacteria,1TQR3@1239|Firmicutes,24896@186801|Clostridia,42FW7@68295|Thermoanaerobacterales 186801|Clostridia G FG-GAP repeat protein - - 4.2.2.23 ko:K18197 - - - - ko00000,ko01000 - PL11 - Big_4,CW_binding_1,Dockerin_1,Lipase_GDSL_2,RicinB_lectin_2,SLH k59_687688_1 1150621.SMUL_1003 2.17e-64 220.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,42P26@68525|delta/epsilon subdivisions,2YN89@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_262470_1 572544.Ilyop_0419 8.1e-30 107.0 COG1314@1|root,COG1314@2|Bacteria,37AM6@32066|Fusobacteria 32066|Fusobacteria U Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_262470_2 572544.Ilyop_0420 1.31e-161 465.0 COG2256@1|root,COG2256@2|Bacteria,3798D@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_164755_1 1207063.P24_14919 1.87e-52 172.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TSC5@28211|Alphaproteobacteria,2JPQ5@204441|Rhodospirillales 204441|Rhodospirillales V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_164755_2 1123368.AUIS01000009_gene2453 3.64e-79 243.0 COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,1T54P@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-2 type transporter - - - - - - - - - - - - ABC2_membrane k59_655102_1 96561.Dole_1510 8.54e-33 131.0 COG0823@1|root,COG0823@2|Bacteria,1NR8W@1224|Proteobacteria,42YPB@68525|delta/epsilon subdivisions,2WTWD@28221|Deltaproteobacteria 28221|Deltaproteobacteria U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_426080_1 1165841.SULAR_00100 1.75e-47 169.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MA6@68525|delta/epsilon subdivisions,2YMMG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V COG0841 Cation multidrug efflux pump - - - - - - - - - - - - ACR_tran k59_131930_1 882083.SacmaDRAFT_3191 4.13e-65 213.0 2DBMB@1|root,2Z9Y8@2|Bacteria,2I4DG@201174|Actinobacteria,4EDSK@85010|Pseudonocardiales 201174|Actinobacteria S Domain of unknown function (DUF4389) - - - - - - - - - - - - DUF4389 k59_164756_1 717785.HYPMC_0741 1.79e-73 230.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,3N6F2@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_916485_1 1168034.FH5T_20325 6.96e-65 199.0 COG0335@1|root,COG0335@2|Bacteria,4NNPW@976|Bacteroidetes,2FSHU@200643|Bacteroidia 976|Bacteroidetes J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_622267_1 1255043.TVNIR_2335 4.51e-07 49.3 COG1917@1|root,COG1917@2|Bacteria,1N0G1@1224|Proteobacteria,1SDYY@1236|Gammaproteobacteria,1WZKB@135613|Chromatiales 135613|Chromatiales S Cupin domain - - - - - - - - - - - - Cupin_2 k59_622267_2 572480.Arnit_2391 5.98e-194 550.0 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,43BTT@68525|delta/epsilon subdivisions,2YTGQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_622267_3 944547.ABLL_1009 2.88e-75 233.0 COG0454@1|root,COG0456@2|Bacteria,1Q5DX@1224|Proteobacteria,4313C@68525|delta/epsilon subdivisions,2YSF5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K acetyltransferase - - - - - - - - - - - - - k59_622267_4 316278.SynRCC307_2509 0.000337 42.4 2CKCQ@1|root,31FHN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_687694_1 1121468.AUBR01000014_gene2223 3.18e-70 228.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,42FNQ@68295|Thermoanaerobacterales 186801|Clostridia H Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_883808_2 387093.SUN_1105 8.03e-55 174.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,42TMC@68525|delta/epsilon subdivisions,2YPSJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FG (HIT) family - - - - - - - - - - - - HIT k59_883808_3 944547.ABLL_2066 5.97e-61 191.0 COG2406@1|root,COG2406@2|Bacteria,1RE25@1224|Proteobacteria,42PJ1@68525|delta/epsilon subdivisions,2YMUJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ferritin - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_818392_1 572544.Ilyop_0357 1.32e-313 881.0 COG0249@1|root,COG0249@2|Bacteria,378K4@32066|Fusobacteria 32066|Fusobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_753053_1 626887.J057_18585 3.13e-55 184.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,4650N@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_753053_2 1163617.SCD_n01357 2.91e-13 69.3 COG5660@1|root,32WII@2|Bacteria,1R3ME@1224|Proteobacteria 1224|Proteobacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_818400_1 1548905.A0A0A1IUN7_9CAUD 9.47e-56 197.0 4QF9I@10239|Viruses,4QTTB@28883|Caudovirales,4QN6Q@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_785676_1 985255.APHJ01000021_gene1683 2.32e-13 70.1 COG1381@1|root,COG1381@2|Bacteria,4NIBQ@976|Bacteroidetes,1I1E3@117743|Flavobacteriia,2P65U@244698|Gillisia 976|Bacteroidetes L Recombination protein O C terminal recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_785676_2 555500.I215_03610 1.89e-30 120.0 COG2352@1|root,COG2352@2|Bacteria,4NFC0@976|Bacteroidetes,1HWZI@117743|Flavobacteriia 976|Bacteroidetes C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_491495_1 1168034.FH5T_05195 1.04e-199 564.0 COG1668@1|root,COG1668@2|Bacteria,4NFSZ@976|Bacteroidetes,2FMUF@200643|Bacteroidia 976|Bacteroidetes CP ABC transporter permease natB - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_687712_1 387093.SUN_2020 7.91e-97 308.0 COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria,42RQ5@68525|delta/epsilon subdivisions,2YRDH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor type A domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_230122_1 1041138.KB890221_gene1283 2.46e-06 52.8 COG3920@1|root,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,2TSSQ@28211|Alphaproteobacteria,4B959@82115|Rhizobiaceae 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HATPase_c_2,HisKA_2,dCache_1 k59_230122_2 459495.SPLC1_S542200 2.83e-17 87.8 COG0642@1|root,COG2201@1|root,COG2201@2|Bacteria,COG2205@2|Bacteria,1G0TS@1117|Cyanobacteria,1H8JZ@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_230122_3 675813.VIB_002035 1.33e-167 489.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1XU31@135623|Vibrionales 135623|Vibrionales M BCCT, betaine/carnitine/choline family transporter - - - ko:K05020 - - - - ko00000,ko02000 2.A.15.1.1,2.A.15.1.11 - - BCCT k59_491500_1 1278309.KB907100_gene1921 6.2e-78 254.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,1RQYX@1236|Gammaproteobacteria,1XRSQ@135619|Oceanospirillales 135619|Oceanospirillales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_131967_1 1123326.JFBL01000007_gene658 4.02e-39 145.0 COG4269@1|root,COG4269@2|Bacteria 2|Bacteria T membrane yjgN GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF898 k59_1014542_1 1168034.FH5T_06720 5.17e-74 242.0 COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,2FMI1@200643|Bacteroidia 976|Bacteroidetes E peptidase S46 dpp7 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009987,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033218,GO:0034641,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_S46 k59_883837_1 765910.MARPU_06545 3.46e-79 253.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_687725_2 1249627.D779_4188 8.08e-19 83.6 COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales 135613|Chromatiales C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_655156_1 713586.KB900536_gene2898 1.77e-94 289.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_557047_1 1121403.AUCV01000002_gene621 9.1e-62 194.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SW0@68525|delta/epsilon subdivisions,2WPFF@28221|Deltaproteobacteria,2MK6E@213118|Desulfobacterales 28221|Deltaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_557047_2 525897.Dbac_0868 1.7e-17 81.6 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2M8F9@213115|Desulfovibrionales 28221|Deltaproteobacteria T Signal transducing histidine kinase homodimeric - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_66478_1 326298.Suden_1547 1.05e-181 538.0 COG1629@1|root,COG4771@2|Bacteria,1QZ2F@1224|Proteobacteria,42PWH@68525|delta/epsilon subdivisions,2YPE0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug k59_66478_2 944547.ABLL_2122 2.99e-65 202.0 COG0811@1|root,COG0811@2|Bacteria,1RK2P@1224|Proteobacteria,42RE4@68525|delta/epsilon subdivisions,2YP8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U tonB-system energizer ExbB exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_66478_3 944547.ABLL_2123 6.53e-50 162.0 COG0848@1|root,COG0848@2|Bacteria,1NE2Q@1224|Proteobacteria,42VAE@68525|delta/epsilon subdivisions,2YPUX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U transport protein ExbD expD - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_884096_3 644282.Deba_1313 3.46e-34 129.0 COG4625@1|root,COG4625@2|Bacteria,1N0QY@1224|Proteobacteria,4314D@68525|delta/epsilon subdivisions,2WWK5@28221|Deltaproteobacteria 28221|Deltaproteobacteria S pathogenesis - - - - - - - - - - - - - k59_884096_4 715451.ambt_15770 1.21e-38 143.0 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria,466Z3@72275|Alteromonadaceae 1236|Gammaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_655506_1 1117318.PRUB_13476 4.85e-06 51.2 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,2Q1M3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M protein involved in outer membrane biogenesis asmA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - ko:K07289 - - - - ko00000 - - - AsmA,AsmA_2 k59_655506_2 1123023.JIAI01000005_gene840 2.85e-25 105.0 COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4E21D@85010|Pseudonocardiales 201174|Actinobacteria E PFAM Peptidase family M20 M25 M40 - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_916979_1 768671.ThimaDRAFT_4847 1.8e-188 530.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales 135613|Chromatiales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_916979_2 870187.Thini_4460 2.81e-18 82.4 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,460E1@72273|Thiotrichales 72273|Thiotrichales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_393886_1 1163408.UU9_09957 8.73e-06 48.1 COG1668@1|root,COG1668@2|Bacteria,1R3RG@1224|Proteobacteria,1RQT1@1236|Gammaproteobacteria,1X3GM@135614|Xanthomonadales 135614|Xanthomonadales CP permease natB - - ko:K09696 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko02000 3.A.1.115 - - ABC2_membrane_2,ABC2_membrane_3 k59_393886_2 378806.STAUR_1024 1.37e-110 325.0 COG4555@1|root,COG4555@2|Bacteria,1QU2T@1224|Proteobacteria,43BX9@68525|delta/epsilon subdivisions,2X782@28221|Deltaproteobacteria,2YUK4@29|Myxococcales 28221|Deltaproteobacteria CP ABC transporter natA - 3.6.3.7 ko:K09697 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.115 - - ABC_tran k59_165215_1 194439.CT0670 4.52e-17 80.5 COG0725@1|root,COG0725@2|Bacteria 2|Bacteria P tungstate binding modA1 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0042597,GO:0043167,GO:0043168,GO:0044464 - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_491920_1 933262.AXAM01000030_gene825 1.92e-13 75.5 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PGC@68525|delta/epsilon subdivisions,2WKHK@28221|Deltaproteobacteria,2MJ4J@213118|Desulfobacterales 28221|Deltaproteobacteria T ATP-binding region ATPase domain protein - - - - - - - - - - - - FHA,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3 k59_557480_1 1123326.JFBL01000001_gene1266 1.26e-170 488.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,42MHB@68525|delta/epsilon subdivisions,2YNUZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase cofactor biosynthesis protein NifB - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_132370_1 985665.HPL003_25230 2.29e-60 200.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,4H9U2@91061|Bacilli,26RFS@186822|Paenibacillaceae 91061|Bacilli J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_132370_2 1122947.FR7_3212 1.83e-48 159.0 COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,4H4A5@909932|Negativicutes 909932|Negativicutes K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_622666_1 96561.Dole_0610 1.65e-95 306.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales 28221|Deltaproteobacteria K MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_393898_1 472759.Nhal_2813 9.93e-32 123.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_393898_2 1121456.ATVA01000012_gene2627 1.88e-27 104.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2WNCZ@28221|Deltaproteobacteria,2MB4E@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_230504_1 443152.MDG893_03300 5.15e-26 107.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,4651B@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990 Transket_pyr,Transketolase_C,Transketolase_N k59_786068_1 572544.Ilyop_0832 3.34e-205 589.0 COG3855@1|root,COG3855@2|Bacteria,378SX@32066|Fusobacteria 32066|Fusobacteria G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 fbp - 3.1.3.11 ko:K04041 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_2 k59_982136_1 416591.Tlet_1445 1.22e-18 89.0 COG1609@1|root,COG1609@2|Bacteria,2GC06@200918|Thermotogae 200918|Thermotogae K PFAM Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_557490_2 755178.Cyan10605_0151 1.27e-05 49.7 COG0763@1|root,COG0763@2|Bacteria,1G21F@1117|Cyanobacteria 1117|Cyanobacteria M lipid A disaccharide synthetase - - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - - k59_720785_1 469618.FVAG_01902 1.24e-173 516.0 COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3784G@32066|Fusobacteria 32066|Fusobacteria I acyl carrier protein - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,Acyltransferase,PP-binding k59_110579_1 1319815.HMPREF0202_02169 2.22e-124 362.0 COG0564@1|root,COG0564@2|Bacteria,378AR@32066|Fusobacteria 32066|Fusobacteria J Responsible for synthesis of pseudouridine from uracil - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_240803_1 1319815.HMPREF0202_01765 3.7e-110 334.0 COG2326@1|root,COG2326@2|Bacteria,37CBD@32066|Fusobacteria 32066|Fusobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_503633_1 746697.Aeqsu_0247 1.35e-05 46.6 COG3204@1|root,COG4935@1|root,COG3204@2|Bacteria,COG4935@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - HYR,LTD,Laminin_G_3 k59_503633_2 1408813.AYMG01000030_gene699 6.88e-12 64.7 COG4270@1|root,COG4270@2|Bacteria,4NQAY@976|Bacteroidetes,1IUDI@117747|Sphingobacteriia 976|Bacteroidetes S COGs COG4270 membrane protein - - - - - - - - - - - - DoxX,DoxX_2 k59_666772_1 880072.Desac_2134 3.36e-58 189.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MQFV@213462|Syntrophobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_894723_1 1168034.FH5T_12665 5.48e-262 737.0 COG0210@1|root,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,2FNIM@200643|Bacteroidia 976|Bacteroidetes L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_763522_1 272942.RCAP_rcc00669 1.03e-105 320.0 COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TUPK@28211|Alphaproteobacteria,1FBF7@1060|Rhodobacter 28211|Alphaproteobacteria H Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis in anaerobic conditions. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) bchE GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0033013,GO:0033014,GO:0034641,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.21.98.3 ko:K04034 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06268,R06269,R06270 RC00741,RC01491,RC01492 ko00000,ko00001,ko01000 - - - B12-binding,Fer4_12,Radical_SAM k59_536063_1 1168034.FH5T_21830 2.54e-117 345.0 COG2871@1|root,COG2871@2|Bacteria,4NFKC@976|Bacteroidetes,2FN44@200643|Bacteroidia 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF - 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_436288_1 748658.KB907314_gene234 3.87e-38 145.0 COG0651@1|root,COG0651@2|Bacteria,1N6BY@1224|Proteobacteria,1RR4C@1236|Gammaproteobacteria,1WWFY@135613|Chromatiales 135613|Chromatiales CP PFAM NADH Ubiquinone plastoquinone (complex I) - - - - - - - - - - - - Proton_antipo_M k59_272324_1 1280001.BAOA01000064_gene2634 2.65e-51 164.0 COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XXA8@135623|Vibrionales 135623|Vibrionales K Belongs to the P(II) protein family VV0993 - - - - - - - - - - - - k59_272324_2 29495.EA26_04895 1.69e-42 144.0 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XXFK@135623|Vibrionales 135623|Vibrionales T COG0517 FOG CBS domain - - - - - - - - - - - - CBS k59_633747_1 1283300.ATXB01000001_gene1708 4.26e-55 193.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1XEPA@135618|Methylococcales 1236|Gammaproteobacteria O Belongs to the peptidase S16 family - - - ko:K04770 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C k59_503642_1 471852.Tcur_2737 3.23e-20 93.2 COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4EI99@85012|Streptosporangiales 201174|Actinobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 k59_404106_1 326298.Suden_1943 1.35e-32 128.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2YN4S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_240809_2 573370.DMR_27960 3.35e-14 70.9 COG0695@1|root,COG0695@2|Bacteria,1NGUN@1224|Proteobacteria,42VF8@68525|delta/epsilon subdivisions,2WT7Q@28221|Deltaproteobacteria,2MGUI@213115|Desulfovibrionales 28221|Deltaproteobacteria O Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - Glutaredoxin k59_240809_3 1449345.JHWC01000010_gene1588 4.99e-08 60.5 COG1261@1|root,COG1261@2|Bacteria 2|Bacteria N bacterial-type flagellum organization flgA - - ko:K02279,ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 - - - ChapFlgA k59_176407_1 572544.Ilyop_0592 3.18e-140 410.0 COG0154@1|root,COG0154@2|Bacteria,3783S@32066|Fusobacteria 32066|Fusobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_436296_1 883081.HMPREF9698_01319 9.38e-16 76.3 COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,4HB89@91061|Bacilli,27FVW@186828|Carnobacteriaceae 91061|Bacilli D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_436296_2 1123318.KB904631_gene991 1.31e-21 97.1 COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,4HA6A@91061|Bacilli 91061|Bacilli U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_829287_1 1320556.AVBP01000013_gene1635 5.39e-58 189.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2TT4Q@28211|Alphaproteobacteria,43H4Q@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L uracil-DNA glycosylase udgA - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_77712_1 748449.Halha_2503 6e-80 247.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,24B6F@186801|Clostridia,3WBC8@53433|Halanaerobiales 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_928147_1 944435.AXAJ01000002_gene4311 5.79e-21 98.6 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1K1JT@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_404111_1 177437.HRM2_03040 1.1e-102 305.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MINF@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM 3-hydroxyacyl-CoA dehydrogenase domain protein - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_340297_1 305900.GV64_24190 8.64e-113 332.0 COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria,1S0ZS@1236|Gammaproteobacteria,1XH49@135619|Oceanospirillales 135619|Oceanospirillales G transporter - - - - - - - - - - - - DctP k59_110601_1 1121396.KB893035_gene3569 2.75e-93 302.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2X7WN@28221|Deltaproteobacteria,2MJWY@213118|Desulfobacterales 28221|Deltaproteobacteria EQ Hydantoinase oxoprolinase N-terminal region - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_536078_2 1123400.KB904791_gene127 3.76e-93 278.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,45ZXZ@72273|Thiotrichales 72273|Thiotrichales P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_601107_2 638303.Thal_0195 2.61e-16 84.0 COG1807@1|root,COG1807@2|Bacteria,2G4MF@200783|Aquificae 200783|Aquificae M PFAM glycosyl transferase family 39 - - - - - - - - - - - - PMT_2 k59_503662_1 1144313.PMI10_03697 2.86e-29 111.0 COG1595@1|root,COG1595@2|Bacteria,4NSVA@976|Bacteroidetes,1I0Q1@117743|Flavobacteriia,2NS8W@237|Flavobacterium 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_7769_2 765912.Thimo_3113 1.23e-41 150.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_793948_1 768671.ThimaDRAFT_2677 3.71e-36 129.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1WW7N@135613|Chromatiales 135613|Chromatiales K response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_793948_2 768671.ThimaDRAFT_2676 1.21e-17 84.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RPMH@1236|Gammaproteobacteria,1WXSN@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - HATPase_c k59_503663_1 425104.Ssed_2799 1.95e-32 125.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,2QEU3@267890|Shewanellaceae 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_240835_1 1201293.AKXQ01000003_gene2518 1.43e-41 147.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroF GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934 DAHP_synth_1 k59_993332_1 1123035.ARLA01000027_gene572 4e-41 152.0 COG0308@1|root,COG0308@2|Bacteria,4NGUB@976|Bacteroidetes,1HXVD@117743|Flavobacteriia,4C2I3@83612|Psychroflexus 976|Bacteroidetes M Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_698587_1 1249627.D779_0517 2.72e-11 69.3 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria,1WXKB@135613|Chromatiales 135613|Chromatiales S pfam php - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_144136_1 399795.CtesDRAFT_PD3269 6.64e-40 137.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,2VRSU@28216|Betaproteobacteria,4AEW7@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Lipocalin family protein - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_144136_2 383372.Rcas_2362 2.87e-88 283.0 COG5322@1|root,COG5322@2|Bacteria,2G7SR@200795|Chloroflexi,377XP@32061|Chloroflexia 32061|Chloroflexia S oxidoreductase activity - - - - - - - - - - - - - k59_829312_1 469383.Cwoe_2289 2.3e-63 218.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4CS56@84995|Rubrobacteria 84995|Rubrobacteria EI ArgK protein - - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_568343_1 1122605.KB893637_gene3371 5.85e-16 83.2 COG1028@1|root,COG2070@1|root,COG3321@1|root,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,4NJWH@976|Bacteroidetes,1IQ07@117747|Sphingobacteriia 976|Bacteroidetes IQ Ketoacyl-synthetase C-terminal extension - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,ketoacyl-synt k59_208940_2 929558.SMGD1_0800 1.48e-90 277.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2YMR4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_144143_1 398578.Daci_5148 4.39e-34 133.0 COG1073@1|root,COG1073@2|Bacteria,1QY08@1224|Proteobacteria,2VMYE@28216|Betaproteobacteria,4ABAM@80864|Comamonadaceae 28216|Betaproteobacteria S alpha beta - - - - - - - - - - - - - k59_404145_1 395494.Galf_2796 1.41e-54 198.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,44VBN@713636|Nitrosomonadales 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_503689_1 317025.Tcr_2112 6.11e-09 54.3 COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1SGF3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_666828_1 1168067.JAGP01000001_gene411 1.7e-39 139.0 COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S7BJ@1236|Gammaproteobacteria,462N7@72273|Thiotrichales 72273|Thiotrichales K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_208947_1 1168034.FH5T_20495 9.55e-114 344.0 COG0187@1|root,COG0187@2|Bacteria,4NE0P@976|Bacteroidetes,2FPG7@200643|Bacteroidia 976|Bacteroidetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_340339_1 1156937.MFUM_310009 2.8e-55 190.0 COG0433@1|root,COG0433@2|Bacteria,46WEP@74201|Verrucomicrobia 74201|Verrucomicrobia S Domain of unknown function DUF87 - - - - - - - - - - - - DUF87 k59_340339_2 1156937.MFUM_310008 5.12e-45 158.0 arCOG14100@1|root,2Z924@2|Bacteria 2|Bacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_7788_1 713586.KB900536_gene2898 1.62e-92 284.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_928189_2 1123514.KB905900_gene2089 4.08e-15 77.4 COG0526@1|root,COG0526@2|Bacteria,1RCTX@1224|Proteobacteria,1S4XW@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO Thioredoxin resA - - - - - - - - - - - AhpC-TSA,Redoxin k59_305486_1 1129794.C427_1285 6.12e-20 96.3 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,46A1V@72275|Alteromonadaceae 1236|Gammaproteobacteria S Insulinase (Peptidase family M16) ptrA - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_698613_1 1207063.P24_07414 1.49e-91 274.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2JPMG@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG,ThiS k59_208958_1 1165841.SULAR_09619 5.48e-108 315.0 COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,42TT9@68525|delta/epsilon subdivisions 1224|Proteobacteria O methyltransferase - - - - - - - - - - - - ICMT,PEMT k59_633816_1 1185653.A1A1_00735 2.32e-08 61.2 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26ECD@186818|Planococcaceae 91061|Bacilli E substrate-binding protein dppA_1 - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_7790_1 1122962.AULH01000005_gene2675 3.9e-06 50.8 COG4319@1|root,COG4319@2|Bacteria,1N8K3@1224|Proteobacteria,2UXUT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 k59_7790_2 225937.HP15_2575 6.4e-09 56.2 COG1024@1|root,COG1024@2|Bacteria,1R3Q4@1224|Proteobacteria,1RQ45@1236|Gammaproteobacteria,46CP5@72275|Alteromonadaceae 1236|Gammaproteobacteria I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_730401_1 469618.FVAG_00582 2.33e-92 283.0 COG0758@1|root,COG0758@2|Bacteria,378EC@32066|Fusobacteria 32066|Fusobacteria LU Psort location Cytoplasmic, score 8.96 dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_730401_2 572544.Ilyop_0525 4.55e-174 508.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,37864@32066|Fusobacteria 32066|Fusobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_829869_1 631362.Thi970DRAFT_04688 4.35e-85 262.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_272862_1 1384056.N787_06560 9.55e-37 137.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RRQE@1236|Gammaproteobacteria,1X7AT@135614|Xanthomonadales 135614|Xanthomonadales EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh_C k59_340957_1 720554.Clocl_2620 3.36e-107 316.0 COG1857@1|root,COG1857@2|Bacteria,1TRGS@1239|Firmicutes,24CU1@186801|Clostridia,3WNWZ@541000|Ruminococcaceae 186801|Clostridia L CRISPR-associated negative auto-regulator DevR/Csa2 cst2 - - ko:K19075 - - - - ko00000,ko02048 - - - DevR k59_568854_1 563040.Saut_1133 2.27e-53 183.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2YMYX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g,tRNA_bind k59_568854_2 563040.Saut_1132 4.56e-23 89.7 2AK4P@1|root,31AUI@2|Bacteria,1Q664@1224|Proteobacteria,42X10@68525|delta/epsilon subdivisions,2YQR8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_568854_3 679897.HMU00290 1.35e-21 91.3 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,42NRA@68525|delta/epsilon subdivisions,2YMJC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_928737_1 1307759.JOMJ01000004_gene2449 5.95e-47 154.0 2DENB@1|root,2ZNJM@2|Bacteria 2|Bacteria S Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_601728_1 1121403.AUCV01000009_gene1452 2.33e-101 305.0 arCOG03330@1|root,2Z82Q@2|Bacteria,1NS0Z@1224|Proteobacteria,42YE1@68525|delta/epsilon subdivisions,2WU19@28221|Deltaproteobacteria,2MN37@213118|Desulfobacterales 28221|Deltaproteobacteria S Methanol-cobalamin methyltransferase B subunit - - 2.1.1.90 ko:K04480 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00356 R04384,R09098 RC00035,RC01144,RC01145,RC02440 ko00000,ko00001,ko00002,ko01000 - - - MtaB k59_8128_1 472759.Nhal_0181 3.36e-43 146.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1WY2R@135613|Chromatiales 135613|Chromatiales U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_43813_1 709032.Sulku_1586 1.25e-150 429.0 COG2227@1|root,COG2227@2|Bacteria,1NN3B@1224|Proteobacteria,43C3V@68525|delta/epsilon subdivisions,2YTAM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs cmoB - - ko:K15257 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_9 k59_764232_1 445961.IW15_17070 3.22e-39 153.0 COG0419@1|root,COG3291@1|root,COG0419@2|Bacteria,COG3291@2|Bacteria,4NI5F@976|Bacteroidetes,1I1KV@117743|Flavobacteriia,3ZSGB@59732|Chryseobacterium 976|Bacteroidetes L ATPase involved in DNA repair - - - - - - - - - - - - CarbopepD_reg_2,PKD k59_144756_2 944546.ABED_0157 1.9e-29 117.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2YN5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_764238_1 1249480.B649_07590 3.92e-100 293.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2YM7S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_764238_2 387093.SUN_0191 1.96e-11 58.9 2E91V@1|root,30Y1X@2|Bacteria,1PJX6@1224|Proteobacteria,42XQB@68525|delta/epsilon subdivisions,2YQXZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_404735_1 765911.Thivi_2840 2.79e-31 127.0 COG2203@1|root,COG3829@1|root,COG4564@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4564@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVXT@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_4,dCache_2 k59_340974_1 96561.Dole_2004 2.7e-20 94.7 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1QW1M@1224|Proteobacteria 1224|Proteobacteria T SMART PAS domain containing protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - - k59_306122_1 519989.ECTPHS_14156 7.41e-48 158.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_340983_1 1168034.FH5T_13785 4.27e-35 135.0 2DNGK@1|root,32XDY@2|Bacteria,4NRJG@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_177107_1 1165841.SULAR_00280 1.45e-115 344.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42MXQ@68525|delta/epsilon subdivisions,2YM9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0098 PALP,Thr_synth_N k59_436898_1 391615.ABSJ01000026_gene114 3.39e-38 136.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,1S50X@1236|Gammaproteobacteria,1J761@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - FHA,Yop-YscD_cpl k59_436898_2 1163617.SCD_n02385 5.76e-18 82.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria 28216|Betaproteobacteria T protein phosphatase 2C domain protein pppL - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_764252_2 1408473.JHXO01000006_gene1029 1.14e-47 160.0 COG2427@1|root,COG2427@2|Bacteria,4P4Q4@976|Bacteroidetes,2FYBJ@200643|Bacteroidia 976|Bacteroidetes S Protein of unknown function (DUF1641) - - - - - - - - - - - - - k59_794346_1 765913.ThidrDRAFT_2876 4.21e-65 211.0 COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales 135613|Chromatiales O smart pdz dhr glgf - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_798932_2 929558.SMGD1_0175 6.21e-81 245.0 COG0288@1|root,COG0288@2|Bacteria,1MV1U@1224|Proteobacteria,42NUA@68525|delta/epsilon subdivisions,2YMIG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Reversible hydration of carbon dioxide cynT - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_900394_2 870187.Thini_0084 1.83e-28 104.0 COG3514@1|root,COG3514@2|Bacteria,1NAV1@1224|Proteobacteria,1S9TK@1236|Gammaproteobacteria,463K8@72273|Thiotrichales 72273|Thiotrichales S CopG antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_83038_1 1380394.JADL01000001_gene2806 2.74e-52 174.0 COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2TUVD@28211|Alphaproteobacteria,2JUI2@204441|Rhodospirillales 204441|Rhodospirillales S TPM domain - - - - - - - - - - - - TPM_phosphatase k59_83038_2 1565314.OA34_02470 1.24e-76 235.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42R4C@68525|delta/epsilon subdivisions,2YP0I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_409850_1 314282.PCNPT3_10450 3.3e-75 232.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,2QHXM@267894|Psychromonadaceae 1236|Gammaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736 Cytochrom_C_asm k59_1030396_1 1168289.AJKI01000002_gene2417 2.63e-71 239.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FW53@200643|Bacteroidia,3XITN@558415|Marinilabiliaceae 976|Bacteroidetes H TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_214902_1 1042375.AFPL01000056_gene2363 4.91e-56 193.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,464A9@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_182324_1 1408473.JHXO01000001_gene2384 5.88e-60 199.0 COG1449@1|root,COG1449@2|Bacteria,4NFXW@976|Bacteroidetes,2FMRY@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 57 family amyA - 3.2.1.1 ko:K07405 ko00500,ko01100,map00500,map01100 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH57 - Glyco_hydro_57 k59_834948_1 85643.Tmz1t_2955 1.96e-47 169.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,2KY1I@206389|Rhodocyclales 206389|Rhodocyclales C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_999025_1 242619.PG_1814 8.08e-16 80.1 COG0358@1|root,COG0358@2|Bacteria,4NENT@976|Bacteroidetes,2FMV1@200643|Bacteroidia,22WQI@171551|Porphyromonadaceae 976|Bacteroidetes L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_311239_1 1122603.ATVI01000005_gene3496 1.49e-49 179.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9IC@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - - k59_48689_1 471870.BACINT_00367 1.94e-29 118.0 COG3250@1|root,COG3250@2|Bacteria,4NEP8@976|Bacteroidetes,2FMRW@200643|Bacteroidia,4AN63@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_48689_2 555500.I215_10485 3.78e-06 47.8 COG3172@1|root,COG3172@2|Bacteria,4NEQF@976|Bacteroidetes,1HYEB@117743|Flavobacteriia 976|Bacteroidetes H Domain of unknown function (DUF4301) - - - - - - - - - - - - AAA_28,DUF4301 k59_672632_1 1168034.FH5T_12260 2.04e-100 313.0 COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,2FM7F@200643|Bacteroidia 976|Bacteroidetes C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_509676_1 655815.ZPR_0971 1.3e-55 178.0 2AVDM@1|root,31M58@2|Bacteria,4NUN6@976|Bacteroidetes,1I278@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4293) - - - - - - - - - - - - DUF4293 k59_215425_2 1150469.RSPPHO_01424 5.45e-16 83.6 COG0438@1|root,COG0438@2|Bacteria,1PEWP@1224|Proteobacteria,2V82X@28211|Alphaproteobacteria,2JWA7@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 k59_934173_1 1121405.dsmv_1096 5.62e-49 177.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2MMXV@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC transporter transmembrane region - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_640067_1 1255043.TVNIR_0850 1.02e-94 281.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_7 k59_346741_1 537013.CLOSTMETH_01242 1.39e-42 148.0 COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,3WIXN@541000|Ruminococcaceae 186801|Clostridia P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_346741_2 572479.Hprae_1776 0.000129 43.5 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,3WAJ5@53433|Halanaerobiales 186801|Clostridia K PFAM response regulator receiver phoP - - ko:K02483,ko:K07658,ko:K07668 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_150335_1 1121926.AXWO01000009_gene2760 1.27e-100 321.0 COG3507@1|root,COG5297@1|root,COG3507@2|Bacteria,COG5297@2|Bacteria,2IBFU@201174|Actinobacteria 201174|Actinobacteria G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - - k59_215441_1 1304885.AUEY01000030_gene2434 1.28e-61 212.0 COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria,2MI4C@213118|Desulfobacterales 28221|Deltaproteobacteria J CBS domain ccaA - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd k59_574524_1 1249480.B649_07215 4.28e-93 278.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2YM8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_311782_1 1177154.Y5S_00857 1.7e-28 121.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1XHAM@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_736393_1 1192034.CAP_3728 2.29e-45 164.0 COG3509@1|root,COG3509@2|Bacteria 2|Bacteria Q xylan catabolic process - GO:0005575,GO:0005576 - ko:K03932 - - - - ko00000 - CE1 - Abhydrolase_2,Big_3_3,CBM_2,Glyco_hydro_62,Inhibitor_I9,Peptidase_S8,RicinB_lectin_2 k59_799533_1 1216362.B437_06987 2.42e-81 263.0 COG0500@1|root,COG2267@1|root,COG0500@2|Bacteria,COG2267@2|Bacteria,378JY@32066|Fusobacteria 32066|Fusobacteria IQ Putative methyltransferase - - - - - - - - - - - - Hydrolase_4,Methyltransf_20 k59_378027_1 1048983.EL17_09005 3.36e-47 172.0 COG1435@1|root,COG1435@2|Bacteria,4NGX8@976|Bacteroidetes,47P5D@768503|Cytophagia 976|Bacteroidetes F SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_900950_1 552811.Dehly_0140 9.88e-95 291.0 COG2070@1|root,COG2070@2|Bacteria 2|Bacteria S nitronate monooxygenase activity ycf23 - 1.1.1.205,1.13.12.16 ko:K00088,ko:K00459 ko00230,ko00910,ko00983,ko01100,ko01110,map00230,map00910,map00983,map01100,map01110 M00050 R00025,R01130,R08240 RC00143,RC02207,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko04147 - - - DUF561,Glu_synthase,IMPDH,NMO k59_736402_1 1123326.JFBL01000001_gene1286 9.21e-186 527.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,42MMI@68525|delta/epsilon subdivisions,2YNPZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase protein alpha chain - - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_278336_1 326298.Suden_1813 8.81e-124 370.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2YQN3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_835560_1 349521.HCH_05002 1.06e-61 203.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1XHYI@135619|Oceanospirillales 135619|Oceanospirillales L Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates sbcB - 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_966396_2 765913.ThidrDRAFT_2617 1.11e-64 202.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,1WYNA@135613|Chromatiales 135613|Chromatiales S Belongs to the CinA family - - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_835562_1 1172190.M947_07150 1.19e-61 206.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,42QDE@68525|delta/epsilon subdivisions,2YMPN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_640096_2 631362.Thi970DRAFT_04274 6.51e-30 110.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1WY86@135613|Chromatiales 135613|Chromatiales K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II k59_49233_1 264198.Reut_B3628 1.7e-10 67.0 COG2885@1|root,COG2885@2|Bacteria,1QUVV@1224|Proteobacteria,2WH8W@28216|Betaproteobacteria,1KG6M@119060|Burkholderiaceae 28216|Betaproteobacteria M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_835576_1 768710.DesyoDRAFT_4298 3.84e-31 125.0 COG0840@1|root,COG0840@2|Bacteria,1V2KF@1239|Firmicutes,24DV5@186801|Clostridia 186801|Clostridia NT chemotaxis protein - - - - - - - - - - - - MCPsignal,PilJ k59_410433_1 1469245.JFBG01000086_gene1622 1.47e-101 317.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_215485_1 1304885.AUEY01000003_gene539 1.24e-60 201.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,2MICX@213118|Desulfobacterales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_13242_1 1168034.FH5T_21890 2.7e-210 595.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,2FN08@200643|Bacteroidia 976|Bacteroidetes C 2-oxoacid acceptor oxidoreductase, alpha subunit porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_704990_1 1408473.JHXO01000002_gene3910 2.02e-07 51.6 COG3038@1|root,COG3038@2|Bacteria,4NH0I@976|Bacteroidetes 976|Bacteroidetes C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_704990_3 98439.AJLL01000081_gene2462 2.31e-16 75.1 COG0724@1|root,COG0724@2|Bacteria,1G7Q7@1117|Cyanobacteria,1JIUW@1189|Stigonemataceae 1117|Cyanobacteria S RNA recognition motif - - - - - - - - - - - - RRM_1 k59_278352_1 272560.BPSS2028 4.32e-18 81.3 COG1309@1|root,COG1309@2|Bacteria,1RGJ3@1224|Proteobacteria,2VHGC@28216|Betaproteobacteria,1K5C8@119060|Burkholderiaceae 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_4,TetR_N k59_278352_2 1123073.KB899241_gene2636 4.38e-28 113.0 COG4805@1|root,COG4805@2|Bacteria,1PIM6@1224|Proteobacteria,1RRW7@1236|Gammaproteobacteria,1X3BX@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_607563_8 1510531.JQJJ01000008_gene3433 4.96e-05 52.0 COG3170@1|root,COG3170@2|Bacteria,1Q45C@1224|Proteobacteria,2U08F@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_835582_1 1211114.ALIP01000111_gene1257 4.57e-87 271.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1X3B2@135614|Xanthomonadales 135614|Xanthomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_378059_1 765420.OSCT_2000 1.8e-51 184.0 COG1026@1|root,COG1026@2|Bacteria,2G5Q4@200795|Chloroflexi,376S4@32061|Chloroflexia 32061|Chloroflexia S PFAM peptidase M16 domain protein - - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C k59_640123_2 1499683.CCFF01000017_gene1836 6.28e-08 55.1 COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,36FI0@31979|Clostridiaceae 186801|Clostridia C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_574561_2 318996.AXAZ01000092_gene4991 8.51e-14 67.8 COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2U7AD@28211|Alphaproteobacteria,3JYQU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_705010_1 563040.Saut_1271 1.94e-57 184.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,42NDZ@68525|delta/epsilon subdivisions,2YMJ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_705010_2 1172190.M947_01595 3.84e-18 83.2 COG2265@1|root,COG2265@2|Bacteria,1MY45@1224|Proteobacteria,43BHX@68525|delta/epsilon subdivisions,2YMEI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA) trmA - 2.1.1.35 ko:K00557 - - - - ko00000,ko01000,ko03016 - - - tRNA_U5-meth_tr k59_966427_1 945713.IALB_1795 4.33e-51 181.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HTH_18,Pkinase,TPR_19,TPR_2,TPR_8 k59_736450_2 1168034.FH5T_06225 2.72e-100 297.0 COG0652@1|root,COG0652@2|Bacteria,4NI3Q@976|Bacteroidetes,2FQYV@200643|Bacteroidia 976|Bacteroidetes O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_215515_1 215803.DB30_3907 4.22e-75 251.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,42T70@68525|delta/epsilon subdivisions,2WUHA@28221|Deltaproteobacteria,2YV4Y@29|Myxococcales 28221|Deltaproteobacteria F involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_410466_1 1121035.AUCH01000005_gene212 8.57e-29 115.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,2KV1H@206389|Rhodocyclales 206389|Rhodocyclales P Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_410466_2 572477.Alvin_0163 2.62e-09 61.2 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV-A pilus assembly ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_83693_1 1121405.dsmv_3365 5.91e-88 279.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM CoA-binding domain protein - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_901026_1 1437824.BN940_16696 1.84e-32 126.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,3T2N6@506|Alcaligenaceae 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_215527_1 1410608.JNKX01000020_gene27 5.53e-108 338.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FNZH@200643|Bacteroidia,4AKR8@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family bglB - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_278386_1 292415.Tbd_1990 5.13e-78 235.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,1KRJT@119069|Hydrogenophilales 119069|Hydrogenophilales E ACT domain - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_278386_2 641147.HMPREF9021_01712 3.4e-08 54.3 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,2KPCQ@206351|Neisseriales 206351|Neisseriales H acetolactate synthase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_542231_2 596154.Alide2_4315 1.74e-74 239.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria,4ABAZ@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_23,HTH_24,rve k59_49294_1 1236542.BALM01000001_gene64 1.06e-61 213.0 COG1629@1|root,COG4771@2|Bacteria,1R4PY@1224|Proteobacteria,1RYVW@1236|Gammaproteobacteria,2Q9VM@267890|Shewanellaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10 - - Plug,TonB_dep_Rec k59_278388_1 1121438.JNJA01000023_gene366 1.27e-19 95.1 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_770225_1 266264.Rmet_2935 7.75e-123 361.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,1K4Q2@119060|Burkholderiaceae 28216|Betaproteobacteria NU twitching motility protein pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_736468_1 983328.AFGH01000027_gene668 1.6e-24 102.0 2CIMF@1|root,32UGF@2|Bacteria,1N2T2@1224|Proteobacteria,42WS5@68525|delta/epsilon subdivisions,2YPNC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TrbM - - - - - - - - - - - - TrbM k59_215537_1 439235.Dalk_3626 2.4e-109 327.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,2MI99@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_966468_1 1408287.AXUR01000040_gene1146 1.01e-58 196.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,37907@32066|Fusobacteria 32066|Fusobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_966468_2 1319815.HMPREF0202_02342 3.24e-242 669.0 COG0343@1|root,COG0343@2|Bacteria,378C1@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_999681_2 1165841.SULAR_03327 1.43e-51 178.0 COG1721@1|root,COG1721@2|Bacteria 2|Bacteria E protein (some members contain a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - DUF58 k59_805168_1 1122919.KB905555_gene879 3.09e-40 153.0 COG1643@1|root,COG1643@2|Bacteria,1TPET@1239|Firmicutes,4HE8W@91061|Bacilli,26U7B@186822|Paenibacillaceae 91061|Bacilli L ATP-dependent helicase hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_547876_1 931276.Cspa_c40780 1.11e-60 202.0 COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,36F7N@31979|Clostridiaceae 186801|Clostridia C Belongs to the NiFe NiFeSe hydrogenase large subunit family hupL - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_352269_1 926692.AZYG01000085_gene856 6.71e-28 111.0 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales 186801|Clostridia L Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_352269_2 1249975.JQLP01000001_gene3504 3.2e-13 67.4 COG2963@1|root,COG2963@2|Bacteria,4NRTR@976|Bacteroidetes,1II7C@117743|Flavobacteriia 976|Bacteroidetes L COG2963 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_841109_1 1168034.FH5T_05945 1.63e-33 123.0 COG1806@1|root,COG1806@2|Bacteria,4P12P@976|Bacteroidetes 976|Bacteroidetes S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation - - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_841109_2 1168034.FH5T_05910 5.62e-52 171.0 28K48@1|root,2Z7TY@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4405) - - - - - - - - - - - - DUF4405 k59_579968_1 1168034.FH5T_14270 5.51e-74 244.0 COG1361@1|root,COG2866@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2866@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - - - - - - - - - - CHU_C,DUF11,HYR k59_805172_1 177437.HRM2_18460 3.5e-41 141.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,42R4H@68525|delta/epsilon subdivisions,2WNAD@28221|Deltaproteobacteria,2MJYH@213118|Desulfobacterales 28221|Deltaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_805172_2 1121405.dsmv_0166 1.78e-40 135.0 COG2052@1|root,COG2052@2|Bacteria,1N0KP@1224|Proteobacteria,42TSK@68525|delta/epsilon subdivisions,2WQHH@28221|Deltaproteobacteria,2MKN3@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the UPF0296 family - - - ko:K09777 - - - - ko00000 - - - DUF370 k59_710709_1 743720.Psefu_1531 1.25e-33 124.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1YW6M@136845|Pseudomonas putida group 1236|Gammaproteobacteria U PFAM MotA TolQ ExbB proton channel tolQ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_710709_2 396588.Tgr7_2233 2.23e-55 177.0 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1WYUJ@135613|Chromatiales 135613|Chromatiales S Tol-Pal system-associated acyl-CoA thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_188620_1 1168034.FH5T_06385 1.44e-63 207.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,2FP28@200643|Bacteroidia 976|Bacteroidetes S Tat pathway signal sequence domain protein - - - - - - - - - - - - GFO_IDH_MocA k59_122520_1 371731.Rsw2DRAFT_2982 4.36e-66 211.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TT0P@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_516268_1 1121918.ARWE01000001_gene242 0.000955 43.1 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,43T1Q@69541|Desulfuromonadales 28221|Deltaproteobacteria C Domain of unknown function - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,PFOR_II,POR,POR_N,TPP_enzyme_C k59_516268_2 644282.Deba_2838 1.73e-62 197.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42RCD@68525|delta/epsilon subdivisions,2WMUP@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit bamG - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_841118_1 523791.Kkor_1955 2.95e-44 161.0 COG0639@1|root,COG0639@2|Bacteria,1QEIM@1224|Proteobacteria,1RZDP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - - - - - - - - - - Metallophos k59_775893_1 1121033.AUCF01000016_gene5419 5.48e-38 137.0 COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2JPCP@204441|Rhodospirillales 204441|Rhodospirillales Q homogentisate 1,2-dioxygenase - - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_775893_2 1318628.MARLIPOL_00953 1.85e-28 112.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,4653T@72275|Alteromonadaceae 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadI - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_54808_1 314270.RB2083_1059 5.18e-72 232.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,3ZG8V@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_547908_1 697303.Thewi_0635 9.6e-56 187.0 COG0332@1|root,COG0332@2|Bacteria,1UY2Z@1239|Firmicutes,24CXX@186801|Clostridia,42HPK@68295|Thermoanaerobacterales 186801|Clostridia I 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_580004_1 666685.R2APBS1_0975 7.26e-93 293.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1X3IW@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_906688_1 522306.CAP2UW1_0969 5.19e-83 252.0 COG5424@1|root,COG5424@2|Bacteria,1QVK0@1224|Proteobacteria,2VMEZ@28216|Betaproteobacteria 28216|Betaproteobacteria H Iron-containing redox enzyme - - - - - - - - - - - - Haem_oxygenas_2 k59_906688_2 1045855.DSC_10660 2.24e-115 352.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1X5B0@135614|Xanthomonadales 135614|Xanthomonadales I AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_252857_1 1168034.FH5T_09815 1.3e-100 303.0 COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,2FM7Y@200643|Bacteroidia 976|Bacteroidetes L Belongs to the DEAD box helicase family deaD - - - - - - - - - - - DEAD,Helicase_C k59_122537_1 765912.Thimo_0956 1.23e-16 77.8 COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,1RSI6@1236|Gammaproteobacteria,1X2EM@135613|Chromatiales 135613|Chromatiales I Belongs to the enoyl-CoA hydratase isomerase family - - - ko:K13816 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001 - - - ECH_1 k59_122537_2 396588.Tgr7_0082 2.48e-17 84.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2QR@135613|Chromatiales 135613|Chromatiales T Histidine Phosphotransfer domain - - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg k59_383854_1 472759.Nhal_3602 2.94e-121 356.0 COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C7@1236|Gammaproteobacteria,1X2MB@135613|Chromatiales 135613|Chromatiales O Radical SAM superfamily - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_805195_2 929506.CbC4_0083 6.09e-108 325.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,36DDG@31979|Clostridiaceae 186801|Clostridia K transcriptional regulator - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_188650_1 760117.JN27_15075 5.57e-20 94.7 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2VIKH@28216|Betaproteobacteria,473Y5@75682|Oxalobacteraceae 28216|Betaproteobacteria L impB/mucB/samB family - - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_516313_1 75379.Tint_2645 2.96e-44 146.0 COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,2VJ9U@28216|Betaproteobacteria,1KKF6@119065|unclassified Burkholderiales 28216|Betaproteobacteria C 4Fe-4S dicluster domain - - - ko:K05796 - - - - ko00000 - - - Fer4,Fer4_11,Fer4_4,Fer4_6,Fer4_9 k59_383860_2 553217.ENHAE0001_0696 8.6e-06 48.5 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,3NR67@468|Moraxellaceae 1236|Gammaproteobacteria U MarC family integral membrane protein ychE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_252866_1 232721.Ajs_0146 8.89e-30 119.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQS@28216|Betaproteobacteria,4AGB5@80864|Comamonadaceae 28216|Betaproteobacteria K sigma54 specific, transcriptional regulator, Fis family - - - ko:K06714 - - - - ko00000,ko03000 - - - HTH_8,PAS_4,Sigma54_activat k59_939725_1 203122.Sde_0066 3.54e-65 205.0 COG0328@1|root,COG3341@1|root,COG0328@2|Bacteria,COG3341@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,4676A@72275|Alteromonadaceae 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Cauli_VI,RNase_H k59_741985_1 765913.ThidrDRAFT_1995 6.15e-19 80.9 2DQ0J@1|root,3348C@2|Bacteria,1NBQ2@1224|Proteobacteria,1SPMC@1236|Gammaproteobacteria,1X1A6@135613|Chromatiales 135613|Chromatiales S Chemoreceptor zinc-binding domain - - - - - - - - - - - - CZB k59_516323_1 1408473.JHXO01000010_gene3641 8.48e-50 177.0 COG0739@1|root,COG4413@1|root,COG0739@2|Bacteria,COG4413@2|Bacteria,4NJUQ@976|Bacteroidetes 976|Bacteroidetes M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23,UT k59_156194_1 399795.CtesDRAFT_PD4892 4.48e-09 62.8 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,4AAG0@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_679124_1 1203554.HMPREF1476_01834 1.38e-29 113.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,4PQCI@995019|Sutterellaceae 28216|Betaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_679124_2 765914.ThisiDRAFT_1964 1.02e-253 714.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales 135613|Chromatiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily - - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_580040_1 580332.Slit_1488 4.97e-105 321.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,44V0M@713636|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_481137_1 1235788.C802_01701 1.62e-55 191.0 COG0436@1|root,COG0436@2|Bacteria,4NJM7@976|Bacteroidetes,2G2PQ@200643|Bacteroidia,4AW2J@815|Bacteroidaceae 976|Bacteroidetes E Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_873453_1 77586.LPERR10G12290.1 3.39e-94 314.0 COG0145@1|root,COG5459@1|root,KOG1939@2759|Eukaryota,KOG2539@2759|Eukaryota,37JQ4@33090|Viridiplantae,3G86T@35493|Streptophyta,3KP35@4447|Liliopsida,3I8J7@38820|Poales 35493|Streptophyta E Hydantoinase B/oxoprolinase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005911,GO:0006518,GO:0006575,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009506,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017168,GO:0030054,GO:0034641,GO:0042219,GO:0043171,GO:0043603,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051187,GO:0055044,GO:0071704,GO:1901564,GO:1901565,GO:1901575 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_547948_1 114615.BRADO4377 3.9e-15 74.7 COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,2TTUH@28211|Alphaproteobacteria,3K323@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S homolog of phage Mu protein gp47 - - - - - - - - - - - - Baseplate_J k59_547948_2 1121403.AUCV01000028_gene2425 2.14e-51 182.0 COG3299@1|root,COG3299@2|Bacteria,1P3E0@1224|Proteobacteria,42P2M@68525|delta/epsilon subdivisions,2WJIM@28221|Deltaproteobacteria,2MNMN@213118|Desulfobacterales 28221|Deltaproteobacteria S homolog of phage Mu protein gp47 - - - - - - - - - - - - Baseplate_J k59_122561_1 929558.SMGD1_1851 1.91e-62 206.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2YMTP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_481140_1 1265505.ATUG01000001_gene4613 3.69e-46 162.0 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,42PMY@68525|delta/epsilon subdivisions,2WPU5@28221|Deltaproteobacteria,2MM4P@213118|Desulfobacterales 28221|Deltaproteobacteria G Polysaccharide deacetylase - - - ko:K11931 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - Polysacc_deac_1 k59_742631_1 439235.Dalk_3917 3.52e-49 179.0 COG0784@1|root,COG2198@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2X756@28221|Deltaproteobacteria,2MPM5@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,MASE1,PAS_9,Response_reg k59_679844_1 1121481.AUAS01000004_gene1654 1.11e-100 302.0 COG0408@1|root,COG0408@2|Bacteria,4NFZS@976|Bacteroidetes,47M0F@768503|Cytophagia 976|Bacteroidetes H PFAM coproporphyrinogen III oxidase hemF - 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_157129_1 1232410.KI421425_gene1549 7.12e-67 227.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_284544_1 745411.B3C1_06703 1.77e-68 218.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1J4PY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - iYL1228.KPN_03597,ic_1306.c3945 polyprenyl_synt k59_123291_1 572544.Ilyop_0840 4.62e-97 301.0 COG1493@1|root,COG1493@2|Bacteria,378H8@32066|Fusobacteria 32066|Fusobacteria H Belongs to the HPrK P family hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_972639_1 324925.Ppha_1998 6.14e-61 198.0 COG0725@1|root,COG0725@2|Bacteria,1FDY9@1090|Chlorobi 1090|Chlorobi P TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_972639_2 1121445.ATUZ01000013_gene977 7.25e-39 141.0 COG4149@1|root,COG4149@2|Bacteria,1RFSB@1224|Proteobacteria,42S5D@68525|delta/epsilon subdivisions,2X5VT@28221|Deltaproteobacteria,2MGYY@213115|Desulfovibrionales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_972639_3 457396.CSBG_02284 7.41e-44 158.0 COG1118@1|root,COG1118@2|Bacteria,1UI1E@1239|Firmicutes,25EAE@186801|Clostridia,36EU6@31979|Clostridiaceae 186801|Clostridia P the current gene model (or a revised gene model) may contain a frame shift modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran k59_972639_4 588581.Cpap_2736 1.66e-86 266.0 COG0157@1|root,COG0157@2|Bacteria,1UYJZ@1239|Firmicutes,24AV1@186801|Clostridia,3WHK9@541000|Ruminococcaceae 186801|Clostridia H Belongs to the NadC ModD family modD - - ko:K03813 - - - - ko00000,ko01000 - - - QRPTase_C,QRPTase_N k59_972639_5 572544.Ilyop_1395 1.87e-84 258.0 COG0725@1|root,COG0725@2|Bacteria,37A0K@32066|Fusobacteria 32066|Fusobacteria P ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_19702_1 1442599.JAAN01000022_gene1752 1.6e-77 253.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1X336@135614|Xanthomonadales 135614|Xanthomonadales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_449424_1 366602.Caul_1215 4.08e-64 206.0 COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,2U45K@28211|Alphaproteobacteria,2KGD8@204458|Caulobacterales 204458|Caulobacterales S methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_776628_1 1121887.AUDK01000002_gene2146 7.53e-36 139.0 COG2335@1|root,COG2335@2|Bacteria,4NH49@976|Bacteroidetes,1HXZS@117743|Flavobacteriia,2NTDH@237|Flavobacterium 976|Bacteroidetes M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - ko:K19519 - - - - ko00000,ko04516 - - - Fasciclin k59_580966_1 1499967.BAYZ01000056_gene4910 5.55e-57 187.0 COG1149@1|root,COG1149@2|Bacteria,2NPAY@2323|unclassified Bacteria 2|Bacteria C CobQ/CobB/MinD/ParA nucleotide binding domain - - - - - - - - - - - - CbiA,Fer4 k59_284548_1 748449.Halha_1329 1.13e-05 48.1 COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,24AE3@186801|Clostridia,3WB00@53433|Halanaerobiales 186801|Clostridia GK ROK family - - - - - - - - - - - - HTH_24,ROK k59_55541_1 1156919.QWC_26283 7.14e-120 370.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,3T8VD@506|Alcaligenaceae 28216|Betaproteobacteria M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_416503_1 314270.RB2083_140 8.95e-107 318.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TR8F@28211|Alphaproteobacteria,3ZGY9@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases soxH - - - - - - - - - - - Lactamase_B k59_449436_1 177439.DP1202 5e-92 285.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_874218_1 710111.FraQA3DRAFT_3344 8.47e-55 196.0 COG3321@1|root,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4EU82@85013|Frankiales 201174|Actinobacteria Q Beta-ketoacyl synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_907300_1 1168034.FH5T_10630 7.16e-79 243.0 COG1088@1|root,COG1088@2|Bacteria,4NE9V@976|Bacteroidetes,2FMUH@200643|Bacteroidia 976|Bacteroidetes M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_907300_2 1168034.FH5T_10645 3.82e-83 249.0 COG0228@1|root,COG0228@2|Bacteria,4NNY8@976|Bacteroidetes,2FN6N@200643|Bacteroidia 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_1005889_1 629265.PMA4326_15024 2.89e-110 332.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria,1Z50F@136849|Pseudomonas syringae group 1236|Gammaproteobacteria C Aldehyde dehydrogenase family mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_517149_1 1122604.JONR01000006_gene2661 1.16e-09 62.0 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1XD6G@135614|Xanthomonadales 135614|Xanthomonadales HP TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_517149_2 566466.NOR53_3244 3.42e-41 142.0 2ET5N@1|root,33KPQ@2|Bacteria,1NVZ1@1224|Proteobacteria,1SPQ8@1236|Gammaproteobacteria,1JACY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_805890_1 717773.Thicy_1351 1.83e-17 81.3 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,4603X@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_805890_2 83406.HDN1F_06640 4.4e-37 130.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1J66P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the MraZ family mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_776645_1 96561.Dole_2985 1.39e-67 211.0 2DM10@1|root,318W0@2|Bacteria,1MYJH@1224|Proteobacteria 1224|Proteobacteria S CRISPR-associated protein, Cse2 family cse2 - - ko:K19046 - - - - ko00000,ko02048 - - - CRISPR_Cse2 k59_449446_1 1121405.dsmv_1157 8.96e-67 227.0 COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria,2MJ5S@213118|Desulfobacterales 28221|Deltaproteobacteria G alpha amylase catalytic - - - - - - - - - - - - Alpha-amylase,GDE_C,GDE_N k59_1037675_1 1406840.Q763_00740 5.98e-27 105.0 COG1137@1|root,COG1137@2|Bacteria,4NDUG@976|Bacteroidetes,1HX61@117743|Flavobacteriia,2NU9K@237|Flavobacterium 976|Bacteroidetes S ABC transporter lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_1037675_2 1168034.FH5T_04875 9.95e-72 223.0 COG0805@1|root,COG0805@2|Bacteria,4NEKM@976|Bacteroidetes,2FNUF@200643|Bacteroidia 976|Bacteroidetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_972661_1 1123393.KB891327_gene473 2.01e-79 242.0 COG2210@1|root,COG2210@2|Bacteria,1QCK1@1224|Proteobacteria,2WE8S@28216|Betaproteobacteria,1KSAI@119069|Hydrogenophilales 119069|Hydrogenophilales S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_284569_1 1168034.FH5T_10815 1.68e-77 242.0 COG0204@1|root,COG0204@2|Bacteria,4NGR9@976|Bacteroidetes,2FM79@200643|Bacteroidia 976|Bacteroidetes I Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Acyltransferase k59_253594_1 1255043.TVNIR_2381 2.64e-51 181.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWSK@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_907312_1 765912.Thimo_3618 3.14e-74 233.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_776655_1 1335757.SPICUR_07975 1.12e-87 270.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1WWCM@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_679900_1 1121403.AUCV01000060_gene3708 2.44e-26 106.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MI6F@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM aminotransferase class I and II yfdZ - 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_548943_1 504487.JCM19302_4124 4e-131 379.0 COG0445@1|root,COG0445@2|Bacteria,4NFNH@976|Bacteroidetes,1HWN4@117743|Flavobacteriia 976|Bacteroidetes D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_618449_1 443144.GM21_3331 2.35e-91 288.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_553445_1 1122604.JONR01000006_gene2654 6.37e-18 83.2 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1X48I@135614|Xanthomonadales 135614|Xanthomonadales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_553445_2 870187.Thini_2768 3.85e-12 65.5 COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,1S5W4@1236|Gammaproteobacteria,462TR@72273|Thiotrichales 72273|Thiotrichales OU of membrane protease - - - ko:K07340 - - - - ko00000 - - - NfeD k59_60136_1 742735.HMPREF9467_01920 2.04e-133 395.0 COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,259T5@186801|Clostridia,221S9@1506553|Lachnoclostridium 186801|Clostridia S Tripartite tricarboxylate transporter TctA family - - - - - - - - - - - - TctA k59_781088_1 1122165.AUHS01000038_gene2355 1.09e-29 115.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1JD90@118969|Legionellales 118969|Legionellales S Competence protein comF - - - - - - - - - - - Pribosyltran k59_127333_1 927658.AJUM01000043_gene782 1.07e-104 312.0 COG0492@1|root,COG0492@2|Bacteria,4PMJ9@976|Bacteroidetes,2G0D7@200643|Bacteroidia,3XJU4@558415|Marinilabiliaceae 976|Bacteroidetes O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Glutaredoxin,Pyr_redox_2 k59_747072_1 1168034.FH5T_18740 1.1e-75 231.0 COG1047@1|root,COG1047@2|Bacteria,4NM29@976|Bacteroidetes,2FM08@200643|Bacteroidia 976|Bacteroidetes G Peptidyl-prolyl cis-trans isomerase slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_747072_2 1168034.FH5T_18745 6.01e-45 154.0 COG0082@1|root,COG0082@2|Bacteria,4NDXJ@976|Bacteroidetes,2FNGP@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_715987_1 572544.Ilyop_1116 7.14e-220 629.0 COG0210@1|root,COG0210@2|Bacteria,378QF@32066|Fusobacteria 32066|Fusobacteria L K03657 DNA helicase II ATP-dependent DNA helicase PcrA pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_715987_2 572544.Ilyop_1117 1.58e-41 149.0 COG0053@1|root,COG0454@1|root,COG0053@2|Bacteria,COG0456@2|Bacteria,37A0H@32066|Fusobacteria 32066|Fusobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Cation_efflux,ZT_dimer k59_162328_1 1127673.GLIP_1742 2.27e-24 115.0 2DNHZ@1|root,32XM8@2|Bacteria,1QUVC@1224|Proteobacteria,1SBS8@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_162328_3 698769.JFBD01000010_gene2478 4.23e-17 92.0 COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,4HGKJ@91061|Bacilli 91061|Bacilli E Sodium:solute symporter family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_977483_1 864069.MicloDRAFT_00051620 2.46e-14 77.8 COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TV0G@28211|Alphaproteobacteria,1JXXZ@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_7,PAS_9,dCache_1 k59_846302_1 1168034.FH5T_18040 1.06e-54 184.0 COG3303@1|root,COG3303@2|Bacteria,4NG0P@976|Bacteroidetes,2FP37@200643|Bacteroidia 976|Bacteroidetes C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process nrfA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 k59_846302_2 1168034.FH5T_18035 4.88e-79 237.0 COG3005@1|root,COG3005@2|Bacteria,4NK7R@976|Bacteroidetes,2FPIJ@200643|Bacteroidia 976|Bacteroidetes C cytochrome c nitrate reductase, small subunit nrfH - - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT k59_194510_1 1537917.JU82_09380 8.74e-56 184.0 COG2265@1|root,COG2265@2|Bacteria,1MY45@1224|Proteobacteria,43BHX@68525|delta/epsilon subdivisions,2YMEI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA) trmA - 2.1.1.35 ko:K00557 - - - - ko00000,ko01000,ko03016 - - - tRNA_U5-meth_tr k59_127955_1 335543.Sfum_2379 5.47e-08 57.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MR92@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,PocR,Response_reg,dCache_1 k59_127955_2 411490.ANACAC_02772 2.92e-05 45.4 COG1896@1|root,COG1896@2|Bacteria,1V3MK@1239|Firmicutes,24IBW@186801|Clostridia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_60830_1 335543.Sfum_3043 1.74e-40 142.0 COG4752@1|root,COG4752@2|Bacteria,1RJ2G@1224|Proteobacteria,42SXX@68525|delta/epsilon subdivisions,2WP1I@28221|Deltaproteobacteria,2MQIJ@213462|Syntrophobacterales 28221|Deltaproteobacteria S SAM-dependent RNA methyltransferase - - - - - - - - - - - - Methyltrn_RNA_4 k59_781655_2 387092.NIS_1292 2.76e-23 92.8 COG2863@1|root,COG2863@2|Bacteria,1PDTH@1224|Proteobacteria,42W2E@68525|delta/epsilon subdivisions,2YQDN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c553 cccA - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_162340_1 1249627.D779_2151 9.54e-99 307.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2 k59_24732_1 1301100.HG529242_gene2276 4.5e-112 327.0 COG1741@1|root,COG1741@2|Bacteria,1TSV4@1239|Firmicutes,25D4Z@186801|Clostridia,36U76@31979|Clostridiaceae 186801|Clostridia S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin k59_24732_3 1033810.HLPCO_002390 2.98e-77 237.0 COG1182@1|root,COG1182@2|Bacteria 2|Bacteria I oxidoreductase activity, acting on other nitrogenous compounds as donors azoR GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008081,GO:0008150,GO:0008152,GO:0008770,GO:0009987,GO:0016787,GO:0016788,GO:0019752,GO:0032787,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704,GO:0140096 - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 k59_24732_4 536227.CcarbDRAFT_0486 4.62e-40 138.0 COG1846@1|root,COG1846@2|Bacteria,1VB3Q@1239|Firmicutes,25CPU@186801|Clostridia,36WYX@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_977495_1 1168034.FH5T_12700 1.28e-97 304.0 COG0480@1|root,COG0480@2|Bacteria,4NG4H@976|Bacteroidetes,2FN1G@200643|Bacteroidia 976|Bacteroidetes J elongation factor G fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_94910_1 572544.Ilyop_0766 3.91e-101 307.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,37907@32066|Fusobacteria 32066|Fusobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_846319_1 1168034.FH5T_00105 2.32e-07 52.0 COG0224@1|root,COG0224@2|Bacteria,4NM5H@976|Bacteroidetes,2FNPU@200643|Bacteroidia 976|Bacteroidetes C WbqC-like protein - - - - - - - - - - - - WbqC k59_651010_1 760154.Sulba_1304 1.29e-34 123.0 COG2863@1|root,COG2863@2|Bacteria 2|Bacteria C cytochrome - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_651010_2 1172190.M947_02695 2.69e-135 397.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42NYV@68525|delta/epsilon subdivisions,2YN1D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_810743_1 335543.Sfum_1225 7.55e-84 276.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MQUW@213462|Syntrophobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_258297_1 1168034.FH5T_20710 4.22e-89 273.0 COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,2FM7Y@200643|Bacteroidia 976|Bacteroidetes L Belongs to the DEAD box helicase family - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_322047_1 709032.Sulku_1539 3.46e-33 117.0 2AIYJ@1|root,319GA@2|Bacteria,1Q2NX@1224|Proteobacteria,42W0X@68525|delta/epsilon subdivisions,2YQ6Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_485969_1 1123008.KB905694_gene1557 1.01e-37 129.0 COG5646@1|root,COG5646@2|Bacteria,4NSDH@976|Bacteroidetes,2FUT6@200643|Bacteroidia,22YS9@171551|Porphyromonadaceae 976|Bacteroidetes S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 k59_485969_2 1434325.AZQN01000003_gene2612 1.8e-32 124.0 COG1609@1|root,COG1609@2|Bacteria,4NFB7@976|Bacteroidetes,47JAA@768503|Cytophagia 976|Bacteroidetes K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR,Peripla_BP_3 k59_162347_1 768671.ThimaDRAFT_2039 3.72e-77 249.0 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1WWQS@135613|Chromatiales 135613|Chromatiales Q PFAM Mammalian cell entry related - - - ko:K06192 - - - - ko00000 - - - MlaD k59_810745_1 1499967.BAYZ01000103_gene3733 3.9e-87 273.0 COG0008@1|root,COG0008@2|Bacteria,2NNRW@2323|unclassified Bacteria 2|Bacteria J tRNA synthetases class I (E and Q), anti-codon binding domain glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_618996_1 1121405.dsmv_3781 1.3e-94 288.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_258299_1 709032.Sulku_2482 7.98e-80 247.0 28M05@1|root,2ZAF9@2|Bacteria,1MY5U@1224|Proteobacteria,42QPW@68525|delta/epsilon subdivisions,2YP0Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S General glycosylation pathway protein - - - - - - - - - - - - - k59_846320_1 29730.Gorai.010G031500.1 6.14e-42 137.0 2E1MV@1|root,2S8Y7@2759|Eukaryota,37WT7@33090|Viridiplantae,3GKK7@35493|Streptophyta 35493|Streptophyta S One of the components of the core complex of photosystem II (PSII), required for its stability and or assembly. PSII is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation psbH - - ko:K02709 ko00195,ko01100,map00195,map01100 - - - ko00000,ko00001,ko00194 - - - PsbH k59_846320_2 4565.EPlTAEP00000010021 3.99e-23 88.2 2EFVA@1|root,2S8EW@2759|Eukaryota,37X3I@33090|Viridiplantae,3GM3E@35493|Streptophyta 35493|Streptophyta U May play a role in photosystem I and II biogenesis psbN - - ko:K02715 - - - - ko00000 - - - PsbN k59_846320_3 218851.Aquca_044_00093.1 0.0 1053.0 28JG1@1|root,2QRV6@2759|Eukaryota,37HEX@33090|Viridiplantae,3GE8P@35493|Streptophyta 35493|Streptophyta S One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light- driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation psbB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0010207,GO:0010287,GO:0015979,GO:0016020,GO:0016043,GO:0019684,GO:0022607,GO:0031976,GO:0031984,GO:0034357,GO:0034622,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0065003,GO:0071840 - ko:K02704 ko00195,ko01100,map00195,map01100 M00161 - - ko00000,ko00001,ko00002,ko00194 - - - PSII k59_878816_2 1249627.D779_3353 8.29e-41 150.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_258307_1 1249480.B649_03335 2.83e-42 152.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H ATP citrate synthase - - 2.3.3.8 ko:K15230 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,Ligase_CoA k59_522053_1 1454004.AW11_00930 1.08e-52 173.0 2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,2WC2P@28216|Betaproteobacteria,1KR2C@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_747120_1 1337936.IJ00_24095 1.22e-47 165.0 COG5634@1|root,COG5634@2|Bacteria,1G45V@1117|Cyanobacteria,1HMP8@1161|Nostocales 1117|Cyanobacteria S Uncharacterized conserved protein (DUF2278) - - - - - - - - - - - - DUF2278,LTD k59_651020_1 1408473.JHXO01000008_gene2911 5.78e-75 237.0 COG4289@1|root,COG4289@2|Bacteria,4NEU3@976|Bacteroidetes,2G2NU@200643|Bacteroidia 976|Bacteroidetes O protein conserved in bacteria - - - - - - - - - - - - DUF2264,Glyco_hydro_88 k59_586077_1 396588.Tgr7_0231 1.5e-64 202.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales 135613|Chromatiales U general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_846360_2 1502852.FG94_05163 2.13e-38 145.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VMP7@28216|Betaproteobacteria,472JZ@75682|Oxalobacteraceae 28216|Betaproteobacteria E Amino acid permease steT - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_522083_1 1167006.UWK_02851 2.14e-86 275.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner - - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_topoisoIV k59_945553_1 2340.JV46_02960 4.75e-61 198.0 COG0398@1|root,COG0607@1|root,COG0398@2|Bacteria,COG0607@2|Bacteria,1MVF3@1224|Proteobacteria,1RSK1@1236|Gammaproteobacteria 1236|Gammaproteobacteria P SNARE associated Golgi protein ydjX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Rhodanese,SNARE_assoc k59_945553_2 187272.Mlg_0751 2.98e-38 140.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1X01C@135613|Chromatiales 135613|Chromatiales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - 1.16.1.1 ko:K00520 - - - - ko00000,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_1010503_1 879212.DespoDRAFT_00375 2.55e-80 262.0 COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,42NVV@68525|delta/epsilon subdivisions,2WJIZ@28221|Deltaproteobacteria,2MIHG@213118|Desulfobacterales 28221|Deltaproteobacteria L TIGRFAM exonuclease SbcC sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SbcCD_C k59_486011_1 338966.Ppro_3708 3.83e-54 180.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_747150_1 562983.HMPREF0433_00952 1.11e-20 94.0 COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,4HCWN@91061|Bacilli,3WE98@539002|Bacillales incertae sedis 91061|Bacilli P Cation transport protein trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_846370_1 371731.Rsw2DRAFT_1361 4.04e-12 67.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TT6G@28211|Alphaproteobacteria,1FBGT@1060|Rhodobacter 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_390617_1 85643.Tmz1t_1730 1.07e-27 117.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2198@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KUIP@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_747151_1 1207075.PputUW4_04617 4.45e-119 363.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_127982_1 765910.MARPU_10625 8.32e-63 217.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_60882_1 1177154.Y5S_01949 1.12e-53 176.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1XJCE@135619|Oceanospirillales 135619|Oceanospirillales D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_1010512_1 595460.RRSWK_04882 8.43e-45 155.0 COG0631@1|root,COG0631@2|Bacteria 2|Bacteria T protein serine/threonine phosphatase activity - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_911920_2 1041142.ATTP01000026_gene5107 3.65e-09 57.4 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,4B92N@82115|Rhizobiaceae 28211|Alphaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_522102_1 1168034.FH5T_18920 9.54e-35 127.0 COG0543@1|root,COG0543@2|Bacteria,4NE35@976|Bacteroidetes,2FN69@200643|Bacteroidia 976|Bacteroidetes C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_1010513_1 1408473.JHXO01000005_gene1511 2.43e-66 209.0 COG1335@1|root,COG1335@2|Bacteria 2|Bacteria Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase,MerR_1 k59_1010513_2 1168034.FH5T_14100 5.09e-17 79.3 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase bamJ - - - - - - - - - - iSB619.SA_RS10050 Aminotran_1_2 k59_226710_1 1537917.JU82_08245 1.45e-83 260.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2YMCS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_226710_2 1209072.ALBT01000012_gene3344 9.69e-17 78.2 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RY7P@1236|Gammaproteobacteria,1FG0N@10|Cellvibrio 1236|Gammaproteobacteria J RNA 2'-O ribose methyltransferase substrate binding - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_619035_1 1260251.SPISAL_00775 1.45e-45 162.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P sulfurtransferase - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_911927_1 1219375.CM002139_gene277 1.56e-13 68.2 COG0500@1|root,COG0500@2|Bacteria,1RDHE@1224|Proteobacteria,1S3U0@1236|Gammaproteobacteria,1X6QC@135614|Xanthomonadales 135614|Xanthomonadales Q Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_911927_2 326297.Sama_3290 1.92e-44 154.0 COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,1RR21@1236|Gammaproteobacteria,2Q8NJ@267890|Shewanellaceae 1236|Gammaproteobacteria I PFAM phospholipid glycerol acyltransferase yihG - - - - - - - - - - - Acyltransferase k59_846397_1 686340.Metal_1485 2.5e-68 214.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1XEB3@135618|Methylococcales 135618|Methylococcales E subfamily IB - - - - - - - - - - - - HAD k59_357605_1 460265.Mnod_7596 6.32e-65 215.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria,1JQUY@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_554177_1 1480694.DC28_02705 6.22e-06 53.1 COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase hoxI - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - EAL,FliG_C,HATPase_c,HisKA,cNMP_binding k59_194583_1 768671.ThimaDRAFT_3845 9.65e-83 273.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WXJB@135613|Chromatiales 135613|Chromatiales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_390639_1 563040.Saut_0551 4.33e-133 396.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2YMUE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_684575_1 1168034.FH5T_17230 4.28e-94 291.0 COG0129@1|root,COG0129@2|Bacteria,4NFHP@976|Bacteroidetes,2FMCC@200643|Bacteroidia 976|Bacteroidetes EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1010525_1 1232410.KI421424_gene1830 3.49e-29 106.0 2BIZB@1|root,32D7T@2|Bacteria,1Q9TV@1224|Proteobacteria,431GP@68525|delta/epsilon subdivisions,2WWKI@28221|Deltaproteobacteria,43VCZ@69541|Desulfuromonadales 28221|Deltaproteobacteria S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_258327_1 580331.Thit_1739 1.04e-101 308.0 COG4225@1|root,COG4225@2|Bacteria,1TRJ7@1239|Firmicutes,24806@186801|Clostridia,42I40@68295|Thermoanaerobacterales 186801|Clostridia S PFAM glycosyl hydrolase family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_258327_2 1370125.AUWT01000033_gene1226 1.75e-08 60.8 COG1802@1|root,COG1802@2|Bacteria,2GMI2@201174|Actinobacteria,2374X@1762|Mycobacteriaceae 201174|Actinobacteria K FCD - - - - - - - - - - - - FCD,GntR k59_258327_3 1033810.HLPCO_002474 1.13e-56 201.0 COG0534@1|root,COG0534@2|Bacteria,2NR89@2323|unclassified Bacteria 2|Bacteria V MatE - - - - - - - - - - - - MatE k59_258327_4 1319815.HMPREF0202_00812 2.06e-189 535.0 COG3842@1|root,COG3842@2|Bacteria,3788D@32066|Fusobacteria 32066|Fusobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_623360_1 583355.Caka_1597 1.24e-96 293.0 COG0668@1|root,COG0668@2|Bacteria,46UFI@74201|Verrucomicrobia,3K8BZ@414999|Opitutae 414999|Opitutae M mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_492610_1 331678.Cphamn1_0514 1.06e-96 314.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - HemolysinCabind k59_1668_2 1254432.SCE1572_04150 2.95e-11 62.4 COG1670@1|root,COG1670@2|Bacteria,1RKT9@1224|Proteobacteria,42VCK@68525|delta/epsilon subdivisions,2WS7R@28221|Deltaproteobacteria,2Z14V@29|Myxococcales 28221|Deltaproteobacteria J Acetyltransferase (GNAT) domain rimJ2 - - ko:K03817 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_263506_1 314345.SPV1_00642 6.62e-21 96.3 COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria 1224|Proteobacteria P phosphate-selective porin O and P - - - - - - - - - - - - - k59_525377_1 1165841.SULAR_04858 1.51e-74 243.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,42RCJ@68525|delta/epsilon subdivisions,2YNX9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA k59_950326_2 1163409.UUA_01941 1.03e-32 130.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1X503@135614|Xanthomonadales 135614|Xanthomonadales M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_329346_1 1049564.TevJSym_ax00030 4.39e-78 248.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1J4K9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase phoR GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_165850_1 1172190.M947_08020 1.7e-38 142.0 COG0840@1|root,COG0840@2|Bacteria,1R486@1224|Proteobacteria,42Q5Y@68525|delta/epsilon subdivisions,2YT16@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein - - - - - - - - - - - - CZB,MCPsignal k59_165850_2 709032.Sulku_0114 3.01e-101 299.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2YNGY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_525383_1 387093.SUN_0485 1.61e-23 97.8 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2YMY9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU twitching motility protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_525383_2 387093.SUN_0487 1.41e-37 128.0 COG0721@1|root,COG0721@2|Bacteria,1Q61J@1224|Proteobacteria,42VIQ@68525|delta/epsilon subdivisions,2YQAY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_917789_1 582744.Msip34_2585 7.12e-46 159.0 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2VJ27@28216|Betaproteobacteria,2KMMS@206350|Nitrosomonadales 206350|Nitrosomonadales S VIT family - - - - - - - - - - - - VIT1 k59_67491_1 742725.HMPREF9450_00726 1.76e-46 171.0 COG3250@1|root,COG3250@2|Bacteria,4NIBS@976|Bacteroidetes,2FPZ2@200643|Bacteroidia 976|Bacteroidetes G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_67491_2 1121887.AUDK01000001_gene670 5.97e-35 129.0 COG1609@1|root,COG1609@2|Bacteria,4NDW6@976|Bacteroidetes,1HY65@117743|Flavobacteriia,2NYT0@237|Flavobacterium 976|Bacteroidetes K Periplasmic binding proteins and sugar binding domain of LacI family - - - ko:K02529,ko:K05499 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k59_34592_1 1168034.FH5T_04900 1.02e-79 251.0 COG0726@1|root,COG0726@2|Bacteria,4NF79@976|Bacteroidetes,2FR2H@200643|Bacteroidia 976|Bacteroidetes G polysaccharide deacetylase - - - - - - - - - - - - - k59_786736_1 1049564.TevJSym_ak00410 1.66e-69 214.0 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,1J62H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_165860_1 880526.KE386488_gene24 5.45e-67 214.0 COG0502@1|root,COG0502@2|Bacteria,4NI8V@976|Bacteroidetes,2FQC9@200643|Bacteroidia,22UFB@171550|Rikenellaceae 976|Bacteroidetes C Biotin and Thiamin Synthesis associated domain hydE - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_362062_1 1121918.ARWE01000001_gene350 2.33e-91 286.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,43SU0@69541|Desulfuromonadales 28221|Deltaproteobacteria H thiamine pyrophosphate protein TPP binding domain protein - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_67503_1 1537917.JU82_01895 1.7e-15 74.7 COG2857@1|root,COG2857@2|Bacteria,1PX4N@1224|Proteobacteria,42MFF@68525|delta/epsilon subdivisions,2YMBA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C ubiquinol cytochrome c oxidoreductase, cytochrome c1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - iIT341.HP1538 Cytochrom_C,Cytochrom_C1 k59_100367_1 1454004.AW11_03648 1.24e-49 171.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,1KR7P@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function DUF21 - - - - - - - - - - - - CorC_HlyC,DUF21 k59_492643_2 338963.Pcar_2643 4.13e-27 106.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase IS200 like - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_917803_1 1123325.JHUV01000011_gene1403 7.65e-20 94.7 COG1373@1|root,COG1373@2|Bacteria,2G4ED@200783|Aquificae 200783|Aquificae S AAA domain - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_165873_1 472759.Nhal_0168 3.78e-95 304.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WVXM@135613|Chromatiales 135613|Chromatiales P heavy metal translocating P-type ATPase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_950352_1 987059.RBXJA2T_03001 3.17e-93 291.0 COG1160@1|root,COG1160@2|Bacteria,1QU8G@1224|Proteobacteria,2WGIU@28216|Betaproteobacteria,1KJ6T@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Domain of unknown function (DUF3482) - - - - - - - - - - - - DUF3482,MMR_HSR1 k59_917808_1 1246626.BleG1_3892 1.87e-22 98.6 COG1307@1|root,COG1307@2|Bacteria,1TRZ4@1239|Firmicutes,4HBR8@91061|Bacilli,1ZCJP@1386|Bacillus 91061|Bacilli S protein conserved in bacteria degV - - - - - - - - - - - DegV k59_460129_1 765910.MARPU_14315 1.57e-74 238.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales 135613|Chromatiales C PFAM FAD linked oxidase domain protein - - 1.1.5.12 ko:K03777 ko00620,ko01120,map00620,map01120 - R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_917812_1 944547.ABLL_0009 1.88e-80 251.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42NSY@68525|delta/epsilon subdivisions,2YNJN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP - - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_34616_1 1415774.U728_346 1.48e-11 63.9 COG0582@1|root,COG0582@2|Bacteria,1V2RX@1239|Firmicutes,24DD0@186801|Clostridia,36J61@31979|Clostridiaceae 186801|Clostridia L integrase family - - - - - - - - - - - - Phage_integrase k59_34617_1 1415778.JQMM01000001_gene2176 2.41e-45 150.0 COG0355@1|root,COG0355@2|Bacteria,1N1NE@1224|Proteobacteria,1S9B5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C epsilon subunit - - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_34617_2 1131553.JIBI01000039_gene1938 1.65e-18 78.6 2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria,2W4TA@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_525402_1 448385.sce7726 9.35e-40 147.0 2DB92@1|root,2Z7UD@2|Bacteria,1P1QQ@1224|Proteobacteria 1224|Proteobacteria - - cll - - - - - - - - - - - - k59_525402_2 1033802.SSPSH_001460 2.82e-81 255.0 28MN3@1|root,2ZAXQ@2|Bacteria,1R4C0@1224|Proteobacteria,1RNXZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_525402_3 1114970.PSF113_0995 2.01e-77 248.0 28JYP@1|root,2Z9NV@2|Bacteria,1R4A0@1224|Proteobacteria,1SCCC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S RES - - - - - - - - - - - - RES k59_982845_1 438753.AZC_3232 3.08e-46 167.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,3F1QJ@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_917813_1 312284.A20C1_03776 8.15e-91 284.0 COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria 201174|Actinobacteria E decarboxylase - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC k59_656343_1 868595.Desca_0309 1.55e-54 174.0 COG5015@1|root,COG5015@2|Bacteria,1V4P5@1239|Firmicutes,25D0I@186801|Clostridia,262KN@186807|Peptococcaceae 186801|Clostridia S PFAM pyridoxamine 5'-phosphate - - - - - - - - - - - - Putative_PNPOx k59_656343_2 86416.Clopa_4725 4.02e-38 133.0 COG1846@1|root,COG1846@2|Bacteria,1VCHE@1239|Firmicutes,25CPQ@186801|Clostridia,36M4J@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_656343_3 572544.Ilyop_2850 3.93e-33 118.0 COG3976@1|root,COG3976@2|Bacteria 2|Bacteria S FMN binding - - - - - - - - - - - - FMN_bind k59_656343_4 1526927.Plano_2198 1.41e-79 246.0 COG3842@1|root,COG3842@2|Bacteria,1TS7K@1239|Firmicutes,4HA0K@91061|Bacilli,26EJV@186818|Planococcaceae 91061|Bacilli E ATPases associated with a variety of cellular activities - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran k59_656343_5 926561.KB900617_gene1390 3.13e-196 565.0 COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,24A64@186801|Clostridia,3WBEM@53433|Halanaerobiales 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_656343_6 349161.Dred_1529 3.49e-154 444.0 COG1840@1|root,COG1840@2|Bacteria,1TSKP@1239|Firmicutes,24C6N@186801|Clostridia 186801|Clostridia P Extracellular solute-binding protein futA1 - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_885099_4 572544.Ilyop_0631 4.63e-69 218.0 2EECX@1|root,33874@2|Bacteria,37C2M@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_885099_5 526218.Sterm_1090 3.97e-248 704.0 COG1164@1|root,COG1164@2|Bacteria,378MH@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_231767_1 1321774.HMPREF9108_00634 2.56e-162 488.0 COG0826@1|root,COG0826@2|Bacteria,3791B@32066|Fusobacteria 32066|Fusobacteria O Psort location Cytoplasmic, score 8.96 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 k59_231767_2 572544.Ilyop_0215 6.03e-69 213.0 COG1267@1|root,COG1267@2|Bacteria,37A2M@32066|Fusobacteria 32066|Fusobacteria I Phosphatidylglycerophosphatase A pgpA - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_231767_3 572544.Ilyop_0216 2.29e-156 453.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,378QD@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score 8.96 cinA - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_231767_4 572544.Ilyop_0217 1.27e-99 292.0 COG1396@1|root,COG3837@1|root,COG1396@2|Bacteria,COG3837@2|Bacteria,378CF@32066|Fusobacteria 32066|Fusobacteria K Helix-turn-helix domain - - - - - - - - - - - - Cupin_2,HTH_3 k59_231767_5 1000569.HMPREF1040_0899 2.42e-44 151.0 COG1778@1|root,COG1778@2|Bacteria,1V5JJ@1239|Firmicutes,4H4ID@909932|Negativicutes 909932|Negativicutes S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_231767_6 1319815.HMPREF0202_01300 0.0 1000.0 COG1307@1|root,COG1461@1|root,COG1307@2|Bacteria,COG1461@2|Bacteria,378J6@32066|Fusobacteria 32066|Fusobacteria S DAK2 domain fusion protein YloV - - - ko:K07030 - - - - ko00000 - - - Dak1_2,Dak2,DegV k59_231767_7 572544.Ilyop_0220 8.82e-26 103.0 COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria,379JW@32066|Fusobacteria 32066|Fusobacteria GT Psort location Cytoplasmic, score 8.96 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - CBS,PTS_EIIA_2 k59_722049_1 1205753.A989_12944 2.63e-36 141.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1X38Z@135614|Xanthomonadales 135614|Xanthomonadales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_591190_1 653733.Selin_0888 4.41e-15 79.7 COG0649@1|root,COG0649@2|Bacteria 2|Bacteria C NAD binding nuoD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa k59_689401_1 1123326.JFBL01000013_gene382 9.22e-30 113.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,42NGR@68525|delta/epsilon subdivisions,2YMH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_689401_2 1244083.CSUNSWCD_1078 1.2e-15 81.3 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2YMH2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_918474_2 1517682.HW49_02760 4.3e-13 69.3 COG0693@1|root,COG0693@2|Bacteria,4NQI1@976|Bacteroidetes,2G38B@200643|Bacteroidia,2320Q@171551|Porphyromonadaceae 976|Bacteroidetes S Thiamine biosynthesis protein ThiJ yajL - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_264094_1 1121921.KB898713_gene1702 5.61e-57 199.0 COG1629@1|root,COG1629@2|Bacteria,1MWTT@1224|Proteobacteria,1RRQ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_918475_1 387093.SUN_0163 4.99e-18 76.3 2AJEY@1|root,31A0Z@2|Bacteria,1Q4KX@1224|Proteobacteria,4325F@68525|delta/epsilon subdivisions,2YSRD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_918475_2 1165841.SULAR_10189 3.26e-76 231.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42RJW@68525|delta/epsilon subdivisions,2YP85@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_558827_1 584708.Apau_1935 8.83e-17 75.9 COG0102@1|root,COG0102@2|Bacteria,3TB8M@508458|Synergistetes 508458|Synergistetes J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_558827_2 290397.Adeh_3371 1.92e-53 171.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2WP7T@28221|Deltaproteobacteria,2YV9P@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_983330_1 756067.MicvaDRAFT_1691 0.000818 50.4 COG5434@1|root,COG5434@2|Bacteria,1G03H@1117|Cyanobacteria,1HDQJ@1150|Oscillatoriales 1117|Cyanobacteria M Right handed beta helix region - - - - - - - - - - - - Beta_helix,DUF1565 k59_101010_1 357809.Cphy_0493 1.73e-19 94.4 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_427576_2 102129.Lepto7375DRAFT_0843 6.15e-41 162.0 COG5659@1|root,COG5659@2|Bacteria,1GDXT@1117|Cyanobacteria 1117|Cyanobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_296964_2 1101195.Meth11DRAFT_1309 1.19e-92 285.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,2KKWV@206350|Nitrosomonadales 206350|Nitrosomonadales S Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_35188_1 203119.Cthe_2991 5.63e-60 209.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3WJYC@541000|Ruminococcaceae 186801|Clostridia C NADH flavin oxidoreductase NADH oxidase enr - 1.3.1.31 ko:K10797 ko00360,ko01120,map00360,map01120 - R02252 RC00669 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_329993_1 880073.Calab_3460 6.38e-09 56.2 COG2008@1|root,COG2008@2|Bacteria,2NP02@2323|unclassified Bacteria 2|Bacteria E Beta-eliminating lyase ltaE - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_623935_1 1123371.ATXH01000010_gene759 1.93e-70 224.0 COG0082@1|root,COG0082@2|Bacteria,2GGRE@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_133886_2 469617.FUAG_01478 1.96e-179 510.0 COG0116@1|root,COG0116@2|Bacteria,378K7@32066|Fusobacteria 32066|Fusobacteria L Putative RNA methylase family UPF0020 - - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_885111_1 1121028.ARQE01000001_gene3325 1.74e-23 101.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,2PJWC@255475|Aurantimonadaceae 28211|Alphaproteobacteria M OmpA family yiaD - - - - - - - - - - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA k59_657059_1 563040.Saut_0512 1.19e-80 240.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2YP3Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_983346_1 1165841.SULAR_04798 4.29e-111 340.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2YMHZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_166599_1 1168034.FH5T_13800 1.95e-79 258.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,2FMDB@200643|Bacteroidia 976|Bacteroidetes E homoserine dehydrogenase thrA - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_362383_1 1117319.PSPO_08394 3.66e-58 184.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,1S3QM@1236|Gammaproteobacteria,2PZP2@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0178 family yaiI - - ko:K09768 - - - - ko00000 - - - DUF188 k59_38633_23 1049564.TevJSym_au00160 0.0 899.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1J4XK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_38633_24 322710.Avin_40350 2.08e-58 182.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxin, 2Fe-2S type, ISC system fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_38633_25 1279017.AQYJ01000023_gene3134 2.87e-30 107.0 COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria,4698C@72275|Alteromonadaceae 1236|Gammaproteobacteria S Iron-sulphur cluster assembly iscX GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - - - - - - - - - - Fe-S_assembly k59_38633_26 713586.KB900536_gene925 2.6e-141 407.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_38633_27 1049564.TevJSym_ac01980 6.65e-226 630.0 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,1RRKZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_465739_2 1122604.JONR01000003_gene1388 2.53e-31 126.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X5SP@135614|Xanthomonadales 135614|Xanthomonadales T Putative diguanylate phosphodiesterase - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,PAS_3,PAS_8,PAS_9 k59_139075_1 1168034.FH5T_04175 4.84e-244 706.0 COG0085@1|root,COG0085@2|Bacteria,4NF8D@976|Bacteroidetes,2FMDI@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_139075_2 1408473.JHXO01000006_gene1416 9.43e-93 300.0 COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,2FMWR@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_563732_1 519989.ECTPHS_13223 2.29e-201 599.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_988351_1 1151116.Q7S_00135 2.7e-44 163.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,3FGE3@34037|Rahnella 1236|Gammaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f k59_531223_2 391615.ABSJ01000049_gene1559 9.78e-37 125.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_889627_1 1408473.JHXO01000002_gene3959 7.05e-82 249.0 COG2220@1|root,COG2220@2|Bacteria,4NFJ4@976|Bacteroidetes,2FNMD@200643|Bacteroidia 976|Bacteroidetes S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_236445_1 563040.Saut_0714 7.12e-23 95.9 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42PF7@68525|delta/epsilon subdivisions,2YM9X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the ParA family flhG - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,ParA k59_236445_2 1172190.M947_09750 3.19e-32 115.0 29NSE@1|root,309QF@2|Bacteria,1QT0N@1224|Proteobacteria,42TIY@68525|delta/epsilon subdivisions,2YP79@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_236445_3 709032.Sulku_0478 6.69e-119 345.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,42QQ8@68525|delta/epsilon subdivisions,2YMJ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the sigma-70 factor family fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r4 k59_661960_1 1537917.JU82_04415 6.27e-246 683.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2YMAP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_4920_1 1313304.CALK_0687 1.43e-23 99.8 COG1233@1|root,COG1233@2|Bacteria 2|Bacteria Q all-trans-retinol 13,14-reductase activity carC - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_857305_1 749222.Nitsa_0412 4.25e-47 167.0 COG4968@1|root,COG4968@2|Bacteria,1QUIY@1224|Proteobacteria,42S53@68525|delta/epsilon subdivisions,2YPC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prepilin-type N-terminal cleavage methylation domain - - - - - - - - - - - - N_methyl k59_367535_1 1168034.FH5T_17185 1.7e-135 394.0 COG2071@1|root,COG2071@2|Bacteria 2|Bacteria S gamma-glutamyl-gamma-aminobutyrate hydrolase activity puuD - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_563742_1 1038860.AXAP01000005_gene8052 6.58e-59 190.0 COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2TQSM@28211|Alphaproteobacteria,3JUQA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Serine hydrolase involved in the detoxification of formaldehyde fghA - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase k59_988364_1 1168034.FH5T_04365 4.71e-60 207.0 COG0457@1|root,COG0457@2|Bacteria,4NDTY@976|Bacteroidetes 976|Bacteroidetes C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_19,TPR_8 k59_955095_2 1168034.FH5T_10075 2.35e-64 200.0 COG1438@1|root,COG1438@2|Bacteria,4NSSS@976|Bacteroidetes,2FR3Q@200643|Bacteroidia 976|Bacteroidetes K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k59_268367_1 519989.ECTPHS_11807 1.78e-139 419.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_857309_1 270374.MELB17_08761 3.2e-53 177.0 COG4445@1|root,COG4445@2|Bacteria,1MVFE@1224|Proteobacteria,1RQ8Z@1236|Gammaproteobacteria,466MT@72275|Alteromonadaceae 1236|Gammaproteobacteria FJ COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA miaE - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_628989_1 1168034.FH5T_03865 4.58e-19 87.8 COG2352@1|root,COG2352@2|Bacteria,4NFC0@976|Bacteroidetes,2FSEF@200643|Bacteroidia 976|Bacteroidetes C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_628989_2 1121904.ARBP01000030_gene1942 1.35e-30 118.0 COG0628@1|root,COG0628@2|Bacteria,4NN3B@976|Bacteroidetes,47UN9@768503|Cytophagia 976|Bacteroidetes S Pfam:UPF0118 - - - - - - - - - - - - AI-2E_transport k59_139101_1 292415.Tbd_2473 1.15e-80 256.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria,1KRQV@119069|Hydrogenophilales 119069|Hydrogenophilales H CobB/CobQ-like glutamine amidotransferase domain - - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,GATase_3 k59_301188_1 572544.Ilyop_0620 4.89e-102 303.0 COG0191@1|root,COG0191@2|Bacteria,378U7@32066|Fusobacteria 32066|Fusobacteria G Fructose-1,6-bisphosphate aldolase, class II fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_106403_1 321332.CYB_1424 1.1e-06 51.6 COG1232@1|root,COG1232@2|Bacteria,1G38A@1117|Cyanobacteria,1GZ2R@1129|Synechococcus 1117|Cyanobacteria H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemG - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_694140_1 1347342.BN863_17060 1.92e-25 108.0 COG4461@1|root,COG4461@2|Bacteria,4NIBZ@976|Bacteroidetes,1I0CW@117743|Flavobacteriia 976|Bacteroidetes G 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - - - - - - - - - - PliI k59_791060_1 879212.DespoDRAFT_02520 4.05e-77 244.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - - - - - - - - - - - GIIM,RVT_1 k59_268372_1 629265.PMA4326_25967 1.04e-96 289.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1Z8UE@136849|Pseudomonas syringae group 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran k59_268372_2 2340.JV46_16300 7.88e-23 90.1 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1J6I8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein conserved in bacteria - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - DUF971 k59_171452_1 391596.PBAL39_18639 5.9e-10 65.5 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1J0HW@117747|Sphingobacteriia 976|Bacteroidetes P Probably involved in nutrient binding - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_4936_1 1340493.JNIF01000003_gene4266 2.67e-12 70.5 COG0627@1|root,COG0627@2|Bacteria,3Y3US@57723|Acidobacteria 57723|Acidobacteria S Putative esterase - - - ko:K07214 - - - - ko00000 - - - CBM_48,Esterase k59_399844_1 983545.Glaag_1580 3.8e-65 210.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,469JA@72275|Alteromonadaceae 1236|Gammaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_431896_1 1265505.ATUG01000001_gene3026 1.32e-125 397.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_759037_1 335543.Sfum_2143 5.74e-25 102.0 COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42YQS@68525|delta/epsilon subdivisions,2WUCI@28221|Deltaproteobacteria,2MRS1@213462|Syntrophobacterales 28221|Deltaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_399847_1 1116472.MGMO_7c00140 4.07e-64 201.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1XEBI@135618|Methylococcales 135618|Methylococcales S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_955120_1 1121935.AQXX01000116_gene5216 4.23e-69 222.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,1XIS5@135619|Oceanospirillales 135619|Oceanospirillales C alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_4944_1 1121875.KB907553_gene20 3.07e-68 221.0 COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_106426_1 580332.Slit_2928 7.2e-77 236.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,44VA6@713636|Nitrosomonadales 28216|Betaproteobacteria L Endonuclease/Exonuclease/phosphatase family xthA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_106426_2 1121921.KB898706_gene3291 1.04e-31 123.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,2PN23@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E Peptidase family M3 prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_203846_1 1480694.DC28_12055 1.39e-153 440.0 COG0205@1|root,COG0205@2|Bacteria,2J5F8@203691|Spirochaetes 203691|Spirochaetes F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_203846_3 768670.Calni_1697 3.66e-16 72.0 COG0607@1|root,311PP@2|Bacteria,2GG27@200930|Deferribacteres 200930|Deferribacteres P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_203846_4 47763.JNZA01000023_gene2940 4.19e-05 48.5 COG1846@1|root,COG1846@2|Bacteria,2IMA9@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator ohrR - - - - - - - - - - - MarR k59_661998_1 1168034.FH5T_11885 3.12e-131 394.0 COG0768@1|root,COG0768@2|Bacteria,4NERV@976|Bacteroidetes,2FM0U@200643|Bacteroidia 976|Bacteroidetes M Penicillin-binding protein, transpeptidase domain protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_955124_1 760117.JN27_07615 1.16e-49 179.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2VJ1D@28216|Betaproteobacteria,4724C@75682|Oxalobacteraceae 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_923492_1 1117319.PSPO_12457 8.29e-50 164.0 COG2303@1|root,COG2303@2|Bacteria,1RH5U@1224|Proteobacteria,1S60X@1236|Gammaproteobacteria,2Q2WF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - - k59_595978_1 1027273.GZ77_12555 1.48e-57 186.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1XI77@135619|Oceanospirillales 135619|Oceanospirillales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_923494_1 1265505.ATUG01000002_gene2392 5.43e-43 142.0 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Cysteine-rich - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 k59_923494_2 933262.AXAM01000001_gene343 2.81e-16 77.4 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MIGI@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM molybdopterin oxidoreductase - - 1.17.1.10,1.17.1.9 ko:K00123,ko:K05299 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_759052_1 1321774.HMPREF9108_00929 1.37e-22 96.7 COG1132@1|root,COG1132@2|Bacteria,379H4@32066|Fusobacteria 32066|Fusobacteria V K11085 ATP-binding cassette, subfamily B, bacterial MsbA - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_759052_2 572544.Ilyop_1109 9.3e-89 266.0 COG0689@1|root,COG0689@2|Bacteria,3794V@32066|Fusobacteria 32066|Fusobacteria J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - Ham1p_like,RNase_PH,RNase_PH_C k59_268397_1 519989.ECTPHS_01684 4e-111 326.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1WW0D@135613|Chromatiales 135613|Chromatiales S PFAM ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_4951_1 926690.KE386573_gene328 2.27e-17 85.1 COG2025@1|root,arCOG00447@2157|Archaea,2XT06@28890|Euryarchaeota,23T9I@183963|Halobacteria 183963|Halobacteria C Electron transfer flavoprotein alpha subunit etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_236505_1 926550.CLDAP_35110 1.69e-39 143.0 COG0205@1|root,COG0205@2|Bacteria,2G6CJ@200795|Chloroflexi 200795|Chloroflexi F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_759056_1 983545.Glaag_2288 2.97e-65 212.0 COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,1RZ9J@1236|Gammaproteobacteria,4651I@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Esterase PHB depolymerase - - - - - - - - - - - - Esterase,Esterase_phd k59_39234_1 1168034.FH5T_06360 1.12e-143 409.0 COG1484@1|root,COG1484@2|Bacteria,4NFE0@976|Bacteroidetes,2FPQ9@200643|Bacteroidia 976|Bacteroidetes L COG1484 DNA replication protein - - - - - - - - - - - - IstB_IS21 k59_39234_2 1168034.FH5T_03775 2.46e-268 746.0 COG4565@1|root,COG4584@1|root,COG4565@2|Bacteria,COG4584@2|Bacteria,4NEY6@976|Bacteroidetes,2FMHY@200643|Bacteroidia 976|Bacteroidetes L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_11,HTH_23,rve k59_203866_1 385682.AFSL01000012_gene2839 3.02e-36 140.0 COG1874@1|root,COG1874@2|Bacteria,4NE2P@976|Bacteroidetes,2G1DQ@200643|Bacteroidia,3XKX6@558415|Marinilabiliaceae 976|Bacteroidetes G Glycosyl hydrolases family 35 - - - - - - - - - - - - Glyco_hydro_35 k59_563803_1 1121920.AUAU01000004_gene855 9.73e-33 118.0 COG0066@1|root,COG0066@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_563803_2 1121920.AUAU01000004_gene856 1.08e-35 132.0 COG0065@1|root,COG0065@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity hacA - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_236510_2 306263.Cla_0737 5.32e-42 156.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2YMM3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin biosynthesis moeA1 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_694192_1 1168034.FH5T_05695 5.07e-225 628.0 COG1262@1|root,COG1262@2|Bacteria,4NE51@976|Bacteroidetes,2FQNC@200643|Bacteroidia 976|Bacteroidetes S Sulfatase-modifying factor enzyme 1 gldJ - - - - - - - - - - - FGE-sulfatase k59_139169_1 335543.Sfum_3869 2.17e-77 242.0 COG1801@1|root,COG1801@2|Bacteria,1MXIQ@1224|Proteobacteria,42XHB@68525|delta/epsilon subdivisions,2WSKY@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_759074_1 1121378.KB899757_gene3244 3.54e-32 132.0 COG2909@1|root,COG2909@2|Bacteria 2|Bacteria K trisaccharide binding - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE k59_335353_1 1165841.SULAR_04868 5.83e-78 248.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2YNJR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P potassium channel protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2,TrkA_C,TrkA_N k59_139173_2 1223521.BBJX01000004_gene2596 2.84e-17 81.6 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2VJIT@28216|Betaproteobacteria,4AC6D@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22,2.6.1.76 ko:K00823,ko:K00836,ko:K07250 ko00250,ko00260,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00280,map00410,map00640,map00650,map01100,map01120,map01210,map01230 M00027,M00033 R00908,R01648,R04188,R06977 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_662031_1 1538295.JY96_00505 1.51e-17 80.1 COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,2VQ90@28216|Betaproteobacteria,1KN3F@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_662031_2 2342.SOPEG_3463 3.52e-34 127.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases qor2 - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_694201_1 1121405.dsmv_2488 1.13e-79 249.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,42NN3@68525|delta/epsilon subdivisions,2WJZP@28221|Deltaproteobacteria,2MJAW@213118|Desulfobacterales 28221|Deltaproteobacteria P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_629068_1 396588.Tgr7_0509 4.86e-86 267.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1WZ40@135613|Chromatiales 135613|Chromatiales J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_988458_1 1479235.KK366039_gene2724 1.34e-63 204.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1XHIU@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_988458_2 314275.MADE_000001021065 1.66e-49 160.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,466X0@72275|Alteromonadaceae 1236|Gammaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_39257_1 457424.BFAG_03975 2.21e-09 61.2 COG1887@1|root,COG1887@2|Bacteria,4P4D1@976|Bacteroidetes,2FVH3@200643|Bacteroidia,4ASNZ@815|Bacteroidaceae 976|Bacteroidetes M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - - - - - - - - - - - Glyphos_transf k59_596020_1 225849.swp_0022 1.8e-28 107.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,1S25K@1236|Gammaproteobacteria,2QA5S@267890|Shewanellaceae 1236|Gammaproteobacteria L TIGRFAM DNA-3-methyladenine glycosylase I tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_237002_1 1168034.FH5T_08535 1.45e-104 325.0 COG1554@1|root,COG1554@2|Bacteria,4NFG1@976|Bacteroidetes,2FME6@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolase family 65 central catalytic domain - - 2.4.1.8 ko:K00691 ko00500,ko01100,map00500,map01100 - R01555 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m k59_629622_1 765913.ThidrDRAFT_0035 2.36e-174 518.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales 135613|Chromatiales U Hydrophobe Amphiphile Efflux-1 (HAE1) - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_890235_1 396588.Tgr7_0298 3.95e-71 218.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1WY42@135613|Chromatiales 135613|Chromatiales H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_890235_2 2340.JV46_02650 5.23e-46 149.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,1J6N0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain fdx1 - - - - - - - - - - - Fer4 k59_176900_2 426716.JOAJ01000001_gene535 1.9e-23 96.3 COG0454@1|root,COG0456@2|Bacteria,2IMKZ@201174|Actinobacteria,4G1Q5@85025|Nocardiaceae 201174|Actinobacteria K acid acetyltransferase ectA GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 2.3.1.178 ko:K06718 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06978 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_993765_2 351746.Pput_1607 9.05e-31 124.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1YVTU@136845|Pseudomonas putida group 1236|Gammaproteobacteria P heavy metal translocating P-type ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_8034_1 1165841.SULAR_08242 7.57e-70 231.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2YMB3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB1 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_895250_1 102125.Xen7305DRAFT_00024850 4.02e-11 71.6 COG1874@1|root,COG1874@2|Bacteria,1GH6K@1117|Cyanobacteria,3VNCP@52604|Pleurocapsales 1117|Cyanobacteria G Beta-galactosidase - - - - - - - - - - - - - k59_1025276_1 929558.SMGD1_1593 8.8e-104 325.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2YN4S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_241243_1 1249627.D779_2212 3.89e-68 222.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1WWAI@135613|Chromatiales 135613|Chromatiales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_794225_1 1049564.TevJSym_ap00550 2.26e-32 121.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1J5UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_794225_2 937774.TEQUI_1050 9.63e-29 123.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,3T1EQ@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the transfer of electrons from NADH to ubiquinone nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_469896_1 1137799.GZ78_10145 1.55e-13 76.3 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1XJ0T@135619|Oceanospirillales 135619|Oceanospirillales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_730756_2 572544.Ilyop_0857 7.62e-128 370.0 COG0561@1|root,COG0561@2|Bacteria,378P3@32066|Fusobacteria 32066|Fusobacteria S PFAM Haloacid dehalogenase domain protein hydrolase type 3 - - - - - - - - - - - - Hydrolase_3 k59_730756_3 1536775.H70737_29375 3.63e-165 469.0 COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,4HAPJ@91061|Bacilli,26TSR@186822|Paenibacillaceae 91061|Bacilli S Dehydrogenase - - - - - - - - - - - - GFO_IDH_MocA k59_730756_4 552396.HMPREF0863_02122 7.34e-70 220.0 COG0120@1|root,COG0120@2|Bacteria,1V22S@1239|Firmicutes,3VQQA@526524|Erysipelotrichia 526524|Erysipelotrichia G Ribose 5-phosphate isomerase rpiA - - - - - - - - - - - Rib_5-P_isom_A k59_730756_5 545243.BAEV01000122_gene3060 3.31e-147 421.0 COG1737@1|root,COG1737@2|Bacteria,1UYAM@1239|Firmicutes,25CE5@186801|Clostridia,36WUD@31979|Clostridiaceae 186801|Clostridia K transcriptional regulator, RpiR family - - - - - - - - - - - - HTH_6,SIS k59_895253_1 948106.AWZT01000016_gene202 1.05e-210 591.0 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2VJ1V@28216|Betaproteobacteria,1K0UD@119060|Burkholderiaceae 28216|Betaproteobacteria C nitrate reductase beta subunit narH - 1.7.5.1 ko:K00371,ko:K17051 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Fer4_11,Nitr_red_bet_C k59_895253_2 1123255.JHYS01000001_gene2024 2.16e-27 110.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,4A9MX@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narG - 1.7.5.1 ko:K00370,ko:K17050 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_699035_1 1286093.C266_00235 1.64e-37 130.0 COG2076@1|root,COG2076@2|Bacteria,1NAUF@1224|Proteobacteria,2WE9Q@28216|Betaproteobacteria,1KHNZ@119060|Burkholderiaceae 28216|Betaproteobacteria P Small Multidrug Resistance protein - - - - - - - - - - - - EamA,Multi_Drug_Res k59_699035_2 701347.Entcl_0247 1.95e-09 58.9 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,3X1ME@547|Enterobacter 1236|Gammaproteobacteria M Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides arnB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:0099620,GO:1901363 2.6.1.87 ko:K07806 ko00520,ko01503,ko02020,map00520,map01503,map02020 M00721,M00761 R07659 RC00006,RC01514 ko00000,ko00001,ko00002,ko01000,ko01005,ko01007 - - iSFxv_1172.SFxv_2574 DegT_DnrJ_EryC1 k59_78066_1 387093.SUN_1128 7.81e-128 382.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2YMYX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g,tRNA_bind k59_568737_1 1094980.Mpsy_2980 8.07e-47 169.0 COG0745@1|root,COG0784@1|root,COG2203@1|root,arCOG02348@1|root,arCOG02352@1|root,arCOG02360@1|root,arCOG02376@1|root,arCOG04001@1|root,arCOG02348@2157|Archaea,arCOG02352@2157|Archaea,arCOG02357@2157|Archaea,arCOG02360@2157|Archaea,arCOG02376@2157|Archaea,arCOG02591@2157|Archaea,arCOG02595@2157|Archaea,arCOG04001@2157|Archaea,2Y82D@28890|Euryarchaeota,2NBNN@224756|Methanomicrobia 2157|Archaea T Histidine Phosphotransfer domain - - 2.7.7.65 ko:K02488,ko:K11443 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - BAT,GAF,GAF_2,GAF_3,HATPase_c,HTH_10,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_110951_1 76114.ebA5705 7.74e-24 103.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,2KVK9@206389|Rhodocyclales 206389|Rhodocyclales IQ Phosphate acyltransferases - - - - - - - - - - - - AMP-binding,Acyltransferase,PP-binding k59_1025297_1 1415778.JQMM01000001_gene1715 2.63e-24 102.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1J6DG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Involved in DNA repair and RecF pathway recombination recO GO:0008150,GO:0009314,GO:0009628,GO:0050896 - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_601596_1 716544.wcw_0174 9.15e-24 108.0 COG3209@1|root,COG3209@2|Bacteria,2JFH5@204428|Chlamydiae 204428|Chlamydiae M Rhs family rhs1 - - - - - - - - - - - DUF687,RHS_repeat k59_601596_3 1254432.SCE1572_33850 3.58e-15 75.9 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Rhs family - - - - - - - - - - - - AHH,RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_372479_1 1105367.CG50_06515 2e-56 193.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_372479_2 1353528.DT23_05825 4.17e-08 53.5 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,2XKP5@285107|Thioclava 28211|Alphaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_8049_1 1168034.FH5T_11910 3.96e-102 306.0 COG0707@1|root,COG0707@2|Bacteria,4NE6D@976|Bacteroidetes,2FMND@200643|Bacteroidia 976|Bacteroidetes M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_8049_2 1168034.FH5T_11915 3.28e-38 139.0 COG0773@1|root,COG0773@2|Bacteria,4NE1V@976|Bacteroidetes,2FM6G@200643|Bacteroidia 976|Bacteroidetes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1025302_1 398512.JQKC01000001_gene2496 0.000134 49.7 COG5337@1|root,COG5337@2|Bacteria,1U0PJ@1239|Firmicutes,24Z89@186801|Clostridia,3WMZK@541000|Ruminococcaceae 186801|Clostridia M CotH kinase protein - - - - - - - - - - - - CotH,Dockerin_1 k59_340828_1 1122185.N792_01060 5.14e-37 131.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1X4H1@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_340828_2 765910.MARPU_16705 1.58e-27 102.0 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,1S61Y@1236|Gammaproteobacteria,1WZ34@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0250 family - - - ko:K09158 - - - - ko00000 - - - DUF493 k59_993794_1 1121912.AUHD01000008_gene201 2.57e-23 94.4 COG0594@1|root,COG0594@2|Bacteria,4NUMM@976|Bacteroidetes,1I41Y@117743|Flavobacteriia 976|Bacteroidetes J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_993794_2 1168034.FH5T_06510 7.89e-163 457.0 COG1587@1|root,COG1587@2|Bacteria,4NEQ3@976|Bacteroidetes,2FMX9@200643|Bacteroidia 976|Bacteroidetes H Uroporphyrinogen-III synthase hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_568746_1 1168034.FH5T_01580 9.06e-97 292.0 COG1520@1|root,COG1520@2|Bacteria,4P0ZC@976|Bacteroidetes,2FW9F@200643|Bacteroidia 976|Bacteroidetes S PQQ-like domain - - - - - - - - - - - - PQQ_2 k59_504225_1 1459636.NTE_00485 3.76e-27 117.0 arCOG10869@1|root,arCOG10869@2157|Archaea 2157|Archaea S Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157 k59_78085_1 296591.Bpro_0761 3.6e-53 182.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,4ACHN@80864|Comamonadaceae 28216|Betaproteobacteria I AMP-binding enzyme C-terminal domain - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1025303_1 1227739.Hsw_3750 3.62e-20 99.8 COG5492@1|root,COG5492@2|Bacteria,4NH7Q@976|Bacteroidetes,47MBP@768503|Cytophagia 976|Bacteroidetes N domain, Protein - - - - - - - - - - - - TIG k59_241278_1 1267533.KB906742_gene675 2.23e-13 76.3 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria 57723|Acidobacteria K Tetratricopeptide repeat - - - - - - - - - - - - - k59_667306_1 1120970.AUBZ01000082_gene2710 5.99e-16 69.7 2E4EA@1|root,32Z9I@2|Bacteria,1N7HE@1224|Proteobacteria,1SDU5@1236|Gammaproteobacteria,46BUS@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_601606_1 880070.Cycma_1529 4.58e-114 338.0 COG1680@1|root,COG1680@2|Bacteria,4NGND@976|Bacteroidetes 976|Bacteroidetes V Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase k59_601606_2 1168034.FH5T_14125 3.29e-65 201.0 COG0691@1|root,COG0691@2|Bacteria,4NNJU@976|Bacteroidetes,2FQX0@200643|Bacteroidia 976|Bacteroidetes O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_272758_1 396588.Tgr7_2124 2.53e-19 92.8 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales 135613|Chromatiales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5,3.6.4.12 ko:K03582,ko:K16898 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1025306_1 768671.ThimaDRAFT_0549 1.29e-101 313.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1WX2Y@135613|Chromatiales 135613|Chromatiales I synthetase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_436773_1 795359.TOPB45_1414 6.33e-36 137.0 COG1154@1|root,COG1154@2|Bacteria,2GH58@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria HI Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_436773_2 1410630.JNKP01000003_gene1204 2.31e-05 45.8 COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia,27IPP@186928|unclassified Lachnospiraceae 186801|Clostridia J FtsJ-like methyltransferase rrmJ - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_667308_1 1172562.HCN_0934 9.67e-05 43.9 COG0731@1|root,COG0731@2|Bacteria,1QG36@1224|Proteobacteria,42M82@68525|delta/epsilon subdivisions,2YN42@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM k59_241280_1 518766.Rmar_1542 1.8e-86 286.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,1FJ5H@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_536561_1 396588.Tgr7_2146 1.74e-235 660.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_1025309_1 1385520.N802_05375 2.85e-45 163.0 COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4FG60@85021|Intrasporangiaceae 201174|Actinobacteria E gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_667959_1 1125699.HMPREF9194_01498 4.31e-06 48.9 COG0495@1|root,COG0495@2|Bacteria,2J5BV@203691|Spirochaetes 203691|Spirochaetes J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_667959_2 96561.Dole_2437 1.39e-18 85.1 COG2980@1|root,COG2980@2|Bacteria,1NIUQ@1224|Proteobacteria,42XGJ@68525|delta/epsilon subdivisions,2WSS7@28221|Deltaproteobacteria,2MKPB@213118|Desulfobacterales 28221|Deltaproteobacteria M Lipopolysaccharide-assembly lptE - - - - - - - - - - - LptE k59_764740_1 1232437.KL662061_gene4206 8.08e-104 317.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2WJZA@28221|Deltaproteobacteria,2MJXH@213118|Desulfobacterales 28221|Deltaproteobacteria P Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_373035_1 1249480.B649_10680 9.58e-222 629.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2YMB2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_373035_2 1537917.JU82_01655 5.22e-95 278.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,42QR7@68525|delta/epsilon subdivisions,2YNZC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_8449_1 1049564.TevJSym_ac00090 5.08e-136 398.0 COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,1RQ8F@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Nitrous oxidase accessory protein nosD - - ko:K07218 - - - - ko00000 - - - NosD k59_731340_2 1123401.JHYQ01000012_gene2825 6.6e-73 233.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,45ZQ5@72273|Thiotrichales 72273|Thiotrichales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_111500_1 1121396.KB893097_gene4342 9.5e-124 368.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MI7X@213118|Desulfobacterales 28221|Deltaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_405200_1 870187.Thini_2168 6.04e-123 365.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Iron-sulfur cluster binding protein lutB - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_764750_1 880072.Desac_2506 8.79e-102 327.0 COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,42N7J@68525|delta/epsilon subdivisions,2WKRJ@28221|Deltaproteobacteria,2MQ4J@213462|Syntrophobacterales 28221|Deltaproteobacteria H PFAM CobN magnesium chelatase - - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel k59_961081_1 717774.Marme_2229 4.4e-170 494.0 2B1Z8@1|root,31UFT@2|Bacteria,1RHY7@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - TIR_2 k59_994382_1 1168034.FH5T_07275 7.69e-33 120.0 28H74@1|root,2Z7JF@2|Bacteria,4NFR0@976|Bacteroidetes,2FQ0B@200643|Bacteroidia 976|Bacteroidetes S Gliding motility-associated protein GldN gldN - - - - - - - - - - - - k59_994382_2 1168034.FH5T_07270 6.51e-30 117.0 COG1262@1|root,COG1262@2|Bacteria,4NGY2@976|Bacteroidetes,2FPTN@200643|Bacteroidia 976|Bacteroidetes M gliding motility-associated lipoprotein GldK gldK - - - - - - - - - - - FGE-sulfatase k59_405206_1 933262.AXAM01000056_gene3169 2.14e-62 205.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,42R96@68525|delta/epsilon subdivisions,2WMVV@28221|Deltaproteobacteria,2MHT9@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_341471_1 1046627.BZARG_1776 2.9e-49 159.0 COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,1I2XY@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_341471_2 357804.Ping_1904 6.47e-07 49.7 COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1SGF3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_241906_1 396588.Tgr7_2114 1.23e-39 150.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_699695_1 264462.Bd3790 0.000699 46.6 COG0484@1|root,COG1426@1|root,COG0484@2|Bacteria,COG1426@2|Bacteria,1NCYU@1224|Proteobacteria,42WS1@68525|delta/epsilon subdivisions,2MT9U@213481|Bdellovibrionales,2WSDX@28221|Deltaproteobacteria 213481|Bdellovibrionales O Helix-turn-helix domain - - - - - - - - - - - - DnaJ,HTH_25 k59_78667_1 234267.Acid_4208 2.6e-30 116.0 COG1913@1|root,COG1913@2|Bacteria,3Y880@57723|Acidobacteria 57723|Acidobacteria S Peptidase family M54 - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 k59_634898_1 1210884.HG799468_gene13805 4.46e-11 70.1 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IZGV@203682|Planctomycetes 1210884.HG799468_gene13805|- KLT Protein tyrosine kinase - - - - - - - - - - - - - k59_470454_3 1173021.ALWA01000028_gene2042 6.69e-10 59.7 COG0525@1|root,COG0525@2|Bacteria,1G14J@1117|Cyanobacteria 1117|Cyanobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,CAAD,Val_tRNA-synt_C,tRNA-synt_1 k59_731361_1 572544.Ilyop_0582 7.59e-25 99.4 COG3086@1|root,COG3086@2|Bacteria,379UH@32066|Fusobacteria 32066|Fusobacteria T Positive regulator of sigma(E), RseC/MucC - - - ko:K03803 - - - - ko00000,ko03021 - - - RseC_MucC k59_731361_2 768706.Desor_2727 3.91e-30 115.0 COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,248C8@186801|Clostridia,265H8@186807|Peptococcaceae 186801|Clostridia S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_273322_1 1115632.JAFW01000001_gene1286 3.4e-38 147.0 COG0642@1|root,COG0642@2|Bacteria,2I58H@201174|Actinobacteria 201174|Actinobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_470456_1 1165841.SULAR_07795 6.36e-84 264.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42MYT@68525|delta/epsilon subdivisions,2YMKP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_896033_1 1265313.HRUBRA_01492 2.03e-40 142.0 COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_929272_1 1408224.SAMCCGM7_c6033 5.22e-58 203.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4B8QC@82115|Rhizobiaceae 28211|Alphaproteobacteria V efflux pump - - - - - - - - - - - - ACR_tran k59_994398_1 349124.Hhal_1657 1.59e-59 207.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_667999_1 1484460.JSWG01000009_gene157 6.58e-82 270.0 COG1196@1|root,COG1196@2|Bacteria,4NF7P@976|Bacteroidetes,1HYD4@117743|Flavobacteriia 976|Bacteroidetes D ATPase involved in DNA repair - - - - - - - - - - - - DUF4175 k59_667999_2 313603.FB2170_05910 7.99e-10 59.3 COG3239@1|root,COG3239@2|Bacteria,4NIC2@976|Bacteroidetes,1HYBV@117743|Flavobacteriia 976|Bacteroidetes I Fatty acid desaturase alkB - 1.14.15.3 ko:K00496 ko00071,ko00930,map00071,map00930 - R01347,R02281,R06945 RC00478 ko00000,ko00001,ko01000 - - - FA_desaturase k59_731365_2 749222.Nitsa_0694 2.95e-141 410.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2YN6C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidase U32 family prtC - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_929274_1 1168034.FH5T_20565 5.1e-149 454.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_277754_1 907931.AEIZ01000013_gene810 2.85e-18 83.6 COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H9R3@91061|Bacilli,4AX5R@81850|Leuconostocaceae 91061|Bacilli F Belongs to the phosphoglycerate kinase family pgk GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSB619.SA_RS04145 PGK k59_769632_1 187272.Mlg_0911 2.84e-84 263.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales 135613|Chromatiales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_933707_1 929558.SMGD1_0542 6.73e-126 385.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2YN0Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_441987_1 479431.Namu_4080 1.65e-100 317.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4ERQZ@85013|Frankiales 201174|Actinobacteria G pyruvate phosphate dikinase, PEP ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_672702_1 765952.PUV_26930 7.58e-07 50.8 COG0564@1|root,COG0564@2|Bacteria,2JG1U@204428|Chlamydiae 204428|Chlamydiae J RNA pseudouridylate synthase - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_672702_2 525897.Dbac_2887 3.22e-76 236.0 COG1092@1|root,COG1092@2|Bacteria,1Q08C@1224|Proteobacteria,42RRW@68525|delta/epsilon subdivisions,2WNY5@28221|Deltaproteobacteria,2MAYH@213115|Desulfovibrionales 28221|Deltaproteobacteria J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_12698_1 452637.Oter_0894 8.37e-114 362.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae 414999|Opitutae E glutamate synthase - - 1.4.7.1 ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 - R00021,R10086 RC00006,RC00010 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_475163_1 1249480.B649_11690 1.43e-217 606.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2YM81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Cysteine desulfurase iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_246590_2 1121101.HMPREF1532_01485 0.000185 48.5 COG0860@1|root,COG0860@2|Bacteria,4PPDZ@976|Bacteroidetes,2G15H@200643|Bacteroidia,4ATKG@815|Bacteroidaceae 976|Bacteroidetes M Cna protein B-type domain - - - - - - - - - - - - Amidase_3 k59_639589_1 1537917.JU82_02185 7.83e-84 258.0 COG2374@1|root,COG2374@2|Bacteria,1RCTI@1224|Proteobacteria,42Q2J@68525|delta/epsilon subdivisions,2YNG1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_182409_1 641112.ACOK01000043_gene1659 3e-17 79.7 COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,3WIM6@541000|Ruminococcaceae 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_182409_2 381764.Fnod_0126 2.86e-07 52.0 COG0268@1|root,COG0268@2|Bacteria,2GDFA@200918|Thermotogae 200918|Thermotogae J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_214967_1 1168034.FH5T_07475 1.01e-146 426.0 COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes,2FMG2@200643|Bacteroidia 976|Bacteroidetes P Arylsulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_705180_1 1125971.ASJB01000092_gene4511 2.77e-70 234.0 COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DZ2U@85010|Pseudonocardiales 201174|Actinobacteria I AMP-forming long-chain acyl-CoA synthetase - - - - - - - - - - - - AMP-binding k59_378225_1 749222.Nitsa_0618 5.82e-85 265.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2YNAD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C K transport system, NAD-binding component - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_705182_1 387093.SUN_1365 4.14e-13 69.3 COG0679@1|root,COG0679@2|Bacteria,1N5NC@1224|Proteobacteria,42PYE@68525|delta/epsilon subdivisions,2YMUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_607705_1 1168034.FH5T_18930 1.04e-74 236.0 COG0508@1|root,COG0508@2|Bacteria,4NED0@976|Bacteroidetes,2FNQF@200643|Bacteroidia 976|Bacteroidetes C COG COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes bfmBB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_607705_2 1168034.FH5T_18925 1.29e-87 265.0 COG0167@1|root,COG0167@2|Bacteria,4NDVB@976|Bacteroidetes,2FPMW@200643|Bacteroidia 976|Bacteroidetes F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14,1.3.98.1 ko:K00226,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_934382_1 572477.Alvin_1421 3.81e-55 184.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales 135613|Chromatiales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_799719_1 457412.RSAG_02014 1.48e-30 114.0 COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,3WIVU@541000|Ruminococcaceae 186801|Clostridia H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_799719_2 1122173.AXVL01000009_gene925 3.45e-129 385.0 COG0657@1|root,COG0657@2|Bacteria,3794A@32066|Fusobacteria 32066|Fusobacteria I Nicotinate phosphoribosyltransferase - - - - - - - - - - - - - k59_799719_3 1196029.ALIM01000013_gene4053 7.53e-51 177.0 COG0657@1|root,COG0657@2|Bacteria,1USHI@1239|Firmicutes,4HV7X@91061|Bacilli 91061|Bacilli I acetylesterase activity - - - - - - - - - - - - - k59_966599_1 572544.Ilyop_0965 7.89e-38 139.0 COG1233@1|root,COG1233@2|Bacteria,37BFC@32066|Fusobacteria 32066|Fusobacteria Q Flavin containing amine oxidoreductase - - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_966599_2 1286171.EAL2_c15580 1.66e-139 411.0 COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,2494Y@186801|Clostridia,25UQJ@186806|Eubacteriaceae 186801|Clostridia S ABC1 family - - - ko:K03688 - - - - ko00000 - - - ABC1 k59_966599_3 926692.AZYG01000084_gene618 1.2e-66 212.0 COG0398@1|root,COG0398@2|Bacteria,1UHVT@1239|Firmicutes,24H7Q@186801|Clostridia,3WBIQ@53433|Halanaerobiales 186801|Clostridia S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_966599_4 1095747.HMPREF1049_0834 7.21e-97 290.0 COG1951@1|root,COG1951@2|Bacteria,3798M@32066|Fusobacteria 32066|Fusobacteria C Fumarate hydratase (Fumerase) - - 4.2.1.2 ko:K01677 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase k59_705193_1 1168034.FH5T_21225 6.22e-69 225.0 COG0659@1|root,COG0659@2|Bacteria,4NF1C@976|Bacteroidetes,2FPEW@200643|Bacteroidia 976|Bacteroidetes P Sulfate permease sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_835735_1 536019.Mesop_0934 1.18e-32 124.0 2BF7S@1|root,3290C@2|Bacteria,1MYAY@1224|Proteobacteria,2U9YG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_934387_1 572544.Ilyop_0271 1.65e-64 209.0 COG1309@1|root,COG1309@2|Bacteria,3790P@32066|Fusobacteria 32066|Fusobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_378232_2 1537917.JU82_07650 1.43e-94 286.0 COG2177@1|root,COG2177@2|Bacteria,1R85B@1224|Proteobacteria,42PX3@68525|delta/epsilon subdivisions,2YNQW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Cell division protein FtsX ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - k59_378232_3 563040.Saut_0811 2.71e-121 350.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2YT9B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D ABC transporter ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_378232_4 1172190.M947_09660 1.53e-29 116.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,42M78@68525|delta/epsilon subdivisions,2YMR1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_247290_1 452662.SJA_C1-13530 1.14e-10 70.1 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1R5EH@1224|Proteobacteria,2UQHJ@28211|Alphaproteobacteria,2KDTT@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_13450_1 1123504.JQKD01000020_gene5634 6.14e-53 176.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria,4ABYS@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B_2 k59_705204_1 933262.AXAM01000058_gene3196 2.09e-52 186.0 COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MICZ@213118|Desulfobacterales 28221|Deltaproteobacteria GT pyruvate phosphate dikinase - - - - - - - - - - - - NTP_transf_2,PPDK_N k59_247295_1 1122137.AQXF01000003_gene1871 5.78e-35 134.0 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,2VFH0@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_705209_1 1227499.C493_00540 5.97e-25 108.0 COG4948@1|root,arCOG01168@2157|Archaea,2XU6X@28890|Euryarchaeota,23SAR@183963|Halobacteria 183963|Halobacteria H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_247296_1 264198.Reut_B4712 3.85e-141 416.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNB8@28216|Betaproteobacteria,1KGH9@119060|Burkholderiaceae 28216|Betaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_640290_1 160488.PP_2440 8.28e-93 286.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,1RNC7@1236|Gammaproteobacteria,1YW5P@136845|Pseudomonas putida group 1236|Gammaproteobacteria C Alkyl hydroperoxide reductase ahpF GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008785,GO:0009321,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204 - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_799725_3 1235457.C404_20655 2.71e-15 79.0 2E8HH@1|root,332VP@2|Bacteria,1NACZ@1224|Proteobacteria,2WBW2@28216|Betaproteobacteria,1KBBY@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_442695_1 756067.MicvaDRAFT_4467 1.28e-46 171.0 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_934400_1 1168067.JAGP01000001_gene86 3.01e-70 221.0 COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,1RR7M@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type phosphate phosphonate transport system periplasmic component - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_1031268_1 177437.HRM2_44680 8.65e-109 331.0 COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,42NX3@68525|delta/epsilon subdivisions,2WME4@28221|Deltaproteobacteria,2MPJH@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_410641_1 1537917.JU82_03820 2.52e-78 248.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2YNJC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_116894_1 1000565.METUNv1_03611 5.88e-09 64.3 COG2207@1|root,COG2207@2|Bacteria,1Q3UX@1224|Proteobacteria,2VT4I@28216|Betaproteobacteria,2KXSI@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_311973_1 644282.Deba_1110 9.26e-110 323.0 COG1250@1|root,COG1250@2|Bacteria,1RC1I@1224|Proteobacteria,42YJN@68525|delta/epsilon subdivisions,2WTUM@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_1031273_1 187272.Mlg_2763 1.77e-06 48.9 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1031273_2 395493.BegalDRAFT_2301 3.39e-98 299.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,45ZPY@72273|Thiotrichales 72273|Thiotrichales E Glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_116896_2 1165841.SULAR_04858 2.01e-78 253.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,42RCJ@68525|delta/epsilon subdivisions,2YNX9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA k59_799748_1 1120972.AUMH01000053_gene1764 8.24e-19 90.9 COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,4HHM8@91061|Bacilli 91061|Bacilli L PFAM Mu transposase, C-terminal - - - - - - - - - - - - Mu-transpos_C,rve k59_116900_2 394221.Mmar10_0330 2.17e-15 79.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_16,TPR_8,Trans_reg_C k59_215711_1 331678.Cphamn1_2543 1.78e-95 305.0 COG0610@1|root,COG0610@2|Bacteria 2|Bacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_640306_1 1168034.FH5T_01365 3.06e-50 175.0 COG0488@1|root,COG0488@2|Bacteria,4NG1W@976|Bacteroidetes,2FMY5@200643|Bacteroidia 976|Bacteroidetes S ABC transporter, ATP-binding protein yheS_3 - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_215715_2 1165841.SULAR_03382 1.95e-27 106.0 COG1266@1|root,COG1266@2|Bacteria,1ND7U@1224|Proteobacteria 1224|Proteobacteria S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_278546_1 945713.IALB_0544 7.25e-77 237.0 COG0755@1|root,COG0755@2|Bacteria 2|Bacteria O cytochrome complex assembly - - - - - - - - - - - - Cytochrom_C_asm k59_966649_1 387093.SUN_1193 1.18e-109 326.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2YNAC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_966649_2 553220.CAMGR0001_1465 7.55e-48 166.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42NHA@68525|delta/epsilon subdivisions,2YMYU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX1 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_442720_1 1121405.dsmv_1575 1.07e-29 109.0 COG5512@1|root,COG5512@2|Bacteria,1N6KK@1224|Proteobacteria,42TK4@68525|delta/epsilon subdivisions,2WQQS@28221|Deltaproteobacteria,2MM03@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 k59_799766_1 1168034.FH5T_17450 1.64e-25 102.0 2C8RB@1|root,32RMP@2|Bacteria,4NTVV@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_799766_2 376686.Fjoh_3148 2.95e-59 191.0 2C0BR@1|root,32RD6@2|Bacteria,4NQ5J@976|Bacteroidetes,1I397@117743|Flavobacteriia,2NVIA@237|Flavobacterium 976|Bacteroidetes S Protein of unknown function (DUF4255) - - - - - - - - - - - - DUF4255 k59_410668_1 1168034.FH5T_04750 8.79e-100 296.0 COG1159@1|root,COG1159@2|Bacteria,4NES2@976|Bacteroidetes,2FN64@200643|Bacteroidia 976|Bacteroidetes S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1031299_1 1537917.JU82_01115 1.88e-137 394.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,42MPM@68525|delta/epsilon subdivisions,2YMX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_1031299_2 1244083.CSUNSWCD_1599 1.22e-15 72.4 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,42RJX@68525|delta/epsilon subdivisions,2YP8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_278558_1 1172188.KB911831_gene4028 1.28e-31 128.0 COG1404@1|root,COG4733@1|root,COG1404@2|Bacteria,COG4733@2|Bacteria,2GIRE@201174|Actinobacteria,4FGR4@85021|Intrasporangiaceae 201174|Actinobacteria O Subtilase family mycP - - ko:K14743 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_116916_1 1415775.U729_1986 5.59e-63 205.0 COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia,36FHV@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator - - - ko:K21900 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_116916_3 556263.FSEG_01981 2.72e-57 192.0 COG1207@1|root,COG1207@2|Bacteria,378XH@32066|Fusobacteria 32066|Fusobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3,NTP_transferase k59_705265_1 913325.N799_06955 2.7e-35 125.0 COG4706@1|root,COG4706@2|Bacteria,1RIH4@1224|Proteobacteria,1SFAZ@1236|Gammaproteobacteria,1X77B@135614|Xanthomonadales 135614|Xanthomonadales I dehydratase - - - - - - - - - - - - - k59_705265_2 1300345.LF41_3121 2.44e-13 70.1 COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1X5EV@135614|Xanthomonadales 135614|Xanthomonadales S membrane - - - - - - - - - - - - MMPL k59_542397_1 869213.JCM21142_52317 3.92e-36 131.0 COG1418@1|root,COG1418@2|Bacteria,4P7Y1@976|Bacteroidetes 976|Bacteroidetes S HD domain - - - - - - - - - - - - HD k59_1031309_1 237368.SCABRO_01551 2.24e-69 235.0 COG3696@1|root,COG3696@2|Bacteria,2IX94@203682|Planctomycetes 203682|Planctomycetes P AcrB/AcrD/AcrF family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_278561_1 876044.IMCC3088_2535 4.19e-116 357.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3IM@1236|Gammaproteobacteria,1J9GH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_679401_5 1071679.BG57_14490 1.54e-42 153.0 COG1082@1|root,COG1082@2|Bacteria,1RIA4@1224|Proteobacteria,2WFSB@28216|Betaproteobacteria,1K2PN@119060|Burkholderiaceae 28216|Betaproteobacteria G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_679401_6 1081644.IMCC13023_03510 3.08e-70 223.0 COG3510@1|root,COG3510@2|Bacteria 2|Bacteria V cephalosporin hydroxylase - - - - - - - - - - - - CmcI,Methyltransf_24 k59_613701_1 886293.Sinac_7397 6.49e-31 120.0 COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes 203682|Planctomycetes M PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_4 k59_805546_1 2340.JV46_18960 6.24e-21 96.3 COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,1JB3D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins gspL GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_548397_1 983545.Glaag_1551 8.84e-11 65.9 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,1S2FJ@1236|Gammaproteobacteria,46ASV@72275|Alteromonadaceae 1236|Gammaproteobacteria I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1005548_1 237368.SCABRO_00086 5.48e-98 295.0 COG2887@1|root,COG2887@2|Bacteria 2|Bacteria L Belongs to the helicase family. UvrD subfamily - - 3.6.4.12 ko:K10742 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - AAA_24,PDDEXK_1 k59_1005548_2 1122991.BAIZ01000003_gene387 1.43e-11 66.2 COG1285@1|root,COG1285@2|Bacteria,4NM47@976|Bacteroidetes,2FP38@200643|Bacteroidia 976|Bacteroidetes S Mg2 transporter-C family protein - - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC k59_55183_1 572544.Ilyop_0439 1.8e-60 205.0 COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,379S8@32066|Fusobacteria 32066|Fusobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_156668_1 363253.LI1147 7.19e-08 57.0 2DS6B@1|root,33ERK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_940149_1 518766.Rmar_2587 1.12e-09 57.8 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding crp - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - cNMP_binding k59_940149_2 457421.CBFG_03319 4.78e-15 76.6 COG0730@1|root,COG0730@2|Bacteria,1TRYJ@1239|Firmicutes,24GUD@186801|Clostridia 186801|Clostridia S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_841484_1 243233.MCA2566 6.21e-57 191.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,1RW77@1236|Gammaproteobacteria,1XGWE@135618|Methylococcales 135618|Methylococcales C FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_448967_1 1122194.AUHU01000002_gene2848 1.72e-14 81.3 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,4645X@72275|Alteromonadaceae 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_873845_1 879212.DespoDRAFT_01479 1.57e-67 218.0 COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,42VIF@68525|delta/epsilon subdivisions,2WRY1@28221|Deltaproteobacteria,2MQ11@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_384338_1 1408439.JHXW01000002_gene488 6.58e-29 107.0 COG0054@1|root,COG0054@2|Bacteria,379ZU@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_384344_1 1172190.M947_03680 4.51e-49 157.0 COG0776@1|root,COG0776@2|Bacteria,1QQYR@1224|Proteobacteria,42V36@68525|delta/epsilon subdivisions,2YQA9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the bacterial histone-like protein family hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_384344_2 563040.Saut_1696 1.92e-15 71.2 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42UDS@68525|delta/epsilon subdivisions 1224|Proteobacteria C Belongs to the MsrB Met sulfoxide reductase family msrB GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019538,GO:0030091,GO:0033743,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - iAF1260.b1778,iB21_1397.B21_01735,iBWG_1329.BWG_1591,iE2348C_1286.E2348C_1905,iEC042_1314.EC042_1944,iEC55989_1330.EC55989_1947,iECBD_1354.ECBD_1866,iECB_1328.ECB_01747,iECDH10B_1368.ECDH10B_1916,iECDH1ME8569_1439.ECDH1ME8569_1722,iECD_1391.ECD_01747,iECH74115_1262.ECH74115_2502,iECIAI39_1322.ECIAI39_1275,iECNA114_1301.ECNA114_1824,iECO103_1326.ECO103_1964,iECP_1309.ECP_1726,iECSE_1348.ECSE_1949,iECSF_1327.ECSF_1639,iECSP_1301.ECSP_2350,iECUMN_1333.ECUMN_2067,iECW_1372.ECW_m1947,iECs_1301.ECs2487,iEKO11_1354.EKO11_1997,iETEC_1333.ETEC_1810,iEcDH1_1363.EcDH1_1864,iEcE24377_1341.EcE24377A_2002,iEcSMS35_1347.EcSMS35_1413,iG2583_1286.G2583_2225,iJO1366.b1778,iLF82_1304.LF82_1402,iNRG857_1313.NRG857_08905,iPC815.YPO2158,iSSON_1240.SSON_1385,iWFL_1372.ECW_m1947,iY75_1357.Y75_RS09320,iYL1228.KPN_01198,iZ_1308.Z2817 SelR k59_776284_1 1249480.B649_10695 6.78e-93 302.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2YMP9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_646335_1 1122619.KB892279_gene1712 1.59e-86 278.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,3T1ET@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the oxidative decarboxylation of malate to form pyruvate maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_940167_1 493475.GARC_0699 2.44e-07 56.2 COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,1RMQK@1236|Gammaproteobacteria,469RD@72275|Alteromonadaceae 1236|Gammaproteobacteria G Strictosidine synthase - - - - - - - - - - - - Str_synth k59_940167_2 760192.Halhy_1694 1.4e-18 85.5 COG3621@1|root,COG3621@2|Bacteria,4NG71@976|Bacteroidetes,1IQQH@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_972352_1 1408473.JHXO01000010_gene3666 3.61e-28 113.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,2FWS8@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_972352_2 926556.Echvi_3084 1.41e-32 125.0 COG0702@1|root,COG0702@2|Bacteria,4NG5U@976|Bacteroidetes,47NVT@768503|Cytophagia 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_122924_1 452637.Oter_1363 7.56e-25 110.0 COG1501@1|root,COG1501@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Melibiase_2 k59_122924_2 357276.EL88_16540 9.95e-10 60.5 COG3507@1|root,COG3507@2|Bacteria,4NH4M@976|Bacteroidetes,2G2PT@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolases family 32 N-terminal domain - - - - - - - - - - - - Glyco_hydro_43 k59_448988_1 1501230.ET33_27720 8.9e-07 52.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBQY@91061|Bacilli,26SS5@186822|Paenibacillaceae 91061|Bacilli P With NikACDE is involved in nickel transport into the cell nikB - - ko:K15585 ko02010,map02010 M00440 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_448988_2 1487923.DP73_08895 1.26e-09 61.2 COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,263FT@186807|Peptococcaceae 186801|Clostridia E PFAM Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_122925_1 1282360.ABAC460_22860 1.48e-57 202.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2TV5M@28211|Alphaproteobacteria 28211|Alphaproteobacteria G alpha-L-rhamnosidase - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_106 k59_221420_1 1168034.FH5T_08540 1.16e-113 343.0 COG0366@1|root,COG0366@2|Bacteria,4NEXF@976|Bacteroidetes,2FMHS@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 13 family amyA2 GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016798,GO:0031216,GO:0044464,GO:0071944 3.2.1.135 ko:K21575 - - - - ko00000,ko01000 - GH13 - Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N k59_548459_1 1198232.CYCME_0884 1.29e-84 270.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4601N@72273|Thiotrichales 72273|Thiotrichales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_90169_1 1168034.FH5T_20505 4.18e-155 447.0 COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,2FMUA@200643|Bacteroidia 976|Bacteroidetes O peptidase Do htrA - - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_55225_1 42565.FP66_07630 4.71e-75 239.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1XHYI@135619|Oceanospirillales 135619|Oceanospirillales L Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates sbcB - 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_841517_1 1122915.AUGY01000016_gene2458 3.7e-32 122.0 COG3279@1|root,COG3279@2|Bacteria,1V14X@1239|Firmicutes,4HDIC@91061|Bacilli,26TBE@186822|Paenibacillaceae 91061|Bacilli T regulator - - - ko:K07705 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_711160_1 768671.ThimaDRAFT_0077 1.48e-60 201.0 COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria,1WXDD@135613|Chromatiales 135613|Chromatiales CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - Glutaredoxin k59_19425_1 1286632.P278_32550 2.47e-57 187.0 COG0457@1|root,COG0457@2|Bacteria,4NGID@976|Bacteroidetes,1HX60@117743|Flavobacteriia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - - k59_189142_1 1177928.TH2_03580 7.9e-73 237.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,2JPS3@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_90192_1 953739.SVEN_5076 1.64e-39 145.0 COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria 201174|Actinobacteria C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0409 Acetate_kinase k59_90192_2 525897.Dbac_1048 6.73e-08 52.8 COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,42MPY@68525|delta/epsilon subdivisions,2WJ2V@28221|Deltaproteobacteria,2M7Y6@213115|Desulfovibrionales 28221|Deltaproteobacteria C belongs to the CobB CobQ family pta - 2.3.1.8 ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1035 AAA_26,DRTGG,PTA_PTB k59_449032_1 1165841.SULAR_05343 2.04e-13 69.3 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2YT0S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q ABC-type transport system involved in resistance to organic solvents auxiliary component - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_449032_2 944546.ABED_1349 1.34e-16 80.9 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YM9E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL,Patched k59_516809_1 56780.SYN_01481 3.08e-36 142.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MQZ2@213462|Syntrophobacterales 28221|Deltaproteobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_90198_1 243274.THEMA_04870 1.05e-22 96.3 COG1514@1|root,COG1514@2|Bacteria,2GD19@200918|Thermotogae 200918|Thermotogae J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_1005609_1 1355368.JART01000019_gene985 2.21e-20 98.2 COG5001@1|root,COG5001@2|Bacteria,1R4H0@1224|Proteobacteria,42Q74@68525|delta/epsilon subdivisions,2YMQI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS_3,PAS_9 k59_548493_1 631362.Thi970DRAFT_04697 4.49e-75 251.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_449043_1 1297742.A176_06397 4.1e-26 106.0 COG1352@1|root,COG1352@2|Bacteria,1RDBE@1224|Proteobacteria,42RSH@68525|delta/epsilon subdivisions,2WNHY@28221|Deltaproteobacteria,2YXP4@29|Myxococcales 28221|Deltaproteobacteria NT Methyltransferase, chemotaxis proteins - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_516818_1 1168034.FH5T_12070 1.17e-90 275.0 COG3616@1|root,COG3616@2|Bacteria,4NF5K@976|Bacteroidetes,2FWV2@200643|Bacteroidia 976|Bacteroidetes E Putative serine dehydratase domain - - 4.3.1.27 ko:K20757 - - - - ko00000,ko01000 - - - Ala_racemase_N,D-ser_dehydrat k59_873910_2 1192124.LIG30_4831 2.24e-35 132.0 COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,2VKDX@28216|Betaproteobacteria,1K7GS@119060|Burkholderiaceae 28216|Betaproteobacteria Q depolymerase - - 3.1.1.75 ko:K05973 ko00650,map00650 - R05118 - ko00000,ko00001,ko01000 - - - Esterase_phd k59_253293_1 1469607.KK073765_gene6431 5.01e-48 159.0 COG3385@1|root,COG3385@2|Bacteria,1G2W3@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_907061_1 709986.Deima_1972 4.77e-41 151.0 COG2252@1|root,COG2252@2|Bacteria,1WM47@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Permease family - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k59_317696_1 497964.CfE428DRAFT_1142 1.32e-73 238.0 COG1502@1|root,COG1502@2|Bacteria,46U9X@74201|Verrucomicrobia 74201|Verrucomicrobia I Phospholipase D. Active site motifs. - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_873919_1 926550.CLDAP_26220 3.92e-63 204.0 COG1879@1|root,COG1879@2|Bacteria,2G6R2@200795|Chloroflexi 200795|Chloroflexi G Periplasmic binding proteins and sugar binding domain of LacI family - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_318166_1 522306.CAP2UW1_3924 4.61e-13 74.7 COG0515@1|root,COG1639@1|root,COG2203@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,COG2203@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria 28216|Betaproteobacteria T Metal-dependent hydrolase HDOD - - - - - - - - - - - - GAF_2,HDOD,Pkinase k59_157487_1 1121447.JONL01000002_gene1996 8.44e-50 172.0 COG4782@1|root,COG4782@2|Bacteria,1PSSD@1224|Proteobacteria,430S8@68525|delta/epsilon subdivisions,2WW3H@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Alpha/beta hydrolase of unknown function (DUF900) - - - - - - - - - - - - DUF900 k59_55822_1 1461694.ATO9_10665 1.53e-46 159.0 28KEA@1|root,2ZA0J@2|Bacteria,1R5TS@1224|Proteobacteria,2U48U@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Sulfotransferase domain - - 2.8.2.1 ko:K01014 ko05204,map05204 - R01242 RC00007,RC00128 ko00000,ko00001,ko01000 - - - Sulfotransfer_1 k59_874489_1 933262.AXAM01000001_gene339 1.23e-36 134.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MHUV@213118|Desulfobacterales 28221|Deltaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_874489_2 1121405.dsmv_2216 8.19e-29 105.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2WRDW@28221|Deltaproteobacteria,2MKUS@213118|Desulfobacterales 28221|Deltaproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_157489_1 697282.Mettu_0354 2.5e-81 263.0 COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Zn-dependent protease with chaperone function htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_123602_1 177437.HRM2_04000 5.85e-84 254.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MIE0@213118|Desulfobacterales 28221|Deltaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_680107_1 936548.HMPREF1136_2083 0.000449 46.6 COG1051@1|root,COG1051@2|Bacteria,2I2K3@201174|Actinobacteria,4D879@85005|Actinomycetales 201174|Actinobacteria F Belongs to the Nudix hydrolase family - - - - - - - - - - - - NUDIX k59_680107_2 765914.ThisiDRAFT_2424 3.04e-97 297.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales 135613|Chromatiales CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_549192_1 1123368.AUIS01000013_gene875 1.6e-73 222.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,2NCUZ@225057|Acidithiobacillales 225057|Acidithiobacillales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_549192_2 1249627.D779_3564 2.86e-19 79.7 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_842053_1 1168034.FH5T_05795 1.1e-174 522.0 COG3250@1|root,COG3250@2|Bacteria,4NKZX@976|Bacteroidetes,2FNTC@200643|Bacteroidia 976|Bacteroidetes G Beta galactosidase small chain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3 k59_189683_1 1280946.HY29_13005 5.7e-23 94.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria,43XQQ@69657|Hyphomonadaceae 28211|Alphaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_189683_2 1174504.AJTN02000022_gene4729 7.01e-18 79.7 COG4997@1|root,COG4997@2|Bacteria,1VEG6@1239|Firmicutes,4HKMC@91061|Bacilli,1ZHZ3@1386|Bacillus 91061|Bacilli S phosphoribosyl-ATP pyrophosphohydrolase - - - - - - - - - - - - PRA-PH k59_189683_3 1232410.KI421426_gene1405 4.72e-53 180.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,43S10@69541|Desulfuromonadales 28221|Deltaproteobacteria O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_711722_1 398720.MED217_09310 2.22e-87 267.0 COG3507@1|root,COG3507@2|Bacteria,4NJHA@976|Bacteroidetes,1I802@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_32N k59_385190_1 1168034.FH5T_00055 4.1e-117 361.0 COG0567@1|root,COG0567@2|Bacteria,4NEU9@976|Bacteroidetes,2FMXI@200643|Bacteroidia 976|Bacteroidetes C 2-oxoglutarate dehydrogenase C-terminal sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_972908_1 1168034.FH5T_19590 2.42e-74 234.0 COG1162@1|root,COG1162@2|Bacteria,4NE24@976|Bacteroidetes,2FM8Z@200643|Bacteroidia 976|Bacteroidetes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit - - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_842055_1 745411.B3C1_11364 9.04e-158 460.0 COG1785@1|root,COG4222@1|root,COG1785@2|Bacteria,COG4222@2|Bacteria,1PGTX@1224|Proteobacteria,1T9ZG@1236|Gammaproteobacteria,1JB1R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the alkaline phosphatase family - - - - - - - - - - - - - k59_549204_2 1168034.FH5T_10455 6.77e-82 253.0 COG4299@1|root,COG4299@2|Bacteria,4NH8T@976|Bacteroidetes 976|Bacteroidetes S COGs COG4299 conserved - - - - - - - - - - - - DUF5009 k59_940896_1 870187.Thini_2622 1.25e-89 269.0 COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,1RM8F@1236|Gammaproteobacteria,460H8@72273|Thiotrichales 72273|Thiotrichales S TIGRFAM urea ABC transporter, ATP-binding protein UrtD - - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C k59_940896_2 1397528.Q671_15895 2.86e-06 47.8 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,1XIQH@135619|Oceanospirillales 135619|Oceanospirillales E ABC transporter ATP-binding protein - - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_123631_1 96561.Dole_0224 2.89e-51 172.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42RU7@68525|delta/epsilon subdivisions,2WNTU@28221|Deltaproteobacteria,2MMKD@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_907532_2 572544.Ilyop_0995 4.5e-146 430.0 COG1376@1|root,COG1376@2|Bacteria,378W6@32066|Fusobacteria 32066|Fusobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - SH3_3,YkuD k59_517480_1 394503.Ccel_0859 2e-42 160.0 COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae 186801|Clostridia Q Beta-ketoacyl synthase - - - ko:K13612 - - - - ko00000,ko01004,ko01008 - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_680128_1 929558.SMGD1_0621 1.25e-118 369.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YNB5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_481879_1 202955.BBND01000002_gene618 0.000388 45.8 COG3184@1|root,COG3184@2|Bacteria,1NA5V@1224|Proteobacteria,1SF2P@1236|Gammaproteobacteria,3NNRJ@468|Moraxellaceae 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2059) - - - ko:K09924 - - - - ko00000 - - - DUF2059 k59_481879_2 1349767.GJA_1794 8.45e-43 143.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,474AU@75682|Oxalobacteraceae 28216|Betaproteobacteria O Thioredoxin trxC - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin k59_911496_1 931627.MycrhDRAFT_3897 6.85e-42 150.0 COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I419@201174|Actinobacteria,234R8@1762|Mycobacteriaceae 201174|Actinobacteria IK Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Trans_reg_C k59_715625_1 1172562.HCN_0284 5.27e-50 176.0 COG1479@1|root,COG1479@2|Bacteria,1NRBC@1224|Proteobacteria,42VMR@68525|delta/epsilon subdivisions,2YS8Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF1524) - - - - - - - - - - - - DUF1524,DUF262 k59_1009987_2 349520.PPE_02167 2.16e-51 170.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HBMF@91061|Bacilli,26R6I@186822|Paenibacillaceae 91061|Bacilli V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_845889_1 293826.Amet_3249 2.45e-35 138.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase nifL - - - - - - - - - - - EAL,GGDEF,PAS,PAS_9,SBP_bac_3 k59_321810_1 1457250.BBMO01000003_gene3060 1.86e-30 121.0 COG0294@1|root,arCOG02817@2157|Archaea,2XTGI@28890|Euryarchaeota,23S24@183963|Halobacteria 183963|Halobacteria H COG0285 Folylpolyglutamate synthase folCP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M,Pterin_bind k59_321810_2 96561.Dole_3044 1.98e-07 53.5 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_553640_1 861299.J421_1491 4.28e-77 248.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1ZSZ7@142182|Gemmatimonadetes 142182|Gemmatimonadetes CE Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3 k59_521448_1 1385514.N782_20075 1.35e-10 60.8 COG1670@1|root,COG1670@2|Bacteria,1V4R9@1239|Firmicutes 1239|Firmicutes J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3,Acetyltransf_4 k59_521448_2 383372.Rcas_3829 1.67e-33 130.0 COG0365@1|root,COG0365@2|Bacteria,2G7TW@200795|Chloroflexi,376EM@32061|Chloroflexia 32061|Chloroflexia I PFAM AMP-dependent synthetase and ligase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_390180_1 1317122.ATO12_01125 2.47e-127 377.0 COG2759@1|root,COG2759@2|Bacteria,4NG3E@976|Bacteroidetes,1HXR5@117743|Flavobacteriia,2YHPM@290174|Aquimarina 976|Bacteroidetes F Formate--tetrahydrofolate ligase fhs GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_94508_1 118797.XP_007457193.1 2.55e-28 110.0 COG0197@1|root,KOG3422@2759|Eukaryota,39S31@33154|Opisthokonta,3BPN3@33208|Metazoa,3DD65@33213|Bilateria 33208|Metazoa J Ribosomal protein S3, C-terminal domain - - - - - - - - - - - - KH_2,Ribosomal_S3_C k59_161961_1 935557.ATYB01000008_gene5406 1.21e-11 70.1 COG5295@1|root,COG5295@2|Bacteria,1QVUF@1224|Proteobacteria,2TXAM@28211|Alphaproteobacteria 28211|Alphaproteobacteria UW this gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - - - - - - - - - - - k59_684004_1 243233.MCA1687 6.58e-40 149.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales 135618|Methylococcales S AAA-like domain - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 k59_94510_1 1242864.D187_000898 2.43e-06 52.8 COG0699@1|root,COG0699@2|Bacteria,1RKUD@1224|Proteobacteria,432KX@68525|delta/epsilon subdivisions,2WYCG@28221|Deltaproteobacteria 28221|Deltaproteobacteria S 50S ribosome-binding GTPase - - - - - - - - - - - - MMR_HSR1 k59_553659_1 338966.Ppro_3681 7.76e-19 87.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria,43SY5@69541|Desulfuromonadales 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_357221_1 439235.Dalk_1445 1.49e-73 248.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MHZ6@213118|Desulfobacterales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_878474_1 572477.Alvin_1668 8e-108 328.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales 135613|Chromatiales CI TIGRFAM Oxaloacetate decarboxylase, alpha subunit - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_454930_2 1158610.UC3_02305 7.53e-58 196.0 COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4HCSN@91061|Bacilli,4B3MJ@81852|Enterococcaceae 91061|Bacilli G Periplasmic binding protein domain - - - ko:K17213 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 k59_454930_3 545243.BAEV01000050_gene3749 7.55e-57 187.0 COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,36F6A@31979|Clostridiaceae 186801|Clostridia K GntR domain protein - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR k59_127509_1 1328313.DS2_03915 2.14e-05 44.3 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,466X0@72275|Alteromonadaceae 1236|Gammaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_127509_2 765912.Thimo_2130 4.44e-124 359.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1WWK4@135613|Chromatiales 135613|Chromatiales J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_127509_3 519989.ECTPHS_00180 2.38e-61 194.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales 135613|Chromatiales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_127509_4 225849.swp_3768 1.57e-37 127.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,2QC5X@267890|Shewanellaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_521468_1 1111730.ATTM01000002_gene967 9.5e-66 214.0 COG0517@1|root,COG0517@2|Bacteria,4NHKP@976|Bacteroidetes,1HYR8@117743|Flavobacteriia,2NYJ5@237|Flavobacterium 976|Bacteroidetes S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1010661_2 1122599.AUGR01000006_gene3859 1.09e-18 88.2 2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,1SI4F@1236|Gammaproteobacteria,1XM09@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF3306) - - - - - - - - - - - - DUF3306 k59_878954_1 933262.AXAM01000086_gene2640 1.43e-83 256.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2WIWA@28221|Deltaproteobacteria,2MIT5@213118|Desulfobacterales 28221|Deltaproteobacteria HP PFAM ABC transporter related - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_1042873_1 1168034.FH5T_21800 9.2e-176 499.0 28HE2@1|root,2Z7QJ@2|Bacteria,4NFBA@976|Bacteroidetes,2FMTF@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF5103) - - - - - - - - - - - - DUF5103 k59_846529_1 1366050.N234_17240 1e-06 51.2 COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2VJB1@28216|Betaproteobacteria,1K0PI@119060|Burkholderiaceae 28216|Betaproteobacteria E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_945709_1 388413.ALPR1_12665 1.31e-78 253.0 COG3119@1|root,COG3119@2|Bacteria,4NEZJ@976|Bacteroidetes,47P3V@768503|Cytophagia 976|Bacteroidetes P Sulfatase - - - - - - - - - - - - Sulfatase k59_651148_1 314287.GB2207_05117 5.31e-43 158.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_322216_1 1121035.AUCH01000001_gene1942 4.57e-05 46.2 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KVIV@206389|Rhodocyclales 206389|Rhodocyclales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_322216_2 631362.Thi970DRAFT_04823 2.85e-52 179.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales 135613|Chromatiales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_486158_2 1479238.JQMZ01000001_gene2452 5.77e-12 67.8 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,43WZH@69657|Hyphomonadaceae 28211|Alphaproteobacteria S L,D-transpeptidase catalytic domain - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_781817_1 292415.Tbd_1229 7.72e-126 372.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,1KREB@119069|Hydrogenophilales 119069|Hydrogenophilales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_912034_1 563040.Saut_0785 1.32e-61 199.0 COG2204@1|root,COG2204@2|Bacteria,1QASN@1224|Proteobacteria,42RV2@68525|delta/epsilon subdivisions,2YP76@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Sigma54_activ_2,Sigma54_activat k59_194695_1 886293.Sinac_7544 1.63e-34 135.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,2J4YH@203682|Planctomycetes 203682|Planctomycetes T His Kinase A (phosphoacceptor - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_455572_1 1168034.FH5T_08020 6.77e-128 370.0 COG1082@1|root,COG1082@2|Bacteria,4NGBE@976|Bacteroidetes,2FNN2@200643|Bacteroidia 976|Bacteroidetes G AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N k59_455572_2 1168034.FH5T_08015 1.91e-107 319.0 COG0673@1|root,COG0673@2|Bacteria,4NFMS@976|Bacteroidetes,2FQ3R@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_810928_1 472759.Nhal_2241 8.15e-44 147.0 COG0355@1|root,COG0355@2|Bacteria,1N1NE@1224|Proteobacteria,1S9B5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C epsilon subunit - - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_810928_2 243233.MCA2698 2.71e-28 104.0 2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria,1SCI0@1236|Gammaproteobacteria,1XFNR@135618|Methylococcales 135618|Methylococcales S F0F1-ATPase subunit - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_194704_1 1168034.FH5T_16510 4.04e-172 501.0 COG0666@1|root,COG1835@1|root,COG0666@2|Bacteria,COG1835@2|Bacteria,4NPMU@976|Bacteroidetes 976|Bacteroidetes I Ankyrin repeats (many copies) - - - - - - - - - - - - Ank_2,Ank_4,Ank_5 k59_390771_1 526218.Sterm_3095 1.22e-92 280.0 COG0451@1|root,COG0451@2|Bacteria,379DD@32066|Fusobacteria 32066|Fusobacteria M Polysaccharide biosynthesis protein - - - - - - - - - - - - GDP_Man_Dehyd k59_61028_1 1122603.ATVI01000005_gene3502 4.26e-18 87.8 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 k59_61028_2 493475.GARC_2471 3.55e-38 133.0 COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Conserved Protein - - - - - - - - - - - - DUF1232 k59_651173_1 382464.ABSI01000005_gene1154 1.09e-53 186.0 COG0823@1|root,COG0823@2|Bacteria,46UYG@74201|Verrucomicrobia 74201|Verrucomicrobia U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_651173_2 1492738.FEM21_26910 1.59e-19 89.7 COG1725@1|root,COG1725@2|Bacteria,4PKHR@976|Bacteroidetes,1IJ9D@117743|Flavobacteriia,2P0SX@237|Flavobacterium 976|Bacteroidetes K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR,Peripla_BP_3 k59_421066_1 713586.KB900536_gene1799 2.93e-92 275.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1WWPI@135613|Chromatiales 135613|Chromatiales D TIGRFAM Cell division ATP-binding protein FtsE - - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_61029_1 1120959.ATXF01000006_gene1701 5.29e-62 199.0 2CA7I@1|root,30E5G@2|Bacteria,2IJ78@201174|Actinobacteria,4FREA@85023|Microbacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_554326_1 1168034.FH5T_16605 1.69e-46 156.0 COG1148@1|root,COG2878@1|root,COG1148@2|Bacteria,COG2878@2|Bacteria,4NFEB@976|Bacteroidetes,2FMPN@200643|Bacteroidia 976|Bacteroidetes C electron transport complex, RnfABCDGE type, B subunit rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_554326_2 449673.BACSTE_01271 1.94e-16 76.6 COG3086@1|root,COG3086@2|Bacteria,4NT5I@976|Bacteroidetes,2G2M3@200643|Bacteroidia,4AW0Q@815|Bacteroidaceae 976|Bacteroidetes T Positive regulator of sigma(E), RseC MucC - - - ko:K03803 - - - - ko00000,ko03021 - - - RseC_MucC k59_747320_1 1144319.PMI16_04989 1.91e-05 52.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VJQX@28216|Betaproteobacteria,478CY@75682|Oxalobacteraceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_651187_1 1172190.M947_02700 3.63e-57 192.0 2C99Z@1|root,2Z9YV@2|Bacteria,1N0B7@1224|Proteobacteria,42P3M@68525|delta/epsilon subdivisions,2YMWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3373) - - - - - - - - - - - - DUF3373 k59_684749_1 1123053.AUDG01000023_gene640 2.9e-84 272.0 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,1RN9S@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_421079_1 1168034.FH5T_07175 1.95e-199 573.0 COG0363@1|root,COG0363@2|Bacteria,4NDUN@976|Bacteroidetes,2FM2W@200643|Bacteroidia 976|Bacteroidetes G glucosamine-6-phosphate deaminase nagB - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso,PIG-L k59_846562_1 509190.Cseg_3749 5.5e-29 114.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,2KFR9@204458|Caulobacterales 204458|Caulobacterales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_977706_2 929558.SMGD1_1358 7.08e-85 260.0 28K48@1|root,2Z9T8@2|Bacteria,1R4TF@1224|Proteobacteria,42MAD@68525|delta/epsilon subdivisions,2YQ5M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF4405) - - - - - - - - - - - - DUF4405 k59_879012_1 765911.Thivi_0738 2.67e-27 114.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_879012_2 395494.Galf_0515 1.08e-08 52.8 COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2WAN7@28216|Betaproteobacteria,44W2Y@713636|Nitrosomonadales 28216|Betaproteobacteria S Zinc-finger domain - - - - - - - - - - - - zf-CHCC k59_61047_1 1123240.ATVO01000003_gene431 4.29e-62 211.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K18E@204457|Sphingomonadales 204457|Sphingomonadales CG Dehydrogenase - - 1.1.9.1 ko:K17760 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_684777_1 640081.Dsui_2007 5.25e-24 94.0 COG4327@1|root,COG4327@2|Bacteria,1NQBY@1224|Proteobacteria,2VV4C@28216|Betaproteobacteria,2KXAM@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4212) - - - - - - - - - - - - DUF4212 k59_421093_1 1165841.SULAR_10174 2.5e-116 352.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2YMEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1010737_1 485918.Cpin_4545 2.32e-127 387.0 COG3533@1|root,COG3533@2|Bacteria,4P23R@976|Bacteroidetes 976|Bacteroidetes S Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - - k59_194746_1 396588.Tgr7_1396 2.35e-88 275.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,1WW3E@135613|Chromatiales 135613|Chromatiales S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP k59_357730_2 1249480.B649_10635 8.06e-94 276.0 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,42TPI@68525|delta/epsilon subdivisions,2YP1Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_357730_3 709032.Sulku_2248 3.8e-25 99.0 COG1815@1|root,COG1815@2|Bacteria,1PSBA@1224|Proteobacteria,42VSQ@68525|delta/epsilon subdivisions,2YPMD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body - - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod k59_289684_1 1168034.FH5T_03520 7.74e-145 417.0 COG3206@1|root,COG3206@2|Bacteria,4NSFM@976|Bacteroidetes 976|Bacteroidetes M protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - - k59_289684_2 1168034.FH5T_03525 2.41e-36 136.0 COG3307@1|root,COG3307@2|Bacteria,4NMYT@976|Bacteroidetes 976|Bacteroidetes M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_912089_1 1158146.KB907122_gene481 1.03e-40 140.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1WYI3@135613|Chromatiales 135613|Chromatiales S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_912089_2 935863.AWZR01000005_gene2284 1.16e-47 168.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1X3CI@135614|Xanthomonadales 135614|Xanthomonadales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_258509_1 563040.Saut_0775 2.68e-79 244.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2YMRV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_61060_1 338966.Ppro_1271 6.27e-91 269.0 COG1715@1|root,COG1715@2|Bacteria,1RABH@1224|Proteobacteria,42X1S@68525|delta/epsilon subdivisions,2WXD2@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Restriction endonuclease - - - - - - - - - - - - - k59_61060_2 870187.Thini_3489 7.69e-101 303.0 COG2865@1|root,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,1RQTX@1236|Gammaproteobacteria,460X9@72273|Thiotrichales 72273|Thiotrichales K PFAM ATPase associated with various cellular activities, AAA-4 - - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AlbA_2,HATPase_c_4,HTH_24 k59_619245_2 827.JFJK01000015_gene416 6.57e-21 92.0 COG2165@1|root,COG2165@2|Bacteria,1RF6W@1224|Proteobacteria,42VF3@68525|delta/epsilon subdivisions,2YQ6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_1010754_1 1117318.PRUB_11186 1.73e-05 47.4 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,2PZVN@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_1010754_2 1300345.LF41_1213 3.07e-52 175.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,1X35P@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_455637_1 56780.SYN_02576 8.27e-69 231.0 COG0784@1|root,COG3437@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MR92@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg k59_258521_1 105559.Nwat_0645 1.15e-92 277.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales 135613|Chromatiales O TIGRFAM FeS assembly ATPase SufC - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_128148_1 572544.Ilyop_1747 7.03e-191 541.0 COG0554@1|root,COG0554@2|Bacteria,3799Z@32066|Fusobacteria 32066|Fusobacteria H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_322300_1 563040.Saut_0003 2.82e-203 584.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2YMUW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_196946_1 335543.Sfum_2964 2.17e-43 152.0 2F2II@1|root,33VFH@2|Bacteria,1N6CV@1224|Proteobacteria,42UDX@68525|delta/epsilon subdivisions,2WR4C@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_458522_1 563040.Saut_1668 2.48e-22 101.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2YMUQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_654709_1 572544.Ilyop_1108 3.96e-69 213.0 COG0127@1|root,COG0127@2|Bacteria,3789A@32066|Fusobacteria 32066|Fusobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_654709_2 469606.FSCG_01727 3.95e-14 72.0 COG0127@1|root,COG0689@1|root,COG0127@2|Bacteria,COG0689@2|Bacteria,3794V@32066|Fusobacteria 32066|Fusobacteria J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - Ham1p_like,RNase_PH,RNase_PH_C k59_818024_2 1117318.PRUB_18450 6.02e-45 157.0 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1RPXT@1236|Gammaproteobacteria,2Q3D8@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S ErfK YbiS YcfS YnhG family protein yafK - - - - - - - - - - - YkuD k59_262304_1 644282.Deba_1795 2.26e-23 90.1 COG1652@1|root,COG1652@2|Bacteria,1MYYF@1224|Proteobacteria,42SCF@68525|delta/epsilon subdivisions,2WPR6@28221|Deltaproteobacteria 28221|Deltaproteobacteria S LysM domain - - - - - - - - - - - - - k59_262304_2 1232437.KL661986_gene3647 2.25e-158 461.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2WIJ0@28221|Deltaproteobacteria,2MITQ@213118|Desulfobacterales 28221|Deltaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_425737_1 1384065.JAGS01000001_gene3151 9.44e-43 150.0 COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,3WGTY@541000|Ruminococcaceae 186801|Clostridia F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate punA - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_98931_1 572480.Arnit_0712 1.39e-67 224.0 arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,42P6Y@68525|delta/epsilon subdivisions,2YMZI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_621953_1 1033810.HLPCO_000211 5.01e-85 267.0 COG0392@1|root,COG0392@2|Bacteria 2|Bacteria M lysyltransferase activity mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_785331_1 1121403.AUCV01000002_gene547 7.08e-20 90.9 COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria,2MI8M@213118|Desulfobacterales 28221|Deltaproteobacteria P TIGRFAM potassium uptake protein, TrkH family ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_785331_2 644282.Deba_0314 1.68e-77 248.0 COG2770@1|root,COG4191@1|root,COG2770@2|Bacteria,COG4191@2|Bacteria,1P0U1@1224|Proteobacteria,42PTP@68525|delta/epsilon subdivisions,2WJ8U@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_850789_1 387093.SUN_0212 1.51e-76 236.0 COG0602@1|root,COG0602@2|Bacteria,1PDNI@1224|Proteobacteria,42R24@68525|delta/epsilon subdivisions,2YN2N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14 k59_295042_1 635013.TherJR_1008 1.04e-20 94.7 COG0419@1|root,COG0419@2|Bacteria,1V5Y4@1239|Firmicutes,24HW6@186801|Clostridia 186801|Clostridia L SMC domain protein - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23 k59_295042_2 536227.CcarbDRAFT_0232 6.71e-208 587.0 COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,36EUA@31979|Clostridiaceae 186801|Clostridia E Belongs to the aspartokinase family thrA - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_295042_3 1128398.Curi_c00700 2.38e-132 384.0 COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia,26AH0@186813|unclassified Clostridiales 186801|Clostridia E GHMP kinases N terminal domain thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS03525 GHMP_kinases_C,GHMP_kinases_N k59_164361_2 469618.FVAG_02203 2.64e-39 153.0 COG1538@1|root,COG1538@2|Bacteria,378ZY@32066|Fusobacteria 32066|Fusobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_164361_3 864069.MicloDRAFT_00039640 7.44e-05 53.1 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,1JZ5A@119045|Methylobacteriaceae 28211|Alphaproteobacteria M Biotin-lipoyl like - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_164361_4 469618.FVAG_02201 4.72e-101 299.0 COG1136@1|root,COG1136@2|Bacteria,3783V@32066|Fusobacteria 32066|Fusobacteria V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_164361_5 316274.Haur_1604 6.21e-09 60.8 COG0577@1|root,COG0577@2|Bacteria,2G65B@200795|Chloroflexi,37660@32061|Chloroflexia 32061|Chloroflexia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_654726_1 1165841.SULAR_10364 9.09e-95 308.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2YMP9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_850791_1 545276.KB898725_gene823 4.2e-90 278.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_33578_1 700598.Niako_0739 7.22e-48 172.0 COG0446@1|root,COG0446@2|Bacteria,4PNU3@976|Bacteroidetes,1IUSQ@117747|Sphingobacteriia 976|Bacteroidetes S SPTR RagB SusD domain protein - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_131562_1 572544.Ilyop_0819 4e-100 310.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process galA - - - - - - - - - - - Beta_helix,CBM_4_9,CBM_6,DUF1565 k59_818042_1 307480.IW16_20310 2.95e-09 55.8 COG0454@1|root,COG0454@2|Bacteria,4PM4X@976|Bacteroidetes,1IJJI@117743|Flavobacteriia,3ZUPF@59732|Chryseobacterium 976|Bacteroidetes K FR47-like protein - - - ko:K03830 - - - - ko00000,ko01000 - - - Acetyltransf_10 k59_818042_2 1123242.JH636435_gene2484 1.99e-08 57.4 COG1520@1|root,COG1520@2|Bacteria,2IXQF@203682|Planctomycetes 203682|Planctomycetes S PQQ-like domain - - - - - - - - - - - - PQQ_2 k59_393201_1 1492738.FEM21_13330 1.27e-69 217.0 COG1028@1|root,COG1028@2|Bacteria,4NG8R@976|Bacteroidetes,1HX7K@117743|Flavobacteriia,2NUJ1@237|Flavobacterium 976|Bacteroidetes IQ PRINTS Short-chain dehydrogenase reductase (SDR) superfamily signature uxuB_1 - - - - - - - - - - - adh_short_C2 k59_295047_1 1167006.UWK_00134 1.78e-54 184.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MJ57@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_850797_1 1168034.FH5T_11545 2.22e-108 319.0 COG1077@1|root,COG1077@2|Bacteria,4NETQ@976|Bacteroidetes,2FM2I@200643|Bacteroidia 976|Bacteroidetes D Cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_66125_2 768671.ThimaDRAFT_0771 5.38e-43 145.0 COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1WYG0@135613|Chromatiales 135613|Chromatiales N Host attachment protein - - - - - - - - - - - - Host_attach k59_66125_3 1168067.JAGP01000001_gene875 4.23e-48 159.0 2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,1S9MI@1236|Gammaproteobacteria,460X6@72273|Thiotrichales 72273|Thiotrichales S Domain of unknown function (DUF1841) - - - - - - - - - - - - DUF1841 k59_66125_5 1056512.D515_02298 6.39e-16 90.1 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T5JU@1236|Gammaproteobacteria,1Y3C5@135623|Vibrionales 135623|Vibrionales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg k59_66125_6 768671.ThimaDRAFT_0931 1.09e-102 304.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,1WWBK@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_66125_7 754476.Q7A_2661 9.34e-72 224.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,460RQ@72273|Thiotrichales 72273|Thiotrichales C Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_66125_8 1049564.TevJSym_bq00050 1.23e-143 416.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1J55P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944 - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_66125_9 768671.ThimaDRAFT_0934 1.75e-160 474.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWSK@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_66125_10 399741.Spro_2240 4.72e-62 197.0 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,3ZZVT@613|Serratia 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfB GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114 - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_66125_11 105559.Nwat_2067 4.29e-101 296.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1WX8K@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_66125_12 1049564.TevJSym_af01070 0.0 1117.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1J4VI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Anticodon_1,tRNA-synt_1g,tRNA_bind k59_66125_13 2340.JV46_06490 4.51e-210 587.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1J4F3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_66125_15 1273103.NM10_05683 2.49e-06 54.7 COG1309@1|root,COG1309@2|Bacteria,1V76F@1239|Firmicutes,4H4WQ@909932|Negativicutes 909932|Negativicutes K Domain of unknown function (DUF1956) - - - - - - - - - - - - DUF1956,TetR_N k59_66125_17 279714.FuraDRAFT_3478 0.0 1210.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,2KQCR@206351|Neisseriales 206351|Neisseriales C Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_66125_18 768671.ThimaDRAFT_3925 9.52e-88 262.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,1RPQV@1236|Gammaproteobacteria,1WVZT@135613|Chromatiales 135613|Chromatiales O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_229745_1 714943.Mucpa_6874 2.82e-57 192.0 COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1INN3@117747|Sphingobacteriia 976|Bacteroidetes E PFAM Aminotransferase class I and II - - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_262325_1 420324.KI912007_gene8768 6.65e-106 318.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria,1JRWP@119045|Methylobacteriaceae 28211|Alphaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_850802_2 1293054.HSACCH_00649 3.24e-65 219.0 COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,3WA9X@53433|Halanaerobiales 186801|Clostridia C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_33591_1 1168034.FH5T_00415 2.13e-63 211.0 COG1934@1|root,COG1934@2|Bacteria,4PKT4@976|Bacteroidetes,2G3HG@200643|Bacteroidia 976|Bacteroidetes S OstA-like protein - - - - - - - - - - - - OstA_2 k59_883514_1 401526.TcarDRAFT_2496 3.16e-06 52.4 COG0845@1|root,COG0845@2|Bacteria,1V036@1239|Firmicutes,4H211@909932|Negativicutes 909932|Negativicutes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_556630_2 669502.SSDC_00985 1.58e-39 147.0 COG0236@1|root,COG0300@1|root,COG1020@1|root,COG1022@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG0300@2|Bacteria,COG1020@2|Bacteria,COG1022@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria 28216|Betaproteobacteria Q Amino acid adenylation domain - - - ko:K13611,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_458562_1 698769.JFBD01000017_gene2129 1.3e-34 122.0 COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,4HIKH@91061|Bacilli,4C5SE@84406|Virgibacillus 91061|Bacilli J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_458562_2 225117.XP_009350076.1 1.07e-192 570.0 COG0050@1|root,COG0480@1|root,KOG0460@2759|Eukaryota,KOG0465@2759|Eukaryota,37K55@33090|Viridiplantae,3G82M@35493|Streptophyta,4JJGU@91835|fabids 35493|Streptophyta J Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_458562_3 1007104.SUS17_2599 0.000271 45.8 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TU6Z@28211|Alphaproteobacteria,2KD4X@204457|Sphingomonadales 204457|Sphingomonadales E Peptidase family M3 - - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_850808_1 1165841.SULAR_01628 7.46e-46 149.0 COG2010@1|root,COG2010@2|Bacteria,1QA9H@1224|Proteobacteria,42VAH@68525|delta/epsilon subdivisions,2YQGU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_850808_2 1172190.M947_02690 2.51e-13 66.6 28QM5@1|root,3192M@2|Bacteria,1Q1JK@1224|Proteobacteria,42TV6@68525|delta/epsilon subdivisions,2YPT2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_916190_1 1500890.JQNL01000001_gene2392 1.27e-28 110.0 COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,1S43Y@1236|Gammaproteobacteria,1X5SW@135614|Xanthomonadales 135614|Xanthomonadales S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_916190_2 1379270.AUXF01000007_gene1035 1.55e-47 162.0 2DM5T@1|root,31U0Y@2|Bacteria,1ZUND@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_916190_3 1207063.P24_02111 3.4e-73 232.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,2JPY6@204441|Rhodospirillales 204441|Rhodospirillales L COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding - - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_949362_2 177437.HRM2_26770 3.1e-06 48.1 COG0250@1|root,COG0250@2|Bacteria,1QTE5@1224|Proteobacteria,42QT0@68525|delta/epsilon subdivisions,2WN4B@28221|Deltaproteobacteria,2MJNB@213118|Desulfobacterales 28221|Deltaproteobacteria K Transcription termination factor nusG - - - ko:K05785 - - - - ko00000,ko03000 - - - NusG k59_426249_1 1121396.KB892901_gene2209 5.94e-06 47.4 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,42NNE@68525|delta/epsilon subdivisions,2WJZX@28221|Deltaproteobacteria,2MI6X@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit qmoB - - ko:K16886 - - - - ko00000 - - - Fer4,Fer4_9,FlpD,Pyr_redox_2 k59_426249_2 485915.Dret_1963 6.22e-52 176.0 COG1150@1|root,COG2181@1|root,COG1150@2|Bacteria,COG2181@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2M85U@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain qmoC - - ko:K16887 - - - - ko00000 - - - Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam k59_99422_1 1168034.FH5T_08900 1e-165 468.0 COG0224@1|root,COG0224@2|Bacteria,4NECM@976|Bacteroidetes,2FP5N@200643|Bacteroidia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_687861_1 395495.Lcho_3065 4.33e-143 417.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,1KIZQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_164957_1 1499967.BAYZ01000084_gene3996 2.06e-33 124.0 COG1214@1|root,COG1214@2|Bacteria,2NPK8@2323|unclassified Bacteria 2|Bacteria O Glycoprotease family yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_262652_1 28229.ND2E_0290 5.01e-62 216.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,2Q5QE@267889|Colwelliaceae 1236|Gammaproteobacteria E PFAM ferredoxin-dependent glutamate synthase, glutamine amidotransferase class-II, glutamate synthase, glutamate synthase alpha subunit domain protein gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_459095_1 1201293.AKXQ01000007_gene514 2.09e-59 191.0 COG2433@1|root,COG2433@2|Bacteria,1QYSX@1224|Proteobacteria,1RX8U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_197499_1 709032.Sulku_0996 1.04e-54 176.0 COG0666@1|root,COG0666@2|Bacteria,1Q2UY@1224|Proteobacteria,42WAJ@68525|delta/epsilon subdivisions,2YQKP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ankyrin repeat - - - - - - - - - - - - Ank_2,Ank_4,Ank_5 k59_197499_2 911008.GLAD_02688 0.000355 42.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Secondary thiamine-phosphate synthase enzyme yjbQ - - - - - - - - - - - UPF0047 k59_491678_1 1165841.SULAR_06418 1.63e-102 310.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2YMQ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_491678_2 1165841.SULAR_06423 3.78e-36 130.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2YMK7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_622480_1 1537917.JU82_06065 4.87e-20 82.4 COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,42V0C@68525|delta/epsilon subdivisions,2YQBD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Redox-active disulfide protein - - - - - - - - - - - - Thioredoxin_3 k59_622480_2 1122173.AXVL01000022_gene2141 2.72e-69 223.0 COG1533@1|root,COG1533@2|Bacteria,37C07@32066|Fusobacteria 32066|Fusobacteria L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_622480_3 469618.FVAG_02223 8.42e-132 395.0 COG3275@1|root,COG3275@2|Bacteria,37865@32066|Fusobacteria 32066|Fusobacteria T 5TMR of 5TMR-LYT - - 2.7.13.3 ko:K02478 - - - - ko00000,ko01000,ko01001,ko02022 - - - 5TM-5TMR_LYT,HATPase_c,His_kinase k59_393711_1 472759.Nhal_3926 1.26e-52 185.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales 135613|Chromatiales U Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_427611_2 1094980.Mpsy_1397 4.61e-59 191.0 COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,2N99Z@224756|Methanomicrobia 224756|Methanomicrobia F aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - iAF692.Mbar_A1168 OTCace,OTCace_N k59_722091_1 572477.Alvin_2188 7.23e-83 259.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales 135613|Chromatiales S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_231825_1 1165841.SULAR_07380 5.3e-123 377.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,42PUG@68525|delta/epsilon subdivisions,2YN09@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB-dependent copper receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_362417_2 1168034.FH5T_20975 5.96e-85 251.0 COG0432@1|root,COG0432@2|Bacteria,4NNMN@976|Bacteroidetes,2FSG1@200643|Bacteroidia 976|Bacteroidetes S Secondary thiamine-phosphate synthase enzyme yjbQ - - - - - - - - - - - UPF0047 k59_951050_1 243090.RB154 0.000107 50.8 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - - - - - - - - - - - ASH,Cadherin,DUF11,DUF4347,DUF5122,He_PIG,Laminin_G_3,SBBP k59_983387_1 1303518.CCALI_01384 6.99e-30 115.0 COG1660@1|root,COG1660@2|Bacteria 2|Bacteria S GTP binding rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_623964_2 1123511.KB905847_gene3061 9.29e-185 521.0 COG0464@1|root,COG0464@2|Bacteria,1TSG1@1239|Firmicutes,4H33T@909932|Negativicutes 909932|Negativicutes O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_623964_3 1123511.KB905847_gene3062 0.0 1014.0 COG1404@1|root,COG1404@2|Bacteria,1TRSQ@1239|Firmicutes,4H3G9@909932|Negativicutes 909932|Negativicutes O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_918546_2 1121396.KB893128_gene4399 3.12e-23 97.8 COG2890@1|root,COG2890@2|Bacteria,1R0BP@1224|Proteobacteria,43CU1@68525|delta/epsilon subdivisions,2WUPH@28221|Deltaproteobacteria 28221|Deltaproteobacteria J O-methyltransferase - - - - - - - - - - - - Methyltransf_2 k59_853013_1 1136534.J9PUM4_9CAUD 8.24e-55 189.0 4QY3P@35237|dsDNA viruses no RNA stage,4QQ7H@28883|Caudovirales,4QK0H@10662|Myoviridae 10662|Myoviridae S Terminase-like family - - - - - - - - - - - - - k59_297019_1 751944.HALDL1_04210 2.36e-08 56.6 COG0210@1|root,arCOG00802@2157|Archaea,2XTJI@28890|Euryarchaeota,240XV@183963|Halobacteria 183963|Halobacteria L COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_297019_2 639283.Snov_3407 8.42e-38 133.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2TTN7@28211|Alphaproteobacteria,3EZ97@335928|Xanthobacteraceae 28211|Alphaproteobacteria F Phosphoribosyl transferase domain hpt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_362429_1 1089447.RHAA1_01009 4.75e-52 184.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1Y7XT@135625|Pasteurellales 135625|Pasteurellales EGIPQ Phosphate acyltransferases - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_657113_1 395494.Galf_1639 7.54e-55 194.0 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,44W6A@713636|Nitrosomonadales 28216|Betaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - DUF4118,EAL,GGDEF,PAS,PAS_9,Phosphonate-bd k59_657113_2 998088.B565_1807 1.05e-09 57.4 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1Y4P1@135624|Aeromonadales 135624|Aeromonadales H riboflavin synthase, alpha - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_101093_1 765913.ThidrDRAFT_3404 5.4e-102 312.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales 135613|Chromatiales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_68150_1 1158146.KB907134_gene1478 3.85e-45 154.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria,1WW5S@135613|Chromatiales 135613|Chromatiales C nitrate reductase activity - - - - - - - - - - - - - k59_166660_1 1121385.AQXW01000004_gene2650 6.34e-26 108.0 COG3340@1|root,COG3340@2|Bacteria,2IGG2@201174|Actinobacteria 201174|Actinobacteria E Belongs to the peptidase S51 family - - - - - - - - - - - - Peptidase_S51 k59_264162_1 1095769.CAHF01000003_gene1060 7.82e-22 95.5 COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,2VJ7R@28216|Betaproteobacteria,476ZK@75682|Oxalobacteraceae 28216|Betaproteobacteria V ABC-2 type transporter nodJ - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane k59_198974_2 1541960.KQ78_00216 6.7e-18 95.1 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - AAA_23,Apolipoprotein k59_591273_1 1415780.JPOG01000001_gene1933 1.42e-61 212.0 COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1X3FC@135614|Xanthomonadales 135614|Xanthomonadales CJ GCN5 family acetyltransferase - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_231837_1 572544.Ilyop_1757 9.98e-15 73.2 COG0162@1|root,COG0162@2|Bacteria,378M9@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_231837_3 1172190.M947_06675 4.87e-18 85.5 COG3713@1|root,COG3713@2|Bacteria,1MXXC@1224|Proteobacteria,42XV8@68525|delta/epsilon subdivisions,2YRZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M MltA-interacting MipA family protein - - - ko:K07274 - - - - ko00000,ko02000 9.B.99.1 - - - k59_657133_1 572477.Alvin_1853 6.49e-38 140.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1WX31@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_689490_1 459495.SPLC1_S371140 5.3e-158 464.0 COG0457@1|root,COG4225@1|root,COG0457@2|Bacteria,COG4225@2|Bacteria,1GIAH@1117|Cyanobacteria,1HFNG@1150|Oscillatoriales 1117|Cyanobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_8 k59_526149_1 197221.22294227 1.49e-29 117.0 COG0008@1|root,COG0008@2|Bacteria,1G1X2@1117|Cyanobacteria 1117|Cyanobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_526149_2 1122997.AUDD01000009_gene299 2.85e-09 62.8 COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4DN0T@85009|Propionibacteriales 201174|Actinobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227,6.3.2.8 ko:K01924,ko:K02563 ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112 - R03193,R05032,R05662 RC00005,RC00049,RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_951085_1 1385517.N800_04685 3.93e-92 297.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X34J@135614|Xanthomonadales 135614|Xanthomonadales V Efflux pump membrane transporter mexB - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_297038_1 1249480.B649_11045 8.02e-98 296.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2YMD8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_297038_2 709032.Sulku_2329 5.4e-115 335.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2YMWJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C pyruvate ferredoxin oxidoreductase porB - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_133971_1 765913.ThidrDRAFT_0747 6.37e-57 182.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1WWYC@135613|Chromatiales 135613|Chromatiales JM PFAM Nucleotidyl transferase - - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_657140_1 572544.Ilyop_0795 8.3e-120 350.0 COG0820@1|root,COG0820@2|Bacteria,37847@32066|Fusobacteria 32066|Fusobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_101116_1 1122176.KB903543_gene521 1.88e-09 66.6 COG3291@1|root,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1IS57@117747|Sphingobacteriia 976|Bacteroidetes S C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,PKD k59_558938_1 102125.Xen7305DRAFT_00042480 9.05e-84 251.0 COG0700@1|root,COG0700@2|Bacteria,1G3TV@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Nucleoside recognition - - - ko:K06374 - - - - ko00000 - - - Gate k59_198997_1 1121448.DGI_2643 6.23e-87 268.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_624007_1 477228.YO5_05204 1.59e-31 123.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1YZPG@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria I Long-chain acyl-CoA - - - - - - - - - - - - AMP-binding,Haem_oxygenas_2 k59_363002_2 713587.THITH_08770 1.43e-109 327.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales 135613|Chromatiales C TIGRFAM isocitrate dehydrogenase, NADP-dependent - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - CBS,Iso_dh k59_559585_1 1049564.TevJSym_au00170 2.15e-65 200.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,1J6AQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C ferredoxin, 2Fe-2S fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_559585_2 1049564.TevJSym_au00180 3.26e-34 117.0 COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria,1J6W7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria iscX GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - - - - - - - - - - Fe-S_assembly k59_2428_2 697282.Mettu_0389 1.52e-62 201.0 COG2236@1|root,COG2236@2|Bacteria,1RKB0@1224|Proteobacteria,1S7J1@1236|Gammaproteobacteria,1XFMX@135618|Methylococcales 135618|Methylococcales F Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran k59_494000_1 1296415.JACC01000015_gene826 2.6e-77 246.0 COG4147@1|root,COG4147@2|Bacteria,4NHPT@976|Bacteroidetes,1HXQN@117743|Flavobacteriia,2YHN0@290174|Aquimarina 976|Bacteroidetes S Sodium:solute symporter family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_494000_2 1131269.AQVV01000016_gene1854 4.4e-34 120.0 COG4327@1|root,COG4327@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4212) - - - - - - - - - - - - DUF4212 k59_101783_1 661478.OP10G_0838 9.5e-35 133.0 COG0665@1|root,COG0665@2|Bacteria 2|Bacteria E tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_101783_2 1239962.C943_03761 7.92e-19 84.7 COG0276@1|root,COG0276@2|Bacteria,4NE83@976|Bacteroidetes,47JH0@768503|Cytophagia 976|Bacteroidetes H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_330691_1 1121859.KB890758_gene1821 4.66e-49 167.0 COG2357@1|root,COG2357@2|Bacteria,4NY1Y@976|Bacteroidetes 976|Bacteroidetes S Region found in RelA / SpoT proteins - - - - - - - - - - - - RelA_SpoT k59_657784_1 196164.23492944 4.49e-09 62.4 COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,22MCA@1653|Corynebacteriaceae 201174|Actinobacteria G COG0406 Fructose-2,6-bisphosphatase - - - - - - - - - - - - His_Phos_1 k59_657784_2 720554.Clocl_0224 8.03e-66 210.0 COG1713@1|root,COG1713@2|Bacteria,1UJ6P@1239|Firmicutes,25EWR@186801|Clostridia,3WSMH@541000|Ruminococcaceae 186801|Clostridia H HD domain - - - - - - - - - - - - HD k59_35812_1 1111121.HMPREF1247_0186 3.28e-18 84.0 COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,4CU96@84998|Coriobacteriia 84998|Coriobacteriia F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_35812_2 33035.JPJF01000080_gene145 2.11e-16 77.8 COG2703@1|root,COG2703@2|Bacteria,1VAI0@1239|Firmicutes,24MQU@186801|Clostridia,3XZZH@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_35812_3 1247726.MIM_c14530 1.06e-57 182.0 COG0662@1|root,COG0662@2|Bacteria,1RJ7D@1224|Proteobacteria,2VU1R@28216|Betaproteobacteria,3T3YE@506|Alcaligenaceae 28216|Betaproteobacteria G AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 k59_35812_4 317025.Tcr_2200 1.22e-21 89.0 COG0350@1|root,COG0350@2|Bacteria 2|Bacteria L methylated-DNA-[protein]-cysteine S-methyltransferase activity ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_134558_2 196367.JNFG01000036_gene7760 5.44e-14 71.2 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1K3TE@119060|Burkholderiaceae 28216|Betaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_1016783_1 84531.JMTZ01000012_gene2933 1.62e-26 112.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RMM6@1236|Gammaproteobacteria,1X2Y6@135614|Xanthomonadales 135614|Xanthomonadales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_787956_1 857087.Metme_3969 2.83e-31 119.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1XDJP@135618|Methylococcales 135618|Methylococcales S PFAM Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_461550_1 1358423.N180_08685 2.97e-40 145.0 COG1064@1|root,COG1064@2|Bacteria,4NFGP@976|Bacteroidetes,1IPFK@117747|Sphingobacteriia 976|Bacteroidetes C alcohol dehydrogenase - - - ko:K13979 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_461550_2 1122226.AUHX01000006_gene2143 6.82e-16 73.6 COG1917@1|root,COG1917@2|Bacteria,4NRJA@976|Bacteroidetes,1I39M@117743|Flavobacteriia 976|Bacteroidetes S Cupin domain - - - - - - - - - - - - Cupin_2 k59_232395_1 765911.Thivi_1153 3.17e-39 141.0 28JN1@1|root,2Z9EG@2|Bacteria,1R8TZ@1224|Proteobacteria,1S1S0@1236|Gammaproteobacteria,1WXT2@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_690067_1 472759.Nhal_2019 7.82e-64 215.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales 135613|Chromatiales L Helicase - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2 k59_624603_1 572544.Ilyop_1901 1.18e-193 572.0 COG1197@1|root,COG1197@2|Bacteria,378H0@32066|Fusobacteria 32066|Fusobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_885714_1 557599.MKAN_01665 8.82e-39 141.0 COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria,2338B@1762|Mycobacteriaceae 201174|Actinobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_885714_2 204773.HEAR2507 5.52e-49 163.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VUIT@28216|Betaproteobacteria,476WJ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_559609_2 768671.ThimaDRAFT_4618 8.11e-105 315.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales 135613|Chromatiales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_101805_1 237609.PSAKL28_25670 3.89e-45 169.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_853525_1 1121334.KB911066_gene775 8.68e-100 298.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,3WG9Z@541000|Ruminococcaceae 186801|Clostridia E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_134578_1 1408428.JNJP01000005_gene78 5.58e-19 82.4 COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,2MH6C@213115|Desulfovibrionales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase korC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_134578_2 1121405.dsmv_1295 2.57e-61 196.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,2MIEW@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Thiamine pyrophosphate - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_461563_1 1168034.FH5T_06070 2.47e-149 434.0 COG0402@1|root,COG0402@2|Bacteria,4NJVU@976|Bacteroidetes 976|Bacteroidetes F amidohydrolase - - 3.5.4.40 ko:K20810 ko00130,ko01110,map00130,map01110 - R10695 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_461563_2 1287476.HMPREF1651_00950 3.85e-05 44.7 COG0042@1|root,COG0042@2|Bacteria,4NEN4@976|Bacteroidetes,2FM9Z@200643|Bacteroidia 976|Bacteroidetes H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - - - - - - - - - - Dus k59_264705_1 1433126.BN938_2022 1.03e-63 207.0 COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,2FQ2M@200643|Bacteroidia 976|Bacteroidetes S Peptidase, M28 family - - - - - - - - - - - - Peptidase_M28 k59_919263_1 1168034.FH5T_00365 1.9e-119 345.0 COG0175@1|root,COG0175@2|Bacteria,4NGVI@976|Bacteroidetes,2FPGR@200643|Bacteroidia 976|Bacteroidetes EH Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_690078_1 519989.ECTPHS_08773 1.06e-167 487.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales 135613|Chromatiales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_526839_1 1177928.TH2_05808 4.43e-90 274.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TS0W@28211|Alphaproteobacteria,2JQN5@204441|Rhodospirillales 204441|Rhodospirillales S Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_591451_1 338966.Ppro_3716 3.05e-123 358.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42R4P@68525|delta/epsilon subdivisions,2X5AT@28221|Deltaproteobacteria,43W1U@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_591451_2 483219.LILAB_25975 1.01e-55 198.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2Z334@29|Myxococcales 28221|Deltaproteobacteria L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_461570_1 1249627.D779_0402 1.28e-177 510.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales 135613|Chromatiales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_232420_1 439235.Dalk_4862 1.65e-21 91.3 COG1073@1|root,COG1073@2|Bacteria,1QUD5@1224|Proteobacteria,42Q84@68525|delta/epsilon subdivisions,2WP99@28221|Deltaproteobacteria,2MJ53@213118|Desulfobacterales 28221|Deltaproteobacteria S Prolyl oligopeptidase family - - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4 k59_1018212_1 1121405.dsmv_1730 1.54e-40 150.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,42N32@68525|delta/epsilon subdivisions,2WKBN@28221|Deltaproteobacteria,2MI0S@213118|Desulfobacterales 28221|Deltaproteobacteria D PFAM peptidase - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23,SH3_3 k59_463096_1 326298.Suden_0368 5.49e-39 144.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2YMIP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_756190_1 1380394.JADL01000011_gene3942 3.25e-94 288.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TU6U@28211|Alphaproteobacteria,2JPVH@204441|Rhodospirillales 204441|Rhodospirillales E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_103403_1 1168034.FH5T_00810 2.47e-24 102.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,2FNQB@200643|Bacteroidia 976|Bacteroidetes G pectate lyase K01728 - - - - - - - - - - - - - k59_103403_2 1168034.FH5T_00815 2.33e-113 341.0 COG3507@1|root,COG3507@2|Bacteria,4NFXE@976|Bacteroidetes,2FNGR@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family xynBA - - - - - - - - - - - Glyco_hydro_43 k59_265931_1 709032.Sulku_0553 3.41e-153 449.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2YMB3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB1 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_952742_1 1168034.FH5T_04170 1.35e-111 354.0 COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,2FMWR@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_364538_1 1123326.JFBL01000010_gene747 5.33e-97 295.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,42MI1@68525|delta/epsilon subdivisions,2YMPQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Sulfatase eptA - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_364538_2 944547.ABLL_2828 1.07e-93 281.0 COG3907@1|root,COG3907@2|Bacteria,1MY7B@1224|Proteobacteria,42RAC@68525|delta/epsilon subdivisions,2YRS3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PAP2 superfamily - - - - - - - - - - - - PAP2 k59_298686_1 345341.KUTG_00336 1.18e-05 52.4 COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria,4EA1U@85010|Pseudonocardiales 201174|Actinobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_103411_1 1165841.SULAR_00420 1.75e-116 342.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2YN32@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_659163_1 1049564.TevJSym_aw00360 4.88e-45 150.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S2ZH@1236|Gammaproteobacteria,1J8B0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfur oxidation protein SoxY soxY - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_659163_2 765911.Thivi_3139 1.24e-16 74.3 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria,1WYK5@135613|Chromatiales 135613|Chromatiales S PFAM Sulphur oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_625968_1 1279038.KB907355_gene2110 5.87e-54 187.0 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2TSTX@28211|Alphaproteobacteria,2JRHX@204441|Rhodospirillales 204441|Rhodospirillales Q Paraquat-inducible protein B - - - ko:K06192 - - - - ko00000 - - - MlaD k59_691333_1 1123261.AXDW01000001_gene1493 6.58e-98 299.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1X35C@135614|Xanthomonadales 135614|Xanthomonadales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_985399_1 870187.Thini_0022 6.38e-71 220.0 COG3335@1|root,COG3335@2|Bacteria,1NAUU@1224|Proteobacteria 1224|Proteobacteria L PFAM Rhodopirellula transposase - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_789321_1 387093.SUN_2038 1e-61 210.0 COG3920@1|root,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,42PDP@68525|delta/epsilon subdivisions,2YMI8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T two-component sensor histidine kinase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA_2 k59_561071_1 1123237.Salmuc_00331 3.95e-124 366.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG4584 Transposase and inactivated derivatives istA - - - - - - - - - - - rve k59_168982_1 477228.YO5_09355 9.53e-80 259.0 COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG0457 FOG TPR repeat - - - - - - - - - - - - Cytochrom_C552,Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_1,TPR_11,TPR_16,TPR_19,TPR_8 k59_592780_1 519989.ECTPHS_04044 3.13e-43 142.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,1WYVD@135613|Chromatiales 135613|Chromatiales J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_592780_2 765913.ThidrDRAFT_0985 3.7e-175 498.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales 135613|Chromatiales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_592780_3 765911.Thivi_2542 1.29e-187 530.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1WWMC@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_592780_6 153721.MYP_2677 6.43e-31 121.0 2C8XG@1|root,2Z7PK@2|Bacteria,4NEU8@976|Bacteroidetes,47QZN@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_886871_1 870187.Thini_4022 1.17e-20 84.0 COG5420@1|root,COG5420@2|Bacteria,1N98S@1224|Proteobacteria,1SCVR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Uncharacterised protein family UPF0437 - - - - - - - - - - - - Rop-like k59_265958_1 1121935.AQXX01000109_gene475 1.34e-127 376.0 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,1RP2M@1236|Gammaproteobacteria,1XICY@135619|Oceanospirillales 135619|Oceanospirillales S Mo-co oxidoreductase dimerisation domain - - - - - - - - - - - - Mo-co_dimer,Oxidored_molyb k59_920676_1 742725.HMPREF9450_01263 3.38e-123 366.0 COG2407@1|root,COG2407@2|Bacteria,4NF0C@976|Bacteroidetes,2FQMA@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the conversion of L-arabinose to L-ribulose - - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Isome,Fucose_iso_C k59_463144_1 998674.ATTE01000001_gene364 4.1e-83 264.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,460E6@72273|Thiotrichales 72273|Thiotrichales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_626423_2 1165841.SULAR_08407 3.33e-30 115.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,42PIF@68525|delta/epsilon subdivisions,2YQ6W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA,Rick_17kDa_Anti k59_136641_1 1250006.JHZZ01000001_gene650 4.1e-63 206.0 COG3568@1|root,COG3568@2|Bacteria,4NPTN@976|Bacteroidetes,1IG4Y@117743|Flavobacteriia,3VVDU@52959|Polaribacter 976|Bacteroidetes S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_953144_1 1244083.CSUNSWCD_2114 1.29e-29 125.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2YM9V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_822728_1 1249975.JQLP01000005_gene915 5.84e-30 112.0 COG0703@1|root,COG0703@2|Bacteria,4NQ73@976|Bacteroidetes,1I2WH@117743|Flavobacteriia,2P6T8@244698|Gillisia 976|Bacteroidetes E Shikimate kinase aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_921104_1 387093.SUN_2302 7e-46 159.0 COG2378@1|root,COG2378@2|Bacteria,1R65H@1224|Proteobacteria,42QSK@68525|delta/epsilon subdivisions,2YT2U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - WYL k59_921104_2 525373.HMPREF0766_12662 5.71e-18 82.0 COG1502@1|root,COG1502@2|Bacteria,4NK36@976|Bacteroidetes,1IVT5@117747|Sphingobacteriia 976|Bacteroidetes I ORF6N domain - - - - - - - - - - - - ORF6N k59_756601_1 933262.AXAM01000022_gene3241 3.97e-40 152.0 COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales 28221|Deltaproteobacteria IQ TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA - - - - - - - - - - - - Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_789770_1 572544.Ilyop_1744 1.46e-66 203.0 COG3862@1|root,COG3862@2|Bacteria,37ADI@32066|Fusobacteria 32066|Fusobacteria S protein with conserved CXXC pairs - - - - - - - - - - - - DUF1667 k59_789770_2 572544.Ilyop_1739 2.3e-13 68.9 COG0446@1|root,COG0446@2|Bacteria,378BM@32066|Fusobacteria 32066|Fusobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_3 k59_593268_1 387092.NIS_1112 1.08e-159 454.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42NYX@68525|delta/epsilon subdivisions,2YMSE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Glycosyl transferase family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_593268_2 387092.NIS_1113 8.8e-31 117.0 COG0392@1|root,COG0392@2|Bacteria,1Q9BC@1224|Proteobacteria,434AC@68525|delta/epsilon subdivisions,2YS0P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_921105_1 1408473.JHXO01000002_gene3827 4.26e-25 97.4 COG3439@1|root,COG3439@2|Bacteria,4PB0E@976|Bacteroidetes,2FY5F@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_921105_2 1168034.FH5T_19045 1.48e-73 223.0 COG1765@1|root,COG1765@2|Bacteria,4NNTY@976|Bacteroidetes,2FU46@200643|Bacteroidia 976|Bacteroidetes O OsmC-like protein - - - ko:K07397 - - - - ko00000 - - - OsmC k59_921105_3 1168034.FH5T_19050 0.000105 43.9 COG3118@1|root,COG3118@2|Bacteria,4NWFX@976|Bacteroidetes,2FUZC@200643|Bacteroidia 976|Bacteroidetes O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_495842_1 1255043.TVNIR_0254 2.64e-40 144.0 COG1075@1|root,COG1075@2|Bacteria 2|Bacteria KLT acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - ko:K09384 - - - - ko00000 - - - Abhydrolase_8,PGAP1 k59_169528_1 929558.SMGD1_2362 5.73e-23 101.0 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,42R3P@68525|delta/epsilon subdivisions,2YPBM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COGs COG2829 Outer membrane phospholipase A - - 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - PLA1 k59_169528_2 1172190.M947_07125 2.25e-61 196.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42R9F@68525|delta/epsilon subdivisions,2YNVJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_659630_1 292415.Tbd_2174 1.62e-23 104.0 COG3278@1|root,COG3278@2|Bacteria,1P8T0@1224|Proteobacteria,2VNAW@28216|Betaproteobacteria,1KRQW@119069|Hydrogenophilales 119069|Hydrogenophilales O Belongs to the heme-copper respiratory oxidase family - - - - - - - - - - - - - k59_985872_1 1269813.ATUL01000023_gene658 6.88e-112 334.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_429717_1 983545.Glaag_2666 5.91e-47 173.0 COG3292@1|root,COG5001@1|root,COG3292@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,465AJ@72275|Alteromonadaceae 1236|Gammaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9,Reg_prop,Y_Y_Y k59_37629_2 572544.Ilyop_0810 8.45e-34 120.0 COG1898@1|root,COG1898@2|Bacteria,379FK@32066|Fusobacteria 2|Bacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose - - 4.2.1.46,5.1.3.13 ko:K01710,ko:K01790 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513,R06514 RC00402,RC01531 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd,dTDP_sugar_isom k59_1018780_2 765913.ThidrDRAFT_3506 7.33e-43 143.0 COG2010@1|root,COG2010@2|Bacteria,1NDHN@1224|Proteobacteria,1S700@1236|Gammaproteobacteria,1WYGG@135613|Chromatiales 135613|Chromatiales C Planctomycete cytochrome C - - - - - - - - - - - - PSCyt1 k59_659634_1 632292.Calhy_2458 4.41e-31 119.0 COG0644@1|root,COG0644@2|Bacteria,1UZT1@1239|Firmicutes,25DJ8@186801|Clostridia 186801|Clostridia C oxidoreductase cbrA - - - - - - - - - - - FAD_binding_3,Lycopene_cycl,NAD_binding_8 k59_659634_2 1165841.SULAR_07093 3.17e-127 369.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2YMV6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_953158_1 641491.DND132_2717 1.95e-151 446.0 COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria,2M9NW@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM natural resistance-associated macrophage protein mntH - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp,Usp k59_593279_1 326298.Suden_0768 1.63e-71 227.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42RAU@68525|delta/epsilon subdivisions,2YPXZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_365102_1 556268.OFAG_01887 6.32e-154 439.0 28MZW@1|root,2ZB6I@2|Bacteria,1RCF3@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_921123_1 314225.ELI_14900 1.63e-133 385.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_659641_1 1304880.JAGB01000001_gene773 5.29e-45 159.0 COG3325@1|root,COG3325@2|Bacteria,1UK1U@1239|Firmicutes,25B7D@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 18 family - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - Glyco_hydro_18 k59_70694_1 1500893.JQNB01000001_gene1518 7.8e-49 163.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1X2XT@135614|Xanthomonadales 135614|Xanthomonadales KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_724359_1 640081.Dsui_2419 5.78e-12 72.8 COG3283@1|root,COG5001@1|root,COG3283@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJCN@28216|Betaproteobacteria,2KVW5@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4,dCache_1 k59_822766_1 713586.KB900536_gene530 1.81e-15 72.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM PEBP family protein ybhB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044424,GO:0044464 - ko:K06910 - - - - ko00000 - - - PBP k59_626428_1 888055.HMPREF9015_00350 6.99e-44 144.0 COG0199@1|root,COG0199@2|Bacteria,37AF7@32066|Fusobacteria 32066|Fusobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_626428_2 1095747.HMPREF1049_1710 6.78e-75 225.0 COG0096@1|root,COG0096@2|Bacteria,379ZT@32066|Fusobacteria 32066|Fusobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_626428_3 572544.Ilyop_1795 1.6e-93 276.0 COG0097@1|root,COG0097@2|Bacteria,3784U@32066|Fusobacteria 32066|Fusobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_626428_4 1278306.KB906913_gene968 4.84e-57 179.0 COG0256@1|root,COG0256@2|Bacteria,37ADG@32066|Fusobacteria 32066|Fusobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_626428_5 1319815.HMPREF0202_01282 2.6e-82 247.0 COG0098@1|root,COG0098@2|Bacteria,378R5@32066|Fusobacteria 32066|Fusobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_626428_6 572544.Ilyop_1792 1.01e-25 95.9 COG1841@1|root,COG1841@2|Bacteria,37B10@32066|Fusobacteria 32066|Fusobacteria J Ribosomal protein L30p/L7e rpmD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_626428_7 1319815.HMPREF0202_01284 9.08e-66 204.0 COG0200@1|root,COG0200@2|Bacteria,379T1@32066|Fusobacteria 32066|Fusobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_626428_8 572544.Ilyop_1790 1.14e-245 682.0 COG0201@1|root,COG0201@2|Bacteria,37900@32066|Fusobacteria 32066|Fusobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_626428_9 572544.Ilyop_1789 4.77e-133 379.0 COG0563@1|root,COG0563@2|Bacteria,378CT@32066|Fusobacteria 32066|Fusobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_626428_10 469616.FMAG_02354 1.77e-128 371.0 COG0024@1|root,COG0024@2|Bacteria,378RV@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_626428_11 190304.FN1287 8.93e-41 135.0 COG0361@1|root,COG0361@2|Bacteria,37AMF@32066|Fusobacteria 32066|Fusobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_626428_12 861452.HMPREF9093_00974 9.03e-67 204.0 COG0099@1|root,COG0099@2|Bacteria,37A4B@32066|Fusobacteria 32066|Fusobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_626428_13 1319815.HMPREF0202_01290 7.11e-74 223.0 COG0100@1|root,COG0100@2|Bacteria,379Y9@32066|Fusobacteria 32066|Fusobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_626428_14 572544.Ilyop_1783 8.47e-109 316.0 COG0522@1|root,COG0522@2|Bacteria,3787F@32066|Fusobacteria 32066|Fusobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_626428_15 1319815.HMPREF0202_01292 5.85e-176 497.0 COG0202@1|root,COG0202@2|Bacteria,3791W@32066|Fusobacteria 32066|Fusobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_626428_16 572544.Ilyop_1781 2.51e-63 195.0 COG0203@1|root,COG0203@2|Bacteria,37A4I@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_528930_1 1121912.AUHD01000001_gene2803 5.11e-06 45.8 COG1544@1|root,COG1544@2|Bacteria,4NSC5@976|Bacteroidetes,1I458@117743|Flavobacteriia 976|Bacteroidetes J Sigma 54 modulation protein / S30EA ribosomal protein - - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_528930_2 1197477.IA57_02300 3.59e-42 147.0 2DBPI@1|root,2ZA97@2|Bacteria,4NKIQ@976|Bacteroidetes,1HZAT@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4421) - - - - - - - - - - - - DUF4421 k59_1019855_6 469616.FMAG_02389 8.31e-05 49.3 28IJ0@1|root,2Z8JZ@2|Bacteria,379QF@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - - k59_398711_1 1122604.JONR01000032_gene99 2.58e-14 77.8 COG0457@1|root,COG0457@2|Bacteria,1Q7UR@1224|Proteobacteria,1T5SX@1236|Gammaproteobacteria,1XDF7@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_823804_1 713586.KB900536_gene3003 1.35e-14 73.6 COG1716@1|root,COG1716@2|Bacteria,1PGN8@1224|Proteobacteria,1SEK2@1236|Gammaproteobacteria 1236|Gammaproteobacteria T FHA domain - - - - - - - - - - - - FHA,Yop-YscD_cpl k59_823804_2 1042377.AFPJ01000035_gene2638 1.49e-18 83.2 29B18@1|root,2ZY02@2|Bacteria,1REMG@1224|Proteobacteria,1S4B1@1236|Gammaproteobacteria,46AUF@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_692965_1 1165841.SULAR_08227 4.95e-79 252.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,42MA2@68525|delta/epsilon subdivisions,2YNPU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S L,D-transpeptidase catalytic domain - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_856511_1 1168034.FH5T_03600 3.53e-219 614.0 COG0488@1|root,COG0488@2|Bacteria,4NF6E@976|Bacteroidetes,2FNX4@200643|Bacteroidia 976|Bacteroidetes S ATPase components of ABC transporters with duplicated ATPase domains - - - - - - - - - - - - ABC_tran k59_38442_1 1121937.AUHJ01000008_gene2056 6.23e-19 88.6 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,4673B@72275|Alteromonadaceae 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_38442_2 211586.SO_0292 2.73e-14 70.1 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,2Q9J2@267890|Shewanellaceae 1236|Gammaproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0155,iYL1228.KPN_03757 Ribul_P_3_epim k59_627731_2 387093.SUN_2277 5.29e-54 176.0 COG0666@1|root,COG0666@2|Bacteria,1Q2UY@1224|Proteobacteria,42WAJ@68525|delta/epsilon subdivisions,2YQKP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ankyrin repeat - - - - - - - - - - - - Ank_2,Ank_4,Ank_5 k59_137862_1 1168034.FH5T_06085 1.28e-108 317.0 COG0730@1|root,COG0730@2|Bacteria,4NH6M@976|Bacteroidetes,2FSUD@200643|Bacteroidia 976|Bacteroidetes S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_660857_1 1340493.JNIF01000004_gene1118 2.15e-54 183.0 COG2230@1|root,COG2230@2|Bacteria 2|Bacteria M cyclopropane-fatty-acyl-phospholipid synthase cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_627735_1 566466.NOR53_3532 1.13e-128 374.0 COG3386@1|root,COG3386@2|Bacteria,1QN8Y@1224|Proteobacteria,1S5PU@1236|Gammaproteobacteria,1J7F2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G SMP-30/Gluconolaconase/LRE-like region - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL k59_954199_1 553218.CAMRE0001_2300 2.98e-10 63.2 COG3291@1|root,COG3291@2|Bacteria,1R0W2@1224|Proteobacteria,43D27@68525|delta/epsilon subdivisions,2YTFR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF1566) - - - - - - - - - - - - DUF1566 k59_954199_2 1250005.PHEL85_0181 2.93e-13 73.6 COG1234@1|root,COG1262@1|root,COG1234@2|Bacteria,COG1262@2|Bacteria,4NGWF@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF1566) - - - - - - - - - - - - DUF1566,Lactamase_B_2 k59_757867_2 243090.RB2975 1.81e-40 137.0 COG0347@1|root,COG0347@2|Bacteria,2IZZ9@203682|Planctomycetes 203682|Planctomycetes K Belongs to the P(II) protein family - - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_757867_3 572544.Ilyop_0887 2.25e-226 634.0 COG0004@1|root,COG0004@2|Bacteria,37ANZ@32066|Fusobacteria 2|Bacteria P Ammonium Transporter Family amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,P-II k59_202588_1 1185652.USDA257_c10720 7.15e-28 114.0 2AKF7@1|root,31B6Q@2|Bacteria,1N34J@1224|Proteobacteria,2UDT6@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_202588_2 387093.SUN_1826 2.28e-28 112.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42QFD@68525|delta/epsilon subdivisions,2YND7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FP Ppx GppA - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_72097_1 265072.Mfla_2297 4.57e-26 108.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,2KKRZ@206350|Nitrosomonadales 206350|Nitrosomonadales H PFAM MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_267898_1 237368.SCABRO_01963 7.02e-52 176.0 2DDQR@1|root,2ZIXJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_563204_1 765912.Thimo_0056 1.17e-33 125.0 COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1WWJP@135613|Chromatiales 135613|Chromatiales S Sterol-binding domain protein - - - ko:K03690 - - - - ko00000 - - - SCP2 k59_366943_2 765912.Thimo_0797 6.25e-92 276.0 29137@1|root,2ZNQP@2|Bacteria,1NWTW@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_725940_1 469616.FMAG_02429 6.25e-69 241.0 28HN5@1|root,2Z7WI@2|Bacteria,37876@32066|Fusobacteria 32066|Fusobacteria S Replication initiator protein A - - - - - - - - - - - - RPA k59_530647_1 439235.Dalk_4848 4.28e-96 299.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria 28221|Deltaproteobacteria C acyl-coa dehydrogenase - - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_203195_1 563040.Saut_1913 1.58e-61 200.0 2AIIS@1|root,3190V@2|Bacteria,1Q1CZ@1224|Proteobacteria,42TB4@68525|delta/epsilon subdivisions,2YPN5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_954598_1 1168034.FH5T_17585 7.58e-101 313.0 COG2304@1|root,COG2304@2|Bacteria,4NER3@976|Bacteroidetes,2FW70@200643|Bacteroidia 976|Bacteroidetes S oxidoreductase activity - - - - - - - - - - - - - k59_922893_1 396588.Tgr7_3246 1.7e-126 392.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WX2G@135613|Chromatiales 135613|Chromatiales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_1020364_1 1336234.JAGN01000011_gene211 5.29e-34 130.0 COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,4HCYI@91061|Bacilli,27HPP@186828|Carnobacteriaceae 91061|Bacilli G 2,3-bisphosphoglycerate-independent phosphoglycerate mutase - - - - - - - - - - - - Metalloenzyme,PhosphMutase k59_267902_1 929558.SMGD1_1251 4.49e-36 124.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,42RDZ@68525|delta/epsilon subdivisions,2YP5I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_267902_2 1537917.JU82_05020 8.02e-48 171.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,42M47@68525|delta/epsilon subdivisions,2YMRS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T (EAL) domain protein - - - - - - - - - - - - EAL,GGDEF k59_758454_2 457396.CSBG_02627 2.93e-56 194.0 COG0492@1|root,COG3634@1|root,COG0492@2|Bacteria,COG3634@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,36E0J@31979|Clostridiaceae 186801|Clostridia C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB1 - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_758454_3 702450.CUW_1608 3.14e-107 311.0 COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,3VP0W@526524|Erysipelotrichia 526524|Erysipelotrichia O Peroxiredoxin ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_758454_4 926561.KB900618_gene311 6.83e-259 741.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_431337_1 1301098.PKB_0952 5.65e-12 69.7 COG2365@1|root,COG2365@2|Bacteria,1RGE7@1224|Proteobacteria,1SCH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Tyrosine phosphatase family - - - - - - - - - - - - DSPc,Y_phosphatase2,Y_phosphatase3 k59_366954_1 1510531.JQJJ01000008_gene3743 6.89e-05 51.2 COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TVPK@28211|Alphaproteobacteria,3JSM7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Major Facilitator Superfamily MA20_09740 - - - - - - - - - - - MFS_1 k59_693585_1 1172190.M947_01210 2.78e-31 116.0 2AJE1@1|root,319ZU@2|Bacteria,1Q4J6@1224|Proteobacteria,42U7R@68525|delta/epsilon subdivisions,2YQ63@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_758461_1 1249627.D779_3939 8.67e-61 197.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_497840_1 572477.Alvin_1220 9.8e-53 171.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1WYI3@135613|Chromatiales 135613|Chromatiales S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_725951_1 1168034.FH5T_05795 2.72e-56 195.0 COG3250@1|root,COG3250@2|Bacteria,4NKZX@976|Bacteroidetes,2FNTC@200643|Bacteroidia 976|Bacteroidetes G Beta galactosidase small chain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3 k59_725951_2 143224.JQMD01000002_gene1615 8.41e-111 333.0 COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,1HX8I@117743|Flavobacteriia 976|Bacteroidetes P Arylsulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_922911_1 1255043.TVNIR_2802 3.66e-141 405.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1WZWK@135613|Chromatiales 135613|Chromatiales G pfkB family carbohydrate kinase - - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_1020380_1 761193.Runsl_0369 1.98e-88 286.0 COG2866@1|root,COG2866@2|Bacteria,4NGIE@976|Bacteroidetes,47N2M@768503|Cytophagia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_300690_1 1168065.DOK_05245 3.25e-171 486.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1J946@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_465260_1 1336243.JAEA01000006_gene314 1.03e-111 345.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2U0IK@28211|Alphaproteobacteria,1JSZW@119045|Methylobacteriaceae 28211|Alphaproteobacteria O Lon protease (S16) C-terminal proteolytic domain MA20_45155 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_497844_1 1121289.JHVL01000039_gene3139 2.79e-17 76.6 COG2030@1|root,COG2030@2|Bacteria,1V6MY@1239|Firmicutes,24NB6@186801|Clostridia,36M8N@31979|Clostridiaceae 186801|Clostridia I PFAM MaoC domain protein dehydratase - - 4.2.1.55 ko:K17865 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R03027 RC00831 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas k59_497844_2 1278306.KB906907_gene72 4.67e-205 575.0 COG1960@1|root,COG1960@2|Bacteria,378TZ@32066|Fusobacteria 32066|Fusobacteria C Acyl-CoA dehydrogenase, N-terminal domain bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_693600_1 870187.Thini_1586 1.44e-77 241.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,460B1@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF455) - - - - - - - - - - - - DUF455 k59_334678_1 29730.Gorai.007G237900.1 9.26e-06 43.9 2EQ7X@1|root,2ST9U@2759|Eukaryota,3819J@33090|Viridiplantae,3GQNF@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_661457_1 1168034.FH5T_04380 1e-112 334.0 COG0686@1|root,COG0686@2|Bacteria,4NF46@976|Bacteroidetes,2FW97@200643|Bacteroidia 976|Bacteroidetes E Alanine dehydrogenase/PNT, N-terminal domain - - - - - - - - - - - - AlaDh_PNT_C,AlaDh_PNT_N k59_628400_1 1304885.AUEY01000004_gene1018 1.76e-18 88.2 COG1729@1|root,COG1729@2|Bacteria,1QU1J@1224|Proteobacteria,4396Z@68525|delta/epsilon subdivisions,2X4DT@28221|Deltaproteobacteria,2MMUS@213118|Desulfobacterales 28221|Deltaproteobacteria S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - - - - - - - - - - - k59_267914_2 1353529.M899_2028 2.05e-101 335.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42Q10@68525|delta/epsilon subdivisions,2WM5I@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Domain of unknown function (DUF3372) - - 3.2.1.41 ko:K01200 ko00500,ko01100,ko01110,map00500,map01100,map01110 - R02111 - ko00000,ko00001,ko01000 - CBM48,GH13 - CBM_48,DUF3372 k59_563246_1 1168034.FH5T_10680 2.91e-97 297.0 COG2509@1|root,COG2509@2|Bacteria,4NEUQ@976|Bacteroidetes,2FM1G@200643|Bacteroidia 976|Bacteroidetes S Psort location Cytoplasmic, score - - - ko:K07137 - - - - ko00000 - - - FAD_binding_2,FAD_binding_3,GIDA,HI0933_like,Pyr_redox_2 k59_334692_1 251221.35210571 2.41e-102 302.0 COG1117@1|root,COG1117@2|Bacteria,1G0P6@1117|Cyanobacteria 1117|Cyanobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system - - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_300711_1 768671.ThimaDRAFT_2371 9.76e-37 129.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales 135613|Chromatiales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_300711_2 582744.Msip34_0182 6.19e-08 55.1 COG0322@1|root,COG0758@1|root,COG0322@2|Bacteria,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,2KKV6@206350|Nitrosomonadales 206350|Nitrosomonadales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_530697_1 891974.E05_50940 2.52e-25 96.7 COG3414@1|root,COG3414@2|Bacteria,1RHBP@1224|Proteobacteria,1S5Y7@1236|Gammaproteobacteria 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport gatB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015791,GO:0015796,GO:0015850,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090584 2.7.1.200 ko:K02774 ko00052,ko01100,ko02060,map00052,map01100,map02060 M00279 R05570 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.5.1 - iB21_1397.B21_01985,iECABU_c1320.ECABU_c24230,iECBD_1354.ECBD_1564,iECB_1328.ECB_02019,iECD_1391.ECD_02019,iECH74115_1262.ECH74115_3072,iECSP_1301.ECSP_2888,iECW_1372.ECW_m2294,iECs_1301.ECs2896,iEKO11_1354.EKO11_1661,iEcSMS35_1347.EcSMS35_0971,iSF_1195.SF2155,iSFxv_1172.SFxv_2384,iS_1188.S2281,iWFL_1372.ECW_m2294,iZ_1308.Z3256,ic_1306.c2618 PTS_IIB k59_530697_2 1397284.AYMN01000006_gene1254 7.17e-46 160.0 COG3775@1|root,COG3775@2|Bacteria,1MVRC@1224|Proteobacteria,1RQ76@1236|Gammaproteobacteria,404WR@613|Serratia 1236|Gammaproteobacteria G PTS system sugar-specific permease component gatC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015791,GO:0015796,GO:0015850,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090584 - ko:K02775 ko00052,ko01100,ko02060,map00052,map01100,map02060 M00279 R05570 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.5.1 - iEcolC_1368.EcolC_1555,iYL1228.KPN_03550 EIIC-GAT k59_628414_1 765912.Thimo_0707 1.54e-61 207.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_628415_1 387093.SUN_2355 6.2e-52 173.0 COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1N0EE@1224|Proteobacteria,42V3C@68525|delta/epsilon subdivisions,2YQCX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M NlpC/P60 family - - 3.4.17.13 ko:K13694,ko:K13695 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,SPOR k59_497873_1 713587.THITH_06840 7.36e-100 300.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1WWD8@135613|Chromatiales 135613|Chromatiales O Belongs to the HypD family - - - ko:K04654 - - - - ko00000 - - - HypD k59_235989_1 1168034.FH5T_07025 1.07e-72 245.0 COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,2FM0P@200643|Bacteroidia 976|Bacteroidetes G beta-galactosidase - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_693639_1 697282.Mettu_3452 1.02e-56 201.0 COG3387@1|root,COG3387@2|Bacteria,1MXWR@1224|Proteobacteria,1RRAC@1236|Gammaproteobacteria,1XEWG@135618|Methylococcales 135618|Methylococcales G Glycosyl hydrolases family 15 - - - ko:K07190 ko04020,ko04910,ko04922,map04020,map04910,map04922 - - - ko00000,ko00001 - - - Glyco_hydro_15 k59_758517_1 563040.Saut_0706 3.57e-133 389.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2YMBS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_661485_1 929558.SMGD1_0558 2.98e-124 374.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit frdA - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_725993_1 765912.Thimo_1086 4.34e-78 246.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales 135613|Chromatiales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_530718_1 1168034.FH5T_10605 3.41e-37 137.0 COG3087@1|root,COG3087@2|Bacteria,4NF9U@976|Bacteroidetes 976|Bacteroidetes D sporulation - - - - - - - - - - - - SPOR k59_334716_1 1123514.KB905903_gene366 4.83e-43 158.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,1RSM7@1236|Gammaproteobacteria,461T0@72273|Thiotrichales 72273|Thiotrichales S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_267936_1 563040.Saut_0303 6.09e-82 259.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2YMEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_563272_1 61459.XP_007780395.1 2.58e-06 50.1 2D09G@1|root,2S4T9@2759|Eukaryota,39Q50@33154|Opisthokonta,3Q6B4@4751|Fungi,3RPAQ@4890|Ascomycota 4751|Fungi - - - - - - - - - - - - - - - k59_105844_1 631362.Thi970DRAFT_01611 8.47e-77 245.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_4617_2 204669.Acid345_4155 1.25e-19 90.1 COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia 204432|Acidobacteriia KU Transcriptional regulatory protein, C terminal - - - - - - - - - - - - PD40,Trans_reg_C k59_236005_1 545276.KB898725_gene822 1.48e-70 228.0 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1WWKK@135613|Chromatiales 135613|Chromatiales O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_267944_1 1121935.AQXX01000090_gene3857 1.32e-67 222.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1XHA4@135619|Oceanospirillales 135619|Oceanospirillales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_465310_1 1223410.KN050846_gene2762 1.91e-05 45.8 COG0381@1|root,COG0381@2|Bacteria,4NFTG@976|Bacteroidetes,1HZTF@117743|Flavobacteriia 976|Bacteroidetes M UDP-N-acetylglucosamine 2-epimerase neuC - 3.2.1.183,3.2.1.184 ko:K08068,ko:K18429 ko00520,map00520 - R10187 RC00005,RC00288 ko00000,ko00001,ko01000 - - - Epimerase_2 k59_465310_2 1086011.HJ01_00271 4.27e-87 264.0 COG1083@1|root,COG1083@2|Bacteria,4NM98@976|Bacteroidetes,1I17Z@117743|Flavobacteriia,2NSYX@237|Flavobacterium 976|Bacteroidetes M Acylneuraminate cytidylyltransferase - - 2.7.7.43 ko:K00983 ko00520,ko01100,map00520,map01100 - R01117,R04215 RC00152 ko00000,ko00001,ko01000 - - - CTP_transf_3 k59_465310_3 1146883.BLASA_0342 3.67e-11 64.3 COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4ERY2@85013|Frankiales 201174|Actinobacteria E asparagine - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_563281_1 459495.SPLC1_S090240 8.05e-63 206.0 COG1397@1|root,COG1397@2|Bacteria,1GI84@1117|Cyanobacteria,1HEJK@1150|Oscillatoriales 1117|Cyanobacteria O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_138595_1 1249480.B649_04625 2.95e-74 235.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,42NYD@68525|delta/epsilon subdivisions,2YNI5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Permease, YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_530731_1 398720.MED217_01770 2.08e-39 137.0 COG1738@1|root,COG1738@2|Bacteria,4NFP3@976|Bacteroidetes,1HYC6@117743|Flavobacteriia,2XHVY@283735|Leeuwenhoekiella 976|Bacteroidetes S Putative vitamin uptake transporter - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_987868_1 526218.Sterm_0174 1.06e-30 120.0 COG0621@1|root,COG0621@2|Bacteria,378WY@32066|Fusobacteria 32066|Fusobacteria J Uncharacterized protein family UPF0004 yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_987868_2 1408439.JHXW01000009_gene351 1.91e-24 102.0 2C6M6@1|root,2Z7KD@2|Bacteria,378X7@32066|Fusobacteria 32066|Fusobacteria - - - - - - - - - - - - - - LytR_C k59_433114_1 395493.BegalDRAFT_2956 8.76e-10 62.0 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,1RSEU@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the phosphoglycerate mutase family gpmB - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5997 His_Phos_1 k59_433114_2 1227268.HMPREF1552_01817 1.44e-158 453.0 COG0113@1|root,COG0113@2|Bacteria,37903@32066|Fusobacteria 32066|Fusobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_433114_3 1410633.JHWR01000014_gene1746 3.19e-36 143.0 COG2099@1|root,COG2241@1|root,COG2242@1|root,COG2099@2|Bacteria,COG2241@2|Bacteria,COG2242@2|Bacteria,1TS3H@1239|Firmicutes,2483G@186801|Clostridia,27JAF@186928|unclassified Lachnospiraceae 186801|Clostridia H Precorrin-6Y C5,15-methyltransferase (Decarboxylating), CbiT subunit cbiT - 2.1.1.132,2.1.1.196 ko:K00595,ko:K02191 ko00860,ko01100,map00860,map01100 - R05149,R05813,R07774 RC00003,RC01279,RC02052,RC02054 ko00000,ko00001,ko01000 - - - CbiJ,Cons_hypoth95,MTS,Met_10,Methyltransf_31,Methyltransf_4,PCMT,TP_methylase k59_433114_4 1410620.SHLA_32c000860 1.52e-55 188.0 COG1879@1|root,COG1879@2|Bacteria,1MWGU@1224|Proteobacteria,2U2E3@28211|Alphaproteobacteria,4B79Y@82115|Rhizobiaceae 28211|Alphaproteobacteria G ABC-type sugar transport system, periplasmic component mglB - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_237746_1 269799.Gmet_2565 1.36e-49 169.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria 28221|Deltaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_400883_1 1457250.BBMO01000002_gene2086 9.33e-09 62.4 COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,23T72@183963|Halobacteria 183963|Halobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_74806_1 1121405.dsmv_2158 2.94e-48 159.0 29HYV@1|root,304VW@2|Bacteria,1RDPY@1224|Proteobacteria,42RXW@68525|delta/epsilon subdivisions,2WNTT@28221|Deltaproteobacteria,2MJZ3@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_433122_1 314278.NB231_08485 3.26e-75 248.0 COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,1WWAJ@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c k59_727580_1 1408439.JHXW01000004_gene1271 3.15e-44 152.0 COG0502@1|root,COG0502@2|Bacteria,379PA@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_107709_4 1163671.JAGI01000001_gene321 2.43e-101 315.0 COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,248XN@186801|Clostridia,36FC0@31979|Clostridiaceae 186801|Clostridia J L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp aspS - 6.1.1.12,6.1.1.23 ko:K01876,ko:K09759 ko00970,map00970 M00359,M00360 R03647,R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - tRNA-synt_2,tRNA_anti-codon k59_269612_1 909663.KI867150_gene630 5.56e-41 147.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2WK12@28221|Deltaproteobacteria 28221|Deltaproteobacteria C electron transfer flavoprotein, alpha subunit - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_205340_1 933262.AXAM01000079_gene2205 1e-40 140.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2WJ1Z@28221|Deltaproteobacteria,2MHWH@213118|Desulfobacterales 28221|Deltaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_205340_2 1121405.dsmv_3649 1.43e-78 235.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2WNAH@28221|Deltaproteobacteria,2MJXQ@213118|Desulfobacterales 28221|Deltaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_956392_1 66377.JOBH01000001_gene1507 4.68e-51 183.0 COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria 201174|Actinobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_760028_1 1121405.dsmv_2407 3.43e-95 293.0 COG3635@1|root,COG3635@2|Bacteria,1R2SD@1224|Proteobacteria,42NR6@68525|delta/epsilon subdivisions,2WJZY@28221|Deltaproteobacteria,2MIXZ@213118|Desulfobacterales 28221|Deltaproteobacteria G TIGRFAM phosphonopyruvate decarboxylase-related protein - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_172953_1 435908.IDSA_01430 6.4e-164 474.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,2QG08@267893|Idiomarinaceae 1236|Gammaproteobacteria U POT family - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_368955_1 1128421.JAGA01000002_gene1834 9.2e-31 120.0 COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria 2|Bacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_368955_3 997346.HMPREF9374_2285 7.88e-127 386.0 COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,4HB81@91061|Bacilli,27B5T@186824|Thermoactinomycetaceae 91061|Bacilli L Ultra-violet resistance protein B uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_695302_2 1396141.BATP01000058_gene2064 1.04e-36 131.0 COG1051@1|root,COG1051@2|Bacteria,46VKY@74201|Verrucomicrobia,2IUH7@203494|Verrucomicrobiae 203494|Verrucomicrobiae F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_891154_1 385682.AFSL01000063_gene1537 8.97e-100 302.0 COG0541@1|root,COG0541@2|Bacteria,4NDZ2@976|Bacteroidetes,2FNSI@200643|Bacteroidia,3XIQ8@558415|Marinilabiliaceae 976|Bacteroidetes U SRP54-type protein, GTPase domain ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_467008_1 1121904.ARBP01000035_gene1764 5.71e-111 352.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,47YHX@768503|Cytophagia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_400913_1 1121957.ATVL01000012_gene853 3.25e-121 355.0 COG1621@1|root,COG1621@2|Bacteria,4NJYV@976|Bacteroidetes,47XB9@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_32N,Glyco_hydro_43 k59_302410_1 472759.Nhal_3703 1.69e-20 89.7 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1WW1H@135613|Chromatiales 135613|Chromatiales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_302410_2 521719.ATXQ01000001_gene500 3.88e-30 115.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1YCV3@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3924,iPC815.YPO3501 Pterin_bind k59_336813_1 1319815.HMPREF0202_00053 6.38e-07 50.8 COG0709@1|root,COG0709@2|Bacteria,379T4@32066|Fusobacteria 32066|Fusobacteria H Selenide, water dikinase selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k59_336813_2 445973.CLOBAR_00276 1.05e-67 213.0 COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,24JW8@186801|Clostridia,25RGG@186804|Peptostreptococcaceae 186801|Clostridia O Belongs to the sulfur carrier protein TusA family yedF - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE,TusA k59_989853_1 1380391.JIAS01000017_gene548 1.6e-59 187.0 COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2U70I@28211|Alphaproteobacteria,2JS83@204441|Rhodospirillales 204441|Rhodospirillales P Belongs to the bacterioferritin family bfr - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_336815_1 1267600.JFGT01000005_gene2617 3.16e-58 193.0 COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,1RN4R@1236|Gammaproteobacteria,3W1ME@53335|Pantoea 1236|Gammaproteobacteria C Iron-sulfur cluster-binding domain aslB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_336815_2 913325.N799_07380 2.46e-28 115.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1XBWN@135614|Xanthomonadales 135614|Xanthomonadales S M61 glycyl aminopeptidase - - - - - - - - - - - - Peptidase_M61 k59_956421_1 1249480.B649_10740 1.58e-98 296.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2YMZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_532739_1 572544.Ilyop_0520 4.96e-270 754.0 COG0556@1|root,COG0556@2|Bacteria,3783F@32066|Fusobacteria 32066|Fusobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_500014_1 1249480.B649_11675 1.48e-135 393.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,42MF9@68525|delta/epsilon subdivisions,2YN3Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0005488,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0663 Chorismate_synt k59_500014_2 1172190.M947_05355 8.94e-34 122.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,42MIP@68525|delta/epsilon subdivisions,2YMPW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_891176_1 555779.Dthio_PD0909 5.21e-60 201.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria,2M904@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM magnesium chelatase ChlI subunit comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_695322_1 861299.J421_4514 4.28e-39 149.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - BetaGal_dom4_5,Glyco_hydro_2_N,SASA k59_791858_2 177437.HRM2_03740 4.92e-70 217.0 COG1131@1|root,COG1131@2|Bacteria,1MXHE@1224|Proteobacteria,42PFF@68525|delta/epsilon subdivisions 1224|Proteobacteria V ABC transporter, ATP-binding protein nosF - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_695324_1 1249480.B649_03985 5.18e-09 62.8 2AN97@1|root,32J0R@2|Bacteria,1PCA3@1224|Proteobacteria,42T7U@68525|delta/epsilon subdivisions,2YPPF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - Flg_hook k59_956435_1 519989.ECTPHS_11010 2.48e-110 333.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales 135613|Chromatiales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_663427_1 1267533.KB906736_gene961 3.96e-47 154.0 COG1725@1|root,COG1725@2|Bacteria,3Y5VN@57723|Acidobacteria,2JK5T@204432|Acidobacteriia 2|Bacteria K helix_turn_helix gluconate operon transcriptional repressor ytrA - - ko:K07979 - - - - ko00000,ko03000 - - - GntR k59_302418_1 572544.Ilyop_0462 1.8e-64 199.0 COG0219@1|root,COG0219@2|Bacteria,379Z3@32066|Fusobacteria 32066|Fusobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily - - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_302418_2 946235.CAER01000060_gene3265 6.35e-39 164.0 COG0642@1|root,COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1UMIM@1239|Firmicutes,4ITVY@91061|Bacilli 91061|Bacilli T 7TM diverse intracellular signalling - - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Response_reg k59_760063_1 1120919.AUBI01000031_gene2274 2.15e-35 134.0 COG0494@1|root,COG0494@2|Bacteria,1RAFY@1224|Proteobacteria,2U66M@28211|Alphaproteobacteria,2JPXF@204441|Rhodospirillales 204441|Rhodospirillales L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - DUF4743,NUDIX k59_107756_1 887062.HGR_07361 1.06e-13 79.0 COG0457@1|root,COG0457@2|Bacteria,1NNCT@1224|Proteobacteria,2VK0Z@28216|Betaproteobacteria,4ACBW@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg,TPR_16,TPR_19,TPR_8 k59_368987_1 515635.Dtur_0873 9.84e-116 367.0 COG2804@1|root,COG2804@2|Bacteria 2|Bacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_1022353_1 991.IW20_08910 1.45e-29 109.0 COG3118@1|root,COG3118@2|Bacteria,4NSE6@976|Bacteroidetes,1I47G@117743|Flavobacteriia,2NWTE@237|Flavobacterium 976|Bacteroidetes O general stress protein ytxJ - - - - - - - - - - - DUF2847 k59_1022353_2 376686.Fjoh_2151 3.1e-13 70.1 COG0457@1|root,COG0457@2|Bacteria,4NF0N@976|Bacteroidetes,1HWJF@117743|Flavobacteriia,2NSAD@237|Flavobacterium 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - - k59_760066_1 329726.AM1_6037 2.49e-84 261.0 COG3547@1|root,COG3547@2|Bacteria,1G1N1@1117|Cyanobacteria 1117|Cyanobacteria L Transposase is116 is110 is902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_826207_1 1120966.AUBU01000016_gene3070 1.45e-43 163.0 COG1361@1|root,COG2911@1|root,COG1361@2|Bacteria,COG2911@2|Bacteria,4PPBJ@976|Bacteroidetes,47TYA@768503|Cytophagia 976|Bacteroidetes M Conserved repeat domain - - - - - - - - - - - - - k59_597578_1 1408473.JHXO01000001_gene1977 3.89e-51 182.0 COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - HTH_18 k59_532766_1 1221522.B723_14705 1.19e-51 184.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_989894_2 269796.Rru_A2559 2.65e-42 162.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,2JPPB@204441|Rhodospirillales 204441|Rhodospirillales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_40493_1 1279019.ARQK01000059_gene959 2.76e-09 65.1 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - GAF_2,GGDEF,HAMP,PAS_4,PocR,TPR_12,dCache_1 k59_302430_1 314278.NB231_13021 2.58e-52 186.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_760073_1 1121912.AUHD01000003_gene3137 5.02e-100 303.0 COG0493@1|root,COG0493@2|Bacteria,4NG9R@976|Bacteroidetes,1HWNF@117743|Flavobacteriia 976|Bacteroidetes E NADPH-dependent glutamate synthase beta chain and related gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_565186_1 1177179.A11A3_06903 8.44e-79 263.0 COG0823@1|root,COG0823@2|Bacteria,1R4H6@1224|Proteobacteria,1RZG6@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - - k59_727644_1 1123326.JFBL01000003_gene1919 1.53e-14 71.6 COG0546@1|root,COG0546@2|Bacteria,1RBMZ@1224|Proteobacteria,42RG3@68525|delta/epsilon subdivisions,2YP44@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hydrolase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_727644_2 929558.SMGD1_2601 1.22e-22 94.4 COG3133@1|root,COG3133@2|Bacteria,1RA1D@1224|Proteobacteria,42TU5@68525|delta/epsilon subdivisions,2YPYN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Outer membrane lipoprotein - - - ko:K06077 - - - - ko00000 - - - Rick_17kDa_Anti k59_727644_3 929558.SMGD1_1528 8.67e-05 43.9 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2YN87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Abc transporter nikZ - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_369006_2 1026882.MAMP_02906 5.11e-08 55.5 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,460I1@72273|Thiotrichales 72273|Thiotrichales D Part of the ABC transporter FtsEX involved in cellular division - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_5864_1 910964.GEAM_0452 3.67e-06 55.8 COG3948@1|root,COG3948@2|Bacteria,1MUFF@1224|Proteobacteria,1RNBJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S baseplate assembly protein gpJ - - - - - - - - - - - Baseplate_J k59_5864_2 717774.Marme_4201 7.89e-17 76.3 COG3628@1|root,COG3628@2|Bacteria,1P07N@1224|Proteobacteria 1224|Proteobacteria S GPW gp25 family protein - - - ko:K06903 - - - - ko00000 - - - GPW_gp25 k59_597604_1 1047013.AQSP01000124_gene2653 1.58e-74 247.0 COG0249@1|root,COG0249@2|Bacteria,2NNN6@2323|unclassified Bacteria 2|Bacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_727646_1 572544.Ilyop_1716 1.29e-07 52.4 COG1154@1|root,COG1154@2|Bacteria,378P4@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_727646_2 572544.Ilyop_1717 5.41e-64 199.0 COG1963@1|root,COG1963@2|Bacteria,37A36@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score 9.46 - - - ko:K09775 - - - - ko00000 - - - DUF212 k59_727646_3 1095747.HMPREF1049_1024 1.1e-34 121.0 COG1534@1|root,COG1534@2|Bacteria,37AGI@32066|Fusobacteria 32066|Fusobacteria J Psort location Cytoplasmic, score 8.96 - - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_727646_4 445973.CLOBAR_02179 1.4e-26 108.0 COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,25QRX@186804|Peptostreptococcaceae 186801|Clostridia J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_826229_1 1444711.CCJF01000003_gene35 9.52e-43 159.0 2DBB8@1|root,2Z867@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3383) Z012_10460 - - - - - - - - - - - DUF3383 k59_173039_1 1410619.SRDD_27870 4.14e-187 540.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,4026V@613|Serratia 1236|Gammaproteobacteria Q Alkyl sulfatase dimerisation BDS1 - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_695359_1 1165841.SULAR_01370 4.13e-61 191.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2YPBE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL,UPF0547 k59_695359_2 1165841.SULAR_01195 1.8e-143 416.0 COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,42T9D@68525|delta/epsilon subdivisions,2YRYA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_400981_1 717605.Theco_3263 2.06e-17 86.3 COG3409@1|root,COG3409@2|Bacteria,1UWKK@1239|Firmicutes,4HBYN@91061|Bacilli,26VEM@186822|Paenibacillaceae 91061|Bacilli M Copper amine oxidase N-terminal domain - - - - - - - - - - - - Cu_amine_oxidN1 k59_336874_1 387093.SUN_1520 5.95e-138 402.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,42MN7@68525|delta/epsilon subdivisions,2YN3I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_1022381_1 1168034.FH5T_02115 1.33e-202 572.0 COG3534@1|root,COG3534@2|Bacteria,4NECK@976|Bacteroidetes,2FNNB@200643|Bacteroidia 976|Bacteroidetes G Alpha-L-arabinofuranosidase domain protein abf2 - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C k59_141334_2 2340.JV46_28020 1.34e-55 192.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1J6RI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Insulinase (Peptidase family M16) - - 2.7.7.6 ko:K00960,ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_206026_1 1121115.AXVN01000026_gene1026 3.11e-23 101.0 COG1131@1|root,COG1131@2|Bacteria,1TPBQ@1239|Firmicutes,247M8@186801|Clostridia,3XZCK@572511|Blautia 186801|Clostridia V ATPases associated with a variety of cellular activities bcrA - - ko:K19309 ko02010,map02010 M00747 - - ko00000,ko00001,ko00002,ko02000 3.A.1.131.1 - - ABC_tran k59_631809_2 472759.Nhal_0298 3.87e-42 143.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,1S2YD@1236|Gammaproteobacteria,1WY4X@135613|Chromatiales 135613|Chromatiales T low molecular weight - - 1.20.4.1 ko:K03741,ko:K03892 - - - - ko00000,ko01000,ko03000 - - - HTH_5,LMWPc k59_109032_1 1265503.KB905160_gene2872 2.17e-65 215.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_239175_1 1408473.JHXO01000006_gene1255 6.41e-151 464.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,4NFKH@976|Bacteroidetes,2FNH9@200643|Bacteroidia 976|Bacteroidetes E Glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_957945_1 1168034.FH5T_02780 1.1e-24 105.0 COG0457@1|root,COG0457@2|Bacteria,4NG1I@976|Bacteroidetes,2FQPG@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat protein - - - - - - - - - - - - TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_957945_2 1349822.NSB1T_04630 1.39e-25 102.0 COG2035@1|root,COG2035@2|Bacteria,4NFKI@976|Bacteroidetes,2FPD1@200643|Bacteroidia,22WH6@171551|Porphyromonadaceae 976|Bacteroidetes S Domain of unknown function (DUF368) - - - ko:K08974 - - - - ko00000 - - - DUF368 k59_434529_1 396588.Tgr7_0459 1.92e-57 189.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - - - - - - - - - - T2SSE k59_434529_2 378806.STAUR_7821 6.57e-05 45.8 COG0515@1|root,COG0515@2|Bacteria,1QTAS@1224|Proteobacteria,438K2@68525|delta/epsilon subdivisions,2X9FQ@28221|Deltaproteobacteria,2YX5C@29|Myxococcales 28221|Deltaproteobacteria KLT PEGA domain - - - - - - - - - - - - PEGA,Pkinase k59_892765_1 1537917.JU82_04475 3.71e-85 258.0 COG0171@1|root,COG0171@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2YNG2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase k59_991448_1 570967.JMLV01000001_gene2800 3.29e-45 154.0 COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,2U2U3@28211|Alphaproteobacteria,2JS2F@204441|Rhodospirillales 204441|Rhodospirillales M glycosyl transferase family 8 - - - - - - - - - - - - - k59_991448_2 314278.NB231_04125 1.15e-28 110.0 COG3751@1|root,COG3751@2|Bacteria,1RAJ8@1224|Proteobacteria,1S3II@1236|Gammaproteobacteria 1236|Gammaproteobacteria O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - - k59_109036_1 1380600.AUYN01000009_gene1443 2.59e-150 456.0 COG3250@1|root,COG3250@2|Bacteria,4NEP8@976|Bacteroidetes,1HZ78@117743|Flavobacteriia 976|Bacteroidetes G Glycosyl hydrolases family 2, sugar binding domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_664888_1 870187.Thini_2525 9.31e-08 58.5 COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1T248@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K20975 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_7,PAS_8,Response_reg,RsbRD_N k59_434533_1 1499967.BAYZ01000181_gene4505 3.95e-38 147.0 COG4585@1|root,COG5002@1|root,COG4585@2|Bacteria,COG5002@2|Bacteria,2NPMD@2323|unclassified Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07675 ko02020,map02020 M00473 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GGDEF,HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg k59_370419_1 498761.HM1_0841 3.94e-62 213.0 COG3290@1|root,COG3829@1|root,COG3290@2|Bacteria,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia 186801|Clostridia KT Sigma-54 interaction domain - - - - - - - - - - - - PAS,PTS-HPr,Sigma54_activat k59_1023285_1 1168034.FH5T_21755 2.15e-77 233.0 COG0610@1|root,COG0610@2|Bacteria,4PKFE@976|Bacteroidetes,2FPFZ@200643|Bacteroidia 976|Bacteroidetes V type I restriction enzyme - - - - - - - - - - - - HSDR_N_2 k59_1023285_2 1168034.FH5T_21750 6.3e-82 246.0 COG1670@1|root,COG1670@2|Bacteria,4NQ8K@976|Bacteroidetes,2FMII@200643|Bacteroidia 976|Bacteroidetes J Acetyltransferase, gnat family speG - 2.3.1.57 ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_3 k59_827526_1 1116472.MGMO_159c00020 1.31e-101 304.0 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the class I fructose-bisphosphate aldolase family alf1 - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_370420_1 367737.Abu_1734 1.55e-39 142.0 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,42UAQ@68525|delta/epsilon subdivisions,2YRBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM Cytochrome c, class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - - k59_370420_2 944546.ABED_1576 7.19e-50 171.0 COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1RE9S@1224|Proteobacteria,43ANP@68525|delta/epsilon subdivisions,2YT2J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_926328_1 875328.JDM601_1297 4.4e-13 64.7 COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,23ANR@1762|Mycobacteriaceae 201174|Actinobacteria J 50S ribosomal protein L31 rpmE GO:0008150,GO:0040007 - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_926328_2 1121413.JMKT01000008_gene1650 4.9e-65 210.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2M8U2@213115|Desulfovibrionales 28221|Deltaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_501579_1 595494.Tola_1794 6.78e-21 92.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RMGZ@1236|Gammaproteobacteria,1Y6EK@135624|Aeromonadales 135624|Aeromonadales CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_991472_1 1121035.AUCH01000012_gene2923 2.06e-57 183.0 COG4314@1|root,COG4314@2|Bacteria,1N43A@1224|Proteobacteria,2VQI4@28216|Betaproteobacteria,2KWIY@206389|Rhodocyclales 206389|Rhodocyclales C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - NosL k59_566592_1 1286632.P278_33380 4.48e-94 287.0 COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,1HWQS@117743|Flavobacteriia 976|Bacteroidetes H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_957968_1 1172190.M947_07850 9.03e-65 219.0 COG1287@1|root,COG1287@2|Bacteria,1R481@1224|Proteobacteria,42MNZ@68525|delta/epsilon subdivisions,2YMU3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Oligosaccharyl transferase, STT3 subunit pglB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0034645,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046872,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.99.18,2.4.99.19 ko:K07151,ko:K17251 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_76185_1 1168034.FH5T_05075 2.53e-68 220.0 COG0719@1|root,COG0719@2|Bacteria,4NFPG@976|Bacteroidetes,2FNCN@200643|Bacteroidia 976|Bacteroidetes O FeS assembly protein SufD sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_76185_2 1168034.FH5T_05070 2.03e-57 184.0 COG0396@1|root,COG0396@2|Bacteria,4NEMY@976|Bacteroidetes,2FMCD@200643|Bacteroidia 976|Bacteroidetes O FeS assembly ATPase SufC sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_991473_1 1379270.AUXF01000001_gene2161 2.32e-64 221.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_239205_1 1005048.CFU_1112 1.3e-53 184.0 COG0438@1|root,COG0438@2|Bacteria,1R7N8@1224|Proteobacteria 1224|Proteobacteria M Glycosyltransferase - - - - - - - - - - - - Glyco_trans_1_4 k59_534349_1 1168034.FH5T_03175 1.08e-24 95.9 2ET9N@1|root,33KTN@2|Bacteria,4NZKP@976|Bacteroidetes,2FZMH@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_534349_2 1168034.FH5T_03165 1.05e-66 209.0 COG0483@1|root,COG0483@2|Bacteria,4NI6D@976|Bacteroidetes,2FNAK@200643|Bacteroidia 976|Bacteroidetes G Psort location Cytoplasmic, score suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_827539_1 90813.JQMT01000001_gene932 7.35e-22 88.2 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,46105@72273|Thiotrichales 72273|Thiotrichales I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_827539_2 493475.GARC_2914 1.3e-17 84.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,4642M@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - ic_1306.c0216 Hexapep,Hexapep_2,LpxD k59_338433_1 768671.ThimaDRAFT_2533 1.92e-23 98.6 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1WW0A@135613|Chromatiales 135613|Chromatiales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_434552_1 1121405.dsmv_0463 8.02e-43 153.0 COG3156@1|root,COG3156@2|Bacteria,1PZ6I@1224|Proteobacteria,42Q46@68525|delta/epsilon subdivisions,2WM8B@28221|Deltaproteobacteria,2MI8C@213118|Desulfobacterales 28221|Deltaproteobacteria U General secretion pathway protein K - - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_501594_1 1049564.TevJSym_at00690 4.19e-93 290.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1J5HU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the biosynthesis of agmatine from arginine speA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283 Orn_Arg_deC_N k59_827540_1 1168034.FH5T_05415 3.12e-232 645.0 COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,2FM43@200643|Bacteroidia 976|Bacteroidetes E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_827540_2 999419.HMPREF1077_02486 4.93e-19 85.9 COG0459@1|root,COG0459@2|Bacteria,4NDZM@976|Bacteroidetes,2FMH4@200643|Bacteroidia,22WR5@171551|Porphyromonadaceae 976|Bacteroidetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_6643_1 1082933.MEA186_22906 8.25e-85 260.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,43IBF@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_957984_1 1249480.B649_01665 1.2e-22 94.7 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,42MQQ@68525|delta/epsilon subdivisions,2YNAG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L dna polymerase iii dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_957984_2 1537917.JU82_04010 6.47e-183 513.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,42NC2@68525|delta/epsilon subdivisions,2YMTQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_957984_3 1537917.JU82_04005 1.05e-67 216.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2YMR3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_859759_1 521011.Mpal_0846 9.63e-57 186.0 COG3640@1|root,arCOG00587@2157|Archaea,2XW7J@28890|Euryarchaeota,2N9VV@224756|Methanomicrobia 224756|Methanomicrobia D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K07321 - - - - ko00000 - - - CbiA k59_599176_1 387093.SUN_1781 2.06e-91 274.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2YN5P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_631864_1 1121405.dsmv_2856 3.14e-209 602.0 COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_434568_1 1120951.AUBG01000016_gene3594 1.73e-96 293.0 COG4948@1|root,COG4948@2|Bacteria,4NEBX@976|Bacteroidetes,1HY3V@117743|Flavobacteriia 976|Bacteroidetes M mandelate racemase menC - - - - - - - - - - - MR_MLE_C k59_501609_1 1120792.JAFV01000001_gene1338 2.64e-25 107.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria,36ZJB@31993|Methylocystaceae 28211|Alphaproteobacteria G Glucose-6-phosphate dehydrogenase, NAD binding domain zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_501609_2 1165841.SULAR_03502 7.56e-09 60.1 COG0526@1|root,COG0526@2|Bacteria,1R0XY@1224|Proteobacteria,43D37@68525|delta/epsilon subdivisions,2YTFX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredoxin_7 k59_501609_3 572480.Arnit_2358 8.92e-27 101.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2YPGD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_402403_1 1168034.FH5T_07865 6.66e-74 223.0 COG1959@1|root,COG1959@2|Bacteria,4NQGU@976|Bacteroidetes,2FYF3@200643|Bacteroidia 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_402403_3 1168034.FH5T_07875 3.26e-72 228.0 COG0635@1|root,COG0635@2|Bacteria,4NFEE@976|Bacteroidetes,2FPFC@200643|Bacteroidia 976|Bacteroidetes H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM k59_761591_1 1168034.FH5T_01495 7.37e-66 212.0 COG1595@1|root,COG2202@1|root,COG1595@2|Bacteria,COG2202@2|Bacteria 2|Bacteria T Pas domain - - - ko:K03088 - - - - ko00000,ko03021 - - - DUF4157,HATPase_c,PAS,PAS_3,PAS_9,SatD,Sigma70_r2 k59_534370_3 749222.Nitsa_0437 1.15e-39 139.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2YN5P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_206972_1 765911.Thivi_0756 1.45e-15 75.5 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXFS@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_206972_2 572477.Alvin_1542 4.01e-56 191.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1WXJP@135613|Chromatiales 135613|Chromatiales M PFAM glycosyl transferase family 39 - - - - - - - - - - - - PMT_2 k59_926372_1 690850.Desaf_1307 3.49e-21 94.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,42QX9@68525|delta/epsilon subdivisions,2WKS8@28221|Deltaproteobacteria,2M9ZD@213115|Desulfovibrionales 28221|Deltaproteobacteria EGP PFAM Major Facilitator Superfamily - - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1 k59_761595_1 517417.Cpar_1321 1.17e-47 154.0 2C54Q@1|root,3498C@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_434578_1 572544.Ilyop_1901 1.95e-35 136.0 COG1197@1|root,COG1197@2|Bacteria,378H0@32066|Fusobacteria 32066|Fusobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_792857_1 265072.Mfla_0139 8.49e-21 93.2 COG3117@1|root,COG3117@2|Bacteria,1R5UK@1224|Proteobacteria,2VU37@28216|Betaproteobacteria,2KMR4@206350|Nitrosomonadales 206350|Nitrosomonadales S Lipopolysaccharide-assembly, LptC-related - - - ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC k59_792857_2 1166948.JPZL01000001_gene2454 3.05e-06 48.5 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1XJXX@135619|Oceanospirillales 135619|Oceanospirillales S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase,Hydrolase_3 k59_76227_1 1121015.N789_08755 1.75e-94 295.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1X2YR@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_206980_1 153948.NAL212_0013 3.65e-77 236.0 COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VSUV@28216|Betaproteobacteria 28216|Betaproteobacteria L ISXO2-like transposase domain - - - ko:K07488 - - - - ko00000 - - - DDE_Tnp_IS1595 k59_109100_1 565045.NOR51B_317 1.13e-73 240.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_664958_1 883114.HMPREF9709_00117 1.14e-11 64.7 COG0745@1|root,COG0745@2|Bacteria,1TQY9@1239|Firmicutes,24D6A@186801|Clostridia,22H27@1570339|Peptoniphilaceae 186801|Clostridia K Response regulator receiver domain protein phoB - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_926379_1 1122929.KB908215_gene438 2.88e-51 174.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E O-acetylhomoserine metY GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 ko:K01738,ko:K01740 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R01287,R03601,R04859 RC00020,RC02814,RC02821,RC02848 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_566644_1 933262.AXAM01000019_gene1105 8.76e-56 182.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WN14@28221|Deltaproteobacteria,2MJKK@213118|Desulfobacterales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily ycbL - - - - - - - - - - - Lactamase_B k59_76234_1 387093.SUN_0591 1.48e-147 427.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2YMRT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_270982_1 87626.PTD2_14184 3.52e-21 93.6 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q12B@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_270982_2 1127673.GLIP_1600 3.44e-12 68.2 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria,469SX@72275|Alteromonadaceae 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_338489_1 313594.PI23P_04842 9.86e-224 649.0 COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,1HXWA@117743|Flavobacteriia 976|Bacteroidetes P receptor - - - - - - - - - - - - CarboxypepD_reg,TonB_dep_Rec k59_434600_1 644801.Psest_1345 1.68e-117 352.0 COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,1RPTW@1236|Gammaproteobacteria,1YZSV@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S FAD-dependent IV02_08645 - - ko:K07137 - - - - ko00000 - - - Amino_oxidase k59_303685_1 1349767.GJA_1694 3.18e-43 167.0 COG1450@1|root,COG1450@2|Bacteria,1MV6H@1224|Proteobacteria,2VM88@28216|Betaproteobacteria,475UG@75682|Oxalobacteraceae 28216|Betaproteobacteria U PFAM Bacterial type II III secretion system short domain, Bacterial type II and III secretion system protein bscC - - ko:K03219 ko03070,map03070 M00332,M00542 - - ko00000,ko00001,ko00002,ko02044 3.A.6.1,3.A.6.3 - - Secretin,Secretin_N k59_761620_1 926561.KB900618_gene314 3.63e-97 300.0 COG4773@1|root,COG4773@2|Bacteria 2|Bacteria P Receptor - - - - - - - - - - - - Plug k59_761620_2 926561.KB900618_gene315 3.4e-99 297.0 COG2834@1|root,COG2834@2|Bacteria,1V6F3@1239|Firmicutes,24MGP@186801|Clostridia,3WAQP@53433|Halanaerobiales 186801|Clostridia M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_1023361_1 765910.MARPU_04725 2.54e-83 270.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WWIV@135613|Chromatiales 135613|Chromatiales G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_370490_1 552811.Dehly_1676 1.85e-39 133.0 COG3311@1|root,COG3311@2|Bacteria,2G7I6@200795|Chloroflexi 200795|Chloroflexi L TIGRFAM DNA binding domain - - - - - - - - - - - - HTH_17 k59_370490_2 552811.Dehly_1677 7.84e-87 283.0 COG0507@1|root,COG0782@1|root,COG1112@1|root,COG0507@2|Bacteria,COG0782@2|Bacteria,COG1112@2|Bacteria 2|Bacteria L Superfamily I DNA and RNA helicases and helicase subunits - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,DUF559,GreA_GreB k59_599221_1 1122947.FR7_1808 5.62e-88 281.0 COG0331@1|root,COG2070@1|root,COG0331@2|Bacteria,COG2070@2|Bacteria,1UG0E@1239|Firmicutes,4H74S@909932|Negativicutes 909932|Negativicutes I Acyl transferase domain - - - - - - - - - - - - Acyl_transf_1 k59_403020_1 713586.KB900536_gene348 2.32e-87 273.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_339147_1 387093.SUN_1747 1.25e-83 252.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2YMCQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_109636_1 572544.Ilyop_1378 1.66e-81 254.0 COG2861@1|root,COG2861@2|Bacteria 2|Bacteria M carbohydrate metabolic process yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_142989_1 1121324.CLIT_4c00230 1.75e-15 81.3 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,25QDG@186804|Peptostreptococcaceae 186801|Clostridia JKL Belongs to the DEAD box helicase family cshA - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_535075_1 1131812.JQMS01000001_gene1655 1.8e-18 89.4 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1HXUN@117743|Flavobacteriia,2P0MK@237|Flavobacterium 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_149282_1 765912.Thimo_2584 7.18e-114 353.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_48236_1 472759.Nhal_1988 1.07e-125 375.0 COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,1RN0A@1236|Gammaproteobacteria,1WZMA@135613|Chromatiales 135613|Chromatiales L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_409410_1 243233.MCA0419 1.22e-10 59.3 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria,1XF78@135618|Methylococcales 135618|Methylococcales O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_409410_2 857087.Metme_2348 8.31e-08 50.4 COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,1XFW4@135618|Methylococcales 135618|Methylococcales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes - - - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - - CcmD k59_409410_3 1116472.MGMO_41c00600 8.19e-83 252.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1XDXU@135618|Methylococcales 135618|Methylococcales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_866694_1 1168034.FH5T_12490 4.02e-32 118.0 COG0546@1|root,COG0546@2|Bacteria,4PM7Q@976|Bacteroidetes 976|Bacteroidetes S haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E - - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_798386_1 1168034.FH5T_04295 1.93e-65 226.0 COG3209@1|root,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,2FUDR@200643|Bacteroidia 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,SprB k59_606570_1 385682.AFSL01000012_gene2837 9.96e-99 315.0 2DB7A@1|root,2Z7KK@2|Bacteria,4NGC2@976|Bacteroidetes,2FMN6@200643|Bacteroidia,3XJMU@558415|Marinilabiliaceae 976|Bacteroidetes G Glycosyl hydrolase family 115 - - - - - - - - - - - - Glyco_hydro_115 k59_769080_1 1026882.MAMP_01036 5.99e-85 273.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,45ZWJ@72273|Thiotrichales 72273|Thiotrichales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_703949_1 640081.Dsui_3448 5.68e-74 230.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,2KW1K@206389|Rhodocyclales 206389|Rhodocyclales T Transcriptional regulatory protein, C terminal - - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_149299_1 1121904.ARBP01000095_gene1598 3.23e-97 288.0 COG1484@1|root,COG1484@2|Bacteria,4NFE0@976|Bacteroidetes,47P7E@768503|Cytophagia 976|Bacteroidetes L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_606580_1 1168034.FH5T_04175 1.03e-197 583.0 COG0085@1|root,COG0085@2|Bacteria,4NF8D@976|Bacteroidetes,2FMDI@200643|Bacteroidia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_769091_1 713586.KB900536_gene2226 8.65e-101 319.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_441574_2 313595.P700755_001169 4.44e-10 59.7 COG4319@1|root,COG4319@2|Bacteria,4NYPP@976|Bacteroidetes 976|Bacteroidetes S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 k59_12144_1 118005.AWNK01000003_gene2230 0.0 1066.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria 2|Bacteria G chondroitin AC lyase activity ndvB - 2.4.1.12,3.2.1.58 ko:K00694,ko:K01210,ko:K03292 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R00308,R02889,R03115 RC00005,RC00467 ko00000,ko00001,ko01000,ko01003,ko02000 2.A.2,4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,MFS_2 k59_12144_2 1049564.TevJSym_aw00380 8.08e-26 100.0 2ER47@1|root,33IPS@2|Bacteria,1NHAY@1224|Proteobacteria 1224|Proteobacteria S chemotaxis protein - - - - - - - - - - - - DUF2802 k59_12144_4 1049564.TevJSym_aw00390 1.2e-75 229.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,1SYDF@1236|Gammaproteobacteria,1J63R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0835 Chemotaxis signal transduction protein cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_12144_5 857087.Metme_4056 1.22e-26 110.0 COG0835@1|root,COG0835@2|Bacteria,1PBY5@1224|Proteobacteria,1SWRP@1236|Gammaproteobacteria,1XGSI@135618|Methylococcales 135618|Methylococcales NT chemotaxis - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - - k59_12144_6 1049564.TevJSym_aw00410 7.85e-111 327.0 COG1192@1|root,COG1192@2|Bacteria,1MWSE@1224|Proteobacteria,1RQ3X@1236|Gammaproteobacteria,1J5TS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1192 ATPases involved in chromosome partitioning XCC1889 - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_12144_7 1049564.TevJSym_aw00420 1.92e-78 247.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,1S294@1236|Gammaproteobacteria,1J60E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_12144_8 1049564.TevJSym_aw00430 2.97e-125 362.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,1RNWB@1236|Gammaproteobacteria,1J5BM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N COG1291 Flagellar motor component motC - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_12144_9 519989.ECTPHS_04618 1.01e-108 330.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,1WWSE@135613|Chromatiales 135613|Chromatiales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_12144_10 857087.Metme_4060 9.45e-235 679.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XDPM@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, phosphotransfer (Hpt) region - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_12144_11 1049564.TevJSym_aw00460 3.4e-82 253.0 COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,1RNG2@1236|Gammaproteobacteria,1J6E7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) cheZ GO:0001539,GO:0003674,GO:0003824,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032991,GO:0036211,GO:0040011,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071704,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0097588,GO:0098561,GO:0140096,GO:1901564 - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ k59_12144_12 157783.LK03_12660 3.35e-68 208.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,1S47I@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT Chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_12144_13 1049564.TevJSym_aw00480 2.58e-122 355.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1J5PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_12144_14 1049564.TevJSym_aw00490 3.04e-154 439.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RMZ2@1236|Gammaproteobacteria,1J4GX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Belongs to the ParA family fleN - - ko:K04562 - - - - ko00000,ko02035 - - - ParA k59_12144_15 1049564.TevJSym_aw00500 1.44e-142 421.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,1RMUU@1236|Gammaproteobacteria,1J5U1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N COG1419 Flagellar GTP-binding protein flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_48771_1 1168034.FH5T_05125 3.33e-103 308.0 COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,2FNG4@200643|Bacteroidia 976|Bacteroidetes K Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Acetyltransf_1 k59_799020_1 2340.JV46_02830 4.09e-83 269.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1J52I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_214980_2 748247.AZKH_1001 1.69e-13 69.3 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,2KWVI@206389|Rhodocyclales 206389|Rhodocyclales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_214980_3 1346791.M529_02620 3.58e-55 179.0 COG0500@1|root,COG0500@2|Bacteria,1RDRV@1224|Proteobacteria,2U70C@28211|Alphaproteobacteria,2KBHY@204457|Sphingomonadales 204457|Sphingomonadales Q Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25 k59_475183_1 1121912.AUHD01000003_gene2983 1.14e-20 91.7 COG1629@1|root,COG4771@2|Bacteria,4NET0@976|Bacteroidetes,1HY46@117743|Flavobacteriia 976|Bacteroidetes P Outer membrane receptor for ferrienterochelin and colicins hmuR - - ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_475183_2 1121912.AUHD01000003_gene2982 1.36e-32 119.0 2DBWZ@1|root,2ZBKJ@2|Bacteria,4NMS8@976|Bacteroidetes,1I1GJ@117743|Flavobacteriia 976|Bacteroidetes S HmuY protein - - - - - - - - - - - - HmuY k59_509776_1 1304275.C41B8_15245 2.55e-50 174.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - iZ_1308.Z4900 Pyr_redox_2,Pyr_redox_dim k59_704440_3 240292.Ava_D0020 9.72e-18 79.3 2CPKU@1|root,32SJD@2|Bacteria,1G8WS@1117|Cyanobacteria,1HSH3@1161|Nostocales 1117|Cyanobacteria L 3' exoribonuclease, RNase T-like - - - - - - - - - - - - DUF5051 k59_639621_1 1168034.FH5T_12805 1.23e-86 275.0 COG0480@1|root,COG0480@2|Bacteria,4NE9X@976|Bacteroidetes,2FM1M@200643|Bacteroidia 976|Bacteroidetes J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_835071_1 290398.Csal_2377 2.86e-95 282.0 2DCY0@1|root,2ZFRZ@2|Bacteria,1P74I@1224|Proteobacteria,1STKE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_574056_1 472759.Nhal_3011 5.06e-36 141.0 COG0515@1|root,COG1262@1|root,COG3409@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG3409@2|Bacteria,1NQ5K@1224|Proteobacteria,1S2PN@1236|Gammaproteobacteria,1WYNY@135613|Chromatiales 135613|Chromatiales KLT PFAM Sulphatase-modifying factor - - - - - - - - - - - - FGE-sulfatase,PEGA,PG_binding_1,Pkinase k59_639622_1 314278.NB231_08132 3.99e-33 127.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_639622_2 553217.ENHAE0001_1351 4.08e-17 75.5 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,3NNIS@468|Moraxellaceae 1236|Gammaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0046983,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_965860_1 1122604.JONR01000013_gene3213 1.01e-57 191.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,1RP7Q@1236|Gammaproteobacteria,1X337@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulator - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_965862_1 1318628.MARLIPOL_05525 4.24e-60 192.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,466MM@72275|Alteromonadaceae 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_246626_1 95619.PM1_0213035 2.34e-59 204.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.41,3.2.1.68 ko:K01200,ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_475190_1 1163617.SCD_n02189 4.42e-26 107.0 COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,2VPWB@28216|Betaproteobacteria 28216|Betaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2 k59_607089_1 501479.ACNW01000062_gene2740 3.05e-79 254.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_277813_1 1168034.FH5T_18895 5.81e-27 107.0 COG0457@1|root,COG0457@2|Bacteria,4NWTK@976|Bacteroidetes 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19,TPR_8 k59_277813_2 694427.Palpr_2594 1.77e-14 73.2 COG0671@1|root,COG0671@2|Bacteria,4NV5Q@976|Bacteroidetes,2FYR6@200643|Bacteroidia 976|Bacteroidetes I Acid phosphatase homologues - - - - - - - - - - - - PAP2 k59_12738_1 1249627.D779_2002 3.18e-41 144.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,1S7F5@1236|Gammaproteobacteria,1WZ5W@135613|Chromatiales 135613|Chromatiales NT PFAM CheW-like - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_999197_1 999141.GME_04387 5.71e-63 207.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1XIU0@135619|Oceanospirillales 135619|Oceanospirillales C FAD linked oxidase - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_1030562_1 207954.MED92_10219 3.4e-29 121.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria,1XI74@135619|Oceanospirillales 135619|Oceanospirillales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_7 k59_182459_1 572544.Ilyop_1354 2.08e-49 177.0 COG2217@1|root,COG2217@2|Bacteria,378U0@32066|Fusobacteria 32066|Fusobacteria P Psort location CytoplasmicMembrane, score 10.00 cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase k59_12758_1 572544.Ilyop_0630 5.18e-52 179.0 COG5002@1|root,COG5002@2|Bacteria,3788W@32066|Fusobacteria 32066|Fusobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_835103_1 1449126.JQKL01000008_gene293 1.25e-75 243.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,267RV@186813|unclassified Clostridiales 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_377631_2 1123393.KB891316_gene1266 1.6e-30 117.0 COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,2WDTN@28216|Betaproteobacteria,1KSHJ@119069|Hydrogenophilales 119069|Hydrogenophilales O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_933768_1 1397527.Q670_14590 5.27e-29 114.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,1XJFN@135619|Oceanospirillales 135619|Oceanospirillales O Thiol disulfide interchange protein dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA k59_735991_1 1123253.AUBD01000002_gene1296 2.47e-14 74.3 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1X3RB@135614|Xanthomonadales 135614|Xanthomonadales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_735991_2 998088.B565_3870 6.68e-52 171.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1Y4EQ@135624|Aeromonadales 135624|Aeromonadales S Bacterial transferase hexapeptide (six repeats) - - - - - - - - - - - - Hexapep k59_933769_1 572477.Alvin_2212 1.61e-140 411.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_574075_1 243365.CV_1081 1.8e-05 52.4 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2W05Y@28216|Betaproteobacteria,2KTRK@206351|Neisseriales 28216|Betaproteobacteria NT Pfam:Cache_1 - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - HAMP,MCPsignal,dCache_1 k59_277847_1 96561.Dole_2367 9.89e-34 124.0 COG1309@1|root,COG1309@2|Bacteria,1MV2V@1224|Proteobacteria,42NW6@68525|delta/epsilon subdivisions,2WPIG@28221|Deltaproteobacteria,2MI81@213118|Desulfobacterales 28221|Deltaproteobacteria K Tetracycline transcriptional regulator YsiA domain protein - - - ko:K13770 - - - - ko00000,ko03000 - - - TetR_C_4,TetR_N k59_574081_1 616991.JPOO01000001_gene4008 2.62e-63 214.0 COG3525@1|root,COG3525@2|Bacteria,4NEQN@976|Bacteroidetes,1HWKP@117743|Flavobacteriia,23IF7@178469|Arenibacter 976|Bacteroidetes G Domain of unknown function (DUF4838) - - - - - - - - - - - - DUF4838,F5_F8_type_C,Glyco_hydro_67N k59_704493_1 1121403.AUCV01000001_gene768 4.6e-57 196.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2WK8Q@28221|Deltaproteobacteria,2MIXM@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the 5'-nucleotidase family - - 3.1.3.5,3.6.1.45 ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_965901_1 1537917.JU82_11630 3.38e-92 292.0 COG1538@1|root,COG2885@1|root,COG1538@2|Bacteria,COG2885@2|Bacteria,1MYX2@1224|Proteobacteria,42Q7M@68525|delta/epsilon subdivisions,2YNPH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU outer membrane protein, TolC family - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP k59_246681_1 265729.GS18_0212975 2.86e-78 244.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,4HAIV@91061|Bacilli,1ZDD3@1386|Bacillus 91061|Bacilli O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11,1.8.4.12 ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_246681_2 476272.RUMHYD_01790 4.92e-149 436.0 COG0498@1|root,COG0498@2|Bacteria,1TPR0@1239|Firmicutes,248YY@186801|Clostridia,3XZ3J@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS16355 PALP,Thr_synth_N k59_867309_1 880070.Cycma_4833 3.09e-44 164.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,4NDXS@976|Bacteroidetes,47KJT@768503|Cytophagia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_769711_1 1121405.dsmv_2242 8.71e-95 288.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria,2MI6J@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Nitrate_red_gam k59_933785_1 82995.CR62_07015 2.44e-09 60.8 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,4022G@613|Serratia 1236|Gammaproteobacteria I Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396 LpxK k59_933785_2 85643.Tmz1t_3214 2.04e-22 87.8 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,2KXCI@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p k59_672790_1 869213.JCM21142_104068 1.81e-14 71.2 COG1066@1|root,COG1066@2|Bacteria 2|Bacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function - - - ko:K06919 - - - - ko00000 - - - AAA_16,AAA_25,DnaB k59_672790_2 869213.JCM21142_104069 5.63e-112 324.0 COG1066@1|root,COG1066@2|Bacteria 2|Bacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_182490_2 572477.Alvin_0952 3.01e-45 154.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1WWA0@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_215035_1 472759.Nhal_1758 1.68e-55 191.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1X0G4@135613|Chromatiales 135613|Chromatiales I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_799108_1 870187.Thini_1248 2.07e-98 310.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,4603Y@72273|Thiotrichales 72273|Thiotrichales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family napA - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_48836_1 572544.Ilyop_1428 6.24e-133 392.0 COG1323@1|root,COG1323@2|Bacteria,378XC@32066|Fusobacteria 32066|Fusobacteria S Belongs to the UPF0348 family - - - - - - - - - - - - HIGH_NTase1 k59_149904_1 1268237.G114_01354 5.1e-21 97.1 COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,1T1X7@1236|Gammaproteobacteria 1236|Gammaproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1030603_1 1307761.L21SP2_1293 1.96e-18 82.4 COG0225@1|root,COG0225@2|Bacteria,2J5BJ@203691|Spirochaetes 203691|Spirochaetes O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_1030603_2 435591.BDI_1723 2.84e-12 68.2 COG1893@1|root,COG1893@2|Bacteria,4NMFF@976|Bacteroidetes,2FNZU@200643|Bacteroidia,22XU7@171551|Porphyromonadaceae 976|Bacteroidetes H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_644683_1 1469557.JSWF01000014_gene2478 1.79e-37 136.0 COG0621@1|root,COG0621@2|Bacteria,4NEJK@976|Bacteroidetes,1HXRF@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_872357_1 83406.HDN1F_09610 2.02e-46 169.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_644687_1 981383.AEWH01000057_gene2415 2.84e-38 151.0 COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HV19@91061|Bacilli 91061|Bacilli Q polyketide synthase - - - - - - - - - - - - AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NAD_binding_4,PP-binding,PS-DH,ketoacyl-synt k59_578847_1 519989.ECTPHS_13183 3.85e-168 478.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1WWB2@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_578847_2 187272.Mlg_0484 1.15e-63 197.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1WY9H@135613|Chromatiales 135613|Chromatiales J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_578847_3 670487.Ocepr_0136 2.21e-33 129.0 COG1912@1|root,COG1912@2|Bacteria,1WIIQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_578847_6 765912.Thimo_1939 1.9e-159 461.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,1RZ4V@1236|Gammaproteobacteria,1WW06@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_578847_7 1304888.ATWF01000001_gene2520 9.4e-200 570.0 COG2199@1|root,COG3706@2|Bacteria,2GG7S@200930|Deferribacteres 200930|Deferribacteres T Cache domain - - - - - - - - - - - - GGDEF,dCache_1 k59_578847_8 768671.ThimaDRAFT_1693 3.31e-120 354.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,1WXRH@135613|Chromatiales 135613|Chromatiales S PFAM Bile acid sodium symporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_578847_9 519989.ECTPHS_03076 0.0 1446.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_578847_10 1392490.JHZX01000001_gene2115 1.51e-13 65.9 2ENDF@1|root,33G0X@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PLDc_N k59_578847_11 1408254.T458_20890 4.07e-48 164.0 COG0346@1|root,COG0494@1|root,COG0346@2|Bacteria,COG0494@2|Bacteria,1V7D7@1239|Firmicutes,4HIGP@91061|Bacilli,26YJ6@186822|Paenibacillaceae 91061|Bacilli E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase,NUDIX k59_578847_12 870187.Thini_1077 0.0 990.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,4607W@72273|Thiotrichales 72273|Thiotrichales M sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_578847_13 1121918.ARWE01000001_gene1628 6.75e-102 306.0 COG0561@1|root,COG0561@2|Bacteria,1QFFG@1224|Proteobacteria,42R6U@68525|delta/epsilon subdivisions,2WN0Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria S HAD-superfamily hydrolase, subfamily IIB - - - - - - - - - - - - S6PP k59_578847_14 697282.Mettu_3116 3.43e-88 273.0 COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1XE9X@135618|Methylococcales 135618|Methylococcales G PFAM Carbohydrate purine kinase - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_578847_15 870187.Thini_1074 0.0 1019.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,45ZPC@72273|Thiotrichales 72273|Thiotrichales G PFAM alpha amylase, catalytic - - 2.4.1.4 ko:K05341 ko00500,map00500 - R01823 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_578847_16 2340.JV46_16660 1.35e-175 506.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1J4FQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP major facilitator superfamily yajR GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - MFS_1,Sugar_tr k59_578847_17 550540.Fbal_3483 1.3e-61 196.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_578847_19 1298593.TOL_2459 3.74e-49 171.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1XKAP@135619|Oceanospirillales 135619|Oceanospirillales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_578847_21 159087.Daro_1151 1.12e-234 668.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_578847_22 301.JNHE01000014_gene2988 7.43e-35 123.0 COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,1S8Z3@1236|Gammaproteobacteria,1YK7M@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Protein of unknown function (DUF559) - - - - - - - - - - - - DUF559 k59_382550_1 1123257.AUFV01000003_gene1059 2.1e-39 136.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1X6GJ@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_382550_2 105559.Nwat_0349 1.07e-26 109.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales 135613|Chromatiales U type IV pilus secretin PilQ - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_612054_1 304371.MCP_2259 3.87e-60 199.0 COG0477@1|root,arCOG00130@2157|Archaea,2XWXX@28890|Euryarchaeota,2N9J6@224756|Methanomicrobia 224756|Methanomicrobia G TIGRFAM drug resistance transporter, Bcr CflA subfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_774718_1 1121033.AUCF01000001_gene2215 6.95e-59 192.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,2JP9M@204441|Rhodospirillales 204441|Rhodospirillales K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_187504_1 631362.Thi970DRAFT_03306 1.22e-138 415.0 COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales 135613|Chromatiales M sucrose synthase - - 2.4.1.13 ko:K00695 ko00500,ko01100,map00500,map01100 - R00806 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000,ko01003 - GT4 - Glycos_transf_1,Sucrose_synth k59_414742_1 479434.Sthe_0827 1.26e-31 128.0 COG0613@1|root,COG2865@1|root,COG0613@2|Bacteria,COG2865@2|Bacteria,2G5UU@200795|Chloroflexi 200795|Chloroflexi K SMART phosphoesterase PHP domain protein - - - - - - - - - - - - AlbA_2,PHP k59_840145_2 1121342.AUCO01000016_gene2779 4.34e-94 289.0 COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,24YI0@186801|Clostridia,36ED9@31979|Clostridiaceae 186801|Clostridia E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_121447_1 1227488.C477_03624 6.3e-45 160.0 COG2223@1|root,arCOG00148@2157|Archaea,2XVRN@28890|Euryarchaeota,23TD3@183963|Halobacteria 183963|Halobacteria G nitrate nitrite transporter - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_88509_1 1168289.AJKI01000012_gene274 1.11e-103 311.0 COG0076@1|root,COG0076@2|Bacteria,4NGRW@976|Bacteroidetes 976|Bacteroidetes E PFAM Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC k59_840152_1 1499967.BAYZ01000095_gene4090 4.63e-09 62.0 COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_282867_1 338966.Ppro_2769 2.08e-59 197.0 COG0702@1|root,COG0702@2|Bacteria,1QZ67@1224|Proteobacteria,42TVU@68525|delta/epsilon subdivisions,2X7SH@28221|Deltaproteobacteria 28221|Deltaproteobacteria GM NmrA-like family - - - - - - - - - - - - NAD_binding_10 k59_154986_1 1168034.FH5T_21790 2.79e-106 321.0 COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,2FQQ7@200643|Bacteroidia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family pruA - 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh k59_938646_3 1168289.AJKI01000063_gene3521 9.38e-22 99.0 COG2972@1|root,COG3292@1|root,COG2972@2|Bacteria,COG3292@2|Bacteria,4NFZB@976|Bacteroidetes 976|Bacteroidetes T PFAM Signal transduction histidine kinase, internal region - - - - - - - - - - - - His_kinase,Reg_prop k59_644718_1 1122185.N792_10720 9.55e-68 226.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1X42Y@135614|Xanthomonadales 135614|Xanthomonadales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HHH_5,Helicase_C,RecG_wedge k59_121461_1 1240350.AMZE01000023_gene1373 1.36e-50 166.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1YW6H@136845|Pseudomonas putida group 1236|Gammaproteobacteria M Nucleotidyl transferase - GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.99 ko:K00966,ko:K00992 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_121461_2 323261.Noc_2432 2.09e-66 213.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1X2FT@135613|Chromatiales 135613|Chromatiales S PFAM Aminoglycoside phosphotransferase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_546659_1 1168034.FH5T_11010 6.23e-15 72.4 COG0847@1|root,COG0847@2|Bacteria,4NJRG@976|Bacteroidetes 976|Bacteroidetes L 3' exoribonuclease, RNase T-like - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_546659_2 742767.HMPREF9456_01929 4.68e-23 97.8 COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,2FNVV@200643|Bacteroidia,22VWR@171551|Porphyromonadaceae 976|Bacteroidetes E Catalyzes the hydrolysis of Xaa-His dipeptides - - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_282877_1 335543.Sfum_0121 3.91e-97 298.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MRAR@213462|Syntrophobacterales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_220010_1 1380390.JIAT01000011_gene2343 1.19e-28 120.0 COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria,4CRNQ@84995|Rubrobacteria 84995|Rubrobacteria S Mycobacterial 4 TMS phage holin, superfamily IV - - - - - - - - - - - - Phage_holin_4_2,Phosphodiest k59_1004209_1 929558.SMGD1_1084 5.6e-96 294.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2YMCW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iIT341.HP0476 tRNA-synt_1c k59_1004209_2 765869.BDW_06790 7.52e-62 211.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2MSS0@213481|Bdellovibrionales,2WIVY@28221|Deltaproteobacteria 213481|Bdellovibrionales C malic protein domain protein maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic k59_774750_1 1195236.CTER_0272 1.26e-109 336.0 COG4733@1|root,COG4733@2|Bacteria,1UZXB@1239|Firmicutes,24AGG@186801|Clostridia,3WHNI@541000|Ruminococcaceae 186801|Clostridia G hydrolase family 9 - - - - - - - - - - - - CBM_3,Dockerin_1,Glyco_hydro_9 k59_938669_1 2850.Phatr40470 1.95e-07 58.2 2D01K@1|root,2SCEZ@2759|Eukaryota 2850.Phatr40470|- - - - - - - - - - - - - - - - k59_18005_1 713586.KB900536_gene2210 3.43e-145 434.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales 135613|Chromatiales L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_971026_1 1454004.AW11_03118 4.05e-81 252.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria,1KQTZ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Required for the activity of the bacterial periplasmic transport system of putrescine potF - - ko:K02055,ko:K11069,ko:K11073 ko02010,ko02024,map02010,map02024 M00193,M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11,3.A.1.11.1,3.A.1.11.2 - - SBP_bac_8 k59_447136_1 1454004.AW11_01100 1.32e-66 226.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_677899_1 1249627.D779_3815 8.14e-89 279.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_774758_1 1168034.FH5T_02745 4.42e-123 365.0 COG0488@1|root,COG0488@2|Bacteria,4NEHU@976|Bacteroidetes,2FMW7@200643|Bacteroidia 976|Bacteroidetes S ABC transporter, ATP-binding protein - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_187559_1 506534.Rhein_2797 1.49e-47 164.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1WWM3@135613|Chromatiales 135613|Chromatiales S PFAM Alpha beta hydrolase - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4 k59_709603_1 1216007.AOPM01000053_gene2305 3.01e-10 67.4 COG1404@1|root,COG3291@1|root,COG4935@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4935@2|Bacteria,1MU3S@1224|Proteobacteria,1RSP9@1236|Gammaproteobacteria,2Q10K@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - PKD,P_proprotein,Peptidase_S8 k59_971031_1 1121405.dsmv_3127 7.75e-62 201.0 COG1149@1|root,COG1149@2|Bacteria,1QYGR@1224|Proteobacteria,43CD0@68525|delta/epsilon subdivisions,2X7NV@28221|Deltaproteobacteria,2MPP3@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM 4Fe-4S - - - - - - - - - - - - Fer4 k59_578868_1 1121104.AQXH01000001_gene1132 2.87e-23 98.2 COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,1IRMR@117747|Sphingobacteriia 976|Bacteroidetes J Amidase gatA - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_447147_1 413404.Rmag_0129 3.46e-101 306.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,1RQ1A@1236|Gammaproteobacteria,1J9FG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MBOAT, membrane-bound O-acyltransferase family algI - - - - - - - - - - - MBOAT k59_282892_2 416348.Hlac_3159 0.000355 42.7 COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,23SF2@183963|Halobacteria 183963|Halobacteria E ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_382595_1 1392490.JHZX01000001_gene2298 2.46e-77 245.0 COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,1HYB7@117743|Flavobacteriia 976|Bacteroidetes G alpha amylase, catalytic - - - - - - - - - - - - Alpha-amylase,Alpha-amylase_C,Malt_amylase_C k59_382595_2 1089550.ATTH01000001_gene1363 1.25e-208 595.0 COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,1FJZQ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_220036_1 998088.B565_0561 4.52e-52 174.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1Y3F2@135624|Aeromonadales 135624|Aeromonadales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_546668_1 1216932.CM240_2242 5.74e-26 108.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,36DFC@31979|Clostridiaceae 186801|Clostridia S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_480203_1 1121396.KB893077_gene745 1.27e-91 287.0 COG1075@1|root,COG1075@2|Bacteria,1R5PF@1224|Proteobacteria,43BHB@68525|delta/epsilon subdivisions,2X6VQ@28221|Deltaproteobacteria,2MMMX@213118|Desulfobacterales 28221|Deltaproteobacteria S Alpha/beta hydrolase of unknown function (DUF915) - - - - - - - - - - - - DUF915 k59_220056_1 1121396.KB893071_gene1258 2.16e-80 249.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2WJ8B@28221|Deltaproteobacteria,2MHUA@213118|Desulfobacterales 28221|Deltaproteobacteria O hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_480766_2 713586.KB900536_gene534 6.12e-21 94.4 COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria,1SWBY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_283484_1 709032.Sulku_1732 1.05e-113 336.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2YMQ6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_351816_3 1449345.JHWC01000003_gene366 1.46e-16 80.9 COG3658@1|root,COG3658@2|Bacteria,1REFV@1224|Proteobacteria,42Q0G@68525|delta/epsilon subdivisions,2YN98@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome - - - - - - - - - - - - DHC,Ni_hydr_CYTB k59_252381_1 760192.Halhy_5393 8.59e-51 180.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,4NF9S@976|Bacteroidetes,1IPJD@117747|Sphingobacteriia 976|Bacteroidetes L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt k59_388547_1 556268.OFAG_01273 4.32e-05 45.4 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,472UW@75682|Oxalobacteraceae 28216|Betaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_877104_1 1121405.dsmv_0890 5.01e-168 483.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MIDP@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase for insertion sequences IS1326 IS1353 (IS21 IS408 IS1162 family protein) - - - - - - - - - - - - rve k59_256565_1 1049564.TevJSym_ac01660 1.72e-63 199.0 COG1309@1|root,COG1309@2|Bacteria,1PH8D@1224|Proteobacteria,1RW67@1236|Gammaproteobacteria,1J77A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_552289_1 765910.MARPU_00140 1.47e-98 309.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_388550_1 1127673.GLIP_2700 9.81e-54 190.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_58983_1 50452.A0A087GEQ7 6.64e-53 184.0 COG1053@1|root,KOG2403@2759|Eukaryota,37JZR@33090|Viridiplantae,3G82J@35493|Streptophyta,3HPER@3699|Brassicales 35493|Streptophyta C Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) SDH1-1 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005749,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006119,GO:0006121,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016627,GO:0016999,GO:0017076,GO:0017144,GO:0019637,GO:0019693,GO:0019752,GO:0019866,GO:0022900,GO:0022904,GO:0030312,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0035639,GO:0036094,GO:0042773,GO:0042775,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045257,GO:0045273,GO:0045281,GO:0045283,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046914,GO:0050897,GO:0055086,GO:0055114,GO:0070469,GO:0071704,GO:0071944,GO:0072350,GO:0072521,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902494,GO:1990204 1.3.5.1 ko:K00234 ko00020,ko00190,ko01100,ko01110,ko01120,ko01130,ko01200,ko04714,ko04932,ko05010,ko05012,ko05016,map00020,map00190,map01100,map01110,map01120,map01130,map01200,map04714,map04932,map05010,map05012,map05016 M00009,M00011,M00148 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_58983_2 582402.Hbal_0305 2.76e-11 63.5 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,43X0U@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_10,Fer4_17,Fer4_8 k59_224889_1 985665.HPL003_02025 1.89e-39 147.0 COG0364@1|root,COG0364@2|Bacteria,1TPYF@1239|Firmicutes,4HA73@91061|Bacilli,26SGS@186822|Paenibacillaceae 91061|Bacilli G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_649507_1 1049564.TevJSym_at00030 2.56e-09 59.7 28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_649507_2 472759.Nhal_0092 5.33e-27 109.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_484351_2 1121413.JMKT01000008_gene1569 3.08e-26 106.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2WJ4C@28221|Deltaproteobacteria,2M83X@213115|Desulfovibrionales 28221|Deltaproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 1.21.98.1,2.5.1.120,2.5.1.77 ko:K11779,ko:K11784,ko:K18285 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396,R10667 RC00021,RC01381,RC02329,RC03002,RC03007,RC03234 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3391 Radical_SAM k59_160577_2 1168034.FH5T_10480 2.37e-36 130.0 COG3279@1|root,COG3279@2|Bacteria,4NNHE@976|Bacteroidetes,2FUZW@200643|Bacteroidia 976|Bacteroidetes T LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_844432_1 118161.KB235919_gene6210 5.35e-22 94.0 2CHT5@1|root,32CXB@2|Bacteria,1G74Q@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - Calci_bind_CcbP k59_649511_1 595460.RRSWK_06187 9.23e-64 209.0 COG0348@1|root,COG0348@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding - - - ko:K02574 - - - - ko00000 - - - Fer4,Fer4_5 k59_320536_2 913325.N799_10780 4.41e-18 86.3 COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales 135614|Xanthomonadales S Putative adhesin - - - - - - - - - - - - DUF4097 k59_1040999_1 326298.Suden_0669 3.55e-70 222.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,42NKR@68525|delta/epsilon subdivisions,2YMU1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_1040999_2 1537917.JU82_07970 9.19e-48 165.0 COG5000@1|root,COG5000@2|Bacteria,1R0XZ@1224|Proteobacteria,43D3A@68525|delta/epsilon subdivisions,2YTG0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T phosphorelay sensor kinase activity - - - - - - - - - - - - dCache_3 k59_453191_1 1336233.JAEH01000028_gene407 8.19e-41 145.0 COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,1RN6A@1236|Gammaproteobacteria,2Q9CK@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM NAD-dependent epimerase dehydratase yfcH - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_484369_1 395019.Bmul_0795 2.6e-05 45.4 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,1K3FF@119060|Burkholderiaceae 28216|Betaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_484369_2 207954.MED92_18263 5.21e-48 160.0 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,1XK4C@135619|Oceanospirillales 135619|Oceanospirillales MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_59002_1 1168034.FH5T_04945 1.74e-48 159.0 COG1136@1|root,COG1136@2|Bacteria,4NGDU@976|Bacteroidetes,2FKZC@200643|Bacteroidia 976|Bacteroidetes V Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_59002_2 1168034.FH5T_04940 1.54e-54 178.0 COG0177@1|root,COG0177@2|Bacteria,4NE7K@976|Bacteroidetes,2FMKR@200643|Bacteroidia 976|Bacteroidetes L TIGR02757 family - - - - - - - - - - - - DUF2400 k59_355907_1 2340.JV46_23780 1.74e-18 79.7 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1J6PI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_355907_2 748247.AZKH_1347 8.32e-57 190.0 COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,2KZTK@206389|Rhodocyclales 206389|Rhodocyclales K WYL domain - - - - - - - - - - - - WYL k59_484377_2 1192034.CAP_6914 1.85e-14 70.5 2EH48@1|root,33AW7@2|Bacteria,1NIYU@1224|Proteobacteria,42XKK@68525|delta/epsilon subdivisions,2WSKU@28221|Deltaproteobacteria,2Z1HY@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_484377_3 765910.MARPU_10495 7.02e-09 58.2 2DQWF@1|root,3392H@2|Bacteria,1N93V@1224|Proteobacteria,1SFNS@1236|Gammaproteobacteria,1WZ6Y@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF2934) - - - - - - - - - - - - DUF2934 k59_682618_1 1168289.AJKI01000016_gene1948 1.74e-77 248.0 COG2211@1|root,COG2211@2|Bacteria,4NE3B@976|Bacteroidetes,2FPMF@200643|Bacteroidia,3XIS3@558415|Marinilabiliaceae 976|Bacteroidetes G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_388609_2 1249480.B649_06585 8.7e-97 289.0 COG0454@1|root,COG0456@2|Bacteria,1Q9FS@1224|Proteobacteria,42YQT@68525|delta/epsilon subdivisions,2YRH5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_10 k59_808655_1 1156919.QWC_22444 1.62e-52 176.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,3T2TD@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_520257_1 700598.Niako_3078 1.44e-47 170.0 COG4198@1|root,COG4198@2|Bacteria,4NEQC@976|Bacteroidetes,1IVKP@117747|Sphingobacteriia 976|Bacteroidetes S Starch-binding associating with outer membrane - - - - - - - - - - - - SusD-like_2 k59_745511_1 479434.Sthe_2697 5.73e-93 280.0 COG1656@1|root,COG1977@1|root,COG1656@2|Bacteria,COG1977@2|Bacteria,2G6GZ@200795|Chloroflexi,27Y8I@189775|Thermomicrobia 189775|Thermomicrobia H Mut7-C ubiquitin - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_943789_1 1231057.AMGD01000001_gene2417 1.03e-42 155.0 COG0702@1|root,COG0702@2|Bacteria,1TT3N@1239|Firmicutes,4HB09@91061|Bacilli 91061|Bacilli GM NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_59635_1 1288494.EBAPG3_5740 1.41e-67 227.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,2VJDF@28216|Betaproteobacteria 28216|Betaproteobacteria M rhs element vgr protein - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD k59_944397_1 749222.Nitsa_1874 4.42e-104 316.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YMGI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_552959_1 1282361.ABAC402_10395 2.72e-38 139.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria,2KFY8@204458|Caulobacterales 204458|Caulobacterales E Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_552959_2 1121456.ATVA01000011_gene1386 1.43e-32 121.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria,2MGBC@213115|Desulfovibrionales 28221|Deltaproteobacteria C Zinc-binding dehydrogenase tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_877753_1 1085623.GNIT_1254 5.08e-11 65.5 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,467TG@72275|Alteromonadaceae 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_225581_1 1535422.ND16A_0818 2.27e-13 68.2 2C3PP@1|root,2Z954@2|Bacteria,1MXGR@1224|Proteobacteria,1S3GQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Branched-chain amino acid aminotransferase - - - - - - - - - - - - - k59_225581_2 392499.Swit_4519 5.82e-63 205.0 COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U69N@28211|Alphaproteobacteria,2KDKH@204457|Sphingomonadales 204457|Sphingomonadales S Methyltransferase - - - - - - - - - - - - Methyltransf_25,PCMT k59_976204_1 395494.Galf_2592 2.8e-21 94.4 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2VJX1@28216|Betaproteobacteria,44VIP@713636|Nitrosomonadales 28216|Betaproteobacteria H UbiA prenyltransferase family menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_617982_1 572544.Ilyop_1496 3.47e-152 454.0 COG2217@1|root,COG2217@2|Bacteria,3796E@32066|Fusobacteria 32066|Fusobacteria P Psort location CytoplasmicMembrane, score - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_1041665_2 929558.SMGD1_0386 1.32e-90 284.0 COG0840@1|root,COG0840@2|Bacteria,1N5N4@1224|Proteobacteria,42RSG@68525|delta/epsilon subdivisions,2YRU6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_845120_1 1242969.ATCC51562_1409 6.35e-52 177.0 COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2YM94@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S permease - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k59_126773_1 460265.Mnod_7250 2.66e-67 218.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_976225_1 1249480.B649_04760 2.13e-33 119.0 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_809272_1 522306.CAP2UW1_1243 5.81e-68 233.0 COG0022@1|root,COG0332@1|root,COG0508@1|root,COG1071@1|root,COG0022@2|Bacteria,COG0332@2|Bacteria,COG0508@2|Bacteria,COG1071@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,1KPNJ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH_1 - 1.2.4.4,2.3.1.180 ko:K00648,ko:K11381 ko00061,ko00280,ko00640,ko01100,ko01110,ko01130,ko01212,map00061,map00280,map00640,map01100,map01110,map01130,map01212 M00036,M00082,M00083 R07599,R07600,R07601,R07602,R07603,R07604,R10707,R10996,R10997 RC00004,RC00027,RC00627,RC02729,RC02743,RC02883,RC02888,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_584961_1 63737.Npun_R1526 3.67e-48 175.0 COG0243@1|root,COG0243@2|Bacteria,1G0DW@1117|Cyanobacteria,1HJZP@1161|Nostocales 1117|Cyanobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narB GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.7.7.2 ko:K00367 ko00910,ko01120,map00910,map01120 M00531 R00791 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_877780_1 1266914.ATUK01000012_gene213 1.31e-49 177.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2 k59_257284_1 1168034.FH5T_17065 1.45e-75 237.0 2C2F5@1|root,32WND@2|Bacteria,4NNJR@976|Bacteroidetes,2FTPA@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_746173_1 323261.Noc_2999 7.29e-75 236.0 COG2807@1|root,COG2807@2|Bacteria,1QW3Y@1224|Proteobacteria,1T2RW@1236|Gammaproteobacteria,1X2P1@135613|Chromatiales 135613|Chromatiales P PFAM Major Facilitator Superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_584971_1 1219375.CM002139_gene3159 1.31e-79 263.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1X3YE@135614|Xanthomonadales 135614|Xanthomonadales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_161276_1 929558.SMGD1_2083 5.34e-140 421.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2YR60@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Domain of unknown function (DUF3458_C) ARM repeats - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_584978_2 1319815.HMPREF0202_01624 3.13e-215 605.0 COG0008@1|root,COG0008@2|Bacteria,379AM@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_161284_1 797210.Halxa_3451 2.41e-48 171.0 COG2317@1|root,arCOG04247@2157|Archaea,2XT2Q@28890|Euryarchaeota,23SKK@183963|Halobacteria 183963|Halobacteria E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues cxp - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 k59_520824_1 1249480.B649_00210 4.79e-79 260.0 COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,42PR3@68525|delta/epsilon subdivisions,2YN2Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Mitochondrial degradasome RNA helicase subunit C terminal - - 3.6.4.13 ko:K17675 - - - - ko00000,ko01000,ko03029 - - - Helicase_C,SUV3_C k59_454110_1 870187.Thini_4182 4.98e-90 275.0 COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,1RSA6@1236|Gammaproteobacteria,45ZTC@72273|Thiotrichales 72273|Thiotrichales S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_553005_1 56780.SYN_01146 6.89e-13 68.9 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42M0R@68525|delta/epsilon subdivisions,2WJE6@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_553005_2 1894.JOER01000005_gene2639 3.15e-12 69.3 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_288679_1 1168034.FH5T_01000 6.86e-128 388.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE4N@976|Bacteroidetes,2FQUA@200643|Bacteroidia 976|Bacteroidetes C Dehydrogenase E1 component - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_618027_1 1168034.FH5T_21145 3.94e-84 251.0 COG0314@1|root,COG0314@2|Bacteria,4NP1X@976|Bacteroidetes 976|Bacteroidetes H Molybdopterin converting factor moaE - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_746203_1 1042375.AFPL01000052_gene381 4.96e-37 136.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,464AY@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains cbrB - - - - - - - - - - - Response_reg,Sigma54_activat k59_746203_2 384676.PSEEN4729 2.41e-25 107.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_584999_1 1123368.AUIS01000019_gene1223 1.86e-61 191.0 2AHT8@1|root,3185S@2|Bacteria,1RH98@1224|Proteobacteria,1S7UG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_584999_2 1123368.AUIS01000019_gene1224 5.07e-54 184.0 COG0569@1|root,COG1226@1|root,COG0569@2|Bacteria,COG1226@2|Bacteria,1R3QQ@1224|Proteobacteria,1RPFS@1236|Gammaproteobacteria,2NC05@225057|Acidithiobacillales 225057|Acidithiobacillales P Ion channel - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_N k59_976277_1 1168034.FH5T_10340 1.57e-118 345.0 COG3177@1|root,COG3177@2|Bacteria,4NHPW@976|Bacteroidetes,2FQXS@200643|Bacteroidia 976|Bacteroidetes K Fic/DOC family - - - - - - - - - - - - Fic,HTH_24 k59_193458_1 755731.Clo1100_2117 1.33e-143 427.0 COG0477@1|root,COG0477@2|Bacteria,1UNMW@1239|Firmicutes,25ECT@186801|Clostridia,36UWC@31979|Clostridiaceae 186801|Clostridia EGP TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_193458_2 203119.Cthe_2115 7.08e-37 127.0 COG0011@1|root,COG0011@2|Bacteria,1VBWM@1239|Firmicutes,25DPD@186801|Clostridia,3WJSB@541000|Ruminococcaceae 186801|Clostridia S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP k59_193458_3 1121428.DESHY_30067___1 7.32e-67 215.0 COG0600@1|root,COG0600@2|Bacteria,1TRFD@1239|Firmicutes,25C7Z@186801|Clostridia,261JQ@186807|Peptococcaceae 186801|Clostridia U ABC-type nitrate sulfonate bicarbonate transport system permease component - - - - - - - - - - - - BPD_transp_1 k59_193458_4 1121324.CLIT_10c02830 6.16e-157 449.0 COG0715@1|root,COG0715@2|Bacteria,1TPAD@1239|Firmicutes,24A2V@186801|Clostridia,25R75@186804|Peptostreptococcaceae 186801|Clostridia P NMT1/THI5 like - - - - - - - - - - - - NMT1 k59_193458_5 1121324.CLIT_10c02820 8.96e-92 277.0 COG1116@1|root,COG1116@2|Bacteria,1TSW5@1239|Firmicutes,25AZG@186801|Clostridia,25SAI@186804|Peptostreptococcaceae 186801|Clostridia P ABC transporter, ATP-binding protein - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_193458_6 526218.Sterm_2067 1.14e-10 60.8 COG0084@1|root,COG0084@2|Bacteria 2|Bacteria L hydrolase, TatD family' M1-591 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_520837_1 1049564.TevJSym_aj00200 5.44e-16 76.6 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1J4SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_520837_2 1121456.ATVA01000015_gene2426 2.13e-05 48.1 2E83A@1|root,332H7@2|Bacteria,1NK62@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - VPEP k59_877838_1 1123274.KB899418_gene2365 1.99e-60 208.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,2J5C6@203691|Spirochaetes 203691|Spirochaetes E Amino acid kinase family - - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_976283_1 425104.Ssed_1728 5.03e-46 159.0 COG4313@1|root,COG4313@2|Bacteria,1R6GU@1224|Proteobacteria,1S3GE@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Protein involved in MetA-pathway of phenol - - - - - - - - - - - - Phenol_MetA_deg k59_1041741_1 1304885.AUEY01000040_gene1620 1.77e-37 140.0 COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,42SGU@68525|delta/epsilon subdivisions,2WPBP@28221|Deltaproteobacteria,2MKJU@213118|Desulfobacterales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_715063_1 911239.CF149_02114 9.35e-50 174.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 ## 26427 queries scanned ## Total time (seconds): 179.26846742630005 ## Rate: 147.42 q/s